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<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS00</accession>
    <name>A0A914XS00_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XS00"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10056.t1">
        <property type="protein sequence ID" value="PSU_v2.g10056.t1"/>
        <property type="gene ID" value="PSU_v2.g10056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF2">
        <property type="entry name" value="CONSERVED PLASMA MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="TPM" evidence="3">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10056.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32810" checksum="A83E574CBBA262D5" modified="2023-02-22" version="1">MLSNNIEFGDKLADEYGLSEQICKNYLLLIGVEAAKMAYTRTGSSLKLPEDLMFRIYNQSENVFKEKNYMEGLNKMIDEIGDQMIDPFKYETTTSVVIETEATTAETTTEDPSFNISSSVDLIWTEISTTQASVKQTVNNPWWMFVCLGIAILSTIIVLIMVLISKRHTFKTLQMQTVIPVPITTTKSNCPSDDNNSDRFATITIPRRRVDLETEIKNEEEKQQKHEIKDEEAEADQRSQVTVASDEEHSYRITEAITSDNNNISSSSQSEIHVESPLTSPKSQNATRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSY4</accession>
    <name>A0A914XSY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenomatous polyposis coli (APC) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XSY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10382.t1">
        <property type="protein sequence ID" value="PSU_v2.g10382.t1"/>
        <property type="gene ID" value="PSU_v2.g10382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045295">
        <property type="term" value="F:gamma-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026818">
        <property type="entry name" value="Apc_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607">
        <property type="entry name" value="ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607:SF12">
        <property type="entry name" value="APC-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="894"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10382.t1"/>
        </source>
    </evidence>
    <sequence length="955" mass="106483" checksum="A2443B43E5A3934D" modified="2023-02-22" version="1">MSCGHPEDPGFLLPGETLEDFVSRYMSQFQYEETRHLETTSSDLSNLENAFLQIKDIIKRVTNGLRLDSFMHILSLTSKIHHSIYCLRQYKRNPSLKNETFNDYVIQVKIALDELLRDSYEDEKRKLEVIFGLVEVVAELLIADIEIFELNPDPSKYEEAKTIRKLIANLLTNLVFGNAQSKRKLCNYSGFIPEVTRIIEKSPGLSVFYAALIRNLSWQADNSMKISLARIVPALSMAAIKAHSNGDSKCLLASLSALWNLGSHSMENKKAMCETTNFLSLIISLLDCAPSHTTMVENASGILKYACGYIITKPNLLQQLHNAKLIRQLLNLLNSSSFTIVINALNSLCQLAQHDPYTQMKLTKTQPRTLLDKLRNSVHDEVRNTVKELLNHLNQSSVAGYYSMPRNPQQTMNMYYSTTSESAYSSGGSTLLPTRGGYSHYPISVHPVNPFLPYSSPQHHHHHQQQQQQQNTLPKSMRIFKPEQHRDTVASHCQELSSQFLRDIKLEAGMDIPESLLATRSGSVQSLTDEIGTDSSWRSSDNTDAPNSADLSPVSESEIPDSPTEFAMKQVEISAQKYGRNCGHKEANNRGSFNNDDEDEEEDLYGIQMNHRNKTLSRDELSQAIVNALPPPKHSATTPHSLQSTPRLPKPSNIMPQQLFTEQDEISDIDFDDESFNDEPVPPPSSIPSSSSTTTSNASAATPTTISMSKNEQSSTAATTTKFMKDYFIVGTQTVPQQPPQQFHHHPLQVMMMNNPTPPSRDTFMDAMEISSLLQSPNTLEKLRDASQLYPFNRDHYPNHNDNDRGELSDDSYCCSSEDIVALEDLTAVPEDVDQAFQAEKVIIDCGSLSRGLRPSSKLPRSFPTTTVTPSADKSTNVKIGLLSAATIKRLSKSRNPLPMIQSNKTSSSKSKSARVSPFNYKEPTLPLPPPPSSAAATEKTQNSSKSHKLLVTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVC8</accession>
    <name>A0A914XVC8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10928.t1">
        <property type="protein sequence ID" value="PSU_v2.g10928.t1"/>
        <property type="gene ID" value="PSU_v2.g10928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000093">
        <property type="entry name" value="Zinc metalloproteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000028">
        <property type="entry name" value="Zinc metalloproteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF813">
        <property type="entry name" value="ZINC METALLOPROTEINASE DPY-31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 15 16" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="18">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="17">
        <location>
            <begin position="235"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10928.t1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47028" checksum="5E9482B6DB5FD94E" modified="2023-02-22" version="1">MSNIIIHAKQKNILALREQRVIELALEHWHNITCLNFERRDDEPKGNRIVFTDVDGCASNVGKHPLGEPQFVSLAPECIRLGVIAHEVAHALGFWHEQSRPDRDYYVKVRWENIDRDSKGQFLKEQPADVDNGGVPYDLGSIMHYRSKAFARYDDLFTMNTYISDYQRTIGQRDQLSFNDIRLMNNIYCQNTCSRKLPCQRGGYTDPRRCDRCRCPDGFTGQYCEQVMPGYGADCGGRVQVGHTWTRITSPGYPAEFREGQECSWLLVAPPGQHVQLQFYSEFEMYCKVRHSLCMDYVEIRNSTDFANTGMRYCCFGTPHSSIVSATEDMLVLFRSFYRGGKGFQAQVRAIPHTGSWSSWTAFSECSASCGACGTQHRTRECRPPNAYLQGVSEKVLTFFHASSNKKLTFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVN4</accession>
    <name>A0A914XVN4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Complex I-39kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 39 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1. Interacts with SLC2A4. Interacts with CLOCK. Interacts with RAB5IF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA9 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVN4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1059.t1">
        <property type="protein sequence ID" value="PSU_v2.g1059.t1"/>
        <property type="gene ID" value="PSU_v2.g1059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1059.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16818" checksum="1B3EB3836D55BA0E" modified="2023-02-22" version="1">MSRFSPFMPLIGGGKTQFQPVYVGDVAEVVARAVEGKLQAGKAYELGGAEVLTLRRCMELSLEVINRKRIFINLPWWVASLQGKILGLLPNPPLTSDHVKLLKSNNVVSQEAADADLTLEGLGIKPQAVDAILPSYLWRFRVLGQYDKASLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW71</accession>
    <name>A0A914XW71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW71"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10031.t1">
        <property type="protein sequence ID" value="PSU_v2.g10031.t1"/>
        <property type="gene ID" value="PSU_v2.g10031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10031.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19808" checksum="78E6BF7364B14DA6" modified="2023-02-22" version="1">MYASLYEATVREFGQVIVITKYRTLIDVYAAATPLLILFYYSIITVTFILISLRMSALKKLLTSTTASMQTQINIILLVQAGVPLIMNVLPPIALCLSWFLEFNTPNEFFIFGVVNAWTPCINGLTTLLVIKPYRRYYCHLLLKLYYRREEDIPLFKTFRSRSIVDSVKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX35</accession>
    <name>A0A914XX35_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XX35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11773.t1">
        <property type="protein sequence ID" value="PSU_v2.g11773.t1"/>
        <property type="gene ID" value="PSU_v2.g11773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF143">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11773.t1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51612" checksum="F6628BAC62198CA8" modified="2023-02-22" version="1">MVGFRDRFLESLRDYGELFDPTINTFYARYSLISSQTDFCADILERIDEIEYLKYENFDLVISNQIDYCDVALAHYFGPKAFAWVITGPLHENNNYVLGVPAMPSYLPTLEDNEMGGEMTFLERMQNFWNWILATALHRYTAWRVNRLFRKYVSPDFPDVDTLSAKSSLVFVNNDEFLDFARPILHKTIYIGGAGLQKPKPLSPYFENIMNKGTRGVVLVSFGTAVYTPSFSIQNRKKIFKAFAAFPEYHFLMKISPGDNGTIELAKNIPNIEFVEWLPQSDLLNHPNIKAFVSHGGFNSVLETSRRGVPVIILPFFFDQFRNGKMVEHREIGKVISKTNFGEESLKISLKELLYNPKYKENAERLKRLMTTKPNQPDETFLKWTNFLLENEDFPELIPVGAKMNLISYLSLDVVAVLCVSLIVSLWTFKIFLQRVFSSFNLKLKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYL9</accession>
    <name>A0A914XYL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large ribosomal subunit protein bL35m</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYL9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12306.t1">
        <property type="protein sequence ID" value="PSU_v2.g12306.t1"/>
        <property type="gene ID" value="PSU_v2.g12306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019338">
        <property type="entry name" value="Ribosomal_bL35m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12306.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="19006" checksum="A440E83C7901895B" modified="2023-02-22" version="1">MFVSVTAKPLTSKVLSTILLPTRGIANIPHWEHHIRFDPAHGRKRPSQDVLDRFKRLNNGMWIRPHPGRNKLRYVKSEVFHETADYFETCKKEECMMLDKLMTPFWLRRKHYPNDPYEPYHTRHGLTSPRVDYKGRFVRERSKVLMDDTTAMKHFSDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYY2</accession>
    <name>A0A914XYY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYY2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10895.t1">
        <property type="protein sequence ID" value="PSU_v2.g10895.t1"/>
        <property type="gene ID" value="PSU_v2.g10895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10895.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17979" checksum="E0674C4BDF3F079F" modified="2023-02-22" version="1">MHPGNIIWGIDNDGDVKQELEAIIDWQTMHEGSPMEDLARFLAYCADGVVRRQSEAIAFDYYIECLTKEFEGDSSKVPYTSEQLKKSYNLYFVSQAFFTIFDFQFFFSALEGKISSPTIKDAYHDYGVLKSLHCIEDADKILQSTEFRHFYDKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZT8</accession>
    <name>A0A914XZT8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XZT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12041.t1">
        <property type="protein sequence ID" value="PSU_v2.g12041.t1"/>
        <property type="gene ID" value="PSU_v2.g12041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12041.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22348" checksum="54DEAF879DA735C4" modified="2023-02-22" version="1">MGIADKLASRTFKESELPKLFFAESRCFRPEISKSASEAKLYRVHEFNKLEMFAICTPTQSSKVLQMFLEIQIKIWSKLGVKYRVLDMPSEELGAAASRKYDIEAWMPGRGIYGEVSSTSNCTDYQARRLGIKYQNEGNSGEECFVHTCNGTAMASTRALITVLETFQTSRGFVPPEILKQFLPKDRHRDKLKMAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZY5</accession>
    <name>A0A914XZY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZY5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1209.t1">
        <property type="protein sequence ID" value="PSU_v2.g1209.t1"/>
        <property type="gene ID" value="PSU_v2.g1209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1209.t1"/>
        </source>
    </evidence>
    <sequence length="854" mass="97423" checksum="A8C42A0917E8096A" modified="2023-02-22" version="1">MSSTESRESSTRLSSYPRIPRNDLEVQDQLGCGSFGSVYRGIWRCDGKEQVVALKKVFMLEKEVDILSQIRHRNIIHFFGVSQANPDFYIVTEYAEHGSLYEYLHNDSAELPFDLILQWALQIAHGVHYLHFEAPATIIHRDLKSKNVVLSKGYGNTIICKLCDFGTSKDLTHSFTRPTWAGTAAWMSPEIITQKDGITPATDVWSYAVVLWELVSREVPYKGLTEFKIYSIISQHGERLVIPETCPQKLANLLKNCWYTEPRDRIDMKIIILELQKMEANAELHLECTNFVKQKGTWRGEIDKQLKALNELKIDLARQKEELEKREQALTRRETTHQSFLHLQEFFTFNDVSSLSEDEICQWLRLLADTAPEEPDPEVIEGLITYIQKFRIDGSRILNVSEKDLQQLGIQKGTFCDYLLSHIEELQSRYAFETMPLRMSSIPEKRNKNDKSKQPFDFPLVLHIGLYQREMCSTTCSTRFRFKVFVDSDWQQCTMTEDMPSEIYDSATVIKDVCISLVDSNKRVLLETVRCLCPPFGYLEWINAPQDGSPVSVTITVTYTDQVMRPRNTCINAEITDFSCAQTVHNRVVMLKLRPIPTNTSISRVNSALFNNSIQSPTPTNNNINSIQSVWRRRRSSFGPDGLNPIERARNIALLNIRGANAGIRSHEIQHSLSVTDDSQDDQTYFRPRSISHYIPSPGSATPSSAHAAAAMMANSAINHNPSPSPKPMLRPKAYSNPFVQFRRSRKNSELSSEANSVTNSDSKHFASFFLDSSSSPPVIHEHHAVPPPLKMTSPSPSPTLTLKFEEEENEPNEIEQCCKNDCRHRKAIIPPKEIQDIDEVEPLKIEKKKCVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0D2</accession>
    <name>A0A914Y0D2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0D2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12240.t1">
        <property type="protein sequence ID" value="PSU_v2.g12240.t1"/>
        <property type="gene ID" value="PSU_v2.g12240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12240.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="32339" checksum="01222B78BFF52307" modified="2023-02-22" version="1">MLRDLGDWKDTVGEDERNHWIDKFDKMPKHHHQQHDTNSESMKHEKSESSNYHNLLDRLSPQEREAAKIIWEEQEKALNRQHHPNGTNPNNGQRVNGTIDDIRNAINESNPGSIDTEHDQKIHQDLTNNTRWQQKHNETFDKIKDAKNDINDKINDTKHDVSQKWNDTINDVNNRIDDAKNDIENKKQEIRDNLNDTNKNINDKMNDQQMLRNDTHDIYTDAQKDVNQKLNDTKNDVINQWNNTAKDVQNRINDTKDDIENDKYKGINEISPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y163</accession>
    <name>A0A914Y163_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y163"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11575.t1">
        <property type="protein sequence ID" value="PSU_v2.g11575.t1"/>
        <property type="gene ID" value="PSU_v2.g11575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11575.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18645" checksum="45289D8BAEAB6D99" modified="2023-02-22" version="1">MTSMNGHRFLTLPTSLKPAILILIILSMIFAGSSSPSGINTFSWSWFFWFTIIVQLIFIIVVIALFALEMERLMTMGRDAWPIAEMAYSVIFGIFTVINIFVVSGWHSVAKNASLPVLAAISCFVLFVLYALGGFMMFRLWKGFVQSGATQNPTAATQPGNIQGMHPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1N6</accession>
    <name>A0A914Y1N6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1N6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14101.t1">
        <property type="protein sequence ID" value="PSU_v2.g14101.t1"/>
        <property type="gene ID" value="PSU_v2.g14101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14101.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28132" checksum="CF647C49BEE3488E" modified="2023-02-22" version="1">MHGLQIISPRDSIVLTRLNISDNKGQGMSVLTTNLKATNEQTKIPGGPMSLPYHAVGLLEMCAAGKSVEIHDRIILYYKYDSRPVDCVKVFTSKTRYLGFRFLHANFYGVLNGVGRSDALSIYSDSSFSPAALLLQYNSDSDFTKTQLPLRSQILALHLRATAADEEFGFIAEISAIPTTPDSRQVEEISLRNSRFINNDRGALNYRNVGEVGPNVIIEQCSIDKNGYFLFGNVSTSSQAIEMHLHNTLVIIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2G4</accession>
    <name>A0A914Y2G4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MaoC-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2G4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14366.t1">
        <property type="protein sequence ID" value="PSU_v2.g14366.t1"/>
        <property type="gene ID" value="PSU_v2.g14366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF56">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14366.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11613" checksum="793DD74827890D49" modified="2023-02-22" version="1">MNPLHIDPMFAQMGGFKQPILHGMCTLGFSTRHVVETFADGDARRFKAVKARFTSPVSLGSTLVTEMWKENSRIHFQTKIKETGKTVINNAYVDLIDDKNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2L6</accession>
    <name>A0A914Y2L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GP-PDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2L6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14419.t1">
        <property type="protein sequence ID" value="PSU_v2.g14419.t1"/>
        <property type="gene ID" value="PSU_v2.g14419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14419.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20348" checksum="A8EAED4144141BF8" modified="2023-02-22" version="1">MVQRCSGFADFVEFDVQLTKDKIAVIFHDFHVLVSVTKRSGSTLDLRASAEKFDETVATDFHELAVKDLKHQQLKLLHLSHHKAPENTDKLKVTCDPTEADENQPFPTLVETLRMVDMDTGFNIEIKYPMKMKDGNDECENYFERNMFIDIILNDVLTHAGCRRIVFSSFDPDICSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y300</accession>
    <name>A0A914Y300_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y300"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12154.t1">
        <property type="protein sequence ID" value="PSU_v2.g12154.t1"/>
        <property type="gene ID" value="PSU_v2.g12154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000416">
        <property type="entry name" value="Aralar1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="378"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="476"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="568"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12154.t1"/>
        </source>
    </evidence>
    <sequence length="723" mass="80901" checksum="E5CD3072AFF3650F" modified="2023-02-22" version="1">MEDGGQVLNYQLRRQKLEASNDLFHEKNSIYGIKQNSLLQRFFPFAGKARCEEKNRLQIPRANPEALRHIFDQYATVEKDGRKFMTDSDFVRKYLGLYTEENYNRETVRLLASAADTSKDGLISFEEFQAFEASLCAPDALYLTAFEIFDNNASESITADEFEKVIRHTTALQALNFDFDSEFIKRYFGRKKHRQIGYLAFCQLLHDFYEEQGLQAFEKFDKDKDGSISAESFHYIMTTVKGHLLTDYVRNNLIAVCGGASSAHKVRFPFYQAFNSMLAKIELFKRVYISLARGSFDLQVTKEEFLQATQAYAQITPYEVEIFFHLAELAHPGQRTVAMNDIERIDPDRLKRVSYMTRLTDFKAVHTKEERGIFTAFLESGYRFLLGSIAGACGATAVYPIDLVKTRMQNQRAGSYVGEVAYKNSLDCFKKVIKFEGFRGLYRGLPPQIVGVAPEKAIKLTMNDFVRDKLTIDGRISLPAEIVAGGCAGGSQVVFTNPLEIVKIRLQVAGEITQGPKINVFTVLKELGFLGLYKGAQACFLRDVPFSMIYFPVYAHAKKSTTDENGVNSPGTLFGSAFIAGVPAAALVTPADVIKTRLQVAARAGQTTYNGVIDCTRKIMKEEGPLAFWKGTGARVCRSSPQFAVTLLTYELLQRLFYVDFGGSRPTGSEASIAATLSDSSSDKTDHVGGYKLAAATFSGIEHKFGLFLPRFESKVAVAKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4G1</accession>
    <name>A0A914Y4G1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4G1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12622.t1">
        <property type="protein sequence ID" value="PSU_v2.g12622.t1"/>
        <property type="gene ID" value="PSU_v2.g12622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12622.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41291" checksum="A4A160609E9A9F4C" modified="2023-02-22" version="1">MNPNCLEMVHETIDNFYANQKEEREENENKKTEERAIPEESEDAQDFELLIETSFEPLIDDLTSDLIIREQIDDNVNDELDDELDDPDNCPVKCICGFNHLEQQTIFCEKCRIWKHIKCLKAEKYANSEAEYCCPECLGKSLPLSPSEAQDLVSKSLKLEHIDFKNKQCTELKLSGALQFEWKALLENSVDYKTSKVGRLIHEGKMRWAVIKKGQAGRVLAGFGIKAGDAVIGVNGIATYMMDAKNYCTCYRNLNLSFLPEPIIIEMKGRNGGLAHEVLPSCNPNCEIKFCLYKNNLYCYLAALCEIDNDDELTIAFPDTDHLHVNCAESSSNCSNTCPSQKSSKKSKIHASVVKEPPSKKLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5A1</accession>
    <name>A0A914Y5A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5A1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15382.t1">
        <property type="protein sequence ID" value="PSU_v2.g15382.t1"/>
        <property type="gene ID" value="PSU_v2.g15382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000003">
        <property type="entry name" value="Neuropilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="44"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="186"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="325"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15382.t1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45879" checksum="9E562E321BA958D5" modified="2023-02-22" version="1">MLNLSCGSQLPPPLHAESNRIRLNFTSDDKLVGKGFRATWKAECGGTLSLTHGVITSPHYPKYYPNADFECKYLIYPALPNDASPIVILKLLDFDMSTPSFPWRSVTAEAYGKFECIRDYLEIIDVSRNKTVAKYCQENMQSTTSAPPISIKGGIGIRFVGNQSYFEGNDMKRHRGFKISYALADCGGEIKLENDKLTGTITSPGFPLPYHNNLDCIWNITAPEDRIISAKFTNVEMELNFDRCNFDFVELYDGIQSNFSTTTTTSSSTNTTKGLMGKYCGEDTPTDYLITTTPNMTIRFHSDHSSSKGGFKLVLTATLGPKGGCGGALVATDEIQTLIPPLINGKYANGLRCLWNIKTKDPKKVIEMKFTKMNIESRRRVDDASLTGCYDFVAVSSFSWTNLHKLKTYANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5N6</accession>
    <name>A0A914Y5N6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5N6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1408.t1">
        <property type="protein sequence ID" value="PSU_v2.g1408.t1"/>
        <property type="gene ID" value="PSU_v2.g1408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1408.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8130" checksum="0B702632F0186B26" modified="2023-02-22" version="1">MFFSISGAIREVTECIADEAMLEAMEGLVIKSYHGIKTNETVKVRNKICKENKEVINSFIYCLIHADPNVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6A5</accession>
    <name>A0A914Y6A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6A5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15726.t1">
        <property type="protein sequence ID" value="PSU_v2.g15726.t1"/>
        <property type="gene ID" value="PSU_v2.g15726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15726.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23758" checksum="93FB2A15E1EAABB1" modified="2023-02-22" version="1">MCVTAYDVSGGKGFVSQVLRCTLTFVDSNSPNDVYHTILKIPSMDSMNEAKEKSEFNMDNFEKANKKDKYIFMAEVHKFECDFYNNLTTIIDVPCPKVFQTREWIIKKQEGVIHMEDLTLRGKTIMYFENINLTQVKCVIRHLAHMHYKLLTVDPKIWKGKFLKNQEAMAAISQHADIMINPMIKSSKREGKNQRSKFLICFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6D0</accession>
    <name>A0A914Y6D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6D0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15750.t1">
        <property type="protein sequence ID" value="PSU_v2.g15750.t1"/>
        <property type="gene ID" value="PSU_v2.g15750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15750.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="32543" checksum="4490FF1E31C07D79" modified="2023-02-22" version="1">MPTTSSTNDETTTQQFVVVNSQTDTIVTGQNVDVTTVESASTTNKPSTNTITEEIITQPPSTTTLETLLSSTTNNAASEVLEKVAALNEAEIKTTDMPTEVSSTNVPVKTESTVETAEKLTTISPIETTTLEKSTESVPIIVGIVGESSATLTVTTIASKINDETTASVTEEKTTVANLKATTNAETLQPITEINVETTILPVLQTTIKAAENIIGAEVKEAIENANVKAKPDVETTTNLVQSEVKDAEKEIIVKVPTTISADIPSTTISSESTITEKSVTDSPTTILQNVDETTTAGVTEKVQKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6P5</accession>
    <name>A0A914Y6P5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6P5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14428.t1">
        <property type="protein sequence ID" value="PSU_v2.g14428.t1"/>
        <property type="gene ID" value="PSU_v2.g14428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14428.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="39099" checksum="2329818D3E89D2F9" modified="2023-02-22" version="1">MSFFKSNWDDDYVERTLENICPKEKRYMPDRICGDIPFIQYRSMFATPEKYLRFLKELEKSTSRHDFLFWLFDIITAGQEKERWHISAKDLDAQVRDRVPYIQNILSYAASMDKFSEYMFQEYSKIVKNPNEMDIFNPVLRTFPNTPKIFEYRKNALENSDKSKFFDDYSVEYININPMKSLTISDLPETPPELSFEEFITEKAENQSFFAIYNHFTNLLIYNMHIPDTNTCIFVDKDPYKILQVESYMLRIKVEKLVPINIIKAQELFKKDSIVVVVVVVNDVIPEITNSTDADVDAEDSDFNMQKSIFKRAKLLCNIPSPSPNKIYFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7N5</accession>
    <name>A0A914Y7N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7N5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15287.t1">
        <property type="protein sequence ID" value="PSU_v2.g15287.t1"/>
        <property type="gene ID" value="PSU_v2.g15287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF445">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="63"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15287.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34950" checksum="E1F0A0B179832D97" modified="2023-02-22" version="1">MNKDKLYVTDGPEIPTVVQEKSLPVIIVPTKPVESFTYSTKSDEIPEIVPSFSSIDGQKYNFVETDDIYEDCGQYRKAGHDQSGVYEFKLNGNTFKALCLMESDYSWMVLQRRTSGHLLFNRSFDEYSNGFGSPSGDHWLGLEKVYQYVKKGFKLQLRIELHGDFCDECSKLGDDGYWWGDWDMAIGSKEQKYKLDISHILHGNLSDSTNDEFHRMNNGRSFTTFDEDNDEKKSINCAVFRNYGPWWHSDCTLVALNGAYASRKKVTSDMVWFHQQRKSGPNNALESYSIKPQMSLMMFRIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y843</accession>
    <name>A0A914Y843_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y843"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1492.t1">
        <property type="protein sequence ID" value="PSU_v2.g1492.t1"/>
        <property type="gene ID" value="PSU_v2.g1492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1492.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30521" checksum="D9D61C1D4849CACF" modified="2023-02-22" version="1">MQLKRNKTTKLCAAGFEVDDNGEAHYGGPLNFICTHCGSKHFENEKVSNKGLSFYGCCQHGTIKVEIPDYPEDLKKLFDLPEFNKTIRPLNNVHSFGSFNADVVNFGVNRPGPYAFVVQGQVYYQINTAITNDPNDPKSHGQLYIVDPEEAVENRIGIFNNLNSDIVKKLSTILSEINVHAKAFKMLYEEIKLQKEIAEEMGVDPLNLSLHFGIKPGQDQRRFNLQASNEVAAVFATTDDGEIPDSYITIYDKDQKKLKTENIFGIQILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y892</accession>
    <name>A0A914Y892_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y892"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13814.t1">
        <property type="protein sequence ID" value="PSU_v2.g13814.t1"/>
        <property type="gene ID" value="PSU_v2.g13814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="84"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13814.t1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47987" checksum="21AA9F43346DD289" modified="2023-02-22" version="1">MNFQDALDYSSIELKSSSNQQRQKSEQLISKRSSLLPPSTSIRRHASLAVDNPSQQLTARKGSSSKRGSVAMEQIKKIDLDEVYSVFKQLGTGRFGYVKLAEHKQSKANIAIKFFPRPQIKQSDFVREYNFSFFLSAHANIIDTYDGMFQTNDDSAFFFVQEFCPHASLREAVEASPGGIGETAVKEILSKVLSAVEFMHNENLVHRNLKAENILIFDKTNYSRVKITDFGLTRKIDSTVKYLEYVTSYHAPELCETVVNEVLTVKYSIDVWALAIIFYYCLKGRFPWQKATIMCKPYWEWEQWLKRKSPSLPKRWDAFSDKSLKLFKKCFTPKAKDRWSVKDMRKLIVKEKLLKQPKSENADEYVYYPEETSKSDKKVDESKAPKKRSLIQQWINTTLNTMAEISEQVVSARDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8G0</accession>
    <name>A0A914Y8G0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8G0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16484.t1">
        <property type="protein sequence ID" value="PSU_v2.g16484.t1"/>
        <property type="gene ID" value="PSU_v2.g16484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16484.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16660" checksum="B223585082BF9EB6" modified="2023-02-22" version="1">MSGLVTIEKTEAQWKHQASIYHREYGISHSVGSLDGTYIQIRNIGDRTNWICRKRYPAINMTIMVDASGLICYVSCRWPGSMHDSTVYRNTDLYRVANRPPPGRWEPFPGAVVLADSAYIGIVGDNLLLAHPRFRRLTAQNARFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8X5</accession>
    <name>A0A914Y8X5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8X5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1664.t2">
        <property type="protein sequence ID" value="PSU_v2.g1664.t2"/>
        <property type="gene ID" value="PSU_v2.g1664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1664.t2"/>
        </source>
    </evidence>
    <sequence length="338" mass="39678" checksum="3E31ADF18647ACA5" modified="2023-02-22" version="1">MSDDDTSSDSEAEFKRKIVLMQFVPADDSDECEIVDNPFSDNEDDTIDYNRYDTDKELQKLEPVARITRAYNIRGYPPYRKEEVLKDGKWHCRILDGENRIYETINQTKYIGFHLAAILFMKDLITDSESWMTQLGLPYDISRCNQILDDKFQELQTKSKEIDGIGGKDPKSFLTEFAVKSSKKAAETEVAKMFVQKLKEKDEIRPYLEDQAMLKRGKYFKDHVLHGHGSEIQKKFDHYFQDDPYHYATICNGGDPEIEVEKEKGEIILTCKGYSMIIKTKSIEEAKHEWAYRFLRKTFVDRSVPNFFEKHLPDEMISLLNDSFHEITIPEPWENEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y948</accession>
    <name>A0A914Y948_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y948"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15968.t1">
        <property type="protein sequence ID" value="PSU_v2.g15968.t1"/>
        <property type="gene ID" value="PSU_v2.g15968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15968.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14804" checksum="3EB9BAAC1964D3D2" modified="2023-02-22" version="1">MISVSDIATILINFYTSKVVLIEAWKPWFVANPVYGTIGWLMSGYLIYFQSIMHVTIALNRIWIAFDMQKKNNDAIERFTKIGLFLLPFLPFAILSVRFAGTTVYRFDADGEIYGVYVEARAEFDERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9A9</accession>
    <name>A0A914Y9A9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y9A9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15349.t1">
        <property type="protein sequence ID" value="PSU_v2.g15349.t1"/>
        <property type="gene ID" value="PSU_v2.g15349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000008">
        <property type="entry name" value="Beta-1,3-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="225"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15349.t1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53734" checksum="3BC7F0EBEBA7258B" modified="2023-02-22" version="1">MNKTLRLLFIFSFQLYFVEGTFLNVIILSQNIPFEDSLSQNLAAQFQNLKSDIKVNFLHKDFQAVNGGWTIWPLFRKLSANSFDWFLFIEPYTKIDGDKLIRFLENQNKNELLFFGYGLTDDHPVIIHHFYGYDKPDKLKYPDFGAGIIFSQALILKLIQATFSEQSAATSFAIDAKFELAKIVEFAGISLTTDIGFCLSPSPECFTWFEEPEYSKNTSACGKGITNDNTFLGIKTCSKFHKSRVVVTKRTWAKEAKYVEFFSDVPDFYIPTIDLGIANTEKGHCAKTFGILKHALEHEELNEVSWFIIGDDDSIISISRLYKLLNCLPKVSKLIIGEKYGYGFTFDGLGGYDYPTGGAGMIFSRSAARALVSFCQCPSDDSPDDMIIGMCARRLSIDIIHSAAFHQARPIDYSPAYLKRQKPISFHKHEEIDPYEVYANLLYERDEFLENQKQAKWTSQHSIPKSQHNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9C6</accession>
    <name>A0A914Y9C6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14146.t1">
        <property type="protein sequence ID" value="PSU_v2.g14146.t1"/>
        <property type="gene ID" value="PSU_v2.g14146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056053">
        <property type="entry name" value="DUF7636"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056654">
        <property type="entry name" value="DUF7752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057493">
        <property type="entry name" value="PH_RdRP-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF57">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24642">
        <property type="entry name" value="DUF7636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24934">
        <property type="entry name" value="DUF7752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25359">
        <property type="entry name" value="PH_met_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH-like" evidence="12">
        <location>
            <begin position="132"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="432"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="13">
        <location>
            <begin position="1040"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7752" evidence="11">
        <location>
            <begin position="1258"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7636" evidence="10">
        <location>
            <begin position="1401"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14146.t1"/>
        </source>
    </evidence>
    <sequence length="1512" mass="173584" checksum="A69DF330C0217B81" modified="2023-02-22" version="1">MIQCKLTFRGYAQNDLQKFEEMLIGHSLVNIEKLAKVSSLHYASDKNGLGEREESEYSLTLKEIPDDLAYLRKCAALAELNYILEEIQTEMKSTNLNQLDKHASVFFVISSSNIYPKNFGYVLGPLVSEKDSDAIQKFLHEQKGVENFEHAMAAVFENDQESFSVFLNDFYGYCQRVIELKIQYSAIRRIVANVNCLDGKLSTAVTFQLSFPPSVFVHRQNNDENADFQFFVRERYQTWDQRRIKTDDIALSTAFAMETLEVDAHFLLEVFDRLHKITGKFVQFQSLCLNPFVKHQFYETNFLKYPEKLPVDLQKLGNKKYYPLVYAIHALTSRGGEIYDHFFRRPYACFESFLKIVVQKYDQNLESESDKQITRTVRALELMLQKIDNLMDIPEPMSFFTSLYDQPEFNFASELTHDLIADGFMRVRKAIVTPTRVILCNPDVVMGSRSLRMSGGDKMMRITFRDDNNSKLSGVNKVLAGKIVENFLKTSQIFGLCSFSYLCSSNSQMKDHGCYLLAGSQENVVEFRKECGRFTIEAIPKMMSRLGQCFSQSRQSGIEIARNDYCEIPDFVGGADGNGNPFIFSDGVGIMSKDFAKQIAEDLGYSDFVPSCVQFRFRGYKGLLVIDSKIDESHEGPKYQYQENRGEDKFSNKKIFFRKSQRKFTGPREKFISIVKVSAPIVVTLNKPLINILDQVSEKQDTLTHSTIKSRIFSLLENNLDTIFSCFFDNNYAYLVLMGFPKYIPYQLFENFQITEEPFFRSMIRSSAFVRLNRLIEKMKIKIPSSHGRMMFGVVDESGILQQGQVFVRYTTNANLKFPPQCADKITHVGPVMVTKNPSIVGGDVRIFEAVDIPSMYELVDVIVFPNNGDRPHPNEMSGGDLDGDEFSVFWDTDLFLHHNEDPFDYTPAIPELPKNSEDPDFHNKLSNLMIESFKSYISLDSIGTIANSHLANSDLYGIDSQASVDFQKNGIMPEALTKQWRNGVPPEKVQTFPNFMDKTVAATYKSGRILGELHERLKVIKNVLKFEENVFDESSVVVDQTFVVPGDEIYYESAVAMYNNYSSLIQSLCDSYGIPNEGSLFSSNFVALKKRLADRDEDNTSVFTTQYMIEEQLANIYEKIRLQFFDQFGGLEMNTEIDDKNALGIRQAFSRICNAPTSELRKKASAFYRVAYDRKKHLSFAWSVADILMANRKLYCIRNPNIKFHSSFPLEDKLSQIINDATLKFAKEYHIFNRKMDEALDHEDSNILVSLPSAQVCRHNKGLRKLLFFIRKWSMKQNLSEISPKILDALLIAFGSGKLDVSCEPSITIPYYRDGPVVDLENQRGGLGKIFLNFFQQNLTQKFIASDVFSLLPFSKRILQKHQCLMLHYKAMETFYPIAVNRIFHALPGVQENESNFEDKIVEAEIFVIEMPMNVENYEELLKKLGEKCGCKYVTIKRKSEPRIGKKTIRVALQAVGTFWSAWKFRQTLLPTPNLNEPDFEQKNALLGVEAYNRLQFYTNEENSINDIYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA84</accession>
    <name>A0A914YA84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15677.t1">
        <property type="protein sequence ID" value="PSU_v2.g15677.t1"/>
        <property type="gene ID" value="PSU_v2.g15677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15677.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31628" checksum="7112FF783E65F41E" modified="2023-02-22" version="1">MTISSPMNAQELEEFILNPPTQLADPPALSNRLQDRWPSTVTQEPIGHQTLALETEKLSAAHVTGKINDVDTIFLFDTGSKASVILERQAQRLNIPITYNLPDIGLMGVGGQQFFTEGQIEATAKFGILEVPLIFYVMPEKSKYNPSFNVIMGEDSFKKLPPILYNYEENYIQIGTNVIEMMAVELISAGQDTQKSENETVKIEFGPTHATTEQTGQLFDLLNDYVDVISLSEFDLGRCTISASPIELVDETKPLASKPYRVREKAKEIIYNYIQNMLLAGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB87</accession>
    <name>A0A914YB87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16547.t1">
        <property type="protein sequence ID" value="PSU_v2.g16547.t1"/>
        <property type="gene ID" value="PSU_v2.g16547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16547.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14321" checksum="A9B72EA580CBBF14" modified="2023-02-22" version="1">MILVNRNDPTNFSIVAIPCLTEFSTLTGESINYSIDEELPGEFVDIYALHGEEIFGVILTSQTADQIIQLIWKLNKENERVECIVERRFSFKGVLNCRIGKIIHSFFVVIILCSAIFFSNYRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD20</accession>
    <name>A0A914YD20_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YD20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16638.t1">
        <property type="protein sequence ID" value="PSU_v2.g16638.t1"/>
        <property type="gene ID" value="PSU_v2.g16638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16638.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="11077" checksum="DD2C2F8E292DCCD7" modified="2023-02-22" version="1">MLKKYKTFGYTVIICVIIYFCWNKVKTKLEGNYLTITVKTAFRTHNTRVAQIVDSWFQLAPKNIYFITDAFDPVLQRKGQRNTYKYKLWLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDA5</accession>
    <name>A0A914YDA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDA5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17420.t1">
        <property type="protein sequence ID" value="PSU_v2.g17420.t1"/>
        <property type="gene ID" value="PSU_v2.g17420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011:SF6">
        <property type="entry name" value="HIGH ZINC ACTIVATED NUCLEAR RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17420.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24036" checksum="A63CE800E38244A7" modified="2023-02-22" version="1">MCRSCRHIKCITVGMKAESVQLNRDTIGKQSAASSKSKSSKAKKELSSDSAYQPSLPLTLTPISDDQTPTPPSTSPLSSAGLSQSSIPNIANNYEEAEWEISNKLNRVFEDAFLNPRTSTDLSIIEQFQIGYRHLCTKRPMIHQTRFIDFTAEMFQTLPENEIDRIFYTNWEALIKQHEVEIDLLAELMSFIRPFVELPKDQRWLLFKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDH8</accession>
    <name>A0A914YDH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CCR4-NOT transcription complex subunit 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1828.t1">
        <property type="protein sequence ID" value="PSU_v2.g1828.t1"/>
        <property type="gene ID" value="PSU_v2.g1828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="107"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="296"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1828.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51597" checksum="5303492D71C9BC4D" modified="2023-02-22" version="1">MSTDFDNDKDCPLCLEKLEVDDLHFYPCSCSFQICRFCWHRIKTDENGLCPACRQPYSENPVTFCPSIPSKTQPHSERKVKEKTKEKKKDIIDARKHLSPYRVIQKNLVYVVGLPQCYATEKLLRSIFEKHGKITNLIIGSLPSSYSDEPLNTAYLTYSNEDDALQAICDNSNLRLGARNIKVTLGTTKYCAFFLKAEPCTRQECSYLHEVAPREISFTKEDMQQGKHIEYEKDLIIDLYRSKNPGKYSPILEVRAIKPPTPVKPKMREEEKTKEKQQDIIDARKHLSPYRVIQRNLVYVVGLPQRYANDRTLRNIFEKNGEISKMIIGTLPSNFSSDPLNTAYITYVNDEDALHAICANSKLRLGGRNIKVTLGTTKYCAFFLKAEECTRQECSYLHDIAPAEISFTKEDMHQGKHMEYEHKLIFNLYRSQGVILSSDEMSSSYESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDK5</accession>
    <name>A0A914YDK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase FkbM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989:SF3">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989">
        <property type="entry name" value="UNCHARACTERIZED DUF13 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_21"/>
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    </dbReference>
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        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1738.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14862" checksum="E8B0ADD386B5E685" modified="2023-02-22" version="1">MKVVELTKLLDEFVESRFIHYLTIDIEGFEYGILRELIGNGQFAKAGIIICQIDAELHNPKFPNAHDSIKQLNPVRFILDFLDTPSPYIPIFNVPYLRHPHQKVSFVNIVNPECRRAFKIESYFDRK</sequence>
</entry>
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    <accession>A0A914YDT4</accession>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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            </authorList>
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        <property type="protein sequence ID" value="PSU_v2.g16922.t1"/>
        <property type="gene ID" value="PSU_v2.g16922"/>
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    </dbReference>
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            <begin position="40"/>
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        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16922.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16249" checksum="41AFBB7D93D68A98" modified="2023-02-22" version="1">MASLFFSLFNCCKSKSKKRLKIEPTTVSGIPDDPVAAIIITTEPEKEEDGRLTDESDLPKYNNDGFESEDEEEETDSETEEQDYRQFSGTKNDVSEDEREKMDTVAEIVIPPSTSDSIDLKSDYDKLLYSNATAQILMDLEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEG0</accession>
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        <lineage>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
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            </authorList>
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            <begin position="14"/>
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        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
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        </location>
    </feature>
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        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
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        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1865.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23221" checksum="DFEA2DA3EDB8A693" modified="2023-02-22" version="1">MNFLPNLENLYRNKARKAAESPDAPSTVIDEEETQIQDPDTVIDGNLAEAAHEIGQNIEGFYEPRSDFETDSHTVAGGQQPSTSSHHETASVTEPRQISRIQRILNFKKQQKVGPEPSQTKSPLSSIKESGVINEAFDMTSMNENVPKIINNSLPVARHLPPPASLQNPIFSMQPNQGDFVEQLELQDMPYDGSNDSENNNPAIVTVRSI</sequence>
</entry>
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    <accession>A0A914YEJ2</accession>
    <name>A0A914YEJ2_9BILA</name>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <lineage>
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            </authorList>
        </citation>
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            <begin position="193"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18684.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="22153" checksum="F7D389A79335EB62" modified="2023-02-22" version="1">MRIQHPVHAQQIAGGETDAADLLTTGIDAAVYLQAAAIDADINVACLHFIADHQVAFAQLERPATGNATGGKPGVQAGEVLQLACTHYQLAAVVGHFSATGVVAAAGSAKQRACQIHTAALRAQRSDRQAAAAVVAGGKIDARRRVGNDVTVTARQRYVAAPTVLVHVEQADLPPRHVQHCIAAKRHALAGIGFRTGRTPTPPGCRSQRVRP</sequence>
</entry>
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    <accession>A0A914YF71</accession>
    <name>A0A914YF71_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF71"/>
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        <property type="gene ID" value="PSU_v2.g17405"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17405.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="27785" checksum="8143C0A6E6C09D23" modified="2023-02-22" version="1">MVGADRGGVHVAHAVGQHGHARAFLAADDRAADAGAEEGALHAGQLGHGIAQGAGLLLVQALTGQHVHRARQGFGIALQRRRGDLHRRQLGQVAVTMRGVLAGSKGDGRHQGGEGEGQGMRLEPRGVGGHGHVPVLTPAPPARPFRCHWFDAVCRALRGDPRAAGGGAVAGPVVLAESMAGTGAGGVRDPARAVQPGLGLSPPRCAACARLPDPWSGRAVGRRAVRPAAPQRGATCGGDDHRRPAGGRCPSGQPAPQPRSRARRKLRALGPP</sequence>
</entry>
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    <name>A0A914YGP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <authorList>
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            </authorList>
        </citation>
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    </reference>
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        <property type="gene ID" value="PSU_v2.g17960"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17960.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20509" checksum="179DE43247781B80" modified="2023-02-22" version="1">MGGRLSDMESIKAKKTVSKAVSKEGKSKKNIKKAILKDDSSVKNYEIVKPKKRVRKPKEDIFDKSTETNGKKNKKDNPDESKTSGKKSKEEIPAKLKKSGKKSAAENQDKKRPLPKEDFEKPRKTVIKDIKDKTVKSAEISNNPEQDFLKTRTEIFPDGHKFQCNCNYGDWSEWYPHTH</sequence>
</entry>
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    <accession>A0A914YH91</accession>
    <name>A0A914YH91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH91"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18693.t1">
        <property type="protein sequence ID" value="PSU_v2.g18693.t1"/>
        <property type="gene ID" value="PSU_v2.g18693"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18693.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17090" checksum="064AF393CE2F7B9E" modified="2023-02-22" version="1">MYTFEIVIEASHFDFNAFGVQGGMVVIDDITYTAPAIYNCRYIPHIDPPIPISEETCKTIYCTFDDGKCIERIRSSGWRLSDEATGNLHTGIRMLQDKSFAYSKGIGTKTLKFGKFEMARQGLLEFCYYIAMKNTTLKIYTTLNGYNRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHF0</accession>
    <name>A0A914YHF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHF0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18893.t1">
        <property type="protein sequence ID" value="PSU_v2.g18893.t1"/>
        <property type="gene ID" value="PSU_v2.g18893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18893.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34538" checksum="33598D8B04F740ED" modified="2023-02-22" version="1">MAISINEKESLMPLTSPITDDNDAATSTSIDDDDDGSSLKDILQALYDSDKYKDLTFIVAKKEIHANELLVKIRSSVLKEKIEDPKREVPNGKIMLDDQNFEDFKKFLKFLYTNDCEITQQNLTGLFLLGKKYNVPFLCNKCLNIFNKFLNKNNASTFAAAALKNPDLAEMFQKCLELVPNVMESMSFFYVDKYGKVENVVAASFIQQILRQSRSENAEDALFAKIYEWAKYDCRHRGLKEESNNIKETMKDLLPYIRFGNLKPYTLATIVRSNNLLPLEELVSYLCNVAVKENQPDENSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI31</accession>
    <name>A0A914YI31_9BILA</name>
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        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g1898.t1"/>
        <property type="gene ID" value="PSU_v2.g1898"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR039303">
        <property type="entry name" value="CCDC50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029311">
        <property type="entry name" value="CCDC50_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22115">
        <property type="entry name" value="C3ORF6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22115:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCDC50_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1898.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29806" checksum="2E51B1612B2ED699" modified="2023-02-22" version="1">MQRRQSDIDRESVKDVASRLRQFEDHNLAIKLQEEEFNHHYNRNRSERKVMGVDTRKSKEEQELEKRYALEKRLAECREIATRDEAIAKQLQQDLEAEERRLKQEQDLLDQEIARRMQSRYEPPPIPSPTTYEEDERLAREMHERYLRRMRGLATAGSLDDRTRNDLIQQQQIISPPSSLQPRQSTFPDELGPPSLHFPATHFPLSPTMPPSTINLPPLPSYTEVCTPTTPVLTNTMSSSGVFLFILFYFNFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI69</accession>
    <name>A0A914YI69_9BILA</name>
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        <submittedName>
            <fullName evidence="3">ShKT domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
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    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g19010"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037645505" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19010.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9253" checksum="8DD8AED9FD25EC1B" modified="2023-02-22" version="1">MKTTIFLATLLFISFFTLSFQAAAECIDRGIDCWCKAALCRNAAYETLMTRQCCETCARVTGAAAGRRRRRRNVSGFDQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YID9</accession>
    <name>A0A914YID9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YID9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18582.t1">
        <property type="protein sequence ID" value="PSU_v2.g18582.t1"/>
        <property type="gene ID" value="PSU_v2.g18582"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18582.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8801" checksum="AF3F79A781B18F8C" modified="2023-02-22" version="1">MIGGFMINYGVVGVGYFGAELARFMNMHDNAKITCVYDPENGENIARELQCINMSSLDALVSIMKIVWIWSKRVKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIK8</accession>
    <name>A0A914YIK8_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19140.t1">
        <property type="protein sequence ID" value="PSU_v2.g19140.t1"/>
        <property type="gene ID" value="PSU_v2.g19140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19140.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11341" checksum="6719813E48A08910" modified="2023-02-22" version="1">MTNLQRPQRKPLQEYYNDDDAQLEALTKLIDPNAPRPTGQMITPARGDFPVAMTAPNGIRSTASAKSFEAVLERHSQVQPKVNCSTVIDHTGKLSTSLTYGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIP4</accession>
    <name>A0A914YIP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18696.t1">
        <property type="protein sequence ID" value="PSU_v2.g18696.t1"/>
        <property type="gene ID" value="PSU_v2.g18696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18696.t1"/>
        </source>
    </evidence>
    <sequence length="930" mass="99239" checksum="0E5798B9494B07C8" modified="2023-02-22" version="1">MEAIPSTMQNNVTSNTVAAEEEEKKRKEAELKAQAEEQERQKQFAAEEEQKRKAAAEAEAQKQQAEEEAKRKQQTAELEANFKANLDGLVSKLNEYSKSVETLRAFKMKLMQNTKLNVEFDAHIEPMLKSIGYVSIIGNDIDESLRRLRQVSNSIQRSAKESQQFLLKDSQELPTPEWVLELSDDLEELDQREFIVVEKLQQAEEKMEKISKLLKEGKAKFVPRNQLTPEQQQKLEKDSKTMLIFVRKLWERIKIIRHHVRDMNFDQKIMQAKQAIRSAGGEKNVSILNESDADFDTSDNNASMLASELIASISLVDKTNGGTSEPVKNNVQNLLKYLDQSSSRPPKLVNVVPIDQFVSTQKLKKTPPDSAILKPKVAEATKNLIEHLMKVQSPRAIIQNIPAAPPRQPLTLFDNKAAAPQQKNLFGTCNIPVVTPTSADPTSSPLGSLSTTGQKPETSTSKLLFSSNTAFTPQQSASPLFGTPLTSSPLATATTTPKIDAEEQKRKEAEEEQMKKDTAEIEAKKEAQEEAEKIKKEADEKAKKEAEEQERLKKFEEEKQKAEAEARAQAEEKKKAAELEAQKQAAAEEEAKKEQESTAPSNASPVTFSFKPAAASPTVVSAAAPTTSVNFSFKPETTTNVISESNAHIGMEDDGLDSALAGTNICSPTNTGNAFGSGTSGGGFSSFGGNAFGQQPAAKPVQNNPFGGFSSTATTAPANGSPFGGTLTFGATVKNPFGGGTTNNTGFSSFGTKPSAFGGAFSQQQQYSATTSATPQTNPFGANSSAFGTGISAFAQTAKSPFASAAASSTTGSGFSTFGNKPFGAQNSSSPTQNTSAFGGTVAFGGGSAFGSTTSPFASAASGSAFGGSAFGQTTKSPFAAATNSATFPTTASAFGGGGGFSAFGNKAGGFGALAQQATLNNPQNNSFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIT2</accession>
    <name>A0A914YIT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIT2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19214.t1">
        <property type="protein sequence ID" value="PSU_v2.g19214.t1"/>
        <property type="gene ID" value="PSU_v2.g19214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19214.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37268" checksum="2A9A6DB8AB4ED175" modified="2023-02-22" version="1">MVGKSKILKNSLVECVYVSTVQPVEYSCLSSLVSSFSPHSSLDEACKNFGFYSFNEYLRRNHKLFDSFLTLFVCKNPDVKDNENPFILYYYNTEGEKNSKFRSNFVEHQSVDLLRVGISYKESIFFESHNSLKIIDRRKEFVQLVEYCQTQGRINAGEMVPLDKIKQAFRQKYGNEELSNKMETWFPNRGSGIENIVQKVLFEDLNFTLSDQTNRKEIEFRLKEGWTEKNFDQHKRDLQGIKDKIECGLSLKNPTETAEDSKYNDMDAMHRFLSVPSQKPSGIFGCSSDEEDLRVENQPFKEGSTRKPYNGIKTTQRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJI9</accession>
    <name>A0A914YJI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19687.t1">
        <property type="protein sequence ID" value="PSU_v2.g19687.t1"/>
        <property type="gene ID" value="PSU_v2.g19687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19687.t1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50962" checksum="9DD42B5DB58B86D9" modified="2023-02-22" version="1">MSNEMFWINSAERILENKVTIKEYISAKIDIFLNTSTLTPYRVLTRCKRSEIEELLLNLYLNAPPGRLAEYVWNHFENTDSTKSELVKLSMLLASIGEEVDKNRELLINEEKRSDEVLPLFEKGKSQLANEFTNETIPNHQSIEVINNLFPTNQKIEPSAFGESDDYPIPEYLSSSASDVHHLESSYRFAPYRRTRRALLNNSMFGSSSSNQSSSSAAPMMVIIPRPSGSNASFEKNFINAKSTPVENIRRSERQYSSTSRVTVVDEKNMEEKEEDSFQEVPTNSSAKTNDKNSVKQYPSEKPRRKCAVVGGLYNIMNGYHTTIRRIKEKLEKPELSFDQIEKHKAELNEVKNNLQKGVLQRTLNNKAKKHFSPVMYQRLLDGFVTYEAAVEFINHENCDIRAIMQIVMNETVANNSVFWTNAMYSRGKWVTAALRKKHMLSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK22</accession>
    <name>A0A914YK22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19877.t1">
        <property type="protein sequence ID" value="PSU_v2.g19877.t1"/>
        <property type="gene ID" value="PSU_v2.g19877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19877.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18501" checksum="0B307DB244B4C769" modified="2023-02-22" version="1">MSRMSNGDIDEFRTAFQHGCPKFLSPTTVVFEGGNLAKEPLIRQSNAFLEGIENQIWLPILRGYLKLYTTLPLKKLANFMDVEEGDHDSFIAKLLSFKMIVNELGKATIGGGDAEDASMDLDFYVDKDMIIVADTHVARRVSEYFIKHITKLQDVTRKIKQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKD5</accession>
    <name>A0A914YKD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YKD5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17773.t1">
        <property type="protein sequence ID" value="PSU_v2.g17773.t1"/>
        <property type="gene ID" value="PSU_v2.g17773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF75">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17773.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12021" checksum="355A9BB1559BD522" modified="2023-02-22" version="1">MVGTSSWKQQFSEALTVGIDEEDVPDGPPHKPSILQFIIHYIALPWKLLFSLIPPTDYGHGWLCFIVSIFFIGILTAFIGDVASHFGCTIGLKDAVTAITLVAMGTSLPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL31</accession>
    <name>A0A914YL31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL31"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20058.t1">
        <property type="protein sequence ID" value="PSU_v2.g20058.t1"/>
        <property type="gene ID" value="PSU_v2.g20058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000001">
        <property type="entry name" value="Aldehyde-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF102">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20058.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20425" checksum="7B1E8906EE5790C8" modified="2023-02-22" version="1">MVHAIEAYTSRILKNPLSDNLAKQALRLIGSKLVHVCRNGQDAEARQDILLGATLAGQAFANAPVGAVHALAYPIGGIFHVPHGLSNSLVLPHVLRFNASAAAPLYAELAEVLIPGIQGDEASKTEAFINFMEQIAIDTGIERQLREVGIKESDLRRMAQEAMKQTRLLGNNPRDVTEDDAFAIYSAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLH2</accession>
    <name>A0A914YLH2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RUN and TBC1 domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small G protein signaling modulator family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1975.t1">
        <property type="protein sequence ID" value="PSU_v2.g1975.t1"/>
        <property type="gene ID" value="PSU_v2.g1975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="132"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="516"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="7">
        <location>
            <begin position="591"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1975.t1"/>
        </source>
    </evidence>
    <sequence length="817" mass="93163" checksum="F545E4995CB9961E" modified="2023-02-22" version="1">MAKYKKGTSAKFADSAVEDDDIDSEIFETNEDTLPVTTLIFNLNGKPFSAVHRQTLPKYFVEPKELLVYKSLIPSFNVDVFEECELETSQHRMKWIAHIQFTHEKVDELKWSDVDPQKLRSDKLNQLLHTNGIPHSLRPFLWAKFSGGTKKQKNGACSFAKIYERSLRDSSASVDGQIEKDLLRTLPSNLCFAKPDAPGIASLRKVLKTVAFMYPELGYCQGMGVVATTLLLVCGEEQTFWTMCSLIEDILPPSFYSHSLLGVQADEKVVKHLMCIHTPKLVELIRTTDVDMSMITINWLLTIFATAFPLKVVLRLWDFLFIEGGVTVFRFILAMLKMREPDILLASQISDHSSAEIFNAIAQIPSTISDPNGLIDYSLTFEDSITPQTIASLRKKYQGQLMADSGMIFEAPTSDGNLPKQKMAKRHIPRSKSFLPNIFKNSEALILDDEDDENDPKTKNIRQTEMIVDLRNSVHQICRHFTLCNEDHEQQINMQADYSLESHDKDCEVFLRARREGRKRARALLDFQQQEEDELGFYKNDIINILSEKDEHCWVGELHGERGWFPAKFVEIIDERGKNYCAFGDEAVQPRIGEIVRGQFSQAFFKLLNHGLREANIIAASFVSHPWPFIEALSAAIVESKTKSVNSKLMLCDTFKLDQDGKVLSPEELLYRAVQDINHSHNGVGAQLDVKLRSLIAFALNEQCLHLWFEMLCASNQQNTIRERYYHSYAFLRSPAWKQIKCELRLLSQFSFNLDIGAEILDKIICPSSALLSGSSSKKSFRKTNSMDVSMNTTNKQPLKEGVRDMLIKHHLFSWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLI9</accession>
    <name>A0A914YLI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Autotransporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2042.t1">
        <property type="protein sequence ID" value="PSU_v2.g2042.t1"/>
        <property type="gene ID" value="PSU_v2.g2042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.130">
        <property type="entry name" value="Autotransporter beta-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005546">
        <property type="entry name" value="Autotransporte_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051551">
        <property type="entry name" value="Autotransporter_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006315">
        <property type="entry name" value="OM_autotransptr_brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003991">
        <property type="entry name" value="Pertactin_virulence_factor"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01414">
        <property type="entry name" value="autotrans_barl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35037:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35037">
        <property type="entry name" value="C-TERMINAL REGION OF AIDA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03797">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01484">
        <property type="entry name" value="PRTACTNFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00869">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51208">
        <property type="entry name" value="AUTOTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autotransporter" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2042.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22449" checksum="1BF3B52410A75840" modified="2023-02-22" version="1">MNDRSGQVDQDSQTAYIYSSAHFANNVFVDGSLSYSHFNNDLSATMSNGTYVDGSTNSDAWGFGLKAGYDFKLGDAGYVTPYGSVSGLFQSGDDYQLSNDMKVDGQSYDSMRYELGVDAGYTFTYSEDQALTPYFKLAYVYDDSNNDNDVNGDSIDNGTEGSAVRVGLGTQFSFTKNFSAYTDANYLGGGDVDQDWSANVGVKYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLZ1</accession>
    <name>A0A914YLZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLZ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19932.t1">
        <property type="protein sequence ID" value="PSU_v2.g19932.t1"/>
        <property type="gene ID" value="PSU_v2.g19932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19932.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20994" checksum="07787B29CC6C3669" modified="2023-02-22" version="1">MSGPVREFAYCIYNNHSEALKTALLDIASAVIKNESLAEREQLCKPPHTTIVYDLYTCADNIKPSTELSEIFHALVYFPFRAICTYERIIYTPDLKIALTNCTECPEIIMKLSEIIMGHRKPTKEDECLPIKFAKAFRIAFAETAAIPEMESIDFDLIQELVRFYITMQAKLPFASYLDCYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLZ6</accession>
    <name>A0A914YLZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLZ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21350.t1">
        <property type="protein sequence ID" value="PSU_v2.g21350.t1"/>
        <property type="gene ID" value="PSU_v2.g21350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001822">
        <property type="entry name" value="RAB family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21350.t1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49104" checksum="1D39E0954491FC2B" modified="2023-02-22" version="1">MNKKGYIVKEDLKQLDGLIPNFSPNDLEQQFYREEDNKKKFMVNRDNFVRAIKPFLLKQNKSTPKQKKRPVKVASKAMFRTISLDTDETKQQPKPISSEAKPRIRLPKLSISLDEKLGNTDFINLRNPSSIPKDLGNESIYVQQEARPSIDSDDYDSIPMNSPFYDRTFSIPEDNSSAITTLKKRPEEHDEEIEKRNHNEIKEMLKKSKSSLEIKPTKLERPCNFGPTSLLEHPVVADDVKTPDRIFKIVFVGDSAVGKTCFLHRFCHNRFKPLFNATIGVDFTVKSIKLVDRLVAVQLWDTAGQERFRSITKQYFRKADSVILMYDVTSEQSFLNVRNWIESVRIGVGDCCVLCLVGNKVDLAANEAGRKEFDMLFFETSAYTGLGINDCMKAVAIRLQQREDDQLEEALRLEMIIQNSKRSWCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YML0</accession>
    <name>A0A914YML0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914YML0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21570.t1">
        <property type="protein sequence ID" value="PSU_v2.g21570.t1"/>
        <property type="gene ID" value="PSU_v2.g21570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21570.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24198" checksum="177F1B1EF791CFE4" modified="2023-02-22" version="1">MGARHSVQGQGQIDRRPRSNSVMESNLQPPGPTRRTISHIQTRHNSERDLSDVDPEEDEGSNNLGGNNAGPSSHTIHGNESSNFRVSMRTSRGLAGLLQQASAAQAAAAASAASNNRTNNERRTLLRLLAGRDVECPVCHKRVPSDDVEVHLVMCFTRPKLVYNEEILTTDRGECSICLDDMEIGNTVARLECLCLFHKSCLDEWFKRKNVCPQHPGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMW9</accession>
    <name>A0A914YMW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMW9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20939.t1">
        <property type="protein sequence ID" value="PSU_v2.g20939.t1"/>
        <property type="gene ID" value="PSU_v2.g20939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20939.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38900" checksum="52AFA64EFF6F9BD1" modified="2023-02-22" version="1">MLGVATSKDAKNSEYQAVADLLKKNTLKDWKKKNEKLNELEGMLMTASLFEAFEKHIESDDNLEPCDSPHCIVYKTDSNLPFNPTFLCHICSRNFHHCCIWRNKCPCCTTTVPSEEQSLKRIETEKKKVDVALKKLQNQVIAEEKEIQKFILEHKLGPLGKYVEKTLQKYGGTKQPFFQQYTGQQLLKMGNNIDKIVQELPAELKEDAKFKRIVAALNLFLDLKCRMSGERPNLEKVDAEMLHFVNYMKKYLPEENVKQLGHYWIIHGPEFLHEFETMTPFSDEAIESGHPVVHKYDARVKTRDQEDRLTWIMKCCAEDNKIFDSVACEKSKNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNJ0</accession>
    <name>A0A914YNJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNJ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20533.t1">
        <property type="protein sequence ID" value="PSU_v2.g20533.t1"/>
        <property type="gene ID" value="PSU_v2.g20533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20533.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11143" checksum="B5FCA1AF8FCDD6FC" modified="2023-02-22" version="1">MFCHAGVRRRRRWCELIRIDSGQRKGSLQIAAQTQQHHLLTFRWSPPCAGITRAQRQPADPVGFKVARFHPTKPVFPVHFGDYTYADQIGDKAHDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPU6</accession>
    <name>A0A914YPU6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Guanylate cyclase</fullName>
            <ecNumber evidence="3 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 16"/>
    <dbReference type="AlphaFoldDB" id="A0A914YPU6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2844.t1">
        <property type="protein sequence ID" value="PSU_v2.g2844.t1"/>
        <property type="gene ID" value="PSU_v2.g2844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000023">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF495">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="517"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="860"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1111"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2844.t1"/>
        </source>
    </evidence>
    <sequence length="1131" mass="127520" checksum="D7B8AD4012A7CCCB" modified="2023-02-22" version="1">MWRYLLLFLSHFFIINVRLKVGLLFPNATYRLRTLMGFGQSAPAITLALKRVQEERMLPNVNFTFVWYMDQCDEGKAAGYTTRLIQNDGVHAIIGPPCTTSAIISGILGSFYNLPIFTWGAATSSELTDGVRFPTLANVNANTFSLGQAVIEIMIEYGWSEFALIYTLDSEQRKCDFLQQDLEAVSDKSEETYISFKRQIGAEKSALLSILDTLKSRARIIVVCFDDDDTKRRFLVAADEKGMNTDEYVYIFPDVRSQGMLRQDTGKNADAVRFWVDYNNPPDGLDDKAKATARRSIIIDLENQSTEEIETFNKEVQSLMGQYPFFVMVHPSVYVRSLHDATYMYARAVNKTLQSYNPDQLLNGSLVNTLSRGEFEGMTGLVRINENGTREPVFFVTALSLTDEPTVYARISIQSNIVSFVPEYQDEFTTIWSSRNNKRPLSVPICGFSGVQCAVSTTGYIVIGIGGGLIVLGLFIGAILFIWRAKMLEEKKMNAECLVSQQDLTKLSADLQKSDLIKSMRSMQSGHSSLTRTTAENHEETEHHAFFLWNKEIVFGSKKVVRPKFGRQEFNIVRKIRQFDHDNVNRLLAVCLDAPVFMVIWKYASRGSLKDVLAKDNYLSDSFFIFALMRDVAAGLSAIHSSFINVHGALTSECCLINDRWQVKISDYGLSFLRTVEPIPKKRYLWMAPEHIRSDDKIGSQVGDVYSFAIICSELINRRPAWNYPDREDEIDDIIFAIKRSSEPPARPEIDVSDDINTNLLHLIRDCWDENPVKRPTMNVVKSLIKNMNSRGKQSLMDYVFNMLEQYATSLEDEVEERTKELVEEKKKSDILLYRMLPKQVAEKLKLGNTVEPESFDMVTIFFSDVVSFTNLASKCTPLQVVNLLNNLYTTFDSIIDGHDVYKVETIGDGYLCVSGLPHRNGDLHVKEISDMSLAFLNILVDFRVPHLPNERINLRIGFHTGSAVAGVVGQTMPRYCLFGDTVNTASRMETGRIHMSNTANDFLTKTIGGYITEPRGEVIIKGKGVMETYWLIGKADGTSSIPKPPHSNSIDVETPGLNISQPHFPEISPLVPSMEYRANAPEISSDHPQPPTVSFNLDKTITSKNSFIKTLPPNIPPPQHRSDTPSTVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPX9</accession>
    <name>A0A914YPX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21078.t1">
        <property type="protein sequence ID" value="PSU_v2.g21078.t1"/>
        <property type="gene ID" value="PSU_v2.g21078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21078.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10430" checksum="4B5992C5EC435A64" modified="2023-02-22" version="1">MVRLSVRQAPPNNAWVPQQDITVTQPNAASQVKVKSEPEIQVKAEVVSRAPGGNVLGEEIILGDTDDEDDQAVPDNQMEQLFGRLESPPETPPTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRX7</accession>
    <name>A0A914YRX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRX7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2928.t1">
        <property type="protein sequence ID" value="PSU_v2.g2928.t1"/>
        <property type="gene ID" value="PSU_v2.g2928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2928.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11991" checksum="7037559623669AF2" modified="2023-02-22" version="1">MNWTQGEQYCQAFGAHLASIHSYDEIHFLGSFVYTAHMALWVGAFSNDGGNSWEWSDRTPWDFNPWSNGYPNMHANACGILWDASMGDWTCNNIRQIICKKPLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU24</accession>
    <name>A0A914YU24_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="AlphaFoldDB" id="A0A914YU24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3648.t1">
        <property type="protein sequence ID" value="PSU_v2.g3648.t1"/>
        <property type="gene ID" value="PSU_v2.g3648"/>
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    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:adenylate cyclase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:detection of external stimulus"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:response to temperature stimulus"/>
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    </dbReference>
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        <property type="term" value="P:taxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000941">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
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        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF498">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="315"/>
            <end position="445"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
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            <dbReference type="ARBA" id="ARBA00023239"/>
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            <dbReference type="RuleBase" id="RU003431"/>
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        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3648.t1"/>
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    </evidence>
    <sequence length="503" mass="57041" checksum="B7EF59B68E22143A" modified="2023-02-22" version="1">MKQFVHDNLNPFLGMAFNEKDEMLLLWKFCSRGTVQDIIYNDDVNLDSKFHAAFVRDITMGLEYLHVSPIGYHGSLTPWSCLIDRNWMVKLTDYGIAAPLEKWEKQGSISKESLKDNEDKSGASQSGSLLYQAPELVKNRETNRRRGAEQQWLKQTQNRRQAGDIYSFGMVMYEILFRSLPFPDSTSNEDIIGFIKDGSKTYKPAVQDRSAIHPDLAALLQDCWSENPEIRPSIRRVRLNTESYLKVKGSLVDQMMRMMEQYANNLEKLVQERTGMLEDANKRADKLLSQLLPSYVANELKLGRPVPPKTFKHASVMFSDIVGFTTICSSSTPIEVVTMLNAVYTGFDDVINRHEAYKVETIGDAYMVVSGIPIENGIRHLMHLSDVALEMMKFLQDFEVPHRKSQKIRIRLGLHTGSVAAGVVGLTAPRYCLFGDTVNMASRMESTGVPEMIQVSEPFKINLNQHYPEFKTELRGTVEIKGKGACNTYFLDKPPKTVSPNPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU58</accession>
    <name>A0A914YU58_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
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            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g21000.t1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21000.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11655" checksum="D6C208529D2F7A1A" modified="2023-02-22" version="1">MKESNLRQKFGNQMEELLDYFESTCVSQLNADGSRRAPRIPVAYWNVFMRVVNDTPKTGNSCEAWCHALKNSLPNPGIWRFFEVMKEEFTLLPLSTRFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU98</accession>
    <name>A0A914YU98_9BILA</name>
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        <submittedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <lineage>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
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            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU98"/>
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        <property type="protein sequence ID" value="PSU_v2.g3565.t1"/>
        <property type="gene ID" value="PSU_v2.g3565"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3565.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11816" checksum="5467CE1031D9A7FD" modified="2023-02-22" version="1">MKPVASSSSTSSSPAVSPSGHRCLRKSKKQRQRKQTLDILREMIGCDKNVSALELIQLIMDHINHLQEVLAEDNLDETESNSNADTVQALLRQLSLSTYHANISKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW52</accession>
    <name>A0A914YW52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YW52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4347.t1">
        <property type="protein sequence ID" value="PSU_v2.g4347.t1"/>
        <property type="gene ID" value="PSU_v2.g4347"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="3"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4347.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9896" checksum="7AD5322F12850F0D" modified="2023-02-22" version="1">MECENEKDDRGEFLCTEWARSGLCEAHRATMFLFCRKTCLCTGPPKDDDSSESDDATRRRRRRRRSAAALKSFKSHFKNYKIISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW55</accession>
    <name>A0A914YW55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anillin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW55"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4799.t1">
        <property type="protein sequence ID" value="PSU_v2.g4799.t1"/>
        <property type="gene ID" value="PSU_v2.g4799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF24">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anillin homology" evidence="3">
        <location>
            <begin position="729"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4799.t1"/>
        </source>
    </evidence>
    <sequence length="979" mass="109412" checksum="7422BCE8D93F2A04" modified="2023-02-22" version="1">MDSTSEYLFRVGRRDKMLGDLDSSVMSEIDEHENSDGSSSPSVPKITENSQSEKADTNKPYTNDSEDIPAIDASTTSSSALRSPLRSVNKIPTITLQDSPAPTSPLKAKFAKLSQGYQNFEVDIKPSKTKEDYIRGPVKRISMGGEPAAADFFAPKPHGSTSSATSENNSPALPPEHHHAATTASGATTSTPKSAALPVNNLPLSPFSHHSSLNTSDANETFNNTSMNGIFSFGRKILNEPSIEKIDEAPFSPVEVKPSNTRVSPQPTLPFIGKSTSGESVASASSSKYGHKVNDLKKKFDYPKSGLIPGNTIDTNRMDFGKAKSIFESAFRPTTRYQSPYAAKREQGVTNIRRYDDPNPTKKPAHCEIVSGPTFKQSVNYWQDREREFPSSELVDAATQIFKGPTKRENSKNENLFYSSNQQPSHRNETTSPSPKVTKYYDPPPQTAMEQARKLVSFADESDAEAAKNSSLNNEKKFGVKPLVITESFTAFSTLASSKKSESVASFSVPSDSFDYQKPLSKDASHRENDDPLSPLGPSLLDDINQDFTKAHTPVSHKVSSRVIGEDGGSAAKPGLVYSLSNYRKTEATPQREKIIYDNSKDVVNEMMASEMKSVNEMVRKIPHDEIKKKLKQLEIAQTVANNQIQQTEKALKVSRHTNNKSSYPNYNQEVELLQTLQTIIERRRACCLEYGRLSNVSDPYYIFPRATIRFTKIAVEVHRHLDVAPHHYAYLFALVRYNEQVVSSQALFINPTISQGVGSVEFCDIIEIEDVSPDFSMSIDIYGLTLVRKDSKYDTTRFNLKRMVSSPQPERSNQSEIFGQIGQVVIDREDLTKKVLELSTFETPLAGHCRINFQAKISDIDDNKWSGFVSIYRVVDAKGAWELCYSNINNNRLNFWRYPEDADTKPPILSLNIRDMSELARPCCNEKLGFQNDFEVKIIDASENIIQIMLSTAEERDRDRIIAAINRSYKYINTWRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWP7</accession>
    <name>A0A914YWP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4529.t1">
        <property type="protein sequence ID" value="PSU_v2.g4529.t1"/>
        <property type="gene ID" value="PSU_v2.g4529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036929336" evidence="2">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4529.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23074" checksum="E147E6CC1CFEE6E0" modified="2023-02-22" version="1">METFIFLLKSVVQLFAYQPPPEEIPKLPEIIYNKIKQPKCRESIADFKEDDGRREGFFCADTMSQKREKRRVSLRPMEDTISEKDEVESPLPNSPKEKPILADEPATNKRRQFAARERFRYSINTMAHEQSQRVKEPCYGFRASIDNTSLSGPLQTNRASVISIGQHRTSNPRVRIVLEDSPRRRPSILMRYNSAIGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWQ2</accession>
    <name>A0A914YWQ2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="9">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Tetradecamer that assembles into a two heptameric rings with a central cavity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914YWQ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g251.t1">
        <property type="protein sequence ID" value="PSU_v2.g251.t1"/>
        <property type="gene ID" value="PSU_v2.g251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g251.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27064" checksum="29EF45A59834F62B" modified="2023-02-22" version="1">MLQRNCRFAQLISKSLIQLEKNAVAKSFHLSSTRNFGIPLVIDNDGRTERVYDIYSRLLKDRIICVMSPIDDHVASAIIAQLLFLQSDSSKSPIHMYINSPGGSVTAGLGIYDTMQYVSAPVATWCIGQASSMGSLLLCAGEKGMRTALPNSRIMVHQPSGGAQGTASDILIRAEEIIRLRQRLNEIYSTHTGQTIEKIHETLDRDRFMSSQEAKDFGLIDRIEIHPGSIPSDVTSPGPVKPLVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXC3</accession>
    <name>A0A914YXC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5158.t1">
        <property type="protein sequence ID" value="PSU_v2.g5158.t1"/>
        <property type="gene ID" value="PSU_v2.g5158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5158.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15373" checksum="FAD63E5A62467927" modified="2023-02-22" version="1">MSDFDKRMEFNIGIDTSDDENEEEGFKLLEVKSNFGNTQNSASKVITDKNDRTEDVVVPKMDSAPNINLSSENKNDSKISCYEIIFYIFVIIFGLLHFVLAFALIYDFEKAQKFMFYLILGWILIAYIKVIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXI5</accession>
    <name>A0A914YXI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPAR/Ly6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXI5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4673.t1">
        <property type="protein sequence ID" value="PSU_v2.g4673.t1"/>
        <property type="gene ID" value="PSU_v2.g4673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4673.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8579" checksum="9E01EAFA68C1250D" modified="2023-02-22" version="1">MNNGINYSNSSKGCGNYITWNENGNQGKCLKSGGLNFTQNGLTGIVSCCDTDLCNSATSPPSIYSFIAINVLTIFSIVFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYA9</accession>
    <name>A0A914YYA9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YYA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g305.t1">
        <property type="protein sequence ID" value="PSU_v2.g305.t1"/>
        <property type="gene ID" value="PSU_v2.g305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF11">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="5">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g305.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14660" checksum="957AD16F1B1F6226" modified="2023-02-22" version="1">MNRNDIIMDMMMQPEHPSYIRFVERGETSLPEFWNDDARSRNHDMMGHILEWMYSELLGIKSACKAFKEINIAPFKSERVKHIKGVHHSVRGEIGVEFAHSDEEIMLNVEIPANMTATLHIPLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZA8</accession>
    <name>A0A914YZA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZA8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5431.t1">
        <property type="protein sequence ID" value="PSU_v2.g5431.t1"/>
        <property type="gene ID" value="PSU_v2.g5431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5431.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43370" checksum="D885434C2417BD58" modified="2023-02-22" version="1">MPMGPPGRQFPPQGGINAWPQQQQQQQQQQQQPQPQQSSQHQIPPQHPHYPQNLAHRQQQQARIRFQQHQSSIPNNNPNIPNPVSAIQYARSGFQQRPPMMPMSSSSSTLLSHPTITKPTIKKVKNPTVEKEKIQTWHDYPADKRQLKKHRFAPDVFPQDPQQEEDKMTPERIKRGFSLSHNHEGESAMKHFIIREDKNSGGEKGGGGGGSVDKVDEFLHKAAVFIQSVSQKKSGLLDNKKINSIQFYIYKDPQKKSQWFDDLVKGKSYNLLVKKIPLLETTEEWLEEAFEHKISIPHVVWLLKVSHFGAQESQQRQEKQQISKSKKQMESCDYTFVFLRLIKDLFDKMEDETTANLAKQKWKYFSMLIRHSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1I2</accession>
    <name>A0A914Z1I2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1I2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5977.t1">
        <property type="protein sequence ID" value="PSU_v2.g5977.t1"/>
        <property type="gene ID" value="PSU_v2.g5977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF10">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="489"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5977.t1"/>
        </source>
    </evidence>
    <sequence length="601" mass="67243" checksum="3E01DAB22D5AF938" modified="2023-02-22" version="1">MPTTTYPFVPQRTTTTFDRIVKQFNKKILADSSTERRHSRILLAPIDRVDVLTSEDYSQYDVVNGVPNVAVDKDFDDNNFEENKNKIPRLVTLPKVKKSIYDQSQKNDEKPRKVQQPRAGGFKGQSFISEIDPNQHRTTMAELHFDTTDTLPTTTTTTSSPPLTSTRRLVTLSSSTIKSGYIRIKAQPRAALNGTKNIRTNELDSLTRISNTLQSIPRPQNDKRFPAEKWQIPPSILNPGQLQQQDDNRPRFLLSSSSSSSASQLNDYDTQRPTSFETYPSPPRGYQEPTRYGPRLNQGFIPQQPPPAVLPLGLLSPETILTPFQALTAALSPSGQSFLPQPRPPPSSYPPVSLPSARSSNHSHLQFRSNGTPKYHATFAKHNDVIQPIPLPLTGFDENDMDLLSPNNNNNVRQLPYQQLQQQQQQQQQPPQPSSLSADPMPIPLSAGAVPISPVTTTFGQQHGRPMAVESGAKSRKTNLEPNAKLQLCCQKQGLSSSCQNLCNFDTFTDKTLVSTFLTNQCPEPQRALAFQCATTNVDHSECCRRNNLHNYSGGQCMPFCTTHIPTPPNVFSYLQCLQVFDTIKNCYREFQYTNPNIFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1M2</accession>
    <name>A0A914Z1M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1M2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6014.t1">
        <property type="protein sequence ID" value="PSU_v2.g6014.t1"/>
        <property type="gene ID" value="PSU_v2.g6014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="413"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6014.t1"/>
        </source>
    </evidence>
    <sequence length="1099" mass="124628" checksum="A6D06BBE33926BBB" modified="2023-02-22" version="1">MFVCKYCRTSAPLIRTINQHLQSKCFYVDADEYATYLAGPVKTRKPLVPLRREPVITRSRSNSFSTPNQVSQPLPQTPVMAMEIHRLNSIIEVNDNPCFLPELSETSSSSSSSATSSPSSKSSFDEQFFDAPQSPFANHFAERIVSSVVNEEPDCWVEPDAWVDTVTNEEPEQINHQPLNINEALEDPLVAFDPTPQNFNSCFNIGTFEKLHDSLIIQLQELQENTKKSQMDRQKDKEQTQDRQNAAPPPRETSATFDAQRSQSPRTAFMQRRSSKKNVNKHSFKSSKYQHTKADYQKLQGLYRVNRKKAFNQIVQDSETKTCEIEENIVVDHFKNVYAKSDRQPTPPPECVPDYPHIDEDDSNPLGTAFTTSEVYEALKKCTNSAPGPDSITYATIKKYDPSASILTAVFNAVKRLKHIPQAWNTSSTILIFKKGDASDIKNWRPIALSNTLSKLYASTIAKRIQSWAIRNKVISSSQKGFMPFEGCLEHSFEIQTIIQHAKRNRKEAVIAWLDLYNAFGNLPHSSLFQTLEMAGLASETIKEIKLLYAKCETTIRLPSGPSESILIESGVKQGCPLSPILFNIAMEPLIRAIENGKAGYTINKVQHSSKTFADDLCSIARGVLYAQRQMNFATSVANWLGIKFNANKCSTLHIRSNKVIKTQFKIQGENMEMMDKETSYNYLGVPTGFKIFPSASETIEQLKREVKAIDKSLLAPWQKFDAINTFITTKLSFHLKCGTVPKKPLNELDALIKKVSKKWLNLPVSATCDLLYLPYNAGGMNIIPTSILADISTVSHAFRLLTSNDRTTQKLALDTMKEVVEKRLKKEPTLDEIAEFYNGASSQNIPLINTDVASCWTKLRGAMRRLSSKMKIVFQPDPDKKKFNLIINKAAATRFAVEAQLRDATRNHFKQSLLSKQSQGRVYNVTAKMPVSNHFYRNGNFTRFTEWNFIHRARLNLVPLNGGTKKWVTKDQSCRKCKYPCETLQHVLNNCKQNLPTMTKRHNAVVDRLMDGFKERKKKSQEILLDEIIPITASTLRPDISIIDKQNKEVILVDVTIPFENLPEAFVKARERKIEKYDSIKKELENQGYNVFLDAFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2H3</accession>
    <name>A0A914Z2H3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2H3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6554.t1">
        <property type="protein sequence ID" value="PSU_v2.g6554.t1"/>
        <property type="gene ID" value="PSU_v2.g6554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37446:SF1">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37446">
        <property type="entry name" value="CLAUDIN-LIKE IN CAENORHABDITIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6554.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20534" checksum="CC97530876F3B0C1" modified="2023-02-22" version="1">MCLSQVGKLLYLSLMFVIFCLTVAGTFTPHWRDLYLDGETDSIGHIGLKGGCDMSGDNAAPYDQYCTYWNDNKPKYENTVKAFLYAAMAIEVLAMGWVILSCLAFCYHSRFMHALTGWSALILMCLAVAVIAYLANREKTIQTNGVISYMTVKIGYSFDLIAAATACSIASIVLGGITSWLSDQPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2L1</accession>
    <name>A0A914Z2L1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2L1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6128.t1">
        <property type="protein sequence ID" value="PSU_v2.g6128.t1"/>
        <property type="gene ID" value="PSU_v2.g6128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6128.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="20876" checksum="B25C8446C561B7F5" modified="2023-02-22" version="1">MTGRPFMTSLPSPTSPFISSTTTTSLFVASTTFSMFDDQERVPNKYIHRYHPMNATSCPSRSSTSTLSLEDQKELDRLTAIVDKYIPTTPLHTPLTSLQWKILSSASTSTPTTSTPTTSTPITAAATTSTQTAAAPITSTSITDALNAANPTTAMYKENVPLAALQTKRGSWTSKFQATAKRQKQKIQKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2Y2</accession>
    <name>A0A914Z2Y2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CNPPD1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNPPD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2Y2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6249.t1">
        <property type="protein sequence ID" value="PSU_v2.g6249.t1"/>
        <property type="gene ID" value="PSU_v2.g6249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6249.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28249" checksum="92A18D3AA778654B" modified="2023-02-22" version="1">MVYVDRLRRANPEYFVETSPDDIYLSALVIAGKFLQDGGLDEFIWNDEWAQCSSKSVKRVNELELEILFKIDWNLHVSETEFKEAVESAEQWIALHSLKRHKFLTYNDIAVLSKKWDASWKQVKMFFTFTSAISATYLGTFYLALLCSGIYQSEISADSSSILPQTTNETMPSPPSSFNATFDDFTTMNESPTNFAVNDSCSNDSQIQKSIIPNFQNLLQRRPLVVYNNNNFEEENDRWKGIECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3S1</accession>
    <name>A0A914Z3S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3S1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7003.t1">
        <property type="protein sequence ID" value="PSU_v2.g7003.t1"/>
        <property type="gene ID" value="PSU_v2.g7003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037318543" evidence="1">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7003.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="23765" checksum="FAD87C7362CCB65C" modified="2023-02-22" version="1">MLKFLAILAFINVLLSEASVICPTGSVPSLNDNSLCYSFLSSSTEFLNAEQLCADLGGHLASIDSAFTDTFLNQKAETSFKNSNSSDFWVGANDLASSGVWTWTDGKPFAFTDWAQGEPANDAGSDCVSVQLANGLWKAQNCYQRKPFICAIPGTDAKTCPLYCPSEWAFFNQTSSCYKVFFDAKWNDAEAVCVSQGSHLTSVHSDAENVFVASNNSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3Y7</accession>
    <name>A0A914Z3Y7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3Y7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6604.t1">
        <property type="protein sequence ID" value="PSU_v2.g6604.t1"/>
        <property type="gene ID" value="PSU_v2.g6604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6604.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8199" checksum="52E2A0F9DA048A03" modified="2023-02-22" version="1">MFDSAFQEAKENKVTITDSSLEIVKAAMDYCYRQNLSPSFFQDLNNAINLLYFCDKYDFETLKPQCRDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4U7</accession>
    <name>A0A914Z4U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4U7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7380.t1">
        <property type="protein sequence ID" value="PSU_v2.g7380.t1"/>
        <property type="gene ID" value="PSU_v2.g7380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF52">
        <property type="entry name" value="PAIRED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7380.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13196" checksum="8332CDE0AC837630" modified="2023-02-22" version="1">MADREKIVGLYQNGWKICDISKKLCVTHSCVSKILNRFRTTGSVRPKDAKESRVESPLVAAIRDYRFRLGMTRQSEIREQLILDGICQRDNVPSRSSINHILRTKLDVKRPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4Z5</accession>
    <name>A0A914Z4Z5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N6-adenine methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4Z5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7758.t1">
        <property type="protein sequence ID" value="PSU_v2.g7758.t1"/>
        <property type="gene ID" value="PSU_v2.g7758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7758.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="23501" checksum="839618AFE62B4CC4" modified="2023-02-22" version="1">MELCHPSASSPKNVRSMFCRGFGERHDLEQYFWTESTVKRLMNSLNDFYEECCCLTTPSLAHGWHLEGREEWLLDIDRRFEYLPKFRYFNLITPENIEEDFQIIIFDPPFFYISMEQMYKAVCKIVKDNFKTKILIGFLKREERELMRYFGIFGIKPTNFLLEYAQVKPNKWKNYCLYSNVDLPGIKRAKKCNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5W4</accession>
    <name>A0A914Z5W4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z5W4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7336.t1">
        <property type="protein sequence ID" value="PSU_v2.g7336.t1"/>
        <property type="gene ID" value="PSU_v2.g7336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF69">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7336.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30422" checksum="F68B9658347EABEA" modified="2023-02-22" version="1">MPGLHKVLEGILRFRSTVRADLVKQFEKVRDHPDPKAVFFTCMDSRMLPARFTQSQVGDMFVVRNSGNMIPHAKNYGISGYEVSVTTEPAALELAVKRGKINHVIVCGHSDCKAINTLFNLHQCQTKFDPESPMDHWLRRHGYMSIQKLEQRLKSESSVKLKFESENPNLISLTAIIDPDEKFNVEDKLSQINTLQQLTHVASHGFLQEFIETGRVFLHAMWFDIYTGNMYMFSKKQERFLIIDEETATPLENEVDEEMKEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5Y9</accession>
    <name>A0A914Z5Y9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5Y9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7364.t1">
        <property type="protein sequence ID" value="PSU_v2.g7364.t1"/>
        <property type="gene ID" value="PSU_v2.g7364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7364.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15645" checksum="131B4E7AC13130D0" modified="2023-02-22" version="1">MRDRSETEEALLRCAALCNRAEFKPGQEELSILKRECSGDASEIALLKFAELTVGKIMEYRLKNTKIAEIPFNSTNKYQISIHKTADGHDSLLLVMKGAPEKILDACSTMLLDGKEVKLDDQHRADFNAAYLDLGGRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z622</accession>
    <name>A0A914Z622_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z622"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7362.t1">
        <property type="protein sequence ID" value="PSU_v2.g7362.t1"/>
        <property type="gene ID" value="PSU_v2.g7362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7362.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33594" checksum="73A47B8EDF539842" modified="2023-02-22" version="1">MSKPSSMNFGHQNYNHFMRGQPQQQFQRNFNTSPSTSSLDSPTMMLTNSSQSFTLSTDESTTKEETARDIFFRTLSASLKEANKFYSGKTTTWKNPFLYKTNLCDNYSNRLYCRYGVNCWYAHGPHELRCIPETEELPDPIFISQYLSFLGLPKQTLEQIIQYAYTVANLFSSTDNPQWFTSSKKSAATNDLPSFDSISSLSGPLSPNKKNIEKINNDKSDLPLIDSTKPINIIPKQPNNEKFLSSLTSNGGWGEIESALNDIVDENSGINENFDDKFCANSYRLFGDSCNSQKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z633</accession>
    <name>A0A914Z633_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z633"/>
    <dbReference type="WBParaSite" id="PSU_v2.g814.t1">
        <property type="protein sequence ID" value="PSU_v2.g814.t1"/>
        <property type="gene ID" value="PSU_v2.g814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1550">
        <property type="entry name" value="ROS/MUCR transcriptional regulator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041920">
        <property type="entry name" value="ROS/MUCR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008807">
        <property type="entry name" value="ROS_MUCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05443">
        <property type="entry name" value="ROS_MUCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g814.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7820" checksum="BD0BA7CA561277A8" modified="2023-02-22" version="1">MTCLECGSQFKSLKRHLMSNHNLTPEEYRARWELPASYPMVAPAYAEKRSALAKTIGLGRKPGQSPKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z678</accession>
    <name>A0A914Z678_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z678"/>
    <dbReference type="WBParaSite" id="PSU_v2.g819.t1">
        <property type="protein sequence ID" value="PSU_v2.g819.t1"/>
        <property type="gene ID" value="PSU_v2.g819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000339">
        <property type="entry name" value="Protein CBG02163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g819.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10479" checksum="B526C2B8FD14A85C" modified="2023-02-22" version="1">MKCDVDIRKDLYGNIVMSGGTTMFNGIDDRMAKEVTALAPASMQIKVIAPPERKFSVWIGGSILAYLSTFQQMWVTREEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7F9</accession>
    <name>A0A914Z7F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7F9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7813.t1">
        <property type="protein sequence ID" value="PSU_v2.g7813.t1"/>
        <property type="gene ID" value="PSU_v2.g7813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7813.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16959" checksum="8B6596A7CC9BEE08" modified="2023-02-22" version="1">MRNATAAIIVYDITCRKSFEEVDKWVSELYRCSGIRDPIIFLIGNKLDIECSRQITEGEGITKAAKLNAHFFEVSAYKTATIDSVFATLAEAIHDRMKEDSITTSEPYSPSSTSTSSRESPIFRLLTSPLTRSRSASGELLSHPKKDSGCCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2024-10-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7G1</accession>
    <name>A0A914Z7G1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g8622.t1">
        <property type="protein sequence ID" value="PSU_v2.g8622.t1"/>
        <property type="gene ID" value="PSU_v2.g8622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF226">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="1">
        <location>
            <begin position="100"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8622.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="32358" checksum="6A12756D14CCFB39" modified="2023-02-22" version="1">MLSRLVSSRSYSAAATAASRSSSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSRLSNGITVGSIDNQGPVSQYVIAYRAGTRYEQADEAGLVHHLRHAIGIDSNNYLGVKLLWQNGSIGGTLTASSDRDLLLIHISALRNHSPIALSLLGEFAQPAMKPWDLEDVSHSMKIAAKAVDPFDATIEHLHRSAYRNGPLANSNITPDFRAGKFCPKKLAKFARSRLVAGEAAVVGINVDHSLLVQFANEQNSIPEGKGPAAPASPYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7Q3</accession>
    <name>A0A914Z7Q3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7Q3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8354.t1">
        <property type="protein sequence ID" value="PSU_v2.g8354.t1"/>
        <property type="gene ID" value="PSU_v2.g8354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053302">
        <property type="entry name" value="CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058960">
        <property type="entry name" value="Ctg-1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159:SF6">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159">
        <property type="entry name" value="PROTEIN CBG07705-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25883">
        <property type="entry name" value="F28H7_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="90"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8354.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="52211" checksum="B6E07DF4B2F8D049" modified="2023-02-22" version="1">MTKDASTQHGEALSQESKKLVNEVRLRLTQPIHPNFNTDFNIYRFVLNAERQFGKSKDIIEAAAKGVNNHLRLRKCLHLDEMEDVPFSKNPIFTNRFLPQGEIRQETDNQGRALWFVEYATITVEGIAHSIRSSAAIRYQFWQFEHMLRRVMKQEEVTGKLSSLRHIIDLTGYEINPFMMIFVSSGTLSYYSNLLHYENYPELVYPVEIVNVTKWVHMPYRLVKTMMPAGFTDRFRLYDNQFLETLGKEMSVESIPETLGGKNKEIKCIPAVHIPPEEYWKPPSELILTLLEPFHVSAKKQKFYKIEIPEGQQRKTLSWYFQNDGDIFFGIFYDSALHSSALTNGKKAAVKEEKDLDTDSKEMVTPFVKITAKFVHEFDYLDLEKPGIYYILFCNRHSWLHRRNVDSLIQISNADGSEPKRCFFDGTQSSMADEESIIKILNLREFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z840</accession>
    <name>A0A914Z840_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z840"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6418.t1">
        <property type="protein sequence ID" value="PSU_v2.g6418.t1"/>
        <property type="gene ID" value="PSU_v2.g6418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="231"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6418.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33912" checksum="8A205254F31FC0FF" modified="2023-02-22" version="1">MVVAQTCGSPALRVVQLDAYVLDKEIEAYLETQLKELVSYLPISVTIVFQRYIAEVRVILSGVLWFYRIFRGFSPGQEMMEIAYRYYPKKVAISHFLAVIILPYILEKISDKIEDPEKKAFIQKIIHFGRLLEFLHHFYFLNKGGFSTIWERILGLKAEYITPPTLGLINYTSLNRELLWHSYRDLLLLALPLGQTARQLWTRWRTRRALKTSAAKKFLKQNMKPFSPILCSRCDKSAVIPVQNQNANISEQCGHIFCLYCYDSRIECPKCGLFLVKGKEIRLRGFTYHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8A0</accession>
    <name>A0A914Z8A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTHB1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8A0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8123.t1">
        <property type="protein sequence ID" value="PSU_v2.g8123.t1"/>
        <property type="gene ID" value="PSU_v2.g8123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055363">
        <property type="entry name" value="PTHB1_hp_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23338">
        <property type="entry name" value="PTHB1_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 hairpin" evidence="3">
        <location>
            <begin position="479"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8123.t1"/>
        </source>
    </evidence>
    <sequence length="660" mass="74583" checksum="49BD4BC62B235E5D" modified="2023-02-22" version="1">MSLFHYQEWFDAFFPDCRGITTGVFFDDRSQIIVGTLNGLLGALDPGKDVENRQETASLIEQQLSNPIIQVEVGNFLTNFSGPVIAVLHPKELHFYSLVRDANDMYRFDKIFQHRIKGQPAYNMCIGNYGKSEKPRICVQTINCTLHFFESENHILTRESFHQIHPGPIAYHPVTDSVITTSGGVINAVKFTTMASMPSNKKDYKTMMEWDLNIGDTAVAVEAIVPSEENPVQPSLAVLCRRSLHCLTSSGSIRYTLRLENPAMAMYIQIRNATIHYIFATHVKTLLFYQDTTMIWAAQLNFIPISVTLATFGDGYKAMITLLSDEYRVSVGYLGTEPSFFRMPVTDSRFIDFEARQKELAGYEEEIATNTKNSSSTDPENDEIKVSFEVHMDTQSNAIDTDEPVPSATLKVIAIGSYSVLDIFIDNLLSIVQIGHGPTRDETDPTKNIYMYTMFAEKPIYDHRMSIIALADSRDTAEKRFEIEETNVRRLTVQMRHVEMVLLQKLKSENETPPSHVNILVNYTYRDLLMAFDRMQALEEKVVFSGKRSLRSQLNLFTLLLEMVEIELPFDGRVLDGTFQKLGDRISFLLPSSILTGSTTPEPAEICRMIVNYCERGGKLTEVAIAEEDEEEEGEGEAEGNASEEFLNLKSGTVPVRLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z936</accession>
    <name>A0A914Z936_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z936"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8840.t1">
        <property type="protein sequence ID" value="PSU_v2.g8840.t1"/>
        <property type="gene ID" value="PSU_v2.g8840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8840.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25759" checksum="056226B7DCB512F3" modified="2023-02-22" version="1">MNAVLIKCKKGKEYRVPLEIVVLSDKPQRVHASASYISTHLSERLKELAALVPGKRWEYICDAAGKFHAALMDTPGKSNLLKEIGLELNDIPITVNARVLDPPVDTYSKDDETLAIPYQNPVEYVLVDFSKNNNDENDNVEENVNHLMERMREKFGISITNTQVFFKFKYNANANCGDENVLKDLETVVQWHTENKPKKAGRKLIYIVVIENAHKSTNLHGTEYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9Y5</accession>
    <name>A0A914Z9Y5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9Y5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7055.t1">
        <property type="protein sequence ID" value="PSU_v2.g7055.t1"/>
        <property type="gene ID" value="PSU_v2.g7055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7055.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9252" checksum="766C924955D1ECF2" modified="2023-02-22" version="1">MPMDSLRPTLVKPTKHAVEKYYEALNDLHAAVKEFDESSAAFDDAFPQKEPESSVPKENDENSPPPISQKKPSDETKAPRNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA56</accession>
    <name>A0A914ZA56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA56"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8806.t1">
        <property type="protein sequence ID" value="PSU_v2.g8806.t1"/>
        <property type="gene ID" value="PSU_v2.g8806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8806.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="20622" checksum="D793FF40ADFCA212" modified="2023-02-22" version="1">MDQYEKEKKHLFQYLRQTLLTGVFYNVFTFFPNFFDYFRLRKLLNIQEFTEEETNTLNECMNNLIEVISENLGHYLTRYYIKDLYKVLKIRSVLEFFKTDFIKFINENSKEKLKKITAYNSDIGEIPNFDGIPESHYWWTQHHRNGDANPPEFDFEEYSRIVCPDYKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAE8</accession>
    <name>A0A914ZAE8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZAE8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8896.t1">
        <property type="protein sequence ID" value="PSU_v2.g8896.t1"/>
        <property type="gene ID" value="PSU_v2.g8896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8896.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27023" checksum="586A869BA27DEBD7" modified="2023-02-22" version="1">MLQAVVICSEKKYQIIKQSDANEFLTFLLNNLHVALNGTNKTPSSIIYKTFRGRMRVFTRKVLPVDASDEARRTLLETEEFREKVEELPFLKLTMELPPPPLYRDELLQNVIPQVPLGTLLSKFNGSTEKEFKTYNANFIKRFELIRLPEYLIVAYSRFEKNRFFVEKNPTIVNFPISNVDLFDCLAEDARSLHKFTTYDLICNVVHDGQPEGGSSRVQVIHNENGLNWKICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAL9</accession>
    <name>A0A914ZAL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysozyme</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAL9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9367.t1">
        <property type="protein sequence ID" value="PSU_v2.g9367.t1"/>
        <property type="gene ID" value="PSU_v2.g9367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051595">
        <property type="entry name" value="GH25_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208">
        <property type="entry name" value="LYSOZYME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208:SF36">
        <property type="entry name" value="LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037804528" evidence="1">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9367.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20712" checksum="A46753FCDB115AF9" modified="2023-02-22" version="1">MKLLTFTCFIAFWSLSEGSLGWDGIQAVDVAGFKCLAENGFSFYIARVWRSIGSADPTGIQNIKNARKAGWKYVDGYIFPCFKKSCGSAKYQMDIEIQEWPADKSANQAFITDMVQQAEAMGTIIVGTDWKEVADKPLWYAHWDEQQNFDGFKAFGGWTKPAIHQFEGDVKGPCGVSMDKNWYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDH3</accession>
    <name>A0A914ZDH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9989.t1">
        <property type="protein sequence ID" value="PSU_v2.g9989.t1"/>
        <property type="gene ID" value="PSU_v2.g9989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF5">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9989.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22484" checksum="EE4000C052AACD0A" modified="2023-02-22" version="1">MMRPNLANKNPRLPGASLQKPKSVRKVPSHLDNHKRHPNEFEYLLSKNAKDHEFYRKSSAETTLMTLKRHWRKLSHFLVEDWFLSALLGVIVAVISIFVDISYEYLNYFQVVLYDYALNYDRLLAFVCWTSYITVFVAAATLVCKYVGKQAIGSGIPQLKVIMNGFVLQNYLSMRTLVAKVLGLILTLGSGKCHGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGW2</accession>
    <name>A0A914ZGW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZGW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9528.t1">
        <property type="protein sequence ID" value="PSU_v2.g9528.t1"/>
        <property type="gene ID" value="PSU_v2.g9528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9528.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28321" checksum="44697C9E6AAE8823" modified="2023-02-22" version="1">MSNKSYLAAANKFISIDHEIFEYPYPLSTCDIAYYGCFCALASYDRNELNEKVITNGNVRKFLEPEGKLVDLIQAFRNNSFATVFQLLEEMRPLLLLNIFIEPQQKQLYQLIRHRAFVQYISTFGVISIPTMAIVFSIDTNELIDELVNLIDCGIIDARIDPISKTLYRLDENATLKNSTRLAKIQKDLEQQAHILVLRAAVLINGVNPAKEFEAEMEASGAGGMRHRMGTFDDSDMMDYFVYDEPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQM3</accession>
    <name>A0A914XQM3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XQM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10304.t1">
        <property type="protein sequence ID" value="PSU_v2.g10304.t1"/>
        <property type="gene ID" value="PSU_v2.g10304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10304.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36287" checksum="524CAF803C1265CB" modified="2023-02-22" version="1">MNSLHPDALTLYECVRRGARISKNGPMLGKRVKQADGTEPYVWLNYDEIIDRSVTLAHALRHIGIPSGQSAFIGIYAKNRPEWIITEYATYTFSNILVPLYETLGAEACVFSLNQTEIQIVFCDTFAKAKSLKEKKDQCSFLKFLVVMDEGITEKDKAAFTEVGLTLYGFSELEALGATAEKTPIVEPKPDDLATICYTSGTTGTPKGVMLTHGNITADATTLAYFKYIELTSADVMMSFLPLAHMFERVVQSVMYTQGGRVGFFRGDIRGLADDIKTLQPTILPVVPRVLNRIYDKVMSEVNKSLFRKTLFNAALSYKLREINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT06</accession>
    <name>A0A914XT06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT06"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10406.t1">
        <property type="protein sequence ID" value="PSU_v2.g10406.t1"/>
        <property type="gene ID" value="PSU_v2.g10406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10406.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8080" checksum="4DF3DDB3FE5BDDDB" modified="2023-02-22" version="1">MRGIGTNVAMYLPIFPRLLSLSNAYWEGVIEEGVKFFANTPVSRSSSKKMKVDLSRSITVAKLQQTGSIRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX45</accession>
    <name>A0A914XX45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12520.t1">
        <property type="protein sequence ID" value="PSU_v2.g12520.t1"/>
        <property type="gene ID" value="PSU_v2.g12520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34859:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34859">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12520.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="12846" checksum="0C2DCCF73C397108" modified="2023-02-22" version="1">MLYKSLIDTGLSCTKKTYGRGVGIPLGCVKGMVEDAALCYPGCQGNYNGVGPVCWDTCPKGKFGCGALCLNSEDECVKEMLSIAQEVALAVAEIASDPADAIVVLGKTVAKLAPELAKPICTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX54</accession>
    <name>A0A914XX54_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XX54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1253.t1">
        <property type="protein sequence ID" value="PSU_v2.g1253.t1"/>
        <property type="gene ID" value="PSU_v2.g1253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="64"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1253.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34239" checksum="E536B8ED1A689159" modified="2023-02-22" version="1">MSVYSGTSDMSDSSNATIETTASAPAISEIIREQPKPSVDKIMPTIGGTDIVKPTSNQLSITDFTFVKVLGKGSFGKVLLAEKNGTDEVFAVKVLKKHVILQDDDVECTMCEKRILALAAKHPFLTALYSSFQSPDRLFFCMEYVNGGDLMFQIQRARKFEEPRARFYAAEVTCALQFLHRHEVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPFEADNEDDLFEAILHDDVLYPVWLSKEAVSILKSVRIFTINNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXA4</accession>
    <name>A0A914XXA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1184.t1">
        <property type="protein sequence ID" value="PSU_v2.g1184.t1"/>
        <property type="gene ID" value="PSU_v2.g1184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037892987" evidence="2">
        <location>
            <begin position="20"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="3">
        <location>
            <begin position="35"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1184.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37078" checksum="170F4ACA87CA7A2B" modified="2023-02-22" version="1">MASAIAAFNILQLLTLPSAQEVNSDFSQFNNNYNRLINKLFDVRKYERWKPSHTPIDVGAFVIIDHVENMDEYAQTLTFHGTLVMTWKDKRLVWEPQDYGNLNQTYISLNIASIWTPPVYFRTLVRATSKVLQYHNTEISLDSSGSITAITGISVMTECKMDYTNYPFDNQTCSILFVSPMMNSQRMVFTESPVFVKRDSLYGAQENNMTSGAYFEVTGLKSQRYYYSPKGLTSNETIYRAYSPERTSTILRFELSLKRNPNYYMALIALPLLASSLSAYVVACMSHSAVSLVWLSVCLVMQALNIVRMVEDLPPDYNKTPFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY54</accession>
    <name>A0A914XY54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11465.t1">
        <property type="protein sequence ID" value="PSU_v2.g11465.t1"/>
        <property type="gene ID" value="PSU_v2.g11465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11465.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8649" checksum="B468FBC6B38B928A" modified="2023-02-22" version="1">MPGNGVTLIGGRRFLPPHLFSSTTSTPVPKDGRLPAFLDGWEVFTFFIIMLIVVPPIVICFKRRCINNQRSGYENVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYK3</accession>
    <name>A0A914XYK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MnmE helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10773.t1">
        <property type="protein sequence ID" value="PSU_v2.g10773.t1"/>
        <property type="gene ID" value="PSU_v2.g10773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MnmE helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10773.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16954" checksum="46D5116A1416A4EA" modified="2023-02-22" version="1">MDEILGFQNENDGRKMIICLNKADLLDQSKKDELNQKMLHYFQNKSISFIWTSCFEENGLSTLLSSLKNSINNLCDVENDECVLSRQRHILLLQESIIEMNSFLENLSFDQALAAQNLQNAANCIGEISGTIVNEQILDKIFSQFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYZ3</accession>
    <name>A0A914XYZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Decapping nuclease</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10903.t1">
        <property type="protein sequence ID" value="PSU_v2.g10903.t1"/>
        <property type="gene ID" value="PSU_v2.g10903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10903.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15865" checksum="F16796324FF770A9" modified="2023-02-22" version="1">MNYVVSKGFIPRSTAVNYCGVCVEVKSQEKIIFGSFKDIYGVYNLLQPNGHQSPVRTDRRQRFTKLKLTINKLLPMVKKMKGVEWYLCVEKDGILTVKHNSMIYPTDYLIAEMKQPRDATSEFNLIKSSLITAKHCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ76</accession>
    <name>A0A914XZ76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ76"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11836.t1">
        <property type="protein sequence ID" value="PSU_v2.g11836.t1"/>
        <property type="gene ID" value="PSU_v2.g11836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11836.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8494" checksum="99AFE0C097B74692" modified="2023-02-22" version="1">MAERSKTELGAKIDRCFADSLLKAAGGLAIGIGQGWSNCRDDLQNPYLLHGKKIRVGSEMGKPAYMIQVVDPALKKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0X8</accession>
    <name>A0A914Y0X8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y0X8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11499.t1">
        <property type="protein sequence ID" value="PSU_v2.g11499.t1"/>
        <property type="gene ID" value="PSU_v2.g11499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF27">
        <property type="entry name" value="FIBRILLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="624"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11499.t1"/>
        </source>
    </evidence>
    <sequence length="710" mass="78903" checksum="7618ED10E42F04DB" modified="2023-02-22" version="1">MDGFQGALCQYDINECLSLNGGCHHQCINIVGGFYCRCHPGFELSDDSRTCIDTDECKIENGACQYRCVNTEGGHRCECPPNKQLAPDGRTCIDENSCQPPLNGGCSHLCEEKDGKFFRCRCRTGFKLADDKRNCYPIDPCHENRGGCSHACLNDNGRAVCQCFPGYTLDFDQKNCIDLNECQSSDANHCQHECVNTFGSFRCRCFAGFKLADDQRTCIPKTEGCSINNGECEHDCFEQPDGGIRCGCKDGYRLAEDGKTCTEFDWMEYRQWRAAEESFTVMPRSEKINNNNYNKIIIQCLTDQGQCHELCLNELTGETFCQCRKGFELHIVNRHFCQDIDECVNDQAGCSHGCKNIKGGFECTCDSGFTLSEDRQTCIDQNECLSNNGNCSQLCKNEVGSHRCECFTGYVIDADGRTCIAGPEGLLPDSAKNILINEKHIKQFDHVDADEMSSERLYEYSYHTPGSKPAAEGVRIHMPLSLLPPNFQECERGEFGLNCQFTCANCQHGSTCDHQKTSCECLPGWQGEICEMPCQKGTYGIGCNKICDCGGAECNHITGECLCPKGAECDQDPCPPGFYGKDCELTCRMTECPGGLCDRTFGYCICPPGYYDEKCDKSCPPFTYGSNCRFTSKCSKEGTEMVDPKSGTCECKPGYYKTHCNKRCPLGTYGPGCINKCNCESRNSQCDPGTGECRRSCLPGFMGDDCKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y269</accession>
    <name>A0A914Y269_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y269"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1333.t1">
        <property type="protein sequence ID" value="PSU_v2.g1333.t1"/>
        <property type="gene ID" value="PSU_v2.g1333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF309">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="44"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1333.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25179" checksum="8C85E7F21B94B390" modified="2023-02-22" version="1">MVTSDIGRFFCGFIFDALHKSPWRSMIALTVLLACYPFLMGLLVSYISHLSLVDSIYYSVMCIFTIGYGDILYAFSFSFSDIMIFDFLRPPIPVPVLILLIVFGVTLVTVSVELVGSTIIHNVHYMGRQMDRAREIAGKVIKMAQKLNVNRGLSMGISQLNAFTRLGMSMNMVQTIAVDSPNDVIIRKEAAFEPSIALDFVDFVSSESEVFIEEIFEKKGKIEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2G5</accession>
    <name>A0A914Y2G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2G5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13429.t1">
        <property type="protein sequence ID" value="PSU_v2.g13429.t1"/>
        <property type="gene ID" value="PSU_v2.g13429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056852">
        <property type="entry name" value="AK17A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484">
        <property type="entry name" value="B-LYMPHOCYTE ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25015">
        <property type="entry name" value="RBD_AKAP-17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13429.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38712" checksum="995B0859411A519D" modified="2023-02-22" version="1">MDEDKDIPMLDCGEEAITFFEERGVHIIPIYALTFIVDLPMRPPGQTFSNWDIREKIKTFAHPHELKDLKIIESSDEHIKFTTHVVNIDIMDEIITLLDNITFRAPGFESALKVAVRVGGYPFPKPEDWKKHFRGQKLKQDEPGERPDTVHIAGLPYEWFAPNISDDVTSIMLDIMNQYGKVRQIDIPQEDPYRNEMEPNISGMKLHWFDGSFSPFFEMYVQYEDYEGFYNAMTKMGGHQLVRRAASGILSEYQYTIDFDRNAHLSNRIIIQRELARQCIIYRKKHEAEEREKKIIEEIKRKTMGQLEKGVIEAKVRVCLEQQEVYFLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2H1</accession>
    <name>A0A914Y2H1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2H1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11990.t1">
        <property type="protein sequence ID" value="PSU_v2.g11990.t1"/>
        <property type="gene ID" value="PSU_v2.g11990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF8">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="393"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11990.t1"/>
        </source>
    </evidence>
    <sequence length="663" mass="75342" checksum="1754C54FCB1CC745" modified="2023-02-22" version="1">MQRCIISPEAESFEAHIFCDASQYGISAAVYLRQTLKTGEYLVNLLLAKARVTAIEKTTIPKLELAAVSIGASLIPFIKKELPIELTRIILWTDSSCTVGWLASTAKFGRYIDNRLSHIRERATIVKHVRTDENPADLGSRGCHFPELAANKKWWHGPGFLQLPEEKWPLEAVKAVEINHNPYIDSIMEENVEQHTVSVTTAAQESKLLVPKIEIDATRFSKWIKLIMSVSSILFFIQKIYKNASSSFLKSFMKIKYESRNSPGMITVAENFVIRQLQQKYPPTANLKRSLMLTVDENDILVCNHRIPSERGLGLIWLPDCLELNLLIIHIHEKLFHSGPRETLNELRSRFWICQGKRTVMKAINKQCQHCKLLKLKPYQMPAMPALPTERIQAFAPFLHTGLDYAGPFMIKQGAENVKCWLILFTCLSTRAIHLETVTGLDSYNFILAFDRFVARRGRPNLVISDNQTTLKAASKLLVPCWQNKENDLLEYIAKEQFTWKFITEKAPWMGGFYERLIGLTKSALSHAIGKRILTFQEFQTVAVRCEAVVNLRPLTPVDAEYKPNDPSQIALRPVDFLLPHAPAVGHVVMIEEENIINNTWKLGIIQELMPSKDNEIRSAKVKTPNGHILTRALCQLYPLELSLADPTSIKQQQADLNKDNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2P5</accession>
    <name>A0A914Y2P5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2P5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12052.t1">
        <property type="protein sequence ID" value="PSU_v2.g12052.t1"/>
        <property type="gene ID" value="PSU_v2.g12052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="61"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12052.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="39999" checksum="0E5B1A436575A9EB" modified="2023-02-22" version="1">MIDNNPYVAAADIRVSNQMNNVPAQVLKAPLIVFKENGKSVNFAEWNLHDVSFVQPARINAFIVFLSSNGINYVLALAAGTPFHHILKATEVVSGVVTQQIEPKTATSQKLGQVTIGNIILKMNPKLGGYNQYFQQGAPSALNNQNVDAFKSFMEVTMVMGFYLSHSAPGNSREGEPSVCGYSFSINNRGNVARGGFIYFQGRDFEAGNADEQAPMKHTLTDIELRKPLQEACTLYFEKNGKYPEYVLVYRFGTSDGEIEKVKSEESGYMASILSDAMDGRSPKLIVISVRRQHNTRLFKQHADINGNDKAPLQNVEPGSCVAGTNPADIVMVPHRALQVRNCKPHFCSNLPSSEDLDVSQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3T9</accession>
    <name>A0A914Y3T9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3T9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14102.t1">
        <property type="protein sequence ID" value="PSU_v2.g14102.t1"/>
        <property type="gene ID" value="PSU_v2.g14102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14102.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9691" checksum="FB035687AF20EF47" modified="2023-02-22" version="1">MAFYGANSVSSAPFASAPLNTTDFDASRNLFMANADPDYFINPLDDGDACNNNQTNNISLACNAAMNQSCVWQGFVEGCSVAAPSEYEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-06-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y451</accession>
    <name>A0A914Y451_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g14008.t1">
        <property type="protein sequence ID" value="PSU_v2.g14008.t1"/>
        <property type="gene ID" value="PSU_v2.g14008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14008.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22077" checksum="A838A85E0A556C13" modified="2023-02-22" version="1">MVTKFNFKNLFKFVPKASVFEYAFSSNPSNFSSETINELIEMPHFLNMSTFGLYRIHDSFDVRPLIEFWKMKRGDFRIHFSESISDDYWNQIYKIVFEIIATGNFIYGPPRLTLPGLSEQYQKALYDKSKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4U5</accession>
    <name>A0A914Y4U5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4U5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12733.t1">
        <property type="protein sequence ID" value="PSU_v2.g12733.t1"/>
        <property type="gene ID" value="PSU_v2.g12733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12733.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21609" checksum="991A69A92223776D" modified="2023-02-22" version="1">MNCPDVNDVACIMRHDSFNKTANFMCVKTNCTLNGMVIQDSICINTTTSLTNCCCHGDGCNSAYLLSLQKSSIVLPPTIPSNSSNPSNPSNPSNPTINKPLSLPVTTMSKDQVIGCDKDGFKVLSTIADSAVLTQGKFAGYLINPLSCQELCKQSFGLFKCVSYMYESKNRGKCSLFQQPINEKIIENSNSGAFVSTKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5P4</accession>
    <name>A0A914Y5P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5P4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1552.t1">
        <property type="protein sequence ID" value="PSU_v2.g1552.t1"/>
        <property type="gene ID" value="PSU_v2.g1552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1552.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8163" checksum="680317709C194563" modified="2023-02-22" version="1">MTAASQNSGDPFYVVTYYKQTCNSDANLNKAMEVLTDKTAQTRLRGVVTNIVNTMPTQIQSIALALIDQSFSGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6E3</accession>
    <name>A0A914Y6E3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-Fucosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6E3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15018.t1">
        <property type="protein sequence ID" value="PSU_v2.g15018.t1"/>
        <property type="gene ID" value="PSU_v2.g15018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052501">
        <property type="entry name" value="Alpha-1-2_FucT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22898:SF3">
        <property type="entry name" value="ALPHA-1,2-FUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22898">
        <property type="entry name" value="UNCHARACTERIZED GLYCOSOL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15018.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27668" checksum="03F54C90B7B6D5BE" modified="2023-02-22" version="1">MHDFPQKYLILNGNFLQSFKYFNDRKAEIRHFFEFDEIIKKSVEEKGKNIFGNDIFHKLCIHIRRGDFIKHEQLESREEFVEPAIRFLHQNFTQKGLSNISLIFLGTDHAFIKNLKFNQSLFNSVYHPILKSRGEDMYFGIRYCNTLLITASGSTFAWWIGYLMPEGSQIFYNTQIGKNRTYPKDYYDFDIFPSDWNMLELNRSSKVVELDNRWHYERFAWPRKGIPPLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6H1</accession>
    <name>A0A914Y6H1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import receptor subunit TOM22 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6H1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14357.t1">
        <property type="protein sequence ID" value="PSU_v2.g14357.t1"/>
        <property type="gene ID" value="PSU_v2.g14357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14357.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11543" checksum="4FF9BAE97B44E2ED" modified="2023-02-22" version="1">MAALPAPKDDGILVETYYERLEALKEMFPATLRNVTSKAVSGGWTLFTFTKQAAWIISTTAMIMVLPYIIEKERADNEKAQVQQQRQMLLGPQAAVQGSQPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6V6</accession>
    <name>A0A914Y6V6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6V6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15943.t1">
        <property type="protein sequence ID" value="PSU_v2.g15943.t1"/>
        <property type="gene ID" value="PSU_v2.g15943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15943.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39658" checksum="05235079EDE27CAE" modified="2023-02-22" version="1">MFIQRAQIKIGGFLHCKKLGSKSRKFTGDSNCLPPECLDETVKEVVIDKSIDYWSLGLLTLEIITGKRHYLKEKKSRRLAREYLDGIRPLPTLGETDPKTLKNGVQAYNQYIENFLSRLITLNPKDRMTFSEVLSHPFISGLIDKHEVIRQWKITSDHYSPCDGTRSLYHDMWASQGSTTSVNEELLLNIIQAIRHVEKDDYPLFAKVPESHLYKHYVGIEASVAIPYEDANWSRDVLDISQRNLYEDEDAKEYESQFHIRDDVRDSDDEWEDLADARRRRRQILPDEIHLKSGHPGLDKDYQRFEICFFVKKAWSVKERQIFIAMQFGRWYQRGVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7G6</accession>
    <name>A0A914Y7G6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7G6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16148.t1">
        <property type="protein sequence ID" value="PSU_v2.g16148.t1"/>
        <property type="gene ID" value="PSU_v2.g16148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16148.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18764" checksum="B657A8D70E802EC0" modified="2023-02-22" version="1">MKKNKKYAKAVRGPKAQRNDDDEPQSEAIQNYSNMKLKFKKDMKGIVKQADPARESQTMQMFEMIKNKITKPKEVSSAAEAKVEEALPPEVLEAAARNKAVFEENAEDEVGETWMAKKFNAPEDISGVTKARDANMKDQDDEWYPIGDPRNKMAQRRRDGALDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7X6</accession>
    <name>A0A914Y7X6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7X6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16303.t1">
        <property type="protein sequence ID" value="PSU_v2.g16303.t1"/>
        <property type="gene ID" value="PSU_v2.g16303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16303.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10616" checksum="699C99D6C02374D2" modified="2023-02-22" version="1">MKPQKFGFNSPDLGGGKYLAAGASKLVVCVEGTRNEGAPAVIIDSKKTPFYQSMNLLEMICAALQTGPNITPNRNQWEIAEKYVKRNLSCFFFIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8K3</accession>
    <name>A0A914Y8K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrator complex subunit 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Integrator subunit 7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8K3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13915.t1">
        <property type="protein sequence ID" value="PSU_v2.g13915.t1"/>
        <property type="gene ID" value="PSU_v2.g13915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033060">
        <property type="entry name" value="INTS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056516">
        <property type="entry name" value="INTS7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13322">
        <property type="entry name" value="C1ORF73 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13322:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24436">
        <property type="entry name" value="INTS7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 7 N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13915.t1"/>
        </source>
    </evidence>
    <sequence length="907" mass="103271" checksum="E794D77DEF84122B" modified="2023-02-22" version="1">MESLYYIQQIEKSDPATMSVEKFMAQLDRALTQEPYVLVSTITAASEFLKQHPFPEVLNRIFNTLAKVFGDKTSIPETKVILFRIVQLTRESKKFIREYHTSDVMLRVIMMVSHNLDPEIRALCLMLLEGLASVVCDDSHAQHLIIEGLGAPTLIEKTAAIAAVKEFVEHSKQFCELVIQKFEDLLFSSEITSALKVNLINILPHFRDGVTLCDRIYALGKRLLAENLQKEVTIAAYDLLTHVAAKGIQVGNHADFLMDTIVEYKNEPIILQRLFKNLAKISASTHWEKKQIKRLLNLYPLCQQQKSSPAVIYYFLKALKEFTSESRYIEEIKGIDNYLIALLSHPNFSVCVGAARIVVNLQDYDTSSTTLLNFFPNVIERLSDAKPKEQRVFCKILADYCGNKTTTDEGVKFIACHLICSTTLNSASFETVLETLNSVCAQFPRIYPLAIKFAQTILDKQVEIIQSETDIDMDQGFLSTFKPHPHLFSLLLAPDFARDLTSLPLEDIVRDYGMKVDYPFRYDIAIAAFRYGHWRKVALPLLESLQLGKLQSTFALWIKCLINLAKSQPTSFTVKDLSLSQMQMKSAQLIAENLVNICDKGRFFKFSLAFIEIFNDIIYLLNSYLGMITVNQMILNSESVYAKRGVAAQCKLYSVRSAEALIKLDLLFQRSFDVDNESRAQLFLLRQFLDLIHFSFGFFFLSQPSRMPSPYFVETNSPTNAHLLELISWARSQFSKLYEIEKETWRIRITETNAFFVKDILFMLLSNSFYLPRSFFHFVYSTKIRLNIKSEGKETSDHGRYLVSGAASLHPIMVEGFVETNNPAGIKAVIIHGSIATLAKAGTEQFKPVHQRATELPDDANSFSLHFTFNVHHTSKIRFEVSFIDKATKKTWQSNTVEDIIIQIGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8S8</accession>
    <name>A0A914Y8S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8S8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16596.t1">
        <property type="protein sequence ID" value="PSU_v2.g16596.t1"/>
        <property type="gene ID" value="PSU_v2.g16596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16596.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12332" checksum="1F9A2AAE14D713F5" modified="2023-02-22" version="1">MPLEIQGHLVGIWDVARMFRMNRVHRIPVVHSDSGMFNGEQPNLLYFISLRSIFAEVVIKVMDSKAAITPTFNQLKLKDNKIGTWDNIVQVSVHFLKYKISISKKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9X0</accession>
    <name>A0A914Y9X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9X0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15560.t1">
        <property type="protein sequence ID" value="PSU_v2.g15560.t1"/>
        <property type="gene ID" value="PSU_v2.g15560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15560.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17014" checksum="7CEE69A2175D7B27" modified="2023-02-22" version="1">MIDVPKAKAAKEKVAKKICETINNYVNEKTDGKIRDIIKVEELYSAMNILISSGICIVGKWEQPFNDPVFSTFYSSATSKKTIQMLSKSISPGGCNLTKGNSWKCIGLPYKTRNIWLHILLPNEKDGLSHILENLNYSFIKRCVRRYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAM2</accession>
    <name>A0A914YAM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16331.t1">
        <property type="protein sequence ID" value="PSU_v2.g16331.t1"/>
        <property type="gene ID" value="PSU_v2.g16331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16331.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8681" checksum="7D2B36280CC52960" modified="2023-02-22" version="1">MEKEGTHPYKPLPQNKLLRFYIEEKNHKDFLEQQAVIPDGFEVRSINPEFSKQMMSVLLHYQDGDELQAAYVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCF7</accession>
    <name>A0A914YCF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16982.t1">
        <property type="protein sequence ID" value="PSU_v2.g16982.t1"/>
        <property type="gene ID" value="PSU_v2.g16982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16982.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23725" checksum="E367BA8F17212A32" modified="2023-02-22" version="1">MNAITSSSSSSVAAPTAAPTKAAIKTTTESPPYLLIGLTIGLSIIIICILIILIVCLLKKFKKKPEKNQISKKTKKSKIPEVDSKTKSMITKNLPQKTTSSEPSKSKSLTTITQHQHQQQQQQLQTEENETKEIPSKTKQTIDNILPLNIPKVAPEITPHLVEKELDMKQIRTIAEYFLDIEQQKLRIKNNDEKFVISNDECPDYIKDMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD55</accession>
    <name>A0A914YD55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YD55"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18155.t1">
        <property type="protein sequence ID" value="PSU_v2.g18155.t1"/>
        <property type="gene ID" value="PSU_v2.g18155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="4">
        <location>
            <begin position="66"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="693"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18155.t1"/>
        </source>
    </evidence>
    <sequence length="810" mass="89822" checksum="414BF900E42CA16D" modified="2023-02-22" version="1">MDIDAVEKHQQKMREIAQKRWEKFNEQQQLNGGGAAAGAGSARLLLNNNEKWKSRTMGLFLPLRAKQIFFILNGNPGRIYRVIINPYRKFDFDTILEEVSHGLGIAILKLYSFTGERIKNIEELFDIKENRVLAVPRHERPIFPTGIQKESSASSIASAVITSSLPPINRSNLFHHPSNNRILGRTTTTHYALKLPPRQTMALRNNHSIERSPIGRDSRIPGVTAAAAAAIAPARRTFSYHKPPEAGAAGAGATRPFIPQMASTSRTRIAPPIQPFSKRAQNRRVMSLKPRRTLPYQQANRAGLPTTTLLAASAATKSSSATSKDSSTASASLEENDSDSGRPRSTDFEEATEEDPSESDSDNALRYEEEESDDDDYPDVHMDILSENDSLESPPPSRASNASRSPPDTAAQTPGSTRPPSAASQIFAIQNNDKRRDDAATTIQSHIRGHLTRKKIKPLLGAGTVGSGATAESESEEDKDNAEAAKEEEEERMMAESESEPEEEEYDDEDLGEEEDIPINDGRRNAAAVTIQAHVRGHLTRKRIKRPGTPGATTAFIVDGEDEEGGENKVVEQHFNDDYSEAEQSEHSDANSEVGRLESESEAEQSEYDDLPDEIDDDEIGKKHQAATVIQKNWKGFYVRKNLDKIVPTRLALPSEEGEAFGESFENEDEEIRLETAAPAGEPDEIINSETGFTYTAAIFTGNRWAADTESDLYIILYGDKGESEKHFLRQDSDDPKFKQGKTDEFVISTQNLGQLRKVTIGHDHQGYGGGVFIDQIIITENSEEESKRYLFQCYKWFDSGQVDGKLDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDZ5</accession>
    <name>A0A914YDZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18457.t1">
        <property type="protein sequence ID" value="PSU_v2.g18457.t1"/>
        <property type="gene ID" value="PSU_v2.g18457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF9">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18457.t1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36480" checksum="C8838BA630CD8901" modified="2023-02-22" version="1">MDSTNPCVDFTEIYPDPTNSVISITIFGIIYTHIFILVFVSTFSLSAIALDRYILVIRPHATVIRPRTAIKVATILWIIAAFVSAPYCYFMKIENYPGYCGQFCTEKWPNPLVRRGYALVLLCCQFLIPFAIMSFCYSVIFSRLRERANSKIRKLDERSQLLESSRGPEIPNEHCSVTKVPSKDQQKAVLLAKQRRTTTILASMVFIFGLSWLPHNVITLIIEYDENILHIDALNYTYIVSTIAHSIAMTNNVANPVLYAWLNPSFKQILIKSFWHIMPTSSSSRHQTNVNSTLSTRLTPNRESVIRLNNNFNNEEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEH7</accession>
    <name>A0A914YEH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEH7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17700.t1">
        <property type="protein sequence ID" value="PSU_v2.g17700.t1"/>
        <property type="gene ID" value="PSU_v2.g17700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF211">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17700.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28743" checksum="350C7791BB7F4BC2" modified="2023-02-22" version="1">MGILKKVREFDASWNNLVNIKPEILKQMIELKYLDLSGNKINYVDAEQLQHLDQLEIYNIPATVANYNITQILHVLPPLKAIDVEIKEEELNNQLKMADVRLLRKVTIRGKNLKKINIGAFEKLRGYRLDLTITNTQIDTIPSLLFNTITTISFLKLSLPNNKIHSFNPFLHTKAPILNQHGTILDSLDLQGNPIICDCKILWLKQWIEYSVEHSTNWHEINEALDKTECDAMPGIQDSLLSVYGQNDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFC4</accession>
    <name>A0A914YFC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFC4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16069.t1">
        <property type="protein sequence ID" value="PSU_v2.g16069.t1"/>
        <property type="gene ID" value="PSU_v2.g16069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16069.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14686" checksum="08D83D0678361DA9" modified="2023-02-22" version="1">MNKEQAEISIQIALQLKQFHPDKSVIVVSPYSKQNEYVKNCSKINDITTVEHSSLDALQGAERDFVILNLTISGKQNNNTFINENGRFTVAVTRARLGLIIVGDLILMQKLCSWKQFIQMLKEKKNIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFL8</accession>
    <name>A0A914YFL8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFL8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18107.t1">
        <property type="protein sequence ID" value="PSU_v2.g18107.t1"/>
        <property type="gene ID" value="PSU_v2.g18107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18107.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11715" checksum="1023E34FDF90A035" modified="2023-02-22" version="1">MRSLGNATTDPREKELIIKTFDDWGVLTSTWYEVADYLSTIEKLSNDSSFSERHRAALLSSKVVYCLGDYAGALQLALGAEDLFSLSPRPAHPEYGQQDELVLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGC5</accession>
    <name>A0A914YGC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19353.t1">
        <property type="protein sequence ID" value="PSU_v2.g19353.t1"/>
        <property type="gene ID" value="PSU_v2.g19353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037018659" evidence="1">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19353.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7998" checksum="BA763F7441D4E39C" modified="2023-02-22" version="1">MNSKFLVAFYLALVFFAVCDGECDAKCIKYCAKEFTKDPSGFVQCMKDCGCIPPSEIQDDKNANEIKESGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGW4</accession>
    <name>A0A914YGW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGW4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18570.t1">
        <property type="protein sequence ID" value="PSU_v2.g18570.t1"/>
        <property type="gene ID" value="PSU_v2.g18570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18570.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8266" checksum="193165A42C8F2F49" modified="2023-02-22" version="1">MEAKYNGEIIPKLTDQNVRDITNPDKDERIRSFLPPIPVPGYRIITPRIRNRHAQQSLTFQQNINSHNGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH02</accession>
    <name>A0A914YH02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1874.t1">
        <property type="protein sequence ID" value="PSU_v2.g1874.t1"/>
        <property type="gene ID" value="PSU_v2.g1874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1874.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11152" checksum="FC013A04655DB0F3" modified="2023-02-22" version="1">MLPEHSVRAHTKHDDKEEPSRKDNETKEKTEIEKPVGGAEKESVKDVKGEKKVETAEATKKKEEKKEPKTPKKNEIKYVINKTCMAPLKPDGQPIWCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHE2</accession>
    <name>A0A914YHE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHE2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18211.t1">
        <property type="protein sequence ID" value="PSU_v2.g18211.t1"/>
        <property type="gene ID" value="PSU_v2.g18211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="67"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18211.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24007" checksum="5EBF56135018A7D3" modified="2023-02-22" version="1">MLTNITQPRIPETYSLLVKVAESLGQSLAAKIIIDAMHDAARHLATTAATSSSEESESEGGVIKISPSLTLAPTFEISKETYNIHSGENVTIHTRIEGAPCSKVEWFKEGVLVEENDQISVITTEGHTQLVMKKVGKDNSGIYTAVATNLYGTATYQCTIHVTDSDGEIAGPYVTEIKKSEAEPTQTISNNVEIHKKHDQFDQEVIVEYLPFENIEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHK3</accession>
    <name>A0A914YHK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18961.t1">
        <property type="protein sequence ID" value="PSU_v2.g18961.t1"/>
        <property type="gene ID" value="PSU_v2.g18961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845:SF5">
        <property type="entry name" value="EPHEXIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18961.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14610" checksum="6B86D81FD69F5B0F" modified="2023-02-22" version="1">MQRVTRYPLLVYAILERVPQNSEIQRIAAKALLLANHVVRNCNEGARRMERTEQLLDIERRLIYKTADLKRIPLVTSGRYVVKNGQVLQIYERRAKGLLQTKQKTRNLYLFLFSDMLLIAKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHP0</accession>
    <name>A0A914YHP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHP0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18997.t1">
        <property type="protein sequence ID" value="PSU_v2.g18997.t1"/>
        <property type="gene ID" value="PSU_v2.g18997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18997.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13594" checksum="6D900427C1DF0A70" modified="2023-02-22" version="1">MIVGQHDTKNFNLTGKSLQKSSFFSELVNKHADKNGVVYLQSKDLNRLTRELYNKVAYDEVVSSDYIPSTQEKEVIKDLLEIFKDQQIQSKDLTEDEWDSVFWDDIFSRPDIQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHT7</accession>
    <name>A0A914YHT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adenylate kinase active site lid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHT7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19892.t1">
        <property type="protein sequence ID" value="PSU_v2.g19892.t1"/>
        <property type="gene ID" value="PSU_v2.g19892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19892.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11154" checksum="47EF3BCC9C9CBEB0" modified="2023-02-22" version="1">MSGRRIHAASGRSYHVTFNPPKTPGVDDVTGEPLLQRDDDREETVRHRLSVYREQTRPLVDYYSQWSATGDPQAPAYRKISGVGSVDEIRQRIVDALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI05</accession>
    <name>A0A914YI05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YI05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16951.t1">
        <property type="protein sequence ID" value="PSU_v2.g16951.t1"/>
        <property type="gene ID" value="PSU_v2.g16951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16951.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33534" checksum="90A7A5CB37BE2338" modified="2023-02-22" version="1">MFVSCLTLVLIAMDRFLLTLCPVKWRLAAKAPVFCYLIVWFLAILVAAPYFFAVSAEDVQLDPWTARYTPLILELCEKTKPQICLERTWHRLPFSRRTYTLTVLAIQYLLPLASLAFAYTQIGSTIRRRVKYSTTIDQSRKNILAQRNRRAVLLLLLLVLIYAIAWLPINAYNVLNVLDYIEFSQSRYIFCHMIGMLSAVLNPFMYGLVNESFRNAFIAMLRPLFIPCTKYIVVSPNLPPTNTTFSYTLNRKDDSPKYKKSSELIPINPVKTPFTLHQFTEPSSEEDQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIB2</accession>
    <name>A0A914YIB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19230.t1">
        <property type="protein sequence ID" value="PSU_v2.g19230.t1"/>
        <property type="gene ID" value="PSU_v2.g19230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19230.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10048" checksum="1A446AF9D03CEE71" modified="2023-02-22" version="1">MGLSTGVHRRRRGDRPAVAVPQPAGQARPRQRYPGTADRTGTGDRAARLIAHFSLRLRFRRGLRRALGTELSKYHARHCQQAATQHPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ19</accession>
    <name>A0A914YJ19_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJ19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2033.t1">
        <property type="protein sequence ID" value="PSU_v2.g2033.t1"/>
        <property type="gene ID" value="PSU_v2.g2033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2033.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19495" checksum="8FD5CCB32AD48B09" modified="2023-02-22" version="1">MIRQISELLPPRAEGYPWVLIYNSEKHGFSLATLYRKMEAWYEEMSPILLIIRDTHGHVFGAMVSTAIRPSEHYYGTADACFLFRFTGKVPHTRELRHYEWTGDNQFFINSTRQTLSIGAGQGHAGLWLDADLNHGRSQRCKTFDNEPLAGGDDEDFIIQFVEAFGFSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ59</accession>
    <name>A0A914YJ59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJ59"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17348.t1">
        <property type="protein sequence ID" value="PSU_v2.g17348.t1"/>
        <property type="gene ID" value="PSU_v2.g17348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="81"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17348.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36678" checksum="7766A6BD33D14CA9" modified="2023-02-22" version="1">MSNSKLSNDSLTATRERVTNILDNAPQVYDGVSPNIDPAIHGNEKALQKLCNWDVNGFPTIANFLTFQVYISQYQRDAEVRWIMEMCDKFRCDSLVFPLAAAYFDRYLCTKTAEFHEVRFISSACLFLAAKMKMAKPPKYDAIQADFPHLTTKKLFDYELEVSQAIKWNFALATPYEFYDHFLAFSPYFMMLREGFDRSIRTIYCDFDLACYDPQSQALGALYYSITNDTDFTNCLPQWFSYFQRFRYPFHSLKHIYDQLYLKKGLYPVNVLEYNTSHTYFSNYLNVEYNPNVSEIWSGSVWDNAARVPHVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJD1</accession>
    <name>A0A914YJD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent protease subunit HslV</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJD1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20444.t1">
        <property type="protein sequence ID" value="PSU_v2.g20444.t1"/>
        <property type="gene ID" value="PSU_v2.g20444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003964">
        <property type="entry name" value="PRK05456.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20444.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11928" checksum="EEB6B99433865895" modified="2023-02-22" version="1">MHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJH4</accession>
    <name>A0A914YJH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJH4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20491.t1">
        <property type="protein sequence ID" value="PSU_v2.g20491.t1"/>
        <property type="gene ID" value="PSU_v2.g20491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20491.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17226" checksum="79F01A97C3988E9F" modified="2023-02-22" version="1">MAEIVHALLSDAEVALFARFARACKLRAGQWLFQRGHRGERMYVILEGQIELDFGEDLVIKTLGQHEFSETGPAGRRSPAQRQRARAGRLRCAGAGPGRFPPAGRIRSRPGGLLPAPHDHARADQRTGTDQPAAPAQPRSGNRAGQPVHHHPPVDPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKD6</accession>
    <name>A0A914YKD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19332.t1">
        <property type="protein sequence ID" value="PSU_v2.g19332.t1"/>
        <property type="gene ID" value="PSU_v2.g19332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19332.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="21782" checksum="FA4B58360A1D04B2" modified="2023-02-22" version="1">MADARVDHLHAGIGQALGQFVLQVLGDLAGMAAQGQLAILMLVVRIAGGHRAQRRFGLDVHEALVVVHVVDRFGGIDHLPDDHRGDLDRAAVQLVDLQLAALEVAHALADPALGKEGVVPAQAVVLHRAHVLAEQAQYRRLVGLDGVQAGQDEHAQRHQQGAQQHQQQVGRAGSGLGCHAQYEQGCAGEGDEQGAGQRAEAVEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL00</accession>
    <name>A0A914YL00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL00"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19552.t1">
        <property type="protein sequence ID" value="PSU_v2.g19552.t1"/>
        <property type="gene ID" value="PSU_v2.g19552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19552.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12480" checksum="4AF74993D366CF51" modified="2023-02-22" version="1">MIGLLDQNVSPNPWAQQQQRDQQQQQQQQQQSSSSSGNGSGSGSGTSSSQIPKISPPIKALDAMDEEVEDEEIQLPLRDEENNDEFDYPQRFEPMDLDDEIIIDCDNHFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM20</accession>
    <name>A0A914YM20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20616.t1">
        <property type="protein sequence ID" value="PSU_v2.g20616.t1"/>
        <property type="gene ID" value="PSU_v2.g20616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037136307" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20616.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="7550" checksum="61DF8073CC4A82C4" modified="2023-02-22" version="1">MNFLTTLFFFIAALMAVNAQFGFGSGMGGGFGRGYGGYGGRGYGGYGGRGGMYGGRYGGMGMYGGRGMYGGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN94</accession>
    <name>A0A914YN94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YN94"/>
    <dbReference type="WBParaSite" id="PSU_v2.g188.t1">
        <property type="protein sequence ID" value="PSU_v2.g188.t1"/>
        <property type="gene ID" value="PSU_v2.g188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g188.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33145" checksum="F5CE4F92A90EAFA1" modified="2023-02-22" version="1">MKLISLASVIVRILFHRGSSGSEKIISALLPAINTIFNHENPKIQILALGSYDFFTDENYAKLFIENGVVKMCIGFLETSMDSNRFEFIMRFFQKMIDEGSDSDIQYFIDNGILRNVQKALKHFNEDVKLVGICLITSLVQSANGTQKHIIFNEPNLFSSIVNLLDHKNPSIRSSTLELLLKYIDRANSKEIIFSMFDSSNCIYQLCALLKENEMPVTILRILQNLLFKADNKTALNIRDILIDCKAEATMKESLSDDSTFLYAANLFSEFYDLNFWEKRAMSKSSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPF2</accession>
    <name>A0A914YPF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21513.t1">
        <property type="protein sequence ID" value="PSU_v2.g21513.t1"/>
        <property type="gene ID" value="PSU_v2.g21513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21513.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43239" checksum="C2D55AB9FDFA1080" modified="2023-02-22" version="1">MSIFNNSRENWIENPDDDIEVLKHAPQIEGSDSDDENPAVRDFKQREAAALQKPRNNGIEATTTTIPAVSEDKKRLSSAELLVAGAFGGGGATSVNHRGGTIGGSTPATSSSSSSKPNQKQQQQQYAHDEGHDSDMSMSDSGRSDDDFASTSSNTRYVEEMLDDFRTINDLPHQEYTTLFTKVNNIRRELPIGQNEEMARLLDCTYQLVIRRRDRSIRVEDFLKLMSHCFDKILTDNNVREWTEATHVLDNIFKALLYVFAKYDGFDHLKKVIESRLIFNCENENLDMLLRVGKFLSAVTCHLHVQFCSTSSAFAREILKLLNEATDAKWMYKELKTLIDSPLLELTLVTKEVAAVLLNRQTIDRELIRQIDDVQLRFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPK1</accession>
    <name>A0A914YPK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPK1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20931.t1">
        <property type="protein sequence ID" value="PSU_v2.g20931.t1"/>
        <property type="gene ID" value="PSU_v2.g20931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20931.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8703" checksum="D94CA522B2CB34C3" modified="2023-02-22" version="1">MKTVQARQDAQDYESELVNDYKRELVCKAIASEDIINYSNERANRFTDIGFEECVAFLRKHAPEELDAVLAQYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPY6</accession>
    <name>A0A914YPY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21525.t1">
        <property type="protein sequence ID" value="PSU_v2.g21525.t1"/>
        <property type="gene ID" value="PSU_v2.g21525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21525.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36232" checksum="63DBB1A6D92460D4" modified="2023-02-22" version="1">MSTKNHVDHIFRRSLLLSKLFTKSWGAPKTLERLLYFRQNFIGQGRINELIENKKPIMVITKEWNRKDITYMEGNFISPLFEWCPQLFPAGVEKCYWRGLFPHSSKKRNGLVIHLAGTGDHTFFRREYGFANDLLKEGYSAILIENPYYGTRKPKQQFSSSLLNVSDLFVMGAAIIGECNFILRWAKESGHWPLGISGVSMAASNVHDPIALVPCLSWTTAAPVYTEGALSDAIQWKNLGKELSSKHFRDAISQIKDCDWLEQLQDKESFDRQTEDSKRFMWILMEEFTNLNKYPVPFEPSLVKAVIAEEVCSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQI6</accession>
    <name>A0A914YQI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NlpC/P60 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21315.t1">
        <property type="protein sequence ID" value="PSU_v2.g21315.t1"/>
        <property type="gene ID" value="PSU_v2.g21315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051202">
        <property type="entry name" value="Peptidase_C40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47053">
        <property type="entry name" value="MUREIN DD-ENDOPEPTIDASE MEPH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47053:SF1">
        <property type="entry name" value="MUREIN DD-ENDOPEPTIDASE MEPH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21315.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14601" checksum="9D31732E9EA2BB63" modified="2023-02-22" version="1">MNKLMQQIGKPYRWGGSSPRTGFDCSGLVYYAYKDLVKIRIPRTANEMYHLRDAAPIERSELKNGDLVFFRTQGRGTADHVGVYVGNGKFIQSPRTGQEIQITSLSEDYWQRHYVGARRVMTPKTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQY1</accession>
    <name>A0A914YQY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQY1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19784.t1">
        <property type="protein sequence ID" value="PSU_v2.g19784.t1"/>
        <property type="gene ID" value="PSU_v2.g19784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037424784" evidence="2">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19784.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30794" checksum="ADEFB182E3131C6F" modified="2023-02-22" version="1">MLNLEVFFLVTLAIIVKICCADPLQCDVFDPACRARIQASNSHSVRTKARNQCHYQDIWLIPGRADSSCTRPDAKRLVDIDPRQVHIKPAVVKFPGCFTLEIRNMRVHDHQDVLSNSFFAKSEYQWLNVKEFGDVKCQNATSNGCGGYGNNCYYCDICESLQAIDRDELTPNNEGTFAEQFKGLNCPRKAGYYTFRKEFCFNDWSAFDTDGDCQMDFLQSDKSDYKGALQSLQQIGYGTVIAKIRMAYNATGGIQRKKSTKEAQIERTTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRT4</accession>
    <name>A0A914YRT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRT4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2884.t1">
        <property type="protein sequence ID" value="PSU_v2.g2884.t1"/>
        <property type="gene ID" value="PSU_v2.g2884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2884.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41087" checksum="931BD667C88745CD" modified="2023-02-22" version="1">MMPRSRRGFQGAGASGGGGAPERVRTHLLFSSQAEHHTAKRKRRPHNKFHQMMHKKDEMIQASPDELDPSQWTGNQRVLHFGPMAQRDPFFYYYPKGWDVLYPAQFGFFPYRTNKFRGSSSVVCVWAFGAFLIVGGALMIYLGYFVQYDTPFWHLPGWTFPTETTEEFIFPPPIQVAGPIIFGIGALLIFIGMICSCTTSQFLNERLRHYHHRGQPASVTVYTTHTQQPRAVYVPDPYQPLPPPAYPVLKNKYAVSNVVDPQAEMKLFPPVVQGCSTLSLHGRSPSVFLGSPYNTLRAVSMTKLPQPNAQTQDLGTTFTNYRADSAIVEGSRRQSSITSMNASQRRAKSLGVSRNRRRQDSAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRV9</accession>
    <name>A0A914YRV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRV9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20131.t1">
        <property type="protein sequence ID" value="PSU_v2.g20131.t1"/>
        <property type="gene ID" value="PSU_v2.g20131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052322">
        <property type="entry name" value="Mito_rRNA_Mtase_NSUN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955:SF3">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955">
        <property type="entry name" value="PROTEIN CBG01349-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20131.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8272" checksum="A55360AC93ED254A" modified="2023-02-22" version="1">MGLRLILLLCITDFAFAVTALPYIIHYLALWNPNYFDYNPMFIIVSSIPLLIQFKINLIITIAIAVDRLQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSE4</accession>
    <name>A0A914YSE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3637.t1">
        <property type="protein sequence ID" value="PSU_v2.g3637.t1"/>
        <property type="gene ID" value="PSU_v2.g3637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000136">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3637.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39346" checksum="C8B1C7B4B67F5C07" modified="2023-02-22" version="1">MYICNNDHFKVGSWSYQADYVRIIADERDVFLGDFYDNQEWLLVDATVDNGTLTYLENETFSMVYVNIIIKRQSFYYVFNLVFPTTLVGLVAVVGFHAPINATGRRESKFRLGIMTLLSLSVMLLMLVDEMKFAFESIPGQRGSFSEVPVIGIYYMSLIFLISVATCTTSIFVHLEKYALRNQHFTAIPWVLRFLAAKKLFCCYVPRGLNFNKGDETRRNKNIQMRSNHSSLDSAAFRTLIPTQLNFTEYQQQAQEQIITETVLSAQPIVPPQDNQKLDLLISLMREFLQVKREVRSFHTLPVYWERVIKRLENISLCFYISLIALNLLMFLFPEVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSN9</accession>
    <name>A0A914YSN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSN9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2667.t1">
        <property type="protein sequence ID" value="PSU_v2.g2667.t1"/>
        <property type="gene ID" value="PSU_v2.g2667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056709">
        <property type="entry name" value="DUF7807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851:SF5">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25093">
        <property type="entry name" value="DUF7807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2667.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26704" checksum="420EC63BBA56008C" modified="2023-02-22" version="1">MTKTERQFVKVEKGEKVEIIAIEPFQHNSPEYKCCCNAIHFKKGAAIIGILTIIAALITITLSAIWNYWWPIIPAIIFLGTAVFILYAHKSEKQNFYLPYSIITGILILTAFLFVILSIVLIIFIPTWSQDFVQNVRSREYADEQQKHDATRVFYTWLIIALLIFILIGSWFVWVVYKAFMYMRDMHLARHPYKFLYTNGIKDGLEHTQNSGMSGPPQHHHTNGTNVEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT04</accession>
    <name>A0A914YT04_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probably involved with other LSm subunits in the general process of degradation of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YT04"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3290.t1">
        <property type="protein sequence ID" value="PSU_v2.g3290.t1"/>
        <property type="gene ID" value="PSU_v2.g3290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3290.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16047" checksum="379EA269E4105847" modified="2023-02-22" version="1">MELPEPFLPGAISLLEQLDKKMMVVLRDGKTLVGYLRTIDQFANLVLHNTVERIHVENCYGDISRGIFLVRGENVVLCGEIDEENRPNELIQVSVSKILEMQQAKFDLKREQDQAKIEAMKGRGKLPQIRNPSDILGEDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT05</accession>
    <name>A0A914YT05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YT05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20566.t1">
        <property type="protein sequence ID" value="PSU_v2.g20566.t1"/>
        <property type="gene ID" value="PSU_v2.g20566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF405">
        <property type="entry name" value="PROTEIN CBG12249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20566.t1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39223" checksum="FAB3504359CA76B8" modified="2023-02-22" version="1">MGLGEDFISPAQTSFINRWYSPTEMARIGAFTITGKALAGTVGFPVSSYLCQLQEIDGWRLMFYTFAILGGIWIIIWGIYATSSPSKHRCISSEEKEYILEELKQLEMNHDPDDPKLYKGSIPWKSILTSKAVIINLICQFTFNFSEAILSAYLPTYIDQVLKLDLNQNGYFAMISFFAQLIFQILFGIFTDMIHKKDVISGTTSCKLCQGLENFLCALSYLGLGFLANKDHLFLAGMFLVFNGIGTAASVGGFMTAQPSLAPQYAGIISSILRTTAALGALSSINVVGFINKEGTPIQWRTIWIIAASLNVVTGIIFLIGGEAETQEWAKNDETENDKTLSSRKSSTEHPLTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT99</accession>
    <name>A0A914YT99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3912.t1">
        <property type="protein sequence ID" value="PSU_v2.g3912.t1"/>
        <property type="gene ID" value="PSU_v2.g3912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="198"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="416"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3912.t1"/>
        </source>
    </evidence>
    <sequence length="541" mass="62472" checksum="FA01F97CEA1E0E09" modified="2023-02-22" version="1">MIRSRELWEQCADWLLEAKIELPNVSKLQLRDLAASLKDGVRLCKLANTLKSGCVEYRHIYNIQGSEFTQEKNVLLFINALRDSFGFQESELFDSSDLTQFEGFKKVINTLSRLSHTPEAVNRGLKPFPEATSPSTFSSTSSGDDIYCNLQHQIDPDDEAIYGLCHYKNESDNDDIYDKIVAHRPGKSEFEKFVPSSKKQFQIKELLETETNYLKNCLEMLINDFYRPLKCCLATADYKKIFRNIHDIYLLHSSFHQNLQTAVHKALGISKNDINIDPEINGIGDVFTKHKSQFLKYAEYCANMDEAREKLDFVEKTDAQARRKIQELLKESKTDFRLQDLLTVPFQRICKYHLLLQNIVDSTTEQSMERERLVAGLKACKDVVDYVNEAKRDDDNQKVIAHIERSIIGMNAIGCDFYLYGRLKLDGVAKITDFIDNQSKSKQRYVFIFERILLICKKMKNEIFEYKASYLLSNYTIQDTQAESPTSTTKSTSTLTRLKTATRFDYNTFTLISSPNGHKIQIDLKSPVQKKAWKEAIEYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTL9</accession>
    <name>A0A914YTL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectinesterase inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTL9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4027.t1">
        <property type="protein sequence ID" value="PSU_v2.g4027.t1"/>
        <property type="gene ID" value="PSU_v2.g4027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF6">
        <property type="entry name" value="TPM_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037528584" evidence="1">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4027.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18398" checksum="F995951118E1AF68" modified="2023-02-22" version="1">MKLLISALFLSIFVFGINGKSWDSSNFPNPTKRGECIVERHAYLCDPDMLISPNGRDKVVKALNDLERNSRNQSASSFCDKQGVTAAIAAGKDFKGSQKELDNIASDLYKKWRLDNECDKSFVLLRSGTSSDAKYAVEAGKGVPMTKQEIQKLFKKILSEYYGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUG8</accession>
    <name>A0A914YUG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUG8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3310.t1">
        <property type="protein sequence ID" value="PSU_v2.g3310.t1"/>
        <property type="gene ID" value="PSU_v2.g3310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3310.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11709" checksum="B5CE8BBE525F6F25" modified="2023-02-22" version="1">MNGWLRPILSKSQQVSFDRVLQSKIHHYRHTITQHKAVEMNRKRQEDAVDATTAVHLGHTQAVAKTNYVGSQDHHLIARIMPDKVSMLKELHDNTDWCRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUX0</accession>
    <name>A0A914YUX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUX0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4406.t1">
        <property type="protein sequence ID" value="PSU_v2.g4406.t1"/>
        <property type="gene ID" value="PSU_v2.g4406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4406.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38517" checksum="EBB20FA8D09CD76E" modified="2023-02-22" version="1">MCSKVNKKEVVEAVTVIETPPLVIIGVTGLIETPRGPRAFKTVWAEHIAEDARRRYYKNWYNSKKKAFSKSSKKWQDEDGKKSIESDLNKIKKYCATVRVIAHTQQKILRRRDKKAHIIEIQLNGGSVSDKVDWAREHFEKQIPVEQVFSQDELIDCIGVTKGHGYKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPSRVQFTVARAGQKGYHHRTEINKKIYRLGKSCLTPEGKKNATTETDVTEKNINPLGGFPHYGLVNQDYVMIRGCCIGPKKRPITLRKSLIDHKKRFAFEKINLKWIDTASKFGHGRFQTKPEKKAFMGKLKKDMLAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV19</accession>
    <name>A0A914YV19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3822.t1">
        <property type="protein sequence ID" value="PSU_v2.g3822.t1"/>
        <property type="gene ID" value="PSU_v2.g3822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037413660" evidence="4">
        <location>
            <begin position="23"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3822.t1"/>
        </source>
    </evidence>
    <sequence length="514" mass="57680" checksum="D1C4A51AC6C8144C" modified="2023-02-22" version="1">MIALKYANILLLLICWCSSTVAFTETVEENVYYVCGEEIQEPDCICENEIMTCQEEANYGKNFKSANVVIIKPNFVAKNVTFVRSEITALKINQILPGRESTVEKLVISARSLRIIENGVFDNFTSLKSLSLIGTYLNNITDAVFTKKLGSTLTELDLSFNEFKLLSSINFTHLTNLKTLNLYGSKFGKNVSTSNLFPQALANLETLNLGISGFEVLNGSIFVNLVNLKTLYLAGNPLTSMPTAINYIPSLQNLYLDETLITVLNNTGIKINKNLEKIVMTNTNLVSIQDCAFCSFPNLKYLNFWDNQKLTFIDENAFGYAKNGSLPKIESISLEHGNLQIIPEKLLDWKNVREIGIGGNNFMCNCSLAWLVNNIDDLNLVQIYGHPLGMRPVGEGYRGHRAYYYLARSRENNLECHGPMALEKIHFSLIAGNLCTNHTHQNEHHHQPVAPHHIVCYFLCGIIVFAIIFAAISNPLSQLYAKLRNPKTTNPLSYENSNFDADSEVVNNTENRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVT0</accession>
    <name>A0A914YVT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVT0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4091.t1">
        <property type="protein sequence ID" value="PSU_v2.g4091.t1"/>
        <property type="gene ID" value="PSU_v2.g4091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037318540" evidence="3">
        <location>
            <begin position="18"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4091.t1"/>
        </source>
    </evidence>
    <sequence length="681" mass="76870" checksum="FE9E3BDB150309B2" modified="2023-02-22" version="1">MLIVLGILLLIFKDATACTCDGIEITQSDQKHCYQIIRNTGNSWVTADEKCSLFGGFLAHFNSTTLYNQLHDYILKNYELPLMTGATVANVELDLVALMCPSNVFYSLLSNSFVSSFFEGSPTKNDRCTFIVNNGTNKLQYMSCNTKGDILCDRLTTTIQPIQTVTSLTTKIPTVITTRASDSDSCGSGYTDIFGWCVPWWCWLVFGLLLLGLLLCCLSWLFHFCCAVCLCSHKKELPIEKNVERQWQREDEICQTDPFVIPSNNEAVYIPVPKTPPLPHENALIKEREQPVNTHTILHTHEIIREKSTIPPPPPVVYDVTIYENAFNKNTILVPPIVHETQASPNIFLPPSNFEHYNALSQRRIPDDDIISANSIPFFPEDFKTPSPIPLYTKDESDPVPFLPVLAAPTVMPVMPLKPPKKKKERRPVSPLKHNRPPLGSQFDDEPKPKKPFHDDARDFPKPPPRDVETPKERAFPQPPPPRTPENRKTSPDEYFDRPLRKNTPLNLNKQPERLSVSPKPNERAPAMPRLPHRSPFEVPSPTDEIKPPKKKRNASPPITIFEPPNSLSQAPKLSNQRRLSPMHDEPPRLPSSPRKFSTPPPQKTFVADDISSKSISTPTPSSQRPRRRQSFDDRDTPNQNDVSMRAPRGRLGGANDKPDGWKPWAKSSQLFSGHPGFLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW32</accession>
    <name>A0A914YW32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW32"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4774.t1">
        <property type="protein sequence ID" value="PSU_v2.g4774.t1"/>
        <property type="gene ID" value="PSU_v2.g4774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4774.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8378" checksum="5E144F13B48B5BE9" modified="2023-02-22" version="1">MLRDVRKFFAVALLPFLKFNFFTNEAGTEAAAATGMMMMAMSLPPPPEKFVADHPFLFFLADKNQNIHFTGVHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW37</accession>
    <name>A0A914YW37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW37"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3868.t1">
        <property type="protein sequence ID" value="PSU_v2.g3868.t1"/>
        <property type="gene ID" value="PSU_v2.g3868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3868.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14152" checksum="5622C3306D8005B2" modified="2023-02-22" version="1">MVFEMFMLSTNESPNIVSTDNDRASTKVAENTKVDTRNDHTLNDSLQLNDTSLNETTTTNRFRFRKRSHANIFHDISSDSDSSLSTPKKSKLQNIVITADYEFVECFRHGSVRKRLFDFYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWF4</accession>
    <name>A0A914YWF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M13 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWF4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4299.t1">
        <property type="protein sequence ID" value="PSU_v2.g4299.t1"/>
        <property type="gene ID" value="PSU_v2.g4299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4299.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26642" checksum="D25B194C139BB530" modified="2023-02-22" version="1">MTRSIDDKIPICENFYRHTCGKFHFENPSNPNQLINYKTRLDDGLEKEIHDLLTAPSTQPSFSLQFSKGLFNQCSDFSLRESIGAEPLLSLLRNLPCGPLFPGCNGFNEKAFSWERSSGMMDLYAGNLNIIVFDKDTNSQNPQEIILSFKAPDFSMLLDDSKMRIESLQPQSASEFQALLSVQLKGTIINSTITELFGFRWDKNQQGQLEEMIQLLVNLDEVRNLYYFAFNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWG7</accession>
    <name>A0A914YWG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWG7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4313.t1">
        <property type="protein sequence ID" value="PSU_v2.g4313.t1"/>
        <property type="gene ID" value="PSU_v2.g4313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF13">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="14"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4313.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23181" checksum="81BC22907727391C" modified="2023-02-22" version="1">MEFTKKNRYGKYISDITVRHLLEHTAGGWNNLESDSAWVEPQLSTKELIEYVLENVPISEKPGTKWIYSNFGYQLLGYIIEKKSGISYEEFVKKYIWGEVGVTEIQVARPSLTERARREVLYYMSGNKVGFNPYEMLSPERIGPWGGWIASPIELLQFMAHFDGFDKKEDILSKDSIDEWAIATKASNDTYGMLLKKIDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWV4</accession>
    <name>A0A914YWV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4444.t1">
        <property type="protein sequence ID" value="PSU_v2.g4444.t1"/>
        <property type="gene ID" value="PSU_v2.g4444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4444.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9400" checksum="B22B506C4A3BC2D1" modified="2023-02-22" version="1">MADLYGTESGQNGGEGFEVNPIFQSDTVETWHGNNYPVNPHNEIQQFQAFEDLTMDQEVSNNSMHNSDEEYFLKLFQDFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXE7</accession>
    <name>A0A914YXE7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXE7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g478.t1">
        <property type="protein sequence ID" value="PSU_v2.g478.t1"/>
        <property type="gene ID" value="PSU_v2.g478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040426">
        <property type="entry name" value="C05B5.4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057569">
        <property type="entry name" value="C2_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626:SF4">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25330">
        <property type="entry name" value="C2_nem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037271751" description="C2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="35"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g478.t1"/>
        </source>
    </evidence>
    <sequence length="437" mass="49091" checksum="B120AB7430A4D941" modified="2023-02-22" version="1">MKTLYYHIFILSLFAIVNASTTVMASGMEAPEGAFWLTTELIGVTFTPGCLTTKYCVKPTFKVIQTLLNVPETPTMSWPINENLTKDGREHTFVTYWTSGEPKYVSFNVEIVGKDPTFAFSRVCDQSPETKVFQPDNAYLRQALHPRLLCLFPALRARRHLGNDHKKVPAQVDDSPIEFTLVGQCFNATFAVRKHLERCPWCPDHNLHVSLSNVVEPENENIDMASFIANNGLLYSIIILIASFLITVTGIIICACIYCCKRKTLKRTKSERSINKTLYHQRALPPNHFHPAMHQTLLKNRSNYDEDEHHYTMPMVPSETMEHRYETPWDRKYRPIQQYWNPSSVSHKSEMTVTSPIESSSALGSISTDRTTIGGGNSGGSLPGVSHYHSGSFINGVTHGMINSDGTVRMSSNFQNTSPISATTHCSRHDDSGHDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXP3</accession>
    <name>A0A914YXP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IF rod domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4728.t1">
        <property type="protein sequence ID" value="PSU_v2.g4728.t1"/>
        <property type="gene ID" value="PSU_v2.g4728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000058">
        <property type="entry name" value="Intermediate filament protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF6">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFB-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="146"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4728.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27760" checksum="9231E374CD5C9204" modified="2023-02-22" version="1">MLQARWKQLTDEEKRLNTDNLRLWEELTKARNDLDEETLARIDFQNQVQTLMEELAFLGRIHEQEVKELQALLERAPANTRDFFKNELALAIRDIRNEYEFVAEQGRNDMESFYKLKVSEVQGNANRNAIESKHQREETTRMRDTINESHARLGDLESRNAQLENELKNLNYQLNDDQRQYEQALNERDQTLRRMRDELGALMAELQALLETKQMLDAEIAIYRKMLESEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY16</accession>
    <name>A0A914YY16_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YY16"/>
    <dbReference type="WBParaSite" id="PSU_v2.g297.t1">
        <property type="protein sequence ID" value="PSU_v2.g297.t1"/>
        <property type="gene ID" value="PSU_v2.g297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="354"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g297.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="59132" checksum="ECFEA9CB5C7FC5BD" modified="2023-02-22" version="1">MSINQRPFALFGDVCTNVNEPVAMASKYWDILHLSYAETHAKFSSADAKDQYPTFFRMIPGDRNLIAARCHLLLSYNWTRVGTIKQSDDPRYALPHEKLTTTLENVYNIRVIYTAGISVDQEHNIGYELDELKRRDARIIIADFSPDLAIKTFCEAYQKEMYGINYVWILHGYHQNNWWKYTESTNCTVEEIEKVLQGHFALAFAPQRPDSNKAITSNKTVKEIKEELKALCDRRRCQYDAYSAYAYDGIWTLALALNTTLKTTHDVSPDLTSTKLLQALAQTSFEGVTGKVKFDHNERLGVAFIEQWWNGSYHNIGYYDNANEIFTIESTFEWIPPLDATVVIREKQYISYFLFAIMSSFSLFGVLLALFFLFFNIKYRNHRFIKMSSPNMNNMIIAGSICTYVSVFLLGIDTRNVSEMLFEKLCYAKTWVLSIGFTLAFGSMFSKTWRVHSIFTNIRKDKKAIKDYQLFMIVALIMAIDAVILGLWAVISPFKYSITDHEEIVGFIFFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY24</accession>
    <name>A0A914YY24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g4852.t1">
        <property type="protein sequence ID" value="PSU_v2.g4852.t1"/>
        <property type="gene ID" value="PSU_v2.g4852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037847835" evidence="2">
        <location>
            <begin position="22"/>
            <end position="2504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4852.t1"/>
        </source>
    </evidence>
    <sequence length="2504" mass="276223" checksum="B2A66DBD26443351" modified="2023-02-22" version="1">MWPPLLFFSIIFGLLVGPSLSARCLAIKQNSLFDRHQELKEVRPCNHYSNGIGEGCEVIIKCFQDYFFRNTQYAEGQRLTCQGGAWTINGKASAIAACDKGCKVLRESELLGMRNATFVVGPPKDEFRNGDDYYWPRGTHIETKCKSGYDFDDSKNREKGKDTHTCLGGDEYWRNDNANKYTGSRPGLCLPTCDQITDIPKSVEVVLKPGDEYLTDTKRVLSNSIYKFACKSGESLDCRKNQTLVCRGGVDGYYDPYNGQTRQNVFTCAAKTCPPYKNNDKNAVVFAGKKDCPRNHDGEVPEECEITIKCKEDFYYAEPKDGEGRVVVCKDGEWIDKNTGKAPSNGNACQKGCKVLNENDPQGLKNATFVGKGKPEKMFKNGKDEYWPAGTIVETKCKENYAFDMPEDRKRGQDKYVCVGGDDFWNDGFKNKYTGGRPGLCPPLCEAFDKKKLPPGVKITLDPAESDLIEKVGDKTYVYSQSIYKFKCDDGYKYPSGKPEQTLICRGGDLKYYDSETRKFNAELKECLSDGCPVISAANIDKNAVITSSNDKCKSNGDTSPDGCDIHIQCKAKTHFFNSPDYPEGQKLTCKKGKWEDQNGKAVEPKNGILSDRCVGGCAALIDTDMPNSVFVGSKPKGDFEVHKNGKDEVWAAKTVIATKCKPGYGRPDPEDQKHEPNRYICDEGGWTNLATNDANQKPGHCVPLCKLPALQEGTKLTSKLADSFKTEVDGVSYVYPKTIVKVQCEQNYKPPENVKYPDNTQQLECKGGDEGFFDPTSKKNNSVPMVCKKVGADGCNVITPQIIGPGADVTSDKCEIKDGLAPIGCSVTIKCKDGFYASGSGEKTPEEQTLKCKAGVDGWVDPKTNVKNATHIICLPGCDAVDNMERATIVGDKPSEKDVVTVDYVPKTGIEREEPAISYKCKGGNKDAPWVNEITGKPEANPGDTCSKVCEAVKKPPTGVTAIQSPGYFEHKGKSVIVEGDQYAFKCADGYKYPASSSPAAKGKQTLVCQGEPDGFRDTDNNKTTKKPQACERGSPEGCSKLDVQNPPTNTKVAESNGCKLQNGLTAPGCKVTLECAKEHYPKSPVHQKDGKQDLECKDDGKESHWNDQTKKVVIDFLECQEGCSVVDPLKNAIYTKQPAPTVKTGGQNMYAPGTLVTIKCKPGTVPAEGDVDDAEKPTEYECKGGQKGWLNKNTGKNEEKPGDSCLTVCDALTPLPEGVRAIQLAAEFMYRDKMVVREKSRYTFKCADGYHYPKGTPQAKNNRQSAICDSSNARFVDPDSGSNDTFTRPLACDREVGEGCQDLAQENGKVSTEQCPAGVKSRGNGCKLTVECKEGYYPEAPNYQKNGKQELTCKDGKDWVDQNGKLVNTKLFCLPGCLITPEDKKVSKVAGDSGNNVKVDNYIIYKPGAIINVTCYGDGVVWKNDVTDTKNPHSYECKGGDNKWERKDDKKSTVTIGEGCVNTCKVESLKVPDTVRQVQTAQTFEHEGESLIVAGSSYIMKCKPDYEYPKSSPYAPTGKQTLRCDGDNRKLEDKENASNKDGKIIDCSPKDGANLCKDLPQDTETTQTHVQNCEKKGDYYPTGCKVEVACKVGYYPKDPEYQQQPGTQTITCQSGGKGWADQGYRPVQKPLECVKGCIKTPINSATNTDKKTTTTNFIIGNEQVSCTVEETTVTTNSTSSANDNAFYCPRNKTDGTTNNVVDKSCDNACAAVLSPFPEGVKLQRLVGHKLDVGKKSYVHNNAQYIFQCASGYQYPKNSKHKPQGNQVLKCNGKTNQYDDPLTGVENTPIQPCEKVKGCEEIQQNPKQSQTKVVSCTKDGDTVTNGCKLSVHCKPGSYPKNPKYLRDAAQELTCSEDGSGWVDQNKEKINKPMECIEGCIDGSAKAVIISHTLDKNVTEDREYMYINDMNGVTIAECLTVDTIKRELERIIRKQADDHKFYCDLQDKIEKDKVDFYYDDFCKDACHEIMKPLPANVKINKSPRIFPHGDRTYVPNNDKYELTCADGFQYPSATPAADKGKQTLVCNGKSHRYDDPDSGVKSAKPIGCVPITGCKPLRNEDDGTVVKKNKCSLKGAVYEYGCEITTYCKEGYYPENKKLWKNGGQDISCKIGTGDKFVNENGSPVENYMKCIKGCVKRSESSHDTIIDENREYTTVMNYEGKILAKCASMETIKREIEKRKNQHNKFFCQTNETKNENGTSYYDDYCNNACRTLQEPLPFGVVIEKKAPIFPHAGNTYTIQNGVYQLTCQSGYSYPKNSPYAEDNKQTLKCDGASHQYKDEKTGKLNPIVQACVKLEGCKSLGRVSDGTKQSRHNCQNQGKEVNKGCAVTVTCEKGYYPSDEKYFTSKKQTLTCIEDGSGWADQDGKLVSAPMTCKKGCLPRPTRPPSTGTNSETLEMTYNLPGGVTVYCNYKTVTQDTKIEYEGKDSEYYCKSSNGNDPEGNGSETKKTISPCSNACKALSPPSGAKETSDKPRPPLVFDKVNYVKDGHKYVFFHVQVAKRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYU0</accession>
    <name>A0A914YYU0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BUD31 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3201.t1">
        <property type="protein sequence ID" value="PSU_v2.g3201.t1"/>
        <property type="gene ID" value="PSU_v2.g3201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00998">
        <property type="entry name" value="G10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3201.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17372" checksum="26CC5B7A0A922C5F" modified="2023-02-22" version="1">MSLNVKLRRIRRKPPAGWDTIESTMEEFEQKMRDAETDTHEGKRKSEAVWPIFRINHQRSRYIYDLYYKKEEISKELYDFCVDAKLVDPQLIAKWKKQGYENLCCLRCVQVRDTNFGTNCVCRVPRSKIDAERVIECIHCGCRGCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ86</accession>
    <name>A0A914YZ86_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gluconokinase</fullName>
            <ecNumber evidence="8">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZ86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5807.t1">
        <property type="protein sequence ID" value="PSU_v2.g5807.t1"/>
        <property type="gene ID" value="PSU_v2.g5807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000522">
        <property type="entry name" value="Gluconokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007336">
        <property type="entry name" value="PRK09825.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5807.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20155" checksum="17558A204721F8DA" modified="2023-02-22" version="1">MGVSGSGKTLIGSKVAALLSAKFIDGDDLHPAKNIDKMSQGIPLSDEDRLPWLERLNDASYSLYKKNETGFIVCSSLKKQYRDILRKGSPHVHFLWLDGDYETILARMQRRAGHFMPVALLKSQFEALERPQADEQDIVRIDINHDIANVTEQCRQAVLAIRQNRICAKEGSASDQRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZU9</accession>
    <name>A0A914YZU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZU9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g602.t1">
        <property type="protein sequence ID" value="PSU_v2.g602.t1"/>
        <property type="gene ID" value="PSU_v2.g602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046163">
        <property type="entry name" value="DUF6165"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19662">
        <property type="entry name" value="DUF6165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g602.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30535" checksum="8B63AD8144EFCE26" modified="2023-02-22" version="1">MRDLQPGALLPGHGGIEFGPVQRTAGTRIHVAGQVGVQCPVRCQRAGPARHQVELAARAIVRFERNVGTPDAGIPARRDRDLRAGLHRRVAIALRAAAPHVIAGQCSTATDLHLCLRAAHAKQPCQGGHHRRHHPLAVHCTVFLVEGGTNRVDAILTPVSIGELIDKITILEIKAERINDAAKLANVRTELDGLLPLLQQQLQAQPALAVLKQQLKAINERMWDIQAQLRDKEAAQVFDDAFIQLARGVYGTNGERVQVKNEINRVAGSALVEEKQYQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0R9</accession>
    <name>A0A914Z0R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0R9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5478.t1">
        <property type="protein sequence ID" value="PSU_v2.g5478.t1"/>
        <property type="gene ID" value="PSU_v2.g5478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5478.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41394" checksum="D64462E600B2F348" modified="2023-02-22" version="1">MFKKIDPDSETQIPSPLDLFVSKPVNVAFQDTNIVEYSPLNSNGAVPIRFSINSGSTYLDLSQRRLGIETSRNFDDLELGGFAEDDETTQTSGVGFEKRRNNFIINSEFNTIAHLDVDFFKQKKFLLNETLIDIELTPNNTDFMLIVQDKTTYSLAIIDYKLYVKQHHILPQIDEQIQISLKTDSLAKYPYTRNIVNTHYISSGRYDYKATLFNDFIPKRIFVALVDGKAFNGTLNTSPFEFKQFNIQNIHISANGKLMPNYPYDLDKHDFSRCFKDLVETTENTGLSYEEYLTHTCIFAFDFQSHPLKNVSELQRIGTTALSIKFSKAVPIHGIQVIVYTEFDSLIAFDYSRNMTTSFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0S5</accession>
    <name>A0A914Z0S5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0S5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5744.t1">
        <property type="protein sequence ID" value="PSU_v2.g5744.t1"/>
        <property type="gene ID" value="PSU_v2.g5744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="483"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="615"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="803"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="903"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5744.t1"/>
        </source>
    </evidence>
    <sequence length="1087" mass="119387" checksum="4AAD3FCF2CD71772" modified="2023-02-22" version="1">MQRLILSFNRFEAIPVQFGDLKNLIELDISNNGIVDIAPEIEFSPHLVIIDLSSNVLSAGTLPKSIVNLSNLTHLNISNNPIAELPEDIDNLQNLRSLDARQCDLRQLPASIVKLRQLHRLDVGENNLAELPADFDGLENLREFDAEENDLIILSSSILGCTKLESLVISENRLRELPADIGELKNLIELNAHSNEIEKIPSSIRLLTNLRILRLNNNMIEMIPQALGSLSALNELYLNGNQLQAIPSSIGNLKKLSFLNISSNHITALPTTIGSLENLGSLLIRSNKLQELPSEIGKLTKLRILDIVDNLLEDLPYTLLVIKDTLRALYLTADRPMKIGALKECRDKNNIIVLSHYMLPQKNYTIPSGENKSTVGGSRVYFSDDVPPMASEEEINISQEDKGLGNFERFDTPHPKQFGQKYQKALQAKRNSQDMTGMFENNQNNGGTSEVDENLVQMRPLRSVLKTRPQSTISASMETGETKTVIVRRQNGTIGWNIYGGIDCRIPFKGTDHGFFVSKLEVAGAAEQSGIVIGDKLLAVNGRPLKGLTHDQCVNIIQDAGDLIEFRIESESAEKLLQAESKISVVSEGPPTSFAPPIPTKRDNEEPEVSTDVISVPIKCEFNGDPGFTICGGTASMPISIKDIIPHGPADSTGLLRPGDRILSVNGTNVKMARPEQVHALLKAVNADLELYLVVERVHFKSTQNLVQSLLAPSRSMPSLFLPHLTSDESQSAFTPYHVKQKSHGHARKPSGDFPANYFVDLTHEPRSAFGPNRSKSIDHLVLAVQQNSESKANQSFDCTALVSPKHEKSQSPKPSQLRQPNVFAPKKVISPPTTPISTPEPLAASSPAPTLSNGIQVASTSRIPQPSKIPPPVAPKPKTSITAKPQKPETLAFNSKIKRFEELQQLPSASTSTSTKNGYIPPPKKPLLSSSDLQKLKESEQLRMNNNTPKLAEEEDIDDVTPLEEYEQKLNYAVTTPSMPAIVRTKNAEMRQKAAEAAANGGVSPAPSSSSSSELQRSDSAASTSSLRKLDPQEIEKQKRWREARMKSVEAASLQAEGFLNELRQISRLSNISEDRSIQPSPIPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z113</accession>
    <name>A0A914Z113_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z113"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5585.t1">
        <property type="protein sequence ID" value="PSU_v2.g5585.t1"/>
        <property type="gene ID" value="PSU_v2.g5585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5585.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36553" checksum="3BAC5F4AEB994C6C" modified="2023-02-22" version="1">MPIIEDPFYASFAASSSPPVRLDIDSLYEVFDQFVQMAPIHNAVALRSANWQVCRAINYALYKTTTISIELKWHKDRLENPEPQIIIQGSQIRSIEKAEECIDFIFSHARLITQLSIDIEVSGAGKYLIALLDKFMGRENVQLEVLKVRRRYIGESFPVISDLIYEHASTLKVLGRIGLTEAVEGFTQKLHLERLSLMNFDLIDDGTMDSPMLFEKTRYCMRKIADTGATFEHLSYTTYCGFEIARQPTLQFLRSGEVQSLRLTMQEGNPLPYSDRIILDTLKSLEFVGDMEIESDNLARQFPNLSHFDFIRQNLACCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1K6</accession>
    <name>A0A914Z1K6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z1K6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6592.t1">
        <property type="protein sequence ID" value="PSU_v2.g6592.t1"/>
        <property type="gene ID" value="PSU_v2.g6592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF26">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="468"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6592.t1"/>
        </source>
    </evidence>
    <sequence length="1030" mass="116062" checksum="9EE89EC3E4E5635A" modified="2023-02-22" version="1">MDQLLGSALPEHVIAAVRNQLGVNIPKLVIYARIFGLETLLSQLSVQDSARLLNEFSVKIDHLVKRNNLVRIQSDAIIVVSGIPEHNTTHAESACQFAWELMHVLRSFCDATTAELYIKMGIGIGTVSAGIVGANKWHYEVIGEALNIAMKMEQKANPGCIILSNETAEAVKSTFGSERFDESSRRLIPTARVASTIPNTLLFPNHRRFSLSTIPQAINRLLLASTVAPVPGQKNDSMVISMSVGEKTLIQRRRKKKMKYFSDEKIDEPDDSDRIINSWTLQFKDTEIEKNFNMVIDRWFIPALAISIFFLIVYGLYQVLVMPRLIASLALIIITLAAMFIILLMLYVNHFETFCYFITRTFLVLVEWRIEYDLLISLTTFALIIYFQARRNERIIRLDFLSLLRSMEEACQLERYERINEQILINALPHHIAYNFLHRNSAEPYCQLCLSVGVLSIKIGHPSDWKGEAGINRLNQIIYQTDRSLETYLGLEKVRSTNGYYTAAVGVLPEITRNIHDTPFTIGDLLASLTSFAINLKQMIEDEGLEVSMGIDCGSALSVVIGAERPRYEIIGPPCNRSMQLMENASEYASSEKSINDSESALHMLEETTQCTSLPMDQSFSSCPPHDPQHFVPTIPATAITIGVTAHNPLEMFTSMNSSMSSDMYSIDVSVESDSEIEWITPESIIYEKLGSKEGSSAANNDMNLTRFNRRFLPSSRSISYKGDRVKQYSDFSENDRESSFTLSEKVKRKRFKPSLSRNGPRVPTWLNSKSSLNSELSLSLNRDGSVTALEKLNAAARRVDKMLQELAHVDENEYWNGNLKNPFPTNFAGLNTSTRSINLENRRELSSACHTEYDNAESEGACSDPEVVTSSRLEELKHVLRGFSSRGNANEEKRKQTSERFFQRKYNRPYDAGNEADIDSNCSSVASSTILDKLRWKSVHSIGYENEYEFASDIEENIVNINMLPALRCKPKTKSVGDDANFLPMDASDSENENQLTTTQNEVTALTQDIYKNFGEYQLSTFSDMDASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1R4</accession>
    <name>A0A914Z1R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1R4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5836.t1">
        <property type="protein sequence ID" value="PSU_v2.g5836.t1"/>
        <property type="gene ID" value="PSU_v2.g5836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5836.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21853" checksum="E4A82AC37C68A38F" modified="2023-02-22" version="1">MTKSMETIEAEESKIFTAKVSTIKELNSRGNETATSGKTSAANIGKELKEMIGLLLTFKTSLDAEVANHGNKESSVTELNVSKAEIKKLQTTFKESCSKCSDLKESIKKDKEAKRQDADEIARLKAKIAAKTKEMEKENLEFQEREKELDAQIEAIEEELFRKKRFMEAELANPTPNFLFEGGEQSRSFLFDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z204</accession>
    <name>A0A914Z204_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z204"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4284.t1">
        <property type="protein sequence ID" value="PSU_v2.g4284.t1"/>
        <property type="gene ID" value="PSU_v2.g4284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4284.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12795" checksum="005550A57FC5C351" modified="2023-02-22" version="1">MEPILHCRVPNGTVHDIIEELTLAANCTEHSTAYLIDRTWLLTIAIEYGFVILVGLYATVRGIFRFRQKRLRRNNGHHLIDDPQRPHSATLESQYPGKLIQDITSEGNSAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2P1</accession>
    <name>A0A914Z2P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Centaurin-gamma-1A</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2P1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6338.t1">
        <property type="protein sequence ID" value="PSU_v2.g6338.t1"/>
        <property type="gene ID" value="PSU_v2.g6338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF5">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="431"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="11">
        <location>
            <begin position="659"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="817"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="555"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6338.t1"/>
        </source>
    </evidence>
    <sequence length="941" mass="105965" checksum="3253A06AC21FC702" modified="2023-02-22" version="1">MQDPRDHGSGTRNSQIPRYPVSDQIRQEISRFESVHPCIYTCYDLIDNVADAELQEQLRQSILHIEDAFVNSQEWTLCRTVNDIRLGVIGSHDSGKTSLVHKYLTSNYNPEPNAEGGRFKREVLVNNRSNLLLIREEGNSAPSAQFTHWLDGVLIVFSLHSRDSFRKALLYYQKMDNYRPLKSIPVILIGTADLITGTGTFPRAVAEDEGRKTVMQYNMYSYHETNAAYNKKVNDVFKEACERIIFEKEMTRIGARQFQDQLHISDHRNAYHQRSMSSHLSHRDGVIEPRLPPYMADSSRYPKQLPSYHSQIAPQFSNVTPAHSHNNLSSQNSAPNPYYRSSSSLHPQLEHWNANDSFDASIPASLASTTSLHQPLSIASTSHLQTPTSTPTTQRKNRRISHLFRSGNKDHHTENRITKPPECSVGPGRLIPIKQGNLYKRSSKALNKEWKKKYVCLHVDGRLTYHPNLKEYMEKAPGKEVYLGLATVRLSNRNKQKPKSKNPPTVSVPVTNGKENMNPPLEENRSANGTSTPGDATSGASDDQQQFVLLTSTSSSYVGQPTTPAMDKTAPPSASSSIKSSSSKKKRAGHRRLSSMGIKMDDEEDTEFEIITNDQKKWEFSAATVEERDQWVSLIGKQIEKTLQEQTSQKETDSGHYCPEEVTRLKEIDGNDICADCGKKDPVWSSLNYGTLICIECSGIHRNLGSHVSKVRSLELDTLPIGNVAVLRAIGNKLANSVLEHNAPRTNKPQPNSSHELKLNWIKQKYEQKKWLPPLPVDRTLSAQLLNAVMDRNMEDLLKILPRCSEKDINSHLNPADHRTALHIAASSGATEVVQLLIWYNADIQYTDQNKHTPLWHAEYNGQYECRDVLLSAAKSTVSNSEPMSSSTLVSGSSYMPFDQQPAHYRISDPYTVRPMPSYSSHNRTIISQTDDFDTLPTSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3Z1</accession>
    <name>A0A914Z3Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DFDF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3Z1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7415.t1">
        <property type="protein sequence ID" value="PSU_v2.g7415.t1"/>
        <property type="gene ID" value="PSU_v2.g7415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7415.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13424" checksum="96565C9E99D061CC" modified="2023-02-22" version="1">MIMENSCRGTSSSRFTPRENNYNSQQRPRRGRGNEFNPGNRELIDFQARYDAGVAEQKQNTFFDPEFDIDAEEEAALAASKANLFNSALENQTAATINVPTQATSNQPTIKGRFYNRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4B9</accession>
    <name>A0A914Z4B9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4B9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7539.t1">
        <property type="protein sequence ID" value="PSU_v2.g7539.t1"/>
        <property type="gene ID" value="PSU_v2.g7539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7539.t1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50619" checksum="A52067E12222DCDB" modified="2023-02-22" version="1">MREIVHVQAGQCGNQIGSKFWEVISDEHGIQPDGTYKGETDLQLERISVYYNEANSNKYVPRAILVDLEPGTMDSIKGSPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMSSFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLQNPNYGDLNHLVSMTMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMPGFAPLSAKNLSAYRAQTVAELTQQMFDAKNMMAACDPRHGRYLTVGAIFRGRMSMREVDDQMMAVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADNDGEEEYADESALANQEQDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4X0</accession>
    <name>A0A914Z4X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4X0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7025.t1">
        <property type="protein sequence ID" value="PSU_v2.g7025.t1"/>
        <property type="gene ID" value="PSU_v2.g7025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7025.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8542" checksum="77C6DC7CF9852B2B" modified="2023-02-22" version="1">MDEACGGGSRDDDTHGTTPLLRGRRATPSPTLKAGKKRHFIPPHGSQSSLPSYEAIMSQPRSRKIRHEQSPHTSPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5H0</accession>
    <name>A0A914Z5H0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z5H0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7596.t1">
        <property type="protein sequence ID" value="PSU_v2.g7596.t1"/>
        <property type="gene ID" value="PSU_v2.g7596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000518">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="119"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7596.t1"/>
        </source>
    </evidence>
    <sequence length="433" mass="49810" checksum="FAF2D7394EEC4036" modified="2023-02-22" version="1">MSECYYHGLLPREDVQYLLKNNGDFLVRVSQPRSNDVGRQIIISLLVDKDAETNIGLRHIVVRKQMGKYQVEESPRFDLIQHLIDHFMKSGKPISPTVGNTVLVTPIGRQKWELRHSDIELTKRLGAGVYGEVYRGKMKRRNHMMDIAVKTARTTVVTKEGIKEMMREARMMRNYIHPNVVRIYGVALDEDPIMIVMELVRGGSLQEHLRSNSAKITDTERLNSMASSASWGLEFLHSRSCIHRDIASRNCLYDRSKNVKISDFGLSREGETFKMTTTQRVPIKWIAPETLTTFTFSKATDVYSFGVLIWEIYNNGIEPFEGKKTSEIKAMVLNGERLEFPSTTPPEIKEMVTQHMWNKAEERYTMIDIVKRFEQLSGVKQPPPKQRNNKGSLKTIGRITADESNVSMETSSKGSWSTKKLKKRRSKFLFRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z882</accession>
    <name>A0A914Z882_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z882"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8103.t1">
        <property type="protein sequence ID" value="PSU_v2.g8103.t1"/>
        <property type="gene ID" value="PSU_v2.g8103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8103.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14330" checksum="1267109BCCEA9B93" modified="2023-02-22" version="1">MDSTTDKVYNGFVFEATIIEWSFRSPSVTTVIEDENGDTERLTVYNWPLNGDPKAKFIDAMKAFRPGTMVSIINPYMRMANDGQSMIRVESPAYIRLDCQKLDWTEFNHKEICKHLKMYAKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8D7</accession>
    <name>A0A914Z8D7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8D7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8161.t1">
        <property type="protein sequence ID" value="PSU_v2.g8161.t1"/>
        <property type="gene ID" value="PSU_v2.g8161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8161.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15060" checksum="698258BA8F0A9E56" modified="2023-02-22" version="1">MSSSNWSWTDNTTFDFKNWAPSEPQNLSMSCSALTIQNGYWASSDCFKIKPYVCEISVPAPPSTTQSYPVYMNCSAGWAYFEPTHSCYGHDGYGKITNNWTESEKLCLSQGAHLVSLHSYDELKFVSSIFHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8J5</accession>
    <name>A0A914Z8J5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8J5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8169.t1">
        <property type="protein sequence ID" value="PSU_v2.g8169.t1"/>
        <property type="gene ID" value="PSU_v2.g8169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8169.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12734" checksum="B094D814DBB7B087" modified="2023-02-22" version="1">MRSLGQNPTEQELLDMVNEVDIDGSGTIDFPEFCQMMKRMNKENDSEMIREAFRVFDRDGNGYITADEFRYFMTTMGEQFSDEMVDEIIAEVDTDKDGQVSVIEVFYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8V3</accession>
    <name>A0A914Z8V3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8V3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8761.t1">
        <property type="protein sequence ID" value="PSU_v2.g8761.t1"/>
        <property type="gene ID" value="PSU_v2.g8761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000345">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF16">
        <property type="entry name" value="CAVP-TARGET PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="76"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="186"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8761.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37865" checksum="19EA0411787F8F44" modified="2023-02-22" version="1">MLKINQLKNQTPQKLPHQRPDGTLKLIIQSAKAEDIGNYRIEVINKVGKAVSSAPLKHAEEKKIEEPKQEKAGELPKFERELQPQTVKPGETAVFEAKLSQQSEAPKVQWYKDDKPINASNDMLIDTRTDGTLRLIIQRAQSDSAAVYRVEVINKAGKATSSAPLKYAEEKKIDGGKEENVEDVKPFFVQPLKTQAVKEGDTVILECRVNEDSHPEVQWYRDDIPIDTKPNILIEHRPDGTLKLTVRKVRSEDIGEYKCVAVNRAGKAQTEAPLKYAQMIDLKLPDDEEVSLIDEETAEEPQRLKVVQDKNTAATEGISNIHAEYVMITGVKRNNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9X7</accession>
    <name>A0A914Z9X7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9X7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9474.t1">
        <property type="protein sequence ID" value="PSU_v2.g9474.t1"/>
        <property type="gene ID" value="PSU_v2.g9474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="entry name" value="TonB-dependent receptor, beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="Beta-barrel_TonB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="TonB-dep_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="FERRICHROME IRON RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="FERRICHROME OUTER MEMBRANE TRANSPORTER_PHAGE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52016">
        <property type="entry name" value="TONB_DEPENDENT_REC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9474.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13420" checksum="BD21DEDF78C14F5E" modified="2023-02-22" version="1">MRGPVSVLYGKSSPGGLLNMVSKRPTTEPLKEVQFKAGTDSLFQTGFDFSDALDDDGVYSYRLTGLARSANAQQKGSEEQRYAIAPAFTWRPDDKTNFTFLSLPERAGNRLLRLVAERGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAY1</accession>
    <name>A0A914ZAY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAY1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9819.t1">
        <property type="protein sequence ID" value="PSU_v2.g9819.t1"/>
        <property type="gene ID" value="PSU_v2.g9819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9819.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17418" checksum="6A847E308706D867" modified="2023-02-22" version="1">MSGGSKKLLTELTKLASMSISSSKSAYPAALDITQTAFHEPKPLFANDKKPEVAKLMEKSIPIFDKAFESLNGGSNPDKRQKAQISRSGLQFMVEEFESNQDLYRKIQPLLNASGVKSVEEYIQKTTTKEQAKNPGMDTSKIPVSHFWWFNVEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB94</accession>
    <name>A0A914ZB94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calnexin</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB94"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9190.t1">
        <property type="protein sequence ID" value="PSU_v2.g9190.t1"/>
        <property type="gene ID" value="PSU_v2.g9190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038168032" evidence="13">
        <location>
            <begin position="23"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="505"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9190.t1"/>
        </source>
    </evidence>
    <sequence length="614" mass="68988" checksum="1579BB81C94B2467" modified="2023-02-22" version="1">MKFYLFLYLGLIVTTFITGLKAITDEDDDDVETSAANQYIPPTFIPPTLQEDEVHFLDWFPDHHGIGKKWLKSKAKKDGAEVDLSMYNGEWFIGAPVNIVAENDFGLVVKTKARHHAIAANLREPFDFSGKPLIVQYEVKYEEGQECGGGYIKLLSAGAEKQISMFTDRTPYTIMFGPDKCGQSAKVHLIFKIKNPKNGTISEHHIKESGKNLVSYFEDKQTHLYTLKVTPENDFSVQVDNSKISSGNLLKDLIPPVEPEKEIADPSDVKPETWDEREFIVDPEAVKPENWDETQPKEIVDENAVIPSDWNEDEEPLIPDPKAKQPEDWDTELDGQWEAKLIDNPACAGISGCGKWSAPMIPNPEYKGKWIPPKISNPEYKGKWTPKMIENPNYYEPNPYKQLEKITAIGFELWTMSSGIIFDNILITDDENIAHRFAAETFTIKKDLEGKYTSAKNPSTGIFQSLIDATEDKPWLWAVYVIALLIPTILIAVLCFGRKTSSPVTTAAAHHKKTDERDDEDEEEEEIENIEPEAEVHDDKGEEIVEEEDKEETPVVTYASVVEDGGTKSDAESQKSGKSGKSNKSHKSPRASPKVTASTAATTAAPRQRRPRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBB4</accession>
    <name>A0A914ZBB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GH18 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9945.t1">
        <property type="protein sequence ID" value="PSU_v2.g9945.t1"/>
        <property type="gene ID" value="PSU_v2.g9945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073:SF4">
        <property type="entry name" value="GH18 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9945.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26809" checksum="3B1D2980F5F29F27" modified="2023-02-22" version="1">MFKKDSSQAERLTHLIFAFFRLNSDGSISLGDVQNGTNQKAAKIAQERLTGMLNVAKKFPNLNIQFAIGGWDNSEFFTLLVADFSRRKVLIESIVKIIDSYGFDGVDIDWEYPVTGGDSEVFMHFQADRRNYVHLLRELRTRFTDYETQNSLPKSLLISFAGAAGQWTLDPGYDLPMLLKYSDYVNVMSYDYFGAWKSKWGAYTGPPAPLFFGQPKKFSGKMNVDWTQVFFSSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGS0</accession>
    <name>A0A914ZGS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZGS0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9482.t1">
        <property type="protein sequence ID" value="PSU_v2.g9482.t1"/>
        <property type="gene ID" value="PSU_v2.g9482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="97"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9482.t1"/>
        </source>
    </evidence>
    <sequence length="505" mass="58310" checksum="5040F1DC2D27C433" modified="2023-02-22" version="1">MVLGRTPSRILMNLDDSNLPSLLHPTPPCTPCEPSASSVATPFYIRQFTFLNGKIPDATVFQPEGHPKQAIIDGEVWPPIFKTEYVRSAKMLEPRNDDVFVCTYPKCGTTWIQHICSQLLLDNYGPEKGKELSMTSPMIERMGAKYSDELQYPRLLKTHFAYFNCPKSQTAKYIFAVRNPKDCLVSYYFHNKNFKIYDWPEGDFDTFFELFINGQLAFGDYFDHLISWQEHMHDENVLFLKYEDMMEDLEDAVKKIGLFIGGNAEEKVTNPEELNKIVEESKIDSMKKNQERWFPGSILRKQTFIRKGGSRDWKNYFSKEQSDRMDAVFRTRLAGTEAEKWWKYEMSWNELLPEIMLTEADESDEGMYSDDTDDLPPSVSRRPSNANILAVYKPVRRDSFQSFATYGSAWTRSRSSSIGSQASGSPPQLCIVQQTLPETSSSSSDQQQPKQQQQFKQPKNLLSAACAEYNKKERKKIRDDMVKSLKVDLIYPIFIVEIFLGKNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHH8</accession>
    <name>A0A914ZHH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHH8"/>
    <dbReference type="SMR" id="A0A914ZHH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9749.t1">
        <property type="protein sequence ID" value="PSU_v2.g9749.t1"/>
        <property type="gene ID" value="PSU_v2.g9749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000019">
        <property type="entry name" value="YRDA protein yrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF56">
        <property type="entry name" value="PROTEIN YRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9749.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20226" checksum="7F1603574A1498FF" modified="2023-02-22" version="1">MSDVLHPYRDLFPQIGQRVMIDDSSVVIGDVRLADDVGIWPLVVIRGDVHYVQIGARTNIQDGSMLHVTHKSSYNPDGNPLTIGEDVTVGHKVMLHGCTIGNRVLVGMGSILLDGAIVEDDVMIGAGSLVPQNKRLESGYLYLGSPVKQIRPLSDEEKAGLRYSANNYVKWKDEYLDQGNQTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS92</accession>
    <name>A0A914XS92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XS92"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10852.t1">
        <property type="protein sequence ID" value="PSU_v2.g10852.t1"/>
        <property type="gene ID" value="PSU_v2.g10852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10852.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20256" checksum="C38F18D1265557AD" modified="2023-02-22" version="1">MLGAREDILKDLEIEEVFIKSLCDNYTFEEREKSLLNNIYKEKIKDFKEPPTVITDSIFEAEWDALSDDEILQIIEEKWKNFDIIQSFKMKLNKIDIYGETELHRAISSDATDLNHIKFLINECGYDEIIDKSDFAGITPLMKAVNIDRTDIVQYLLEKGAKSDATMRNTNTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTZ9</accession>
    <name>A0A914XTZ9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11432.t1">
        <property type="protein sequence ID" value="PSU_v2.g11432.t1"/>
        <property type="gene ID" value="PSU_v2.g11432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11432.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="16795" checksum="23E677970A174CAD" modified="2023-02-22" version="1">MTTADQLQKAIIAAEEAAYGPFFGSLGVTAAMIFTAAGSAYGTAKSGTGIASMSVARPDLVMKAIIPVVMAGIVAIYGLVVAVIISGKLNTGGKAYPIYTGFSQFAAGLTCGLCGLGAGYAIGITGECGVRALSQQPRCFVGMILILIFAEVLGLYGMIVALILGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUN3</accession>
    <name>A0A914XUN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUN3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10241.t1">
        <property type="protein sequence ID" value="PSU_v2.g10241.t1"/>
        <property type="gene ID" value="PSU_v2.g10241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18572">
        <property type="entry name" value="ABC_6TM_TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000154">
        <property type="entry name" value="HAlF transporter (PGP related)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF19">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038007942" evidence="6">
        <location>
            <begin position="17"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10241.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33712" checksum="7E0564DCFD03ECE2" modified="2023-02-22" version="1">MCALCLISAITGGLRGGCFSYATALVNNKMRSDLFKSLIYQEIGFFDERKTGEIMSRLTADCQTMSSTVSTNINVFARNMIMVIGSMIFMITISWRLSFAVFVTAPLMGFITKIYGSYYDKLSESTQTKMADANAIAEQALGTIRTVRSFACEHKEVERFEEKLIATLKVNAQKSWAYLGYASLNEFGNNATLIAILFYGGHLVLTGKMSGDALFSFLLYQTQIAENVYAIGWVFTGIMEAVGASRKVFEYMKREPKIKNNGEFIPPHVYGKIEFNNISFHYPTRPQTIVLDVSYHPSLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUT3</accession>
    <name>A0A914XUT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUT3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10726.t1">
        <property type="protein sequence ID" value="PSU_v2.g10726.t1"/>
        <property type="gene ID" value="PSU_v2.g10726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000007">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF104">
        <property type="entry name" value="SERINE PROTEASE PCP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10726.t1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55914" checksum="645B6E2E1E663A16" modified="2023-02-22" version="1">MPIDHIHGSTQKTFQLRYFFNLDSYKPGGPLFFYTGNEGYLESFAQNTGIMWDLAPKFNAAIVFAEHRFYGYTYPYGNLSYTNIKYLRFLDVEQVLADYVVLINNVKRTLINDTTAKVIAFGGSYGGMLTSWFRKKYPNVTVGGWASSAPLIYFKDGGVPVDAFSHITKTTFVASGCDANKIPNGFSAIQRLAQTDEGRKKIDRIFKLDKNSLLQSYDDCWNVIYYVQTAIEYMAMTDYPYSSSFLQPMPAWPVEESCKGLMATDNSDEGLVQGLYNIANVYYNGTGTLNETCFYNCPGAHDALGSPDGWPWQECTQIIIEMCDSGPPNDFFWKDCDASNVFDSQISYCFEAFASRGWSTSQIKENYVKNTFGFDYAGVNNLILTSGTYDPWYSGCLKRNLFDFQTSFQRGLYVFELEGSAHHLDLRQPNTCDPKNIENVRYQITNIMWCWAYPKDSKCTQINSKPTELPPFIKKTVECKPIIYGYPWGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUZ5</accession>
    <name>A0A914XUZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10363.t1">
        <property type="protein sequence ID" value="PSU_v2.g10363.t1"/>
        <property type="gene ID" value="PSU_v2.g10363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037379540" evidence="3">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10363.t1"/>
        </source>
    </evidence>
    <sequence length="529" mass="60874" checksum="4CEE2BDCC1B24AF7" modified="2023-02-22" version="1">MTKKFSILLIIFEISIIFATFNPKTEYIAYNYDEIPFKYRKNIISFNDGEIKFQMPSEFRGRVIFKSMNSFKVSFYRHETCQLPFEGGIFYEGGTEHPFEVSYGSGPFPECTWRMYWWNFYDGLTYKTSSLITAAKFDGNDEYVKGFNGPTNEINPVTFSYDRGRNMTFCGGKWSGNGIFYGVYTSRPCISLGMAYNETHRIYNIIVRKLEPKCKHEITISEGMFLIFSNDDHPNTIKGPEPFNIPKWPPGNRIYVPLQFEGIFVAAISFATVPLIAILFGIGCIILTTFIKIPYFYTKNAIERSEEKKKEFEGKNKKKWQKYKETRKDFREIIEKSQHLKPSQPHGYEFEDEPIKMRVDWKDILDSDKKELDRIREYYKDNQKLPKWLSKDVLKKDFEYPPPIDVKLQKKLTTKAPLFTSIAQKVVIKVEDGEVSATKEKKEAPPSQASASVIIKDISKAPSKVASKKGPDVSKKMSAKETQKATEPTFETEAEAAATAKKAQTDVTQDVAVHTVVTQEENPEDAMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVG1</accession>
    <name>A0A914XVG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme NO-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVG1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10523.t1">
        <property type="protein sequence ID" value="PSU_v2.g10523.t1"/>
        <property type="gene ID" value="PSU_v2.g10523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF16">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme NO-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10523.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11580" checksum="A2BD48B5E68D373B" modified="2023-02-22" version="1">MFGFIHESVHQMMIRRYGDDFWIAVLARTGFEMGKENIVNHYYPDGDTYALIDSVSALAKIPREQVWEMYGAFLIEYTMEIGWDELLRTMSPNLKGFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVP9</accession>
    <name>A0A914XVP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10602.t1">
        <property type="protein sequence ID" value="PSU_v2.g10602.t1"/>
        <property type="gene ID" value="PSU_v2.g10602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8206" evidence="3">
        <location>
            <begin position="278"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10602.t1"/>
        </source>
    </evidence>
    <sequence length="544" mass="62809" checksum="0B8EB911A5F93FAE" modified="2023-02-22" version="1">MKVNHKIMKPTIGKDDENEGKYLPGESCTQEPKVYRYVTDLYTFNLIDTPGIGDTRGIQYDIENMKMVIECLSLSDEVHGICLLLKPDSHRFVPPLRYCLEELLANLHQSSIPNISVVFTNAGSTLYGYGNTLNILKTFVKEVQERSQNVIPLESKNIFCVDNEAIGVIYGHYKGETFKDEVIVSSTYSWNHSVKETHRIFDYFTSLTPHSTNATKATNQIRQVLWELYTILTDLNDKITQNKKILDEQTQQLKDLEEHLAARQNVNYQGVEVQNTRLSNPTTVCCGAKCTEQIKSPNSCVLQTFYKQSCCLSCHLRNVNENQIGHANLRQCTIFDQNANCKSCGCSWQSHMHFWYSQKKIETQFSHPANQEEINRLKLQIAAKPNYMQQLKTTIYNFEQSYKSVQSLCRPFYEFLSQNSIITVNTAFEEYLKRESEVAQNSSKHEKVKLESLEKLRLIHQEQQFLIASLKGADTSTDQKISLLNYVEKIKSLEKIGSQIFDSQNYQRLFKRHMYKLVRCSTTNKLSDTRNQLSEGSPSEHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW57</accession>
    <name>A0A914XW57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XW57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1120.t1">
        <property type="protein sequence ID" value="PSU_v2.g1120.t1"/>
        <property type="gene ID" value="PSU_v2.g1120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043988">
        <property type="entry name" value="CCZ1/INTU_longin_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19032">
        <property type="entry name" value="Intu_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="34"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU second Longin" evidence="3">
        <location>
            <begin position="225"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1120.t1"/>
        </source>
    </evidence>
    <sequence length="490" mass="56306" checksum="8BBDEF45EA148D10" modified="2023-02-22" version="1">MERVLYGKKTAYMMSPGYSATTPKSEFLKLIDLMEYFFVSRPASGRREGFEYQRVMYFNPETENSSKQTDVSGVAEAFIAFTENFRKRAEVVAEYDHRFVKSTKLLEIFVQVENSEYIIGLGLNRQACNEHDYFVHMSSLKALLIRTYETFRLFYGTFSDLFETGKGILMQRLDQFFSHYLSLLRVHQIPLIDLFSGVGFMNMPPVDYLDVQCLISRCSESFPMIKKTLFLYQDKMVEYSVSKNDIIVVYRYLTQHLVQSAVQSELKPVASATYRETETKKFIGKFITGVTEDFIGQEESVDHQFPNVFLSDDNGKMISHALIAYRALNATFCLFVKNEDMPSLDLQELQQSLDSELSRLASNIGDNVSSITRTITSSDIPFHYVYYNPDSLSLKTSFVDSPSDLSNVPLPPPAIYKQVCETFDHFIDTDTEKFAQVCCKADDDWWVVVKKVNGRVLTLFIPSTPTSNITDIHDIVEQIIKSYFLNLFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXM5</accession>
    <name>A0A914XXM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Co-chaperone DjlA N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1128.t1">
        <property type="protein sequence ID" value="PSU_v2.g1128.t1"/>
        <property type="gene ID" value="PSU_v2.g1128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="TerB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Co-chaperone DjlA N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1128.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7300" checksum="87AFD57DF7FE0191" modified="2023-02-22" version="1">MVYADGDVGEIEDNIMWRIAELIGVDQQQRIGLKLRVAERAQSMRDALASLPKAEAQNSAEAEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYI1</accession>
    <name>A0A914XYI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYI1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12015.t1">
        <property type="protein sequence ID" value="PSU_v2.g12015.t1"/>
        <property type="gene ID" value="PSU_v2.g12015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12015.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="23735" checksum="12839654A5B4DA70" modified="2023-02-22" version="1">MKAMREIFIIIFVFGILIARIESLSLAKLANELCRREPQRSYCKEIQAADAREAEEAANEEEESVRRAPIDFANLASQNSGGAGGTPIAFGRSTGNNADFEVPGLGSLGVGQTVSDIAKFIPRGTADDTPNGGTFNIGDSKYGFSQGETGTGKTRHRTDTISLGGIGTFEVGKKAEQGAGIENFLDKFIPKIPEPPGGIENSNPLIREEAETSRSNYYSNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYP2</accession>
    <name>A0A914XYP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XYP2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12329.t1">
        <property type="protein sequence ID" value="PSU_v2.g12329.t1"/>
        <property type="gene ID" value="PSU_v2.g12329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12329.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44133" checksum="80CE9179111BF39D" modified="2023-02-22" version="1">MAFLRQTAKSASKAVYQTANEIKRRMSDVATLDMSPKARKYVGYWLLACSAGVYVAVGAGGLTRLQESAMKMTDRHPFRWLPPFGQKAWEEEFENYKKFDEYMLLTPEDRGELTLEMFKFKWSLVYCHRMGGRSLFFLFMGPCIYFWKKGYFNSVLKKRMLFAGLLMAAQIPIGWWMLNSGLHRELMANKEKPGVSQYRMATHLVVPFMMYGVFLYSGLSMFLKPQDHSNVAKIGQLRFLGKGLIAMLLVGSGMGCFLTALDAAEPEYARKWLPDDLFVMVPKWKNIFENPVTVQFIHRYLGYISFAVINATYFIGRRMHLHPRAMTALKGMMALGYAQLVLGVSTLYFRDPAILAWLHQNFSIILFTFLIWLVHEIRRLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0F8</accession>
    <name>A0A914Y0F8_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0F8"/>
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        <property type="gene ID" value="PSU_v2.g12698"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12698.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15117" checksum="6B75A0A51CD0B2F6" modified="2023-02-22" version="1">MNLEIIVTLLIPLIKRTLVFVKRTCIADYIAIRLDAYGIPAVSIHRQLVDVQTPIDMFNKGEVNVAIVTQYFTRGIDTEVDVVINYDLPIIAADFIHRCGRTGRNGNIGIAITFIDFLDPENYNPDVIEQIIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0L0</accession>
    <name>A0A914Y0L0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0L0"/>
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        <property type="protein sequence ID" value="PSU_v2.g12748.t1"/>
        <property type="gene ID" value="PSU_v2.g12748"/>
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    </dbReference>
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            <begin position="79"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12748.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20842" checksum="1AF07704FDD9227B" modified="2023-02-22" version="1">MYSPLCYFSQLESFMRGHGTCPSPSCGTDPKVKEGYRLDFPDFTPHEFVQIMKTKVWADNANERWTMAEIAHGLEKLTSLPRPRFNSGSDGMHPGHHPAAQSPKQHHQQPQQLFNGDDNQQHHQDSKKGSGRQKIRKTRDHLSESSSNESPKAVDRQSRRQKGKAKYARKFSKNKQKSKKGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0P9</accession>
    <name>A0A914Y0P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0P9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12362.t1">
        <property type="protein sequence ID" value="PSU_v2.g12362.t1"/>
        <property type="gene ID" value="PSU_v2.g12362"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12362.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23759" checksum="DE7E923168A2B242" modified="2023-02-22" version="1">MTKNETNSNGPSILAKGCRRCRLSKCLEAGMKVNGMPEAAPAPEAAPAITDPELEKNSLFAAVIYTVLTTAVTSPNLMVDYLVEAKQELFSSAFAKMPGIDFTSLPEKIYFLRCLLSLCPVQTHEFSVFMQISICQIQLQWLSKEDKFLLKLMQYEAMSNLNKSNLTDNRVNELKELSQNLLNVFFVNLSLISFSLKFGYGEVEVIVKFCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1L1</accession>
    <name>A0A914Y1L1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1L1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12671.t1">
        <property type="protein sequence ID" value="PSU_v2.g12671.t1"/>
        <property type="gene ID" value="PSU_v2.g12671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="1">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12671.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14928" checksum="A1CD464A9B6EC813" modified="2023-02-22" version="1">MFVLERNQCGFNAEHDAGWRYPTVELLDRRPFFASEDIYCILDMDEGYLSFATNKKYLGVAFRGLKGKTLYPIVSCVWGQCEITMKYLGVCEPEPPSLMEACRNSILERLEKKKNMLIQFVNFHFQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1Z1</accession>
    <name>A0A914Y1Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Piezo non-specific cation channel R-Ras-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1Z1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13250.t1">
        <property type="protein sequence ID" value="PSU_v2.g13250.t1"/>
        <property type="gene ID" value="PSU_v2.g13250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="3">
        <location>
            <begin position="317"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="4">
        <location>
            <begin position="579"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13250.t1"/>
        </source>
    </evidence>
    <sequence length="686" mass="78858" checksum="3F1360D3FE3E49DE" modified="2023-02-22" version="1">MSKKERLKFAYDQFKTNIKEYAMLLAMFLGMFARGTIESLISYLMTLSRDYRYIAYILQEEKRIHKELFNASMDVDEHVSKVTRHQQRAMIREKLQEKYGKSGFLKDEGIRKLHQYVEETEEREDSEAFDAPLPEIVTEVIKEELEAEKVIEEEQAIKEEEALKDSEAEAKALKEEEGDVVVSDSEVESRKSVVGLLGRKKESIASKMSKDSILSKGSSKTSKESILTKTSVESKEVAVITPAIIVQHDSEDDTTTVVHVPQAIVEIPRGSSTPSQAEFRKIVDEAERQLSPPITKPTKEEYLFVRLIIAFYYAILSRSELICYIMIILNHIHSASFLSMPLPFMMLLWGTLNVPLPTKQFWITVITYTEAMVIIKYVFQFGFFPWNSSAPSLDPFWLPRILGIEKNPHYAMWDLVLLMTLFLHRNILMATGLWKNTEKHKSEDDSISSDESEKDEISKASNASLQLSPPIVPKERKGSLFSRRRLTQISFSSVTNKFRRERIKRKWVSFNGFDKSLLPTNNPNNPYNPHHVRFSFINDFDVIVRLPSTDSDSSVTHKVTKVRGFFGILLHPVNRVPIDMYAPMFLCDIICFLIVIFGYSDFGTDQGGGSVAAYFEENKVPGTLVAMLIIQFVLIVTDRALFLRKFLFGKLCFQLLLVIFIHIWIFFLLPAATDRLFCWKCFDPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y276</accession>
    <name>A0A914Y276_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glutaminyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y276"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1428.t1">
        <property type="protein sequence ID" value="PSU_v2.g1428.t1"/>
        <property type="gene ID" value="PSU_v2.g1428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000003">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="9">
        <location>
            <begin position="72"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="10">
        <location>
            <begin position="188"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1428.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32285" checksum="3465A9B08BAC947F" modified="2023-02-22" version="1">MSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2J0</accession>
    <name>A0A914Y2J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13454.t1">
        <property type="protein sequence ID" value="PSU_v2.g13454.t1"/>
        <property type="gene ID" value="PSU_v2.g13454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13454.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12947" checksum="A144703152EFAD7F" modified="2023-02-22" version="1">MVKLKTIQAEYVKEFIEQRKKVAAARKKRVDELDRLIQSLAPKLKEEYARGIKRTFKDYDNKMKMYDFLQLATPKDQPAAAVTQITVNLKPPRAPRREEILFSVDGTPIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2Q5</accession>
    <name>A0A914Y2Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2Q5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12063.t1">
        <property type="protein sequence ID" value="PSU_v2.g12063.t1"/>
        <property type="gene ID" value="PSU_v2.g12063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042983">
        <property type="entry name" value="PKDCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46448">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46448:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12063.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21607" checksum="C8D4262AECA63B15" modified="2023-02-22" version="1">MDCMDIADGDLNKEYQCVETAAKSFITEIGFLIKLQNDPNVPKLFAYCIPFDFIAHAELLASATVSGKPLDIIHLTTSDWSERVRILDEIIRFLTRSRPLLFRDFRRQQFVLIKNQPSMVDFDDVISTNNLTDHEPIVQKLYISFIDQILFATSPLKAQKSLAAIKEAYSNSTLTFENLSKITKKLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2X9</accession>
    <name>A0A914Y2X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2X9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13802.t1">
        <property type="protein sequence ID" value="PSU_v2.g13802.t1"/>
        <property type="gene ID" value="PSU_v2.g13802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13802.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="23000" checksum="0D5712A6972ED510" modified="2023-02-22" version="1">MHSMVNPCIAILAQELDLLKYVFRGSYKLLDRNRKLFFDFFNHQIEEHEKELDLDSLEEPTDFVEAYLREMYLAEKNGNQTFFTKKQLANMCLDLWFAGMETTANTLEFTVLYLIRNPTVKKKVQEELDQVIGTSRLITLKDKCNLPYLQATINESQRMANLLPLNLLHKTTRDVTIHGHFIPKNTCIVPQIGNIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3D7</accession>
    <name>A0A914Y3D7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">F-ATPase gamma subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3D7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13961.t1">
        <property type="protein sequence ID" value="PSU_v2.g13961.t1"/>
        <property type="gene ID" value="PSU_v2.g13961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000013">
        <property type="entry name" value="ATP synthase subunit gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13961.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="33720" checksum="49516C34BE209CA3" modified="2023-02-22" version="1">MLSQSVNRVSLAAASAILEQQRGMATLKDISIRLKSVKNIQKITKSMKMVAAAKYAKAERDLKGARAYGVGAQTFYDNIGSSDTSATEGATAAASPKEGGKKHLLVLMTSDRGLCGAVHSSIAKEAKNILKNKPDDIEYKIVCIGDKSKAALQRFYPKDLLFTANDIGRQPPTFEDASIAANEILNSGYEYDEGYIIYNKFKTVVSYQTTKLPLMSLEHIKSNDKLLLYDSVDDGLLQSYTEYSLAQLIYYAMKESATSEQSSRMTAMDGASKNAGEMIDKLTLQFNRTRQAVITRELIEIISGAACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y583</accession>
    <name>A0A914Y583_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome-b5 reductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y583"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14399.t1">
        <property type="protein sequence ID" value="PSU_v2.g14399.t1"/>
        <property type="gene ID" value="PSU_v2.g14399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein pyridine nucleotide cytochrome reductase-like FAD-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14399.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14862" checksum="302E5CC448ACC796" modified="2023-02-22" version="1">MFRFYSPISKPEEKGYFEIIMKIYSPSSENPNQGIFSTYMDSLPLNSEITISGPFGRFGYLSNGDFLVNAKAVMKYTSIAMISGGSGLTPMLPIIREVFKENNINGPKISLIYTNKTEDDVIQRFEFIYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5N0</accession>
    <name>A0A914Y5N0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5N0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14548.t1">
        <property type="protein sequence ID" value="PSU_v2.g14548.t1"/>
        <property type="gene ID" value="PSU_v2.g14548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14548.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19074" checksum="F3930DFB48E51E9F" modified="2023-02-22" version="1">MLELRNLRTITSEAFKYVSSPFLSGVDLSGCTQLTSEGIFYLVHQNPSIRCLYLNHCRNLDDQALYDIAQCIGENLHILELDFLPNMTDPARTLHQLSQRCPKISQLSLCNFFDSTESAEDEEIPEYRIEGQSLDYVDLCGNYFTTLPELPQSVRTIRLSVSGSEDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6Q9</accession>
    <name>A0A914Y6Q9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6Q9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1589.t1">
        <property type="protein sequence ID" value="PSU_v2.g1589.t1"/>
        <property type="gene ID" value="PSU_v2.g1589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1589.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16698" checksum="F64B0777AD516B9D" modified="2023-02-22" version="1">MNKMVQLYELSHKLIEMEPERESTYYAIGCYYYIAEQYGAARKFFHKSVSINPNFGYGWLAHGHALSFDKEHEQAMNCYLRASRLLENCAEPRLYTGIEYCNANNLKQAAQNIKSAAAFCETPNAVILHELGTVYLYDKDYDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7T3</accession>
    <name>A0A914Y7T3_9BILA</name>
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        <submittedName>
            <fullName evidence="4">CW-type domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
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    </reference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG09882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995">
        <property type="entry name" value="PROTEIN CBG18546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
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    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15335.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16837" checksum="46A6BCAD7131D381" modified="2023-02-22" version="1">MLPASTITSLTANSTVQCSKYNFVRKGDVGKDSSDDDDEDDDSSSSSVEIKEIEKLKGQRDKIMKKIEDHKRHLKRIRRQASAATDMGVDATVVGRRFKLSCDTKGVATDGSGLLTLCSRCWAWRELPENYYPRYMNELICDDTDGSCLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8D3</accession>
    <name>A0A914Y8D3_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g15532"/>
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    </dbReference>
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        <location>
            <begin position="64"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15532.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19200" checksum="368F878336D61497" modified="2023-02-22" version="1">MLKSLRQSYSALNSLSFFDASLLSDDLIVKKSDNELVWQQISMQNKAVSKEVKKTLKLFGDVLKVPEENTSDDSEMEEEDDDVEMEDEEFDEDIEEEDEPPRKKKKGVDLFNIRPQDLKNLDSKLKALDNDDEDDEDDEAEDEEMDDDSKNLIGLVSDETNIKYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8R8</accession>
    <name>A0A914Y8R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g16587"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16587.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23440" checksum="DD71DE97B16F679B" modified="2023-02-22" version="1">MESGKAVSEGDKVSEAEEACEFENASMSNHNGDEENEGVEEEKEMHNYYPGHYITSEFEQFFQRLALEPNNEIDLDVMYRVMCGRNVCDKKLTYICDFIEYQYMYIELENPLLTNLDHFDKVSDAAVIDGWTGYWMHDIAHAFNVSVVYTKISDPVGIVILSTLIALELFHRYPGRSVMRGRCIYVTGEALNFFRTVCCRTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8S2</accession>
    <name>A0A914Y8S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8S2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1567.t1">
        <property type="protein sequence ID" value="PSU_v2.g1567.t1"/>
        <property type="gene ID" value="PSU_v2.g1567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="59"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1567.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38158" checksum="766AD749F9244E85" modified="2023-02-22" version="1">MDKAAELKNLSDQLVKNIQTEQSKQYLEWLQKWDCFLVNHMSNQTLSSNSELKTLVRQGIPHTYRSRVWKSLVQIIVANAQSEFGKNYYSCLLGRNSERLKNPASDPCLRQIDLDLLRTLPTNIHFINADSEKMNQLKRVLYSFRFHNKTVGYCQGMNRIVAVALLYLKEDDAFWFLVAVVEYLQPPEYYTPTLKGAVIDQKVLTDIVQEKVPKVWNHLKQLGVDLSIFTLPWFLTIFVDSVNQNLYLHIFDVFLLEGNKVIFRFAIALLKIIEPKLLECHTIGAIQSCLSNLSDLKLEAKELAKVAFGIHSFSIKTIESRRQMYANSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9X4</accession>
    <name>A0A914Y9X4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9X4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17015.t1">
        <property type="protein sequence ID" value="PSU_v2.g17015.t1"/>
        <property type="gene ID" value="PSU_v2.g17015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17015.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24943" checksum="8A49833F34AC3E17" modified="2023-02-22" version="1">MQHPKNFGTHEIHIDDLIAKNKDIDPFLIRKWERIFTLSFDRNASHEIEWSDFYVCLRKIREIYGAESKQMGYARKTLEALWEGLQRLADSDGDELVTIEEWIQVLKKVDSKKGDVPKWFSDYKKFMFKLFNVSEDGHLDINEYADGMSVYGHELHEAHDAFHKFAVDKKGEPKSHITYDEWKELFIDLFFSADKKKLGNHLFGILDVEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA62</accession>
    <name>A0A914YA62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA62"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17095.t1">
        <property type="protein sequence ID" value="PSU_v2.g17095.t1"/>
        <property type="gene ID" value="PSU_v2.g17095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038046656" evidence="1">
        <location>
            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="138"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="323"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="385"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17095.t1"/>
        </source>
    </evidence>
    <sequence length="484" mass="55313" checksum="2CD4707B9FED1BAD" modified="2023-02-22" version="1">MRNFKEGIALLFLFLGISAALKLDNSLLKDDENSTFVSRTLRSQNFDNNFDGGYRNDAFRFVSIGFYCKRRQSHTFALGPCSSLFVQCSNDGNYEFQECPLEQIFDGQICVPAFKIRECLDSRINALNLATEKLASATEACNNGPGIQISTSKDQCSRQALLCDSFREPRAISCPIGQILDSATLQCLPSSTCQWAPSLIKDNLLRDYCKYRPISTPSYYPLTNGNDQTSSRCQNWFVSCRDKEFIFCDAGKIFDKASSGCRPPLPQERCPTSDICRGWEWRAIPLGECNPQFRYCEGLKSRIFTCREDHVFQDKACIPSKSARGCPECKQGETKPTKNCRQFFECQTSYGSQLWTLKTCPSNNFYNRESRRCELIRGNACADFQQTCRDGDSYNPSCGDYLLCREGEFHPGKCPHLTRWNKQTLQCIPDNTCRRYDNSNECRHGDIIPTVDCQTYFLCDKGQFVKRPCKESLYGKNRKQFFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBJ8</accession>
    <name>A0A914YBJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17575.t1">
        <property type="protein sequence ID" value="PSU_v2.g17575.t1"/>
        <property type="gene ID" value="PSU_v2.g17575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17575.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12088" checksum="F5073AEDF077BFD5" modified="2023-02-22" version="1">MTDFAQGETVCKTSVINLLIHKKKGFTIGQVVATQKFAYKNPTFKWNAQTNKAVHFQANLLNRKVISDFPPHAEIHVSYKNRTIHHFAFTQFIRTTNTTYDRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBQ1</accession>
    <name>A0A914YBQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBQ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1763.t1">
        <property type="protein sequence ID" value="PSU_v2.g1763.t1"/>
        <property type="gene ID" value="PSU_v2.g1763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1763.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10574" checksum="C40549B9FDCEA934" modified="2023-02-22" version="1">MFVTDVSIQLIDKTDKEKGYDWSARQKLPWFKNSYLIAGTVSFVAIASLLSHLYVIQYFISTKNTSTPIFAANQKRKTTPKNVYSFLQLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCH1</accession>
    <name>A0A914YCH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCH1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16453.t1">
        <property type="protein sequence ID" value="PSU_v2.g16453.t1"/>
        <property type="gene ID" value="PSU_v2.g16453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16453.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9361" checksum="E0A28ED738FF040A" modified="2023-02-22" version="1">MTTEEIVEQCLLFLLAGFDTTANTLAISTWLLTKHPDVQQQLIDELDDICTTDEITYEQINELRLCDAVMKEALRLYPIATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCJ6</accession>
    <name>A0A914YCJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCJ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15195.t1">
        <property type="protein sequence ID" value="PSU_v2.g15195.t1"/>
        <property type="gene ID" value="PSU_v2.g15195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15195.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14386" checksum="6632722CA61C47A9" modified="2023-02-22" version="1">MTTRVKDGTKCFRCNKQGCRKEKGFFIDTFFEGSHLSCKEIFQLAYFWSQNLTAQEFLQFQMKRNDGTVISTRTIVDWKQFLRDICVEHLARNPVMLGGPGTIVEIDETVISRRKYNRAWYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDJ1</accession>
    <name>A0A914YDJ1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YDJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17364.t1">
        <property type="protein sequence ID" value="PSU_v2.g17364.t1"/>
        <property type="gene ID" value="PSU_v2.g17364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19854">
        <property type="entry name" value="DSRM_DHX9_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19855">
        <property type="entry name" value="DSRM_DHX9_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000028">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044445">
        <property type="entry name" value="DHX9_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044446">
        <property type="entry name" value="DHX9_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF119">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="174"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="392"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="640"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1178"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1190"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1217"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1237"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1262"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17364.t1"/>
        </source>
    </evidence>
    <sequence length="1275" mass="142180" checksum="2B9B6545149AA3FA" modified="2023-02-22" version="1">MAEDIKTTLYAFLGRKKLGCPEYNVNEERRGKGIVKYKCELRVPNMNYVGIGCSSSKKNAMSNAARDFGMYLIRESLCTVSDLPNLLEGDLEGAAPPNTTFMNGPPLTSLDVKQPYHTMPPSSAPYGAVNVPRIPTYRPKTEHDQYVDQKAAEVAQSENVDMGAEIHGGWVMENCKKGLNEYCQKHKMPVPNYVMRQTSTIGNNYNFVAEYSIYVAALNKTIHGRGEGSTKKVAESSCALTVIRQLYHYQIIPSSTEKVQKKEASNLPEIPVILDQSLVERIDVYLKNVGVEPTYDVLESSKENPMSLIVDRKLAVFEDSDPSSGYTIGWAPPMINWNAWRQTNIDDQSFGMKPLEQISVDLKAAEDTIRIPDYVKSVREKLPVYKIKNDIVNAVKNNPVTLIKGATGCGKSTQVCQYLLEEFIHSGKGAYFNAFCSQPRRISAITLAERVAEERGEQLGNSVGFAVRFEAISPRPYGGVMFVTVGVLVRMMESGMRGISHVIIDEIHERDINTDFLLIIIKEMVAKNPQLRVILMSATIDTQLFTDYFGKCEIIEIAEHANEVQFFFLEDAIKFLQYMPPIPDEKKKKKRARSPPPEDEDTGTLDNSKTTFENIDTASYGHATAEALKRMNENEIPLDLIEALLVDVHDKGAVGAVLIFLPGWNIISMMLSRLENHPIFGNKEQCLVLPLHSQLTGKEQHRVFEEVPPGVRKIILSTNIAETSVTINDVVFVIDSCRAREKIYSFRNNIIHFATVWASKTSIIQRRGRAGRVQKGFCFHLCTKKRFELLEEHRTPEMLKTPLHEIALTIKLLRLGNIYEFLERAIQQPPVDNIIEAEVVLKEISALDNNNELTELGKILARMPISPVIGKVIILGAALGVGDLMCTLAAASSFNTPYVQMDRKFTKLSHRHRSFAGRYLSDHVALVTANQRFRDQINYGENAAKGYCTQNWLNYTCLVMSNEARKQIRDVLVNKGFPEAAFYEFNTDPNTDDPFLSLFLSLAVQACYPNVAYLRDKRKVYTLEQATALLSKMSVCVPFEPTQPMEYPSPLFVFTEKMRTSIIACQQISAITPIQLLLFGSKSVEAEGHERVMLDSMIPLKMDATVAAKLVALRPCIEACVVNACKNPESLASPTQNDTELIQLLKDLSMENAGKNEAPPSRSNAAQPQRPAFRAYASRGHPRHSGYGNRPRPYVSPPYRGGGGGYGGNSNFEPRGYRGGSGGGGYGNRGGGGGYQQAYTPGMSQMNMNSNPSYNFTDDSPLPVPPMPPFSREPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDT6</accession>
    <name>A0A914YDT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDT6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18392.t1">
        <property type="protein sequence ID" value="PSU_v2.g18392.t1"/>
        <property type="gene ID" value="PSU_v2.g18392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000011">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="30"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18392.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="47480" checksum="FEE02FDA2F38A71A" modified="2023-02-22" version="1">MDQFLNQWQTFRQHCESYESLNKYCRSGALRDSVFRSIAWRILLGSLPFNKDLWMQKAKQNRDNYKTWKEKIPANPREEVFDMDLGLNNPLSLHSGSPWQKFFEEQEIKDIIGKDVNRTFPEVNFFASDNVRQILSDILFIYAKRNPKISYRQGMHEILAPLLFVLHADRQSIDHFTELQIETDINNTDLQLLKTLNDPRYIEHDAYDLFSKAMNIVEGFYNVADENFADESVASPLPASPFSLFVSKKVEIVKRKLSFRNATTKPKAPWISKLELIYDHKLRSIDFALWSHLNALDISPRLFGLRWLRLLYGREFPFPDLLFLWDVIFTDRPMFTIIEDIFVAMLIQIRSLLLNADYSTAMQYLMRYPPISDVQAFIQYCLHLHSPKVLLISLCHSGHVNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFR3</accession>
    <name>A0A914YFR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosinase copper-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17599.t1">
        <property type="protein sequence ID" value="PSU_v2.g17599.t1"/>
        <property type="gene ID" value="PSU_v2.g17599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17599.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24475" checksum="19D00AA747B49D2B" modified="2023-02-22" version="1">MICNELQMWDQNARQFIDEQQQMEANTVINAPAVPQQPWLSPAVPQPFNPSPYACMDLGCVCSYMRGLAGPGGQCVLNNGQPLRPAYRKEYRQMSDNERQRFHSVLQQLKRNGEYDRLSEQHRQVGTASGAHSGPGFLPWHREYLKRFEIAIRMIDPGLAIPYWDSVLDFYLPDPRDSILWSPLFVGETDFNGNVVNGPFAGWRTLEGRAFITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI78</accession>
    <name>A0A914YI78_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="function">
        <text evidence="13">In parasitic nematodes PEPCK carboxylates phosphoenolpyruvate to oxaloacetate thus introducing the products of glycolysis to mitochondrial metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YI78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20039.t1">
        <property type="protein sequence ID" value="PSU_v2.g20039.t1"/>
        <property type="gene ID" value="PSU_v2.g20039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF16">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="16">
        <location>
            <begin position="62"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="15">
        <location>
            <begin position="293"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20039.t1"/>
        </source>
    </evidence>
    <sequence length="639" mass="71646" checksum="FEF9577B94ECAC48" modified="2023-02-22" version="1">MTTNPNLLTPFKATKADVESSSLRQISEDAFYVINEVVTRRLGHIPILKGDLHDLPYKVQRFVAEKAELMRPRGIFICDGSQHEAEQIISKLIERGMLTPLAAYENNYLCRTDPKDVARVESKTWMVTPDKYQTVTHTAPGAEPIMGHWMSPFEFGGELDSRFPGCMAGRIMYVIPFSMGPLGSPLSKIGIQLTDSNYVVLSMRIMTRVNPDVWEVLGNNDFVRCIHSVGLPRPVKQRVINHWPCNPERVLIAHRPSEREIWSFGSGYGGNSLLGKKCFALRIASNIAHDEGWLAEHMLIMGVTRPNGKEHFIAAAFPSACGKTNLAMLEPTLPGWKVRCVGDDIAWMKFGEDGRLYAINPEAGFFGVAPGTSNKTNPMAVGTFQKNSIFTNVAETSEGRYYWEGLEDEIKDKNVEITDWLGNPWKLGDATPAAHPNSRFAAPAKQCPIIHPDWESPEGVPIEAIIFGGRRPDGVPLVFETFGWHHGIFTGACLKSETTAAAEHKGKNVMHDPMAMRPFMGYNFGKYLDHWISLEKAPHKVPKIYHVNWFRKSKEGKFLWPGFGDNIRDTAVGVIPSQGSINLDGLGDINWDELMSLPADYWKQDAKEVRKFLEDQVGSDLPNEIREELESQEKRIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKC5</accession>
    <name>A0A914YKC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsA</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17761.t1">
        <property type="protein sequence ID" value="PSU_v2.g17761.t1"/>
        <property type="gene ID" value="PSU_v2.g17761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24048">
        <property type="entry name" value="ASKHA_NBD_FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000030">
        <property type="entry name" value="Cell division protein FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050696">
        <property type="entry name" value="FtsA/MreB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007009">
        <property type="entry name" value="PRK09472.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32432:SF4">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32432">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14450">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17761.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="27391" checksum="08B8F7C3672B2A3A" modified="2023-02-22" version="1">MAKNIVKAVERCGLKVDQLIFAGLASSYSVLTEDERELGVCVVDIGGGTMDIAVYTGGALRHTKVIPYAGNVVTSDIAYAFGTPPSDAEAIKVRHGCALGSIVGKDESVEVPSVGGRPPRSLQRQTLAEVIEPRYTELLNLVNEEILQLQEKLRQQGVKHHLAAGIVLTGGAAQIEGLAACAQRVFHTQVRIGAPLNITGLTDYAQEPYYSTAVGLLHYGKESHLNGEAEVEKRVTASVGSWIKRLNSWLRKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL03</accession>
    <name>A0A914YL03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL03"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2103.t1">
        <property type="protein sequence ID" value="PSU_v2.g2103.t1"/>
        <property type="gene ID" value="PSU_v2.g2103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2103.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20740" checksum="05DFBE7F91289A61" modified="2023-02-22" version="1">MAGGAVSRTLIRAGGFRVFPKSLNELDIRAIDGNMLLLQCPDIETNETIIWTINGEQFTRKQATWRRYLVGNDLALFPADSTEDYGIFECYAGEEIIGQGTLFVETQIHAIGEGFVHYCLVGCGVLLTQIIGLILYLLYLNYIAKAAEKDNEEVANEQNDEEEEFISEAENDDDEQTEEFQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMN8</accession>
    <name>A0A914YMN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMN8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20851.t1">
        <property type="protein sequence ID" value="PSU_v2.g20851.t1"/>
        <property type="gene ID" value="PSU_v2.g20851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20851.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="12096" checksum="2AF8D124241ECE70" modified="2023-02-22" version="1">MSPTLSSTRRIKFLFYLNDKKPELLIDQISSDMSSHEEEKFWNEVLNGWDTTEDKYENRLLEKIRRRLHHLKSTASSSTDSVPSILQSNEETQKVEVRRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNQ4</accession>
    <name>A0A914YNQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNQ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21050.t1">
        <property type="protein sequence ID" value="PSU_v2.g21050.t1"/>
        <property type="gene ID" value="PSU_v2.g21050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21050.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="19754" checksum="C051EAE17B7F3834" modified="2023-02-22" version="1">MAELAGGLYLRQPDRLADDGAGTTLCAFHSRQHAGQPFARTGGPEAQASLLRKIHLDGTGGPVGQRHPCRAGLVWRWHGAGQFTGRPLCGPLPGSQHSPGSDLGYRRALAVHDHGPPSNPWSLEHHADWHPGGLGPRLQIRLMDVAGDAQTLAAALNHSAFNMANALGAWCLAGLGWPGLAHHFAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPB3</accession>
    <name>A0A914YPB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20833.t1">
        <property type="protein sequence ID" value="PSU_v2.g20833.t1"/>
        <property type="gene ID" value="PSU_v2.g20833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20833.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18501" checksum="5897DF8D7D62808C" modified="2023-02-22" version="1">MLHAVNDMPGTALIYNSVEPDSSPETIQMLADELKFVSKQELVKLLDKHNAPAPPPKVHVAVNMLDGGASTSQFSSSTPNRSSFFNTIPAEISLSKSLISPERNLAEILSSERQKLDDEYNEKFQRIEDRTKEVELKFKEARTEDSRLKEWKNKLEEERKQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPI9</accession>
    <name>A0A914YPI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21546.t1">
        <property type="protein sequence ID" value="PSU_v2.g21546.t1"/>
        <property type="gene ID" value="PSU_v2.g21546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21546.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19399" checksum="D19D2E8B11CB548F" modified="2023-02-22" version="1">MGSRGINERFIRQCGRSFACTSKLACCTCASHECKIDADCDQIIGLTCVAGRCQPKSDNQLLLLHKSFADNTTVKAHFCDTDKDCFDEAHCRDNKCTHNLVRKRETCVPLKPMDCLCVCVEFPELFKPCQMMLPKCNVDEDCALNSFCFDDQSENGQRRCSPLIARPTNNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPS7</accession>
    <name>A0A914YPS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPS7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2823.t1">
        <property type="protein sequence ID" value="PSU_v2.g2823.t1"/>
        <property type="gene ID" value="PSU_v2.g2823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2823.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10723" checksum="83AD62C74E4E0253" modified="2023-02-22" version="1">MTGLLGIVITFFTFMFPFEMIIVQKNAGILNNDGKNVIQQLGCYDNIDKKMLNKNVIFELKSNAPKICLIFLPENVVVNYKMINFSSEKNLNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ27</accession>
    <name>A0A914YQ27_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MADD family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g1947.t1">
        <property type="protein sequence ID" value="PSU_v2.g1947.t1"/>
        <property type="gene ID" value="PSU_v2.g1947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000010">
        <property type="entry name" value="Protein CBR-AEX-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056574">
        <property type="entry name" value="Death_MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039980">
        <property type="entry name" value="MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057469">
        <property type="entry name" value="PH_MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008:SF7">
        <property type="entry name" value="MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008">
        <property type="entry name" value="MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23629">
        <property type="entry name" value="Death_MADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25328">
        <property type="entry name" value="PH_MADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="11">
        <location>
            <begin position="32"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="952"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1947.t1"/>
        </source>
    </evidence>
    <sequence length="1500" mass="167398" checksum="0F0842FFC3B7DEDB" modified="2023-02-22" version="1">MDDKGKELCPRLIDFLVIVSRRSPLKLKSNGTHAPIKAYTRNRDELSNPELLRRYPTDDHRDFRLPTDVTFFCQPEGCITVTSHRRLKAFHDTTSFVFTLTDKDSGKVRYGITLNFFLNNEKKKRDEKSVNKKKGLTASLTSLCLMSHHPFLSAYRDILTLLRQLIDACNHRCNQNDKLPRNSVWSVLIGHWDGDIPDTVMEEIRQIETWILMLLSSPVPVPGKTKVVLEVLPLEIMPMIEFALPDHTRFTLVDFPLHLPIELLGVDVVIQLLAAVMLEYKVVLQSRNYNAVSMCVMALVALMYPLEYMFPVIPLLPVHMPSAEQLLLAPTPFIIGLPASFFIVKKISAPPDVILVDLDTNEMTCGDGLESLPDFPEPELGNLKNAFRKALGKMTAQPPIMQQDGHRGSFESSYTIDGDEIDVAVRVAMIKFFNSPNIFANFSEHCRTLRLYPRPVVALQADSFLRSRPHQSPLIQELCKTQSVEYFAECSLCPRNETYVRVQTGITTASQIGDKAKWFTDQLMPIHFNAYPDSSTLTEALHKMKTDKFGDHSDSEDDDISDLEVGSHSDEPAIESTITEFNPNFEAAKPLSEVNDIYRAPKKLEFPQSESALSIDSSLSSGRSSPASSISASAADSEADFARLAENLALKSDSRGEFTFDHHGDEPNDSESTPVQGRRGIIVTSKVLQQNAQNQANTPLKTPPAKSAAMKGFHTIADSSEKVFGPQLMNALNGYAEKSHGMLSSVLNKTAPKAQALRDKTMRPLAEAAANRMEHGQNLINKKNSEKIASNSTATATQQNKNQQIIREVCDQIQAGQGIGVFTYPKVKRLLEDESLRELVCSKLNIGIDLHYAEDDFLVDRQLTKAQYKGYIKILQACILGLEHCYNTPGSNGLASMFHVLEIAHSHYWAENDATTPGSGISSVSGTPSASIQNIAQHVVQNETPTVKLPATQMDSRQIPGGPVTTSSPSSSSVSQPSSSTAPPLGLPPPPPLPPRASANTSNGAPTLPPPPLPPRPPASAVIEKKLLMPKNHGNGFHEDDLVTPKVDDHIKRPLLLTSTMTEADITHAPSATQSPPNKQIITKPDSLPVATLSLPPQPNNLQNHDVIKHYLFRDLIANNPNPLWQQMIFWENAFFDMVAQERDIIGMDQEPSEMIDRYSGLSESEKKRLELEEDRILATLLHNMTAYMVMCGAQTKIIQQKVRRLLGKAHIGLVYSKKINQLLDELPKAQSNNIPLKPLGSRLMQKQSFTVHTGASSEGIMMFLEVTDDAIILRAVTGAIAERWWYERLVNMTYSPKTRVLCLWRRQDDQVYMHKFYTKKCRTLYNCLKSAMERAAARGKVNIAGRDLGGEFPIHDTETNEGGLLQVRMDGVSLLFANRQEFVELRNIKKCNTYGGNMFVLEEYRRDKDELIQRRYISKMAVEIAWKLHRIFSIQAALVEEAEEELNIDTTSIKSDSTDAASTDLPRFHIDLQKSHLILEKTGYPSESRVRLCSNSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQG8</accession>
    <name>A0A914YQG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQG8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21291.t1">
        <property type="protein sequence ID" value="PSU_v2.g21291.t1"/>
        <property type="gene ID" value="PSU_v2.g21291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21291.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18027" checksum="20F00462AD186E50" modified="2023-02-22" version="1">MDVYVADITCSLLGLDFCDDFAVSFRIAQISTPTAAAKSNVSVKTTSQPANVSDNVSSAIFQSYIDEIQKEFASLFQPGLGRCTKAHIHLQLKPNARRVHVKARRMNQPAMEVAKAEIDRLCSMNVMEEQKGGFAEYATPGSIVKRKDGRSRFVVDYSTGRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQH7</accession>
    <name>A0A914YQH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQH7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21304.t1">
        <property type="protein sequence ID" value="PSU_v2.g21304.t1"/>
        <property type="gene ID" value="PSU_v2.g21304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037754957" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21304.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15676" checksum="8E058B71AA58C332" modified="2023-02-22" version="1">MVYFFCFFLLFIEFTIVENKGSGHSGHSGHSGHVVHGSSRFKHVGENVQQRLSSLKGKLQDVIASIKEKAAGSEQTPQTIKKTVSDIIGSFRNPSPEKNDNKNVTIIGEIVGKTIASSNISDVSLKKTIRIIRTRNVLFFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQZ9</accession>
    <name>A0A914YQZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21505.t1">
        <property type="protein sequence ID" value="PSU_v2.g21505.t1"/>
        <property type="gene ID" value="PSU_v2.g21505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21505.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11139" checksum="2DA04F02772D0BB9" modified="2023-02-22" version="1">MFLRAGISAEPYSKAMENLTLIKSDYFEKLHEISMEYMLEMFNPFSRILLDTSKTKWIEHLKSELEEDKPDYRMILESFVVIVLGSLNAMVIDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRD2</accession>
    <name>A0A914YRD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF304 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRD2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2737.t1">
        <property type="protein sequence ID" value="PSU_v2.g2737.t1"/>
        <property type="gene ID" value="PSU_v2.g2737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2737.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21990" checksum="66483DD40709A068" modified="2023-02-22" version="1">MEPTILPKIPPSYEGVISGSVPSSPIRHQSFSIPSSPPPTYSGREAKPYHTHLRWNLLFTFLILLFISSAFWIPFIPKVQKASMEIVVIIIGILHLLWFMAVFNNFRYLWRLRRYKHHQIDLQKLNNSGKIVKHLVGITLYKEPIELMINTLDSIANQADAKKKICAFVGMEQKTPDKEEVSFGGFLKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRD6</accession>
    <name>A0A914YRD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19942.t1">
        <property type="protein sequence ID" value="PSU_v2.g19942.t1"/>
        <property type="gene ID" value="PSU_v2.g19942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06587">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19942.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11657" checksum="12FDDBC0484DA7D3" modified="2023-02-22" version="1">MFDPDGNYNEFYCDTIKDWRSVLGGPMELLTSRWDPEGQEPFTEGRYDSDPVLETVADAPVQPRRVTHAVLRTAQLDAMRRFYTEVGGLEVVYENEQPDPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRY3</accession>
    <name>A0A914YRY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRY3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3506.t1">
        <property type="protein sequence ID" value="PSU_v2.g3506.t1"/>
        <property type="gene ID" value="PSU_v2.g3506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3506.t1"/>
        </source>
    </evidence>
    <sequence length="607" mass="69234" checksum="FC027786AEB254C7" modified="2023-02-22" version="1">MKEPFPLQPNNSTLRALFKSCHYGLLNPQSLNHNLKGNSTLIKKLQLSDILRGHEGCVNTIEWNSEGKLLVSGSDDRHIIVWNAAGKELSKFPTQHDGNIFAAKFMNECNDSKIVTGAADGKVFVYQWRGNSTIEKIREWKEQSRRVKQVVLNPGNPNTFYSCSENGFIVQYDDRADINSIVQEEQHGVKSIAVNPVNYNYLAAGVSEEGIKLYDIRHTIKPVLTFASAITTTKAESHTATYIEFNSTGTKLLANCQAEGIYVFDAVPGSEKEPRYLERMEKILKSTLSNDDKDPEHFISEWSPYDAEKIEAKEYYLVENYVKAIEAYSRVIYKVENILRLDPTNINFKADLATLYQARGDCFLKRDYKCDVMDAARDYIRSMELFPKNYRAHVGICGALEGMQQYAKAKKWNTAFVERFNYSGESILKHPEKKSLSKRWNTLKMDGLRDYHSRYVGALNQRTDIKQARFLGGNDEFIVSGSDDGHMLIWDSLTGNIVKLLKADNKILNCVTPHPTAPLIASSGIENVIKFWTPFENSNELSHKLLPEDSDIWQRRDDTSEMDEIVSQGQLNQLESNHMYINNVEIFLRIAQLRNNRPEAFEGCRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSV8</accession>
    <name>A0A914YSV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3249.t1">
        <property type="protein sequence ID" value="PSU_v2.g3249.t1"/>
        <property type="gene ID" value="PSU_v2.g3249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="117"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3249.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40455" checksum="71351FBF5C428100" modified="2023-02-22" version="1">MRSEIFVGVVRLLLACAGSYFAVRLMIRAMDPNKEQKEKSKKKAEELMKIIELPEDIELDEYEMRIAAMLVPESNGIDWSDIGGLYKVIEDIRGALLLPLQMMHMKQTPLVSSLLSPSKGVLLFGPPGCGKTMIAKAIAKSIHARFIHLDISVLTDKWYGESQKLVSALFSFAEKVQPCVIFIDEIDGFLRNRSDLDNETTALIKTQFMALWDGFASGNNEIIIMGATNNPLSLDPAIFRRMPARFEVPYPDEKSRAKIFEIYLKSEKCPDVNYPQLAKFSPRLSGSDIKEVCRAAALSALNRAYNGNSSLHEADFNIFQSDLLRSLNVCYGGKFPSCVSEHVNDTVNEMFDGKITYESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTM5</accession>
    <name>A0A914YTM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3507.t1">
        <property type="protein sequence ID" value="PSU_v2.g3507.t1"/>
        <property type="gene ID" value="PSU_v2.g3507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3507.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27949" checksum="4CACA3A5E68AFC43" modified="2023-02-22" version="1">MHFYHISDDTRDVQTFQIPEQNIYTKSIRLELLTHYGKEHYCTLSSFRVYGISMVDEYEAEAAAFGVTENAGAPMKITVSETISIDLPVKEPLIISPEVTEPPLETTLEIPPINIIPEPILPLAPWQIRDCLKCDNNHPKAVTAWLCYVFSPSICSKRNIKNWKNGTIILSKGQTTFLKAVLQPRLLCPLFNVSTEKKVEEKPTVLLSSTKHESIIMHTLETEVKKQSIVQHKRMLKNCYAHFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTP2</accession>
    <name>A0A914YTP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTP2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4045.t1">
        <property type="protein sequence ID" value="PSU_v2.g4045.t1"/>
        <property type="gene ID" value="PSU_v2.g4045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4045.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35062" checksum="35C35EE86C8E7397" modified="2023-02-22" version="1">MVCCQNTLNTVAYFTLTYIGYRISRGIYNIVYPYLLASPRNLHKLAGEATWAVVTGSTDGIGKEYAFELARKGFNILLISRTQTKLDSVKEEILKECKNIEVETIAYNFTNASLDDYKNKIISIIEKKDVGILVNNVGLASSNPEMLHKADMQESADIVVINMLPVTILTSAILPQMVKRNSGIIVNISSGASHLTVPQLAVYSSSKVYINHFCNTLRNGYAKSGITIQTLYPAYVSTNLSQVKVSLFALHPKAYAQSAIKTIGISEDTTGCIQHQIQAVVYSLPQQFMTYFAQKTLEKKQILLKLEREKAEKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTW8</accession>
    <name>A0A914YTW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal lipase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTW8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3107.t1">
        <property type="protein sequence ID" value="PSU_v2.g3107.t1"/>
        <property type="gene ID" value="PSU_v2.g3107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF8">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036778886" evidence="1">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="88"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3107.t1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33615" checksum="5213477C14A7F99A" modified="2023-02-22" version="1">MHKFSKIALFLTAFVLAIVYGQYSDEFARRKMWPMIAMSSTNSTRCLQECLNKYEFRRNVVVGCDLEQNGPDTCAGSALVNHDDKAIVLTFRGSVGSHQVTEENGSLGDKVDFPGGGRVSHYFYNAFLQVWNGGVKDDYLTYKNKYPDYEVWITGHSLGGVMASLGASHVSQMKFADPNKMKLMNFAGPHGGDQAWADRMPTLVPWAYRVVHRYDYVPHIPENPNWQYTHHKIEIWYNNSMALGDSYMECDAQESPNCSNSVPVNLLTWNDHGSYFQGGDACRWCQKASISQTTVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTY0</accession>
    <name>A0A914YTY0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914YTY0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3605.t1">
        <property type="protein sequence ID" value="PSU_v2.g3605.t1"/>
        <property type="gene ID" value="PSU_v2.g3605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3605.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="19982" checksum="A2EBFDF2369A1103" modified="2023-02-22" version="1">MSSPTLDSIRQKVDDAVLCVPDFPKPGILFRDIMPIFKQPKLVSNICSAVASHLRESFPHGITAIAGLEARGFLFGPQIAILLDCIFVPIRKLGKLPGATIKASYVKEYGVDTVEIQQGILSPNDTVVIVDDLIATGGTMRAAMEVIEATQAKVIECFVLIELEALEGVKVLPEHCNFVTLLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUC2</accession>
    <name>A0A914YUC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3590.t1">
        <property type="protein sequence ID" value="PSU_v2.g3590.t1"/>
        <property type="gene ID" value="PSU_v2.g3590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3590.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13774" checksum="87450196B376A005" modified="2023-02-22" version="1">MTCFFIENIPVRNLRGVGGGNNQVPVNISSTSTSATPAPEPTQSNPIFTITDAPESFTCNNSDCFRGTSKYRYKKKQHVSLTGFSILSISGFCLSAHFILLMLLLTNKMCASKKKAPKLQSPAPISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVU4</accession>
    <name>A0A914YVU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVU4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3772.t1">
        <property type="protein sequence ID" value="PSU_v2.g3772.t1"/>
        <property type="gene ID" value="PSU_v2.g3772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3772.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28563" checksum="19D58D4F2A356CA9" modified="2023-02-22" version="1">MDEFETLHQLSYLCGKAKCEDLESEVNLDILWEKINTENKAKKLCQNFGDIKNVFTDSDCPFSTRIDVQYYFYKKHQESQITEELCVDRFGRKYPPPEGLGGKCVVFQHEFEKDGKQITEFFMPIEQRDMVQRILQYPYTHEIRKNATTLNRLLPKTDVQIRLQETNCTTLHYYGGMFFHCIYNPDQSHLFLAKETDYFNCPKNEHLSLTSEIGLPVGMVYSIQKIDSDRYEFSNVSFVMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWZ7</accession>
    <name>A0A914YWZ7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5051.t1">
        <property type="protein sequence ID" value="PSU_v2.g5051.t1"/>
        <property type="gene ID" value="PSU_v2.g5051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="6">
        <location>
            <begin position="316"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5051.t1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57324" checksum="C6B864A094B634EC" modified="2023-02-22" version="1">MLLTVRCLTKNGSEWLLSCADKQELPEYKNGKWSKNKLYQGYVYDFGKNKIPNVEVFPGVQIAIEKPEQSVHLDDLIVFKVVDSDDDKSSFKVVNVIREAEAKAELKDEETDDDEEEDDQDSEMQAIKDAMSKLTKGGNIFNASAFTKNTLQSAKESLQTEAKKAAQKRGRNESITSIKTQSDDEVDQEEAMLDDNARILHKEKILSGLEKSSELNDDTDYNRLVLSNPHSSEAWISYMVYQAQDGNIEEARKVAENALNTINPREEQERINLFTAYLNLEVASGDEKSLKAVFERALGAFDAFEIHKRLANIYLSTKKFDDLEKLYNVMLKKFGNHIRDVWSLYGAFLYKQNRQAEGRELMKRALNIIPKKHHLEMLCRFANFEYAHGDIERGKTMLEKAVAAASNRGDIWNVYIDKAIKYQNIDDARLLFERAITNKLGMHTMKNLFQKWQDFEKLRGDEEHLLKVNEKAVQFTKNLKKDIMDAQADEEENGQNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX83</accession>
    <name>A0A914YX83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g426.t1">
        <property type="protein sequence ID" value="PSU_v2.g426.t1"/>
        <property type="gene ID" value="PSU_v2.g426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g426.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7525" checksum="AA70CA5BE0045F17" modified="2023-02-22" version="1">MTDEGPQLKEYAELSLEAYDSFTQNRFGRNYNTLASTLPVAMDYALAWMKLLVALPNVENTLLSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXQ6</accession>
    <name>A0A914YXQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4741.t1">
        <property type="protein sequence ID" value="PSU_v2.g4741.t1"/>
        <property type="gene ID" value="PSU_v2.g4741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4741.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28881" checksum="925772063F564930" modified="2023-02-22" version="1">MRLKRIYRPGSSKQSIRVEPSRSSPIVLEDPTLSQPSHPNTGVVCPPFIFGSVPARPSSSFEHQITTSFTSSASSASSTSSPAVNLHKCFDKSPTVFQYAQDIQIHNVNSQKTGYVLAKIWKIRCPECTNKNLINMQINSEFVVQRTKRDCIPVNAKWAFNCYLNGQSVTNHEIFKLPCVVQTVREITKLFFIELTLAIGEYMCKQVDTSVLYPFVMEYYENRNPMYTVVTKFGVEQNYEIMYTSLIPKLNPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYJ3</accession>
    <name>A0A914YYJ3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYJ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5573.t1">
        <property type="protein sequence ID" value="PSU_v2.g5573.t1"/>
        <property type="gene ID" value="PSU_v2.g5573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5573.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32682" checksum="41962F8DC008D624" modified="2023-02-22" version="1">MISTLFTCSKKIALKCSFRQISILNAQRDPFAVTPEAYITTLSDVEENNVDIIKLNPTIFRTTPRIDLLHRNITWQQGYRNLQLTKQLSRAEMPGGGKKPWPQKKTGRHHAGSIRSPHFKFGGFANGVRGPRTWFYMLPDSIRLKGLCTALTIKHAQNDLIIADDFNSINNNDSQFLHDLAEKRNWGYSILFVDKDSNMPTNFVDAVQDIPSFTAIPLYGLNCYSIMKHDTLVFSKQAIEALEEKLVQQFTRTTSHHKKYRYIDYKDVLLGEGEHEEDPIHPPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ48</accession>
    <name>A0A914YZ48_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine racemase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
            <ecNumber evidence="13">4.3.1.18</ecNumber>
            <ecNumber evidence="14">5.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">D-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">D-serine dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">L-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">L-serine deaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">L-serine dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-serine = D-serine</text>
            <dbReference type="Rhea" id="RHEA:10980"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="5.1.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EC" id="4.3.1.18" evidence="13"/>
    <dbReference type="EC" id="5.1.1.18" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZ48"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5378.t1">
        <property type="protein sequence ID" value="PSU_v2.g5378.t1"/>
        <property type="gene ID" value="PSU_v2.g5378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070178">
        <property type="term" value="P:D-serine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000041">
        <property type="entry name" value="Threonine ammonia-lyase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF19">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="57"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5378.t1"/>
        </source>
    </evidence>
    <sequence length="307" mass="32978" checksum="711F20A8F184D163" modified="2023-02-22" version="1">MLRQLSTVPRSNFFNAFQVRQISTTDSFPTIIDPHCDPSLPLKLNFAQISSAAYNIKSGIQRTECRRSFKLSHSIGSNIYLKMELNQATGSFKERGARQALLRLSDEQKKAGVWAASAGNHALALCYHGKKLGIPINVVMPRHAPLMKIDYCVKFGANVIVEGKDISVSRGIALKSAIEFGAIYINGYDHIDILAGAGTIGLELLDQVSDLDAVIIPVGGGGLIAGVGVAIKTLYPKIQIIGVESETCPSFTKSLESGIPTVTRSLPSLADGLAVPLVGVNAFYTAKEYVDKMVQMNEYCIGNSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZA3</accession>
    <name>A0A914YZA3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3366.t1">
        <property type="protein sequence ID" value="PSU_v2.g3366.t1"/>
        <property type="gene ID" value="PSU_v2.g3366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000001">
        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000167">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF10">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3366.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48563" checksum="5A90A098EE20D8F1" modified="2023-02-22" version="1">MNSTSSRSHAVFTIVLTQTRLNTEFDPPPQRVSKISLVDLAGSERANSTGAEGQRLKEGANINKSLTTLGLVISKLAEDAGKKKKGGPRVVPYRDSVLTWLLRENLGGNSKTAMIAALSPADINFDETLSTMRYADRAKQIVCRATINEDPNAKLIRELKEEVQRLKSLLGDRGVQIDAAGKPHSGARTLAAEEDTIEQLKTSEKLMAQLNETWDEKLQKTEYIKKLRVEELREMGLATGTDGTTLGVFSPTKLPHLVNLNEDPLMSECLLYYLKEGETRVGNPEAQHKPDILLSGQQILEQHCRFVNEDLCVTLFPEPNAQCFVNGNLIVEPTKLTTGCRVILGNNHVFRYNDPQEARQSRHNLAAAAKEPLDWKYAQVELFEKQGIDLKKEMDKKLFEMEQTFRKEMEELERQHKRKNNVSFEFFLKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZB9</accession>
    <name>A0A914YZB9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4974.t1">
        <property type="protein sequence ID" value="PSU_v2.g4974.t1"/>
        <property type="gene ID" value="PSU_v2.g4974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="420"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="506"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4974.t1"/>
        </source>
    </evidence>
    <sequence length="645" mass="76177" checksum="C6697F944B9148AF" modified="2023-02-22" version="1">MIDREFIAELEKKREKVENLFDFEKFKVGSGTYGQVFQAFPKTKNKLFPKKSYALKLIECIDHKQNMILSMSACREIALLRELKHENLIQLNRIFTDQRKVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDQRKVWLLFDYCEHDLWGILTHHRRSETDKFPAKRLVKSIMHQMLQGILYLHNNWILHRDLKPANILVVGEGSKVERGRVKIGDMGFARLFSAPLKTFAEIDPVVVTFWYRAPELLLDTKHYTKTIDIWATGCIFAELLITEPLFLCKEEKPETSTPYNREQLHKIFTIMGFPKSEEWHSLREMPCYERLTKDFMPSTYEKRCLAAYLARYKLQNTLEFRLLEKFLTMDPTKRITAEEALKDPYFFEDPLPTADAFYGIKIPYPPRKYLTDKENNRSQQQMMPPLRHHPQQPQQNIPLQLHQHQQHHQQQQQQVPAVLVKQEHSRGQQPSKQLPQQQQQRYAPYNINQRQPKIEPQQHRDVKPTVTIQQQQQQQQGYYQQQQQQIPRPLQPLQNPSLSSQHELSTTVPKQVHAMQHSQIQQQQIQHNMQQQQTALQMPPIYHPQQQSMMGQNNAMQIRMNSNQHSQIPQQQQQQQQQHLPPGWPQHGIPRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZG9</accession>
    <name>A0A914YZG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZG9"/>
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        <property type="protein sequence ID" value="PSU_v2.g5026.t1"/>
        <property type="gene ID" value="PSU_v2.g5026"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
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        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5026.t1"/>
        </source>
    </evidence>
    <sequence length="489" mass="55402" checksum="E500AB5C5EEA431C" modified="2023-02-22" version="1">MMVESEDSSASQTLSGPPQEHMCEIDLRGYHACTLKINRFGTAVAIGTHSGDIVIVDYTTKIIVKELKGHPLPVSSIDWSNDGKLIASASEDGTANVFNVETTEILCSYNFNSCNNQIHFHPRDNNIVTVLKPKDSSITSLKLDKKEEVKYEYRQKPQLSEDNITTIAYSQRGKFLIAGTNKSNLILFDAKTFKYVKHMKQANNHQVRQIYVSKKKDLVVTNSSDRYIRVFKLHSIVNAKAGEMVAYDSRYSDAVSKRNYMFVGMSPDARYVCAAENSAHEITIWDLWTQTVATPLRGTVGNIPSDLQWHTTRQEILTVAGGKVHVFGRRIVTTMSAFAPNFKEINDNFIHEEEEGEFDMGDEDADEPIKIAEDDVEVDIEALPLSDMPWKSDDEEDYDLNEAEKHGKAPLIMVPASLENIITYDVDDDSDPEYDRLEPEPPVKRKRDDEIFRKPKLPDFSNINRSRMSESSSTSADTRLPKIKRARYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0V0</accession>
    <name>A0A914Z0V0_9BILA</name>
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        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0V0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3900.t2">
        <property type="protein sequence ID" value="PSU_v2.g3900.t2"/>
        <property type="gene ID" value="PSU_v2.g3900"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3900.t2"/>
        </source>
    </evidence>
    <sequence length="409" mass="48034" checksum="7D3B7354B7CC0BEF" modified="2023-02-22" version="1">MQYDRYKVFESQDMEKGQFDLVLEIEEKKLYVHKFYLITASETLGAMLSDRWNTTPNEAIKIENYSYDDFYEFMCFIYCGTCALTNENIMALTDMAEFYGVPLLKDYCDTFLCKTNNYVNIKNIEKMVELAERYSLTKFTVALQRCIRQKVSSFVYDKNFINFEKSFVKFLAGVERYENVESEFFEAVFKWAENQALIKKKMSEDENFNLQDAIKEELIDFLPKIKFNAMSVVFIANNIIRDKPYLFSTFECYKILMGSKRYDRDNVLFKAVYELAEKELNEKQKVSASDNFNFEDAIKCELAEILPCIDFNNMPLDFIISFILPDKTFLFSTSQLYGMLITSRRYLQEEAFFKAIYGLAEKEALEKQKGSSDDDFDVESAIKSALVDILHSVKFEDMNLDFVIKFISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2H4</accession>
    <name>A0A914Z2H4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2H4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6910.t1">
        <property type="protein sequence ID" value="PSU_v2.g6910.t1"/>
        <property type="gene ID" value="PSU_v2.g6910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6910.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21632" checksum="3F6A838E4B7C246D" modified="2023-02-22" version="1">MRDLLSLFPKTALKNVFFFFTYANSTFFNIGDTRNTLEEFISTFKETNNAEIPFGAENVYCVDSEAFMYFIATNQGHKYQNRDLESFRVSWNKSKAAVETFLVKVENVKPIKSDDLLMTYELEQIGTMLRKEKDPKLAELIEIILTKISQISMSSNVLNLPRTCHRFKFKAVYTKIGRSLWGKDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2U2</accession>
    <name>A0A914Z2U2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2U2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6201.t1">
        <property type="protein sequence ID" value="PSU_v2.g6201.t1"/>
        <property type="gene ID" value="PSU_v2.g6201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF2">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="217"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6201.t1"/>
        </source>
    </evidence>
    <sequence length="460" mass="52066" checksum="8C18A36836D1CCC0" modified="2023-02-22" version="1">MLRYFLTQIEVIPCKVCGDKSSGVHYNVITCESCKSFFNYWNIFSAEEKQCFYEGNCPINLKTRKECTFCRLKKCKDLGMHISKNDEKVDNEVKMYRQLAEVQTYQQPQHNDYSQYEVYPAQSSTTTSIPTFAPQSNGIHISSGNTSQYAPPQLHHPLAGAAPIIWPTPQSSLGGVTAANISNGHNGYALSQAGAAVPCSSGGYPDSLLSQHIIPNADDGFISTILNSYEQNFVKQLFERVDDGNALPGMFMDLSRNDAWLTFTDKLTKIMYNIVEFAKSVPTFAELQEENQINQLKRNTFDMCIVIMSCGYNGEQDTLNIDGVYVPVRQTLQTWPQESNETALALDIVQCFQNLTAFHLTQVEISLFLVIILMQGEEQQVIFTHKLQTNLHNNLMHRYGNETVFARLMEMLPGFREISDNHLRCLNDFRVETQTAAFVNGMPRVKLPDLYVELFSLDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2X1</accession>
    <name>A0A914Z2X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2X1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6695.t1">
        <property type="protein sequence ID" value="PSU_v2.g6695.t1"/>
        <property type="gene ID" value="PSU_v2.g6695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6695.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23049" checksum="48C6AF6E0EF48949" modified="2023-02-22" version="1">MTLHFFGCYILNNTRQKFYDLDPVESFDSANNVGLRNHYICSTYAARLMVPRKNGLIVTVSSSGGMAYLFNTAYGIGKSGCDRLAADIAVDLCEANITSLSLWPGPVKTEIIHKRIIIGGESNPIKGVFDAGETIEYSGKCVVALASDPKQMQYNGQILTTADIGRKYNLFDDDKTQPKEMAPRFREFIDCLNKIRNPADYRENAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z304</accession>
    <name>A0A914Z304_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z304"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6439.t1">
        <property type="protein sequence ID" value="PSU_v2.g6439.t1"/>
        <property type="gene ID" value="PSU_v2.g6439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6439.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11245" checksum="18174CF83BB80D9A" modified="2023-02-22" version="1">MAQVNPDDLKLPMAPIVKLMKNAGGDGMNFSNEAKTSIARAAAVFCLHAAESANEFAVKDKRKTITAADIVNAMDSLDVTEFKEEIQATIEEYRAAKSAKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4I8</accession>
    <name>A0A914Z4I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4I8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7269.t1">
        <property type="protein sequence ID" value="PSU_v2.g7269.t1"/>
        <property type="gene ID" value="PSU_v2.g7269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7269.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19441" checksum="45F7B8039567E298" modified="2023-02-22" version="1">MENLENIFSPVDEDDENDMEEDEHNAEEQVIDDAMDSDDSSNVDEYSDSSDLDRELDNQQKSQNDFEEVMEHDFDPPIQLNENFLNNEQHYETVNDFEEEEMESESDEPIFPNEDLPQSKFCDENVPSEGFTYVEESNFTFRRFLNGKYQLQVFADDDRTNCVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4X3</accession>
    <name>A0A914Z4X3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4X3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6947.t1">
        <property type="protein sequence ID" value="PSU_v2.g6947.t1"/>
        <property type="gene ID" value="PSU_v2.g6947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF2">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6947.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17816" checksum="DF4BF336A284361E" modified="2023-02-22" version="1">MTPKAVCGDCFYTVLGVDKSADDIEIKKAYRKLALKWHPDKNENQEKEKAEKKFKQIAQAYEVLSDSKRRADYDNRLAYRQTHRRSTSSSPNSPFFAASSFRSPFDIFREFFGDPFKDFPNENFKTTFSPFYDDDDSPIPRRKRHTHKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z562</accession>
    <name>A0A914Z562_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z562"/>
    <dbReference type="WBParaSite" id="PSU_v2.g749.t1">
        <property type="protein sequence ID" value="PSU_v2.g749.t1"/>
        <property type="gene ID" value="PSU_v2.g749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="330"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g749.t1"/>
        </source>
    </evidence>
    <sequence length="752" mass="85924" checksum="AA556008D8A3926B" modified="2023-02-22" version="1">MRRNWCEWEDWWLLKAIDSTPEGGTKSETVRLFRQYAGANLVSGRTDGGVVKRISSLSLINGASRKRTHEMASVDISEEEERFKAVEDQVQRCIQDIKIVLESKECKSFWRKGLSRVRGQKKVLEIVLKAIHRIITDESVRFEAIGEINKLCYAAASVAIKMSRKPSELSDWEVKNKEALESNRVLKQHVQMLIQRSSNKKRISSSDELRLTKDERSILRKLRSIKGKEYYTLQDWSNFADHREKELVEFSKIQIKSKNRLHSRHKSAKTILDKPCTEVPFDKEEFRMCWEASLKKTKPLKAPGPDGIPAYWWKTFELLEIRMRVALEGIASGEKRPPNWFCQGRVVLLYKKGDANDPGNYRPISCLNTCYKVLTGALTISLLSHCYKEKILNQEQRALRKGEWACFVSHVIDKVVKQALMNRKESYSVLWIDCKKAYDSLGHKYLKEVLGKIGIPQWMYNSISNIMSKWSLRYTMGTTVSQSLNVLNGVLQGDVLAPLLFCIGLVPVSHALRKLIPVIKLKGSVPDDVYSGWLNHLFYMDDLIAYSLSSAVDDTFGIIKDCLGAAGLEVNLTKCAVLSRNRDGNLELPELSLDETYRYLGNEDEWVTDEAKSSEIAAVACQVKMREIWLSDMSAKQMRIAHNSCIVPKIGYLYSTLATAKNAYNVSHKRAEDLDMSLVRLLKENCIMNHSGNVNRLFLPIKMGGLGIRSVADHLDVQAVRKALYMDFMPGMENMSDRLKQIALTKKQKRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z635</accession>
    <name>A0A914Z635_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z635"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5704.t1">
        <property type="protein sequence ID" value="PSU_v2.g5704.t1"/>
        <property type="gene ID" value="PSU_v2.g5704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF16">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="2">
        <location>
            <begin position="123"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5704.t1"/>
        </source>
    </evidence>
    <sequence length="333" mass="36222" checksum="75061372025E86B0" modified="2023-02-22" version="1">MEKSKVIQFVFIALIGVICIIILSLVVAILVKVYQKDDTSENSTTTTTTTTLSLTSMSSSGSSMGNFTSGILPTTSNPIITSAVTSSITISPTTTMEIPASPKCPNPQKSNLPLASLPGAYDTLSWGTFRAPLYFGLRMRHSDSPLFGLMWFRQTTTAHNLVLKHYCEDDGVRCMWSDADGETFGSQPIVDVKDNKTTLFSTDWIRVNRSWEAQISVETNETVAFIFYFAYQDTVSNLSASYSVNTLSSINGNFVPLGNFQLSFSSTGKIVNDASLIINIEPMLDAGIVNELILSSFLPCKDASSNICIDNGGRPPDQTPNFAAIQFTVNGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z658</accession>
    <name>A0A914Z658_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.16.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z658"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7817.t1">
        <property type="protein sequence ID" value="PSU_v2.g7817.t1"/>
        <property type="gene ID" value="PSU_v2.g7817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04904">
        <property type="entry name" value="ACT_AAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="8">
        <location>
            <begin position="90"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7817.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18007" checksum="49084FF58A5A64F5" modified="2023-02-22" version="1">MESFVAEVSTNPANTTIIFTLKETPGALAETLRIFKDKKVNLSHIESRPSKNKEGCYEILVEVDESADKDRVEEIISLYKRKAENIHVQDFNTQVKQNKESVPWFPMKMKDIDQFANRVLSYGAELDSDHPGFTDPIYRERRKQFADIAANYHIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6H7</accession>
    <name>A0A914Z6H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6H7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7533.t1">
        <property type="protein sequence ID" value="PSU_v2.g7533.t1"/>
        <property type="gene ID" value="PSU_v2.g7533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7533.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20851" checksum="DE35E45222E5E680" modified="2023-02-22" version="1">MDFIYPHIRPCLGFCINYEQCLHRLQDFYFPTWRLEGSLPSSWPRELDDYESRLLEHSFKWFGTKSSDYDIKLKTAFYFEPQQQSPQLTAAYQQLKRCDVEKLFFLDFDRRTFLWDLRSCVGLFDRRLAKDYREDAVRIFKDFNVFINEATEGVYVWDWILKKKNKFGNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6K0</accession>
    <name>A0A914Z6K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6K0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7531.t1">
        <property type="protein sequence ID" value="PSU_v2.g7531.t1"/>
        <property type="gene ID" value="PSU_v2.g7531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000078">
        <property type="entry name" value="Cyclic nucleotide-gated channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF1">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL SUBUNIT B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="613"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7531.t1"/>
        </source>
    </evidence>
    <sequence length="844" mass="95417" checksum="C398F44700705FAE" modified="2023-02-22" version="1">MLNHKNCYVLQPSIIRLQRHLPRKETSPDESQIPFKHRSRPFTANFRPRTAKAKKQPEIVGGEDLEKSVETIIARRRKTDSSTTTSSSAFSIPRPLPPSPPARVTTINEEGGDSSTPPFSPILLPPTTTTTTNPEIVFEAASREISQNSGLSPREQFEVMLDIDTSGQIQNPEAPSNDTEADVPQEEEKIVIIPESEREQMEVMLDIDTNAQVQSTENIPSKIETKEELKVIKDSIHSAIKIITPSASIEIHEPSDESFVEEEPTGISSFLTVPSEATSRRSSEIDSEDGRSSIQSRLSFIVQAKLHHYANDLRRRTSQVMEEVIQMDDDALSDDESEAAAAGAQQDQQASLMSLIGFDPDADTQTEISSRRQCFPHHIDPFTCLLPLDLFYIVAGPLAAFRIPRLLKIYAFWEFFDLLDSSFSNPYAIRITRTFCYMIYIIHCNSCVYYMLSAWQAFGQLAYNYKGQWYLNKWVYNNQGNAYIRCFYFTAAVATSTGNNPPPTNVIEFAYMTFSWMMGVFVFALLLGQIRDIVYNANKNAEEFRATMDKALGECKRLELPAHVQEKVRAWFMYTWEQQKTLDESKLVDKLPLKLQTDLALSVHYTTLSKVQLFQDCDRSLLRDLVLKLRPVIFLPGEMVCNKGDVGKEMYIVNQGVLEVVNDEKTKVFATLGEGVAFGEISLLAIGGNNRRTANIRSKGYSTLFVLSKEDLNDVIKDYPEAQILLKKKAKQMLKKDKSKSSKSRKDLRDDLVKISSVSAALPTPRMLSAVAQLLPKESDVAKELHFMMNKSNVKPQRLKRWSTIPDDVSDISDTEFPKQRLSGIHKSRSFDLGDFNNRKNAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6L0</accession>
    <name>A0A914Z6L0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6L0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7540.t1">
        <property type="protein sequence ID" value="PSU_v2.g7540.t1"/>
        <property type="gene ID" value="PSU_v2.g7540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7540.t1"/>
        </source>
    </evidence>
    <sequence length="594" mass="69303" checksum="57310DD18E99B8CD" modified="2023-02-22" version="1">MKRSFMGGEEEDEANKNEKQPRKLNSENNLSNENDGNSGCFSGSNAVDSNINILECNDIALKEINNEKGAIGDLPSLNDSFVNNISIDLSTENVNLKNRITELEKDLTCLQKRHNDVLNIKEGFNKKESKIRSKVYTERNQNAERAKIAEEIVKILEGQLLKSQEMVKSKDVSRLEVQHQLNNAQKQIIDEKNAKEKALFEVDELQIEMKQLRENLANKDNLIQHMNNKFNGQSASKEEDTVTIEKLQQQLSTKEKTIEDFQRRLEKAYESVENLKDEKSETLFENERLKICDNELRNSVKAAKENINKLENQLEEVQKQLFHQNNNKNDEISREKDFFVAKISEFREIIKEKNQQIASLQKDLNVEQVFCNEKIEKAKAETKLMEEKLTQTTHDFNQLIQKYNDIKLQKDNQIAVAIEEKKEFEAKMDTLETKEFIKTAYDAQQREGLRASEAAEKVLQIEAKYLQCQTQLTKEIEERWKIENRNKKITEELGDEIVANEKVKSDLEKEISKLRDELLKVEEKRDELKKKFNESENERENAAIKYKKLEESNKNLTKEIVKVQSEFAASKQEWKENVKKFAELHESLNAFCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6L5</accession>
    <name>A0A914Z6L5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6L5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7971.t1">
        <property type="protein sequence ID" value="PSU_v2.g7971.t1"/>
        <property type="gene ID" value="PSU_v2.g7971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="199"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7971.t1"/>
        </source>
    </evidence>
    <sequence length="501" mass="57984" checksum="F9E759497F1F3876" modified="2023-02-22" version="1">MKLVAAEKMDDQDKIILEKQHSSPLESSSPLSATSDSSSRKSLNLSDFSTASFPSFIQFPSSLTQLQHVHIQIPLGNGLIDDKLYSSGLFHGVIITDFLETISKKSGEYFFVVLLDEENEIFLGNSKLFFIVSMGNEDYYQKELIITSDRKCLKIKGSTEEFEDIDKLISTLQEDEIKYFKRKIMKHPLRRFSWIYHSLIPDIQQSLGDFTTVAYCDTIPYFKGQVVFHRMNASIESAKKLYNEVKVLSKINHTNIIKFYGFSAFQEIALLTEYCEGGSLHSMIYKNEEYSKNLPEFNRLRLLFQLSEALIYLKSRAIIHRKIEPKTILLTVNLDVKLSNFSCAGIHTVDMVKSKSQSKSIFHKFRWSRYKKEELAEMEFPMTNLPESILEKILKESPYISPETAVNHVFSCQSDLWQFAMTMYELYSQKQPFHFSAGPMYQLHNLICTVSTWKNLPRGTNLGLQEIFKKCTVRFGSDRMKIENVKEKLHDLLIHLNESRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7B0</accession>
    <name>A0A914Z7B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7B0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7773.t1">
        <property type="protein sequence ID" value="PSU_v2.g7773.t1"/>
        <property type="gene ID" value="PSU_v2.g7773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF46">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7773.t1"/>
        </source>
    </evidence>
    <sequence length="595" mass="67648" checksum="BAB4A8C815E099EE" modified="2023-02-22" version="1">MDRTLSLPPDVKNIITTVPDPIIRQKSHIKSIVVYNSPLKSKQPYRLQLLKVKAERLIAEKKLKNKLLALKQKSVLQQRQRLKRSPYRLFNEGEKEYDNYLTKNPIKSMAQMESLVLTKPKTPIQTLTRALTNLVRTIDPPRNGKIEPWGNSYKKLLNLNNSLKDQYQRRSYRRRMLDFVTNSKGSFQSNKRRVSDEFRHLLPEKGLPKLFKNALSLADTIHQHTNSTKFTFLSPKFGSIVKQDKYASNRFLSPNILPFYKDDSAILPIPEVLEATGMSKDDENAVMELVMEASGANNMVQDIVRILNETDIATFAPDIDGVSNIILNAFQKFSKGLHPRQKRQLKQRHYTFIKAEQLREFVGKNGSVLVGSFALYLMDILGLYNTSDYPIDIDDYSTWSEVKKKRVVMNAIRAIAAAPNDFDVENMVNYHLNPSLKEKHRRYKRQGIELELEADVLSPYMFAPLYQEPQILGPIILSPGIFSPPVMSPAVLSPCILSPQFMSPLIFSPYILSPNILSASAFLPYILSPYCLSPNILQPYLFTPLILSPHIMCPDIMSPTLLSGIILNPFAFSPAVKTTSFLAIEVLSPSAFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7B5</accession>
    <name>A0A914Z7B5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7B5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7778.t1">
        <property type="protein sequence ID" value="PSU_v2.g7778.t1"/>
        <property type="gene ID" value="PSU_v2.g7778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7778.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8924" checksum="4272D3429026FD77" modified="2023-02-22" version="1">MAGKGKGTLSKTDGKKKQTTRSSRAGLQFPVGRIHRHLRKGRYAERVGNGASIYLAGVLEYLTAEILELAGPYHSSAYSTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7J9</accession>
    <name>A0A914Z7J9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Autotransporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7J9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g830.t1">
        <property type="protein sequence ID" value="PSU_v2.g830.t1"/>
        <property type="gene ID" value="PSU_v2.g830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.130">
        <property type="entry name" value="Autotransporter beta-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005546">
        <property type="entry name" value="Autotransporte_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051551">
        <property type="entry name" value="Autotransporter_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006315">
        <property type="entry name" value="OM_autotransptr_brl_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01414">
        <property type="entry name" value="autotrans_barl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35037">
        <property type="entry name" value="C-TERMINAL REGION OF AIDA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35037:SF3">
        <property type="entry name" value="C-TERMINAL REGION OF AIDA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03797">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51208">
        <property type="entry name" value="AUTOTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autotransporter" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g830.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15499" checksum="6C5877903A631753" modified="2023-02-22" version="1">MTPQGQLIYANASFDSFTDRFGADVSRKRADSLEGRLGLTLDHQDSWLNDRGMMNRRYVYGIANLYTEFLGGTEVDVSGIRFANKRDRVWGGLGLGGSYNWNDDKYSIYGEGLVLTSFNHFADSYGYKGTIGLRVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7T4</accession>
    <name>A0A914Z7T4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z7T4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g875.t1">
        <property type="protein sequence ID" value="PSU_v2.g875.t1"/>
        <property type="gene ID" value="PSU_v2.g875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000001">
        <property type="entry name" value="DNA gyrase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000002">
        <property type="entry name" value="DNA gyrase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050220">
        <property type="entry name" value="Type_II_DNA_Topoisomerases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF5">
        <property type="entry name" value="DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g875.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32060" checksum="4329CD1F9E0CEE91" modified="2023-02-22" version="1">MIEIIPGPDFPTGGLILGRAGIYSAYSTGRGSVLMRGRVAIEPMRNDRESIVITEIPYQVNKATMIEKMAELVRDKRIEGISDLRDESDREGYRVVVELKRDANADVVLNQLYRYTPLQTSFGCNMVALNGGKPQLLTLMEVLNAFVHFREEVVSRRTKFLLNKARERAHVLVGLAIAVANIDEIIALIRRAPDPATAREQLMTRRWPAADIAPLIRLIDDPRHVLNDDNTYNLSEEQARAILELRLQRLTALGRDEIADELNKIGEEIKDYLAILASRRNGCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8F5</accession>
    <name>A0A914Z8F5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytosolic purine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8F5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6533.t1">
        <property type="protein sequence ID" value="PSU_v2.g6533.t1"/>
        <property type="gene ID" value="PSU_v2.g6533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046037">
        <property type="term" value="P:GMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000021">
        <property type="entry name" value="NT5C2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6533.t1"/>
        </source>
    </evidence>
    <sequence length="562" mass="64466" checksum="E36BDC8310F0AF24" modified="2023-02-22" version="1">MFDDLATHKRSPENRVFVNRNLRLEKIKFFGFDMDYTLAIYKSPDFESMAFDLVVNRLISLGYPEDLKQFKYNPIFPVRGLWFDMIYGNLLKVDGFGNILMGSHGLNFVTPAEIEECYPNKFVQLIDTKIYVLNTLFNLPETYLIACLVDYFDNSSEYTKTNDKTGVKSGDVIMSYKSIFQDVRAAVDWVHFAGGMKKCVLENLSKYVENDPRIKILLSQLRENDRKTFLLTNSDFTYTNGIMKYLIGEDWTSYFDIAIVDAHKPRFFAEGTVFREVNTATGALKIGIHSGPLCKGAVYSGGSCDAFRHLLKMKGRDVLYVGDHIFGDVLRSKKTRGWKTFLVVPELNHELSVWTGRKPLFEKLGELDSKMAELYRNLDGKTRSKPEISNILNAIKEVTYEMDHEYGILGSLFRSGSRTTFFASQVERYADIYASSCYNLVHYPIFYFFRAPMMLMPHESTVDHAAVMHQKSHRLHHQDSVGDQVRDWNKLNLKSSTFCHEEDEEENDTHSSSDTDNGDSSRRPEHEDSAEVGIHNQENSHEQKGPSADVVVENQAFVERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9F9</accession>
    <name>A0A914Z9F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein transport protein Sec24C</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9F9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9308.t1">
        <property type="protein sequence ID" value="PSU_v2.g9308.t1"/>
        <property type="gene ID" value="PSU_v2.g9308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000020">
        <property type="entry name" value="protein transport protein Sec24D isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="9">
        <location>
            <begin position="417"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="10">
        <location>
            <begin position="494"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="12">
        <location>
            <begin position="742"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="11">
        <location>
            <begin position="837"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="8">
        <location>
            <begin position="961"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9308.t1"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120715" checksum="B678BB66A27E2834" modified="2023-02-22" version="1">MQVPASGQWNQPPQQGIPGNPNQVPSTATHNSWNPNPQPPMSTAWNQIPQSAAPATWSQAPQHTTAAAPQTHNSQPLMPVNQNKLPQPPMPAPQNQAPVSSTSGNFNSGLSHGMPQHQSQAPQHPLQSQPNQPPTSTFPGANINSAASAGIPNQNQAFPSGPPGLNPSNPASLPGQPGMPPAWNHAPQPGGPNGPSGMNPSAPPGMNPPGIQSPGMPNSWNQAPQSGMQAPWNQPSQPGMPGAPGGMNPAMPPGMQPPGMQPPGMQPSGMQPPGMQPPGMQAPWNQASQPGMPPGPGSPPGMPGGWNQSAPPPQRLDPNSLPSAIQVIEDDRQTRTGVFPTGYPTAEHPPLVSTDFVANDYGNSNPKFMRSSFYSVPATQEFTKQSQIPFCISTTPFAKLVPGEVEPPVVDLGELGPVRCQRCKAYICPFMEFVDGGRKFRCPFCHTSSQVEETYFAHLDHTGRRTDIQYRQELYLGSYEFIATKLYCKNSVPPKQPAFIFFLDVSYNAVRSGLVDIFCKQLPFLLKNLPKDYNQERSSMRIGFATYDQTLHFYNLSNPHRAEMLIANDVSDVFVPFVEGFLVNFFDAEEAIKLCLEQVRTCFADTRITETMLGPVIQAGMDALRSADCAGKIFVFHTSIPTFEAPGSLKNREDRKVLGSDKEKVQLLPGTEFYTKLGEECIKIGCAVDIFLFPNSYLDIASIAPVSNISGGSIYKYQYFDAERDGQRFLEDLQHDISRAVAFDVMMRVRTSTGIRPTGFYGHFFMQNTTDIEFGALDADKNVVVECKYDDKLDEKVPAVFQTAVLFTSCGGQRRLRIHNISLQVTNDYNAIYRFADQDTIVTYLLKHAAKLIREKTPKEMKDELYQRGAQILATYREKCSQQSPHTQLVLPECLKLLPLYLSCIVRTDALNGGSELNVDDRVWLLQLIPSMRTDICMRNLYPQILPITNLEIAENNSQLIMPTPIRASYDYMNSNEVYFIENGIVGFIWIGLGAPIQFINDVFNAQSIQHLDTESQVLPERDNDRNRAVRKLISNVNASRPLRLKIFIIKQQDSLESWMKKFLVEDKYAANTVSYVDFLCQLHRQIRGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9L3</accession>
    <name>A0A914Z9L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9L3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8496.t1">
        <property type="protein sequence ID" value="PSU_v2.g8496.t1"/>
        <property type="gene ID" value="PSU_v2.g8496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8496.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16352" checksum="9F5082A927ACA196" modified="2023-02-22" version="1">MLEYPFALGWTISEARLKALKDSIEYEYLESDKLTAINSSGVKYFLRIYPNGNKENNHGKTWIFLRLELGNEKKVEAEWTISIKTADWSRKMDDTFKKNSGWGSSCCTTDELFDSNKNFIVDGKFTIKVEGIFKKLQMLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB82</accession>
    <name>A0A914ZB82_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AMP deaminase 2</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">AMP deaminase isoform L</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZB82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7509.t1">
        <property type="protein sequence ID" value="PSU_v2.g7509.t1"/>
        <property type="gene ID" value="PSU_v2.g7509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7509.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="59698" checksum="278A157BC4FCB34E" modified="2023-02-22" version="1">MIADGPLKSFCFRRLSFLQTKFQLHVLMNELRELHEQKSVPHRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKMKTEKDKVVIQQGGKDITMKQLFEELGLDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGQSSLRDVFIKTDNYVGGKYFAEVLKEVFSDLEDSKYQQAEPRLSIYGRKRDEWDILAKWAIEHDIWSPNVKLMIQIPRLFDVYRTKNMLKNFDEFLDNLFGPLFEATNDPSSHPELFRFLKHVSAIDSVDDESKHEYVHFDFSTPEPPKYSDKENPPYSYYLFYMYANITALNAFRRQRGLNTFALRPHCGEAGHINHLIIGYLTSESIAHGLILRKVPVLQYLYYLTHVGIAMSPLSNNSLFISYHRNPLPEYLMKGLNVSLSTDDPLQFHFTKEALMEEYSIAAQVWKLSTCDMCELARNSVLQSGFEHEVKIHWLGPNYREEGVLGNDVARTNVPDIRVSFRHEALIDELCNLFKTQNIHASAETPIALTGVKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC07</accession>
    <name>A0A914ZC07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9858.t1">
        <property type="protein sequence ID" value="PSU_v2.g9858.t1"/>
        <property type="gene ID" value="PSU_v2.g9858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="7">
        <location>
            <begin position="129"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9858.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24114" checksum="A4F0E20B6B9BB4DA" modified="2023-02-22" version="1">MQTLNLRQSSFNTGDSSFDLLPHSSNLGTPPRGASKSSSSILLLRQIRYAASAPEIIINEIKSDECKNEKLENYAVSGLEESPGDADEIEEEEVEEEEEEEEMEDDEDDEIPAAAAETTNSCLLFHSTPNKNLIHELIDVDRLELLINLRGLQIRGGPPNCDETAAASSRLSRIGDEIVEQLVEWTKVLPFYNELPVEVHTHLLTQRWSELVCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC72</accession>
    <name>A0A914ZC72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZC72"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9331.t1">
        <property type="protein sequence ID" value="PSU_v2.g9331.t1"/>
        <property type="gene ID" value="PSU_v2.g9331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9331.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14604" checksum="2AB0F38167AB318F" modified="2023-02-22" version="1">MHQLGSHYLGRIFSTKEDIYKYVGIILLTVQQASMPLMVRSTRYRKENDVFITTVNVFIMEVVKLTVCSAILIGKDKSITKFINSLKTAIFEDIGETLKICIPSIIYILQNNLYYIALTNLEATTFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCJ4</accession>
    <name>A0A914ZCJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9429.t1">
        <property type="protein sequence ID" value="PSU_v2.g9429.t1"/>
        <property type="gene ID" value="PSU_v2.g9429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9429.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11409" checksum="7191ADE6EFD33460" modified="2023-02-22" version="1">MTSRRYSELSNASNMSLIDEGDENSTPVVGDNSTPRAKLVPMKKTRISDSPLTSRQQNMAFKGDKNLEETFVEQSFLAAPLVAESEMQTLVKDITQQLCCFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDL6</accession>
    <name>A0A914ZDL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8360.t1">
        <property type="protein sequence ID" value="PSU_v2.g8360.t1"/>
        <property type="gene ID" value="PSU_v2.g8360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8360.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18207" checksum="7DB5F82727EEBD55" modified="2023-02-22" version="1">MCWGHFPNTNIDCLKAYKENAVFIDVSFNRMVHEKTYERASITGMNLFHQISGAVALWTGISMLIFAEMIEVLWFGIFTPNISPRVGSTDNISGMSKPKGSNNSNIYDSNMASEYANDVPQPFTSHASGIGLIAGIPSQDYMPKDFDNPEFTAASQVEPKFCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDM6</accession>
    <name>A0A914ZDM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8371.t1">
        <property type="protein sequence ID" value="PSU_v2.g8371.t1"/>
        <property type="gene ID" value="PSU_v2.g8371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8371.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10783" checksum="83706094885C9DA6" modified="2023-02-22" version="1">MEKVGSKFDISKMGVEIKAKNSDYEKLLSIQSVEESFSSELTELFGCSYIKISNSGNSVTDATVIDSPRKHCGRCRRLARLESDRLCDRCLNAVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDX0</accession>
    <name>A0A914ZDX0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDX0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8471.t1">
        <property type="protein sequence ID" value="PSU_v2.g8471.t1"/>
        <property type="gene ID" value="PSU_v2.g8471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 9" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8471.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52240" checksum="0CBC6373D9BF2A45" modified="2023-02-22" version="1">MSINSVAPPPRDKWSSWADFIMSCIGYAIGLGNVWRFPYLCYQNGGGAFLIPYVISLIFCGAPLFILETSWGQLVSVGGLGMFKICPIFKGVGIAAAVMAFWLNIYYIVVLSWAMAYLVNSIRADDNVPWRNCNNTWNTKHCRSEYDPILCESNRTIAEYFNVKVLTDDHLHEYKKQFFIGPKSNFLFGVKWTGKIVYLTASFPYIMLVCLLIRGLTLPGASLGLEFYLKPDFSKLLHSKVWVDAVTQVFFSYGLGLGALVALGSYNKYHNNVYKQAMTVCCVNSGTSVFAGFVIFSFIGYMAVQQGKTVAEVAQSGPGLVFLAYPSGILRLPFAQVWSILFFSMILSLGIDSQFCTMEGFFTAIIDEFPEILRRRKYGREIFVLVICLISYLLGLSTVTEGGFYVFQLFDFYAASGWALLWLLFFECIAVSWCVGIDRWYEHMKSMIGYYPAAWWKFWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEK3</accession>
    <name>A0A914ZEK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZEK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8710.t1">
        <property type="protein sequence ID" value="PSU_v2.g8710.t1"/>
        <property type="gene ID" value="PSU_v2.g8710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8710.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29417" checksum="2FF653F98F6385C7" modified="2023-02-22" version="1">MPEIKWFLRCCVGDKSSILRRISFYITIKSEVAVDYRLEFTSIYQKDKCSFNSCCNGIERIELNVLNPEIIFKTYSFIKHKKVFVKVCGNFSYKTQPSSISLKNIVGEWGLHLMEKMTHDFDLINENRIITTSKLLLAAESDVFERMFHGNFTEAKENKATIQGYKTVTIQTAVDYCHGKNIFEFLENQENAIELLYFTNQYDFKTLKPKLEKHFATKLSKENIELFLSISDKANALELREACIDFLEIWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEP8</accession>
    <name>A0A914ZEP8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZEP8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8757.t1">
        <property type="protein sequence ID" value="PSU_v2.g8757.t1"/>
        <property type="gene ID" value="PSU_v2.g8757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="50"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="239"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8757.t1"/>
        </source>
    </evidence>
    <sequence length="567" mass="63827" checksum="0AB2718C77091C00" modified="2023-02-22" version="1">MGKKAKSKPIIEEETTTESGFSQFDLDERILKAIGELGWEKPTQVQESLIPLALEGKNILARARTGSGKTAAFLLPIIQNVVQISSSNEEEAGPYAIFIAPTKELASQIFKLLIQLTSPFPFLQCINFAEMDESNVETMLGEVVDMIVSTPGRIVNAVATKPSLLNNVRHVVLDEADLLLSFGYKDEMEKIKEALPKTYQSIFTSATLNENMDDIKAMLMTGPVVSLKLKEGQLPGSDQLTQYHINCQSDEERFTILLSLIKLKLIVGKTIVFVSSTDRCYKLSLFLQAFKIQSCILNSQMPANYRCHIVREFNEGRHQFIIASDMNDIAPKESEAAAATAEDEPPAKKKKKQKKPKKGKRKMDKESGVARGIDFHFVSNVINFDFPTSTDIYIHRVGRTARGFNKGTAISFAIPTEMPLVENVHEEINEMMGEDKILPYNIRMKDFEGFQLRAREALTACTKTVIREARLGEIKQEILRSKQLEAYFSKNPREKAALENDKKLFKVNLHSTSIADVPDYIVPKPLRGQDYSVKTNSSVNRNRKRKMSAGQKKKKQKSMDPLQSFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZES6</accession>
    <name>A0A914ZES6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZES6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8787.t1">
        <property type="protein sequence ID" value="PSU_v2.g8787.t1"/>
        <property type="gene ID" value="PSU_v2.g8787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="533"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8787.t1"/>
        </source>
    </evidence>
    <sequence length="1035" mass="119232" checksum="86AF744B185E49B0" modified="2023-02-22" version="1">MAWEVDGFEEKVPKISNTFQHLNVSNMITVDFDKRDITVILMEVFEKYEKNIALKSEKAEITYKNLQKQILQISNQIKEEYFKAFGCLFGPDTIIPVISKNSIEQWLICLGVIFAGGAYLPIDAKTPEERILKILKQLAPTLIISDEIIPSYKSMALTELISNNVVNSRSMFKTSPTNAYNLAYIIFTSGTTGIPKGVCINRLGISNLILGAQKFLSINSNSIIYQFTNFCFDNSILEVFAALGSGATCFISDGYFSADKFCQNITDYGITHAMLFPGLIETFDDNELAQFEQLKYWICGAEKLSENLFKRAMSLGINIIQNYGPTETTAYCLRKKLGPKDDPQNLGTPIQNAIVTVRRPDGWEAMIGSKFELFIASVGLTRGYLGRKWKDQPFVTFGDGLIYYPSGDICQRLKSGDIRFVGRKDNQVKIRGFRIELDEIESCLLGYPTINTAKILLNQKKEDIIAFYSSKIQIEKKELKDFLKQKLPYYMIPRFFIFLETFPFTSNSKIDTKKLIEYELKSFKGISFDGTNVPMETAIKQIWKNILNLDSSNFDLNDSFFYLGGNSLTAQKLITRIKNELKLEIKMEEFYRNPTISSIFKMAKISQEESIQIFNDDLSVFDKIPLSYQQEQMLYLEQIDPESSYNLTFIQEFDKNLDIKKLKAAFFKLVEENTVFRTIFKESEDDLELYQEILPMDKCFIDVKVESFNNTNIQKLELKEFKHAKFDLFNEIPLRVKILETQNSFVILLVVHHAFSDATTTMLMEKEMSRLYQGKEKRIISSVRPMSYQEYSIKQKSKEFKENLEALTLEYLENYNSIFKLPPAKFESIFKTCNFTQLCETFKFRLSLSKSKYTPFTLITAAITKTFVPLFPEDSFLLLGFPFANRTMETSEIFGNFLNNLLLPLTSKDLNISLDELQLKLLELLKYGKIPFQYLCKSLRQKQATNSMNIQIYVNCRYDLENEAELDFDEIDATSTKIPILNGVFEDVTNYPIEIDLDELKSTKKTSTKNYEITVRISKAFLEANAAMEATQFWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZH37</accession>
    <name>A0A914ZH37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZH37"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9594.t1">
        <property type="protein sequence ID" value="PSU_v2.g9594.t1"/>
        <property type="gene ID" value="PSU_v2.g9594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9594.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18471" checksum="0C81186D1F3B3307" modified="2023-02-22" version="1">MVKINFNLSKLLIPPELIDFESAEEHERRGRELREKALTTLKINEQEFTQAERAQEAARIAADQANAKTTQALENQERGQQLLAEAGARLIEAGAKLQQEAAAIKREVPFNVHQQGEVRQTTCVSAAGVEAVAHAREVATFREIQPPQTTTTAIVGGTTSNQFQGQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHR8</accession>
    <name>A0A914ZHR8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="3">1.4.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZHR8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9850.t1">
        <property type="protein sequence ID" value="PSU_v2.g9850.t1"/>
        <property type="gene ID" value="PSU_v2.g9850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000100">
        <property type="entry name" value="Glutamate dehydrogenase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF13">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="779"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="741"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9850.t1"/>
        </source>
    </evidence>
    <sequence length="824" mass="91712" checksum="9EDC2ECA0A6EDEFA" modified="2023-02-22" version="1">MLSRLARGSQLFAARRGYSASVTLDPHDQINDLDKPMDEQLNPSFFKMVDYYFDKGASVIEPKLVEEITSQKMTKHEKKHYVRGILNTIKPVNKVLYITFPIRRDNGEYEIIEAWRAQHSEHRTPTKGGIRYSLDVCEDEVKALSALMTYKCAAVDVPFGGAKGGVKIDPRKYSEYEIEKITRRIAVEFSKKGFLGPGVDVPAPDMGTGEREMAWIADTYAQTIGHLDRDASACITGKPIVAGGIHGRVSATGRGVWKGLEVFINDEEYMSKIGLTTGFAGKTFIVQGFGNVGLHTMRYLNRDGAKCVGVQEWDCAIYNADGINPKDLEDYKIEHGTIKGFPGAKAFEPFKELMFEKCDILIPAACEKEIHKGNAHRVQAKIIAEAANGPTTPAADKILLERGDCLIIPDMFVNSGGVTVSFFEWLKNLNHVSFGRLTFKYERDSNYHLLGSVQESVERALGKEIPIQPSDSFKKRIAGASEKDIVHSGLEYTMQRSANAIIKTAHKYNLGLDLRTAAYANSIEKMAQVFFDSDTPNVYDLNLTANEILAKHVSNEQVTEFGLFFNGRKVLNDQKLSDIKGLTAGKILRILNRKNSRVQAPSNLREQVVELDKRFEKFNALDDRNMTACLYNKNYIKQLIKDFPIILEEPILLNVLTDYSLLSAMLHEEVGFIQQHPSYVPILQKILADALPAAPEMMNLLRSALNPRRQRNVAENVPAVPTPARPLFTNQMLHDALRTANPFENSSSNGPAQSSTAEPPQPQAEAGLPEAAVPPPSVPVNRFAIQLAQLRDMGFTDDDTNIVILDSVDGNVEQATNLLFAMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XST1</accession>
    <name>A0A914XST1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XST1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11029.t1">
        <property type="protein sequence ID" value="PSU_v2.g11029.t1"/>
        <property type="gene ID" value="PSU_v2.g11029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11029.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8997" checksum="0A5DB90ABCC94667" modified="2023-02-22" version="1">MEEKEFYFFWEFIIFTTVFNILARILNRCNFYLIGAFGFIILSLTQCICFIFFIKNSINDFSNQSENGKLLQNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSW9</accession>
    <name>A0A914XSW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSW9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10367.t1">
        <property type="protein sequence ID" value="PSU_v2.g10367.t1"/>
        <property type="gene ID" value="PSU_v2.g10367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10367.t1"/>
        </source>
    </evidence>
    <sequence length="655" mass="73317" checksum="D6664A8E7094A9B0" modified="2023-02-22" version="1">MKQITHSAEAYHKLKAIIDIANQHLQQMNHQKHKVPADLMADVEIFLTDSPGWFLSVIEGRDKNIKGLERELDDLSDVCNNIIAERNELRLKLEEPMGLSLGNQKKLRSLGVENLSDLINNYRKLQIQVSGPTERRFNPADSDSSLDQKEEWQMQQQLLPKVLQQGGFHSCSANMGTKGSSSGDHIPIPMPDKFTGKTRIDLERYFRYFDQAVNSRGFSDSAKAIMVGNYVPTLQYTHDKLLRKNTSYDGVKAGLLNSLGTDSSVATYTLRTSLDRVKKSDDKLYRNILEEVERQVTQAFNGDDDQGDAELKKILIRLTQEDSNPIFGSTIIPHLNEEYTRLKELVLGVEEALLIKKNNDLLVKQESETSSSNANRPYPSDPNRYHSSRPFDYKRPYGGNERDHDKITVQSSRTEVECSPNNEPVGQRAYVCYKCKKPGHYSNDCPESNAQGVRHVKHIDDLGMNGVAIVDNVGQSGQDLKLFGKKAMLDIFLDTVKVNAMLDSGACASVISESAIGKILRQRPKDVRQITEEDPTTFMHKRLVNANGSALNVVNCIRMPIAWGSYPSKIVKFFVVSGLQQDVLIGTNVLQNDICWIEALEIALGYGAQDADSDNGRNGMGIGYIAPPNGRSGTCSSREKFNTVSLYRDNLKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT94</accession>
    <name>A0A914XT94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT94"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11183.t1">
        <property type="protein sequence ID" value="PSU_v2.g11183.t1"/>
        <property type="gene ID" value="PSU_v2.g11183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11183.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15584" checksum="0D0FB45DC0997D88" modified="2023-02-22" version="1">MRWCCGGLSEARGAIATANGGSNGRRQQLTIQGDQVVLDATTAAALNNLHQGTSSSAKDEPRPSTSSEAYQFSSTSDCYGGGRYKSSSTHPVSATCYSGGQRRNSEGKIIFDNIQESALSPRNAALIMDKYGPMLLRPCKSVSYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTZ6</accession>
    <name>A0A914XTZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTZ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10001.t1">
        <property type="protein sequence ID" value="PSU_v2.g10001.t1"/>
        <property type="gene ID" value="PSU_v2.g10001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17678">
        <property type="entry name" value="RUN2_DENND5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047278">
        <property type="entry name" value="DEN5A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070:SF1">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="83"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="4">
        <location>
            <begin position="307"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10001.t1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52713" checksum="08051DE0CFE1D1FE" modified="2023-02-22" version="1">MEMSEIKTDIGCARAFVRLSLERKLLHKHLKTIFSNEHLLQKLYKRYAFLRSEEEREQFLFHILSLNAVDFSCFTHTFIATKMQYEVMVVAGIDRFASASIWIMITGSLGNTSVINLPVNSLQFTFDHKNLGVLSTLRIGHTLHQKSSNPTKWYLDYIIVRNNITAQTFRFNCGRWFGRGVDDGALERLLVAEVLPRESPKSDGTSSTTNPQQSTLSIFGGLISRPESPISGIFTGGSLASQKAQSVLHYSTQSLARRRRSPSVTRNPDSDGNNPRISELHHQLGVAVNALMKHFLAEQNYGGAQLTPLLCGENGLVSVLERVFSLGRKEGLYSLFQKQYPWDYVEAVFNWFANFFRHGESNRISKEQRSLIIFAYQLVRKIKDNNAVGKEGKFHVFILLTLRDHILSSLLPLMVWTPLTTNMYHEDAFLRQSNHTSYLSKLIASLNEFNFTLEKSLTYGIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU86</accession>
    <name>A0A914XU86_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914XU86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1053.t1">
        <property type="protein sequence ID" value="PSU_v2.g1053.t1"/>
        <property type="gene ID" value="PSU_v2.g1053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000153">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1053.t1"/>
        </source>
    </evidence>
    <sequence length="847" mass="96879" checksum="46BEFD61C6F8D2E0" modified="2023-02-22" version="1">MTDADRRKQISVRGIAQVENVANIKKAFNRHLHFSLIKDRNVATPRDYYFALADTVRDHLVSRWIRTQQYYYEHDPKRVYYLSLEFYMGRTLTNTMLNLGMQATVDEALYQLGLNIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGIPAYGYGLRYEYGIFKQIIKDGWQIEEPDDWLRFGNPWEKARPEYMLPVNFYGRVEKDSDGKNKWVDTHVVFAMPYDTPVPGFRNNVVNTLRLWSAKAENHFHLKFFNDGDYVQAVMDRNLTENITRVLYPNDNVFVGKELRLKQQYFLVAATLQDIIRRFKSSKYGVREAVRIDFETFPDKVAIQLNDTHPSIGIPELIRLLVDIEGLTFEQAFDIGVRSFGYTNHTLLPEALERWPVSMLNSLLPRHLEIIYEINARFLTQVASKYPGDLDRLRRMSIVEEADDHGEKRINMAHLCIVGSHAVNGVAALHSKLLQIDTFKDFAEYYQGRFQNKTNGITPRRWLLLCNPSLADVIIERIGEDWVTNLDLLQQLKKLDENAGFLDTLGRIKNDNKVRVAQFIKEEFDIDIDPSSIYDVHVKRIHEYKRQLLNALHVITLYNRIKADPAAKIVPRTVMFGGKAAPGYHMAKQIIKLINAVANVVNNDPIVADKLKIVYLENYRVSMAEKIIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTLDGANVEMMEECGNENIFIFGMTVEDVTELQNRGYNANDFISKNSELAQCIDQIDSGYFTQDQPDLLKDLANSIRHHDRFLVCADYESYIKKQEEVSQAFLDRQKWIKMCLHNIASCGKFSTDRTISEYATQIWGVEPNGIRLAAPYEGAEGTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV01</accession>
    <name>A0A914XV01_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XV01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11768.t1">
        <property type="protein sequence ID" value="PSU_v2.g11768.t1"/>
        <property type="gene ID" value="PSU_v2.g11768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11768.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20895" checksum="3926DDB6B5BF29A8" modified="2023-02-22" version="1">MIYDKKYHSSFNDTDYPSIAQMMSLPFKNFYDVKNTNKDIIDEALGFYQQAMDADTYLIHGDADRTLIYLFLFITECCKCCLYAKDALTAWERLRLLVDEKILPIPGDVGFPFNAYYGRPKNAREKYFLRSYLMQLEQECIERFFMIVYKNTDDPREDWLSFGKQTFLGHHFKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV87</accession>
    <name>A0A914XV87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thyroglobulin type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XV87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10884.t1">
        <property type="protein sequence ID" value="PSU_v2.g10884.t1"/>
        <property type="gene ID" value="PSU_v2.g10884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF30">
        <property type="entry name" value="FI05255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Thyroglobulin type-1" evidence="9">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10884.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33420" checksum="AB68ABA43443FDF5" modified="2023-02-22" version="1">MYLCVSNVLPEPNDDNSLPIYELPTKLPSLFSQHSTVSPFGSDEDSSALFLETISKKSDPTSSSPSESDGEIIEKPNCRIEREKVISSIDPQYLDTIFIPKCTGESDKFYIEIQCHQKPTRKYCWCVHPITGSPSGNSLVETIDECKKSSSSSKKKLSSQKQLGSIKGCVPEKELLFYRKLFGLLAKEMREKSPLLPNGPKRRKPQVAKWKFAMLDSNGNNEVERSEWKEFRATLRDLKNVRKCGRNFIRFCDINKDGRINRREWMRCTVHAYRHAKSTKPNPFLTMLKSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW08</accession>
    <name>A0A914XW08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11418.t1">
        <property type="protein sequence ID" value="PSU_v2.g11418.t1"/>
        <property type="gene ID" value="PSU_v2.g11418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF248">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11418.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22403" checksum="DE6941575ED04D50" modified="2023-02-22" version="1">MLSTSFILALSYTIYAVFCLWPRQPSYNEKAKLFENDIFYYKGIPNFVTADIREWPLFGIYIYCYILMVVSYVIVIWTSYKVWKYLKVMRSHLSISAHELNSQVTKTLIMQALTPLLICLLPILVTVTMVFLRANIGGIGLVLSIFYSWIPIGNALVTIIAVKTYRRAIISPFSCFTKRNQVVSSTGGGATFYNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW22</accession>
    <name>A0A914XW22_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 16">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 16"/>
    <dbReference type="AlphaFoldDB" id="A0A914XW22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10724.t1">
        <property type="protein sequence ID" value="PSU_v2.g10724.t1"/>
        <property type="gene ID" value="PSU_v2.g10724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10724.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20316" checksum="B601AE02D7F2420A" modified="2023-02-22" version="1">MGASICYFLSAFLDAFDGYAARLYNQGTRFGAMLDQLTDRLAFVALLMTLCTFYPRCIFLFQLVVIIDIASHWLHLHATDLTGKDTHKDSKNPILHYYYTSRPFLFFMCFGNEAFFSLLYINAFWSGPSILGIHFIPFLAFIFFWVALVKQLISIVHLVVASQTVAEFDVARHSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXH7</accession>
    <name>A0A914XXH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXH7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11228.t1">
        <property type="protein sequence ID" value="PSU_v2.g11228.t1"/>
        <property type="gene ID" value="PSU_v2.g11228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001346">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11228.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14433" checksum="E107CFAA2FDA2A03" modified="2023-02-22" version="1">MAPESLRDRKIFNVKTDVWSLGVVIWELMTRAAAPYGDISNAEIRQYLEAGKRLPQPTHCPDIIYGIMLSCWRTHPNDRPDFSWLAQHLQDILRKQVGISRRFGNRTDPFFLPVPPGGIYTNYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXI0</accession>
    <name>A0A914XXI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXI0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10455.t1">
        <property type="protein sequence ID" value="PSU_v2.g10455.t1"/>
        <property type="gene ID" value="PSU_v2.g10455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10455.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8540" checksum="9F1C0C668B3E8BD2" modified="2023-02-22" version="1">MDFLLDFFVDLTLTNDDFFKNLQVLANILFHSKIPKGSVERRSLLLFCINHRRHKRGIPVLIDDQPTPMAPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXJ7</accession>
    <name>A0A914XXJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXJ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11679.t1">
        <property type="protein sequence ID" value="PSU_v2.g11679.t1"/>
        <property type="gene ID" value="PSU_v2.g11679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037471567" evidence="3">
        <location>
            <begin position="18"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11679.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42071" checksum="40A4ADCB841A4DD4" modified="2023-02-22" version="1">MFHLVFLFGFIVAAASADTLQHLQILYRHGDRAPEGTYKNDPYQESAWPVAWSELTDTGMQQHFIQGSKIQQKYMFNIPYLPQDYKSKDIRVQSTDVDRTLASAYSHLVGLYSASNGTYPSIQNWPTKFSPIPVHTIDKKTDHILNADPSSCLRMDELEAEQVAHGKFIQYLTAQLPLLLEISEKSGDKITDVAGLRNFYDAITIERIHNMTLPAWITDSIFNQVKTIVETCEDYIFGSAGFGKAENSELIKLKGGLLLQEMIKNMDNNGGVKLYMYSAHDTTVAAFLRTLEAKEGIIGSVSPDFAATVVVELWLAGDNTQYVKLWYSDNANTDFRDVTHTIGNCGGGNKCTYNAFKERSQKYLPGDIEKACDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXY4</accession>
    <name>A0A914XXY4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L35</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12061.t1">
        <property type="protein sequence ID" value="PSU_v2.g12061.t1"/>
        <property type="gene ID" value="PSU_v2.g12061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12061.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14659" checksum="C9309083A55D1A5C" modified="2023-02-22" version="1">MSAARVKTHELRLKKKEDLAKTLDEQKTELASLRVAKVTGSQASKLSKIRVVRKNIARVLTVMNQLQKLNLRKYYKGRKYKPLDLRCKKTRAMRRALTKQELSLRTPKQLHRMRKFAPRVYALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYJ4</accession>
    <name>A0A914XYJ4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914XYJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10763.t1">
        <property type="protein sequence ID" value="PSU_v2.g10763.t1"/>
        <property type="gene ID" value="PSU_v2.g10763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10763.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19327" checksum="EAE191DDAAE11927" modified="2023-02-22" version="1">MAMTMDPGVHPLASTAEEAMMDDFRSPLYKNVEINGITVRMKWCVTCKFYRPPRSSHCSVCNRCIDCFDHHCPWVHNCVGRRNYPLTFTLTTRNFGNEILSRPNLCAIVLMAICALLAVPIIGLTGFHVVLVLRARTTNEQVTGKFRSGFNPFTTGCCSNSKRALCTSQYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYT2</accession>
    <name>A0A914XYT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYT2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13102.t1">
        <property type="protein sequence ID" value="PSU_v2.g13102.t1"/>
        <property type="gene ID" value="PSU_v2.g13102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13102.t1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35191" checksum="9D675333E82951F9" modified="2023-02-22" version="1">MSSIRKALPPTKNKLRRLITEAKEIQVVMDPSDKNGIKGTLEKFTMIKMDIRQSLRTINASVSQWEDLIEDLTGQEKTTEQDLLDVWLTSGPDADNPTGLDQLIADALQSLGELQYNIEEMDAILHPRAPAVIGSSQFGNNSIAQSPAAAVGTTTKTEVETTEQVNSTPPELGNHCQQLKHSSIATGSTPATPCSVKLPDLKPYYFDGNILNWLPFEDYFLTHIDAQPLADVTKLAYLLDSLHGPTKKAVQGTSCSASNYRVIWNKLKARFGDVSIISTTLQLLLSEISPCSDNAKTFQMRQVFDLMENYLNQLEILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ09</accession>
    <name>A0A914XZ09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor Dp-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZ09"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12452.t1">
        <property type="protein sequence ID" value="PSU_v2.g12452.t1"/>
        <property type="gene ID" value="PSU_v2.g12452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000047">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="10">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="9">
        <location>
            <begin position="201"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12452.t1"/>
        </source>
    </evidence>
    <sequence length="497" mass="56134" checksum="01C051039924263B" modified="2023-02-22" version="1">MQRQTRSPGRPSSSSVGNNHSGVEGSSSTITVLRPYVPGAAPAVARRVLVPTHSRSITGSIATPTYRYGPSKVSAVSRLDQISDEKDGTKKNNGIPFSTESANRMYRSNDKSRGLRHFSTKVCEKVKEKGRTNYNEVADELVAEYFDSLATPPQSVEKQQYDMKNIRRRVYDALNVLMAMNIIEKEKKEIRWVGLPTSSHQECRRYEDEKVQRQESIRKKTEQLQELVIQLVAYKTLVQRNRENERVDGRPADSKIIYLPFIVINTSRETVVDCSIASDKTEFLFHFDQPFEIHDDIEILKRLGLSYGLDKSDVPPEYRQHIKECLPNALKNYADEIIDGNLTTNLPPSQPSPQQPQQQQPKPVMQVTSPIDRKVPIVRPINPGVRAIVPTSRGAARTVIRPRGVGATYHRAPPLRSSNQPYAIPPSSASVYRNVAQQHYALPPNRVNAGQRFVQRTAPRIQTSYTTNIHDLNPNDQGALHYEDDVLYGDEEYGYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0C8</accession>
    <name>A0A914Y0C8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y0C8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13659.t1">
        <property type="protein sequence ID" value="PSU_v2.g13659.t1"/>
        <property type="gene ID" value="PSU_v2.g13659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17403">
        <property type="entry name" value="MFS_SLCO4_OATP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF100">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="70"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="471"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13659.t1"/>
        </source>
    </evidence>
    <sequence length="748" mass="81734" checksum="DCCA0E96C1D02427" modified="2023-02-22" version="1">MTIETDNDLPSGSKHYDQRFYPPSSISTGSPPSSRRTSSSGYGSEDDPLLCGFGGCTPSWLQRFHNAKWLLIMLGICAFVQSLVVNSIFPVGLSTLEKRFHMTSTQTGIISSWYDFAVLIAVFPVCHWGNTGHKGRWIGLGTFVMGLGSFVCALPHYIVPPYVVGQSQNASDYGQCTNRVLDDVCVGATDEEASYLNPYFLIFLLGQTLHGIGATPLFSIGTAYIDENVSQKASPVYLAIHAVVTSIGPVIGLFIGGYFLTIYTDFDRVDMSTVPLKDSSDPRWVGAWWLGFLVCAVAALINAFPILMFARELPEAKKHRMKDVNQCHAVSQVDDSDEILKGNVKNLPRAIWNILRNPTFVMCIVLGIFESIVINGFAAFMPKILETILSTTPTKASYLSSLVIFAAAAGVMLGGAAIRQMNLQVGGMLKMILLCHVIALVLITSFLIQCPARNFVGINVGYENTTAESFAGLKAQCNVDCDCKSEWNPVCDHETGNTYYSACYAGCRTKISNPNGDEWTDCGCVEFDSRDNFLSLISTPLSTNGSNIVSGFCTKECGWPMWLFLVLLFFSVVASFASGIPSQQIMLRVIPFQQRTLGIGVHWTFLRLLGFIPGGVLFGLMIDTTCLKWKESKCGSKQSCLVYDPNLLSWTIMGVAVVCKLVSILATIIGYMTYRPNDLDSAVSVQTTDSRGPLSLTVNDDRQPAEIARQSIKKGSTNNKIIALNQRVGNHITDDVSDEMTAGSPTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0S4</accession>
    <name>A0A914Y0S4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-eEF1A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0S4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13056.t1">
        <property type="protein sequence ID" value="PSU_v2.g13056.t1"/>
        <property type="gene ID" value="PSU_v2.g13056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP-eEF1A C-terminal" evidence="3">
        <location>
            <begin position="246"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13056.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38823" checksum="F3FEFE29033E2004" modified="2023-02-22" version="1">MFNIFAIETDTKIVKLYDTVTIGNSKLNQYYASTFADFGIIVCDSDYYKNGNHYDRRLKSLAKLILANKFLHTVVLLNINDGQALQEIYFNDIKATIINIFKNQGFNPNSDITVIPCISNKVDGFLKSRPKTNTYQWYKGPTVVECLDNFSKIWDESVQKGVNKITIDKQDELNDVIGKIEYGEIYVGDPLMKGNQELTVKEIIVNNSVLPASSAGTIVKLKLNQCTDIPHGSILSFPECTQSNVFNAYINTMNTTISALSNDYWIFINAEKQKITITNFQTHSVEDDRYNDVEIIKKYSRCYVRVISNRDVCINSSQDFPRLSRFLLLEKNHICGYGNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1A2</accession>
    <name>A0A914Y1A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-guanine(15) transglycosylase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1A2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13229.t1">
        <property type="protein sequence ID" value="PSU_v2.g13229.t1"/>
        <property type="gene ID" value="PSU_v2.g13229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="1">
        <location>
            <begin position="27"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13229.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43701" checksum="A8D647B4E30F4832" modified="2023-02-22" version="1">MPIKLSVERQTNVGRLCKITEWGTFSDETDIQTPAYLTYTRFGHIPHITWDVAENELSLKQKQIYQLTLASFFEALEAIEKTATYEGVASFCCMPLNSIRHLSLHDPLAKIPEGFNNNKSMAIWSGKAGRRSIEPENFIKILKTCKPHSFTTLWDYDTPFNVQKKRHGKSFYRSSEWDMALFEKNHTIFEEPGFLPLAGGISKESRIAFAKYFGPKPYANGFLIDLYHFSHGENIQNKSEFEADIVSDLISDVTLLIQQDVPRLVEGAFDPYQILCLVKNGCDLFDSSYTVLLAEKGIGFNVAEDYAKTGTFSVVDFTEEKNKTDMTPLCSRCSCYTCKTFKRAYLHHLIACKEMLGFTLLIIHNMTEFDRMFEMIRAHLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1K0</accession>
    <name>A0A914Y1K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF302 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1K0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13331.t1">
        <property type="protein sequence ID" value="PSU_v2.g13331.t1"/>
        <property type="gene ID" value="PSU_v2.g13331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13331.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="18077" checksum="A6FC5FAACC502DA3" modified="2023-02-22" version="1">MQYCIILIKYRISSLPLFIDENVENQLYHLRIQGPLHQQLLKLDEFIQSCECQFRDQLFFIKNDKGKEFVVILSVKLGELKTCENLLPFMICPVLKIEGVTSEAIYYRDGWECNILWPKMSPKEKFDFAKWLHEKLMDISERYYLSPIVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y315</accession>
    <name>A0A914Y315_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y315"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13840.t1">
        <property type="protein sequence ID" value="PSU_v2.g13840.t1"/>
        <property type="gene ID" value="PSU_v2.g13840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13840.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="25857" checksum="53921E25164056D6" modified="2023-02-22" version="1">MTPIFLPQPLPPNQPSYFPPPLIPPKPKPSNSSPNGPPPVIRPRNDSLFPKTTTTTSNYNAQNHPQQQYSNTSITPPIIPLRPYPGTTSTNTNGTQSYYSRSYSSQASYQFGFGRQSGFGSTSTNSSSSTQSNTATNQWNTLPPKSVTTYSQSQQYITSNSAPTTPTIPPNTPNSNPPTTKTEPVRKGVGQFNVSVNKAMDGIDRIITKASNALSSPRNKNTTPNQNQPQQNTAAVKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3K5</accession>
    <name>A0A914Y3K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3K5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12344.t1">
        <property type="protein sequence ID" value="PSU_v2.g12344.t1"/>
        <property type="gene ID" value="PSU_v2.g12344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040264">
        <property type="entry name" value="T15H9.4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31327">
        <property type="entry name" value="SPERM MEIOSIS PDZ DOMAIN CONTAINING PROTEINS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12344.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13741" checksum="1452294754575A57" modified="2023-02-22" version="1">MIAGDRLVAVDGEAAKDREQTKKIILKGFTKRKKCTFLIERPQTSEAKLWAKTAILSSSTRTSSTAPREKHKWALMAAQQRQAARLLAAKEARTPPQNETGSARSAISFNALSISGKNNSQQKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4G8</accession>
    <name>A0A914Y4G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the paired homeobox family. Unc-4 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4G8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14117.t1">
        <property type="protein sequence ID" value="PSU_v2.g14117.t1"/>
        <property type="gene ID" value="PSU_v2.g14117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14117.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14523" checksum="2C99B95D8D568241" modified="2023-02-22" version="1">MDINTILLEYWKMQEKMMGTAAELLPSLAVIAAANYGQQNDGASDESGEEGISCPVSPSPTETSMDESGNAASKDTTSKKASNKRRRTRTNFSGWQLEELENAFESSHYPDVFMREALALRLDLLESRVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Y5</accession>
    <name>A0A914Y4Y5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ku70/Ku80 N-terminal alpha/beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Y5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12767.t1">
        <property type="protein sequence ID" value="PSU_v2.g12767.t1"/>
        <property type="gene ID" value="PSU_v2.g12767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku70/Ku80 N-terminal alpha/beta" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12767.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18152" checksum="EA5550756D667E70" modified="2023-02-22" version="1">MESTNAKIQPDSGRQGTIFCFDCSEYMFEVNEDDKEKRTHMLIALKAMRSEMNHKCLSADLREMVSIIFFNTAKTNIDAEALDNIFVYRNMVEYDENKFMKGLGADTVKQVDELIKDEKKRKEFFEVTLGGSGQCDYSQLVWLFQRNFQYEQVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y596</accession>
    <name>A0A914Y596_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y596"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12867.t1">
        <property type="protein sequence ID" value="PSU_v2.g12867.t1"/>
        <property type="gene ID" value="PSU_v2.g12867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032406">
        <property type="entry name" value="CLZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16526">
        <property type="entry name" value="CLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="315"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12867.t1"/>
        </source>
    </evidence>
    <sequence length="545" mass="62926" checksum="FE91EF7F90173738" modified="2023-02-22" version="1">MAYVYNLIVVIARAVFYDIAAGYLWFPWMLLDVFFDFIYFLDMFIRSRTGFLEQGLLVRDVGRTTKAYIKSTQFRLDICSFFPVDLILMIIFRRPQPIYRMNRLLRRDRIQKFMEQTETRSSMPNIFRVAAVVWYICVIIHWNACFYFLISESVGLGSDSWVYGSKNIQSMPPGVSVSDTLARRYIYSFYWSTLILTTIGEVPWPQQNIEFVFVTLDLMCGVLIFATIVGNVGTMISNMSAARAEFQTKMDSIKQFMELRRVSKALEVRVIKWFDYLWDNKQGLSDQQVLEVLPDKLQAEIAMHVHFETLRKVRIFQDCEAGLLAELVLKLKLQVFSPGDFICRKGDIGREMYIVKRGKLQVVADDGITVYATLIEGAVFGELSILNIAGSKNGNRRTANVRSVGYTDLFVLNKTDLWTALREYPEARKMLIQKGREILRKDNLLDENAPEENKTAEEIADELQTNVRLLQQKIARLVAERISTDEKLKTRIGYLESKLSKYEVITESSTEESDDDDDQDNSNDEENNDDGKIVEKIIVPSKKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5K8</accession>
    <name>A0A914Y5K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DksA C4-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5K8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14524.t1">
        <property type="protein sequence ID" value="PSU_v2.g14524.t1"/>
        <property type="gene ID" value="PSU_v2.g14524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900378">
        <property type="term" value="P:positive regulation of secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.910:FF:000002">
        <property type="entry name" value="DksA/TraR family C4-type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.910">
        <property type="entry name" value="DksA, coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008243">
        <property type="entry name" value="PRK11019.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38777:SF1">
        <property type="entry name" value="DNAK SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38777">
        <property type="entry name" value="FELS-2 PROPHAGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger DksA/TraR C4-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14524.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10640" checksum="75A3163D041851F5" modified="2023-02-22" version="1">MASGWANDDAVNEQINSTIEDAIARARGEIPRGESLDECEECGAPIPQARREAIPGVRLCIHCQQEKDLQNQLIQDIIAEVRKTASYVNYNWRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y689</accession>
    <name>A0A914Y689_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y689"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14764.t1">
        <property type="protein sequence ID" value="PSU_v2.g14764.t1"/>
        <property type="gene ID" value="PSU_v2.g14764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14764.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9306" checksum="7D9A33F7216D699D" modified="2023-02-22" version="1">MAENIPSEDWRDALNQEGAPFGHHKHGINRPAHEHVCMRSEPFERQPPTFALFKLTSISTNPKWNGFKAFVTKKSKICFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6B6</accession>
    <name>A0A914Y6B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6B6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14993.t1">
        <property type="protein sequence ID" value="PSU_v2.g14993.t1"/>
        <property type="gene ID" value="PSU_v2.g14993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14993.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22970" checksum="237ACF8FECD94530" modified="2023-02-22" version="1">MDNDYGDKAVDSFDDVKTNKADDIYGIYVAPHGLVGTDHGFVHIGSLTNDESALQHKEESQQLDDTVAGISQADARASAIMEIRDQAQGIVDSAAEAYRKLKSAVEVTNADLKSINHVKNMISADLMSGIEVFLTDSPGWFLSVLHERDKSIEALCQQLEQREDDCTNFIRDRDELQIKLEESSVGLSFGSSLRLGGNFSIKIGSKTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7H8</accession>
    <name>A0A914Y7H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7H8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15229.t1">
        <property type="protein sequence ID" value="PSU_v2.g15229.t1"/>
        <property type="gene ID" value="PSU_v2.g15229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15229.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15443" checksum="3A019B41D00A85DC" modified="2023-02-22" version="1">MIASCFGHVSIIDKLIQYAKQRSKFSHQKTFADIVGLQMTDESGFTALHFAVYYAQEDAVRYLLNVHANPNIPDLDGMTPTLLACTDEHRKKCLKDLINANGKLQHRNKNGQSGFDLQQNLSKTEETKKSQKYGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7R1</accession>
    <name>A0A914Y7R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7R1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1624.t1">
        <property type="protein sequence ID" value="PSU_v2.g1624.t1"/>
        <property type="gene ID" value="PSU_v2.g1624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1624.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41810" checksum="0C21960CD1B8E7DA" modified="2023-02-22" version="1">MDNIAHLWKVAEDSRRLNQSSNPECRPYRNPNEMLQRWRLRSMESGMNNKMEDFERMLPKTTILSSDIHSCKLSFKELKSIKLCDMEVPMVHNERYLVCQVIAMPSLYVGVTILIQDLNGDVEEVAIYNFSYNFNDLDLLSPGTILIIKEPWLRYGSHDKTPSLRIDSPSDIIFVDPTDHKLLCKIGAKQWFVSMSEDAEVWKQEANECFKKKDYKKALFLYDRAIRYNPDLPVLYLNKSITCLQTGAFYMAYESAKFALEKGGDREKALYRMGQAAYGMREWQKAISHFEEVLKEFPKNSSASEHLKRASARLSEQRTGKFDFKAMFLESKKEKAELDVSDYSGPIEIAEIPGKGTVFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8E3</accession>
    <name>A0A914Y8E3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8E3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13862.t1">
        <property type="protein sequence ID" value="PSU_v2.g13862.t1"/>
        <property type="gene ID" value="PSU_v2.g13862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037041898" evidence="1">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13862.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="17502" checksum="8D1768A3F0BF642A" modified="2023-02-22" version="1">MARFIIFAVVAFCIEAALAQYGSHGGISSSPYGGGLSSFGSSGLGGLGGLGSGLYDDGLYGSASSLGGYGSTGSLGGYGLGPLYGSSFPSRGNTFPLGGLGSQYGGSSLGSPYGSAGLGSPYGSSGLGGLYGGSSNGLYGGSSSLYSGGLSPYGSLSSPLGGSRLSGIGSGSIYDSFPYANRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8Y6</accession>
    <name>A0A914Y8Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8Y6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15218.t1">
        <property type="protein sequence ID" value="PSU_v2.g15218.t1"/>
        <property type="gene ID" value="PSU_v2.g15218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15218.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15089" checksum="974D633D2580BAF5" modified="2023-02-22" version="1">MDFSENPQEGKSTVFYARFREENVYEEFKKLFNDIAEGTHTINTDVAETTSSVITSKSPSHTPTATVPSLPYIGDSHNPSVDADEDEEEEYDEDYGEEENYDEESEVLLESDCKVTLGEAYKSPLSKNVCFCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9N2</accession>
    <name>A0A914Y9N2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9N2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16144.t1">
        <property type="protein sequence ID" value="PSU_v2.g16144.t1"/>
        <property type="gene ID" value="PSU_v2.g16144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16144.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29528" checksum="F552800C5949250A" modified="2023-02-22" version="1">MDRLRKNYFVILCHLEQIFDAEEFRRDRDTKLLAKGHHKELATLETYLYTLFILDVLEPLKILSNKLQTHLYSITQLQDDLNGAVESLEKMEEDYGHHINQFLRFAECEDAVGDECKSLILEGKEGNVFIKMETFFENSQPKQKHIFTRRRKRLNFDELKNIIIPKLIHHLKTSFPEDKEFVEHISSLNPSNLPTGVSMLSEYSKKIEKIAPRFGGNSARIVNEFIDIMRYLISNDYQTYMANIYLSTPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9R8</accession>
    <name>A0A914Y9R8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y9R8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14277.t1">
        <property type="protein sequence ID" value="PSU_v2.g14277.t1"/>
        <property type="gene ID" value="PSU_v2.g14277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14277.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16038" checksum="0532F7B16DB98D4E" modified="2023-02-22" version="1">MKIVLVRFTVSKMATEKKFRCRKCRTDLFYDIHVQKHLRRNDESNELCAFNFLVAPLKWMSLDEYQGKISCPKCNEKLGQYIWGGRQCMGEVGLRCGRHIAPWIHIQKAKTDESSLSGVEVHAQLPPSMTVIPAAEAPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAG3</accession>
    <name>A0A914YAG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Right handed beta helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16420.t1">
        <property type="protein sequence ID" value="PSU_v2.g16420.t1"/>
        <property type="gene ID" value="PSU_v2.g16420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF20">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="3">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16420.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10932" checksum="42BBBB77ABA8FBE3" modified="2023-02-22" version="1">MVGAAVCVKKAMTCPKIKHCLIADCENVGIFITDNASGHYEDCEIARNNLAGVWVKNQANPFFRRCHIHHGRDVGIFTFEYGLGLFLLFLNWEHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAQ6</accession>
    <name>A0A914YAQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17288.t1">
        <property type="protein sequence ID" value="PSU_v2.g17288.t1"/>
        <property type="gene ID" value="PSU_v2.g17288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17288.t1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47601" checksum="8E3595D871CF0FAF" modified="2023-02-22" version="1">MEFQELLNIKTDTPFELELEEEGTQTILEKVSEFLVIDSANIASTSASSNNYLLANNINNFNTNPPDSWVLSTGSNQEDFTFVCLWKNCFEYIPNSWNLENHLEEHFRNEFSVKNELSTEQLKCPIFGCEINLESSKHVYCHLRSHYFQAEKQKVGLEYYRKLFPSLIPCGFERTSYLPLEGDPWVCGWKDCKTVFDDLKQFVSHVSSHLNGYGDDERDESGMFPCCWISGIEHKQCEKRFSQKAFLKVHLKSHSGNRVCACPYCGTFLANTTKLCDHVHRRQPTSDAPLICALCQKKFSTNRLLKIHCRKHVKSVKCAICDVVMDCASAVAKHMKIVHAKIKNEKCPECNQTFGLKTDLQKHIAAIHQIEPQFACKFCDDRFRWEKQLRAHEKTHSKDFVATPYLCHKFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB60</accession>
    <name>A0A914YB60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription initiation factor TFIID component TAF4 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YB60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14725.t1">
        <property type="protein sequence ID" value="PSU_v2.g14725.t1"/>
        <property type="gene ID" value="PSU_v2.g14725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="7">
        <location>
            <begin position="297"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14725.t1"/>
        </source>
    </evidence>
    <sequence length="465" mass="51846" checksum="D8D9D3C16844738E" modified="2023-02-22" version="1">MQILHQNVHGVRDTLANFLELNIYAVRKDIQEKKIAMGEVVQFQLVKTEAYNFQTPSSSSSSQQLNYSTSSPSLDASTVSTSQQNYVKSEPISAGSSQEQGASPNLIMPINTITTSVTYQMVKMEPGSSRSSPILRTSSPHFQLLNKSHGSVGANEQHQHRASPLTLTRDTSIQMPMQQPKTSPLAATTAPNIEMQTLSFFDQHSQEPMETSQVPSPQETTFITPPESQPQHVQQQHPQSQVSPPLSQEAAIDDDTPLTELPHEIALQRSLIDPETFSALMQRKVPGITIESPAFLMISEFLETKIRKLIGDARLAAEHRSQQFRSNPNYIEAENPRAQLNAIERAEKAEKQRKIDRENERLLKNSKNDSNKFKELAKTIDEEILNRDANEAAMSALAGKKRTWQSRKADGISDSGGPAAKKAALARAKQISMKDLLFAFEKDSFAKDSIVYRKVLYGLYNENKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBC5</accession>
    <name>A0A914YBC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16580.t1">
        <property type="protein sequence ID" value="PSU_v2.g16580.t1"/>
        <property type="gene ID" value="PSU_v2.g16580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16580.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9209" checksum="04F0565D2B72AD72" modified="2023-02-22" version="1">MAGNFTSSIILNIFISFSVIILIFSLATEAAPTSDSANAYRILSNYMRQFNDPEQQLDSAGYIIFDDKSSIKRALGPRPLRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBD2</accession>
    <name>A0A914YBD2_9BILA</name>
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        <submittedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBD2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17515.t1">
        <property type="protein sequence ID" value="PSU_v2.g17515.t1"/>
        <property type="gene ID" value="PSU_v2.g17515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17515.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18775" checksum="D80938A013D6170C" modified="2023-02-22" version="1">MKRPDGGFSMNLKNAADDDLSEDETDDDDLLFKRFILPDNNYPTPQMMIAYRNDRKPSSSLRAIEDDDRHSHSDFSEITDTTSALINDTGKTPKIEPKALKRQEKAFHAVNEIAESEARYVAKLALLEKFRAEIEKEKLLEKKQMSGIFANTSKRDIGKLIIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCB4</accession>
    <name>A0A914YCB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16395.t1">
        <property type="protein sequence ID" value="PSU_v2.g16395.t1"/>
        <property type="gene ID" value="PSU_v2.g16395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF4">
        <property type="entry name" value="MOLO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16395.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38947" checksum="A4ACB97FB83A06CA" modified="2023-02-22" version="1">MIAGDWRRGARRVASPAVRSAFTIYCAMQPFLYNRIIFKCFIVFLHISFIYGGSSNHKDWSNSAYPDVRGPTYEICAKDLPKQGLLYICDPDRILNSTQLIRINEGLERLAIGTPCPCQRRSQCSSGGEIGSPFHGFVVSIAIVDNLQMTFHSPSEQQLTDRAESFCKTLEGRWALGDCGNSVIVFVWRHYKKVIIWPARLAERYVTVEERRVMLSKINDLIQADRWAEALSQITYELHQQLKGEPEARVDTGTLSLIVAVGVASLLTILITCCVCAFRCFGNLSNEDDGKSLNHFDNIRTQDFLRRGGSMRRSLSRSPKFPLRHKTPPPLTTLSFLNDSDTTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCN8</accession>
    <name>A0A914YCN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCN8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18003.t1">
        <property type="protein sequence ID" value="PSU_v2.g18003.t1"/>
        <property type="gene ID" value="PSU_v2.g18003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18003.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14104" checksum="A9A2416F52674431" modified="2023-02-22" version="1">MSQNGINYLTELASEALPHILVGFILPTIEVTSFKGEKFYVTKMDKPNISAKFIDKTGVNLTIEIPNLEVEGDATIDAFFTAESHMSVVVNNWTINLDVKIQRELDDDRNNITVSFILTDYGRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD79</accession>
    <name>A0A914YD79_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Decapping scavenger enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Scavenger mRNA-decapping enzyme DcpS</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YD79"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17396.t1">
        <property type="protein sequence ID" value="PSU_v2.g17396.t1"/>
        <property type="gene ID" value="PSU_v2.g17396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000006">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17396.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="28078" checksum="3B3DD9FA5B0F7B4B" modified="2023-02-22" version="1">MYRAAFRTVAINDIYGNYVLTLPDEYSGVKTTIVYPATEKHINKYKRQDIFVVYETAEDYKKITKPYFEGLNNVNWVYNILEGNAEQDRVQYHEKSEETGFLLAPDIKWDGTDVETLYYQAIVQRRDIGSVRELTKEHIPLLKAIRDKSTEIISEKFGLNTSQLKFYFHYHPTYFHLHVHIVNIKYDAPGCTMTCLQLQEAIDNLEIWPDFYQRATLTFVKKRDDPLLQKFVAAGRVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDZ3</accession>
    <name>A0A914YDZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDZ3"/>
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        <property type="protein sequence ID" value="PSU_v2.g16980.t1"/>
        <property type="gene ID" value="PSU_v2.g16980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16980.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10712" checksum="9C356AFE4D8C34DE" modified="2023-02-22" version="1">MPRKKVQRTPSLDALHQAEVKQKNAERMRKRRAEQTFEQREAENERQRKRRQQLSEAEKEEQNAAQIERTQAQRSHLSEAEKAEMKQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF15</accession>
    <name>A0A914YF15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g17347"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21515">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17347.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="13980" checksum="7814EAA6FBBE9111" modified="2023-02-22" version="1">MANIYILDVENTAFLVLGVLCASVTVTLQAAIALSFFMGCFKKKKGPPGAPAPGTPGATTSAQAPPASGAPAAAPPAKSGAAKPDEKKDEKPPEEKKDDKPAEEKKDAAKPAEEKKEDGGDNYEDVAVGGDAPPPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFB1</accession>
    <name>A0A914YFB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFB1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18007.t1">
        <property type="protein sequence ID" value="PSU_v2.g18007.t1"/>
        <property type="gene ID" value="PSU_v2.g18007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18007.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16905" checksum="885E7D601737669C" modified="2023-02-22" version="1">MGRLLNLMKHDHQEWDDLLMLDMKYLVIDEADYFLTGPKTKDILQFLENERLPPANQRQNLYFSPTLRTERLELLADEYSNVSKMVFLSSSLECNQRIKFIVENIPSANNKPEMLQNCVKKIIAENDGKCPRIMVFTNIKVSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFY9</accession>
    <name>A0A914YFY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18369.t1">
        <property type="protein sequence ID" value="PSU_v2.g18369.t1"/>
        <property type="gene ID" value="PSU_v2.g18369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18369.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12978" checksum="322A1871D31C8B88" modified="2023-02-22" version="1">MLHGIPLDSDLDKEAALLAKMDHPNIVRLYGICRWDTQIALVMEMMNLGDLKNYVRQRQPLSNNYSQFPAPLLTTELINIAGQIAAGLCYLNSQQIVHRDLGMSSDITVNKKAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGE3</accession>
    <name>A0A914YGE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17849.t1">
        <property type="protein sequence ID" value="PSU_v2.g17849.t1"/>
        <property type="gene ID" value="PSU_v2.g17849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17849.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12109" checksum="A70F8AD3359D4146" modified="2023-02-22" version="1">MSSLTLHSSSAPHMRRLLTNNYSNGLSSGSGSVCPRAAEAWNLLAIFIIGQMRFAYELERLLQVEIKRLGLTTYSSSSSSAAASELSPPSSPPPSLLPQQNQQQQNVQFSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGS9</accession>
    <name>A0A914YGS9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YGS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18530.t1">
        <property type="protein sequence ID" value="PSU_v2.g18530.t1"/>
        <property type="gene ID" value="PSU_v2.g18530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="84"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18530.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23896" checksum="704CD21621B7A5A2" modified="2023-02-22" version="1">MVMKDVMYSNTNLNRLNIYYSIEAFPHEKFRRKLFPKNFFNLSMSFRRDSTIWKPYDWFERIKPFEKNNPTLVWTSDDLNIALSKKTQLAVQFVSHCETHSLREKYVEKLERYANISTFGLCVNKTFESEKQELAFENAVCKDYVTEKFWRIKDLIVPVVIKRSLLKGIIENEYFIAADDFESPKDLANRLIYLSKNLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHI9</accession>
    <name>A0A914YHI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16770.t1">
        <property type="protein sequence ID" value="PSU_v2.g16770.t1"/>
        <property type="gene ID" value="PSU_v2.g16770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16770.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20277" checksum="DA170C9ABD7669F1" modified="2023-02-22" version="1">MAGYHSSTGSHHCPLCGNRFKYDYNLLYHYRKSCPYTKSFIEQDMRQQLDAQTLRKLVRSLASKDLRVEVRSDIPTNMRPKEEYGDTFVRREMMGGKPEVIRNLPQIPQNRPGMPEGKSCPLCGIVFYGLKVLERHVYTVHPEDHAYFDPEEGVMREIEEEEIVMESNVKRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI29</accession>
    <name>A0A914YI29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YI29"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18459.t1">
        <property type="protein sequence ID" value="PSU_v2.g18459.t1"/>
        <property type="gene ID" value="PSU_v2.g18459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040394">
        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123:SF7">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18459.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23822" checksum="A09FA596260F7FFC" modified="2023-02-22" version="1">MTFRLNKTSVEKDVHVSTARELVNRFGTGLEGNIAGVTFPKRSIVGSPQIVSQQLGSCSNLLDLISERQPKTLSDSNEDSVTFLDLPKEVISKILQKLPDHIGLIEMAKAHETFEALVDGQAKLWDRLSQFHFTQEQIDKHKTKEFTGRPLFFTLKKYYGLREHYADLIHICCHCKALFWKDHGHPCVSRDAPSVRVTPQQFVDMLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIL4</accession>
    <name>A0A914YIL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20182.t1">
        <property type="protein sequence ID" value="PSU_v2.g20182.t1"/>
        <property type="gene ID" value="PSU_v2.g20182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20182.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11561" checksum="D0AC7D4C033E03DB" modified="2023-02-22" version="1">MRALETGRPMLRATNTGMTAAIDPYGRVRAVLPPLTPVATGVVQQIQLLVTGHTFCHYPQAQLLRHDNHGLSQHQILAAQGQIADIALINLEHIDGNRFRCDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ00</accession>
    <name>A0A914YJ00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJ00"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19491.t1">
        <property type="protein sequence ID" value="PSU_v2.g19491.t1"/>
        <property type="gene ID" value="PSU_v2.g19491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="106"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19491.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31028" checksum="5CDA9AAA91406FEF" modified="2023-02-22" version="1">MAEALSDHMTEYPFTLKWSISEGRLKALKDSTNNECLRSEFIAINSSGVEYYLRICPNGNSDERRGKTVKVKGIFKIKNAESEMELLESKWKTLKHFGDLWNMGFEDFTIIADKKEIKIHKIILAAHSPVFAAMFKSPMKEAFENKVEIPDFSFDIVEMAIEFCYHQPHDKNISFDKLVLLLKFADKYNISDIQENLEEYLCDKISVSNVAEIAKCAAAVNAVKLQKKCLDFFINCLKMKYSVPKMELLDKDFFMNAVTKFLYQTSETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKF9</accession>
    <name>A0A914YKF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKF9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17798.t1">
        <property type="protein sequence ID" value="PSU_v2.g17798.t1"/>
        <property type="gene ID" value="PSU_v2.g17798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17798.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15264" checksum="B21DA334A77AEF20" modified="2023-02-22" version="1">MESIWEGGQAFVAFSRVETIDGLYLADYHPLKIRVDKSCLVEYNRLRESIGLTKFPIPSGKTINKGPEPVNIASQRRFRKRSSLATNVIIPTKIARIENDNENVVMVEEDGDNFDIVYRDVNGEALRQFNSTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLL0</accession>
    <name>A0A914YLL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18208.t1">
        <property type="protein sequence ID" value="PSU_v2.g18208.t1"/>
        <property type="gene ID" value="PSU_v2.g18208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18208.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20601" checksum="40291267CD600B13" modified="2023-02-22" version="1">MFLVLRGVLENLGRLVLADNLFESLELNAKCLPSLRLLDLRNNRFEIIPAMIYKGILDLNAIDISQNPLQCNCKLEEFIKFANEDSSIFLNQGKTMCKAPTELAGKGIFEIDTDATNLCQRSSRLLHWIILFLIAGGCFYVYRHLRRAGKLPRMPTVFGYSQLKSNDEMNNNNNNNQPAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM67</accession>
    <name>A0A914YM67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18416.t1">
        <property type="protein sequence ID" value="PSU_v2.g18416.t1"/>
        <property type="gene ID" value="PSU_v2.g18416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18416.t1"/>
        </source>
    </evidence>
    <sequence length="940" mass="103477" checksum="561A86EB88B76175" modified="2023-02-22" version="1">MRSTDLSSVFSTMQPSIIIACLHNAITMQNREAGSRSVCSPAHRWRPCNAHCNQILVARLLLFLSSYKEFRHKLCDAQTFKSLTQLLETTLDPQLLCLLLQTLSIIAMDPDTHAMFLESQIDDTLVQMLLPADDFYYTNQSTKFGIFVKHHAARVLVYIGLGDRVGARVNLFQALDSLTDQPKKPQTSSHGSGNNTNEDEYIIETCKTVFSSHEFSKNAMSVEGVLQKILAELAKQAPYPNTSEPITEETPGTISPPAVAVEDDLTPPVTIEDPKNISVETKTIETKVEEIGTKLIPKSAESKPIPSKSDEPPSAKPSPNIKHLEEPKIQKKRKSVREKANVLKVPSNASSKSDKSEKKHHHHHAPLTPETSSTPSTTSSTTNNNNNNTLTISPSINPHIPAITATASSPSASLSQGNQPTVTIPPTASFAIASSSPYGPFSVVSLPSIICVANLENYLCKTSLVLDSMLILRLLLHKLRWDLGLVSKRRSVITDRGERNEKKDSTAERNFVKSKSFDRREDSSVKSDKRYLRVNQGSRLGRRVHIRRSSSVDHLQILRPKRFSSGAKDLRAKERRKRLGTDTSSGSGRSKKTNSSSSSVHKHLPRYIQSLFRGRMGTDPCKRHSPRGDSSPDSNTSSSDAVLEFTRKLQNFPQTRRETMQQAYRNRGQQDSNNSIQNGESRARALGYNYLPEVEVNGASPPRSPMHGSIEGRDSGASLLSGTRRPSSPQAMPGLPLIEIRRPSKISQFEFGYFVNSPEICGTISADVSDCAPLLLTGNSITNGSRKSSDESSVCGSVGGIWSSRASSAMSQRSSSGGLRLSTFSAGTSICSDNSGPFLFSFVLRKRASTIGTRIPLPKRAISRASGASDSLRVPDRDSPLHLLTITEMSPDFQCVRQLLLNLILMYTKNHPNFVQTMSSIQQLFRQVLNSPQHPTVKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM97</accession>
    <name>A0A914YM97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20699.t1">
        <property type="protein sequence ID" value="PSU_v2.g20699.t1"/>
        <property type="gene ID" value="PSU_v2.g20699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036723359" evidence="2">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="3">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20699.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8784" checksum="AB2323A26EB9A165" modified="2023-02-22" version="1">MKFNIFLVFALIVLSIALVSAQAPQCGAFEKFKQCASSCEPACDQPDSKMCDKKCNPPKCQCMKGMVRSKEGKCILRADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMR1</accession>
    <name>A0A914YMR1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20873.t1">
        <property type="protein sequence ID" value="PSU_v2.g20873.t1"/>
        <property type="gene ID" value="PSU_v2.g20873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22709">
        <property type="entry name" value="FHA_KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000063">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000034">
        <property type="entry name" value="kinesin-like protein KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="7"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="386"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20873.t1"/>
        </source>
    </evidence>
    <sequence length="892" mass="100131" checksum="C27CF56995908383" modified="2023-02-22" version="1">MSDSGETVVVAVRVRPFNDREKGRNATLIVNMPDGKSTSISDPNAPNEEPKWFTFDYSYWSHDGFKTEKNGYLTAASHSNYADQKHVFENLGKGVLDNAWNGYNCSLFAYGQTGSGKSYSIVGNKQNKGIIPLVCEELFNRIESTKSKDVEFQVSISMLEIYCERVRDLLSSKAPPKGGLKVREHPKQGFYGKGFQTINFLINAKLLVEDLTTTPVNSYKEIEKKVNEGTKNRTIAATNMNATSSRAHTIVKILFIQKIPKPGGGTTTKSSEINLVDLAGSERQKDAGSEGDRLKEGIVINKSLSTLGRVIKALHEQQSAKKKTSVQVPYRDSVLTSLLKNALGGNSKTIMIAAISPADINYEESLSTLRFADRVKSIKTKAVVNESATERMIRELKEENARLQELIRRGGVNGSAVNNDEMENLKRQLEENQKEMENLEQTWQQRLAEERKKRDSVSEDKSEIDKKKKDLPHLWNLNEDPALTDMIVHFIAQGENVVGNGNVTTPQILLKGMSIQPEHACITNKDNKTIIIIPYSGAEILVNGNPINQATELQQNDRILFGGNHLYVFTNPKKKGAKTSEQITYDFAQKEIAKTHGISAVGDGKRSTADLILEEDLIKILPNVHRANSMAKELKKPVKFEIILNAPEARGLSEGLTEIFIKVYNTAEDTTFMWDKNRFTNRYYGMQEMYQNYVDGDSDYNLPPERDPFYEPPDSTIILGHASMFLQSLAYMVEAEEQLSIVDFNGMDLGQLSVSLVPCSSSGKEIMGEYLETPDELLNKNLGIKIKILAAMGLPRRIDKSWCTYRFFTHDEASTNKQSGHNPNYSHENVITFKPVTKELIAYLTNGVLTFTIWATQKIKKADQLELVGLQQLIKRENLHSLQLRVQILKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMU4</accession>
    <name>A0A914YMU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMU4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2215.t1">
        <property type="protein sequence ID" value="PSU_v2.g2215.t1"/>
        <property type="gene ID" value="PSU_v2.g2215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038009230" evidence="1">
        <location>
            <begin position="27"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="49"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="170"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2215.t1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46850" checksum="343926DC5E19AEB1" modified="2023-02-22" version="1">MMAYFVFLFISLAVVDINCLILPSNTLPINTIQNKDSFQCDNGWHWLQSKKTCISIQDTPLNWSDAESQCVTLGTHLISIDNAFEEDAAKNVMQQYGTCDYYWIGAKRGADGNFSWSDKNQFSYSNFGPGGDNNPRENCTDINERSTFWRTLDCSDKNCFICENPDPSNLPDFAIYTDCAELKEAGQTKNGFYYISTKTGAKKVFCDMEVNGGGWVVIQQRVDETLKFWNQKWNAYKQGFGFFAENSNFWIGNDLIHELSSKDAKVILRIELWGDQNPTSPYKNDYWWSEFNFQLEDESTDYTLHASILQRYPNDWKGTGNASTNWYDVTCEEGVKFSTVDKINDPMSKCVTDYHLGGWWLHYCSTVSLNGEYKPAKYADGYGFMWLIDGEYMINPIKSRMLLRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMY8</accession>
    <name>A0A914YMY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2255.t1">
        <property type="protein sequence ID" value="PSU_v2.g2255.t1"/>
        <property type="gene ID" value="PSU_v2.g2255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2255.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9664" checksum="6AE9F3C926DD2BC4" modified="2023-02-22" version="1">MYGNVSDSDESETSESETESIDVPRKKPNRVSVKQTNVVLTKVTAVDAPPSETSETESFSSPRDRNHQRDNNYVVLTDEEFSEKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNS7</accession>
    <name>A0A914YNS7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cysteine synthase</fullName>
            <ecNumber evidence="4 12">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914YNS7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2507.t1">
        <property type="protein sequence ID" value="PSU_v2.g2507.t1"/>
        <property type="gene ID" value="PSU_v2.g2507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000002">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000067">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 10 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="12"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="183"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2507.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="36718" checksum="61AC7043DE9FC0DD" modified="2023-02-22" version="1">MADRNSIAANASELIGNTPMVYLNKVTEGCKAKIAVKLEYFNPGASVKDRIGFSMINEAEKAGKIRPGLTTLIEPTSGNTGIALAFNAAAKGYKLVITMPSSMSSERRTLLRAYGAELVLTDPARGMKGAIERAQELSKSIPNSFILQQFENPNNPKIHYDTTGPEIWRQTQGKVDVCVFGVGTGGTISGAGKYLKEQNPNIRIFAMEPEESAVLSGYPAGAHKIQGVGAGFVPGTLDTHIYEDVVKIHSDEAVIMARRLALEEGLLCGISSGANVCAALRVANLPGMEGKLIITVLPSFGERYLSTVLYASIRDETSQMNVETLDENLKRLNLHEFPEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP10</accession>
    <name>A0A914YP10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP10"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19091.t1">
        <property type="protein sequence ID" value="PSU_v2.g19091.t1"/>
        <property type="gene ID" value="PSU_v2.g19091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="141"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19091.t1"/>
        </source>
    </evidence>
    <sequence length="532" mass="60897" checksum="EA100EA70595C4F5" modified="2023-02-22" version="1">MSYVYPQDEKIKTLIDRIAVNVAVNGPHLANHILQKEQGNPAFSFLIPGGQYHDYFEYQTSLAKKQQQQQPNLNSAPLNPLQPRIDVEGIKKQIETLKAQVAESDKNVASQKHVLTHALETQMEKLYIKSQQEKIDKFITDSSLNITGLIKVLDENSYSPETVSAGKHWIFNNCTSDRQKEVVFLYLLFRTKTSSLDSPIRLLIVYIADELAAYCHKKLPPLCSTIARYVPKFFAYATESRIPKIKDKLDKCLKYWSRDMYFDDKCLQAVRDPQKTLMNERNMEIAEKHTLKMQLEQENRKKIASYEKQNADFASHISAQISALEATIENENRRIFMLTTPKEIAPTVPYYCLPAGVIVNMVKPEDFYYKPLKVEDIKVPNLVAPTERLTSQITRFYSVMPESSCDEQGWETDGLMYHYDAKNAAKKAMEEALIDQGKKLEDIFTNRYKSPSPDAEALRKTRFDIKPKEKAPQPSHQFQYSYDDQPKESSTDKHTSSTYDDNDDADMPDYSRSGFGSASNTSVNKPNAAPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ20</accession>
    <name>A0A914YQ20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21124.t1">
        <property type="protein sequence ID" value="PSU_v2.g21124.t1"/>
        <property type="gene ID" value="PSU_v2.g21124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21124.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21454" checksum="D96436441E249EDD" modified="2023-02-22" version="1">MGKWRRAGIPKTKECDTHRKTFLAPEFNFSYHPFLGTILISNKLAWSATGLKIIIGGTMDIANALQSSSEGFLKIRYNLLAFHDGERYWRVPDIPNEMFDSKNFLIEKGVPLWGEPLNTSKKIHPPQSLFKELKIEGRFLSQHFIKHPEKKRPLKSTKKDECDSASMPDSDVSYVLHSSYQVSAGDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQI1</accession>
    <name>A0A914YQI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQI1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21310.t1">
        <property type="protein sequence ID" value="PSU_v2.g21310.t1"/>
        <property type="gene ID" value="PSU_v2.g21310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21310.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22199" checksum="90D378BC8373E17A" modified="2023-02-22" version="1">MAYLRDPDITEKAPSNSISILLPKIFNYRIKFLGFQNQELTFQEYKYLTLNDKCQVVFTDCKITENKFIVPAEKLLQASPNLCQFSLYFDINKELSYCTSLTSKKLAEFPPFKYLKHFVLYNLSGNFNALHFVEFIKKNYQNGNGSCAKFGVSFKENVSHQFIQNFKSVVNSSVISMKDVKREHIFFNGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQJ2</accession>
    <name>A0A914YQJ2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Trehalase</fullName>
            <ecNumber evidence="2 4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2 4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YQJ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21327.t1">
        <property type="protein sequence ID" value="PSU_v2.g21327.t1"/>
        <property type="gene ID" value="PSU_v2.g21327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF3">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036861520" description="Trehalase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21327.t1"/>
        </source>
    </evidence>
    <sequence length="648" mass="75108" checksum="06932C28C523E92E" modified="2023-02-22" version="1">MKYILINYCFIFVVTNAFRSGVYDSFRRETEVNNTKTKKTNFLSLNEFLHTECSEPVCDGELADIYCRGDILATAWYFNLQDVCPGTKLQLPVETVLKNFAKLSKPIKIEDFKEFCSENFEFVPYLEAARIADWNSNPDMFKKINNERILFLAKFINRQWPLLSRKFTNDVLLNRTLYPVVPVPNAFFVPGGRFQVYFYWDSFWILKGLLATDMIDSAKNILENFAFIIKYHGFIPNSGHIQLSRRSQPPLFTQMIADYFNKTKDIQFLKSVLPLLKKEMQFWENNRTINITFDGNNHSFFQYRSISNCPRPESFLVDFLAAKDQSALPNEVIWSSLASACESGLDFTSRWFGNPKNRKGIRTNLIIPVDLNVFIVQNFQLISGWSEFFGDYKEAKYYNQKAKKLLNSINTVLFDKEEGAWFDYDIHTKLLRKDFYPSNIFPLMINYDNRNFCDKIINYLEQTNIFDFKGGVPSSLDNTSHEQWDYPNSWAPSVHLFVESLSSCSSNYKAKIYAKTTALKFVFNVLNGVEKFGKIWEKYDARFDDGRSGEGGEYLPQFGFGWTNGAALEFIKVFFTDESDVIGLQNSFAQKISERLITSPAEKGNDTTIVFSIAIMICVFIAFFGFWILSKSRKPHIGEKTYLLSVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQP5</accession>
    <name>A0A914YQP5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g19689.t1">
        <property type="protein sequence ID" value="PSU_v2.g19689.t1"/>
        <property type="gene ID" value="PSU_v2.g19689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="entry name" value="EAL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050706">
        <property type="entry name" value="Cyclic-di-GMP_PDE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33121:SF79">
        <property type="entry name" value="CYCLIC DI-GMP PHOSPHODIESTERASE PDED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33121">
        <property type="entry name" value="CYCLIC DI-GMP PHOSPHODIESTERASE PDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="EAL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19689.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40507" checksum="58D571E14DD66AD9" modified="2023-02-22" version="1">MLNELSPRMILQAWSVRIGMTALGLALGVAIIGADQLPVAELAIQRLLALPVSLLMLGAVFALVYNDAQIDAQRQREQAWLRVDPISGLPNMRALGERLQHFWRDNDGLGKACLVVVEMGNQRDLRLRYGPLQDNGLWHRDTPAEVHRLLPSLPVDDVEVYQFGDAALAILVRGMSLTELRIQAHITELACNLADRVGRDWPGFRPLFRCAVVELKPPTATDEGHLPFRAITLALSAIESGVVFFDDPIQRDSEIDALIEVALERWLQQGDAPLCYQPKHRLHDRQLVGAEALLRMRDGEGRPIAPMRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRF6</accession>
    <name>A0A914YRF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRF6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3344.t1">
        <property type="protein sequence ID" value="PSU_v2.g3344.t1"/>
        <property type="gene ID" value="PSU_v2.g3344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF9">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="171"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="235"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3344.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32329" checksum="29CC38FBBBC32D4F" modified="2023-02-22" version="1">MGFWCHIGNTPATFFCCPSNRKVPNLCHLPPNSGFGSDKINRYWYDWRSGFCREMVYSGFGGNENNFVVRDKCEKRCAGTPKPSTPLSPERKSSGDIKVDKGLLPDEILSITKSPKVVAPPSIPLSTTVRPRATTLTFRKHPSTPTPPPPSTSTNSKSPFLTLNEKAVNPCNFPPDKGEKLSPTDSPIFRWYFDRVAEKCVQFYFLGSKGNSNNFEHEDSCLETCGGGPNEITSCKFQMEPGFGDYLIARYYFNEKSKSCRKFTYKGYGGNYNRFTSRSTCEKSIETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRR9</accession>
    <name>A0A914YRR9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine synthase</fullName>
            <ecNumber evidence="4">2.5.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Putrescine aminopropyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YRR9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2348.t1">
        <property type="protein sequence ID" value="PSU_v2.g2348.t1"/>
        <property type="gene ID" value="PSU_v2.g2348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="12">
        <location>
            <begin position="6"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2348.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35210" checksum="02DA0E599D756C54" modified="2023-02-22" version="1">MDLLQKGWFTEFSPDDLEKIKKTSSGDSKQLKSDGKEMGGAWPGQAFSLQIEEVLFHEKSKYQDVLVFKSKTYGNVLILDGIIQCTERDEFAYQEMLAHLPLFAHPNPKKVLIIGGGDGGILREVLKHASVESVTMCEIDEMVIDVSKKYLPGMAEQFGNPKFNLFIGDGFEFLKNHKNEFDVVITDSSDPVGPAESLFGQSYYQLLSESMKNGGILSSQAESVWLHLELISHMIEFTKKIFPTVQYASSIMSTYPSGTMGYLIASKDNRDVTKPARTLTSEEIKSMNLKFYNSELHSAAFILPTFVNQALQGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSD4</accession>
    <name>A0A914YSD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSD4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20312.t1">
        <property type="protein sequence ID" value="PSU_v2.g20312.t1"/>
        <property type="gene ID" value="PSU_v2.g20312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20312.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11155" checksum="9508B32996C7A6D8" modified="2023-02-22" version="1">MAPQTSMGATAVNNIEANSSGPYTPAKEKDGRIIREEIVEQVYRISGTGHAPNLDPNDMSLQSTVDKCIRDTERMPRVQMVEANVLVKECEPLPHGISASFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSS2</accession>
    <name>A0A914YSS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2705.t1">
        <property type="protein sequence ID" value="PSU_v2.g2705.t1"/>
        <property type="gene ID" value="PSU_v2.g2705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="63"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2705.t1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39947" checksum="D7752C4E66A0F6FB" modified="2023-02-22" version="1">MFNFTVKRIDQQPGTSHQSQQHPRYDLRPRKNRSDIQHISIAGASRDKPPSPTSVLRRFGLRTYSSFELGCGHYSKVYKAYQADREVAVKVIKLDQVGTDFKKRFIPRERECWSKLRHRNICELYQIVACNDFNYLFMVMEFCHNGDLLTYIQANGPLSESTGRRWMRGLLEAINYIHKLQYAHRDIKAENVLISRRHTVKLADFGFACPQPSNSAFFSRTYCGSRAYSSPEVLTGIPYDVFKNDVWSLGVLCFVSMTSSMPFRELANTNTAIVEQQRRKQYRWPTYVSHDCQQSIDAMLTFHQDERPTAKEAKKLPFFERGGGINQSQQKNSPEEMESVEFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT75</accession>
    <name>A0A914YT75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YT75"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3364.t1">
        <property type="protein sequence ID" value="PSU_v2.g3364.t1"/>
        <property type="gene ID" value="PSU_v2.g3364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3364.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35138" checksum="EA46AEEC0B05CDD5" modified="2023-02-22" version="1">MAANVLLTVPLPASPEAGCTPSSGQNSPESAASPASRQNDLTVVMHHHEKRKKKPYKELTLEEKVRLIKMAEENNCMSQASIAERYSIAKSNVCRILQRKHEYLRAYESAGFAGTRKRKLRNDNTITTTMVLTNNMKSKREKGQNDANGESILKPIPRKVVIKNADENKRNTNAAAKEIGNDSCQSFMNPVDPIINQLRNGSNDYKSAFRHLKPLESPNLYDANFITSQLLMSFPSLSYIDDSVMLQAKTLANPALNLFLNHALSKQIEFLNEKLLQNEQKQSKIRNFIQNAENAGLARSSDAQQLVHSLMSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX78</accession>
    <name>A0A914YX78_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914YX78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4711.t1">
        <property type="protein sequence ID" value="PSU_v2.g4711.t1"/>
        <property type="gene ID" value="PSU_v2.g4711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000518">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="9">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="123"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4711.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21884" checksum="073452FC6220F6DF" modified="2023-02-22" version="1">MGDAAIHTLPYFHGLLPREDLIQLLKVSGDFLIRSTEPRPGQQRQYVLSVMVDEKLGGDGIKHLIFNSTEPGKYLLGTMNDTVTNIIEHYSRSGTAVVHLNDLPVIIKTPIGRQKWELLHDNIQVEKKLGAGAFGEVCMGKLKLSNGTQTNVAIKVAKLESLTKAQIKEIMAEARIMRTFDHPHVVKFYGAPWMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY55</accession>
    <name>A0A914YY55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAM-dependent MTase TRM10-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YY55"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5430.t2">
        <property type="protein sequence ID" value="PSU_v2.g5430.t2"/>
        <property type="gene ID" value="PSU_v2.g5430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF5">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="5">
        <location>
            <begin position="140"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5430.t2"/>
        </source>
    </evidence>
    <sequence length="377" mass="44647" checksum="944B4F8744A307F5" modified="2023-02-22" version="1">MAASKLTKFMPSNKFLSSLKSSTDGEQKVKLVNRILKELELVDYFHTKVPEFLNDYHWEKLVRSRHVADRVSMIEYFALSQRREKNDKERREARLKAFNEQMEREKAKYENGQMGYGPYLYQLMLNPMRNMKHINLVNGSRQYYTRMLAETPKVAFDLQFLQHMPVSDASKIGAQVEMCLAENTNNFRRPFHLEFLNLNLSDQTFNLKAPLAAVTKHLIKEHADQQIVPDFYPDMHYKFNDKNVYYVTKFAKRFFEGPLDPSKTIILPATMDKENIIQSINVVKKYRFTPIYLPIRKYIKWESGGFYMPLPNILRTLKIVAETGGDWETAINQNVAYRHTIPIQQQREKIKHIYDEKQQLRREKTELIKMIENTVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZM2</accession>
    <name>A0A914YZM2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5946.t1">
        <property type="protein sequence ID" value="PSU_v2.g5946.t1"/>
        <property type="gene ID" value="PSU_v2.g5946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="9">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5946.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34735" checksum="1602A79F59EB100A" modified="2023-02-22" version="1">MVREDKTVWKKNYFDRLKTLFDEYPKCLLVGVDNVGSKQMQEIRIAMRGHGEILMGKNTMIRRAIRGHLQSRPELERLLPYIVGNIGFVFTSEDLGEIRKKLLENKRGAPAKAGAIAPCDVKLPPQNTGMGPEKTSFFQALQIPTKISRGTIEILNEVHIIKVGEKVGASEAALLNMLNIMPFSYGLAVQQVYDNGTIYSPEVLDVTNDELIKRFQQGVANIASVSLAVGYPTRASVPHSIANALKNMLAVAAVSDVKFKEAERLKEYLADPSKFAAAAPAAKKEEAKKEDAPAKKEEPKEESEEEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZW3</accession>
    <name>A0A914YZW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BLOC-1-related complex subunit 6 C-terminal helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZW3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3569.t1">
        <property type="protein sequence ID" value="PSU_v2.g3569.t1"/>
        <property type="gene ID" value="PSU_v2.g3569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019314">
        <property type="entry name" value="BORCS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046465">
        <property type="entry name" value="BORCS6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440">
        <property type="entry name" value="BLOC-1 RELATED COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440:SF7">
        <property type="entry name" value="BLOC-1 RELATED COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10157">
        <property type="entry name" value="BORCS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-1-related complex subunit 6 C-terminal helix" evidence="3">
        <location>
            <begin position="69"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3569.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19665" checksum="843F42FD8C941531" modified="2023-02-22" version="1">MSKENNSGIAADDLAERIVNLVGMTEEPETSASSSPSLMNSPERRPARIDASKTIKTTRQRRPSNELLPDPSVLRDLELHARSISSNVDMCLRDLRGTLRGMSDLTLEFMQTYSSTINSTCDNVDAAIKSQYKLIAKAEELNETMQDARKVAQQVKDMKRLVDLLESRLLADTHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0D8</accession>
    <name>A0A914Z0D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0D8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5812.t1">
        <property type="protein sequence ID" value="PSU_v2.g5812.t1"/>
        <property type="gene ID" value="PSU_v2.g5812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF93">
        <property type="entry name" value="RESTIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5812.t1"/>
        </source>
    </evidence>
    <sequence length="434" mass="49127" checksum="6E82F7B32A3BACEC" modified="2023-02-22" version="1">MATAKPNYKIGDYVLSKKGKGTVRYVGPIEAANDQTKIFAGLELDEPNGKNNGSTQGKVYFECPENYGIFVPVETLANLPKMLTKPPSNPVRSNRASELRQELGSTIGSDITGVTGMSKMSTFNNMPAVRQAQNVNTKTYHHDLQANLKKVLDQLEAEQDKNATLQARIQELERATGSGDDEEFEKQELIVKVESLEEVKKTLEEKLRETNVSLERNMAMLASQNDEVHLLQKTVEDLKVSNTRITTASASPHFNNESILKEKDELSKRIAVLESNLKEALTSSTQTQEKLNENLINAKKEAENHVKEKNELLKRLQEVETKFSNILKSEAEIQEKLNQDLTDAKNQAQNENIRLLKHLEEVENKLSDTLKAEAENNRDFDMAKEEAENFVKEKRELLDHVQGLKEKLDDASKSAMNEKNELSFKNWKRNSRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0W3</accession>
    <name>A0A914Z0W3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H2 subunit B wHTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0W3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5999.t1">
        <property type="protein sequence ID" value="PSU_v2.g5999.t1"/>
        <property type="gene ID" value="PSU_v2.g5999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5999.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29013" checksum="5CC4B17D481A403E" modified="2023-02-22" version="1">MLRGSAECKLRFLTKPTDVSLNNALIRRITEPGSGEEYLYAVCNENLMEIIEENGPDRAVYAHGKFWPPSHHLFFSTLDPFFFVAAKLNPTISKSWEDLTSDFPELSKNARLCKLRDDYCTSVDDNYLATDEQLFKYYTIMFAKLCTCRIIHARKRLDMKLSTYLSMHPQISWFHEFVKLVPSKFHTKLAEHFNINLKAHMPKVSTIEYGKNEDKEAFKAPPPKKAKVSTSQKQLAKASKGTKSITGFFAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z193</accession>
    <name>A0A914Z193_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Farnesyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z193"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6487.t1">
        <property type="protein sequence ID" value="PSU_v2.g6487.t1"/>
        <property type="gene ID" value="PSU_v2.g6487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6487.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26350" checksum="625D439EBF722300" modified="2023-02-22" version="1">MPSVGMAALNHALRLQNFVNISIFNSIPNHPNLGEILKVAWETIQVTSDGQELDGFSSKASDCTFERYSHIVANKTSRYTFYYPITVAFLLANENEHMDQILELSEEFGYFFQAQDDLLDFKDNDEITGKTCCDIREGKCTWFSCKTMEKLANDSEKRRQFEECYGSNDPVKVSKAKKIMEDCNLIQDFEIFQEEMVVKINQKIDKFPVDKVKIAFQTIFNSLINRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1I6</accession>
    <name>A0A914Z1I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1I6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6573.t1">
        <property type="protein sequence ID" value="PSU_v2.g6573.t1"/>
        <property type="gene ID" value="PSU_v2.g6573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF12">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036834172" evidence="1">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6573.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32677" checksum="EEEC94FD4FD34C91" modified="2023-02-22" version="1">MKIETAIILLMLFELVSLFHPEVEWSCETFSINLDIKTELQFNGIAHSIGRRSECYVYGKNSTLTNLVISMQPNENNPCGVKINQDTDFYWVEIEVHRHVIFSMLEDCTFNITCKKRKTYFDKNDTKIIGHKKTSVPKMLTTFELLANDHNYLSVIDTLTFVKYGESYFIKVSMENFEYAQRFRVTDCIAESEGLVAELFDSNGCPISEEIKNFDYKNGYATALIPSFFRFFNFKLLKIECKISICDQVLGCQPQCNNLATNLLDNSNQTVLPAQIIFLKLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2L4</accession>
    <name>A0A914Z2L4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2L4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g695.t1">
        <property type="protein sequence ID" value="PSU_v2.g695.t1"/>
        <property type="gene ID" value="PSU_v2.g695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="640"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g695.t1"/>
        </source>
    </evidence>
    <sequence length="809" mass="92338" checksum="9EE39D5E7908AD39" modified="2023-02-22" version="1">MDTSSKEKTIIDEIARCLDLLPTSSSNIAPERLQQQRREHEERNRRRIEHVHNAVAESVTALRTEIKRIEGLIDEGIRNRDIDAVTKLDHGEWKLVKQTIGDLKQSLDTPQLKSLRDNWQSAFDDLESNAFNVDAKIMKFNRRNEKEQRLLRNLAAFAEWIDLVEKDLVQIESRVDLETLEREAQLQKLKENCEKHQRLANKLELHKFQSEQQSTFAKEQTTKYRDILDRLNRMNLPTLKEISIDIRADLPSTAAQSQLSIASTSSFGSHIEGNEEDLESDLASVHSEVIRTESERTAHPIAILATPQEEADLLRQVALNPKAPKPMDDIRQAIATICEQLRGIRDFYEMLPLKPVERAEHDVPQLNELIANATTAGKHLATITHASRKSPSDHTLLESLTNDLRGEITAATNLVESLEREIQDERQLQLNYNQIMADLNKIEADVRASAEKGVRPKVKDDLRTIELEMDVLRRLCKKPRRYIASSIDGSPLSTPTRRRRIVLKITNSVLTIIKVVEEQLSKTLPSKERKALKDAAELNPTLQGIYDNLRNIQRKMEEDVSPPISAQPSFENGDEPVDVAKLIEQAEDIKQNLEKLSEVDEAIEEPEQYALLIKASREGRSGLEQILTKIDESSDTPETVQEYRNHVVDLVQSLLNLEDQLTHKLKRSAEIHDKYKIALEKTNEAKEAAEEVLQEINPSTTSLHHVQKTIKSALKEAEELGQKQISLPLATNLQTQCKELQAISENINKKLQENDELKHLVKQTQNIIQNWEAKAKDLENKALMDIEVAKEEEKQIEVSQKPKPFSKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z300</accession>
    <name>A0A914Z300_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z300"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4632.t1">
        <property type="protein sequence ID" value="PSU_v2.g4632.t1"/>
        <property type="gene ID" value="PSU_v2.g4632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38629">
        <property type="entry name" value="PROTEIN CBG12672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38629:SF1">
        <property type="entry name" value="RNA-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4632.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="9479" checksum="AB4B874B997B5139" modified="2023-02-22" version="1">MADKSAYVPVEAAGGAAPSGKPRPAELDIDIDDNDYFGGGKSATSAPPPAAAPAPPPPAPAPAPAPAPAASSAPKKHVYQKPKSYQKTYAGQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3Q8</accession>
    <name>A0A914Z3Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3Q8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6650.t1">
        <property type="protein sequence ID" value="PSU_v2.g6650.t1"/>
        <property type="gene ID" value="PSU_v2.g6650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6650.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7385" checksum="FAF58FDC1EB2C0AF" modified="2023-02-22" version="1">MNSLNYVGCLNSNIISGGSLFDIRLKELVDNLLKTTTPASDSNGQNHATKLIGIIIFGWIFAFWNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z444</accession>
    <name>A0A914Z444_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Shugoshin C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z444"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7120.t1">
        <property type="protein sequence ID" value="PSU_v2.g7120.t1"/>
        <property type="gene ID" value="PSU_v2.g7120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7120.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30357" checksum="A6730D934026D2F7" modified="2023-02-22" version="1">MINNFKITVLRKTLSSRGEEERRKAIDLECMRETMKNLSEKNKFLAKELEIKNDAEAEYIAIKGAAIKIEKENELLKKEVARLKKQFVAAESRADENAHIISKSTSSRVAFDKIYQHVQEQANLSNVQSTPRPILKQRTQSLTRTEEADSGYREHLGRKPSPIRSSYETPISQFRPSTSKDDKISRKRGIMLDYSEPVNRRKLDFKLQKLSGRNKSRELDHLKSHYDPATGSYDQSHGESPKSAAKLSTPKKENRILDSILRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4E3</accession>
    <name>A0A914Z4E3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4E3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6760.t1">
        <property type="protein sequence ID" value="PSU_v2.g6760.t1"/>
        <property type="gene ID" value="PSU_v2.g6760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF1">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6760.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11853" checksum="7C1586309643DEAC" modified="2023-02-22" version="1">MKSFTRTHSCATLLRIRRFVEAVLTYTNSTKVDIIAHSMGATLARQIIRGGIIQDNIEACMIGKPINEQIRTFIGIASANFGLCTCNKETAAKMPACGVMVSRNNNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z587</accession>
    <name>A0A914Z587_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z587"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5416.t1">
        <property type="protein sequence ID" value="PSU_v2.g5416.t1"/>
        <property type="gene ID" value="PSU_v2.g5416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="136"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="293"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5416.t1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49395" checksum="9D40769CF85F1426" modified="2023-02-22" version="1">MNDKNHILFAPPEEVRGMTKLDREKFRKTVTFPSITIPKKFIGKIVGLKVIKNATIDKLNKIKPISDGKLPDEKLILFDPTTINDDKKSEICAAINNVAGIQAEFEPTKVELTYDHWDVKRCIQAVLPEELEFSGYSQVGHIAHLNLREELLPYKNVLGEILLDKVSWAKTIVNKTDSIATEFRSFDMELLAGKDEFVTKMSEQGLTYKLDFKKVFWNSRLGTEHGRIVQKLDSSSVIFDIFAGVGPFALPAAKKGVVKVFANDKNPNSTFYMEENVKLNHIKKESIEIYTLDATDFITQVIGSNIVKYATSICTASSKSLSFHSIMNLPAIAIEFLYNFRGLLSSSSEITMEILKPHKFIVHCHMFVKAYEDVPQQWYANEAMRLIREKLKLWHLEMDEVYNVRKVAGRKEMYCVTFTLPWEYLLEGYGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6S1</accession>
    <name>A0A914Z6S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6S1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7605.t1">
        <property type="protein sequence ID" value="PSU_v2.g7605.t1"/>
        <property type="gene ID" value="PSU_v2.g7605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7605.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13943" checksum="BC6D4E6F2625D59D" modified="2023-02-22" version="1">MSLPRILDEFVGSRLVHYLSIDIESYEMIVMPELIGAGKFANENITFCQIDAELHNPKQGGQHPDAEKINRVQWILDFISESSQYLPIFTVFYQPTHKVTFVNFANPECEKAFKISSYLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6Y3</accession>
    <name>A0A914Z6Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Orphan nuclear receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6Y3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6008.t1">
        <property type="protein sequence ID" value="PSU_v2.g6008.t1"/>
        <property type="gene ID" value="PSU_v2.g6008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052496">
        <property type="entry name" value="Orphan_Nuclear_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519:SF1">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="174"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6008.t1"/>
        </source>
    </evidence>
    <sequence length="553" mass="62340" checksum="8F35C02032015550" modified="2023-02-22" version="1">MSNGASTASFTIRERPSNPPQSSTSAASTPTGEATCAVCGDGCAKLHYGVLACYGCKGFFRRTLTGKYRYVCRFGNNCVVDKFQRNSCRYCRFNRCLEVGMDPKAVRPDRDLTGKQKVPRVRKRAIDDELINHMMRLQGDDWSRKIPVDAKVLLMQLLNIESKVSKGDQNNSIQGEKFVNNKNISLRELFEQKPNLSGRRTEMRYEPYRMARSEELSKIAHRGAIAAVDWVDSLAEIGDFADTEDKISLVKACYAPLTIFNFSARTAQNTKNPDILCLCSYSYVPRKLPPEFNGTNHLSNNLIDRTLNELVAPLRKLNLREEEVVPLKAIIILNNTAKGLSPQAQEQVFELRNKIQDMLFQVVKELHHPIYNPSSRFGNLLLLLPTITTLSGVMCENMQFCQVFGQRSNLEPLLTELFNDLNDQNGQADTMSPPLFDGTEVNLQPFFQDNFSKCPQTTSVEKNDVCTQTEPENCLSPMNSLSSISLISSMSSSEHGRNRSPSIEILQNDELQEVVNLDSFESIFGEPFNNPDFSPENLFDHNQDIFNMNHGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z856</accession>
    <name>A0A914Z856_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrbG/VirB9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z856"/>
    <dbReference type="WBParaSite" id="PSU_v2.g805.t1">
        <property type="protein sequence ID" value="PSU_v2.g805.t1"/>
        <property type="gene ID" value="PSU_v2.g805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06911">
        <property type="entry name" value="VirB9_CagX_TrbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010258">
        <property type="entry name" value="Conjugal_tfr_TrbG/VirB9/CagX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033645">
        <property type="entry name" value="VirB9/CagX/TrbG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038161">
        <property type="entry name" value="VirB9/CagX/TrbG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03524">
        <property type="entry name" value="CagX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g805.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13267" checksum="42E95E613FF4C6FD" modified="2023-02-22" version="1">MPDAKAVQAKGVHMGYGANIKTAITPTKIWDDGVYTYFSFYETAPIPAIFKTITGQEMTVNSTVLSNQVVRVSGISNYWILRSGEMEVVIKRYNPVPAGVPVSRAPAKPVTKQNEARYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9D7</accession>
    <name>A0A914Z9D7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Solute-binding protein family 5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9D7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g894.t1">
        <property type="protein sequence ID" value="PSU_v2.g894.t1"/>
        <property type="gene ID" value="PSU_v2.g894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042938">
        <property type="term" value="P:dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.76.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290:SF32">
        <property type="entry name" value="GLUTATHIONE-BINDING PROTEIN GSIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037340580" evidence="3">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 5" evidence="4">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g894.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16971" checksum="400B311546A9720C" modified="2023-02-22" version="1">MKLKSILLSTALAAAVMLPGTVWAKSLTVAIPNNLTGLDPTNINDTLSQTSIRLIYQGLFGFDKDMKLVPLLAESYEANDNATEFTIKLREGVKFHDGTDFNAAAVKTNIDRLANPDNKLSPDPQRAFRCDDPVSCPSGCDDDFACRSGKIRQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9Y4</accession>
    <name>A0A914Z9Y4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9Y4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8601.t1">
        <property type="protein sequence ID" value="PSU_v2.g8601.t1"/>
        <property type="gene ID" value="PSU_v2.g8601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF23">
        <property type="entry name" value="GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8601.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31153" checksum="7C1D17C315D4022F" modified="2023-02-22" version="1">MFLTLCVPFTAIDYAYPKWVLPTWTCNMINYLQHSSAYFSVWTLTLMAADRFLAVCYPVESMTLRNPTNTCVALIVTYTLILLSQIQVGKIHDVYDYTFIAENRSACSIVSIAKGEASVTEARIYFFAFNIFGYVLPLGITCVLYYLMLKKLWYTPRPGGGSSKNTGSIRSRPETIRAKRKVTRLVLCVVVIWAVCWFPLNLCFFFSGVVYPDTLVMRGGKPIVIIQISSQVLAYANSCLNPILYALVSDNFRKGFIRVICVAANRLTFASYNGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA49</accession>
    <name>A0A914ZA49_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="11">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZA49"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7118.t1">
        <property type="protein sequence ID" value="PSU_v2.g7118.t1"/>
        <property type="gene ID" value="PSU_v2.g7118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7118.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25044" checksum="D15C175D71B28756" modified="2023-02-22" version="1">MDWLIGDKPSLPVNSEDVHFIKTPKEYYATLLARIKTSKKRVIFSSLYLGTGDLELDLVNTLKEALETNPALKISILLDYLRGTRPSPEKSSATLLSSIADKAKVFFYHTPDLRGIKKNYLPAKFNEIVGLQHMKFYIFDDSVIISGANLSDQYFLNRQDRYVLIENNPKLVDFLENVFNTIAASSFQLKENGDLDLSDNCIHPFEGNKAAFCEHVSTQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA70</accession>
    <name>A0A914ZA70_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZA70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9562.t1">
        <property type="protein sequence ID" value="PSU_v2.g9562.t1"/>
        <property type="gene ID" value="PSU_v2.g9562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="280"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9562.t1"/>
        </source>
    </evidence>
    <sequence length="731" mass="83990" checksum="49761022CCAC88B2" modified="2023-02-22" version="1">MLSNFFGKWLNGYKLNDDNKLTPPPSDPRQSQTLSFTTTKSSFHKNSSSSSISIDFNIPDEFESKYDTPPMSLKRCLTDYRQQTSRQGSLFSSLSCDSSIHSKTDERNEKMPFCDILLPPCTPPLNFFKSPPPMLPEIDEDFFPPPPPPHHFSLQPWPRSSSLPHVEKMDRLLNNFKDEEMFMRCVLPSQPLPNFYDSQTPSDNGLFIDEMLPLTISSSCNTRSRHMYPELPSPQAMPSIFSKSGMNQASLFQEEQELKSDYVIGGYAPLQFGTEICEKNYIVRKLGFGHFSTVWLCYDTVKKGYNAVKVSRSDPAYAQTCIDEIRFLQRIADFSSCRGSDRVVKLLDEFFYISPFGTHCCASQKPLGRSLYQLIVQYDQIGFSMPIIQKLAYHLLEGLKFLHNDCGGIIHTDLKPENITINCNPDDLHFLAKNALTDFVIAKKTVFAHAHFPPNITDVLESANSVIYFDSVKKLEKSRQEFIKEIWQNEFKDTEGEYEEFARICRENDINAMFGEVFENFDRKESNHSYESSSNDEKIDDLERFLLSSEVNFQIVDLGTAQHQDNITATQFQTLQYRSPECVLKHEITSAIDIWSLACVLFEAATGDYLFNPHGNRDDLDRNRASYDLFCCFISVLGSPPSDLKAVFPNNRIYAKLFDKNGKFINEPNFGSPSLSEHIKRHIDEKDVGMFIAFMERMLCYNPERRGSAEDLLKHKWFKNFGFEDDKEKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAM8</accession>
    <name>A0A914ZAM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7306.t1">
        <property type="protein sequence ID" value="PSU_v2.g7306.t1"/>
        <property type="gene ID" value="PSU_v2.g7306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7306.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12968" checksum="809AB81829EB41A5" modified="2023-02-22" version="1">MLYLKKQLLFLVFPDVFELCTPELKERLAPNRAAFKEYEDKAVEILRQSQLDEGKPESIKYAPFNFDDDPGSNNSGFYELQGMVTYKSVQVIRGIMLVGFVISMKWSSFYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAS1</accession>
    <name>A0A914ZAS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9419.t1">
        <property type="protein sequence ID" value="PSU_v2.g9419.t1"/>
        <property type="gene ID" value="PSU_v2.g9419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21525:SF9">
        <property type="entry name" value="CHANNEL_COLICIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21525">
        <property type="entry name" value="MOTILE SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9419.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20645" checksum="927FCC4FC01FA97E" modified="2023-02-22" version="1">MAAMNMKMKSPRLLRFELIAHKFDSISTVVYVALDTVFLPFEAIQSIHLWFNGEISGRRCVKTVVDATAAVAGGIGGAAVGASVGAVGGPVGSIIGGIIGGFFGSSVANAISDHLTQRIFDLPKSIAVERAYNFLGVRQSALNYDINQSFRRLASQYHPDARYGDKKLFMELQSNMQLITEDRKRNFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBE5</accession>
    <name>A0A914ZBE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9629.t1">
        <property type="protein sequence ID" value="PSU_v2.g9629.t1"/>
        <property type="gene ID" value="PSU_v2.g9629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219">
        <property type="entry name" value="PROTEIN CBG11138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46219:SF5">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037203437" evidence="2">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9629.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="20981" checksum="C093041C06AB7154" modified="2023-02-22" version="1">MFVGFIILGMFAATAFSQCPVGQTVAGPCILGDCPTGSQCNIPTDTCCSAAVLPPTTTTTTTTTTTTRIPTTTTPATGACVDTASNCATNVNLCSNAQYLDLMTQKCRRTCNRCSTTGTCVDTITNCNEYTGLCANAIYNDLMNQKCRRTCGRCTGTVTVPSCRDLGSDCTPKAYLCNNAQYFTLMTQQCPLTCGRCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBF3</accession>
    <name>A0A914ZBF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Apyrase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the apyrase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBF3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9639.t1">
        <property type="protein sequence ID" value="PSU_v2.g9639.t1"/>
        <property type="gene ID" value="PSU_v2.g9639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
        <property type="entry name" value="Apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036258">
        <property type="entry name" value="Apyrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06079">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101887">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR609283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9639.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27502" checksum="42ABC7CDB0A45727" modified="2023-02-22" version="1">MELSDLAVFDGNLISCDDRIGLVYKIENNYKDVIPWIFLTDGPGNVTKGLKAEWMTIKDDHLWVGGLGKEWTTTDGIFVNYHPMYVKRIGHNGDIQHIDWIDNFKKLRSALGIEWPGYMIHEAVQWSDVHKKWFFMPRRASHEPYTEATDEFAGTDLLLIADENFNHVEVKHIGSKGTGYRGFAAFSFIPGSSDNLIAAIKSEEKDGIPVASYLTVFRLSDGHVLLDEEPLKGAHKFEGIAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC36</accession>
    <name>A0A914ZC36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9483.t1">
        <property type="protein sequence ID" value="PSU_v2.g9483.t1"/>
        <property type="gene ID" value="PSU_v2.g9483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9483.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38722" checksum="749BB6F1A59FB98A" modified="2023-02-22" version="1">MGRNSDIKYYSLVLRGSTIASLALYIFRLKYLKWETVALVPESGYQSTINQSKIAIAYMNFLVHKKKAAGIMHRDNGGEKKFGDMFVDGFDHVNNVVYQVMGCMYHGCIKCRQADRSIIQWVGKSAAQLYAETVARQKKLRENLRPGIQIVEIWECEIAAERKLDAELDKFIKEHEDTSPINLRRVVSLWTTAAAKLHLYKFMKYLELDPNSVILYTDTDSIIYAHKKTVPNPLEAGDLLGQMTDEYPQKSITHYRSGGAKQYYLKYKDAKTGEKGHCCKIRGIVANAETERVITYKTLKYKPTRITTLDHTTIGPHHDFTILTRNTTKIYRTTCKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDU3</accession>
    <name>A0A914ZDU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Metaxin</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDU3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8443.t1">
        <property type="protein sequence ID" value="PSU_v2.g8443.t1"/>
        <property type="gene ID" value="PSU_v2.g8443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="10">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8443.t1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36832" checksum="993F547BD9689776" modified="2023-02-22" version="1">MQTEMELAVWPSDFGLASLDVACLQSMVAAKIAAAPVKFRFSTRPGESPAGTLPLLIHGDTKLTNFEDIAEHLRNLKQEVVLDGELTPNQRVEFFAYASYLRSRLYPALLHTLWVDNHNYNTVTHHWYTSKLYFPWNLFYLEKRRKFAQNYLKTVGKGEAELIKEALQTLNLLSSKLGDNKYFCGDKPCSVDALIFGYLAPLLKLPLPSDRLYLHLSSLPNLSRFVESIICIYLPLPDELIRQQNIEKQTWEKRKSKAQRTAEENRLRKEQKKSETEQSNASSLRDTLLFGMGALTLSVLFAVHTGMISFIGEEDDKLDVGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZF43</accession>
    <name>A0A914ZF43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZF43"/>
    <dbReference type="WBParaSite" id="PSU_v2.g89.t1">
        <property type="protein sequence ID" value="PSU_v2.g89.t1"/>
        <property type="gene ID" value="PSU_v2.g89"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g89.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28866" checksum="D4D5B54E6DAA3AB0" modified="2023-02-22" version="1">MEDALKLPSHERYDQLKKIVESPSYKEIQESGIVYVDTTFNLSSLHLTLAMFSSPHLLRDKKPALFTGCYMLSSKKDARAYEFMAKCIDKYVLPNGKIFRAIVTDADGALNLQCMIHLRKNIVVLCDEHVGHVINDIFGYVYGEVRYKGLLDEITFPEFEQKLIYLQKLSHWVANPRLLEWFKKGFKKQKLFQRYGLVNRLKAGLGFAESQTNGVEGENMNLKDGIDDYTPVQALIKKLEKRSHGKITKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFF6</accession>
    <name>A0A914ZFF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZFF6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9014.t1">
        <property type="protein sequence ID" value="PSU_v2.g9014.t1"/>
        <property type="gene ID" value="PSU_v2.g9014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="1">
        <location>
            <begin position="40"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9014.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15920" checksum="9E04B60705D02B14" modified="2023-02-22" version="1">MFPRRMSVDNAGKERIEIPSIIKHFNDSSTSPLTLDQIRMIIKKEIFLKGPTTLAFPVTEEFLHYESGVFHVYPEESFEKRIIYWHVVRIIGWGEDKKGHFWTAINSFGSQWGDNGVFHIDTSLLEKFGLEFETGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGQ6</accession>
    <name>A0A914ZGQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9468.t1">
        <property type="protein sequence ID" value="PSU_v2.g9468.t1"/>
        <property type="gene ID" value="PSU_v2.g9468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036674517" evidence="2">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9468.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26598" checksum="0447C0DF78C98965" modified="2023-02-22" version="1">MNCCCFKNLFAAFLLLNSANFQENASNNVQQLFDIHEKSVNELSSDDVGVQQGNDVKLTKEGSINLTLTFNKLEFEVCDCSKGSQICYESVNNWDGAVGSCFKYPSFCEFKVMDDKETDSLVFGQTTHVFKSLITGCPRSEMKYDYAEIKTKVLFYIKSCDPKINPADKMIKLQVIHLSLCPIIVKNAIIHLQEIASTKPPSLSQNPNDSSSTASFPWWGILIIVFAFVIAGIGIAFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU82</accession>
    <name>A0A914XU82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10807.t1">
        <property type="protein sequence ID" value="PSU_v2.g10807.t1"/>
        <property type="gene ID" value="PSU_v2.g10807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037644590" evidence="2">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10807.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16354" checksum="068A6017AD94357E" modified="2023-02-22" version="1">MKILLLLLFGIFAALASASDDQVTELPTPIPVAKLMAPHGLAKREAVVASAPKSSSSESSEEKESSLRDSTIAISTAVTPIGVIEDKGLPIVESGLRKRRETTVTETQKSEDIAAPVTEIPAADAPKIVAKRSEEEFRQPVTEPPKAAVTPEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUD8</accession>
    <name>A0A914XUD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11568.t1">
        <property type="protein sequence ID" value="PSU_v2.g11568.t1"/>
        <property type="gene ID" value="PSU_v2.g11568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11568.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21870" checksum="13BAF8AAC20F366C" modified="2023-02-22" version="1">MNSVDFGDDVFIKKATQDDFEDLLNFIKMDFCKNEPLTDALEATPEEMGPTFRDMVKASLEEPCFTYIVRSKKSNEIVATRMMAILERPSNNNCEKDESPPYKSWKANLILKLLKHMEHKVWEFLPNAQKLASGIMISVHQNYTRRGIAQKLVEYNLDEIKEAGCEGLMREATAKNSQKLFCKIRLPKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUN6</accession>
    <name>A0A914XUN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUN6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1068.t1">
        <property type="protein sequence ID" value="PSU_v2.g1068.t1"/>
        <property type="gene ID" value="PSU_v2.g1068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1068.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7557" checksum="539B3C8FB65C3029" modified="2023-02-22" version="1">MIDAVQRLNECKPVLGRKAFDLMIKVVGQGMEIKDLAESQRDRKTIGDYVKDGLDELAVHWGYKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW18</accession>
    <name>A0A914XW18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11428.t1">
        <property type="protein sequence ID" value="PSU_v2.g11428.t1"/>
        <property type="gene ID" value="PSU_v2.g11428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF402">
        <property type="entry name" value="MIP16918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="50"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="255"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11428.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="42380" checksum="E8D46E2A6B2FAF29" modified="2023-02-22" version="1">MSQINIADLPLNEQTRLSNLRDHKDGLLKEIHQLQNTLSRVNNELAAISVIEDPEERNKLYLIGRKKFNTNPKAGIKYLIEHRLLENDPENIAEYFISCKDLRKQSIGEYLGEKEDFNIKVMEHFIGKQNFRGQPLVPSLRQFLNSFRLPGEAQKIDRLMECFAKKYCEQNPNSFKASDGCFVLCYSIIMLNTSLHNTSVKEKITLEKFLQMHKDIEGCEDISEDLLFNLYENIRSEPFKSPDEDGNELGQAFYNPDRAGWLFKLGSGYRSWKRRWFVLNEMCLYYFESDNDKSPKGIIPLESICVRMVEDKSRPHTFEIYSNASEVIKSCKAEPKGKLVEGRHSVYRLAASTYEEMSAWTNAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW24</accession>
    <name>A0A914XW24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11173.t1">
        <property type="protein sequence ID" value="PSU_v2.g11173.t1"/>
        <property type="gene ID" value="PSU_v2.g11173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11173.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35816" checksum="39A0ABF048C4375D" modified="2023-02-22" version="1">MKKEEEKPEDAKSMADLLKKKREDAAKKKAEEDARKKSELEAKRKADLEAKEKADQEAAKKLEDEWAAKKKAREDEANKEKTIREKTKLEEAEKLELEKKQKKEKDQTELDAKKKKEADDKKSKEEAEEKKRLETEAAKKKKLEEDKAAEEAKKLKSVKKHESDAKAKEEAEKKKQAEKDAKNAAEAEKERLADIEAKKKADLEAEKEKERLQKTKLEEAQKLEREKKEKYDAEAKAKQEAEKAAKDQKDAQAIALAEMEAIEAAKVKLESAAKAKADAEEAQKAANELKSAKDEVEGKPTTKQHQKDKKEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXT5</accession>
    <name>A0A914XXT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 3 subunit G N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXT5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1276.t1">
        <property type="protein sequence ID" value="PSU_v2.g1276.t1"/>
        <property type="gene ID" value="PSU_v2.g1276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic translation initiation factor 3 subunit G N-terminal" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1276.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23136" checksum="F22CC8ED5DDED2BD" modified="2023-02-22" version="1">MCRQLENYGVDIDNDALQTEIIDKMPPGEKNELNWLQIKSENVTTEMLLENMKDIALKAEISTQNIFSTTITETYSPTSKTTMNDDEYCNSRKKFACSLCEGDHWTANCPQFTTIDEKVRQLKLKNYCSKCARRSHNATQCRSSVHCNNCDGQHYSFICPERMNTTLRKVNNSNTLVALGTQQGCLLTKKITVMNPDTQNTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ43</accession>
    <name>A0A914XZ43_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914XZ43"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11801.t1">
        <property type="protein sequence ID" value="PSU_v2.g11801.t1"/>
        <property type="gene ID" value="PSU_v2.g11801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000002">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11801.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14255" checksum="F769C919A1EE6851" modified="2023-02-22" version="1">MGGSASTITRHAGRGRTHKMVFVANMGLGMGKGKLAAQVGHACLGVYRFAMNSSEGKDAVKSWTRLGEVKIVVKGNTTEHLVELYKKAKKLQLYAYLVQDAGYTQIPAGSKTVLAVFGLVEDVDQVTGDLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZE5</accession>
    <name>A0A914XZE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11903.t1">
        <property type="protein sequence ID" value="PSU_v2.g11903.t1"/>
        <property type="gene ID" value="PSU_v2.g11903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053321">
        <property type="entry name" value="IPP-5-Phosphatase_Type_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47039">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47039:SF1">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11903.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28362" checksum="615F31C1EBEA94CE" modified="2023-02-22" version="1">MLKRVLGAEYQFVASNAISKPFRTKGAIAICFRILKTSFVFISAHFSHGNLRNRILDFRKASTAFNFRATLSPHSPIREDHSIFNADHVFWFGDLNFRLTHRLNSDQLAREFGNQLFIQRNTFEKLLEKDELQKCISTKLAFHDFKEGIISFPPTYKFAVGTQTYAKHRVPSYTDRILFWCKHSDNIRPIRYDCVWPITVSDHKAVYGIFSVRVMDPHRSFSSNVASLDIITPSNPITEQILVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y052</accession>
    <name>A0A914Y052_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y052"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12596.t1">
        <property type="protein sequence ID" value="PSU_v2.g12596.t1"/>
        <property type="gene ID" value="PSU_v2.g12596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12596.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15464" checksum="E76BD4E6953938D7" modified="2023-02-22" version="1">MFESGMKEAEENKVIIEDFSFEIVEAAIKLCYHHSLVTNTTLNEKMILLQFFDKYNIQSLKENLESYLISEINESNVCLLTNCSLLSNASKLEEKCTKFLRDCFKSTKPICDVDVLDKNFALNLFKNAFCHLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0A1</accession>
    <name>A0A914Y0A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0A1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g113.t1">
        <property type="protein sequence ID" value="PSU_v2.g113.t1"/>
        <property type="gene ID" value="PSU_v2.g113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003430">
        <property type="entry name" value="Phenol_Hydrox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02332">
        <property type="entry name" value="Phenol_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g113.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12266" checksum="AA238745FDF42424" modified="2023-02-22" version="1">MKDWYVFRDPRQFYYGAYVQNRARMQESAETNYGFFEKRELAQYLSEDVKAKVTRLLLPLRHIEQTANLNFMSGSAYGYGTTITQACLYAGMDSLGMAQYVSRIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y184</accession>
    <name>A0A914Y184_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y184"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12545.t1">
        <property type="protein sequence ID" value="PSU_v2.g12545.t1"/>
        <property type="gene ID" value="PSU_v2.g12545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12545.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21373" checksum="91F69997FA70E6AB" modified="2023-02-22" version="1">MDVIERNNRTKETARRRSVVEEEKRIKYDKILQIKENREEKAAEKRKQEIQRAKEKAEVKNQRVQAVIAEKKKAEKNDCSDGYRCCRSSFVNNTQLASNFHHSLPCSVHQGNYGNNADSRRYSMDTLSAQLLKKAQKSSSPTHSSPQKTKSVANLQKLFEINLHIQKKSFQHQKTCKKYSKCCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y275</accession>
    <name>A0A914Y275_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y275"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12884.t1">
        <property type="protein sequence ID" value="PSU_v2.g12884.t1"/>
        <property type="gene ID" value="PSU_v2.g12884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038056561" evidence="2">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12884.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="29273" checksum="63390C6E3486EE58" modified="2023-02-22" version="1">MIWKCVILLFATVCFVTPEHPNNFSSNAEVTRIKREDDYEYKDYGSVEVPKSKILLFTIVLWTSVILIVVQTLVTIYGPHLPDHPLRWHTLNYSCWNCFQLIVFANCVEESEFKTFLYNSYLTENCEPIQKMTLTVYYQSMFAVAPIEILMYFVPESKGWPITKYYFWIPFMAALDFGLVLTYCSEPWGWWSNGYAPIDTYQACITVFNFVFVVILFVITICLIVKFCYYCCQYNARPDAQLWKVNSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2Y8</accession>
    <name>A0A914Y2Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Peptidase M12B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g12139.t1">
        <property type="protein sequence ID" value="PSU_v2.g12139.t1"/>
        <property type="gene ID" value="PSU_v2.g12139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF278">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="19">
        <location>
            <begin position="279"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1581"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1623"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1586"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1628"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="active site" evidence="14 17">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="354"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="383"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="401"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="439"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="597"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="601"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12139.t1"/>
        </source>
    </evidence>
    <sequence length="1653" mass="188996" checksum="39C0AE5E40D8EF12" modified="2023-02-22" version="1">MEPKQGVVWHLNTHEIKRHRQKRFIHNNENEEGKRHTRVIGLAKQCGYSCTFRLKSDFINPLSDIINDKKELKVFFERWQQVAKPVSKKNRDIINGQVIPLIQYMDNDEETHARLSKVSPDCLYTASVDGTDEKGIVNLCEKHGGLYKGIKGILCLNRSLQDEYPRELLLFSLSLFFASKQCLFGTLALPDGAYLIEPFESTEFRVHQKAYDLPQEFDDDKNANLEAQPRTFDDPIEKTKVNNNASYNNVEKTYENNTDWIDITRRNQRSRRSADSWDHYVEVLVVADNKMLRYHQGNLESYVLTLFSTVASIYRHPTLRASINIIVVRIIILKHERAGPLISNRAQETLQQFCAWQQNYNDRNDDAISHHDVAILLTRHDICRATHKCDTLGLAELGTMCDIQRSCAIIEDNGLSAAFTIAHELGHIFNIPHDDERKCGQYMQLNKHNYHIMAPTLEYNTHPWSWSACSSAMLSKFLDDSRAQTQCILDQPIERKYYDKMFENPAPGAMYDVNQQCRFVFGPAAEICPYMPTCRRLWCSTYYGYQMGCRTQHMPWADGTPCSDNKWCHRGQCVGMAPEQRAKQDGAWGEWKPWGDCTRTCGGGVQKALRDCDNPKPMNGGKYCVGQRERYRPCNIQECPWDTPGFREMQCAEFDNKNVGIHGVPMKTTWVPKYTGISRNERCKLYCRVIDSQAFYLLKEKVLDGTPCDQNGDDICIDGTCHKAGCDHRLGSDMKRDICGICGGDGSTCQTVEGVYNERGSFGYNEVLKIPAGSANIDIRQNAHNRNKDDDNYLALRASNGEFLLNGQYQVSVFRQQIPIQDVVLEYSGSDHPIEQINGTGPIRSDIYLHVLSVGNLNPPNIHYKYMVPRNNIGPAYHFPTSNYYWRFSDYFTECSSQCQGSQDRLLQCVDATTNRHADERHCTDRRPPPQKRMCNIDCFIKWKTLDASGCSSRCGHGEKHQQSVCIKSYNNGHDDTINEAECQKAKVAKPPSRVPCYNDCTGRKWFYSDWSACSESCGSNGISRRTIRCVDDANRSIDERHCERISREPLEQECNRVPCPRWAYGHWSECSRSCDGGVRVRHAQCQSAAGQDLNANYCNASEKDNRQKCNEHTCTAWKFGTWSGCSVSCGTGVESRTAECMDSRGRTLDDGHCGLEKKIVQKHCNRPECPHWEQSSWSQCSVSCQDGWATRSVYCVDSLGKKVRDEICLKMNSTRPVSHQPCNHGPCPFWRSGEWSKCSSTCGHGQRIREVECIFREQTVDFSLCPETQQPKAREICKLMPCTFWQVEPWSACSTNCGKGIQRRAVKCMRENANKYQVEDHECSQHLKPRSEKPCEREKCKDDTAKEPSRVSKIYWATGPWADCSSSCGDGTQKRQVLCHDHVRQLPDNYCQHIEKEPNERACNVKPCAKWTVGPWLPCPASCGIHHLQQRSVICTPTESASSKSIEETDCDIETQPPAMRNCGLPACPKEPVIVLGKWVAAEWQECSVSCNGGWRRRSVTCDKKVCNEKDKPSQFERCGEQKCTKAAWQITPWSTCSVTCGNQGTQERSIWCQEDINSKQRLEDFECVKHEPKPITRRGCASSPCPTKNQSAPIGPAKTNSVEESLKKYYSWEPGKWSTVRDENRRKHGKHHNRHNHYHYDVHYRRRLRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y454</accession>
    <name>A0A914Y454_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y454"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12523.t1">
        <property type="protein sequence ID" value="PSU_v2.g12523.t1"/>
        <property type="gene ID" value="PSU_v2.g12523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12523.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28941" checksum="5EC3A026E89737A7" modified="2023-02-22" version="1">MGDSGGNEQKLSELTMNGLSNNNHSVNGNSSSSAAAPSHHQQVILEQERFMPIANISRIMKRVLPEHAKLSKESKECIQECITEFFLFVTSEAAEKCNAEKRKTITGEDLLASMETLGFDNYLLPLRALLKKHKEATRSERPPSDLDESIENHGDHLRSAYASPPSPIHLIEDYRQQTFVLQEAETINHHQQQRQQQQPQQQQSQQQNQPQEEDIDDIINYLPPNFRRVTEIYVDTITEQHYISATSPGASSNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4K2</accession>
    <name>A0A914Y4K2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Battenin</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4K2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15125.t1">
        <property type="protein sequence ID" value="PSU_v2.g15125.t1"/>
        <property type="gene ID" value="PSU_v2.g15125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15125.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22173" checksum="8E0DC5DE8A5E9B8D" modified="2023-02-22" version="1">MMIPFLGLIVGDINYLIQTVYIYNNVYYLMISDIIYGCCGAGTALTGTTLSYNIKTTSPEVKSERVAAFEGAAGLGITLGYILSGSIRQYVGYSYYFLILMALHVLGFLYILIFAEELESSVSENDNEAVNVIPLTSAISSHFTQVFDFIKSYRNKLCFKYLIFVLICISIEMLFNSGVDDILFSYLRYKLSWTVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y517</accession>
    <name>A0A914Y517_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y517"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14530.t1">
        <property type="protein sequence ID" value="PSU_v2.g14530.t1"/>
        <property type="gene ID" value="PSU_v2.g14530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14530.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24739" checksum="B095E1A27D0764D6" modified="2023-02-22" version="1">MNLLNSEDDEELSYYTCDEGSSSDASTDDDDEEEESICNNDAVEYADETEEEEDFMLDYTENETDLNIIERDFNLVMSFNDQNSNVEERQKVLRLEYLPEEMDYLANEVSAVIGYSLDICKVLLHFFTWNRHKLLEKFYECDSAEDFFKLLKLQLPILSSSPSTIDGDCLICFETTSLTSLSCKHYFCADCWNYHLVTRFRQESDPYPFCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y533</accession>
    <name>A0A914Y533_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y533"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14544.t1">
        <property type="protein sequence ID" value="PSU_v2.g14544.t1"/>
        <property type="gene ID" value="PSU_v2.g14544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14544.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32685" checksum="D55728B0548F89E4" modified="2023-02-22" version="1">MPLIHKENCVFSSFDCPKLETSIAKLSEKAIKHMSDAVRSDESFRRHRRKPLTSSSLNQSTNMPLKNKNLKITDNDQTTLKKAKKAAIKSPLKSLSPLAKAIGKRNNGAVVIKNLMKESMECLPSTSHSTSKDIKNKNKMDRLDVKNMFKITRPEFQQFDEYKNDKDICSIPPFIKCQQIVEIEEEDEHFDQKKQKIKTDPSTSTKREIYDAAPIREMRRGFQYKAEKEAFCVESTTKWFARWNEPIQVENTTIKSQTGASHYESTFSKTFKNFIVQRKFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y534</accession>
    <name>A0A914Y534_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small-subunit processome Utp12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y534"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1281.t1">
        <property type="protein sequence ID" value="PSU_v2.g1281.t1"/>
        <property type="gene ID" value="PSU_v2.g1281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1281.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26205" checksum="C01B72097E0BEBCF" modified="2023-02-22" version="1">MATSGGTSFVVLLSQGIVGNDEEKIESVVKNSDPATVLATVKNLPVIHVIPFLNILEQTFRRDKVKQPHVWMNWVQAVLSIHMGYLSSVKDLDQKLGSLSDWLKKRVSHLDKLISLNGKLEMITEQMERRSKPTFFAQQQPLFILNDDDRIDSDADEILFEYPEDDNEEWWGSNDEEEEDESENEDKPKKIKRKRAAEDAGEDAHMKNGHRVSNGFGEDIDMESDEDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5N4</accession>
    <name>A0A914Y5N4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5N4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15508.t1">
        <property type="protein sequence ID" value="PSU_v2.g15508.t1"/>
        <property type="gene ID" value="PSU_v2.g15508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07385">
        <property type="entry name" value="MPP_YkuE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="245"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15508.t1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55019" checksum="FE5908FBAF8901FC" modified="2023-02-22" version="1">MSIDEPIAATADENASLTTEEIQDDSTTIKQQRHQCLRSRISNFCFNISANVPRHLIWILLLYNVCFMLHQIFFAHPGAPKLDMRRIIFYSFFTFGMLIGSIFIFKRIISIASKNRTKSWYKNGNIALNIFAYIWILMAHSIMIFVNIPLPETFFFPVICYLMLGAWLHCFIFLLIFFIIEKISACIPPLRKYKIFTSETLHTIIAISLAILLTLEGFISTSQAPTVKNLNIGIKNLPKEFDGFSIALVSDIHVGPTVNIKRVQKIVDIVNKLDSDVVTIVGDLVDGYVEYIGKRAKPLSRLKSRYGNFVALGNHDYLHENVEEWIKFFKNDLNLTVLLNSGVIFNKMESQLCLAGVEDYITETMHVEGHKLDPEKALRNCPQNVSTIVLSHQPNGAAKVLKSLPKINKHVDLILSGHTHAGQMFVTAPITYFSNPFFYGLYYFRETDTQIYVSSGVNFWGPPIKMFPSLCEIVNIKLRRTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6X7</accession>
    <name>A0A914Y6X7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6X7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15206.t1">
        <property type="protein sequence ID" value="PSU_v2.g15206.t1"/>
        <property type="gene ID" value="PSU_v2.g15206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF25">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15206.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29282" checksum="6ABEEB2FE197D2EC" modified="2023-02-22" version="1">MASLFSGYLVNKTSNTKPALIISRILAICSTFIYFGIEFNATSAIYLMIAYQLLMGISFGFGNVFRTHIAMATKESERSKGYGLSNLSYSLGTIIGPLLQLIFSLIHFPGLKLLFGLHFNLYTASVYLALFTSIIGLLALIFFFYGNLKVLPKKAGQDEIIVATENNTSTINLKEAGEIKIDKIDKNIKYDKIAVCVLIYAKCVHETITLILFSIPERIALMIAIGLFICFFGATFPWPFISQKIPYEHVQNGTAFFKRNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6Y2</accession>
    <name>A0A914Y6Y2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6Y2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15211.t1">
        <property type="protein sequence ID" value="PSU_v2.g15211.t1"/>
        <property type="gene ID" value="PSU_v2.g15211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15211.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20587" checksum="EC0184D7B4391C9A" modified="2023-02-22" version="1">MVVPRILVPSKNISPFFYRNLHSIKKFEIPPRLSVHNGFLLDSRPEGDRKVINPAWKPKSGKNLLRIELIDRKDFGLIGQFFVYQFIKHSNFCRHLQMKYEDLEPFFFELLDNIIDKPLSFAAFDEDKLVGIKLNNFHTADEFPELFPEGLYERNPKYEIKKDYGDSRFFSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y746</accession>
    <name>A0A914Y746_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y746"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1603.t1">
        <property type="protein sequence ID" value="PSU_v2.g1603.t1"/>
        <property type="gene ID" value="PSU_v2.g1603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1603.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14753" checksum="8B06F0A46F12DF82" modified="2023-02-22" version="1">MYSIKKRFFKNINNTAANALRLLSDDRRKCTEDLDCSAFDKCLQGICSRPAKTAHQNATQDYKCSAICVGGPVKPPLDCYISLPKCKYDYECQFNFFCIDEKCQRIGNHWPDESDIEKKKSFLSVIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8A4</accession>
    <name>A0A914Y8A4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="14">3.1.3.57</ecNumber>
            <ecNumber evidence="2">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Bisphosphate 3'-nucleotidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Inositol-polyphosphate 1-phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily. CysQ family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="14"/>
    <dbReference type="EC" id="3.1.3.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y8A4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14982.t1">
        <property type="protein sequence ID" value="PSU_v2.g14982.t1"/>
        <property type="gene ID" value="PSU_v2.g14982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050427">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01638">
        <property type="entry name" value="CysQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000005">
        <property type="entry name" value="3'(2'),5'-bisphosphate nucleotidase CysQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02095">
        <property type="entry name" value="CysQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006240">
        <property type="entry name" value="CysQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01331">
        <property type="entry name" value="bisphos_cysQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0452">Lithium</keyword>
    <keyword evidence="8 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14982.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="27882" checksum="1EAC840EDC1794A2" modified="2023-02-22" version="1">MIKLTTDLRETAIAIAQEAGQAIMQVYADGFDVQIKDDNSPVTAADLAANQVIELGLRQLTPDLPILSEESAQVGWEQRRHWGAYWLVDPLDGTREFVKRNGRAGLGVVLAPVTGIVWHAMRGELAYRRQGLHDTVLRTRTPATAPLRVAASRSHRSPETEALLARMGRIETIAQGSSLKFCRIAEGGLDVYPRLGPTSEWDTAAGQCVLHAAGGAVLSAATGKPFRYNRRETLLNGDFIALGDTSLPWRDWLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8L0</accession>
    <name>A0A914Y8L0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8L0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15094.t1">
        <property type="protein sequence ID" value="PSU_v2.g15094.t1"/>
        <property type="gene ID" value="PSU_v2.g15094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12880">
        <property type="entry name" value="SPRYD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035766">
        <property type="entry name" value="SPRYD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951">
        <property type="entry name" value="C13ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951:SF2">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="1">
        <location>
            <begin position="66"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15094.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21616" checksum="CDB57299DEF5F0DD" modified="2023-02-22" version="1">MNPFRACLECFQGPSFSATESYAHLREEVHCVKLDTNFMGNEVVLLKAGTRICGAGGALATAPIVQNKAYFQVTIQQSGIWGIGVATRSADLSKSPVVENAYMLHHDGRVISNGEEVGTITTPMNEGDSIGISFDHIDLKFYKGEEELPITIPNIRGQVYPCAFVDDNAILDFKFRTFDLHPPLGYEEIMLEQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8W8</accession>
    <name>A0A914Y8W8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8W8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16631.t1">
        <property type="protein sequence ID" value="PSU_v2.g16631.t1"/>
        <property type="gene ID" value="PSU_v2.g16631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="912"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16631.t1"/>
        </source>
    </evidence>
    <sequence length="1217" mass="128525" checksum="0ED97A0E5126B2AD" modified="2023-02-22" version="1">MPTEVSSTSVPVQTESTVETAEKLTTISPIETTTLEKSTESVPIIVGIVGETSATPTVKEQLAETTRSFLSETPSDESIVTGIETGSPTSASADTTQNGNTESQSHPSTERIETTQIPVIIEKLTSSSEESNDATTPILILTENVTNVLLENASIVSSVTTSPEDSTSQTKDKISKESTTHSSEAATASTMPVEIISSTKIPVVVVVVGTNQDLPETTTIAEEAISGSSKTTISNDATTVAIPLQTKEVATDVPIIVASENSQSETTFKLETTEAIETTRVTVPENIVSSNSNTAENQDVTTVADIITEPSTTIFIKEIIVPVTVASVEANIVTTTTSNNDETTISSDQTTLASENAETTTPKPESIIILPIEGSKNVASTTAQPKDVKTTLSTVLSTSASTAQNIEIETTEKQVVEQSTSNPSSAEQKTLAKVADIIESQEQKSESETSSTTVNPVDVAVLNVDDTLKNEDPKEATTVSNVDEAVAKVINFLNKNEISTTAGADETTTAVPEGERDNAIKNMLDRAKEVVKIPSTSSTEEPTVTKNFVIIKAENENETQIRLEPEHVVGVSNTSVANATELPLTTSEAVVLSTTPLAKIIVTEITQQTPEPAATENVRVVGTTQLPVSEGAEVAVVTEIIPKSTEFEITSAKKSATTLSPIVVELNEDVAATTISNEAVINDNTRTSLEAILSTKIVPIEAVTESIQTTKETLITVTEKMVESTTLINAENVTLDSDIPVEIPVIPIVGSATGFTEGIQLVGNETKSIASTTTEKAIISQTGSTMSVTEQENIEATTFASKPESIVPVVIIAAENQDKNDAIVLTTTISSSIPEEAVNTDISEEVTTPVNTEATTLEAIIQSRTIKTESEVVPIVVVVPESPETKEEIKETTIKTESITEVEKIEASTPLSTTVQTSEESATSTSENASINLLPSTSASVEKSENIDVISVVVSKEPRIIETSSSSISSAEQTTTILPEITRAPEVEKTTVVETETEIPIKTSSGIIAAIIAHGSTAPNVDVETTSSTPSVSNQTINSKEELPASTSSQIILTKEETTTQTVPIIVTNVEKTNATTIVSESIELTSTGKPIPITPLENAPTAAPIASLGEEQIVVEKSTTTEPRPETVTEIRITTIKIIEETTVTSESSTEQPLTTKQNIVPVVIPIEGKTPAPETTIIAESQTTIVPVSAQSIDDTIIVAKTIQPSEAETSEHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9T9</accession>
    <name>A0A914Y9T9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9T9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1620.t1">
        <property type="protein sequence ID" value="PSU_v2.g1620.t1"/>
        <property type="gene ID" value="PSU_v2.g1620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000005">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="97"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1620.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21368" checksum="56A139D53FA85044" modified="2023-02-22" version="1">MKLIESSDVVVFPESVTFTLSNRVLSVKGPRGTLKRDFRHASMDLTREGTNKLRVRKWFGISKELATIRTICSQIKNLIKGVTMGFRYKMRSVYAHFPINIALQDKGSLVEIRNFLGEKIVRRVQLPEGVLAAMSTKQKDELIVEGNDLELVSQYAARIQQSTSVKNKDIRKFLDGIYVSEKTTVTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEN7</accession>
    <name>A0A914YEN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17924.t1">
        <property type="protein sequence ID" value="PSU_v2.g17924.t1"/>
        <property type="gene ID" value="PSU_v2.g17924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF36">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17924.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28729" checksum="187771BCB730C5CD" modified="2023-02-22" version="1">MWVYFQNFEEVDDLLQECKGTEAYQLLISMKNNSNQNDVGLNWRLGQACYILANCSKEEESRAFVLRGHGYIVQAYEKAPRDTNVLKLAVVLKNFMYSNAIGIKERLKHRHEFKKYIDEAIEHLPEDFAFFHLRGRFRYEVASLSFIERGVASVFFATPPSATYQEALDDLLKAEEMDSGAIDNMLYLGKTYKALGNDAEARRWFIKSNKIVNCGINLGGSQETLNLYWLHYLDCLDWHDDLDSLIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEQ1</accession>
    <name>A0A914YEQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEQ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15869.t1">
        <property type="protein sequence ID" value="PSU_v2.g15869.t1"/>
        <property type="gene ID" value="PSU_v2.g15869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF18">
        <property type="entry name" value="LD43650P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="149"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15869.t1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38662" checksum="E220E604671E8A75" modified="2023-02-22" version="1">MAAAAVPLHTEVAPLVFTQLEEERVRDYFTKLVAKTATGVATHPLTLAKTLFQLGHEPYPLSTGKVLVFFGREAYFLPNAFQYLKNLYNEAGFTTLFTGLDAAILSSITGGAASFAMEIYLDRYFPDIGGAYQETKKEEEELTDHESFRLKLRQAIRASIFTSLGLIASRPLTVVMIREIAQLVGRETKYNSVIGALYTIGYEEGPRGYFSGLVPALIAQGITIWGTFALTYAIERGLVRATRDNHDDEHARKAFKDARKVFNVIIPFFVNSFSYPFSVVSTLMSLNGSGLAVSLLPYSPAFSYWGDLFDYLKPHGLVRGARLFLREQKGAVSVGANHHIYASNKHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YET7</accession>
    <name>A0A914YET7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PARP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YET7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17974.t1">
        <property type="protein sequence ID" value="PSU_v2.g17974.t1"/>
        <property type="gene ID" value="PSU_v2.g17974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17974.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10370" checksum="21E930B19F3768AA" modified="2023-02-22" version="1">MMENWYHETCFWEKASIDGITEAKVSGLETVKSEDQSKIRKKIVEALKNGQKESSGSGASKRKNDSSKNEEVSQKKSKKADVPSSSSSSKGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFJ8</accession>
    <name>A0A914YFJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18227.t1">
        <property type="protein sequence ID" value="PSU_v2.g18227.t1"/>
        <property type="gene ID" value="PSU_v2.g18227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18227.t1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34430" checksum="C423E70DAD2690C2" modified="2023-02-22" version="1">MSTFMLGSMIFTPILSQLADRYGRRITYLLPLWITVIANVGCAMAPTYTIFLICRFIAGVGTAGIGTIGFVIILETVAPAFRSHTPLVSTIIWVSGYCTVGLVHMAFQSWRVQYFILSAPFLLTFSFYWLLPESLHWLVTHEKHDGVSKYIKRSTKYNRRQIDLEICRSSTSPSLVTEGEGEGEEILESSSIKKSSTKDASHRNFLDILTHLPMLFQLSSHCFIMIVMNFTYWALSLYSTDLHENKMVGYFLSGLVELPAAAAIFALAYIGRRSVTSMALLAQAFAMFIACFFPGKFNLIGIISIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG45</accession>
    <name>A0A914YG45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YG45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19273.t1">
        <property type="protein sequence ID" value="PSU_v2.g19273.t1"/>
        <property type="gene ID" value="PSU_v2.g19273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002134">
        <property type="entry name" value="ABC transporter ATP-binding protein/permease wht-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF93">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE WHT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="95"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19273.t1"/>
        </source>
    </evidence>
    <sequence length="715" mass="80776" checksum="84585A0D9B11E079" modified="2023-02-22" version="1">MSSEKVPSNWMSNSNDASFSAKTAKQKGTKTVGFSERTDMTQSESKSKMLVSAEEKTTIVPDMPETNVTTGKSPKVLVFKDLFVSVPMMEKRSFVERLQFWKKHETIRREVLHGVSGVAEPGEILAIMGASGAGKTTLLNVLTHRNLKSLEINGEVTVNGEPLTLGEFQRMSSYVQQADIFMGAVTVREHLIFSARLRMGRRFSDAEKIARVDQVITQMNLVKCQNTLIGQRHEKSISLGEKKRLAFACEVLTDPSILFCDEPTSGLDAFMAKQVVKALQDLAKEGKTIVLTIHQPSSQIFNMFNKLCLMALGEIVFLGPPKKAAGIFKQAGYPMCGRDNPAEFCIEKLASHEGETEADRKDRVVKIKSTYDDSNMGSLYQNRIYGSVSERRKKLGNQDVRESNKYAAGWFTQVLWLFVRSFRATLRDPLLLKVRLAQTLMTAIVVGVVYWDISKPEKDTILTINGFLFNCVRDCIFMLIFPCLTVFTDEMPVFLRENHGNIYRTDAYFIGKNLAELPQYLLLPIIYSLIVFFMARVHEYTAIQFFIFLGVNITVTNLAVSIGYAAACIFGTTEIATQVLPLITMPIMCFGGFFVNLKRISRALHFMQHLSWHRYAFEIQMINKWEPAKDDHIKSCPSNEIDSLNSTKYFDEKIASHETIKECDWGNSGTAILDFFSFGKESNEMLKNFGVLLFMIILFRTVAVSALFIRARLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGR4</accession>
    <name>A0A914YGR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g195.t1">
        <property type="protein sequence ID" value="PSU_v2.g195.t1"/>
        <property type="gene ID" value="PSU_v2.g195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF15">
        <property type="entry name" value="AT02057P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="4">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g195.t1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51206" checksum="6CB8F3FB21786C9D" modified="2023-02-22" version="1">MLVDYSEHFWGEKHIGYNTLYENLKRGEDSVQELSSFVKDRISLEEDIFKSLNKSLIKVNQYVNNNGAFVDSWRLTKGTIELYCDIQASVLKNLIDLSKDVIKYHDDLVKSRKRVKVQDVVDAVNLMQTTTTCLQKAKETYQQRCAELLTMKNETQSKEVLKMKSKVAKAHEEYKSYVEKYAQVRDNFEEKMLKSSKSFQAHDTAHLQQMKTFFTQFGRSLDDAQGSIAQVTGDYRNSLQQIDIENIMVRFVEEKGTGTDKPEPIKWTESDELLDDISHITSSSQPSSSNSSAIVTNSAANLHQNVTNFIDLDSPSWTPTASTLEINKTGDSDIGDPSNIGASSNLTQFSSSLGRQKLSQWLPRRKKNSSQSSLSGTTEDSMAASTFGESNKGGFLKRYRKVKNSINDLTAMTENNKEMLNVDDNKSTASSAKSDEKVSCFFFSETLAHFWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGT3</accession>
    <name>A0A914YGT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGT3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18665.t1">
        <property type="protein sequence ID" value="PSU_v2.g18665.t1"/>
        <property type="gene ID" value="PSU_v2.g18665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="70"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="172"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18665.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35946" checksum="D814027AC745CDA9" modified="2023-02-22" version="1">MENKFQKVSSVEHKTKIASCHPPDGDGSNSAGIMKLKPKKPEEEDIKVKREKAKLKKKDIVKQRGNAADREIFVGNVASTVRRREIEQLFKKFGTIEKVWSRSVVGLSEKKTQTLVRKYKKMGSNVLDVINFYIRYKSPESVAKALEMNGLLFKGLHLRVTGVNKKSLCVGSSAFVSNLPFDITEEEIHQHFNECGDIKAIRVVHDRFSGLGKGAAFVEFSEKECVEKAIAMNGTTLKERELRVAKALKRKQLAKEAAIKSKNSKGKKKEAEKMQEKIADYVVQKKPVGKNVKIGKSAGKLGAKEKKFKKTKKGPVKSIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGU4</accession>
    <name>A0A914YGU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGU4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18546.t1">
        <property type="protein sequence ID" value="PSU_v2.g18546.t1"/>
        <property type="gene ID" value="PSU_v2.g18546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098:SF0">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18546.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18866" checksum="67B8D4C23F7A329A" modified="2023-02-22" version="1">MWSRNGMLRSVLAQNARPVYSLDWNNDSTKIAYCSGDLCFIKSLKAHTAPTKWKAHDGVTLCLDWNSASELLVTGGEDCKYRVWDQFGRPVFSSVNHNYPITSVSWSFDGELFAVGSFNILRLCDKVGWSHALEKLNTGSVYSISWSPDGTQLVAGSGSGHVIHAHIIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHA1</accession>
    <name>A0A914YHA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHA1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18170.t1">
        <property type="protein sequence ID" value="PSU_v2.g18170.t1"/>
        <property type="gene ID" value="PSU_v2.g18170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18170.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10417" checksum="4F49A9EBD2E45541" modified="2023-02-22" version="1">MSKFINLSAGKELSIMTPFDHPVDTHVVDKYFQAIRFDLRGEGLNMMPRYYEPSTFECKKVDQTFLYGVFYNDKENPGQEALLYYGVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHN9</accession>
    <name>A0A914YHN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHN9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16820.t1">
        <property type="protein sequence ID" value="PSU_v2.g16820.t1"/>
        <property type="gene ID" value="PSU_v2.g16820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16820.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9679" checksum="3472C42E558AED70" modified="2023-02-22" version="1">MFDKVTFPKAIHRHGQKHILSSNPSTSKSTEKIEMSESELEEVLTAASTSNSKDVSKVATAASTSNSKDVSKVPTAGHVSQLANLGKYAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIY0</accession>
    <name>A0A914YIY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIY0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19472.t1">
        <property type="protein sequence ID" value="PSU_v2.g19472.t1"/>
        <property type="gene ID" value="PSU_v2.g19472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19472.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8745" checksum="4C103671988671D9" modified="2023-02-22" version="1">MIIIFSILVYEWNRIHGITLSRKLRPVFNMSSVFATYKHLDPDNACLYAADKDKYYKWACCNVPEINSELPRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ27</accession>
    <name>A0A914YJ27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJ27"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17316.t1">
        <property type="protein sequence ID" value="PSU_v2.g17316.t1"/>
        <property type="gene ID" value="PSU_v2.g17316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17316.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14609" checksum="9817B5AE0E30BABA" modified="2023-02-22" version="1">MKKLESLLRIVRKRVSADRTLINVFNSYNNTKPDGFQICEVNPIVAKLIVVFQNAYSHLTSMIPIRDDSSSDNNCDDINDDGDNDIDEGNCNDDTVTDESLMDNKASLSDGSSICVSTEVGHIRGLEPGRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLG0</accession>
    <name>A0A914YLG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLG0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20386.t1">
        <property type="protein sequence ID" value="PSU_v2.g20386.t1"/>
        <property type="gene ID" value="PSU_v2.g20386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="150"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20386.t1"/>
        </source>
    </evidence>
    <sequence length="635" mass="70492" checksum="1085FDB3FA0BA5C9" modified="2023-02-22" version="1">MDSGLDGTSDSLTTLCERLRSEKLLTTSEISTLQNLNIELDGEISDLSKLTWRCEQEQLILRRLINSHASVGPENCCSLLANLDTVSFLEAYRRCGHHTSGICDILNILLKTPSAVAEFLYHSEKLNYSSEDLTRSIFNVLYGSGIFPSDEKRVLNVLAHLIKLQLISSSTDLRKILRKGTNAFSRLYSLLGEQLLSAKVFLTAAFHEPIMSLLAQDELYLDIEPNKSPLRFPIEERRKRFGGDETSAGYQEKLGSYRIMIVGRITKIVNKFVVSLQQSMSCFPPSLAWLVRKLYTTLLEKQIPESEARLICTDLVVTCFICPAITNPETIGVISDTPIGNIARFNLMQVGQILQILALLPYENPPNYFKDFLTTVDQTAMPNIIKTILNTDTLSLESMFPNVLSDDNGKELYKRQTCIGSLDEINTILAYLRSSAIDSISNSETKKIIKDSMAKMPQEFVSKSPQGKSPLNNSTITNGGTPIARPSSSSSTTRLRNFADRVQNAASRSHQRLMHSSPSRTNFSTPSSEGNGVAATPEMNNDDTATSMLDGADMEVLVFPLENDLSPLGLETEEKFMTTFHHHRKQNLSNKGAEKKTRFVATTTESVVSDRTNTDAASYDDDDDENDDGDGVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN36</accession>
    <name>A0A914YN36_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10 11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YN36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18741.t1">
        <property type="protein sequence ID" value="PSU_v2.g18741.t1"/>
        <property type="gene ID" value="PSU_v2.g18741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000011">
        <property type="entry name" value="small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18741.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8977" checksum="E93632C9DC341F9B" modified="2023-02-22" version="1">MSSIQPVNPKPFLNSLTGKPVVCKLKWGMEYRGILLAVDGYMNLQLANTEEFIEGTNQGCLGEVLIRCNNVLYVGAAEDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNR1</accession>
    <name>A0A914YNR1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZNFX1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2493.t1">
        <property type="protein sequence ID" value="PSU_v2.g2493.t1"/>
        <property type="gene ID" value="PSU_v2.g2493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="1">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2493.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38788" checksum="EDA2235A28BDE0D1" modified="2023-02-22" version="1">MDIHLTKVHVIISILNDLKGILNAEILYNLEGLKERIQDRYTTKTAEDKKEVIARQQYKRRFEEGAHGEPPENFRHLPLFPTTEDMNIKNVVYLRPAKIDGSRYDSDEHYLDVQFRLLREDLIRPLREGIAAYKEGGSKNFNLFVYKNVSLESAVLHKQTGELIFFANIQILRRMRTNKRLIYGNLVCLSPDDFNTKFLFATVAERNTLENGKVGLKFEEILEVNTKKKYCMVESPAFFEAYQHVMTALQTLPQTVPIPFSKYLVNAVTETKVPKYLSTNSINFEVLLKDPLELGKLIWDYELQNFYFQMIIYGDLVMINVQCWLYVTPIMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPJ4</accession>
    <name>A0A914YPJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21550.t1">
        <property type="protein sequence ID" value="PSU_v2.g21550.t1"/>
        <property type="gene ID" value="PSU_v2.g21550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21550.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10529" checksum="4F48208ADB0E26B2" modified="2023-02-22" version="1">MNYLHCKITPDVQFGGEKVYEVSENSIAYWPSQDVICPEIYGINIALRQMILEKVNAVRQKIQQGTFLLQNNLFALQAQNLPNLVSKFQSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPK6</accession>
    <name>A0A914YPK6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPK6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2094.t1">
        <property type="protein sequence ID" value="PSU_v2.g2094.t1"/>
        <property type="gene ID" value="PSU_v2.g2094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2094.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13808" checksum="D186278A76DF1897" modified="2023-02-22" version="1">MPPKPSGKGAKKAVKSQKTVRTGDKKKRRKARKETYSIYIYRVLKQVHPDTGVSSKAMSIMNSFVNDVFERIAAEASRLAHYNKRSTISSREIQTAVRLILPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPU2</accession>
    <name>A0A914YPU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPU2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2206.t1">
        <property type="protein sequence ID" value="PSU_v2.g2206.t1"/>
        <property type="gene ID" value="PSU_v2.g2206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2206.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30286" checksum="9BF866DEC16CACA2" modified="2023-02-22" version="1">MADLPEERLRPSKPFQFIGLDMIGPLNVKTHEKVKTWICIFTCLTTRAVHLEYVMNLSAPTFVQCLIRCFSRRGLPDQIISDNASQFVLASKAYIAAYPVEKLTWRFNVPLAPWQGGIFERLVAIVKNAFRRSIGRRCLGLEEFRTFICQVENTLNCRPITAVNNDIDSHNVLRPIDFLIPEFTDPSISIEDDRSDPEYLPPNVSSKVKLVKHWEKTLQHLHALWDFWTTDYLTLLRERMQSHHKGRRNQMKICRKLYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ21</accession>
    <name>A0A914YQ21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor AP-2 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQ21"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2917.t1">
        <property type="protein sequence ID" value="PSU_v2.g2917.t1"/>
        <property type="gene ID" value="PSU_v2.g2917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="254"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2917.t1"/>
        </source>
    </evidence>
    <sequence length="469" mass="50826" checksum="25F6ED0274E50197" modified="2023-02-22" version="1">MPVATEGGEQNNQIALANLLMQYYNYRNNNDETGTRLNTSIGINPLNGLTVETQPNYPTKSLVKIEMKEEMKSPGQATSSSSSSPHGSAGRSDSPASTVGSLPKEAEHADRKRPLAIQELLQSKKARLDKIKSVKPEGQTSEHPSPAPSASEGSHGGGLSDIIDRLARGDEDDSETTSSGGSTNGGAMPTAAFSPNVSSENNNSSILAALHSKQVVENNRSFSLTPQSRIPSSANDNGVLEHPVDGAIPLERVFAQVPGRLSLLSNVVKYKMTVGEVRRRLMGPEAFNFSLLGALLRRAKMPEKSQALVEELYSVGISIARGRRRMGTVTLLSALTEQESIQLAKDFRQITDKEFPIKNIAEKAFKDHFSSQIGQIKNAHDASMIVQERLKNLQKAKSVALEFMNLLDMDKSPVCDQNPTPVLEPSIQDPLSTYSMLTHGFGTPAVAVGMQTFFNFLEHQIESLSSKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQG0</accession>
    <name>A0A914YQG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQG0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3047.t1">
        <property type="protein sequence ID" value="PSU_v2.g3047.t1"/>
        <property type="gene ID" value="PSU_v2.g3047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3047.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19779" checksum="A89993DB6616EC40" modified="2023-02-22" version="1">MLQQLTLAKQINLPSNGRSLHHLEDDDSELRTYFAYGGILLILFILLLITLIQKRRQSKPLAANMLQFLKADEWELNESDVLIQFVYKIGNGSTAEVYRGKLSKDFRTPANGPVVLDESYQVAVKILKKNATETQKTEFSAEMEICKLIGRNNRIVNLIGKLYKKGYGDSKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRZ8</accession>
    <name>A0A914YRZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRZ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3520.t1">
        <property type="protein sequence ID" value="PSU_v2.g3520.t1"/>
        <property type="gene ID" value="PSU_v2.g3520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF89">
        <property type="entry name" value="COMPLEMENT COMPONENT C1Q RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="172"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3520.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="50404" checksum="6BACDBAD5932F581" modified="2023-02-22" version="1">MVLNLVAVNSVDVSLKKSGISVSDFSSFTSNLLQNENDEVSPKLGMGIDAVVELAKSHEVRGVNKVILIVSSDATSSDDALPSAEIARDEYEHKIMAISVRKPTTELLKDMADNSPSRVIHLSEWLGNNELFNSWFSYAICESIGSTSQPKSTTVTTKRPKQKPTKSPTAQEPSNINVIPISPTSFSVTWTCCTNNKADYVIIYTPDASLSIDKWKRIPARCRDSFGKVIDNLPSDSDYKVCVVTKTSANNNSAIIDDENCDSITLDKETTAPPDYEPWDQEQQTSPCQCLCSDDGSAVIQASCNKQAMEAFRPVATLPPAVEGECPCSVKAHAGRCPSGYFLQKSMCIDVNECQQQNGGCSHGCINTPGDFYCACPHGMMRDPADPKTCINVAGSFDRITELLAQYLHANSKSIDGHKVGVTSSDSDKGRRFKATIKTEDDKILSFEWPAMVRKALRWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSI4</accession>
    <name>A0A914YSI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3124.t1">
        <property type="protein sequence ID" value="PSU_v2.g3124.t1"/>
        <property type="gene ID" value="PSU_v2.g3124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3124.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="10413" checksum="2D79A313D7A2AFCE" modified="2023-02-22" version="1">MVVVIGVVVVVVDAAVVVVVGALVVVLVEVVARGVVLVEVVAVVVVVEVVGAKVVVDVVVGALVVVLVDVVVGAKVVVVVVVVVVVVVGARVVVLVEVVGFGVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT08</accession>
    <name>A0A914YT08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class V domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3295.t1">
        <property type="protein sequence ID" value="PSU_v2.g3295.t1"/>
        <property type="gene ID" value="PSU_v2.g3295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3295.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34735" checksum="C2DBF37C46D15420" modified="2023-02-22" version="1">MESKAFPSDHYAIESQIRLKGRKVEDSMICLSPRKGEDLIRNEDIIKYIEENGDSIAVIFFSGVQYYTGQVFDIEKITAAGHKKGCIVGWDLAHAFANIPLYLSKWDIDFGAWCTYKYGSSGAGGLAGAFINKRFGKDQRDRMLGWWSHRLSSRFTMDNVMDLDDGAFGYRISNPPIFLATGILGFLEVFNKTSMEELREKSLKLTGYLEFLVNYHLQKISEISKIRCEILTPKDPVQRGCQLSLKFNFDIAEVYKQLARRGIAVDKRYPYVIRVTPVHFYNTFTDVWRFVDQLVECIKEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT66</accession>
    <name>A0A914YT66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3354.t1">
        <property type="protein sequence ID" value="PSU_v2.g3354.t1"/>
        <property type="gene ID" value="PSU_v2.g3354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3354.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17720" checksum="41BC222DD3F75E9D" modified="2023-02-22" version="1">MRRISGTQTRTQREQQRKYMEKLTQARSKTVEFNEKSSLKLKKASRPTKLQLKSENTMFNKEHIKPPAIRRMGSSPRTGLMPADTYSPRRPSVDSESGSEAVSSSTPTTPRSPSQLQIPSVSLNGSKFQKHAYSTPVKKSFSVIGDDVFDENSIEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT83</accession>
    <name>A0A914YT83_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YT83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3899.t1">
        <property type="protein sequence ID" value="PSU_v2.g3899.t1"/>
        <property type="gene ID" value="PSU_v2.g3899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="8">
        <location>
            <begin position="130"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3899.t1"/>
        </source>
    </evidence>
    <sequence length="599" mass="68585" checksum="EB44A6CF612C561B" modified="2023-02-22" version="1">MTATDVFDRFHLYSFADRFIIEPRNKTGVLASDSYLEIDRNLGDFKLQRAHEHPIPIAEGDVMPIYGIIGIIRLVSGFHLIVIKKAELVGTINDSEVYHVTESAVIPYSKSTLHLTERQKWFQKHFQDMIQLVLATTGFYYSTSYDLTHSLQWLAENASPNFRQLPMMERANPRFVWNRHLTAPLSINPEFARYTLPIMHGFVGIRKCIVRGSSFKLAIISRRSIHRAGVRFYMRGTDLTGNSANFVESEQIVEFDRGQDPLQRTLTSMLQIRGSIPLFWSQKPNLRWQPLPCLRPADDQLDAFVRHMKLQQLNYGGKHVIVNLVNTKGREKGIGGELERVTVQANLDFVRYVGFDFHKECKSLNWDRLHILQAMLDKDILQFGFFYSHPGDPSRNRYQTGYIRTNCMDCLDRTNVVQAMFAKDSLRHQLIYLGIIDPSTQSLEEVPDFAYLFKNLWADNGDECSKQYAGTGALKTDFTRVGKRTVNGAMADGVNAVTRYFKNNFLDGYRQDAIDLFLGNVIVDPANLPTTFEESVFNFNKNGGAIVGAIFSAAMMMLCVLVSENITATLFWLLVFIAFMCFIYINGEEFVCRPRLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTQ4</accession>
    <name>A0A914YTQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Activating signal cointegrator 1 complex subunit 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTQ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4054.t1">
        <property type="protein sequence ID" value="PSU_v2.g4054.t1"/>
        <property type="gene ID" value="PSU_v2.g4054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="319"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="543"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4054.t1"/>
        </source>
    </evidence>
    <sequence length="745" mass="83980" checksum="14A27A177E42DC5C" modified="2023-02-22" version="1">MSKKPFNFFAGDAKKHTQESTRTNGTTAASSSSSSKTRNTVPENVPSPSLPSQSNGSLRTSIMEAIRTISNSDPALIESFKQSILELLLSERSIDAIQEDLFNALGVENFELISEILTQRDQVIQVLVDSSDGSNAAGEQYDNTRQSTPILDYEEDDGNPMSNFIVQTKSQSKQRKENRKDQKRAYREVNKVIAGLGETDKLEYQLALKEHQRRMERQFTEVEWTTNGLATRPRQLPYVFDAFEAAGLKSISVDSTKMCLPEGTEFKKTKEYEEIRVPPTSQTIPIEVKRIQVKDLDPLGKLGFEGFKELNIIQSIVFEQAYHTLENLLICAPTGAGKTNIAMLAVLKTIRDHCKPDGTIDKNDFKIIYIAPMKALAAEMTENFSKRLSKLGLKVKELTGDTTLTKKEIAETQMLVLTPEKWDVVTRKADDEELTSLVRLLIIDEVHLLHDERGPVIETIVARTRRRIQMAQHKVRIVGLSATLPNYIDVATFLDINPEKGLFFFDGRFRPVPLAQTFIGVGQSLDRTQQGQQKLFDDVCYENVLKYVEQYHQVLVFVHTRNGTHKIAKYMLEKAANQGQLEAFLPSNITIQPYLKAKKQILNLKNRELEQLFLNGLGVHHAGMIRYHRSTVERLFAEGHIRVLCCTATLAWGVNLPAHAVIIRGTEVFDQQKGVFTDIGVLDVQQIFGRAGRPQFETSGEGVIITNKSKLIKYVTMLIRQAPIESQYMKRIHDNLNAEIAAGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU44</accession>
    <name>A0A914YU44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU44"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4170.t1">
        <property type="protein sequence ID" value="PSU_v2.g4170.t1"/>
        <property type="gene ID" value="PSU_v2.g4170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="1">
        <location>
            <begin position="105"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4170.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27413" checksum="543CAB989B1E05FE" modified="2023-02-22" version="1">MSPSVACSEAFEECHSVILASGTLCPTETLKTELGLNFDFEMEGNQVIPDNQIFASVISKGPHNYPFKCTYKNMQDQTFFIELLRTIRDVCKTVPKGVLVFVSSYRILNDLQKFLRYENLQIDIEKHKKIFFEPNRSRDLKQMLEEYTFTIETAGSDINSFNGAIMFAVFRGKVSEGIDFTDDMARCVICIGIPFPNFTDELVVQKKAFNDLHSRSTKMLSGDEWYSTQAYRALNQALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUT4</accession>
    <name>A0A914YUT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUT4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3903.t1">
        <property type="protein sequence ID" value="PSU_v2.g3903.t1"/>
        <property type="gene ID" value="PSU_v2.g3903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3903.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16576" checksum="FC370A648E58443C" modified="2023-02-22" version="1">MRQQSSGKFTQNRRHQGNNNNINNNGKPEKVPQEKDYRIYAKCDENELRRRLIPEILQEFPERGLRLYGSRLPRCDQVLVKSIEAVKLNPLMAGNPFNANNRQFKIEKVLGPRSYRIVDLSTKTKYFLKLEAHGLPKAGPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV18</accession>
    <name>A0A914YV18_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YV18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3512.t1">
        <property type="protein sequence ID" value="PSU_v2.g3512.t1"/>
        <property type="gene ID" value="PSU_v2.g3512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000007">
        <property type="entry name" value="ATPase inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3512.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11868" checksum="725995EE88B1876A" modified="2023-02-22" version="1">MAQRQLVRPFLTTFRCMSGGEYGSGSGKGGGSGGSIRDAGGAFGKMEAAREEEYFHKLKQAQLKELRGQIAREIEHHESQQKNHADVIARHKKRIDELASEEANLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV28</accession>
    <name>A0A914YV28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3832.t1">
        <property type="protein sequence ID" value="PSU_v2.g3832.t1"/>
        <property type="gene ID" value="PSU_v2.g3832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="272"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
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        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
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        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
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        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
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        <location>
            <begin position="493"/>
            <end position="507"/>
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        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
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        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
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        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3832.t1"/>
        </source>
    </evidence>
    <sequence length="999" mass="112307" checksum="D950B23BE9ED79CA" modified="2023-02-22" version="1">MPATGRGSRGPPGGGGGGSNSGGKNHGKRRNDENINSNNHFNNQNASTSRGLQGGNRRGRHDFAYRSRGGNHQYYWNRSANNDGSQGDNKGKGDEMEKDHNKLTASQKKNRGPLPDWDEVAETGKEEVFDYMEMMEQQYAQLYAMSAQPFDPTFDPNNRINPSFPMGIRQQFGYGPVPFPMVPQPRQYVPNESHPTDAPVNAASSNEKSTEEHANGSRTESPDSSLTTSISHTPLLSPDPNQPVPIAVLPPMPPQRNIMIAPMFAPPFLPPPGEPATLKDSVRRQIEYYFSRDNLQKDFFLRRKMEPDGFLSISLIASFPRVRILTQDLNVIIESLKESRNVEMHENGFKVRPRETPHIWSLNAPGSPDMMPRRVNDHPHQRRIITIADPTSSKPVIDESEIVAKLSKSRMSAVSDDTKSTSSEEDRDKMSETAESNDKEQNVNFCETESGTVSDSKNDKSKAQEKINAKEASDNTSKNDNDVPQPHPKSVVPKSSVNESETMQSSKIGEKKDATPPASKTVNVSKSSEEMPSPSDSTAPPMTEEEIEEWQEVKIKRGKKAKGGSITNVVISNKKNNRVPDLDFKFDDEIDTEAAPSASHRERRTSSHSLKDEMSDANIDQLIIVTPNPAKRQYDRTGDFTKRSDRNQRLNEEMEHGLRRYEEELWCAEAKHDPSSTNSKVATVGEAEFEKIKRTNDERSKEVSSPTSQNGETELSSPRTPDSAVPKTPPGSSIWTQKAMERAAASAALPKSPVAKREAKEKPMARFYPLNNKDNNTKRSKKGKVTFAEPVAMTAMPVGWVLGTDKTPTKTKKIPSSDDNQHPLATLPSSHPSVILFQDNGFEPLVYSDWHDKCIKQRAAVGFDVSEMNTLYRFWSYFLRDNFNKNMYAEFRKLANEDVLAGYRYGIESLFRFYSYGLEKRFRPQLYKDFQDETLADIKRGSHFGLDKFYAFLKFCKISTQLEVIPQLAKEIAKYKKNDEFLTNPATVAKRELEIEFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV69</accession>
    <name>A0A914YV69_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV69"/>
    <dbReference type="WBParaSite" id="PSU_v2.g387.t1">
        <property type="protein sequence ID" value="PSU_v2.g387.t1"/>
        <property type="gene ID" value="PSU_v2.g387"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="RALGAPB_N"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ral GTPase-activating protein subunit alpha/beta N-terminal" evidence="2">
        <location>
            <begin position="250"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g387.t1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51352" checksum="83B318B5CE391EB4" modified="2023-02-22" version="1">MRVLSEYCDSCSGLNNKNVDRLDVLGFNPGPIKKTPILVNTQANSQPSLRERAQMLQVYLDKFLDYCHRETVKIEWNDESKQLDCAKFLLDRIIVLYIYQVFPDMEQNGVDIFEGWEGSEEIEDQLDTADPIVIARYWLIRWMTNISASTMVENPAPGLLIFRQALFSSQKATNTLLTLMRESMHTPLACANVVHKVLFVIRQWILQIEFPAFVERNTVSIEASSLLLIHIFTSFFKNPYLTSSGDRLSSAVSVTHSILSIARELSNPSNFPLPRPLSKVVWSELIKRITEAVAICSSRSDAFSRGTAGGFTNTLLSICVFICAIREIDIDDKMWDEIWIVFKNGIFWQQMVQQWSKVVDNVTRALILNLFAIDIHERSDDNSEGHGKRLASNRSDKSSENGSVNGNNGGGMYGNSDEETIIEPNSDKDIQSVVQIQLKHFILNKLFKQFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV91</accession>
    <name>A0A914YV91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YV91"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4513.t1">
        <property type="protein sequence ID" value="PSU_v2.g4513.t1"/>
        <property type="gene ID" value="PSU_v2.g4513"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4513.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="28106" checksum="A06ED4C41572728F" modified="2023-02-22" version="1">MRVVFMTPQVMGSPQSDQKASPRSIPYFNSRAIEERVLEYDDLTIYTSDLRSLQRNSWLTDNAIAFATTYLKNQLLKDFVAFDVIVFPPSIIEIIKFSHEDELPIKIDKMKFYFFPINDNTNPSISFGGSHWSLLIYDPCLSRFVYLDSMYMYPPTYVNKFVKKASSIMMLDNTAEVLSPLCPKMTINGNCGMFVIEYINIIFVRMLAGKQELYKFPQLSDEFISERRKYWLNTAYNLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVE9</accession>
    <name>A0A914YVE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVE9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3639.t1">
        <property type="protein sequence ID" value="PSU_v2.g3639.t1"/>
        <property type="gene ID" value="PSU_v2.g3639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF18">
        <property type="entry name" value="PAN DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3639.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21723" checksum="915AF994069B53CB" modified="2023-02-22" version="1">MNVCPDEKVRNRLMRYPVIEVEDGYSTHMKAFRFDGSRRVRIRCAVNICVDRCEAVTCEADRDFNSVLSFGKKRKKRQTIGDLQELLEKYHDAKLSGNVVLGEEPDADEGKSHGSTIEQSTISGIYTILEGTSKASEAKGNNASKLLIPMEQEVLKPISPVETTSFNRLNMTNKLASESSSESSTSLYECIGLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWF8</accession>
    <name>A0A914YWF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4892.t1">
        <property type="protein sequence ID" value="PSU_v2.g4892.t1"/>
        <property type="gene ID" value="PSU_v2.g4892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047171">
        <property type="entry name" value="BAZ1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510:SF1">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WAC" evidence="10">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="1106"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="868"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1156"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1186"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4892.t1"/>
        </source>
    </evidence>
    <sequence length="1257" mass="144608" checksum="8D0423563F50C74C" modified="2023-02-22" version="1">MPFRRRKPDPSIKDSDKVWYIESTNEVFTNYDDFFDRYIQMNSMCWTCPVTGKSGLTFEEAKESEREAVKAVEDSFPKALAVPLLWLAHTYCYRGRCDDLVNDVYVVSRDRYFIGETVWYQQSEAQRFKGRIVGVEYDATKAIAAKKDKKDLPKKEEHHSEDEDAANQSATSKKKSVIKPEDPEVPNPECYTYSFLPFENDGGDAITDIEHSAISRPKAVGSRVKMRLFMRKLTELRGNKVVLSKSTIEQYQLTGRHWEEFFTGPLPDFPKSERRKPFGYINENKRKAESPPQSPVVAKKQRASKSTGGKVKKEVQQQQDLLKDVFEQARSLQIEDLPKWEQNQRVLSDAEIDELKEAIKIAQEDKREREKDRKKLEKEAAAAHKRPRDDLQCDDLKPLPELKFLQLPSYLTPESFSQVLSISQFFYTFSNFFEDIEITLKDCILALYQNGGKNDSLVKILTALLKCRAICVEKEDGDEANPKVDNEMSNETYAVFNNKKHGGRIAELNKLHEKYRTLHGIAPPFLTVNWVTISEVLRLNLIISGYCPMGLVYQTRVSKRGAIQCYEDPVYAHLLEDPTIAEKLETLSIFDLTFDERMTLIDILREQLLTFCTFRDIQEERIVKLPDLRKQIKNLKLWDQEQEKASRIAAYAADELETPKNSKDKNIVKLRAYLKAVNENRRGVNPDDVKDEFLGNFPYDEFTAEEIRDFRDIQKTFFADKLEELAVENFETFCKIGSGFLGRDRSFRSYYYFEQYPIILVENVDNPGDCGEATPMKSDPDDPDAIISVMGCTGSAENCLVHSKSRPKWMYLGNEGDLDELINACNPRGFREIELVDSLTTFQKWLKPAVDNLSIVLQESANELKENHRNALDIEEENPLTNGHSEDIPMENGLDKSEPESRQTRSHSKSKTPDSTINNLKKKKNLKITFSSAAEFMGITDLKQTEDFQDNPLLFEVRKMITDMISKIDLQALGEFSFNDNQTSEEFLKALNNGENIKPFMVENDLKIHCYDEENIISSEEFDKLENSEFNQLMLAFFKVIHGVRQKFIKAPFTLTEKQRNNVTVIPTKAFVQWQQAIPECQSFSALALFITAFDSSVQWTAIKNTQKCPVCRKKTQAEDSVICDHCGNQYHMQCTPDEIESRVAWLCKACSRKVAPPKKRKPPSRYQEENDEAEKEAPPFVDANNFDEEEDEEEEEVAEKSTIDMDDVFQTSDSPPPNDDNNSSLENQEDGGGRNARVRRNKRPVDYSEYGESLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2024-05-29" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWG2</accession>
    <name>A0A914YWG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g2420.t1">
        <property type="protein sequence ID" value="PSU_v2.g2420.t1"/>
        <property type="gene ID" value="PSU_v2.g2420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045802">
        <property type="entry name" value="GRV2/DNAJC13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19432">
        <property type="entry name" value="RME-8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2420.t1"/>
        </source>
    </evidence>
    <sequence length="2285" mass="260658" checksum="3680B4CC1DA2D6A0" modified="2023-02-22" version="1">MTTFNPNNRDITCFLVWKHSWKGKYKRIFSIGTLAITTYNPQTLEITNQWAYSDFVGANYDSRATQTRQNDNDSYFLIHFKKKNKTENMKFSSEYTHDILTQMFEYEAKFAGRHIERMRYNSFKEGWTDKRTSVILQVAATTLFQLNQQAVVVAKYHFKDIKEIAKVSDCPGGFVIAVGDKLRRHLFASQSADKIIGEIRQNAGENLGIFIQMSKEDLTMDDFRLTRLGLNSKDELLTSYVEFRVQKQSLRHETPVRRIFCLSEKCLIERDIATYSPICARSLTSIVCLSRDLKDPQKFCIEYESGEQQEYSSNERDLILASLIDGSRASSNYQIFVMSRNFEKNLRILPFKYLLDEDGESQLMKHIINVPPGLKRHEMIRRFNANIPYNGLTYSTPNEGFFTENKGRNIVGCLEAVLAEVYPKDEADAAFKCEAQLSCLHRLFASKAGFQAFTAVSGVREKLGALVINVLKWNHEAVDHATVEMLCSLMQPMHANYELRLEQLNKKSLLSSKEFIEHLLNLVVTHVERGTGSLVIASMLDFLTYTVCYPYSETTPGDIFDIVLESVAERGRAFYKLFLNPSMTIVKGAGLVMRAIIEESTPDVSKFMQVLSLTEGAFLTHLQLALLSSGKDLRVLTNKQLSGHLIALWIAENSAAMDLLKRCIPRGLLDFLDQKGVKPPADETDYLLVRNNLEMATNETKKSALEMQLKSAKITVEAHLESFLNHWNLNQKLAFLERPKENDKTQKPVVLRKRRRQIKSEANWRLFSYYFIRDHAKADLIWNEKTREEFRHAIENELRILQQEIEFVEKGTLVSWNHAEFSVEYASLAEETKIGDYYLRFLLTENNAEATPIHDPSHFFNTVYHRYLLSPKLQMKCLCLKAMGVAYERHAITIGSFTDSKYIVAMLEKCTNPAERDHFVFLISKLVLDKNNARELIAAGVIPILVDLAILAHLHVSRATIPTLGKTAIEYQNTEGSQSREWYYHDEKEQRQGPLSFYEMKEMLNEKKITEKTEIWAEGYDRWFQLSNVPQFKWTICQENNTESSETTTNKSSQNASTLYSLTELCVVILDILIQMCSFFPSRDESDAVIRPLPKVKKILSEPVLLYQIVPLLLTYDSQIVQRVAALLLSVMEDNQYISRLYLSGVYFFILMYNGSNILTIARFLHYTHHKQAFRSNMRAFKSDLVASSILCHILPEATIFYLDQYGPEKYAEVFLGEFENPEIIWNTDMRRNMIDKLGSHVAEFSSRLTSNVKSIYQYTPIPPIEFTQLEEELFCHYYYLRHLCDEKRFPNWPIREPEIFLRLCLEIWYEEMEKKPPSMSLEEACIQLGIPTDDESWKNSELVKKAYRKLSLQYHPDKNKSADASEIFGQINNAYLFLTSKLVQRENTGLPDIQRIVICLRSQSIIYSRYCEELSELKYAGYTSLIKTIDLESKDDKLFNEGGGGLLIAAVELCSWTLRSSALNAEQLRRESGLEALYRTFERCIDTVTRGSKESDMVVQVCTHVCYCFATAARFDACRERISEMRLIFQHICHLLKFDHLHRLAVAAAECVCSFSVCTLLQTQLFQSGVIWQLLPHLFRYDFTLDEGGVSHSEDTNQQSILNKLARSSAEALACLAGFREDHPENDGVQRSLQAMLTPYVCKLMREGDNNAVLKVLNNNSENPYIIWDNGSRAELLDFVDKHRTSSIDSELFGAEFQLSAYGKELIVGDIFIRIYNLQPEFKLDEPKKICLDLLDFLREKVETITGFATAESKKPTLPAKPKPSQPKDENLIVDLSDLDWVDVSKNGNQLSPIEQGDMVLDALYNVLIHNPGIEIILLGQFSLIFQFLRAHQHSTIQTKTLNIISTAASNKECVSDIAASFQLGSMLVLISRLQKSINTIFQTLIALSSNGNIVKALLDYGGLLYILNVFCDPQLPTENRIHAAELLAKLQSDKLTGPRWVRYLIRYLPPIFADSLRDNSSNAIQMFDSTTESPELIWNDEIRKAIRQNIQKSVSELSALHLSDPGAKWNAPNTEETLYQSVVEGEIIVGGVYIRLFNTNPSWTVRHPKQFATELMEKVLELMNTPNDFLEPVTTALCSLIQYNKAIADQIPAQGYLPQFCTAMTSSNSRASRTALLILNELATNDYCAESLSVQPVIKGIHICMKQQPSLIGEAAHALKFLTKKTSSELAQQFLSSKIVPFLLELLGSSLPEVGNPGAAKAEMVDALKQVAKDLQYGQQITEILEKSPIWAQYKDQRHDLFLPASRTQAIAGPTNVGVAGYLTNSMFSPPPTDRDKPPERNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX64</accession>
    <name>A0A914YX64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2679.t1">
        <property type="protein sequence ID" value="PSU_v2.g2679.t1"/>
        <property type="gene ID" value="PSU_v2.g2679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903:SF8">
        <property type="entry name" value="MAX-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903">
        <property type="entry name" value="PLEKHH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="143"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="6">
        <location>
            <begin position="308"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="5">
        <location>
            <begin position="472"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2679.t1"/>
        </source>
    </evidence>
    <sequence length="795" mass="91483" checksum="2C0FF2D57E1E2704" modified="2023-02-22" version="1">MRHQRQHQDMASPCLRQAEMNGYLVAMSDNRLKSLKRRYVVLKNSEMKFYRTQKHLVRDENPTMTIKLRDVKNISKVSSKSGGNGFENIEINPFLFFTIFLNGESHKLQAEADKITDEWYNTISQQLKTLTITDFAQRLFPFDPQISGWVTKVKNGHQKRYFTQIIDDKLLFFKKPDEKIPHSHQNLRGARISEKCKSSSDEYSSSSGDEQNEIGAIRGSANCSSSASAIYNGCSDSDYSICIEAVDSDPQYLILRTSEDKDRWLYYLRLAARDASIRGTPFEILIERLMAESNPLDSLLWHDLLFKTVEEHQTETITTIDNAEFKKKALEIDLACYLFTAVQMRPIAIQYHVDLSQNILTKALQHESLQNEIYAQLIRLTSGSMEYGYQAWKLLSMAIPLYLPKQYSLLWLLRHHIERTRKDGVESEARMAEYCNQALSNRQKVGDRLEGPSKLEAISILTRDPMNTVLPYSIAIRLPTGDHQVIEFDGSTEIGQCLSSLCLKLGIRPALLSGYALYANDPMGSSDDLILLKGKQKLCDCLTLWERQTKDSKTGRVTADACSIKLQLRIRNYWGSLSDDETATERLFLCQRLGEEVVAGHLPLSNDLAEELCALYAQMCYGDASEVMDEKLIDEILSRFYPTKLLEVANRRSLRLSVHQQWKNLLQSVNVTECVRLILIVLRKWKFFGSYVKEARQKIDDKKIFIAINENGVHLLSDQLESLKSFPFHRFISFGEYHGDFMITVSRILQPTSHPDESTRERLTFNMEKKAIEQITTHLAEYIRCQKLLWKISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXH3</accession>
    <name>A0A914YXH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5196.t1">
        <property type="protein sequence ID" value="PSU_v2.g5196.t1"/>
        <property type="gene ID" value="PSU_v2.g5196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5196.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14105" checksum="8D91DF9D08F165F2" modified="2023-02-22" version="1">MIEILPEAEAYVGGVIPAPLNKEKYDPTLGSRADRLEKSVRLLTVMNLMQQGWELYADYWYKLFEVELMWVPAENFCRELGGHLVSIKDVAENHFVHKLRKSMFFFLFNPINEMPKILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXS8</accession>
    <name>A0A914YXS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4447.t1">
        <property type="protein sequence ID" value="PSU_v2.g4447.t1"/>
        <property type="gene ID" value="PSU_v2.g4447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4447.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13815" checksum="65DBAC16D165815A" modified="2023-02-22" version="1">MFQEDTFKKLADILPSLKELSDFSLYGLTEAFNFASITDFLLKNENLVINLGYNEGIPLSNGYIKILESFIAKIIEAPPKRIPDIYFPGFEKSVYYQDYLKLYNNQFYSHEYLTPSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYE6</accession>
    <name>A0A914YYE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4662.t1">
        <property type="protein sequence ID" value="PSU_v2.g4662.t1"/>
        <property type="gene ID" value="PSU_v2.g4662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045230">
        <property type="entry name" value="MBS1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213">
        <property type="entry name" value="GEO09665P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4662.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8310" checksum="FD17D4A8BABC3476" modified="2023-02-22" version="1">MARGHQKIQAQQKNAKKQEDAKKGGSDQKAAALKALKHQCTVCKAMMPDPKTYKQHFQSRHPKSDLPAELVEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZQ3</accession>
    <name>A0A914YZQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fatty acid desaturase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5579.t1">
        <property type="protein sequence ID" value="PSU_v2.g5579.t1"/>
        <property type="gene ID" value="PSU_v2.g5579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF88">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE FAT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="9">
        <location>
            <begin position="156"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5579.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="52384" checksum="C13CE8719AEFFFA2" modified="2023-02-22" version="1">MVLRETDHTDFHIKVEGKWMLITKEILHSHPGGVAISSYKDRDATTVFHTFHAGSSRAYKMLQSVWKEQKDLTFNIPVEKEEVPILGLDDINMGKFDKSDEESKQITENFDKLRHKVRKMGLLKGNTTFFIGKFFQCIGIISLAIFLQSQGIYIPSALLMGLAWQQLGWMIHEYCHHQHFENHYANDLASYIVGNLLQGFSSGGWKEQHNVHHAATNVVGRDGDLDLMPFWATVASDLKFAQHASSFLLQILPYQHIYWTFGLPFLRLSWLLQSIIFVSKMDRSEFEIHRTRARYEQITLFIHWILVGLQLYYLPDNNTRLTYFLVSQLVGGFLLAHVVTYNHYSTDKFPNKSRILENYPCLQLYTTRNMRPGPFIDWLWGGLNYQIEHHLFPTMPRNNLGKVMPLVKEFCIENNLPYMVDDYFTGWKKGIEQFQNVADVAYKLKMKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZT0</accession>
    <name>A0A914YZT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZT0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6000.t1">
        <property type="protein sequence ID" value="PSU_v2.g6000.t1"/>
        <property type="gene ID" value="PSU_v2.g6000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="332"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6000.t1"/>
        </source>
    </evidence>
    <sequence length="739" mass="82023" checksum="AB7D334865EA6CD2" modified="2023-02-22" version="1">MLRHCLKPSTSKTIFTTRFSTFLSAVERNPFVKKPVLVFGARYLSLKAPEVKLLNNIYEIVEHQILQARRIPLRQRGQSQKNGKKEDDLKATKRAIEESSDSTSGGSSQDGDEKPDMDKIIDKVKKVVVISLCIYGFIIMLSPRRSSLDPQSVTQTTWSDFVNKLLPTGQISKVIVYPEKDLAIIYLYAGAKSANGEPLHSVYRMGIPSVSRFEAEVRAAEAAINLTPEHWTQIQYRRLEGIGSIISIVILAAIIAGAYFLFKRVKVSFSMSDIMNQMTNTKINVIDPLAKDSKLKIKLKDVAGLHEAKVEVNEFVDYLRNPAKYSKLGAKLPKGALLTGPPGCGKTLLAKALAAECSVPFISMNGTEFVEMIGGLGASRIRTLFKEAKSRAPCIIYMDEIDAIGRKRSDGGDNQFGGGGSGEEEQTLNQLLVEMDGMDSSQAVILIASTNRPDILDKALMRPGRFDRHISVDLPTVLERQELFDMYLNKIKLDKKPESLVKRLSQLTPGFSGADIANVVNEAAIHAASYQHKIVNVNDLSFAMDRILAGPEKRSKTLVLEEREIVAYHESGHALVGWLLEHTDALLKVTIIPRTSAALGFAQYNPKDRKLFSKEELFDRMCMTLGGRAAENVYFNRITTGAQNDLEKVTKQAYAQVKNYGMSTVVGPITRAIVAKAYFNTENIIRDNREKLDILAKALLERETLSYEDVKKLIGPPPFGDKNVIEIADQILPEVSPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZW1</accession>
    <name>A0A914YZW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZW1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5638.t1">
        <property type="protein sequence ID" value="PSU_v2.g5638.t1"/>
        <property type="gene ID" value="PSU_v2.g5638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5638.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38454" checksum="CBCBD4A94952B70B" modified="2023-02-22" version="1">MSRGYSADYQNKASCNKHLNDDQFIGYRFQDDGYVTMMSEDWALGVFNWPNCKGFKPKPVDHYMRPFQLRIEGTKKYWLKGLKDKLYKKSCKESFHYQMDYLQNFIDTYPDKPKFSITWMSYLAHDDQNALYHTDTYFSKFFDDNVEKFNNSYLVVMGDHGNRFGPLRKTKLGEIEDNNPFLFLSVPSNLRDDSTLIETLKENAKNLVTHYDLYATLSEISNGAEIMVAQMNQDLRKFSETNDCVLLTLNKGATISVEELKEKGNVKVYQITYRTLPGNGNFWGFLTQVGENGTLNILSEKFPRLDAYAPQSKCASKAVFASYCYCKNLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0R6</accession>
    <name>A0A914Z0R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0R6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6324.t1">
        <property type="protein sequence ID" value="PSU_v2.g6324.t1"/>
        <property type="gene ID" value="PSU_v2.g6324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6324.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16747" checksum="57CC047EFB6C689D" modified="2023-02-22" version="1">MLLHKAWIFICDIVIGTIGLFIQFISAKKNSLGKPKEIKTIIFGDFEVFLKNKEWEALITTFRFNMPHDRRTILCCATYDDRACFNFYYIVRHYYWFVTLGEMNQVEGLVRQTFMADKVVNHDKMLIKLIIEKAKNGNILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0U8</accession>
    <name>A0A914Z0U8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0U8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5506.t1">
        <property type="protein sequence ID" value="PSU_v2.g5506.t1"/>
        <property type="gene ID" value="PSU_v2.g5506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="210"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5506.t1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47054" checksum="7CACEFC6D8163898" modified="2023-02-22" version="1">MSINYTRDASDQIPDVGDIRTVMKQIENHLHTLTDDRFADIHSKLDGVFEVVNKLNQLLTVTSTDVKEIKFLLNEVALKQQVSQETQTLPQEQLNQTSNSHGSNNIVSSAVDQPQALDFQKLKPSDASTPLASPFKHEESKQSQLKDSAKIEATLTSPEKNEAKFSQIEASAKNEAKELEAEPTSTKKAVPDRSHIQLDTTDEAFDGKMKELLFKRECKLFTFVRETKETFLRGHGIIYVVYHRNTNIFKVFMKRNNDQKICAVFKIRRNMQLSDKSGSKSTGLFKCMDFSEGEPKATCFFIKFQEQTSYEEFKKLFNDAVENDRLKNENNDAKSESSKESGNVNPMDIGQQISYNSSVADSNVTNVHDGSSTQHASPHLNSALPIPPPRGCNRDLVLQSNDASFIKFAKIPIYDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1T4</accession>
    <name>A0A914Z1T4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acid ceramidase</fullName>
            <ecNumber evidence="6">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the acid ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z1T4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6660.t1">
        <property type="protein sequence ID" value="PSU_v2.g6660.t1"/>
        <property type="gene ID" value="PSU_v2.g6660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.60.10:FF:000006">
        <property type="entry name" value="N-acylethanolamine-hydrolyzing acid amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016699">
        <property type="entry name" value="Acid_ceramidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017632">
        <property type="entry name" value="Acid_ceramidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037103028" description="Acid ceramidase" evidence="19">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="21">
        <location>
            <begin position="46"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="20">
        <location>
            <begin position="141"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017632-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6660.t1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44969" checksum="A0AFF28CFFC53AF6" modified="2023-02-22" version="1">MKTSIILGVFILGTVSAVYVPLPEKFADHCILDDGTNLYKPENQYQVPWFNVDLDADPYTRFQEISGIYKDNIKDLLQQIKNLITPFIPDALNIVDDVFGSMDQYLAAPYRDEIRGIADATGLPVGEIVMYNIFYEIFTVCTSIIAQDDQGHLHHARNLDFGLFLGWNATTHEWAISSHLRKMVVNINWIKDGKVLFVSNNFAGFIGIYNGMKKGAFSLTANDRFDAIGGYVGIIRWMIGLEPNSRWMTWLARETLEQKNSYAEAYEHLANTPMLSPTYFIVSGINPYEGAIISRTLNGTVEAQSVKMNPDSPYGWYLLQTNYDPNDVVLYIDDRRTPGNACMRKLGRSNVTFQGIYNVLSSRTNLNKLTTYTVLMDTIEGKFETHLQSCPGDCYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2E6</accession>
    <name>A0A914Z2E6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L28, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2E6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6531.t1">
        <property type="protein sequence ID" value="PSU_v2.g6531.t1"/>
        <property type="gene ID" value="PSU_v2.g6531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6531.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35699" checksum="441157F4DA936263" modified="2023-02-22" version="1">MSLVKNLKNLTSLRPRPVITWDKSERIRRNKEIWDNKESIVHRLPLHYQHRHWKNVLMDIQPVHYRPPENRYQWDTQKLVEVETEHYPILPIKPIESDHGLWGGEGVVKGYIESKPFTKKKVLPRLWLPKLWFPKLKTVILYSEVLDSHMEIIVTERALRLIDAAYGLDNYLLETPEVDINSKLGLQLKRQILISLAKQSYAADDPEQHSYIKEKYSRFVIPLEEAEWVGLDLNEACRKQQDLEDNTRPEPLKYKFERELMNQLESGDAPLEDDQFKPQKSLFGEKLLGSVMNPLARRMKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2L6</accession>
    <name>A0A914Z2L6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-sigma</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z2L6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4495.t1">
        <property type="protein sequence ID" value="PSU_v2.g4495.t1"/>
        <property type="gene ID" value="PSU_v2.g4495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000031">
        <property type="entry name" value="Glutathione S-Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4495.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23192" checksum="7CA4C60CDA3F3D1F" modified="2023-02-22" version="1">MVNYTLNYFPIRGLAEPARLLLHYAGQEFTDKRLTNEQWLAMKPLTPYGQLPILEVDGHTIAQSGAIYRFLGNKFGLCGKDEWESAEIDSIMFALLAFGNEVREFFAVSAGRQEGDKAALFENQFKPAAEKYLPAFHQALSKTGSGYFVKSGISYIDFVVAENVDKLNGLLPEFFAKHPSLLQHSKRVMSLPELQKYLSTRPQSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2T7</accession>
    <name>A0A914Z2T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2T7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6661.t1">
        <property type="protein sequence ID" value="PSU_v2.g6661.t1"/>
        <property type="gene ID" value="PSU_v2.g6661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6661.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21586" checksum="2CA7F29C86B00FC1" modified="2023-02-22" version="1">MDDWDADDIDVTAGLKSKLVDLGLENVVKKDDHPVPTTTATASSTSNERSAHLEALEAEKQSDLEAGMLLLGLAPDVKQKKFENLSSKKQFEDYGNEVGETYKTRSKDPNYMAFALPVVTHVCANMSKLQLEEIQQIVQGYINVFTQKEAEAKKVEQQKNEKKQKKNKKKQLEKDDMVVDEYADYEDQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2Z9</accession>
    <name>A0A914Z2Z9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2Z9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6434.t1">
        <property type="protein sequence ID" value="PSU_v2.g6434.t1"/>
        <property type="gene ID" value="PSU_v2.g6434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000005">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000051">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6434.t1"/>
        </source>
    </evidence>
    <sequence length="596" mass="68574" checksum="81707F5261968F5C" modified="2023-02-22" version="1">MVYQNRNRNRTNQFFNDLERLAGESSSARAQERSAVEMSNIRPIPNDERSPSTTSRSGSVFGDEVQRLLQHISDLYLNEEISDVTLIVENSRFPAHKIILASRSIYFKAMFFGFTELEHNVSEYLKEICKPENVCNIFCASQMYSMRSLAAHCLDFMDFHAEEVLKHPTFRNLSAEALEQLISRDSFCAFEITIFKAVREWMDANAEESRFFGEIVKNIRLSLIKLDDLLNIIRPSGLIPPDILLDAINDQTRCKTSDLGYRGFKFPNVNVACPEFGVNIIAGDNNKNYFSTDPLPSESERNAIKHPIKEKDPGIIVELARPHIINHIRFQLPEREQRSFSYFVEISMDKLDWVRVIDHTRYLCRNKQNLFFNKRVIKFIKICGTFTTSSVYTFQIMNLEVFFSPESFEVDSSTTLIIPKQNIATIQNNANVIEGVSRSRNALLNGDTRNYDWDNGYTCHQLQSGSIIVQLAQPYMINSIGLLLWDCDDRQYSYYIEVSTDQQTWNRVVEECEVSSWRRVTFELQPVTFIKVVGTANTANEVFHLVHLECPAPEDYPIGNHNSTNTRQFAGIHDGLPQMINNLEQGIERVAIEQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z368</accession>
    <name>A0A914Z368_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z368"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7136.t1">
        <property type="protein sequence ID" value="PSU_v2.g7136.t1"/>
        <property type="gene ID" value="PSU_v2.g7136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7136.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19544" checksum="88B75B9707401681" modified="2023-02-22" version="1">MTESGRGIIEGRQFTRSQDRLATIRHVAEGLAVDRLRCENREAAGHHGGNAAGHRKAAIVRFCGHQQGKRVIAVDRVLVKSARFVAGDRQVIAFWYKLICQFHGSDAFRAVAGSTEGDQQQRMGWVQVVHRIGDQIGGRYGAEVFTGMAGEPRRDDVTDKCRRSGSGQDDPQILFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3N0</accession>
    <name>A0A914Z3N0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD synthase</fullName>
            <ecNumber evidence="3">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z3N0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7303.t1">
        <property type="protein sequence ID" value="PSU_v2.g7303.t1"/>
        <property type="gene ID" value="PSU_v2.g7303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="14">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7303.t1"/>
        </source>
    </evidence>
    <sequence length="506" mass="56801" checksum="C25B92A81D77D719" modified="2023-02-22" version="1">MSSNSFEATVKRKTAGIIVIGDEILKGSTADTNSNFLCRRLHNRGVCVKKISVVADEVSEIAREIAEFSKAYDIVLSTGGIGPTHDDKSYEGIAAAFNDTLLLNSELKAVFDDVLAKYKQRPDAEESISKFCSIPSTATLIWGDDKTKGARKFPCVKTRNVIALPGVPSFCQQGFDQVENIIIPSDDTTPFFSKNLYLGKNEIHIQHSLGEVAKRYVEDGVTIGSYPVVGNSYFKTKLTVEAPTDNCGNAVFDELSEVFQSFVKNFDEVPWVNTVEKMKEFKKTLEPGFAKKLDDAENLIGEILKKFSYDEIALSFNGGKDCTLLLHLVRTKVDEIYGSETRIKAFHILCEDEFSELRHFLLDVCWKYNVQLRELGGSLKAGLTELKEVEPKVKAVLMGSRASDPKGKYMSSKCQWTDKDWPQFYRVCPLFDWSYSEVWKGLRGLCIPYCILYDRGYTSLGDRSKTKPNPALLMGDGGYKPAYCLEQDYLERCGRDEEEPLAQNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3T6</accession>
    <name>A0A914Z3T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3T6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7017.t1">
        <property type="protein sequence ID" value="PSU_v2.g7017.t1"/>
        <property type="gene ID" value="PSU_v2.g7017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7017.t1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47997" checksum="230D64541CB6584B" modified="2023-02-22" version="1">MQQTTASASRANGPPVMCSSPVCGKKFVPPAPIKPKIHATPRKSIAVLRRVNNQSFNAAKLPILDMSQFEDIPKKVPPVKNRHSVESNERRSKRPHPVTPQQQKIPSKLPVRAHPVTPKQQKVPTNVRQSNAFNLLQQYASPSTPRVPAKRASPPPVEDLSKENVSQTSPLPRENILQNTIITDFNILSIDDENPRRLITNNDIAPVEAENNENDHGNFSAFVIPSDDDYEDESHDIDEPQINGNDENEQQSKDYDDSIYSINTPGPSRICPIIASKPLIPLNFNDTLGDNSTVDRTLNATISSNKSPIHITAALKKNQKKCFILAKPHLIKPESPSIEHPNLRRSKRTRVRTLRRDLGEQPVYELDENRLPVLVGVTQVEIKNPRAQKYLTADTALQNQREKELKNGNKKRKQFAKIQREIEHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4C8</accession>
    <name>A0A914Z4C8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z4C8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6853.t1">
        <property type="protein sequence ID" value="PSU_v2.g6853.t1"/>
        <property type="gene ID" value="PSU_v2.g6853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10519">
        <property type="entry name" value="SET_EZH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000001">
        <property type="entry name" value="Putative histone-lysine N-methyltransferase EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="10">
        <location>
            <begin position="533"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="655"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6853.t1"/>
        </source>
    </evidence>
    <sequence length="798" mass="91393" checksum="A4243D3B233284D8" modified="2023-02-22" version="1">MVRRLSDSRLGPPPSTPTPTGTNPLHSCSPPKKRGRKNLSKNIKDSSPPLSPKRGRGRPKGSQNKKTKKQLFKQQLPQHHEEEENDEEEEVNGTVPEELEEEYDDEDEDEVMEEEENSSMEEEENSCDSIPKHFNNSSSSTVTTADVKEPLQYKPNKDLMKEIMKEYEKVKTKYDQKVLKDGYDFLHPYDNPSIKRIRVPSSQLKPRAPRMLFSDSVNYKDTNNHTVATLLVSYIQDHPRSPPMRYWTHTNVNIVGKDEHALSHIPYLGDNENDDAGFGEELLNTYDEGIHGEKVGVGKPINDWILFYVVDPILKRHQWKDLADIQRLMISLYDLFPNKNSAREMASAFTDLAQRFDPTNSTSRTKLFDALGEFCSHFSSKVIQSSNASLVCKRCYFVDCMFHPAEITYNDTHIERDDGRILDPDEACGPFCYRHSQIKENKSQKRNSRKRLSSALEVSVCEVLEPLEWTPHEESFIDLLKTGQIHSPCRISQFLSNLSRSSPKTCKQVFDYINGKGPFSPIVFDSNRIDGNSRKLQVAKSQHHRTFRSINGGKLNNQKPYQSCNHAGECSLENGCNCKKQKLMCTKYCGCSTKCSLRFPGCRCKPGNCRTKQCQCYYASWECDPDLCHDCNCQVNEETNLPICRNVCIQRCLQRKLYIGPSEVAGIGCFAEEAIPKGEFIGEYVGEIISQDEAERRGKIYDKFKCSYLFSLNEEQAVDATRIGNIVRFVNHSKHPNCRAKVVVVNGDHHIGLFALNNINPHDELFFDYSYNKSQLSEFVYKERKARHDHSRSYTPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4E7</accession>
    <name>A0A914Z4E7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4E7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5124.t1">
        <property type="protein sequence ID" value="PSU_v2.g5124.t1"/>
        <property type="gene ID" value="PSU_v2.g5124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="512"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5124.t1"/>
        </source>
    </evidence>
    <sequence length="607" mass="70184" checksum="0CE0150D7900CFA4" modified="2023-02-22" version="1">MNTKVNPCENFYEFACGSYNGIKQVPESEKKITLFTESRTRLKYEIRELIDDTSLRDSGNNNNNKSISDISKLVYIYYDSCMDDQAQDLLDLMPIFSLISSFGGWALLQNAKFEERDFSWEILETNLQIIGINGLFKFTIKQSMPITISNSGAANGAGYLIVSQPQLLLGDRKYYSNSLGKNEFLQNYRTYMMDLLELFGADSEASEPQLNNVLNFERKVANVSLFFCYGTLRLEKNEILLCVTITDNKFLVTITTPSSKLVKVNIQTLKSKFPKIIWKNIFNNEFFNLLPGFTESNLPLLVDMEYLQQLQVILSTTDSQTINDYLMWKLLSSFNAYLPQRYRIPHETITSVLKGQTIKPLWEECINEVIERLPIPMITIYNRLFNGGRYSKIERIEIEQIIKDLKEALSQIILNIDWMDEETRGAATEKLKHLKVNFNILKNFQSHTFENEILTQFNGLKLIGNTYFENTISIRKLQQKNEFKKLNSSNFLNNFSSLTFEAFIELIPFNLYQTNEIILPTSLLQFPFYVLNAPNSINYGSIGAIISRELTHNFDDYGANFDEKGARKNWWKKDTIKFFDSKKQCFIAQYNNKADSISGKKVGDVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4U1</accession>
    <name>A0A914Z4U1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z4U1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5270.t1">
        <property type="protein sequence ID" value="PSU_v2.g5270.t1"/>
        <property type="gene ID" value="PSU_v2.g5270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="10">
        <location>
            <begin position="520"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5270.t1"/>
        </source>
    </evidence>
    <sequence length="924" mass="106347" checksum="91509A6AAF90C884" modified="2023-02-22" version="1">MAQQVKAKAKVNDKSLSSRETILAFKKDVYTDLGPIVNAFRAYWYHTTSDTNNHKTRDLKIEKKMLAYLVSMIQNIPIPEANSLLIHQSAEIITVFISKDDGTLLNDEEQIKKFCDLVFEREGKVLCGLLYAENNHVPIFYSTEERQTMFLNIIRWNSGSYGMATKMNVFCRQGTLFCVICKTSYRNKGSHPNRCWQKCNSCFESGPEYPCQQELADGTWIKCDQCNLDFKSVRCHQNHLKTACKRQKRCKLCHATYQLGHGEMNHICGNKYCYQCHQHHPPNDRARGQHYCYIRKAKIHPDDFLRVLYVFYDIETIQKVIKAIPRKRVNSESEPYAHDKRPRIENTFEDGEAPSCSHHSEDSGVTHLTNFDQSEAPSCSHHSEDSGVTHLTNLEHACPELGEPSLAFMGAQHENADENGIVQHAVNSEAGKTLRDRIIAKHRGKSNSQHVANLMHSLIRCSDCIEDTDENRYCTYCHRQSTTFTSIPEHLLPSTSDENIVFDDDVTGAFMKYLLTLSQSSNYSSVYLYAHNASRFDSHLVLKAFTDRNYTTSQFIQKGNSIIEATISSGQGIEKALHFRDTYRIIPVALRAFQKTFDLGELLHKFDFPHFYNLEKFYDKILDTLPDKEYYGYSNMKKAEKAKFDLKYDAECKKMEENGSKYSLPLELKKYCIQDVNVLYKGFVEFRKIKNEVVREKVDEFDAKKLRGDRSKTFYDILLKGTTVAALTLYVYRLRFLNTDKVALIPETGYTDKTNQSKIATGYLEWIMKKNAHFIQHAHNIGEHKIGKISVDGYNIDTKEIIQVHGCLWHGCPSCYLDRTKVLLDGKTAGDFYASTVEKAKRLDKAIEDDPNYSKVVVVWECQIRKEMNKDKDMFDFINATEDVSNIDLRKTLSGGRTGPLRMQAKYTPGEHKISYYDICSLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z505</accession>
    <name>A0A914Z505_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z505"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5337.t2">
        <property type="protein sequence ID" value="PSU_v2.g5337.t2"/>
        <property type="gene ID" value="PSU_v2.g5337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5337.t2"/>
        </source>
    </evidence>
    <sequence length="148" mass="16794" checksum="F6B418E45A6F3721" modified="2023-02-22" version="1">METAEELQIANYGIGGHYDPHFDFARKEETKAFSDLGTGNRIATVLFYMTQPEMGGGTVFTELKTTVMPSKNDALFWYNLYRSGEGDMRTRHAACPVLLGVKWVSNKWIHEAGQEFRRPCGLKLSTYERYVGDLGGPEPRYNLNLSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5H5</accession>
    <name>A0A914Z5H5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5H5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7143.t1">
        <property type="protein sequence ID" value="PSU_v2.g7143.t1"/>
        <property type="gene ID" value="PSU_v2.g7143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7143.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30357" checksum="545B854E250E9C28" modified="2023-02-22" version="1">MSLKSFTDFINPIKKFSTIFGEIFGNEIPQKNTAAKFLNQKLNVIGIENGHGGRHLGCEHSIKALQASKILNSDRIPLYWREIVPETISGRQHSQLDGVIANSRNLCAAVRKACDEGIGIGEREELLVFGGDHSCAIGTWSGVASSIRPHGDLGLIWVDAHLDSHTPESSPTGNLHGQPVSHLLGYGNAHLKTVGDKFPKLKPENLVFVGIRSFEPPETEFLQKLGVKIFYDEEVTKRGINDVMLEAIDRVSHKTYGFGMSIDLDGFRIDDAPANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5K2</accession>
    <name>A0A914Z5K2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5K2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7624.t1">
        <property type="protein sequence ID" value="PSU_v2.g7624.t1"/>
        <property type="gene ID" value="PSU_v2.g7624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7624.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33272" checksum="C9AE3C00D4ADE0CD" modified="2023-02-22" version="1">MSYCTLFPSKKNHFFSETEDGDFYFVNRKTGQSSWEHPMDEHFRKMADHWRSNVTEPLPIPIPSSMNNNNNNKIKPKRIIKIPAPLNIVKPSSSPTSPECPELLSSGSEKEKVYSSDSGTFDTDEENEMRDTVILEHDDDNNDNDKKDYFYLSPRRDSIEEKEEEFNDGSKRVTFSKNLVKVYEFDATNMHWIRSNLFRKDGSDPQPIREYLDGENGITDKITAGQRPSTPRMIPTERYERLRQVQKRADAVINRNWREFCNAVTESYARAYQLASTVPSRPSMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5Y7</accession>
    <name>A0A914Z5Y7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5Y7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7324.t1">
        <property type="protein sequence ID" value="PSU_v2.g7324.t1"/>
        <property type="gene ID" value="PSU_v2.g7324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7324.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="20910" checksum="4E4818FCBDEA695F" modified="2023-02-22" version="1">MAFFQSVSSCAGGIGGGGGVVTNPSVSMKFHPPTAWTYPETTALTDLAYFPGQPLTMSEAQLRANGDIESAVLAGLNALQVSTLGVKITPQYSPPLVSDCKKLSTAGATMSQFGFQEGGAITKLITPPAAGIDFTACSERNFAGIPPTTVFTMVDFPQQASAKIDGITLSEYQATLLAAKVSQYLMLNSKVDFIEEAIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7N7</accession>
    <name>A0A914Z7N7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7N7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g626.t1">
        <property type="protein sequence ID" value="PSU_v2.g626.t1"/>
        <property type="gene ID" value="PSU_v2.g626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g626.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32714" checksum="E90033AC197523F0" modified="2023-02-22" version="1">MEEWIQKHEGKEKQKFLQLLKKYQSNPGLEDIDELNVKQESDDGPNVSRKRKHCETESIVDNADKDIVLSDVTQPNMNDGQNFDTDVSVEIPSKKQQLMFSTEQCRKVIDKSCFKIVNYKQKNGIYRKLLVFAKSEPSYCYEYNWNGRKKYFNHRCNKHPNGHKAILALDEEGNEYVKLEDKPQKCAPILYDPKRYNEVKITKKSNYEILENCKTKSKRILIIFDSNDKTQCYEYYLTSQNKFECCGCAVKKKHLVAEIYYENTENEYIRLQNAQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7Q2</accession>
    <name>A0A914Z7Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7Q2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7900.t1">
        <property type="protein sequence ID" value="PSU_v2.g7900.t1"/>
        <property type="gene ID" value="PSU_v2.g7900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901:SF2">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="1">
        <location>
            <begin position="81"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="1">
        <location>
            <begin position="260"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7900.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38891" checksum="08F05AE8B381FAA6" modified="2023-02-22" version="1">MTDGLQTVAPKSTIKQLIAETRPTTTPFAPTTKRTSAAATTFVAANIDDEIRAEASGPPSEVIGDLCFGEWRWPRDCRSNCDYRLSWNFAEASDEIEFSLETKISSNWWSGIGFSKTGTMKDADLIVVKSFGGVLSLHDMSSTSYDTPKEDAIKNVYTPTVIGTHVNGILRAQFTRKRNTGDINNDAIFTDNDCFHFLFPVSGGRLNAQGDILKHSNTPHVTSQKVCIKSCEINASGEQEAEPTCNNEFKFPDNCKGNECDYIARWNYNETRDEVRFEVKSKGVGRWTGLGISKDGAMANSDIYTGWVYNGKAYVVDRFAYGRQLPAIDPADRQDLYDIGGKIEDDYQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z869</accession>
    <name>A0A914Z869_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z869"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8874.t1">
        <property type="protein sequence ID" value="PSU_v2.g8874.t1"/>
        <property type="gene ID" value="PSU_v2.g8874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF55">
        <property type="entry name" value="POTASSIUM_CHLORIDE COTRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="47"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8874.t1"/>
        </source>
    </evidence>
    <sequence length="508" mass="56551" checksum="905B55C34A1871B2" modified="2023-02-22" version="1">MYCKNAFPGFNLETLKRNMHPYYLEKDEAKPGVMGMKYEVTQDVSVTFWLLLAIYFPAVTGIMTGTNMSGDLKDPQKSIPAGTIAATITTSLIYFALAILFGASIEGAVLRDKSGKSIASSLVVASLSWPTPWVVIVGSFLSTFGAALQCLCSAPRLLQSIAKDDVIPMLAPFARVTKSNEPFLGLLFTAFIAELAILLGAVDDIAAVLDFFFLMCYAFVNLICALHSLLGAPNWRPRFKYYHWSLSVAGAFLCFFIMFASEWHYALIACGLTMAIYKYVEWKGAKKEWGDGIRGLALTTAQYSLLKVEDKDPHPKNWRPQLLILVDGKYSKEMIDLRSVNLLNLAGQMKAGRGLAITVGFVKSDNLHGLKKRADDIKHRIQQDMLQARLRGFGKCLFFEQHQIYGAVSALYQSVGIGGLRPNTVILNFPRQGENENSVEQLIFAEQLIRGVQYENCMIVCKGITDFPKATARLSGTMDIWWIVHDGGILMLIAFLLQQHKVMKMKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9A2</accession>
    <name>A0A914Z9A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9A2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6826.t1">
        <property type="protein sequence ID" value="PSU_v2.g6826.t1"/>
        <property type="gene ID" value="PSU_v2.g6826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001985">
        <property type="entry name" value="SEM-4 long form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6826.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7389" checksum="EC622E6797EA5AAB" modified="2023-02-22" version="1">MGFGSGGSSGSGSGESNPLDAIQRMWKDAETTPPARHPVALSKHQCGVCFKHFSSSSALQIHMRTHTGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAD4</accession>
    <name>A0A914ZAD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAD4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g721.t1">
        <property type="protein sequence ID" value="PSU_v2.g721.t1"/>
        <property type="gene ID" value="PSU_v2.g721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g721.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23685" checksum="80FF311E9246A22D" modified="2023-02-22" version="1">MIEGGGLLAQGEPAKVITPTRWPRLMAYAPRGELLARHLANHYRRAARACAVTFGEPMNILRHLLLSLTLLCLGVQAQPIEVTDAMGRTARHFPVLALVHPEPANLIAGWSDEFKTSFSNEYETYLKRYPQLANIPYCGSPYGRYLLDRTGPGPASGSGRADGRLCGPDSRSGHTRLGPDPAPDCRQSARHCDRLLCEPAGEHRTQPARIGLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAG1</accession>
    <name>A0A914ZAG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAG1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8904.t1">
        <property type="protein sequence ID" value="PSU_v2.g8904.t1"/>
        <property type="gene ID" value="PSU_v2.g8904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222:SF76">
        <property type="entry name" value="MYCOBACTIN IMPORT ATP-BINDING_PERMEASE PROTEIN IRTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8904.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19468" checksum="830D0FB40208EC9E" modified="2023-02-22" version="1">MSEKKTSEFEVAWDSQSEPGEEKAKKVSLAKLWRYATGKSLLLVILGASIAVVTGAGMPLMSIIVGSLSESFVKMTKLRESPNSLVCPHDPSCNTTFSDIYTTEDFHNDIINQCTSFAILGAAIYIAAFIQVSCFLVSGEQMIHKMRLAFFRGILHQDISWFDKNNSGTLTTKLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAT4</accession>
    <name>A0A914ZAT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAT4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g903.t1">
        <property type="protein sequence ID" value="PSU_v2.g903.t1"/>
        <property type="gene ID" value="PSU_v2.g903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g903.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22485" checksum="FA7CB9F2D99DF4D0" modified="2023-02-22" version="1">MNYLTTIRTATQLDNDGYLFYYKFGLFQNKWNQIFYKLHSHCIFDWFYDEKFKKPSGSVNLKNVAPYICIGPQTRLIPFKKPKLEKGWNQNQLIGIVKDRTVHYFYFKSIDNLKQWLSKVINKFPSDAKDTYTSSPYFSKNGQEIRVDHNITTIYNSLDNFLGLYGFGWHFWLKNNKDAPVYGNFNVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAY8</accession>
    <name>A0A914ZAY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8926.t1">
        <property type="protein sequence ID" value="PSU_v2.g8926.t1"/>
        <property type="gene ID" value="PSU_v2.g8926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8926.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15171" checksum="320524E634FB015D" modified="2023-02-22" version="1">MIHKPCGIHNPKAPCMVDGKCKRKFPQKFCEETVMDDNGFTRPKRPDNGRTFKMKVNGKEVDVDNRWVYFMSLNTCLKVMIKAFVEMNEFIDNEMVQALNYDEIKSYEDYRYISATEAHWHLSDFGCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB09</accession>
    <name>A0A914ZB09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase FkbM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB09"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7438.t1">
        <property type="protein sequence ID" value="PSU_v2.g7438.t1"/>
        <property type="gene ID" value="PSU_v2.g7438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989:SF3">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989">
        <property type="entry name" value="UNCHARACTERIZED DUF13 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="69"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7438.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26699" checksum="09DB62B5BDFBB483" modified="2023-02-22" version="1">MNSRLLNYHLYCFASIFGILLYIIYSHLKTSNYNDILFSYRQCLQKIYDKNHEPNSYILEYRQCVVENIDTNFEKFRMGRLNEDKVFLPMKSTFIQQKCIWLTVGIGGDDKVEELFKKKYPACQIFGIEAESSQYANFDKYGTIIPYGVGVKNETTELILRTKTNYKQTKVEVLALPYLLDKFVQARQIHYMTIDIEGFEFGILEALLPQNKLYKENIVFCQVIAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBC2</accession>
    <name>A0A914ZBC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g922.t1">
        <property type="protein sequence ID" value="PSU_v2.g922.t1"/>
        <property type="gene ID" value="PSU_v2.g922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g922.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8823" checksum="5B888B3265C95BF2" modified="2023-02-22" version="1">MYPNPYYYPPQQNDPTKPPPQYYPQPSGYPPQAPPQPPARPDPTPTSSQPFYNWLTDRNPTNLHKTEDILFRPQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBC6</accession>
    <name>A0A914ZBC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBC6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9610.t1">
        <property type="protein sequence ID" value="PSU_v2.g9610.t1"/>
        <property type="gene ID" value="PSU_v2.g9610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9610.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11274" checksum="A2B24BBACBDD378C" modified="2023-02-22" version="1">MSNNTSSPNQIASTSKAEENVGKVEIILIPSTPSTPLIKRCRPMTDEMFLRAPSKERIARRSENFISSSTSSICHPQTPRRQSDFQYRSKKSLFVDGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC10</accession>
    <name>A0A914ZC10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC10"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7783.t1">
        <property type="protein sequence ID" value="PSU_v2.g7783.t1"/>
        <property type="gene ID" value="PSU_v2.g7783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7783.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20971" checksum="FADF0E18CC27A98D" modified="2023-02-22" version="1">MHLPGQTAIFTGRSAFNPFTQAVSAVYTEDLVDSWGAGYAVNGVNNYNLKVRKNFDEYADAPLGRNDGGRQPFLSGLSVGAEYDLSKIREVAGHLDLPLIGVNELFDLDGRFMVKGFGNGIANGFLDFPLTLSDPHERFPAVFKYLNYMADRHMHYGHVVPNVNLFLVDKDKIMERLSRNRLNPTMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCG7</accession>
    <name>A0A914ZCG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCG7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7945.t1">
        <property type="protein sequence ID" value="PSU_v2.g7945.t1"/>
        <property type="gene ID" value="PSU_v2.g7945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7945.t1"/>
        </source>
    </evidence>
    <sequence length="608" mass="67491" checksum="FDED118CAED2EDD1" modified="2023-02-22" version="1">MRELKNDIRKLQDTSLIAAGLSQKFNKLEKNLEEVAAFQAEMVQKMEMKDGPQIEAEKKVGDFLKTPDKVDPLSRFTDPTFLAQQRKEVVDQLKMRGPFDELLNRIRDISIKGKSVEATTEAGFDEGNQKEPSSQQDEVEMAQGGGTVAPLKPPEGASNSSDINILETSEVHPGGWEVGITGAEVNHLEFEMESYDGDPLVPLNAYFSRLKCYLMQQPFPLTPDQQLAHLVGRLKGRALFAYQALDAATQQNFAAFEAALKLKFPNTECIRAAEGELQQVQQRPLESVHDFSIRVASLIHTILEGKAEDEIERNLRRETMNRLQDDIREYVQDQNPDTYEKVLLLARRREAQLQRRQLSSIQRPAYETFVLERVRKCFNCGQPGHFARECTGNRDNRRPNFQKFNGNGGTWKNDRGFTAYRGQSEGSGTQFAGNRNGYNNGNGGHRADYGQGSGPRYATGQGSGVRWMHRPTGGNDTPLGPPSNTGNGYSVKFASANMVEAPQADINMLEVAPADKKKKRPRKIATATAPADGAAGNRPTQATSLKVGHKRNQGQVKQSARAGPRDKTRSGVLPARPKAHPDATFQINTILQQDFENNGGSKRKLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGF3</accession>
    <name>A0A914ZGF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGF3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9369.t1">
        <property type="protein sequence ID" value="PSU_v2.g9369.t1"/>
        <property type="gene ID" value="PSU_v2.g9369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037643414" evidence="2">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9369.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11366" checksum="AA245DE081DD1FC4" modified="2023-02-22" version="1">MKFIFVISLIFLFAAVFSTVNANRAKRSVTTFNSFGSTATNNGHVVTHANNHLTTANRGHVGTVGNIHNSAVNPHSASHNSISNVHNAGPVGAHNSHAAVHSHHVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGL7</accession>
    <name>A0A914ZGL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGL7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g943.t1">
        <property type="protein sequence ID" value="PSU_v2.g943.t1"/>
        <property type="gene ID" value="PSU_v2.g943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036857181" evidence="2">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g943.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28649" checksum="3CC4D7057E2CEF1F" modified="2023-02-22" version="1">MKNYQILPFLIFLFSSISIIVNGHICAEYKQEISSNNRIDASKNPSFVVYPSECKGCVATIEKGNFQTFCDMGSDLCETTKALNCNHKSCCCRGMFCYDQLRSHFASAPSPSSTECIVQRKSQTTNEPESESDNGETSYSRNTCSICVAEFHGNAIESRCVDSENLHSECLFATELIGEHLACTKDRKKCCCRSNNCQKQFEKLFFENGENLGQSFISEPYVSPTLELKDSAAPNLHNFSFAEALILLFFTNLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRF4</accession>
    <name>A0A914XRF4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XRF4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10573.t1">
        <property type="protein sequence ID" value="PSU_v2.g10573.t1"/>
        <property type="gene ID" value="PSU_v2.g10573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10573.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20123" checksum="2C069F52EF64D7BA" modified="2023-02-22" version="1">MIILNTVMLLIELFCGFYTKSVTIIADSFHMISDILALIIALISLKISQRKANSKHTFGWVRAEVLGALVNGVFLLALCLSIFLESLERIYDTQEIEKPWIVLTVGIAGLIVNCIGLFLFHGHSKSIESSDERNCDDDNAVVCHSYQSRVFSVVHDQTSKDETENEKSDDLKTSPKTQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU22</accession>
    <name>A0A914XU22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1047.t1">
        <property type="protein sequence ID" value="PSU_v2.g1047.t1"/>
        <property type="gene ID" value="PSU_v2.g1047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548134" evidence="1">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1047.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30414" checksum="66A51538AD5C8298" modified="2023-02-22" version="1">MNCSFQIILVSCISAIVLGQSTTCSNNNLLMTPTLRQKVLNVLNLARNKLESGQLLLNNGEYAVQAASLPDLTWSCELEEEMFERMEESCDSPLNADLQSLGLTWTFNRFDDSDAETLVDAMLENQSVLTGFYHVQLSRHNLYLEPISTFGTQIIALSDKAQYVACAIQNCNISAVSSGWALPGEIMNNIYCKVSLTEQLEFGDEIYQISPSVVNYIPPSQDVVCPSSGMVIEQREAVLEKINAARSQISQSNYPLPNGNNALPPAQPLSPLVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUB9</accession>
    <name>A0A914XUB9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914XUB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1155.t1">
        <property type="protein sequence ID" value="PSU_v2.g1155.t1"/>
        <property type="gene ID" value="PSU_v2.g1155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1155.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10607" checksum="F1607197ADC03908" modified="2023-02-22" version="1">MSKREAEGFYAVHAARPFFGELVETMTSGPTIVQVLEGENAILKNREVMGATNPADAAEGTIRKTFALSIGENSVHGSDAPETAAQEITYWFSSTEIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUM8</accession>
    <name>A0A914XUM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11651.t1">
        <property type="protein sequence ID" value="PSU_v2.g11651.t1"/>
        <property type="gene ID" value="PSU_v2.g11651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006874">
        <property type="entry name" value="DUF621"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718:SF25">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04789">
        <property type="entry name" value="DUF621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11651.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28693" checksum="FD955378D8C5AC43" modified="2023-02-22" version="1">MAESGNLTKWQECFAANRSYPIAANRLFVAIPLLIGNICAVSANVTLLAILIRSWKILGSNKFNLLILHLAAAHCFYESINFISSLPSLFASGPIYSSDFIQTATAFFNTPPATTVLWMNTLIAMERFAYFIIPKLHVFMNRRYIRQALPLSLWALAHAMSVFSEIHGCKKRFNQWNMVYTFDCSHCNLTDSLTILDLMTGMSQTLPIILVVCYVITFMQIFNIKFIKSSNDEMAVRNTNAEIKVVSGFCIIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUU4</accession>
    <name>A0A914XUU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUU4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10306.t1">
        <property type="protein sequence ID" value="PSU_v2.g10306.t1"/>
        <property type="gene ID" value="PSU_v2.g10306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10306.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17509" checksum="65B36AE80902F54F" modified="2023-02-22" version="1">MKVRKEGAGLFIRRMESLTSCAETCRSNFDSVENQIFDCHGFSIIGIDLEKRCEFYDESADEIPLHTLTSMESKSTYFEKQCMAIPSHCTNGAFSFELQKDRILFVSPIESIVVDDRKRTCQVLDKTCRAVAGGLVQISGVDHYENTCVQDDTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV66</accession>
    <name>A0A914XV66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XV66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11828.t1">
        <property type="protein sequence ID" value="PSU_v2.g11828.t1"/>
        <property type="gene ID" value="PSU_v2.g11828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11828.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25439" checksum="A59EE09C5854A175" modified="2023-02-22" version="1">MYFIATNQGHKYQNRDLESFRVSWNKSKEAVETFLVKIENVTSIKSDDILMTYELEQIGTMLKKENNNELEALVQQILTTISQISMTSKFNLAKKPSVEPMNDSQKPGLFKALEICRKHVVDVNLKQLFQKLVEAYGQESVVKNAEKIGRQIDIILMDVNGELYDMITEFIDGNESTKTDLTKSIDIFADKFADEMRNKKSFHEHFAKNLLNFKWLKTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVQ8</accession>
    <name>A0A914XVQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11316.t1">
        <property type="protein sequence ID" value="PSU_v2.g11316.t1"/>
        <property type="gene ID" value="PSU_v2.g11316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11316.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16011" checksum="41898FC429479FBC" modified="2023-02-22" version="1">MVESAPISLHHICIKPANPNLLAEMKKNYPETCHDVMEGEVDLFCSPVSKMFASINGLALEYEQKLTAVGCDFDEYCRILSMSDGARRFIQDKLTAATLVYFTFGAEYHQYLTDDVAVLSKLSIPLLMVIAFQPRFDTSYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW61</accession>
    <name>A0A914XW61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10021.t1">
        <property type="protein sequence ID" value="PSU_v2.g10021.t1"/>
        <property type="gene ID" value="PSU_v2.g10021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10021.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26802" checksum="D728DFF99591A7E6" modified="2023-02-22" version="1">MPKNLALQRINTKALQSSGQILYKKVITTKLATTQELQIQAEPEYVSGYNESVNFVYFEVLQTAMENITATLKAYIEERVTDITISFEAHVKSRLNNATETFKRQMEDHIDNATSNLQIYIENLDQQIYTLSNQTNNRIATTKTECENTKKKLSSLVECSNARIPVVYGKGGYGSNEAVNRLISAIGDGPKKLFDKSYVRLVAAAGDPRIFTIKCWSNDVTLDTVVLTDGSEMAFEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW99</accession>
    <name>A0A914XW99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10808.t1">
        <property type="protein sequence ID" value="PSU_v2.g10808.t1"/>
        <property type="gene ID" value="PSU_v2.g10808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10808.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25057" checksum="C13BD2DF41070051" modified="2023-02-22" version="1">MNYIIENIVYNNVYKKNIQDKGNFGKIIPVCKESKKNEKFALKMSKEGELGQIRNEIKILKLFKGKIGSENIINLWGCDETKGYLLLDLAEKDLGDYLKEKEIGEKKVQVIMIQIINGLKFIHHLDVVHGDLKATNILYFGKSKFKICDFGRSFLLKEKKECERDLQNIGYLLKNDFYKSKMDKSPAEFSELFKKLVPNPTVTAEEVYDLLVNMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX58</accession>
    <name>A0A914XX58_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XX58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11117.t1">
        <property type="protein sequence ID" value="PSU_v2.g11117.t1"/>
        <property type="gene ID" value="PSU_v2.g11117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.380:FF:000001">
        <property type="entry name" value="Copper homeostasis protein CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008603">
        <property type="entry name" value="PRK11572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11117.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="25513" checksum="9079079421E9800F" modified="2023-02-22" version="1">MECALTAQQNGADRVELCAAPKEGGLTPSLGVLKSVRQRVTIPVHPIIRPRGGDFCYSDGEFAAILEDVRTVRELGFPGLVTGVLDVDGNVDMPRMEKIMAAAGPLAVTFHRAFDMCANPLNTLNNLAELGIARVLTSGQKSDALQGLSKIMELIAHRDAPIIMAGAGVRAENLHHFLDAGVLEVHSSAGAWQASPMRYRNQGLSMSSDAHADEYSRYVVDGAAVAEMKGIIERHQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX60</accession>
    <name>A0A914XX60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11553.t1">
        <property type="protein sequence ID" value="PSU_v2.g11553.t1"/>
        <property type="gene ID" value="PSU_v2.g11553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11553.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="17943" checksum="3795F17356ECECC0" modified="2023-02-22" version="1">MSNEYLASGPIRLKELLEAGVRTGLGADGAAGHQVDLFQIMRQAVYVQRLARLDPQASNAQDAFWLATRGGAEMLGIDAGQLSEGKLADMALVNLDQAHLSPCFDVVASLVYCASGRDVTTTIVNGQVIYENGESQCVSKQEVVAKAREHCTALITRLGVVKPAGLMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZC2</accession>
    <name>A0A914XZC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13301.t1">
        <property type="protein sequence ID" value="PSU_v2.g13301.t1"/>
        <property type="gene ID" value="PSU_v2.g13301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="54"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13301.t1"/>
        </source>
    </evidence>
    <sequence length="1139" mass="126184" checksum="1B0F7434DCDEB3A4" modified="2023-02-22" version="1">MSSLSIATTTDADGSLPSTSSTSRSITSSTTTRSYTSPSRRRSPTTSLRSAQIGIRNGSISQKSNLEEDIGTNKSGIITGLMAFSKSSKKTYYAILSDRCFELHDNQKTYKKKKSARHIFDLATCFNINRHDDAKLKNSISIMTPDDTFIFRAADEEKQRDGNDRATMDWYDAMMIALVNARALHLGRPVLPAEFFEYCWDVTLVSKPKIRKPVPNPENFENICVLRPELKTRHRLGFYAHTIILCKMGIQPAMSGLPKSGIPPFRTEHFIEIQRQYVASFGFQEKYFIMRVGRAASTGMCEIWAQCESEEVAASIHTRLNEIIEREGKKRKSQSSSSHYHHPPSSSSSSTTTVTGASKDFPSSSRSEPSQSPKIEHLTPEPTIYQAAPSLPPKTTMSLTTSLQRPRLTDITYNIPEDETLSTHSTGYYRPLGAKSIDQAILRDITRHEEKSIEDQPRSLTVGSQSPSSNTWLNMLRRGNRGDTRTSISTGTTPTSSLKHTDRFSPTITVSQQQQPRKTPKQSSFYPVVEWAKQRASLISGSSQPDDETEDSGGTLKVVDYEDTIPERPSVYMNGCLPHEKLIELALEGKLRYDELGSRGSTSSYLDEEANEEKKDKLNDETRKRQITNDSGKGEDSDSDRYNRFTPEEQEDSSSLTADDAYSDDLSDRNHENNYEACSTSSMGGVSSHTSGHHEKESNSSGSVSHLLVPSTTEQQHLEDIQSYISDSSDSCYSSLNANAYAQNPPRAFSFSSNLVQSERNTYEMMHPSKFASRIDEHKPFSGTEESLPLSNEGLQLGEEAATSATMPKTVVRISGNVSLGPKEDLRKRAFSLGSRSWILNPLRKLSGNHARASSSKASSIADESENECNESVASHRSHPESTVATAAAAKTAVQPPKLLSPNGRSDSIDSSVSHPGRVTRYTKNTSKKANDLMEVNFSPPNTIIQQYNAIGSAAKNGSNSSVDSTQRSRAPSFITPRPSTEATNSSNVIEKIVECGESTQGPTEVQMAEVQCFIKKDDELMLYALMKEKDTTSLYSTKTESSMPYFETIEENVSSPSSPRSSSRHSRKSLEPIRKESVARLQPPVEHLNYVVIGPEKIPERKISVPSLRIRKDQQPRQSLSQSRSDNLKASESSSKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y036</accession>
    <name>A0A914Y036_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y036"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12581.t1">
        <property type="protein sequence ID" value="PSU_v2.g12581.t1"/>
        <property type="gene ID" value="PSU_v2.g12581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028054">
        <property type="entry name" value="DUF4481"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31193:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31193">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN C9ORF91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12581.t1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40815" checksum="254766B7B0BA188B" modified="2023-02-22" version="1">MGSQKEDWISFDSELAKVKKDESDGGGGDPLNDMNDIPLDEEKPSPPMPAGKTSADNIIAEIGVTSHEEESSKSSRKGSTEFPKNGRVSIEVDETKVMKNGKNIANISPINERMAWIVPPIYDSTKQHPAVAAAGLPQDTYSLVIRHITEDIRFKSYIIGFSRVLPFWIIFSIFILLFLLLTSPDGGFWVMVMTFCWMLMLFIGIFFCVIIRKHLRIGLAELVGEANKHLLHYNLIAGVQDRGQLSCHKVVIIFMYYESKECIVDIEKMLRIANSTAKPKPILMTHDEMASQCDQLLRGHIQPYIKSFVKRRLLFPTRPAEGVSDFRPKHCQKNHCLCQFVEEEYFNAIKRTWYDRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y069</accession>
    <name>A0A914Y069_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoinositide-dependent protein kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y069"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11269.t1">
        <property type="protein sequence ID" value="PSU_v2.g11269.t1"/>
        <property type="gene ID" value="PSU_v2.g11269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000324">
        <property type="entry name" value="Phosphoinositide-dependent kinase 1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="78"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11269.t1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63998" checksum="89792D4010D4B687" modified="2023-02-22" version="1">MSGSPIFEDGDSSISNGSTPLPLSTSDSEEQQSQPTPTLPSPPSDPSEVLNNKTHKDIVSEMRKEIIKTAPNRQVSDYHFLKVLGEGSFSTVYLAHEIQTNKNFAVKVMNKESIRREKKFINVLRERDVMASLTYAFGGHPFIVDLHCAFQDRTRLFFVIKAAPNGELYDLLKYMGKFDKDLALFYCTEIVEALSFIHKCRVIHRDLKPENILIGEDWHILISDFGSAKIVGDKEQEALETEEASQLRAQGQSRGSFVGTAQYISPEVLQSQCAGYEADYWAVGAILFQMLTGYAPFRASNEYHIMRRVMNLEYDFPEGFPQSAKDLIQKFLVIDPSKRLGSLDMGGFDQVKNHPYFEGIVWDEVKSRYAPSLLPKLPSNWEKNHTFPEVTSNVKPGLNEDALTRLMGFGADAPSSPPTPPPPVNVLSPDQIKELKLTKQKSENVYHKFVNENLIIKYGFVDKKKGLFARRRMFLLTEGPHLYYVDPVNMELRGEVPFTKELRTEAKNFRSFFVHTPNRSYILFDPERNAKAWCDAIDEVRDRYFKNNDIKKESGESSSKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0R2</accession>
    <name>A0A914Y0R2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl hydrolase family 31 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0R2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12376.t1">
        <property type="protein sequence ID" value="PSU_v2.g12376.t1"/>
        <property type="gene ID" value="PSU_v2.g12376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12376.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19034" checksum="947CD4E648D2542D" modified="2023-02-22" version="1">MMIIPVVQEGTTTVQAYLPKAASWYSLFESYYGTIVGSGNTFLLAGWDSMIPIFLRGGSILPRQAPALTTVLARKNRFELVVGLISDESGNKVATGELYWDDGDSIYPEDLSKHNFYHFNFNFKATTKSASLIITQTKAATSLHLPYLENIEIFGYPFTPDFTTATADQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2F8</accession>
    <name>A0A914Y2F8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sarcosine oxidasee (formaldehyde-forming)</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2F8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12967.t1">
        <property type="protein sequence ID" value="PSU_v2.g12967.t1"/>
        <property type="gene ID" value="PSU_v2.g12967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF7">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12967.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16374" checksum="833DAFF23BD6374C" modified="2023-02-22" version="1">MIMSDNCEEMYMIPEVDYSGEIKIGVHCGIPINPDDKNRVIPPQWTIDIPSEHLKKHFKDVEWEKPMRRISCLYTLTNDHNYIIDYHPKNSNIIIGGGFSGSGFKFGAVVGLILAKMTMEEESGLDLSIFKLDREIKNDKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2K3</accession>
    <name>A0A914Y2K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2K3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13470.t1">
        <property type="protein sequence ID" value="PSU_v2.g13470.t1"/>
        <property type="gene ID" value="PSU_v2.g13470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13470.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47906" checksum="2E9DAC4AB5D839E0" modified="2023-02-22" version="1">MEEFKITICLNSRSKGINKIQKELTKILEREVSNVEGLRKTISIFDGNNQEDAAHAIIKIIEALDKPSTNLVQFCYDTVETCLCGEKLKRHANNCFSLHLTVGKEDCQMTTFDSMINKWLKFNSYHCSKCGVKKVTEHLIKFGEVQQYLIVELNTLINGPNGMVQCSVPFNNFNIRGHLIFGTLWELQAAIQYTGSGKEGHYITWRKINHKWIVISDNQWRKEDCLLSDMNQYRVLVFKKLIVRIIEENYVNQEEINQGMSYCKIEEINVPQPFYSQNYANEILEQNNQQQQLHQTYFQPGINSDAIINCQQNIIQSQEYFIPPESPQHYLNSNNFTSNLNANNNQPYANFQEMIYETPQPIPPPTYSTFNKFQSLQPLQSIEEYNYCPPTSMPSIMPFEAGNAEDDDWINNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2M4</accession>
    <name>A0A914Y2M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2M4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13027.t1">
        <property type="protein sequence ID" value="PSU_v2.g13027.t1"/>
        <property type="gene ID" value="PSU_v2.g13027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="3">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13027.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33068" checksum="6F644C2402287877" modified="2023-02-22" version="1">MKGRPISDCHNFIRVVARRRNGHLLVCGTHAFSPQCREYEFLRSENRYKSQRDFNGRAITPYDPRANFTYVYSPESNEIFVATVSDFNGNDPLIYKKKIPTGDGIRTQKDDLRVLDHPDFISSFSYKDFYYVWFRERASESSEEQIFSRVGRVCRNDNGGPSTTQDRWSSFLKARLNCSIAADVPFYFNELQSISEPIPQSDGDAIVYGVFSTSRSAVLMNAVCAFKMSAIDRVFNHGNFKTQRSVSSYSNQKSQNFRGNERPGKCPKDSRSLGDISFILKNPLMPLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2P9</accession>
    <name>A0A914Y2P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2P9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13725.t1">
        <property type="protein sequence ID" value="PSU_v2.g13725.t1"/>
        <property type="gene ID" value="PSU_v2.g13725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13725.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24982" checksum="D4F3180FDBBBF988" modified="2023-02-22" version="1">MNRGQLHPYQLEGINWLRHCWSQKTDAILADEMGLGKTIQSMTFLYSLMKEGHSKGPFLIAAPLSTLINWEREAEFWSPDFYVVTYIGDKDSRSVIREHEFSFAEGAVRSGPKAQRMKSDAGVKFHVLLTSYELINMDKAILSSIPWEALVVDEAHRLKNNQSLFFRTLSEFKINYRLLLTGTPLQNNLEELFHLLNFLSPDRFKVTVAYDDQRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y353</accession>
    <name>A0A914Y353_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y353"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13662.t1">
        <property type="protein sequence ID" value="PSU_v2.g13662.t1"/>
        <property type="gene ID" value="PSU_v2.g13662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13662.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="30351" checksum="F43659BC602ACBA4" modified="2023-02-22" version="1">MDLVITVCDAAAAEACPVVFGDFIRSHWGLPDPAEAEGSDADKAAAFAHAHAIVKARVAGPAGTARARVARPRNAAAGAGPDRPPAAGSAHAMSTAAPMGLFERHLTLWVALCIIAGTLLGHFLPGAFASLAAAEVARPGGTERRDHGGGLCAGGGAAAGAVGHHRTVGYVAAVGRPVHHGSGAGGRVAAPLDPVAPWPARAAGGAAPAGPTVTVGTAADAGAAVRVPGPADRAAAAGDCIDRGPDPDPGLFHLRPGLPAQPAPGCGALRGRAVGTDRRQQLLRTGGCDGRGPVRCPLRRGAGHGGGSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3X6</accession>
    <name>A0A914Y3X6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MHD1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3X6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13483.t1">
        <property type="protein sequence ID" value="PSU_v2.g13483.t1"/>
        <property type="gene ID" value="PSU_v2.g13483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:synaptic vesicle membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:terminal bouton"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:syntaxin-1 binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:dense core granule priming"/>
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    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:synaptic transmission, glutamatergic"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:synaptic vesicle docking"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="64"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13483.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27225" checksum="D9E408AF82C8D6BD" modified="2023-02-22" version="1">MFDNCVDESGEPDKSVDFLKDLLDLTMRMIEEDKSIYTPVLNQFPQELNVGELSAETFWLAYRDDLKVALSEHAATKVCKTSDYMNLYFRVKSFYKNYVEKLQNFSSAIPEFPEWFNPFVMDWLNENDEHSMDILRNAYNVDKASGFLPSSAHSKFSNSVVDVFTQLNEALNVLCEMECPNPEVSADMMRRFAKTLNKVLLAYADMVQKDFVHYSKNEKLACILMNNVQTSRYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y674</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            </authorList>
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    </dbReference>
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            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14749.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21851" checksum="F7BADB5EC39FB8D6" modified="2023-02-22" version="1">MNNNALISFDKSLQKNPCQLQAFSLPSNLIYYISKNPLFFSVKVYQKLIQTCKYFYLKKRIIVINKLESSQNPFIWEAYEKLNGKEYIKLDIRNLSFDLWLIGELNVCRQIPAGFVNLLLQKVVKCDITSIYLYNYMLNFNEFLVLTESKKIKHLALEEIIVRDNDGKVVPYEDILQRVPNVSYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y691</accession>
    <name>A0A914Y691_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y691"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14281.t1">
        <property type="protein sequence ID" value="PSU_v2.g14281.t1"/>
        <property type="gene ID" value="PSU_v2.g14281"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
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        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
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        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31507:SF12">
        <property type="entry name" value="C6 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31507">
        <property type="entry name" value="PROTEIN CBG15923"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="92"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14281.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="39639" checksum="6AC32CFA86494FFD" modified="2023-02-22" version="1">MRSEGGAAVNCQLIGVWGNWEAWTACPVNPPIPLLNIQRRLRDCIPQPPNCTEITQYNCNGPYSEVVNCGSTTLPSTTTTSTTALPTTTSIIVPSTTSTPTTTTTPIPTTTSTTTTTPVPTTTTTTTPIPTTTSTTPVPTTTSTTTTTSTTTPIPTTTSTTTTTPRPTTTSTTTTTPLPTTTSTTTTTPLPTSTSSTTRAPTTTSTLIPITFTFPPTSTSTTSTTTTTTRAPTTSSTTTTTTPTPIVPTITSTLAPTSSTSTTTTTTTTARPTTVTLAQPAGPTTTAEPGDPACAGTQWNNWLEWSNCTDICGSCGTHQRFRVCNKAAPTCKCPGTAIDKGVCNTAVCKYPRASPCCDNYAPFSQDGQFVCLLNSTISTQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6A7</accession>
    <name>A0A914Y6A7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6A7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14981.t1">
        <property type="protein sequence ID" value="PSU_v2.g14981.t1"/>
        <property type="gene ID" value="PSU_v2.g14981"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14981.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29851" checksum="4BD6E73BD1C63CF3" modified="2023-02-22" version="1">MQQQQLPLVKLLEKINVHAVDAQHAYTFLQRKRDTYASSESVSDGKLRSPANKKKKDGFAKISDNDSSVKIVSSSQKKPKVEVEEMENNAMRNTRTFLKHHVNDFYSFNHRPVDAVTIPLGCNMWFNTVNNNRSTISSRIFKSDFIDLLPALGIKRSCFGTTTDEALFLVHRVDKSTVKVFAVGQAFSDNCINEIFLHSACVARDQSDDVSITLFLQDDCGDLPSKLIVLSTFNIMIHEDPSATPLRIENLIPPQNVDVDYLQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y788</accession>
    <name>A0A914Y788_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y788"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15317.t1">
        <property type="protein sequence ID" value="PSU_v2.g15317.t1"/>
        <property type="gene ID" value="PSU_v2.g15317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15317.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10410" checksum="31626DA16699AAE2" modified="2023-02-22" version="1">MLSKVPRITCYFDIASAHCWFAFEELLSYHKSTNTPVNFVPVHAASIMNTIGHKIPYYEKTLRDYNFYEVETLGKLYGLNINPPDDAFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7T4</accession>
    <name>A0A914Y7T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7T4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15515.t1">
        <property type="protein sequence ID" value="PSU_v2.g15515.t1"/>
        <property type="gene ID" value="PSU_v2.g15515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15515.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="15010" checksum="542E7374208D05C8" modified="2023-02-22" version="1">MAPHRKLKDQRSLQHQIHITKLEKEIKYAETDDEKAKIYDKFAENFLMPKELWIKRLKFVVKKEMDGYTEDFSRTLMDKKNVAEKIQVLLNAIQHLYYDREAINCKVCLFFDVWEDFIDSFDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y850</accession>
    <name>A0A914Y850_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein assembly factor BamC</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y850"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16373.t1">
        <property type="protein sequence ID" value="PSU_v2.g16373.t1"/>
        <property type="gene ID" value="PSU_v2.g16373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.170">
        <property type="entry name" value="Outer membrane protein assembly factor BamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042268">
        <property type="entry name" value="BamC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010653">
        <property type="entry name" value="NlpB/DapX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06804">
        <property type="entry name" value="Lipoprotein_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16373.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12318" checksum="70E5F82530FFA0D7" modified="2023-02-22" version="1">MLNESFDRAWRRVGVAIDSAGFSVEDRDRSAGEFFIRYLDSDTGEKIEQQNIIGRIFGSRNSAEATPFRIKLSAQGAGTRVTVLDQQGQEQTTPTAKRIINVLSTNLRPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA96</accession>
    <name>A0A914YA96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase Tc5 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16350.t1">
        <property type="protein sequence ID" value="PSU_v2.g16350.t1"/>
        <property type="gene ID" value="PSU_v2.g16350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cystatin" evidence="1">
        <location>
            <begin position="33"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16350.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="23044" checksum="646E96D5BD8FD6AF" modified="2023-02-22" version="1">MWCICYPFRRYNDIWVPYGFRTRVFREHNVINHCTKQIYEIVKKAIKEYNEWSTSPYYWFIAEIHRAHTAHAEDNKYKIEVTIGLTSIKKNRISQRWLIFPSLFERDKSLREDIVINYTRPGAFGWRTYHEEISFETPPYDRLKCNRRLKYLGECNRLNCQPDYQFYFLCKNHFCLKCFFNHADFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAS8</accession>
    <name>A0A914YAS8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17308.t1">
        <property type="protein sequence ID" value="PSU_v2.g17308.t1"/>
        <property type="gene ID" value="PSU_v2.g17308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513:SF19">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="3">
        <location>
            <begin position="47"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17308.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="23516" checksum="E83293E6D4EC1279" modified="2023-02-22" version="1">MAAPAAPPAAAKSQAAPPAAPPAGAPPPSSPAGANLGQNKENEPQFQMKLEPESKVVFKGDKLAESEAVVPVKLTNTTKARQCFKVKTTSNDIFRVRPPLGFVAPNETVTINIVFAAKEVPAPNRHFFAFYHIPCKDDDKNPRAVWGPSAKPEGVRRIVTDFVKEDGTAVTADKNNNAAASPTPPAAAPAGGAPPPAAAAGAAPAAAPAKSAAAPPAAAPPAAAPAAAAPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC85</accession>
    <name>A0A914YC85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC85"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1509.t1">
        <property type="protein sequence ID" value="PSU_v2.g1509.t1"/>
        <property type="gene ID" value="PSU_v2.g1509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1509.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31149" checksum="928AEAA794F50857" modified="2023-02-22" version="1">MPIAWGSYPSKIVKFFVVAGLQQDVLIGTNVLQNDTCWIEALEIALGYGAQDADPDNKRNGMGIGYIVPQNGLNEACSSREKVNTVSLYRNNCKTVSLSRDNFNIVSRASKNFIVKDGKSDSQRPPKETTTVMQGAKHHQVKKRTKKVTAPPYVPKKPSRGNPYQQLIKKPTELSTSGNSNVNVKKCDASVCRVHHYKRRTYFNSHYVFSHGLYYMTAYRNDYPKDRRTNKESVSKSSANVDPNWRNHVPVRGGYKPKWRNESADAHPSNQHNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCZ2</accession>
    <name>A0A914YCZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCZ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17164.t1">
        <property type="protein sequence ID" value="PSU_v2.g17164.t1"/>
        <property type="gene ID" value="PSU_v2.g17164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17164.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30646" checksum="91AE6085068C0DC9" modified="2023-02-22" version="1">MSRENIIYVNSLGKELSFYLTSISSPISSLPIIEESLNVETPIGATLFFQKLQSISPFSSLKGLVFIYCHPPDLCHSFYHFRQRCRQICKENGILCHFSFIKTFMAFVGLTMSKVKVFDGETIILASPRGDPVTVWSIIFRDKKYFIEDYRTLPWASNPYNWRNEVIGFRDPNKIVFLRISSESNLRNLVRAFKDMNPIIPNSTYVGFIAKAVVELIQGIAGEISHHYRVIPLIQDLFLATETKALGKISDEFHQPFRFHPTNVPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD93</accession>
    <name>A0A914YD93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SLC26A/SulP transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YD93"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16718.t1">
        <property type="protein sequence ID" value="PSU_v2.g16718.t1"/>
        <property type="gene ID" value="PSU_v2.g16718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="58"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16718.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20139" checksum="F229395D1DFC7DA9" modified="2023-02-22" version="1">MNQIEFNKVYGRLPPGYGKISTIQKIRKNLTPKWFKNKIYGTIPILEWLPKYDFKKCFFRDLIGGLTVGIMHVPQGMAYATLAGVEPIYGLYSSFFASLIYMFFGTSRHISIGTFAVASMMVGSVRFRLIPESIDSVNVHSAADGILGSNVTTAINHPLINNNYEVMTLLSTLTFGVGIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDA0</accession>
    <name>A0A914YDA0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YDA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17415.t1">
        <property type="protein sequence ID" value="PSU_v2.g17415.t1"/>
        <property type="gene ID" value="PSU_v2.g17415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17415.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15372" checksum="5892C5C412FFBA1C" modified="2023-02-22" version="1">MPEYKLSYLPIRYLAEPARLIFHYAQEEFEDERLSFDEWEPIKQSSPFNTLPLLTINGHQQIGQSMTIFRYLAKQFGLDGGTDFEDAHINCVAEYFREMMEKARPFVRFWNRGIVEETVVSNGSFFRKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEM3</accession>
    <name>A0A914YEM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the stanniocalcin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18718.t1">
        <property type="protein sequence ID" value="PSU_v2.g18718.t1"/>
        <property type="gene ID" value="PSU_v2.g18718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004978">
        <property type="entry name" value="Stanniocalcin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245:SF6">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11245">
        <property type="entry name" value="STANNIOCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03298">
        <property type="entry name" value="Stanniocalcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18718.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13630" checksum="5EC64972A9ECE411" modified="2023-02-22" version="1">MYGLKYCIRFNSQEYMEKFDKNGKIFLNCTTDCLLKSITEITRDEERKKLPDCDHLYHQAFKSHVQCYLECDFCNICKTNKAALLNAYDFKDFMSRAAVNQIYQVLKECGPFKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEM5</accession>
    <name>A0A914YEM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17744.t1">
        <property type="protein sequence ID" value="PSU_v2.g17744.t1"/>
        <property type="gene ID" value="PSU_v2.g17744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17744.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16832" checksum="DF0D539CF221A272" modified="2023-02-22" version="1">MLKSILRIINVDIVILGLKSSGKSSIAESLRQYLNLSQLEKHIYEIEYSEMLDVNEIITKIKNTNSKIYIFVVPNTVGRMDAELSKYLINSNKNVCIVLNKSDEMIDNLKKQQNFFGNDDYVKKRLEAAQREFIKHFCAHWIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YET9</accession>
    <name>A0A914YET9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Paraquat-inducible protein A</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YET9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18787.t1">
        <property type="protein sequence ID" value="PSU_v2.g18787.t1"/>
        <property type="gene ID" value="PSU_v2.g18787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007498">
        <property type="entry name" value="PqiA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051800">
        <property type="entry name" value="PqiA-PqiB_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30462:SF3">
        <property type="entry name" value="INTERMEMBRANE TRANSPORT PROTEIN PQIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30462">
        <property type="entry name" value="INTERMEMBRANE TRANSPORT PROTEIN PQIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04403">
        <property type="entry name" value="PqiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18787.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13942" checksum="BE2598D2F21B838F" modified="2023-02-22" version="1">MERRLLSRRCGDLSGQYYGANVKDDRHRVAVLGMPKGHGKRDSERMHLIYEVVEFVGRWSMIDVFVIAVLSALVRMGGLMSIYPAMGALMFALVVIMTMFSAMTFDPRLSWDRQPESEHEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF19</accession>
    <name>A0A914YF19_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein okra</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YF19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18050.t1">
        <property type="protein sequence ID" value="PSU_v2.g18050.t1"/>
        <property type="gene ID" value="PSU_v2.g18050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="215"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="502"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="688"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="694"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18050.t1"/>
        </source>
    </evidence>
    <sequence length="908" mass="103682" checksum="F7B515D9C2ECD3F6" modified="2023-02-22" version="1">MVKLLESTLHNKEAALNNASDPTTSHHAQSNKKTFMVCYDKASGRKNKLYRYDGFFEVINGNYGRFLDEGRQLLAQDHLDKHTVEEIEDFGPFVFDNYDIESHEEIKSIYSAREAIVEPPLKTFSDFQKVEPRTMQKPVNYQIKETFPKSFKEGAPIFRSLVKNVSSIAKPEQIHHDAYIIQEPNERYPNGVKIAPILAKVMRDHQKEGVKFLFNALHKGDNGAILADDMGLGKTLQSIALIHTMVNTKLANKYKLINRVLLICPLSLRQNWLDEFEKWGIRNFCYIPSNKDEVERYIAISSRTPVCILNYNIVASYGKILNMSKFDLMICDEGHVLKNTTKIRKTLLDLPSQRRVILTGTPIQNTLKEFYQLTTFVHPTRFESLEDFAQQIQEKKSDAFSSFFLRRTAEVNQKFLPPRHDFLVFCQPSPLQIEVYGKALDVITANTFSMFNAFRQICNHPALLYKNVRTPEYIDFARCFNVYPIDYDSVNLKCEESGKLATLAAMVVNFRNESDKTVIVSQSTQCLSLIGQLVKALQFKIYRLDGKTAPEKRQKLVTHFNGSDDPNDIFLLSTNAGGVGLNLIGANRLIMFDCSWNPASDFQAMGRTWREGQKKKVYIYRLFTAGTVEEKFLQLQIKKTGLATIVNPWAAWKNKNKDIDLDELKNYDEFAPGVACDTHDSIKCDCEGNGNTERDEDDDWYDNDDVDMDCDDDGTGAEEDHEGMDEDLDDFHVNQDKSNVYARISLDQLYKWHHHAHGSKSFNKILDACGLFDDTPVSFIMETEFIPPGSNNDAVEEDSASFQDVTEEYQDSTQSAVEEYDTPIVSQSDKVLTSVDDEENSDQLGDMFVDENPEVAYNNTNEIDNEHILTPLMAKHNESTAEDFNTTAEIQNVTTSQSDYTLTNYLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFE4</accession>
    <name>A0A914YFE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ankyrin repeat domain-containing protein 13C</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16086.t1">
        <property type="protein sequence ID" value="PSU_v2.g16086.t1"/>
        <property type="gene ID" value="PSU_v2.g16086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="9">
        <location>
            <begin position="156"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16086.t1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50938" checksum="126EA7DC78C18424" modified="2023-02-22" version="1">MVEYDNEKFPIHKAAFHNDVQTLSRLLSEGEIDIGAQDPHGNTPLHIATMLGHKEAITLLLSKNAPVKTKNSQGYSSLMEAISYGNRQTINLMLRKLKSQAREHLSSRKPHLMKVLGSIDDFYMEIKWDFHSWVPLLTRILPSDVCKIYKHGTALRMDTTLVDFNDRSWERGDISFIYNPQVEHLKQHLVVLDNKKKVYQKLKNSSVEKDIEEEVDVLMSSDIVSAQMSTKPITFQPMMAGWFFRHEKSDMVGTFSTNYYNVDNLNLVSKKRREHLTQDDIKNNKTYLQSFAHGKNIPDENDMKSFEHRPDLPPPAIPKVTWEEYIYSSEFVHLGRPMDVKINSKSFKAGIGLSPEFPLGVNTLIDILEVIAPLKHMNKMRHFCEGRMPHGFPVRLEIPLLPTITAKITFQKFQWCDNLSMKFFRVPRSYTEDTNRFPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFR6</accession>
    <name>A0A914YFR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GP-PDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFR6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18294.t1">
        <property type="protein sequence ID" value="PSU_v2.g18294.t1"/>
        <property type="gene ID" value="PSU_v2.g18294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18294.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7805" checksum="2132A13A59DA9544" modified="2023-02-22" version="1">MYMEFCNLTLSFVPTFVQQQKSAGRHVCAWTVNDLTEMNWMRQTLSIPVLTDKPFLIDQMKGHGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFV6</accession>
    <name>A0A914YFV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFV6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19182.t1">
        <property type="protein sequence ID" value="PSU_v2.g19182.t1"/>
        <property type="gene ID" value="PSU_v2.g19182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19182.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8942" checksum="B1DA275EE1826583" modified="2023-02-22" version="1">MSIKCNQEDDIFTTKEKSGPITLDIPFNEALADYEYDNDVRIQIEGRYDALIIERTDEENMEVSLSARFFRYKVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFZ3</accession>
    <name>A0A914YFZ3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L22, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17686.t1">
        <property type="protein sequence ID" value="PSU_v2.g17686.t1"/>
        <property type="gene ID" value="PSU_v2.g17686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17686.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="31456" checksum="4D1C9065810FE30D" modified="2023-02-22" version="1">MLSVRSIGLQIFCRNALPSIASYSTEANDLITLDDQKRSKLEKWKNREQFTKSTIQRFEELPVKNFYAPDWDIQQFDNDKELYARQRCLTTPEKWEYYNKVVWNPNHIVPETGLPKAREVFHCRESIHYQPKKIWPACQFVRGVNVDTAIQQLRYKQSKSCIMLADIIEEAKERAKNEFHIVESNKMFVAEAFPIQEKMIKGARRHARDAWFPIRYRYIHVFVRLEEGDARDLGTRVRHKDGWEKMEDYYDYLRSRDFKYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGX9</accession>
    <name>A0A914YGX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18047.t1">
        <property type="protein sequence ID" value="PSU_v2.g18047.t1"/>
        <property type="gene ID" value="PSU_v2.g18047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18047.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18414" checksum="EF0D5D06CDF0CA8D" modified="2023-02-22" version="1">MTPLLRQKILDAMNNARQTVKNGQMLLSEGEYALPAAEMPDLVWNCEKEEELHEFLQDYCEAYPFMNGNFPTQINLLDISWNHFGLDVSDYDTFIQNGITINPTFGMFTSNFMAHSPIFTGSSRLDVYYSKAETLACAMYDCEVGNKVGNGYPAYNTNYVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHL3</accession>
    <name>A0A914YHL3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YHL3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16795.t1">
        <property type="protein sequence ID" value="PSU_v2.g16795.t1"/>
        <property type="gene ID" value="PSU_v2.g16795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035095">
        <property type="term" value="P:behavioral response to nicotine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14089">
        <property type="entry name" value="STKc_MAPKAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000156">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1170.10">
        <property type="entry name" value="MAP kinase activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027442">
        <property type="entry name" value="MAPKAPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16795.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39845" checksum="1560D5B05CD84CE7" modified="2023-02-22" version="1">MNMVVKFKTNPIKEDYIIGSQVLGVGINGKVVECRRINDGEKFALKVLRDVPKARREVELHYEASRHPHIVRIFEVYENTYNNVECLFVVMECMEGGELFTRIQERSNDAFTEREAANIMYSICSAIAYLHGLNIAHRDIKPENLLYTDPSNHAILKLTDFGFSKRLDDGTEKPLETPCYTPYYVAPEVLSSKKYDKSCDVWSAGIIAYILLCGYPPFYSHHGLPISPGMKKRIRAGQYNFVGPEWDRVSEAAKDLIRKCLKTDPAERSSINDIMCHKWITHYNKIPETPLETTKVLQEQRLQWPEVQEEMEKALASMRVDEVHIKSLNDAKNTLLAKRMKSSGHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJI4</accession>
    <name>A0A914YJI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ERAP1-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20500.t1">
        <property type="protein sequence ID" value="PSU_v2.g20500.t1"/>
        <property type="gene ID" value="PSU_v2.g20500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="2">
        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20500.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24412" checksum="69084F5D43CE71D0" modified="2023-02-22" version="1">MYLSLKIYLTKHAYSNAEHTDLWKALTEVVPNNLTSWTGEKFDVDDFAKKWTEQMGYPVVTVSTTTKGVQLSQKRFKMDENSVESSRFKNAKFWYKWDVPIWYTIDGESHPMTWLHTESELNLSNSKDLVFVNSDSDGFYRVKYDDEQMAKINQQLVQDHSKIASRSRARYIDDAFTMAQAGQISYENVLEMSRHEWFAYYCRIFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK63</accession>
    <name>A0A914YK63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK63"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19719.t1">
        <property type="protein sequence ID" value="PSU_v2.g19719.t1"/>
        <property type="gene ID" value="PSU_v2.g19719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19719.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="21472" checksum="63371560DF575702" modified="2023-02-22" version="1">MRAGRGDADQHVAGGHAGAVLQLALLHRGDREAGQVVLAGGVHVGHFSGFAADQRTAGLGAAVGDAAHDRCGGVDVQLAGGEVVQEEQRFGALHQHVVHAHGDQVDADRIVAVQLVGQLQLGAHAVGTRHQHRLAVLVGQVEQGTEATQAAHHFRAEAALDQGLDPLDQRIAGVDVDPRVTIGKGGGGGRRGVGHGRRRWQGLNGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK73</accession>
    <name>A0A914YK73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19927.t1">
        <property type="protein sequence ID" value="PSU_v2.g19927.t1"/>
        <property type="gene ID" value="PSU_v2.g19927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19927.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10604" checksum="3CBF7E6299401649" modified="2023-02-22" version="1">MDAAFFHCKDCVRLTANRQRTKGHIKFINGDIEVREGRHYPTCRAYEIKEIPKALPENERPDDIVVVGDIDMQDVEEPSPIVKYDFNKTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKI5</accession>
    <name>A0A914YKI5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pellino FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKI5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17823.t1">
        <property type="protein sequence ID" value="PSU_v2.g17823.t1"/>
        <property type="gene ID" value="PSU_v2.g17823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF2">
        <property type="entry name" value="PROTEIN PELLINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="2">
        <location>
            <begin position="41"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17823.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15214" checksum="6E03B7C2BB323343" modified="2023-02-22" version="1">MPTTPTNNENDKLSSEGENESPSITPTHVINSILEEVLDEPENYGELILLGYNGAPETPRHHSNSRRCHRSKMVIKKKDFGNGVKKGKMISIQAPPSQSSVVQDSSRHVVSYSYNKQHTVLVEYVNDSTKDMFQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKW7</accession>
    <name>A0A914YKW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKW7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20178.t1">
        <property type="protein sequence ID" value="PSU_v2.g20178.t1"/>
        <property type="gene ID" value="PSU_v2.g20178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20178.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11711" checksum="BA8B9FCEFD0D6705" modified="2023-02-22" version="1">MATLGPITPLIYQILYLIGDSTVDVSIPVLYTLYDLSLIMCEMIFIYSIFKTVYQNKKATSTVSTAYIKQEPQQHVQTALGTYLPTLQTVEDYFVELRNTWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLI3</accession>
    <name>A0A914YLI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PWI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLI3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18181.t1">
        <property type="protein sequence ID" value="PSU_v2.g18181.t1"/>
        <property type="gene ID" value="PSU_v2.g18181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="328"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18181.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="51490" checksum="75226D490B274582" modified="2023-02-22" version="1">MMFERREKERERDRSRRRKHHSKERSRSPRRHRSRSRSPRRSSRRDRDRSPKSERSSKKSRKQKHSDTEEDEAKKRERQKRKEREEMYQRRLKKWEDKEVRFAREVEKDREKERQRRKGAEKEAKKLQLFHENYDDDVNDQKYYRGDLLIQRRRMLEQQLELDRKDREIEEAEFEKMKSEIMASNPENFTNVEEEARKRKENEETKMNIKLGIKSSPVVPLSITPDEDDDSRPAQFKVEPQNSGWESVDSPSVSLKVPSLAKKINVQTARVTTNGLFADDVDDEEEAKKKRKLQPFIISSEERIAVLTPDERKRMIRDLIDKIPKSREQIFAYPMKWEYLDDAMIETRIRPWIAKKIQIALGEQEPDLTTFICECVKKRSDPKKLVLDLSMVFDEEAESFITKMWRLIIYETEARYKGLSALPSAIPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLR5</accession>
    <name>A0A914YLR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLR5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18262.t1">
        <property type="protein sequence ID" value="PSU_v2.g18262.t1"/>
        <property type="gene ID" value="PSU_v2.g18262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF345">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18262.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14822" checksum="B967C444588F1842" modified="2023-02-22" version="1">MNKLGPNEKAKNEAVAEEDSDDLLKFPLSFLILITILWILFCAWIFTFFETEWGYGTSLYFTLISFLTIGFGDVLPSKSDYIILIGILLLIGLALVSTLLQIIQKQIETLATVILTTFFNQFIDKKFEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM64</accession>
    <name>A0A914YM64_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YM64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20667.t1">
        <property type="protein sequence ID" value="PSU_v2.g20667.t1"/>
        <property type="gene ID" value="PSU_v2.g20667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20667.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12502" checksum="2CBC8E0ABF969595" modified="2023-02-22" version="1">MAIGIVILSVCIFLAGIMVSKEQKVLDIRREHPYAILIVLVGIAYCFITYLPFVIIALFSLCFPLLLVLIHASIRLRGVNNKLNQKFFEGVIRETVMAKILRVLNVEAKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMA3</accession>
    <name>A0A914YMA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21468.t1">
        <property type="protein sequence ID" value="PSU_v2.g21468.t1"/>
        <property type="gene ID" value="PSU_v2.g21468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21468.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8988" checksum="047A5203E4F2707A" modified="2023-02-22" version="1">MEDLTLRGKTISYFENINLAQVKSVIRAIAHMHKNVLTADPSLWRGKFLKNQTVLADVSNVLHSMIEPLIKKSKREGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YML8</accession>
    <name>A0A914YML8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YML8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20832.t1">
        <property type="protein sequence ID" value="PSU_v2.g20832.t1"/>
        <property type="gene ID" value="PSU_v2.g20832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20832.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11946" checksum="5F22035537612374" modified="2023-02-22" version="1">MGPKLVQGAAHGSDIVNLFGGLYIPIKMDESGKKVQKKFINLIANFIKNGTPSTDSITVPAITPESFQYIEVGAETIVKKDLWKDRLEFWNRIGPKYGYDLAAGFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN16</accession>
    <name>A0A914YN16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YN16"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20339.t1">
        <property type="protein sequence ID" value="PSU_v2.g20339.t1"/>
        <property type="gene ID" value="PSU_v2.g20339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20339.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18591" checksum="AAADE6F7380B001F" modified="2023-02-22" version="1">MAAAPFIGALSRKINSGPLSDKLTIISQQKRCIVFASISQFLMAFCIFALGWMPIKNKIFAKIAFTVAIMASSLNVVGVVKSAQLQSRQHAHVIMTVIAFINSAIVLLLPLFVSTLSPNNSPTEWPKIFYLIAILVTVTTIIFNFTCETDPRPWTHSNTSHDRKEPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN70</accession>
    <name>A0A914YN70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YN70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18776.t1">
        <property type="protein sequence ID" value="PSU_v2.g18776.t1"/>
        <property type="gene ID" value="PSU_v2.g18776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45886:SF18">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45886">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18776.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18750" checksum="7ECF6745CBB7CAE8" modified="2023-02-22" version="1">MLAIFTQVFYSFQSHCDTITLPNGTMPMRCMKEKNRLELECFCRCIEPVERSQITTEEYVLAKAIAVCNPAIPELSFNAQKIVEKQREYYANILFKHEQNSYGIEGGAVKYTKIMSAIEAMYHFAQRQREFHNICRMQFLIGADNPWPNTCKLKLFEDSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQC3</accession>
    <name>A0A914YQC3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21235.t1">
        <property type="protein sequence ID" value="PSU_v2.g21235.t1"/>
        <property type="gene ID" value="PSU_v2.g21235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000001">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000079">
        <property type="entry name" value="Ubiquitin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="499"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00071717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21235.t1"/>
        </source>
    </evidence>
    <sequence length="543" mass="57221" checksum="BBDC93D0D275EB5F" modified="2023-02-22" version="1">MADSGSEDEQAPQITITLKSTAENHQISIADNATIGKVKKVLSEKINQPVEKICLIFSGKILKDHETLKTYNINNGMAIHMVIRAAPSSGSSTPASRPSAAASTTTPSGGGISSTPTTTSSTPAAPTIPGMPAGMNMETARRLMDSPFMQQMMNNPEILRNMIGGNEHIQSLIRQNPEIGHLLNDPEIIRQTMEMIRNPNMFNEMMRNHDQAIRNLQGIPGGEAALQRLYTDIQEPLLNSANSGSNPFASNNDASAESRSQRAGVENAEALPNPWGSGGGRTAAGSDSAGTGGTGAAAGSGGGGMPNMANMLNNPALQSMMNSPEMQETMRSMMSNPEMLRTMMSPEMLQQARGLLGDNIGSNEEIARMAEQMSGLMGNPDVASSILNPRVMEAMNNIRTSIETIRTEAPGLFQQMFQGVLSSMNTMQNPGTTSASSQNTTSNTATDAAAGTGAAGANPMMNPQLLSMLGALSKLVKAKKKEGNPAFGGAAGGAGANIPPEERYRSQLDQLVGMGFSNRDANIRALQDTNGDVNAAIDRLLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQC7</accession>
    <name>A0A914YQC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19569.t1">
        <property type="protein sequence ID" value="PSU_v2.g19569.t1"/>
        <property type="gene ID" value="PSU_v2.g19569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19569.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="15054" checksum="A7EE338CF6B4173B" modified="2023-02-22" version="1">MNPDETERHMNIRADSLRPEGKRGALMSFLYPAMYTVTCRLNIRYFPYDQQNCTLTISSWTNSKSALDYYADENVNLASYISNEEWEVISFKVYRHEYKYACCPEPWVILEASIVIRRKPLYYVVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQI3</accession>
    <name>A0A914YQI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Malic enzyme NAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQI3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2283.t1">
        <property type="protein sequence ID" value="PSU_v2.g2283.t1"/>
        <property type="gene ID" value="PSU_v2.g2283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004470">
        <property type="term" value="F:malic enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000055">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="2">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2283.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28050" checksum="1B571554299B0A76" modified="2023-02-22" version="1">MIISQTQREGLSEEAARQKVFMVDRFGLLTDKMPNLLPFQTKLVQKRENLSDWDTDSDVLSLLDVVRNVKPDILIGVSGQTGLFTEEIIREMHKHCPRPIVMPLSNPTSRVEATPQDIIAWTEGNALVATGSPFNPVVWKDKIYPIAQCNNAFIFPGIGLGVIASGASRITDEMLMSASETLAQYSPLVLNGEGMVLPELKDIQKVSRAIAFAVGKMAQQQGVAVKTSAEALQQAIDDNFWQAEYRDYRRTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS42</accession>
    <name>A0A914YS42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2472.t1">
        <property type="protein sequence ID" value="PSU_v2.g2472.t1"/>
        <property type="gene ID" value="PSU_v2.g2472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2472.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25042" checksum="1FB37EF48325A726" modified="2023-02-22" version="1">MFISTTPEPFLLPSFPKSDFPVIDASSSNNQQQMALSAFGLPLSMLPQPKPVAIISTSNSKGGGDLLSQLGAHPSVEKELRQLASRFGFDTNKIPDPTTLNMLKRFLGPKMPNLNFGTKIAEFNSNLHGNGVSQNLRPIKPVNVDSEDFERVYKEESLKRMFSPSSSSSTALSSSSTKVAQALNGEILKSFASVIQLPSNSPDPQLPFRQKNLDFAYQNALSSSSSSSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSE2</accession>
    <name>A0A914YSE2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the CIA complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSE2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2571.t1">
        <property type="protein sequence ID" value="PSU_v2.g2571.t1"/>
        <property type="gene ID" value="PSU_v2.g2571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2571.t1"/>
        </source>
    </evidence>
    <sequence length="487" mass="55739" checksum="87C70BD234070801" modified="2023-02-22" version="1">MGFAVLKDEDNDIIAQYALEIKEKKKSILQFIETLKEDFSNIDTQEYGLTKLFYVLQKLSNDCLEEDEVGSLLEFFLTRLEGSALRNGCVVTGIHHLIIHSKNLPAGCEVPIFQSIYSESTVQCFTQPVRTELFEILDFFLKHRRQGLKSLGSEFILCFMRAANGERDPRCLLQIFQLYLDVVKDFDLGVYCEDFFELLAVYFPLEYTPVGLFFFFYCFQLISSKLFEEETEEDMKVEICGFLAKAAGTFPSAPMKPFLDDFLTVFRRLCLNPSDKTSNEIPAKIQDAIMSTLKAFDKDVETIKSIANTMAENCEPFILQAEMGLTGKALSVLSVVSKGSKIAAEIILPQIMFWLGNLINADTVNAPQNRQEIIIEAINFLPDWLTLSIDCECTPVVRDALPGFIESLKRTEEQFGGVVYPVEYKISEILLRQSLKFKGVALPTKELYEKLVWRSVTDLKKMIQNYELQFRILLLLLQNLIFKHWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU01</accession>
    <name>A0A914YU01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20936.t1">
        <property type="protein sequence ID" value="PSU_v2.g20936.t1"/>
        <property type="gene ID" value="PSU_v2.g20936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037769139" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20936.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="7976" checksum="032753FA336FBCC3" modified="2023-02-22" version="1">MASIFALLLVLVVITFAFGDLFENPCGKLFMKDAHENCGSKISLPLCKEIISKCCGSNGRCPMTEVLKCCNNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU34</accession>
    <name>A0A914YU34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU34"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20973.t1">
        <property type="protein sequence ID" value="PSU_v2.g20973.t1"/>
        <property type="gene ID" value="PSU_v2.g20973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20973.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10996" checksum="DDAC6E822F45E752" modified="2023-02-22" version="1">MYGILMALQFANNESPKLNNFQIVCDSPIFVKYYKREWKKNNGEPVANYHFYKQIVKLADELNVSFCYLPENSEHPDFLSAKLLAQDGLGMPFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUA5</accession>
    <name>A0A914YUA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUA5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g325.t1">
        <property type="protein sequence ID" value="PSU_v2.g325.t1"/>
        <property type="gene ID" value="PSU_v2.g325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1560:FF:000001">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050343">
        <property type="entry name" value="RsuA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683:SF3">
        <property type="entry name" value="RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g325.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12477" checksum="C7FB58EAAA4F3A7A" modified="2023-02-22" version="1">MHPRYGAEREYAVRVLGELSEEQMQSMRDGVQLEDGVAKFGMIEFLGGEGSNRWYRVTIHEGRNREVRRMFEAMGVTVSRLIRTRFGDVGLPKNLRRGRWEELDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUH2</accession>
    <name>A0A914YUH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3636.t1">
        <property type="protein sequence ID" value="PSU_v2.g3636.t1"/>
        <property type="gene ID" value="PSU_v2.g3636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036688700" evidence="1">
        <location>
            <begin position="24"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3636.t1"/>
        </source>
    </evidence>
    <sequence length="543" mass="61646" checksum="6283A2CF0BD26266" modified="2023-02-22" version="1">MAFISEIPCILLLFSIFVLNSSAQQYMRPAMEVDKIETVDVTPSQIIITTTKVGPVESLHIYVDVIDIEKGEHQPAMNLSGLLLLITRGRYTVNFLRPGTWYGVAFYSEQKPLGDHGQTYLNFEEKLVRTLPSPEISADSEEEALKVPPMEVTTRRMNEKGKSIENLLVALKWTLPRKYRTNLQAVANISLHCKDHIRYKELKLADEESEKSVEVKLDNSFNITENRNSSREIVANIQPKNCHRICWDTSLMASFDQHHFGHAISSDCRNIEPVTAKANIREYLSYDVNHGDLIIRTNATDTNEMEDAIVDIKAIELPEGAKNDSNATQISQVFGTNSSDPTFVLHDLNPQKWYAVEYIYLKRSPFNYVESRRFIVESRASTAKPPFRVRFITKDPKNNSTSSNSTETVVRPRILMVMDPGYKDAEIGIDVDPFCNAKGPNSSQHFWINARNPQHELKGLNILGAVCGEKPEHSLCGGKKDDSSHDVPGVTNRTTCNSPNLCYTGNLKIHEKVYSMKRRCLKKPNKRPKLLHLIQFFHSPLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUK4</accession>
    <name>A0A914YUK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUK4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4305.t1">
        <property type="protein sequence ID" value="PSU_v2.g4305.t1"/>
        <property type="gene ID" value="PSU_v2.g4305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="41"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4305.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36068" checksum="34FC3B655CC1F349" modified="2023-02-22" version="1">MGQRGGGDTQVQDSTGNNKRLWATQSFYNVTSFVDHNYQLMTCAQLIAVTQHSTVHKSYSKVFGRFVAIKIIDKKSIPSFLVEKFLPRELEITKRVNHPHIVHCLHIAQPQPTKVVIIYEFCDGGTLLKYVLDYNGLEEKEAARLFRQLIDAVYHLHFELSVAHRDIKLENILLDSNKVLKLADFGFARKTYKAEKSTSYCGTRPYSAPQLVDHIPYEAFAADWFACGIALYTMISGFWPHEPWEKISYPVKFTERISPSAKNLIERLIEKDENKRADFKECINSEWLRKHTADGSWIVPQSTSTVYPNWKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUK7</accession>
    <name>A0A914YUK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3670.t1">
        <property type="protein sequence ID" value="PSU_v2.g3670.t1"/>
        <property type="gene ID" value="PSU_v2.g3670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3670.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13095" checksum="4D96309F3DF7DCA6" modified="2023-02-22" version="1">MASVNRFEGKVVVVTGSSAGIGRASILRFAKEGASVVVHGQSKEKLESVKKDLLGLKVDESRILVIAGSLEDEATQNRLIDETVKRFGRLDILINNAAIPGKAGCDPNSMEGFDAVMIVNVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV27</accession>
    <name>A0A914YV27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV27"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4454.t1">
        <property type="protein sequence ID" value="PSU_v2.g4454.t1"/>
        <property type="gene ID" value="PSU_v2.g4454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4454.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="8515" checksum="D8FB62AFA070CD05" modified="2023-02-22" version="1">MYGGDGMYGGGGHGHHHHHHHSHEDYGHGGGMYGQGMYGGGMSPYYGRGGMGGMGGGMPMGGGQGGVQGALQGAMMGAMMGAMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV67</accession>
    <name>A0A914YV67_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxypeptidase</fullName>
            <ecNumber evidence="5">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YV67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4492.t1">
        <property type="protein sequence ID" value="PSU_v2.g4492.t1"/>
        <property type="gene ID" value="PSU_v2.g4492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12670:FF:000002">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF418">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038168599" description="Carboxypeptidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4492.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="50746" checksum="DDA4CEA4B6C39BAD" modified="2023-02-22" version="1">MHFFVALILATFVGISFAVDEIKRLPGVKFNVTFKHYSGYLQVSKTHFLHYWFVESQNDPAKDPLIFWYNGGPGCSSLLGLLTEMGPYEINSNAKTLHENPNSWNKFASVVYMEAPAGVGFSFSSDGNTTTNDDQTAQENYEGIKQFFTRHPGFRNHSTFIMGESYGGIYLPTLTSQILDGQNDYPIKLEGIAIGNGLLSDSLNDDTALRYMYYHGLIDETSWTEIEQKCCNGCVESCSLANLTGVCESMVSEASQNNYGLNPYNIYDICDPNSKFNPKRFYAYQKGILPKRFYSTFFKDDTKTNGKACMKDTEITSYLNLPSVRRALNIPKDFPEWVECGGIDEYQKQYDDMTPFFKKILKAKIPILLYYGDVDMVCNFMQGQKFVAQLKLSLWMKQKAWKVNEETSGFITLYKGLSFATIRGAGHMAPGWKAPETSFLINTFVNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVU7</accession>
    <name>A0A914YVU7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7636 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVU7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3777.t1">
        <property type="protein sequence ID" value="PSU_v2.g3777.t1"/>
        <property type="gene ID" value="PSU_v2.g3777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056053">
        <property type="entry name" value="DUF7636"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24642">
        <property type="entry name" value="DUF7636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7636" evidence="2">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3777.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16920" checksum="8BC9D2BE5FB3A660" modified="2023-02-22" version="1">MIIPYPSFVVSIPHCYSAQFQEHYQKLKKDAGCIDIAIRLRKNTPLFYQYTICSRGTLESCQKLEEMLTPTLEYDEAGNLNFAEMKEVKSNAMKELLENVFGFIPPPMNELQHARTTAGRMGDTRRQRHISSDPFGLDGATDARHNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWM8</accession>
    <name>A0A914YWM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4374.t1">
        <property type="protein sequence ID" value="PSU_v2.g4374.t1"/>
        <property type="gene ID" value="PSU_v2.g4374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4374.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29586" checksum="8A6888A2CCC594A7" modified="2023-02-22" version="1">MFALQKFIRNRQQRNAAVIDPWRFQEENKNYRVFCGFLHVKPVVITFTVLKTFIIIWYVTSKIIQQTTSVMTLVTCFALFLIISSNAFLTIGVIIRKYTFVIPYLTICVMLILVLTLKLFIDVLTTANTKDTLEEAKLKKIFFQSLLIIVEIYSVYIVWKVFNYITDYYMEIEFCTTTKLAEARKLKDKEDEDARERRKERAELIKRQQMEPRRKPTFPQIAALMEEARTLPQKEERNLSENSSSSSDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYR0</accession>
    <name>A0A914YYR0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYR0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4771.t1">
        <property type="protein sequence ID" value="PSU_v2.g4771.t1"/>
        <property type="gene ID" value="PSU_v2.g4771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037340579" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4771.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16802" checksum="7ABB8ECF0B5E87D8" modified="2023-02-22" version="1">MNLTITILLFCLIISSTAALSLLDLHDDQIPLRTYSKDNVQNNDDGTISFKEYGDYDTETIQRGIGARSKSIPLIEAPVAMSNPIWKIFSRASDLYRIFRRSSNSINNRNAEFSNDSANNNVISSPFSLPSYQFAKKVTRNPKGFQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ29</accession>
    <name>A0A914YZ29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ29"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4889.t1">
        <property type="protein sequence ID" value="PSU_v2.g4889.t1"/>
        <property type="gene ID" value="PSU_v2.g4889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038077214" evidence="1">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4889.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24717" checksum="EB0A6D0C555A9868" modified="2023-02-22" version="1">MLIIYLLASLLFLIIPQTFATTEWFGDLRAQLNPPRSPPFYDVTYDDTDCPQGLQSNAIPDFVYFGAMIATLTVQEHTECLQHCNLEPKCHAVNFFEPMSYQEKGFCELLSETQFDNPRLMRPFRRAVYYEKIRCRRDEDEGADTVITKPAAAEERIPKDLNNQLNSRVPAARELAKMNSSGNEIKKPNASMAAMMKRLEAKVHEFNLRFRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ52</accession>
    <name>A0A914YZ52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZ52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5227.t1">
        <property type="protein sequence ID" value="PSU_v2.g5227.t1"/>
        <property type="gene ID" value="PSU_v2.g5227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5227.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40730" checksum="C0CC9AD4A575AD3D" modified="2023-02-22" version="1">MDYYSRIMLCDDLTTPLGIAFIILKCYIGYRICRTLFAFLSAVLIYLIIPLFRKPNFNRYKQRWTVVSGGTDGIGKAYTFELAERGLRKFFLIGRSEKKLEIVKEELEKQYEAKVQTYLFDFFDGDYKKLRADLSKLDIGFVVNSVGVGREYLERYGDNPAADWQLLKVNALGSAEFMSCVLAPMEEHGGGQIVCLSSSQGLRPIPLLAAYSAAKALLCFVSDCIDREYKTIQVQCLTPALIATKMTFYEDGSLFVVTPKKFTKQAVNSLGLVTTTSGCFNHEIQLLINHLFPWTILKYLMLPVYWHHQKRMVKLLGPKQETLTNSNAKQQQQQQQSIIINNNNLLQTENNLMRQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZX7</accession>
    <name>A0A914YZX7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZX7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g548.t1">
        <property type="protein sequence ID" value="PSU_v2.g548.t1"/>
        <property type="gene ID" value="PSU_v2.g548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g548.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9260" checksum="648FBA237FF1075E" modified="2023-02-22" version="1">MSSVSNSLQAGEWGNEEREGKMVFEKGIGFDLTIINESYGFQIFVNDERFCTFAHRDDPSDISGLQIQGDVEITGIQVTLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZZ0</accession>
    <name>A0A914YZZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3599.t1">
        <property type="protein sequence ID" value="PSU_v2.g3599.t1"/>
        <property type="gene ID" value="PSU_v2.g3599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3599.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23781" checksum="169094B126FF7FE7" modified="2023-02-22" version="1">MQQKDYREISAVPSSKPYVSHMQYKDSRGQSVTLFPAFRSVDTLHDISRIQSPIKLNTVPLISRNQDKWANKYHEIVREYGPSKDDPESLFLFGKDELYRSESAGNAELKPSMLHVSTETAPAPVNPNPPPAPPPPPPIPPRKTSIKYPFTRQPSIRQTYPRMRYIYAFPEEFRDWIAQPTFSRYPPSKDDAAPEYLPSKYPSSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z048</accession>
    <name>A0A914Z048_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z048"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3654.t1">
        <property type="protein sequence ID" value="PSU_v2.g3654.t1"/>
        <property type="gene ID" value="PSU_v2.g3654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052089">
        <property type="entry name" value="Ankyrin-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46071">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46071:SF2">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3654.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="30058" checksum="1794DBE05CC8B6E2" modified="2023-02-22" version="1">MAWKYWNKSDDDESMYDIGFSDSDPDEKGGPQSYVYKMQQQKFELFKLQNPENFDVKFEIEGKILYASKFDLIAVSQTMNSWLSDRWTTKDQSVIIETYTFDIFYQFLCFIYSGGCELTKENIFEIIDVAEFFDLQHLKDFCETFLMQKKSEIVNNENIFDMVDVAEKYSLTKFVKFLYCKIADGLDELFENESFLKVQKSYLLRLCQDTIDATPQEIFSASIVVMGFLKKSFENSVSKINSSIGIFGQIRFPAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0M0</accession>
    <name>A0A914Z0M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0M0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3816.t1">
        <property type="protein sequence ID" value="PSU_v2.g3816.t1"/>
        <property type="gene ID" value="PSU_v2.g3816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3816.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="13554" checksum="B73F5047F991F470" modified="2023-02-22" version="1">MPCESCPTQTGKNDWYNGNTPAATTGSTASAGSWARDMCAAPCICDAAGACYIPDAGQDPAITFYPHCPTPTTCFIAVLLSSQGQLTPVAGGAPFTSDDQFDENNDPRPVTDPQYLRAKSVGCAGCPVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0T4</accession>
    <name>A0A914Z0T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0T4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5492.t1">
        <property type="protein sequence ID" value="PSU_v2.g5492.t1"/>
        <property type="gene ID" value="PSU_v2.g5492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06669">
        <property type="entry name" value="PDZ5_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000070">
        <property type="entry name" value="Multiple PDZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="196"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5492.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34241" checksum="D3949EC5CE00B6B1" modified="2023-02-22" version="1">MLHEQENDTQIVDVQSTLLDYKHSWQTKLGPDFEVISVIIHPDKNDIDGGLGNIYLLYACVKDGPAAKCGLLKAGDELLQCDDQVLYGESHVTVRHALGKAAAGTAQKDVRLILCRKAQQINLYMPSPEQSLPLAYTLLASDGMDRIVKAKSESSLNNLYTKQNGGYFLNEVAKRLKPRSLEHLSGLCIWNCVPIVVSLEKDSRGLGFSVIDYQDPMHRGESVIVIRSLVPGGIAQADGRIVPGDRLLFVNATDLSNASLEQAVNVLKSTPAGLVRLGIAKPVPVDQVRKDNKTANKMFYLVLVQNKITTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1F2</accession>
    <name>A0A914Z1F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GST C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1F2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g595.t1">
        <property type="protein sequence ID" value="PSU_v2.g595.t1"/>
        <property type="gene ID" value="PSU_v2.g595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g595.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12397" checksum="5E649D95623F995B" modified="2023-02-22" version="1">MDIRPFFMVYMERAEGDKDDLYKNTYLPAAEKVYGRIGEILSKSTSGFLANSGLTWGDFLLSENTLTLQTMDPEFSTRFPYMVEHQKKVYAVPQLQEYLKNRKPSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Q8</accession>
    <name>A0A914Z1Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease-reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Q8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5830.t1">
        <property type="protein sequence ID" value="PSU_v2.g5830.t1"/>
        <property type="gene ID" value="PSU_v2.g5830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5830.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="13098" checksum="CE6A5CE9BBA20CCA" modified="2023-02-22" version="1">MIYASETWALTKTEENRLAVAQRRMDWRMLNILLIDRHPRGWLRERTQFKDVVQLSHERKFKYLRKLMLLPNHRWNRILTEWVPNVNRPAGRPPTRWIDDFTKFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3Y2</accession>
    <name>A0A914Z3Y2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3Y2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6599.t1">
        <property type="protein sequence ID" value="PSU_v2.g6599.t1"/>
        <property type="gene ID" value="PSU_v2.g6599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000015">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1066"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1103"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="252"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="891"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6599.t1"/>
        </source>
    </evidence>
    <sequence length="1170" mass="131995" checksum="01FAC00C9B044CAA" modified="2023-02-22" version="1">MAIDSLVESVVTYNKRQPLLHLYGGPFLALYLIWFYFWIGIYGYEEFWEIGCIVTTCIGILQVLSVLFCYWFVSVNCLFTCNWVKDPKKAVWARVDPTPNNGWSELIPLRRTSLSDGTVRLWFNFQKVLYAYNEDKNTFSSVEFDTNKPFKYYKAYKGIETDQELKTTWMEYGNNNMEMKVPLFSELFIERATAPFFVFQVFCVGLWCLEDMWYYSLFTLMMLVTFEATIVKQQLKNMSEIHNMGNKPYPLNVYRNKKWVRINSNELVCGDIVSVVRSAEDRAVPCDLLLLRGQCIVDESMLTGESVPQMKENIEDADNDRYFEFSNDSRLHVIFGGTKIVQNTPVTKADGGMRPPDAGCLCYVLRTGFNTSQGSLLRTIMFGVKRVTANNLETFAFILFLLIFAIAASAYLWIKGSEDESRNKFKLFLECSLILTSVIPPELPIELSLAVNNSLIALQKLGVFCTEPFRIPFAGKVDICCFDKTGTLTTDALVVEGIAGMSGLTEEGEVDINKNSQEIATTTLQVLAACQSLAKFDEELVGDPLEKACLTWIDWNLTKSDTVIPKKGKASPLKIVHRFHFSSQLKRMTVIGGYTQPGISDARHLALVKGAPEVLRDMYEKLPEDYDKIFKKLALSGSRIIALGIRELGTLTHQELRENKREFYEQKLSFAGFVVIHCPLKPDTRNMIKEIIESSHRVTMITGDNPLTACHVASVLRFTKKRSRIMILDEPLEGEEPGWKSMDGSESAELVPRGKVAIRHFIGANELCLTGAGFEILSNEHPNFLKSIIADVRVFARMSPKQKERVVNLLKSLGYITLMCGDGTNDVGALKHSNVGVALLSHPYNANKPKVEENKEITETANASANANLPKQPVPLLVHRRGAPRQIDNRVSRHQASVTNAQERLEKMMKQLEEEEAVKVIKLGDASIAAPFTSKYTSIQSICHIIKQGRCTLVTTLQMFKILALNALVLAYSQSVLYLDGVKFSDTQATIQGLLLAACFLFVSRSRPLKVLSRERPTPNIFNAYTLLTVTLQFLIHFLCLIYVVQESHRLVPREKVDLQAEFAPNLLNTAVYVMSMALQVATFAVNYRGRPFMESLFENKPMLYSVIGSGIGVFLLACNAMPEVNEKFQLVELPEDFRHKLVGCVVGDFVAAYIVDRTLNFFLGDMRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4G0</accession>
    <name>A0A914Z4G0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z4G0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g724.t1">
        <property type="protein sequence ID" value="PSU_v2.g724.t1"/>
        <property type="gene ID" value="PSU_v2.g724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000006">
        <property type="entry name" value="Sensor histidine kinase WalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050351">
        <property type="entry name" value="BphY/WalK/GraS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42878:SF15">
        <property type="entry name" value="BACTERIOPHYTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42878">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g724.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13002" checksum="9508C8328E72E3C3" modified="2023-02-22" version="1">MIRQVWLNLLGNAVKYSGNREPAKIRVDYQQQPDGGHQFTVSDNGAGFDMAYAGKLFGVFQRLHKASDYPGTGIGLASVRRVLTRHGGRIWAEAEPDVGATFHFYLPPAVDADKQGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4R2</accession>
    <name>A0A914Z4R2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4R2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7344.t1">
        <property type="protein sequence ID" value="PSU_v2.g7344.t1"/>
        <property type="gene ID" value="PSU_v2.g7344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7344.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23769" checksum="028AF07BEF28EE9F" modified="2023-02-22" version="1">MSKPKIEKTQQKTTAATVEKEESEEEGENSKDEAKPPTETPSSQVSSPSVTLSSLHQCPSLPTAPATPTTTSSPLISVAGATPETTASSLPTTSPPFLPPPPPLTIISAENNEETPSNSKPILPFSKADENKKEEGSNDQMSSLKLFKNTPGKPKESIFETKHSNLYALDKDYLSKLIETKQKYERLLKSHMKCVPEDELKEREKSKCIFLGFIFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4T8</accession>
    <name>A0A914Z4T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4T8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6999.t1">
        <property type="protein sequence ID" value="PSU_v2.g6999.t1"/>
        <property type="gene ID" value="PSU_v2.g6999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6999.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12810" checksum="8C3EF1D1696D672D" modified="2023-02-22" version="1">MTRRKSKRSEHASATATESESDTSTMPMYKQAILRMCQFQIRICSKLIEIHCLKNPDEPETLKHAARRTILNENSQPLKVIDSLVDTLPRELLTFLRVGIPPWKVYLTTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z561</accession>
    <name>A0A914Z561_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z561"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7032.t1">
        <property type="protein sequence ID" value="PSU_v2.g7032.t1"/>
        <property type="gene ID" value="PSU_v2.g7032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7032.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33588" checksum="D19EDFBFA06EE315" modified="2023-02-22" version="1">MSGSKGLDWYNETEIDKMHMLAACSEGNIELVKEFIERGVNVEEFDDDGVTALQIAAARGHTKLTEFLLSQDADLEFCNVVGYTPLLHACREGHIEVVKLLIQRGAKLDVTTFTGASPLTLACAGGHFELVKYLLTFKDMVDINPKSTMISPSPLMAAALKNQPVIASCLVSRGARTDYVMPNYSLDIISCVVMCSTATMFSTLLDLGARIEGIRNYKNSNIDDLVNLCQKHDMWRVLVDHKRQHKRLTQKSLDIRQVILEGHVVELADLLRHPEKWTKLDGGETPLMYAVIFGQIECVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6X9</accession>
    <name>A0A914Z6X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6X9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6003.t1">
        <property type="protein sequence ID" value="PSU_v2.g6003.t1"/>
        <property type="gene ID" value="PSU_v2.g6003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6003.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17662" checksum="C8F7643A7ACB1239" modified="2023-02-22" version="1">MATTTTVTRRTVTTAGTTTSSTTVIPLWTIKLICAVLSVVVLILIFIQKAHVWQGFASTFIFITLTCGFILGWSIQAVLTRFLAFYRVDVVLHSIIVTLTVISTILCVLFLFNQRDYSRSDTYSYMVGITVCMSISMLITFLLIGCLWRGNYAIVDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z770</accession>
    <name>A0A914Z770_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="3 8">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z770"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7752.t1">
        <property type="protein sequence ID" value="PSU_v2.g7752.t1"/>
        <property type="gene ID" value="PSU_v2.g7752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7752.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32373" checksum="08365ABDA39DD0E0" modified="2023-02-22" version="1">MTSAAGAAIELKEISSAKCFGGLQKVYEFYSNELKSNTKFGAYIPEGAQNKKLPALFYLSGLTCTEANFIEKSGFQRYAAEHKIIVINPDTSPRGVKIEGDDESYDFGTGAGFYLDATVTKWSENYRMYSYIVKELTGIVFSQLPVDQKRVGIFGHSMGGSGALSIGLKHPEIFRSISAFAPICNPMNCQWGQKAFTGYLADDQSKWKEYDATEIAKKYDGPEREILLDQGTADKFYHEKQLLPENFVEVQNSKIKVHFEKREGYDHGYFFISTFLGEHFKFHSKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7D6</accession>
    <name>A0A914Z7D6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7D6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6158.t1">
        <property type="protein sequence ID" value="PSU_v2.g6158.t1"/>
        <property type="gene ID" value="PSU_v2.g6158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="17"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6158.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39190" checksum="45AD1E49A7FD02F3" modified="2023-02-22" version="1">MAVQSGSLSQQYFNVIAAVTCYWICSISLVFLNKYLLSSPDLKLDAPFFVTWFQCLCTVLLCFFCGWLSKYFPNYIQFPSMKVDHRLSREVLPLSFVFVGMIAFNNLCLKNVGVSFYYVGRSLTTVFNVICSYIILGQQTSKKAMLCCAFIIFGFFLGVDQEDVAGSLSVSGIVYGVLASLCVALNAIYTRRTLSVVGDSIWRLTLYNNINACFLFLPLMLFSGEIGNVAYFTGIMSPYFWTMMGISGFFGFIMGYVTGWQIQATSPLTHNISGTAKAAAQTVMAVGYWQEYKPMLWWASNAIVLIGSGGYTKVQQDEMKRKHNENSRLPSQREERDVLLSESHAEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7R7</accession>
    <name>A0A914Z7R7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7R7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7940.t1">
        <property type="protein sequence ID" value="PSU_v2.g7940.t1"/>
        <property type="gene ID" value="PSU_v2.g7940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF322">
        <property type="entry name" value="HELICASE MOV-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="55"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7940.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29678" checksum="4391DB7B4493D240" modified="2023-02-22" version="1">MPLFTFGNVNTKFAIAGDPKQLDPVIVSSVLRYKSYNSKLSTISRLNDHPEYEEFRKNKRNFVTLNTNYRSQTEICTLVSNIIYENKLISSDPSDCNDFIGCEILKNKEIPIVFWDVNGAEKSVNTSFMNQEEIDQVFQTIENIFKLHEIYISQSDIGVVTPYKANVFGFKKRLEAVYPEITVDSVERYQGSERDVIIISTVRTKKLGFLCDPKRLCTAISRPRKLLVLIGCVPVLIKDPKWKELIEFLHKNNCIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7U0</accession>
    <name>A0A914Z7U0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7U0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7934.t1">
        <property type="protein sequence ID" value="PSU_v2.g7934.t1"/>
        <property type="gene ID" value="PSU_v2.g7934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7934.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20078" checksum="4A13AFC09FC1A00B" modified="2023-02-22" version="1">MLQGPTPTDPTQPKLYFIILPPPPVNNQTTLSQTNNGGGGSKMSNKVRKAHSSSNSSDMINQKVIKQEIMEPSTDSAEFNVTALSSLRGNEIPSSSHANNEYGILQNSSGFKEGQISSGFISQRVIKQEIMEPSTDESNFKAPPRVQGLPSYPHNSAEMLNNDQEVGITSNTDLILSRCLQLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8E2</accession>
    <name>A0A914Z8E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8E2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8121.t1">
        <property type="protein sequence ID" value="PSU_v2.g8121.t1"/>
        <property type="gene ID" value="PSU_v2.g8121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8121.t1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42665" checksum="5DBCB0DE14A0ED0D" modified="2023-02-22" version="1">MRTKDRIGDMEVNLFLLPSAVNDGTSRIAEILKIDEKMAEFEAKFAEEASKFSSQNQGAAKLELMRRKKRQELFAEAEKTKSTDSDAEILWKINFNILDRIYRDRLLLEILINDVGIDDIGEKIMRAAFGFCLKLQDGNASQPCAKFFSRKDLEVVLRDNADITADDYEATLYLVSSSADRFIRKVGEGSGGLYTIDYVDGMRMLLTKDTSYEFNPMSSQFLYGVDLLKVNLNQFQKVLQYQSNYINRRLKEKEEIIAVKSVKNKVRKMIDYAKQNITDDSELADTIEDVSNEFDQGKRMKLRRYRQFRDYLKKVEMMLNETIWILHRNCEMEQRKRKEEGGNDIKRSKKRAADAQNSGLEAKRARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9X0</accession>
    <name>A0A914Z9X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9X0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8592.t1">
        <property type="protein sequence ID" value="PSU_v2.g8592.t1"/>
        <property type="gene ID" value="PSU_v2.g8592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8592.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="24326" checksum="DA66DAE82F788748" modified="2023-02-22" version="1">MYFVQREIIDLARPTGIEEEFSANSTVEITTEKLLETTLESRVTATNGPSTPTIIPTTAAPIVGIKEIQNIRNIPETIANETTPSESTSSSTTTSATTISLEPLKKVTELRKEVVENVEVLTSESPLRAKIVVIPKEILATTDASEISENITDLGASTKYSEILEATTNSPAKKSSSTASESLIPKKSSTEEISVSSEEQKSGTSVTAAAASIPSLRLILRRIFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA17</accession>
    <name>A0A914ZA17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA17"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8631.t1">
        <property type="protein sequence ID" value="PSU_v2.g8631.t1"/>
        <property type="gene ID" value="PSU_v2.g8631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF91">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8631.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12350" checksum="3AFBBCE3BD078406" modified="2023-02-22" version="1">MPFLALICMILIALLFIPNPICTFWITIAIITIDLGVIGFLSLWDVKLDPISMITLILAIGFSIEFSAHVTYGFVSNPGNLTPKERCIDSMEKLAWPVFVKNFEIFITLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBP6</accession>
    <name>A0A914ZBP6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Caveolin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Caveola</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the caveolin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBP6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7673.t1">
        <property type="protein sequence ID" value="PSU_v2.g7673.t1"/>
        <property type="gene ID" value="PSU_v2.g7673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070836">
        <property type="term" value="P:caveola assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF21">
        <property type="entry name" value="CAVEOLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7673.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26469" checksum="4152A921AAAD5950" modified="2023-02-22" version="1">MSEKVELAEQIPLKTDTDANEHIVAEGGDVEVGQVVPEKAVTEKKKFFSWKKNKQGEVVSEKMTSEVKETVENGKKKCWWNCQKAEKADKTEPTFGMDINRDEKSLHTAIDLEFSDIFGEPEALHSFQPFWRWTNTIFNGVRNFFYKLITVIFALPLAIVFGILFAVVSALNVFVCVPVGRLLQIPAGWIFKTWNFVISNVFDPITRSLGLLFSNISMRRYGINNEVTQPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC65</accession>
    <name>A0A914ZC65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9512.t1">
        <property type="protein sequence ID" value="PSU_v2.g9512.t1"/>
        <property type="gene ID" value="PSU_v2.g9512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9512.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10041" checksum="DD28CB27271AF127" modified="2023-02-22" version="1">MAFFDSTNSKISLKIDESELLGIRKMIAEIKDLMNNTVSSTPAYDSVEELASNLEKQNNLAKIKDSLNDSISSSSSGYASAEDLSDSICSTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCV3</accession>
    <name>A0A914ZCV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g809.t1">
        <property type="protein sequence ID" value="PSU_v2.g809.t1"/>
        <property type="gene ID" value="PSU_v2.g809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="317"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g809.t1"/>
        </source>
    </evidence>
    <sequence length="648" mass="72581" checksum="AFBD5395E9E324E5" modified="2023-02-22" version="1">MAAVRFYPIPASFDATFWNELNRLKLDEWKLEDKEQPIHANLPFVAEANLAYTFSMDYSSFKVAEEDQADNVKGILYLYNTIEHFNDQTRRKEHMNQHGQKLWDLIRDGSWTKNPRELLRFIIFMFADLKEFYYRFHTGVPTLSFPKDGLKVGDCAMRSDIQQELSKFQFSSFDSFPKLFSFTNGKAAIYDFDQLPNLNNEETWVITSVIDPKNTDVLHWEIRNLITAIAFHPVKWTSIKVAAIRPDCSISTSKVFSWDSSVLDEKNFTVVGLGNNIPLTFNLKSFFSKDELISQAADLNVKLVRWRMVPDLNLEKFKCKVLMLGSGTLGCNLARGILGWGMRNITFVDCGDVSMSNPVRQSLFDASDIGKPKAEAAAQSLKRIFPNAQVTALSMKIPMPGHPAGNDFEKVMAAVKQLEELIKSHDVIFLATDSRESRWLPTLLATAYSKLAFTVALGFDTFVVMRHGIGPNSEMHQSNFHKDLEISGKDLGCYFCLDVTAPGNSISDRTIDQQCTISRSGLSQIACGIAVELLASILQHSQGAEASAKLVGVNENSGTLGATPHQVRGHISAFNLNTATTQRSSICCGCSLKVCNKLSNENEWKEFIRGVLDDPRYLEKVCGLLELQEAANMIEDSIIPMSDSDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD40</accession>
    <name>A0A914ZD40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZD40"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9860.t1">
        <property type="protein sequence ID" value="PSU_v2.g9860.t1"/>
        <property type="gene ID" value="PSU_v2.g9860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9860.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12119" checksum="FD2857A0FC1C8C03" modified="2023-02-22" version="1">MSKVVGKLNNLNYLNFNDCLCRSIGSLNIVQELVKANSSVQELLLSGNEIDAITMKKIIEMSVKLSSLNKFMLSCNSLGSMFDTLKRQHTNGIIDLGDESDDEGSASETEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD54</accession>
    <name>A0A914ZD54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enoyl reductase (ER) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZD54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9874.t1">
        <property type="protein sequence ID" value="PSU_v2.g9874.t1"/>
        <property type="gene ID" value="PSU_v2.g9874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000147">
        <property type="entry name" value="Reticulon-4-interacting protein 1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9874.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28486" checksum="EA295E42ABE88561" modified="2023-02-22" version="1">MNPIDCRMTEGYGDQILSTWKQLDSFSLQRQSRLPLIAGRDCCGEVIAVGGNVTGVNVGDEVIAVIPGFWPGSHAEYVLTRSDAVARKPANVNYLEATSLPYVACTSWAALVSVAQINPNNASGIRVLIHGGSGGIGSAAIQMLRAWGAEKVVATCSKNNMGYVSSLGGIAVDYNSQDVKDQLISEGPFDVILDCVDTDLARWSDKVMGVWRNCVHVSLVSPMLRDTDRYGKLLIIIIIANSNRITFICYSFFLFLHCFQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDX5</accession>
    <name>A0A914ZDX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDX5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8479.t1">
        <property type="protein sequence ID" value="PSU_v2.g8479.t1"/>
        <property type="gene ID" value="PSU_v2.g8479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8479.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34986" checksum="8D44E4B3DCDF261B" modified="2023-02-22" version="1">MNNKILCVGFCTIDVINYVNEEKLEDCKIDIIDERKCIGGNATNTANVLKQLGVDVDLCAVLANNDPEIEELLAGIKLKTDTCFYRHGTFPFSTIVVNEANGTRTIFHHSRNLPEIQAKDFETKFAETLGNYSWVHLEGRNYKNVEKIIKFIDNFKKANNRGDITVSIQFEFTPTTPCSEDLFKLANILFISKEFVIAKGWETAIEALNEMKERFEGLKNTTIICAWGKEGAYGIEPNSKKIEWTIGSPVKAVDTLGAGDCFIAGIIWAMNQKLNLLKCLQIGVFVESGKCEQIGVSNLNHLRKIKKFVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHP1</accession>
    <name>A0A914ZHP1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZHP1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9821.t1">
        <property type="protein sequence ID" value="PSU_v2.g9821.t1"/>
        <property type="gene ID" value="PSU_v2.g9821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9821.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="10235" checksum="B658FBDD9BF4D541" modified="2023-02-22" version="1">MIVTNLRDTYLNGTLKAYALLQWQQHFCPKIKYLLKADDDVVADIPRLQYWIKKDFYGISKKHNFNTIFCKVIKNGTPLRNSNKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS62</accession>
    <name>A0A914XS62_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10824.t1">
        <property type="protein sequence ID" value="PSU_v2.g10824.t1"/>
        <property type="gene ID" value="PSU_v2.g10824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="9">
        <location>
            <begin position="300"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="457"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1470"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1470"/>
            <end position="1481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10824.t1"/>
        </source>
    </evidence>
    <sequence length="1516" mass="173200" checksum="373AE302339ABFAC" modified="2023-02-22" version="1">MSTNAQNIWPPPAFNGTVRFETWELQLDMYMSSRKITDDGEKALALLQYIGMEMLEKIMDWCYPNKPNTFSYVDLVKLVKSQCSAGPNLFARRVRLFNEKQQSDQSVQEYFSHMRQLLGQCEMKNMTPQEYGVLAALRGLRSDELRQFLMSPANDISDMEKAQALAVSYDQSRLAARDIKPKEDKFKPLSMNVVGKGYKCGYCGGTHPKGKDRCPAKGATCNKCKRKDHFAKACRSKVENSDGQKSKGNFSKRQNLVEEEDEAEVINMNGLYGVLKLTTDPNLEIPPPIMIKAKLNGSFVNFQHDSGAATTVINEGTWKRIGSPELQATKIKLRGYNSIIQVLGICEVTVEVEDKRKILWVIIVKEGEALLGRNWIRALKLRAEEELYESCNQVEAVDRLKLILEKHEEVFKDELGTCKEKVSLKLIDNAKPAFIKARNIPYAYRGPISEQLKKRVETGVMKKVQHSDWGTPAVIVKKSNNDLRICGNYKLTLNPQLDVDQHPLPRTEDVFHELNGCKVFSKLDLKDAYHQLELDEESQKLTTITTHEGLFQYRRLPFGVASAVAMFQEKMEKILQGIPGVIKFLDDVEIGGSTIEENLDRVDQVLQRLKDYGMRLKREKCEFLKSKIEFLGHEIDGTGIRPSPTKLNGFKNMPAPENVKQLEAFIGFVNYYGRFVKDFSTLAAPLNDLRKKEAKWIWDGRHQQAFDEIKARLLKGDLLTHYDPSKKLVLATDASEYGIGAVIYHRETDGTEKVISNASRKLTSAERNYAQIEKEALGIIFGVKKFATYLLGRHFLLLTDHQPLLKIFGPKAGENSIAIKRLARWAIILMNYDYSIEYRKTGDFANADGLSRLPDPSEDPSAEMLDGEDDFEKLFAIDEAKSPLNLDSIMEATLEDKTLQQIMNYVKNGWPNSAEKDLKSWWSRKEDLSCRRGYLLFKDRPVIPKKLQLEVLKILHEAHVGRNRMLLLAKDNFWFPKLNDAITQIAKSCEICNGDFKGQKERLHAWEEAAEFWDRVHIDHAQFRGKLWLIVVDSKTNWIEVLPAVSTDTKTTIKLLKSLFSRYGLCKILVSDNGTGFTSGDFEEFCKSRGIVHTKSPPFHPQSNGVAERAVRTFKEFTEKHIKAGHSLEEAVANALLIHRSTRGVSDKLSPAEAAFGRKLRTRMTIHQVHLLMQGEEKVEDFDVQDKVWVRCYSAGPRWRPGYIRSVKSKCTFIVECGGELLFRHRDQLRKACESIFGKSGKAVEEMQQGKKDCTHTGATSDESRNVCPPNVVAEKRKKEKQNLQPTRASSRIRKTNQKYSSNLYINCLKMDRVRPYSGGGGRAEFIGRAIQTNSDEAKIRAKMKCNKVDLVDIGRIIDKFMNKKEEAELEKIPIALKMAEDIAEGKVADAKDVEEFQMIKAKVKKFEVDIAKYKEERSEISHDGFLLREELKDLLSDERRRQAIKRRVGQLHSADVKLKGYRVARERYQDGKMDPKDYRTRPPISYSARPRISYESSSEAEIDKENHKNYSRKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XST4</accession>
    <name>A0A914XST4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XST4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10334.t1">
        <property type="protein sequence ID" value="PSU_v2.g10334.t1"/>
        <property type="gene ID" value="PSU_v2.g10334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052854">
        <property type="entry name" value="Serpentine_rcpt_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47518">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS EPSILON-13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47518:SF9">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10334.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27209" checksum="6C05DBB92A31A06B" modified="2023-02-22" version="1">MRHNRLIGICIALQWGFASLGVYCFCTGIVRSSILIAIYGLIMFVSVLIYVLLSWINNRRFRLYQQNRKSLCLSERFQLSENLRTQKMFANLTIVLFVANILCLGAFVFMSYGNGNFLQPCLKAIFDYSVVLYAYIFPIISITSVPDLRISYSMWFYRCRKRIFPISATNGDEIDDTRKKLKHLKNTKGKQMVFTIEQEMAVYYTTLNAIWSEDIRHDRHRVRYTPDKYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT46</accession>
    <name>A0A914XT46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT46"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10444.t1">
        <property type="protein sequence ID" value="PSU_v2.g10444.t1"/>
        <property type="gene ID" value="PSU_v2.g10444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10444.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16289" checksum="26951890223A80DD" modified="2023-02-22" version="1">MVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYRKYIEKALHWRRRFQKVFVGEPSVEDTIAILRGLKESMRCTTGWRSPTGHRRRCDAVQPLHHRPPVAGQGHRPDGRGGLAPAHGDRLQARGTGPPGTPGDPTEDPARDAEEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWM4</accession>
    <name>A0A914XWM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWM4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10167.t1">
        <property type="protein sequence ID" value="PSU_v2.g10167.t1"/>
        <property type="gene ID" value="PSU_v2.g10167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10167.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34987" checksum="EFBB400CC0307943" modified="2023-02-22" version="1">MDAQTSPSFAAGAKPKFINGKIVWAGGPSIKQHFALPEPIMYYIAKNPSTPEVYKKLVRSCKYFFEKMQILVVGNLYGNTKICLNEDCDGDERKEKCCFDIDFNKFSNKIWVTNNVCLDEENISTFSSLIFPKLFRWNNIQLHGFADNIMFDDFKKVASFLTDISFVGCRIINDDGNVVMLDKIFEITTNIKDFEFCFFNDFSMINAATMKNICKLKNLQNLEAFRLLFIPEIFNVEDLSNFIKNHQNTKICFSFNDGISEEYKVQVDALIDTVIESEVPNRLINYAGQNQEKEKIMKDCYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWS5</accession>
    <name>A0A914XWS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWS5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11416.t1">
        <property type="protein sequence ID" value="PSU_v2.g11416.t1"/>
        <property type="gene ID" value="PSU_v2.g11416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF15">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11416.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18380" checksum="B0819D37266422B1" modified="2023-02-22" version="1">MTRCHLCRHSHLCRQHRRYKLVHRDTLKPSRMCFESIFSWNNETVNIWSHFFGFIYFTWVQIHNIFFVLPGIGANSNDYIMMFLSVFGSQLCMASSAGYHTFGCINSRTRKTWLRADVFGISAGLLGMYLGGIYTSFYCFPDIQNTYLLGLLHEKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXL2</accession>
    <name>A0A914XXL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXL2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12689.t1">
        <property type="protein sequence ID" value="PSU_v2.g12689.t1"/>
        <property type="gene ID" value="PSU_v2.g12689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12689.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24176" checksum="46DD0B91BFEA5A95" modified="2023-02-22" version="1">MSFVDNYGGIHAREWTAIHTSVYTIFNLANGILQNDTKLMKILENIEIVVFPVLNPDGYEYTRSDPRNALVRMWRKSRSHERCATNRNGEKSCCRGTDLNRNFAYKFAETGTSYHPCSEIYHGAGAFSEPESRNVRDAIINSEFTGRIDAYITLHAYSQLFIYPYSNRKRHYPQDVAQLKKVAQKAVSAISRLFGTHYLIGTGPEIIYIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXN2</accession>
    <name>A0A914XXN2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase delta catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXN2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12707.t1">
        <property type="protein sequence ID" value="PSU_v2.g12707.t1"/>
        <property type="gene ID" value="PSU_v2.g12707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="2">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12707.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20864" checksum="95663DBC5881CDFF" modified="2023-02-22" version="1">MVDPDIITGYNIQNFDLPYIVDRSRHLKVDANVHLLGRVKNSACRIRDAQVQSKQMGNRVNKLIVIEGRIIFDVLQVILRDYKLRSYTLNSVSYHFLSEQKEDVEHKIITELQNGSDLDRRRLAVYCMKDAYLPLRLLDKLMSVINYMEMARVTGVPLNFLIFRGQQVKVLSQLLRKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXX8</accession>
    <name>A0A914XXX8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="15">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXX8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10580.t1">
        <property type="protein sequence ID" value="PSU_v2.g10580.t1"/>
        <property type="gene ID" value="PSU_v2.g10580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000554">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10580.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20551" checksum="92C402288106EEC9" modified="2023-02-22" version="1">MGLTISSLFGRLFGKKQVRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRYYFQNTQGLIFVVDSNDRERIDEAREELTRMLAEDELRDAVLLVFANKQDLPNAMNAAEVTDKLGLHTLRNRNWYIQATCATSGDGLYEGLDWLSNQLKNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXZ0</accession>
    <name>A0A914XXZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10590.t1">
        <property type="protein sequence ID" value="PSU_v2.g10590.t1"/>
        <property type="gene ID" value="PSU_v2.g10590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF45">
        <property type="entry name" value="SUPERVILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HP" evidence="2">
        <location>
            <begin position="894"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10590.t1"/>
        </source>
    </evidence>
    <sequence length="957" mass="109879" checksum="3FA6A5A4A51804C4" modified="2023-02-22" version="1">MLAERRSALFANQEKWKEKIGNQTRRTSDVTISKLSSIEARKNALLQASGEWKSRVQNDESINSLNAAYRFQQSQILTPKTPISSRQHPTEPKSVPRHTKFFPVVENNKVKELANTTILIRAKEESKDQRNDNDMEKGDAESGGIQRETSLINGIRRTTARPQRRPPSTMAPLSIDTSSATPTVVSMKRSPASDKENGDDGLKEPPAKQPFSPQISEDRTPKLGVKNCGIALKKPDLKRPYHDVMLIRCKGTKHVDVRLVAPCASSVHDCATFVLVTSSRLFIFEGEFSFLVEKAKAKQIAHSVVASRDLSCSASKFEHVKDDSRAERAFWEFLGDKDQSRRIPEELERFMDSENEEDLFEDSVKIANTIYEMDSDGNGTIVSKGDIPHSSILDSSKIFVFDFGTEIYIWLGHDSDRIGSKRAMEFAEKLQKTPIIYSEIVASFPENNGERPEWILIRKFTEGLPDCLFRLKFIDPLPEPTAKTPKTLKFTTERFIYAQKKTGRIAPLPLCGVENLLKDEDVLIENLAERLVNEEPHVNVLELEETELRPEDENIFTEGLLYYQLNGEVLEELEELNEFLDRECYVIKWLYRVERSGIRKLDGTPVPQKDTGRQRVAYFYWFGKLATKKSRGSLALALRRLDKDRREHVLMEQGSQGHLFLNLFDGKMIISSSDLAASSSNNCDKRVYIIHGSTDTYFYAEEIDDLDDLQLRIQTSYIFVNSLTKIVSQWNGKLATKQIIKGTNQIAEKIAHLHNYSLSSSSSINYPTTEPYEWRHAPRIFRLFDTEAEQLHSLQFAKTVNFTFRQSDLRDTLLVDQGSCLWIWTEVLVTTFHLQVASKYWKSKNRTNKPATVICKGNEPNEFKALFPSWTKWSAFNFNEVYAEHPQELAVLLDERTKFRSLEEVRDRKLPNGCDTKRLEKFLNDEDFSKVFKMERDAFYSLPKWKQTTLKKEANLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY14</accession>
    <name>A0A914XY14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11847.t1">
        <property type="protein sequence ID" value="PSU_v2.g11847.t1"/>
        <property type="gene ID" value="PSU_v2.g11847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11847.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18373" checksum="B2C0AEA793233CCF" modified="2023-02-22" version="1">MFLMIFIDLEKALSNFTDSTSGDFWIGANDLVMSGNWSWTDKTSFDFTDWDKGQPQNVSDCGAVIMAHGKWITDDCIKQKAFICLVSSISTTPAASTLPVTTTMKSTSCPPSWTYYSTTGFCYMSFPNGTWLYGEDRCRVENAHLASVHSHEEALFLAGTVHTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y062</accession>
    <name>A0A914Y062_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y062"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11264.t1">
        <property type="protein sequence ID" value="PSU_v2.g11264.t1"/>
        <property type="gene ID" value="PSU_v2.g11264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11264.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22753" checksum="CF5FD16ADC936BE0" modified="2023-02-22" version="1">MFRVLVGFSTLALLIEIIHYHINEILILLLDCGADDWRVVLTWNRIAQFIVEFIVCSICPLPWTGTTDWIFIEPSRFNEHVYTVKKVPIDVLLSLLMLGRVYLFARFSVLHSKQFQDASTRTLAALNRIQVNFSFVMKTVLDQRPVLFLTVFTLIFWITTAWTFAQCERIGREEEPPILYSNALWFIGKYTTVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y090</accession>
    <name>A0A914Y090_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y090"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11290.t1">
        <property type="protein sequence ID" value="PSU_v2.g11290.t1"/>
        <property type="gene ID" value="PSU_v2.g11290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF17">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11290.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20331" checksum="B312F716E28F199E" modified="2023-02-22" version="1">MRGIAFGADFAAIGVVCSRWASLKQNGIFISILTLFSSLSSAITNPSAGALCESSWGWPSVYYIHGIIGCILFSLWLILYTDHPATHRNVSSVELEKIHRNKTAAHIKMDSYIPYWAIITNPVVLVVWLNALADIGSGIFLLTYTPTYINAVLHYNVGKTGAMGALLALSHIPFKLVTGYLSDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0D4</accession>
    <name>A0A914Y0D4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SAND domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0D4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12927.t1">
        <property type="protein sequence ID" value="PSU_v2.g12927.t1"/>
        <property type="gene ID" value="PSU_v2.g12927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059099">
        <property type="entry name" value="GMEB1/2/Spe-44_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000770">
        <property type="entry name" value="SAND_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417">
        <property type="entry name" value="GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417:SF4">
        <property type="entry name" value="SAND DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25892">
        <property type="entry name" value="Spe-44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00258">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAND" evidence="8">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12927.t1"/>
        </source>
    </evidence>
    <sequence length="495" mass="54483" checksum="BF73479300F04AAF" modified="2023-02-22" version="1">MNENDSSTPSLLLDPASTAAAAIAHLQSQLNVQNNISTTANGTQINFDDSSSIYPAVTPESIGDADSGVETKSIDIKSESDHCMMNQDPDSGDDLPPMEPAANARILDVRCGNLTGKLYEERFTCPGIHKKCIEFDGRLVSPREFTIRAEKDKQKDWKGSIRVGRYNLRTLMEMKKIDFYDHESNCSLKCQSRNYIKNRKQAAIESSMNFLDTLVKNGATITSAASDLSGVDQQPSSSASTFNDFNISGTNDENGFNGSRKGSSALEEYVSRMSTSSTSSTATLAKMVIKNEQHLEQEPRKQSTPQPHHIQPQTPQTLPAFTPDPNTVANLLWKQLNGQLPPAFQGIFKQQQQAPPPPAPPIIPQENDQVTALVNSLLEQQKGLLQNQFNNSGLMGNNSFNTSGNGGAATTEDILRSGEALNGNALKRIMEQQPTMFWERMRELNLVDDLASHISAAVDQLKSIYRSADPRTDAFGMFQLFNSAFLTFIKAFEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1B8</accession>
    <name>A0A914Y1B8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y1B8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13014.t1">
        <property type="protein sequence ID" value="PSU_v2.g13014.t1"/>
        <property type="gene ID" value="PSU_v2.g13014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13014.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18842" checksum="0CB2FB1E5AABF14D" modified="2023-02-22" version="1">MTFRISSKSGRVEAEKAVNTWAGQCQSKIVEKLLKGYDRCFIMLEDIVSGYRKPCVIDLKMGTRQHGDDSSAQKRLTQMQKCRQSTSETLGVRMVGMQVYDRETKSYSFVNKYEGRRMDRIKLCSSLEIFFASAGINRTKRLITKLRELKIVLSQAEGFRYALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2A3</accession>
    <name>A0A914Y2A3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2A3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13368.t1">
        <property type="protein sequence ID" value="PSU_v2.g13368.t1"/>
        <property type="gene ID" value="PSU_v2.g13368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13368.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20729" checksum="9FFE0B3B768B156D" modified="2023-02-22" version="1">MLIGVNVNLKLDETVLQVYVYKSEVKTIELKRTDFGYEVVEKRTIVIKDGYSKEEIKTKIMDQSNPKQIIATLVECGGNNVMKDIRAALKSKKLAVLGTHVNGFTYETSLEILKHLYDENENKFHVRTPYSDIFGITDFVEVASHDDIILSTEGQKHLPFTETKVVTRFTKMFYVSFNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2D1</accession>
    <name>A0A914Y2D1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2D1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13396.t1">
        <property type="protein sequence ID" value="PSU_v2.g13396.t1"/>
        <property type="gene ID" value="PSU_v2.g13396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="166"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13396.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40802" checksum="E470955A2CA57623" modified="2023-02-22" version="1">MFAKKLRYKVDPGQELYALGLSSSLSAFFPIYPVSCSLGRTLVNVEAGTKTQLSTIASTIFLAAIIGYIGKWLETLPMCVLSAIVIVALKGMVKKFGDLPHLWPVSKIDCSIWVVSFVATVAWDVTPGLGISIIWALMTTVFRTQFPRWHFLATLTGTNDFRDSERYKAVVDHNGICIFRFDSPLLFTNVEKFKISIEHAVYKWETEKPALTPESILPEELKISPNEAEEIASNVVTIRSATDIINPDKPFASLFYRHFVIDCSGFTFVDYMGVNALKEVFTEMRSKKVLVYFASAKAPVRDLFEACGFYKYVAKHNFYPTIRDAVAIARKRRNASTMQLLDEIRLHHDILNDLIRTQPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y429</accession>
    <name>A0A914Y429_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y429"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12503.t1">
        <property type="protein sequence ID" value="PSU_v2.g12503.t1"/>
        <property type="gene ID" value="PSU_v2.g12503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12503.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10359" checksum="0094BC1278FE13AD" modified="2023-02-22" version="1">MRNDTERLASFGIRINNVNPGPTKTGIFTHDGSNEAEKNAGLSVYEKLSRNAVIPGGAEPWEISRVILFLADEQSKSITGASYYIDRGLSTFAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y466</accession>
    <name>A0A914Y466_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y466"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14022.t1">
        <property type="protein sequence ID" value="PSU_v2.g14022.t1"/>
        <property type="gene ID" value="PSU_v2.g14022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14022.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9428" checksum="1856FF5343563D1F" modified="2023-02-22" version="1">MPTDDGEKENSFEKNEKNIGSSFTQKEIKLFKEQWAKQLKYLNEKINVEKVEPDIGETIQEYTILAKIGAGGFGKVFSRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y505</accession>
    <name>A0A914Y505_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y505"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15282.t1">
        <property type="protein sequence ID" value="PSU_v2.g15282.t1"/>
        <property type="gene ID" value="PSU_v2.g15282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15282.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16422" checksum="B57306FE8C1ECE4A" modified="2023-02-22" version="1">MEHIQHLIDCEESYIDDIIEANFVQLFISLQDDGNIDLEVHRNALEFLSNILKFGNFDHALILFEDHFIISIRDLLNHDDSGVKEMTLHCIKNLLEKLSSDYANDARQEIINCGLLVKIKQLQMSPKLCKAANEVMAVFLHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5P7</accession>
    <name>A0A914Y5P7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5P7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14760.t1">
        <property type="protein sequence ID" value="PSU_v2.g14760.t1"/>
        <property type="gene ID" value="PSU_v2.g14760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14760.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36624" checksum="25DD3E21037224C9" modified="2023-02-22" version="1">MKWWGNIVATKESISSSYLFLAVFLIIFVFASITLIFLLTNFHESSKPSEIFSENHSNIEDKILSSKKYIEQIVTFGGFSCRGHSNIVISENYRCDGVADCHDGSDEVGCQECKTSFSCPYSNGSINKLCLRSHQLCNNNVQCYDSSDETFCQAQCSTNMCSDSSMCFPQSFVCDGEFHCPFGDDEKGCKGECKNESKWCKALNKCLPKWQLCDGIKDCQDGTDEEECDIRQCSGSEKYLCRIPDENKGYCIKRIQICNGISDCPNNLDEKDCFGMPKYGNTRTVKCNDGNFYSKIYACSGMIPACNGICDECDKQLSFDCGKIIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y761</accession>
    <name>A0A914Y761_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y761"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16045.t1">
        <property type="protein sequence ID" value="PSU_v2.g16045.t1"/>
        <property type="gene ID" value="PSU_v2.g16045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16045.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12348" checksum="26B9903722C4B0B6" modified="2023-02-22" version="1">MAKHTFAGNIKCRDGSKILPQATLRIMEYDAGEDDQILIIPLHRGKENPYKTWWESVVYVYEEFDWIWNDGAEVYYQFWHVCFEGQQVEIAPEIDGNKDKEYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7A3</accession>
    <name>A0A914Y7A3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7A3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14622.t1">
        <property type="protein sequence ID" value="PSU_v2.g14622.t1"/>
        <property type="gene ID" value="PSU_v2.g14622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14622.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="25274" checksum="34FADC343842F3B3" modified="2023-02-22" version="1">MAARTGDPRSVGVGRKDEAWQTRGERLVRRTTEGTLAIGSSPGEVDPHLRCIRRTDGCRIAHVGTDGGVAAGHGVDVVAETDVRQQVGKIVAWTVDQVTGEDVLVGRLAGKWRPGARRIDQARHAQRAAAHVPLQRAISVVDLHAGVVAGNRMSPCPPFEAGGALGHVPAETRSAGGNPRGAAIAADEHQVGHALRRKADRAVLAQRRRVAADGLHPLACREEGKGACVDQNGDGRCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7B9</accession>
    <name>A0A914Y7B9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Na(+)/K(+)-exchanging ATPase</fullName>
            <ecNumber evidence="12">7.2.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.13" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y7B9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15352.t1">
        <property type="protein sequence ID" value="PSU_v2.g15352.t1"/>
        <property type="gene ID" value="PSU_v2.g15352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15352.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="46233" checksum="9C0FFA6707051300" modified="2023-02-22" version="1">MFAFGFKVDNSSLTGESEPQSRSPECTNENPLETRNLAFFSTNAVEGTAKGVVVNTGDRTVMGRIAHLASDIESGMTPIAREIEHFIHLITGVAVFLGVSFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHTWFDKHIETCDTTENYGGHGDARERGETENALLRVAALCNRAEFKPNQNETPILKRECTGDASEIALLKFAELSLGNVIDFRAKNPKTVEVPFNSTNKYQVSVHETADGNQAYLLVMKGAPERILDRCTTMLLNGKEVELDDKLRADFNTAYLELGGMGERVLGFCDFRLDPTQFHRGFVFDSEEVNFPVSGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKERTFMCFKEKFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7T1</accession>
    <name>A0A914Y7T1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone DnaK</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7T1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16261.t1">
        <property type="protein sequence ID" value="PSU_v2.g16261.t1"/>
        <property type="gene ID" value="PSU_v2.g16261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16261.t1"/>
        </source>
    </evidence>
    <sequence length="435" mass="46933" checksum="D746ACB4CBA348D6" modified="2023-02-22" version="1">MDGKTAKVIENAEGARTTPSIIAFTDGDERLAGQPAKRQAVTNPEGTLFAVKRLVGRRFDDPMVTKDKDLVPYKIVKGDNGDAWVEVEGKKYSPSQVSAMILQKMKETAEGYLGETVTQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGLDKSEAKTIAVYDLGGGTFDVSILEIGDGVFEVKSTNGDTFLGGEDFDMRLVEYLAAEFKKEQGIDLKNDKLALQRLKEAAEKAKIELSSAQQTEINLPFITADATGPKHLAIKLSRAKFESLVDDLVQRTIEPCKAALRDAGLKAGEISEVVLVGGMTRMPKIQEVVKAFFGKEPHKGVNPDEVVAMGAAIQAGVLQGDVKDVLLLDVTPLSLGIETLGGVFTRLIDRNTTIPTKKSQTFSTAEDNQSAVTIRVSQGEREMAADNKMLGQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7X7</accession>
    <name>A0A914Y7X7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7X7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14853.t1">
        <property type="protein sequence ID" value="PSU_v2.g14853.t1"/>
        <property type="gene ID" value="PSU_v2.g14853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14853.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21970" checksum="6F8B07133993E189" modified="2023-02-22" version="1">MADAADNKNVIVDDEPSNLCFHFEAEDKSFPITQQFIQLSGMLRDYIESIPTSSDNKLPVNDFPASSHEILIKLLNLSKENDAAAYEKALQLEHVETEVPSAIQQFCKDLSADECINAANYCAYLSNDFAKHYFVHAFASLVKDTPAPDIRNLTAAFGATPLDKDDIEAHEMEHEGQIWTAYSKIYEDAYGHPYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8F3</accession>
    <name>A0A914Y8F3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pao retrotransposon peptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8F3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13873.t1">
        <property type="protein sequence ID" value="PSU_v2.g13873.t1"/>
        <property type="gene ID" value="PSU_v2.g13873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13873.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18707" checksum="B040B21AC0FB4B2B" modified="2023-02-22" version="1">MNNQQFHKQQKLCVKWELIADRLFISLPKPLPTKHSYTTKREVVQQIARVFDPLGLLAPAILPAKIFAQKLWKDGYEWDERLSKADETTWSNILTEWNSECSFSRRIPSICEGTYELHCFVDASGAAYAAVAYLVNQQHPTNPAAILFSKNRLCPIKAQTIPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8I8</accession>
    <name>A0A914Y8I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8I8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16510.t1">
        <property type="protein sequence ID" value="PSU_v2.g16510.t1"/>
        <property type="gene ID" value="PSU_v2.g16510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16510.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="12927" checksum="50B91EF4A9085A60" modified="2023-02-22" version="1">MPGDRAGLLDRSGQARLVQVTGAGTALALAEIDGHGDTAVTRGLHGLDLAEADIDLQAAVLAAADLGLAGAQRAGAVEQLLGEVGQPFQPGQAVVADGHFRGDHVQCFILYGLGPASRRATFFEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9Q6</accession>
    <name>A0A914Y9Q6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9Q6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16167.t1">
        <property type="protein sequence ID" value="PSU_v2.g16167.t1"/>
        <property type="gene ID" value="PSU_v2.g16167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16167.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19061" checksum="C63411BBC3B7C895" modified="2023-02-22" version="1">MDDGSSSTIEINSQTMFSRAESSMALVTQYIKSLPIQDIIKILTPVKARLLSEDTVLHINTLNFSVDHVVLPLTVKEVLEILGPQWQRWIHNPDATSPPNSHYDLHEHIKVGALDHIDAPPTDFVKEFIEGLTKKQKHSLLLLIRDGLLTDESFLNVSTYTGPDRIQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9U3</accession>
    <name>A0A914Y9U3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase N-like N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9U3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16983.t1">
        <property type="protein sequence ID" value="PSU_v2.g16983.t1"/>
        <property type="gene ID" value="PSU_v2.g16983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16983.t1"/>
        </source>
    </evidence>
    <sequence length="597" mass="67665" checksum="AD29EAC667D63585" modified="2023-02-22" version="1">MNTKEENVFEGNVRILLELKAETDLIVLHAGRHVSDVAETRVNVFLCSNGEQICVQAVSRSLDQQLLLISLSKKISEGTFIVIEISYFETVIPNNKGLFIQKPTTWEAWLIASVFESTGAHEIFPCINEKSARSTFSLCLIVPTQLSARANMPVTMKTNMNDLYKICFEKTVAIPSNQFGFVIFDNNSMQVVVSKNTEPEIEVFVGKHMKNADLPWITKEIQIAIEKMTKISGNTLPLSKITVVSAALAETDGSHSLGLIIIKSLLFEYPKFARTTTVIVKEVIEQWISSMLTVCDTSMKTFYLQESLATYLEWIVTEEIKFPNMTVKERFYEARQRILPSEQLRSSSLNTFSEAERTAVFFYSLEQFYNRTIVQQFFGNLFKKFGGKECVTIENIADTFAEVTGSEVSKNIILSYANSDDEYPLIKVDHSSSTGSLKINIENGSNKNSSSILPLKIVDATLKETYHIYNQSQFTVYEPTKFLVVDPDSVGYHRSIYNVEPYSSLATCFNSSEECILKKSIIKTVFSDFCWALFENKLENDKENLSQWHSLFRKLTTVDHLIEGECSCCIRSQTSAKGKCLWIWKNRCGNLALTNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAL4</accession>
    <name>A0A914YAL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16321.t1">
        <property type="protein sequence ID" value="PSU_v2.g16321.t1"/>
        <property type="gene ID" value="PSU_v2.g16321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16321.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26084" checksum="FF3CAE1111B56D51" modified="2023-02-22" version="1">MRGFSSSAEIRSAAMPRRFNNNINPSQMMSPSVIGAIPYPGGTGFYQTPLQNPFLIPLTQSQPFGNFGQQPQNMGPSSLASVLGIAAPRGGAPPPIMGQQQGGSRCPTSPFAQFLSKDQQDVLHELIIEARRVGAPEAEVKQYVEKYVKEILPAEKFQAFQEASNDFDRRLTLYRRGKRETGIPRRFDTITFRNRKTKKPPQKLEITDKNELYDFMEVQKDARTLENLIEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBD4</accession>
    <name>A0A914YBD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBD4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14799.t1">
        <property type="protein sequence ID" value="PSU_v2.g14799.t1"/>
        <property type="gene ID" value="PSU_v2.g14799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14799.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10482" checksum="CE776DA713174980" modified="2023-02-22" version="1">MATIIFLSILEFMIIIALALFQDHSNFSNRIALERKFETLHYKLPINICIAIFSFWCFSIIQSCYVLICELKSAKINPNLNIELAPLHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBJ9</accession>
    <name>A0A914YBJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBJ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14863.t1">
        <property type="protein sequence ID" value="PSU_v2.g14863.t1"/>
        <property type="gene ID" value="PSU_v2.g14863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14863.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18874" checksum="BC49700B55C9E38A" modified="2023-02-22" version="1">MYYQHFDYTDLQTISESNETELLKESNQTLEFLENNGIKLFKEMNPNQTFFNENGTDYINLVNTVTVVWLKIKDSAPEHSLLIENQNGENIHESFEIKLEVNGRDPEKEVEFLLNVLKINLKNELCVPRYEFLGFVRYIIFVNETGLLKASVSLCLINMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC72</accession>
    <name>A0A914YC72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC72"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1703.t1">
        <property type="protein sequence ID" value="PSU_v2.g1703.t1"/>
        <property type="gene ID" value="PSU_v2.g1703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1703.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9157" checksum="32385A05E26829AF" modified="2023-02-22" version="1">MSVVDYYSHVQDNSLARVVEEVGRDGNRNYNPRKEQYKDLEKKFAQNEPHIKEIIKLTAEIRVNILNSFEIKTKYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCQ3</accession>
    <name>A0A914YCQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16528.t1">
        <property type="protein sequence ID" value="PSU_v2.g16528.t1"/>
        <property type="gene ID" value="PSU_v2.g16528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037861804" evidence="2">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16528.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21971" checksum="74BAA0460522B90F" modified="2023-02-22" version="1">MLISLFLWSTLLLGTTCDFVRSPSLKQTDKKHIVKRQSNRFLVDEVGDDTAKSNSVPNSDDYSDFNNKPVENRASRKLRPVTYRPILPTYRTPRPSHRFPAVELTTLAPITAATIPPHAVRRVGYFFQHYPYDKLHRFYQLNPRLQFFYPREYENVEWSYPIERTPYYHQRQFYNLAALGYYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDM7</accession>
    <name>A0A914YDM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16855.t1">
        <property type="protein sequence ID" value="PSU_v2.g16855.t1"/>
        <property type="gene ID" value="PSU_v2.g16855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF477">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16855.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11415" checksum="DCCFCE2D403CB636" modified="2023-02-22" version="1">MLGLELIVRAHQVVEEGYEFFAERHLVTIFSAPNYCGQFNNAACVLVVGADLVCSFSIYRPEPYTNKGDAKNARALNPKKSGPRVYDKDGKMIFGLPAHVQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE52</accession>
    <name>A0A914YE52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA mismatch repair protein MutS core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18527.t1">
        <property type="protein sequence ID" value="PSU_v2.g18527.t1"/>
        <property type="gene ID" value="PSU_v2.g18527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF145">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="1">
        <location>
            <begin position="281"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18527.t1"/>
        </source>
    </evidence>
    <sequence length="484" mass="55982" checksum="248E84D954B5D213" modified="2023-02-22" version="1">MEYKPVLPYLKNKAAGSAYVFLRKDSRDLFNEDARLVADEILMSDVSMKTHQLDDQDLTVLSLNKCQLNRVIRDLLLIIRCRVEVYEESEDGKTFELISKGDLTNYDDFAEIVESSVELGELSSIMSIRLHGKDSSEDNNVSVVLCNLRDMRITVAEFTDTPNFYYLSECIQNTVPRECLIYKSDADVRPEGYKNLLTCLNRSNVPNIDSRLSSDEMEKKKADFISLLFKPLKGFTEPSFSKNILETAAPLFRHLRLLPDYQGKFFLIEYKSVGHLHLDSAAVRALELFSLVQDDDDEPARGIGTLYDHINKCRSDSGRKLIRTWMRRPLSDLRRINERLDAVEALIESHTPRTALSDSLLRQVPDITSIERKLLQKKANLHDCYRLYRLVELLKKFDSVLMDLHDDHSEAKSAAVKVLMWDPIQQCIQELNAFARIIDDFVDIEYADKNDTYRIKPEKNDQLSECWKSMERLEKQAHKLHDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEY2</accession>
    <name>A0A914YEY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEY2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17865.t1">
        <property type="protein sequence ID" value="PSU_v2.g17865.t1"/>
        <property type="gene ID" value="PSU_v2.g17865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22084:SF4">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22084">
        <property type="entry name" value="GEX INTERACTING PROTEIN PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17865.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="30100" checksum="FE53065C5712C20D" modified="2023-02-22" version="1">METRSAKKIKNCADANARYHRLSESEKKELNKKRAQQQKRKRQRNKEIAELEAVLRQTNDIVDDSQTVEQLSEQKMRTKWTEFENLRYQRMSSEERDAYNDKHRMCQIIVKNENDEIVDVKEIVKNENDEIIDVKENVKEDVKAHNLRKALSARARYHQMTPDEKKLYNQRRSEAIKRQRLENEALLATPIELINDEIFERVQNVIARNAKRSENARLRYQRMTPEERKEYNRKRSSYYKKKNVKMEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF31</accession>
    <name>A0A914YF31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF31"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17922.t1">
        <property type="protein sequence ID" value="PSU_v2.g17922.t1"/>
        <property type="gene ID" value="PSU_v2.g17922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17922.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14165" checksum="CD4A913E945778A8" modified="2023-02-22" version="1">MNNLSTFTSKNDNNATPKVLSPNDPRLKEISQQIYNLIAFRNKPEVIAYDLLGYYGTNVEKLMKEYGFDKSSFQSFFTQMGYQFDSKGRFVLPPTAPIIVKTFRDVLYTEEDDDYACPPVPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFH9</accession>
    <name>A0A914YFH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RWD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFH9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19058.t1">
        <property type="protein sequence ID" value="PSU_v2.g19058.t1"/>
        <property type="gene ID" value="PSU_v2.g19058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="7">
        <location>
            <begin position="69"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19058.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37125" checksum="9C17CD235D1AC50F" modified="2023-02-22" version="1">MDLLTIEDLMIEGKIKDINDLEIYCHLITTNAVVFAGIPAEAEEFAEKLINIFHLINFMKMLLSQESEEEITAVSSIFYDIITVESDRTILCSFPSFNIDIRFTLTIEYPEKSSPIIEVCGPSVSAEIKHNLKERLENICNDKLGDLILYDCITSAKEFIDVLKLEVKNEKEMIENGNVSSDSNKNKEELKIKVPEIYGTDTLTDRKSIFQAHVARINSKEEAMAVLETLMSNSKIARATHRIYAYRTYVTKNDKKLPLNDCADDGETGAGIKLQHLLQIMKIDNVMLVVTRWYGGIHLGADRFKHIQNKARQAIKESGIEKEQTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG81</accession>
    <name>A0A914YG81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YG81"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19307.t1">
        <property type="protein sequence ID" value="PSU_v2.g19307.t1"/>
        <property type="gene ID" value="PSU_v2.g19307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000012">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19307.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24590" checksum="E79BEC64C4248042" modified="2023-02-22" version="1">MPLKSQILAEMEVEYQKLRFLENLLYTSPTGYLSNCTPSLQSSLSISLPSIPQPLPQYPLPPSITPTSSNIPSSTTSTPLLMTESNEVKKVKKSISPLVIPGPSSSSSLSDRPHQCNECGKRFKFKSNLFEHKSLHSSEQAYQYVCPFCSKSCRLKGNLKKHLQIHMGTADQLEKFWKVRFSRSSGRPRKVVVSPVQSFPVASESLKQSFLKDLLLDVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGK2</accession>
    <name>A0A914YGK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19432.t1">
        <property type="protein sequence ID" value="PSU_v2.g19432.t1"/>
        <property type="gene ID" value="PSU_v2.g19432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057591">
        <property type="entry name" value="TMEM126-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23408">
        <property type="entry name" value="TMEM126_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19432.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33493" checksum="EF41403B66FB4FDA" modified="2023-02-22" version="1">MVTSNPSATVDPVSIWVRSQILDSKEPNLPNDLISKTDVATRYAGQRSALWTSISEMAGPNRQKFISRMVKNWPYAKERYALIFPMHAGLVSSCLCANLIAARINSDIFLYNPKISFLQSIRRCPKSPWVFAIYTTGITYFAFYNLFFEKTILGEDEPCTSCTLSRLSTLLIGAGVLFPAVTTPALSHYMHVRHNPGVPVTKNLLEFVTMLFVTSKSTWSLLPKLAVCQLIVASVSTYSLLWGRSRIFNTVAIDPDILTETVISAEKEKTVKEKLNSIFSKVSFLRSFLDDPTEAPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH44</accession>
    <name>A0A914YH44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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    <sequence length="276" mass="30755" checksum="CB5753800BADE788" modified="2023-02-22" version="1">MTLQGSNIPQPPVIAPYFGHRRYNPGEVVERGSLPSDPKPPKLSTPKPKTRMTMEDFENMMGAVEEESTAEFHAPGGSEGVEKGHYDEANDAMPGARPESESTAINSQLDSKPDKIAIEENPAEPNSVSPSQVQPADMPTDEGEEKGPYAHLRLKPFARQNKLHSLRANDSTAIDTTENENVQIRTSSQEDPFEIDGESTKKIYKEIFDLSMCQLRPSEGRQCREDESQPLTNLQYFYSIKDRKCKLFFHRGCGGNSNRFDTKADCEKACSSLMGH</sequence>
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    <sequence length="263" mass="28648" checksum="148BFFE04783C77E" modified="2023-02-22" version="1">MMKQIVLVSLCLTVAQSFLFGGSSGGSGGGCCCEPQCGPPQSCCAPPPPPPAPCQCAAPQPCMQQQQSQIYQAPMNQNLPLCRPRYIIIRPLEHYNSGYQQQQPMGPAPMQQQQFMGPAPMQQQQGGGGSYAQAPQPIPQAPVQQPQGQQYVQPAAPQQGPIETPQQAGYKALASKTQNDDAKCNSIELRSIMESEITPSNANESKRRIHKIANEQFETENSDRGIDVICAASEFSYRIATDLYCEHQKADITCFAYQQSQPQ</sequence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18327.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18283" checksum="5F587DAEF3A0A9E1" modified="2023-02-22" version="1">MFRMAIKMKAELEDAKLKNAELIEYNQKLQDINLHQSNTIREEMVKNVEKEAEIVRLNGNITILQARIADCISTNNQLKKDADIERERINEMVKENVQLKAVMEDDKQKNFIVKDLEYRYNQWKGDGIKLSFEHLAFQVGVKESFFCTEFVFIYS</sequence>
</entry>
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    <accession>A0A914YII3</accession>
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        <text evidence="1">Belongs to the cytochrome P450 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        <source>
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        <source>
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    <accession>A0A914YJP6</accession>
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        <scope>IDENTIFICATION</scope>
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        </location>
    </feature>
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        <location>
            <begin position="212"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19085.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="27911" checksum="0C6C122A6DF99079" modified="2023-02-22" version="1">MLLLAERFNLPVLKMVSSGALVDKLISSSNQPNENAMHKEFLQIAEKITTTEEEDADDEASTTSDNVECLVHNVVNELQSLAKHIRRVSLSASCGSLNNSPGSSSSQTSQTMSLPGVFAAPQPVHALSPVPNAGHIPPGGRRSSLKTSRELLNFTGNVGSLDSENASSINNSPLLGNHPTSSSSTPITTTTNPRRRSIMFSLQTFRFEDEDNFQEEMESSVDEGVGSSADSNDGQTSPSQQPPTLRITSDTTSLFALHVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK87</accession>
    <name>A0A914YK87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YK87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19284.t1">
        <property type="protein sequence ID" value="PSU_v2.g19284.t1"/>
        <property type="gene ID" value="PSU_v2.g19284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="2">
        <location>
            <begin position="50"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19284.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26075" checksum="D47C51E9D9E5920F" modified="2023-02-22" version="1">MLTFFRRSLCTVPKVIYTHRSGRMVKEKAAKAAVAKAKGGGALILKTPKGTRDYHPKQMVIREKVLGIITDTFKRHGAQTIDTPVFELRDVLMGKYGEEGGKLVFDLADQGGELCSLRYDLTVPFARYVAQNNIKNIKRYHIAKVYRRDQPVMTKGRYREFYQCDFDIAGEYDLMVPEAECLRVVDEIMNQLDLGEFEIRINHRLLLEGMFSICGIKDADFKTLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKC9</accession>
    <name>A0A914YKC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKC9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19794.t1">
        <property type="protein sequence ID" value="PSU_v2.g19794.t1"/>
        <property type="gene ID" value="PSU_v2.g19794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19794.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8813" checksum="D3AB3E6957718305" modified="2023-02-22" version="1">MAGSTAATPASVQFPHIPPFAHDPSDPTSATTWLRQVEIKYAFVPNLTEAHKVGLVAAVLDAETFKRVDRALLPEDITTLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKL7</accession>
    <name>A0A914YKL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKL7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20073.t1">
        <property type="protein sequence ID" value="PSU_v2.g20073.t1"/>
        <property type="gene ID" value="PSU_v2.g20073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20073.t1"/>
        </source>
    </evidence>
    <sequence length="874" mass="99796" checksum="2FE63527505A3361" modified="2023-02-22" version="1">MEARVNEFGDCTGNETEKIENDPEQFDLLDLPFEKCKKIKFEEMEKVMIEDGCWKAVAVVKQRCRQLQKCCPAAKICMKSGRNSDATKEVRQKHIEINRKTLECRNNMKKLLDEQKKNGKGFNELLNARAHAVLTAQGDTLMDAIQKKYVFNKKERHEMRIMRKELNPSKSVVSLSPPSSNSSTTNFVAPKNNNPIRHLAKQSIQKIILKNNRKPKVKKGRKQTPNNNPLILFNAPSVPDNVKHLGRPPSQMLNTIKPHLPTTITTHSSTPPAMKGNRLQQFEEFENMLHTLENDGTKKFGVKIVTPKKHPNIQSLINSKNTSPKTAIKNNVFPTESQIRNGFIPRFKSINQPQSFALPPTVNLTKMNMFEARPELKIQMRKSFKNINNILGKPGLEKSQTLRPRIQSIQTQTDFDKPIMNIFKIDQDLVPFNNKELSPEAFVGHDGMWTLSPEALTTPAKSFVENDKASLHQQSFSDNEKKEFEQKQLKSSMPSNIVIFNNQENPMPTVSEFSAETPSILRTTMKAPIQEFLKILKPVIAPKIKMTEADESEMLVVKEDLIKNLEQFVKNNAKKQNEKQKLSIESSRIEMLRTSQEEFKAEQISMDYCKLYTVCSEEQKYVSKSCEGNNGKLIPGLPRRRFGKCNKRLVTDYKRMNSMKQKVERLFEKCLSDKIALNDASSISETCPKEWPILPEFEQEATCIHRVRLVQNHCAKLSRCCTAAQDCRLSVDEMPVSWKLIQKEEAVAKASAKCQIKAYNDYLKYKTKRFGDVKVEKRGGSKNDIRFGSNRNHASKTSPSIQIQSTTITTTPKPLQLFTTRIPASSKKSLPNRVFPEIIHVGTFQPQSQSIQIPDEKLSGLNRIDTSHVKLLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKT9</accession>
    <name>A0A914YKT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKT9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1996.t1">
        <property type="protein sequence ID" value="PSU_v2.g1996.t1"/>
        <property type="gene ID" value="PSU_v2.g1996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1996.t1"/>
        </source>
    </evidence>
    <sequence length="626" mass="72933" checksum="1B40707C6DE05CCA" modified="2023-02-22" version="1">MKPEKLYICILIGIFSFLFIINIFSTFSAPSTLAFYPLEEHTKYEILKSNNISTASSSSSSENNNENNNNYQCILETPDPWDPTIPAKYFITNLTKCEAKYQGLTSLTDGFVKINFNIAKENTTCQWQCLIPNRYDVEYTTSKWFEISERSECDSIKVQCFSNYDDKYYQDLHCQVIPKKVPELKQTSKNLPKYNFHIFVVDAVSRSQGKRFLPKTIEFLENNMEAFHFPFFNKVAWNSWPNGGAFLFGKYPTKDNIPPSITKPLCDNQTFEKHYIGNILQNMGYTTLFNEDVYSIFEKTFVNSTHKLFPLGEEVKKTKTYKAGLLYDDQCKSGLDYNVEMFSKFIDAYDTNIPKFSLNWNSQTSHDQLNYLWIADDILLGFLKKYQKELDNSYFILMGDHGPNVGEHRFSHETIALEERNPMFYLSLPKDLRKDENIIVKNLRQNKKKLISHYDLYATMIDIAESVGAEIPLDTIFHGKSFFKPIPEGRDCGEMGISPMYCNCRYKKANLTSEDPLYQQIIDSIFSKMNETIAPFTDICVVPYYSSKFQPIIKEIFYPGTTKTLKIYQVIFETLPDDGRWETYVSVKFHRDSIEIQNFLNFGNRLNPPWAKRCSQTIRDFCFCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL58</accession>
    <name>A0A914YL58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21084.t1">
        <property type="protein sequence ID" value="PSU_v2.g21084.t1"/>
        <property type="gene ID" value="PSU_v2.g21084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21084.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20354" checksum="38A72EB32B92A19D" modified="2023-02-22" version="1">MQLILNELDRDVFRFLILIDPEKEVTWDNVRECRYTRPLFGAGSSPLLLEQVITYALKRCPHDVASEILKNLFVDNVLLGAASIEEVLMKAKLAKSIFDEMQMNLRDFISNKKSISDAMDTVVPEKTTFLGIPWLPESDQMITVIPKFKSTTKITKRIVLSAIASIYDPPGLLAPMIVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLE5</accession>
    <name>A0A914YLE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21165.t1">
        <property type="protein sequence ID" value="PSU_v2.g21165.t1"/>
        <property type="gene ID" value="PSU_v2.g21165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21165.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9052" checksum="0C0800FFB25AA46F" modified="2023-02-22" version="1">MTMDSGAGGFHRGIQGQDIGLEGNVADQFGDLAHFVRAVGNCVDGIEQAVYSLIAPGHLAGGVLRQMIGGLGLLRVLAHGVSPVDSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLX0</accession>
    <name>A0A914YLX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLX0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18313.t1">
        <property type="protein sequence ID" value="PSU_v2.g18313.t1"/>
        <property type="gene ID" value="PSU_v2.g18313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40288:SF2">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40288">
        <property type="entry name" value="PROTEIN CBG16535-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18313.t1"/>
        </source>
    </evidence>
    <sequence length="470" mass="51865" checksum="8F78B766EAF8B7C6" modified="2023-02-22" version="1">MVGVDAIIFDVGLFHSLWGIQGCVAQHLDGGYGRFGWCITHILAFCFSLPFAFCTHPRPRMLWPLLIMQSIYGIGLLILSLAALPRILPTFMGDIGNAPIGAILVYVFGAAMNYMLLYWYWHWYWFIESEYESATKLRHNRLSNEVHSDPRRRPFHYPSESLFHANGFSPQSQRILLGTSPPGTATTTTTTTVQMIPNGTSMIKQVPYPSRQYQNHQQKLQGNGTAKRDEHNYSKPVQQQQPPPPPLSSNFNGGYIPSENGYYGPMIASPMSQQSQRESLISNVSNLHFSKMHQQQYPQPTPTTISQPHRLSKSFYDPIPSDLLSPQCLSDDYPSDDSATAPILSHSSPHYSPLTGSSQSKYRPTNFTHALKQSSSVTSSPGGGLGGMGYATLAQARYAKFNNSQPVSFRKTSITPGGAPLIGNRIASSSQIQIPQQHSQGCSSISSPSRPSSHSRHGTPIIGPMYSTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM24</accession>
    <name>A0A914YM24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19968.t1">
        <property type="protein sequence ID" value="PSU_v2.g19968.t1"/>
        <property type="gene ID" value="PSU_v2.g19968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19968.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26438" checksum="3EA57483C9538407" modified="2023-02-22" version="1">MIHTPCGIHNPNAPCMVNGKCKRRFPREYREDTEMDVNGFTLPKCPKNERSFTMKVKGKEVTVDNRWVVPHNPHLLKYMKSHLNVEAVNSIATVFYVFKYMFKGDDKAFMEMNDSIDNEVHQALNYNEVKSYEDFRYISAAEAHWRLSDYWLYRLSHSVDRLPVHLEDEQSVYMGENPDEDEMKNAAKKDSKLMAFFKINQEKQKQIDEANATIKKLRSEGLCLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMM9</accession>
    <name>A0A914YMM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20188.t1">
        <property type="protein sequence ID" value="PSU_v2.g20188.t1"/>
        <property type="gene ID" value="PSU_v2.g20188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20188.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21241" checksum="63ECBDB4E1C5D796" modified="2023-02-22" version="1">MCDTSSTKPLSGISHALKHYRLPINLVPYLPIGVDICLLELNEFIFNDNITKPIQISSKIDFEENANLTIVGYSWFRDINDTSTFHNSRHSSISFLSVGDCKIKERDYLICVGGDNIDEEDVKYQANDASPLIYQNDEGDYMLTGMVVRPSEYNSTENRFQATATFLPMWCDWIRYITREEVTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNB6</accession>
    <name>A0A914YNB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNB6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20457.t1">
        <property type="protein sequence ID" value="PSU_v2.g20457.t1"/>
        <property type="gene ID" value="PSU_v2.g20457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12797">
        <property type="entry name" value="M23_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="entry name" value="Glucose Permease (Domain IIA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050570">
        <property type="entry name" value="Cell_wall_metabolism_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="M23ase_b-sheet_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21666:SF270">
        <property type="entry name" value="MUREIN HYDROLASE ACTIVATOR ENVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21666">
        <property type="entry name" value="PEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="Duplicated hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M23ase beta-sheet core" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20457.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11056" checksum="EEDB7462A56F87D5" modified="2023-02-22" version="1">MKGIEIVPEAGGTGLVQVVSSDAGRVLQVLDDPENGTTVVIQHSGQVTAIYGRLNESEVQVNDWVEAGDAVGSLKETGNDQPATLYFAVKEGEQYVDPAEVVALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNE9</accession>
    <name>A0A914YNE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isocitrate lyase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNE9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21132.t1">
        <property type="protein sequence ID" value="PSU_v2.g21132.t1"/>
        <property type="gene ID" value="PSU_v2.g21132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21132.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21670" checksum="0E710DF20D114808" modified="2023-02-22" version="1">MGGKVLIPIEENIRHLNAARLAADVCGVPTIIVARTDAESARLLTNDIDERDHPFIDREAGRTPEGFYRLKDSTALESCVARAKAYAPYSDLIWMETSHPSLSDAKEFSEGVRRDFPDQMFAYNCSPSFNWQKHLRPSDMEQFQKELGKMGFKYQFITLAGFHANNYSIFDLAKNYRERGMAAYSDWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNL3</accession>
    <name>A0A914YNL3_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNL3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2451.t1">
        <property type="protein sequence ID" value="PSU_v2.g2451.t1"/>
        <property type="gene ID" value="PSU_v2.g2451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF9">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2451.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19182" checksum="19A0B4653C2B3596" modified="2023-02-22" version="1">MSHLSPSDCWSILSSSETSDTVIQVFEACCRHILGERHTFCIGLNCVYLTPKEKAWIRDGTITDSKWSLENDFMFYGWRESYRIPTIEENGAWTRASKRLLYSSWYSPLAPMTFDKESCNNGTILWKWYQSLLISTNELNKIMENVREKSQGDFLKALSIIPNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP36</accession>
    <name>A0A914YP36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20742.t1">
        <property type="protein sequence ID" value="PSU_v2.g20742.t1"/>
        <property type="gene ID" value="PSU_v2.g20742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20742.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16937" checksum="13F33D2F810F7C2F" modified="2023-02-22" version="1">MYYNGQSLPEIAKFLKKEQNKYMDSSQINKIADITNRISKILGNTENTAKLIELAMNITLNFIVGDKAQVDQKVAEVKATSNDIGIAKQEMCRLIFTLYTPEKRQQLAKQVLEHISQDKRAQIRDILGEIFRVDDIDINNISTASSNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPQ3</accession>
    <name>A0A914YPQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2800.t1">
        <property type="protein sequence ID" value="PSU_v2.g2800.t1"/>
        <property type="gene ID" value="PSU_v2.g2800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036918764" evidence="2">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2800.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14540" checksum="75307589158C0D13" modified="2023-02-22" version="1">MLPLLIFAAFLLFIICQTSVARSISYYQSGNPLDLSDSYLSFNQQHQQQQYQQQQPQHHFQQQISEEESSESPERHQLEKRRLVVRVPFAQSPDSIQLHRLYKTLFDNNNTKQKKFMSLQALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPR4</accession>
    <name>A0A914YPR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21449.t1">
        <property type="protein sequence ID" value="PSU_v2.g21449.t1"/>
        <property type="gene ID" value="PSU_v2.g21449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21449.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17348" checksum="9B05330900D7F53B" modified="2023-02-22" version="1">MLETVYDSRLAPVVPSILVERQQSEAPSSASLQVFPGVVPSYPIIDLTGSSSNSRKRPGPVKSEQLELERQKNRLYWAAYYKSYLETGPEQKCPFSKSYLSYLKNQASAYYLQTGVSINTGGFTRSIKGQAGHDSLALLSLRYFKTYNPEFGNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR69</accession>
    <name>A0A914YR69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR69"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2510.t1">
        <property type="protein sequence ID" value="PSU_v2.g2510.t1"/>
        <property type="gene ID" value="PSU_v2.g2510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2510.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24563" checksum="4BE428F7988B5EB8" modified="2023-02-22" version="1">MFADTEPFQLILSESEEESEEEEESEEEDEEKSEDEEKDVVIDIVEASSLPCSADSDTSVNSSFVEVQKSGKFNNICETSHKKSRKRRRSELSFSSQSDKSPSPSILGSNGDKVLAQIMIPKCHQKSVDIEELQDLVNENDKRRRIFDEQIYEMETSIIENSFKIKKVANEIKKVKRKKNDLVEDYTIKEEDRIFSGASASFQPRNIFEDDNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRC9</accession>
    <name>A0A914YRC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRC9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3318.t1">
        <property type="protein sequence ID" value="PSU_v2.g3318.t1"/>
        <property type="gene ID" value="PSU_v2.g3318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3318.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="25385" checksum="CE5E74BC6F0D21B5" modified="2023-02-22" version="1">MLIDVPSTAEIIQKCLTVNPFELKFREANRRISQSQDGLDQNSLVAPSLNLPTSAGLSMLKLQSSLSQSPTIFSNINLLSADLDFTRKLRESGFMNTTKGEGNRTPCTADVLNAVLDMNMNNPHMAAAAAAAVGNSNNCMSTIPFSSAQSIITSTSMPPASTSMSEPNFAFPSSCGSSSSKMDSTPPAPPTVQIPSSLSMPMSASQMSDISTQSASLISLQPPINITTSFSTGHLSELTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSW3</accession>
    <name>A0A914YSW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4291 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSW3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3253.t1">
        <property type="protein sequence ID" value="PSU_v2.g3253.t1"/>
        <property type="gene ID" value="PSU_v2.g3253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3253.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21065" checksum="4AA4EB3B3E0FA1E1" modified="2023-02-22" version="1">MALDTTFQQIRATFDDETITVYQAYNDEIANSAISAQTFISPPFILERMTWIKPSFLWMAYRSGCASKPNQERILAIKIKRDGFEWALKNSSSSQSKNCKSMPVRIQWDPERSIKLEKLLHRSIQIGLSKEAVNKYVNEWIVEISDVTDVMKEIEKCVKNENFNAAKEMLPKEEIYQFLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSW5</accession>
    <name>A0A914YSW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSW5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3785.t1">
        <property type="protein sequence ID" value="PSU_v2.g3785.t1"/>
        <property type="gene ID" value="PSU_v2.g3785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037364014" evidence="1">
        <location>
            <begin position="20"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3785.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41589" checksum="5D62EBA287935236" modified="2023-02-22" version="1">MIIFYLFCVLITLIGRCCGAVFDPYCRRYDLQKSTMNNLLSKQDGNTVLTKSLITIAQSTMTIPEPKKSILIEDLTDLDLTLGSGDTIIDFIEYVKELWRIQNLYHPELVDFFQTLRFKNISTWGPLENVYALTDQYYILGSSSSNVDGIWASIKTQKANGYCQLYDSLLTAASNYESGNAEALAYLQASYSPQMCTVTEDTMLLWHKMCEGDIPADIKTFLGDLFIGDFFYFNEFCRAAAAYRRLDIYDKYFGTPDPLLVRTMNNSVFSPQAANFTITQKGFIKQTYSYFTQKFPLLSSIPQRQNLVEMKFSEILDMSYSYFQAFNYVQMEKYDGNFYEMIRHICQRNFLTSEFNKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT39</accession>
    <name>A0A914YT39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2825.t1">
        <property type="protein sequence ID" value="PSU_v2.g2825.t1"/>
        <property type="gene ID" value="PSU_v2.g2825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2825.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13483" checksum="6E540F94B2260714" modified="2023-02-22" version="1">MAHIWECNVHKQVFANNIMVIMLYVPMDFAAQHRFKINAQMEVTIWLGLVPIIKFAKVILVPPQFAIMETVAPDLQSQIVAPIIQLFSADNAQIIKHVKVFTESIHSVTMAPVVQPLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTR0</accession>
    <name>A0A914YTR0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proline dehydrogenase</fullName>
            <ecNumber evidence="6">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914YTR0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3377.t1">
        <property type="protein sequence ID" value="PSU_v2.g3377.t1"/>
        <property type="gene ID" value="PSU_v2.g3377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000012">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3377.t1"/>
        </source>
    </evidence>
    <sequence length="644" mass="73832" checksum="6CE39E29DBAE544F" modified="2023-02-22" version="1">MPLNPGKVSSISTHSLLLNAYRLGVWQPRLATPSYLIHRQNHNSSQTFLKSHNSPLSRASVVSVASSVTPSTEVIQEVDKCYNKLDLTFENAREAFKSKTNFELFRALLVLRLCSVDFLVQQNQRILQLLRKTLGPTLFKRILKSTFYGHFVAGENLEEIAPTVQKIRNFGVKSILDYSVESDISQEEAEEKAVEGIVGDQEIPQAVEGVVDEKTIEATHQRYTVHKEFGDRRVDVINARTYFYTSEKECDKNVEVFCNCIDAVAEATRREGFTAIKLTALGRPQLLLKLSETIAQTQNFFKALTGSTWENLVLGKISEDKFLKRLKEFGIKTDSKMVQEWFKMVDFDDDGFVDYYDWGRLLDENKELTSMFSVLNIKTGKVEPLIQNLSQEEEQEFANMMQRLVHVADYAQEKGVRIMIDAEQTYFQPAISRLTVALMRKYNKNGGQILNTYQAYLKNALSNIEIDMHLARRENFHFGCKLVRGAYMDQERKRAKAVGYEDPINPTYESTNDMYNKCLGRIIKEREERGVGQVSVMVASHNEQSVRNAVQMMKDSVIAPSERVICFAQLYGMCDQISFSLGQAGYSVYKYVPYGPVEDVLPYLSRRALENGSMLKKVQRERNLLWREFKRRLLSGQFIYNVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUA2</accession>
    <name>A0A914YUA2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hypoxia up-regulated protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2105.t1">
        <property type="protein sequence ID" value="PSU_v2.g2105.t1"/>
        <property type="gene ID" value="PSU_v2.g2105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2105.t1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43043" checksum="4B25CDC94654388E" modified="2023-02-22" version="1">MLTTNNFQAIGIDLGTTRCCVAANRRNGFVAIPLDTTGERLLPSYVSYNEKNVICGKIVVNRLRNYSKSTIFDSKIIIGREFSEIEIDESWNFNVKNENQKIKLEIQGFNEKLKIITAEEVAADLLKYMKEKAEEFQGEPILKIVITVPAAFTNSQKAATITAANLAGWNEVKLLPEPIAAAFAYFNNRSIPNNSTVLLFDLGGVTLDVCIFKVENDMIKILTNIGDSKLGGRNFDTVLINFFKNMLNTKYGISVIDDKKYKLMLECQKIKEDLTSILSSSLDIDEFDTTKDGNIFITRQEFQRMTQPLLNKVRNTIQSALFKSKLDENKINKVLHVGGGSRMPMMKALLKEIFPNAEHCIEEHPDEVVAIGAAYYAYSIFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUD1</accession>
    <name>A0A914YUD1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUD1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g36.t1">
        <property type="protein sequence ID" value="PSU_v2.g36.t1"/>
        <property type="gene ID" value="PSU_v2.g36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF18">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g36.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14103" checksum="EAFBD9E345F1D872" modified="2023-02-22" version="1">MLKKRFAFISLKIVNFNENSQILTQKLEWKASPKVGSLANASHKPAGGDVKIFNQKVKVDAAQSKVGSLENANHKPAGGNVNIKEYKVAGNSSSNSVTSHSTGNSRRSSTTRTRMPGCHDPISPEEALGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUI7</accession>
    <name>A0A914YUI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUI7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21144.t1">
        <property type="protein sequence ID" value="PSU_v2.g21144.t1"/>
        <property type="gene ID" value="PSU_v2.g21144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21144.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14743" checksum="CF8090E385CE5DB7" modified="2023-02-22" version="1">MLPTYGDEEIAEFDANEIQCQLNEVENERAGIEVPMNLNLIAEYRTKLRECRQEGHILREITEKRDKIRQRLDELKRSRVEEFMEGFTEIALSLKEQYQKLTMGGDADLELVDPMDPYSEGIKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUM8</accession>
    <name>A0A914YUM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3689.t1">
        <property type="protein sequence ID" value="PSU_v2.g3689.t1"/>
        <property type="gene ID" value="PSU_v2.g3689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3689.t1"/>
        </source>
    </evidence>
    <sequence length="465" mass="51730" checksum="E61A695ED45996CF" modified="2023-02-22" version="1">MSEPKATTISTKLFTGFAPSASNSTDSGKFSSDNATGRLDAELAKTPQSEKPFAGFSSTKPLFTQSSTTTVTSLPSSTMPPFIPSVQTFQKQQPEPSKSTASVHKLPTRLTPSAPITAVFKPPKVADAPETPKPALPVAVRWLRLQRDYYRKFVANVKEFIENPENNELRRIIKMEVGNSVDKALQKRPTDVELTKSLAEFLEYLNRFLSGETMSSTLMPNKTFTFEPKSLNFLIHTLSVRIIVSLILKILSIIYAVLFCRKMVKQDPSLTDVAKLVHSVIASKLTTFKKIFRQILTNSMFLIQLTSDDLVVTLDEKLTADAGYFTLHCLDSDKSLFRLLCIIEMTENPQVKNLSDLCGIRLLYELSVACNSLPQIPVTTLSVLFEIMQTAGPALTAESSPYRKDFLQIVFPRLRALVEEDVSSAIDGITVRLAEQSFATHLTKMHSIVRQRVLDALEKIGIIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVW3</accession>
    <name>A0A914YVW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA ATPase AAA+ lid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVW3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4123.t1">
        <property type="protein sequence ID" value="PSU_v2.g4123.t1"/>
        <property type="gene ID" value="PSU_v2.g4123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="6">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4123.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8017" checksum="C3C09FC1FDEF4AD9" modified="2023-02-22" version="1">MNLMRGINMRKIAENITGASGAEVKAVCTEAGMFALRERRIHVTQEDFEMAVGKVMTKDSDKNMSIKKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWA3</accession>
    <name>A0A914YWA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4252.t1">
        <property type="protein sequence ID" value="PSU_v2.g4252.t1"/>
        <property type="gene ID" value="PSU_v2.g4252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036675955" evidence="9">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4252.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="55725" checksum="6BF27D6FF6ED2150" modified="2023-02-22" version="1">MGIHGSFGILVLFITVINAQQLFPQKKLFDQTYIIDPEAEMTVPEIIRRWGYPVETYNVVTTDGYVLVLHRIPFGKGGYNPGSKPVVFLQHGLLCTSSVWIMNLPHQSLGFLLADAGYDVWLGNMRGNTYSRRHANPRIRAQEYWKFSWSEMARYDLPAMIDGVLNITGESQLYYIGHSQGTLTMFSMLSENEKMNKKIRAYFAIAPIGTIANVKGLFRYLGENMYNELEMITLLFGDQEYLPNTFISRWLTELICGLASTNPLCQNFLFLVSGPDSHQFNKTRIPVYLAHNPAGTSIKNILHFCQMVRNQMHLDYDYGEKGNQQRYNSSIPPAFNITKIKVPMYLYYSDSDWLATPADVQGYLLKRLNKKYIKEVKHLHDYNHNDFLWGLRAPDDIYKPIIKSIRLDWVKWKAHLLHTTTVPTTTVTFMPSFNQLNDTNEDKDLLGSIIKPLSKTTKTISPSIFAATTTISTKDKNLLKPISEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWM4</accession>
    <name>A0A914YWM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWM4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2482.t1">
        <property type="protein sequence ID" value="PSU_v2.g2482.t1"/>
        <property type="gene ID" value="PSU_v2.g2482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024:SF3">
        <property type="entry name" value="C-TYPE LECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037402283" evidence="2">
        <location>
            <begin position="21"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="271"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2482.t1"/>
        </source>
    </evidence>
    <sequence length="613" mass="66628" checksum="3D77E465907C85CA" modified="2023-02-22" version="1">MKSSLLFLPLLLSTYNVAVTAGITVHNFPHKFGTICQETSAINYTTDCSVDLTIAIDMSSAMGNTANIATLTNSILTNFLPSFNFNETNTAGIAFGANNVGVSDYFNNYGDICGWIHSAEAEAIQIGLSDANLSAVFQDYEISLLHSGRNYKKVLALFTAISDPKEILTAKIYTDTLRTYGVYIIVGALAQPDASLLYQLGDYVFYSPDYTIPSFNVFNVTNEICQFGGITIYPDSTTPVNPSPTSSGPTDPRSNAIGTPCSTNFSNAWMDIVLVVDVSAAMGKEDLQQLAVSTAGYMQRFNIAQTGPHTTRAAIITYATDVTLRYSLLDVTNKRDLLLEFAKLVKYSNPSDTGVNVQAALKMAYSLLQNQTSFRAKAIILTAAAYDKVGFEGAAQTATTIKENGIKIFTVDFHTAGGVINTQLATLSSPGYSYIAQTDDIYNLIPYGLTQVNCFCPVGSLQFSVYDAISKNLTTYADCVWGVAVESLPSIVSLFGCDPGVMATVSSQEKLDFITDNILPYALKGKKQFSVGAHKSGTKWMWYGYNNNDGDDEFPLGNFPPLIQNSDSDQYTYFNKCPGFCFNFQSGGDVPRPYLCESRACDADFICDQTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXL2</accession>
    <name>A0A914YXL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CUB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXL2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5242.t1">
        <property type="protein sequence ID" value="PSU_v2.g5242.t1"/>
        <property type="gene ID" value="PSU_v2.g5242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5242.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23735" checksum="32338914CBA00EDD" modified="2023-02-22" version="1">MSSTTQLWITPVNAYLGYFGIDDWNPLTKAFIDIDTNTKIQTYLTKGLFETMSLFAVTKVDPLEWYAFQTVGITVDSLFGCPFNDMQITLNDSKTIIPIASTYYSLNSNETKYFPRTDCTWNFQTTEDFKFKLVYRYSEFSLNETMFAQINDGDPIDITYNYNIGESDAQYFDGTNLTLQYSAPQRKPKYYFYAVITVVKKGFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY75</accession>
    <name>A0A914YY75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YY75"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5052.t1">
        <property type="protein sequence ID" value="PSU_v2.g5052.t1"/>
        <property type="gene ID" value="PSU_v2.g5052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="197"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5052.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33384" checksum="8078B412F1099F9E" modified="2023-02-22" version="1">MTISKFVTLSNGVKMPIFGLGTWQASKELVYVSVKTAINNGYRLIDTAAAYFNEEAIGEALAETFKEGKLKREDIFITTKCPPPFLHPDKQEEAINASLSKLKLDYVDLYLAHMPCAYDGELKPEKILHDCKPEDIWKGLEKLYDKKLTRSIGISNFKIEQIHRVAKIAKVPIHNHQVELHLRSSWPAGPAPLENHIVQHLAKKYSKSPAQILLRHLIQKGIAVIPKSTNEKRIFENFQIFDFELDSNEMKNLYNIAQQPRLFWQDFLIGHPEDPYKEEREKQPQSKHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY84</accession>
    <name>A0A914YY84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YY84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4596.t1">
        <property type="protein sequence ID" value="PSU_v2.g4596.t1"/>
        <property type="gene ID" value="PSU_v2.g4596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020149">
        <property type="entry name" value="Uncharacterised_C02F5.10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17309">
        <property type="entry name" value="DUF5356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4596.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="25578" checksum="F7464909CBFCAA33" modified="2023-02-22" version="1">MADENSNSGKEKPSEIPKSDAATTSTSASETDSQKELKKETSDKSEKSGKEKEAKKSSKKKKSSKKRSTKSHQSKKKERKNRGEKKNRRTQEEPTFSTTPSSPSESDGGETLAPCSEKEWEHGSAAYNAALLNVKRKPNRVTVFALKKKGDNKDNKSASPKNAESSSGNNSLRSVSSNKLKKKTKNASMDKADQIGKIVAGIVRKYFDGKNEENIQVEIKLISNDGISSTPVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYL9</accession>
    <name>A0A914YYL9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYL9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5050.t1">
        <property type="protein sequence ID" value="PSU_v2.g5050.t1"/>
        <property type="gene ID" value="PSU_v2.g5050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048584">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21251">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="8">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5050.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23983" checksum="2C4C6DF028EFBD58" modified="2023-02-22" version="1">MALSLLSHIQKRHNTVNFFMRRSGQELWKTVTSVSKSGQKKGRRSTRQQIRPLEKFYKIGSGPLKIQFPGLNASTEKGLEPLIIEEQTEDELKQGTLNIRTILEETKATSKRRRREKLHPLERGFSGHNVVGQKLGPPPPVGDVALDDFQTYCLEVKRTSHMTRVFGRVHTMAALVFMGNGKGLGGYAVGKAAIHRTNNAIVKGMNMASRKFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ32</accession>
    <name>A0A914YZ32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ32"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3292.t1">
        <property type="protein sequence ID" value="PSU_v2.g3292.t1"/>
        <property type="gene ID" value="PSU_v2.g3292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3292.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14377" checksum="69E37C743DAD127D" modified="2023-02-22" version="1">METIPFRQRRSSLNHENFYERENNNEGFYGTPGSSYRRQNRSTNNNAQSSDYSRNQQQQQHHQNHHHYSDSDSRHHQSQHRRRSHSHANSRNNRNVGNNQRKSRDEGAYIMENPMYMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZB7</accession>
    <name>A0A914YZB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3380.t1">
        <property type="protein sequence ID" value="PSU_v2.g3380.t1"/>
        <property type="gene ID" value="PSU_v2.g3380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3380.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9556" checksum="DA92F18FDE5470E5" modified="2023-02-22" version="1">MSRNFHSTNSESESDEELKILSWKNAYEQQKQSSPKFDKFRIQDYQDLQEDYYKIIEIASELIDCLEQTCSGKTVSCESFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z171</accession>
    <name>A0A914Z171_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase metallopeptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z171"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5643.t1">
        <property type="protein sequence ID" value="PSU_v2.g5643.t1"/>
        <property type="gene ID" value="PSU_v2.g5643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF323">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5643.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31618" checksum="60263EFF63D6AA3B" modified="2023-02-22" version="1">MREVFDTWSDHIPRQFKEVATEFEADIKIRFGRMEHGDGKPFDGPDGELGHANIKGILHFDDDEIFKRYTRSDMITNTTLRDIYWVALHEAGHVLGLDHIRDFGSIMAPIYFTSMDSEGKYMEPSLVTTDITNVQEIYGGKTRPKIDTTHVANGGPYTAYAMVQKDREYLRSITFEFFQIAQKSKWNMTEIPSGTPFTEIVTGAFKAFNPQAPPNEMVYVTVFTHDIATGNVMKLVDGYEIVSDRGVVIGADNKLNEALTGKLWIDPKGIDHSRRPDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2H1</accession>
    <name>A0A914Z2H1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2H1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6271.t1">
        <property type="protein sequence ID" value="PSU_v2.g6271.t1"/>
        <property type="gene ID" value="PSU_v2.g6271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6271.t1"/>
        </source>
    </evidence>
    <sequence length="466" mass="54149" checksum="C518E92ADD7F26F8" modified="2023-02-22" version="1">MTETTMNEELSVSADKESEAQLNRLAIRIDIPTEGEYKEMEAVQIENLQKFNTDEFTDVQKLCKIFVEWDLLKTLPKSPQILSFDMEMKMIISRLRYEQAFKKASKGEFAKCIHKYLKSKKTEETTEFQMLQIAKIAKKVQALERKEGINCSKFMRPFTAEIIGYSACTEILFNEKRCKDILSKTIKECNEKVLSFIEYNQVESIWKKWSETIFVQKKPLEKHRLMLENAFDAIKQNYQADKAISDLKELIEGATKEEKEEIKRMEKESETNVEFIIKASKSKLRKKLNFIGAKILFAFIEGRLLTEACKALTNSLKLIIEAQSSAKDLIECEYKFEYSDVTQKWLQLLHQEKEGFQSDFDLIIECGAASAAGRSLIAYETKTNLRIYASEQMIENHYPEAKHVHHISLDPKSGALQLLAFNTNHVELCDYRENFGITFRQRLIRYEEHDFGIKGANLIDAINTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z313</accession>
    <name>A0A914Z313_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z313"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7087.t1">
        <property type="protein sequence ID" value="PSU_v2.g7087.t1"/>
        <property type="gene ID" value="PSU_v2.g7087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F13G3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7087.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="23156" checksum="59A0FE6448D085E6" modified="2023-02-22" version="1">MSVLKGVYDLLKEYEKQKIIDINFWGLPRHPNARNQLDWRNQAAAHADCYLKYREAAEFIIISDVDDFLFPRQGSNIYTELEIMAQSHPKMASFFYPRFESEIITTKKFKDFNIAESLQSIRISDKRQTGKSIHRTSFVETVWLHWADLKKDDAPYHKLDPADNAFIHVRNWTFLDKYDDVRLLNNVVRFFLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z361</accession>
    <name>A0A914Z361_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z361"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4695.t1">
        <property type="protein sequence ID" value="PSU_v2.g4695.t1"/>
        <property type="gene ID" value="PSU_v2.g4695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF17">
        <property type="entry name" value="PDF RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4695.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12281" checksum="2A4D756B88F4D12F" modified="2023-02-22" version="1">MLQLVVNTLFICNVIRVLWSKVRESHNTSELDRMKKSVKAALMLIPLLGIPNIMQTIPFSPTQENIVVSILKEALCYFFWMHLKIRKRKASEYNEIGFSVVENSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3B6</accession>
    <name>A0A914Z3B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4371 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3B6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6855.t1">
        <property type="protein sequence ID" value="PSU_v2.g6855.t1"/>
        <property type="gene ID" value="PSU_v2.g6855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6855.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32172" checksum="30C141B1C500D0E8" modified="2023-02-22" version="1">MVWIYLKNCMCLGKKHYQDDTEPVLPNSKNEHQNSAAENFDIEIFEDSNTKNCNKELFTELFNNLADLKEKQKFVDGIILTQSGYFAKNCSNDGTIKFYSGDVIANKDKIRKYQTKVKFVSKYGEAICTVINFGGHEMELKFRYLNLSNYGKLNGRFQASLCSNDKQLKHIEEGFRIITRHKEMVEKVWAQNSELIQNGPNMHIFENGRNAVEELIETNDSELTLICAETNDAVKSITAKLKKKMPQMFVDGLAIRLITQKYSNSAEYTKLSLISPIFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3I3</accession>
    <name>A0A914Z3I3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3I3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6918.t1">
        <property type="protein sequence ID" value="PSU_v2.g6918.t1"/>
        <property type="gene ID" value="PSU_v2.g6918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6918.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19694" checksum="A19BCE648367AFE0" modified="2023-02-22" version="1">MNISAVEQLAAIRAMKPELKECFPEFFHKMTDHDNSVSISNESRLTQNSSYFLTEQENYLNFAKNGSHFIPLADCSAIFPTTIQLFPSETQILAKEAFPDPEEEEEDGMETCTFIPRVSNNIEYVKFGKNKHKRKIDTIPPTRESVFYSNTLAIIAISIFLLVAMNTYYSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3S4</accession>
    <name>A0A914Z3S4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3S4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4903.t1">
        <property type="protein sequence ID" value="PSU_v2.g4903.t1"/>
        <property type="gene ID" value="PSU_v2.g4903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF365">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4903.t1"/>
        </source>
    </evidence>
    <sequence length="377" mass="38426" checksum="3CB9C921AE446835" modified="2023-02-22" version="1">MSEKAQLMGEFTENDLRHFRRVAFVAVALSTVTMLACIVIMPLSYQYVQRIQSSMTNDVEFCRSRNRDLWSEVVTVQLGKGQTERAERFRRSATGNSNGRWLFGHFIQTHNDRQAAISAQQNFAGREVRRQQPYAEARGDTAAAYDAGASAATSTGTSPNAPYAPADSAASLTQPRTISGEPCSCACGVGPAGPPGDAGPEGQPGRDGQAGEDGTPGQDAPPPQKGEPCVRECPVGPPGPPGTPGDKGPKGYKGETGVPGTAGKPGPKGPEGKQGPEGPPGLQGRPGEKGAPGKHIAGIAPPGPPGRQGEMGPPGAPGVPGEKGKPGNAGPQGEQGAEGNPGPFGKPGAPGSPGPDGEKGAQGPCDSCPKPRLPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3V7</accession>
    <name>A0A914Z3V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-glycoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3V7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6575.t1">
        <property type="protein sequence ID" value="PSU_v2.g6575.t1"/>
        <property type="gene ID" value="PSU_v2.g6575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002695">
        <property type="entry name" value="ABC multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF243">
        <property type="entry name" value="P-GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="215"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="533"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6575.t1"/>
        </source>
    </evidence>
    <sequence length="748" mass="82352" checksum="684DE648391CF228" modified="2023-02-22" version="1">MANAHDFIESLPEGYSTRIGEGGVQLSGGQKQRIAIARTLARNPKILLLDEATSALDTHSEAMVQTSLNNAAKNRTTIVIAHRLSTIRDADRIIVMHKGRFVEMGTHNDLIQRKGAYSKLVAAQELNMGDDKKEAAEDIVDDMLSPDEPNAALTVASKTVRESIRQSFLRDFLPSDHLGDAETEAYDIEIEKTGAKKARLGQIFLDARELWPLLAVAFAVCCFNALSMPLNAFIYGQAFRMFENGRKDNVGEAFVFFLFFLGLAAVSMVAAFFTTYLFGKIGEKLTMSMRVRAFRSIIYQDGSYFDNPAHTPGKLITRLATDAPNVKAAMDTRFARVVQGGLGLLTAIVISVIMDWKFGLACASFFILLGIIQFTIARIAHAHALRFAQGDEAGRIAIEAIENVRTIQLLTSEHNVHKNFMECSLKRQTAETRKAPIEALNFATTHGMQHFTLAFCYMVGFIFVLNGLTDKITLFQVVQTIYFGAAAIMAATEFFPELVKSRLAASLMYAIINRQPRTGNINAGEKIAIEGDVSFENVYFAYPMRPKHAVMKGISLQARPGQTVALVGPSGSGKSTVIALLERLYDPSVGAVKIDGKDLKSLCLFDIRNQMSLVEQQPRLFSGTIKDNIAYGLDISKISMDEIVEAATLANAASFISTLPLGYDTPLGEKGAQLSGGQKQRIAIARAVIRKPKILLLDEATSALDSTSEKKASKKHSNEKGKEGEGKKNSCDVFFRYHEECRRHRCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z547</accession>
    <name>A0A914Z547_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hyaluronidase</fullName>
            <ecNumber evidence="7">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z547"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7475.t1">
        <property type="protein sequence ID" value="PSU_v2.g7475.t1"/>
        <property type="gene ID" value="PSU_v2.g7475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038193">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037459532" description="Hyaluronidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="364"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="43"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7475.t1"/>
        </source>
    </evidence>
    <sequence length="432" mass="50004" checksum="EEC7ED55BED77A75" modified="2023-02-22" version="1">MTFIFLLILLLSSSSSIFATKELQHKPNATHFEAFWNVPSFACDKLGYDMDPRDYGIHANDHQKNYGSEVVTFYEQFLGIYPHISQKINKTTGETQNILYNGGIPQNVNLDDHLAKAAKDIQKAIPDPKFNGLAVIDYEGWRPLWQLNWYTRIVYRTESERHARQLFPDASDKSIIKIAKRLFNTAAKKYMVETIRLLRRMRPLAKVGFFDYPICNYNAGEKGESECVIKFDTYNQNLDWMYQESNALFPPIYLYKLDRDFEKRQRYIYAKVVMTKRVLLKMGIELPIYVYTKFEYNTYPGSAENRSNLYTEQDLCNTMHYAAELGAQGAVFWSTSNNMADRCSLISEYISDTLKPFVLNSISRLDECSQEICNGNGECTLLDAAKPINCKAPLQKSRYTCVCHEGYMGPNCQYYVEYIPTYSLSMITSTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z551</accession>
    <name>A0A914Z551_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z551"/>
    <dbReference type="WBParaSite" id="PSU_v2.g538.t1">
        <property type="protein sequence ID" value="PSU_v2.g538.t1"/>
        <property type="gene ID" value="PSU_v2.g538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g538.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7527" checksum="7449A17D0BA49626" modified="2023-02-22" version="1">MKSPTPGRQYAIPQVPKSVQRREQNFSGGKPSKHDKAKLMRSEGIIPIQAGSNKYASQRGMTGFGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5E9</accession>
    <name>A0A914Z5E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5E9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7187.t1">
        <property type="protein sequence ID" value="PSU_v2.g7187.t1"/>
        <property type="gene ID" value="PSU_v2.g7187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7187.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26523" checksum="3613A91AD2B63DA3" modified="2023-02-22" version="1">MDMILLIMQQSKIYVIVATKNVLIILHQLIHSFWIPQIRWWNLLLILFQDRDLLNNLDADGNLFDEDNICNTVVDKGDPQYYYLYNQTSCCTSFSLATTAPNSPPCKAFKSRTTIYNPDFSIFATAFLNLTLNNGQLSTVGGYTFNNGSAQLRYYDGYNNICDTYGNSQLKCTIGVSTDRDHRYFIAAEFVTNSDVFPIADVASFLRDCLPENLKISYMGGTHHLRFQLFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9D9</accession>
    <name>A0A914Z9D9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9D9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g929.t1">
        <property type="protein sequence ID" value="PSU_v2.g929.t1"/>
        <property type="gene ID" value="PSU_v2.g929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051084">
        <property type="entry name" value="H+-coupled_symporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528">
        <property type="entry name" value="ALPHA-KETOGLUTARATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43528:SF3">
        <property type="entry name" value="CITRATE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g929.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8790" checksum="3147A70ED122A2D7" modified="2023-02-22" version="1">MTGAASLVAIPEMMPIALRATGVSLIYAIGATLFGGTTQFVITWLIDIFGAVAPAYYVVATSIISLIAMFMMPETRNFDVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAN9</accession>
    <name>A0A914ZAN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotidyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAN9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8831.t1">
        <property type="protein sequence ID" value="PSU_v2.g8831.t1"/>
        <property type="gene ID" value="PSU_v2.g8831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="267"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8831.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="44649" checksum="F7747F3D6579D546" modified="2023-02-22" version="1">MSVKSVILVGGAQKGTRFRPLSLQSPKPLFPIAGVPLIEHHIDQLCQLPNLTEIYLLGFYPAEEFTNFIKDCKSKFNVPIQYLEESGSLGTAGGLLKFENILLQNNPKGIFVLNADVCGDLPVAEMVVELDSQPHAQCLILTTEATREQSINFGSVVVDENGKVLHYVDKPTTFVSTHISCGIYLLRPEIWKVLSKEIRNGGIVQSLWFESDIFPKMASIGSLHAFHTTRWWSQTKTAAAALYANRHYLRLYRERHPERLCSKGAKIEGDVFIDPSATVHPTAVLGPNVSIGGGVRIGAGVRIRESIVLPDCILEEHSCILHSVIGWRSTVGTWARVEGTPIAPNPNIPFAKLDNKPLFNADGRLNPSLTILGSDVHVSNEQIILNSVVLPYKDLSASYKNQIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB32</accession>
    <name>A0A914ZB32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB32"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9866.t1">
        <property type="protein sequence ID" value="PSU_v2.g9866.t1"/>
        <property type="gene ID" value="PSU_v2.g9866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="111"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9866.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26041" checksum="A6A62A2820B3F48A" modified="2023-02-22" version="1">MSGNLSSPNYPFNYDNNLDCYYHITVPDGYIVKLTVLDFATEGEYSYFDYVQIYDGPDDQAFLLHKIGGTKVPIGFVYESTQRYMTIKFHTDFTGVRTGWLFNFIASTPNATAYFNATLGTISSPNYPSFYPNSFLQFYKIVVPETKIVLVEVMDFVTEPSYDYLRIIDGNNATDISHTLGLLSGNLTGNGSMPMTFYSTQSIVSLLFYTDHSVNRTGWTLNFRTAPKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBI4</accession>
    <name>A0A914ZBI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9289.t1">
        <property type="protein sequence ID" value="PSU_v2.g9289.t1"/>
        <property type="gene ID" value="PSU_v2.g9289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9289.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17120" checksum="838409B5D3DE92D9" modified="2023-02-22" version="1">MKYSKILFGNLNKIHWDRRPWQVGYRGNLIPQQKATGRPDVAVSSANVAILRHQMAREYEVMRHLANPYITEEKEAPYIRQKGNFSEQLANAKKLQEHKRMPGDPKKLKEDGTVYKPYGNYGNLLHKHRSVEDSMFQLIRREKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCP7</accession>
    <name>A0A914ZCP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9706.t1">
        <property type="protein sequence ID" value="PSU_v2.g9706.t1"/>
        <property type="gene ID" value="PSU_v2.g9706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9706.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="12882" checksum="854D33FD8AAB3DA1" modified="2023-02-22" version="1">MIVVVGPGVVVVMEPVYGVVGIGVVVGVHVIPQSVISLEAICDETVSTVLASVISGIRKLYPAPEDKLAKFVRDAFPIPIVIILDPLVFKFSQNPWESETSESRLAIITIVFSTGAGRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCY4</accession>
    <name>A0A914ZCY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8117.t1">
        <property type="protein sequence ID" value="PSU_v2.g8117.t1"/>
        <property type="gene ID" value="PSU_v2.g8117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF34">
        <property type="entry name" value="RETINOL DEHYDROGENASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8117.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35769" checksum="0DA0F1C4B5DE0033" modified="2023-02-22" version="1">MFWVYLILAFPVYYGLRYLWELIPVGNIKKRAVFISGCDTGFGRLLALKCTENGIPTFAGCYTKQGEENLKGDAKGFPGRLVTFPLDITKDESVEEAAKYVKKNLASDEMLWAVVNNAGVFSCYGPDAWTGIQDYKDAFEINCIGHIRCVHVRSRVSVPCGAPYAASKYAAEAWMDAIRQELRPYGIICCILEPEAFKTNLVDENAMIQRVNKAWSKLSEETKIAYGEDYKDYFVMKWNSFFHKTATPHLHYVVDNYYHAITAKFPRYRYRCGWLALCFYIPLTYLPTGLQDYIFNKAAGKVNLPDDLRNKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDM5</accession>
    <name>A0A914ZDM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9783.t1">
        <property type="protein sequence ID" value="PSU_v2.g9783.t1"/>
        <property type="gene ID" value="PSU_v2.g9783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9783.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21614" checksum="78910C236784A033" modified="2023-02-22" version="1">MGHHRRTDDLALVVGRRDVGDLFHRGDHCLLEGRLRVLAVVHQVEAIGNQAWLERLAITRRQRRAELAFVAVGGFVQVDVQYKLALVRRDQLDDSGRFAGRAIGAEVAVRVDRIEVPAVDALEAPRIHARRHQQVGLAGIVGGVLFEELQRAHHAAGLIAVHATGDQRSRQRGSSRDCAGRTGCRSRRRTRDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZH26</accession>
    <name>A0A914ZH26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZH26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9584.t1">
        <property type="protein sequence ID" value="PSU_v2.g9584.t1"/>
        <property type="gene ID" value="PSU_v2.g9584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14692">
        <property type="entry name" value="bZIP_ATF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9584.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27840" checksum="6949C92B49C82C23" modified="2023-02-22" version="1">MYETNTCFNPCYHQQVGMTYPHDQDLCDHVPDIEGTPYGREYSFVPDFLTNNSQNYNSYYKQNDNESNGNFNQCYLSNYEAPSETMLPISNNCTTNCSQYVISEEDRDPVKRIFDEISAECEHLLLKKNCEECRTKPNENYQYVDLQDNSSTTNKSTTTIPTEIFVADEETAQLALSMKRKREQNKMAAARYREKRKHINKSTKAEIGLLEKQNLALKTTVKDYQKEINALRKKLGLPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHS8</accession>
    <name>A0A914ZHS8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFU1 iron-sulfur cluster scaffold homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZHS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g986.t1">
        <property type="protein sequence ID" value="PSU_v2.g986.t1"/>
        <property type="gene ID" value="PSU_v2.g986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g986.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20242" checksum="59AF4B8DE856E94B" modified="2023-02-22" version="1">MFIQTEATPNPATLKFLPGKVVMPEGTADFRDAESASNTSPLAAKLFAVPGVNGVFFGYDFITVSKDGAEWQHLKPAILGTIMEHMMSGAPVMATEQAKGHDHTEGEFFADSDAEIVETIKELIETRVRPAVAQDGGDITFRGFEHGVVYLHMKGACAGCPSSTATLKHGIQNLLKHFVPEVLQVEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS48</accession>
    <name>A0A914XS48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Clc family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XS48"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10810.t1">
        <property type="protein sequence ID" value="PSU_v2.g10810.t1"/>
        <property type="gene ID" value="PSU_v2.g10810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000042">
        <property type="entry name" value="Clc-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10810.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17208" checksum="6146B8DBF8811903" modified="2023-02-22" version="1">MGLLNFATRLAKAQAVTFILVGIADLIAFISVLTPAWQTAYDTDAHQRVDSGLWIYCPGEQACWYIFSDNMMNYYEKVDVCRFLLIGDCRKKLLKTPYFFGWHYACLIIMTITLALCTIGLIALAISYFRPHKRKIATIVMDICLGFACKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSY9</accession>
    <name>A0A914XSY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10387.t1">
        <property type="protein sequence ID" value="PSU_v2.g10387.t1"/>
        <property type="gene ID" value="PSU_v2.g10387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10387.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10413" checksum="984EA9BB339A79D6" modified="2023-02-22" version="1">MSIENDSDYLNSNEIALIICIAIVTAALSVGAIFFIAECFVPEFLTYWQDEKKAKDMIKPQASKEMIAELTAKRDKNRSKNQKKKNLKDGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT08</accession>
    <name>A0A914XT08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11100.t1">
        <property type="protein sequence ID" value="PSU_v2.g11100.t1"/>
        <property type="gene ID" value="PSU_v2.g11100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11100.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25584" checksum="9AECA7F2449C4F45" modified="2023-02-22" version="1">MDIIIYSKRLDAETVTFFRDLLPENIKENVGDYDLRPGAEWDSTDIDRSISRCPKNNFYKAFDFFSYKLAISTPGEPNACGEAFTYILADRSPDIQDVEQPMDAHMDIDSDETDGNSSPQQKRQKIMEAIDRDVQEIDDLTPSSSINFEPDEHRRIHNFYKTLEKNFINTCESMASQILSNLQQKQDISTCFAEEKNVSHGKIKHIGTKLRKNYFVQHLATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT53</accession>
    <name>A0A914XT53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XT53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11143.t1">
        <property type="protein sequence ID" value="PSU_v2.g11143.t1"/>
        <property type="gene ID" value="PSU_v2.g11143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000011">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF161">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11143.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17226" checksum="F14C4FA1BEEA5847" modified="2023-02-22" version="1">MQGPNEEFMKVAVAEAIKGVNEGDGGPFGAVVVKDGKIVAKGHNMVIGNHDATAHAEVTAIRNACDALGTHDLSGCQLYTSCYPCPMCMGACLWARLNAIYFAATSTDAANADFDDSHFHEFVKNPITNEGRIWEQLKIDAYLAPFDEWKRKSDKVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTR7</accession>
    <name>A0A914XTR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTR7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10659.t1">
        <property type="protein sequence ID" value="PSU_v2.g10659.t1"/>
        <property type="gene ID" value="PSU_v2.g10659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10659.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8813" checksum="88432C5163C10609" modified="2023-02-22" version="1">MPIKRIPLTLQQQMNLIDKSVMEDVSDDNEEEDTQDLHDLEMSKVFEKVTNGTIDDIKYESDESILDGIKFLLQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTY3</accession>
    <name>A0A914XTY3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyruvate kinase</fullName>
            <ecNumber evidence="4">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914XTY3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10433.t1">
        <property type="protein sequence ID" value="PSU_v2.g10433.t1"/>
        <property type="gene ID" value="PSU_v2.g10433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="13">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10433.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18048" checksum="9174A705879AD801" modified="2023-02-22" version="1">MIGNGMNIARMNFSHGSHEYHGETIANVREAASKLTGGKTVAIALDTKGPEIRTGLLTGGSSAEIELVKDKSIRLTTDPNVETSCTAVNLYVDYKNITKVVSKGSRVFIDDGLISLIVDEIHEDFLNCIVENGGMLGSRKGVNLPGTPVDLPAVSERDMKDLKFGVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUG6</accession>
    <name>A0A914XUG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUG6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10610.t1">
        <property type="protein sequence ID" value="PSU_v2.g10610.t1"/>
        <property type="gene ID" value="PSU_v2.g10610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037709327" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10610.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17159" checksum="62E0F69AB90EF844" modified="2023-02-22" version="1">MKNSFVFFFFCCSFNCINGSICKSYNSSTEIFTGGINLDLAYEFTDKSFILTITNFTSASKINATVESYSADTQTQTCEVESSSPYKKCVLKLSKYFAYDISVNFEPYLHLQSVITTIIYNGTEVINPSVSAQTPCMDTYTHQHLTWFCCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUL3</accession>
    <name>A0A914XUL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUL3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10657.t1">
        <property type="protein sequence ID" value="PSU_v2.g10657.t1"/>
        <property type="gene ID" value="PSU_v2.g10657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="12"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10657.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30744" checksum="7C759947039C52F6" modified="2023-02-22" version="1">MWFDINRFHAFVLITWQFGIFFASQQIFPIFSNYVPKWRCFPEEEFSKNCTIYKECEGEIEFEYIYFHSTALEFDWICGWNSYWAAFYSQLQFIGVLIGTFTCGSLSDWKGRKPIAIAAMTLGITCSIISAFAWNYQVLLITRFFIGLAIGGTLVVVCTFVMEMILPQQRMALRAFFNWGVARLIMTLICYYFNDWRTASIACALFAAPAILILIFVMPESPTWLHYKGNLEEMRKSEEKVARFAGIHYIEEQHSAVVEKQSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW02</accession>
    <name>A0A914XW02_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XW02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10706.t1">
        <property type="protein sequence ID" value="PSU_v2.g10706.t1"/>
        <property type="gene ID" value="PSU_v2.g10706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="80"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10706.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20279" checksum="C27A148AEE4B0D4F" modified="2023-02-22" version="1">MTSVNSKAWESLVDRLKSLKSFRLHTGNINNYVELKTKRFKSSSEELVACLDMQFSNLNENVKVSDNGTLLLSAKDAPLTHDRDDLKITLKVFLNEFSINEVDSAIVAILDELKVDSIEQLIIDFPHSGDDEVDNVWLEKVTTVWKELEKLVQNGKVISIGVADFNLKAMKMLMDKADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWA9</accession>
    <name>A0A914XWA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11243.t1">
        <property type="protein sequence ID" value="PSU_v2.g11243.t1"/>
        <property type="gene ID" value="PSU_v2.g11243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11243.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16742" checksum="4CEE1D0D6DAAC481" modified="2023-02-22" version="1">MLNVIEQIHQLGFIHCRIRPHTFITGLKPRERYMLFIINFSLARMANPTRAETIISRTPPQIFDRYAPRCQHFGLPYHRRDDLESWFYICCDLFHPHFLPWSSDKRLKSQQMAELKEKLMKGELFHRYAMENFQIIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWK3</accession>
    <name>A0A914XWK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10148.t1">
        <property type="protein sequence ID" value="PSU_v2.g10148.t1"/>
        <property type="gene ID" value="PSU_v2.g10148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038024288" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10148.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9917" checksum="38DE44739F6D5A66" modified="2023-02-22" version="1">MNSKLFILFVFFAIVSCILAFNIDESADVSDGHEDPNNLIPNLFSRSKRAVRRKCRTNVPGCRQNMCDTCCGKCDGFFCVSFMCLACCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWW5</accession>
    <name>A0A914XWW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWW5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12440.t1">
        <property type="protein sequence ID" value="PSU_v2.g12440.t1"/>
        <property type="gene ID" value="PSU_v2.g12440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000058">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF124">
        <property type="entry name" value="FI05614P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12440.t1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35968" checksum="262072672FFE9DD5" modified="2023-02-22" version="1">MGHRPYPGTALAFIRDDDNVIFTDRQYDNHDLTELRDVLNRVPDIALVIYGSSAWNGFHTFFLPNNAAFAKVVDRNRIDREVLLAHVSGMNRVLFTWPWLYDGGLHYYPSIRFSSNIIEDNFKLKLTVRNITDHRTGRWDLYAVSEVYERYSFFRRGAVWAKILVPNIPVQNGVVHIVDNVLGIVSNTIDMLLMDNYRTTTLMRYINTIGQLVRNYFSATGGLVTFFAPWNEAFERIPEPIERRLLRDRIWLEQILKLHIVPAKELTTDEMTNETIVSTVDNRRMLYFQKGEWPKNNISKFYSFKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY58</accession>
    <name>A0A914XY58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XY58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11890.t1">
        <property type="protein sequence ID" value="PSU_v2.g11890.t1"/>
        <property type="gene ID" value="PSU_v2.g11890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF189">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Patched" evidence="7">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11890.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="56144" checksum="4EF5A50801BAAEFD" modified="2023-02-22" version="1">MYDTISNDVTFQGPNNTILTFQNICEPFCGINEMLIKGVTTPSFLVDRYYPIFKIIVYDVNIGKFIFKRTEDDKGRLTASKLMVFYYTTFVDSEEKKMQLDELDQKVVKLIKAHNDNPNNTIDIVLHGTFPVQKEVERGFEETTPLILLGVILGLICFTVTTALSAQLFRQLGCQTFLWAFCGILISIFSIAASFGSICLIGFSINTVIAMTPFIAISFILNAIVLYQINDIWHRLSSGLTKRTQHVINEAAEFGKNINNGHLPLTQKNSFIYRVTKPERLAYLFFYCPVIIMTCQCAPTETLKESAVKNRANPECFSRKIKRTFTNSFIVPYSKFLQTSLGKIIFVSIFTIGFLWPASYGVRKIKNEMDFKKILPQNSASLQAFEFMEEHVWKDFLQFVFIVNKPPNFTDEKEYLPFREMVSEIEQIKEAYGPKSNMMWLIDYLNHEFDINYHKNFSMKSINMTRFIPFISQEPYNAWNDGLKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZQ6</accession>
    <name>A0A914XZQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13444.t1">
        <property type="protein sequence ID" value="PSU_v2.g13444.t1"/>
        <property type="gene ID" value="PSU_v2.g13444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF6">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13444.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8361" checksum="40DC3CC18BE3715C" modified="2023-02-22" version="1">MRKQGVAVKGKFLCGLHPALANSTKVRIVDIDTGPDPDDTLDEKFVDASGGYSLNGYTRELTNIDPGKILFLLNLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0R4</accession>
    <name>A0A914Y0R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0R4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13046.t1">
        <property type="protein sequence ID" value="PSU_v2.g13046.t1"/>
        <property type="gene ID" value="PSU_v2.g13046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13046.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12166" checksum="196CEE0CF48C3E67" modified="2023-02-22" version="1">MEESDDGSSSECASPAPPKRRRESIMSTNGGLNYSKLNELKIKATKIVKQLTHLTATDTVSQLRILCEKLTISDQISILLCAEEVLQRLRRNAIHSAVVNFRRKLQTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1X8</accession>
    <name>A0A914Y1X8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyl-accepting transducer domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1X8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12784.t1">
        <property type="protein sequence ID" value="PSU_v2.g12784.t1"/>
        <property type="gene ID" value="PSU_v2.g12784"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="44"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12784.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="32664" checksum="43DE4924AF5892CF" modified="2023-02-22" version="1">MNYGQYKEDAHNYGLSYIHHILAEELTADDPHNTTFLYEISVADIKKASKAAKDASIELKKKEKVVQDIQQKAKESQKAAQDAKAAVAKAQEDAKTAKKAAEDAKAKGEQGKEAAQKAQDDVKKAQKDAEDAKQKADQAAVEAQKAAKDAKQAADDVKAAADDAKIKADAAKAQADEAIKDGEEAAEDVKEAAEDAKKTANEVQAEATAAKDSADKTVADVEATAKDVETTAKDVESTSKDVVATADEAIKITGEVLGILEEVGDGAKDAADKVGDGAKDAADKVGDLFSGVTEKSGYGIALFLAILGYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y248</accession>
    <name>A0A914Y248_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y248"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13531.t1">
        <property type="protein sequence ID" value="PSU_v2.g13531.t1"/>
        <property type="gene ID" value="PSU_v2.g13531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13531.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30319" checksum="A1D5B85F1768FFA7" modified="2023-02-22" version="1">MKSKDYMDAPGELDMLIGFFLMNSVCIVFFLMFGMCVICSCMRRKPNFMKSSEKEQPSNVVAPLKRRLLSPKSVSPKPSSTTAPLLPVTNPTFKPTFKAMISKAMKNEDFQKMAKVNNNSSSNNNTDQQQQRRCSVTSPIFNETTHLLRRASERPLKEETQIDIESQNGIRCHSVTRQVQIQIEPTDIPSDKESPPIEITPPPTALSNPVYICPTCHPTSPPEANHICDCNCENEAPQTEPAEETDEEATGASVIRQNLLGPLSFDDLYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2H7</accession>
    <name>A0A914Y2H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2H7"/>
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        <property type="protein sequence ID" value="PSU_v2.g12986.t1"/>
        <property type="gene ID" value="PSU_v2.g12986"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="149"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12986.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33114" checksum="9F7F12676A2B031F" modified="2023-02-22" version="1">MLWNPDDLKSFLDRHTKDENAKIVVITSGGTAVPLEKNCVRYIENFSNGTRGAISAEKFLENGYLVIFFHRANSLQPYSHRFPDLFNRLNVDSDNKFTVTDYPNLGEMLEKKHKYTDRILMLPFNTFDDYKNDLEYICHACAGYKKRLCVYLAAAVSDFYIDAEQLPEHKIQSADGGLNLKLTIAPKVLRRIVKDFVPEAFVVSFKLETDPSVLVQKSNKAIKEYGHQIVIANMLKTRKRRVTFIRANEDPYPIDLDSPEFSEKVDVEIEELIIERIKKLHSSYSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3J5</accession>
    <name>A0A914Y3J5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3J5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12331.t1">
        <property type="protein sequence ID" value="PSU_v2.g12331.t1"/>
        <property type="gene ID" value="PSU_v2.g12331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12331.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13173" checksum="4265449B7B458019" modified="2023-02-22" version="1">MLNISRSGAVYVRDRAAELGLIRNRPFPKRVFLDTEVNESITQILRKNRSTKAKELRVMLAKRGHTLSISQIRYRIGALGFRWRKMKRVQMPVPFGNLKIMISGIIYLWMNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4M7</accession>
    <name>A0A914Y4M7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4M7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15150.t1">
        <property type="protein sequence ID" value="PSU_v2.g15150.t1"/>
        <property type="gene ID" value="PSU_v2.g15150"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15150.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17274" checksum="BE97BD14592B0E3F" modified="2023-02-22" version="1">MTSGPTVAATTGSSTAPHHHHHHQQQSSQHRRTLTTTSATGAAGAPTGFIPIQLRSDATPKQPRKRYRPPTPAANSMGTLQDKPLQLETVALLSIFPTNSIEATAAQFLGPQKRPPKKFSKDFKGVSSLFFMGGKTVVDILVCVLPYLRISSKQNSKKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5C6</accession>
    <name>A0A914Y5C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5C6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14445.t1">
        <property type="protein sequence ID" value="PSU_v2.g14445.t1"/>
        <property type="gene ID" value="PSU_v2.g14445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14445.t1"/>
        </source>
    </evidence>
    <sequence length="593" mass="64974" checksum="BDF843F7DDA0DD71" modified="2023-02-22" version="1">MYSSNPIHHQLQQSSQQQLQQQQQQSFQQPLSQHHHPGGISASSAAAAAAASGTSYPPPAYNHHHQQQQQHHLQQQQLQHQQQHQEGYHHVNGSTPAATIPPIPSTNGSGNNQKILSKLLTAAPRATGGGGRGGRQNHAAAAAAAQQQIQSDIPRHQMSAAASGTMPNGNLPANEMRGTTNMQIQRAQILEQQQRMYMYQQQQQNSQNGYMNGQHHPSQSQMMANPQHYQQHLQQQRQLQAQRAQQQQIFHSQNNSQEYSVMNGGGPSTSYSNQSSKKSNNNNTQIPSTNNSNIATGAAAGTAGGGGVQQGGQQSQQQMLQNPQQQQSAMMHHASNNGSSTPVQPRPQQQQFLNGQQHPQQQGINSTTMQGQQGSRSQQQQYPQTLQQQQQSLHQQQQPQQAMPGQLGRPPYSHQHPQTQTSNLNIPSHIQRQQSMQGPSSQQQQQTMQFQRTASDLQNTNPNSTSSPFTSSLPSLPPPTASSTSSSAQQQLQQQQHPYQTSLPPPSTSSSSQQQQQQQQQSYQPPSLLSNGQLSVTNSALLTNGQLAVATINQGSIIQSNSNAKKAQFQRQLGLLLHARKCRQRDLAQCGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5H0</accession>
    <name>A0A914Y5H0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y5H0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12933.t1">
        <property type="protein sequence ID" value="PSU_v2.g12933.t1"/>
        <property type="gene ID" value="PSU_v2.g12933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="9">
        <location>
            <begin position="47"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12933.t1"/>
        </source>
    </evidence>
    <sequence length="402" mass="47269" checksum="C0AAD812072D5585" modified="2023-02-22" version="1">MFSYHRYKHSILPFNQLFSRAYATKPLLQWPLDSEIKLSNSLHEIESYWNDKLANKPIGNVAKDAEKKYILSMFPYPSGMLHMGHMRVYSISDVLNRYYKLNGYNVIHPIGWDAFGLPAENAAIQRGIDPKEWTMSNAAAMKQQLLSTGVQFDWERELYTCDPKFYKWTQWIFLKLFDQDLVHRTVDEVNWDPIDRTVLAEEQIDGHGCSWRSGAKVQKRKLAQWMIETPKYAKRLSEGLDKLRKNWKEVADIQENWIGKCDVWRFVFKLKDGRTERDFERFDLRIRDPKKLATAQFIVVKRDHALVRELPVLPKETTVLDPTVYNFVNDKHMHIVVLSEELEARDNEKEIEYFVNARLGEDFDEEIMKLLGLKPKGTSNDVSAEQVVELAQVRFSFFSFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y681</accession>
    <name>A0A914Y681_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y681"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14271.t1">
        <property type="protein sequence ID" value="PSU_v2.g14271.t1"/>
        <property type="gene ID" value="PSU_v2.g14271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14271.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14350" checksum="237471DB7B644D94" modified="2023-02-22" version="1">MHLGLAKAKTNRMRQATIGEGDLSDSELLRREVETDVADAIAKDAKKQSPRKRAKSSATESDLASTQDDSPSAAVGARRRSQRLKSKGPAVEEGILLPGSNQETGVTKEALKLLEKKRDTDQALERLKALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6F8</accession>
    <name>A0A914Y6F8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6F8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15035.t1">
        <property type="protein sequence ID" value="PSU_v2.g15035.t1"/>
        <property type="gene ID" value="PSU_v2.g15035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15035.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="24855" checksum="377FC5135B1B21D2" modified="2023-02-22" version="1">MAISAAKWTHQPKDAFSLSNVCIQSGLPKLSETDALKSMSAQKFDHIHRILPFLKPQSEDCLYMNLFVPERLDRHKTQFGGPQLSVLLLIHGDDYGWGSGNAHNATILSASGQIIVVTLNYRLGVYGFMGRCEQSSCNGNSGLSDVVAALKMLSNILPSFGGDPTSITLMGWGSGASLVSLLMASPITQPKNRLFRRAILLDGTALAPWAMSMHPQQYFMKIAETLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6P7</accession>
    <name>A0A914Y6P7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6P7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15875.t1">
        <property type="protein sequence ID" value="PSU_v2.g15875.t1"/>
        <property type="gene ID" value="PSU_v2.g15875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="351"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="612"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15875.t1"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112949" checksum="079339F0E765AE7A" modified="2023-02-22" version="1">MDRRRDFNSSGGRDRDNYGGGRRDYNGGGGYRSSRSGSSDSGNSANSNYSYSSREGGGGYRGGRGRGGGRGGGFGAPGGRSGADDSTTTKLPSREPELFSIPELGQLPPIPPRKEMIVRTNGYEIDTKNAKVAFQYDIRWTGENKKGKTFDMNSQTKDDVKLQHKQTALFSVFYTLIHSNKEFFGTIQGDEQFSYDCGSMFFTQTKLLKDDEHRTFDIEIDDFKQEAKDYYRQIVKASAEISFTREIRPDLLNGELENDRPAIQYLELVFSQAQRLSGNYLSFGNKFYEKKSSEEIDRTPLILKEGVTRSIRIIGDPADKKLMVQMVPTKTTFYDSRSVKSLIEHAIGGARLEDIFRGNKLKLGSNAIKNLCLRTTHLERNRNFIAYGLTSESAERITFELDGKKLSVADYFLQKYNIRLRYPQYPCVIQKRGKEDKNYFPIEVLRIPENQRVPKAKQGNDLNALIIRKCQMLPADNVEKIEKNREDAEILNSNGFIKNTGARVEPRQLVTAPARQLLTPSIVFKDTQKTLNCGVFGMQTNDKFVQPAAVRKLACVLASNQIDSRRAEDFVNNFLRRLELYGVRIDKHDLFDWSNPDRDSERLLDIVKQDYDFAFIIGDTDQLHHGMKHMELSTKMPTQHVRTRTVLKANNTLFDNLAFKFNLKAGGVNWALTSDPGLVTQLQNRDLLKSLMQNTLFFGIDLSHPLARADPNLKVENVDPSCVGFASNIFKGHANMAKGDFGYQDPQQHIVNAELLEAKFTAAINAYFRNSGQYPSWIVVYRAGLSEAEIQKIQSEEVPVLKSAIEKMKAQSAEFNSSAVRLTVIMSNEMSNFRLFKDQIDKRDKAPMQNVPSGTCVSERIVSRRVPSFLLVAQRALIGTARPAVFHILEGADAVPLEHVRYVTYCLCFSHGIVASPTKLPGPLVSAADLSKRARNNFRQHKYQGIEDTQSVGSGDAARYRQGQGDILTEDEKQAIRSRENAYFDDLNQALKAAIEDGRFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6Z8</accession>
    <name>A0A914Y6Z8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6Z8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15042.t1">
        <property type="protein sequence ID" value="PSU_v2.g15042.t1"/>
        <property type="gene ID" value="PSU_v2.g15042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019960">
        <property type="entry name" value="T1SS_VCA0849"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03661">
        <property type="entry name" value="T1SS_VCA0849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00313">
        <property type="entry name" value="CABNDNGRPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="beta-Roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15042.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="33785" checksum="5AE8EE6A8292A0EA" modified="2023-02-22" version="1">MLKAAVTEGGRPGSSGTITTKPVGEGQYRFEFLVDDRSSSSNYKVYIDDVTLLSSGNPQDWTEVNKVDIVNTKEDLDAALKGGSVTNDPAPVGNDHIIGGDGNDIIFGDTINTDGDVLPWHEVGGRPDNLPDGSGLKALEVFLQMKNGGTPATGNDLYEYIKENHADFNVDGDKRGGNDILDGGAGNDILYGQGGNDILIGGAGDDIMFGGEGDDTFVWNKGDEGTSSKPAVDYVMDFGDSGTDTLDITDLLSGHDVNDGNLSQYLTVGSSDNGKMEIGISSQGNGQVDQKIILDNIDFDAEKAAQIANSLKDGTLKSSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y702</accession>
    <name>A0A914Y702_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y702"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15047.t1">
        <property type="protein sequence ID" value="PSU_v2.g15047.t1"/>
        <property type="gene ID" value="PSU_v2.g15047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15047.t1"/>
        </source>
    </evidence>
    <sequence length="762" mass="85958" checksum="2750256C228E0B72" modified="2023-02-22" version="1">MVGRRYRDVLDASDTIRRLTEIASDLGNNMKEIRKISKNLLAGDDSKHSIKKETLFKFGLLLRLEDLLENPNDPLGDVFTFLFTENLHRGVSIESQSFKIENVDINLILRPLGDRLITFRLALCDRLEHHLGEQTDWEEVSGILAALAFLNQSNLQDLLEIYLKARKNFITKSLESSTTLISVIEMIKSTAECVDDVFGKGRAIISALDFVTSSGWCPEPINVAIADCQFCYLKQLKIEVTRINSSYTKSYAEGLSDVFVGDKCTKWIEGLCEAVKSRVKGMCDFFEHAHDVIEFIYAINDIFSTEWPTVSSNSLVYQKLFGSSLIERYKALITKEMHYIEAQLLSNASKVQTNPPPLFQKRGARFDSLLASGVSQELYEVIQKSFNRLSDLLSNTNRYISMGKEENVQELLPALAEAALEMTKRIATLPKFNSETSGSENLTAEKNKWLSRFRIYLALVQHEPSVLCQCMGRNTELIIQCNKLLHSAAENALCNFMNILIDESYLESKIPRMSHYVSDPMKFLDLAQQLEKYKLPNSESIIEIPTQLSRFYFSFLFSICQKTNTYSVGHLFTRNVTSHVSKVLGELLSKSLIETASACSAVSVICTQILFDCKSLFFMFLDKGFVEAASIIENKLDPFNKAVLTEPLSKNAKIFVQRTSMLFGQLQIEPSTSSKDIELAPSFTSLIDIAPIIPNIPRLPLIPGMSVIEHQEERKSVVAEEIKPKKKAQPTATPTDVLGGLLGARPDIKNLYDKFSTNWFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y737</accession>
    <name>A0A914Y737_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA topoisomerase type IA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y737"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15084.t1">
        <property type="protein sequence ID" value="PSU_v2.g15084.t1"/>
        <property type="gene ID" value="PSU_v2.g15084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785:SF1">
        <property type="entry name" value="DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="DNA TOPOISOMERASE, TYPE IA, CORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topo IA-type catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15084.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21088" checksum="62F7B2369AC82833" modified="2023-02-22" version="1">MDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7V9</accession>
    <name>A0A914Y7V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7V9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1536.t1">
        <property type="protein sequence ID" value="PSU_v2.g1536.t1"/>
        <property type="gene ID" value="PSU_v2.g1536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1536.t1"/>
        </source>
    </evidence>
    <sequence length="594" mass="66815" checksum="F8BAA8D924CEC858" modified="2023-02-22" version="1">MVKCEKRFKNFKLAAVKGELDENNDRKESLAAAADGINKESGGIAEGDTEFPSTGIDLKIDKLQSSSLNAVAAHENGGGGEAEANNLTEDLGTDGKKAKAKKVEEVLINEISRDRWRRHPPFSGTRRLSLRDPLELALTFSKSPIFVDTIDLCNTVNSLDLSNMKITKLDGIEQMLNLTCITDNQFIGLIFCGRLQAFPKLMVLDLSNNPISESDDYRKKVLQRCPALLVIDCEIVPKDERSMVIRKQGKALTIDFIEKAFPNFEILKILNLRGNDFQMIALDRSAVSKLQQLTEIDLSENLLENLYELIDLQNLEILNLSKNSIITLTGTPILPALSELNLSHNNLTHQMISRMGLNLLTNLKKLILSGNHINKFDMILFDLPRLVELDLSNNEIKSIRKKALPQLNWLNLADNKMKDLEGLATPCLEFLDISNNRIVTCSALKSISQMYKLKKLNCQGNPVIERRVYHEFVKTQVKTLEILDNEAMVRNISDATPASSSDQLYRRLSTVQPKSLPNGSNNGNNINNGITIRDQNTFESNVNVKWQNQQQSSNLKEPIFQQGKRPIYLPPRSNLVVNQRINKALSYKNFFPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8P4</accession>
    <name>A0A914Y8P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8P4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15120.t1">
        <property type="protein sequence ID" value="PSU_v2.g15120.t1"/>
        <property type="gene ID" value="PSU_v2.g15120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15120.t1"/>
        </source>
    </evidence>
    <sequence length="759" mass="86864" checksum="2A0A66B4D66D9D33" modified="2023-02-22" version="1">MTTDVEMPLVAPTPPPPSVPRHEGRTQFGFRVPGPEKKPVIPLEEVSLKPIALQFLKLRKNVHNLLQTCSEDSVNGEMVDTIKELKTTLKGFKMEFKKLPKINDIREEQQHRIAELLKQIQVKDEFLSKLIGPPLIKDEGKLADASILIEEKPQTSEENMKDGEKKKKQKKDKAKVKSGSKNKSKDKDGKRKRKGKGKRKGKTTKKSETSTATSKTHKDLKEMQPKKFKLKVAEKISTSKLKKKPIEKRLVDPAKIKKLKEKIAEDKRKRAEISNPIAKIIPENLPTQKIIGPLPKPSAPSKSDMKEKQKVVKHQTQQSSTKITKLQPELPQISLFPQKDDQPPKDQLQKEKPTPPQNELSKDKLDDKNTPNNETQPSNDEVQPVEKIETQIPADPPSPPIVKIMPLPGKKLRKPEPPIKAVVTFGRPKILAKKNPPKNLEEPLKSVLKKPEGVGEEPKLPLEENKNTEEQEKDEKEKAKAEPAKESKPRTWKDLRQIFKKGNAAKSDKPDQVKKKANTSKKPNVKLSKQYKLRKALKKLAKIQNQQEKQKSEEKKKLEEKKKNAPTERMNIFKYFKDEKAEKKALRMAAMNASKKSKTVKKVVRKPISRSEKILRKIRRNAINNAQRDGCYTSPLLTIKYITELQNMIKNAENNGIALSSADFRRLRYKYFSCKGTELYEEKLSNGNKKAISKHDIEKLRKINFVKEQNDIDQQNVNITYQKNIPRTVTDISMRLPRKEFGNGELDQTIYAELRKMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8W1</accession>
    <name>A0A914Y8W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8W1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15890.t1">
        <property type="protein sequence ID" value="PSU_v2.g15890.t1"/>
        <property type="gene ID" value="PSU_v2.g15890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037378724" evidence="2">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15890.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22649" checksum="58C59489E21B4158" modified="2023-02-22" version="1">MDCATLCLISAAVSFVPTSDVQKCNYCLDVRGITPTCNEDIMGCAQTYPDMVLYCLTVNAIHFDTHVSRAVRCRSHKAYNVSLSWTEEIMGLEKCSFGTSKICNCSTCPLREETRIPQIFQHPTNFQTKPQNSLSNNGNKNHALPNRLQISAVNQNQTFLLTKGMAENIRGIGNIYNKATLKFSFFQFYFFVFAAIIIIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9D8</accession>
    <name>A0A914Y9D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9D8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15377.t1">
        <property type="protein sequence ID" value="PSU_v2.g15377.t1"/>
        <property type="gene ID" value="PSU_v2.g15377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15377.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14802" checksum="064C387DF69F58BB" modified="2023-02-22" version="1">MPSFYKTNLMDGYDSLLIPPEKDDATFVINVNDANVEENTKSEKTVKKLAKDYPYKRVLKGSREIHAIALLIWYIFEFLLVPHLDVSNEKLIQEEILKPCIFTNAIQLNNLLKIELNNFATQTFVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9E3</accession>
    <name>A0A914Y9E3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9E3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15384.t1">
        <property type="protein sequence ID" value="PSU_v2.g15384.t1"/>
        <property type="gene ID" value="PSU_v2.g15384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="61"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15384.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29187" checksum="F2121B7A25CDE519" modified="2023-02-22" version="1">MSRPEQKRLNREYLKYFPQSSSVFGKLKKVFGNKNDKIPEYINTNNTPCDENQHVIPASNIQLCKELGIGEFGSVWLSSWTQSNGDIIQVAVKRVPPEKLIANPTSFLQEAAIMTKMRHEFVTRLYGVVLDTKSVMLVSELAPCGSLLECCQKPALRTSFPVDVLCTFSIQISKGMQYLASERLIHRDLAARNVLVFSAEKVKISDFGLSRSLGIGEDYYRSEFSPTMRLPIAWCAPESINFLRFTEKSDIWSFAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9Z1</accession>
    <name>A0A914Y9Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9Z1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14344.t1">
        <property type="protein sequence ID" value="PSU_v2.g14344.t1"/>
        <property type="gene ID" value="PSU_v2.g14344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14344.t1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44141" checksum="61B8EF9F34CEDD0C" modified="2023-02-22" version="1">MTPLKETDLHDSETSHLMITHGITHLLKFHEKKWTKKTLIKSTAITGAGIAQLVGGLGVGFGGALSGVGAVPGAIAAKVLLFEGISDILFGVKGFATGFSDNSYVKHKLIGLGMNAVMWMAPALLNIKKAEEKNIQSQNASEFAIKEIYKEIEKNVDRIFESSEIIKELQRMMQQILILYEDFVFIFDDIFEQFIAPNLYEICYFLVEKLRISIFENGEIEKGKNFEERISKILKSNEFFTFIKKFNEYLCKFVKQLQKSLSKKFMKFKAANNILEEQFVTETDSLDAEIKAKEMIENGMLDLKGKIMAALKEGIKVPLNYDIEEEYSKQLNFIIKNAYSELRNCAKINNEKESDGIETTDATVEATQKRSKVSIKAEEMDVEIFYDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAB8</accession>
    <name>A0A914YAB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16225.t1">
        <property type="protein sequence ID" value="PSU_v2.g16225.t1"/>
        <property type="gene ID" value="PSU_v2.g16225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16225.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11579" checksum="0828017ADD7DEB18" modified="2023-02-22" version="1">MPRGDKSAYTDKQKRQAEHIEESERERGASEGTAERIAWATVNKQDGGGKRSGSVRKVRYKEGHTQDGSEEGGGKEGTGSQDSHKEGHKEGDKEDGGQEDQHSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAW7</accession>
    <name>A0A914YAW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAW7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14633.t1">
        <property type="protein sequence ID" value="PSU_v2.g14633.t1"/>
        <property type="gene ID" value="PSU_v2.g14633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14633.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17970" checksum="AC152EE9A22166C9" modified="2023-02-22" version="1">MQVSKIVQEICRRFLSLPAMDISDKMFYQSRLKIVNGLLSVIKNILNGNYLPIALFYSYNDQTYCNLLNTVFKVFTRYALYSEKYPKCSTLYNDTIYELGRVYPVFVSKMKLEDLSVFFHYLEMGFHANERSKLLNSCTTFERITDSRMENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAZ7</accession>
    <name>A0A914YAZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16465.t1">
        <property type="protein sequence ID" value="PSU_v2.g16465.t1"/>
        <property type="gene ID" value="PSU_v2.g16465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16465.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="14580" checksum="5EAE194575A99C05" modified="2023-02-22" version="1">MRKSGAEMNFPSLGKRKSNDDEGVASIFGGSAKTPSINKPGKITIKIGGTSSQGSSSSSSDAPMNEEVADAPIKTILNPRYRKSSLVTYDSSDSDSDEEGDNKNNIKSKSAPASVSVSPVSQSPPKKKIKVLHYSPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB33</accession>
    <name>A0A914YB33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB33"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16498.t1">
        <property type="protein sequence ID" value="PSU_v2.g16498.t1"/>
        <property type="gene ID" value="PSU_v2.g16498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="YheA/YmcA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16498.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19527" checksum="19DA48AC387F3B26" modified="2023-02-22" version="1">MYNEDLDIYFERDEGMNDTHHSWWDSLPDPLWYTVGKASIDVHCYWFATCHRAHRDLVVQVPKTRRHNFKDTDNLDIFPHLPRMMKHIKKYQPYRQQLVLLRYNGVANALRMFGEENDAINEALSNADVLIRKIQEEMDSNELFETTNLMIYQKLNMLLIPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC07</accession>
    <name>A0A914YC07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16963.t1">
        <property type="protein sequence ID" value="PSU_v2.g16963.t1"/>
        <property type="gene ID" value="PSU_v2.g16963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16963.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19101" checksum="164B002502283017" modified="2023-02-22" version="1">MNIIIPSVLIVMISWVSFWLNREASPARVGLGVTTVLTITTVITTTNNSMPKVSYIKGLDVFLNFCFVMVFASLVEYAVVSYMNKKLGQRREKKRKRAEAMPQTTEFPMFTNYAPISPNQNTTYNYRAPGLPSSSPSGGGGGGALNANTTLPANAMTPDCDCSFFNSGGCLKYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCU5</accession>
    <name>A0A914YCU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17107.t1">
        <property type="protein sequence ID" value="PSU_v2.g17107.t1"/>
        <property type="gene ID" value="PSU_v2.g17107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17107.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27484" checksum="5B0B3E67699D005A" modified="2023-02-22" version="1">MSNTCVTVQLLPRQKIILIHKYNVQTYEESVASIHHDINENIPEFFLKLRSVHDLRDVKAISFMFIDAANFSSFMDAYNFRKKCQSFCKKNGIFYHFTTAATIKNSSALSSTKTMVNEDEQIAILEITSAGEVAGTMVIRGKYCYDVYQILSPKEPVFTQEWKRLFFGISNPKKVILLKEMNNVVTENLYEQLEELFKGVTPVIVVDWKDHCETFRRVTAEHAQHSLLKWISCYAFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCX1</accession>
    <name>A0A914YCX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15309.t1">
        <property type="protein sequence ID" value="PSU_v2.g15309.t1"/>
        <property type="gene ID" value="PSU_v2.g15309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15309.t1"/>
        </source>
    </evidence>
    <sequence length="400" mass="47364" checksum="57945F6F14B65C9F" modified="2023-02-22" version="1">MHSLIESNEGEHWVVTAMALMVNKDEASYDIIFNSIKKRWGELGVKPTFERVHADYEEAQSNALKTAFGEDKINGCLFHFDQCLLRYIGERGLYPYYNQKKTGKDTPESHRRIRTWIRSLMALPLLPKYDCQELAKILCRPPPKPENVSENEWPTVALQEVADYVNNEWVSRKDHMWNFNNLRRVRNTNRCEGFHSALGKMLDKKPKLKLFLKDMQLLCTEIEAEIEGIQQNRQKAYRSKKYAWLDERLKFYEDLFQKDISEAKTTTEKNFVRFRHCRRVSYLLHEIRNKSCNTVKSEKKHKPETLKVWKTDLNYIFDKDEDYGSWIEWMEKEEDLMISRGELEDDLDDIVEESFSFEMDEKDFNDADLSVLLASPPLKSSKKIIVKTVNFHTLAQFFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCY7</accession>
    <name>A0A914YCY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15323.t1">
        <property type="protein sequence ID" value="PSU_v2.g15323.t1"/>
        <property type="gene ID" value="PSU_v2.g15323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15323.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25227" checksum="821EF5475B2A0206" modified="2023-02-22" version="1">MYFNKFFLNKSFAAEEQFTAFQDPMYGDFGLRDSKDRVCLFLKFKAKIYNFNLNGTDIALELADLSDTSVSLNGFCALTNEVTKHSFIEARWKQNFRKKALKLTFVEKYEELRQSSLLQLRWQLTKVVYEEIYDNYQPFVLELLPAIDMQPMNIVNGFGSNIYLCDRTRSRTLSESFQSQMTIVSGIVLGLSSVGTLIGYSLRRLFLPARQQIYNSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCZ0</accession>
    <name>A0A914YCZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1716.t1">
        <property type="protein sequence ID" value="PSU_v2.g1716.t1"/>
        <property type="gene ID" value="PSU_v2.g1716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1716.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16940" checksum="F5142BD5321403BA" modified="2023-02-22" version="1">MNPSLCPTSSTSCGYFSFPLSQSKYNRNSTEVYECVDSSILLSAEEDYDDRDTNPYYQICNHQPQCMVLNASVLNKQFLNYLVRAHGIRLDSLRTEEVLFCCSLSHSNLARLVKSKLNKLQTISKWFKAGKLATKVSNVFISIFEKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE69</accession>
    <name>A0A914YE69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RCK C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YE69"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17589.t1">
        <property type="protein sequence ID" value="PSU_v2.g17589.t1"/>
        <property type="gene ID" value="PSU_v2.g17589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1450:FF:000003">
        <property type="entry name" value="Putative transport protein YbjL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="entry name" value="Regulator of K+ conductance, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050144">
        <property type="entry name" value="AAE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006512">
        <property type="entry name" value="YidE_YbjL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01625">
        <property type="entry name" value="YidE_YbjL_dupl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30445">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER SUBUNIT KHTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30445:SF10">
        <property type="entry name" value="TRANSPORT PROTEIN YBJL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06826">
        <property type="entry name" value="Asp-Al_Ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="TrkA C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="9">
        <location>
            <begin position="83"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17589.t1"/>
        </source>
    </evidence>
    <sequence length="415" mass="44264" checksum="792ABDA2FACB58AB" modified="2023-02-22" version="1">MVGSALVIALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHSGMESRQLSLALDNLSLGYALTYLIGLTSAQQIARERGLDTDANRKVYLPVIRAYRVGPELVAWTDGKNLRELGIYRQTGCYIERIRRNGILANPDGDAVLQMGDEIALVGYPDAHARLDPSFRKRLAQLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKTIADRIGFISIHSQVTDLLAFCAFFVIGLMIGMITFQFSTFSFGMGNAAGLLFAGIMLGFMRANHPTFGYIPQGALSMVKEFGLMVFMAGVGLSAGSGINNGLGAIGGQMLIAGLIVSLVPVVICFLFGAYVLRMNRALLFGAMMGARTCAPAMEIISDTARSNIPALGYAGTYAIANVLLTLAGTIIVMVWPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEZ0</accession>
    <name>A0A914YEZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15950.t1">
        <property type="protein sequence ID" value="PSU_v2.g15950.t1"/>
        <property type="gene ID" value="PSU_v2.g15950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15950.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20311" checksum="2B43D99AFEF5B28A" modified="2023-02-22" version="1">MRADGIRNPMVRYFNRDRNSPPFVVMMDSTNLKCIHMATDLTFDGTFQYAPNNMPNSQIYTMHATYHQLPNFNNNFLVGIAFVQNKDIPTYEQIFNVIKEQLIAEFGDIGCHKTIHMDHEIAAITAARRVFPDWTMHSCYFHFGKNLRTKMGQVLLDTEEVGKWFSALCGNYQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGA0</accession>
    <name>A0A914YGA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18473.t1">
        <property type="protein sequence ID" value="PSU_v2.g18473.t1"/>
        <property type="gene ID" value="PSU_v2.g18473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18473.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11690" checksum="3E42432804F0F2A9" modified="2023-02-22" version="1">MDDNAGTSDLSSFKVVLLGEGAVGKSSVLLRYIENKFNNKHLSTTQASFATRKLNIDGKDVELNIWDTAGQEKYHSLGPIYYRGSQGAILIYDITDERSFERVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGF1</accession>
    <name>A0A914YGF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGF1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17858.t1">
        <property type="protein sequence ID" value="PSU_v2.g17858.t1"/>
        <property type="gene ID" value="PSU_v2.g17858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17858.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28057" checksum="BC71AB9760DC63A0" modified="2023-02-22" version="1">MVNAVNQEKKQQDGEVGHVREDDEKLNVDRRPNRGDRGNRRPYRGGAGRGGGGRSDRTGVHDAPKKDGYGKGNWGTEKDELQGETEPTGETNVVKPTEEDNAEKNDSGVELEKEEEKPVGMTLQEWKEKNKAIEPETFNVRKPNDDKKLNLAPLKKSEDENKENDEFVVLRREPREKHVDISVNFASTTDRGVGGNRDGFRGRGGDRQDRERGDRQTRATKGGQRGDRNRGSNNSQFNLLNDQFPVLGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGH3</accession>
    <name>A0A914YGH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19403.t1">
        <property type="protein sequence ID" value="PSU_v2.g19403.t1"/>
        <property type="gene ID" value="PSU_v2.g19403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19403.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11443" checksum="21575CB5CC2B8361" modified="2023-02-22" version="1">MFIAAPFLGKYMHVIGAKRMFSFGIFFTGITAIAFGFLNLLPPGRTFFWASLGIRCAEALGDAAFVTSSFVISAKCFPGRIATIVGIMETFAGLGYTAGPVIGGVLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGJ9</accession>
    <name>A0A914YGJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGJ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16464.t1">
        <property type="protein sequence ID" value="PSU_v2.g16464.t1"/>
        <property type="gene ID" value="PSU_v2.g16464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16464.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24507" checksum="778533BD59813E81" modified="2023-02-22" version="1">MAGGGVVTLPIAMLAAGETAGTIGIIIIAISFCYTAHLLGENWNTMCRKWPVYRDHCRKPYPEMAYRSMGRGARYFTSLVLNLMLYGVAMVYLSLSAKIMNDIVTGVFNVHIGTCLMIPILALLLFPVTLLKSPADFQWAVVTAMVTTTLSVILIFYGTATDKESCEKEVSYPPFSSTSFLLSLGTFMFGFGGHGVFPTIQHDMKEPRYFTRSSILAFTSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGM5</accession>
    <name>A0A914YGM5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="4">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YGM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19461.t1">
        <property type="protein sequence ID" value="PSU_v2.g19461.t1"/>
        <property type="gene ID" value="PSU_v2.g19461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0274">FAD</keyword>
    <keyword evidence="1 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19461.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9791" checksum="25C00D65D930D798" modified="2023-02-22" version="1">MDHDLFGLRPNHRFFEQHPTVNDALANLLASGMITVTEDVETFEEKAVIVKGGRRFACNELILGTGYTFSFPFLKPSNLIPIKVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH55</accession>
    <name>A0A914YH55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate--cysteine ligase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH55"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19647.t1">
        <property type="protein sequence ID" value="PSU_v2.g19647.t1"/>
        <property type="gene ID" value="PSU_v2.g19647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19647.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8681" checksum="15E6891233696D7E" modified="2023-02-22" version="1">MRQFVQDHSKYEKDSHVGDEIIYDLLKIMDEISRGEKHCPKLLGEFRSKTDHRIPSAVRRAEEALAVASSKRKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIF6</accession>
    <name>A0A914YIF6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIF6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17093.t1">
        <property type="protein sequence ID" value="PSU_v2.g17093.t1"/>
        <property type="gene ID" value="PSU_v2.g17093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Prp18" evidence="8">
        <location>
            <begin position="73"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17093.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26542" checksum="F7065BDB401387CA" modified="2023-02-22" version="1">MQIGWKNEYQQALNRAQEEVLDEIVHGSYGKKEKKNEFFVEPTDEFWKSIKERAIKLGLNDNIKEDCFIIYDFLVFILSKWQNDLESRSLDEKTSPKGKLRTGHFQQTMKDVEPLLRALAKGNVNSDQRCHLVNIARIILIDHNYIIANNAYMELAIGNAPWPVGVTRSGIHQRPGSAKAYVNQIAHILNNETQRKYIHGLKRLMSKCQDYYPADPSKCFEFVKKDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIQ6</accession>
    <name>A0A914YIQ6_9BILA</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19394.t1">
        <property type="protein sequence ID" value="PSU_v2.g19394.t1"/>
        <property type="gene ID" value="PSU_v2.g19394"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039311">
        <property type="entry name" value="FAM187A/B"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19394.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30720" checksum="989B82506BA30FFC" modified="2023-02-22" version="1">MDSTSDWELVIPEYGKSTASPSEKAKRVVQSFLNRGNSTKEEIGNHFEIDIFNSQHFKHSGFYRCLRITSKNKIEYVEKRIEQLYFVDIFTSIYVIVREATDEEEEGTEKNLSSLPQFSSSTDLIEAKWFIHKWGECNRCGKNVLGEQRRKIECVIEPKNGTTVTQLANSDVSFLTMFENVPCLSSLLPLKYRSKFQNIKNFEEFRSCQSLCLLPNNETRTVKDIDDSGKEFVADELPPNEFSVFERLPPLRSSVIRKTVRVCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJH0</accession>
    <name>A0A914YJH0_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJH0"/>
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        <property type="protein sequence ID" value="PSU_v2.g17460.t1"/>
        <property type="gene ID" value="PSU_v2.g17460"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17460.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19694" checksum="275F9C4FEE7E0881" modified="2023-02-22" version="1">MKTQLTNSAKIQTNKTEKLKQKLLNSMAKVDKIQLQLKRRLKKICEERSEMKHKLDQMKAIVDGFEGELQETEVEMSSLKTDLTFSNIPDESSENSELMERFYNAQKAFEDRKASCLQKKAIKEQQMSELKAVEMKIRELQKRKTDTVKVIPQRNQSDFTLNQSAWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJJ5</accession>
    <name>A0A914YJJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJJ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1949.t1">
        <property type="protein sequence ID" value="PSU_v2.g1949.t1"/>
        <property type="gene ID" value="PSU_v2.g1949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1949.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17736" checksum="101C468E6852E70E" modified="2023-02-22" version="1">MSITDSKKPFSPNPPLKFDRATSQDESAEIKEDDEKHMGFSIVDILNAAKPKIVVRDNEDPPDEKPCNLSFLKPDSPQIERRHASPAKSPFTNDFQNMAAGALEQNQWLCSMMGAGMPINSWMSWFNAERLQGSILEQLRQQQSQADITHLKQKKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJQ0</accession>
    <name>A0A914YJQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DM13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJQ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17534.t1">
        <property type="protein sequence ID" value="PSU_v2.g17534.t1"/>
        <property type="gene ID" value="PSU_v2.g17534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF16">
        <property type="entry name" value="KNICKKOPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037816499" evidence="3">
        <location>
            <begin position="25"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="4">
        <location>
            <begin position="724"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17534.t1"/>
        </source>
    </evidence>
    <sequence length="858" mass="95082" checksum="7339014536ACF80E" modified="2023-02-22" version="1">MNKLLHYCFGLLIFYNSILIRANAVAPINPAFTAPSSGQRHSSMVLPWSAYREKLEKEKLKSGNDPNKPVTLLLKPPFKDVFQRKSLNDKTLLETQRNTIIAHKPTTLPTNQVTVSNHAPPSTIKFPPSSRPAGFSYSTNTFREQLSNNNRTYSPISRPPTTLTSNPQPFHHHHRDAAGIPLSQITIPHRTPIIPTINQVAAPTQFGNLAPASPFPLSNFGPQPENIANSIFSQSQLRYAPQTMPSFGQISPQAPNFGSELYGGPPPAAATGGNAISENAFGNLNPFQFLSNARDSPVEQIARIAKNLLSHENQELFGNLLGAAKASSQSLTSNAVKKGVEFGSSSAIEPAATLISSSASKDNKEIERDAKLHLTQKDLENAIKGATTDEEKNLLELAVKDIAATNDTSTTLKPHTPEINLPKIVKTENELQTWINQNRPKNTSKEVSVLKKIFNAQDLPYYGRYCGVFAENFNSSRNYEIGGALWVVDNRHFIVSKFHFKPISGSDNITFWAGPKIVTGNNAKDFLPSKNGFHLKPVPIDIQTFIVKDVKVFNATIRHSIPINASIAEAEDDSRNKRDLFSHHYEENIPFKVSANFGNQKTIKSESSSDGNKDFFENSTATITTKDISVDSATTNLPTTTSGKITTSTTHTAITVSNGFNQKDIVPLEWYAGFQPMLLTLPEDQEVKTTHWVSIYDHNRQEPVSFILIPNGNAFQIPSTVQLRPFVASGSYKLKSGPIHIKDTKTIEISEFSLQTQGIPVWFMIGKEVVPNSNGHIVPVFDKVKNKFDCMSLRDYHNETVILRLPGVLDIRDVFWFSIFSIPQSLSMSHIYLPYNDMHLPPDLDGRSSPICEWSPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJS9</accession>
    <name>A0A914YJS9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17563.t1">
        <property type="protein sequence ID" value="PSU_v2.g17563.t1"/>
        <property type="gene ID" value="PSU_v2.g17563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17563.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14339" checksum="46880F703E8DAEC3" modified="2023-02-22" version="1">MTFYSASTKPVALTAQRPWTTLNDPAVDDLLQDCQERFCTFENASIFISTFNVNGKSPPEYTNDWLNFDTERMPDFIVIGLQEMDLALGTYVTESTIREEQWLRALKRSLPKIYHVVRQLLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJY3</accession>
    <name>A0A914YJY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Death domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJY3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20655.t1">
        <property type="protein sequence ID" value="PSU_v2.g20655.t1"/>
        <property type="gene ID" value="PSU_v2.g20655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20655.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18579" checksum="A972B26252119EB0" modified="2023-02-22" version="1">MSITYVFELPTRVVLDLGMILDSGDVWEDVAITMPDITDIDINDCRRLRDNRTESRSTEALLRIWGSKGYTINDLYKVFARLKMIRCMKIIKEYVEPDLHMLETDCLSLPDVITSPKGNSTDGSSFVKPSTHHIHPSVSVYSKKTEGSSWSSLGDVETYVFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNK0</accession>
    <name>A0A914YNK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNK0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20543.t1">
        <property type="protein sequence ID" value="PSU_v2.g20543.t1"/>
        <property type="gene ID" value="PSU_v2.g20543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20543.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14686" checksum="F945623EAFC2F5A5" modified="2023-02-22" version="1">MQDDCNDHFPELLTTNEVPEYIKILNGKRAVLDLPALDENDYLDNDDNDDEEKENENKTPVSQIVLPVHESFDIIYFLRFVKHFNEKTEENQLGIQFYRPLFDDFLNFIDDKITTEMYDDEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPH8</accession>
    <name>A0A914YPH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21536.t1">
        <property type="protein sequence ID" value="PSU_v2.g21536.t1"/>
        <property type="gene ID" value="PSU_v2.g21536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="224"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21536.t1"/>
        </source>
    </evidence>
    <sequence length="673" mass="76657" checksum="E0C81B33A0A79220" modified="2023-02-22" version="1">MEENQEIERQQEEAEEELFEPRIQPLDPDIVKQIAAGEVIHQPWNVVKELIENSLDAKSNHIVIALKDGGFKEVMIRDNGCGIHPDDTEQIAHRFHSSKIKSVDDVYKIQTLGFRGEALSSMALIGEITILSKRNGIEDGIRVVIHGKERTKQVEHNLETGTTIVVINIFKTYSPSDIRRSTYKITKLVTDYAYANPGIKFVLHTPTIAFRTPPLDTSNQKEWISAILGTKKLFNKEISSTNPPFSVSIFGIHLKEGKLTLKTPKTNLTCFVNRRLVTIHLLEGLLRDQLERNAFTCETIIAFFEMDPSLIDVHVSPTKELVTIRNSEAVLDTVAEAFGDMVKIRYRESEVEGGKSPKTLFSSISNESSVSNNFSPAKKIRFDPNQSLMDSFVENNDTADYESETPSIIDPDNNMEHGQNEERGEQFIFRHVETIYDSLLDEIRIDCDPEWTTKFRRAQSTKLCKIHDIFVLMFQNESDFYFISFRVLLQEFFYQRLLIGFSNFCCVKDLNDIKISLRTLLQSALPEINEEFIQAKFKILKTSKIALDDYFSITFEETEDENDLILTGVPVLLPCLSTPWSNIALALIALPETYPNNPELNIIWIKDVAKRFSAAFAAPLFRCINTGKESFTLEFWNSQVIPTIKTTYLCGSQFVNSVVSGSNTDLYKSFDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPL8</accession>
    <name>A0A914YPL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPL8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g214.t1">
        <property type="protein sequence ID" value="PSU_v2.g214.t1"/>
        <property type="gene ID" value="PSU_v2.g214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g214.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8295" checksum="11076BF7977E46C0" modified="2023-02-22" version="1">MSDDVPSPPDPNTGLIPAPILPPERFVSDDTAEVFEFDVEVEEELSTLYEMAFPEAATFADNAEDIDFIYPSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSV1</accession>
    <name>A0A914YSV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3082.t1">
        <property type="protein sequence ID" value="PSU_v2.g3082.t1"/>
        <property type="gene ID" value="PSU_v2.g3082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053105">
        <property type="entry name" value="Class_V-like_SAM-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="54"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3082.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27461" checksum="C01933E7BDBBC772" modified="2023-02-22" version="1">MEKCDFGKKKELNRIVVDPMSIDFYQEFYVECGMHCGCQGKCRRRIFPGSHAAKKLHVEYFLNKGFGVVVDQPVAAGMPVCEYRGLVCIRETDLIQPSHYQQDLLYDNDGNFYVVDAVNDGSVARFINHSCSANLVQINVYSSIPSQKKIPPPPRVALVACRDILAGTELTFNYGVAYFHDRHLRCFCYELCCLIPADDWALKTKNERETTQEINYAKRHIETHFDETKDVEPECIDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTF7</accession>
    <name>A0A914YTF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2955.t1">
        <property type="protein sequence ID" value="PSU_v2.g2955.t1"/>
        <property type="gene ID" value="PSU_v2.g2955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF211">
        <property type="entry name" value="LD43457P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="68"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="260"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2955.t1"/>
        </source>
    </evidence>
    <sequence length="522" mass="58355" checksum="3D925B6B891FBC19" modified="2023-02-22" version="1">MRQIEVLHEFQHCSSASISENITTPIATGAITASSSPPQSTIGIGNRTSSIDSGMTGHATTSSGGSGKVNYVIEELKTTEESYVRELREIIEYYIKPFDAPENYSQFPPQLRGQSKGIFGNIQTLYKFHERLSHCFNSTDSIVEICHLIIDRRRDFLSLYRPYCQNKPISEAIRNEHHIESMKFFIDCQQRAGHLLPLSSYLLKPIQRVTKYQLLLKELLRYSPDDVRKDVTAALAAMLDLLSQLNADLNQLHISAFAGDLHLLGPLRLQTECFVYSFKRKTHRVSNKPQRRFLFLFDGGVLFCKKRTQPLPYAPEYYEHKMCIPMKDLGFSESSRSESERFDIWDGTKSDGYAVQPIEEAAKVKWIQRLSKLTSALGHYHNKPDQQSVSSSNHSHNHSTSSSSRPQSWTSDGTVSSRGSGGYDDMSASSSSHTQGTDFTLVDPNGNPSSAPVRRQSSSATSTYSDVDNRYGSSHVTTIQIAPKHPSNHGLDSVALPPPDSSNYSLNAILESHPSQNELIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTP0</accession>
    <name>A0A914YTP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTP0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20813.t1">
        <property type="protein sequence ID" value="PSU_v2.g20813.t1"/>
        <property type="gene ID" value="PSU_v2.g20813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase NYN" evidence="1">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20813.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="34401" checksum="1A174EDED8B36A71" modified="2023-02-22" version="1">MYNGFFYQGITPSLPDAIEKLPRLIIIDGFNIMHHFKTLDYRNSVLCDDSMCPIILIPLLLKWAQEGFSVRVVLRNMPDENKITHSYILHELERMGLLLYGLTDDIEADDLLMLKLAKKYGALIITRDQFRNHKGCEKVAEEYTVEYEQVRTNVTVEMLKKCLYYNSKVAIHDSKDRFYANQDDKDYELVKEAATKYPLCSPTIIHVLSLLQLYIYNSIRFMYNLGISKQVIFLQLNDKFPMEWGHFLQRYYDWQLIEDKKEKAKSRNEVIEEKREYIIDPEDCYLKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU53</accession>
    <name>A0A914YU53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20996.t1">
        <property type="protein sequence ID" value="PSU_v2.g20996.t1"/>
        <property type="gene ID" value="PSU_v2.g20996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20996.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14892" checksum="2041BD4A9E92DCFB" modified="2023-02-22" version="1">MLWNHFCKPSYCVSDLIKIMSMPPLVESIERDSLWQFKIVNDAENPVLLEFDTFEGDRKQASPTFLLAMFLRQQIKVIRAKINSKPIALGFCLLLDKYDGDEKKRIQNQLEEACRLLKIECVFVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU90</accession>
    <name>A0A914YU90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3556.t1">
        <property type="protein sequence ID" value="PSU_v2.g3556.t1"/>
        <property type="gene ID" value="PSU_v2.g3556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01862">
        <property type="entry name" value="16SrRNA_methyltr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013675">
        <property type="entry name" value="Mtase_sm_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023543">
        <property type="entry name" value="rRNA_ssu_MeTfrase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046977">
        <property type="entry name" value="RsmC/RlmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007023">
        <property type="entry name" value="PRK09489.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47816">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47816:SF4">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08468">
        <property type="entry name" value="MTS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase small" evidence="5">
        <location>
            <begin position="109"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3556.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30118" checksum="186BFA5D1FA67702" modified="2023-02-22" version="1">MGDNARFSLVATADDVADCDTLIYYWPKNKPEAQFQLMNLLSLLPVGTDIFVVGENRSGVRSAEQMLADYAPLNKVDSARRCGLYFGRLEKQPVFDAEKFWGEYSVDGLTVKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSVAFARHSPKIRLTLCDVSAPAVEASRATLAANGVEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPDVLDETFGFHEVIAQTGRFKVYRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUN0</accession>
    <name>A0A914YUN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUN0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4328.t1">
        <property type="protein sequence ID" value="PSU_v2.g4328.t1"/>
        <property type="gene ID" value="PSU_v2.g4328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4328.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10587" checksum="A72CDB95BFF1E85C" modified="2023-02-22" version="1">MEHFQHPPPLSSHSNEGISSEGRRLEAENDCLRARNTMLEAENARLKSEVGFNAKLSKIQEEFPQLLQAYQDAMESKIIKAAAEISSLKKTVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVC9</accession>
    <name>A0A914YVC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVC9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4099.t1">
        <property type="protein sequence ID" value="PSU_v2.g4099.t1"/>
        <property type="gene ID" value="PSU_v2.g4099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4099.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12667" checksum="B6083A84125C1AA9" modified="2023-02-22" version="1">MLKVPVNVFPIKFFLQQLHQIAFTEDLDNRILVGAQISIVQCSGLSNNNTVTLVEKSQTFSSCPIGVYKVRVDYSSNFTFTYNLMTSPISFTAVIQPIIKPHKQTILPQQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW01</accession>
    <name>A0A914YW01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4156.t1">
        <property type="protein sequence ID" value="PSU_v2.g4156.t1"/>
        <property type="gene ID" value="PSU_v2.g4156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16647">
        <property type="entry name" value="mRING-HC-C3HC5_NEU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46519">
        <property type="entry name" value="RING/U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46519:SF2">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4156.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32047" checksum="798A71660E0D7A73" modified="2023-02-22" version="1">MFMDTSVELWPFFDVFGRTKRIQLIKPQRLNTLSEESSDSRESSSEPPARPPPPRFSTDSVVSDLQPVERFNSAPSNVETSGRPLLNLSRTSDPPPTRESDVLSYILELRSSTPDSNPATDRSFSINDNTSFRRFNSQISQPTPERSPISDSYTTSNAASARLSNAENVLLRNLATLYTSPTTAGSAPQFLMPVIPPRSDESTSSFLSRHTASASPAISALPSSTSLTSREKTPNDSNSNECVICFSSAPNAAVYRCGHVCMCLGCARQLMGDQGKCPMCRQIITDVVQLFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWR8</accession>
    <name>A0A914YWR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAPGEF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWR8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g441.t1">
        <property type="protein sequence ID" value="PSU_v2.g441.t1"/>
        <property type="gene ID" value="PSU_v2.g441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01785">
        <property type="entry name" value="RA_PDZ-GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF249">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="371"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="490"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="754"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="863"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1141"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g441.t1"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134040" checksum="EE42FC72518255FD" modified="2023-02-22" version="1">MIAHQRAASVGPHTIQTQVNETPRPYHLNQTSSISIGTNNINSGPIVVSSSGIINNHHHQQQPMVHMRTNIPTSHKTMPPPPPPTMTNSTTNSPASTSSQPFTGNSEHDTTPAAATTTNVPMTHRFSKTRFQFARKNSDDAGTSAVKIRALSGNQTSISNVARRLRARSTASSSTTDGDDFSGLPEASVDSEDEDEESCPSHDSYQELKDNVRECLEKEPSERNSDDISILLDFMQQMPALACLPLSIKRQLCLKMVFAVVSDVGTVILQHGEKIDSWSVVVNGAVEHVKPNGERREYRLGDCFGAEPIPDAQYHDGEMRTLVEDCEFVLVEHSDYCTIMSTVSQHIEKESDGVTGEIVSEIERRLIGNQVGLVLIKAKPEKLLQHLIDEIDASSDAHFVEDFLLMYRVFISNPIEIMEKLLQWFNDGTLRDKISRILLLWVNNHFNDFESHKDMSNALENFESLLESKNMFSQQALLNITCSVKSRPRTVILTRSNRDQELAFNILGGKELNHGLFISYVEPGTVADKNGLKRGDEILEVNGHSYRHVTLQRALEILRESTHLSLTLKSNLMGFKEMLLQQDKMQQAAAAIVPSEDIPDDTPPEPRQPSYSHANGTVGRFQKKNVFINNGRRSTLNVLPTAGGGNAVRPSPLAPSSTTTWSMNSNGSGSSSGSTNHTKSSMFEKLFGMLKGSNGNSDNGSIDSTDEARGSHTLRTSRSNPDISGHLIKHSAQNSHLAGGNPFSGANALIEQAIKIYRSDQSFRYLTIFSNTTAKNVVQLALQEFGMGNEGSSTDWSLCECTVTKEGVNKQRRLPDDMQNLAERIGLNSRFYLKNNNRSENLIPDELAPEILKDSRISLQTLNAQYVATQLTLQDFAVFSSIEPTEYVDNLFQINSVYGWPQLSEFEYLFNREMWWVVTEVCGERNLSKRVKLIKKFIKISRHCRDIRNFNSMFAIVSGLEKPAVRRLAHSWERIPGKYLKMLNDVQQLMDPSRNMSKYRQHLASVAMDPPVVPIYPILRKDLIFSHEANPTYCDKLINFEKLRMIARIIRSIVQLSSVQYDVDILMQPGFSGDLTAATMRKAANLANSGTAKQASSHQKKKLYEQTLMLRKVKSYLGSLQVIESELELDRMSLECEPNPAGSSMMGSSSAAQQRRRGPSPSPSSLSSHSNQSDQKNQQRFAPKFGKHFGTFITPPPPYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX15</accession>
    <name>A0A914YX15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YX15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4504.t1">
        <property type="protein sequence ID" value="PSU_v2.g4504.t1"/>
        <property type="gene ID" value="PSU_v2.g4504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4504.t1"/>
        </source>
    </evidence>
    <sequence length="498" mass="53728" checksum="4792D6708C0648E8" modified="2023-02-22" version="1">MGMQKFVIPKNLTKALHFIGGTRINLGSYNPTFDVFEPRNGQVLATVEEGKRSDIEEAAQAALGAQEKWALVSPAERGMILRRVSDIIRHNVDDISVWEVRDNGKPISEAKADILSCADTFDYFSGVDLNGEHIPLADVDERFAYTRREPLGVVGCIGAWNFPMQTASWKIAPAIACGNAVVYKPSPLAPVSAVILAHILHHVGVPDGLLNVVQGGAHTGAAICQSRAISKVSFTGSVVTGKIIAQNAASDFVKPVTLELGGKSSCIIFEDSNIELAVTGAMMANFFSQGQVCSNASKVLVHKSILEPFTKALVERTSEMIIGDPLNESTRIGATISAEHLEKVKGYIDGAVEEGAHLIHGGNRAVVNGLPNGYFLEPCILSNITPQMKVYKDEIFGSVLLIIPFDTDEEALRIANDTTFGLAAGIFTNNLSKAHGFARKIRAGNVYINTFNDVSPYVPFGGYNQSGYGRENGKAAVEHYTQYKSIFVNASNKLENPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXR1</accession>
    <name>A0A914YXR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4746.t1">
        <property type="protein sequence ID" value="PSU_v2.g4746.t1"/>
        <property type="gene ID" value="PSU_v2.g4746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4746.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22135" checksum="F68B217D975C9548" modified="2023-02-22" version="1">MSNSILSDLINADDTSPPPSQLQTAAPQLSYAHAPPSSHPTQFTPHQSFQSQSSSQQSFQSQPSSQHQGFYPQSNIGPSPFYPPQYSQQQQFYSHYPQQQSFAPQQEPIEIDDEEEYEPESPIEPPKPRTELDIAINGLDGDDPLPATPLMICTDRLYQSFNNLILDFFPEPRLAVPPQGDIKESAEFNVKTVRLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXW5</accession>
    <name>A0A914YXW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXW5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4798.t1">
        <property type="protein sequence ID" value="PSU_v2.g4798.t1"/>
        <property type="gene ID" value="PSU_v2.g4798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4798.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18986" checksum="9CE7C1EC2CC50858" modified="2023-02-22" version="1">MTTDRHDLIASTLSWGFNRYYAKFGYNYHIGVSDAAKGFTNSVTFCKTECHYFYNYHEKNVYILRNKISQNGYQKCEYLEAFKDNEKASDWCDNNFGKNENVYGDLRDFANDITLHCNIYAISVVKTSLKYKDDFEEKMAFGTGVYEFPCFGQINVAISNYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYC8</accession>
    <name>A0A914YYC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RNA-binding protein NOB1</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5504.t1">
        <property type="protein sequence ID" value="PSU_v2.g5504.t1"/>
        <property type="gene ID" value="PSU_v2.g5504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="196"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5504.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38135" checksum="0DC4342F3B19A631" modified="2023-02-22" version="1">MRAAEDVPINHLVVDSGGFIKAAPLIDLGSKIYSIRDVVDELRDRQTRQRVEAYPFDIIYREPSSESVRAVIEVSKKTGDYASLSVTDLKVLALTHDLHVEHCGREDLVYDVEIKPPVWEDKPTTKIDSTTKVSTKPGFDTWLDESNIGEVLNRMESAVDPKTLKMEVACLTTDFALQNVLLHMKLNISSVAGMRVSRLRTFILRCRVCKKTTSIVTKKFCPNCGHDSLHKVGVSVDKHGNQKIHINWERERVKRGYVYSLPTPKGGKHANNIRVTEDHMLPQNRMAKVTQDPLSDAPFSTTDVTSRSALLGLRSYGRQMPRNPNEWQKGKKSSGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZR3</accession>
    <name>A0A914YZR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5114.t1">
        <property type="protein sequence ID" value="PSU_v2.g5114.t1"/>
        <property type="gene ID" value="PSU_v2.g5114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5114.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="39541" checksum="F027AC3916752FC3" modified="2023-02-22" version="1">MNKLISTRHSVRDLDTNDISVINSSTKFPIQSPQNRSSTPLPPQRVQSHHNLLNHGPATHNGNGASQNINVLFDDLRKCTTDVNEGFADVTTPTETITALVRQLDIKTNEVLGASVNLNLSARNQGILSAASAVQSEFENQLAAWTNYQNLLRNSGISTAKADSKISSQKLPSSLKSTSSNNIATVRQTYVTVDEEMYVSPNLDESVMTTNALRSYHLKKLRVECDAKSNAMDHAARTLQPVANFLAPQRPSVVRACAPPPPPPPLPQNFFKAPKVAINRPKESNALKNYQNVPDALIISSHDLVRSRLRCSYLPRSPCGTPFRNVPVSSAIDDALKQALEKRRKDLDESSGANDSSGKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z082</accession>
    <name>A0A914Z082_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z082"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5756.t1">
        <property type="protein sequence ID" value="PSU_v2.g5756.t1"/>
        <property type="gene ID" value="PSU_v2.g5756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5756.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18371" checksum="80B8AA934C7EDDF1" modified="2023-02-22" version="1">MISSILTSTAYCVMWWAGDVRDYWLVLTILEIFGVFINVYLTLVVCVFYSRMNRVLEHYEGKRKTTKNYNRFSPNVTSQEIDVNEALDEGEIGYRNQWDDPDRWYPDPKYPPPPPDPYFDAQPPYPPYGTPLKRPLGKYIYLLKKIYANLLTHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0B9</accession>
    <name>A0A914Z0B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0B9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6179.t1">
        <property type="protein sequence ID" value="PSU_v2.g6179.t1"/>
        <property type="gene ID" value="PSU_v2.g6179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6179.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9615" checksum="D9947553DA517E65" modified="2023-02-22" version="1">MDYCEDEKESDTVICAGGVNHGSTPGDSGGPLLVIRQHRWIQYGVSSIANEKPIPGDILSYSNQGIYTKVSSYCDWIEKTTSGEVKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1A8</accession>
    <name>A0A914Z1A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1A8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6145.t1">
        <property type="protein sequence ID" value="PSU_v2.g6145.t1"/>
        <property type="gene ID" value="PSU_v2.g6145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6145.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12898" checksum="B854612A29A825C4" modified="2023-02-22" version="1">MKLKEQQTLYTACTFFHRFYMVQSFKEHPLEIAALGCLFLAGKVEETPKKCRDIVNVAKEVLRDKYSSPTLLQDVFQFERTLLSTLGFDLNLDNPYTFLELLYVFSMNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2C1</accession>
    <name>A0A914Z2C1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z2C1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6508.t1">
        <property type="protein sequence ID" value="PSU_v2.g6508.t1"/>
        <property type="gene ID" value="PSU_v2.g6508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037250843" description="receptor protein-tyrosine kinase" evidence="19">
        <location>
            <begin position="24"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor L-domain" evidence="21">
        <location>
            <begin position="56"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Furin-like cysteine-rich" evidence="20">
        <location>
            <begin position="205"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor L-domain" evidence="21">
        <location>
            <begin position="370"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6508.t1"/>
        </source>
    </evidence>
    <sequence length="547" mass="62140" checksum="2E518E73A181858F" modified="2023-02-22" version="1">MRVSFLWHFVLITICALLLKVNAWEERHCFSIDLRNSPTQGFKHKSVKDGWDVFLECTILDGDLSISMMSMPGITDDQFPVFKHLREITGSMLVFNVNGLTNLGRMFPNLRVIGGQSLIMNYALVIYQNEDLKYLGLDKLTIIRNGGVRIMDNPKLCYTRFINWDNILIGKIRDVMVDQSGGGVMFTDTNQDTETCQDKFGCKVEHPEKCQKVDGVLSCWNATTCQTSCRHHKENNDTIGPGCSVTGEKCHASCIGGCEVPDDPGSCYACRDYELNGVCVDRCPSDMYEYMNNRCVTEAGCHLKLPVKSTLQDEKMLWKAFQGKCHYDCPGGYQEDPTNPRNCVICEDYCPKRCRGTTIDSIGEAMKYSECNIIDGNLDISIQIGGQVAKAEKFTEALGNIREITGYLSVRFWPALTSLHMFKSLEIIHGEQLYNNRYALAVFEMENLRQLFNTDIEQNIQIKNGLVSFQNNPKLCYNRIFQFITHVGLDKNVSDNDISKYSNGEKAICEEVPLHVEVTTVTNVFFVISWKKILIQQIWIKENFLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2F3</accession>
    <name>A0A914Z2F3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2F3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4428.t1">
        <property type="protein sequence ID" value="PSU_v2.g4428.t1"/>
        <property type="gene ID" value="PSU_v2.g4428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="12">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4428.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41909" checksum="E18DEAD3476AAA27" modified="2023-02-22" version="1">MPHFYFQITKASLKFERDKISLWFSVSYVFTFFTYLVTLAFVWIPLIFSYDTWNLEIKKSIAWLLPIIAIIASWLQCLHILRKSPCGPYIMMMARIFKSFFNLTIIWITTLICFAFSFQLVMRDSGTTPWDDPIIANSSSSIGMSMFQSFTKISAMMIGEVEANDILERRAWIANLLLIMFEIITVILLMNLMISLAVGDVSELRASAEEKLLRVKTNYCIEALHLSEKLDCCPGTPLYKKRINNIMIISKNDDSEFSTYLPLKDRAKFPVCSREEEKVHDVTLNAKGIRFFSSLISNNFDRQSILSVNNAVLRIVEANGSGVGSVEDEGFKNELTNMKDNESFVTKYKRWLIGLRWRAFLNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2P6</accession>
    <name>A0A914Z2P6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MPN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMC8/EMC9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2P6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6983.t1">
        <property type="protein sequence ID" value="PSU_v2.g6983.t1"/>
        <property type="gene ID" value="PSU_v2.g6983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6983.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21761" checksum="BE0C47B7A5BE739B" modified="2023-02-22" version="1">MTEVSTIAYTKIVLHAVKYPHSAVRGFLLGKRQGQNPPIVVDAIPALHGSLLNGPLEILLITLDTYCTEHKLQIVGIYFANERLNDTSFDDIFAKTGEKLHSVFPNPIILQVENSKLSLVPKNVCLKAFNYDNKSWKSSTCFLTNEETGLRTASRAIEEKVYREIVDFEVHLDDPNLDIFNPEITEKIRQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2Y7</accession>
    <name>A0A914Z2Y7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DOP1-like TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2Y7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6254.t1">
        <property type="protein sequence ID" value="PSU_v2.g6254.t1"/>
        <property type="gene ID" value="PSU_v2.g6254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOP1-like TPR" evidence="2">
        <location>
            <begin position="730"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6254.t1"/>
        </source>
    </evidence>
    <sequence length="924" mass="103947" checksum="E2860FD9E0941F22" modified="2023-02-22" version="1">MDIFMQSVKKIIAIKMVSFCLEHVQLDNHSDIRSLYLPKLLRTILSTITIHGCDSFTRDNLVALLSLSRKILTEINQSVVSVETGVVTVRDIVESEIPSKPAPFARSISAYVTKHKIEEQKLIESCFKTCYEMVQCVCEWYISGRDRDKTGVLCAASAFLKDFGDFPIYCYEERESDALCEHLTHSSSRLPKWVEQLLKVVDVESWKAGHVSDFDVRSRIVDLLIFLYIRSYILIDQHLALQGRESNDDYLKTTWASTKSTTTVLLKPMLSNADIKILDTSNIFQSVSKVLWHTLSLSEEAGEHQTSACLLHRLHSRNSVESSSDVESAIVTDLTSTDKSRCSEACRRFRKLWTLTRSSINENVYDGIPYKSFNKVIMVLLGTIADDSLNGRNSCLKTVATAWFIDCAKHGDLPRVFQMIGTMLLNPSTSRVSIQYMTIESRLTNETIKSMPSDINCLSLITANGRQAFQHVLHDAATAQDFTPLAPVDCTKNLGWINDLKKHIYIPPTTNDTFSDSLKVMPPTPAPIKSHKRTISDIPQFDEDNESLGEISVELNADPDVLDCIAFLVDTVCDALEDSDYINDRFKQAARDLNIADSSVDLPSVNKFFQTSGGSPTYQRPVQKDTSHYRRSLPAALPSSNQNGTDKQRDEQSKSLLIESGTVASRVPSQPPLRLPDNIKRVKCGHRRQDSLQESIFSTPTQDLRLFDPSELPKLTAPGDDKQPLLEEAQAHMLLYMESPHTVDLGRSEMIFRILSSLLRSNRGAALGKMMVHCMVFNNTSTSPQSAGGGVNQLVEYLNRHYKAIQGEDFWLKSDALAEGSKPRHCSYFELFSTISLHYLRSYFLNSPISPVSENDLTTSWDCKIAALDFFTDLLREVIVLINDIKSRELVNSILTIYRQTKLQRCLISFLLTAVPTPRTPTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2Z6</accession>
    <name>A0A914Z2Z6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2Z6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7073.t1">
        <property type="protein sequence ID" value="PSU_v2.g7073.t1"/>
        <property type="gene ID" value="PSU_v2.g7073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7073.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26637" checksum="120A6B29FECCCA2C" modified="2023-02-22" version="1">MQLNNLKNDFEQSNNLVNRQAAEIAELTKENFRLQNLTKATSSSSLGTSTKPEQPEPQNPEVQKAEPENQDLQKQLIASKETTAPSPIKSLSTPATTSSSPKKSASQKRSMSVNDDDTESELVYYLPGIYDESVPVLNDADLEERRQKKDLFASRKHKKHCCNRPGTYYSCWNMDKCKGSQFYHRFCASSFYPNHGDNYTLIESELKKSPWFCKICTGEQEAFEKPPSQKKHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3A4</accession>
    <name>A0A914Z3A4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3A4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7176.t1">
        <property type="protein sequence ID" value="PSU_v2.g7176.t1"/>
        <property type="gene ID" value="PSU_v2.g7176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="38"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7176.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15720" checksum="55EF4958511BA485" modified="2023-02-22" version="1">MTGQSVTDSQIDEMLDSKASDVFYRQLNPISVEGRMAIEDATNRHNEILQIEQSITELQEIFEDIFQLVHQQGELVNNIETHVSGAYEYTNTGNTQLKTAVKHKQSAMRKKLCVITIVIAILLILIIVAVILGVTLTGHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4G2</accession>
    <name>A0A914Z4G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4G2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6781.t1">
        <property type="protein sequence ID" value="PSU_v2.g6781.t1"/>
        <property type="gene ID" value="PSU_v2.g6781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6781.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15152" checksum="E184671FE5973BA8" modified="2023-02-22" version="1">MSTLLINLESIALLSLFHGLTFVWILIFQCAKKPPINDKKHPSRSEMKQPSSYSTNNSTAPPKPGLSEAGAGTSQVSGVPPGANSFAQQTGNQSTMPATSNMTQTQQSQAGTQQSQASKKPTTEDDGGYDNLNPSSKPIESVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4J8</accession>
    <name>A0A914Z4J8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4J8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7278.t1">
        <property type="protein sequence ID" value="PSU_v2.g7278.t1"/>
        <property type="gene ID" value="PSU_v2.g7278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7278.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24497" checksum="5A11C8C6B86E1B10" modified="2023-02-22" version="1">MSKTQKRGAGGPHNPSPYMRRFQLPSLTFKDSTDYDELLSPLETEAKQQLMDEKNSQLRNYFADSIGTSSNGISKMAQKEPHSHQQKEPHSSNGFRTTTTTKIDSESKLYEDPFEPHSIDFHLLRKKKLPESQSFEHKKSVSNVETTTTTNVPSKVVADVPPPIPPHRPNPRQKIVEIEKYRMCKEILELERRSREMMDKGHLWILIRDQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z511</accession>
    <name>A0A914Z511_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z511"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7056.t1">
        <property type="protein sequence ID" value="PSU_v2.g7056.t1"/>
        <property type="gene ID" value="PSU_v2.g7056"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7056.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="11734" checksum="B154B2EB70351220" modified="2023-02-22" version="1">MNIQKFRIKRKGGRGGFGGGFGGGRGGFGGFGGGGGRGGGFGGGRGASAGRSGSFSGSSNSHGKSGGGGAGMIFFGGSHSTHGTADNNNDKKGLLIIFLFACFIAFMFCLPEKKKKGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z556</accession>
    <name>A0A914Z556_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z556"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5384.t1">
        <property type="protein sequence ID" value="PSU_v2.g5384.t1"/>
        <property type="gene ID" value="PSU_v2.g5384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5384.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9258" checksum="9441EEC77BBFDA47" modified="2023-02-22" version="1">MLLIKPSLEIFAMSPTSPKIPLDPFLNVLPHLKFFQAQYPDINLNPTFFAINNNSLRSMGRLIIGIPTIKRFEVGWFPSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5E2</accession>
    <name>A0A914Z5E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Syntaxin-5 N-terminal Sly1p-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5E2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g79.t1">
        <property type="protein sequence ID" value="PSU_v2.g79.t1"/>
        <property type="gene ID" value="PSU_v2.g79"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Syntaxin-5 N-terminal Sly1p-binding" evidence="2">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g79.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27655" checksum="433D029A5DC69E6F" modified="2023-02-22" version="1">MYDLENHRARRRHQPHIIDQTNSVDINLQNNFEDTKKQQQPTVQRSLGFLPSSDQLAGFSQYIAAPATQFWNSAQSFADQYAFAPREQTPEPTVVAGGNTTTFEEDTFDPFQVIEMPYRDRTAEFKTICKSYEMKILANGRHQNREEKTNLLQSSKEFNARSKRISRYLSITCAKMEKLTELAKKKSLFEDNSIEIERLSKDVQEDVKGLNNQIDELNNIVKQQHSSNQDKILKVFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6G8</accession>
    <name>A0A914Z6G8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g75.t1">
        <property type="protein sequence ID" value="PSU_v2.g75.t1"/>
        <property type="gene ID" value="PSU_v2.g75"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF6">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="269"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="792"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1313"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1450"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="796"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1313"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1457"/>
            <end position="1466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g75.t1"/>
        </source>
    </evidence>
    <sequence length="1496" mass="169040" checksum="6B5227C21450D610" modified="2023-02-22" version="1">MVTPWEVDQNLYCTPPRVFSESVARKPSLGIQEQRRRSIALLRCISDQDSAMSSEMQLTCLPADLRGDRRTIKLIRERKRKLFHSRVYESEVGMKKYYIQTAKKLPAHSCKVFQVKELLHGRTLRKTIRLLCLSSSVICLLDGGSKMVLKRAHASTLQQWRVGGGVSKHQLLLEFRGHKWQLIAPSYNILKSISMTLWEIMQSTASSVIQRSFNCSIDRRLSLGASPAGSSRTASYSSNCSFPGVNGLSEEPITLFRLELERLQYILHFTEEVAFQLSMTEYQLFYGIQPLDFVRYVGCDLANIPIADNPSTVKNLVKRLSEVSSWITHVIISQPTHEERKNCLSSIIRIIDTCWNIGNFNGAIELLMGLRSDKLRPFWLSLKHEERQRYEELIDVLMPTTNSVPSNGYLEAVQRAIRMPQCRLIPFFGTFLRDLYAIVNEMPNIVVIGNENDVEKLKFLNDPNGDDHFSSSIGVAGLLNTDKTNLITVVMENLELFHKHNRALQKQFDKINNPEASTAGEDSEQMEPKPYEPIQPIPNSNHGVTLIPLDSRRFDLDIIQRIQHGTTIIHYDPLSGRSVLCRLMLDSSCSTISWHKIYSGGTKDGKDKENLTGVITSVNMQNLQLPDGSRIAQSPYATLRPMGAAVTGLEEGFLRTSFIKAIESVDPYDVDIEAIYRRHSVEEMSVPVNCWTINFGCMLSDNEMLYFLAPQQVALCWMQGLQAIVRNIQFQQKNADRRVLWLKKLYLQLYSECERGDGYIADYKKIGPKPIDALQSFGGRVERWRGLNLGANPTISTSSKPAESSSSNESGAKSRLKQMTIQITRRVKGASRSASPQPTSPLVRPPSIKSQLSSQSGPPISPGYLLKPRCDTTMSESGDLDSLYTPRSRTPTSSSYGGRSIGGRSVKSWRSRGGETPNSGSISSSGAVSGLNGLSGKEYQEKPLNFPEFVEIFRLFSTRMRKDLKDLFNECIIYSTANVHGKTSREKQSPRLQSRLESITSAATSNDFIPNDVLTRNTALNMFHLNEKQLKIYNALALASIHSTGLMDTSRNSFFLTPTSLKQFICTQQMEQIEESYALKLIQEHEPDPLFRNKQLMSFEGFVRYLNDPSNFAFVPESIEPAEKDLQHPLSYYYICSSHNTYLTGHQLKGESSTEMYRQVLLTGCRCIEIDCWDGDEGLPLIYHGHTFTSKINFRPVVDIIKKSAFLTSDLPIILSIENHCSIYQQAKMAQMFKTAFGEKLVSNFLFDIDFGENPKLPSPWQLRNKILIKNKKLIAEPSAGLQVERTRSDGNLIRRKHSRGSYDSSTIDDVEEDELDDFLDEDEPDTDEDESSSKKDRRESKESENTYVSVERKISKRIHKPVESCASNYTKADDEHEQIWIGGRPRPLGGKLPTGHQIAQELSDLVIYSQAVKFKGFTIQEKAEEVFTDSTFPTPRTRNHTVHLSATTIPPRRQKSSSQISTSDSLKSEDVGSQMLANTRHNPNTHASCYQVSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z779</accession>
    <name>A0A914Z779_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z779"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7750.t1">
        <property type="protein sequence ID" value="PSU_v2.g7750.t1"/>
        <property type="gene ID" value="PSU_v2.g7750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7750.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20740" checksum="5CB85BBAEC6EFFFE" modified="2023-02-22" version="1">MYQQQPQQTQHPVMPPPAHMGYPQPQQYSQQLYSDTSQQQHQQMQQPMNDMSIGSLPANPTYMMQHTPSSSTAASPPCQGPMSAGPFTTQQQQQLSTPALATESQSAPTSPAQNFEPNNRRQQWPPTRHYSASPDTMEIPNIVLTDPDGTFDNCFQGLHLNSDDMRQLMNDQHQLDSACENQLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7U2</accession>
    <name>A0A914Z7U2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7U2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g797.t1">
        <property type="protein sequence ID" value="PSU_v2.g797.t1"/>
        <property type="gene ID" value="PSU_v2.g797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051949">
        <property type="entry name" value="Cation_Transport_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43079:SF1">
        <property type="entry name" value="CADMIUM_ZINC-TRANSPORTING ATPASE HMA1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43079">
        <property type="entry name" value="PROBABLE CADMIUM/ZINC-TRANSPORTING ATPASE HMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="12">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g797.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19424" checksum="2A1E3BDAA50FE7D9" modified="2023-02-22" version="1">MGRARRSIEALMALRPEIALLKLADSSIKEVQAATLRVGDIVIVRPGARIPSDGTIASGSGALDESTITGESMPVRKETGAKVFEATVNLDGVLEIRITKTVEQSTVARMIELVTQAQAAKAPSERFSVWFGQRYTVAVLMVSLIALGIFYWFGHDWEAALYFAATLLVAASPCTGRRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8T6</accession>
    <name>A0A914Z8T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Laminin EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8T6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8746.t1">
        <property type="protein sequence ID" value="PSU_v2.g8746.t1"/>
        <property type="gene ID" value="PSU_v2.g8746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000074">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000242">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000105">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000580">
        <property type="entry name" value="Wing blister, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF435">
        <property type="entry name" value="LAMININ SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="8">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="8">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="8">
        <location>
            <begin position="292"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="8">
        <location>
            <begin position="340"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="620"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8746.t1"/>
        </source>
    </evidence>
    <sequence length="679" mass="75432" checksum="6500A9F005893BE4" modified="2023-02-22" version="1">MLQQLKFVELILVGVNVGFLSEISLSTASSSLYSSIPADWVEQCDCPEGHVGQFCESCAPGYRRAVKIGGPLTKCIKCDCHGHSDSCDAESGACICQHHTSGDSCETCARGYYGNALNGTETDCQKCDCPDGGPCLPLPEGGMACSECPIGHAGIKCEFCASEFYGNPLLGQSCLPCPCNDNIDFNSIGNCDSRSGECRKCIYNTIGFNCEQCKTGFWGNATAELRNECQECNCFSPGTKKGGYKDNNDFDNLRCHSLTGQCECWPHVIGRSCDSCEKGFYNITSGIGCQQCECDPIGSENGFCDSVTGKCKCKPGVTGLKCDQCAREYYGFNFEGCQPCQCNSIGSELRDCDVNSGQCYCRDNVEGRRCDQCSENRFNMRAGCLPCDDCYKLIQTQKNQIVKDMEQIEDGLNYWESHPITINDEKITALIKEERQKVEQFNNKFKGALDSRTIRELKQFKQLIPRASKLLSNLSNHTYFNSIDETADELEIGLKDFQTIRANLTTYLNTEIHRIQKEGNEKLEAAKENVKKYGNFDPNISEMAKDAIKVSRKNTVARDEIKRLSEKIWKNVIQAKQEAEEAIRGENASRKIQDLEKMANQTAALLKKTKAFAAQPVADAEKLFNEVNSLEGQNRQKQNILNKIIQQKNKTESAIKELDAQVSEAKNVLQNIEGMLFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9L2</accession>
    <name>A0A914Z9L2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SPT2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g9361.t1">
        <property type="protein sequence ID" value="PSU_v2.g9361.t1"/>
        <property type="gene ID" value="PSU_v2.g9361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9361.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47200" checksum="440D2F8A273437E8" modified="2023-02-22" version="1">MDGMFDFDILKGARHVYKPPPPPKPQRSMQKPSTPSGPSKHENTQVSTKCINKSMVVKKPQPLSFEEMMKLASKNMTNNEKLDKPSKPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPSKHGNSQVATKSINKSMAVKKPQSVGFGNMMKLASKNLNDKFDKTSKSQPPPPKPQRSSQKPSTSSFPLKRVNTQVLTKSISKSMAVKKPQGFEDMMKLASKNMTNNDKFSKPSKPQPPSSKPLRSVPKSSTSSMPSKHGNSHVATKSINKSMVIKKPQPVGFQHNIPPKHLIKDDRTSRPPKRPRYEYEDDDDSMDDFIVDDEEENVQKELKKVLRNYYRSDESVWQQREKEIDLSKMNARYQDIDAEEKRSYRIARMEDMIEEKRGSKALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA20</accession>
    <name>A0A914ZA20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PARP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZA20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9513.t1">
        <property type="protein sequence ID" value="PSU_v2.g9513.t1"/>
        <property type="gene ID" value="PSU_v2.g9513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9513.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="24156" checksum="243F74DD4A1F8DEA" modified="2023-02-22" version="1">MLNQKSYFFQHSKSNNSICRSCNQLIPQDEIRVYRNDYFEIFPYPRNGWFHLKCFWLLEEVKTNINEKDVMLEIESRERNYENEFWQYQKHKIIKNNTQFSLHDGQNSCFYTSMAFFDSTNSKISLKIDESELLGIRKKIAEIKDLMNNTVPSTPIDDSVEELASNLEKQNNLAKIKDSLNDSISSSSSSGYASAEDFSDSFCSTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBV1</accession>
    <name>A0A914ZBV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9218.t1">
        <property type="protein sequence ID" value="PSU_v2.g9218.t1"/>
        <property type="gene ID" value="PSU_v2.g9218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9218.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12474" checksum="2D40E70D3AAF752B" modified="2023-02-22" version="1">MSSNQETTTYSSESTYTSSNAANTVGDTAEAAKEKASGLLDNLKEGVSNVVDALAGRESSHKHDVQCNKGSCSTYEKETVNYTETSDHERNARLNAYKLKLVSSPKLPMLKLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCJ8</accession>
    <name>A0A914ZCJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9650.t1">
        <property type="protein sequence ID" value="PSU_v2.g9650.t1"/>
        <property type="gene ID" value="PSU_v2.g9650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9650.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="31040" checksum="6C352C97205E0ACD" modified="2023-02-22" version="1">MENLQFKLEKTLKEKLECEKQLQNQHNSLISSYYRLENYLLESNFDEAKKELSQFKQKISNQTTLTNNNNDVILRENDATLFSNGIEETYKILRNVQAEISSLQKDLCDYQQKNSQLRQNISDKENEIKDLKDFEMLQQNTILSLNQTIEKCNHEFGEKESESEDLKRQIDIMLPKYIRNENQTLTKQIESMLIKNSECDKVDNEGDSNAAKLHSLLQDLLVMLKRNKEKCEEKFLDQIDGNILEKGEKHVIEKRDATKMVIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCX9</accession>
    <name>A0A914ZCX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZCX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9804.t1">
        <property type="protein sequence ID" value="PSU_v2.g9804.t1"/>
        <property type="gene ID" value="PSU_v2.g9804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9804.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20416" checksum="E81EDFF1485B5981" modified="2023-02-22" version="1">MAFVVPHSRCLNLTLKQVVACSRQLQLCSSRNAGARNAVQKYGWEYLVRQEKSGRPLSPHLNIYKPQLTWMLSGLHRITGCIMAGTLLVGGIAFAITPVDFTTFIEFVRSLNLPTPVTSIFKFIVAFPIVFHSLNGIRFMGFDLAKGTDIKSVYRSGWLTLGVSALIALAIIIDNARNKKAVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD28</accession>
    <name>A0A914ZD28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZD28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9851.t1">
        <property type="protein sequence ID" value="PSU_v2.g9851.t1"/>
        <property type="gene ID" value="PSU_v2.g9851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9851.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15514" checksum="FD72527AA89DCA74" modified="2023-02-22" version="1">MAGTTLPRRILKETQRLMEDPVPGISAVPDDGNARYFHVVIAGPDGSPFQGGVFKLELFLPEEYPMAPPKDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLATDVAEHWKSNEADAIKTAKEWTRINANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEP3</accession>
    <name>A0A914ZEP3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZEP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8752.t1">
        <property type="protein sequence ID" value="PSU_v2.g8752.t1"/>
        <property type="gene ID" value="PSU_v2.g8752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000877">
        <property type="entry name" value="TAO kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051234">
        <property type="entry name" value="TAO_STE20_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="30"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="803"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8752.t1"/>
        </source>
    </evidence>
    <sequence length="964" mass="111354" checksum="C366FA064D0850D8" modified="2023-02-22" version="1">MPIQPILKPGSLKDPSVASLFSTKDPELRFSDLREIGHGSFGAVYFALDKETNENVAIKKMGFSGKQAAERWSDIIKEVGFLKKIRHGNIVEYKACYLKEQTCWLVMEYCIGSAADIVEVHKGPIFEQEIAAICQQALTGLSFIHEIKRIHRDVKAGNILLTDHGVVKLADLGSVSCSSPAQSFVGTPYWMAPEVILAMDEGHYDQRSDIWSFGITCIELAERKPPFFNMNTMSALYHIAQNEPPKLQIKSSTNEAAPWSEKFISFVDQCLRKDPEQRLSTKACLNHPFITDALPPSIILELIRRTKRVVRELDNFQYRKMRKLMYLDEQQLGMNTVVTMDAISVDSHEGVCEDENASVHSDALHAETCSSISETSGHSSRLSSKRNHRPPLSNVVSKLQDTEESDEIAANEKSRTMDSGVRTVIKVGDTVRLPGSSGEASTAPTISSEQSNSPISTLGISPFHENISKEEAINTLRRNKFSTLRTTKLISREVEAHRTENNIYEQMSGYKRLRQTHHKEVQQLDERIKVESDQLKNKLEKEYDHAVALCDKEIVKLRQSQQAELDKRHRQNEEELKKATKSRKNSNEHELKSFINVQKKEYRHNKDQEKASLKQHNLPRSQYESMLKAAKNEFVIQKTTAEARFREELLARINEELFNLRKNQLILYHDFENKLLHDELNTCARHIETLHSILRRHHSMTRQQEQTHLEEVENLKHRHITIQHESELNNQNDYTRRTLDDLKKTHALQSKQHPRELKAKETQIRKQFRQTCKTQTRQYKAYQSQLMQSVPRDEQKELINKLKAEQTRKIADLAEQYERTIKEMMSEQTVKLETWQEDELKHISDKLSNELNELRAYQAKQREIFKNQCQRDRQSMEDKITHRRSMLEKRMAEELAKFESEREEQLRVMKERHVREMAAFDTSLSPSSTPSSTVTSQYTAFKTNSQFSSNDSPAGSHSSFKSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSH0</accession>
    <name>A0A914XSH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM40 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XSH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10222.t1">
        <property type="protein sequence ID" value="PSU_v2.g10222.t1"/>
        <property type="gene ID" value="PSU_v2.g10222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10222.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="33726" checksum="7F7D882A937DF381" modified="2023-02-22" version="1">MSEPPPSVKPTAEALTPSLQPPVNQNPGAYEELHRKCRDVFPMCFEGAKLMVQKGLSSQFQITHTLSISTANTGYRFGATYIGTQDYPGGETFPVLLADTDGSGNTSATILHQFAEKYRVKLQGQVQQGKLAAAQGTFERRGRLSTYGIMLGNTDLINQSGIVVGHLLRRITERLDLGAELVYQYDKRSGQHSALSYAARYTAPNWTLSSTLGTAGVQVLYHHKQHDGLQFGIEFDANLRQAECVTTFAYQAELPESAVTVRASCDTNWTVGAVFEKRLSPTLPFTLAISGLLNHLKGQGKFGVGLIIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVA0</accession>
    <name>A0A914XVA0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar hook protein FlgE/F/G-like D1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11863.t1">
        <property type="protein sequence ID" value="PSU_v2.g11863.t1"/>
        <property type="gene ID" value="PSU_v2.g11863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053967">
        <property type="entry name" value="LlgE_F_G-like_D1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22692">
        <property type="entry name" value="LlgE_F_G_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="Flagellar hook protein flgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar hook protein FlgE/F/G-like D1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11863.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16168" checksum="41281ED547B354AF" modified="2023-02-22" version="1">MAIDGANGLFRLEQSNGAVLFSRNGQFYPDKAGYLVNAQGHYLTGYGPGGSQLERLQVPSANVPPKATTALDFKPNLPGGAEAIPTTKTQQKVDANGDLVFKPKLDANGNPEMTPKLDGNGDPVLDGSGNPVMEPVMEPDMETVALLRLRFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVV6</accession>
    <name>A0A914XVV6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914XVV6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11365.t1">
        <property type="protein sequence ID" value="PSU_v2.g11365.t1"/>
        <property type="gene ID" value="PSU_v2.g11365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050456">
        <property type="entry name" value="DeoC/FbaB_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47916">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47916:SF4">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11365.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20519" checksum="A66AA56F0EAAD092" modified="2023-02-22" version="1">MTDIAQLLGKDADNLLQHRCMTIPSDQLYLPGHDYVDRVMIDNNRPPAVLRNMQTLYNTGRLAGTGYLSILPVDQGVEHSAGASFAANPLYFDPKNIVELAIEAGCNCVASTYGVLASVSRRYAHRIPFLVKLNHNETLSYPNTYDQTLYASVEQAFNMGAVAVGATIILVRKSQRRQIEEISAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW45</accession>
    <name>A0A914XW45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11187.t1">
        <property type="protein sequence ID" value="PSU_v2.g11187.t1"/>
        <property type="gene ID" value="PSU_v2.g11187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11187.t1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45791" checksum="8392744160AB7BC4" modified="2023-02-22" version="1">MLFLKLFRAVPMTIFIASDMVVQRKYKLERIRLSALNLLQHMTGEMKFSKDLFPTTKDYNLALKVNHDFNQIIDAMLRQAMRMVGFELNQSITNLSIAGFTEPESREKWLHRIELLKDLADDLIDVPSAASIDKLRDIDWIYLLPFEQQEYVVQKLSEFIETGNLEIVSNHACIYTHGTHLFFIRKGICKVTEIQNVKQHRICHDYYIYDGSFIGIKNIFKMGKNGNKFQPLKNLETSFRACTDVELVKIEATKWQKLFQDVVECWGTISMVEQKRRLRADLKRVSSEYGLMTDAEIAHETLTFYEVRGKKTLSLGVGKVFIPGIALHVVAHPEGRIDEFRNILGPANVTIQPITPEIVGLYLELIRPDMSERAMKSSMIAANIPMSPDTTERRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWM9</accession>
    <name>A0A914XWM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11372.t1">
        <property type="protein sequence ID" value="PSU_v2.g11372.t1"/>
        <property type="gene ID" value="PSU_v2.g11372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062:SF1">
        <property type="entry name" value="LP12374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="329"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11372.t1"/>
        </source>
    </evidence>
    <sequence length="1072" mass="121779" checksum="415FF391D05B5455" modified="2023-02-22" version="1">MNNNCMDPFRALENDLDDAREVIQSLAQQGNYMDTSRTPSPPYGDQYYTYPNQNPFQSRQYEHNIVPYSSQPQMNGYRQYPPPPSSNDLLESGQYQTIPESTVMPRHGQQISNDQFWMEHDSYNSQQPIYMETNGVQIEQQQPQGLPPAQIFTTSPTLPPTEYLNNEYADQFVTNVAYYSPPLPQQQPPQTQPQIVYQQTSPETNVSNASPPMYPNVPESSRSKEQKVIELLLEMSPREWQNLRTKNQIISRGTSLDIKQEPKDKPSGVATKLTKQVTSMPDIASVASISPPAVVSPTALSSNSGEWRDDSDNDEFEPLPVTRKGPKTERRTAHNLIEKKYRCSINDRINQLKDMLAPEEGKLSKSATLRRAVEEVSSLRAQNAALVVENEKLQAAVRALASNSSESAESIIAQINNSANKVKKGMLDKSRVSLCIFLCVFLAFNPFSLFLSTSDGVAGEAHHQPPLNPDDPIIYKVHHRTLKSIGDEPPFELDTSSWIQESFVRNSFIWAINVFIVVFVLNRLLVYGEPVADGQASSWRQFLSVKQLANRYINDGNYKEGQRQLLDSLQYLNRPHPTSSSEFTSVVWQIFRHILNSLWIGRWFSRRRRSAAQPVPFVRKSHAASALVYHQLHQLHLIGVDGIESDSLGGLNLALSAVNLAESAGISRDGTGITYKIRADIYINAAIRVRLALPRFLGTVLFHYFMGRARRHVRKARNVEGEDVSALDWMVSNTPLMRRFLAKSDNLEKVLKCSKNFTYYPFSDGVPTAKPIDRLTFAFKMHLLSTLSEKLLKSNDSERPEDFIEISHILLQLSTNDPKQKSGEEEWDSDCSTRGDELCTWWTHLITCGLYWRYGDSTRSQKHYALIRKCPSILLKNDLALSMGFAFCARKLCIDNKDNDGCAEMVWAHVRASFGHIKKETRISPRKAAPTVAHLHKTIESITCQWLLTSTIDVWHFQLKDSLPYWEQRTSTSLRRLFHDILGRMKTLKLESDKSKIATFKFLGHAISGANPLEIVELFRKIEGQTSGNKLTKQQINDKKRPSLSLADIQNHYDVFKRLQKDVSTIISPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWR1</accession>
    <name>A0A914XWR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12383.t1">
        <property type="protein sequence ID" value="PSU_v2.g12383.t1"/>
        <property type="gene ID" value="PSU_v2.g12383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12383.t1"/>
        </source>
    </evidence>
    <sequence length="428" mass="46427" checksum="04B6E3DE79194AB2" modified="2023-02-22" version="1">MESTFTDDIKLIYNALNPETTQVTAFSATYPNDFDKYLSGFMKSPISYRIDSQDVQLLGIYQYAVVGLALRPVDIIKKLLEEISYAQSVIFTNQSEKCVQVSNFLSDSRFKVAAISGNFTQEERKKVINDLKNFALRIMVSTDLTARGIDAPNVNLVINVGVPASLETYLHRIGRAGRYGGNGASITILTTQQEVANFVRMTSAGGLNVKYLDILKDIPYDLTYNANFNLESLGFIDSCNKVVADVKADVARSEEVKPTKTIVNNCENNDVIASPSPVEVVSQTNSLSVAPQDVIGSTPVSQTPSVSAPLPSTSDVQQSVPETNVVEAESSNSEVFVAESPKKSASSSSFIIPARPDPWSGEPPQPRLSTDTTTPLPIVNADAVRQFIPSFEQDIEADIAKAKAAAEEAPPVPDVCCFYFTAEHESVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXI6</accession>
    <name>A0A914XXI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1046.t1">
        <property type="protein sequence ID" value="PSU_v2.g1046.t1"/>
        <property type="gene ID" value="PSU_v2.g1046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050976">
        <property type="entry name" value="Snaclec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991">
        <property type="entry name" value="PROTEIN CBG13490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22991:SF40">
        <property type="entry name" value="PROTEIN CBG13490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="120"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1046.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27638" checksum="0770C9D2967FEB4D" modified="2023-02-22" version="1">MIPASEYQQAVNSIEDVVSLPTVATIGIGATTGPTSYPWYTSTTYWGWGSTTSNPWYWTTTTNWYNNPTTEYPWWWSTTTTNWNNPTNYPWYTTTTPDYWGTTTRNPNNMCPYGAISSMSKQQCFQLFFKSLTFIEAEMDCQSRNGHLASIHNAFDNMLLNDYARNMIGPNTQYYIGANDLTNKQWAWTDGTEFDFVDWYTYQSGNDYADCAVVDTSHGAWIKSDCYSGAFYACTVPTYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXR9</accession>
    <name>A0A914XXR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXR9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11752.t1">
        <property type="protein sequence ID" value="PSU_v2.g11752.t1"/>
        <property type="gene ID" value="PSU_v2.g11752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11752.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31739" checksum="7E04E2F5D9CB3BC1" modified="2023-02-22" version="1">MLVSIKTFTGKTITLEVEGSDTIENVKAKIQDKQGIPPDEQILILDGKQLENSRYLSDYSIRTESFLYLARRILGGGLALNGEELIGVKVNEDGVGLSLTEDFQENASVSYTPKECLKQAKLYFNESPKSLIQSAEMFWLACQRTVKTAFLKEHVHIISHNSVNLLVKSSLDTIENENVREVMIAYWSYAQDYYKHFNDIEIELDDFERRIKSMDFFVENFERLVGGNLKGVSDDLYARIQRGEEVKHGGRKIIAKKILPSKTTSLANTTYHYDCWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYL8</accession>
    <name>A0A914XYL8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XYL8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12049.t1">
        <property type="protein sequence ID" value="PSU_v2.g12049.t1"/>
        <property type="gene ID" value="PSU_v2.g12049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12049.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15696" checksum="69DA81C2A3E4F777" modified="2023-02-22" version="1">MPPRMTAKNLSDISMLCPDLTPDLLSMVDQPLRIQKDKQNGREYILCDYNRDGDSYRSPWSNSYDPQLEDGVLPTDKIRKLEIEANAAFEAYRDMYYEGGISSVYLWDLDNSGFAGVVCIKKDADTLSDVKGSWEAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYN7</accession>
    <name>A0A914XYN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12324.t1">
        <property type="protein sequence ID" value="PSU_v2.g12324.t1"/>
        <property type="gene ID" value="PSU_v2.g12324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12324.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9618" checksum="1ABE2671F061A30A" modified="2023-02-22" version="1">MRKKCRLIFCEILKMKFYVFALLFFFAAIFAVNGVNIEETEAGKHGEKHEYFMGKQCWSTADCPRNQICLFPIPHHGEPGECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYT0</accession>
    <name>A0A914XYT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYT0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12108.t1">
        <property type="protein sequence ID" value="PSU_v2.g12108.t1"/>
        <property type="gene ID" value="PSU_v2.g12108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036966021" evidence="2">
        <location>
            <begin position="23"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="3">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12108.t1"/>
        </source>
    </evidence>
    <sequence length="446" mass="52150" checksum="F471DB6AB2FC6A6F" modified="2023-02-22" version="1">MTKIFSQFIFGIFLLCIVSINGQYSVNDLSDDNPEEIINKTYAEEQTDLQNHIFKNYNRRARPLQNQTLPITVEAYIYLMHFSVDESQQTLTLNGHIYLSWMDEVAVWDPSKFNNIRNTLAKQWELWQPDLKVANSVSGVNQFFEISRRSHATLESISPTSTKVQTYPTFLMKIGCHFDYSKYPYDIQKCALRLYPAARMNEVVLKVYYELSPSVLLGWGEEAENKHIGEWNLLSVDNNITYFRKRKFSNDRPPNAFEASRTWSIFMVYVTLERHVALYWITMGLPAIISSIFNVFSFLFEKPEHAIMVTIGNLFFQIVFLQDFIRELPPAVGQAPPIVRFANALLIMTIIAMLAHLFIKRLKTHQSKLPPKYSRYIYNLLEAIKKRGKTLHTNEEEGHEEIEVSSEFTSFGIQNDKPLMMHYLLRGILFSFYTLSTFFLCLFYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ33</accession>
    <name>A0A914XZ33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZ33"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10937.t1">
        <property type="protein sequence ID" value="PSU_v2.g10937.t1"/>
        <property type="gene ID" value="PSU_v2.g10937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10937.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26335" checksum="3314E9D30F821C9E" modified="2023-02-22" version="1">MVCVDSLTIATESSTVASARIFYWGFNVFAYLLPLSLCIIFYLLLVKKIWKQKIVTSKTSQKMKRHATRMVFAVILTFGICWFPQNLRFFLRGYNYPGMSFWEHNTEILVLMQSMAQILAYSNSCINPILYGILSERFRTGLAIAVDKVLCLNEKDGGRHKRHAFTQSAFSRSVVPPHSSPSITKLCTPVEDLLPKHSSSKSNLIIPSVPEKATTVYMDFKTSDSEETQVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZM6</accession>
    <name>A0A914XZM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GIY-YIG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g111.t1">
        <property type="protein sequence ID" value="PSU_v2.g111.t1"/>
        <property type="gene ID" value="PSU_v2.g111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g111.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29911" checksum="E8ED1E0A61CDB1AC" modified="2023-02-22" version="1">MITQHRNKIEYIFGATTFHSSFSDPNRRIRQHNSGQQAGGAKKTDNRGPWDMVCIVHGFPNSVSALRFEWAWQNPDKSRRLKEIVLKKSAKESQFAFRLRIVCHMLNADPWKRLAWLIPLEEIPFPADIPPPKHMVKKYGLVEKSNETVSKDPEAYQKVEDCLICSQPIEALSQFVRCQQMKLCVTHYHTRCLAEKVLKQSKEFEVAIVPIEGRCLRCHSSWRWGDLIRDQQKLLQISTVAQEQHRISNAALLIPRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1A1</accession>
    <name>A0A914Y1A1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y1A1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13983.t1">
        <property type="protein sequence ID" value="PSU_v2.g13983.t1"/>
        <property type="gene ID" value="PSU_v2.g13983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF29">
        <property type="entry name" value="ELONGATION OF LONG CHAIN FATTY ACIDS PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13983.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="32057" checksum="A7C7400487E5AE43" modified="2023-02-22" version="1">MDIFLKEYDYSASKQWCIDHEGFLLKAVGFYLVSIFGIKYFMKDRKPFGLEQPLIIWNVILSTFSLLGFLFITPTLFNVIRKNDLHVYTYTHITELQTGKVAGYWTFLWVVSKIPEFVDTFFIVLRKKPLMFMHWYHHALTGYYAFVNFSEDNAHMIWIVWANYLIHFCMYGYYMLRALHFRIPPQVAQTITLAQMVQFLISLASMAHLTVLHYTTTQHLAFTFRGIAIASFMLSTYFVLWLRFYNISYLQAGGKKYVQHQEKVNEIKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2P7</accession>
    <name>A0A914Y2P7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2P7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13512.t1">
        <property type="protein sequence ID" value="PSU_v2.g13512.t1"/>
        <property type="gene ID" value="PSU_v2.g13512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13512.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8215" checksum="658C8C5863DDB70C" modified="2023-02-22" version="1">MLDAAKEFDRRFGGRTTAQKFMVVFTDAYSQDDPVDASAKLYQERVKVLAVAVDDARQPPDHEQLKAIATDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2S6</accession>
    <name>A0A914Y2S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2S6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13544.t1">
        <property type="protein sequence ID" value="PSU_v2.g13544.t1"/>
        <property type="gene ID" value="PSU_v2.g13544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13544.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="19256" checksum="B4939172786C804D" modified="2023-02-22" version="1">MKNKGNGNGNGNKGKGKGNGGGNGSEEGDSDNNGNGKKPNANGNGNGNGADSSESGASGAPNGNNHGKGKGDGSSESGGASPDGDNGNGKNKGGKGGNGGKDDKATMIMEPDGGVEAINKGDEEDRTSKGSESGSGNGEGDGKGNGSGEGSNNNGDGSSPNGSGNNGLGDGDGNDPNKVKVISGPSHLSSEKPDGDGSNGPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2W2</accession>
    <name>A0A914Y2W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2W2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13577.t1">
        <property type="protein sequence ID" value="PSU_v2.g13577.t1"/>
        <property type="gene ID" value="PSU_v2.g13577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13577.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22097" checksum="904FAF377C9A2A3B" modified="2023-02-22" version="1">MEKKKSGILESFQFLWIHQKYIRYLIATIFLWITDMLLYNAMSLISTSLAGDAYLNYLFSGIIEIPAYTFIPLLINRIGCKKFVIIVHIFTAAALFPILFIQPDFQIIYITFWLLGKLGAAVGIVSLFVYGAEIFPTNIRSTCLGTAAFFGNIGGMISVQTQYLKQINPIFPAAFYSFMSFTAGIITLFLPETVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y349</accession>
    <name>A0A914Y349_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloendopeptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y349"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12199.t1">
        <property type="protein sequence ID" value="PSU_v2.g12199.t1"/>
        <property type="gene ID" value="PSU_v2.g12199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1940:FF:000002">
        <property type="entry name" value="PHAryngeal gland Toxin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF829">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="16">
        <location>
            <begin position="3"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12199.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33139" checksum="535B99AF4958BC5B" modified="2023-02-22" version="1">MLNALKNKQLTWTDGNVPYEMDDAFTQGEVRLIERAFNSYKKRTCIRFKKRIDETDYLYITKGFGCYSQVGRTGGKQELSLGRGCLFHEIIVHELMHSLGFWHEHSRIDRDDHIRIKWENILPGMKSQFDIISGALQDTLGENYDYRSIMHYDSTAFSRNGQNTIETVVDGFTGIIGSATDLSDLDVVKIGKLYKCSKKEEEIKTTLPKKKTTKSISTEMVTKARTTTLPPSDIPFSSSPSPSKKKGDSNKCSDQFLDCPNFKDYCKKVSFFFVMKAYCPFTCNHCRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y356</accession>
    <name>A0A914Y356_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y356"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14616.t1">
        <property type="protein sequence ID" value="PSU_v2.g14616.t1"/>
        <property type="gene ID" value="PSU_v2.g14616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036882778" evidence="1">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14616.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12734" checksum="942091E114B1514E" modified="2023-02-22" version="1">MQQNMFSMAQISFVCILVLGSFSATILAKPNNRLYYLFNDDNSAFRLSPYYRAYDSSIIVPASDSAASQPVDTDKRAPMKKNYDRNCFFSPVQCMLSYNTKTHHDAYYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y456</accession>
    <name>A0A914Y456_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y456"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14012.t1">
        <property type="protein sequence ID" value="PSU_v2.g14012.t1"/>
        <property type="gene ID" value="PSU_v2.g14012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF133">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14012.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14189" checksum="137F855E242E80E4" modified="2023-02-22" version="1">MREHNRIARQLESINAFWSDEKVYLETRRILGAVFQHIKYDLIPKKAGYFHGYDSTCDASISHPFATAAFRFGHALIRRMFCRLNSFYRNHSEPVDLVQNFNNVESVYDKENGGIDSLLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4E5</accession>
    <name>A0A914Y4E5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4E5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14311.t1">
        <property type="protein sequence ID" value="PSU_v2.g14311.t1"/>
        <property type="gene ID" value="PSU_v2.g14311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="4">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14311.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30030" checksum="5B153C4DF0D54104" modified="2023-02-22" version="1">MKGLSNSSATDDVNNNNNNAVTNTPILVTLDQKFICFDVEQVLDAKQKLQIGRLEGNKRVAWRIRTNAPTRYIVNPNGGVLDDTCSSQSLTVELVGNRYNPHHKLVVQAIQILDSESPKSIWKSQRAKDHEFVQTINLELSTTLMNLEFTQQMSNDRAAQSSASLASLLDQSSTAGPDRINELESLYSMLKSDTEKIQSNVDKTVKLKEVLDSHLETRKQTIKNLTGKIEENENRINQLNSKIKGQEAALSEVQARNKMNENKDCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4L9</accession>
    <name>A0A914Y4L9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4L9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12668.t1">
        <property type="protein sequence ID" value="PSU_v2.g12668.t1"/>
        <property type="gene ID" value="PSU_v2.g12668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="182"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12668.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43061" checksum="061B846C053F088A" modified="2023-02-22" version="1">MPARPFEMIDNDFTFMEEANNETLGIPIFKLIQSGPLKFLTTAVTEYLVFETTIVAKENLHGIYSFKKTQLATKNFLIQPIFENINNVISDLPILIKHSEADFQNATSIKVAVLDLNKNSDFESPLTPFCEQFKTTLKLHHLDTPGVTSVKVQIIDGKGIWSTAQIGPFAYPEIYYLRPNSAPQTWLIVKSGDVKRLLKLLPKTSPFDCSNVFCHSNVSITKEWLESVGIKYVVIKHRPGEYVVVKAGTLYQIASCGIAIMDKCSVYLNRCILESRLSYLCCCVDMHAHFDAGTWCSLKTLRDKEEVELVKAFQGSFRKRLPNKSILRPLNDDVQPKHSNQMTPDVARQYVQMVSSNISSAQLDIIPAVETPESQKVCNNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4U9</accession>
    <name>A0A914Y4U9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CRIB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4U9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15225.t1">
        <property type="protein sequence ID" value="PSU_v2.g15225.t1"/>
        <property type="gene ID" value="PSU_v2.g15225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="4">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15225.t1"/>
        </source>
    </evidence>
    <sequence length="620" mass="67960" checksum="045BC8D1230C7832" modified="2023-02-22" version="1">MFSYGMNPWSGYTGAQILSAIDLEGQRLDCPEACPIEFYNIMQKCWAHNPEDRPNFDQLVSCLPDLMPQLLITVSEHHSQDKTLLNFNRNEVIILLNRCPSGVTNSEYWLGAMRNGTIGLFKPAETVAYLGAESPAPATVNFRAPIIKKKDATKVSKVPAEKKKLMISEPQGDVRHTCHVGIDGTSFGILEGDKNLLSKALPPPFPTSPTAAAATSISGNGDAKVPPRPAPRRIPTLSNASPVSPGTPVRHISSEKNINAFPTSEIGAEKSPPILFPRNRAMSPVPAPALPPKPSAGATTAIRSSALVIENRMISPASTLNRRTVAGDIAAEFRDRKEQLLNFPNSSEYSFPSGNTTTTSSSTISSHPESVLDQVLSDLQADITNFSMISSKTSDSMDFSDTRPLLNGSRGYNSTTKILDNSDGILADMNDKDFEAFKKRANHDLAKAAKELEKQRSLDRKASKASLLKKELSEEKQFQLQQQKPLMGQFSSKIEPSKFQHKDDSWSPEAQEAYKLLVQCGNRLKSTSPNPEKRSSSSSRSSTSTELTIISGTQYTRASAPPLEEEPTTLERNNYENRTSSTIAPTKAPPPSVLPKPKMRYPIEARRIGDYENQSEILKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5L4</accession>
    <name>A0A914Y5L4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5L4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14728.t1">
        <property type="protein sequence ID" value="PSU_v2.g14728.t1"/>
        <property type="gene ID" value="PSU_v2.g14728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF4">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036998748" evidence="3">
        <location>
            <begin position="18"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="130"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14728.t1"/>
        </source>
    </evidence>
    <sequence length="472" mass="53089" checksum="4AE8DDD9B91FAFEC" modified="2023-02-22" version="1">MWLKLIFASFFIISVTSKAIRDLDFDFDSALCENRLSAFLVTDNADVVSASAARQISNVTEEECMEICSSNRDSDGRLVICASFTYDHVNFKCSIYKRKSGPDGDLEKVTTAGKRFFEKFCLDEDSPKQCASAQFVRIDDSILSGYAKNTSIHSTMAGCINQCLKEEFMCKSAMYFYEEGECITNVESGQTVPEDFGSPDDGDKVVYFNNGCIQPDSIKNDKLSVVDNEKDIKTEKTTDDEEKLVEEEKQATEFETTTVEQSTEETTTSEATTVSEKTDIDTEKENEITNEEKEKAVKDFDNRLYGAKQLSRSENGTISIDEEALEKALEAAEKQYSKEDKTEVSDSKEATDFKEVDVKEKETLKSLEKSLEKSIEKAEAIEKEIVSEKKEKKIKSPVFQIDDSTESAEETTTAAVEIEAEKKEIELPPVNLLKTNPLKAASTKHLQIQKLVNASPEQEEELPRVIVEIKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5M2</accession>
    <name>A0A914Y5M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Surfeit locus protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5M2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14737.t1">
        <property type="protein sequence ID" value="PSU_v2.g14737.t1"/>
        <property type="gene ID" value="PSU_v2.g14737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14737.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="33075" checksum="17570386E2746927" modified="2023-02-22" version="1">MNSEIFQHFMMSMGHNSKQFLGSLEDYADDFLRRTKHYLPHVARFCLVSTFIEDGFRMWSQWDDQRQFMQESWNCGWFFATLFVLFNFFGQFIPVIMVMLRKYVGIACALLAGVVVLQTVAYHILWDLKFLARNVAVGGSLLLLLAETQEEQRSNFAGVPQMNNDNKPKSWMLLAGRVCLVFMFLSLIHFEASFIRMIELLVGVVLMTLITIGYKTKLSAMVLVIWLFGLNLWLNSWWTVPTDRFYRDFMKYDFFQTMSVIGGLLLVIAYGPGGVSVDDYKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6T8</accession>
    <name>A0A914Y6T8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-Fucosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 11 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y6T8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15925.t1">
        <property type="protein sequence ID" value="PSU_v2.g15925.t1"/>
        <property type="gene ID" value="PSU_v2.g15925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11301">
        <property type="entry name" value="Fut1_Fut2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15925.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="42530" checksum="F910DF07F52AE86C" modified="2023-02-22" version="1">MLPKKEKKDQILLQKSKFFLEEVNELKFSDSPWPIPPTKIYASIDELDKNEKYIMSNFSYSPGLGNLMFQYASLRSFAEDHNANLILPSNTLLRRAFGNFDNKVIFLRPQAIDQYLIKNQKLAKVYNECCKFYSNISLFFEKQSIEILNGYFQSFKYFNDKKEFILKQFKFLPLINDRAHKGLEDAKFKLWDEELNRDPEEQGNDVVVKLPDMFDSEYYFVGIHVRHGLDITMHSRNIRHGHTFASIDFYQNAINYFIKEYHWRKLIFVVAGDDLKWAKKVFSQFFKEKFLYVESGQREIDLATLRLCNATILSTGTFSWWNAYLTNGPTVYYSGWPRLGSELDKLVTKSDYFLPSWISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6T9</accession>
    <name>A0A914Y6T9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6T9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13354.t1">
        <property type="protein sequence ID" value="PSU_v2.g13354.t1"/>
        <property type="gene ID" value="PSU_v2.g13354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000157">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="98"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="195"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13354.t1"/>
        </source>
    </evidence>
    <sequence length="643" mass="71566" checksum="D4300B9576B5A0A6" modified="2023-02-22" version="1">MAPEIVKRTPQGYNECVDWWSLGVIAFELVTGCSPFTVDGDQNTTHDIAQRILKKRVPFPKNMDSQAKSLISGLLEKDASIRLGAKGVNEIKMHPFFQGINWELVEQRKMPPAIKVVQNNKMDLNNFAPEFTSQIPLFSPVSSPPDYKGIFRGYSFVSPSVIFSNNNSVGQDSLADSVKLLSKNSSFFSKYELDISESGYLGRGSFSMCRKCRRLSDNKIFAVKIISQKCSHHALREIRILDHLGYHENIVKVEEALSDPLHYYIVLELLEGGELLQRLRKLEKFTESEAARIMYQLVSAVTHMHSKGVVHRDLKPENILFESEDATAKLKLVDFGFARLLPNSVEQLSTPCYTLQYAAPEVIEIEDELPQYNQSCDLWSLGVVLFTMLSGNVPFHAKTATDTATDIIARIRMAEFSFKDSVWDSVSDLAKDLITGLLTVDANKRLTLQQLSAHKWLRAAFDSSQAHELQTPTILPSSADDIFNDTFNAFLTANRDGFQLMDVDTAPLLVKRRGLKRRSETDKHATTGSGINSAGTGSGNRKVSAAYDSTKLAPVMEGPEGDSRPGSSMSGNGNGGINGRPTTLNIEKMDDQPNSIFFAYRDNNLPPYLKYSRDVEPIDDISKHRNNSQGSDASTSSQVSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7X3</accession>
    <name>A0A914Y7X3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y7X3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15554.t1">
        <property type="protein sequence ID" value="PSU_v2.g15554.t1"/>
        <property type="gene ID" value="PSU_v2.g15554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="73"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15554.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37619" checksum="A0AA918243CB5EF4" modified="2023-02-22" version="1">MHDRVYIPELLRSPILAQLHVGHNGMCRTKALARRHCYWPGINADIEKMIAGCYECIQASTAPIKATLSSWSVSTAPGQRIHLDFAGPMHGYMVLIAVDSCSKWIDALPMKHATAHETTKFLLRYIADNGTPHLVVSDNGSQFTSAEFQSFCKANGIKHMTSPVYFPQSNGQAEKMVNVYKRFIKKKALQNPDCFDIDIATSQFLLSYRTTPNTATPGHCTPAKAHLNRELRTILDQIRPEIAAQFNENTKQNDAFDRHHGAKARCFSVKDTVFYRLKKNSSWKAATVIARVGSRLYCLMDAETKKEIRVHANQMKHRIAATPTNNTLRFLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y873</accession>
    <name>A0A914Y873_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA helicase HrpA C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y873"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15648.t1">
        <property type="protein sequence ID" value="PSU_v2.g15648.t1"/>
        <property type="gene ID" value="PSU_v2.g15648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase HrpA C-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15648.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13159" checksum="28C4C1798FB017C1" modified="2023-02-22" version="1">MGGLVYRGFVTGNGFKRLGDTLRYLQAIEKRLEKLAVDPHRDRAQMLKVENVQQAWQQWINKLPPARREDEDVKEIRWMIEELRVSYFAQQLGTPYPISDKRILQAMEQISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8N5</accession>
    <name>A0A914Y8N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8N5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13944.t1">
        <property type="protein sequence ID" value="PSU_v2.g13944.t1"/>
        <property type="gene ID" value="PSU_v2.g13944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037195499" evidence="2">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13944.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="20637" checksum="02ACDACF203466CD" modified="2023-02-22" version="1">MKIIFLIIGILTIGECEIFRYRRSSILEAACKRKPFLGFCKDGSGGRSKGPINPSRPTPSRPQLSRPQPSRPQPSRPKPFPFGTERFGGRLGGGDFDRSDRTQGGNSNRRKISGTNRPSSVSESLGLGGGGSGGGGGGVGIGSGVGVGVPGVGPIGVNSGLGIGAPGIGGGGGGGGLGLGNGGLFGISSGFGIGIPGVGPIGVSSGLGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y956</accession>
    <name>A0A914Y956_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y956"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16725.t1">
        <property type="protein sequence ID" value="PSU_v2.g16725.t1"/>
        <property type="gene ID" value="PSU_v2.g16725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="3">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16725.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17156" checksum="0D2CC0C32DB931ED" modified="2023-02-22" version="1">MADRNLTTKIIELKYGMKNLTLQVIVLELGPIRRTVNTNEVRTCVVGDYTGIINFSIWNEYCHLVKTMDIIRIRGGIVNAHKRSLNLSIIKSGDIMKIGEFCFGVNESVNLSQEGYIPQDVWEKIQQEEEGRRQTISNGTNGRNNPTITNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9E4</accession>
    <name>A0A914Y9E4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9E4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1606.t1">
        <property type="protein sequence ID" value="PSU_v2.g1606.t1"/>
        <property type="gene ID" value="PSU_v2.g1606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1606.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30059" checksum="BBD83EF6CD676B04" modified="2023-02-22" version="1">MKLNIAYPNTGCQKTLEVDDEKILRTFYEKRMAQEVEADALGDDWKGYILRITGGNDKQGFPMKQGVLTNGRVRLLLSKGHSCYRPRKAGERKRKSVRGCIVDANLSALSLIVVKKGEQEIEGLTDSQVPRRLGPKRATRIRRLFNLSKTDDVRDYVIRRTYPEHEKDGKKIKQRVVTPKIQRLVTPQRLQRKRRRISDKNQRRVKRREEAATYQKLLTQYQKEQKDAKVARRHSSTSVSEKKNSVSEKKAPVSKSASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9S3</accession>
    <name>A0A914Y9S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9S3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16186.t1">
        <property type="protein sequence ID" value="PSU_v2.g16186.t1"/>
        <property type="gene ID" value="PSU_v2.g16186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038045766" evidence="5">
        <location>
            <begin position="24"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="7">
        <location>
            <begin position="190"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16186.t1"/>
        </source>
    </evidence>
    <sequence length="589" mass="67485" checksum="3EEFDDAE63CE8118" modified="2023-02-22" version="1">MRTVNIITLGSVMFLLFIDGFYSQPVAPDSQRSASDSQPIAPIIAPPATKTTRGGSLLTHDGYEYRIDRISTVNENVIHWRCVQATCTGRVHQNTVTGTITVRSEHKHGRSETAIEVRARKEMEKDLAKIPLPPQDLPPKTIYSMATQGLTGEALHAYHGADASRHTIHRMRYIPGTELVDKKGLIILLSDGTFYITPENFMQTYILSAIVDGSALPCIYVLMSNKDAVTYERMFRIIDQHVHASPQRLMTDFEEAAIIASNNVWPHIRTSLCIFHLGQSVQKRVKDAHLSNFYHSKNGERFRIDIRRTTALSALPEFLVERGFDVLLKYAHNSAKPIIRNFGKTYIRTATGTQPRFRIASWNMHDAIKHNLMRSNNAVESNNRVMNNHFRARRPKLSKLIIMFKYEQKLWDQRYDLWRQGTTLNLLIGSTCKKFEQWIDWTVDNEEEEIIPQDNGGDNIDVIMQHEESVVDDDGDGDDDDFEPDRLNEVHEMDYEEDDDAGVDPSQSHLKGNVVGPSQKKKKKSSHHHHHHKSSRRYDDSHEPSYRRHQSPRHHDGGNGHVYNELLGSSQPYVKDRQSSDRPRNSRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAA8</accession>
    <name>A0A914YAA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAA8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16216.t1">
        <property type="protein sequence ID" value="PSU_v2.g16216.t1"/>
        <property type="gene ID" value="PSU_v2.g16216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218422" evidence="6">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16216.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="35244" checksum="A40D5EC3D2AB74C1" modified="2023-02-22" version="1">MTKLIFLIFFIIQKCFSIEIYNETIEQKLDHFNDNDERVFQQDYFYTLDPNSNIVFLYLSGEKVLNKSDGILSGQIPTSIPSSYFNLIHRFYGDTLPLMPASEYIKYLNVSQSLADIKNFIEKMNEEFNLQNSNWIIAGSFYSGTLAALARHQYPLLIKGAVTVSAPLKASLYIDFMDTVIEKMKEIDENKTVQIQNAIETYYNFTTTFEGQYYLSNLLEDDYFIRNDTECYPAFYDPTKFFVAAVESGKIVEFFEKWNDESFETFIELILTIGERDDKANGKIIYRVYQEKVYPFFWLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB04</accession>
    <name>A0A914YB04_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="8">6.3.4.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>7-carboxy-7-carbaguanine + NH4(+) + 2 ATP = 7-cyano-7-carbaguanine + 2 AMP + 2 diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914YB04"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17390.t1">
        <property type="protein sequence ID" value="PSU_v2.g17390.t1"/>
        <property type="gene ID" value="PSU_v2.g17390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="7-CYANO-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914:SF1">
        <property type="entry name" value="7-CYANO-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17390.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15267" checksum="76B62CC16A4AECBE" modified="2023-02-22" version="1">MKKAVVLLSGGMDSAAVIAMAQEQGFAVHALSVRYGQRHTSELDAAARVAKAQGVVAHKTVDVDLRSIGGSALTDDIDVPEAGGAGIPVTYVPARNTIMLSLALGWAEVLGANDIFCGVNAVDYSGYPDCRPDHPDASMKLRTASGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC40</accession>
    <name>A0A914YC40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YC40"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16325.t1">
        <property type="protein sequence ID" value="PSU_v2.g16325.t1"/>
        <property type="gene ID" value="PSU_v2.g16325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="107"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16325.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41462" checksum="5FC99D7E460390A0" modified="2023-02-22" version="1">MATDNRLDIIELLFPQYDLTEVAANYAGYSTEELIDWILQNAKKIPVKKQQLKRSQSLRTIKSEAAKTIYSEMVENSLNKSFISRFISRIFRWVYSIFRRFEEKSNSELTCGTCFDGLERENAISCNGASMEIHFFCHKCIREQAKAVTEFAPMADGGCGFKCMEYNCENIILLSEIKQFIPRTIRKRIDDRILEETLGNCGIKFERCQACNFAVEMNVSTKVNKVFNCLKCHKNWCRICENEWDDDHFGITCREYLKNKGENAKKRILEKKMNEAVVRKCEKCNFQFVKAQGCNKVVCRCGVAYCYICRIKDINYDHFCKCVGNIGACVCGKCRLHMEANEIHEKEIKQVTANFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCA7</accession>
    <name>A0A914YCA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCA7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15108.t1">
        <property type="protein sequence ID" value="PSU_v2.g15108.t1"/>
        <property type="gene ID" value="PSU_v2.g15108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15108.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13219" checksum="42DD80B9E4B96948" modified="2023-02-22" version="1">MGIKDSETNEEETAILEKFKQNVKFKDNRYYVSWPEKEVHDKLPTNAALALGRLNSNFKRLSNDPKLLNDCGKIVEDQVKRGTVEVAPDIPEGDIVHYLSSHAVVTPQKTTTKGEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCC9</accession>
    <name>A0A914YCC9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine racemase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
            <ecNumber evidence="12">5.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">D-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">D-serine dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">L-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">L-serine dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-serine = D-serine</text>
            <dbReference type="Rhea" id="RHEA:10980"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="5.1.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EC" id="5.1.1.18" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914YCC9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16412.t1">
        <property type="protein sequence ID" value="PSU_v2.g16412.t1"/>
        <property type="gene ID" value="PSU_v2.g16412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006563">
        <property type="term" value="P:L-serine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000041">
        <property type="entry name" value="Threonine ammonia-lyase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="17">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16412.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36149" checksum="2BE12116B7E6B13B" modified="2023-02-22" version="1">MEYILSATGIELAASRIATAIHKTPIFTSDTLNDYVASLTNTGKGPKLYFKCENLQKTGSFKCRGASNAVAKLLSGPEKDQIKGFVTHSSGNHGQALAFAAKKFQTQCIVVVPSNAPKAKVKAIEGYEAKIVIVEPTMEARKGKCNELAEKEGLQIVDPHDDWNVMEGQGTLSLEIIEQVPDVEAVLVSVGGGGLIGGICQWFHERKPKVQIIGVEPEGKNILESITAGKRLWKTGAALDTIADGVRVRPLGEKCFEVMKHLSHKKIYSVNNEDIRFAWKLIWERLKLVVEPSSAMPLAAIFKYPEDFKDMKSIVLILCGGNVDFVDPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCR3</accession>
    <name>A0A914YCR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17221.t1">
        <property type="protein sequence ID" value="PSU_v2.g17221.t1"/>
        <property type="gene ID" value="PSU_v2.g17221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052823">
        <property type="entry name" value="SXP/RAL-2_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593:SF36">
        <property type="entry name" value="DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158855">
        <property type="entry name" value="Lipase chaperone-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SXP/RAL-2 family protein Ani s 5-like cation-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17221.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14611" checksum="3C1B9E0C45264F36" modified="2023-02-22" version="1">MPPPPPPFLEGADQSVIKQFDQLIATSGHLTDAQIDAAVDEWASKQSDDIKNKYNSFKEEMKKHQAAAEAAHQASIAKFSSEAKIADQRLSAVANNPSLSSQDKSRQIYQIMTSLPENVRQEIEKAMMGPIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE27</accession>
    <name>A0A914YE27_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat domain-containing protein 83</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mitogen-activated protein kinase organizer 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YE27"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1769.t1">
        <property type="protein sequence ID" value="PSU_v2.g1769.t1"/>
        <property type="gene ID" value="PSU_v2.g1769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1769.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33467" checksum="8C69C0231857DC70" modified="2023-02-22" version="1">MLSSGTSRNLPTTLVHSFCCNQGALRTVRFNNDGNYCLTGGVDKTVALWNPFKATLLHSYTGCGGEIRAVSSSGDNSMIISGGTDKIATIFDVESGKLLKRFRGHGSWINSVAFDDESSLAFSAGQEGIVYIWDLRDRKEIAQILDEANDAVLCIDINGSQIATGSADHRMRLYDIRQGKLSIVDAGESVTDVHITDDNECILMASMKQSIKVIDKSNGQILADYKGHSNEEFQIECGILPSKDEVVSGSEDGFVYIYDFVAMNIIAKLDHSPAKFIHSITIHPKKAALITSARDRVFVWTSDDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE49</accession>
    <name>A0A914YE49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE49"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17037.t1">
        <property type="protein sequence ID" value="PSU_v2.g17037.t1"/>
        <property type="gene ID" value="PSU_v2.g17037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17037.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25523" checksum="B20F5D86D99F123B" modified="2023-02-22" version="1">MLLCRGYIRHVLDGKQFDKKRYYFFDDSIIAYRKQIEQLHHRQSNNVVRAVTGSGTTEITYLGSPTYPHPLPTVSQQKQHSQTNFHCIPVSCGTLPEPQFISTQNSYLTGSRIPTRSAQSQPRLPSISSQHRSPFYPPPPTQASPRAPIMWPISPVLKRSCNSPQTNDYASMIHGEINSNYVSIPPLPSNNIIGNKLYSSTIPPPNNTPNSLSTNSSTALLNIAPKLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEY9</accession>
    <name>A0A914YEY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18023.t1">
        <property type="protein sequence ID" value="PSU_v2.g18023.t1"/>
        <property type="gene ID" value="PSU_v2.g18023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18023.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16207" checksum="8503218119C793C2" modified="2023-02-22" version="1">MNVENVCYHWELDYRYRINVLKQFNVYMMSDIYIEYLKPANYACGLKDKSHNIYLLDFGIARMYKKRNIQGGMEIKTPRDTVLFKGTVRFASIACHRNIEMGPKDDCESWFYLLLDLIVPKGKQTLIPFFGVGFIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGJ5</accession>
    <name>A0A914YGJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGJ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17907.t1">
        <property type="protein sequence ID" value="PSU_v2.g17907.t1"/>
        <property type="gene ID" value="PSU_v2.g17907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17907.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18939" checksum="82FB8BCED245802D" modified="2023-02-22" version="1">MEARIQECQDEIKKCDEQIPALKKNQKSFKSDLDKANAALESKKSEISTFLNRFVRDFESFKTLQSRLSDIVLDENDQAKLTSKMETFSERKNELERKKVQYETEKMNVSNKEQKVRILKDQLNKKVLQEDVATLNGELMELQEKIEELAGIEKQVGYFLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGY8</accession>
    <name>A0A914YGY8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">17S U2 SnRNP complex component HTATSF1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Within the 17S U2 SnRNP complex, interacts (via UHM region) directly with SF3B1. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with GTF2F2/RAP30 and POLR2A. Interacts with TCERG1/CA150. Interacts with (poly-ADP-ribosylated) RPA1; promoting HTATSF1 recruitment to DNA damage sites. Interacts (when phosphorylated) with TOPBP1; promoting recruitment of TOPBP1 to DNA damage sites during S-phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18056.t1">
        <property type="protein sequence ID" value="PSU_v2.g18056.t1"/>
        <property type="gene ID" value="PSU_v2.g18056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000202">
        <property type="entry name" value="HIV Tat-specific factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 22" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="24">
        <location>
            <begin position="210"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="432"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00062124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00073773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18056.t1"/>
        </source>
    </evidence>
    <sequence length="483" mass="56767" checksum="EE41B0B70C23EA3B" modified="2023-02-22" version="1">MESQTPAAATTIPTSSMSQQNSADDRRCIDNRWICLKDGDFFEFKENEWIKVDEDEIEDLNDKWNKTRPAPLAPQLHREVDGRWIYPNGEKFLEFIDSEWREVDPSQLDEIKIKYEEADPYRKVVNGIPMKFNLHLQQWLPEVEVNDDFVAMYQANYGVAIDYSKLPPSEKEIKLKELEEKQKAKEERKRKATEAGQEEGWTEISNERDTHVYVNNLPTDITDDEFIEFMGKAGVIMKDPRTNKPKIKLYRTPEGDLKGDGTCCYVRRESVELALTILDGWDLNKHKVHVEKAQFQMKGEFDPTKKKKRLTLEQKKKFMEKQNKAFEWEPEKPRNYRPPSDQTVILKNVFGLDEMIKNVTLALDLKEIIKERCERFGKIIKVVVYENHPDGIVSISYSTVEEADYCIKLLNRGIMRQREIEASNWDGKTKYNVKESAEDQKRRDQEWKTFLEDEEEQDEDIEKEKSDEKMAADDSDPQNVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH82</accession>
    <name>A0A914YH82_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoplasmic reticulum metallopeptidase 1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YH82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18148.t1">
        <property type="protein sequence ID" value="PSU_v2.g18148.t1"/>
        <property type="gene ID" value="PSU_v2.g18148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053973">
        <property type="entry name" value="ERMP1-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22248">
        <property type="entry name" value="ERMP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1-like C-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18148.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18221" checksum="D4EEB7502B0507D9" modified="2023-02-22" version="1">MIRAKRIEDDSLDFYEAKIELKSKVLDNHGRLRYEFLFKGSDQMSVIYEHPETAKSIGWRLINSPSKEFVSNSSFIFLSCGGENCGEWNIEIIFENMEKSESIEVMVSSHTLHGPKMYSNTLKKMHENIRKNREKGDWKWAMTASSWTVDLLKQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHB1</accession>
    <name>A0A914YHB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHB1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18180.t1">
        <property type="protein sequence ID" value="PSU_v2.g18180.t1"/>
        <property type="gene ID" value="PSU_v2.g18180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18180.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28685" checksum="D049B1E560BC18F7" modified="2023-02-22" version="1">MLPLRFGTPVFFTVPIPGQFFNTGPPLNARPLLQGFGNPGFRLPPQLRPPMSLNIHHQPRPQAQPQQPPKFRLAAPPKTTIFVGNISEEVETDLLQKMCEECGDVNSFRRMQGANGKPQAFGFVEFNHVEATRRALRLLNGFNIGGKPLLIKVEEKVMNQIHEYLNSLRQENGLLPLPIGTEFPTSDEERDGDIVAERRIVEMVEAVDKNLLREPDPPPPEPKKEEKKVLSSSESEDVSYIFKLYHEFNLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI68</accession>
    <name>A0A914YI68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20029.t1">
        <property type="protein sequence ID" value="PSU_v2.g20029.t1"/>
        <property type="gene ID" value="PSU_v2.g20029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20029.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28590" checksum="3C1855A7FDFC0E54" modified="2023-02-22" version="1">MSTTRNMIFIVHDIVNMSEYNIQTSKWKNFEFNRDIENYDPTQIFAQIQSATNLKKIKAMVFTIMDLCFPTIAHAYEFRLKCSEFCKSNGILYFYIPVSSIIAFSVMSKAKVMVEEGEEIIISCPSSASSQIYSNLLIRKKDHYQVIRSQTDSDLSLSQEWKKKLLKNSNPKKVILMRLSPMDSAHFLLKCSHLFENALVIREESHFASIHNVIVEKVMHVLGDKITPYDVTIQCLSKIAVLMDENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIS9</accession>
    <name>A0A914YIS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17219.t1">
        <property type="protein sequence ID" value="PSU_v2.g17219.t1"/>
        <property type="gene ID" value="PSU_v2.g17219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17219.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15613" checksum="DAA3E8289F612DCE" modified="2023-02-22" version="1">MKISILIAERLKKELDSVYEQKTCVDNELQSKIKELYALGETLHSNQTEVGKLREAEFCEAINKLERKVQELEQQLKQKIESSQHQQDVRRTTGASASSNNEFESLSREQLIHRIQREITLKDQVSLLHSYWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ84</accession>
    <name>A0A914YJ84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJ84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18900.t1">
        <property type="protein sequence ID" value="PSU_v2.g18900.t1"/>
        <property type="gene ID" value="PSU_v2.g18900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411">
        <property type="entry name" value="B3GNT1, BETA-1,3-N-ACETYLGUCOSAMINYLTRANSFERASE 1, HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47411:SF3">
        <property type="entry name" value="I-BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18900.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20177" checksum="85171FC067FF14B9" modified="2023-02-22" version="1">MAQLAQNWDNRISVALLVDSFGFTALKTYLKLHKCMKNASAKVSTHLVWKPENETCSTAFILDGLAEPSNDTEFSIEADNCNVEDHIDNGLFNHSSTELYWPNTLRNVAREGSGTELHLIADIENHFSLNASTILLEAIKNVDKKSKIAVIVRRFEYNISYDEPRTIKDLHDLCKIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK20</accession>
    <name>A0A914YK20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17654.t1">
        <property type="protein sequence ID" value="PSU_v2.g17654.t1"/>
        <property type="gene ID" value="PSU_v2.g17654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17654.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9319" checksum="7FA58F0830E8B4D3" modified="2023-02-22" version="1">MKMTPEFQSKVQSFLSTDNFQNCNHSSWLTIDELNPPHVQDIECFDKFEYGRVFFETFKSSTPNSSDECSVDRVEVVCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLP7</accession>
    <name>A0A914YLP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19833.t1">
        <property type="protein sequence ID" value="PSU_v2.g19833.t1"/>
        <property type="gene ID" value="PSU_v2.g19833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19833.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15930" checksum="710837A215E5AE0E" modified="2023-02-22" version="1">MESFSSSSSTTTSLEQQFAAIMNTPVVVVGSHENSPPFSYTAEDPSPLLQMFQNLITMNEKYVQLSLDAYNLHNPRVELPSDPLKDISTIAGKDLSNAEIVEFLKNPGPWRPSSTYDFPFDESRKRARHAWFVQNISILYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLZ5</accession>
    <name>A0A914YLZ5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19937.t1">
        <property type="protein sequence ID" value="PSU_v2.g19937.t1"/>
        <property type="gene ID" value="PSU_v2.g19937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="241"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19937.t1"/>
        </source>
    </evidence>
    <sequence length="1402" mass="156647" checksum="D41AA64C1AD83771" modified="2023-02-22" version="1">MQKETFQLPDTSKQITAVRFIAGGAQFIKDTSQLEIFNNKLYEDIDGKHGPAPFGPLDLRLGTSQRTNNCQTCGQNMVECIGHFGHINLEVPVFHVGFFRLTIKLLQCVCKECGSTLLSGTTKQKLLAQISSPNLDYLKRKALHKKIVEMSKKISNCPECDSSNGVVKKASGSVMKIAHAKYLNGTQVNIFVDENSENSSTLLNMKYELLNPEMVLSIFQRIRREDYGLVMVRNDKYMNPCDLLVTRIAVPPVCIRPSVVTDFRAGSNEDDITMKLTEIMLINDVIKKHKKDGAPTKTLTETWDHLQIQCALYINSELNGLPLEMQPKKFIRSFTQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLKIDQVGVPVQVAKILTFPEVVNKWNIEKLRQLVINGDEMHPGATHIVEGSSGRKKFLKYGDRKVAADSLRFGDVVERHLQDNDIVLFNRQPSLHKISIMAHRAKVMPHRTFRFNECACTPYNADFDGDEMNLHLPQTYEAKAEAAVLMGLKYNLITPRSGEPLIAAIQDFISAGYLMTLKDTFLQKVQVMRLAASLMDKSEKRQQRVVIPKPAIIAPIPMWTGKQIIELILNPYRKPDCVINLTTKNKSYVKNEEFCPKDGYIIIRKNKLLAGCLDKTLLGSGSKTSIFYTLLRDVSEDAAIEAMWRLARMSPVFMSMRGMTLGIGDVKPTQGVNNDKAKLLQEGYTKVDTYISEFNDGTLKPSPGRTQRETLESLILRELSAIRDYCGSSCLNNLPSHNSPLTMAVCGSKGSFINVSQMIACVGQQAISGNRPADGFPGRSLPLFDFYDDSPVAKGFVENSFFTGLIPAEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKCLEDLASNYDGTVRTSTGEIVQFIFGEDGLDPACMEAKSGAVVDFEHVLEHIKVMKPYEYEPPRNLEAMISLIDIEIKKQSKILPMKFLMDLKEFIFKKIFVASEEAKRIHMIRENDAEHIQQFKGENQAEYVARKAMTATQLGEFVDLCLAKARRAVIEPGTAVGAIAATSIGEPSTQMTLKTFHFAGVASMNITQGVPRIKEIINAVRQISTPVITVELSDPTDEVLARRVKARIEKTTLGEVSKHIEQVFMPDDCFVEILLDAKRILLLQLEVTPETIAHSIATAKLPVVVKASQVEIINSTLIIVRPPQQSAKMSYTLAMHYLKYHLANVVIKGLPNVLRCLIHADEKTGKTYNLLAEGTDFKQVMAIPNVNTSRTTFNNALVIAEVLGIEAARKSIIDEITGTMESHGITLDQRHIMLLADLMTFKGEVLGITRNGLVKMKESVFLLASFERTTDHLYEAAFYGQKDKISGVSECIITGNPISIGTGMFKVLTQGKKERTQSNRKFSFKGSVEDSEKLFMNVFRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM05</accession>
    <name>A0A914YM05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19947.t1">
        <property type="protein sequence ID" value="PSU_v2.g19947.t1"/>
        <property type="gene ID" value="PSU_v2.g19947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19947.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29772" checksum="235A895CB0D15500" modified="2023-02-22" version="1">MLPTKNAVKECKIKAAERAPNMYIEFFSSELDSNEMEIYSDLTVLYQSTWSTSTFNVLVMVEEIYMLALSMLDPQIKFQDYDLCNEGSIMAYFQYLSDNNSSQTVAKMTAPVNFMDSRRTNYFWGETSICRTKMDQKNITEMAHLIPTTKHQNDVTMKPGEGINGINGTVWLIIGGTITIMLMLSMVIIGRILWNKFTSERRMSSVLKGKSDSFISVMKTKEEYWKMLLNVDNVIINFEEVIGEGSKAIVYKGKQHGREGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMV7</accession>
    <name>A0A914YMV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20925.t1">
        <property type="protein sequence ID" value="PSU_v2.g20925.t1"/>
        <property type="gene ID" value="PSU_v2.g20925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="3"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20925.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47088" checksum="9FA6649A01677730" modified="2023-02-22" version="1">MKGNIGPGCLSLPAAFKQAGVWMGFGLVFVFGILTKLSMQQLVECSQYLSRKKDDIPLDYGNLMLEACDNSFEWIKKYKFFAKFTVNATIVALQIGICGVYFVFISEHLKELTEQYSNFEAPLTTYLLLLFVPICLVSFVRTLKGIAVFSTIGNIFMTICLVYVFQYLIRTPHNLAQLPWITDFNGIMTASGSILYAFEGQAILLPMENKLKYPEDMLSTCGVLSTGMSLITIIFAACGFFGFITYGHDVKGSITLNLPNNVEFSIVKLCLTMVVFLSFAIQFFVVVDLSWPTVRQYLSTKFSAKILSTPYEYLYRIFCVFIAMSLAIGIPNLEEIIPLIGVTAGIFMAFIYPSLIDTMTFLPILLKKYEKVGITLSQKRSIMFSIIYRITRNMSLIIIAIFACGGGLYSTILELIQGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNI0</accession>
    <name>A0A914YNI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNI0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20523.t1">
        <property type="protein sequence ID" value="PSU_v2.g20523.t1"/>
        <property type="gene ID" value="PSU_v2.g20523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20523.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7237" checksum="55C7EE5AE91FBA89" modified="2023-02-22" version="1">MTQLPGLPGFPTGPFVGVNPIPELPPIPESRLDGKYDNDGNFVPNSTPKPDKQILENRVSIYFKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPS5</accession>
    <name>A0A914YPS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPS5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2102.t1">
        <property type="protein sequence ID" value="PSU_v2.g2102.t1"/>
        <property type="gene ID" value="PSU_v2.g2102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2102.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18472" checksum="A18236FCB7EAFDAB" modified="2023-02-22" version="1">MKEHFNLGLRLRHRYIKQHPLVSPRFRSKEISIRSTGYNRTIASALTNFVSFYFTGNIKGKDYPNSIFWPAYFTPVPVYSVPWKDEDLFNVFKCPRALQMNALIPQTPEFAAFVAAYQSLFTILNNNSGIVISNSSSYSNLNNAYRICDCILCETLFLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ19</accession>
    <name>A0A914YQ19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21558.t1">
        <property type="protein sequence ID" value="PSU_v2.g21558.t1"/>
        <property type="gene ID" value="PSU_v2.g21558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21558.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11220" checksum="5194B788C78CFFA0" modified="2023-02-22" version="1">MLSRTGQAAVMILRAGEHSQARLIQTSSVALRDKPITEQMKEGANNLAEKAKEKVEEYNIIHITDKVKDSAQQVKEKAKKYTDKAGQKIERAGEDIQRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ44</accession>
    <name>A0A914YQ44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arginyl-tRNA synthetase catalytic core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQ44"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2942.t1">
        <property type="protein sequence ID" value="PSU_v2.g2942.t1"/>
        <property type="gene ID" value="PSU_v2.g2942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl-tRNA synthetase catalytic core" evidence="2">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2942.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19191" checksum="1EEDD37FCFF5197A" modified="2023-02-22" version="1">MEERFFFASGFSVPLTIVKSDGGYTYDTSDFAAIKQRIFEEKADWIIYVVDSGQSLHLETVFGAAKDLEWYKVEEKRIEHVGFGVVLGEDKKKFKTRSGKTVRLNDLLDEGIKRSEDKLVEKGRQNVLTQEEFNAAKEAVAYGCIKYADLSHTRQNDYVFSFDRVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR09</accession>
    <name>A0A914YR09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR09"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21514.t1">
        <property type="protein sequence ID" value="PSU_v2.g21514.t1"/>
        <property type="gene ID" value="PSU_v2.g21514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21514.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28072" checksum="3FE13B8E50DD701D" modified="2023-02-22" version="1">MFQECKNKRAQKFKEWSQALLNHLWYSVSSAKGDGALCQEYAVSALLHAIDIHEWPTGPMSAVLHDAQAAVLGVDEEEILKNDPVDLPGKLIKELEFQKYLCCGHSNPVVQRVEKSGLDPNSKSYQVFQKTFTSDSFLNDVKNLSPDFATSALEGFQGLVTNKYRSKNSYFDPKSFEEKTMLAVLHYNNNRIDELEGRRKVRKVITRSAKHRGGEMVKKNLKTPTDYTWKLQLYQRYRSRFENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRE7</accession>
    <name>A0A914YRE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRE7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2226.t1">
        <property type="protein sequence ID" value="PSU_v2.g2226.t1"/>
        <property type="gene ID" value="PSU_v2.g2226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000070">
        <property type="entry name" value="Putative carboxypeptidase suro-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF54">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="7">
        <location>
            <begin position="83"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="513"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2226.t1"/>
        </source>
    </evidence>
    <sequence length="550" mass="63198" checksum="91171C28255DE0A5" modified="2023-02-22" version="1">MVGPELTEATEKLLSDKGIQFKVTVDDVQKKIIEKEKAPTATTSFLSKQNLTNLDPLLASFFSKRSKDEIYTSRNRAKYRFGEYHSYEEMITWMEEIQRQYPKIAKVFTLGSSVEGRAIKGIKLGSPIESSTKRAVWIDGGIHAREWAAIHTALYFIEQLVANYQVDPQITAYLDNLNFYITPVANPDGFEYSRSDVTPQTRFWRKNRGGITCTKDRWHRERCCGGIDLNRNFDFHFGETGSSNDVCSDIYQGASAFSEPESRAIRDKLFSAELWGKVDAFITLHTYSQMWIHPYNHERRSFPADIDDLQEVGRRGVDAIEAMYGTKFRFGTGADILYPSSGGSDDWAKAKANIKYVYLLELRPGEEQWDGFLLDRKQLIPTGRETWEGVKAVFDAVLKKARLSAPPPTTPRPTTSRPTTTTPKLTTPRFTTAQVVTLVTRPAIRSRIQNNNNGNSNLRSTLHERFNRLRQQQLKARREYETRMAQQREYERQQKIQQQIQQQSQFVSMSNACFDRSRWCEAWIQSSPGICISSTIYMQKDCARSCRFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS64</accession>
    <name>A0A914YS64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3570.t1">
        <property type="protein sequence ID" value="PSU_v2.g3570.t1"/>
        <property type="gene ID" value="PSU_v2.g3570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3570.t1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47554" checksum="AEAC67437118B2C8" modified="2023-02-22" version="1">MDTARGNSGRGRGRGARGGRGRGGARGRGRGRGGGNFNNQDQGHRVGDRIVLSSVDAGFAPPSPPAKSSYRSRPIQTGTEEILGNIVEHENDLPHSHPKKQFTKQKEFKEIVADTAAATLSDDDIDMSELLETSPDGLITQLRGRPTIKKLDSKPEANGYKDIWDRGQYNKVTRVIGDYPKAKDRCYIVRPIPRAQPVHYMNKFARQKLSLAEPHFRKIKPQPPMTFTSQAVYQQFRGTEACSKVAGHVLADILENPHFFRKLFSIQIPNSLKAFSIDNDSADDIMIAKQNVMKNNAENEAAAAAVTMKSQPLKMKKPRYHCLTQFSSDQPFGKLQLLKSGRVVLRVGNRIFDVCTSTQNHDTHVGAIFEHDSTEEKSRTSAPLNGNQAANNHHQDNLFLLGKIEHFFTAYYDYQKILKELDSANSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSI1</accession>
    <name>A0A914YSI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSI1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2970.t1">
        <property type="protein sequence ID" value="PSU_v2.g2970.t1"/>
        <property type="gene ID" value="PSU_v2.g2970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="36"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2970.t1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44271" checksum="AC5D49F41E1C9829" modified="2023-02-22" version="1">MDDDPLNASPPGSHQDDASTTTTTSGRNRPMTFNELLIQEVRSHPELYDQQHRVCTDNGERNLIWESIAARIDDSVSGEFAKKRWLQMRDRYRKELKSALRSGVIPKWPYFEKLSWLDPYLKDNKPGSISSSFIGHTFSSSTSNLQNDEESAATGEQGGELMDFTNYAANLSANTLLENIMAVSGGSFTNHHHHQMSDIKNLSGEFSPDSAVASTSEDGDIASSHRLSSSQPSDRPDSTETPTTIETSSSHALLSSLNSFNNHTAAGLLMKLEAMNNVAAVAAVSSEHQKLLDQKLLNAFRQSNSSSPTRSNSKTRHPPYLVRRGGGLKVKQPSTGKHKQSSSDFLAASPRSLSESSMNEKTLRKLDKECLEEFFSKEWANDEDMLFARLVNNKKVINSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSL0</accession>
    <name>A0A914YSL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20398.t1">
        <property type="protein sequence ID" value="PSU_v2.g20398.t1"/>
        <property type="gene ID" value="PSU_v2.g20398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20398.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15308" checksum="526E4CF56AB91773" modified="2023-02-22" version="1">MIAASFGHVSIIKKLVKYSEENAETSDAKNIIAKKIGLHLADEGGFTALHYAVFYGHHPTIEYLLQLGSDPNVPDIEGMTPTLMACVDQFQEESLPALIKAGGSLYHCNHDGQNGFDIAKRKSLLSFQTHKPEGTLYGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUG2</accession>
    <name>A0A914YUG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA replication ATP-dependent helicase/nuclease DNA2</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUG2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21118.t1">
        <property type="protein sequence ID" value="PSU_v2.g21118.t1"/>
        <property type="gene ID" value="PSU_v2.g21118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21118.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41338" checksum="1FCE4BAD95A0F43D" modified="2023-02-22" version="1">MTLGIVCHELFQSVLRRQPKIVSPAWLLAEFRRAILPKLILDLVILDVTIEQFEAQLKPYLTNITTWMRSFLPAPFGKNTPLSDGNKISDIEDIEMNIWSNGIGIKGKIDVALRTAKNRVIPLELKTGKSSYSIDHHAQVLMYAVLLSELDDGKLDSGVLLYLKDGTETIVTPSVADLKGILQTRNGMATFSRALNIEFFPEPKVETRFCGKCQFSRHCTVLQKLATTKSMAISEEMEKFTNNSTFHLTENELEYSKQWLEWTFMEWKADRKRKNMDGIFMETPKQRESNGTCLSNVILEKYEKKEDGIIWFTFVKQSKEKLPSNVLEMSELVVISTDEIVAVQTGVVIDRQGTEVFINNTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUH6</accession>
    <name>A0A914YUH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUH6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21135.t1">
        <property type="protein sequence ID" value="PSU_v2.g21135.t1"/>
        <property type="gene ID" value="PSU_v2.g21135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21135.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38434" checksum="0A2B8E60AFD5B1C8" modified="2023-02-22" version="1">MEMISLVVDVNIKSCIGKVLFCYESSKIENEAAKLCFKSGYCGFQLIGTENEIESVATKVVKKFLEDCMPIEMKYSDAHFCGIGLVPSCNPEIDAEGRIKIEVSDVGCPVTIKNAQIYVPPATTSSTTSSILDSDSASNAGLQWYYWILIVFGILLIVFCGVGIWICVWKKNILSDCKKKSAKIVPVESIVSTTVTQEIKTVTKEEKMKEEPKLKVESKPKTPKPSTEPASAPAPAPTGKPKEIPKAVEKPLKKEAVKEKKKSKSKTPSTESYSAPFCLLPFPAQPFEPEPEPVQEPPAKKRPRNEEGRRSRHMDSLELADDRINGIDTITKIEMERRKRSRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUM5</accession>
    <name>A0A914YUM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4323.t1">
        <property type="protein sequence ID" value="PSU_v2.g4323.t1"/>
        <property type="gene ID" value="PSU_v2.g4323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4323.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21805" checksum="EE90087DC707D7C7" modified="2023-02-22" version="1">MSDLNVNHRDSKHTCFWNFIHVKTATKFVCSLALLGYLLSTIGLFLHNYKTWHHYIEIVRVILGTFSFANVFAGIHLKAPRCLLICLVWIASRMIFHTAQILLCLIAYFPESPLEHVQRHLMGSFLRDRNITKSEHFIRFVAMLVLYIVIFDLIYKCYKYIAEKAATSDKEILPHSTVLISQESKTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUY7</accession>
    <name>A0A914YUY7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914YUY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3959.t1">
        <property type="protein sequence ID" value="PSU_v2.g3959.t1"/>
        <property type="gene ID" value="PSU_v2.g3959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3959.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="36320" checksum="E02A54D7705D7639" modified="2023-02-22" version="1">MAENFNDTWLKNYYQHFYPVKSVLKWLSYGKKPSEYLQYREFAFILKDDVHYRYLTFSEAGQFRKELERVIPHKVDLGAVYNHPPKDRLKYRDFKAEERELVFDIDLTDYDEIRKCCSGANVCQSCWRWMTIAVKVLDKLLRNHFGFQKILWVFSGRRGIHCWVADESARKLDNTGRGAVADYLSLIAGTKKVEVDPQFTHPMMEDAYLEIMNCGEIDNLVIEQKWFDSSENWLPILESCKDQDMREALNDGFEKLTTPELRWKLLKRRFDEQTRETLDERDRPDIPPSAKIFLNHLFYNTLIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV03</accession>
    <name>A0A914YV03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YV03"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4436.t1">
        <property type="protein sequence ID" value="PSU_v2.g4436.t1"/>
        <property type="gene ID" value="PSU_v2.g4436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4436.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22951" checksum="C8407DE5E934396C" modified="2023-02-22" version="1">MQTTRPDIISLSSNNALSLMIGVEVFENYKQNFKKIFDNNLSDGNEKVLTVKTSIDNQKRCEIALYEGSSNNIEENVYIGSVNISDLPPGKAGDIKVDVRFKINKNGILSATAGHNNNYIEYFNTSLKSSSSEYENTVENDKSDKNDKNDINAIGIDFGNTTCLAGVKQKHGFEIVALENTGERELLSYVGYDEKHVKCGKICIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWM9</accession>
    <name>A0A914YWM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2487.t1">
        <property type="protein sequence ID" value="PSU_v2.g2487.t1"/>
        <property type="gene ID" value="PSU_v2.g2487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="82"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2487.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20976" checksum="0D2DD04DDBD67F7A" modified="2023-02-22" version="1">MNSSQPGSSTNNENSKPIAQRGTSNLSLEQRQALLSRLANPEGPRNIQKRVRERTLQAICINGSAPMTKEKPILEQVDPIGKKITEYIKKKTLVTIKLRNKNHFEIPNRTIMGIILAADHHWNLMITEADEAYLPACRLGVVQSYPDQMFEGTVYDRVEGQKRLLQRSLESTIIMGHNIVYISAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXT1</accession>
    <name>A0A914YXT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXT1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2890.t1">
        <property type="protein sequence ID" value="PSU_v2.g2890.t1"/>
        <property type="gene ID" value="PSU_v2.g2890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2890.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14083" checksum="36FBBA5C67FD708E" modified="2023-02-22" version="1">MILFSSVDAVFHLWNAIPNSSKTECQTFACLVSNESGQWYTVIRITVCIANMLVGIALICLVKIKTVSKSAILKFWGFGVSKYVGPYSLLVTTINSSFCGFVYFKVMKKSIKKSSIHASIAPVMLATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZH2</accession>
    <name>A0A914YZH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5496.t1">
        <property type="protein sequence ID" value="PSU_v2.g5496.t1"/>
        <property type="gene ID" value="PSU_v2.g5496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5496.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14314" checksum="83F1948E943554FD" modified="2023-02-22" version="1">MKGDLTYMFNQKDAKNGYSLVEQFRDTRPPDIAAHNRKYIKYSQRYKIPEEVAKSCVLSSIKKDKMKKKRLEERFNLRGTLYDKKPGESKPKDKSLFSADDFNNVADFSTNNVLQQKIKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1M1</accession>
    <name>A0A914Z1M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1M1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g579.t1">
        <property type="protein sequence ID" value="PSU_v2.g579.t1"/>
        <property type="gene ID" value="PSU_v2.g579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g579.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19462" checksum="03608C8F026B2A69" modified="2023-02-22" version="1">MTIINKIGGRMTFTLYGFISGIATILLPLCAKYSFAAVVFVRFLQGVGYGMSFVSVGYVSSSWSPMESRGLFLTVLTMFYQISSLTAAPSAGLFCTSEYGWQGMYFLQGISTIIVFSIFFLIYTDRPRTNKFVSETEASYIEGPEPMLLNDRELPTIPYYEALTDPAIIGTLIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Q1</accession>
    <name>A0A914Z1Q1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Q1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6288.t1">
        <property type="protein sequence ID" value="PSU_v2.g6288.t1"/>
        <property type="gene ID" value="PSU_v2.g6288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6288.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28875" checksum="A26D79A4A404AD23" modified="2023-02-22" version="1">MEKTHHRILVKFKKDHLQIQSSNVIQSALTPLVGMGVVPLERLFPLILGSGIGASFTGILTAFSADPGQLKEFVYIKISYKYIRFNYCQILAPFKMAFCQTIYNLFGMLIFFPLPFIRRIPIRGAMIIGEKTAKYRWLALFYIVVVFFLIPIYLLTISFFPKPFMIAAIILTVIFWSTIFLINFLQSHFPKKLPKFLQNWEFLPEWLHSCKPYDEFLTKRFSKRNQNETGRLTTVEKLIRLTIQTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1W5</accession>
    <name>A0A914Z1W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1W5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6353.t1">
        <property type="protein sequence ID" value="PSU_v2.g6353.t1"/>
        <property type="gene ID" value="PSU_v2.g6353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35373:SF3">
        <property type="entry name" value="ACTIVATOR OF HSP90 ATPASE HOMOLOG 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35373">
        <property type="entry name" value="PROTEIN CBG16894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6353.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17864" checksum="76A2EDFD525C1F6A" modified="2023-02-22" version="1">MRNVLYKDKFVEVYCDKIVIKTYVFPIATSKHVSIHELRCIYYKKQQAWADILVTKGWGMTLYPVWWACDLRRHFPKNSQHFNVILDTGSVMKQGFSVVDIHKFLKALRPITNAPFENRFPKFFEHRILPQPICDGAADSEGLLEEENKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z299</accession>
    <name>A0A914Z299_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z299"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4378.t1">
        <property type="protein sequence ID" value="PSU_v2.g4378.t1"/>
        <property type="gene ID" value="PSU_v2.g4378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037575695" evidence="2">
        <location>
            <begin position="19"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4378.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="20911" checksum="EA2915DCDD50953A" modified="2023-02-22" version="1">MIRICGALLFLTIAVVNAIELPPGLRPAKAVGEIEKPIIPGVNDPQPETPANVRTPPNLSLRSRMIAALNSPEEKSDKSHEAERRRHPTAEEVAAAAAKAPLVFQKGVKKQAIVKPQKTVPRVTQAPPAGKNYGVNTIVQTNLVDSKGRIMKGVNVVPIRVGPSSSAVKNSRASASRVEAEDDKVVPIEFGSASSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2B0</accession>
    <name>A0A914Z2B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2B0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6499.t1">
        <property type="protein sequence ID" value="PSU_v2.g6499.t1"/>
        <property type="gene ID" value="PSU_v2.g6499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6499.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26545" checksum="70407C4D072DAAC4" modified="2023-02-22" version="1">MFFRKYEVLFIDYRPVSPNYALMANLENPFNISDYGIVNDFYFYEGWKWQHFQHDIAIIEFPEGTELGEPVLLAKNYEEGDNDIGINLGYGDTDPNHEAVKVPNQLMQINMPIFPKADCKSNDAEHPVICAGNSTHRSDHGDSGGPLFFNAADGKQYQIGITHDGALKNGTDDETFSELTVYLRVSAYCDWIEEKTKGKQNVLKLAELQHQIKIHKFQKMVKNLMYLQILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2Q3</accession>
    <name>A0A914Z2Q3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2Q3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4536.t1">
        <property type="protein sequence ID" value="PSU_v2.g4536.t1"/>
        <property type="gene ID" value="PSU_v2.g4536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4536.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18986" checksum="E505CF93EC16A409" modified="2023-02-22" version="1">MNLEIIKLTSNELGYVACICQSCLYRPAFDVLELRFDTNITVSLEEDERDSHLIVHGNPIENLNITITRISDNETETSLLTSKKTSFFNDSLLIRFQQEHSHFFVRYYSLIVQECILCPPRLSSHIDGDYLIEICRIKIGDCALAKGYLDHPLYEVCFFFLHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3X5</accession>
    <name>A0A914Z3X5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3X5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7402.t1">
        <property type="protein sequence ID" value="PSU_v2.g7402.t1"/>
        <property type="gene ID" value="PSU_v2.g7402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037680181" evidence="1">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7402.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14220" checksum="D52FA2BD54A66CAE" modified="2023-02-22" version="1">MKVLSLFLLFFGIIKFVGSEPIVADNYHGNLRRWTIKADGKMHIGLHLLKESVKLTFPKATRFNELLSEIKLYSPNERGKCKDTKSLNFNLVIAPKNDIHGEIKVVSRRTVANLFETCDGKFINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5F7</accession>
    <name>A0A914Z5F7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysosomal acid phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5F7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7912.t1">
        <property type="protein sequence ID" value="PSU_v2.g7912.t1"/>
        <property type="gene ID" value="PSU_v2.g7912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7912.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48007" checksum="B4DFD795611A8D50" modified="2023-02-22" version="1">MNIYGAQELEHADTTTLRLVHVIWRHGDRTPSILLPTDPTNGINSWPLGLGELTKKGIQQEFKLGKFLRKRYDGFLSQDYSPFEVYVRSSDYNRTLASGQAVLSGIFPIHGEELWVPIPVHTVPKPLDSLLYDRVLCPIADAERQMIYSSNPEILKISKKNENMLRFLAEKSGATKIPLPLREIWFIFDPLFAISCHNESHKLPDWVNSTVQKEIWRLYDISSNFMYHTDLLKRLRGGPLLKDILNRMQSRISGILDKRLKFYAFSGHDTSISALLNAFGVAINVFPHYSTALFVELHEIGNEFVVKLFYKSQTDSSFVEPLEIPGCEKSCTIEKLFALRKHVIPDDWEVECGLKHWYSFTSEFYLLIICFLSLLCAILVGCLLNTKMVHKRRRNAFELKSTPSGAHLLTGDDEDIDAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6K9</accession>
    <name>A0A914Z6K9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6K9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7966.t1">
        <property type="protein sequence ID" value="PSU_v2.g7966.t1"/>
        <property type="gene ID" value="PSU_v2.g7966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF246">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TNNI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="483"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="793"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7966.t1"/>
        </source>
    </evidence>
    <sequence length="935" mass="103920" checksum="E4EEEAEDEB4EB87C" modified="2023-02-22" version="1">MGNYKSRPSLACADEIKKRISESYAIIRSRLNDESKTRLEILSPLQSLCFHENVQKLRDYLNENFICLDEKSSPKELSLLHLICIGPSSSEENDHDVVETLLKGGTEPNVFLPIIPPPLHLAAMCGNAEIINTLVKYGANLHTLDFAHFSALHCATYSGNDQAVRALLASGADPNCSGGVHDRPLHIAASKTQFSIVNILLEAGGDPSLTDDEGNTALHFAAKMGHSTIINHLLKKCEKNKRELVMQANIYGDTPMHTACYTGRLDAAKQILSAAGSSILNKENMFSETPFLAACTAGKSIELIAFLLKQPGANANYQGKDGHTALHSACYHGHLRVVQYLLEHGADQSLTAKAVENSLIHGPLPPENGYSTISSMFTLRRLDSGGSLGGESSISSSHSIADEQTPILWAYEKGHDQIVALLKHYANKKLDSDVCSEYSSGDSSYTPLPSPIGRLRSITKEKSDILLLRAKLKSSYHLSLPDIELRNIIGSGSFGKVYQGIYKGKSVAVKRYKAVAFGSKTEVDMFCREVSILSRLNHPNVIAFVGACLDDPSQFAIITNFIAGGSLYNLLHVEKRVFEMSFKLCIGVDVARGMRYLHELIREPVIHRDLNSHNILLHNNGRAVVADFGESRFMTNHEEDNMTKQPGNLRWMAPEVFTQSCRYDQKVDVFSYALVIWEIHTAELPFSNLKPAAAAAEMAYKKSRPELPKEHTPQFPPHILKMINDSWNPNPDLRPEFSQILNDLERYAIPDDQRNFNIGDSRSVRNISESEEEPEFSIDQMTTVSRLKDQWEQQTVGNSDNKRFTSGRNDSESESVYMVSNGVIRNNRSHKTIDTLRNQLDNHGYVSHGARAINAAKTATQHRDSFILARSAKISERQSVFKENDQSIPCNFTNVVINGSSKYSNQENDIIQDDIVEQEKRQKYGSVETLTASQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z765</accession>
    <name>A0A914Z765_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch-like protein 20</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z765"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6092.t1">
        <property type="protein sequence ID" value="PSU_v2.g6092.t1"/>
        <property type="gene ID" value="PSU_v2.g6092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6092.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22150" checksum="D7D88C6F709CC4C8" modified="2023-02-22" version="1">MIKEDVQCRDLVDEAKNFLLLPTDRPTNVRFQPRVPARFGQLLFAVGGWCSGDALAETECMDTRTGQWRNVKSMSKRRCGVGVAVLDKQIFALGGHDGSKYLKCVERYEPFRNQWSSDVKPTSTSRTSVGVAVLDGFLYAIGGQDGVSCLDVVEKYDPNINQWTKVASMNSRRLGVSCSVLNGSLYAIGGADGQSPLDSVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7A5</accession>
    <name>A0A914Z7A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7A5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7789.t1">
        <property type="protein sequence ID" value="PSU_v2.g7789.t1"/>
        <property type="gene ID" value="PSU_v2.g7789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7789.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30639" checksum="80278339ED7AD8CE" modified="2023-02-22" version="1">MKDEVKKEVELYLDDQHIDKIYNALVKVIGKKHRVGFITVLYSTLVMKYEMEENVLNTLQYIHPAVQEISILLVPIHYSIHYTLAVFNLDKKEVWYFDSLFSRSRPPYKRIKTALERDLKIKFKEISKTLCQKLINKQIDGYNCGVHICRIAEEIFFNGSSQRLTPFVIEEERARTRDIYDGICDPSWNGQWFPQLQTPCIADASPSPSFSETSELSTTNDFDMTDTTISDSARSTTESPNSPISSDENAVITHEHIEYLIGSLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7J0</accession>
    <name>A0A914Z7J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7841.t1">
        <property type="protein sequence ID" value="PSU_v2.g7841.t1"/>
        <property type="gene ID" value="PSU_v2.g7841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7841.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31169" checksum="AE5C917A02916287" modified="2023-02-22" version="1">MRPAEDANETGIEFISPEEAVDQIYLPHQVTALEYDKLNIKSEQIDNFVKNCIQRVHQDVLYLPSSCILNGAELPCLTNVKLLATVLGKDGNVILAVFNLTEKCLWQFYTQSSKYYSEITKLKQIIGQKIGINEFTVQRNRNADKLVNSRELFKSKTDFFNDGIRIIVNIEQLYLTGWVKVIDHFDVAAARQRISDLYKFSTNKESNADIILQAHSGTSAGLSEDLSTDNATRALLEETLEQEIIDTNLSMGGHDLDLYSHNFNYDYNNMNASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7W2</accession>
    <name>A0A914Z7W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Saccharopine dehydrogenase (NAD(+), L-glutamate-forming)</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7W2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7954.t1">
        <property type="protein sequence ID" value="PSU_v2.g7954.t1"/>
        <property type="gene ID" value="PSU_v2.g7954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000087">
        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="202"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7954.t1"/>
        </source>
    </evidence>
    <sequence length="938" mass="104230" checksum="7C63690D27E787DA" modified="2023-02-22" version="1">MLFKRQRLTVECFKLTARRASAYAGRGTPCLGIRRETINAWERRAPLAPGHVKKLTKNGIKVLIQPSNRRAFPIQDYISAGATVQEDLSPAQLILSVKQVPIEQLIPNKTYAFFSHTIKAQQDNMDMLDTILHRKIRLIDYEKIVNDDGKRLVMFGKWAGYAGFIDILHGLGLRLLALGHHTPFLHIALAHNYSDSHMAINAVRDCGYEIALNRLPRSLGPLVFVFTGSGNVSQGAQELFEHLPHEFVDATTLPQVAQKGQLNKIYGCVVTRQDHMIRKAGGRYDKEEFTKHPERYVSKFASEIAPYASVIVNGVYWGVNTPRLITIPDTKHLLTPKSHRLDVPGCPSLPHRLIAICDISADPGGSIEFMQDCTTIDKPFNIYDADFNKTTDSFDIPSGCLVCSIDNMPAQMPVEATEQFGNLILPYVVDMLNCSTDQNFNKLQCRDEIKRAIITSDGELTPNYKYIADLRLEQNTSHHKAKIMASGNKRVLLLGAGMVSDPVANYYSKQEKVNLTVATDSQMDGQRLSNVGDNINSVVVDVNKEPDVINDLIAKHDLVISLLPYTHHAGIAKLCIKNKTNMVTSSYISPELQALDEEAQRAEITVMNESGLDPGIDHMLAAEVFDRVHDAGGKITSFISFCGGLPAPEASDNALRYKFSWSPKGVLLALMNPARYLKNGKIVDIKGEGGVLDDIYPIDFMPGFNLLGYANRDSTKYASIYGIEGECKTLLRGTLRYEGFVEAIKALRTVGLLSHDRKDVLNPMQGPDLTWKQITAALMNQNMDVFPDQLRNVVAEKLGKGKKREIAALEELGLFSDVVAERHSNPLDTLVPHLAKQLAYEKGERDIVILNHDIIAQKSSGIKEKHRISLVAYGEPNGFSAMARTVGYTTAIVSHMVLNGEIQRKGMIRPIFKEVYRPALRRLQDFGITATTKTTTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9G1</accession>
    <name>A0A914Z9G1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-myc promoter-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g8963.t1">
        <property type="protein sequence ID" value="PSU_v2.g8963.t1"/>
        <property type="gene ID" value="PSU_v2.g8963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MABP" evidence="5">
        <location>
            <begin position="43"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="192"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="823"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1078"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="957"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8963.t1"/>
        </source>
    </evidence>
    <sequence length="1428" mass="162097" checksum="6B2D7E8D11D2A673" modified="2023-02-22" version="1">MENLEDEENRRIFEHFIVAGLSENPEEFTPLEHECGTRPNEALAPITDIAVIFPGHGEKVPAGFTCIETTPSGYPADMNHGSIRTHSAFLCYKRGYHKPALVDIGIMDEGKKERPMEDSTVIQYTPDGRLANVSNTSSPLYFTYRRCKVTGPPHQLVITNIVVVLTSKNEVPPHTFFKIDKNLNKAVVGSDVFVCYKKAQSCCRRIAFKPAVLDCFPKTNLKTVLAQNVPMFCLPMGAVIESWSAKSGAPEQLFSTCVLTDAVGTKCYGASLTFYEKYTKELTPHQKELLSFDIDSKSEGDEASDSSTSSPPKEDSPEQLFFMNKSICIVSRHPFFECFRRFLYYVYLVSAQFTKQKIPIERYMSHLYYEVSFPTPLRPRVLVQLGDEMISFENHDDSQVPLSGAQFTEVLKCLGADTFIYAMSLALLEQKILIHSLRPWLLTVVSETICALMFPFYWQCPYIPQCPLALAGVLQAPLPFIAGVDSRYFDLYEDPPGDVTCLDLDTSTVRHSINKKLIKQAALPKRSLKHLKASLEKVLENLRYDDRNSEKQRRQKPSDTPDEQQQLRKASYELTIREAFLRFMCSLMAGYSSFLKPIKSYPHAKNITDISARFDLEGFLKTRDRASTEFYQKFSETQSFIRFIEERSFMSDKVVYNAFFDDCIRKFMTKGTPLNLLDRDAYSVNHTIVVQPPFMLDAKHAEAEYTYNGFPNHFDHELFEVQEIKDVSDSKVAEHVQGSPYPSKLRYSAIRTKQEIRTSIEVANKWTQNYPILWPRIVLFYAYSLWFLQLPSLLHVAKNKLKILRLAMTVLSRLNRSLVPLLDQIPFRLLMQLCGEYGYPHLAAEVLREMQRLNVEPNAITYAIYHRAVMEGEWPSEARLNAIAAWKRLRYRLEGCVRFAAVRRDPNFILHSNNVQNLPQNLDPTYSIENMSALSVDDSAINPSIPSTPEPDTVSRTSRETKDGEEKALEEQPYVITTYPLGPRKDSKDSAQNVHNNADPLFGGESETTDEGISKASSSTMSPSREQFLREHSVSPFAKDIASLDGRLTDRRKSSKQGASSWFKKLASPVVSNLMRSQTTDDIKTNEPSSTGGSSNELVPPSAITMSPSFSSLFSQVRKQALKGYDAVSQHGNVLLKKSGVNSLVNEVKNLNKSYSKDHSFIANSSMNEESMLNGTTVYQDHFDSTDPAFQLDTGTTGAILMMDYWMQDLIEDNPFKKEDDSYLIGKKKHMLKALSVLIYLDATICSCTTCPRCNRSIYDEELISGWSVDDSNLNTLCPFCNHGFAPSLKVKLEQRVEAVPQSYYTPLMSKSYTADDFDPDKVKVGSETLSVPFVSALVLRREIETLLASDILALADPSLRTSHPVIFWNLIYYLRRLEIPTHLYTWIAKNVQIRCVYDFPEQHLNKKIVPLYITNHALLVSRLRKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9V3</accession>
    <name>A0A914Z9V3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9V3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8702.t1">
        <property type="protein sequence ID" value="PSU_v2.g8702.t1"/>
        <property type="gene ID" value="PSU_v2.g8702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8702.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8626" checksum="8C43270556B131AA" modified="2023-02-22" version="1">MTSLSDGAKQLATQMKIIHDNMSLTPIQERDQIKALFDGASDEIKKELKSAKSQFMAGMMGPGGPMGGPHGNHHFTTPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAC7</accession>
    <name>A0A914ZAC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal lipase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8738.t1">
        <property type="protein sequence ID" value="PSU_v2.g8738.t1"/>
        <property type="gene ID" value="PSU_v2.g8738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8738.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29513" checksum="1BED27B6BD31E884" modified="2023-02-22" version="1">MAASAYSEHPELCVKDNYNQSEFKRRIKVNCDTLKNDHCVAFTAVSHSNKAIIISFRGSEDLEGIMEIIDVISIPPTAEFYGKAKVNHYFYTAFNDLWTSGIKDDFLSLKNKNPNYELWITGHSLGGAMASLAAATVATTNLFPLDKIKLITFGEPRIGDKTYAELHDSLISYAYRIIHHHDIFPHEPPSWIYGYQHHKSEVWYDNDMAVGDSYIECDEDESKKCSESTVNLNPMDHQSYYNVKVIFANDGCAGFNPYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAD0</accession>
    <name>A0A914ZAD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAD0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9614.t1">
        <property type="protein sequence ID" value="PSU_v2.g9614.t1"/>
        <property type="gene ID" value="PSU_v2.g9614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037366449" evidence="1">
        <location>
            <begin position="18"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="176"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9614.t1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36179" checksum="A35B78A35BDE7078" modified="2023-02-22" version="1">MSSTKLLLFLIFNFISATTTTRSPKDYLFIEDPDVDPSKYIVLKNLSKPMPSNTVTTTVIPEKFERNERQIPMILPLNGLSGLQGLGGLSSGFNYQMGSCDKLKMYLAMVGQAHTIETTQIADQCIPKVKYTVKSGPNGVSQIVNDDGDYKNKGSDKGVLCEFSSIEKCPEGYELFRHSCYKYFDQKADFPEAKSACEQQEGWLPKIRDDEVNRYIASIAFRNKNSRTWIGASGSGEDWKEVDDKQSLVIYFRWLVYNLSKKAKNAVIMTDIQRENSKWFGYWEDTSEETKHSYICAVKPTIGTPNLELIPEYSDTFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB34</accession>
    <name>A0A914ZB34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HSF-type DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB34"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7462.t1">
        <property type="protein sequence ID" value="PSU_v2.g7462.t1"/>
        <property type="gene ID" value="PSU_v2.g7462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="48"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7462.t1"/>
        </source>
    </evidence>
    <sequence length="520" mass="59020" checksum="5014BBAA18619B75" modified="2023-02-22" version="1">MSNTAQISSKSATSMPINTQQIPQQPELDGTLSAPPPQQQTILKEDDKMPLFLIKLWNIVEDPTYYDVIRWDESGYSFHILDPYSFCRNVLPQYFKHNNLNSLIRQLNMYGFRKMTPIERTSLARLESDQDHLEFSHPCFVRDHPELLTQIKRKTPTTRREDAAASAQPSKDLSNVLEEMRGLRERQKTMEDRMNELVTDNNAMWQQMTSMRAAHAKQQQIVNKLVQFLVTLVQPKRLPKRHLLAIDEFASPKRARTSETADNNGISSQSLQTIQQSNLNDILDHLMKEISKSNAELNLPSTRNGPIISDVTDELDHLSTTGVQMNQGNFISQRSNNSPIIGGYDPNAYGYQNQLQPQMIPVTQPQQQHQRPPSTTQQQVMPQVLSPNIMPDEPLILSPNADLGFNSTDFADYLNGVDHSIDSCRDLIGDHWNSFDFDNLLNSSDPSPPGDHGFPQQPLSLEHTHPQSVYSMYPSPTNISAAIPSQQQHQPVKAPQQMAFQQPQVLSSSPNRGYGNRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB76</accession>
    <name>A0A914ZB76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB76"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9908.t1">
        <property type="protein sequence ID" value="PSU_v2.g9908.t1"/>
        <property type="gene ID" value="PSU_v2.g9908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9908.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11100" checksum="D7A829828A6A0930" modified="2023-02-22" version="1">MFCWRMWLDRKMGLGEGFMEGDWDCVPSSKALLTLLIRARKDNSTATRAPPKPKTFSTHFISFFGDSIRSIVATLNYFQHKWRTNTLIQSQKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBT7</accession>
    <name>A0A914ZBT7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBT7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9389.t1">
        <property type="protein sequence ID" value="PSU_v2.g9389.t1"/>
        <property type="gene ID" value="PSU_v2.g9389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9389.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9911" checksum="1AF842ADDFA3CF1E" modified="2023-02-22" version="1">MESSDPNFNRFLHQLQAESQRQKFAEQVHTLTNRCWDVCFTDYRPPSKLDTKTQTCLSNCVNRMVDASNFMVEHLQKMDKNNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC23</accession>
    <name>A0A914ZC23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC23"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7797.t1">
        <property type="protein sequence ID" value="PSU_v2.g7797.t1"/>
        <property type="gene ID" value="PSU_v2.g7797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7797.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14617" checksum="837F735B11EAE12E" modified="2023-02-22" version="1">MIHQILGKQVDRPEAKKLWGDPFLDKKEMDEAIRTQEISEDDLLEKQLARTLIKQEKDVVEQFKRVEDVDLRQKALEEHKQAFEGQEGYYKLENQLSRGKGATTKKFDPLATPAAHGPRKILRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC73</accession>
    <name>A0A914ZC73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9920.t1">
        <property type="protein sequence ID" value="PSU_v2.g9920.t1"/>
        <property type="gene ID" value="PSU_v2.g9920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9920.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="8151" checksum="EE2B2FEBF2469F16" modified="2023-02-22" version="1">MENITPRFKEILLDEQKYTIKNKNDFVGRFSEELYNHHLEGWEDKLGYIADDNHNWHLIYAEKPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCI4</accession>
    <name>A0A914ZCI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9636.t1">
        <property type="protein sequence ID" value="PSU_v2.g9636.t1"/>
        <property type="gene ID" value="PSU_v2.g9636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037504933" evidence="1">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9636.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10874" checksum="66CB73A0ED0881BE" modified="2023-02-22" version="1">MFCLILFACLFSFINASCPNGSLEWQKSCYFFKNETIAFALAEVECVQISGHLVSIHDSFTDYLLAQKAETFFHESTMTDFWIGFTKMMPSGNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2024-05-29" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCS5</accession>
    <name>A0A914ZCS5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Malate synthase TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g974.t1">
        <property type="protein sequence ID" value="PSU_v2.g974.t1"/>
        <property type="gene ID" value="PSU_v2.g974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006253">
        <property type="entry name" value="Malate_synthG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42739">
        <property type="entry name" value="MALATE SYNTHASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42739:SF1">
        <property type="entry name" value="MALATE SYNTHASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0558">Oxidation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="6">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g974.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20644" checksum="4548E22EFEE1B703" modified="2023-02-22" version="1">MTNPAILDSEGNEIPEGILDAAFTAVIALHDIGTQDGKLKGTQLNSRTGSVYIVKPKMHGPEEVAFASDIFARAEALAGLKTNTLKMGIMDEERRMTVNLKEAIRAAKERVFFINTGFLDRTGDEMHTSMEAGPMIRKGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEB8</accession>
    <name>A0A914ZEB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZEB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8611.t1">
        <property type="protein sequence ID" value="PSU_v2.g8611.t1"/>
        <property type="gene ID" value="PSU_v2.g8611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8611.t1"/>
        </source>
    </evidence>
    <sequence length="464" mass="51870" checksum="DFE5D270773F7B46" modified="2023-02-22" version="1">MSSSESLPASSSPSSVSMDTENSEELYSFFQRQSTDKAIRRRKFSPLKHSTKDIPFYYSNSIIEEHKSVIYAVKFCQFIDGHIIFATVAGPQVTIYKCLDSKNRMEPIAVYKDPHQDEEFYAIEWAVCDIRFEPKIMLIIGGKGALIRTIDPFKGTTYCTLSGHGDVINAISTHPVVNSIIASASKDLTVRLWHCLTKTSLAILGGFAGHRDQILALDFHRSGNYIASGSMDHTIRVWNISSDSEIRERISKAAQNRPLDYLDPVEIHFSDAESRDLHTNYVDCVQFLGSYIFSKSSENFMVLSKFGEFDDPSPCGRGIRDNKPESLSQQVAKMSLPFCDMWFIKFGLTTGPPGQAWIACGNQKGAVYIWDIHARPIPEKSHYQITDNNFPQVIRKVEFSPNGEIMLVVGDGGKICRCNKKRTFGLKSSTAASQTKEQQEATPDENTQTSSSSIRDSSSAETDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEF0</accession>
    <name>A0A914ZEF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZEF0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8646.t1">
        <property type="protein sequence ID" value="PSU_v2.g8646.t1"/>
        <property type="gene ID" value="PSU_v2.g8646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="63"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8646.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21336" checksum="CF1F1137DAA7C51A" modified="2023-02-22" version="1">MYFLSLSGSPPTPQHFQSKGTFMTVRFLTDASFPAGGFTADFVSIDDSISKTHCPNGWIHDSSMNYCYKYFSTYLSWRNSSSSCKNQGAQLLAIHNSTQEFFIETIYKSQIGMQDSLVWIGLRYFKLENPSYWGWSDGTLLGYAKWLSDDNYNECGAIQVLRNQNGWKSVSCDAKLPYICYQKAVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHK2</accession>
    <name>A0A914ZHK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g978.t1">
        <property type="protein sequence ID" value="PSU_v2.g978.t1"/>
        <property type="gene ID" value="PSU_v2.g978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF2">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g978.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24123" checksum="06378D6F1D73E2B2" modified="2023-02-22" version="1">MEGVGAGGKGHRNESKQKKDHHSTEHGGGDGYDKQLAIFVKETLKIGVPKLVKDFHEARATAPKNMPKTAFEKNHDKNRYKDVICMDETRVVLSWPPENPNDYIHANWVQVRGEKRYICTQGPTSKTVEDFWRLVFQEKCKGIVMLTEVMELGKKKCEQYWPKTVGDSMTSGLCTIVNKKVTEVEKMLLSTQLEVTANGETLKCEHVLWTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHZ8</accession>
    <name>A0A914ZHZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHZ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9927.t1">
        <property type="protein sequence ID" value="PSU_v2.g9927.t1"/>
        <property type="gene ID" value="PSU_v2.g9927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9927.t1"/>
        </source>
    </evidence>
    <sequence length="432" mass="50093" checksum="870CB65A29844C07" modified="2023-02-22" version="1">MSRNQRKLNEQYRKLTKSNQPTVETPEFPNYDEIPDHEFEPMDATDFGEGCFKNVVNFNDINYERVNTETSKPIGEPLFLNSQHSVVEFSMAIMGAARQKDLTDAAVNVFLDLFRIFLPNSNKVPSSYNKIKKIVTQNHSSPSRVKEVIKCCGVCCEKLCTCGKNETTMVVIYDLDVQFLRLFSKYKVKMQNYRAEMLAEETLMDIHQTEQYKEALRKYKNMIPLSYYSDGGRYAENGKFEGWPLIASILDLPPVLRGKFTNLIFMAYWYSPVKPNWEFIFKKMNIRPFFKFDNTNYRVTCFQVIADLPAKQHFLNMLNVNGYNSCSDCDIKGENINRTMTFPYAELIQRDPKNFLIKNKTVNGVKGLSVLKEYLEKFPQGAIIDVMHSVYKGPMEDDLKRLLNGFKFNDTGTRLIKINNDGKELLEKILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZI47</accession>
    <name>A0A914ZI47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZI47"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9979.t1">
        <property type="protein sequence ID" value="PSU_v2.g9979.t1"/>
        <property type="gene ID" value="PSU_v2.g9979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9979.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="24644" checksum="90AA2797895ADAFE" modified="2023-02-22" version="1">MDQICSKTNLKDKFDEAQKLRKFVFIGITMAALITTAIADRSKRQSQSNCCGCGLSPQGPPGKPGEDGLPGPDGSQGENGNDSPDSPIPYSTPPKLQDWCFECEVSKPGPPGSPGQKGKTGMPGAKGFPASNASKGRPGPRGVIGPPGEPGLPGLRGSPGGDGQVRDYPGLEGPPGPPGVDGAPGLLGLQGLPGQQGPDGDIGDIGDPGKPGRKGKPGQPGKQGIAGEKGLSGACNCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRE5</accession>
    <name>A0A914XRE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XRE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10565.t1">
        <property type="protein sequence ID" value="PSU_v2.g10565.t1"/>
        <property type="gene ID" value="PSU_v2.g10565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10565.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15910" checksum="EF518469331E2D66" modified="2023-02-22" version="1">MFKSEFKEGQENKVVITDFPFKVVEFGIKSCYIKTEFNTMKMEENILLLQFFEKYNMEKYKAELEIYLIHKISVSNVCSLVKCSELSNSPKLEKYCTEFLLNCMKNSTPVLDIDSLDPNFALRLFKMAFFNRCDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSC5</accession>
    <name>A0A914XSC5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin-protein ligase hrd-1</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase hrd-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Suppressor/enhancer of lin-12</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914XSC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10175.t1">
        <property type="protein sequence ID" value="PSU_v2.g10175.t1"/>
        <property type="gene ID" value="PSU_v2.g10175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000088">
        <property type="entry name" value="E3 ubiquitin-protein ligase synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="22">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="360"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="599"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10175.t1"/>
        </source>
    </evidence>
    <sequence length="704" mass="79130" checksum="FAFF244A6DC0C83B" modified="2023-02-22" version="1">MENIESSITQLGQIFSQLAHLVQEQGEMITRIDSNVEATSMNVEAAHTELLRYFNNISKNRWLIIKMAARITLPLLVVTSFVCTTLTIANALVLKKQFYPAVVYITKNNVSMAVVYAQSGVLAYLAFTLIRYIFFGTLRAAEVEHATDRVWHAIMETCLAFAVFRDDFSPKFVIQFVILFFVKAFHWLAEDRVDYMERSPLITLTFHARILGISALLSAINSHFISSAYFYTMNKGASAQIVFGFEYAVLMTMVFHIIIKYLLHTHDLQQQHPWENKAVYMLYAELFINFLRCLLYFAFFIIMIKIHTFPLFAIRQFYLTIRSFQKALNDVIQSRRAVHAMNNLFPLASAEELTQGDATCIICREEMTVESGAKKLPCNHIFHPNCLRSWFQRQQTCPTCRTDILAQRRPNIVPGQNGNQQQVNNIGMVQQPQNGQQMPPLFAQILGQLQQQQRNAQGNLAQNMQQQQMPPPQLFPFMAHNFGFAPPQGPIMQMQQPQQNHSENQGTTAAPPTMPMPPLPFPGMLPMPPLNGASPYPFPQPPVFAGLSDEEISQMEGSQRSAVEARLQALSNISVLLDAAVLQFQQYLSVSNAAGVQNLVQQPPPPTSSATNASASTVTPQVSEQNIDTTLSANLPNDAPTSSTASARTSQQPNGHINSSTVSSIVEPTIQESTDDSPTDISPEEFEHQETIRRRRLQYFDGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSS6</accession>
    <name>A0A914XSS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XSS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10325.t1">
        <property type="protein sequence ID" value="PSU_v2.g10325.t1"/>
        <property type="gene ID" value="PSU_v2.g10325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF224">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10325.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="49092" checksum="AD204FAD46D37CC8" modified="2023-02-22" version="1">MNDDEEVELDVIRQPLSLFIAYSLAYSAVFILGFIGNLFVVLSITLHPSLRTATDHLIFSLALADLFIILFCLPTTLLNNLLTEWQLGAIGCKLSTFLNSTTSCASIFTLVAVTADRYLAICHTLKYDKYATYPAYVIVLIWAVSAALGIPNIIGYDEVLYDLMPPNGTLVARLCVSTRDDDFWHFLTVNVIIAFILPFLVIIVCYALIFKTVVSHRSLAVDARIRDERVKLRVAQMMLTVIVNFLLCWSPLYALYCYFFLTDPMQRDTWFFHFASSVLRPAFQWLSLLSSSLNPLIYIAYSQKYRRAFHQLLLLPCQLRMESFRQATLRSSTSGNREATNTRISNVSGNFQNNNRDNCQPKCFRWSLARADEAMISRNPFVSQPPRQTHYVQHCPGTGHKFTTNYQAYKNSRSFDISTLDDAPLTYKGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT54</accession>
    <name>A0A914XT54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10144.t1">
        <property type="protein sequence ID" value="PSU_v2.g10144.t1"/>
        <property type="gene ID" value="PSU_v2.g10144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10144.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20388" checksum="EF6C4F49F933024E" modified="2023-02-22" version="1">MDHLKLQIDAKTTYIGQSQKCLDKIQEKYLMAADRSRPFFKFLVQNSIIPLNSALEEYLKLSIEELEKILKPEDDRNEFEILRKLLSIHQIQKLIASEDAKNSEDSINLLNFAEEISKLEDCEVIGPQLKDNIAYQKLFETMEPKVVEVLTKIEKPDDEVMETQSGKDSSKIEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU73</accession>
    <name>A0A914XU73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10799.t1">
        <property type="protein sequence ID" value="PSU_v2.g10799.t1"/>
        <property type="gene ID" value="PSU_v2.g10799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10799.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18883" checksum="75C24A8A0EFA2647" modified="2023-02-22" version="1">MISSLAFLPPDQVSFGFATLSNDIRTKFGDQMNALLDYFEDNFVGRLNADGTRRNPLIPIAHWNVYMRVANDMPRTGNSYEAWHGALKSSLPSQHPGIWRFLEVMKEEFVLSINAAIVVDARNARMAKYQQISADLKRYQEEFMAGRTAIIRFLTQCSNKIKFGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUP2</accession>
    <name>A0A914XUP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUP2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10251.t1">
        <property type="protein sequence ID" value="PSU_v2.g10251.t1"/>
        <property type="gene ID" value="PSU_v2.g10251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10251.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27455" checksum="BF08C11C8DE5DC4E" modified="2023-02-22" version="1">MAGTPGRGAPNKHASEGSPRRIQRNRQQQQQQQQVKIPRSGIVPTALTAAFDHPGIAAAIRKFVFETMQKGITGLRKEFAVLRATPDQTPKVPIDSTTASKFRYKDVYCTDKSRVILTFLPNFGDFIHANWLKSELMDNTFICCQGPLLDSTGDFWRMIYQEKIYHIFMLCRCEEMGKAKCHQYWPKSPGETLIFYGLLTVRNEGVTENDSDICTTSLTLTCKIFFMYLKHFILFKFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVR8</accession>
    <name>A0A914XVR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVR8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12030.t1">
        <property type="protein sequence ID" value="PSU_v2.g12030.t1"/>
        <property type="gene ID" value="PSU_v2.g12030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002695">
        <property type="entry name" value="ABC multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000121">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF18">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY MEMBER 11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="241"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12030.t1"/>
        </source>
    </evidence>
    <sequence length="602" mass="66904" checksum="F5A643FF1658DCA0" modified="2023-02-22" version="1">MEIIEENILYGNENISHGELVAACRMANADLFISGLPNGYKTIVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQHALDKARQGRTTLIIAHRLTTIRNADKIIAMKNGQIFETGTHDSLMEKKGLYYDLVNAQVFADLNDDKPAGKILQRQTSTLSARSYASSITSAKRRRSTILSDLEDENVDETGKQSEMKRLKEDLEKEGAKESNLLQILKAARPEWVYLSIALLASIVQGTVFPAFSIFFTQIMQVFATTDMTELRKEGHTWALMFLVLGAVQACCLLLEAFIFGYSAEHLTMRLRSQLFRNVLRQDIAYFDMPNHSSGKLTTRLATDAPNVKSAIDFRLGSVFSAIVSVSCGVGIGFYFGWQMALLMLALFPVVGIGRALHFAYMKGKADENNKDSENAGRVSLEAIENIRTVQALTLEKKMFTMFSDYLEGPHQTSNRKCLIQGVTYALSSSLMYFMNAASFGFGLWLILNHHMTPIHVLRVLFAISFSGGSVGFAASYFPEYNKAKLAAGILFKMLGEKPNFDSFTEEGKKTEIKGNVAFKAIHFRYPQRPEVPILQGLNISVKPGETLALVSWPLRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW51</accession>
    <name>A0A914XW51_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XW51"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10757.t1">
        <property type="protein sequence ID" value="PSU_v2.g10757.t1"/>
        <property type="gene ID" value="PSU_v2.g10757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF33">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10757.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="17055" checksum="365F8F3BE8092FC4" modified="2023-02-22" version="1">MTVTYSLDVSSSTFCGIHKLLFRWKGSIWKSIWPELLLWLFCYAILSILYRFILPKSQQIQFEDLCVFFYTYGDYIPLTFLLGFYVNAVFGRWSEIFNNLGWIDSPALLISTYVKGDDETARKIRRNIIRYMVLTQAMVKLFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWM3</accession>
    <name>A0A914XWM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11622.t1">
        <property type="protein sequence ID" value="PSU_v2.g11622.t1"/>
        <property type="gene ID" value="PSU_v2.g11622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11622.t1"/>
        </source>
    </evidence>
    <sequence length="395" mass="43406" checksum="A0E35815814FEED6" modified="2023-02-22" version="1">MKKKIHQKGRPKNTTSNDDEEDILKEDVPVPKQRKKLGGTKAAPVVAEEEDEEALKEDDEEAPKPSKKGRPKNVTVKEDEEALKENEEVESPKSDDEKEAPKPEKKGRPKRAAASAKKGASKEDEEAVEDEDEAPKPLKKARQNKATPVVAEDEKEEALKENDDEEEAPKPAKTIRAKKANAKETEEVLKKNVPAVKSTKKGAKKATPVAEDEEVLKENDEDESPKPEKNIRPKRAAASVKKGALKEAVEDEEEAPKPLKKGRTKKAAPVVVEEDEEVLKENDGDESPKSDDKEEEAPKPEKKTRPKRAAPPPKKGASKEAEEAVEDEEEAPKPLKKGRAKKAAPVVAEEDDEEENSPVEKEAPKPAKKGRPKNTAAKEDDDNATKPSGRGKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX10</accession>
    <name>A0A914XX10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BUB1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX10"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12484.t1">
        <property type="protein sequence ID" value="PSU_v2.g12484.t1"/>
        <property type="gene ID" value="PSU_v2.g12484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF28">
        <property type="entry name" value="BUB1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="1">
        <location>
            <begin position="57"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12484.t1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44305" checksum="362F915D3F0A48F8" modified="2023-02-22" version="1">MSTESTTTSIPSEPTRQLDWFDNIENIRPTRSGHSAAAVLAAATAPVVTINEAREKFTNAMKEAETAVDPLTTMVQFVKWFDDHFLSGKTSVLHPMLYQILTKYGTERRYRNDERIMKLWLRLADNFPERGFAVMQLACSRGSCKELAKFYIFWSRMYEYAEQMDRAREILRRGIFNRATPITELNEATDALEVRILRWTMEKEKRQAELDLSDDDYSNMEDTRRMFGQIEVEETERGYRAPTVRTDTSTPKKLNIRAPIKADFDVYVEEEEEESSSQNSNWSIPKVEEELSSDPDWQSIFGYQDTPGIHLDITENTVTHKGGIIKVKPSPEQPLAAFSVYCETQKTKLKFAVRRELVYNCSIEEAYVQQLLQNDGKDDCQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXM4</accession>
    <name>A0A914XXM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ homolog subfamily C member 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXM4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1196.t1">
        <property type="protein sequence ID" value="PSU_v2.g1196.t1"/>
        <property type="gene ID" value="PSU_v2.g1196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="543"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1196.t1"/>
        </source>
    </evidence>
    <sequence length="595" mass="68629" checksum="A1B8665FF75F9991" modified="2023-02-22" version="1">MQVAIYGFQNRIKRIEDAGIAYELNLILDRLALGLSPEPVLKNYRRAGKDSPTLEELEAEEDEALFDEDCDGYRKFLSKLCPKTWREQDHYKVLGLSKLRYRATPGQIKTAYRQKVLRYHPDKGKYKEQLGVQGNDAFSCIQKAYELMCEEDKRRSYDSIDPDFEEETPTASEINTKNFFTKLGPVFEANARFSKVQPAPLLGDINASRSDVEHFYEFWYSFPSWREFSYLDAEDKSKGEDRYERREIEKQNKIEREKLRKQDSKRISNLIHLAYDKDPRIVIFKKEDKQKKEDEKERKRLEKQKREDERRAVELEEERKKAEEEEKVKEEKKKADKARQAEKKVTAAKRKKLREVAANAEYWTKHSGSKLVVMEHIERICIAGNNDQLDEMTEKLAGLTVYDEVVELLTNRTKKDATQKVAKKETSEVIGGKESGWTDEQISLLVKAANIFPAGTSRRWAQVTSYINDHHRDGVPKTEKEVIKQAKLQAAQVVAPVDASKTQGQKETTFNSNGAPVTSSNSTTNATVAPASSNGTSIPLDDWNTDEQMNFENALKTIPASDPKRWEKIGEATGKTKKECIQRYKKIVEMLKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYY3</accession>
    <name>A0A914XYY3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914XYY3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11746.t1">
        <property type="protein sequence ID" value="PSU_v2.g11746.t1"/>
        <property type="gene ID" value="PSU_v2.g11746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="339"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11746.t1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55439" checksum="496AABA9008A2599" modified="2023-02-22" version="1">MASTNDGMSPDYDEACTSASDFDELDIKQAAQFGDISKVRHLIESGLASVNDTDSDDCSLLHWAAINNRHDVVKYLIDNKCDINHVGGVLRCTPLHWACRQGLTRMVALLVKNGANYDICDGEGFTVLHTACQYGRTPIACYLVAKGQSPDIRDASQMTPMMYSAARSVGRDPLHMLVSMGADINATDGIFGHTPLHFAVIHGNHSGISNLLKLGANPSILNKENETPLDIAQRKNDYLSMRLLESGERQAGLRRFTWKQRLYEDQNIRSQIAFILPFLFYFIPGFIFNSKIDIIVKTLFVTAAYGICAFLINRDPGILVYSHAEQCRQIIEMTEGDNFEGNFCSTCLLIRPVRSKHCRYCDKCVRRFDHHCIWINKCIGSENHRLFISYLILLQVSAFVVITGCILYINDFCGGISFHNLACQPWVSYTLIMSINLFFWLSLLSFMQFYGIAQGLTANERINAHRYKHLNSGTFARNIFSIKTFNVWINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZV4</accession>
    <name>A0A914XZV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12736.t1">
        <property type="protein sequence ID" value="PSU_v2.g12736.t1"/>
        <property type="gene ID" value="PSU_v2.g12736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12736.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18568" checksum="36BC8213DE7732AF" modified="2023-02-22" version="1">MTEPLTKPGEKLQIVPEFLKTFILTISKTFYGLEHFVIADYIQRNVCVNEERLRQFLKFDPKTLKPILVALKVDKIIKERIVTEEIQGRQRKIPYYFINYKGAVNVTKYKLDQIRHRLEAQEQTKSNRTLFHCSNCGRQYDQLDVGKLFQPETGKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y127</accession>
    <name>A0A914Y127_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y127"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13912.t1">
        <property type="protein sequence ID" value="PSU_v2.g13912.t1"/>
        <property type="gene ID" value="PSU_v2.g13912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13912.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8147" checksum="BF3F5DB7421FEC20" modified="2023-02-22" version="1">MEIFGDDLGFMNTADVAPLRNFKIYKMFPAKMEANKRSFKPVQYAFNNHIEDYLPMPIKTLTPLYDHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y199</accession>
    <name>A0A914Y199_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y199"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12563.t1">
        <property type="protein sequence ID" value="PSU_v2.g12563.t1"/>
        <property type="gene ID" value="PSU_v2.g12563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12563.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25773" checksum="E615285BCF40B045" modified="2023-02-22" version="1">MIARLRRRFESKSRDSVGSPPTSPGFGKSLNFQCVICFESYPSQEGFIVCKPFEAAVTSPRDPHKLCIDCIRGHCHAAIDDMALAPGGIGLRCPDPNCKNVLHFADFKFYLGPEDHERLEKRMQHESVTSASLSDLVTCSSCSLQSCVDDVYYYFTCQCGRIQCRNCPRTFDEKHEGKTCEELDEEEKDSNKLESKLSEIVVRICHRCNVQYVKQDGCNKMTTVTFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y257</accession>
    <name>A0A914Y257_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA damage-regulated autophagy modulator protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y257"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11889.t1">
        <property type="protein sequence ID" value="PSU_v2.g11889.t1"/>
        <property type="gene ID" value="PSU_v2.g11889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11889.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36769" checksum="CDBE401D6FB0B934" modified="2023-02-22" version="1">MPLHALWLFPVLTTVFGILAFVIGYAIAVSNGYENAWFSYISDGGTHPPESCIFGQLLNLSAACLAVSVYLRHRQYVVFYEHHLGQKRGWWRTVSSVLMFIGYFAAFGMSMVANFQETSVGTVHFIGAMIGFFGSTIYIWGQIFLSFTMLPRMTPIWLNTFRVIITIIATGALILHMICEQAQPFVKKDANGVKPTEPPLKDGIKRYSPGNPYYVNHIYATVAEWVLALALEIVLLSYAFELRQFFAHMPKLQLVESFLATSVRSVITETPQSLKRNGISMVMARTLTGSAKISDSSSSHIPRAKVDEKVFETQTRSPLRRNEYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2M0</accession>
    <name>A0A914Y2M0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2M0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14426.t1">
        <property type="protein sequence ID" value="PSU_v2.g14426.t1"/>
        <property type="gene ID" value="PSU_v2.g14426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF19">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14426.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17433" checksum="05A11585915B381D" modified="2023-02-22" version="1">MAFFFVCKLYHKIVNKANNVAFRFNQNPKMPFHKMENISNFLNAIKLYGVPEISCFQTVDLYENKQFYKIIECLRALAAVAQSKSAPIPFPNWVVKISQKQKREFTNEQIKGGEAVIPLQYGTNKCASQKGMTPYGLSRQIKQSDALLNNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2N2</accession>
    <name>A0A914Y2N2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2N2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13499.t1">
        <property type="protein sequence ID" value="PSU_v2.g13499.t1"/>
        <property type="gene ID" value="PSU_v2.g13499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13499.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13376" checksum="D5133A9E7C84B215" modified="2023-02-22" version="1">MHDSMDVFTFVKFAQHLNIKLSGELYHILVSGEYEKRFSYTFPVFKHQKHKDQKIQELFETLDGLKYYNCNLKPTKGDRDAQYWKWCKDKMFYVSAIAQGKIACRYDSQTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2V1</accession>
    <name>A0A914Y2V1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2V1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13774.t1">
        <property type="protein sequence ID" value="PSU_v2.g13774.t1"/>
        <property type="gene ID" value="PSU_v2.g13774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051765">
        <property type="entry name" value="PH_domain-containing_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280:SF3">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13774.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13565" checksum="32A42476673A283F" modified="2023-02-22" version="1">MENGLKVSMQLFGFQTMKPLYHHCRSCGHVICGNCSTKRFVLPGINKRPVRVCDECYAQLVKGNITVVVTNANTVNNIPRIDSDDSEDEDETTDRHVNFAENNQAQFYGSEEAQGPISTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y330</accession>
    <name>A0A914Y330_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y330"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12178.t1">
        <property type="protein sequence ID" value="PSU_v2.g12178.t1"/>
        <property type="gene ID" value="PSU_v2.g12178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12178.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12453" checksum="84560E24C7916114" modified="2023-02-22" version="1">MKPGNSGMSLISSTRQYSIGMGKDQQPNSRLWIETINDPKIVHLYCLNSSNDEKDVFICGHCKQFNRITHIEILHPEGGKTELWEETTHFPSCIRQKIDVEKYLLGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3D0</accession>
    <name>A0A914Y3D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3D0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13279.t1">
        <property type="protein sequence ID" value="PSU_v2.g13279.t1"/>
        <property type="gene ID" value="PSU_v2.g13279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF12">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13279.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27354" checksum="833766F361CB9042" modified="2023-02-22" version="1">MSMAKRICFNVGGRVFETTEQTIRRIPDTRLTSLLDGAPNSDEFFIDHDPRYFEVVLNFLRSRSFPADYAENIIDDVEREAKFYGISELANCCRTLREPLKMHDEVQWRKDAIEHYWRNFVQCVVDNSLKMPFTFEKNSHFFAKCIACAEEYDPKTSNVYDVHVDDWSALSHHMLSLKGKIIQIFGQTCVMVKFENNTTVHVPRTAIKRVGNLLDLSDKTTNTSARKAPLTSTASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3N4</accession>
    <name>A0A914Y3N4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3N4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13384.t1">
        <property type="protein sequence ID" value="PSU_v2.g13384.t1"/>
        <property type="gene ID" value="PSU_v2.g13384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13384.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45311" checksum="C442604027C657D1" modified="2023-02-22" version="1">MLCKLIDEISARVRKVQVHVNELGTNPLILQDLIEEWAMLTWNVLCISSRLQNNYQSVLTSSEDKQIYSKLNSSLVELVNCTSQIVFPDSLIFDLPHLQFKTLSLALGNTMQQQYNLYKFLKMKRDSLPWQPSETEEFAQQLHEFSEQSLIPFIELFKTYCNEFSVALWRDVRAAQIKKMIDLQPIPDAPVTRLVSFYSHMVYALAILGARLQGFRYELTQNKIFGSYGNYDPIKPLSDTVFSALELLMADCVLCTEPSIDPILVTNNLFPINCGALARGVVFKQFDVQLVTEEVAEHIQSEMRRQKLLQQPSPIQNAPSAALLAMKPATGTKRANNSSTQSDSSGNTSHKKSDVNSKDIVTIYPVYHAKNRYWAATYPHLLCTTRQKGRTSTHSSFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Q5</accession>
    <name>A0A914Y3Q5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Q5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14827.t1">
        <property type="protein sequence ID" value="PSU_v2.g14827.t1"/>
        <property type="gene ID" value="PSU_v2.g14827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="8">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="10">
        <location>
            <begin position="660"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="767"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14827.t1"/>
        </source>
    </evidence>
    <sequence length="963" mass="106909" checksum="CB5E5CD97671D6D2" modified="2023-02-22" version="1">MRDQERQHSQKNRFAQMSEAQLAEYFQTRHEVDSAPINGVNEEYYDAITQNGLLPDARSPNLYIVKCRMGEEQMLCVQLMKKYLAFLRTDEPLEIKSVVVKDGIKGMVYIEAYKTPHVLKAIDGIHSFNAYNIKMVPKTEMVDTLKIVKDIPILKAGSYVRVKRTMFKDDLAQVDDIDLTRNEVILKLVPRIDYTKLRGALRGQEGDRGLTRRKGRAPLALFNPDKIRNIGGEFTKDGDFYIFENNRYRNGFLYKYFNIEHVEVDGVKPTISELELFNEGSNEFQGELSVGKDFAKYHSFAPGDTVEVTEGELVNLQGRIQSIENDLAYIKPENSELKDIVTVNIHGHYKGDTGMIVRVEENLVILISDINNEEIKVLPRDLKLSPHVATGVDSHGRFQLHDLVQIDKDAFGVITAVHTDKLTLLTNRGAVSHLKSSQILRKIDSKRSCGLDANKQSIVNGSQIKMLDENNKEAEVLHIYRGACFLNCRTHRENGGILVKPARQVAVLGSRVNGAAPAEPLFKVPQSPRHFLQSPARNSSAESSIGARSDGSRTPFNGESRGNNRNEGGRGGGRMNGFGGGANQPRRNMTMIGKNVRIKGGPYKGHYGIVKDATESTANVELHANCKTQQFDVNRLEVVEGEAGVGANYRNLARTPSASTARTPAYSGYQTPMYGSQTPMHEGFGNRTPHYGGQTPGYDGSRTPSHSSAWDPSALATPAHSSFGAHDDDNDNDDINYMVPTPAVAQLVDESGDDFYDTAPMSVNPFTPAGFSNYEPATPRNDHRQIDSPPPPARNSFGQQRESSPPPRNHFSQQRSPPRNDFSQRRASPPPPARQQPSRTFTEIPDTLIDTGDWCDIDMLINVRRNCTQGSLHGKTLPITRIEKGKRQVIVKNGNEKVSVDFKDILPAPPVEEGSIAQIIFDATAGKLFTNAPPPEPVERIEGNTVVFENGDRALRSHCVAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Z8</accession>
    <name>A0A914Y3Z8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Z8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1416.t1">
        <property type="protein sequence ID" value="PSU_v2.g1416.t1"/>
        <property type="gene ID" value="PSU_v2.g1416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF143">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1416.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42294" checksum="54A9680E484E3739" modified="2023-02-22" version="1">MISNGRIADTLAQAGHDVTFLSVEGIIPTADFPTTKLSKQFNGTAFVENQETIEKLKAEKFDAIFYEQLFPHGASLGHLLEIEVHFLINSCPIQGHITSLFGIPDPTGWVPAVGNLEISDKMTFFERIQNEIEHFSLTFGYSLLFSSANKVFQNIYGPKFPDVQEIMKEKVPMMFVAVDELIDFPRPIFHNIIYIGGLGMKTSIKSNETLKAPFDSEMIKGKKGIVYFSLGSNCDTTFLPKSVKTNLIDAFATFSDYHFIIKLEASDNYGIKYAKTKSNIFVTNWAPQTLLLQHPRLKLFFTLGGYNSLLEVANAGIPVLVMPMMYDQTRNGQVVERNGWGKVLNKMKLLEGKENLVKLLNEMLNNEKFVLLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Z9</accession>
    <name>A0A914Y3Z9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Z9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13955.t1">
        <property type="protein sequence ID" value="PSU_v2.g13955.t1"/>
        <property type="gene ID" value="PSU_v2.g13955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036926550" evidence="1">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13955.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11933" checksum="B1740C015E798FA8" modified="2023-02-22" version="1">MNSKILLVLCFIGFIALISAIEESKSPVKYIHMEHSALPDFESSDVPHERVRRQWGYGMGYPMMGMYRPYGMGYGMGMYRPYGMMGMYRRPYGMYRPYGMWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y441</accession>
    <name>A0A914Y441_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y441"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12513.t1">
        <property type="protein sequence ID" value="PSU_v2.g12513.t1"/>
        <property type="gene ID" value="PSU_v2.g12513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF575">
        <property type="entry name" value="LOCOMOTION-RELATED PROTEIN HIKARU GENKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="136"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="194"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="252"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="429"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="531"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12513.t1"/>
        </source>
    </evidence>
    <sequence length="718" mass="80017" checksum="39AC0C3567B3766B" modified="2023-02-22" version="1">MWTVMSATCHPLVDLPNGFLRTPSDFIFDSNVEYGCNEGFILIGPSQRRCQGNREWSGSKPVCRPQLKCGPPPELPYAHHNGNSYDGQYDIESEVHYSCVSGYERFSNNELPIAKCLLNRKQIAQWFGPDLRCAARSCPDPGTPLNGYRKGELFQYPHSIEFSCAIGFRLEGSRIRKCTTKGEWTGDPTICRPTECSRPSDPLHGNVLGSSLTYQSVVTYSCNEGYRLVGQVQRICLAEGSWAGHEPRCEEIRCPSLPLLYNGYIEGEDTNFGSMVVFRCLESMSHIGAPYAKCEEDGQWSHVMPKCLAGCRIPQIHNGRINNFHTNELIPHGASVNVICNAKHETKSAETVSCHNGTWSHVPQCVPIRCRAWPERVSNARVIFTKSMHGAVAKYICRHGYHPNTDNNVIKCLFGKWTREGPPFRCLAMSCDHPTKKYGILEGGQIMLEGQMGAYDFADYISRVPEGRAIVFECHKGNRLIGPPKATCVNGAWMPDIKPKCVSQRHPAMDGAIIWNRSKRVALGGGLAAARSCPETKSDETKNIIFTKPHRELIIICRNGFELTNGDGVSHCRNGIWYPTIAECQPKKCKIPSRLHAFFLQTSTAKIYQSGDEIKHSEGVRLVCLRGFHIVGENILECFQGTMLQKAGECKARSCKLPSVHAGKFLHKKSKLKHGAFATLKCEGYQEMIKCNFGQLSPPPTCDKNCKSFIGNKGKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4C1</accession>
    <name>A0A914Y4C1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4C1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13621.t1">
        <property type="protein sequence ID" value="PSU_v2.g13621.t1"/>
        <property type="gene ID" value="PSU_v2.g13621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000005">
        <property type="entry name" value="Quinone-dependent D-lactate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13621.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15109" checksum="09AA2B40443EA8AC" modified="2023-02-22" version="1">MSSMTTTDNKAFLNELARLVGSSHLLTDPAKTARYRKGFRSGQGDALAVVFPGSLLELWRVLKACVTADKIILMQAANTGLTEGSTPNGNDYDRDVVIISTLRLDKLHVWQGRTGAGLSGHHALFAGKPSNRWDANRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4F4</accession>
    <name>A0A914Y4F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4F4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13650.t1">
        <property type="protein sequence ID" value="PSU_v2.g13650.t1"/>
        <property type="gene ID" value="PSU_v2.g13650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13650.t1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43735" checksum="1864F7312F8C3938" modified="2023-02-22" version="1">MSRRPRNASHDNASTTSSLGSYSRSRSPGSRTSSTRRIPPPLERAQSIKDKTAHFFGIPSGEGNDSANLSSNAKWQRKRLRHLQKEYGLKPEAIQSVAAAVTPVVEYDVLGDIVNNLPPPDTTPSSSLPRSDSDGSRIYSRILSMEAPQMERKESVMRMAVEACESIVRGEPFRRSRKFPANRSPGNSFSIRRNQSTLTANSSFPIRPPIIMQALPEVSTDAETSFSEPSRDPDRPFVGTPIQSDEEIRDFDNRPRFGIRPEGRQQAFIFPGRRQQVTATRGRSRSSPLVHQLKVEESEDELPPKPREESRVKFADVKTREMDDERSDNEQQSTSGTTTTSALRPKELLIPFLNKSQQQESRRGVQFVEPPAMSSRGRSKMDTGENVSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5R2</accession>
    <name>A0A914Y5R2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5R2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14778.t1">
        <property type="protein sequence ID" value="PSU_v2.g14778.t1"/>
        <property type="gene ID" value="PSU_v2.g14778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF12">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14778.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19241" checksum="419FD67BB73451C7" modified="2023-02-22" version="1">MFSMKIGEGTNRYVQFDGMIHYYKRGWMSNKWNIVYAKLWSDSTLEWFSSKGSDKPLGTVYLGNLVPFICIGPQIRKVPSKKPKVESTWDKNFLMAVASDQKAATVHWFYFDNGNNLRKWIAEITKTLPRLAHPSSYRRREYGNDNFDNNQRNYVAISPNDPNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y655</accession>
    <name>A0A914Y655_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y655"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15675.t1">
        <property type="protein sequence ID" value="PSU_v2.g15675.t1"/>
        <property type="gene ID" value="PSU_v2.g15675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF7">
        <property type="entry name" value="GLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15675.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17293" checksum="CC68715C8574132B" modified="2023-02-22" version="1">MPKVKDQFRRCPLPRSFPNHDSFAKAHSKAMADLVDHVVENLDNLEAISPELERVGRVHAQIMRGELSSKLWNTVAETFIDCTLEWGDKRCRSETVRKAWALIIAFMVERIKTGHLEQRKHMLTMRTTIAALERTELKNAAAAVAAAATAAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6P8</accession>
    <name>A0A914Y6P8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6P8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13318.t1">
        <property type="protein sequence ID" value="PSU_v2.g13318.t1"/>
        <property type="gene ID" value="PSU_v2.g13318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13318.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13137" checksum="149931FD989E9B02" modified="2023-02-22" version="1">MAPPPNIGGGGDNNAAAIPGQNQQHQFIPPQNNAGDNNIEMVDIGDGLNNDDGDEMEEDIPLHNGDPIAAVLGFENHQQLNIINHDDEDDAGQGQNLEDDDDVEHQQQEQQLPPQNAEQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6W1</accession>
    <name>A0A914Y6W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6W1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15948.t1">
        <property type="protein sequence ID" value="PSU_v2.g15948.t1"/>
        <property type="gene ID" value="PSU_v2.g15948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15948.t1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50715" checksum="3A9962878AF26CA7" modified="2023-02-22" version="1">MSIYTKTSSSDHLSGPVVISYRINLEESVIIDPIVTRPTPKLWIDAFIPKKKSDIIHGPPMDIFIEWLKCWKKRLILLAKLENEPPKKKRKSRKHEEDSDYEPEKETDELCSTFVLSGPTGCGKTSFVHFLAKEYGFDVIELSASDERSGATMRNKLQGALENFAVRGPGDIRSSMIGAKKSKESGVKHNLILIDDADIVFKSDTSFWTKLGAFSVESKIPIVLTCTDRHFVICNMENSEFEGENFLKREKKVISRHLKQWISDYADVTIDANLIATTINESKQDIRKALNNLEFNGGKLFITENPTFPKFSLSSKRVDNNNEYFINDITNLLSSSLPASFEELNKKDERLSTNLQSCRGIYAPILTAVYDTFKRCEPGASIRNVALYELPILSAIHRGWSERIKNQPSRRRVLHPFNDVRKDNEKALDRLGKLHTTIDQYCTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7C8</accession>
    <name>A0A914Y7C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7C8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15178.t1">
        <property type="protein sequence ID" value="PSU_v2.g15178.t1"/>
        <property type="gene ID" value="PSU_v2.g15178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15178.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10647" checksum="AB68F32FEA846260" modified="2023-02-22" version="1">MGTLCPQNVSFGCEGDDSANQPNIPMFGYDAVMNTWDTSHSETIAKPLIHRCFNSILTLECPAKALISFDFQGEIMVLDLLKVVAEDQKEITVSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9K8</accession>
    <name>A0A914Y9K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9K8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15966.t1">
        <property type="protein sequence ID" value="PSU_v2.g15966.t1"/>
        <property type="gene ID" value="PSU_v2.g15966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15966.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22668" checksum="4BE5E570E36AD2C9" modified="2023-02-22" version="1">MPKRKHEDAAGDLDDTLPSEAVSKKKKWAPEVANELEENGAPAKIEYWIVRKPKNIKTNDLPIFRFPKRLPAKDKAVLRTDRENEYINVKFSEVSKQMFYINRENAITLSSGKKRVHPTAEIKGMMFMQPEDADTYVGPIPPEEDFLNPENCTEPADLPYEIPAIRRRPTTGKYEPLERVKAFGSGLRKKRSKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9T8</accession>
    <name>A0A914Y9T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maturase K</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9T8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16978.t1">
        <property type="protein sequence ID" value="PSU_v2.g16978.t1"/>
        <property type="gene ID" value="PSU_v2.g16978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16978.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="12061" checksum="93D2CF4156979C0C" modified="2023-02-22" version="1">MEKCNLRSLDIWNQSLTYDEYSFLTSSGDLKRLYLNEYIICHPNGTLVTFDQLFKNIPKLIAFFMVFAENYSSMFESDTFKKLTDILPHLKELDLYGLTERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA91</accession>
    <name>A0A914YA91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA91"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16346.t1">
        <property type="protein sequence ID" value="PSU_v2.g16346.t1"/>
        <property type="gene ID" value="PSU_v2.g16346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16346.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7650" checksum="ADB846712EDFB4A4" modified="2023-02-22" version="1">MGCSQCRHNSVKESFSAEEILIKVLRIIQSERTTMVFRNIIALELVYDRQPIDNDRDPVVESADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAI8</accession>
    <name>A0A914YAI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMP-LTD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAI8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17220.t1">
        <property type="protein sequence ID" value="PSU_v2.g17220.t1"/>
        <property type="gene ID" value="PSU_v2.g17220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17220.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11283" checksum="059C33E50DB5F092" modified="2023-02-22" version="1">MEEVSSTRLILNVEVTSLEGTLALNLPPPPSDRLWYAFRNPPTMSVKAVPQVGDRSVAFSTVSEWIVSKIKLVLEKNLVVPNMDDIRISVLGGNALLNAPLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB41</accession>
    <name>A0A914YB41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-type LECtin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB41"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16632.t1">
        <property type="protein sequence ID" value="PSU_v2.g16632.t1"/>
        <property type="gene ID" value="PSU_v2.g16632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024:SF13">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111504" evidence="2">
        <location>
            <begin position="25"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="94"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="298"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16632.t1"/>
        </source>
    </evidence>
    <sequence length="436" mass="47460" checksum="206B71EB67260C72" modified="2023-02-22" version="1">MAVFKNVLIFVIFLAVALNKKVASQSDSTDFTPVYSTNAPDATTPPPPPPATSGRPQTTAPTRRTTAPPPSPTSGSPLGLDRECACTVEKIWLDIVAVIDISKSITQEGLAQVQANLDTIVHRINVGSQAGYNSRISLVSFASNATTVASFSAFNSSDDFDNTIFNINVNTADDKVNILSGLQTANSILGSSSVNPNRRRVVILYTSAYDNGGFKSPIPLAQQMREDNVKLITVAFAQSMGSSDVDAVSELAYPGFAFTNNQTDLIDQMYTALCQANCFCPPNWRQFTANYTNKYAYGYGNCLYYSSISAGWTAASFACRKEAPGAYLASESTQKKTDFNLAYSKDISVNNQYSYHIGLEYKNNQYSWQTSNSSVLSALGNSFKNWNPGYPNSNVGECVKVDKVFGQSYGWTNEKCWSALNYICEVTTCDTDNYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBB1</accession>
    <name>A0A914YBB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sec16 central conserved domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBB1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14769.t1">
        <property type="protein sequence ID" value="PSU_v2.g14769.t1"/>
        <property type="gene ID" value="PSU_v2.g14769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 central conserved" evidence="3">
        <location>
            <begin position="383"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14769.t1"/>
        </source>
    </evidence>
    <sequence length="634" mass="73060" checksum="AF9106F1BF1C8790" modified="2023-02-22" version="1">MDRHRFPPGNGGRPHSMQPLQQQQQQQISSLSRRTLGLRTPGTALLSQPKAIPALLKSTKADFGEDYIDSQRRNRFGRNGGARARSEIAEVLSNGGNSRMNASYYQHRRETSYNDDDRHSLKAVRSTSYYDRPRSSFEPAMNQSSAAVPRLIVRNRQDDWQEVERRHQNQYSTDEDFDDEEMDSAESDQLREELEMYNSRRGNPSQGYGGARTSSSYYAPSSRQPPLRQEFSENDICFFGMLKLTPQKARQFMTMKEPPPEFWNLTSVEKAAYLYYFSLYKQYIVPVVKFHKIFNREFFKYTADGDSDDVALMKICKHTYDEYDLRRQRINKQAYDRSRHHLFSDDRATPDSRATSYCDPLDESDITSVDSGAKEPHRFTKPHAFASFAVGGKLLILNPEYSISTVQLIDVKRKIRDRGNMRNIDAMEHFKGPLIIGETPSHTPLLFIERQINNIRNSEIYRQNPLSSDANDVLLIWRLLEMLIRQHGNVTGPDLARLLTENYSFSSPQKGVRGRADKEYLQATNGVEGHETGSPMFAAKDERRVDQRAMDRFTQFLLGGYIDEAIESATSDGLFFDALILAHRMFGNDRRKMEQIESKLLSYRDPQHPSLTLLSVASQMPVPILVSIFLYFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC24</accession>
    <name>A0A914YC24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1631.t1">
        <property type="protein sequence ID" value="PSU_v2.g1631.t1"/>
        <property type="gene ID" value="PSU_v2.g1631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1631.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19802" checksum="8E2F11F178B92EE0" modified="2023-02-22" version="1">MENQQQATALCRGGCGFFGSSATEGLCSKCFKDSIKRKQDTARISPNNSNSSNDAMAKIREAVKNVPDLAAQLEDVAQSLCSSVNPASSSKVVPEVLEPAVISSSPTEEIAVASSAPGKKANRCQMCKKRVGLTGFTCRCGGLYCGEHRYDAAHDCDFDYKTMEREEIRKNNPVIVSDKIQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCC8</accession>
    <name>A0A914YCC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16952.t1">
        <property type="protein sequence ID" value="PSU_v2.g16952.t1"/>
        <property type="gene ID" value="PSU_v2.g16952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222:SF76">
        <property type="entry name" value="MYCOBACTIN IMPORT ATP-BINDING_PERMEASE PROTEIN IRTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16952.t1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40554" checksum="3BBAD188766ED906" modified="2023-02-22" version="1">MTRVHPTSESAVDVSYQAKKVDVNSLQEVAFSPPVYDDEDEDAPKILYEPSLAEKIINLLLCRTDLATQKLEHRPVSLKGLFRYAKPFDIFLMLIGLACAIAAGIAQPVLALISGRITNVLITYPPGTPQFRPKAYENVYIFTGLGIVCSLVNFFQYFCFQTVCNRIIAKLRYKYVASIIRQNAGWFDKNHSGTLTTTLNDNVERIREGIGEKLGLLLRGAAMYIAALIISFIYEWRLSLLMLGVAPVTCVVMSFLSQKMGSTTIKELGGLGKAGAIAEESVLGVRTVQAFNGQPEMVDRYRAELDKGKKFGIEKGYWAGFLGGLFFFFLFSFLGAGILYGAYLLKVGIFTNPGDVFICVICCSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCL6</accession>
    <name>A0A914YCL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17039.t1">
        <property type="protein sequence ID" value="PSU_v2.g17039.t1"/>
        <property type="gene ID" value="PSU_v2.g17039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051286">
        <property type="entry name" value="JAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807:SF7">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17039.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23511" checksum="7BB51390D46D9B14" modified="2023-02-22" version="1">MDITKHSKERFSYIKKGSNNAYTLPPINVGNDKIQIPENTFLLNFPTKDLNEGRLLLEYKEGIGCGRFGTVYKCPYIDDGKLIWVAIKEPAKEIEALLKLNHLNIVELKAVNQKENLILVMPLRKSDLKTFLRHEKSKITEYHQKRYCMQIADACRYMINMEIVHCDLKASNILVVNINHIEITDFGKSERLRQNKGKHVLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCV7</accession>
    <name>A0A914YCV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ENT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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</entry>
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</entry>
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</entry>
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</entry>
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    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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            </authorList>
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        <location>
            <begin position="9"/>
            <end position="70"/>
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    </feature>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17927.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="12170" checksum="39804829C90D1B6B" modified="2023-02-22" version="1">MAYNATGGIQRKKSTKEAQIERTVLRELEERKRTWDINRGQFEKFQQWYIEYRKNIWHKDEYLPWLLYENEISCLRLTFDVCERVPRRKPYGGKGYTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF57</accession>
    <name>A0A914YF57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YF57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17392.t1">
        <property type="protein sequence ID" value="PSU_v2.g17392.t1"/>
        <property type="gene ID" value="PSU_v2.g17392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17392.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11015" checksum="67AB1B96D0BE9177" modified="2023-02-22" version="1">MSELDQLRQEAEQLKAQIREARKAANDTTLASVAANLEPIGRIQMRTRRTLRGHLAKIYAMHWASDSRNLVSASQDGKLIVWDSYTTNKFFYFEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFE5</accession>
    <name>A0A914YFE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19020.t1">
        <property type="protein sequence ID" value="PSU_v2.g19020.t1"/>
        <property type="gene ID" value="PSU_v2.g19020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43351">
        <property type="entry name" value="L(+)-TARTRATE DEHYDRATASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43351:SF2">
        <property type="entry name" value="L(+)-TARTRATE DEHYDRATASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic" evidence="7">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19020.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10110" checksum="1E9B96BAEBC39578" modified="2023-02-22" version="1">MDVRWDDATMGVEDMANEGVRRAYMHPDNKLRASVLADPAGKRINTKDNTPGVVNVKVVPGNTVDVIVAAKVWSKPRPSSRCSTRPTRSSTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGR2</accession>
    <name>A0A914YGR2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="5">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGR2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16514.t1">
        <property type="protein sequence ID" value="PSU_v2.g16514.t1"/>
        <property type="gene ID" value="PSU_v2.g16514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16514.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="30215" checksum="DA861C64E2949FE9" modified="2023-02-22" version="1">MSLRKLAKINQRTHRERPQPESRGTFGYLEHKKDWLQRANDVSIRKKKLKHLRSKVLEKNPDEYRHHMVRSGISIDGIHRELDPDSDDETVLQKKFEGVKDLHYVKHKLSVERKKIDKLKSTLHLTDAQVTPNQHIVFVDDEEEAKNFDPAEYFNTDPEFLGRRFNRLTKEAVSKNAVIAQDKEQVKEIEKIRRTQYKELQLRIEREKELAVVLQKLELKQALENSKGNELKPKMIKKGTANRAAVYKWTYDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH90</accession>
    <name>A0A914YH90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19686.t1">
        <property type="protein sequence ID" value="PSU_v2.g19686.t1"/>
        <property type="gene ID" value="PSU_v2.g19686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19686.t1"/>
        </source>
    </evidence>
    <sequence length="466" mass="55244" checksum="0B54CC1BE0FB3451" modified="2023-02-22" version="1">MDFTGPIYINMREIVKDIDVIVKELISVASRPEKSEDDHNLLQTLPRLFAKKEREYEKLCKIYQHRFKVKKYIEELEKVTSVQDRKMQLLSESFGKIYNNLSELKRRVEVQTGLNDSEVFLNNDDIIKAAGLYSRSHSVCAPDKNLNKFRPYPTIIELKKGRLAQMTAKNIAFKQQQEQQHQQPDIPYILSMNGQDLKEKLQIYPTLLNSSASNSSYMERLKQNSEKKPKSNKIWTHYREPVESVKVTEWNDKALNPQGYIETYTDSNNKTDGKPDNDDNEPRRPQTPEYPLVNLVPMQEKHSIFYKALISGDEEDLFPNEERLNQPSVQSCNMVDGDNSEIYERFQEIAEYSKQKYYNSFQEEEFPWLQIPGKEKLKKKPNFRFRLTSPAYFGEQQRITKKIIWNAKYNRFYRNYKYRVPKLCAQSFTFPHPRREKDHHHQLNQFEAIWNVRKWNLNTSISNPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHA0</accession>
    <name>A0A914YHA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19697.t1">
        <property type="protein sequence ID" value="PSU_v2.g19697.t1"/>
        <property type="gene ID" value="PSU_v2.g19697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19697.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15025" checksum="441E81E2A3C5DB7C" modified="2023-02-22" version="1">MKNPYRSIECIDNERVVLKGPGEAYIHANFIKNLDGKKLFIGTQGPTRDSAPDFWRMVVQEKSTVIIMLCNIFEEDEKDGNIKEKSVQYWPSTVGKSFKYDDLEVSCLEIVEISYGVEGQIIVTTTLELIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHV8</accession>
    <name>A0A914YHV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1907.t1">
        <property type="protein sequence ID" value="PSU_v2.g1907.t1"/>
        <property type="gene ID" value="PSU_v2.g1907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027962">
        <property type="entry name" value="ERICH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1907.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13443" checksum="1FF5DC3AFB906C47" modified="2023-02-22" version="1">MADSLLENYNPLYDVHLRQYFALPHMQKHLRRMGLLDSNGVPVSQNGNVESELYARHHAMMDMMLRNRERVLMQLADLQKKYDAAEKVEIYRRVRVSTIFSGSQNLHKIQRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHX9</accession>
    <name>A0A914YHX9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19890"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YHX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1909.t1">
        <property type="protein sequence ID" value="PSU_v2.g1909.t1"/>
        <property type="gene ID" value="PSU_v2.g1909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1909.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46336" checksum="EC808436B551A38E" modified="2023-02-22" version="1">MLPNVNAEDISKLLDKLVVVKLNGGLGTSMGCKGPKSVISVRNDLTFLDLTMQQIQHLNNIYGVSVPLVLMNSFNTDDDTNKVLKKYANVRVQVHTFCQSQYLRINRETFTPLVKDLKANDHEAYYPPGHGNFYEAFYNSGLLQKFIDQGKEYIFLSNIDNLGATVDLNILNYIVNGSQKPEFVMEVTDKTRADVKGGTLIQYQSKLTLLEIAQVPKDYVDEFKSISKFRIFNTNNLWGNLAAIKRVIENNELEMEVIVNPKHLDRGVDVIQLETAAGAAIKSFRGACGINVPRSRFLPVKKSSDLLLLMSNLYDINFGNLTLSDDRSFPTTPLVKLGSQFDKVNDFLKRFQSIPDLIELDHLTVSGDVWFGRDVTLKGTVIIIANHGDRIDIPPGTLLENKIVSGNLRILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI90</accession>
    <name>A0A914YI90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19029.t1">
        <property type="protein sequence ID" value="PSU_v2.g19029.t1"/>
        <property type="gene ID" value="PSU_v2.g19029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19029.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24330" checksum="50FBD95603A8D592" modified="2023-02-22" version="1">MNPEEVRSGTNSPTNSPPPKEFSTPNSLPPIISSHQQQPQYPQYSSTSMSSIQISIPTSSIIPSSLLPSTATTTTPSPTPIMKAFHRAIILENSLFVAVKNPVLLSAYLQPPHDSKILEIALKNFQKISDKFSTFNNFFMFQYIESAGIILDPKMVEKFPAINHLINQSLQQYAEIMQIRMRNEFEFAALCQLSLLKITSEEFPQFQKILNKILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJH8</accession>
    <name>A0A914YJH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein BCCIP homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19470.t1">
        <property type="protein sequence ID" value="PSU_v2.g19470.t1"/>
        <property type="gene ID" value="PSU_v2.g19470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19470.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32132" checksum="74872BF1284790E7" modified="2023-02-22" version="1">MNDNTEAMEKLTFDFEAFPLDTGDVDGLVNLLTQIFLRTNVDCEAVAKALVEMSPLGCVYRPAEEVEDEDSENAVYGVLSMLELDGIAHFQTEIANLFLNRARKVATPDIVKKFEAIFNNKDNKQKNYLLVNERMLHFPDQIAAPAFKSLKDDLEEMKLLDKINNIIFVSKIRIANNAQAVASTVQNASGNGKKKLGKAEKKRRAAAALEAADVIFDNIEEEILFNNAGVLKPIYFQYSVENDVESDSKFHRIVKDGVTYLPYRRVTILSKDEFVKFVELVGQVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK65</accession>
    <name>A0A914YK65_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit SSRP1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YK65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1770.t1">
        <property type="protein sequence ID" value="PSU_v2.g1770.t1"/>
        <property type="gene ID" value="PSU_v2.g1770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="555"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="555"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1770.t1"/>
        </source>
    </evidence>
    <sequence length="634" mass="71967" checksum="B2D44580E5F9EA8B" modified="2023-02-22" version="1">MADNYDVQNVAKEEMGALYNGDMRFSLNGLTYKNRSTGKVFQLNNDDIETVEQNYMANKPGLRIITKEGELHRFANFTEGQLNKLKTFIATKWRRDVEVKENSLKGWNFGNVPIVGKNLQFQVNDALDFEIPLSNVSNCTANKSEAILEFHANEDSAVGLVEMRLHMPMVEGVSEEESPSELLRQAIMKYAAVEAETEQHIVLLTNMLCLTPRGRYDIKIFPTFLSFHGKTYDYKIPASSVNRLFMLNHKDGRRLFFVMHINPPIRQGQTRYSFIVFEFNKDELAELELSLTDEQLKDTYGGKIERHLNGPLHHIVAKLFRIFVGIKITVHGKFSLNDDTEAVTCSYKQSHGFLYPMDKGFMYVPKPPIYLRYEEVANVNFARSDVSTKTFDLEISVKGGSSFVFSSVAKEDFDPLLQFCKEKNLPVQNAKNLAKAPKGGFGLEDVDPYKERLKSEAAAADSEESDSDEEDEDFDVDMEERKKRQKDDDDSDATDGTEPDEEYDTGSAEEPGEEDEEKKKKEPSKRKEKRDNKEQSGGSSRKKGSEKKRKDPNAPKRATSAYFHWMSEIRASITKPGMGVAEVAKEAGRLWKEMSDADKKPYEAKFKEDKERYEKEMQAYKASGGGASSSAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKM9</accession>
    <name>A0A914YKM9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914YKM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17874.t1">
        <property type="protein sequence ID" value="PSU_v2.g17874.t1"/>
        <property type="gene ID" value="PSU_v2.g17874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47024">
        <property type="entry name" value="BIOFILM ABSENT ON HEAD (AFTER YERSINIA EXPOSURE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47024:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17874.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21023" checksum="688DEBCF976D2CD5" modified="2023-02-22" version="1">MIELNSSEGSGGNINDNQKQQKKLKTEIQSIERECPWAWATGCKWNSFVIDSYTTLGDIENNNNIIVTNQDKSSVTLQLIKGTDNYEDGISICIPPLYWYSDWLKLSFFIEVWRLSAGTNAHFYFYIQSISKTVEAVLKEYESQGILTIIEWPMLPNSTEENPNESIYRFGHLLAQNDCRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM15</accession>
    <name>A0A914YM15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YM15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19958.t1">
        <property type="protein sequence ID" value="PSU_v2.g19958.t1"/>
        <property type="gene ID" value="PSU_v2.g19958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19958.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8018" checksum="8868F9FED84D6065" modified="2023-02-22" version="1">MNIRPGRPGIPKIEIIFKVDENAILHVSAVDKRSGNSESIEIVSDKGRLSDEEIIQMSREIQIYPDEIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN72</accession>
    <name>A0A914YN72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YN72"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2085.t1">
        <property type="protein sequence ID" value="PSU_v2.g2085.t1"/>
        <property type="gene ID" value="PSU_v2.g2085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2085.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10331" checksum="CDC1FC072D065559" modified="2023-02-22" version="1">MKVIKAYRVASSDRLTLVVEVSSEPPALFEWFCNDKSVALNRQKFQVRHNLNVTTLTVENPAQGVYNCTARNPAGISKSYGYITVIGKLNIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNN7</accession>
    <name>A0A914YNN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2475.t1">
        <property type="protein sequence ID" value="PSU_v2.g2475.t1"/>
        <property type="gene ID" value="PSU_v2.g2475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2475.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="43419" checksum="5D2960BA6177F81B" modified="2023-02-22" version="1">MYKKYYETIEESVLVTEKPEFQELYARKIENAETASTEAEKYEQEIRKHKVNIRKELYWMDKRSEDKLKISEITESIEKMDPNLLKAFLRTMILGGTLSSNSDLSEATTTLSDSIATELTEFLKEMTKNRNRLFEIHLKKCLQIYFEDIKKISDEAADLQNEVRSLEINLMESKKERKKEQEFCDRLKEMIKIAEENAIKKKEKVKEEDDKSEKQWLKEIQDLENKFSEATKSRDKARIEKLNFQEEIRSAQIEENNLRHRFNIFQSLKNAEKEGRKKFENSQQLFEEEKCKNQNIIAETEIMSKILEEALKQETNLEKAIESNFIQESISEDHQALEAEKRELETELEYLILIEQKINNKNITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ70</accession>
    <name>A0A914YQ70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21179.t1">
        <property type="protein sequence ID" value="PSU_v2.g21179.t1"/>
        <property type="gene ID" value="PSU_v2.g21179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051595">
        <property type="entry name" value="GH25_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208">
        <property type="entry name" value="LYSOZYME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208:SF36">
        <property type="entry name" value="LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037432980" evidence="1">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21179.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18065" checksum="324EC8C520ED011A" modified="2023-02-22" version="1">MSFFAVTPVVFVALIFFHVTTGQNYNFAVDISVAATPADYQCLYQKGYSAAFAQAYSPANGGSLNPNVIQNLYNSMKAKLGGEIYVTPTITKDGKTQFDEVFNAVTAAGLEVVTIWLQVTAPITWSNNIQNNINIIQSFVDRALVSFKFYNFDIINFEVRKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQZ0</accession>
    <name>A0A914YQZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21498.t1">
        <property type="protein sequence ID" value="PSU_v2.g21498.t1"/>
        <property type="gene ID" value="PSU_v2.g21498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21498.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19193" checksum="0730887646858422" modified="2023-02-22" version="1">MIRRLCLFEHQTTILSFIRGSSNSTSSAATFDLWNNFTPAAIVERAPPKTQPYLKLIRLDKPTGIIGPYLSHMIEIFLGTFLLFWPASWGITLGTSASTIPDLKIIAIFATGSFLMRGAACIINDLWDKKYDQQVQRTCNRPLACGDLNTKQAIGLLAGLLSGSLACLLQLDATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR38</accession>
    <name>A0A914YR38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR38"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2641.t1">
        <property type="protein sequence ID" value="PSU_v2.g2641.t1"/>
        <property type="gene ID" value="PSU_v2.g2641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2641.t1"/>
        </source>
    </evidence>
    <sequence length="688" mass="79609" checksum="969108C99AE52FDA" modified="2023-02-22" version="1">MSSAQEIEDYVNGKIDEHLFLTRIVQDIHLDDKKVLSIVESVCASLNINLRHEIESNSNRLVEQAGSIDTLDSMQRMLHSEVNDAARNATEIGKKLQENFTSFNNLLGAMKNLRLIRRILYDEVTLKELIVEWDDVDFTRQADVIREIKNICSENDNLTSLSWYSSNIRPTVEKMDKDTRKNIIKNLYDALDRNDSLTVNHAVVSLYAMDSEEAEQEFTKIIKKAVDEIDGILKNLSELKEDSEVHESLEKSGLSVKLDQWFAQFQLIGSDVAKRFTEKLGKLISYRLSQYSPSVIYILNVLHSCGNRQRSDVKSVITDSLSAIDNLYTSERYSSMIDAVDIMFKEGLAQRGTGFLGISELFIDELKKCRFDPQFHEAMQETVRRVIMYIANRAGEIIRTSNHQWSFGRRMSNVQTQNYNILNMIYHLSQHYRNGAVHLQPLLDFYKDKCMTSIKTTICMVLASMLKEDIMNLPTGISPYMIELGDHLAAFSRHFRSLQMLNLSVEETHNFVTFVFEQFLLHISLVRPVNSATAARHANDLRSLINVFLKHFSCRTSNYINSRVQFIKFIEELPESIKGNTSIKGTIPYWFLIHIIITDHKELPMPYSSTEMSPEEYTAWFRKETESHLIDFYHTLVSSITYKYKDLEKPIFISELKNIIETWKDTVTAFESDENTMHNRNLIKHENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR55</accession>
    <name>A0A914YR55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR55"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2497.t1">
        <property type="protein sequence ID" value="PSU_v2.g2497.t1"/>
        <property type="gene ID" value="PSU_v2.g2497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="98"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2497.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38630" checksum="05D003CFE2F1D37C" modified="2023-02-22" version="1">MFSIVLKCVLSFEDSKDEDDVYTTIVKIPGTDAWEMALQGKEKIEDLNFAGTPLVESIVSMHKTECDFYDIIGKHVSEILPRVFQTQEWKIGEHQGCLHMEDLSKSGKNLDFYNSLSHGQLKNIVQRLAYLHKNIICLDEKIWKGKFLKQKRIFIGILPTVKQFSLKFLEMSKKTTVLQEIYCNSKIQKIIYNEKYIEYALIQSHLDAGIPDLLVHADLWSSNIIFVADKDGNPTDEISAILDWQVVHEGNMLLDFVRLMLNSLDGDTRREAELYIFDFYIDELNKYLATVGKKIPYSVEQVKKAYEYYFGPFFTYFNDARSNFGFKNSRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRG0</accession>
    <name>A0A914YRG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRG0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19969.t1">
        <property type="protein sequence ID" value="PSU_v2.g19969.t1"/>
        <property type="gene ID" value="PSU_v2.g19969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="352"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19969.t1"/>
        </source>
    </evidence>
    <sequence length="708" mass="80991" checksum="F19FCB4657A6E6FB" modified="2023-02-22" version="1">MDLSTLTKDFEMRISQAEASQSLNRSTPVPRPNKNPDQELMRWRFLTLQSDMEERKISHDKGLISTRTTILSGDIHSCKRAFEELKPITLRDMKVPMVHEGRYLICQVIGQPYAIVGVNVLIQDINGDVEEVAIYNFRYKLDKLDWIHPGTVFIIKEPWLRYGSQSKTPSLRIDSPSDVIFIDSTDYEFLNKLDAKKWYVSMSKDAELWREKANKCFKKQEYGDALIIYDRAIRYNPENAVLYLNKSLTCLKVDAFYMAYQCAKEALEKGGDKEKALFRMGQASYGMREWQKAAKHFTELLQEFPNNKAASEQLKLTTFRLAEERNGKFNFKKMFLDSKKEKAQLDVADYIGSIKIAEIPGKGRGIIALKDVKAGTLLAVSKAFASGYDQDFDGILLTINLIRKDGGTAAQMLQVIQAMKNLQNNPKRAEEVYALYAGDTVTRDEKIPFGIIDAARIQQISALNRFASDDLPSDFNFGNIPELRDNSHLFILPSYFNHSCLANANRTFYGDVMVIHATVDIKKGDEICLSYVSPLLEYSERKKKFQSWKFTCKCQLCEIDSNDKFISKRHQMVTEFSVYARANMGTPKLVIAKGEAVLKKLRETYIQRNKFKIHLAQMLMMLSPAYYANSDPMKAIKYLQEVINLFDNTPLKYVISIADACVNLAHCYLSIGNVTKVKELIQKASELCCCTDMEHFNMLFPELVQKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSB7</accession>
    <name>A0A914YSB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Structural maintenance of chromosomes protein 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2906.t1">
        <property type="protein sequence ID" value="PSU_v2.g2906.t1"/>
        <property type="gene ID" value="PSU_v2.g2906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="134"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2906.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42882" checksum="8AB0CEE3AFBFC791" modified="2023-02-22" version="1">MKKIIEELKSLKSKDEEILQAVLRKQEENTAVYDKQGEKIQEIVNQGKDLAQKMVKVENELEKLRSEFDAFDKGTGKLHTKKRLHEARIIKQNELKKDLLAEKEILLVNLADAEKYEKPDNMNDPPDFDALIEKDDCEKQIAKLKSDISRLTRINEGRTVTVEELEAAKLEYEKASETEKQYSKKLKKVEKAFHKREELFTKVKGELPIKLRQKFCDLMNMRNYVGHLNVDHENKTIEIKVETHRDANKGNWEDSGEDEDARGRRLSAAAVSNRKTQRIAQDLKGLSGGERSYTTACFVMALWSCLESPFRCLDEFDVFMDMVNRKIIMGLLSDLARQHKHIQFFFFTPQGVSELQAKDVEVFTMAPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSQ6</accession>
    <name>A0A914YSQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">UV-stimulated scaffold protein A</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UVSSA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3190.t1">
        <property type="protein sequence ID" value="PSU_v2.g3190.t1"/>
        <property type="gene ID" value="PSU_v2.g3190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018610">
        <property type="entry name" value="UVSSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049431">
        <property type="entry name" value="UVSSA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049408">
        <property type="entry name" value="UVSSA_N_a-solenoid_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28670">
        <property type="entry name" value="UV-STIMULATED SCAFFOLD PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28670:SF1">
        <property type="entry name" value="UV-STIMULATED SCAFFOLD PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09740">
        <property type="entry name" value="DUF2043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20867">
        <property type="entry name" value="UVSSA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UV-stimulated scaffold protein A C-terminal" evidence="11">
        <location>
            <begin position="400"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="547"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3190.t1"/>
        </source>
    </evidence>
    <sequence length="612" mass="70567" checksum="53E385978E46F72C" modified="2023-02-22" version="1">MSLGNVEEVKRTVRNLIKKFDYDKRELNQPLLKKVKDLIKRDAQLIPEFVDTIFINLKSQDSDKRLCIVLLVDYFFNAHMHFELQLLILYNRIGSIIFSTTWSTSSCNNPKKETLQIFKLWVEKYVSGYPKLENAKTVLLSSKTFDFARSDGQTEVERKRAEEEKIQKDIIDKKIIDQILIDFAESKAHVKESVVEAQTMISLIVPDFREYQNVSSPEAGPSSSSSTPTVTSRNLVISVPDKIIVEKNDDNEELINAFKDNQKLLGPNLKKVNNWISKMTRHGGNGEILKEMLDLQRNLNQEIQKTKDVKIIERRKAVIPKAAMEDGSEDDEDSDGFEDVDLNVADPEGLGSDEERGKKDEEITVEQELLEQISEMEKRETLEKLKAKKDEPSSSKKKPEVPTLNYGLDLKYWGEDVKPAEVAKNQFDGHRFWRPPDEDQVGHESEDVYRTRVITFVGEMPEITHSCRAPLPSGRLCPRMDRVNCPLHGPIIDRDENGVIVGVHPKQQKGTFLTANQKFYAEYERKRKEDEEDALYRELEKQTDGKFSYQIAKGKKKKKDAPKKREKSAHQKTRDRLSTKILNKRSLKRVTDHLDAVQKNKAAKKFAHQFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTP7</accession>
    <name>A0A914YTP7_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3367.t1">
        <property type="protein sequence ID" value="PSU_v2.g3367.t1"/>
        <property type="gene ID" value="PSU_v2.g3367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3367.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13494" checksum="1C374E37D12E1E36" modified="2023-02-22" version="1">MSSDAAFDYSDEERVTIVSQKHQNYPESSSSSIGGGAPIIQSLILSEKGTTSTFRSPPSSSSFSAAAAFTSNEKYFTKEIEVNGKLMRFDSSQLKNEEGCLKISEFIVIVIALLLSGNVMVRGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU14</accession>
    <name>A0A914YU14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3638.t1">
        <property type="protein sequence ID" value="PSU_v2.g3638.t1"/>
        <property type="gene ID" value="PSU_v2.g3638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3638.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8014" checksum="EA99DC40F4DB593C" modified="2023-02-22" version="1">MADNEVPSDEGEIAQLLFDDTFYNPALKVSNVAKERGAVKKLMKFDEFPIYIARPFVETFAEEVGTFFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUR5</accession>
    <name>A0A914YUR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUR5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4361.t1">
        <property type="protein sequence ID" value="PSU_v2.g4361.t1"/>
        <property type="gene ID" value="PSU_v2.g4361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036940994" evidence="3">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4361.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="12152" checksum="8B66B2E91F895989" modified="2023-02-22" version="1">MRLLALSLLLLLQTFEYSESAACKGCAPPCICPGTKGEKGLPGFQGERGHPGSPGTDGPEGPLGAPGMQGTEGDYGDAGPKGVRGDRGLPGSPGRPGNAGLDGLIGSKGELGIPGCNGTDVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWK5</accession>
    <name>A0A914YWK5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="11">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for normal Golgi function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Golgi apparatus membrane</location>
            <topology evidence="2 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWK5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4351.t1">
        <property type="protein sequence ID" value="PSU_v2.g4351.t1"/>
        <property type="gene ID" value="PSU_v2.g4351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="60"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="198"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4351.t1"/>
        </source>
    </evidence>
    <sequence length="648" mass="73660" checksum="8FABFF08D2348409" modified="2023-02-22" version="1">MTEGKALKAEIEQLVNAQIHNDENFANGVQYLQSLLPASQEYDEDVEEKPKRLIRPVAENRRVREILEQREMELFESFSQQFAQMNDQVQGFVSKIQSMNDICNDLSNRIQSNKEKTRDLLRKTSILQTEKKNLQAKETYLNEFFDKYSLPADDEKALSVSNGTVTESFFRAFKKLLEVIDRVNESMKVTPENIALSEISTNLEGKRSEAYNILFSSVQRECRLLNAEFLELKPILYQSFEVLQCKENLFSAALDEYSNARRGYTVHAFIDALTKGNKSGTQRPIEQFSNESLRYINDMLAWIHQELEVERELLGTLLKKCKPETVHGLTKTILATISEGLCQPLKLRVEQSLTRETNCVVLYRLSSLFLYYAKTFETTFGDTALLVKSLQDLHELASNMFFSSVTSTVQRILGNMTVPDYDLLPVNAINQTLLLLRDILESQNDGAFTAVIDKKEMYTKIFGLILDPLNQSIQLVSSNLSNHLDIAVYMLNCLNAIKSVIVLYQYTDNKLEMIKAQIDANEDVLVSEQASSILTNTGLIEFYRKAMAHQSNQGPLSKLSGMEPERIAGAIAMFNGFLEKPEGFQCHQCAKINSARSRESVQKRTFENVVGAYNVIYSKVIDPSNGYPAEMSLKTIEELNEALSKNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYA2</accession>
    <name>A0A914YYA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4618.t1">
        <property type="protein sequence ID" value="PSU_v2.g4618.t1"/>
        <property type="gene ID" value="PSU_v2.g4618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4618.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21291" checksum="4D1C68B914424ACA" modified="2023-02-22" version="1">MHASQIINVGGNRQQAGRESSMNIDETSHPNEMNPFAGEIEVEPQIPLSIKEDSTQGFTDEKFEVSDNEDKDEEPTSEYLIDVQHKLPQNLHIQAVIPSPQKQSQSRKKRPMQYMAHFHDGINQNLIMLPDGTFVIQCPWDLHQISSDETSPKILHPNSSVILKKSPVPVPEYLERADFISLLPNTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ46</accession>
    <name>A0A914YZ46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ46"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5220.t1">
        <property type="protein sequence ID" value="PSU_v2.g5220.t1"/>
        <property type="gene ID" value="PSU_v2.g5220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5220.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21531" checksum="C2656646580CBAD0" modified="2023-02-22" version="1">MLKSRTHFDPDISPQRPLTAPAMIESDESSSDDTYVVDDDDLQDSELQQKVRETSIDEIPDIPRDDEPAPPPNNRQQPQPESTPTPPESEIIKEENEKNDILRRLTKMSPPTESEESSEGSSTDGSEAPEIIGLKEELEKLGKEIEEDSGITRNPEPPKPPLRLPPIAPPRRTTGRLEFKDPLHTSVPRMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZE5</accession>
    <name>A0A914YZE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malic enzyme NAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5872.t1">
        <property type="protein sequence ID" value="PSU_v2.g5872.t1"/>
        <property type="gene ID" value="PSU_v2.g5872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051674">
        <property type="entry name" value="Malate_Decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43237">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43237:SF4">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5872.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18150" checksum="8DC8D146E0C52B19" modified="2023-02-22" version="1">MAPDPVIFALANPTPEIMPELARAARPDAIIGTGRSDYPNQVNNVLCFPYLFRGALDVGATAINEEMKIACVRAIAALARRAATDMGSAYGGDTPSFGPVGRRGPGRDGLGRGLAPDRRHGRLPRQAGPVRLPHQPDDEAGLRPRAQRQAARGVRRRRRGSGAAGGAERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZH1</accession>
    <name>A0A914YZH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mago nashi</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZH1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3433.t1">
        <property type="protein sequence ID" value="PSU_v2.g3433.t1"/>
        <property type="gene ID" value="PSU_v2.g3433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3433.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17514" checksum="6CC79893D854D545" modified="2023-02-22" version="1">MPEEKDNFYLRYYVGHKGKFGHEFLEFEIRPDGKLRYANNSNYKNDTLIRKEVYLSKSVIAELKRIIEDSEIMREDDMKWPEPDRVGRQELEVMMGNEHIAFNTSKIGCLVDVNASSDPEGLRSFYYLVQDLKCLVFSLIGLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZI1</accession>
    <name>A0A914YZI1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-alpha-acetyltransferase 60</fullName>
            <ecNumber evidence="7">2.3.1.259</ecNumber>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50604"/>
            <dbReference type="Rhea" id="RHEA-COMP:12745"/>
            <dbReference type="Rhea" id="RHEA-COMP:12746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="ChEBI" id="CHEBI:133414"/>
            <dbReference type="EC" id="2.3.1.259"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetyltransferase family. NAA60 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.259" evidence="7"/>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZI1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5505.t1">
        <property type="protein sequence ID" value="PSU_v2.g5505.t1"/>
        <property type="gene ID" value="PSU_v2.g5505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="59"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5505.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22811" checksum="8845A6E83DF81C98" modified="2023-02-22" version="1">MLSNCHLPSNRGNNINGSQNDLAQIIIDSPRDLQFATTSNSSNNNNNSSNNSILTANGWKIENVAVKDFDAVRQLCRDSFPLDYPESWFEEVVNGRFIAFGVYNGDFLTSLLVAELKRIGDCDPEDRELDTNPDSLVVYILSLAVHQLYRRKGIASILLDHLIKTVVDVPPYPKLVFLHVLATNYGAINFYKRFGFQHFATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z077</accession>
    <name>A0A914Z077_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphomannose isomerase type I helical insertion domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z077"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3683.t1">
        <property type="protein sequence ID" value="PSU_v2.g3683.t1"/>
        <property type="gene ID" value="PSU_v2.g3683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF2">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="1">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3683.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30881" checksum="72DA6F7272F3D985" modified="2023-02-22" version="1">MGETETKKFEEIIKNGSSQESKEAKEALKECFTKMLYSQINSPTLVSEQLKSFYERLKNGIRGALIEESIPVLESMNKTFPGDVGCFSPLYLNHMILEPGECCFYAAEELHAYLSGECVECVGNSNNTIRAALTPKFIDRDALIKVLNYRMTNPEFYLVPPQKLELYPNITEYAPDCKDFALHEIKYSATQQDLPDSKIIKLPPLQCGSIMVIIEGNGIYKSDEKIQKSFKRGDIFYIEPEKTIQICAPTFGSLIAFRTFSHETAPSLLRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z128</accession>
    <name>A0A914Z128_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z128"/>
    <dbReference type="WBParaSite" id="PSU_v2.g560.t1">
        <property type="protein sequence ID" value="PSU_v2.g560.t1"/>
        <property type="gene ID" value="PSU_v2.g560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g560.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22608" checksum="EC5D4E698CB21150" modified="2023-02-22" version="1">MERSRRDARRPARYQEDDPLGAGHQVRSRSSNSRTSGSTNSSNSQRYQAGRNGAQQAQNFLNRNASTPPQTPPPQTPPPQTPPPGTPPPGTPPPGTPPPRTPPRQQQNQQQNHNRQSPPRHRGQRNGIRRNVRFEREVFVVGYTADTVIACSSSDVDGDIIPQSEVYGLRHYFTLHTYFDTRDQAVNFAREMGQYKVIFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1X3</accession>
    <name>A0A914Z1X3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Golgi pH regulator</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Golgi pH regulator (TC 1.A.38) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1X3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6702.t1">
        <property type="protein sequence ID" value="PSU_v2.g6702.t1"/>
        <property type="gene ID" value="PSU_v2.g6702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051452">
        <property type="term" value="P:intracellular pH reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="11">
        <location>
            <begin position="116"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="10">
        <location>
            <begin position="257"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6702.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="49999" checksum="A7E31D8A72E9FEEF" modified="2023-02-22" version="1">MKQLFKDYEVHQRIVQMIFSVTFALSCTMFELIIFEILDVLDSRSRLVTWQVALYLMLCILIVFLPFYLFYLLTKSIFTNKPIVLSVISVALWLTFIYFFWKIGDNFPILSTKHGIFSIEQAISRVGVIGVTVMAVLAGFGAVNAPYTCMTIFMRPVIEEDVDLMKQKIRQNTSMIIAKKRRLIQLENDLKKSAFSLSNNPEAGFFRRVLGTVTNMGSGLKDQISTLKSEIEPLEEFGRHLFLEMVELNNMKDRMDYSTTWQGKYFNFLGYFFSIYCVWKIFICTINIVFNRVGKIDPVTKGIEIVVNWMGYEIDARFWSQQVSFLLIGIIAVTSVRGLLITLTKFFNAISNRKSQNLIVLLLAQIMGMYFISSVLLIRMNVPLEYRRIITDILGDLQFNFYHRWFDVIFLISALASILFLYLAHKKTPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2S3</accession>
    <name>A0A914Z2S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2S3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6648.t1">
        <property type="protein sequence ID" value="PSU_v2.g6648.t1"/>
        <property type="gene ID" value="PSU_v2.g6648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6648.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="18499" checksum="1E8C4A56BE7D7987" modified="2023-02-22" version="1">MEVTCEPNPCASLSGPRVLITETAAADCSYTAEATCTVSGLAQATIQFNGAPPNVAFPQTLTCNSGTGQYTYLMGGVPTVVNSIECICGPNSCGWTFSGGATLNPPQGVGAPINPPDMNCIYTLQAECTPATKTMITFGPPPLETFMVPKMITCPAGYTGYLYITNGGTESEIFGANCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3F2</accession>
    <name>A0A914Z3F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3F2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6561.t1">
        <property type="protein sequence ID" value="PSU_v2.g6561.t1"/>
        <property type="gene ID" value="PSU_v2.g6561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="50"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6561.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46525" checksum="2D2F29CD05CED654" modified="2023-02-22" version="1">MSSRPLTKADAELMEKLRKLRGGSPSPPPRPSTPFSDIPAQLKSEIIISSSFLNSCLNAGNLQSIVFSPAIISASLIMALYGADKEAIKEINDVFGQNLLCDNTSYESLIYFKSLIYSKKLSLLPPFTDYCNKNDSHLFPVDFDNLGQTIKEINSKVSEKTMGLIANILNDSQNIIIQDTSLCVASAATFVGQWAFSYPFDKPKSIMFYSNPPRQIDMIRQKEKELWMFSEGDDWTCMSIIYGEDIPRKLYIILPKKVDGLANLIKKFDYSLIRQCINGTNVLSAATIPLFQIKSTMVLNDKLKDMGIKHLFSENAFDKIISNDNPHGLDLFVHAARIKVDQFGADGRDDTADHLRYEDLRIQPGYLIPPPGCEEIEFVVDRPFIFFVALWKVFEGQDSKPRLHSIQFTGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3N3</accession>
    <name>A0A914Z3N3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3N3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4860.t1">
        <property type="protein sequence ID" value="PSU_v2.g4860.t1"/>
        <property type="gene ID" value="PSU_v2.g4860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF248">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4860.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28613" checksum="7111BA542FB95A9D" modified="2023-02-22" version="1">MFHLFCLYLCITTVPIHFIYRCNLIVRSRELSITFFLAMISVPICFTLAYVLLFAHSIVPRSDTFEKYGKFFTDANWYDFDGKIPTFYAAPFTNENGKQIRVVASFLVLIPYTIAALCAIAITIKLKSVEKTMSPKTRQLQKQITRVLLIQAMIPLITLIVPMGLHIAATEMPITSFIAMITLSWSPVFNPLVALIVLTPYRRALQNLFFNAFDAAQGISSFHLSMSSTNSTLLLRAPQQHQQQKLVNSNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z472</accession>
    <name>A0A914Z472_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine kinase</fullName>
            <ecNumber evidence="2">2.7.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.3" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z472"/>
    <dbReference type="WBParaSite" id="PSU_v2.g715.t1">
        <property type="protein sequence ID" value="PSU_v2.g715.t1"/>
        <property type="gene ID" value="PSU_v2.g715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004054">
        <property type="term" value="F:arginine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07932">
        <property type="entry name" value="arginine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000006">
        <property type="entry name" value="Arginine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000003">
        <property type="entry name" value="Three-domain arginine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF20">
        <property type="entry name" value="ARGININE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="9">
        <location>
            <begin position="50"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="10">
        <location>
            <begin position="161"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="164"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="324"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="352"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g715.t1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45266" checksum="325919DE539FC9A6" modified="2023-02-22" version="1">MAAIQKRLVVGGLAGLIGVAGGYGIVYPYVRDMVYVNEQISENNAFNIKKIENAYKTLQEDSKCNSLLKKHLTQDVVDKLKYKKTKLGATLYDVIRSGVFNPDASVGVYAPDSDSYKVFSALFDPIIQEYHGFGPNDKQPDVDLGEGRTKELEPLDPDGKYIISTRIRCGRTLRGYPFNPLLTGDDYLIMQEKIKKAFEQFKDTNDLKGTYYPLSGMTKEIQQKLIGDHFLFKEGDRHLQHANACKYWPKGRGIFHNDEKTFLVWVNEEDHLRLISMQQGSDVGNVLDRLIRGVKTIESKVSFARDPHLGYLTFCPTNLGSTVRASVHIRLPKVSTRKDFQEICDKLNLQVRGIHGEHSESEGGVMDISNKQRLGISEYQAVRQMYDGVKKLIEMEKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4H2</accession>
    <name>A0A914Z4H2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4H2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6791.t1">
        <property type="protein sequence ID" value="PSU_v2.g6791.t1"/>
        <property type="gene ID" value="PSU_v2.g6791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6791.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9307" checksum="68B6094A8771436B" modified="2023-02-22" version="1">MGNKQSYNVTDANANANSSNDDKVESEVAYTFDSAAKGITMKKSDNDDKYIQQEILYRIDPLPDMPFIPVATTTTEVQEREIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5T5</accession>
    <name>A0A914Z5T5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5T5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g727.t1">
        <property type="protein sequence ID" value="PSU_v2.g727.t1"/>
        <property type="gene ID" value="PSU_v2.g727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="54"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g727.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25713" checksum="69099E6A4122777F" modified="2023-02-22" version="1">MLCFLYTDDCEIDSGNVWEMLNMGDTYDISLLVEKCLKYICESVNKCNVLEYSQKALIYDKNSMIMKKCWEIINNSYDYVITTEAFLKISPELLVEIAEHCIRDNENLFFDQVIAWSRKECHRRKVNSTVANIQRLLTDIKPKLNFEQMDIYNLVTKVRKSGLLSSKELLDAIQQVATEQRTRKRQKQQSEIDSLNHQLSLDMDFLERWQVTPNPTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5V6</accession>
    <name>A0A914Z5V6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5V6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7722.t1">
        <property type="protein sequence ID" value="PSU_v2.g7722.t1"/>
        <property type="gene ID" value="PSU_v2.g7722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF125">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036677759" description="Sodium/hydrogen exchanger" evidence="11">
        <location>
            <begin position="18"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="10"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7722.t1"/>
        </source>
    </evidence>
    <sequence length="498" mass="55810" checksum="18FB0CF1043324F6" modified="2023-02-22" version="1">MVFILAVKLLFHSRAQGLKMPDSAMMIVAGFCVGTMLDWFLPHDVYLDPDLFFLYLLPPIALEAGYFMPNRLFFRNIGTILTYAIAGTLWNIITIGLTLYLFSDFYKIKIAFIDLMLFSTLISAVDPVAVLSVFTEINVNELLYICVFGESLLNDAVTIVLYHALSSMAIIGSEHLVLNDFLRASGGFFLVAIGGILIGVIGAAATGLTTRFTKELSHSQPLVCLLFPYLAYLIAELGHYSGILSIVVCGLFMKPYVRRNMGEDATITVKYFLKTIASHSEAMIFIFLGLSTFSRNHTWDPWFIAVTVASCFIYRFIGTYLFSAICNKFRVEKIGLVEQFIMAYGGLRGAICYGLVMTLDKDSIPAKDMFVSTTVVMIVVTVFAQGSTIRPLVHFLQVKKKDNHVPTVTEIMVTNARDDVMEGIEAIAGIHGQYFWRRRLSQFDREFIRPLMTEKMSSRGDELVEKYNRVKSTSSQARLIQSLNLINNDSSDPLSNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6N1</accession>
    <name>A0A914Z6N1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6N1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8344.t1">
        <property type="protein sequence ID" value="PSU_v2.g8344.t1"/>
        <property type="gene ID" value="PSU_v2.g8344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8344.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18522" checksum="6C6566C16A6F55FB" modified="2023-02-22" version="1">MMQFEVTQPLLNPNNSSINNQKEQQDESMSTSDAVASPPSLPPLLSTTNSIEENVIEDSIIIPTKDLNVSVKLEIYNLIQLLSNCIGDISGDKKISLDEMDEYNVELKKCLASIEVGLTEQMNIMEESLMSTDVNCCRALYDHQIEAMNEMFKEFNELIEIQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7A8</accession>
    <name>A0A914Z7A8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7A8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6133.t1">
        <property type="protein sequence ID" value="PSU_v2.g6133.t1"/>
        <property type="gene ID" value="PSU_v2.g6133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF12">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="4">
        <location>
            <begin position="281"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6133.t1"/>
        </source>
    </evidence>
    <sequence length="388" mass="42145" checksum="9F004C531878AEBE" modified="2023-02-22" version="1">MSQHFDEEQLRQLWTYALSAVVPFAAVVTVSLTQCKPKKKPDAPPPAAKAGDPSKSKMAAAPGAPPAAAAAAGAKDEAKSKKDDVKKDEPKKEEGGKSKKEDVPKSKKDEKKEEKSKKDEKKEDAPKSKKDENNNEPPKSKKDEAAAAGDDKKEKSKKEESKAGEKKEGDEKKEGEEKKDEEKKEGDDKKEGDEKKDEKEGESKAKKPEDEKKEDKKDDDKKEGGDEKKDAGSKKETPSKKEAGSKKEAASAKKDAGSKKETASKKDGASKTGNAPGDKKEVKMEPKELKFAKAGGSLKVKLTNNTGERQAIKVKCSDNVLYRVNPVFAFIENGSSTEIEVIRQTGNPKADKIVIVHTPAQASDTDAAPLFKKSEAYPTFLLPLQVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z810</accession>
    <name>A0A914Z810_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z810"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8005.t1">
        <property type="protein sequence ID" value="PSU_v2.g8005.t1"/>
        <property type="gene ID" value="PSU_v2.g8005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037961963" evidence="2">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8005.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22924" checksum="64BB21868D82E906" modified="2023-02-22" version="1">MIKKYLKILLFILAILFSFCCFSNAAVPAAAPPAAAPSIVKITTTPAPVKSIPNVIDNFTKNFNGKVKALESWIPLGLWLGVLLAIGFINLFFIVPIVDDIIFGLAKTLEDRDHFLAKCVKHHSNIIFVARHNSLSLNQVQRKYIINCCILTCYDGCHRSTLKREEKRIYQNLNARCEVLEVYSKLESTNAGPTTTGEGGDTKPSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8M3</accession>
    <name>A0A914Z8M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8M3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6595.t1">
        <property type="protein sequence ID" value="PSU_v2.g6595.t1"/>
        <property type="gene ID" value="PSU_v2.g6595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF22">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6595.t1"/>
        </source>
    </evidence>
    <sequence length="561" mass="64889" checksum="3F03620C491BE65D" modified="2023-02-22" version="1">MYNDGNGKYIPISELVMIRNKQRNAILSALRRKKGHGKSGPNILEDFDQTTQAKGDFSKALKLLDGFVNSNRNIKYRLVTWDLNEKGKMGENLLNLCLLHNTAEHNTLAIKLVQHFPKMINDIFVSEEYYGLSPLHQAIVNEDIQMLYFLLKHKADVHQRCYGSFFCADDQKDTRSDSLEHEWVDVQPNTRYTGRMYWGEFPLSFAACTRQPDCIRLLCAFKADPNMFDVIINIEKLTLWSCRDTVCTAYPLRGIDTIDEITGQLNQSSVLSLVVYGDKSNHLDFLDNLLDDLLQKKWEAFGMRKLIHSIIGYTIYLIAFFIAFLIRTPRAPYEPFYYSNGTYSDQNSTMHFFTNSYFGLNEHLYQDERCYLWSYSDIPGSYLQRIRLICELIAVISSLIQFGHEAREIIHSSHKRWWQTTKAFPGKIIHKTSFLIILLMVPIRFACSLSEWAVVVENVLGIVAALTTSMHCLFFFRSPGEGILRMFIMSVGEFTAIYKNLQSCQSIIGTQGKVVFLIYELLVTVMLLNLLIAMMTRTYERIAETQKEWKRQVSNNCDNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAD8</accession>
    <name>A0A914ZAD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8887.t1">
        <property type="protein sequence ID" value="PSU_v2.g8887.t1"/>
        <property type="gene ID" value="PSU_v2.g8887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036929343" evidence="2">
        <location>
            <begin position="20"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8887.t1"/>
        </source>
    </evidence>
    <sequence length="597" mass="66922" checksum="E58158667008852B" modified="2023-02-22" version="1">MRSLLFSFILFLLIIFANARDILDEEEARDVQRYCDKYASCRKSARQQFEKCAGGFSKMIVAQTDTLRIKPSSRSGKCEKQLLLNIAAQIKPVYEKIEQDTFECTKSADPNAFNLDQSQTLICKAIQQEVGLDNFAINGAQGDTECRNTYESQMQRCDLVKECCPQFTHCHTKAELETNVYGKEEKLATQLDECIGYSQGSPKSGSYKHEEIRKSQASKTPESSTTPPEADEASTATSIPTLPPPEKVFNDLVKALFPGLVPSSTAHPSPSAEKSSETEAATTTESIFEKVNEIRKKQASSEKYGLGTLSEISQWKAVHDKLEQLKAKSKAKGLTASTTTTTTTTTATKAIPVPASTKPPPSTEPEIEFSHDSFISRRRSRIHTSPLIGKDSIAFDSHQKEALSRVYCENLMECEAVVETQFDLCDQRYKPEDDLFGIAKQSLRAQFLSNSNVTDRKVKRRCLEAVDPESQRQLSMLETFVIEQNHKCTRKAAIPSITSDKFEQCQNVHLISVISEMFTNKNIPEGKTPENAEKCYARVGQLQGICNTIRRCCPQNSVCANNNHSSEYAKYREIIEQLKDEQTLCEKRRMRILNGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAP9</accession>
    <name>A0A914ZAP9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZAP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8841.t1">
        <property type="protein sequence ID" value="PSU_v2.g8841.t1"/>
        <property type="gene ID" value="PSU_v2.g8841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF22">
        <property type="entry name" value="GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8841.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39346" checksum="D22589DFD17AF8D6" modified="2023-02-22" version="1">MVFVEGIFVEACKNQLDDVEALEYLKSQNFDLGIAESFDNCGFGIFHAIGLKKVVTIFTMPFPDNLSSKLGLSRSGSFVPSLIGGTDVEMGLFGRLKNLYRLWHTDSMNIIGLDCGVEKVIQDKVDPKFTSANAIAQSSFIFINSEEHLDFPRPITPKIVYIGGFNLDSKHRENDELNALVADAKDGFVFLSFGSVAQSSQMPLKMKQEILETFKQFPNIKFLWKYENETDKIADGFSNVITKPWFNQPAIFDHPKLICFITHGGMNSLVELSYKGVPAISVPLFADQYRNAHLLKYRKTGLVLTKDKFNAATLSKMIKQMITDKSFKENAVKLSKMMNSKPFSAKEKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAT6</accession>
    <name>A0A914ZAT6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="9">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZAT6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9777.t1">
        <property type="protein sequence ID" value="PSU_v2.g9777.t1"/>
        <property type="gene ID" value="PSU_v2.g9777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="11">
        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="10">
        <location>
            <begin position="361"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9777.t1"/>
        </source>
    </evidence>
    <sequence length="536" mass="61469" checksum="A74CD7EB879B8608" modified="2023-02-22" version="1">MDNNNLKSVADIYKDQCVFVTGGSGFLGKVLVEKLLYSTNVKSIYVLIRPLKGHPAKERLEKMLHSPIYDRIRQSDDQLFHKLIAVSGDLMHEDLGLSQAETLELCENVSIVFHCAATVKFDDILRASVQMNLIGTRRLLALCHKMKNLISLVHASTAYANCNLPKTQEKVYTPPVQPKQIIQAIEWMPDDMINTVTPQLLGKRPNTYTFTKALAETQLLEDAKDLPVIIIRPSIIGAMWREPLPGWTDNLNGPTGIFTAVGKGVLTNMCGSGNSKADIIPVDIVSNMLIVAAAHRATTSYPEIPVLHCASGALNPLKWGYIVIFLQKFYALYPLDQCSRPPSTCFHTSRKLFLFNYYYKHYIPAQILDLAYRAAGKKPSFVRIYSKIWKMVETLHYFTTRGWEFESKNILTLWDSLNAEDQKVFNFDIRQVNWDDYLFDYVMGVKVYLLKESLDNLPAARANLAWLKQVNLYWNAGFWALLVRMFAWKRTRTQKWSMWFLGFMATHVFQNYDFRPAVHMKTLDEYKRTTTLVKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC50</accession>
    <name>A0A914ZC50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7824.t1">
        <property type="protein sequence ID" value="PSU_v2.g7824.t1"/>
        <property type="gene ID" value="PSU_v2.g7824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036880204" evidence="2">
        <location>
            <begin position="26"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7824.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27775" checksum="A83F2346B905C9F7" modified="2023-02-22" version="1">MNCCCFKSFFVFFCFQLLFFDPIFAAKLQRRENSSNDSFILDGNDTVNEQQLHSDILLADGSVNGIPDGNDIRLSGYGSINLTLTDGTLQFEVCESCRGRSKVCFDTARVHSKAQCAEYSSYCKFEVKYEKDKDDGTESIFFNGLPKIIFKGDCLRPTMNWGEVPSIGIIGFKSCEPKTDGVDKMIKLYADIDASCPIKVLNAKVHVPQILSTIPPSNLSSTDSSETAVPVWAIVIMAVLGGIAVIIIIGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCJ6</accession>
    <name>A0A914ZCJ6_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCJ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7978.t1">
        <property type="protein sequence ID" value="PSU_v2.g7978.t1"/>
        <property type="gene ID" value="PSU_v2.g7978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7978.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17979" checksum="9522A87A95673287" modified="2023-02-22" version="1">MQKLIALPMTRYKNLTNNEKPQSGWRETIDATMKNQENQELLQRQRYYEETQEEMPKNHNKVISQKAVAWLPPPSRINKYLKQYKKPTLDDLFGLKSRKTKKIGVPKQLVIKKKPAIKEPDTTKLSLKPTVPSKPPPFKFNLNDPNAFHRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDD9</accession>
    <name>A0A914ZDD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Subtilisin</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDD9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9960.t1">
        <property type="protein sequence ID" value="PSU_v2.g9960.t1"/>
        <property type="gene ID" value="PSU_v2.g9960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9960.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11165" checksum="EF0CF004B99594EB" modified="2023-02-22" version="1">MSAQNIFKDYIPKEITQQSEFLKKYPNFDGRDVVIAIIDCGLDVSLDGMQKTTTGRPKVIDCFDFTGAGNVDTSVIKEFNNNGFNKSITGLSGRLLNVILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDZ9</accession>
    <name>A0A914ZDZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8500.t1">
        <property type="protein sequence ID" value="PSU_v2.g8500.t1"/>
        <property type="gene ID" value="PSU_v2.g8500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009138">
        <property type="entry name" value="Neural_cell_adh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01838">
        <property type="entry name" value="NCAMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="108"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="202"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="298"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="458"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="553"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="719"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8500.t1"/>
        </source>
    </evidence>
    <sequence length="889" mass="99291" checksum="82633C5CF1D72D74" modified="2023-02-22" version="1">MYACEVQESWQPRVSPPANQLERLATGTDLYLVCQVSETEVGKDNVELLWYKDGTAMTRQKIRKNGFIQASLAFVKPTKAETGNYTCKATIGAENKEETVPVEFFERAGFVESESSIHPQEGENAKITCETIGDRLDEIFWLKNGYQLSEADERGYQFEDDYRTLIIPDFFGEKDDGNYSCNVVQFAQIYSKDISVTAYARPVITVFQVPENNAGFEGSSATFKCSAHGKPSPTYKWFKNDEDNSMVELNASDKYKIDDGLLGINYLVDSDAGQYICEAENEVGNSKQNTTLIIHRRPKIERMEDVTTVLGNSVELICSINSDSNISDAYFMFNKQKYAPHSKDTSISYETVTDDSEMETTTVDDSEEESEEAETATVGTSVSGEEEEENNDDEEEDVETRKRRAIIDDTITVEWRDEKLVLTIPNAQMSHMGRYSCHAENMAGTTYDAAKILITHAPVFTNVSEKYIRRQEGESAFLFCEVSAIPAADMSFEHGSSQVYPDGVNVQLESTNDKLALSFNSLQDSDFGTYQCSAKNTQGSAEPAVFEIIKIVPPKDPEAISCADNVYPNFAVCRLDGYDETKRGEWPTRFQVFYTNEEPTEEFDWENSATVTEASFVDGKSVKLTGLNTEQKYFARILAVNEAGEGELSGVIPFETTAAWTPEPVIDAVINCPDVCSVNWTIPNDRGAEITGYKLVFRETSAVQSEIEDSTTIATPEIIETTTDENDDDSAAENITAEDFTDGEEEDDESGDVREQITINVGADDHHVDLPQLLPLRNYELTIYAINEVGLSDPTTYYFRTTEKSGLATLFPLPNWAVITLFVIVGLVLAIMLDAFCCKTRHCGVLACLTSHCRNRRNRAPKDIEQGNASGEHRVLITTTEKQIIRNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE73</accession>
    <name>A0A914ZE73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MnmG N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZE73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g857.t1">
        <property type="protein sequence ID" value="PSU_v2.g857.t1"/>
        <property type="gene ID" value="PSU_v2.g857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MnmG N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g857.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="25164" checksum="DD5485EDADDD4C5C" modified="2023-02-22" version="1">MIHREHENDDSRETKQVLDMIMTGFYDVIVIGGGHAGTEAAAASARTGAKTALVTHHFDTIGVMSCNPAIGGLGKGQLVREIDALDGLMGKAADQAGIQFRLLNRRKGPAVRGPRTQADRKLYRLAIQSFIKEQSNLTVVEGGAADIIVENGLVKAVQLMDGTIINCASVVLTSGTFLNGLIHIGDKTIPAGRMGEKPALGLSERLIGLGFGLGRLKTGTPCRIDGKTIDWANHSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFZ0</accession>
    <name>A0A914ZFZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">P/Homo B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZFZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g92.t1">
        <property type="protein sequence ID" value="PSU_v2.g92.t1"/>
        <property type="gene ID" value="PSU_v2.g92"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000001">
        <property type="entry name" value="Furin 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF3">
        <property type="entry name" value="FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="16">
        <location>
            <begin position="430"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g92.t1"/>
        </source>
    </evidence>
    <sequence length="612" mass="67930" checksum="CC67631A52B99F46" modified="2023-02-22" version="1">MIIPDDNYFLFIKHNVRTKSSRKARRSLDRVLGNDGKVLKLEQQVAKKRVKRGYQKIVKRHERSSSRWNHHYGLLGNSIDEDFNEVPRQLTPFIPPNDPLWPEMWYLHRSEQFDGEMDHNVKEAWQLGYTGKGVVVTILDDGLEHTHPDIAPNYDPKASFDVNDRDEDPTPRYDYSDENRHGTRCAGEVASVMNNSMCVVGIAYNSKIGGIRMLDGDVTDAVEAASLSHSYLHIDIYSASWGPDDDGRTVDGPATLTKHAFERGITYGRGGKGSIFIWASGNGGKDADSCNCDGYTNSIYTLSISSATEKGNIPWYSEACSSTLATAYSSGATGEKMIVTTDLHHSCTKTHTGTSASAPLAAGIAALTLEANSDLTWRDLQHIVVRTSRPLNLRAGDWKVNGIGRNVSHSFGYGLLDAGGMVKLARKWNTVPQANKCVVTYPKAYKIIPHGSRLHLQLFTEGCSGNIDRHVKYLEHVQAIVTLKAPKRGDIEIYLISPKGTRSTLLAKRQRDNARSGFTDWAFMTTHNWGEPSSGTWILEIDNDGWDDAELTKWELVLHGTPVHIGDTGYSKESYTLNERSIDALHESNAISLSSLASAFFVIILTGILRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQ29</accession>
    <name>A0A914XQ29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vitellogenin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g10126.t1">
        <property type="protein sequence ID" value="PSU_v2.g10126.t1"/>
        <property type="gene ID" value="PSU_v2.g10126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.20:FF:000003">
        <property type="entry name" value="Vitellogenin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037587455" evidence="8">
        <location>
            <begin position="21"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="9">
        <location>
            <begin position="30"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10126.t1"/>
        </source>
    </evidence>
    <sequence length="1404" mass="161427" checksum="EC507FA64EC129DE" modified="2023-02-22" version="1">MFAKGILVLLCASLLALALAGSRDEPRHSYRAGHEYSYDYNGQIASSMSNGEQYSASRFRALVKLYFVSDKTVTVQLEHPQMGQWNEHLETPQELHKFDKFERVQITAEHLEKLNLPFQIRFTNGKISDIKFASGDLTFSENIKRAIINTLQVQLENPSESSEVATVKEEIDGYGFRLNETTIEGDCESLYNVRKVNLESSESNNVDTYNVTKSVDFSQCQYRPEFRYNYFRYAEPKEIIRANIDEKTAQKLIHSNPALDISSVYDFVLNGDRRQFIVKESKVLSRYTYEMLDGQRVRMDTYAIAQSTLKNVERKEASSDSMPSTKSAETLVYSDEFDVLRERFIAEGDDTYLKQSPYMKMTNAVSVVSTIMKRLLESSTKISVEGIDEQSTRYFTQLVSTLRLCTKNDIENIHQKLFENDEHDGIQKTFMQGILSDAMAVAGTKHTIDHLFKKIQNGEISSVKAAYTLSQLMNLRLVSTETINNLENLCQESRVKESEMLKRTCMLTYGALVNAMCKVGSPFKHSDKYTTTVMKRYCSSSTKAEISTNIINFYNSASSRRDKILALKTMGNMGLENTVTFLETIIQDWNIEKVLRIQAIDSLRQMRKEIPRKIQRILLPIFQNRREHPEIRMNALYQLVHSRPEKAVLDMIMTEMIREPNAHVKSFLNQLVYQMTKYSHELYDRETAMTLRSMLKHFRLYSEEEKTPLFTSKFYSTVVAVEHNQIHELATQLNFAALFSNDSSFPKEIMTTMNLLANNRMIPNTYQLGMHTQNAEHFIERLYNSMNEKDLDQLLVRGRRSIAEESVNFLKGLYNRMKIATRRFSSEEIAPMVLLYSRFQDMDTFFCLTDEESLPELVKTFIVDGQVDVSRWELDNFKFSWASASYQHEQKIKMPTIAGLPLLTTIRIPTLTVVDGSITTNFNDKQQEESSVRSARIHLKVEPKIATTVIIKMEVFSPLFTSGIKTLHSAQLRLPLNLVGKVHAPHWTPEIEIIMPTEEVRVLHLQTRPVTFFRTWPAKSGVFVEATEKTLIVESATTPLKEKRYNYVDPFLGLNVNVDAHWHASPLMASEKLFGDWLLSGENAFELKIQPTADSSKALKLSFKATGKKSKEIPDVKIPNFSNFYGAQTNEMLSDAHRDEEKLIHEQLKVASGKLHNFHHFVIKAETIKGARPHVAKYDLTTLCDNRMILCIARQNIDIDSEWTSKSTVELGMPELRGVVDGFPSQHFIAKIDTVFGSTEKSQITLNIYGRPSAQKIEMVKRFVNIRDEKNVEYDIEGTFNRAPEVLKPNDYKLIVENKLSPKLNHHLRSIYAFLAATQFVNMPQPELVEQEIKKSSQIIMSRFILDQNNCNMTISMPDNRKYQMNWDNNDDATDSNQAYGLFDKKLNAQLKMVNLLKLLMEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS57</accession>
    <name>A0A914XS57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XS57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1082.t1">
        <property type="protein sequence ID" value="PSU_v2.g1082.t1"/>
        <property type="gene ID" value="PSU_v2.g1082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1082.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29152" checksum="7EE649FA52491E44" modified="2023-02-22" version="1">MPDKEISLSTSSTVASINSFDIDIFTKTMDMAFLQQQQQQQSQSQQSQSDRRQSIPSTSTSSADQQFVALQQFMAMQQQLASQFAAIYSQPGGTLGGSLAGTGGAINPINLFSPLFGTAQSPTTPTSATSTTSGGSLKRESNDPLTPPSAKKSATTNYFSSFAIDSLTAAAKTENDSMNNIKDEIDDDRNEHDSSPPCGSDQSLKLSPEDKLSPGSDDCGKRNSKQRRYRTTFSAFQLEELEKTFMHTHYPDVFVRITLFRFKHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSK9</accession>
    <name>A0A914XSK9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="3 9">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="3 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914XSK9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10255.t1">
        <property type="protein sequence ID" value="PSU_v2.g10255.t1"/>
        <property type="gene ID" value="PSU_v2.g10255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10255.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30377" checksum="EEB287DB437770C7" modified="2023-02-22" version="1">MFEACVRGHIPSMEEMVHPSELVQLKRCILSSKRDALPPICTHNMVDDGSDPVLNAFRRTHLFNNNHDRVKVVFHPEFLSSVSPLIGLDYEDFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSVTSNLSGFGNFIEKYVDQHDNYGIFIIDRRFKSAGESCDQLAECLFKYSCLSRRQRVILRNRTERLSDLLDWKALGTYYREARRLALKKVYPDLELKLSQSVKKIGRPVSAVSTPNHSRPGSPHGSESDTSEQEERENIEFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUC0</accession>
    <name>A0A914XUC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUC0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10134.t1">
        <property type="protein sequence ID" value="PSU_v2.g10134.t1"/>
        <property type="gene ID" value="PSU_v2.g10134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039212">
        <property type="entry name" value="RBFA_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725:SF0">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10134.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24460" checksum="4254BB0A3BCF27A3" modified="2023-02-22" version="1">MLLRFGQNTIDDAILILNPGPKTKMRKLDEKKRKQLSLLYFENIAPIICEIPEAADSSVIITKVDTMNHLKEIKVWWRAYGNERDIKIKNLLESNMEFVRKKLSETMYHSNVPPLKFIPDRSQIIVEEMNQLFATADYGMQYRALSHTGAVLGSQKDSGIQNETKVEKVPRFVIAMKKRREEKKQQKVAEIEKNNSPSDISPQQLPGHHNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUI8</accession>
    <name>A0A914XUI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUI8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10631.t1">
        <property type="protein sequence ID" value="PSU_v2.g10631.t1"/>
        <property type="gene ID" value="PSU_v2.g10631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10631.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11673" checksum="A923DB7875D538DB" modified="2023-02-22" version="1">MSKETRQLQNQLSWTFGMQALSPLVISFGPLGYLAYTIMIEGTAFWSMIWFTTGFAWVPFTNATLTLCFVGEFRQKIMFFRKFNEPSSSVAAPNHSSALATALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUK3</accession>
    <name>A0A914XUK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10647.t1">
        <property type="protein sequence ID" value="PSU_v2.g10647.t1"/>
        <property type="gene ID" value="PSU_v2.g10647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF9">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10647.t1"/>
        </source>
    </evidence>
    <sequence length="596" mass="67760" checksum="E2173E452420816A" modified="2023-02-22" version="1">MGANQSLGTNNSEFVDSLVDISSIETPEVEFVFRLIDREKFFPPSGKSDAYKEGAWKGTDSNEPPIHISAPGIYTNIMENFDLKKRMSFLNIGSGSGYLSSMVGFVIGSLGVNHGIEVNADIIKFANETKERFINDAVISGFDWCPPEYYCGNAFNIKTDMKYDRIYCGARVPDGERLRFLKLLKIDGVCIMPYGGVFQRIRRASEKTFLCREISNVEFGDMIRPTTSEEIKEIEYVELPFATFPRSLFDITRASIRQNVRDVVGKQKKIFVNQKTSLPSTGYPRDASEDEMLIDHPQPPRLDESGDENIDHRVAPETNSEGYIIHSLQRHARVHIQINAIIDDDPFEAIQGHFETDSDSDNDDNNHNAEQENADNEEIDIRDGVPAQNIDDIMINAVAEGLIGNDEASAENDNEAQPAPAPFVNRRDFITVQMENRARARIRERFEDLIQARFGADGDIVERRPRGGRLNFIQITPRRNQSLPHQNQRGDDTSSSSSPSGIGRKRRAESSDSEDKRVKIEEKFFDPPTIFRQPYVRVAVLKDDIPDRERAQYDERLSICLTEFDEEFRSILSTFPIPRKLLCQLLFTYFEPNLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW58</accession>
    <name>A0A914XW58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11469.t1">
        <property type="protein sequence ID" value="PSU_v2.g11469.t1"/>
        <property type="gene ID" value="PSU_v2.g11469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11469.t1"/>
        </source>
    </evidence>
    <sequence length="319" mass="34208" checksum="9314CAEE62A9F201" modified="2023-02-22" version="1">MDSTTENSEFPTVKYGTTQDSTDVPSTSAPKASTTGNPEFPTVNYETTKQPFENTELPSTITPSQEENATTINPEFPTVHYGTTQDSENSTDAPTQPPKEVSTTGKPESPTVVYPTTAQGYTTRGQRSTFAASTESPQGDSTSTLNPEYPTVNYKTTTKSNGNPSTTVSENPELPTVHYGTTAKGSEEKTTTTLNSEYPTVNYGSTTKRFNNEPNGPSSAAPTQSTSGASQDATTPSNPEFPTVNYKTTTLAVEIPSTTPKKSASNPPQQQQSTTIEQEIVSSTLAEVSTTPSTTTTTTTKPHSKIDNKHFIQIFIIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWB8</accession>
    <name>A0A914XWB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11256.t1">
        <property type="protein sequence ID" value="PSU_v2.g11256.t1"/>
        <property type="gene ID" value="PSU_v2.g11256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11256.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17170" checksum="BAA688B58D1DE666" modified="2023-02-22" version="1">MFTVPMEENRNGVVKLVDFTADAVKTVINFFYTCEIETIESSEQLEELFRFSDKYDIAALKEYLEHESISKLSDQNVCMLLEMSVRSNAFNLKEACFSFLEECIMVGASVQGLEELDSGILKDVVISAMKKRQGACIPSVKDAGNINEDVGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX20</accession>
    <name>A0A914XX20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XX20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1176.t1">
        <property type="protein sequence ID" value="PSU_v2.g1176.t1"/>
        <property type="gene ID" value="PSU_v2.g1176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1176.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13469" checksum="D529F867CEDE9161" modified="2023-02-22" version="1">MLDLQSKNLGSDQGIPTLINAAASIDDVYALTWVSLILSSITSGSEGERSSWLWTVACALLEIIGGAVLGCILGGILWIFPSQELSYHKYRRMALLLSFSMATFFGMEFLGYETVGPFAILVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXD9</accession>
    <name>A0A914XXD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXD9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1119.t1">
        <property type="protein sequence ID" value="PSU_v2.g1119.t1"/>
        <property type="gene ID" value="PSU_v2.g1119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1119.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25887" checksum="745D3AB062E33727" modified="2023-02-22" version="1">MAEELGSHKIKLEQVEVALAADPNNEDLLKLKSDLEEIISVTQELYQISGNGESSRSSKNDELSNHKWKVGDRCMARAKNGQKCLAVIDGITQEKAAITFANNGTKEIVKLNELGIAAVVEEKNYVFQKKDGGISKKDWRLEKERRKVRAQKKEQRKKAIEEEQEKEKKTWKNFNQKALNKGFKGIKRIAASGSAADGPRLGGVAGSSNPKLVSSRTTSGLNWTNRGNMDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXP0</accession>
    <name>A0A914XXP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXP0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11294.t1">
        <property type="protein sequence ID" value="PSU_v2.g11294.t1"/>
        <property type="gene ID" value="PSU_v2.g11294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11294.t1"/>
        </source>
    </evidence>
    <sequence length="379" mass="41310" checksum="A70A09F72522C8FC" modified="2023-02-22" version="1">MILLRGGISEETKWITASIEELPIMKVEQLQPGIFYQFMITAVGPNGRIGKGVSSDWLQAPSIGSTGIQPNTQLQIKSQFNSDDGISALVSWPSIIPLPTVPPSLVSPSTFRPSSVGTTSPLTGIKVIPSLTSCHFQVFIENGTTFNTDTFEKDESEGFLLHNLAYSSDYKIKLRTFVPGDSNLFESITTWPLETLYQSISCSQVHGKGSLECDPEPVENLSIHVNQESASATIEWKPAVDSSKVLLYQLVYYPISSSSSSSSTSSSSTIKCSMEQISQYLSASTTKSTVILPTKSECKFEVKLITYDLIGREAVATKTFTFSPPVLDEIQANLAGFWIFIAPAALLILLCLIVQCARCCEKRSKKVAAMSKSAFPENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYU5</accession>
    <name>A0A914XYU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12389.t1">
        <property type="protein sequence ID" value="PSU_v2.g12389.t1"/>
        <property type="gene ID" value="PSU_v2.g12389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12389.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14893" checksum="3C8A700919583235" modified="2023-02-22" version="1">MNNSTEINYYTLLYEENIYVVIHMLLIFWIPATIVLVCYLIVSCWVYFNSKPLAFSIEHSRNSTCGTAIMSSSRIRIGTRTTALTGSTADNRNGNGGVSYHTGLDTVETIISKPTGVHFGEKKIKFFENYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ25</accession>
    <name>A0A914XZ25_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ25"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12466.t1">
        <property type="protein sequence ID" value="PSU_v2.g12466.t1"/>
        <property type="gene ID" value="PSU_v2.g12466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12466.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19872" checksum="67D1E5FBFDFE79FB" modified="2023-02-22" version="1">MNSGELWKIGFQDFTIVVDGEEIKVHKCVVAVHSPVFAAMFQPPMKEAIENKLEISDFSFEIVEKAVKLCYNRDLAPDISVEEAILLLQFADKYNMATIQNNLENYLTDKIILKNVCEIANCAAAVNASKLQNQCLDFLTICFSKKEFVPNMELLEKEFLITVLSNFSVHKSHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZB0</accession>
    <name>A0A914XZB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13286.t1">
        <property type="protein sequence ID" value="PSU_v2.g13286.t1"/>
        <property type="gene ID" value="PSU_v2.g13286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000137">
        <property type="entry name" value="DnaJ homolog subfamily B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13286.t1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46981" checksum="669545526DEE27C4" modified="2023-02-22" version="1">MVADANRDEALTCLQKAKEAMLAKDEAKMKRFIEKARRLDPSCDVKSFLTNGTYNSKPEKAEKAQQERSYSHDDHYEEPEMRNRRRSRPSPSRASNASAENPSSSQKSRSRSRSTSATRRKQQQDASEPVEYAADEVQSVERIRHCKDYYEILQVEKNCSEVHLKKKYRELALKLHPDKCKVPGATDAFKALGNAYAILSDSKKRAEYDQYGAEGARVSRRRNDFYDYDVGRGFEAEMTPEDIFEMFFGGGFPTGSVYRRRTHFQYRREEPQEPQSILMNLFHILPVIVLLFGGLFVQFLVGEPAYSLQREGDYIYLRQTRDLRVNYYVKRNFEQDNRGRVSQIETHVENEYVNQLRMRCYKEKNNRETMLWSAKMRGDNVLWQKAQNMPLPSCQKLQEVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZK3</accession>
    <name>A0A914XZK3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="3">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XZK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12391.t1">
        <property type="protein sequence ID" value="PSU_v2.g12391.t1"/>
        <property type="gene ID" value="PSU_v2.g12391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12391.t1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41117" checksum="DA87F7267B361DE8" modified="2023-02-22" version="1">MYLRLQNVTHLNNLGPVRFAATYPKYTPKLKNELFPHVAPVSLTYKKTKSDEWTKMSPNGLINGYLQLSKHRLSLLIASTAAGGYMVAPGYMDAKCFVACTVGTMLMSASANACNHLLEAPYDAQMKRTQSRVLVVHRFTPLHALTFAGITSITGATILWAGCNPLTAALGVLNLGLYAGVYTPLKRYHIGCTWAGAVVGAIPPLMGYAALTGSLDPAAFVLATILYSWQFPHFNGLSWNLRGDYSRAGYRVMCVTDEGICRRTTIRHSLALLGLCSIAAPLTHLTSLNFAFSSIPLNAAMIYLSYLFYKNPDAKTSRNLFRFSLLYLPLIMVLMVMSSRGTSNEVNSIAALSTSSLHYLPGSLKPVNSPVELTVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0E2</accession>
    <name>A0A914Y0E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0E2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13673.t1">
        <property type="protein sequence ID" value="PSU_v2.g13673.t1"/>
        <property type="gene ID" value="PSU_v2.g13673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13673.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29320" checksum="A0EDC1C3E84ED489" modified="2023-02-22" version="1">MVSTVNNLYFDQFLRIEPCDVNLWYQNLQNMNILTLDHGREIDLTIKKLRLTGQLTWRYLGFEDAISSLLKHVVECEIEELFLQNQILTENEFLTLTKNVKCLTLYDVKIHGNNGEALKAGDILGFVADNIEEFSFASDHDELITLTKSNTNEIPVLPKLKKLTLVDVKNNLKYNEFFEFVKKYQKIEYCFGFQLSDNHDSTVTQNILKSAILCYFRNAEVVREETYNGFWWYWNFDKATVVEGKVPILCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y185</accession>
    <name>A0A914Y185_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y185"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11596.t1">
        <property type="protein sequence ID" value="PSU_v2.g11596.t1"/>
        <property type="gene ID" value="PSU_v2.g11596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11596.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11359" checksum="770CE673896C287D" modified="2023-02-22" version="1">MKSLLHIAEKHGNPHKMLLQIICHLGGVRLSKIVEIFQAICDAALIPTSIPEQCTVESLSKALVKTINAVLAPMELKIAVTTDYRFPDEQFLTMVIKVLFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y254</accession>
    <name>A0A914Y254_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Programmed cell death protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y254"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13314.t1">
        <property type="protein sequence ID" value="PSU_v2.g13314.t1"/>
        <property type="gene ID" value="PSU_v2.g13314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13314.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14687" checksum="223F4B7278C72904" modified="2023-02-22" version="1">MGDDLDDIRAQRMQQMQNRGGGGNSAGPSDAERKQAVEQQEKMKDTILSQVLAQDAMARLSTLRAAKPERAAQVEGMLINMARSGRISSKMNDEQFRGLLDQISGQTQKKTTTVKFDRRRAALDSDDEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2U7</accession>
    <name>A0A914Y2U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2U7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13562.t1">
        <property type="protein sequence ID" value="PSU_v2.g13562.t1"/>
        <property type="gene ID" value="PSU_v2.g13562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14507">
        <property type="entry name" value="PTP-MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
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        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="182"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="400"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13562.t1"/>
        </source>
    </evidence>
    <sequence length="471" mass="54475" checksum="E0CF5D172C24E314" modified="2023-02-22" version="1">MNSTFYVNDFQPVQKVVMLPENQNGEESFEMIDVPNQPKLDWLINGEILQQHEPDAIVSTPKGDIHGNAFVTNYRLKFIPHETNLTKDTHEFDFPLGLINAVKKFGFANNLDPRAAHRTIRGDDSYGIKVVCKDLRTLKFLHQKEKHNRRALYECIVANAFPNTSNKPFFAALYKQPFRNEGWKLFDPVKEFKRMDVPNDLWALTELNKEYKFIDTYPKVLVFPKEALDKGEAFLNKVAKFRSSRRIPALSWYDPKTQVSILRSSQPMSGVIMLSSSDDKAYLEMIWKANPKSKELKIFDARPLGNAHANRFRGGGYETWYPHCKLIFLNIHSIHAIRKSLRTFKDICYPKQKSLIFAPKKILEGGEKSSWVSHLQTILDGTHKIVTEICEEKSSCLIHCSDGWDRTSQLTSLTMLLLDPYYRTLDGFALLIEKEWLSFGHKFAIRFGHGINNPKSKELNFRRPLNLIVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2Y2</accession>
    <name>A0A914Y2Y2_9BILA</name>
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        <submittedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2Y2"/>
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        <property type="protein sequence ID" value="PSU_v2.g12134.t1"/>
        <property type="gene ID" value="PSU_v2.g12134"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RIKEN cDNA 6430531B16 gene"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CH_2"/>
    </dbReference>
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        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF9">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12134.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35700" checksum="10F06167C5C9E2A4" modified="2023-02-22" version="1">MSATLPTLTDSGLDDVYQWIGNLPLSKPVRNISKDLSDGVLIAEIVSHYLPRYIAVNNFTHVNSVALKRYNWETLQKMVFKYLNFQLSDEQIRSLSEGAHGIMEAFLLFLKDKIDLAVAEKRFRPSKRRTRSTTSRGSTLSLNQSDSEYEREISTTNLNKTLKNLKIASTPRSQIDMTNGQSKEEQIQKLLSQVQYLERIIDQKDEHIAALTKKVEQTNISNGTKKKQESGYQKDLIDEQSQVFMSQIHYLESVIQQKEEGIVTLSKQVDKLMGMLYPEQEETNETSDIPSPTQHRQSLRNQNIDFSSHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y382</accession>
    <name>A0A914Y382_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y382"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13907.t1">
        <property type="protein sequence ID" value="PSU_v2.g13907.t1"/>
        <property type="gene ID" value="PSU_v2.g13907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13907.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="13974" checksum="BAD3ECEC2A91CB36" modified="2023-02-22" version="1">MFESAEAGPSNIPDEDALGDATDLAQLIHAKCMRSTNYMYHSVIVAGSDTGGSDIVSICSGRSTRSNLSALREKYAKRSHGLWELANNSRTKQHGEKILLLEPSTSKSPNPMTDSGISKMSGSSSILQLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3F8</accession>
    <name>A0A914Y3F8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3F8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14722.t1">
        <property type="protein sequence ID" value="PSU_v2.g14722.t1"/>
        <property type="gene ID" value="PSU_v2.g14722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14722.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17293" checksum="094C82BC031B52BD" modified="2023-02-22" version="1">MALRAKDVGGEFFTPREYQVELFEHSIDKDSIILLPTGTGKTYIAVMLIKHMAPYLGPKKKTAVFIVNKVAVLEQQYIYLNNCTSLNVGKWHDKDVTKQKEKFVQFVQDNDVILTTAQHFLNGLTHALINTGDFALIVMDECHHCLGEKHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Q0</accession>
    <name>A0A914Y3Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Q0"/>
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        <property type="protein sequence ID" value="PSU_v2.g14820.t1"/>
        <property type="gene ID" value="PSU_v2.g14820"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14820.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20212" checksum="84F779E8694288F3" modified="2023-02-22" version="1">MDIYTFKTPRPQHFSLPYPIMKYILKNATPKAWKKLIQTCKYFFPKNPVFPVYDLQADDNGKWHGDDGRINTNNPVAKLWLYNILFAFHSGLSPTTISSLIPKLSNCSLKAVLFTGQNLTWNEFQFLTSSGSIEWFDFCDCTLKYSDGKFVTFDKVLENFKNVESLYVFLKICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y457</accession>
    <name>A0A914Y457_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y457"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13560.t1">
        <property type="protein sequence ID" value="PSU_v2.g13560.t1"/>
        <property type="gene ID" value="PSU_v2.g13560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401:SF6">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036673148" evidence="1">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13560.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27658" checksum="6FEB16CD004AE2F6" modified="2023-02-22" version="1">MYFYAFCLVLLILGGETAKLPEQIAEHSETLLKASQTGKKIRECTCDEQGECIKEMKKQFEGCFDKCWPIVSKEGFKLVKNPEKTKECFQNKRNFVDDMLDCMQNDLNTCVKEKESKEISYVDISKFLEKGEKKLQDQADLLFETVGDEGREVIDIAFKVGHCMRSCFVEKNAGGYCYDKKGCQPLLESEDTGSSVKKCLKEVGWKKQAQDVCKCTVKAGVEEADRWCAVIETVASSKNPVPTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y498</accession>
    <name>A0A914Y498_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y498"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14054.t1">
        <property type="protein sequence ID" value="PSU_v2.g14054.t1"/>
        <property type="gene ID" value="PSU_v2.g14054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14054.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16126" checksum="699B84B848F38656" modified="2023-02-22" version="1">MVVERSAFYHLRKQVAIWIYPALAGTVIFLDWNNTRLWKSGKKINVLDKILGSEQAAYLPKPQQKVLIMGTFTFSYLAKKIFLNDPAHYIFVPALIWFSYCWNEAGIYKRSMMKGHSKMYADRLKSIPSNHHDPWKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y713</accession>
    <name>A0A914Y713_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y713"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13418.t1">
        <property type="protein sequence ID" value="PSU_v2.g13418.t1"/>
        <property type="gene ID" value="PSU_v2.g13418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="9">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13418.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18593" checksum="7AE820A9BDE0B912" modified="2023-02-22" version="1">MAAEKIHFLDVHVMNYAWGRPANQSAVAKLAGGLADPTKTYAELWMGTHVNGPAQIPEKSTSLKEYISSNPQVLAAHENGDIQYLFKVLSVAKALSVQSHPTKDLAKELHAKDPKNYPDDNHKPEMTVALTEFEILCGFRKVEDIAKNFEGMILLHQFYHYIVVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8N9</accession>
    <name>A0A914Y8N9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8N9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15116.t1">
        <property type="protein sequence ID" value="PSU_v2.g15116.t1"/>
        <property type="gene ID" value="PSU_v2.g15116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15116.t1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43117" checksum="85D6BD01F552A4EF" modified="2023-02-22" version="1">MDSSYRRSRSQSRFPPIDEHPGGYPTGQPLDNSHRSKSLDNRRDFVPEDDYDPYRSIERNSTFHASLGGQRQPRRDPYDNQNQRNGGGDFFNETITIPSAHTKSNSKFDSRHEGADDDWTSYDRQVRYHTERTAYPNRAPPPSQLYYDNYGYRNQIQAPPQELSPRSAISRYPESELYERRYDRNYQQQQNQDYRNENDARMRGHGHFSAEGYGDEEEYLTKQSNIGGINRGIMNESAGAAAAVTSGRGAVGAAAGGGGGGHYRYHHESHSHGGGGGASGGKAHYGQTNGYSQNAFSQHREKRSGGGFFSGGRSKKGLQAGPPGMEPRERVYHRIHCCCFSFKWPPFAYEECEPPRPMYLTQPPKGSPMPSRHTLPPPPPPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y946</accession>
    <name>A0A914Y946_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprotein allergen nematode domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y946"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14080.t1">
        <property type="protein sequence ID" value="PSU_v2.g14080.t1"/>
        <property type="gene ID" value="PSU_v2.g14080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.30">
        <property type="entry name" value="Nematode polyprotein allergen ABA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032487">
        <property type="entry name" value="ABA-1_nematode"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038289">
        <property type="entry name" value="DVA-1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16469">
        <property type="entry name" value="NPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="1">
        <location>
            <begin position="138"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14080.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="32184" checksum="28532A7896C25E40" modified="2023-02-22" version="1">MFKSRCIDFFGSETVEFIHGLHDEKSSVSIFDNFLIENPNDTFALRIKAEILFRAYRFEEALELYDSILLIEEDPLSITIIEKKKADALAFLERFDEAILIYEKYLETDENSEISDKLINALIRRADQSYDKATETIFKKHFEGNLEWLNEKQKRIIRRLKVEGKKAPEIFLKINEFFDQLEDEEAKHDAIHSIEHGCIRILYSVFGILKAEELINLRDNSTQGFQIKYKEFFDNLSEEGQKRIANAYMSSCQKVLTFDSEESIPPNNDYIFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y990</accession>
    <name>A0A914Y990_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y990"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16763.t1">
        <property type="protein sequence ID" value="PSU_v2.g16763.t1"/>
        <property type="gene ID" value="PSU_v2.g16763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05347">
        <property type="entry name" value="Ga5DH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000383">
        <property type="entry name" value="SDR family oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16763.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27020" checksum="6E6D0FE95BA4E143" modified="2023-02-22" version="1">MDFFSLKGKTAIVTGGNSGLGQAFAMALAKAGANIFIPSFVKDNGETKEMIEKQGVEVDFMQVDITAEGAPQKIIAACCERFGTVDILVNNAGICKLNKVLDFGRADWDPMIDVNLTAAFELSYEAAKIMIPQKSGKIINICSLFSYLGGQWSPAYSATKHALAGFTKAYCDELGQYNIQVNGIAPGYYATDITLATRSNPETNQRVLDHIPANRWGDTQDLMGAAVFLASPASNYVNGHLLVVDGGYLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9P3</accession>
    <name>A0A914Y9P3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TauD/TfdA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9P3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16.t1">
        <property type="protein sequence ID" value="PSU_v2.g16.t1"/>
        <property type="gene ID" value="PSU_v2.g16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14346" checksum="D5C36F01DA4242D6" modified="2023-02-22" version="1">MLIGLIQQTHFGKIFEVTTKVEASNMAYAHGGELPYHTDFPSLSQPPELQMLYMYQKAPNNGGLSMFVDGFYIAHLMRQKYSKAFKILTETPIEFIEEGYDIHERDGKDFKFTFDMASKHRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA81</accession>
    <name>A0A914YA81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA81"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16338.t1">
        <property type="protein sequence ID" value="PSU_v2.g16338.t1"/>
        <property type="gene ID" value="PSU_v2.g16338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037226167" evidence="5">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16338.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15378" checksum="0CC6303C70C15CB4" modified="2023-02-22" version="1">MKLLIIFALFGTAVAIGFGLGRTQSAGVKGQLVCDGKPATGVKVKLYDDDRGIDTDDLMASGKTDGSGHFDLQGHTHEFTTIDPKINIYHDCNDGLTPCQRKVTIFIPDKYVSSGEHPKEIYDAGVTELAGKFKGEERDCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAE3</accession>
    <name>A0A914YAE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g164.t1">
        <property type="protein sequence ID" value="PSU_v2.g164.t1"/>
        <property type="gene ID" value="PSU_v2.g164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g164.t1"/>
        </source>
    </evidence>
    <sequence length="519" mass="57495" checksum="9CA086AA10C7C6F1" modified="2023-02-22" version="1">MATDRFKEADLQFAIPKVPQSANRNQVVRVGPKSLSTKNEVRKVVPEEKYIENISAIIQRDYFPDVKKLKIQKEYLEAMAVGDEAKIRELQLKYGIKNAPNATPALSDFETPSTSYTGAFSTPTTNNGFSYCNPEGDNDRIEPPKKKRVKALDKFSLQSYLDNFTSEDNASFEELAALMNERERKKNSWMYAAERKHNEDYRNQLKPITAAADEQLLAIKNAEVKPIAIDGWSYKARNDLIFMPVDEAPLTKAELVERIQMNEIVINKEATRLKKDDTMNAKPVTMARAALHQAANYIGRVDVTGKELGVVDAETLGCIATPVPEPGVDDTPLMTWGEIDGTPFRLDGDDDPILMNAPVFKIPEVPIRDKIANSMNDTIGKRYTNKRKTALNAAAQAHPKTPKFGTKRSQLAMGLSPAAKNLLHHRLGIKVGSSNNSRTGTPSIRSGNSSVRSTTSSSFTGTPDLRSFVRTSKQQRISKYNSTPDIHKGAAAAAVSNLLDLELPKLSSNNIRPKAVDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAJ4</accession>
    <name>A0A914YAJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14528.t1">
        <property type="protein sequence ID" value="PSU_v2.g14528.t1"/>
        <property type="gene ID" value="PSU_v2.g14528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022603">
        <property type="term" value="P:regulation of anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000026">
        <property type="term" value="P:regulation of multicellular organismal development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000013">
        <property type="entry name" value="Putative zinc finger E-box-binding homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF27">
        <property type="entry name" value="ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14528.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26851" checksum="62543883D796AFCF" modified="2023-02-22" version="1">MSHLQKEKHNTSESSRDVSPINEKEEEVEEEALDLSVRPASNSSGHGSIQESEKDDETEAFWETSKFIGFFQRECANLKEVLQRKSENANSETLSQMSPLDTATDSAHSDAGQSEASGSIWPVTPNIYSMLGVKSIAELQRALENNELENPASESSTSKKVRQNWRAHKLDEDGVYACDQCEKTFGKQSSLARHKYEHSELHTGDKPFQCNKCLKRFSHSGSYSQHLNHRYAYCKPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBA9</accession>
    <name>A0A914YBA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17497.t1">
        <property type="protein sequence ID" value="PSU_v2.g17497.t1"/>
        <property type="gene ID" value="PSU_v2.g17497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037846705" evidence="1">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17497.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12988" checksum="F0BBE5558FB66673" modified="2023-02-22" version="1">MKFGCGVLIFLFVFICLQLQHSEAVKCPFNRHNLNETKECSACAVVVCGFDGNVTHGCSSDDLFKKCPKKYDNDIDFIKRRSIKFYKNDTFEYFSGCSGAVNGTKCMQDEVCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBE0</accession>
    <name>A0A914YBE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MutL C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBE0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16595.t1">
        <property type="protein sequence ID" value="PSU_v2.g16595.t1"/>
        <property type="gene ID" value="PSU_v2.g16595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="2">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16595.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="28089" checksum="2047830EA71181FE" modified="2023-02-22" version="1">MQNASQEMDESLYDDGDKNDDISILESSSTDNIFVNDENDKRIPKSSNEDRSEADERQRDTVAEEEEEPINDENESIVVKQQKPIKRNPVNQLLENPPEWYYGYLSREDPESSEAQTVRICHEEYRSPTEIGHGNFLEYIKTLNVEAAALSSSQLHDLSFEEENSQKIANEEDTKVVIKKEDFSRMKVLWQFNKSFIFCNLDKHVFIVDQHAADEKGNFENYVKNAKLKRQILIKFVLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDN2</accession>
    <name>A0A914YDN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDN2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1686.t1">
        <property type="protein sequence ID" value="PSU_v2.g1686.t1"/>
        <property type="gene ID" value="PSU_v2.g1686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002244">
        <property type="entry name" value="CBN-TWK-30 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002077">
        <property type="entry name" value="TWiK family of potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF113">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="365"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="461"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1686.t1"/>
        </source>
    </evidence>
    <sequence length="596" mass="69197" checksum="75CDFC081B558E5A" modified="2023-02-22" version="1">MLEGEPMKEKKKIQLAQIREDSDDYMEQVFDLVQRNKEMMKEMDEKELTKMIMQQTQDKFGKYVDSIFDAHRSFRHGFEDDSPTWDFLNAIVFTSTTLTSIGFGFVCPITFLGRLFLILYCLIGIPLCLVTVANIAKFISESVFHLHYKLWKAWVKFKNRNKESTSTGSNGVGSEEEDKMLFNDSEDEQEILDRVKLIRFPPFVVFMFAIVYGFVAAGLIAQWEEWTYLEALYFTFIAILTVGFGDFRPEPHNMITILVITIGGVTLTTMCMDVVGRMYLKEIHYLGRKLQTNNPFYLIRQAKARRRRAAMASLLAQLARGMIFAHRNYSELARKRSSSKRKRKKRESHILPDGKFMFARLPPDPPRECQVVSTSAYSVRLGWAPAFSTDSEVTYNIRYRLKYVKSKDDSKIRELKGISGNTVEIMACDSCSLYEFRITAVSKFGESKPVYLVQYTEPQLSPQHILATKLNSNTIELTWDPPYKRTNDVKNYMVYYTENPTARLSDWQKVPVYGKRVVFPELKYDWFYLFCANACFKDGQRSPLSRALFVKTDKLEFNSLYVGHSRTIEVMEAISEHTENTEATPLLKRDYQSFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDZ9</accession>
    <name>A0A914YDZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17658.t1">
        <property type="protein sequence ID" value="PSU_v2.g17658.t1"/>
        <property type="gene ID" value="PSU_v2.g17658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF423">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17658.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="10854" checksum="BDDD43F5411252BD" modified="2023-02-22" version="1">MGDEGPEGEPGQPGDLGADGVVGAPGEDGIGFNKGPPGPKGEPGVAGDAGEEGLPGERGDDAAPGPAGEPGPVGHIGGPGKDGHPGPRGKAGGPGMHITAINLLHTHLIIFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEN1</accession>
    <name>A0A914YEN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1585.t1">
        <property type="protein sequence ID" value="PSU_v2.g1585.t1"/>
        <property type="gene ID" value="PSU_v2.g1585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1585.t1"/>
        </source>
    </evidence>
    <sequence length="682" mass="77976" checksum="02D8D2DB32AAB392" modified="2023-02-22" version="1">MDRLLSPLIPSDMLTEPTLPTLPTPPIGSPFISQVNQQFYVDHRNLEPLKAFVQSNQQCSAIFNQLTGSKHEIPGRCEELKQLNKNIEERVIRGALMTPEVQQIHDYAQQLQNYVFGLESKIGKLKLQLMSRIETSQSLMGRAMQILVAEKLVDWLIKQKEISCGPRAAIKKHYDLLDVMDHEFEECGQQISILLNIVSQLHSIIDNTTPDLFGRLHKSRNDLIQNTRQFVWQSLVIAVQPPVVLVKCRGSDSHRSTRFPCKTELRLLGGEALGVRQQCSKVRVEIINEEMARKIQQDPCQSATIEQSFHLIYNEAKFQVDPPTGLQLSPVCRASFDRIRLVENAVATKRSATENGFEEKKGTRRSKVSSLRYYLAYQIELTGHHYIEVSGYKLSLPVAALVHSSLEAEASLFWNRSFAEGVRSSFIFLGISFHLFFLKTGILSVVPDNVSWERVRNALNLKFMSLIQEPQDVKELTVDPPEPRELSEENLEHLARRLCVVDGMVHKRNFFNKTVAHKENKVQDGSPVACVFYEWFYKCASMVNKYMQEQWNDGLITGFCSKEDSERNLRSVVQPTMLIRFSDLVIGYLKISCKLPDHRVVHYETEAEKMPIGTSIADAIRCNPTFAFIQNIFPNRRVSLLWQDRERVEETRGENWNQAMPPGYFDTVYSLESKPVAAIDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFT8</accession>
    <name>A0A914YFT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16215.t1">
        <property type="protein sequence ID" value="PSU_v2.g16215.t1"/>
        <property type="gene ID" value="PSU_v2.g16215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0469">Meiosis</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16215.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30597" checksum="E35505CDE4251CE9" modified="2023-02-22" version="1">MDWVHCNHCLRLPGAQNTFFLTSCSHILCQKCSRQDELLQTQTQHTCVVCNNKIKIVEINRNLRPDMMLYFKNPKELATQYLQNIKSVIDFQDKQRAHFSKAQQDKYNKAIKFAKECQVSLKKKSACEKQIIQEKNNLADENERNKVMIKELQEKMAEQSREIERLCKNNTPRSASQKRYPSLNGNTPIRPLSFSDVPHSTPIDGALGPNHKRPNGKSSTPLQDLFGRLDDSVVASSDVGITTPFMLGIQKKPSGGYPEKSPNFGALFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGA2</accession>
    <name>A0A914YGA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18345.t1">
        <property type="protein sequence ID" value="PSU_v2.g18345.t1"/>
        <property type="gene ID" value="PSU_v2.g18345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037885907" evidence="2">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18345.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15265" checksum="DEF5FBAA060B5D1D" modified="2023-02-22" version="1">MHHFCIRAIIYALFISFVLSAQSSNPSDKNNAPSLPVVEGSGAVPSKGNKNVVAADIDWEASGVGPDDEDGDVIEGSGGTAPSDSEVEGSGIPLSREHPPIRTTTLSSTTKTSSSPSSVTSRPPSTTSPIAIATTVITITTEDTKRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGJ8</accession>
    <name>A0A914YGJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18440.t1">
        <property type="protein sequence ID" value="PSU_v2.g18440.t1"/>
        <property type="gene ID" value="PSU_v2.g18440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003834">
        <property type="term" value="F:beta-carotene 15,15'-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18440.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10651" checksum="F4F14B87FE8A5640" modified="2023-02-22" version="1">MVIPIEIELGNFKAGDDLLDGFEFPRYNLNYNLKPYKFIYGSILLGLPESLCGLIKVNADTGEIVTWKRDHKKQIATEPVFIPHPEAKDEDDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGR9</accession>
    <name>A0A914YGR9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YGR9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18650.t1">
        <property type="protein sequence ID" value="PSU_v2.g18650.t1"/>
        <property type="gene ID" value="PSU_v2.g18650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="5">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18650.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16773" checksum="A973875EAF56FD7E" modified="2023-02-22" version="1">MIDKLIQAVRDESWPEATQLLYNHWSERCPKLYTTPDEEPWDNKVDEDSINKELLAPLAAMYILDNQEISKGEPVSLKPLTEKVGIKETLRKPGQLCGRMFRHGDPTYTCKECALDDTCVLCLECFKQSPHAKHKYKVIYFLTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH04</accession>
    <name>A0A914YH04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH04"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19598.t1">
        <property type="protein sequence ID" value="PSU_v2.g19598.t1"/>
        <property type="gene ID" value="PSU_v2.g19598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04014">
        <property type="entry name" value="C2_PKC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000056">
        <property type="entry name" value="Protein kinase C epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19598.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15439" checksum="8A984CE3AF7F81D3" modified="2023-02-22" version="1">MTVFNGTAKIRVVEARDLRPTEWSKRFNSSDTETAQQLDAYVNVDLDEYHVGQTVTKPKTSTPVWNEDYQTDVHNGKVLGFTIFHDCALPPDDFVANSKFGFDELKLKTVNDIWVDLEPHGRLHLIIELKGSFAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH20</accession>
    <name>A0A914YH20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19611.t1">
        <property type="protein sequence ID" value="PSU_v2.g19611.t1"/>
        <property type="gene ID" value="PSU_v2.g19611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19611.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18515" checksum="276628B771A283E4" modified="2023-02-22" version="1">MIEVLFHVRKEKFVSYPSIVEELDLIEEEDQVCHLVHIISEDDKPLDPETGLNIFKYDPNFEETEKQYDEIRREIIGDADDSDDEEGEEDGAQPAAGEDGDEAEDTAKPLVSMKIVDMTEAEQAAFRRKVYLTIQSSLDFQEAAHKLIKNIYKPGIEVSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIF0</accession>
    <name>A0A914YIF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc-finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIF0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19279.t1">
        <property type="protein sequence ID" value="PSU_v2.g19279.t1"/>
        <property type="gene ID" value="PSU_v2.g19279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative zinc-finger" evidence="2">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19279.t1"/>
        </source>
    </evidence>
    <sequence length="963" mass="108380" checksum="3EEAAC9AE51096B8" modified="2023-02-22" version="1">MSEREEGELDSGEEERGSSPSILPKATKTSQRLDVSSSASLEKKSCSLIEEDMYSVPERDNDRKEPNANYRKSRRAFKPPANAFNQISNSKQKFVSRRVNEGRFHSPPPSSDKNTFDEPPVHQLFASTNSNECSPPKPSDSWRQDPMPLNAFPTVSPRRPLLPNPFVSQTAPQYPSQRPTIFNISHPRASSFAPPPYHPSNPTTMPTFFGVSHPLPDVQYSAFRENPGPLAARLSIDMEISPVNSPLMTDNCVMIVDEPLEESDDSQPPTVARPEPIRVPCNIITDTVDPLVPYGTEPGRYSIPQNDTFQTQAAILSTTNQAVEQPSAVNQSEERLPSEIPPQKLQKRFSKDFLQHMQSVLLDNLYELSSSSSSSSEFEEEANEIDGLRRKLIHHNKEMHDELDKRERLVKEMESCQLMINHHYERMNAIMRSMGDTSRQSIRHARKSLSKTRNEGRKRRKKLCDNFESRVGAILDELSAMNEEIKTPSQELTTSEKPDETSGLAEVLGNLLEDSGVEFIHTLDESSMAVIETPKAKGKRTVIDKGFEDEYLKMMFKARFGIKPLPHVVVVEPVKHPAKKPSKKKNSTGSANVNLEMEEALRRKLLEQMKKKEQLFPSLHEKRKDVQNEKTSSENLKDKSGVVEVEVVNPSPIVQTLRSAADVDTVSSLKSSDVATELAWINNDVDTVPPLKKVADMATVHALKSLVDAASVPESVREKPKIVPTMKDILELKKELKIALNKRRKSVNKRDPKVAASAAKISPVKQNSEATNSSKTSTPVKIITSVPNAVEKENAGNIGINSLKRPAPPPERIHSSKKPRSLPEEKSKSLDEFERRSQELLFDSPRVAVRNFILSPEYPVKESIERLRHKNDANVELCYFELFGICNDDECPYQHSRDFTLNDEQILEEILGYIPERSSRPDSSIKQQARKLLESNSLEEIIETLRKETSHLDLIKLAIESSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKB0</accession>
    <name>A0A914YKB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17743.t1">
        <property type="protein sequence ID" value="PSU_v2.g17743.t1"/>
        <property type="gene ID" value="PSU_v2.g17743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17743.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11728" checksum="52320E2A8E1DB20F" modified="2023-02-22" version="1">MDAELSKYLINSNKNVCIVLNKSDEMIDNLKKQQNFFGNDDYVRKRLEGAQREFVKVGIEPINLPCFSVSTFVLTGFLDNTYNTEEQAFLNYLRHVLCRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL60</accession>
    <name>A0A914YL60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YL60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18057.t1">
        <property type="protein sequence ID" value="PSU_v2.g18057.t1"/>
        <property type="gene ID" value="PSU_v2.g18057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF102">
        <property type="entry name" value="CYTOCHROME P450 FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18057.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10753" checksum="FD693B2653EE4A16" modified="2023-02-22" version="1">MIKEIFIKQFSSFINREFSTFTQGYPLGESLLQVDKEGPHGYGWKEIRSIASPTFTTGKMKMMHDTIHERVITFTKVLEEKSKENDCINIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMU0</accession>
    <name>A0A914YMU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alanine aminotransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20911.t1">
        <property type="protein sequence ID" value="PSU_v2.g20911.t1"/>
        <property type="gene ID" value="PSU_v2.g20911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051926">
        <property type="entry name" value="Ala_Aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43488">
        <property type="entry name" value="GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43488:SF2">
        <property type="entry name" value="GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20911.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19559" checksum="E77506D006DF016E" modified="2023-02-22" version="1">MPFDGPAPMSTLSPKPLAIRERLSEVRYEIRGELARRARELEAQGRKLIKLNIGNPGNFGFRAPEHLQRAIADDMGRTDPYTHQQGLPVAREAIAAYYARRGAPDAHPDRVPGALAGLPAVVGLDHPQRWPPGVLPLRRRERLPAGPERDRDAGVLAHPCHRADQPEQPQRRQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN00</accession>
    <name>A0A914YN00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YN00"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2266.t1">
        <property type="protein sequence ID" value="PSU_v2.g2266.t1"/>
        <property type="gene ID" value="PSU_v2.g2266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2266.t1"/>
        </source>
    </evidence>
    <sequence length="556" mass="63565" checksum="979E3570FDF1A0B0" modified="2023-02-22" version="1">MLEEIAEAKEKLDQKWEERYKEYQSIENVAAFNSLADETINVLTECYQFLENNKTKNMDKAQLANMLAEVNSHIDNLQITAHNVIKIREDLTEYINKKVLVIMDMQEALIKKAKEEAEKEEEEKEKEITSDDSSNRYDTPKIPPHPVKPVQPVTKEQYFFPKKISTYDETINAIGIDLGTSRCCMAVSRNNKMETVGLENTGERPLPSFVAFDEEDDKCGVVVVDGFLKGKEKYTVFDVKRFIGKEFHDIVPDRSWPFEVIEENGKVKIKTENINGEVLKTPEEISAVLLKYMKEKAKEFQGKDETKTVLTVPAAFSEKQKQATLEAAKLAGWKTIHLLPEPIAASFAYFNNREIPNNSNILLFDLGGGTLDVCLFKIIDQKIEFISKFGDICLGGRDIDNLLIRHFSTILRFRYNININEKIRRKYQLMLECQSIKQNLTVMKKDTLNVETFDSNINGVIEIERSELEELMTDLLQRMKTAINQTLNNANLAPKEIHKILQVGGGCRMPIVKEMLKNMFPNSEHCVEENPDEVVAVGAAIYAYHLATINDEDKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP30</accession>
    <name>A0A914YP30_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="5">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YP30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21389.t1">
        <property type="protein sequence ID" value="PSU_v2.g21389.t1"/>
        <property type="gene ID" value="PSU_v2.g21389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21389.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16911" checksum="6B0490B1E2CF6A33" modified="2023-02-22" version="1">MDNFQRAERTPLLSTVDEVNNPGGQRSEAVSAARSHRAGTETSDDDTVKFYNEQYGSVSGADFAAVLVESHRAINHGIFPERIPQGSSGSYFVKNLRGEKIGVFKPKNEEPYGNLNPKWVKWLHKIFFPCCFGRSCLVPNQLVLSVYLNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPN7</accession>
    <name>A0A914YPN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3456 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2785.t1">
        <property type="protein sequence ID" value="PSU_v2.g2785.t1"/>
        <property type="gene ID" value="PSU_v2.g2785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042415">
        <property type="entry name" value="CNPY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341">
        <property type="entry name" value="MIR-INTERACTING SAPOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341:SF2">
        <property type="entry name" value="PROTEIN SEELE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037355629" evidence="3">
        <location>
            <begin position="21"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="4">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2785.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22015" checksum="9F4715D88C31B771" modified="2023-02-22" version="1">MKLYKILILFSINFIIAVLSTEETSVKCGACMLVVREFEKAIKAVDPKKMTTVGSFRVDPKGNQKGLVEIPFARSEAHLQDVLEEVCEKSKKYTQTIHPVTGKKTYIHEEIIVEYKRIPGMSNKLHSACIDFVDDNDSEIIKFMQKEAEDTLRDLCHDKLGLCTSVDVSPFPDPTPNDDELDTPSYNDDLGNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPS8</accession>
    <name>A0A914YPS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19367.t1">
        <property type="protein sequence ID" value="PSU_v2.g19367.t1"/>
        <property type="gene ID" value="PSU_v2.g19367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19367.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14088" checksum="619BEC77C1AF9402" modified="2023-02-22" version="1">MINGDEHVEVGFMTGKPFREDTGFAVKNKPKTGDNLVAIESVGNNGLIIIEEGILLPDQINLGITYQKSYTTLPLLEGNRTFKLLAPHILEERVRLVLSNGKIEKFRKKYVKVFDYLEDYVSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQY4</accession>
    <name>A0A914YQY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g319.t1">
        <property type="protein sequence ID" value="PSU_v2.g319.t1"/>
        <property type="gene ID" value="PSU_v2.g319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g319.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19662" checksum="64A9EC04F1C8DD8B" modified="2023-02-22" version="1">MLLINSNLLQYKKTCASIYKARHGACSQTGFGVMCFNYCFEQGEKLAFRCQDTSDATYCRNSGNFDTFLSKYRKDAYKAKAYIHQMISRCYATAICNLQSGILNSTLIDGDTKFPDDSTPKAPPALIRGAQRTLSSLKAGKTLLPRVTKLPLAVAVSLYLYYLPSETTKIIYNDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR21</accession>
    <name>A0A914YR21_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="1">EF-Ts</shortName>
            <shortName evidence="1">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g323.t1">
        <property type="protein sequence ID" value="PSU_v2.g323.t1"/>
        <property type="gene ID" value="PSU_v2.g323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g323.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15809" checksum="1891632D556D14F4" modified="2023-02-22" version="1">MECKKALTEANGDINAAAEAMRKSGAAKADKKADRVAAEGRXXXXXXXXXXXXXXXXXXXXXXXXRPSGPGPGRRQGRAGRSQLGNRLRRQRRQLQDLRRRRRHCRPGIGRHRRRSREGCQAGRRPYRRGSPRHRRADPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS90</accession>
    <name>A0A914YS90_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YS90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3039.t1">
        <property type="protein sequence ID" value="PSU_v2.g3039.t1"/>
        <property type="gene ID" value="PSU_v2.g3039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3039.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11009" checksum="1D6D61923248A521" modified="2023-02-22" version="1">MGLKRYVNTYGATETMMTAVSYPEDKNIVKPMHVMPHMEIGIINKNGKFVNRGEKGEIIVRGYSVMHGYWNDEEKTQQVLDKDRWYHTGWGTNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS97</accession>
    <name>A0A914YS97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YS97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20270.t1">
        <property type="protein sequence ID" value="PSU_v2.g20270.t1"/>
        <property type="gene ID" value="PSU_v2.g20270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20270.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8980" checksum="AC6968566B550938" modified="2023-02-22" version="1">MCCEVLSHPADVIVTQLYESPTTTFKSVANSLDFKGLWVGTGARMVLIGVITGIQLFLIDTVRSSFNLEKGKPLERKICQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT95</accession>
    <name>A0A914YT95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT95"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3383.t1">
        <property type="protein sequence ID" value="PSU_v2.g3383.t1"/>
        <property type="gene ID" value="PSU_v2.g3383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3383.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20676" checksum="378314E17A474760" modified="2023-02-22" version="1">MGDGKGDNRQGFSGKHVRGDNRQSGSGSEKSLTSISKSRYPTVRTRVVVKTPPQSANERDVRRRLRKLKYDFNSANEDLVKLDFAAKLEKARKEVGNIMGLMSDIMECKGDIPKQLKKDLAYHQEKIGSYVTRYQDILDLKQSIKDKSFKLREELRLIFNSYKGVTQEFDVDLDEDFFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTC8</accession>
    <name>A0A914YTC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3417.t1">
        <property type="protein sequence ID" value="PSU_v2.g3417.t1"/>
        <property type="gene ID" value="PSU_v2.g3417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3417.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26700" checksum="5FD9AC42DD964E93" modified="2023-02-22" version="1">MFIAGHKAIYDAGGILSATSREELIENLQAEVEANQIIIRENVEKIDNGLDNFEKPQGGSTSKEEANLGKIEIADLKSLHLKDVRQFHAKRATLFSMSKHTAADLAAAPEPEEDNEAGLQEYVQTYAADPATMRPCFSYSLVSALAWTGCHEAHCRKDLDEEEEEVKEGDEVDVDDGDVEKEGGRPPMNLVSAAAINYRCKLVGSYLYCIYPETRVLFLSVSSPLFANVIFRCFLFTLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU02</accession>
    <name>A0A914YU02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3139.t1">
        <property type="protein sequence ID" value="PSU_v2.g3139.t1"/>
        <property type="gene ID" value="PSU_v2.g3139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040264">
        <property type="entry name" value="T15H9.4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31327">
        <property type="entry name" value="SPERM MEIOSIS PDZ DOMAIN CONTAINING PROTEINS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="201"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3139.t1"/>
        </source>
    </evidence>
    <sequence length="540" mass="61141" checksum="B60918D7555238A2" modified="2023-02-22" version="1">MKREGDGGDEGAADDRPIFRATNDRKFDDSPMKAADDPIRREFNEIVSAANIANGGGENYIPQDMTAKIAAESAESLAPLPSSTERLELDIDLEDDLNLGIKVNDKLFVEGFKKMGLQESKFTIGDQITAVNARNLRSAAHFQKLLQKYGPHVRISVYRPMYTTKAHQFRLNKHGLTAAVIKNSFAEDQFLIAHISYRPSIHLGLSINSYDGCVVVSRVDKDSLAYRRFEIGDIIVDVEGEIVHDKNEFRNYMMDAMDRNSYASVLIQRPFSQKSVSLAKTALGLNQKDPRDPPFPHDAMIIGRKEMQRFKAFETNNNNKRGIRSILNSSPSAHHHLVISDEKPAEIRINSDIPEGKKLTPCPTRAQLHARLRAKLGKKNKKNTTKAEREIIYSSMDANSPDTYAPPILTATATPEIKPKEESLLRRAQDSWKEKRSKMFNSGKKDTDSESSSRRTKSKKKVFEKEQISDRKNSNSDKSVARKDGSDRRKPLNDDGSDKKKKVFGGDDASERRYRNEDGSERQQRRRIDDSGKKRKQRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU08</accession>
    <name>A0A914YU08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YU08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3478.t1">
        <property type="protein sequence ID" value="PSU_v2.g3478.t1"/>
        <property type="gene ID" value="PSU_v2.g3478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3478.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="47952" checksum="AAE037CE7D8B98FE" modified="2023-02-22" version="1">MTGAFIDDNRCDYANVSATNLSADCLHRKSGSMIHEFELHGPHENLKHWFTSSFMLGNIIGGSAISLLADQYGRKPCVIICTLLLGITGCFMQFVKTYQFVLILRFLHGIFFTGSSIAIWVLGYESIPTSLRSYATFTYGTTWVIGYCAIAPIAYFVSNWRIFLTVLSIPCIFYAVVLWIFLPESFHFLVSKNRHREAKAWVNKCNVEKLSFTDDNSRICRPMKNHEGESFYTQVKGLITNTKLIFRVFVFSFLWTTDVLVYFGMSLFSVKLVGNHYFNYIAIGLIEIPAYAFGPVLLDKIGRRLTISTTHIVTAIAFTMAAFVLTHNPIAQLLFWLIAKFAISAAFMGIFVYAAESFPTTERSVCVGTCSVFGKLFGCLAPFIQTTASIWSPLPLVIFGAISGVAGFVTLLLPETKDQQLPDSSDNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUZ4</accession>
    <name>A0A914YUZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUZ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g349.t1">
        <property type="protein sequence ID" value="PSU_v2.g349.t1"/>
        <property type="gene ID" value="PSU_v2.g349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g349.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17849" checksum="20BA81DCC2D402A9" modified="2023-02-22" version="1">MIERKSFDELKEDTVRKKVNVLQSLVELLAQHICPSNSDALLRFDKKKDKQVSSDTKRIEILLAYVSEQFHAAETTKERIDVLAQIAISVDFATFNRYIPQITPYLYKLARFEAHRRLETWTVEPEKHLRIRYIPEHIDLFVQFITRVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV62</accession>
    <name>A0A914YV62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YV62"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4488.t1">
        <property type="protein sequence ID" value="PSU_v2.g4488.t1"/>
        <property type="gene ID" value="PSU_v2.g4488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4488.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29290" checksum="53777D45F4BA4EC1" modified="2023-02-22" version="1">MGQPYSEIQERAAWILAHMLIVSSKYAKEVVNAGGISPFVYLMDSNNSMTKEESLRSLQEMTLFCKKYRDYAIANGMITKIVKIVMFDKTSMNIEHRVAQLINAISMHSDISIDALKELLPAIKKLLSSENDEAINQILQSMFFTMNHDDNDDEISQLFLDYGMAQKLVPFLDSENFKFRAIALPVIANLCSNNPEKIKIFLDLGILQFLPKLLNHKDTRENALILWSRMKSDEELKEILKDYEINETPNTKMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVN6</accession>
    <name>A0A914YVN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVN6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21576.t1">
        <property type="protein sequence ID" value="PSU_v2.g21576.t1"/>
        <property type="gene ID" value="PSU_v2.g21576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21576.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="28552" checksum="7A360525219D320B" modified="2023-02-22" version="1">MTGATGATAMTGAAITGATGGVAGATTAKPFELNSTAPLPTFPTLVISLIATTTPFRPPVTGSTAMPAVAGNGSSIAAGVTGMSTGTTISSSGVAGSGSTLAASVGGGSTVASTGMMPSNTSTGMMPSNTTGMAASTGGTTTMKPATVAGVSNGSSMASGVTGMASGTTMASSGVSASASNTTGNGSAVVGGGGSTPSSSATTTTTGPWPTVMLNSMSPLPMNLPNLPAAATTMASATGNGSSGASAGTTKATMNGTTMASSGSGSTMASAGSGSTMASAGSAAGNGTTMGGAGKLVECLYLQHLEKVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVR2</accession>
    <name>A0A914YVR2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVR2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g467.t1">
        <property type="protein sequence ID" value="PSU_v2.g467.t1"/>
        <property type="gene ID" value="PSU_v2.g467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g467.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31712" checksum="42074B2EB52C6124" modified="2023-02-22" version="1">MSTAGELDHLQEENDNTQQLHEHTDDDSLLQQQQQQYDEDGVVVDEHNKDQQLVDDEYNGQDMIGQVIQGEDGELYLLAAADDDTNNAQHEGIMDMNSVQEVKIMVDSETSQMVYYNGDKEEDGSQEPGSSVSGRALSFMAPKNVYPQGMKGRRNRIFGNFSCPLCAKTYKYEYNLFYHWRKTCRDLDDVFSVNERKNLDVNTLRTAVDDLVRKREHYGHISMGISPQQLFRSSHYDKLVLPVRRNLPCKACGVAIPQDMKMLMNLMVVHSFVICVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW11</accession>
    <name>A0A914YW11_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YW11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4166.t1">
        <property type="protein sequence ID" value="PSU_v2.g4166.t1"/>
        <property type="gene ID" value="PSU_v2.g4166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16949">
        <property type="entry name" value="HATPase_CpxA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000011">
        <property type="entry name" value="Sensor histidine kinase CpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058126">
        <property type="entry name" value="CpxA-like_HATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050398">
        <property type="entry name" value="HssS/ArlS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45528">
        <property type="entry name" value="SENSOR HISTIDINE KINASE CPXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45528:SF1">
        <property type="entry name" value="SENSOR HISTIDINE KINASE CPXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4166.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25840" checksum="181E358F8B16E804" modified="2023-02-22" version="1">MVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWGEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWA1</accession>
    <name>A0A914YWA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWA1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g484.t1">
        <property type="protein sequence ID" value="PSU_v2.g484.t1"/>
        <property type="gene ID" value="PSU_v2.g484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g484.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33256" checksum="363969A59924F951" modified="2023-02-22" version="1">MSWECTRRPRKMGGRNPVPVPFARNRSSRQAPYVYCNLHAALQQGSRRHRSARPAARAGSCVHRSDLLRRQRDCRPPRHGHTGRRHHRYGAALAADADSDRHPDLAHRLGVAAAWRRPRARDRPVVPPGTVAGAGAGADHVHLPHRGAAAAAGIRHRAGHRAGGHRVPACGALGRTCADPVFLHALPQRGHALDAADHAARLRWPAGAGTDRLCAGQRQARLPGNGRRRPGHRLGGDDVAAGDRLRHLPVVHQALCPPAAVLALRRTALEGDLGAAAHWPADRHHRADGRRPVHRHRAADRPSRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWA6</accession>
    <name>A0A914YWA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWA6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2364.t1">
        <property type="protein sequence ID" value="PSU_v2.g2364.t1"/>
        <property type="gene ID" value="PSU_v2.g2364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2364.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15987" checksum="B9C6B07A85EBF1F3" modified="2023-02-22" version="1">MTSYQATSVKEQKDICDGNHQMMHDIKVGAKDLKHGIQDGMHGIKEGVRDAVTKAADIVSGHRHSTSFDNDNDYLRENSPVVLTSEDKRNAQLLRQPPYNIHLQNKQNTTCTSAVGQEMASHDRDYYKTGRSEIHFTPSQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWE6</accession>
    <name>A0A914YWE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4430.t1">
        <property type="protein sequence ID" value="PSU_v2.g4430.t1"/>
        <property type="gene ID" value="PSU_v2.g4430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004510">
        <property type="term" value="F:tryptophan 5-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF16">
        <property type="entry name" value="TRYPTOPHAN 5-HYDROXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="9">
        <location>
            <begin position="129"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4430.t1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51855" checksum="7C1281B429A13F59" modified="2023-02-22" version="1">MALKNILPNIGTWKVAPLLFFGFDETIGLSSQQTIDETDEDGVKTISVIVRTINVNNAFRRILGAIPENAKIKHVESRDPKSKAKNEIEVFLELEIEDETVPIVEKICNAGFTAIELSRTYTPKGALEVSDPGSADALSGAVWFPKSIYDLDICCRRVIMYGAGLDADHPGFKDDEYRKRRMMFADIALNYKQGDPIPRVEYTAKETATWKIIYRKLRELHQKHACAEYLENFELLEQHCGYSDSNVPQLEDISNFLKSNYIFFLTGITKYVFAVKTGFRLRPVAGYLSARDFLAGLAFRVFNCTQYVRHHADPFYTPEPDTVHELMGHMALFADPDFAQFSQEIGLASLGTSDEDLSKLATLYFFSIEFGLCCVGHDRITNKPKYKIYGAGLLSSAGELQHAIGEKSEIIRFDPDRVVQQECLITTFQNAYFYTKNFDEAQQKLRYVFWKMCLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY15</accession>
    <name>A0A914YY15_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L28</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YY15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4535.t1">
        <property type="protein sequence ID" value="PSU_v2.g4535.t1"/>
        <property type="gene ID" value="PSU_v2.g4535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4535.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15729" checksum="8B420EA44AF90ACF" modified="2023-02-22" version="1">MVYKNSSKDLVWQVIRNNHAYIRKQRGINKKFSTEKFNLRGINSPRFNGFTNSNGIDVSVNADKQLVVSTKNQGKANFPAKSTTTHNVRATRRAIKTIGNTAKSTRTYLQKAAQLRTSQLLRSLKPSKPRGAHTAAAKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYB7</accession>
    <name>A0A914YYB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arrestin C-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5495.t1">
        <property type="protein sequence ID" value="PSU_v2.g5495.t1"/>
        <property type="gene ID" value="PSU_v2.g5495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="171"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5495.t1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47378" checksum="F19CA2F295F5387A" modified="2023-02-22" version="1">MSSSTNEISIILDNPSGIYAPGSLLTGSVIVILSKPKKSRRITIHAYGHAKTNFTKTHYHDSKNEQYHYSCKKSYLDHCIPVWKPSNGIEKEELQPGQHSFRFSIGIPWNCLPNFEGRFGHIRYNIKAEMHLSWSFNLTTEKRFAVMSIMEPTIYNQPVKGFISQTNTFSSTKLVKAEITLPKRIYACGEEITVAIVIDNHSGTSIESIETGIQSEACYAGETSFSVCSKRKTEHECFHSFCKTESVHIPDGGRDLYRRTFTISKQLPTISDCPIIIVKHFVYVKINKKGIFSSTVMQTIPIILTTASLEPLQLPPKLAITIPPSAPRRDFVEKEEAIVNSIVGISLSSSIHNISSSNSNHHLNPSTSSSSNFRPSSVPNDFALMETYGAPPAYNEIDTILSPTSNPPPNPSAPPEYDETFVQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYD4</accession>
    <name>A0A914YYD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g5509.t1">
        <property type="protein sequence ID" value="PSU_v2.g5509.t1"/>
        <property type="gene ID" value="PSU_v2.g5509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032224">
        <property type="term" value="P:positive regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000061">
        <property type="entry name" value="Sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000030">
        <property type="entry name" value="sodium leak channel non-selective protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF1">
        <property type="entry name" value="SODIUM LEAK CHANNEL NALCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="856"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="942"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="972"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1166"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="119"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="607"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="945"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5509.t1"/>
        </source>
    </evidence>
    <sequence length="1516" mass="175876" checksum="22C51DC0FAA79C1C" modified="2023-02-22" version="1">MGVQLFGRLEYHCVLPETDPNNVTILDLAIPDTMCSKEGLGGYQCPGNTNVFIAVITETFAEIRVQFSEMWQKREVVDDDGFQQKLEKTDNGWKLITVDSELQNSTTPSMLHQIVRSTSFTTTMMIIVLLNAMFNASFVYYHDESDIVRRKFYYYTEIVFTFVFIVETIVKIIALSWGTYIRRGQHKIELILCLGSTLNVIPFLYATNVFTYFQVFRLIRLIKASPMLEDFVYKIFGPGKKLGSLVLFTMLILIITSAVSLQLFCFVPHLHMFRTFPQAFMCMFQIITEEGWTEIVVEILRATNYSKFIVSLVAAYFVGYHLLVTLIVLSLFVAVILDNLEMDEELKKVKQLKAREETTCMRTTLPWRLRIFEKFPTRPQMVTLRKINNDFPVPKVRDSFTRQFADTSSENIFEINNDSGPRKRILRLRQKAKNDDRHLYVRQAGQLSSRSCLRELIDNSNKNRILLFDSNQFIAQKSRSRRDNATHAKPRNLNAKIMYEHLKENGDLRLTDSAPKNNLKEGEIDIKALQQKRAQAEFTRNRKEEEMRENHPFFDRPLFTIGRDSNFRRLCQGIVYAKYTLDKVDPLTGKSIQIKYKQLYSAIGMMPYLDWTMVLITAFSCCSMLLESPWPTTGENLVFNNPYLQICEYIFVFAMTLELLFKVAANGLFFTTHAVVRDIGGVMTIFIYITSVWYLIWMPKHVEINSFAQILMIFRAMRPLRIYTLVPQIRRVVVELCKGFKEILLVTILLILLVFTFASFGVQIVGGKLAACNDYSIKSKENCTGVFEQPLLFTRMDVYGKNTPEMHPKILVQRVWANPQNFNFDHVGNAMLALFETLSYKGWNVMRDLLWMRQGAWSVIFLHVYVFMGCMIGLTLFVGVIVANYMENRGTALLTVDQRRWHDLKARLRMAQPLHIPPKPSESAKIRNYLYELTMSKSFKQFYSVLVVIISGTLVIPWNVDEERAQGDVLFYATLMAACCNILFTVEVVLKIIAFTFHGFWQSKRNRIDLFITILGIAWIFLHFIMDKSAGLVVANTPLRRFTYTFGYTIVTSRFFTITGRKSTLKMLMTTVLMSMLRSFFIISAMFLLVLFYAYTGVILFAMVKYGHTISKHVNFRTSKEALVVLFRCVTGEDWNDIMHAIGAVNPPFCFWREGMNYWETDCGNYYGAVIYFCSFYLIITYIVLNVLVAIIMENFSLFYSSEEDALLSYADIRNFQLVWNMVDTSQKGYIPVCRVKFLLRLLKGRLEVDPTKDKLLFKHMCYEMERLHNSEDVSFHDILSMLSYRSVDIRKSLQLEELLQREELEYIIEEEKQMTEKDLIQQLRNNQLASGTISNPRTSITDVMGLQFTETSITNPLILNRSDQHDIKADIINEERSGTKKSKNRRSSIPDIMGEAKKLMWGTRIKTIPAQSSTPDRPAVNPKDILHDKALFAKRTDKRGTMKQFQMATCDLPDLDEFAEEEEELLANERRLSLDNCNVYREHLSSPGATMLRSIYSESTTNEIQHWWEEIFVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ58</accession>
    <name>A0A914YZ58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5236.t1">
        <property type="protein sequence ID" value="PSU_v2.g5236.t1"/>
        <property type="gene ID" value="PSU_v2.g5236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5236.t1"/>
        </source>
    </evidence>
    <sequence length="426" mass="49443" checksum="016A3CE5C6766398" modified="2023-02-22" version="1">MPSPSLIKDVLKDICKQLSYDDGLDEALKFALSGVEPMNAFMELLTTVKSVEFKHYGVKAVFNWATYYLNFEGDLYSKVICSKILSYTPELTIFVDDIESRHMEFLHDWPNNDRLKKVCVEYAGHNTNFLEPVMSRVLNMPIKHLVADASSLIPFISTIDDREYDNVELRFENGYFDRLETMLTSFRFHSKNVTLSFSGEYTWYEILYVVTKVVKENSSGAVSTLVENLTLNFNGDIDVPALPELQLTDFFEDISKCFPNLKNVKFCIDFTFNAEGFLTEEDASIELYVSTYTEVIKQVSKAKTEYNLFVEWIREDHVVDISPTNTHFVSLCEALTNDLGFKKIDDKESCWEVEKKITDKKSFKMTVTLIQPSFQDFDMHEEILYDAGILMGDEYPSDYDPNEEYDYEYEDYEGGDYDEFFDYDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZK4</accession>
    <name>A0A914YZK4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL19m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L19, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZK4"/>
    <dbReference type="SMR" id="A0A914YZK4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3466.t1">
        <property type="protein sequence ID" value="PSU_v2.g3466.t1"/>
        <property type="gene ID" value="PSU_v2.g3466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_bL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_bL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3466.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13133" checksum="7BD9F2EFB9DDB06B" modified="2023-02-22" version="1">MSNIIKQLEQEQMKQDVPSFRPGDTVEVKVWVVEGSKKRLQAFEGVVIAIRNRGLHSAFTVRKISNGEGVERVFQTHSPVVDSISVKRRGAVRKAKLYYLRERTGKAARIKERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0T6</accession>
    <name>A0A914Z0T6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine-rich DPF motif domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDPF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0T6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3882.t1">
        <property type="protein sequence ID" value="PSU_v2.g3882.t1"/>
        <property type="gene ID" value="PSU_v2.g3882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042426">
        <property type="entry name" value="CDPF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018785">
        <property type="entry name" value="CDPF1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849:SF1">
        <property type="entry name" value="CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849">
        <property type="entry name" value="CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10170">
        <property type="entry name" value="C6_DPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01995">
        <property type="entry name" value="UPF0595"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich DPF motif" evidence="4">
        <location>
            <begin position="53"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3882.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18758" checksum="5C42B9C85960DB90" modified="2023-02-22" version="1">MKNEEEIAENNLESVPSSSETITNVAVANVPPVEVDKEEKDTEKDEGPEYFQFQCVLCSFDVRARYGDLKIGKLEYQGKVYYTRSPFREFDRTKKVTLRDFVIVGTKCCQCFRDVCVKIQCSFYYEQNYCIPCIMQNRGNFPNKVIEVCNFFIIKIITLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2C3</accession>
    <name>A0A914Z2C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2C3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6045.t1">
        <property type="protein sequence ID" value="PSU_v2.g6045.t1"/>
        <property type="gene ID" value="PSU_v2.g6045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF42">
        <property type="entry name" value="QUAKING RELATED 54B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="209"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6045.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39280" checksum="264ED7D3D432CC1F" modified="2023-02-22" version="1">MSSTSASTSVESTISHISCASTTTATVSASLPNVLGNNNDNDDGGKHGHDMKLWCQTVVESDATASSTQSSGKSSTTAKSDVQQSPSQPSQHQKRFNRNHHHKQQQQLQQNIFTGEYPSAFGHCPNTRAALAFEQLEELMRLCNHEYQSNESYHHAINALLRQIQEIRGSFSPPPSSSSGGASRVSSADFITPICQTLPSPPISRTLPHRLFRRIEVPENPAFNLIGRVLGPKGLTIRELETRFQCRIYVRGQGSIRDPEKAKKLLDKPGWQHLTEELHILIIAGGANKVDVETRLDNASDFISRLLHPTGFDSFKRRQLVSLALLNGTFRPQHLQQRNDRSAQQPQQNQISVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2Z8</accession>
    <name>A0A914Z2Z8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2Z8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6725.t1">
        <property type="protein sequence ID" value="PSU_v2.g6725.t1"/>
        <property type="gene ID" value="PSU_v2.g6725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6725.t1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39595" checksum="B85FD4D1A22C17B3" modified="2023-02-22" version="1">MSRISSMARFRKNAAITDNEDRQRSRSTNRLLDTITKRTNFFHRLAFEHTTSYDESISGYMRRQFGGATTNGRRQLSLRYGTNPHQSNDAELYSLQADMPIKVLNGSPGYINILDGLNAWQLVSELAVATGLPSAASFKHVSPAGAAVGLPLNDAEAQACFVNDLPLDSKRPSLAAAYARAREQIWVLKTPKLKRIKEILGADRMSSFGDFIALSERCDELTARIISREVSDGVIAPDYDENALSILAKKKNGNYTVLKIDPKYLPSEDEVRTVFGLKLKQKRNNAQISPSTFENIVSKNKDLPKNAIIDLLVATISAKYTQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGEKAANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z343</accession>
    <name>A0A914Z343_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z343"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4672.t1">
        <property type="protein sequence ID" value="PSU_v2.g4672.t1"/>
        <property type="gene ID" value="PSU_v2.g4672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="86"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4672.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28638" checksum="C30C07ECF5C31330" modified="2023-02-22" version="1">MFFIKHLFQKYLNLSIFRFSFHHSAILVLFICILFLSHNHWHLKQKLKKNCKIYDFQRKESYLAHLFLDNLNGIEIGGSLHNPFCLNTINVDFTNASTAYKKQEKEVSGGNYLEVDVVAMGDKLPFKNGTYDFVISSHVIEHFFDPIKTIEEWFRVIKNDGFIFMIIPHKDRTFDKPRNRSTLSELILRHENVNPNPKFVDDHHSVWITEDFLELCQNRSWKVVAMLDKDDKVGNGFTIVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3W7</accession>
    <name>A0A914Z3W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bet v I/Major latex protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3W7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6584.t2">
        <property type="protein sequence ID" value="PSU_v2.g6584.t2"/>
        <property type="gene ID" value="PSU_v2.g6584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6584.t2"/>
        </source>
    </evidence>
    <sequence length="147" mass="17057" checksum="F30C0C22493B5ADF" modified="2023-02-22" version="1">MAAFKHHESNKSMEEVEIDVQTSVASPLLFCRKQCFKTETIWTIFWRDHEDIFGVTDGETKIFEKKIPIAERMKFCGNVSASLLTEKWRKIFTDAAFKLTFKDDDEDELEVEMTHGTVTLQRIEEPGHIKAIFNEMVEAYNKISVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z457</accession>
    <name>A0A914Z457_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z457"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7484.t1">
        <property type="protein sequence ID" value="PSU_v2.g7484.t1"/>
        <property type="gene ID" value="PSU_v2.g7484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF154">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7484.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24904" checksum="BC2FC444EF119FC8" modified="2023-02-22" version="1">MQQLFPNEYHFYPKSWVLPAQINDFQNYCSTSKQDSWFIVKPDDGAQGTGIYLIQNPGQMQDTTSKQLIQEYIDDPFLMSDQLKFDFRVYAVIKSINPLSIYIAREGSKRLLSTVFHQMESHGVRTRRLWHGIKMIVVKTVLAMVPEIMLNYEHYFNDVPGPQCFQIMGFDIIVKKDGTPILLEVNSAPSLSIDHNVFSEDVSPPVRSIVDEVTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4C6</accession>
    <name>A0A914Z4C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urocanate hydratase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4C6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7543.t1">
        <property type="protein sequence ID" value="PSU_v2.g7543.t1"/>
        <property type="gene ID" value="PSU_v2.g7543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006548">
        <property type="term" value="P:L-histidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1770.10:FF:000002">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="entry name" value="Urocanase like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1770.10">
        <property type="entry name" value="Urocanase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216:SF3">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase N-terminal" evidence="5">
        <location>
            <begin position="87"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase Rossmann-like" evidence="4">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7543.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31306" checksum="DD4AC28DA5760EC5" modified="2023-02-22" version="1">MDIHHLINEDLFEPLVKYPHEQRKVDVAHAPKRAVPLDNDGKKLAVRNILRYVPTKHHNVLAKEFADELKTYGHIYAFRFMPKFNLNAIPIDEIPAKSQQAAAIILMILNNLDPAVAQFPQELVTYGGNGQVFSNWLQFRFVIKYLAEMTGEQTLSLYSGHPLGLFPSHEHAPRVVITNGMMIPNYSTKEYYDKFFALGVTQYGQMTAGSYCYIGPQGIVHGTTITVMNAGRKYLSTDSLAGKVFLTSGLGGMSGAQAKAAVISGCVGVIAEVSFFFVKNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4F9</accession>
    <name>A0A914Z4F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4F9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6881.t1">
        <property type="protein sequence ID" value="PSU_v2.g6881.t1"/>
        <property type="gene ID" value="PSU_v2.g6881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6881.t1"/>
        </source>
    </evidence>
    <sequence length="787" mass="89483" checksum="8E0CA3E4624B880C" modified="2023-02-22" version="1">MLLFFSQTSNARQKKVDRLVDVAEELSILYDRKEINEQQFITRMNDRYEELGYKPYQVYKAWSKILVNVKTRFESNNNVFAKASDKRMAIIQRKFEPNFCRPGISSSSSSRTNARRIDLSQVFSAANARQEPLLEFLGPDEHERETERVREMNIDTTLPDGRIVETEVLPGNEEEIQDVDEPEGPPTTNRDIVNNDATMHSDDDTTAVRKENGQEGTKLQRKRKRIRTNYTPKRSKKNALTSSIERRSSAQPSYAARTSPTKNIRKAARKTPAAVCLTRSRTTAAAAARPSRQTATISNLRAAPRQRRRTPPAVEEEEEEEDEEDSMNNSEPRRSSRLRDLQTKEQQCFNNLQESASSSSFDTPNQPTQLQQPQKHADERRDDSFEEYAPTSQQNALTTSNRRGIRNQQQPLGVNPLNRRQALLNQQQQLTPSRSQRPDEYHNRLQQRRADKQQLTEQAAVEEPEQITLEHPFQVEQPESAATLSQSRPPQTAEPLPQRQFERPGILRHPIRFGVVSQNPSLDQQSPGNYQQQTDMLPPHHRHQHIAPQYQFQQGVLQQPATLSHFGNFGALQCRPPFLQQQPPGNVVADHQQRTTTSAVNPSLDIQHTASATLPQNQQPPIHEIRQIVKQQIPPPSLQPPPSFTVAGDQQQQTATSALNSSHELRHTAPANPGHIEQFVQPQNPFQQLQQPPVPDMNQPQLQHTAPATLPQQPPANPQVVQPQNPLQQEQQTSASQIRFQQLPPSEIRDPQPSIGFLERITEIHGKFLDSVNQILGNINNCNNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5S3</accession>
    <name>A0A914Z5S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5S3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8037.t1">
        <property type="protein sequence ID" value="PSU_v2.g8037.t1"/>
        <property type="gene ID" value="PSU_v2.g8037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8037.t1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42766" checksum="F93EF856DA937D08" modified="2023-02-22" version="1">MQELIALLQQKGEDIMKDFDINSLPPELREILGMLPRFNAGQKAQFLYFIIKDGKVYIGLSVDYYRRLTEHPHGNECGELFQDDGEVQMKVAPIGLMNLLAGMDIETCCIYLKSIDVLEDKNQLVNRGQGIFASQDTVLKNIIEHEDNPQRPIIITAMNQLFNEVMTNGITIELTGKRPISLTMADLKTAQNRNVLQLQNYSTTVSLSQASQFSQQSQSSLLSQRLLESLPELNQLLNELCLVHETDVPQREGKLYLMCKKGTKVIERFGVTWDVKQRRKEHITRATFGGEYDMYVSPIGPQNLLVVMDLEAANIRLSKQNAIKCSKYNANKTNDVGRIHSLFIEAIVVNPLHERRPWLVIALNQLNKLTLDHGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6H0</accession>
    <name>A0A914Z6H0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6H0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g828.t1">
        <property type="protein sequence ID" value="PSU_v2.g828.t1"/>
        <property type="gene ID" value="PSU_v2.g828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF7">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g828.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15054" checksum="1A7AD0EB7396DE83" modified="2023-02-22" version="1">MVGERGLKLSGGEKQRVAIARTILKAPPILILDEATSALDTATEQDIQQSLDLVSRDRTTLVIAHRLSTVISADEIIVLKDGQIAERGTHRDLLLQGGLYASMWDRQREADEAEARLRQVRENDEMGIVIRGAPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6H3</accession>
    <name>A0A914Z6H3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amidohydrolase-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6H3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7503.t1">
        <property type="protein sequence ID" value="PSU_v2.g7503.t1"/>
        <property type="gene ID" value="PSU_v2.g7503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF48">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="53"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7503.t1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48429" checksum="7E07011FFCF23825" modified="2023-02-22" version="1">MADYRGKIVEPNLVWINDKFEAGIKLKISQNGIIEEISREISGDVVELPQFALIPGFINAHSHAFHRNLRGQSGIGCQESDTFWKWRDAMYKLVENISYDNFKQLCKGTFEEMINAGITTVGEFHYVHHENDRFNLDNAVIEAAQEAGIRLVLIETLYSRSGFNAETVNKEQKRFESKIDEFIKHLKILEKSTNSTTTLAVAAHSTRAVDTEGIQTLWRYASENNKSFHIHLEEQPKEIEDCINSFHRLRPSELLLDKMYPVTSKLTVVHCTYTLREHLNVFAKKDVNICICPLTEGFLGDGIPDLNDTDHLCLGTDCNNRINFLEEMRWLTYCQNMKHNRRNCCKLDATKLLQIATFNGAKSLGLEGAVGKFEVGQQFDYVAFDLESKRLKDFKAPNMLLDAVIFGAGNEEIAAVGVAGIERKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6J7</accession>
    <name>A0A914Z6J7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6J7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g755.t1">
        <property type="protein sequence ID" value="PSU_v2.g755.t1"/>
        <property type="gene ID" value="PSU_v2.g755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g755.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12847" checksum="81922D82892CD585" modified="2023-02-22" version="1">MFNSGLQTPNGNNNNNGVIGSQLNMAPQPPTTFPIFTPRQNIPPSSYNHQQQQQQLPHPSMTSEPKPSATLPKTMTAAEFHLTRFGSFRLSVSPPDSLMVNEEEEDDEEKLSAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7T8</accession>
    <name>A0A914Z7T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone H2A/H2B/H3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7T8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6312.t1">
        <property type="protein sequence ID" value="PSU_v2.g6312.t1"/>
        <property type="gene ID" value="PSU_v2.g6312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="2">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6312.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10369" checksum="9BC9E37350C09A28" modified="2023-02-22" version="1">MNSVNMQCRMVNNGSYAVPKLRMYRLIKEIVQQNNAELRMQSAAVAALHTAAEAHIISYMEDLSILASHGGRITIKLKDSVTLKLLKGENLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7X1</accession>
    <name>A0A914Z7X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7X1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8784.t1">
        <property type="protein sequence ID" value="PSU_v2.g8784.t1"/>
        <property type="gene ID" value="PSU_v2.g8784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044194">
        <property type="term" value="C:cytolytic granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038847">
        <property type="entry name" value="Granulysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15541:SF2">
        <property type="entry name" value="GRANULYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15541">
        <property type="entry name" value="GRANULYSIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037413665" evidence="2">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8784.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11697" checksum="15D56D97463AFE6F" modified="2023-02-22" version="1">MNKTLIVFAFLGLFLVEAVQRPQTRGIACKLCKDFVTDLEKELENDEGTIEQKAEKVCDKITMNDPTLDKLCKQFIDAEIDKIVKGIENNDPPEKICKDISFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7Y5</accession>
    <name>A0A914Z7Y5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamine amidotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7Y5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8011.t1">
        <property type="protein sequence ID" value="PSU_v2.g8011.t1"/>
        <property type="gene ID" value="PSU_v2.g8011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Carbamoyl phosphate synthase preATP-grasp" evidence="7">
        <location>
            <begin position="161"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8011.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25693" checksum="A3F023AEB5E8BB5B" modified="2023-02-22" version="1">MVSSLIKSLSKILSSKSNPKPIFGICMGHQMLAKAIGAETYKLKYGNRGHNQPCTHGDTGRCFITSQNHGFAVKADTLPQEWMELFINENDKTNEGICHKSMPFFSVQFHPEHCAGPTDMIILFDVFIDAVKKAKNDETFVVRDLIKEKLFYQSTYKILQQTKVLILGSGGLTIGQAGEFDYSGAQAIKALKEKGIGTVLMNPNVATVQTAKGFADKTYFLPVTKEYVEQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z871</accession>
    <name>A0A914Z871_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovule protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z871"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8063.t1">
        <property type="protein sequence ID" value="PSU_v2.g8063.t1"/>
        <property type="gene ID" value="PSU_v2.g8063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8063.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9672" checksum="6AE363AD3883684D" modified="2023-02-22" version="1">MLNGYIEFIRVFVDSNQYFFAIYINLGQHLITLICCKILHNVNKQKYKSLAYKSSLSERHQECRVQWLCIICFTIFHFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8A6</accession>
    <name>A0A914Z8A6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8A6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8128.t1">
        <property type="protein sequence ID" value="PSU_v2.g8128.t1"/>
        <property type="gene ID" value="PSU_v2.g8128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8128.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40219" checksum="D434E1761BD06346" modified="2023-02-22" version="1">MIQQIQIVLSIAHKVGLVNSVLDSVTFDRVTNALLPDDVATFADWAKFKNVFISLFDTKHSLFADRYKAFQMEWLGPAYEPLQEFVARIRRSVAMFKFADFSENELSTLLILMAMKAPALESLRSLALNALIKTPKESLANVETLLENALMTERDQKLPEQQHVNFVKKVKFSPSSSKKHRHRTSSPSSVSSTSSNDSSSSRRGSCDSCGANHARSQCRLRNAECHACGKSGHIKKVCKAGKRKMDNAQSSSKESHASSRSNKKVGFVRVMPVRVVNARRRPSFAASIDASSLHLQYDSGSDITILSRRDYQNVGYPTLTPSYVKARAADNRTIKLDGYFSATILCSNISKSMDIHFALWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8D9</accession>
    <name>A0A914Z8D9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8D9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8943.t1">
        <property type="protein sequence ID" value="PSU_v2.g8943.t1"/>
        <property type="gene ID" value="PSU_v2.g8943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8943.t1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41118" checksum="6F441DF8DAA328B3" modified="2023-02-22" version="1">MKTEHQHYRTILTPTNDRRRILAPRTSEEEALFIAKKYLENKAILEAKLANAVNGGRFLRQNMLDVVAAELSAKFNVATRNRKYVEQKLRDMKKEARKYLNMAKSTKVLETGEVVLNCPKTPPSPIRVMMQAMADDHLSFTGADSSSWTEQDFSDTTSKAEGSEAEDDYGNIVKSPNNIVNNLDSIASTSSSSSIDLGSLTSTTNILGIDSILGAYFNQPMFAAMASLSNVCASNNNNSKDEIVDEEDDEISSTVLLPPPSSSAPKQPQQQQQTRSRRQQIYRIRRRQQQNHPRYYSCRTKIPESHILAAESFRKLCDTLLEIVPRAAKTFEDACKLQSEYFEQLKLQVSLASFASQVNNNFRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8K8</accession>
    <name>A0A914Z8K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8K8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6581.t1">
        <property type="protein sequence ID" value="PSU_v2.g6581.t1"/>
        <property type="gene ID" value="PSU_v2.g6581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6581.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8453" checksum="D158810134F8B2B0" modified="2023-02-22" version="1">MLCNENTTVLYDRVLVSDFPSSVIIIITFVTAIFGLICIHVTLAVEACIQKSSKQLLEQTVMREEAPDYYLGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8N9</accession>
    <name>A0A914Z8N9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">[Protein-PII] uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8N9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9040.t1">
        <property type="protein sequence ID" value="PSU_v2.g9040.t1"/>
        <property type="gene ID" value="PSU_v2.g9040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05401">
        <property type="entry name" value="NT_GlnE_GlnD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="BIFUNCTIONAL URIDYLYLTRANSFERASE/URIDYLYL-REMOVING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320:SF1">
        <property type="entry name" value="BIFUNCTIONAL URIDYLYLTRANSFERASE_URIDYLYL-REMOVING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="6">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase" evidence="7">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9040.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29453" checksum="55210400DD94C797" modified="2023-02-22" version="1">MNTLPEQYANTALPTLPGQPQNPCVWPRDELTVGGIKAHIDTFQRWLGDAFDNGISAEQLIEARTEFIDQLLQRLWIEAGFSQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECILEGLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARPGGIKRMSAYIVAYSLCPASGRQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAG4</accession>
    <name>A0A914ZAG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein arginine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7237.t1">
        <property type="protein sequence ID" value="PSU_v2.g7237.t1"/>
        <property type="gene ID" value="PSU_v2.g7237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="7">
        <location>
            <begin position="106"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="6">
        <location>
            <begin position="363"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="8">
        <location>
            <begin position="540"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7237.t1"/>
        </source>
    </evidence>
    <sequence length="723" mass="82823" checksum="F1E7E8585608440B" modified="2023-02-22" version="1">MGKKNRKNKAEQRQVSQPPTDTSEATQEHSECINESDLLSDVGTSNSNAQLATMIGPRAVPNIGWGATPAQHSLKMNYDTNLSRLCKAVGTDGYHYMAFPVGGLVRATYQFPEDPSASIEGIPPLKLPDVQFDRYLWETYITGTISPWIDTDNPNETRASASINALRMELKHAAYLGLRTVIVPVNRINCKNLLRVVNHFLWIAVSEFNIVLLLPSNKKHFLDHEDMEDDDIFNFWITIRSNLKNYHSEKLSVGLKLVEETMDAEFNDSTMYSRWNGEPLNLFVLTAETFKFVPSTTNLNSKMDYMSVSHKTLITDLCTAPDAQKFLVAPDSQIWPVQRKQIAEYLTPIITNAINSRQLPSEENWDITLNDRLLLPMETIWRDLSSTEYDSMESDKCKYNLYGEALTKVLQSLSITFNHGIVIYILGAGRGGLISVCMEVIKNRIQVNLHNLISIIAVEKNPHAVMSMSYKNESLWHRKVRIIEGDMRFVLNDENLPKADIIVSELLGSFGDNELAPECWQSSLPILKESTECIPFQFGTFAAPICSPKIRDQLRDSFVSVFDKERAVSAKFDKETGRFNYWRPKNWYDHVFVCPMKRFYEVAPPQHIAQFKFPKLNEDLSNDRHTVVKYDIKHSCEINGFAGYFAAVLANEVFLSNSSHFRKGRITCSRSWFPCYIPLRDGIHVKGGTELMFYFWRKTSNIGTWYEWRVEYTVSLFHTYFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBD5</accession>
    <name>A0A914ZBD5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome non-ATPase regulatory subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">26S Proteasome regulatory subunit RPN11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 19S regulatory cap of the 26S proteasome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M67A family. PSMD14 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBD5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g962.t1">
        <property type="protein sequence ID" value="PSU_v2.g962.t1"/>
        <property type="gene ID" value="PSU_v2.g962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="13">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g962.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34843" checksum="2B6E2726DE5ECF3D" modified="2023-02-22" version="1">MERFLRLGNLGGGLGMGGTTAPADSNQVDTSETVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDEYTINVVDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSDRAVAVVVDPIQSVKGKVVIDAFRTINPQTIALNQEPRQTTSNIGHLQKPSIQALIHGLNRHYYSIPIAYRTHDLEQKMLLNLNKQSWMESLQLENFTTHCQNNEESVSQMLKLSQLYKKSLEDEENMTDEQKAIKNVGKQDPKRHLDETVNKMLADNIVQNLASMMDTASFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC91</accession>
    <name>A0A914ZC91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC91"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9940.t1">
        <property type="protein sequence ID" value="PSU_v2.g9940.t1"/>
        <property type="gene ID" value="PSU_v2.g9940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9940.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10340" checksum="7DE39A9A5E0464BD" modified="2023-02-22" version="1">MQYNTVYVGNFPYDTTPDYLRYVLNSCGIVKYIKFIYDQETGCSKGYAFCKFAKNSGALFAIENLDGVFLNGRKLRVHWAHEKQNHNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDI1</accession>
    <name>A0A914ZDI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDI1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9733.t1">
        <property type="protein sequence ID" value="PSU_v2.g9733.t1"/>
        <property type="gene ID" value="PSU_v2.g9733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037019185" evidence="1">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9733.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16607" checksum="2EEE57026F5D4B1B" modified="2023-02-22" version="1">MKFSMYYILLLSVIFVAAIEFSEALKPKDKYILQQLMSFEGLTKRRSARELLGKRSAFRGRELWGKRSAPPMEPEADYSIQGLQNENESQQWLAAPKKRDGRELLGKRYSPTFEDMDDKGIAYLISILNNKRERRARSNELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE25</accession>
    <name>A0A914ZE25_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZE25"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8528.t1">
        <property type="protein sequence ID" value="PSU_v2.g8528.t1"/>
        <property type="gene ID" value="PSU_v2.g8528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8528.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19072" checksum="E9003747B52D3624" modified="2023-02-22" version="1">MASRRSIRGRGNLHSQRTGNKSIKITLIEDEPELGFTWSKYGNEYGKTQGKQLQKYCCTKCRSIYDKKKKTAEDAQPIPCLIFNIEENKFESENPNHEHYCRPQNLNQIRGKEVARNELAKIKDTRDKPAAVHVKLAESITQRFGNRTEEVKLDIARAAPILSIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZG22</accession>
    <name>A0A914ZG22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZG22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9232.t1">
        <property type="protein sequence ID" value="PSU_v2.g9232.t1"/>
        <property type="gene ID" value="PSU_v2.g9232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9232.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13644" checksum="EA896563460B8AC3" modified="2023-02-22" version="1">MLVKSVTEKSTSSAAFICGVLKYCIAKKTVIERSQPYQYGFDDAARLIYLRTVVRFQNLDTGSDIEEKRKSKVEFYSQPGDKLHDNLPKKLGGSSLMGNWFPLKSNTNIKEWESALEKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZI60</accession>
    <name>A0A914ZI60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZI60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9992.t1">
        <property type="protein sequence ID" value="PSU_v2.g9992.t1"/>
        <property type="gene ID" value="PSU_v2.g9992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9992.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17439" checksum="9CA5B2E43E161059" modified="2023-02-22" version="1">MSEQELLGILDWIKFYEKDYKVVALVEGIYYSNDGKPTERLEEVKKQLAKAVEWKEKQVKETEVFPPCNSEWHKDSGGRVWCTTKSGGINREWVGVPRRLFNSATKSYRCACVKNFGPPLASPGSKGNRGDLDNPSLKEYDDCSSTANSCKIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSZ3</accession>
    <name>A0A914XSZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XSZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11086.t1">
        <property type="protein sequence ID" value="PSU_v2.g11086.t1"/>
        <property type="gene ID" value="PSU_v2.g11086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433212" evidence="3">
        <location>
            <begin position="16"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11086.t1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42497" checksum="6AEDB1BE7205D8E2" modified="2023-02-22" version="1">MLLILIYCIFGIVSADKLLQIQTVCRHGDRAPEGTYKNDPYQEDFWPMGWGELTTVGMAQHFMQGTKLRQKYIDKLQLLPPKYEAKYIYVRSDDSTRTIMSAMSILAGFYSESNGTHPDIPEWPNNFSPIPVHNVAHDTDHLINAHAKCPRSTFLRDAALADKKFLEYVATVLPYLEKVSEQTGDPPTDFKSFGNAFDAIYIEKQHNLTMPDWITDNLYANLLNLSYTLVDIMNGAPNFGRKEDTELIMLEGGVLLNEMIANMENAINGDNKKYHLYSGHDTTIAAHLRTFGAKEGALGIVTPFFGSMSVVELWDGDGKPYIKLWYSDNSAVPFRDITQFIGDCGGKDKCDFENFKVRSQPYIATPENIVEKCDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT31</accession>
    <name>A0A914XT31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEPDC5 protein C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g10430.t1">
        <property type="protein sequence ID" value="PSU_v2.g10430.t1"/>
        <property type="gene ID" value="PSU_v2.g10430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="2">
        <location>
            <begin position="127"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="DEPDC5 C-terminal" evidence="3">
        <location>
            <begin position="1220"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10430.t1"/>
        </source>
    </evidence>
    <sequence length="1465" mass="170412" checksum="628D004AEBB71529" modified="2023-02-22" version="1">MSGQNYDIRDYPVQDIVLEEPDFDDGFDPDKYILIMLHYHTDDSVEFNSRLWPGIQVGDLLEIRSTVTGEKFICRLDIDTAKEVRGCKDNLFHAPSKLFDIVKHAFPNRTEVYLRKIDKDNVTLDSIELTFKEQYVSRTDMWRFKQCMIDTVVHVTKVEHWLGIKCTVSDLWQGGDMKYSGYVSEKTRVVFRSSSSQVLIFIQFSAEMWDMDAQGDLYFERCCMGFLPKLFVRWAEHSCAHHVSLIVVSRWYFNEKLMTDEMRHQLSGNIDHQKRYYQDFYKLVVQNEHYSDWKHVLNKLKEAFFLYKASIQNYLTANFPSYIGNDDEPLIEISVASDGNFLEVLNLSMNSFFVYHSDRRFETTGQQILFVTPGGGVFHVDRNMVNLTKQRLIDMGISLDIVCLGEQPYHAVPLFIFRGEMGNDVYEDYFIPHWMNYSYYHNKPRSSVGPTIKRRVNYPDIGLKSENVKMTIIPSIDEEFDENVDDPYTKYDEKQCEMTHSFAQQNVLLQELCRDMDVQYLLEEEHQQNDIRGNTPQRTTHNSGDRPIVGSFEDARNALEEYAEEGRAGSLEDNKRGTPQPQSTPQPFINPNWEPVRALINPFRPEDYIVRITANRRRWIHVFPVDRLGRAKLAHHYVVGTSTKSILKSVEPLPPSDSQIGNSTHNSPAHRPISPQTPPIDFRDPRDPTNASRVTGRGAKGITTVWAWGSTGEEKWNPDMEIGMDWKSLIRSGLLPLTTDFFPDSRSLSDYLLSEHKVEVETEDVRKWVPMERRCDITDAELLQILFEQLIYQRLQRGYQIVVLPIVFIEDATRDLIPDMARRAFKHCKQQCTLSLNHIYHRIMIIEHTQYVMLQHFAPKSMNTKGIENDKNRYGESEKLQIYNYMFQVPDDFNYTASATSFKHHNLDKINWSGLDACVQTRNNPGHYMDVLKCFSCRFLLVPNIDYLISVAMSEQRGDVFNFNEIIHAEKFEFNFVRFVELINRMKNNAVAQHPRQPSVASSGPSTDKQAQEFLDQHIASFPQFISINIIPELKASEPDRIVKEYLGMVLEYPLQHTITGDVLPPNVIVSYDFILWIRSSVLGLERRAAAIEFCQKLVTDKKIRILQRPESFIAFDGNRFENVQFSTDKFHLGFILYGVKTDYCYTQEHFDELASQVNVNEIIQVEVVEDKNLLDDRDVEIGRCQSHKQKNKVPKCMVRMQEASMEFSQAVHVRDPKNSYVEWGRILAESMYTTGKAYEIWVKWLMATGQTVVDIVLKNWARGGSRIGFHLFAVPEDMFAEPTNPLSSPLRCPIFVPVNTAVIPKASFDFIMRRAIKAFGFIPIKCPEHFNKKEQKSELQYVHMCGGMLVKYEPHLKRFLWSWNHMFSQLYRSPICTESFLDMMLKDFREFFDDKSSRLSKFIFNNYCNLSNFKPTELSSVLRSDNFLFDGTWETLEDIQNASNTCAIKDGILKFLIKLEHSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUB6</accession>
    <name>A0A914XUB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUB6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10558.t1">
        <property type="protein sequence ID" value="PSU_v2.g10558.t1"/>
        <property type="gene ID" value="PSU_v2.g10558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000015">
        <property type="entry name" value="Nuclear receptor subfamily 2, group C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="227"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10558.t1"/>
        </source>
    </evidence>
    <sequence length="553" mass="60211" checksum="9D6D899E00A67AD6" modified="2023-02-22" version="1">MPQYGIGSQNGSPSLGFSGAESTHSGAGLLSVNSPKDSCYELCVVCGDKASGRHYGAQSCEGCKGFFKRSIRKQNQFQVGYICRGSKDCPVTKFHRNRCQYCRLKKCITMGMKSESVQAERKPMISSSRERDGLSSRNKNCSTSTDGATTMNESSSPTSINEFKFSTEAPLTALSDRLTASPNSTVQRPSSTSLTLNCKREPGDADSGVDMSITTALTTVSSTSPTTSASGMDCMHAASDDETPLPAPSGPILTNSCMEFVLPIPQQVPDDLQNTIQFMCETASRLLFLSVHWIKNIPTLSQRAIPLGTTMKAKWCDIFVLGLMQCAPEFSLSNILIAMSTHLSTCARFGRLKAEKFDEVNDQIKKLIVLIEKVSDLKISSTEYAYLKVIAFASSDIVELAQRAHYRHVNNAACQELYDYILVNFQTLMDDNLSENDGHSEATTSASSAVSQSASQDGRQTANSENSSNQVDHNNQATIAASIERYSQLLQLLPCLRWFKQPVLVELFFSGLIGNLSIETVMPFILNTDIMAIFDNAAGADAQTSLAGMMLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVN7</accession>
    <name>A0A914XVN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11037.t1">
        <property type="protein sequence ID" value="PSU_v2.g11037.t1"/>
        <property type="gene ID" value="PSU_v2.g11037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="664"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="109"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="295"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="627"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11037.t1"/>
        </source>
    </evidence>
    <sequence length="813" mass="90099" checksum="B0EFFE5D03520410" modified="2023-02-22" version="1">MTTPSSSKSSNPSNDYDYNVDSKIGQIIFEQQVLLPLFTRIKYKGCRSSDFSDIQQVLLYIFHSFKIQKRNYLVDIFLKNNVYELIFDRPKPVEKIVEKPKDLRKRPNVIVFNNWKMTAVMWCVAPFLTLSLFLSANAMKKAIKIEMNAYSFAGSIATEVISGIRTVMSFNAQAFEINRYHSCLLIAQKLGIRKAKITATFSALFSFFQNFAMAVGFYAGAILVFRGEMINGQVIGVYFAVIMGATRLGQAAPNLNAILSAKLAAGEIFSIIDKKPKFNCTTNAGFKLEDVKGDIAFKDIHFSYPSRPTIQILNGISFSVKSGQKVALVGHSGCGKSTTIGLLMRFYEASKGCITLDGIPLEDFNISWLRKTIGIVSQEPVLFAKSIEDNLKLGQEISMKELVEACRTANAYDFIIKLPQGFETMIGEGGIKLSGGQKQRLAIARALVSNPKILLLDEATSALDTESERLVQDALDRASEGRTTITIAHRLSTIKNADLIIVFENGTIVEEGSHESLLEKNEAYAKLVSAQTINKNSDIGIDADENEGDYESAVEDELFVRGIRRSASESADEIDRKKRESIRLSKSIANVGTEIVEDTNIEKAKISTTFCDIFKYAKPEQRYLISGLICSILTGFRYPILAALMGLFFAVLAKLPEGEGMDEAFWIGMAFFALAVVSCLTTYFSGFFLGSAGEKMASRLRMAVFTNIMHQDGYYFDQTSHSVGKLTSRLASDAHHVQGAIDQRLAEVLVGITSLVSGILLCIWWGPYVTAVCLIASIIFVTFKIAMSNYLKKRGLKDLQSAEESARVNFKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWS0</accession>
    <name>A0A914XWS0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid droplet-associated hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipid droplet-associated serine hydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36403"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17002"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:36404"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.13" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914XWS0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11411.t1">
        <property type="protein sequence ID" value="PSU_v2.g11411.t1"/>
        <property type="gene ID" value="PSU_v2.g11411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11411.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24168" checksum="01E1FE9A14A35236" modified="2023-02-22" version="1">MNHEIFTTWLKVSHKYTRVTRQRNFIPKQNEEEEKAKLIFVMIPGNPGNDKSYDRFGEQIFEEMSQKEFHIPTEFYSIAYLNHVELPNHLKNEESDITTHDDIYLLNDQTDHKFNFFMEYMPKNIPIILIGHSIGAYIVLKILPKLVENGFNIVKVIGLFPAVEELASSPNGVKFGGIFKVRFLVNANKKHGTLAACHKMPMLIISMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXH4</accession>
    <name>A0A914XXH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXH4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11660.t1">
        <property type="protein sequence ID" value="PSU_v2.g11660.t1"/>
        <property type="gene ID" value="PSU_v2.g11660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000193">
        <property type="entry name" value="Tropomyosin-1, isoforms 9A/A/B-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11660.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21831" checksum="28B70242E420BA6E" modified="2023-02-22" version="1">MSKFEKGGSQQTSLLDVLKKKMRQAREEAEQAKDEADEVKRLLEEERKKREDAEAEVAALNRRIVLVEEDLERTDDRLKIATQKLDEASKAEAEVASLNRRMTLLEEELERAEERLKIATEKMEEASQSCDESERARKSMETRSQQDEERANILEVQVDEAKVIAEDADRKYEEVQTYFFSFSLFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZQ7</accession>
    <name>A0A914XZQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial uncoupling protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZQ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12013.t1">
        <property type="protein sequence ID" value="PSU_v2.g12013.t1"/>
        <property type="gene ID" value="PSU_v2.g12013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000062">
        <property type="entry name" value="mitochondrial uncoupling protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="216"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12013.t1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36050" checksum="FCC364F63E3295B8" modified="2023-02-22" version="1">MPHPPGNDLSNSTSAKSIAFKYVLSCSAAMVAETVTYPLDITKTRLQTRAIPGIIPKKPSGMLRVTYNIARHEGLLSLWQGIAPAIYRHYVYTGIRMGIYEVMRSKWKDPNVKEFAVWKSMISGAFSGAFAQFVASPADLIKVQMQMEGLRKLQNLPPRFKSTWHAGKLLYRSNGIAGLWIGWIPNCQRAALLNMADLATYDRTKHWLLHNTNMKDDFLTHGCSSACSGLAAAIASTPSDVVKTRIMDQLRHLHDHKHNEQARMYKGSFDCLMHIIRTEGFWALYRGFLPTYIRMAPWSLTFWISYEKIRYLTGAPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y002</accession>
    <name>A0A914Y002_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y002"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12106.t1">
        <property type="protein sequence ID" value="PSU_v2.g12106.t1"/>
        <property type="gene ID" value="PSU_v2.g12106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12106.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26875" checksum="847B411C4CFB7ADE" modified="2023-02-22" version="1">MVKWSTVPPWRTEWAEEPPWNLERKLRRREKLGTPVRPILGNKQDLRQSWRRSADNLYRQQYPQYQTPQHPRRQPPTPQPRHLLQTPQPRPASTPQQFQPSSIPIPVVQQQQQQIPAPLQPQQSQLQLQQPSQPPSYQTRSISSPIVPEKASIRNYEEQCRERRQSKRRSKSRNKEAKEAKEIREVEEFLRRKSPQRVSFTRRAPKVYQRTPESSISGGPKEKHTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0A6</accession>
    <name>A0A914Y0A6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0A6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11304.t1">
        <property type="protein sequence ID" value="PSU_v2.g11304.t1"/>
        <property type="gene ID" value="PSU_v2.g11304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11304.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16428" checksum="65E54DBFE5C91C91" modified="2023-02-22" version="1">MNQFQNKHHVGHTAEQSLRSVFVGNIAYAVTEEELTELFKTVGHVIKFRLVRDRDTGKPKGFGFCEYKDVQTAEAAIRNLNEFELHGRNLKVDSAVNSANEKHGPEEFLSQTCTVEGGPERFEDEDGQYGAAVEPEHVLEAITHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0L3</accession>
    <name>A0A914Y0L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0L3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13742.t1">
        <property type="protein sequence ID" value="PSU_v2.g13742.t1"/>
        <property type="gene ID" value="PSU_v2.g13742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13742.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="33318" checksum="F4A04E6F5EE3FAB2" modified="2023-02-22" version="1">MNPRDPRIQRLYGNAQMRFASPAYTSPRLRLGSPPDASTPTTQINNAIIDEKSLKVISPEDRHLHVAFYQSFKNFPLENFNENTRQNAVGALKFIFFNHKKAMEALVMENQIFLKCLNEQDELLKNVPKEDARKNEIDSYNKKIDELNAELQKIKTQNCEDKNGCLQRYDEAMEDNFQLKRKIQKIQSENKKEIEALRKSNREEAEQHAEKLKELKNELKEERSKTSSCMNEISETIKRFTDVRAENRQHRDSSAARKRSKTRSNEGVERRHRDSENSKKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1E5</accession>
    <name>A0A914Y1E5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1E5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13044.t1">
        <property type="protein sequence ID" value="PSU_v2.g13044.t1"/>
        <property type="gene ID" value="PSU_v2.g13044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13044.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13265" checksum="233625E4D546919C" modified="2023-02-22" version="1">MDRIGKPLKRQYMPKDNALYRALSYLVFGNEKYYDQIIPYVEKYKALMEIEFNAMEIVSNDDLRAFAKLFAINILVYIDGIVSKWICYSAGEFFFKNMNQLKKVEYKTGKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1Q5</accession>
    <name>A0A914Y1Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lectin</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1Q5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12713.t1">
        <property type="protein sequence ID" value="PSU_v2.g12713.t1"/>
        <property type="gene ID" value="PSU_v2.g12713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12713.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23244" checksum="0BCFF3BCF321A76C" modified="2023-02-22" version="1">MAFCTFVQKTSCLFDENVFDGYNTAENENNIAQVASPNGNCEIIILNRPVVIFDDLGVNLKYLTHSVKHFWTTSKNQAVKVYRGSVEDELMLEFNSTNGDVWSNFILASTWYTITVPVNSSVYMEFTKFADNTLQISKPGKTLWGTAYYGSKNSAPLRQDTPNIGVLEIYENIVANIKILKFNVSSSGAFNFSLEYGEIHGQEQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y238</accession>
    <name>A0A914Y238_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y238"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13300.t1">
        <property type="protein sequence ID" value="PSU_v2.g13300.t1"/>
        <property type="gene ID" value="PSU_v2.g13300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944:SF2">
        <property type="entry name" value="CPG4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944">
        <property type="entry name" value="PROTEIN CBG02791-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13300.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28900" checksum="43D21DE0FCD01088" modified="2023-02-22" version="1">MFASGQNSTDPECFQQCNEEWKEDFEKELQISCSDFYDFPFHPKILQYNDFIKYCKIAEKQTKCYIKKCGDESADRVFSPSNFLCQFKRSQFLTARPCLEDTEPITFLKCDHACHAKAAQEAKEMNRAHLGKVFTNNELDKYEREVKNDNYNNINKMPKKKFQLSLLCSFQECYRDCHKPILEESCSRALADATIDLIQAYVQWHATDIYDWHILSENVDKLPESCSRLTGYNPNEDPVLKIMNNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2G7</accession>
    <name>A0A914Y2G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LRAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2G7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12976.t1">
        <property type="protein sequence ID" value="PSU_v2.g12976.t1"/>
        <property type="gene ID" value="PSU_v2.g12976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRAT" evidence="2">
        <location>
            <begin position="112"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12976.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="34156" checksum="3B27B27133FD2A65" modified="2023-02-22" version="1">MNKMILDYYDPQEFCEHIESVLRNEWMGDEIVEERLWGETPQKQHLVLIISKALWYAVRLIVDEEYRNLEVSNEYGVYSDGSNNLKSLYFSNYSYRIRKLPSDVIENFEEYLKPGDHIQRNLDGCLPFANHEGVYIGDGMIAHINTEKSTTMTKTLLTEKFEAHARIDPFQGFPSPKNQEIRIVVHCLRRKSRTDICATAHRLADNDVTPEERYYTGEYNFLRQNCQHFASYCVLRIQRMSDNGPIVKRAIIGAANLIGSGVAEKLFFQQKQQKRRESVNSNQTSIEKINDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2Y7</accession>
    <name>A0A914Y2Y7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2Y7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13812.t1">
        <property type="protein sequence ID" value="PSU_v2.g13812.t1"/>
        <property type="gene ID" value="PSU_v2.g13812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13812.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18392" checksum="A9F9E4E6F25188C9" modified="2023-02-22" version="1">MKDTAGTTNKFNIQLSSSDSSSLGLRCQEIDGKVCIVDVRSGSNAEKAKLEKGDYIIAIDDFIVQGKEMNICANILKENIKNNGFVMMLIERSNRLSTSNETLKSLKDPPQISKESLSHSSPPSNGKRKNHTDYEVDPEFSDSSSSHESVTSDDEAEVSEVEESKGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y368</accession>
    <name>A0A914Y368_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Macrophage-expressed gene 1 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y368"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13220.t1">
        <property type="protein sequence ID" value="PSU_v2.g13220.t1"/>
        <property type="gene ID" value="PSU_v2.g13220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13220.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13850" checksum="693DE95BBE077B37" modified="2023-02-22" version="1">MAIDKALEKNLTRRARYLSEAIIRDYGTHVLTRVEAGAKIEQEDFVDSSVLNLKEENLFEFKASIAGNFLNNAFGAGGSMGMSYSTDSKTNETLTKATRHSHIKTFGGPTVNHLLAESLSGAKPAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3K0</accession>
    <name>A0A914Y3K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3K0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1234.t1">
        <property type="protein sequence ID" value="PSU_v2.g1234.t1"/>
        <property type="gene ID" value="PSU_v2.g1234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1234.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17807" checksum="B582D55C5D70C995" modified="2023-02-22" version="1">MIIPFGGENDTCGVEFNTVSGTYWVEIEVHSNNTVETEFDRIFNVTCDNTIDQPKAEYILDLYPIPSNDNQRSTNIEHGKTYFLDAFMPSFDDETKYGNNFRITNCIIETVDDTNAIEIINSNGCSSDPKLISEIDYSNGYATTNISSINPYLKNAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y552</accession>
    <name>A0A914Y552_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y552"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15325.t1">
        <property type="protein sequence ID" value="PSU_v2.g15325.t1"/>
        <property type="gene ID" value="PSU_v2.g15325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034754">
        <property type="entry name" value="GEMIN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15348">
        <property type="entry name" value="GEMIN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15325.t1"/>
        </source>
    </evidence>
    <sequence length="840" mass="95291" checksum="40A20EC3F1870960" modified="2023-02-22" version="1">MDKSSSDHHLAVLEKLRNDPAYAIYWKNWNICQNWMTRNDETYLEYQKSVAWQRAHEDLTSLLDSIKTAEGNVSASVDPSTVGDIPDDGDIVMEESEQLSEFYRISMEHKKQRAAERDRQKEEEEKQPKVEYVDAKDVGIHGISSFNIEKKTFGEKAQEHLAETQKKYGPHAEKIITLEATMNYKFDELISKFAPPLWPNIPFRLKRPVVSSITETAAGDESPDESERPPPIIMAEESPRTRKPITHYDDEEFFNEFRAKNKRRRVKQEIDEPEGEEGNQEQDKQVSHTIDDIPTTSKKAADIKKPPRTSIQKETVTSTPSASTIKRSSAILITPKNEVVEEPDIIPLEHSPPQLQRESISPQFDLSSLYASASSQEKFRKAAASTNSYFLNPNLQKYPRPSDTPPHPRVILPRTVNIRAPATSKFLNHSQNYSLEQPPSVSNPIYTPRGQYHASASSSLLPQYQDKRVRTFHENEAAVKCPDCNLILKNMFAYTTHRNYVHGQAARARIACPEHGCLVMSTSMVGLVRHLNSEHRYCLRHEQRIFKNENEYMDWFRNLVEDGSVSFVRSSGGLQSNDRVSGTVSLMFYCNRSGRKHLNNRVGSLKINAVCPAYFRMTKHQSGYVSVYAQLRHIGHECIPKYKSIESFAPIRSAVNDIELCLQSFKELSKSIIPFEYPMDKNSLVSSCLELLNNVKVDFQRAKLLIDGIIPSEQVEDEAFPAYDDELFKSAADVDIFALPYPKDSATTKNLTSRKSPVLRFESSPELDDEVQILKQSIYNAAANLENTSVAQISPPPGDTPSPPAVLSDLGSTSSKSGKLDTVRNMDEERIKQYRQTPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5E9</accession>
    <name>A0A914Y5E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5E9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12915.t1">
        <property type="protein sequence ID" value="PSU_v2.g12915.t1"/>
        <property type="gene ID" value="PSU_v2.g12915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12915.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9340" checksum="0E9F074F48D6FF1F" modified="2023-02-22" version="1">MELIKNELFLTLPPSYQKAVEKVEQEFRDIPETDHRAKRDILLEFSLKYLMIKELWDIYFFERFEFSNDCGFYASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5J0</accession>
    <name>A0A914Y5J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12954.t1">
        <property type="protein sequence ID" value="PSU_v2.g12954.t1"/>
        <property type="gene ID" value="PSU_v2.g12954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12954.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27275" checksum="838E31D0B91AA287" modified="2023-02-22" version="1">MPSYEKLIKDKFNATIQSLDFCKTFDAVTNINSFVADSTNNAIKEILTSDDDISAETSLILINAINFIVEEDDWNFQSGEEWQCLGIPYKNRKAWLYIVLPKKSDGLLSVIEKIDYTFIKKCTQRKKTGKMTVILPIIEISSSINLDEKLKDMGIKKIFCDTADLSGIFEKGLSQKIEKIIHKSVIKIDEKGTEASAATGFQMNARSAPQPFFAIHPFLFFITSVEGPASAEPKDILFMGTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6A3</accession>
    <name>A0A914Y6A3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6A3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14780.t1">
        <property type="protein sequence ID" value="PSU_v2.g14780.t1"/>
        <property type="gene ID" value="PSU_v2.g14780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000039">
        <property type="entry name" value="Neuronal SYmmetry"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574:SF1">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14780.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30839" checksum="27BCEC0469B808C3" modified="2023-02-22" version="1">MTFMKKALLALSIVLILVGMGLTFGGVFSPAWQVVDIREFRAEHQHGLWWDCIRAEKHVVAVGDFYDETPLHCMYKFDNSAEQVIENTLQHIDEDGAAGESEHHRFWGWHKAVLTFFVLSFCLAFTALCTGCCAPCFTPCTFVYTIGLFLSMVCSVLVDGIFFFSANRVDIRFVQGMVGTYEQRIGYAFYLHLLGTGALVGAFVCALLTTYKFFQSSGNRKLFEPDYSHRAVPHTVLGWQSRDNKNDIPLKSTTSGTTTKREHLIHTFTSPTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6S1</accession>
    <name>A0A914Y6S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6S1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15904.t1">
        <property type="protein sequence ID" value="PSU_v2.g15904.t1"/>
        <property type="gene ID" value="PSU_v2.g15904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF29">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="468"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15904.t1"/>
        </source>
    </evidence>
    <sequence length="510" mass="57737" checksum="182D3BAE26EDC59A" modified="2023-02-22" version="1">MSLIENEHLQKLLSYIPNFKAPKLRKLKSLMIEKLERILDYAKANCTGNFLAIGTDCGTTKGMSYSYLAVSVHFIDKKRKALTCASFELKELKGRHTASFLRTTLENALKKAGLDVSNISKIVSDGARNMVNAFFEPFKVTTEEDGSESMEEIADDAHLKLLDDYEKFLLSDEDVEEFQFLVEAIGEDDPNNLHCVAHRIQLVLKDVFEKEELLAVRKTVFQTINHFARSHQATSELYERSKSRLLFPAATRWSTLTVTYERVLKLKDHINIVALEHGWPTLTKQTTDAMENVLLLTKDLTDFTTTIQSDSQPTISLLYPGLHNIKTNLQRKKSEVKVHPNIDFEEVIDALINAIDIRFDDVLSTNTDDGDKIFAAATLLDSTTAGLFPDLEELTLQQTKKIFYAMAKKLNIKHDENENTEEGGSATQPMIKNRLGFEIQAPTSQLVTTTKKTLGKEITEFFSSVKEGNWNFNRPIEAWFLHQKQYPKLFDMAMAILAIPATSAAVERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7S6</accession>
    <name>A0A914Y7S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7S6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16256.t1">
        <property type="protein sequence ID" value="PSU_v2.g16256.t1"/>
        <property type="gene ID" value="PSU_v2.g16256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16256.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20177" checksum="C520FE5D14F320D1" modified="2023-02-22" version="1">MIKYFLVLKNVFCTLKQGCWQVCSTLDSNETPLNLALNKKFKLHLNGRLSIFFGQAHVSTLLKHVSSCNLTKLQLGSQTITWTEYLKLVSSQTLKIVEFKKCIINDNEGNAIEYEKVLKELPNIEEFEIIFNDKEVTEKTTKMFSQIQQFSNLKKFCVGNLPESFDFKAFSAFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7Z4</accession>
    <name>A0A914Y7Z4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7Z4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15395.t1">
        <property type="protein sequence ID" value="PSU_v2.g15395.t1"/>
        <property type="gene ID" value="PSU_v2.g15395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15395.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16813" checksum="F1F7D3A1EF85B2F4" modified="2023-02-22" version="1">MKPDAKYDALFDRLNIKSTDHILEIGCGWGHCAIRAVKRFGCKWTGLTISEQQFELCKKRIKEAGLEDKIDIKFLDYRFDLHFWGMRILGKICKILGETGIYDKVISIEMIEAVGHEYFPIYFSTICNRLRPGGIAAIQGLLDFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y847</accession>
    <name>A0A914Y847_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y847"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13771.t1">
        <property type="protein sequence ID" value="PSU_v2.g13771.t1"/>
        <property type="gene ID" value="PSU_v2.g13771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36937:SF1">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36937">
        <property type="entry name" value="PROTEIN CBG20935-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13771.t1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37641" checksum="7C37D97197370A24" modified="2023-02-22" version="1">MVFHKVKQEPEKLGIELIPFHLEELEHLNNAYSGNSEKYKALIREYEKKTAKAFASKTAQGNGEEEAEKHKQKDIFKDDDTEVDGFIEQEAGFEEEKLQPQVMSIQQLQAGHIPLSQLGLKKEQVHALCQKFSVIAAQVCYGHKIEAQYLDKCRGYMSDCAGYISEAKPLGAIANSFNSGVGITYFNVGVNGIPYYAVNEEGAVNAGHNGKVDFGSWGGGYSDTIGVKDYWRQTAEGGANWYEGLYGYKTGWHVPIASQFGVEGGGGTHVHVPLKEGSLGQPIQVSNGYHVGPYLGLAENVGVDWYNGGVSASKGFALPIVGVNGNAGTSVGFPSLGTVMRAMGPYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y855</accession>
    <name>A0A914Y855_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antifreeze protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y855"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16378.t1">
        <property type="protein sequence ID" value="PSU_v2.g16378.t1"/>
        <property type="gene ID" value="PSU_v2.g16378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037344422" evidence="1">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16378.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9051" checksum="8BFB9C1ECD18CF4A" modified="2023-02-22" version="1">MFASKTSTTLVIISMIVLSIYTLNVNADACSDVKTSSENARVSAEAACAKAAQIAINSSDPTKAVAKKACEDAKIVAKNIADKAAAAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8N7</accession>
    <name>A0A914Y8N7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8N7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15813.t1">
        <property type="protein sequence ID" value="PSU_v2.g15813.t1"/>
        <property type="gene ID" value="PSU_v2.g15813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15813.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15370" checksum="90D50326C5E5E71B" modified="2023-02-22" version="1">MSHHFVPRPPLSSSDIAAQAGTKHIFNAPYLYVKVVGIQDQDDDTKTAIGIDNDTITARHLIDDDSSISTCHNILSDTRTVGNIVSDVNTARDINDKGWFEYIFDFLFPIGSAEDSNGIHQRFNHTEFMPCGAAAFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y904</accession>
    <name>A0A914Y904_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Protein-tyrosine sulfotransferase</fullName>
            <ecNumber evidence="3 13">2.8.2.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-tyrosyl-[protein] + 3'-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16801"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:11688"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:65286"/>
            <dbReference type="EC" id="2.8.2.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein sulfotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.20" evidence="3 13"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y904"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16675.t1">
        <property type="protein sequence ID" value="PSU_v2.g16675.t1"/>
        <property type="gene ID" value="PSU_v2.g16675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000290">
        <property type="entry name" value="Protein-tyrosine sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16675.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39750" checksum="A8A79486A92BE1B0" modified="2023-02-22" version="1">MGVRLRYIIVAATVLFVIFYFYTSSKLPPEQTQGIIQPIVSHDGRFTHESPFIFIGGIPRSGTTLMRAMLDAHPLIRCGEETRVIPRILALRAQWKKSDREWKRLQEAGVNDQVINAAISSFIVQVIAGHGAPAPRLCNKDPFTLKSTVYLSEIFPNSKFILMIRDGRATVHSIISRQVTITGFNLNDFRQCLTKWNAGISVMYEQCNEVGPSRCLMVNYEQLVLHPELEMKKLLDFLEVPWNSSVLHHEALIGKDISLSKTERSTDQVVKPVNLDALTKWVGHIPEDVVADMASIAPMLEVLGYDPHGNPPNYGKPDDIVIKKTKDIHENGEEWYKKAVAVVNDPSRVDKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9W5</accession>
    <name>A0A914Y9W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9W5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14318.t1">
        <property type="protein sequence ID" value="PSU_v2.g14318.t1"/>
        <property type="gene ID" value="PSU_v2.g14318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14318.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="35201" checksum="F54491D995A60189" modified="2023-02-22" version="1">MDIAKRLTDAFTGGSWDGDIDNAPETIQPRPAQPHHHAGFGLRRAPLCLFGAVRGAALTQHRARRTDRAVDRAAVGHAAGAGRRPSHRQRGDRPGCGQPGAGRDGQAYRPPADPDRRCLPRGRQGPPRQPVAERGDRGGQQRGQAAARVPRPHRTGVDAGPADEEPMWRAANGRLPEAWREPIEALADDTRSLYNWAHAATAQVAKGKPDDAARERLQRNLGMALEMIEQQYNLWQAWRREDKDGAPPMARWVTATRDGDLVLHGSPVGLGGDDLGDADRRWRLPVAGDRQRHSRRGGDGLAVVAVRPAQPGRADRAEVPGHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB62</accession>
    <name>A0A914YB62_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YB62"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16649.t1">
        <property type="protein sequence ID" value="PSU_v2.g16649.t1"/>
        <property type="gene ID" value="PSU_v2.g16649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="81"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16649.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23919" checksum="C0A0818400E1EAD2" modified="2023-02-22" version="1">MPLKLQYLSIRYLAEPARLILYYANESFEDERLTQETWEPIKASSPYNTVPILTVDGKHQIAQSMAIYHYLAQKYGLAGKGEIEVAKVEAVGEYFREMMNKILPYLLFLIGKNSEGTKESNYAKYFEPTVKQYLPVMIKLLKESKSEFFADSGATWVDFLVAEYIDSIHGHAPDVLKNYSELLEHSKRVHSLPQLQKYLQSRPTTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBH7</accession>
    <name>A0A914YBH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBH7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16630.t1">
        <property type="protein sequence ID" value="PSU_v2.g16630.t1"/>
        <property type="gene ID" value="PSU_v2.g16630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16630.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22411" checksum="C2887983BFC61CFE" modified="2023-02-22" version="1">MWLAGQETTSNTLAWMILYLMTNPKIQSKMHQELDHVIGSDRMITLDDKMNLNYVNAVIAETQRYCNLIPNNIPHRLTEDFDFHGYHLKANTMVIPQVGSVLTDENIFPEATKFKPERFIDENGKFQTKPELIPFGVGKRACLGEGLARLELYLFAANLFNHFEITVIPSNPPNMIPIVGGTKMPEPFLAHIKHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBL6</accession>
    <name>A0A914YBL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16812.t1">
        <property type="protein sequence ID" value="PSU_v2.g16812.t1"/>
        <property type="gene ID" value="PSU_v2.g16812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF452">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220">
        <property type="entry name" value="IMPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16812.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18025" checksum="A223F01527E72946" modified="2023-02-22" version="1">MSTLVSLRNITKTYQRGPEKVQVLHGIDLDIASGDFVALMGPSGSGKTTLLNLIGGLDNPSGGEISIEGERIDQMSGGQLSTWRSHHQQRVAIARAIVSDPTFLICDEPTGDLDRQSAEEILGLLQQLNREHGKTIIMVTHDPKAAEYATHTVHLDKGELADAPLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDW4</accession>
    <name>A0A914YDW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g15616.t1">
        <property type="protein sequence ID" value="PSU_v2.g15616.t1"/>
        <property type="gene ID" value="PSU_v2.g15616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15616.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45464" checksum="BC61A725C6D4E2A0" modified="2023-02-22" version="1">MTSAQWLSSTYINSDSERIAAKANERSLTQLNSWIEQAATFDGKPMSEDSKRAIHLLKLMSSMPAPRDPAKLAELTQIATRMEGSYGAGKYCXXXXXXXXXXXXXXXXXXXXXXXXXXXXTAPMPTIRTPAAMGELEQVLARSRDYDKQLDAWQGWHSTTKSMRGDYQKFVGLVNEGAKGMGFTDAGQMWRSGYDMPPEQIGPETDRLWEQVKPMYEQLHCYARGKLDKTYGKDKAEVGQRPDRRAPAGQHVAAGLVEPVGPAGTVPGCRQPGHHRGAGKAVPDQPERRAGQGRQGRQRGRAVQGAARGRIAYRQADDRTRAGLLRVAGHAVAAAVVLGTHPVHQARRPRRGLPRQRLGHEHGRRRAHQDVHQAERRELHHHLPRAGPHLLRPGLQPAAAAVPGRCQRWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEC8</accession>
    <name>A0A914YEC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17105.t1">
        <property type="protein sequence ID" value="PSU_v2.g17105.t1"/>
        <property type="gene ID" value="PSU_v2.g17105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.170">
        <property type="entry name" value="Cysteine proteinases. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17105.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15177" checksum="3C1813ED1C91DB69" modified="2023-02-22" version="1">MTVVLLVGYTPDFWIAKTSFGPNWGENGYIRFKRGTNFCSMTRRVIAPFLADSILPTTAAITVAKPAITVSGWTEWAASSCTANCGKCGRTIMKRVCRGGICPGANTFNSTTICGASTMCSFPLSSCCAPAKRAVVNSAIICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEK3</accession>
    <name>A0A914YEK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17884.t1">
        <property type="protein sequence ID" value="PSU_v2.g17884.t1"/>
        <property type="gene ID" value="PSU_v2.g17884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17884.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27721" checksum="7E2554ACE82D3B16" modified="2023-02-22" version="1">MFGVQPIDAFVLEIMLNEVTDSGDSASHEVEKNRRFDVTTQTNSYESEELGRIGNELVALGLDLSDNPPIIPSTHTSAHSSPLHRQHSLIIDSQTSHEMISPPCYSQSSTTSSIISSTTPTSSSSTNNNNNNSHKPPPLIVNNINSASSGHLSNFHSPSHNPIVSAPVYPFYFNYQQQQSITSNGFSFDNIHTNGIQSAGPFNNQTFFDQQQQQQQQHHHHPQQQQQLQQQSQSHNNNNGYQSPHDFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEL0</accession>
    <name>A0A914YEL0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YEL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18703.t1">
        <property type="protein sequence ID" value="PSU_v2.g18703.t1"/>
        <property type="gene ID" value="PSU_v2.g18703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF7">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18703.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35619" checksum="648938EAD84D1CB1" modified="2023-02-22" version="1">MIHIGNLMININGELYDLDKKFNKTKDPVNSEEGSKCSGFIKVTPNNADLLISQVTMSGFQNLLRVLKLYKFGYDERMFPGHTTTFASYPGMLYSSDDFALLSSGLGILTTNKQASIETTIAVWNQTLYDYTKAENQLHTWVRTIAANQLARTGREWCQIFRRHNSGTYNNQWIVLDYKKFQPYRNLPDHGLLYVLEQMPGLIVYKDITGYLQENKYYASYNIPFFRKISEVSGFAKKEKELYWYSWSDCPRAKIFKRDHNKVVDLETLKTLMRYNDYTHEPFSRCNCTPPYTAEAGRLLFFLSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YER7</accession>
    <name>A0A914YER7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YER7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18763.t1">
        <property type="protein sequence ID" value="PSU_v2.g18763.t1"/>
        <property type="gene ID" value="PSU_v2.g18763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000768">
        <property type="term" value="P:syncytium formation by plasma membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.60">
        <property type="entry name" value="Cell-cell fusogen EFF/AFF, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3980">
        <property type="entry name" value="Cell-cell fusogen EFF/AFF, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029213">
        <property type="entry name" value="Fusogen_EFF/AFF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043076">
        <property type="entry name" value="Fusogen_EFF/AFF_dom3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37415:SF1">
        <property type="entry name" value="CELL FUSION PROTEIN AFF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37415">
        <property type="entry name" value="EFF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14884">
        <property type="entry name" value="EFF-AFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18763.t1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53153" checksum="9B0DDF7673D04E10" modified="2023-02-22" version="1">MEGQIQTTSSSDEANEERTNVTGSIMFHMSLNETACIKLETNASLPGHVGTSSILHSVEFLRLEHHYSITGKYLFGIPSISFDCKCDCAGGDPICTFEEYYHKNCTSSTAPLCYTSFLPFQSNHGCFSSQPSAVCCKMSIRPHENWMFQAITISQPSTILVLRYRIFEKLNRGWKKSVDEKIKVSLNSGGAKYDLNQEHSIEIIASGSRPHRQLEPGNYFWQLGTSANNEKPQLRGKIAINDFNETSLEKLGWFRMEGNVWTIKNGLGRMPKAQHIQVKDCKAQNYLTTLDAEQFVLEGSEDKILNYNLGSAIIDDPWVGGIEIGNRAITVNHAEGTSLLLTLKAKSQPRAVHHISQFSTFNGSIQLDKESNRFLNLTFLDTRGTLIGQVFSSESRAQMDIVFSIQTSENVEDFFKAIVSLPSTIDSRRYICIHASGDLDSQQCQWLEYKADPLNENRIRGGFIPYKFGSSSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG55</accession>
    <name>A0A914YG55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG55"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19282.t1">
        <property type="protein sequence ID" value="PSU_v2.g19282.t1"/>
        <property type="gene ID" value="PSU_v2.g19282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038010819" evidence="1">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19282.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="11733" checksum="E46850E788034D7B" modified="2023-02-22" version="1">MQHFSLFSSFIAILIVTDPSGACFGCGGFDYIGGGCCGGYGGGYGGGLGYGGYGGGYGGGYGGGYGGSFGGGYGGGYGGGYGGGIGYGMGGGICCGGGYGGFIGKRDTESNSKLIPRIEDKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGP3</accession>
    <name>A0A914YGP3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18498.t1">
        <property type="protein sequence ID" value="PSU_v2.g18498.t1"/>
        <property type="gene ID" value="PSU_v2.g18498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18498.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8146" checksum="8D595439253907B0" modified="2023-02-22" version="1">MPREVKEVKELLVLSRRKDAKSIVVKQNRDNVKFKLRCSKYLYTLVLKDKEKAGKVQSSLPTTLTIKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH35</accession>
    <name>A0A914YH35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16620.t1">
        <property type="protein sequence ID" value="PSU_v2.g16620.t1"/>
        <property type="gene ID" value="PSU_v2.g16620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="224"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="836"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16620.t1"/>
        </source>
    </evidence>
    <sequence length="867" mass="99204" checksum="ACDF39B9D1C53789" modified="2023-02-22" version="1">MARPAGKGGGGGKHVGGKLTGAGGNVEDNFVDELLAFDGEVTFKHINIIPTSKRRSTASTVASSSSAIVPIITSECLQPYAFNKAKEQDIETSVHSELNHIDFMFNIPEYNMDEEDIRFLQSTNSKRPTNDRISESQFEVACNRLEKLSVFQFWKTGSTILIAGRTFIVDDRCDVCGGDNDRRNNKLLTCQICYVSVHQECYGIPYYPASSWKCRRCAINPTLPIKCAFCPFEGGSMKFTSDNKAVHQLCAIWINGITVSQNAFLEPIDINTADTVVNIHKCSLCKQTYGAVIGCAFIDCHRKMHVTCSAIARLTMETNLQVKENKAVKKTLTEEIMERIYNRKIHCVIHSKLIRDEILSAINKVTEALEGRSENMPIDLRASPINPKYIKPEFVNFQLSEEAVKLVYRYWFVKRLRRFCSPSISRIKVIYDRMARPIRHLQNEIPAPVYQAFKNRVYLNVNSDGTIGLTANFLEDFPVLNDELEKYLTNSLGDDPEVPSIDYDNKIIIFQKQALHLHSIPNFDKDIEILFCRKRSDICRVTLDLVKRYVDPTMEFDHTADYIFDDPINPWDIIGLMFFLAVPEYIQISAFISSLWFLDFYGVFRTFNYENPDGINLKKMAMKGLHKQYPTMNDAYTDFFKMMHDANSQAIKEGRLSYINKFEEAVCYSVPSKPQYHVLQLMLNEIEAEGENKYKILLKYLMHELTMNENIDEDANAMPQCNRGKLITAAEYAKSLIILEKTFPIPNIFFLTELFGRRKINNKHAKIISLPTVGFTPMNGFRQDFIQKTLFIHPFRFDTISWIEGHKLNEEKEIKLGYKLKKEINGQTKVIKAVKETVARKRRAQPPPPTSSGSESRGPPEKLQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH61</accession>
    <name>A0A914YH61_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YH61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16641.t1">
        <property type="protein sequence ID" value="PSU_v2.g16641.t1"/>
        <property type="gene ID" value="PSU_v2.g16641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="15">
        <location>
            <begin position="53"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="250"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="345"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="350"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16641.t1"/>
        </source>
    </evidence>
    <sequence length="589" mass="62186" checksum="EDABC39C8589190B" modified="2023-02-22" version="1">MRLQNSPSDKDTEEQVDKMEDDAFLRCVEQNLLSDLTLQGIEAIGKVYMHKPNTDDKKRVVMTSDGGFQMVAEWILETDQVKVNGSSSALLKVLSEPQVDPIRTYSNDICEVFEVLGIEAVRKAIEREMNHVISFDGSYVNYRHLALLCDVMTAKGHLMAITRHGINRQEVGALMRCSFEETVDILMEAAAHAEVDPVKGVSENIMLGQLARCGTGCFDLVLDSEKCKQGMEIQSNVGYAQPIYGNDALSSPSSSSMSPAQTPWSGATPGYGGDWSPMNGMTPGASFSPAQVGSDGGYSPSYSEGWSPRPDASPAHSIGGMSPGAMSPGYGGSRSPYSYSPMSPGGGIGYSPTSPSYSVKSASYSPTSPGYSPTSPSYSPTSPGYSPTSPSYSPTSPGYSPTSPSYSPTSPGYSPTTPNYSPTSPRYSPTSPSYSPTSPSYSPTSPAGVQSYSPTSPTYSPTSPSYSPSSPAYSPTSPTYSPTSPSYSAKSPSYSPTSPSYSPSSPSYSPTSPGYSPTTPNYSPTSPNYSPSSPSYSPSSPAYSPTSPAGQSYSPTSPTYSPTSPSYSPSSPAYSPSSPQYDPYSGQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHE1</accession>
    <name>A0A914YHE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHE1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19742.t1">
        <property type="protein sequence ID" value="PSU_v2.g19742.t1"/>
        <property type="gene ID" value="PSU_v2.g19742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19742.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23461" checksum="3F19CBD11D221462" modified="2023-02-22" version="1">MFLQEQKYVNLQIEFAEATDSDERKEIDEKCKEAEKEWKKSKNEYDFIKALSAEKMDASISSTNKITDFKAMDSMQEYKNVESSDTESNEKAEFQLKLQKAKATMQSYAQNFSSLKLQMYQQNDKNIKAKYSKFVIQAEIRWKKSRKEYAILCKEANKFDSINPTVTEYQSLKSRLHEVKKQIQDSKKGIQADSWHLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHF6</accession>
    <name>A0A914YHF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHF6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1890.t1">
        <property type="protein sequence ID" value="PSU_v2.g1890.t1"/>
        <property type="gene ID" value="PSU_v2.g1890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036791420" evidence="1">
        <location>
            <begin position="16"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1890.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="24184" checksum="135569285C3C881D" modified="2023-02-22" version="1">MFFLFPFACCSSTEAVGESRETTPVKQIIVKSSEVESEVEPHRTIRVKSTAVHPIGSAPIASPEEEIKVRKIRDVEATATAPTISDTMGDNVEDEIKKVTLKEDEFNGGLAGKFLGGGDSQGGNSGGGGGGNDIGSLIGGLIGGGGGGKSGGGANPGAGGYGDNSGGYNQGGGGGGGQGGFGDIIGGLMGGGGGGGNRGNSGGGGNDIGNLIGGLIGGGGNKSGGGGGGGNYPQGGGGGQGGGGGGGFDIGNLIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHX4</accession>
    <name>A0A914YHX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHX4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19084.t1">
        <property type="protein sequence ID" value="PSU_v2.g19084.t1"/>
        <property type="gene ID" value="PSU_v2.g19084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19084.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17442" checksum="87255238FFB96D69" modified="2023-02-22" version="1">MYNPKRDNGTIRGRHLICENATYRNNGTKNNIVYWKCCFTNCKARLSTSVNGDAIFKYPNNHNHRLDGLDAQVLDAKFQLRLATTSEELKQAVENIQAKYPKYVQNKIKTSHITRSNRRRKQKLVKFTFDFDQFKAETKLGTKPSLISQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI97</accession>
    <name>A0A914YI97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17042.t1">
        <property type="protein sequence ID" value="PSU_v2.g17042.t1"/>
        <property type="gene ID" value="PSU_v2.g17042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17042.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13509" checksum="2F67E5AC15200C32" modified="2023-02-22" version="1">MSSSAMMQQQQQMNHAHHQGMPPHPMNMYPGAGGQMTPQQQMQMQAQQAAQAQGQQMMGGHGNHPAGWNGMYHPHQQQQSQQQQQHHQQQQQQQPSSIHNTISTTASKSGSSGEFSEKLGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIB3</accession>
    <name>A0A914YIB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17056.t1">
        <property type="protein sequence ID" value="PSU_v2.g17056.t1"/>
        <property type="gene ID" value="PSU_v2.g17056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17056.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8716" checksum="A43EE18274C78A16" modified="2023-02-22" version="1">MSIKCNQEDDIFTTKEKSGPITLDIPFNEALADYEYDNDVRIQIEGRYDALIIERTDEENMQVSLSARFFRYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJM5</accession>
    <name>A0A914YJM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19722.t1">
        <property type="protein sequence ID" value="PSU_v2.g19722.t1"/>
        <property type="gene ID" value="PSU_v2.g19722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF102">
        <property type="entry name" value="CYTOCHROME P450 FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19722.t1"/>
        </source>
    </evidence>
    <sequence length="450" mass="52045" checksum="0228C6577FB6FE55" modified="2023-02-22" version="1">MYQGTPDYVTTNLDFIKKVLIKEFDSFPDRWDMTRSNMVEESLRANFLTIKEGDEWRKIRQRCTPAFTSGKMKKLLPPMNHCAEELCDFLEQFAKSGKDFALKDTFSKLTMNVIGRCVFASDFNSLQSADSDVPLLHYSKKLFEVKLMSPSIILLLSFPNLCRFYQQITKRSVIQHDVDQFFIKALSGVMEQRLNDPEAKDKYTDAVQLLLNAMEEEKETKFTKEDSDIISETVEKVNKRALTRMEILAQLVIFLVAGYETTATTLHFVTYLLAQRPEVQDKVRDEVNEIFGDNTEIGYEDVSKFVYMNAVIDETLRIFPPATRLNRQCQRDIEIDGVKFVKGSTFTAPIYAIHHDPEIYENPEEFIPERFLPDEVSSRHPMAFLPFGAGPRICLGMRFAEYELRVTLAWIIKKFKFLPADEKLAWPLELDSNGGLIKSKYELKCKIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJZ2</accession>
    <name>A0A914YJZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJZ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19640.t1">
        <property type="protein sequence ID" value="PSU_v2.g19640.t1"/>
        <property type="gene ID" value="PSU_v2.g19640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19640.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12977" checksum="7D6A7BF7A7A44E73" modified="2023-02-22" version="1">MHTAYGMSKAALDAFTVNECSRLAKMGIRINNLNPGPVRTFIAERNLPEMSDEKKQVSLDKSWEYWNNCTPLGRVAEPSEMTPALLLLAGDEAGFVTGSKWVIDGGATCFANEMSLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK44</accession>
    <name>A0A914YK44_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YK44"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20713.t1">
        <property type="protein sequence ID" value="PSU_v2.g20713.t1"/>
        <property type="gene ID" value="PSU_v2.g20713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20713.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11366" checksum="1FA54374BB3F3FAE" modified="2023-02-22" version="1">MTLRIAYVTSGMGSVGTAICQSLARSGHTVVAGCAPNSPRKANWLREQREQGFDFIASEGNATDWASTSAAFAKVRAEVGEVDVLVNNSGGSRDLLFRQMTVEAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKT0</accession>
    <name>A0A914YKT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKT0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20142.t1">
        <property type="protein sequence ID" value="PSU_v2.g20142.t1"/>
        <property type="gene ID" value="PSU_v2.g20142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20142.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8380" checksum="169490FD6DEAC201" modified="2023-02-22" version="1">MYDMHIFRPDKSVPQSVLSPFRLLKNVRHSARPTIVHCSAGIGRTGSVVALELCYQQLLSENKLSVLESVKALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL61</accession>
    <name>A0A914YL61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hepatocellular carcinoma-associated antigen 59</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YL61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20280.t1">
        <property type="protein sequence ID" value="PSU_v2.g20280.t1"/>
        <property type="gene ID" value="PSU_v2.g20280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20280.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26931" checksum="F007869441E524DE" modified="2023-02-22" version="1">MADEEAPIFRKIKKRPLTSRSKTTFPSTSSAKDDDEDEVTNFEDIKEAQKIRSRKHGLNALECAVGKELARQFDDLDENPFQMRGGGQFLLTDDKKAALEAVEIEHDIKDQFKKETLLRDEHEEMKKYIAQRLNKNEDSADPEIKKYKPQNLEDEILFRAAEEIKQFTSKTNDELLSNQMLVGIPEVDLGLSSRMTNIVQTEQKKVELLKKKLPSKNDITAISPDDPSMKHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLC2</accession>
    <name>A0A914YLC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2015.t1">
        <property type="protein sequence ID" value="PSU_v2.g2015.t1"/>
        <property type="gene ID" value="PSU_v2.g2015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2015.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24264" checksum="E193C52DEA021768" modified="2023-02-22" version="1">MKSATAKSFVESLKKQSCLFGTLHIKAAAAIITFIDLFFICHLDETLYKNRASDLQYNIAFALIIYMLFMVVLAQFALHRNSGWMLLPLIITHIGFCLGSFAIYVHQIYAELIFVIQHDIHFGRLFMFVLHRIIIGFLNCYAIFILCRTYLMLRNFTEPMVVHNEVFEEKDDSEVVFFEKPSTRRHHLVASPSPFDTPSKRSVRFTNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLH0</accession>
    <name>A0A914YLH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine specific protein phosphatases domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20396.t1">
        <property type="protein sequence ID" value="PSU_v2.g20396.t1"/>
        <property type="gene ID" value="PSU_v2.g20396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF4">
        <property type="entry name" value="SERINE_THREONINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="1">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20396.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20118" checksum="7A7561FC21BE8082" modified="2023-02-22" version="1">MEDTLVWCYIEQIMHSLPLAAILNDSYLCLSGGIGPELMKVGIPGLRSIQRPPTLMSHISIATECQWACLKLPGDSDSQTDGSPMFTEEMITKFCAENKLRMIIRSRQLVAEGILNFPDQMITLWTPVSFLDSFRNASVSLRLNGENHKASIMRYNIQDREPGSLDDWRPTAGRNAMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM46</accession>
    <name>A0A914YM46_9BILA</name>
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        <submittedName>
            <fullName evidence="7">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM46"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20454.t1">
        <property type="protein sequence ID" value="PSU_v2.g20454.t1"/>
        <property type="gene ID" value="PSU_v2.g20454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
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    </dbReference>
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        <property type="term" value="F:URM1 activating enzyme activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
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    </dbReference>
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        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20454.t1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38242" checksum="DCBC09E94A579BA8" modified="2023-02-22" version="1">MSDFYKDHNLTDEEISRYGRQMITADFDVRHQEKLKNSAVLIVGCGGLGNPVALYLAGAGIGKLGLVDFDTIDISNIHRQIGFTIEDVGKKKTETLKNAILARNPNVEVEIYDTFFNKDNAMEIIKEYTVVADCSDNMPTRYTVNEACFLTHTPLAMGSAVGWAGQFTFYHINPAGPCYRCLYPNPSKNTINMSCNEKGIMGPVVGIVGNIQAIEIMKFCAFGESSYSDVMYNYDAFDGRFFNVKLRPKSPNCESCIVGLTQVNDYQMLCDRIAGQTPLSEIIPEEYRVTTFEFRESLKNDPDAVVIDVRPINEFKIAHHPRATNIPVNEFSYENGGLQTVI</sequence>
</entry>
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    <accession>A0A914YMW7</accession>
    <name>A0A914YMW7_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g20739.t1"/>
        <property type="gene ID" value="PSU_v2.g20739"/>
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    </dbReference>
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            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20739.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8485" checksum="FD64D89C9600AD8F" modified="2023-02-22" version="1">MANSPTFHGETATHLLSRQLPKIRSVVEMTMRYFKWDALPDEAQLAKAKLLLSHLKNNAKVRNWTLREGRPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMX5</accession>
    <name>A0A914YMX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transmembrane type-1 domain-containing protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
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    </organism>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g2243"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2243.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15616" checksum="2F47A4905448FD02" modified="2023-02-22" version="1">MLILAHLSKPLSFNIERLVINNATIFDTNQLDDETATEKNEIVEYVAKIVKTVNTVLSVALAFGITVSLGIVIFCIIAPIVLSCTASLTACCWCLRSDSINRSIIDLGRKLERIEAIQKFAKTEDNEMAVATFDTHITKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNM3</accession>
    <name>A0A914YNM3_9BILA</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g2461.t1"/>
        <property type="gene ID" value="PSU_v2.g2461"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2461.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11805" checksum="67C27CBC3E569996" modified="2023-02-22" version="1">MAVNISLDFLNGKDDAIKNKELQLYHFAEKYSLRDLKNVCCKKFDEILCPKNVCEIIQIAYANYFEELKLKCIEMIRSNTEEIDESELKDVPKEIYTEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPV9</accession>
    <name>A0A914YPV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPV9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g215.t1">
        <property type="protein sequence ID" value="PSU_v2.g215.t1"/>
        <property type="gene ID" value="PSU_v2.g215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g215.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="19097" checksum="8BB21C1AC97C033C" modified="2023-02-22" version="1">MFQKVDFVLTKKLSSTSIIKKINFGENLGFDLIFRNTSLVGNHFQIRNRIGDFEITKITTNYVSPEYDTYTRLFDLLYYYGDGNYKFYITANIKMKEMCVETRQIYISDSRLRLLNLYQYFKGAIDLDNLKLTYYVKKITENQTEIFIENPYDIEIEGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ72</accession>
    <name>A0A914YQ72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ72"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1951.t1">
        <property type="protein sequence ID" value="PSU_v2.g1951.t1"/>
        <property type="gene ID" value="PSU_v2.g1951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1951.t1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49831" checksum="DD3883C1699EFB66" modified="2023-02-22" version="1">MAEDDSFEVSYERSEIIRHSMIPLIDDAVEEFHKLFSEAKKKTICTNNIWKKQSKNDDYKIDAILHMEMKNFEDHDLDSLKEMLQSFCDQANIAKRESALNAERNVNLQTRLSSTEISNARLTKIVEEMETKIFNLLQKLNKEESTRISLMREYKEINEKFGNDKKKIESELGHLQDRLRHVESESLTLQTKLTESLQRENASNSALIKAQNLVDDLKAELENERIKSQTRIEKIERDGKRVYGEKEHALQKQINSMKNEISGLHEEYSKTLESHQKAAKEAIARLSKDIEELDASRMKYYNQYKALLEDLNDHKRKISHEILKQAILKLTQEYRNDQIKTSQIRKGLQATDLHGISNFGERCLDMLKSPPNTSSSEGGIYRSHRNENQPPLPSSSAAAAPPPTRYRNSGVRETAQRYDIRGHFDGNTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR30</accession>
    <name>A0A914YR30_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914YR30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19834.t1">
        <property type="protein sequence ID" value="PSU_v2.g19834.t1"/>
        <property type="gene ID" value="PSU_v2.g19834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000006">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="346"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19834.t1"/>
        </source>
    </evidence>
    <sequence length="752" mass="85031" checksum="107AE6FA7DD9E728" modified="2023-02-22" version="1">MMNADQPQVFYNLVVYIVINFRSKNLFGDDNEDLQDEGQEKVADYRSTLENFRRFIREFSAGGFNYKYREQLKKNYQLGEYNLEIAFADLKQFDEESAMKLKNSPAHYISALETAAKEVADIITKPRPESEKEVHDIQVILTLNDESTSIRKMKSTDVSKLIKISGIIVAASQVRSRAVKVTLQCRTCRHTINNVEVKTGMEGFQLPRQCNANQSGNGQRCPLDPYHIVPDKCICTDFQTLKLQETPEDVPQGEMPRHMQLYIDRYLTDRVVPGNRVTITGILSIKRLFKQKGGKANDKAMTGIRMPYIKVTGFHVEMSGTGRTHQWHFTPEEERQFHEVAKRRDVYDLITKSIASSIYGSEDIKKAIACLLFGGSRKRLPDGLTRRGDINVLLLGDPGTAKSQLLKFVEKASPIAVYTSGKGSSAAGLTAAIIRDPQSRSFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDDNKGAENIDFMPTILSRFDAIFVVKDTHDLKRDATLAKHIISVHMNADQHVSQTENDGELSLEFLKKFVAYARATCAPRLCDAAKDKLLNNYVKMRNPETHENHARSKKMPMIPITIRQLEAIIRMSEALAKMELQPFALERHVDEAIRLFRVSTLAAAESGELAGIEGFMSNSDQSTFNRIENQLRKRFAIGTYVSEDLIVNEFVKQAYEESMVKKVIGYCVRRGLMIYKYQRKMLYRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR48</accession>
    <name>A0A914YR48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR48"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2650.t1">
        <property type="protein sequence ID" value="PSU_v2.g2650.t1"/>
        <property type="gene ID" value="PSU_v2.g2650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002544">
        <property type="entry name" value="L1 CAM ADhesion molecule homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="918"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="118"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="215"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="307"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="402"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="513"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="615"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="712"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="810"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2650.t1"/>
        </source>
    </evidence>
    <sequence length="995" mass="113353" checksum="980614C055D525B5" modified="2023-02-22" version="1">MRGEYRAGDHVQINVKPRKKIVGIDPHQLYLSPTEISVRAGKRLKLMCIFGGRPVPDILWTKAEGQIPFSRIRDLNTVESDFGRSLIIDTVYPEDAGVYECRAGDLYHQITVKVTASPFWVFNPPEDVEQAEESTAELHCFASGNPTPLIQWYINGKPIYELPENDRRIILDGGHILRINALDHDIDTGVYQCNASNPLGYVFANAFVNVKAHAPRFRMPDKRIWKVVRKSTVDLSCDVEAAPDPIVRWVDVNDQIISVVPGKINLLPNHTLRIFDVNNADEGYYYCNVSNKYGLNRAYNKLEIYSPTYFAQVPSPKKITVEANESIELHCEASSDPRLTVDYHWTLNGRIINKTKPIELKQGVSTLMLNDLRGNDSGLIDCVAVTDVDVKVAGVKLLVRDIPDPPEILKLECNNRQAVLEWRKPDDHGSEITRFTIEMKTGFPPYEWQIVLEETAVTPETYQAIITLSPWVNYTFRIIAYNSYGPSEPGMPSETIHNGHHHCSTDMSVPYLNPEKVTAKGSEPDNMVIKWKPMKKYDWNAPELKYLIRYKENKPNLEWIEFLVEDSLANETIIRELPTYTEYLVQVQAVNKEGKSSLEPESIIGYSGEDVPLEAPKNFRLSKFHNFSSVEFAWNPVSPETVRGLFKGYKLVYWEDERPLFTDYIRIPVGFNEATISGLIAMKNYSAKIHVINEKYESPSNQNISFNTPEGAPSKVHNLRVHAVGANSIIVEWEPPRHTNGNIRGYFITFENSTSGEIEETYVLHRQQHYLHESLVPDSPYKVSVWAETNGGEGPKVTRLVRTWHLKDPDIPAIDIKHMSPKSILIKWKPSNGTWQMPGSSFYVNYSKANSNDWKRTEDIDLPTTSIILDNLEEETNYVLIAVAKEGPRISAALPIIYYNEGKHPVSHINRENLQSSLWFIIILCIVFIGITLFLCMCCWARTRSGKYAVKRKELESGLYSGSGVMIGNIEASEEEHKKFLEYQYGYSDKEPQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR83</accession>
    <name>A0A914YR83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YR83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2526.t1">
        <property type="protein sequence ID" value="PSU_v2.g2526.t1"/>
        <property type="gene ID" value="PSU_v2.g2526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF33">
        <property type="entry name" value="PROTEIN OPTIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2526.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="21301" checksum="EC205399ECEFBFAB" modified="2023-02-22" version="1">MQIIKKCEELEEENNIEGLSHFFFTLPRPLPLEISQNESILRARALYCFHRGEYPELYRILETTAFRGSHQKLQTMWQEAHYKEVEKQRGRPLGPVDKYRVRKKYPMPRTIWDGEQKTHCFKERTRNTLREHYLRDPYPNPNKKKELANQTGLTPMQVGNWFKNRRQRDRAAAAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRZ9</accession>
    <name>A0A914YRZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2784.t1">
        <property type="protein sequence ID" value="PSU_v2.g2784.t1"/>
        <property type="gene ID" value="PSU_v2.g2784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="30"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2784.t1"/>
        </source>
    </evidence>
    <sequence length="633" mass="70021" checksum="DE13DC8E9D7CBF64" modified="2023-02-22" version="1">MMTMDSVGAGTADGRSIHFMGRDIPRDLFMVRLFYLLWFASFGSLFPLLAVYFKQLGMTAAQAGVLLGCRPLIEFLATPFWGMFAQKFRRGKVLLMFSLSALIISTLAVGFVQPVTPYCVVLDKNDTGGECKLIIPAEEVVRGGALGYLKEATGLGRRKRDTANKIIDTIIDLSTYNGEEDMVAGMAPEYITKENVCNYEEEVYGTLVSPPHSTRVYREPAVQQAFMLLLILIALGEFFSSPALPLVDGCTLNLVSDQPQEFGRIRLFGSIGWGMAMFVMGIGLDYSDTFRNHPCPTKNTTEKNYILCFVTSTILTAMSMAVATQFRFGQEHEQHRPDEVGGLVMDTQLTEVDPAIAEKTRGKQLRTNEARGEQNEWRAALKAMMNVHFMLYLLGVVTIGFGAGNVFAFLYWYLQDLGGSPILFGMASVVNHAAEIAAFFYTFRFINKYGYVKTMYACLGANVVRFLLISWLSNPWMILPLQAVQGTVLAVNWATATSYVSLVSPPHLKNTSQQILLILYHGVGRGLGAMVGGTIITTIGARLFFALLAFITACVLAANYAGNRMLKYDGIKYSHNFDEEDITFAPQGMPMGNPESKITEAFNQTSVVNSNYGTIGPDPQDDAYDRYVSNPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS23</accession>
    <name>A0A914YS23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS23"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2809.t1">
        <property type="protein sequence ID" value="PSU_v2.g2809.t1"/>
        <property type="gene ID" value="PSU_v2.g2809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548692" evidence="1">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2809.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16705" checksum="BFF05E0E30E05805" modified="2023-02-22" version="1">MFKQLFFIFICATFALTSEGLTCTVSYNGFDDSEMPSSKIVTNVCAANIISCVSVNVKINGKHFTVSDCTDTAATILTNYLQGQEGYKNEISFDCSKNTQPIVSYNDSTISYSYKCSNYVYPIPATTEKGDASKLSCFLSTLILSIVYIAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSR1</accession>
    <name>A0A914YSR1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inositol 1,4,5-trisphosphate receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the InsP3 receptor family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g3195.t1">
        <property type="protein sequence ID" value="PSU_v2.g3195.t1"/>
        <property type="gene ID" value="PSU_v2.g3195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005220">
        <property type="term" value="F:inositol 1,4,5-trisphosphate-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000003">
        <property type="entry name" value="Protein CBR-ITR-1, isoform a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000493">
        <property type="entry name" value="InsP3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF102">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00779">
        <property type="entry name" value="INSP3RECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="13" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2313"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2345"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2373"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2443"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2491"/>
            <end position="2513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2615"/>
            <end position="2638"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="898"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1124"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3195.t1"/>
        </source>
    </evidence>
    <sequence length="2775" mass="317908" checksum="89EACEF3A34FF597" modified="2023-02-22" version="1">MFDEEMLNKLQVAADKEREQNDLEYRKMLGNVIQYGTSVQLVHVKSDKYLTMQKNSPARQERNAMRVYLDKLGNEGSWFTVEPVYKHVSIGDNVMSGERICLIPYSNVNTPTTSQIKQQLHLSQHFLHDHENAWEVNCLNEHTEWQISLFLQFDENQPGNVKSGLIASLQGDVVRLFHADQQTFLTLDEDPKSKKDVVFLRMTNRPSATDATSSRALWEIQVHNEETAYRGGAATWRRKIRFKHLATDLYLSVAKKDDKEMPSESRRPSLMIKPGETLFSGLGMGNDLRHSFEIVETDGNNTYYIVPKESKNPAKDPSLLFLLDPCAKTNTKEARVPINSFVRLRHCDTNKWIHTTDPSQKQNLYFSNKNEKGWVKVVCEDVKIDKEAFALSPVSPNEVRDLDFANDACRALHQFVQLIKSGTTVSKEPINFTTQLLIECIYFVTNVKNHVVDPLRIVDFNPTRDRQKLLREQGVLGQVFDLLRAPFLPRQGTSEMPPLLNSPQELTESRNEVFQKMFQLCYSLLRYSQVGYRKNQEFLAEKFDQIQEQIGFNLLAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRCGKFLDYLADLCVCKGEANKKIQELICNSVLSEKNRDIFMKTEMAFPNAEDGKSDIYICWEETFIRGSCKSLVSCAHSQLDEDKEMIDYYRHQLGLLAQMCQDQQYLAIDPPPERKLLNLSSELPIGLVLQCIADNRLPCDIRASFARLMLHLHVVRGSPATAVRHARLWRDIPEKVSIKHYHSNATEDSTRTRHNAPNSQHFEKVLLIVEEYLEGLKKKIVIGEPVLKDSAGYCDENRLTFEIVTLARALAQFGFYSFEDHLKLAQNLLAITDSNPKFISNQNQQLAPHTKLLRQFTKGMLNSIIQPNHGGRAPNNSSFKRPNDVPEDSARAKQSREMILQTKLIVVEILQFIMDVRRDYRITVALSWFKNKYPCNENGELDKPITITEQTVSELCNVVFQYTENELDFDGEKGQQLLRILLQMTMNDSPPLTSMALKILFRHFTQYQELIEDMKQVQLLVSNNDVDHYHQIDRDLFILKNLTEKSELWVHWDTITTTTSKPTPHPTSEDRSRSLSGEDLNIEDHIDENERAASSNSNESNTIPEHEMPPHGYIEFLTDHYPAVKQKCIGYLHEMLYSDSDKDLMASSLHSIMDKAPLMAYLIVKDILHRMLKLCFDNAKNDLMNQQLLRNMRVYEVVLEFLSIPYNKKNDTEMPALITLSHKFLRGFCRNNRENQNRLHMYVSIESDAKEGSLSVETVEEVQTLVSIFRGNADLSENVSESLIAHVVALIEHKQRNAVFLEFLQVIVTSCERETDSVQLKVVEEISKASDDVRQFYVDSASCEQLVEMMKSIDDETPMDSSHPLKFHIEIVRLCAMCTRGKNGTAELKCASFMPMDHIVRVIKHDSCLIEIKDVYLQFMLQCYIDTDIELKDASNAEYIEAIVDNILLDMRALNQMLNANREPPSALKQYICQTITEILKKFFERPYNNSQALIDIKQHQKRFNNILKQLYELQNGPLTLNKYDKNWYMVAECVKKLRKCADDMGIFPVTNGGFSPSMAPKALWQKAAHTAVFISRNQTSIIERSRRMVGGPRYSRTVDNTTNVVMCYQQLIIDFKLFLQPLQAAEGSVLVDVLHFPERLFPLGSPLRVKCEHGGVVSKLIQHCKLLLINKHENLCVRVLQTLCKMTTSTQHAFNAQGKAVRMRLLQRYFGSDAVQAPKKLKTVAVQGIDSSNSHKLDHIFDSELKPLRNISLHEIQCKLNDAGAVELVIDLIVMDASHEIFLKSCQLAKALLHEGNEEVQNAFYRLLREKKVAGKFFKAFIIKLQAAQNRLKSDMMSGSNVRAKGASNAMTPLPFGADQSIFEQIGNNLQAGTRQSSISDNALTAGEFSTLGYSGSIPDISNYQDEEKLRDTLPSEVAIIEPILRFLQLLCENHNSMLQNFLRTQGGRPDYNLVAETLMFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLITLTEFCQGPCHENQNTLAMHESNGLDIIISLVLNDIKPLADEHMELALEIKSNASKLLLAIMESRHDSENAERVLRNMAHMSGGPKQLIKAITQAFEMSTSSAYQVTKVRQELIAHHNNNVPEISVNHYDTEQKVKALGIVQQDPTKRGSQCLQNSIVDPKEVGHNVYILAHQLSRHNEELADLLNPDKVKDAGVRAALTFYKEHTAQIEIVRSDRKMERVVFPIHEICSYLTPETKQNIFVNTERDAQGSKVQDFFNGWDAMYEEMKWQKKLQNRVILSACTKRLRFWGKMAFFNAILINIIVALNYPFEKHPTGYLDLTGYIPFIYTFIIAFLIYFYSSWKDGTTFAIHSTSQLSIFTFMSCLVMLLMSHIGNTTTLYFLGVLQLLNKTIHLVSYIGNRGLIDRQWNDRLVDSTIWYHTAYLLCCLFGLLVHPFIYSLLLFDIVASEDTLRNVIRSVTRNWQSIILTGLLALILVYHFSILGYLFFQKDFRLEVEKAEVITIDNDNEVPKTCASPDQTYSFANEQKTGDGCSIAVVGEEDSDDDKYPSCDTLRMCIVTTLNWGLRNGGGIGDVLRNAHPNEPLFLWRIIYDLSFFIVVIIIVLNLIFGVIIDTFGDLRTEKNEKEDILKNTCFICGLERGRFDNKSVTFEEHNENEHNLWHYLYFIVWLQIKDETEFTGPESYVAQCIKERNRDWFPRMQAISLKEENTDSDQLDIKDLQEQMRMNQAVLKDLGKRFQDLQQILTDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVY7</accession>
    <name>A0A914YVY7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YVY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4733.t1">
        <property type="protein sequence ID" value="PSU_v2.g4733.t1"/>
        <property type="gene ID" value="PSU_v2.g4733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="433"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="643"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4733.t1"/>
        </source>
    </evidence>
    <sequence length="829" mass="93235" checksum="B8701B2123A73AD8" modified="2023-02-22" version="1">MFLFPDDNKEWSLSGKKDKQEKFGGISNSKYSNLNLNKSHKCLNDAIGAENILTSSSLGYGRKGNEKDLKEGKFWNSKLINRSTLSLHIAAYENSVENSNNENDDFGKLSKSNKKTSGKTWKNIRSIFTGQTHDSFEFPRQQENQSSKPEVMQFKASQKLLNPNQSFVDVDEMERELDALMISYGLEADIPPKAGVSKAKETPTHNSDLSLFNASSGAANSNITNSSFPTTFQLSQNNEDNFETNSAIKKSYVPPSFGGSPFGFFIGGGTLIIDSINNKPLQPFKGDKHFQSLILSILDILGRCYSTSGASVPGNDRSINETMKTNERNASLLSFGSSHNFSRSSKPGTGVPTRAPHDFVPNVRDISKIRQDDFKSAKEYKNIYDFEEPLLVHGIGYLKTIDTWEMADYPETLLQNIYDSMYPQPRQVQRVSMPVILDRYDILVCNETGTGKTAAFLIPIIAMCMQSKAENPCSEACAPFAVIIGPTRELVHQNFEQALKFSQNTGVTTAKLYGEYAVNSNIKELLNGCDLLFTTPGRLRHFFEEEFINLRYVKFLVFDEADTLLEKCFMDDIDPIIQHQNFPPKGNYQTLFFTATVGEYMIHAATRYMVKKHSVSVFSKKGATNKLCMQEFQRVPKDDRFEALKEFLDYQIAETGRDPRKFPRILIFVNSQLLCDQLTEQLRTFGFAAIGIRGNYAQDCRLAAFESFREKINPILVSTDIMAKGIDIKDVDLVLNYELPGSINSYIYRIGRVGRIKEGNTLSFVDPLLNKFIVLQLLKLLEFVNHPVSAAFDEIVEEAKRIIEEDADPSAGFDVFFGDGPYLQGPNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW07</accession>
    <name>A0A914YW07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4751.t1">
        <property type="protein sequence ID" value="PSU_v2.g4751.t1"/>
        <property type="gene ID" value="PSU_v2.g4751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4751.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18476" checksum="D55F5387F921196B" modified="2023-02-22" version="1">MMMETDNPVPPQNGDTGGEPQPTRRRTRFQEAPDEAKTNLPPPGRVNAPGVPPASLRPPSLMAPPGIRPRPLMNFQNHENENQPLNFFNAPPRNHNMQQRPNGPRPRPGLGYQGQDPPRYPPRGFPPPGGMPGVQPGGGMPFRPQANPQEKLKIWLELAGVSEEEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW56</accession>
    <name>A0A914YW56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW56"/>
    <dbReference type="WBParaSite" id="PSU_v2.g389.t1">
        <property type="protein sequence ID" value="PSU_v2.g389.t1"/>
        <property type="gene ID" value="PSU_v2.g389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g389.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10977" checksum="324D711E63F1074D" modified="2023-02-22" version="1">MISTLFTNFAKCGSPNLDETNPFSVSHDLRWDPIKLENPINCLKISTEPKMEEVERLKRCIPQSEAYAKLHEWLSVMDENVFNEFKANVKFENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWA2</accession>
    <name>A0A914YWA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g236.t1">
        <property type="protein sequence ID" value="PSU_v2.g236.t1"/>
        <property type="gene ID" value="PSU_v2.g236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF169">
        <property type="entry name" value="LRRCT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g236.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="39070" checksum="A7007F01E9E056D5" modified="2023-02-22" version="1">MGNEKEIDCVKLQQIFSDLSLGHDEEGEPYRPLHMLELDYNEFETIQWELLPANLHSITLSYNRLKNIGNISHLTKLTMLSISSNQIESISDKIFDLPLLTNLSLDKNNLKELPKNFENFKSLMCLDLSENKFDFYKSNLDEVFWNRLPKNLRTLRISRNKIGILPCILRESKIEELHANECELFHICPYLYLKKVPLKELYISENGNLNNLPFIPQKIFQPPLLKDNDIKEKTKAAFIIITDKSDYIVTKPFPQKLLKPIYEFKILEEVPSFCGCNCCGNCGNKSDENIFIEQLMVMDFGLKMRVMNEEVSPITEKKDSYDLVTILIVTIWFSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWN2</accession>
    <name>A0A914YWN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWN2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4514.t1">
        <property type="protein sequence ID" value="PSU_v2.g4514.t1"/>
        <property type="gene ID" value="PSU_v2.g4514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4514.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10965" checksum="28E7C11B63B0164D" modified="2023-02-22" version="1">MISTLFTNFAKCGSPNLDETNPFSVSHDLRWDAIKLENPINCLKISTEPKMEEVERLKRCIPQSEAYAKLHEWLTVMDENVFNEFKANVKFENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX16</accession>
    <name>A0A914YX16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX16"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4193.t1">
        <property type="protein sequence ID" value="PSU_v2.g4193.t1"/>
        <property type="gene ID" value="PSU_v2.g4193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF315">
        <property type="entry name" value="CUTICLE COLLAGEN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4193.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="32222" checksum="A34B93408580E352" modified="2023-02-22" version="1">MKTSEKRSEFQDDYEKLQEAEAFRKLAFFGTFVATTAILVGIVAVPALYGYLQRVHTVLQMEADYCKSATGTLWRQIAETQIQKGVIRADALHASGSLEEMMTRHKRQSGYDAGVTGHAGAQAPAAAPVFAPANNIAQTCSCRIGPAGEGGAPGEDGADGTDGQPGSDGNNGADAAPDAVPTAADFCFTCGDAAAGPAGNAGPKGPSGNAGTPGQAGAPGNAGGAGTPGPPGPAGNNGQPGAPGTPGPAGVLSDVPGMPGPAGPAGPAGTSGPQGPPGPNGNPGSAGAPGPAGDAGSDGSPGKPGENGDHGADGEQGNGGDCSHCPVPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXM3</accession>
    <name>A0A914YXM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g471.t1">
        <property type="protein sequence ID" value="PSU_v2.g471.t1"/>
        <property type="gene ID" value="PSU_v2.g471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g471.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23022" checksum="960F389A0164CECA" modified="2023-02-22" version="1">MKSPLLKKELTAKSDWKLFLNAAPVMSAKIDPQQIDESGTADVVMPSPSKKVVELQKTQKCSTKERDTLIPKIMPQSDKAKNIAQYGLKCGPAEYPTFGDVVSDWSTVDGVMTVEKMKEIDEKEIRRRKIIVEQQQQKDAIAAVATPPTTMKKENKDEEKIQQKKSKEGKNENVKVEEKEGKKKKKASKEKEEKRFLKMKKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXW6</accession>
    <name>A0A914YXW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXW6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5349.t1">
        <property type="protein sequence ID" value="PSU_v2.g5349.t1"/>
        <property type="gene ID" value="PSU_v2.g5349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5349.t1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55685" checksum="9F98098B89C356A1" modified="2023-02-22" version="1">MPVPLPKYKRRRKFKWTQKRLRTENRLLRQRIDYLEHESSALADRLIRGQVDLATQAENSITISHELHTLRDINSDAHRRLEEAYETIRELSSKRDGESLFNEIGIQVDDMTMIEHIHSLQEELIEAHNRKADLENTIRELKLRITELECANKRLKEAPPDDGIASIQEELIRVKMREAEASLSLKEMRQRLAELEQHWSKYANQRPSISSSNNNNNNNGTNGCSSSSIDGDGTNSPQITSPQHSPPLNQQHPAQQPQQNGTTTARGRFAKFTALIGAAAGGSSDDHDQQSIRDLEEQLMGLRIKEADAVAELKEMRQKVMELETQNHVVTNQLKRQDEELKRIREEKEVATLNEQKTATLLKEEQRKLLETQGEMKEASVMQRLKYTESLQQIADLKQNIAQLESKIAERAAAAQLRGGSIISDMDDEFSHRSGSYGDSNSIGSEEMSAFIADVTTKIPADFLTDGEITPVSVSEDSAIVEVTPTPVTAGGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYS9</accession>
    <name>A0A914YYS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMEK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4790.t1">
        <property type="protein sequence ID" value="PSU_v2.g4790.t1"/>
        <property type="gene ID" value="PSU_v2.g4790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="6">
        <location>
            <begin position="88"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="5">
        <location>
            <begin position="220"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="775"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="900"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4790.t1"/>
        </source>
    </evidence>
    <sequence length="931" mass="106291" checksum="B3C32FF93017314B" modified="2023-02-22" version="1">MDPVPANDSFDSAPTPTTTTSTTTSIENEFKEPEPHAEETKTSNETNHSEATKEVESNETSITKQESNGSTNDDNPLTNINFTRNQQNRVKLYVLHEQRSWDDKGTGHVACVRSPKKFDEWYLVVRLENEDTNVLESRITESTTYQRQQGTLIVWSESESVDLALSFQEKQGCEDVYYNICKIQASDSTVEDDQGSDSGESGGWGQTISLPPCDMTHVTELENLISSSMSSNNTREVISNSLLRGDYLAKYCDMFEMAEDLEDQNTLSSMAAIAKDMFMLNSQALLNELISERYFRHFIGMLEYDNSVRKPKKHRQFLFDRAKFKEVLPITSQDLKDKISETFRLQYLHDICLPAPSIFEENLLSTLSSTIFFNRIDIVSKLMSDKQLIKQLFNELKDKTTPPQRQKDLAGFLKEFVTCAQALQPSANQGREQFFNMMMENDVYQILDPCLSSSIHLTQSICVELLSLIVDFSLGPFRQFLMKQSAPDDESLLINKMFRYLVYDRDAEFTNARNMAEIVRIILDPDAQPRNDCETFFQFFYEHCMPILIKPITDCIANGKLIRDDFYTSRQFCMILTMLIFCVKNHTQLMRSYIIKSDLLTYVCVFLKSRHHLTIIKVCRLMRRILDLRDEVYHRHIRDKRLFAPIVEAFNANGHRYNLLNSTFLDLFEYIQHDNVVSLIDYIGSEHMSELINHDYVKTFELFNRKYEKRKDDEVKRSEQQQQRSSSMPSPKHLPERLLSQFEREKRSEDDEVFFNGDDDDSIKQENGIMEDEPSSTATNSSSSPSKVNVVSPMRKSGAEMNFPSLGKRKSNDDEGVASIFGGSAKTPSINKPGKITIKIGGTSSQGSSSSSSDAPMNEEVADAPIKTILNPRYRKSSLVTYDSSDSDSDEEGDNKNNIKSKSAPASVSVSPVSQSPPKKKIKVLHYSPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYW4</accession>
    <name>A0A914YYW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYW4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3237.t1">
        <property type="protein sequence ID" value="PSU_v2.g3237.t1"/>
        <property type="gene ID" value="PSU_v2.g3237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3237.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17816" checksum="4B1B5AB373B0EE19" modified="2023-02-22" version="1">MKLKPDELLFISQVFNDFIKSKYPVPDFYRQRLKEYDPIIVKFARCRSFKSARKLSHHVPLNVFASICRWGSKFYNEEEEAATKVMKKKSKSKPKPNQPTHNITENEDVKPSRSEILLSLPPELDSTQQTTQQQLIPNIKQEETSSFTIGNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZD6</accession>
    <name>A0A914YZD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine hydroxymethyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g340.t1">
        <property type="protein sequence ID" value="PSU_v2.g340.t1"/>
        <property type="gene ID" value="PSU_v2.g340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF50">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g340.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10100" checksum="F21D088ED0139C2C" modified="2023-02-22" version="1">MMLINLSTKPYTGQEASDALADAYITVNKNSVPNDPRSPMVTSGIRIGTPAVTTRGFTVEDCEQLAHYLCDVLDAYEAGTLDKVKHEIREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0D0</accession>
    <name>A0A914Z0D0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z0D0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5337.t1">
        <property type="protein sequence ID" value="PSU_v2.g5337.t1"/>
        <property type="gene ID" value="PSU_v2.g5337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="410"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5337.t1"/>
        </source>
    </evidence>
    <sequence length="555" mass="64244" checksum="C99DEAEA616FA7C8" modified="2023-02-22" version="1">MRIIYWSIIGFIYILQVNGDLFTSIADLQRLLVVEKNIPELINSYIATENDRLAELKNFVVKYKDNNDDLHKNMNVVTNPINAFRMIKRLTNAWKELEEKMRNDHAEEFINNVTNSDMNVFPKDEDLAGAAIGILRLQDTYRLDTHELANGYVRENKISRPLSAHDCFEIGRMAYNVEDYYHTLLWMGEALERIKKEDPATAAESDILEYYAFALYKQDNVKRALLATERLNEIHPTHSRAKGNIKWYEDQLAAEGVKRSEFRKKVPPLSNIRPVDNFESTERSVYEALCRKEIPVSIKETSKLYCYYKMDRPYLRYAPFKIEILRFNPLAVLFKSVISDKEVETIQSLAKPKLARATVQNSETGQLETASYRISKKEFILSAWLKATEDEVVERVNRRLELMTNLEMETAEELQIANYGIGGHYDPHFDFARKEETKAFSDLGTGNRIATVLFYMTQPEMGGGTVFTELKTTVMPSKNDALFWYNLYRSGEGDMRTRHAACPVLLGVKWVSNKWIHEAGQEFRRPCGLKLSTYERYVGDLGGPEPRYNLNLSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0M3</accession>
    <name>A0A914Z0M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0M3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6282.t1">
        <property type="protein sequence ID" value="PSU_v2.g6282.t1"/>
        <property type="gene ID" value="PSU_v2.g6282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6282.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11806" checksum="A852FCE0607685AD" modified="2023-02-22" version="1">MRRSQRLRFFAVGVASEAGVPQYREFDILTGRYIRPDVLVKITPSICKSIKQITHNAVTCMDRLESPTKECVDRITNALEEVQQIDNLYGKIDEQKTKSVFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1B9</accession>
    <name>A0A914Z1B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1B9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5684.t1">
        <property type="protein sequence ID" value="PSU_v2.g5684.t1"/>
        <property type="gene ID" value="PSU_v2.g5684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="179"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="452"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5684.t1"/>
        </source>
    </evidence>
    <sequence length="521" mass="58010" checksum="24CA2EE029A702B8" modified="2023-02-22" version="1">MHRRRSRSRSPIQNNQNRRDRRTKEKRPIDPHSDKMVYLSNLPFELKWNELKDLIRQKAGESAFVEFLEDRDGKPKGCAVLDFDNRAAAQRCVDAFHRMDIGGRSITAKEIRDPMGFFRHILKNEGIDFIANRNLIPGRTGYRQRREREDDIGGVSENETYGLSPTFLAQLNIKPPLVNRVFVTNIPYNCGVGKLYDIFSLAGRITWFDLQLDSEGKTKGMAIIQFSHPIEAVQAISMLNNQRLFDRTLSVKMDRFDKEIPRQDGELPAGLRAIGMGLGSGGQPLANVASVISSLTGVNGGAVSVPQPNMQPFIQPPINGNNSFTNQSFSQASLPAPTSALNGSFVNNSMNMGLAGGDAAPMGYVQPQAPLPQNSQPPAAYSGNSFFNNNSTPQPVNNGPPLNSTMNTSGFNSTPSNNMYPKMSPQVNYGQQQQPPQQQQQNKPYYDTQPSRVILIKNLPMDYTWQIVHDRVQKFGEVENVEIISPGVAKVRYVRIPDAERTKAQLSGTTVEGRIIAIEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Q0</accession>
    <name>A0A914Z1Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Q0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6038.t1">
        <property type="protein sequence ID" value="PSU_v2.g6038.t1"/>
        <property type="gene ID" value="PSU_v2.g6038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6038.t1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46331" checksum="9ADB875746D7A735" modified="2023-02-22" version="1">MLFFAWSFIQSAVNYARRQRLIAILQKHLSAPFSYETGIICRRIPKITSFPGPSTSTSSSTFLIKAPSEPFLNYETSDTVILYRTEESEIVAVPKPDSLKIHEWTLFTTENIPRKSIFIPPNVPRVSFIAVIIPSPNFNNKTDGFTSTSTETLTEGLNDTDNDENGDNLLNIDAIETLDAINETDTGLLSSLLSLYANQIAFRRRKPNEILYETDLNNFFNIIFQWSESALYEFNGKGIVKEIHSVQLPNLTSERALLTLSPSNSTFSQISSNTLPATFSSSPYKQQQPYTLLEYLYFKDLFGEEFPTSWRTINVKNNYYFHNSVLKNGYSFYRSDSALNRAISPTASFYRKAVFPSSGECAITNLPTHLPPLPQPRSPSPSIPAYIRQLREHEKFDRRRTVSLNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2Z5</accession>
    <name>A0A914Z2Z5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2Z5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4628.t1">
        <property type="protein sequence ID" value="PSU_v2.g4628.t1"/>
        <property type="gene ID" value="PSU_v2.g4628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4628.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24518" checksum="09C336D5C38CD1AF" modified="2023-02-22" version="1">MFSFQLKTPDSISVADSGIDCTLLEEINRQAAVVLNSPLISRKTRDDPEDPLPTNNLTTAKTNFSYVLSKPHGSFDLTLQTNNTSKASTTSSSPQQAASEPPRSPPPLTPSSSSDLTTVFTENHAPNSSHLGILLLSNARRKLQLEEERIEFEKEKQREKEKRKSKKLFFRLTKRVREKGGGMVDIPQSASDSALKRIDEDEISTSGHSSFFGQHRNTSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3F6</accession>
    <name>A0A914Z3F6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid synthase</fullName>
            <ecNumber evidence="1">2.3.1.85</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.85" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z3F6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6893.t1">
        <property type="protein sequence ID" value="PSU_v2.g6893.t1"/>
        <property type="gene ID" value="PSU_v2.g6893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6893.t1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45165" checksum="6AF1E0CD099D0F19" modified="2023-02-22" version="1">MRLPFYMVPNFFVFMEKLPVLAASSKIDRKALPNVDLDKDVVEAEALAQTETEIKLAKIWAEILQQKTLDIQESFFDLGGHSLMAARLLAKVTSEFGVDLTMRDLFSSPTVYAMARVLDGADRKSPDQNVDLDYEVNTHDIKDNVMDLHLRAFWRSTEYRNRFFRSTILLTGVTGYLGSHLLSRLLTSSQARIVCIVRESSCETVQSRVENTLKKHGLLTKNTKENLNERVRAVAADVALFQFGLSDEHYHFLTYDIDVVIHAAAYVNLIYPYHALHGINVLGTRNVLDFCHTNKVKPLHYISTDAVIPAGLKDVDEDFRVEHVKEKLQDGYGQSKYVAEQLVKLSQLRGLPSIIYRLGNQAASTTAGFWNDQDFTYLLLQSVIHTVSSILQNLKFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3L6</accession>
    <name>A0A914Z3L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3L6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6950.t1">
        <property type="protein sequence ID" value="PSU_v2.g6950.t1"/>
        <property type="gene ID" value="PSU_v2.g6950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6950.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22401" checksum="F37727611524C8E8" modified="2023-02-22" version="1">MTCNPNWKEILENLLEGQTPADRPDLVARVFKQKKDYLINLISKEGYFGKCKAHVYTIEFQKRGLPHAHILVTLEADYKMRTAEVINRYISAQLPDPELYPNLHDLVVKHMIHGPCGPRCMKDGKCSKHFPHEFQEETSLDEDGYPSYARPDNGIKVTKSSGFVVDNRYVVPHCPNLLLELNCHINVEVVMILQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3S2</accession>
    <name>A0A914Z3S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3S2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7349.t1">
        <property type="protein sequence ID" value="PSU_v2.g7349.t1"/>
        <property type="gene ID" value="PSU_v2.g7349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7349.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26634" checksum="156E50AB4F1E4A9B" modified="2023-02-22" version="1">MPQNEHIELHRKRFGRRLDHEERLRKKLARAAHDRSRIAKTLRGGKAKLYHKKRYSEKVQMRKTIKEHEEKQQKSTVKEPEQGAVPAYLLDRQKQTTGAVLSNAIKQKRKEKAGKYNVPLPKVKVVSDAEAFRVVKTGKSRRKGWKRMVTKATFVGENFTRKPAKFERFIRPMGLRVKKAHVTHPELQTTFCLPIVSVKKNPSSAMYTSLGVITKGTVIEVNISELGMVTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3Z4</accession>
    <name>A0A914Z3Z4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3Z4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7074.t1">
        <property type="protein sequence ID" value="PSU_v2.g7074.t1"/>
        <property type="gene ID" value="PSU_v2.g7074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7074.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9514" checksum="B562DDDEA9F590B3" modified="2023-02-22" version="1">MIRFQIPKTDFLKTETNRLLAGAASAADKEVIKNLEFEAQKLRTANTELNDRYTKEASDCDHMRTLLELEEDKVENLKRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z459</accession>
    <name>A0A914Z459_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z459"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6789.t1">
        <property type="protein sequence ID" value="PSU_v2.g6789.t1"/>
        <property type="gene ID" value="PSU_v2.g6789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6789.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22627" checksum="9E0B6DA0B1B6F80C" modified="2023-02-22" version="1">MHCPLCNAQISHPALTALLKPLESLLQDVSEKAKLRLEYDGLLNSPAITSETSEFYQNPVTFAMERYVYVLCSKCGKAYFGGEASCQEALESSTTFNPEELLCGGCSDIAGAEICGRHGVEYLEYKCRFCCSVAVYFCFASTHFCAGCHADFQRLMPMPKASLSQCPVGPRCSQLEGEECPLKVKHPPTGEEFSLGCGICRNIRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4P3</accession>
    <name>A0A914Z4P3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4P3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6953.t1">
        <property type="protein sequence ID" value="PSU_v2.g6953.t1"/>
        <property type="gene ID" value="PSU_v2.g6953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6953.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12045" checksum="8BDEEA04E2F0326A" modified="2023-02-22" version="1">METLDREDAAYLRLGGNGGGSGPNSSEQFYHLAGDKSDCTLPDKPDNTGGIRTTRFARSDEHSNNNLGSSNADESQSVATDARGWDIFRLLPPKNDNLAKGKGFKTKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z548</accession>
    <name>A0A914Z548_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z548"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7091.t1">
        <property type="protein sequence ID" value="PSU_v2.g7091.t1"/>
        <property type="gene ID" value="PSU_v2.g7091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7091.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23540" checksum="361507CB1C7D59D8" modified="2023-02-22" version="1">MIFVKDLTNGRNKRNCLLLRYNNALESKMFTISEENTELTETVEKLQKLAEKNVPQKPIETPLNVMSESFVTDYNGLQDKVDELNEDKITLEAKVREMETFMKEMVQKLEELESVNAELTEALSYVNNKKQQLLEENKYMAESVTTMQMQLDTLGTPVLDQKERGNSLFIEFEAENQMTLKQKAEMEQEVCFQVFLFYIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z549</accession>
    <name>A0A914Z549_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z549"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7023.t1">
        <property type="protein sequence ID" value="PSU_v2.g7023.t1"/>
        <property type="gene ID" value="PSU_v2.g7023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7023.t1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41648" checksum="57F8058353B3EBFC" modified="2023-02-22" version="1">MSSTTTTTPSIMSSSLFTPRFVPHRLVWKNDDDVCYECIDRNSYASVIVRLRKFETSNVELYKANIAKAEKEAIKHECIANLTEIIIDDANKISITVSENPRGITFIKYVETYGSAKEFPAALQQILTNISDLFQILNSTGKDFCAIPLQHLIIATNDGKIESMKVRRPFLSALTKRSLLAPYNRYSNCNPSFVDITSIAFYALTQKNFFEFENVEEALNILEPLQRTIIFEILISTNFEEVSNCIQRMKSSDTEIVNQYDCDEISETSSFGICDDDEEEDKQFDEGVSSDSDYDIVNHSKSTKDDDDDEVRTAIGKEDVDEILTAIDKDEFETQTAIEDDETQTAVEDDEDEIRTAIDESDEKNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5V9</accession>
    <name>A0A914Z5V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5V9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7330.t1">
        <property type="protein sequence ID" value="PSU_v2.g7330.t1"/>
        <property type="gene ID" value="PSU_v2.g7330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7330.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="33960" checksum="A11430DA5592C812" modified="2023-02-22" version="1">MSSAKLSTALAVAISTGVIITCTIVVSFLINDINSLYDDILSDLDEIQNTNRDAWNSMMNMQQRTSLGNGDIRNLFEFRRIKRATERAPPKCNCDANRGKSCPKGPPGPAGERGESGEAGEPGTPGLPGATGMTVLLDLPHAGCIRCPAGGPGPRGPPGQPGPQGLAGPRGNPGRNGRDGYPGPPGAYGDLGSAGSAGKPGPDGRPGQEGTRWIPSPGAKGRRGTPGYPGAQGDRGQNGGPGNPGEQGPPGQPGYRGNPGRPGGAGPPGNSGIPAPNGEYCPCPTRSGAVPAPRGPSIDVSSVPSGAEYSSSGSSNPGNYAPDSSPSPSEKEYQRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z610</accession>
    <name>A0A914Z610_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z610"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8114.t1">
        <property type="protein sequence ID" value="PSU_v2.g8114.t1"/>
        <property type="gene ID" value="PSU_v2.g8114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF355">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8114.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30490" checksum="41284E534C3787D8" modified="2023-02-22" version="1">MHWKIVRTAIKVIENKQSSVKGKGGNPDATTLSSKRRQIPAYAILETTKAEFIALKHMSHIRFGKDELNYIMDLKRINHDNLTNFIGICYNDGDKFYILHNLVERASLEDYVFDIDFKLDETFRSAFLRDILKGLAYLHKSPVGYHGLLSLANCLIDANWVLKLTNFGVTKLLHNLIESNNLKVIENIPFELYYAIAPEHLQGVALGKSYPRGDHYGDLYSFGIILYQILFRIGPYEKTTYGHKGIFDLGNCLPRQKILRFFDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7G8</accession>
    <name>A0A914Z7G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DadA oxidoreductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7G8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g827.t1">
        <property type="protein sequence ID" value="PSU_v2.g827.t1"/>
        <property type="gene ID" value="PSU_v2.g827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008718">
        <property type="term" value="F:D-amino-acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055130">
        <property type="term" value="P:D-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF280">
        <property type="entry name" value="D-AMINO ACID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g827.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19490" checksum="D8875CF3279A24A2" modified="2023-02-22" version="1">MAEELGVKFHYNVDIKGFQLNSGKIVAVETNKGTFTADRYVAALGSFTPHLVKGLGLNVPIYPVKGYSITIPIIDESRAPVSTILDETYKIAITRLGDRIRVGGMAEVTDYATFWSGLRPMTPDSTPIIGATKYDNLYINAGHGTLGWTMSAGSARVMADLISGKKPDIDTSDLGLSRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7P3</accession>
    <name>A0A914Z7P3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7P3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8345.t1">
        <property type="protein sequence ID" value="PSU_v2.g8345.t1"/>
        <property type="gene ID" value="PSU_v2.g8345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8345.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29782" checksum="D65B5C40101C61B8" modified="2023-02-22" version="1">MANRLQREGAVVRGRNPQNLIEKIIKTRIYESMYWKEQCFGLATENVIDKGAELRYIGGVYGGNFKATPFLCLTLKLLQLQPEKEIIVEFIRQDDFKYIRALGAYYIRLTFTPVEIYKYLEPLYNDFRKLRYMNKEGRFELIHMDEFIDNLMRNEHYLDIKLPQIPRRQALEEIDQLDLYSSVLDAELDKIDVSDSDGDDEKRKKPKPRLVSRKRSRSRSRSPKRRSGKKTEKDEIAEANALRAKLGLAPLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7R2</accession>
    <name>A0A914Z7R2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7R2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7936.t1">
        <property type="protein sequence ID" value="PSU_v2.g7936.t1"/>
        <property type="gene ID" value="PSU_v2.g7936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7936.t1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46446" checksum="F47EDF9F1E7A0421" modified="2023-02-22" version="1">MHDNMASTEKESAMVETFANAEKPEGMLSRYSIKSIPSEELKNGKMVAFDEVIKTFVNIRLDTVPYSSEINYRKIVRELELCVKLFHKNIINILNLFSPQQSSASFSSFFIVYNYMDYTLSHLIETRDWLQQRNKSTGAERLSFIAFQLFCAVDYLHKAGICHRDLRPETIMVNKKCRLKIAQLGNARHVSEIAELPHETDSYGYYAPEIFYEVKTQKNNWIKAKKNLDEFKPQMPPNPSSDVWSLGIILYEIVSGEKLFPDLNDKTDNPYEQVVKVAKDLPIKINAECFPSSDHSKLKPHHGHALLQRLIATAPETRITVKQALNVEYVRWVRMEGDIGVPPPQCITVGLDKVRFSLNDWKDNLFQMIKDYERTKDINKWEPKLPPEDSFPEPTQKKPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7U6</accession>
    <name>A0A914Z7U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7U6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8402.t1">
        <property type="protein sequence ID" value="PSU_v2.g8402.t1"/>
        <property type="gene ID" value="PSU_v2.g8402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000027">
        <property type="entry name" value="CarboxyPeptidase D family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF73">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="10">
        <location>
            <begin position="11"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8402.t1"/>
        </source>
    </evidence>
    <sequence length="421" mass="48009" checksum="2DFFA1831FF42A5D" modified="2023-02-22" version="1">MKELSEEEVAKHHNYANMTLYLEKLVQEFPTLCTLNSIGKSVEGRELWVLVISKDPRHHIPGKPEFKYVANMHGNEVFGREALLRLAKLLLINYGSNEYLTKLVDTTRIHIMPSMNPDGYERAQEGDAMTGPGRDNANGIDLNRNFPRRKAGAPVQVQPETLRIMEWSKSVPFVLSANLHGGTNIVNYPFDDFQHGRSRTGDHDVFVTLAYSYARAHLNMYKRGMRCAEKGGEDFIDPPKGITNGAEWYEVSGGMQDWMYLVPGCFEITIETNCAKFPWAKELPQFWNDHKYALIRYIDLIHHTIHGFILDEQTGKGIPNATISINSRGKILKSYEYGDFWRLVTPGTYEVTVDHLHYYPVTKSVTITTDSPSYLLNVTLTPHSYQQPSTNSHIASPINNSPKITYINLIIVLTLFYFNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z891</accession>
    <name>A0A914Z891_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Costars domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z891"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8113.t1">
        <property type="protein sequence ID" value="PSU_v2.g8113.t1"/>
        <property type="gene ID" value="PSU_v2.g8113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1540">
        <property type="entry name" value="Costar domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026111">
        <property type="entry name" value="Abra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027817">
        <property type="entry name" value="Costars_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038095">
        <property type="entry name" value="Costars_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22739:SF7">
        <property type="entry name" value="EG:152A3.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22739">
        <property type="entry name" value="STRIATED MUSCLE ACTIVATOR OF RHO-DEPENDENT SIGNALING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14705">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01283">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Costars" evidence="1">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8113.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21769" checksum="A2FAE6F4A21DD196" modified="2023-02-22" version="1">MAFQSTSNQINQASEFRSLTWPKLTFPRRPMVSSVGKHISKFNEAEKKNEKELRTNPFSKTYEIPKFDKNAADYARPSPGSKTEARAKKAGVYMTREIVFLCDLISQSADGEPPNQTIKFGPLFYSYSLYSSQLVGMLVRARKYGLVDFEGEMLYQGQDDDKIIRLLKPIEEIRRIVRFSGDPVHCVAIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8B5</accession>
    <name>A0A914Z8B5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8B5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8139.t1">
        <property type="protein sequence ID" value="PSU_v2.g8139.t1"/>
        <property type="gene ID" value="PSU_v2.g8139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000518">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="63"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8139.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21829" checksum="6B8298C4DE3499A3" modified="2023-02-22" version="1">MMITTKGKTNTYTIDAATFKSVPDLINHYVDKKEPVNVQNSSTPAYLKTAIARQEWELSHDDIAQIKKIGEGAFGEVWLGKLKIKAGRKVDVAIKVAKTEQMTKEKIKELMKEARLMRNFEHPNVVKLYGVAVKQEPLMIVMELIDGGALDEYLKKNRGKVAVSEKVDQMCMGAAWGVEYLHFKLCIHRGKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA22</accession>
    <name>A0A914ZA22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8636.t1">
        <property type="protein sequence ID" value="PSU_v2.g8636.t1"/>
        <property type="gene ID" value="PSU_v2.g8636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8636.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11588" checksum="7B0C84A78ADEEA0C" modified="2023-02-22" version="1">MYFNKVALPQMEYVEDFADFLIDAELNDLPVLKRACERYLCGELNGKKDLLTSLLLDLLFLAMLFQLPVMKSMTLTELTERYDEIRDINELLKQEEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDL5</accession>
    <name>A0A914ZDL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDL5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9774.t1">
        <property type="protein sequence ID" value="PSU_v2.g9774.t1"/>
        <property type="gene ID" value="PSU_v2.g9774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9774.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22787" checksum="B37391CF6BAF54C7" modified="2023-02-22" version="1">MVIHASSDIQKGDEIWHSYISPLTDFMDRKETFNCWKFKCDCKLCEIEANDKNYLKRSEIAKQFNEFAEANKESPHIVIVKGESVLKEIRETYDEKNEFKIQLISVHMILSGIYFDIDNVIKSIEYLEAAISLMDNLIKYAFNIAQITVNLAHCYLLLGNYPKVKEMVQKAFKFSFCIDMDHFKMCFPEIANDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDN5</accession>
    <name>A0A914ZDN5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZDN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8380.t1">
        <property type="protein sequence ID" value="PSU_v2.g8380.t1"/>
        <property type="gene ID" value="PSU_v2.g8380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001641">
        <property type="entry name" value="Myoblast growth factor receptor egl-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001689">
        <property type="entry name" value="Myoblast growth factor receptor egl-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF550">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="341"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="444"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="678"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="991"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="685"/>
            <end position="692"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="851"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="865"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8380.t1"/>
        </source>
    </evidence>
    <sequence length="1061" mass="121094" checksum="96AD7C1B9B1FF1FB" modified="2023-02-22" version="1">MHTMHRYQENERNMTLEIRKVELGDKGEWRCRVWNNEGSITRNFTLHIIDYCDYFLFSNITVSNLPLECICQWKILKFTKEGVNFSRVTDEICKQFKKDNNDILLHRRPACIGRPCTPTDFSEMSSDVNATLLYKDIESLENGVNPFSQSSLNSVDDLLPASSPMFDISPRAVPRISNGPKILDPIKMFDYLAESGVPDVENLLPGLHSHADLQYLKYKLRNWDPNLDIDAKIQDMSYIMKNRPSTIELKNGVNEADYNSVEPEEQIKTKSSDIPQIPQKPQQEPQQQQSLPIIPEEKVAEEEKKETTLTPTAATVPFEMVETTTRSGYWPGPRKLTNLAPYFRQASLHGSAPIISPAGRTVKLSCRASGQPQPHVTWHKNNIELSDKSERNTGAPYKFRKFSLEMQDAVESDSGMYHCEVFNKHGTIRRDFEVTIVDRARSKPIIVPNVLMNETVNVNSTVNFTCKVISDSLPYFSWAKLLMINGSYINYTDPAEPKFNILDTYFMPRAKVSRDHRVTVLTIINVTLDDQGLYACIAGNSLGLTMANATLTVNEFRPMTLPTEQLTPPTDFQYVLFIALIFFAVAILAAVATYIVYQRRQSKNRIQNLDKMGVLKKVVITRKVPKDGEFWPDLASSYAITIESVIRKQDHENSGDTSFSPQYEVPTDDRWEIDRSKLTLTNILGEGAFGEVWQAILQKEVEGGNYEEEPVAVKKLKQTAQDKELIILVGEMQIFKSIGEHRNVLKLIGCSTGLGPLYVVLELCRHGNLRSFLQSHRRIDEEPIYNYSENSESSVNYVQPHQSSSVILEGESQPGIRKLMLRDLIRFATEISRGMEFLAAKKIIHRDLAARNVLVAENYTMKISDFGLSRNVIHNDYYRKHGNGNLPIKWMAPESLDEDRHIYTTYSDVWSYGVIVWEIMTLGEQPYRNIPMGCLYEKLKSGYRMEAPPTCPEEISSVMQRCWRDIPEERPSFKTIGDYFDKIIKGCDTYKEETHSEPSPQQSDESDNGDEGLIYDIISPLQPRKRPMLVPDMESFEDFVEKSNINSIENAEDSPLLGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XPV2</accession>
    <name>A0A914XPV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XPV2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10045.t1">
        <property type="protein sequence ID" value="PSU_v2.g10045.t1"/>
        <property type="gene ID" value="PSU_v2.g10045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03714">
        <property type="entry name" value="RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037309610" evidence="1">
        <location>
            <begin position="20"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="213"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10045.t1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61897" checksum="E7C844D5277976B8" modified="2023-02-22" version="1">MHSSLFAALNLVAISDAEGVDEADRANFRARSMRVISMLIQQITTIRRSMAVDSLGVDKKVIGAFGGRALDLKEADNPSREGQKVHWLFAKDMEDDLLAEIKKKEKEWEKKKLVSFFKPFNQWDIKNDITYPLLPFYMPDPVWEEISAPMSAGRLRHFASNWSKITNDPFVLEAIKGYKLPFREGKKPKQPRNYYCRDATEPEIKAEVISLLEKDAIEKGETAQWLSTVFSVPKKDGGMRPVINLRGLNEFMVTPHFKMESLLLLKDLIGKDYYMVKLDLKDAYFGIPIAPEHRSYLAFKVFGKIYQFKALPFGLAPAPSVYTRVIKPVAAFFRARGILLIVYLDDWLFMAESKKKLLADVKFVRTNFTALGLMINEAKSQLIPSKRIEFLGLEVDSSKMTISLPSEKQHRISILAQQILTTPVTSAALLAKLCGLLASVKLAIDYSSIKARYLQSMLKLVDNGRDLEQQKIALTAEAKEEARFWGSKNSIAFVRGLKPPPVSMAIRTDASLEGWGFHCGDSSSGGRWNKAEKKLHINALELKAVLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTM6</accession>
    <name>A0A914XTM6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 5"/>
    <dbReference type="AlphaFoldDB" id="A0A914XTM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10323.t1">
        <property type="protein sequence ID" value="PSU_v2.g10323.t1"/>
        <property type="gene ID" value="PSU_v2.g10323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="6">
        <location>
            <begin position="225"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10323.t1"/>
        </source>
    </evidence>
    <sequence length="487" mass="56346" checksum="66319C9E15CB81CE" modified="2023-02-22" version="1">MGRPISHYYINSSHNSYLIGCRCIELDVWETPSGPVITHGPIALQKINFVPLEEICEAIAEAAFKTSDFPVILSIENHCSVEQQKVISQIFVKVFGDLLQKRALPKYPISDPNGNYPPPIALKRKILIKGTQNKLGDKKAVIQNSQETFINRSKSRLAELTVERLKDAKVLGKDDEKDKLLDEKHADCPERKCERNMSSRYDSPMELGDSLRDLVNYLEGAPKYKENDPFYWMYSGGEEKIDKLIRKNSTKFIHHTIKHFIRVYPDISRVCSSNYIPMYFWTAGCQMLALNFQTNGLPMQMNDTLFEENGRSGYVLKDDCLTNPHYNMTVYDPQYLVANRVEIKVISGQFLELLNLTSLNNHCKSSSSQQHPQQHLKTQVYVELYDLPQDTLRNTFCTGYSTSQNYNTIYPGNKFEFKKVIKPRHAMIHLRIINENKEEIGQRFLPVHLMRQGYRHITIRNRANRVMGPASLFIHCNQKFENNLWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUA4</accession>
    <name>A0A914XUA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11532.t1">
        <property type="protein sequence ID" value="PSU_v2.g11532.t1"/>
        <property type="gene ID" value="PSU_v2.g11532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11532.t1"/>
        </source>
    </evidence>
    <sequence length="833" mass="93465" checksum="28351C2D7D8F12C6" modified="2023-02-22" version="1">MPAFTNYSLEELRFAFQKAVDIKETYKLSYNQQTGFFTVDWKPKKSGRFRIDCMIDGFKLGSTTFIEVNERRTPSLSPRSIFATAEKDLAEKEAVKQKKAFCDPLSPFMGVRIRAHPSLSAPAIGTICRGCSITWDEWIKNSDGTWLKLTEEARVLFCDKSNGQAGWCLQYHKAFEKTLLIVDERDLIESNSKNEKETAAENISIKPLLKSPRRILPSLPPKPSKTFKSELTEDADILTINRASTQVSSTTTSCSHHEALSPRLMDCCKSVFAALIWHERLSGDLMTCANHLKSSPQIEQLFYDLQNPALPSCFSQIIKLYRSSIQCVLEIVEQHLILPSPPSMKQLASRHMFLPSDEICELCHELHPKPITVHMREKHPGCGGPCGGHGYNSIGNYTTGWTGLCGDGGKSNAVWYLMCPNCRTIYLNKAAEGKKNQKDDTNDWTKFRQKAVNKQFCAETVLKENALFLLDLRPCEDATRLPIRLTPKKIAHTYKINLYPQGSAIPQKEPSTDDALLVDTDFVSNNIGLSPLHQMSHQSDPGKQPTDLSVQDATDPFSLSASANLFRRPQPLPPLLPQRLTSLNGLNELLRHPVLLFCVETHNLQSLRRHFYRSISRATKFAYAFRVWNWLLKLVTSETIVTDIVWNYLTTLGSYSSYNHWLNMDLKFATKLKLLPHPWRLCYLSGTDVAGAMIDEMHSFLGTLAVILQSPGVDMSLKCLCFKAWTFHLTIHEQNLLITMCNILSAVGAVLSDSASDVSTLFDESALSILAGFGPSKNLTSATFQPSSKLSPKKPIILRQLSSSHLHAINQVSIKQHENLSNILKIGPSSRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV24</accession>
    <name>A0A914XV24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZZ-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XV24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11087.t1">
        <property type="protein sequence ID" value="PSU_v2.g11087.t1"/>
        <property type="gene ID" value="PSU_v2.g11087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="10">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="10">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11087.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25834" checksum="9F99CC5EA93AB138" modified="2023-02-22" version="1">MSRYFDEYKPFHNIYCNGCGKDPIYGNRYKCQKCYDLHLCEKCFTNNKYGEEYESQHNETHAMQLFMSVLDEKSITHHILKCNGCNSEKYPGKRYCCNMCQNYNLCQRCFDDSRYTANGIIVKHNSKHEMTVFEFEADEHNDNDTWKAMTIKMQNYFGTQLGRKDWITYNVDVPEEWKNLGKNIGYAIYGPPFIIPSKSAIGGSKEKICEFGYSSKVIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVG6</accession>
    <name>A0A914XVG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVG6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10528.t1">
        <property type="protein sequence ID" value="PSU_v2.g10528.t1"/>
        <property type="gene ID" value="PSU_v2.g10528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10528.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27421" checksum="25C877EBC76DCB6B" modified="2023-02-22" version="1">MDAFGNPRALASDVIQSLQGLVFESDVPGFVYRLGFGVSQSLSKVASSLSHCIGSLTFDQQHELMRRRLMQTPPQSCSNNGSNGSAMSHFCNGIKGFGLGIFGGFTAIGDNIAETAKKDGIFAGITKGFVTGMMDTVTRPTQGVFDLLAGSASAVKEVVGNHSTKKSRFPERRLRVPRIRFQGMEALIQKIGKHRKMPLVHVDWQQHIKNQKLEDNLLKYDKNKKNKNMDNANSVQKDAQAEYSLSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVH5</accession>
    <name>A0A914XVH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVH5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10975.t1">
        <property type="protein sequence ID" value="PSU_v2.g10975.t1"/>
        <property type="gene ID" value="PSU_v2.g10975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10975.t1"/>
        </source>
    </evidence>
    <sequence length="519" mass="56437" checksum="0DB35E7934A76C33" modified="2023-02-22" version="1">MQNQLVVLQKVINCIDSTGTEVEIGSFFTTEDENGNHQTTECLGDYFKAKKTVLQWTKCTLPSGAKVTEGNFHVQLLTPKTTSNKPALQKGEILSCIRNGKEVGLKCTGCVSEHTSVHVGVSGYVEVQGQWTQCRRTKDGCRLINVTRNYVDCQLQGSSATYQNGIYFNDTNGISTYYCNHGVVSKQGCTIDGQWALVGEVVYSSNGEAFLCDSSSTYSSFNGLKGCILPDGSVKRFQEIWKDEDVMKRCYWKNGPSGPSEDVIISYACIRGEEIFPENKIIQRENGIYEKCVRGFDGELGFRKLNDKELKEFIKRKTLRLDLSEYYANGGKGNIERFADAPLSPSPSPSSSPSASADATPTTPSTETSTNAAATDSSSPPSTSIASSSTSSSTISAKKSQESPASEPSFPPMDDIMKESLTVSEATQVTINNNSPSSTASSSTLRTNESCIDLVPFCSQISSYCPDFDRYQMIDGETGAGKDTISSAIIELQDLVSGNLGKDKNGHRPISPCEARMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVL8</accession>
    <name>A0A914XVL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVL8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11983.t1">
        <property type="protein sequence ID" value="PSU_v2.g11983.t1"/>
        <property type="gene ID" value="PSU_v2.g11983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000009">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF48">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11983.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11409" checksum="34BDCEF0E1B3B3F4" modified="2023-02-22" version="1">MQQTCPTCHGSGKEIPDPCVVCHGEGKVKKTKTLQVKIPAGIDDGMRIRSSGNGEPGVNGGPAGDLYVEIRIKPHGIFQRDGEDLHCELTIPFTTAALAERWKCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWM8</accession>
    <name>A0A914XWM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SANT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11628.t1">
        <property type="protein sequence ID" value="PSU_v2.g11628.t1"/>
        <property type="gene ID" value="PSU_v2.g11628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11628.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14618" checksum="0023EBFD04C0B0F1" modified="2023-02-22" version="1">MELLKDEEINKYVLACQAKSQKCNIHFALTHLAANKYCIKTALKTFDQKFCGKNFSEFWTSDELKTFVRIMNNTNNHKHKSYKNMHKISKNIPNKSTGDVVNAYYALKKNNCSFGRVFTICPEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX11</accession>
    <name>A0A914XX11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-tRNA synthetase type1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1175.t1">
        <property type="protein sequence ID" value="PSU_v2.g1175.t1"/>
        <property type="gene ID" value="PSU_v2.g1175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000002">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-tRNA synthetase type1 N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1175.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28891" checksum="C05F1D308F445A5A" modified="2023-02-22" version="1">MVLDIDLFRVAKPSGNPDIVRKSQKDRFADVTLVDTVINLDEEWVKERFHLDTWNRMRNVCNKAIGEKKKKKESDGTNTTVPNDLVEKLDKLTIEDLKSLQISQILTARATIEENITKSKERVEQVENDRNSKLALIGNLLHESVPISDNEDNNRVERTFGDIKSRKKYSHVDLVVMIDGFDGERGTAVAGGRGYFLKGALVFLEQACIQLALRILLKKDFTPLYTPFFMRKDAMQEVAQLSQFDDELYKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX17</accession>
    <name>A0A914XX17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XX17"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11074.t1">
        <property type="protein sequence ID" value="PSU_v2.g11074.t1"/>
        <property type="gene ID" value="PSU_v2.g11074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11074.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14680" checksum="06092C7000B8FBCB" modified="2023-02-22" version="1">MYKEAGQWPEAYRIAKAHGGDVVPKHIAYFWAKSLGGDSAVKLLQRHGLLNDAIDLGVEKGEFDFVFELCRLGAKHKLPEVHVKYAEQLEDAGDFAKAEQFYLQANKAREVVLMYMHNQDWDSAERIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXR3</accession>
    <name>A0A914XXR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11317.t1">
        <property type="protein sequence ID" value="PSU_v2.g11317.t1"/>
        <property type="gene ID" value="PSU_v2.g11317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11317.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16711" checksum="4A6140F3FE47D793" modified="2023-02-22" version="1">MKENYPEICHDVMKGEVDLFCCPVSKMFASTNEMALQYEQKLTAVGCDFDEYSRMVSMTDGARRFLQDKLTPATIVYFAFGAEYHQYLIDDVAVLSKLSIPLLMVIAFQPRFADSFRKKACALLRRKLPTVLGNFTAVQRKAMVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY35</accession>
    <name>A0A914XY35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10626.t1">
        <property type="protein sequence ID" value="PSU_v2.g10626.t1"/>
        <property type="gene ID" value="PSU_v2.g10626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="150"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="247"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="348"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="533"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="616"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="706"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10626.t1"/>
        </source>
    </evidence>
    <sequence length="768" mass="83852" checksum="516AB797B164AF85" modified="2023-02-22" version="1">MQTVTQKPKFIGHLALIVDHYVVMFIKKVKLRDGEYHCTATNEFGTGNADPVRLVVTDNEEPPTARVEPRVFNGKPGDKHQFKCHTSGLPPPQVSWTGPNGGPLPEGVTDLGGGVLEITDARKELEGDYTCSAVNIVGEATDHGTVHLGPSLTVRTNPSGPRIILTVGEPLEIKCEAFGEPDPEVEWLHDPGPERGDLPDDFKPVTISEQFIRHPSIGLMNAGKYTCKGSNSQASATKDIYIEVVEPSHVATVSILGGSNQWFTLNQPAQLICAATGPSLVDKVEWARIDGSLPVDVEDHNEQGLLHFGTFQPSYAGEYECRGYRKGELIGSSKVTVHPDDGTANDIARVEISPPRIRVVNEGDSIILNCNVKGSKNPRALTWKHYYRPSKKSHAKRPKITIISENAVAGKKRKVIELQDVIGNGKYLPLQNVKLENSGIYTVIANMSDGSSVIAEPAWVVVKPRGFDGEVTYDWSLARGGNLVRQLGSEKELVVKKADPTNDYGVYRCEVEDPDSKVIGTAFSAVTVGYSTPEKAEIAKFEEATDAELVCPVYAVPGSTVSWTRDGDELPSNAQPRGNKLHITEFDDSTAGLYTCSVQIDQNTIQGFVDARIFVPDTTIKVVLNVSSENVAVGERVWLDCTVVGDPDATIEYSKDGSDKLPSGAQVTGSRLLFNAVKEEDTGTYQCKAHTSEGTLVTTAVINVGSGKRKRKNSNRRRARRRHHRRHNNANNNSLSGEDSSSSSARHHRALRKEHHKNAVFGDWFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ77</accession>
    <name>A0A914XZ77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZ77"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12516.t1">
        <property type="protein sequence ID" value="PSU_v2.g12516.t1"/>
        <property type="gene ID" value="PSU_v2.g12516"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12516.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39563" checksum="ABEF187F2ED4ABF8" modified="2023-02-22" version="1">MTLGGAIQYIGAITFMPELFLLGRAIAALCAPLSDAALILYIQESSPVAYRATFSFLAEIAYGFSSVLGLLFGMDSVFGNSLSTILLLPIFPGIFFTLFVSCVPDTPKYLMIVKKNRKSALKSLEFFQGEKKENEQLLENFIIEGNHEDHEKQSSFTEILGTWHLRQAVFISSAVLAFTLPFYAILQSSTYFFQHIKIDNDIAQLASTNLMLIITVSSTIGSLFIDRYPRRFLVLTFGSLSTFFLITFVLFSALTEIFIWSKYAALASMFLFAVTYGLVLGPVSWFVAPELIVGAYIFIPLFIIPSILCLLYLYLRLPETLKKETHEIIDSMHSRRKQMEESLCPSESSDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1I4</accession>
    <name>A0A914Y1I4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1I4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13316.t1">
        <property type="protein sequence ID" value="PSU_v2.g13316.t1"/>
        <property type="gene ID" value="PSU_v2.g13316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13316.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20338" checksum="6636D6A3B7A6F711" modified="2023-02-22" version="1">MLNKYHALYTQPTFMSDFNALYVTAARRKNIALDNVVAVMNRYLNDGATVEDFPGFPKAPSRPINAYISENRDVDHASLEDIVKLRKEFASGSIDTKPYFDQYAEECKVYIDKVKKYLETHGSELQESHIAHVNSIVTKTFKSINAKPSSSSQKKIKKEKKTAFQWYKDANPELLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1M1</accession>
    <name>A0A914Y1M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1M1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11717.t1">
        <property type="protein sequence ID" value="PSU_v2.g11717.t1"/>
        <property type="gene ID" value="PSU_v2.g11717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF0">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11717.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34020" checksum="03BE6F8ECA869A7F" modified="2023-02-22" version="1">MFGPADLSRKLKPMRTQNARIQTHSNKKLKLVLNIQSAANLPERIDKKPMNVLIEATFQSSIARTGTVSGKNANWQQTLILDVDDAIDIHHDLKSITDVLELNLYDKQINKLPHDSREPNTIHEQFEHRWLGRVVIPFSTILTLTKIDGIITIKEPLFFTGYKLHKHKGYLKVMITMDPPVPAPIFSAYENFLPGETPTLMAECRKFEVRNRQLFLNRRYVALVNDSNGKRILASRYLRPIKPPYQIQEILTNSNNLIEAINLTAHIVSCIPFIADPIMFPGVVDLWTTTEQASFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1R8</accession>
    <name>A0A914Y1R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein HID1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1R8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12727.t1">
        <property type="protein sequence ID" value="PSU_v2.g12727.t1"/>
        <property type="gene ID" value="PSU_v2.g12727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12727.t1"/>
        </source>
    </evidence>
    <sequence length="754" mass="85805" checksum="801BDAD1FB03FABF" modified="2023-02-22" version="1">MGNAETKGNFRKAVIDLTSKQSKLDDTNFWGQFWSPNSVSSCKDLFDMIPANDIRSLRENSPNNLATLCYKAVDCLIEARDTMVPQAEQRKVINCIRLLTRIIPFMFEDEEWRTYFWSALPQTDATAKPIPLASALLTCLGDLLFCPGFTVAKLSTSETTENLSVLDSCEYIWQNGVGFTNKPPINAEHDLNRTEILKLLLTCFSEIIYLPDNAENRMRWLQRFASAENRHVLPLFTSLLNVICSYDPVGYGLPYNYLLVGDSREPLVQVALQLLIVCLDRDTQPIGDESGYVDNFFIHYLSRIHREDDFEFMLRGMTRLLNNPLQSSYLPNSVKKVTFHQELLIFLWKCCEYNQKFMYYVLKTSDVLEILVPILYHINDARNDPSRVGLIHMGVFLILLLSGERNFGVRLNKPYISKGNIDIQAFTGTHADLLIIVAHKLITTGNYRLQSLFDCLLTIIVNVSPYLKSLSMITANKLVHLVEAFSTPWYLFSSPNSHHLVFFLLEVFNNIIQYQFDGNSNLIYTIIRKRQVFYQLANLNTDASSIAKSLNNRRGKQGTAATEAAEKTPQSPTIQTPPPPENSENPLAAVNNAKQASGNVEENEGPNFQSTLAKTPAIASMTDKSAEWSQQKPPEGDGNGGDNWIPTTEWVESWKSKLPLQTIMRLLQVLVPQVEKICIDKNLTDEGEILKFLQNGTLVGLLPVPHPLLLRRYQANAATNHWFRTYMWGLIYLRNTDPPIWYDTEVKLFEIQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1V1</accession>
    <name>A0A914Y1V1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1V1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13213.t1">
        <property type="protein sequence ID" value="PSU_v2.g13213.t1"/>
        <property type="gene ID" value="PSU_v2.g13213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13213.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29801" checksum="261FA264F82C24B5" modified="2023-02-22" version="1">MDCSHLKLADFSHLNDLRPRQGPNSWKNKHLPATFLSNQKHDFEEGLRNSKSANDSTLSLHIAAYENSIENPNELDGGEKEEGVQKRDKPLNMVEKWGISKHFIDASKSIIQNSFEFPRQQEDQDSRSELMPFSSSQRLLNPNQSDASGSHGLDIAIGTQSYNLVFIEVLRFQNRFFVSAFSDQTVKEVKNMLKDVANEDGNMELYAFYPKANNFTVLKDDSSLSECGFRPDCSNFHQPGIVYMAFGKENPAYIGDPRNKPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1W2</accession>
    <name>A0A914Y1W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1W2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12770.t1">
        <property type="protein sequence ID" value="PSU_v2.g12770.t1"/>
        <property type="gene ID" value="PSU_v2.g12770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037800744" evidence="2">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12770.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="18789" checksum="DCFFB132E5771258" modified="2023-02-22" version="1">MQTLIYILLFCIYSVFINAQGPYGPMPNMGGYGGQAPLPLPPPLPPMMQGGYGYGGGGGGGNGMEEYGNQQLGAYGNHPIPHGYGPKPFPQGPSQNGMGAYGNPEMQPYGRNFESSQQNYGLNSGGYNKPPQQVGFGDHGIQEGFGFEGFKESNDDESSTASSTLKSSDTSDFTNSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1X5</accession>
    <name>A0A914Y1X5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1X5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14184.t1">
        <property type="protein sequence ID" value="PSU_v2.g14184.t1"/>
        <property type="gene ID" value="PSU_v2.g14184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14184.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30565" checksum="CB2F0F87C71142AD" modified="2023-02-22" version="1">MLTSPISEDIPRAEVVAATLDHIQILLEEAEANNALGESLWANLNTEEPASLIARGFRSLIRFPFFVLKTSVIGIWNFNVLLFKIPLIPFYVLQKTFYGIATFFAPPIEEAESSEELNVEITQNDNSFDEGGQRQAAGSEAASETGFEDLYEFDRCSTELNGISEYNESIAGCLDHEPPESEKDEEVKKEGFVQLSEARPFQNSSFPRRYFSTYAPDLNISDMSDVESFRAFYEPPSRILESPERHDIDEAAPLPLYNLHERQGRNDYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Q8</accession>
    <name>A0A914Y3Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Q8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13407.t1">
        <property type="protein sequence ID" value="PSU_v2.g13407.t1"/>
        <property type="gene ID" value="PSU_v2.g13407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13407.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="21156" checksum="7D79CE25A066630F" modified="2023-02-22" version="1">MKSLPMSLLVPAFTRVPLPTATPDVFKKMDMVSQKITPYMNGVFTIREIANRVKIDAEIVERCVRQLIYCGTIILLPQFLYSNCYYTTEKFKIFIKAFITQKECCEFVKRKSCLPGPEARDILRLYGGLRPGWKLSNWHSRFNPRRQNVDERKLIQFGIYYGFVRKQEIYPVTLKPEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3S2</accession>
    <name>A0A914Y3S2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 93</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3S2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13879.t1">
        <property type="protein sequence ID" value="PSU_v2.g13879.t1"/>
        <property type="gene ID" value="PSU_v2.g13879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13879.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13612" checksum="125398DEEDF0C801" modified="2023-02-22" version="1">MVEKKSTSIASAAAATTDKEKTNQPVYSEAAVRNNFSILENSRTCQAAASGIASGALGLTGAYGFIFYFIFVLVQAILWEYKAGFKWNTFFVNRSLSITHSIVGGLFTYVLFWVFIYGIVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4B0</accession>
    <name>A0A914Y4B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4B0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14275.t1">
        <property type="protein sequence ID" value="PSU_v2.g14275.t1"/>
        <property type="gene ID" value="PSU_v2.g14275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14275.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20751" checksum="0ACAB3F615F1937B" modified="2023-02-22" version="1">MNPGLSKINVSWLGSTISNYSPYSFIVIYDPSAEVMESIRPICETSVVILLGSPHSPAPIIPETISTLSLHVLVHAPPLIDHASSTLPCVALNASLYIPDIPDGTEEEKMMSLSELAVNRECKLATTLLLENLSIYGPYSKEQTNALVRDVAFPGEFAYLIITHKRNFRIANSPKEYVLASQCPCYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Q5</accession>
    <name>A0A914Y4Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Q5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12700.t1">
        <property type="protein sequence ID" value="PSU_v2.g12700.t1"/>
        <property type="gene ID" value="PSU_v2.g12700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12700.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="52538" checksum="610F813A09E64012" modified="2023-02-22" version="1">MAVVGGFLFGYDTGIVSSAMLYVDNNPDMQPLNNFWKELIVAITPGFAGIGSLLAGTTADRYGRKPLIILSSIIFTFGAILCALAFDKWVLLFGRVLLGLAIGFASMIVPVYVSESSPTHIRGASLATFNAMITFGQMAANIFAGLFAFINPDYIGWRLMFGFAAVPAIIQFIGFLYLPESPRWLYKHKSEEECHNILRKVYHNEEAWIKYELSEIATSIEEERQCENTTPPFLRILSTSHVRKALLIGCSLQMFQQLGGINTIMYYTGAIIKGAGVQDNHTTIWLSVGISGVNFIGTVIPLFLVERLGRKKLLLISSFGVIISLCMMGGAFLLVNRDTASTLSMSELNPSLFNSTVKNFNHCLSHSNCDYCVTDDRCGFCAPANMGKVPGFCLPINPEDADKGSTTGFCSPSSSSNISTAYEWGDVFCHTKYTPLPIVIMVVYLLFFACGKLLYYYSTPHEMLIILQECLQFHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4S4</accession>
    <name>A0A914Y4S4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y4S4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14236.t1">
        <property type="protein sequence ID" value="PSU_v2.g14236.t1"/>
        <property type="gene ID" value="PSU_v2.g14236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF877">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="13">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="170"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14236.t1"/>
        </source>
    </evidence>
    <sequence length="457" mass="50217" checksum="60C5E8F24788E6C7" modified="2023-02-22" version="1">MIGGVQQVSIGQGCDYPAIVGHETGHALGFYHEQARFDRDSYVRILTQNIQSGLESQFTKQSQNSMVTFGVPYDYGSVMHYDPYSFSRNNQPTIQTNDLNYQDTIGQRIELSFNDIKKINFAYCNSTCSSTLPCQNGGYTDPKTCNSCRCPSGLTGTYCDTPIQYQSSNCGTLNLNATTTSKTLTQSGYGYCNFIIQAPVGQRVAISVDSIRFNAFTPCESSYVEIKYGWDIGNTGARFCSTVRTRSVTSATNIVLVLYRNLGSGSFSISYSAVTGSSGGGQTTQPPQTTTTRPWWTTTTPCWPWCRNETDSNTETSPIATPPNTEAPTIPSTTETIPTEIPSITRASPIEVPVITDVSPIVPTYTESTLSSPIALIPSTEISPVDEHLESFDKKMTEAQIEGYKMILGIADDFQNSLSNVIEEKRSLLLKRINDLVTKNGIKEQKESTEVFQNKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Z5</accession>
    <name>A0A914Y4Z5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Z5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12776.t1">
        <property type="protein sequence ID" value="PSU_v2.g12776.t1"/>
        <property type="gene ID" value="PSU_v2.g12776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF9">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12776.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="30286" checksum="86448A9A5AD3DB30" modified="2023-02-22" version="1">MSTKTYLVSKNLYINYLFFFDADIGVINPNHRLEEYINPKYDLSFYERTFTFDIMTGSIIIKNTKYAIDFIQDWISLEDNFKRDYGANDQAAIHQMLMNRFYPNHPRKEKCEKIWAKGLILEDHTPYVACARSVLNDTLEFDRIIIYPKGSHKAWVRDIWLTGSEWAPRDFMLHDLEQFKITDDQNKIADQPWWYFPNPFLADAIFHSSLCTFPDGLKCWKYNSTFITSNEIVDNTILKKAAEVRVRYLKLIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y694</accession>
    <name>A0A914Y694_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">USP8 dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y694"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13171.t1">
        <property type="protein sequence ID" value="PSU_v2.g13171.t1"/>
        <property type="gene ID" value="PSU_v2.g13171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP8 dimerisation" evidence="2">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13171.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31807" checksum="0CA12E1583486BD6" modified="2023-02-22" version="1">MGFLEGPLVTPTLIRDPIRRLCTLVDLARPHGISTTVPLFRFCHMLNDMYELAGVYTKEGNIEKAFVLYLRFVGIVVEELPKHKDYATFSLTEKDNYDRQTIRAMNTAEVLKRRIKAKYEQDATTAKKQDNEHDGHESSIGSVPISPPPIDINLKSYVVCQKQVGYSLLFQRVVIPNDLPQKFLDISKNSIESNKFAVIYGKLIRNSLIISHLVITDGSEKILDQLDRSITEIDEDTNEPIELFIVGCVCGTLSQSSVEKFISRSLLTEIVCIVCRRGKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6F9</accession>
    <name>A0A914Y6F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MYND-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6F9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1578.t1">
        <property type="protein sequence ID" value="PSU_v2.g1578.t1"/>
        <property type="gene ID" value="PSU_v2.g1578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1578.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15585" checksum="34A668BDF954B56B" modified="2023-02-22" version="1">MTGITNIIEDENGDVYRFAVYNWPLKTEGNQKLAVSKAIKDFYPNSKVSIMNPYMRLARDGMNVIRVESPEFIYIDKSSTSNKCHCCGKEEGKILSCSGCMMAKYCSKECQKHDWIEFNHKEICKHLKMFSTTMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6Q3</accession>
    <name>A0A914Y6Q3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y6Q3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15126.t1">
        <property type="protein sequence ID" value="PSU_v2.g15126.t1"/>
        <property type="gene ID" value="PSU_v2.g15126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15126.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19256" checksum="2E002B3C87C475AA" modified="2023-02-22" version="1">MIFFCNYMYIGHGSGVRYVGSSTVRRSICKAVAILMGCSSVRIEDQGHGFDGISAVNDYAVAGAPCTIGCLWMVTDGEIDRFFINFIERCFTEWSSNVSNSAVYKTIKENGDGIKFQYPYRLLIKAIVQARQACRLKTLTGGSVVVYGIPVFNDQSSLEIIDNIDDDSMIILDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y757</accession>
    <name>A0A914Y757_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y757"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14579.t1">
        <property type="protein sequence ID" value="PSU_v2.g14579.t1"/>
        <property type="gene ID" value="PSU_v2.g14579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14579.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21175" checksum="DB517EF6B9DA04EF" modified="2023-02-22" version="1">MNGELDNEEQKELGIFGNDRGDTFSAVDAVSRKIRGGDGSAYGKAMDYCARGKAMEAFDIKDDFGNCDDNGNIVMDIYDIKVGDAVNIVDIYTLEFLPDVIESPGPYDYRHEDICIGALGDLDVSTENDDAEIGVDVTQPGEEYEGSEPEVKDDIVGNICARAQQMAYDAKEAYHKVKDAVDTANDISRIFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7B1</accession>
    <name>A0A914Y7B1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7B1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1516.t1">
        <property type="protein sequence ID" value="PSU_v2.g1516.t1"/>
        <property type="gene ID" value="PSU_v2.g1516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1516.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12751" checksum="15D9ECB0D9D4AC2B" modified="2023-02-22" version="1">MLHYVPLQRDFLSLNSDTKLLLNELVGNCCESNCVALLQHKNETLEPEIIIADSANNPRRLVEYLPFQDVGMSRSLSTLSLSRSKKSKMIRKWSNKSAKKPVEGFKMKADAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7F6</accession>
    <name>A0A914Y7F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7F6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16138.t1">
        <property type="protein sequence ID" value="PSU_v2.g16138.t1"/>
        <property type="gene ID" value="PSU_v2.g16138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16138.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12241" checksum="DB19F8462E12B62F" modified="2023-02-22" version="1">MDKPEGEHSAKIWGFFRGEGALKRTKSLRKFIGSIRGSIRGRRYRRMQGAASPLNGASPTPNIQLNSPNRLSPHTCKARTYRSTQSRIKKPRIEIEDESSSGATVSTPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7J0</accession>
    <name>A0A914Y7J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyribonuclease II</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNase II family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14715.t1">
        <property type="protein sequence ID" value="PSU_v2.g14715.t1"/>
        <property type="gene ID" value="PSU_v2.g14715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004531">
        <property type="term" value="F:deoxyribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09120">
        <property type="entry name" value="PLDc_DNaseII_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09121">
        <property type="entry name" value="PLDc_DNaseII_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004947">
        <property type="entry name" value="DNase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858">
        <property type="entry name" value="DEOXYRIBONUCLEASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858:SF31">
        <property type="entry name" value="DEOXYRIBONUCLEASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03265">
        <property type="entry name" value="DNase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036688043" evidence="3">
        <location>
            <begin position="24"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14715.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40661" checksum="C1B744C8DF483D36" modified="2023-02-22" version="1">MLNSAACIYFLALFALPIIIVSAKIGCKDQNNNDVDWYVGYKMPQINDNSIPGIGEGAAFYYMDVNMDSFVPSSNDLFGNQQAIAYTLQQYYDNKALKSDFSYVLYNDEEAVNDNDNDEDEARKILYGHTKGVVFFGKSGGFWLIHSLPKFPSPDAYVFATNAKKNGQSILCITFEYDELTKIGTQLYYNHPPIYASNLAPSMESENPDLAKVLSKQYKISSPFSSTLNLQSRGGQKFISFAKTANFSLDLYNSLVAPTLQVPLYVETWRQNSSNTIPLDCKAKYLVLDAITMKVGKTTEFKHTKDHSKLVISTNPNKPFICIGDINRMQSQYKRGGGAVCIELKKLWDNYWPMFLTHNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7Y6</accession>
    <name>A0A914Y7Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7Y6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16313.t1">
        <property type="protein sequence ID" value="PSU_v2.g16313.t1"/>
        <property type="gene ID" value="PSU_v2.g16313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16313.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19976" checksum="66522E8DB0EB730A" modified="2023-02-22" version="1">MGTETVCTIKCAAGFRFVDEHKVVTKFKCNDGRWSPSNNPPACVPIAQEPARYELNVAIRYSVATPVDDGCLKSYTDIAANHFDTLDTVLSQRCSSSVQVYVRFLNVKFTNHENDVIGNYTIQILPTVLKDVFYELCGLTMRTIFDLRIPGATTPIRNLLMLSGDTLASQGALVALMEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y844</accession>
    <name>A0A914Y844_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y844"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15619.t1">
        <property type="protein sequence ID" value="PSU_v2.g15619.t1"/>
        <property type="gene ID" value="PSU_v2.g15619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15619.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19404" checksum="06BC635CFE79BCA4" modified="2023-02-22" version="1">MVYIHGGGFVSGSSREWGYKEVCRKLVSHGLIVVTLNYRLGPFGFFTTGDENIPGNYGIWDMIQALKFLQQILPSFNGDPSNVTLFGHSAGGMATSLLTLTPETKDLFARAIPMSGSALSKSSNNPFLIKHSKMVADALEIDFNSFRLRDELIEVSADQIKEAVKSFINLEIKKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8E5</accession>
    <name>A0A914Y8E5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8E5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15025.t1">
        <property type="protein sequence ID" value="PSU_v2.g15025.t1"/>
        <property type="gene ID" value="PSU_v2.g15025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15025.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18252" checksum="BDC639A5F30A3638" modified="2023-02-22" version="1">MTKKAARTGSTANLIQKKAIKPKIDECDEEEIQIVDESIVNKRKVISQKAVEIYTSYFLKACGFGIDERVFIKNRAKAVMKKLKKYLNQYGFYTLDYTSDPDFAEYASTSNIPSSRVPAQETVSSFTTETEPLQEERRYSNQFQKFKSSLVSYYQKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8L2</accession>
    <name>A0A914Y8L2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbamoyl-phosphate synthetase large subunit oligomerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8L2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13924.t1">
        <property type="protein sequence ID" value="PSU_v2.g13924.t1"/>
        <property type="gene ID" value="PSU_v2.g13924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthetase large subunit oligomerisation" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13924.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11244" checksum="792CE87C4EDBF40B" modified="2023-02-22" version="1">MQNIIDIYKRIQQNGSPISKNLLLEAKKAGFSDIQIARTIKTAEKVIRRTRKYYGIMPVIKQIDTVAAEWPATTNYLYLTYNGIENDVEPNTVSLRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y931</accession>
    <name>A0A914Y931_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y931"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15265.t1">
        <property type="protein sequence ID" value="PSU_v2.g15265.t1"/>
        <property type="gene ID" value="PSU_v2.g15265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001136">
        <property type="term" value="P:negative regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15265.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20800" checksum="CE5436A4BA83AA6A" modified="2023-02-22" version="1">MVPPLVVSLIEFLRNYGLEVEGIFRRSAELNAITRLQERINLGKEIDWINDPEYSGDIQKAVIHASVLLKTFLRSLGEPVMTNANYSKLIEIEDPKNNTEAVRNLIWSLKPANFLLLKTVIQFLTEVAAHSHQNLMTPDNLGVVFGPSTSWPTDQQVPLTQIIHLNNFCAKLITDYEVIFEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAE1</accession>
    <name>A0A914YAE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAE1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16250.t1">
        <property type="protein sequence ID" value="PSU_v2.g16250.t1"/>
        <property type="gene ID" value="PSU_v2.g16250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF52">
        <property type="entry name" value="PAIRED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="13">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="103"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16250.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17910" checksum="9E52FC34BFFDF3F1" modified="2023-02-22" version="1">MEFDDLFIQRKVNKFGGYYFNGKPLSLQIRKEIIRQLNDGIGVTQIGRNLQISHGAVSKIVQIYRATRSIEPKIRSSPYNRKASLSSQKKSFRFSVNEILIDSLPRKHRNSFTEDQKAVLLENFEVSPVPDQTMKEEISKKTGLSDKQISASLSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAR5</accession>
    <name>A0A914YAR5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein LTV1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAR5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17297.t1">
        <property type="protein sequence ID" value="PSU_v2.g17297.t1"/>
        <property type="gene ID" value="PSU_v2.g17297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17297.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15571" checksum="FAC9D0D4C5405336" modified="2023-02-22" version="1">MGKRNKLTEMMTTGSISSSIMPRSEGLRNIDEHFDKICEEYDDEHIGYGASDEEIDDEEEDEEEVTREEWKQRLEEMEGARKIRFEDLQLPSEEIKIKTLLMAAKNEKQPEMMERVTLDQNRKRNHWDCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB74</accession>
    <name>A0A914YB74_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="6">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914YB74"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16010.t1">
        <property type="protein sequence ID" value="PSU_v2.g16010.t1"/>
        <property type="gene ID" value="PSU_v2.g16010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="433"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7 8">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16010.t1"/>
        </source>
    </evidence>
    <sequence length="767" mass="88516" checksum="BFF9BB603E02680B" modified="2023-02-22" version="1">MAGDVGTTNNSKSNIQITIVGAKLATGFLAKSKDIFVELIVDNEAPPIQTSVKKKTSNAQFDEVFTASVTETSVLEFKVFEKPKILENILYASKTAKMSHWIRKESDNGNFSASKITLHATGKDSSKAAEIKIIVNGRVETTRRRSAAASRTNETHNGEASTSNGLSASVTRANGVPKPPNRDTIMPQPTSTTINNDEPLPDGWEMRHDPLGRSYYVDHTTKSTTWERPSNQPLPTGWDMRRDNRGRVYYVDHNSRTTTWQRPTAEIINAHDQWQSTRTNAQENYNGRFLYNAGEDALGPLPEGWERREDPNTHREYFVNHVNRTTQWEDPRTQGMPDAPLPDGWEMRITDQGVPFFIDHVNRQTTYNHPRTGKPLGPFGMQGLQMSMDKTFKFKIAQFRYLCLSNSVPNHVKITVSRTNLFEDSFQEIMRKNAVDLRRRLYIQFKGEDGLDYGGIAREWFFLLSHEVLNPMYCLFMYAGSSNYSLQINPASFVNPDHLKYFEFIGRFIAMALFHGKFIYSGFTLPFYKKMLNKKVTLKDLESVDTEFYNSITWIQNNDIDECQMELYFVIDYELLGEIKHCELKEGGKDIAVNQENKEEYIELLVEWRFNRGIEQQTKAFFQGFTSVFPLEWLQYFDERELELLLCGMQEIDVDDWQRNTVYRHYAPQSKQVIWFWQFVRSCDQEQRSKLLQFVTGTCRVPVGGFSELIGSTGPQLFCIERVGKDNWLPRSHTCFNRLDLPPYRSYEQLAEKLKSAIEMTEGFGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEM9</accession>
    <name>A0A914YEM9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YEM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17751.t1">
        <property type="protein sequence ID" value="PSU_v2.g17751.t1"/>
        <property type="gene ID" value="PSU_v2.g17751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF46">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE UGT-60-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17751.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18773" checksum="13EB2E91A2C05F0F" modified="2023-02-22" version="1">MEMSMVVAGDLTIPAGVTEFRVPIEFSDKMKTEGLAIFQTMMFNKGSAYDLWWTGQEFKDMRIEACQQMLEVDPKIIDSFKAENFDLAIGHFHDLCPLAIAEKVDVKKVVWITHGTSVYDFTAVQIGLRTFPSFVPHPLSSYGDQMAFIDRLINVIWHLSTLDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF45</accession>
    <name>A0A914YF45_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YF45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15999.t1">
        <property type="protein sequence ID" value="PSU_v2.g15999.t1"/>
        <property type="gene ID" value="PSU_v2.g15999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15999.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34794" checksum="E85EEF4D56FA9B0E" modified="2023-02-22" version="1">MNANERRISEAKECEKKALEHLKTSIWKMKTKPEYDSAASEYDRAAVCYKNAENLDLCKQMYLKAAECHGNNKNQFHEAKCKESAAMVARDLKNMKEAGKLFKEAAEGFLYAGVMDTAAMTIDKAAKMMENNDADVAIELYEFGLTLVQQADRSKLAMGFLHRLIKLFLKAGNYEKAKQASVDLIEKYKEVQELPKIGQLVVGMVIMSLIQGDPIEALKQLYHLPDQGTTDFSDERSLSNNIITAYEKGDEEKLQSLLTRPYLKCMDNDYLRIFKFCHVPESKRRNVAAVENGGGGIAAGVEFDENDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFC0</accession>
    <name>A0A914YFC0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YFC0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18142.t1">
        <property type="protein sequence ID" value="PSU_v2.g18142.t1"/>
        <property type="gene ID" value="PSU_v2.g18142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18142.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17519" checksum="76EA88B4EB9F874A" modified="2023-02-22" version="1">MQLTKKNNDRDRYVTGEFRYRNGYCRHNPRKMVATWAEKEMRNLLRMYQAGIRVPKPHLLKSHVLVMEFIGKNGWPAPLLKNAEIDSIAEELYLDCVRMMRDLYRKCRLVHAAVSLGDLFFNVSFFDLFHKRTRTFFMKIIETALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFU5</accession>
    <name>A0A914YFU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein MTO1 homolog, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17632.t1">
        <property type="protein sequence ID" value="PSU_v2.g17632.t1"/>
        <property type="gene ID" value="PSU_v2.g17632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="5">
        <location>
            <begin position="561"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17632.t1"/>
        </source>
    </evidence>
    <sequence length="641" mass="71260" checksum="1E4E612CF936624D" modified="2023-02-22" version="1">MNPSKTLAASKKAFQCIVVGGGHAGCEAAAASARSGASTLLLTHKRSTIGEMSCNPSFGGIGKGHLLREIDALDGICPRICDKSAITYQALNRGAGPAVLGLRAQIDRKLYKKFMQKEIFEEIPNLDVYEGAVEDLYLEQPTSPNGIPKVKGVILADGRHIYSDCVVITTGTFLSAEIYKGNVTTPAGRIGDAASYGLSKTFSNVGFRLGRLRTGTPPRLIADSIDFSKFELMPPDEKPIMFSFLNKEPWLAPEKQYPTYLGYTNPTVAELVMKYVKGSKHVAEEINGPRYCPSLEAKVLRFENLKHRLFLEHEGLDSNIIYPQGMSMTFDDEIQLAIMRSIPGLEKCEIVQAGYGVHYDFVNPQQLKTSLETKLINGLFLAGQINGTTGYEEAAAQGLLAGLNASLKSQQKDLLTLDRSQAYLGVLIDDLTSLGTNEPYRMFTSRAEFRLHLRPDNADLRLTQIGRDFGVVNNHRFGIFSELREKYETCKKRLDAIKFSLPKWCQILDGFQTKASSKTLTAFEMLSRHNIALNELAKKFPSELGAFSDDDDLAYRISSESRYAIEHRRLIKKVDEMREELKAKLPDSLDYSKITEINLECREKLANYRPQNIAAASRVPGVTPDVLITLLRYAKRAPVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH54</accession>
    <name>A0A914YH54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18659.t1">
        <property type="protein sequence ID" value="PSU_v2.g18659.t1"/>
        <property type="gene ID" value="PSU_v2.g18659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18659.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12283" checksum="06F799365B917818" modified="2023-02-22" version="1">MAAPSCYGNAGRYYLPVTNNINVNFAGGLTDEYSYYVLNGWEQKTSPTGSPYMAPIVGQQIGPTDTRMNTGGADLRQSVDRDLKAVYQDEYILGFQNMINQAWSGASMPPTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHS4</accession>
    <name>A0A914YHS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHS4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16856.t1">
        <property type="protein sequence ID" value="PSU_v2.g16856.t1"/>
        <property type="gene ID" value="PSU_v2.g16856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16856.t1"/>
        </source>
    </evidence>
    <sequence length="472" mass="52637" checksum="6EFB9D3AAB117C3C" modified="2023-02-22" version="1">MLAPSYDEMPPPYSTTFIDLKPRINETMGYFCAGSTNCQYLDSIIEFSYAGIFMLAVYPSILFCLKLKLKRTFLLGSLITIFGGCIRFGGSLSFLSVTFRYYLTICGHLIVAIAHPLLLCTAPVVAQKWFPTYQRTFATSLIIYAHFAGQMFNFIFVPIIRNFLPDNFGYMILNGIPILICLISMTASWLLSKGSPTTPASASSDGKAVMFQPGTNLFVQPAFIAQIILFGISFGSFKFISLWQFSLFCPQGYLPITASSSFKGFYTFFFLGSTLAGTLLLSAIIDQFHKYKKVYRFCFALTTFGIGLFAWVLQKQDRTTTLLIALFIIGFFGVGSIGIGMETSCETVFPVDSGIVSGMLLSAGYFFYILLAIGTIFTRNLVSYEEFPTEQCSNGLFNQFYEFSDTAEVLSFITCAGLVLCLLGLHARRRRYDYEAAAKLMRISVFNTSHSTIPFRHFPTASTSQTHLASEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKV8</accession>
    <name>A0A914YKV8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YKV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17961.t1">
        <property type="protein sequence ID" value="PSU_v2.g17961.t1"/>
        <property type="gene ID" value="PSU_v2.g17961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000012">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="38"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17961.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30137" checksum="6AF01D0F0B30096C" modified="2023-02-22" version="1">MRTSQYLLSTLKETPADAEVISHQLMLRAGMIRKLASGLYTWLPTGVRVLKKVENIVREEMNNAGAIEVSMPVVQPADLWQESGRWEQYGPELLRFVDRGERPFVLGPTHEEVITDLIRNELSSYKQLPLNFYQIQTKFRDEVRPRFGVMRSREFLMKDAYSFHTSQESLQETYDAMYAAYSKIFSRMGLDFRAVQADTGSIGGSASHEFQVLAQSGEDDVVFSDTSDYAANIELAEAIAPKEPRAAATQEMTLVDTPNAKNHRGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKW4</accession>
    <name>A0A914YKW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKW4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20171.t1">
        <property type="protein sequence ID" value="PSU_v2.g20171.t1"/>
        <property type="gene ID" value="PSU_v2.g20171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20171.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9369" checksum="18559F99A94CD0FB" modified="2023-02-22" version="1">MRRDEEAWKEREELVEPQKEKKDKPKKSKPKATQLPALQFAKKGIPPPIDLKKVHELDSHYLSTHSPQASDTFIEVKIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLG7</accession>
    <name>A0A914YLG7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZNFX1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLG7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19745.t1">
        <property type="protein sequence ID" value="PSU_v2.g19745.t1"/>
        <property type="gene ID" value="PSU_v2.g19745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="1">
        <location>
            <begin position="104"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19745.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25724" checksum="FF66CA6138EE0FF6" modified="2023-02-22" version="1">MFFIDRYTAKTAEDEKEVQARKQYKRRFDDEIHGAPPDDFRNLSIIPTTEDMDIKNNVYLRPAKIDGSYDSDEHYLDVQFRLLREDLIRPLREGIAGYQQGGSKNSDLFVYKNVGLEPAVMHQQTGELVFYANLQISKRMRMNKRLIFGSLVCLSPDDFKTRFLFATVLEREKLIEGKVGLKFEGVLEVNTKWKYCMVESPAFFEAYKHVMTALQVSIVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLM3</accession>
    <name>A0A914YLM3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Superoxide dismutase</fullName>
            <ecNumber evidence="6 13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="6 13"/>
    <dbReference type="AlphaFoldDB" id="A0A914YLM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20460.t1">
        <property type="protein sequence ID" value="PSU_v2.g20460.t1"/>
        <property type="gene ID" value="PSU_v2.g20460"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000003">
        <property type="entry name" value="Superoxide dismutase [Mn], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="109"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20460.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24689" checksum="0FF1AB7F94AA4930" modified="2023-02-22" version="1">MLAKTLRPISSLARPALSFRGKHTLPDLPYDYNALEPVISAEIMQLHHSKHHATYVNNLNTAEEKSLEAISKGDIREAIKLQSAMKFNGGGHINHTIFWTNLSPHGGEPTGELLNQIKADFGSLENLQKQLSTASVGVQGSGWGWLGYCKDQKKLKITTCQNQDPLEATTGLVPLFGIDVWEHAYYIQYKNVRPDYVNAIWKICNWKNVDERYQSARQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM75</accession>
    <name>A0A914YM75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM75"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21436.t1">
        <property type="protein sequence ID" value="PSU_v2.g21436.t1"/>
        <property type="gene ID" value="PSU_v2.g21436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038138079" evidence="2">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21436.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14228" checksum="A47BDD98A71F7F72" modified="2023-02-22" version="1">MKSLLAFVSAAVLATTAASAFAQSADMIPPEMAPRSVGKDGMVCGKVEKARYAEGSDEDELPGQPAAGSGLCHRRHHRHRPDHPAAGHRQRWPAGVPARHLAEQQGNRRCHRRHHRPGDVQAELRRRVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN62</accession>
    <name>A0A914YN62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YN62"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21042.t1">
        <property type="protein sequence ID" value="PSU_v2.g21042.t1"/>
        <property type="gene ID" value="PSU_v2.g21042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21042.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14018" checksum="7072C8E5BBD32230" modified="2023-02-22" version="1">MACEGDNAVLVSITSIPKLNFITDIIIPHEDAHSKEFIFGAHFSLTLKAWAWWSYNNTEILMGPFPELAVQPESDADIYGYMKNYFGFNWEFLPMDDNVAKVYICQQKSYDADNMVSGIYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNB0</accession>
    <name>A0A914YNB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial ornithine transporter 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2355.t1">
        <property type="protein sequence ID" value="PSU_v2.g2355.t1"/>
        <property type="gene ID" value="PSU_v2.g2355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000146">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="114"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="213"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2355.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="32224" checksum="702B3BFB58F4E985" modified="2023-02-22" version="1">MPEEIILEGKSNVTHLKDGIIDLAAGTAGGIANVYAGQPLDTVKVKMQAFPQFYNNWTSCFVKTFNNDGIRGLYAGTTPALIANIAENAVLFTAYGYCQKLVAAVIGCEDPSSMKPIHNAFAGSTAAVFAAGVLCPTELVKCRLQAQTELNPHIKRNAFGICSEMYKQGGVRSFFIGMTPTLTREVPGYFAFFGAYEFTRYLFTPEGKSKDDIGLAKTAVSGAVGGSALWTLVFPADVIKSRMQVTGEGTFGSVFISILKHEGPIAFYRGLTPTLIRTCSASGCLFIAYENTKRFLHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ97</accession>
    <name>A0A914YQ97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2351.t1">
        <property type="protein sequence ID" value="PSU_v2.g2351.t1"/>
        <property type="gene ID" value="PSU_v2.g2351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF7">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE MPST-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="56"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="173"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2351.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32948" checksum="0C610B935B29BDDF" modified="2023-02-22" version="1">MSSQRFIDARDLNTLLNEKKKNNLRILDCTYQVSSKSDAEKYASNCLDNPTAFLKNDTPQFQTFAKSHIPTSRHFNLDFAMAPGDRGPIGGMLFASRAFWIFKCYGHDNLSILNGGFEAWTKGGYEIESFTDSSPPTYPTGNWCAEYSLYDHTINFYDLTTKDRQGKDVFEKSSTDVNIFDARPSPQFNNEADCGFDKSKVAGSHISGTKNLPCNEFVDENGLILSEDKIKQKLDSNGFDISKPTVTLCGHGNQASMLATIIDSIYPHAELKVYNGSLKEIELRAPERINGGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQD5</accession>
    <name>A0A914YQD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQD5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2238.t1">
        <property type="protein sequence ID" value="PSU_v2.g2238.t1"/>
        <property type="gene ID" value="PSU_v2.g2238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2238.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12212" checksum="350351B49AE56813" modified="2023-02-22" version="1">MPNSEAQVAQADQGDQGGVFQILYGQIPEAGHHLWDGLGQADAPQGLALCKVQGLGRFQLGVWHGLDGTAHHFGTVSANVQAQGQGAGHDRVQTPVQTHGLAQNGQGKVQPEQLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQJ9</accession>
    <name>A0A914YQJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQJ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2297.t1">
        <property type="protein sequence ID" value="PSU_v2.g2297.t1"/>
        <property type="gene ID" value="PSU_v2.g2297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2297.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36189" checksum="F7958FDBD8C98B4D" modified="2023-02-22" version="1">MTTSTQEQQQSSDLIKVGFSDLKQGEASNQIVAQAHSEDPDTQMAAVTQTRKLLSSDRNPPIDDLIESGILPILVKCLRSTNATLQFEAALALTNIASGTYEQTQAAVQAGAVPHFVELLRSPSLNVCEEAVWALGNIIGDGPHFRDYCIQLGIVEELLKFVAAEIPLNFLRNVTWVMVNLWCIKDPPPSHEILSSHLPALAVLIHHHDSSVLVDPVCALSYLIDNQIQLVIDSDVVKSLVPLLNHPEVEVQTLALRAVGNFVIGADEQIQLVLDCGALQVMDKLLMHPKENINKEAVWFLSNITAGNEEQVQAVIDAGLIPLIISLLDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQS9</accession>
    <name>A0A914YQS9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YQS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21427.t1">
        <property type="protein sequence ID" value="PSU_v2.g21427.t1"/>
        <property type="gene ID" value="PSU_v2.g21427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21427.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18607" checksum="8CD5144D5F1600D4" modified="2023-02-22" version="1">MTEGDNFEGNFCSTCLLIRPVRSKHCRYCDKCVRRFDHHCIWINKCIGSENHRLFISYLILLQVSAFVVITGCILYINDFCGGISFHNLACQPWVSYTLIMSINLFFWLSLLSFMQFYGIAQGLTANERINAHRYKHLNSGTFARNIFSQGCFQIYTIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRQ9</accession>
    <name>A0A914YRQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRQ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2339.t1">
        <property type="protein sequence ID" value="PSU_v2.g2339.t1"/>
        <property type="gene ID" value="PSU_v2.g2339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF94">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2339.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21973" checksum="54595F90035515A7" modified="2023-02-22" version="1">MRNHRNPQSLIAAGGNEINDQMEAHYLHFFADNRYVVPHCPNLLLLMNCHINVEVVSSIKAVKYLYKYIFKGHDSAAFKIVDGVVHYDECESFLNSRYMGAAEACWRIFGFELHKQSHSISRLPLHLPNEQTINFTDAENIEDLQAAMDSKNKFLDWFELNKRDPKAKVYFYHEIPEHYTWAPIPTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTY7</accession>
    <name>A0A914YTY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3125.t1">
        <property type="protein sequence ID" value="PSU_v2.g3125.t1"/>
        <property type="gene ID" value="PSU_v2.g3125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3125.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32440" checksum="CDB441EE79E33D4D" modified="2023-02-22" version="1">MIKSEAKWFLGKEYQNSVFVLADDSQDRLTQLNRVGMNPRIMISKFQVEKLLEASLSPIVFVKTSAEEKARDVAAQLCKNKESYDIILGFHTVAVMDEKILKKPSTREEALSILKQLSGRYHSVITGVSLLHSTKRVKTFSVETEVKMGEIDEETLKEYVKDDEWIGKPVGYGIYYKGSTFIETNYGNFFNIMGIPVYETIEKIRKMMYGAKKPSTVEKEKDIISHQKELVKVNQTETTAAKKEEVPEKEKIIDDDTKRNDVQPAVDSVIVEDFKGAIAIVEGVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU66</accession>
    <name>A0A914YU66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3533.t1">
        <property type="protein sequence ID" value="PSU_v2.g3533.t1"/>
        <property type="gene ID" value="PSU_v2.g3533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3533.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11637" checksum="2D3FE3303F6F7D32" modified="2023-02-22" version="1">MEEDLKNQKDENTILKNSANTFEQNIVLLENNVKELKLIVERQESLSESMTLLNDILEKKVATLEVQNERQAAELERLCDSLYMHKKNARIEKPEVPKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVE7</accession>
    <name>A0A914YVE7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YVE7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4111.t1">
        <property type="protein sequence ID" value="PSU_v2.g4111.t1"/>
        <property type="gene ID" value="PSU_v2.g4111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10518">
        <property type="entry name" value="SET_SETD1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="548"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="13">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4111.t1"/>
        </source>
    </evidence>
    <sequence length="700" mass="79637" checksum="A3E484827641FEC9" modified="2023-02-22" version="1">MESTSHVVINSPMNLPPTTSSLSSQKIPLKLSDVAPTPPSRIFQPPIIPPPPPPESTATILEIPGPSRTSPPKPQQTINGKVTYVLKPAKFVTQINGAPPTFSVSGYKTIRPMANMIQNPFRPGLYIRSPSKPMQPQQSLSQSALPSVTLTPIPRMQRMIRVIQPASHQIGVISQPRPPPVSQPVPVQVQIIQAPPIRPLPQRIEQPPSTPKKLYTPPKEYPGEVKRIFMPMIERSARLTAINWKQFREEFKDAKASESKVLKPWDVHYQPLSNKQRAAKSILNIEKLPQSTSISLNSQIGPVGPLTEKNTVSPIKSPKKSLSIISSDSPQKKQKRKIEHDDKEVVKKKMTKFFGKKIPKTEIRHIEPKIFPLRSLQDEYILTVRQDDISAEDHVYNHIAFNRLLKDGDLSFLAEMRLPNDPEDMPGMMAQIKSANSKLFKTAAYLDGKTKAPKESPIVNNKLLPPLDVPTEEEEKIHPKEFGCARVRPFVRKISSISPTRKRVGKRFTVVTKEDEENMKRAVVRGKHERHFTRQILTQLQFEQPELAKLDIFKSTSTYYKFLKHAKSPIHGDGLFALAPIEPDQMIIEYTGEKVRHEVANFRERKYEKQGLFSSYMFRLDDDWVIDATKMGNLARFINHCCQPNCTARIISRNGVKRIFIFSKSYIEKGEELTYDYKFPLEDNKIRCHCGAKFCRNFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVS5</accession>
    <name>A0A914YVS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVS5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4687.t1">
        <property type="protein sequence ID" value="PSU_v2.g4687.t1"/>
        <property type="gene ID" value="PSU_v2.g4687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="3">
        <location>
            <begin position="488"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4687.t1"/>
        </source>
    </evidence>
    <sequence length="724" mass="77664" checksum="3F86EBC462C9F40A" modified="2023-02-22" version="1">MLKKVLNAPEVVFEEGPPQKIDEERKPSDSQGSSEVTLAKGIRTTEEPFPEEVTEQDPFATTAAPELLTTTKIAVVVVENSEVDENKETNQQSEAIQSPEESKPQIEENSAPSQETPSQQPESPPVSPIVIEEASTTSESDLAVPNVPINGDTSEDITATATIPETLAPTEDPTSVVQNNDDDVFAGDKSLFQQESTMKALTSTDEAVPIVTEAVPAVTIEPVFPRIELPTETGEEKEESNSEAEAVVITQKPLESQPEISTDDKESEGELPFAPVASLMPSETSETTPAMKVENVPVVPVVVAVAETPAPESSPEPAPEPSPEPTPEPSAQPVPVEVVSTKEPQPEPEPESTVEPVVVVAENENVAPTAEPSAEPEPTTKAPDASPEPEPEPTAEPTVEQPTPEPEPKAEPEPSATSTTTEIVAIVVEEPQPEPNAEPEPEPSPEPEPEPTAEPEPEPSTTPFVAIDQHHHHHNHAAAAIIPIVNPEAHRMPFSLRFPNIEYNDEFHNPQSGSFRKLNEQIGHDYRKVLTKVLGDNFIDYEISEMRPGSVIVDGRILTKQEIMDPEGVVEQIEQVIDANGGTLGGNQVDTKSITVNGFVSKANVESISDPAATKTGLVIFAAIGIGFLIIAAIRKRNAKRDTHVMNRRTNGSMKLKENIDLAENGRSSYQPPGNVNLMGYGSRTNGVTTNGTDKQPPTTTTNTGMVMNSSQFSSPTALQTTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWF2</accession>
    <name>A0A914YWF2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YWF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2411.t1">
        <property type="protein sequence ID" value="PSU_v2.g2411.t1"/>
        <property type="gene ID" value="PSU_v2.g2411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="328"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2411.t1"/>
        </source>
    </evidence>
    <sequence length="472" mass="54349" checksum="BF19E5D20ECA6F09" modified="2023-02-22" version="1">MFDIPRTITETAWLKEITILRRTGESKDVMVQGYPLSHFLKLRNPTEKGSSSRGTAIYETTALITNVQDADDPDNLLTIIFDELQKMAFSSKSGAPDLMNVQIFGEGMGTPFYIPMRSPAQNNTQAIKAQFLQLSTSETLTSIFNNELSVKICGYWAPGGSECVHDVYAKQLLKVIGSNFRLVVYNDIKQVIMNTNHAKHVIFLQLKYNHFDVILKPHLFLNVRKICNQCLKSMQPNYHPRGCMPKFIRYIYFDIESQIIHGAHKPILLSCYTYCTSCADNNVDIDDQTRSKECRCGPSLRYKSFNGFDGISPVDKFVDYIIRFNSKKPAKTIILAHNFSRYDGHLLLEVLYQRNYDVDIVAQGFKMYSMKIKLPGQTIEFKDSLNFIPSPLKDLPNMFGFKSDSTKGYFPHGANTPENLHKTFNCLPAPEDYWCDMMKPEDRKNFMEWYAKNKHPLLILQRKWSHTVKWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWQ8</accession>
    <name>A0A914YWQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 35</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4400.t1">
        <property type="protein sequence ID" value="PSU_v2.g4400.t1"/>
        <property type="gene ID" value="PSU_v2.g4400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4400.t1"/>
        </source>
    </evidence>
    <sequence length="537" mass="61442" checksum="9E2884C47DCA4B13" modified="2023-02-22" version="1">MALSESTILETEQEHLLDEALKIVRAESFEMKRSLDKGLQIEAFKHASTMLSELRTSALSPKFYYRLYVDIINELNHLSTFLVDDSNNENRLQRFAEFYEVVQYAGNIVPRLYLLITVGVIYFKMEGAPKKEILKDLVEMNRGVQNPIRGLFLRNYLLTCTKELLPDTTPDDDSNPAGTVNDAVEFIMVNFSEMNKLWVRMQYAGPSKDREKREKERRELRILVGTNLVRLSQLENLTFDMYQKIVLPGILEQAVSCKEAISQEYLMECVIQVFPDDYHLSTLHEFLEACAELNPDVQIKNILNALIERLAIYAVQEDSPGIPDDVQLFEIFSLHAGNVIGARENMPPEDIIAIQSSLIHLAIKCYPERTDFANTVVDSTCKLLKTQKIESAAPNSNIGKELLKLLKIPIDEHKNIIKLLDVSELSNLIQILNFRGRAIISSYIINSILDNENSLTEEDHINGVFKMIETLVEEELPEDVEIDEDFREQQELVAKLVTAIHNDDLDTHFSLLKTTRKHFGKGGKHRLCFTLPALFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWU2</accession>
    <name>A0A914YWU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWU2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4571.t1">
        <property type="protein sequence ID" value="PSU_v2.g4571.t1"/>
        <property type="gene ID" value="PSU_v2.g4571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4571.t1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38207" checksum="A905F46A6AB82524" modified="2023-02-22" version="1">MEYASYERASSRPLIAPIPYNFSFFNENYQEKPIKSKEILDNCPEDFASESHITQRPTTYEHYSGGKTYRFIDTVGYSSEIKDSAILNLELFKTLKHVDAVWIVVSANQKLEDDDYSWINQIIKPIPKKLFLRVYFVFTHIQGKHSLRFNLNVNAIASYLSKFKEIPFGENNVFAIENDCLKSLYAQGAGCSLSGVQDSLGKTWNESRNVVLDLLDKAAAPKAPDDDIYFLNNLFYLFLKLKRFRSSADLQECCNLLSHNFISSKMGNDKPPPSYEDVFKSLISFKSKIPDASPQHKVLIEFIETFEDFIKKQHSSTFGTALGYGKKLFSWLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX07</accession>
    <name>A0A914YX07_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YX07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5060.t1">
        <property type="protein sequence ID" value="PSU_v2.g5060.t1"/>
        <property type="gene ID" value="PSU_v2.g5060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5060.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11383" checksum="F61B775BE72B536D" modified="2023-02-22" version="1">MVIVQMVYFRCTSAGPHFNPHGKTHGGPDDEIRHVGDLGNVEARSDGTGCVEKKDALISLSGEHSVIGRSMVIHAKGDDLGRGNDEESKKTGNAGGRIACGVIGLAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXD7</accession>
    <name>A0A914YXD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine aminopeptidase S33 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4311.t1">
        <property type="protein sequence ID" value="PSU_v2.g4311.t1"/>
        <property type="gene ID" value="PSU_v2.g4311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF39">
        <property type="entry name" value="SERINE AMINOPEPTIDASE S33 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="240"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4311.t1"/>
        </source>
    </evidence>
    <sequence length="435" mass="48329" checksum="4DE23D957AF52D61" modified="2023-02-22" version="1">MWLFDVLSAIAFEDDDPLTFEERKGAGAEASDSVFEEEEKITTEEETTTIKTVIEDGKAKASESVVSKKLQATKTTMTQHGFVGSILNCCHCLATCCLFTYVLCPPVPSCIIRKVAFRPPKQGESYKLIVKDKNGKEKYVGSARAASKYSSLQIEPILLEQRQHPAHFLRCFMQPVDGFIVKSKSGNSLVCAHFKNKYTNLRTTKIYNNKVAIFAQPNSSDIGHFMQPFIVSFRDFAHSIGIDLYGFDYSGYGRSGGTASEQNAYDDIESVFSEIVKRRGSEIEILLIGFSIGTTAVIDLASKKPKNLFGVVLIAPFTSGVRLLKNAPRLEKTPWYDCFESYTKISHVEVPVLVCHGTEDSMIPLLHGQVLYERAPQKVDPVIVDGANHVSILQSQHVHLAIRLFVAKQLQNPSSPLKEASTINNRSDSNSEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXE2</accession>
    <name>A0A914YXE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXE2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4316.t1">
        <property type="protein sequence ID" value="PSU_v2.g4316.t1"/>
        <property type="gene ID" value="PSU_v2.g4316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4316.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19749" checksum="4A9446C635AAC898" modified="2023-02-22" version="1">MSNDKIDQIRTSPTGKYVWGYSLTSGRGFARSQINDITTVKGSTWIETPLDIKIGELAIGENVVWAIEQGTTKVYRLRNLSLSNIVGIGWRLMPFKLRALSVDSIESRLWGLNGCSRLIKHEMDIYPRKCLQNNKVAAAPLKNECINNKRASSDSSSESWMDVGGNGYTLCKDIGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXU7</accession>
    <name>A0A914YXU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF268 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXU7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2905.t1">
        <property type="protein sequence ID" value="PSU_v2.g2905.t1"/>
        <property type="gene ID" value="PSU_v2.g2905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004951">
        <property type="entry name" value="DUF268_CAE_spp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03269">
        <property type="entry name" value="DUF268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2905.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11204" checksum="7290268C3709B5C1" modified="2023-02-22" version="1">MDYIYALDLPLISKKYYNKFDFIVSFSSIEHSGLGRYGDPIDPIGDIREMNKIHCLLKNKGLLFLGLPVGIDSILYNAHRIYGRIRLGMMFEGDICLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY38</accession>
    <name>A0A914YY38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YY38"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2989.t1">
        <property type="protein sequence ID" value="PSU_v2.g2989.t1"/>
        <property type="gene ID" value="PSU_v2.g2989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF111">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2989.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26713" checksum="245F0E5151C44C4C" modified="2023-02-22" version="1">MASSYQLMESWNQNIPDQFFPTPEMPKRKPRSQKKKAEGKNLENRVKRKKCPAKEKERNEAINSGFEALQATIKCIQNGEKSSKIPKVKVLRIAIRYINYLKQKLETPDELYNPSMDDFVLQAMDVIQTKNCYTKRAAQEIDDIPDSQIHDDPGYISPPEFSITPPSNYSSDYFEIPSNQFSSMDSSSSSSLMPLNPSNFYSNFPIPPPSYAPPHFQMMDYENYPAWKQPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYX0</accession>
    <name>A0A914YYX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYX0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3241.t1">
        <property type="protein sequence ID" value="PSU_v2.g3241.t1"/>
        <property type="gene ID" value="PSU_v2.g3241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3241.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="35677" checksum="184324924BBFBB32" modified="2023-02-22" version="1">MNGLIPVDHVAEPEVFELRMFGKKAMLDVFLDTVKVNAMLDSGACASVISEAAIGKILRQRPEAVRRITEEDPKTFMHKKLVGADGSPLNVVNCLRIPIAWGIQQPKLAKFFIVSGLQQDVLIGTNVLQDDDIWIEALSSSLKTNKGDKVGIVPQATTSINNVGYKVNVAYRMVVPPHTTAFMKVGVPIKGDAILEAGAEGLESGFCNSGRGFAYMKYCNASDVIQVFEKGEHVAEAFAAEVVTDIVYPKVESEEVIHVVTDNMERIQRLQDLLNMHAPGFSAKAKIRLKQLMETYHAAFAVTDDEFGRTTTTCKTYPITDEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZH8</accession>
    <name>A0A914YZH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5348.t1">
        <property type="protein sequence ID" value="PSU_v2.g5348.t1"/>
        <property type="gene ID" value="PSU_v2.g5348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5348.t1"/>
        </source>
    </evidence>
    <sequence length="425" mass="50458" checksum="8428E50330C1D63E" modified="2023-02-22" version="1">MQLGAVWTPMTDQLRKQLLENKELYKKIKSVEAIPKQWFNAVIETDDLRYIVQNVEARIAREIDAQINEKKLNIQLWYMYIKYLLTKDRLLAEEVYYRFRRIFLYQRTLENAFPQFDGKLSEDAKSAMENMKFNHPYKFTPLPSSPLTIYSNEKWVKQVLPFRESLMHYIFQKASFKITKKLYASCKHLYFLQRKPIFHSLYVGNELKLQYFRNSMATDGETSEFLEMDKIILTNTLIVQHSENSNLLHSISPKFASCNLRFLRVTNQSFFVNEYKFLTEAGRIMKLVFQKVTIKDENGEPIILENFLYNLPQAMYIDAPIKTRTTSETEKLLFTWNKPTKIHCISLLLDDELMEILRPMRLFKFLSRLVVNVKKSTNVVQFEKGNENISNYLQDLIASTQIWKHEHNDQSPPKVLTLKDYENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZQ7</accession>
    <name>A0A914YZQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZQ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5584.t1">
        <property type="protein sequence ID" value="PSU_v2.g5584.t1"/>
        <property type="gene ID" value="PSU_v2.g5584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5584.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33822" checksum="C812EEF65DE513CF" modified="2023-02-22" version="1">MTKTHSVRQNHKIKFLRYILRRKQCATLALIEVALFVMLSSFCIGAYFGYTIFNDQRIEIDNENAVIDRYAENITFAHCKFIEVTDFNTQFCKNRIGVVAFAYRYHALESDSDKTCLDINEQIYCHEYFIENTLFNPNPLLKSKEYQNGCPGFSNATLNGNNEDEKRIIPRNFNEFGNRSVVHIQELFIQCPKCIPDGPPTKENSGKNCFQKIKTQEKGWPWFGEHCKEGEIVDCSLLPTTATTSTTPSSDSSNLEMTTISERMTTLKIVRPQNMLSLLHEQQQIMSEMNDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0A2</accession>
    <name>A0A914Z0A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0A2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5601.t1">
        <property type="protein sequence ID" value="PSU_v2.g5601.t1"/>
        <property type="gene ID" value="PSU_v2.g5601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF16">
        <property type="entry name" value="BLACK MATCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5601.t1"/>
        </source>
    </evidence>
    <sequence length="612" mass="69817" checksum="5DB5387FFB58E8B6" modified="2023-02-22" version="1">MPTKDVPDIAETTIPLEKYYCNLRNRGIAGQHWMLFDANSHIGKVKRNIKAPSRIGRNRLSLIDLLRYDVSQLASVVHPRILRILNNVEENKDCICFASECVHGTLDQIVVDEGMDKLEMKLGVLQIIDGLSYLHNSAKILHGNLTPTSIFVTSTKLWKIGGFQFAVQGTVKYPNLFPCYPWTKKLPPQLQPELDFLAPEYLNSSNQPQVTNAADVFSLGVLICWIYSGGKRLIDANNNLESYNIIINQLDAALSLITDELGQNLSECIAKVVSLDVKNRPAVQFLALIKHFDDPTLTVLRQLDDISQEFVEEHKISFISQTLYSALPMIPEQLWFNRILQRFNENLTEYIELYSAILRPLTYMLNNCESHNIYKLRAWFRRITANTTINNEELTVLLLDNLPVIFRRLNDEEVEDRCYALLLSTLNGSSNKLKQTALRIIPYSVDYMSLGFVRAKLIPLLLTMEKYFQDNIQRQVELLVAVAHLSDRCDSATLQYLLTVSSVCTSLHPSIVHSKSRLVQRILHTDVSRLTDSLVITHHLLNPLILGLALPEMTSAHFDDVMSSIRILLDIVEQIRYENDDAGLKRNDSGRLYNRRVSMSSSHLPRLLRMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0U6</accession>
    <name>A0A914Z0U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0U6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3897.t1">
        <property type="protein sequence ID" value="PSU_v2.g3897.t1"/>
        <property type="gene ID" value="PSU_v2.g3897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3897.t1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62190" checksum="64F313B6B270445D" modified="2023-02-22" version="1">MVTRRQAEVKDNNRKKTQRIREKLTELRKKEQDLTRKRRQNCIDTHTKVKLRRLEEKNKELKEALESSANELASTQCEPSPNFFKHYQSLLNIHKHQNLLQPHSAPPTTRLMAEASTRLKNTVGLSQRNYEKLRNELAMEGIGMPSPSTIKRKSNQISDGHCRISDRPDFYGLIEKAVMKHDFSSVPNVRITICGDGGGDGDKFSVKICCFFNDIALPLSIKNLMIIWSYVGKETREKLKDILKYIDPDILNLIENGIFTKSGLKQVIITYIGDCKFLCISFGLQGGSAVCGCSHCVTKRSNWATAKSEDIVPRTISSIVANAEEVVNNNGKPALHESVDNFPLLFNIPVTHIAPPPLHILICLVNSIVDYIRKYAPDNVELEEFLSEAGVRLHYPAKAFEGNACRKNLKQFREETSNKIIYGGFGSNLFEAAANIEKHAVARTLLEEEIDDLDDRIRLFFNLLKEYGQVAVKFFLNKNKIHMLQHHVVPFVRRFKSWGLFSEQSGESIHHVRNDLDDRIPGTGPKADEKRNTFFQKNQAVSFHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z150</accession>
    <name>A0A914Z150_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z150"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6090.t1">
        <property type="protein sequence ID" value="PSU_v2.g6090.t1"/>
        <property type="gene ID" value="PSU_v2.g6090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6090.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47263" checksum="1E01C9D6848737F1" modified="2023-02-22" version="1">MQFKASQQLLNPNEEPPPKKSKTNPVQDLARKHIRIAKTIVDLNVDEIVTRLTADFTLCLIFGHHDIPKFKFQMVDIIQTLPTTIHGSESFELLNEKQKITTRAQRDAKLKEKQLDAQVEPKEIDESIQQDEGDCDEEAENNDGDQAEEVTDELLNETMQYVAELVDKNEVPEGISSHFDEAADLLWIVLKSGKHNDRSSPVNFKAEEKEVLEKLHSAFRSFFLNPSPRLNHSLDVATIICSYARLLKHGKSGVKQFIKEIHGEIDEDDVESEKNINDVLTTWLEAIDAGVIKQFQRNGFKSEYPLSVREATITSGIHSVVKFFCYVAAANPEIIPANFLMDENLVKQQLENWQQHLCIDYTRKSHFHSTEKNFSEGIKDASRVTYEDEPDRIRLLTAVKIYSSTVTGVRHTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Z2</accession>
    <name>A0A914Z1Z2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional purine biosynthesis protein ATIC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">AICAR transformylase/inosine monophosphate cyclohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22193"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate</text>
            <dbReference type="Rhea" id="RHEA:59144"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57452"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:59145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:18447"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Z2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6724.t1">
        <property type="protein sequence ID" value="PSU_v2.g6724.t1"/>
        <property type="gene ID" value="PSU_v2.g6724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6724.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17959" checksum="DD2C154748CDD9FE" modified="2023-02-22" version="1">MENKQLAILSVSDKTGIIEIAEALKNANLDLIASGGTAKTLRDHGLQVHDVSDITHFAEMLGGRVKTLHPAIHAGILARDDNPSDMKDMETNNFALVSVVICNLYPFSKTIASDPKCEIPTAVEQIDIGGVTLLRAAAKNHARVTVVCDPSDYLTVIQECSLRSLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2D8</accession>
    <name>A0A914Z2D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2D8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4413.t1">
        <property type="protein sequence ID" value="PSU_v2.g4413.t1"/>
        <property type="gene ID" value="PSU_v2.g4413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038123201" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4413.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20122" checksum="4EABD7AAA953839A" modified="2023-02-22" version="1">MNFVLLVLLKHLELILYAANDKKHPFEFVGGFRLQKPSKEERVTVLGEIVQECFKRFKVNRGQYPRKLILFRNGCSEGQFKMVLSTELPFAIGASSDLKYDAQVTLIVPNRFALQGTAKTPRFTIIYDGNIDDAVQLWCYNLCFGIQIDRLPTSLPSPVYIATRYAERGRALLNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2H0</accession>
    <name>A0A914Z2H0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acetate--CoA ligase</fullName>
            <ecNumber evidence="1">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="6.2.1.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z2H0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6096.t1">
        <property type="protein sequence ID" value="PSU_v2.g6096.t1"/>
        <property type="gene ID" value="PSU_v2.g6096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6096.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17258" checksum="30DBB9242704DE1C" modified="2023-02-22" version="1">MLSVQWTFDAKDSDVFWCTADIGWVTGHTFITYGPLAAGVTQVVFEGVPTYPDAGRFWNMIERHGVTVFYTAPTAIRSLTKAAEADEAIHPKQYNLDTLRIIGSVGEPINPEAWMWYFKNVGRERCPIVDTWWQTETGGHVITPLPGATPLKPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3L1</accession>
    <name>A0A914Z3L1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3L1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6946.t1">
        <property type="protein sequence ID" value="PSU_v2.g6946.t1"/>
        <property type="gene ID" value="PSU_v2.g6946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6946.t1"/>
        </source>
    </evidence>
    <sequence length="657" mass="75731" checksum="3759F1221DED3777" modified="2023-02-22" version="1">MSILTVTKVSLNGKDYECRRKVEISENVPISEIARFFWPRIAPNFICKSIRVFDSDLDDFTDIEDPESQFAEAKQKYEFCYTEGDAATTSNSNVISNVFNCRIEATQNGIAFFTQKANSLNANTNTNNNNNLGYEKKYQKIQSSPFFSSSHVVDLPSTSTTAQSPEPCLSPQIDIQKYLSSSSNHESGNKDDVIQIDSSNITPEQDDSNYELQQPDIAGQLMDFFNTPEMANLFGTVKPDGEISNDGYSHHLHQPNLQNNDESTSVLDIDELHVPNPTEHLENHVERGVFALAELRKYARGEVNFFHDQVKRVLTLAMGDYLFENYFDNCTAPIRREFCRRYLAQLPGNLRLEIFSNSKTVGTVDCYIKNKKKRLRKLALKEAGEFPKSKKNIYKPMENPPERPQAPKFVDDIRIGDHDPNSIEMELLYKKSHNYRQNLINALNKTPGVDCIQEVVYEFPHLISVPNLLEQDFQMVVSRIRQSSVEFEYEYEANWCPRIQKYFETVQSTKYQQIDKLYPMVPDRDSLMAFVMIFSLLEYNALTLSQIKSLIVDYTHTTIEAAIYDLRNRREIHDPVILANPNGYRVLISRNMLPETTRFSTALKQLVQVHYVFRIQHKVLFRPIYQVLETIYGLSTNALRFSQRALSLVENLRSAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3L2</accession>
    <name>A0A914Z3L2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat GAD-1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3L2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7281.t1">
        <property type="protein sequence ID" value="PSU_v2.g7281.t1"/>
        <property type="gene ID" value="PSU_v2.g7281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001319">
        <property type="entry name" value="Gastrulation defective protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7281.t1"/>
        </source>
    </evidence>
    <sequence length="660" mass="73876" checksum="B34A84AD7B2C37C3" modified="2023-02-22" version="1">MSSSEESSKQEHPQEDSHQSTTKDETKSKNSSKKAQHFDFETLFQKTIHDQQIRNAERQATFTDTDREETADVAEQLAAVSLPRRDRGNNIVDANGANNVQVEEDENDDDVGPALPPGFIPDTSVQVKVAQKDMPNEPSQWSNDDDEDVNVSSLIPATYEAKIVHGHKAVLSLAFDAQGSKFVTGGQNYAVQFFDFLKMDSAMKPFREVFPAESHVINTLAFSSNGETLLVGTGEAQIRLLDRMGKQWAETVRGDQYLVDLGNTKGHTAAVNHLCWHPLNKKEYLSCSDDGSLRLWSTDDFKTITKCINTQRKVIKTRNAGGRRTIPTTCCYSRDGKLIAAGCDDGSIQIWKHGHNFANVKYLNRNAHNGAICSLEFSPDGKQILSRGMDDTLKLFNLEKFKEPVHEVKNLPCMFVQSSCGYSPHGEFVFTTTSGREGKGKDTGGLLFFNSSNLELQYRIEYDDTGAVSCSWHPKLDQILVGLSDGTCRIYYDPRSSIRGALLCATRPVKRVRTNEVVKEEMIIAPLALEMFQPRGEEGEEKDVTEWRLRRVLRMQSGRKKPQFRKPAEMPMQGTSAGGRLAKSGGTLHSYIAQELGKSQNQTFIQDEDVRASILRHADAAEKEPLYISKAYKRTQPVPIFAEDEEEDNEPEYKVSKPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3P9</accession>
    <name>A0A914Z3P9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Oligomer composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3P9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7322.t1">
        <property type="protein sequence ID" value="PSU_v2.g7322.t1"/>
        <property type="gene ID" value="PSU_v2.g7322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098957">
        <property type="term" value="P:anterograde axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007292">
        <property type="term" value="P:female gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000067">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="864"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="603"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="787"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="884"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7322.t1"/>
        </source>
    </evidence>
    <sequence length="898" mass="102682" checksum="271402CEB58ED117" modified="2023-02-22" version="1">MEGKSYVYDHVFDEKYTQEQVYQGAAYHIVQDVLSGYNGTVFAYGQTSSGKTHTMEGVIGDPEKQGIIPRIINDIFNHIYNMEDTNLEFHIKVSYFEIYNEKIRDLLDYTKTNLPIHEDKNRVPYVKGVTEQFVANPEDVLAAIEEGKNNRQVAVTNMNEHSSRSHSVFQIHIEQENKATQKKLTGKLYLVDLAGSEKVGKTGAEGTALEEAKNINKSLSALGNVISALAEGTKSHVPYRDSKLTRILQESLGGNSRTTIVICCSPASWNESETKSTLLFGQRAKTIKNVVVVNEELTAEEWKRLYEREKDKNAKLKAQLLHYVGIIAELKRFRSGERVPESEWVNLNEVDAAQLTESTIMTPSMSESTFVPSTAAPPQQPLLSSTTGPMSDEERRKYEEERSRLYQQLDEKDDEIQVQTQLVEKYKSQQQEAEEINKQSQQEYTGALNEIARLQEENGKYREETDELFSAIQEVAMSLEQKKSEVENLVKENDKLTEDFTKKSLDFMDYKAKVDELNEVLASQKRKICESVQSMLREFGELGSNYPIPEKFVGDVVDTDKPLDEEMLAHARICISKLTTDYKSALQKTSELQNGSGDVEKRLETNEKELSDCRLQIQQLDAKNKSLQETIDSQEKAKRSLEDDFDALNSRLASSGGVGAETLNSDQQKVVAQLRDQITEKSNQIKNLNESLQELQLAKEKLTQDYEKLRNEEAEKERKYKDLSALSDKREQAKQDLRGLEETVQKELQSLQNLRKLFVQDLSQRIRKVPVDGEEEFLSSPAQKQKIQFLESNLDQLTKVHKQLVRDNADLRLELPKLEKRLRASMDRIKLLETTVREAKENAMRDRRKYAMEVERIKEAVRKRNMARRNNAPQIAKPIRPGQHYTTPSRPSLPVSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3T2</accession>
    <name>A0A914Z3T2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3T2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6669.t1">
        <property type="protein sequence ID" value="PSU_v2.g6669.t1"/>
        <property type="gene ID" value="PSU_v2.g6669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6669.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22764" checksum="2A53599C25C8DD8D" modified="2023-02-22" version="1">MMNVTVIVEQQQQQPAAAAADIPQIEVAPFQANGIVNGNNDSGVDLAAFVESNHATPIITNGRSISPSASERSDGEPIFQAKPEVEPDSVTRWRKEYEDKLTKLDSEEQKIMKDLKEQAKKELADFEKRRASDLEQRKKVNREKQVEFLKNVEKASAGVLWQRIAKVVENDERTPKNPIDTDRMRQLLLQCKDGGPKPVNGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3Y1</accession>
    <name>A0A914Z3Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3Y1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6710.t1">
        <property type="protein sequence ID" value="PSU_v2.g6710.t1"/>
        <property type="gene ID" value="PSU_v2.g6710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037595796" evidence="1">
        <location>
            <begin position="20"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="191"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6710.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38765" checksum="2291AA118671A5E8" modified="2023-02-22" version="1">MLHLSSVIWLFSLFVLINSLCDRRTPRKEGYLREPCVPGFYEGSCLIILEKMKLHEAMEKCRYDYGGRLATAPSKDAFKVWARTIHFSTKKSITEKSRFWVGYDKSGFKNVIPGGEDSTFDEKRWKDVFNADKFVKIDDWENDENKNQLGNFDCPPEGTIFNPLNHKFDVEGYNRKFHGLCETVRSAKLQCDSGWYLIPPLRMCVKVHRDKIIFLQAHAKCNSEDSFIATAQNIYELKLLRNVIVPLKITNNLRSIGGFWGGLKSEGRTTYSMDGTNPIFSVNTDDNKKKCGAFTYRNFGHDELVGVAVPCNEGGFWDTTYKLPFMCQRFADQSNGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4U6</accession>
    <name>A0A914Z4U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4U6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5275.t1">
        <property type="protein sequence ID" value="PSU_v2.g5275.t1"/>
        <property type="gene ID" value="PSU_v2.g5275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5275.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34175" checksum="82B99AF67924B459" modified="2023-02-22" version="1">MYTNGALNINDILKTHSLLCAFLEFLEDINDNYAQNLLEFIISIRDSEQAKGADAQTLVDDAIIIYDKYFSMQATNSLNFDDVIRIEIESKICTESGIPETNAYEKPYNLACAALQEHYIPNFLKSSPFQKLIHDLSVSIETQYDASNNTVPQYVSPIHRSPSTIQLPPSSPGWIAGLRSSRNRTQSFDRMQSTPRSVCSNLSDDGPEETESQCSTNSLTFTTLNARSKKTHGSLARVDELGRYTPLFNKDVCGPEELPGRGRLRSAIDRYLNNSADKESKMADEVAKLIISDIQDMVAIGNSIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5G7</accession>
    <name>A0A914Z5G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5G7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7133.t1">
        <property type="protein sequence ID" value="PSU_v2.g7133.t1"/>
        <property type="gene ID" value="PSU_v2.g7133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7133.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19469" checksum="E3499898129A7B65" modified="2023-02-22" version="1">MIEELKEAAENRIKFGYFGYAPFAGMHLEHALTLPKTTHGSKRFLSCGITLLCTEFTEPFYLQYKWKPRRNVAEEEETPVNLELEERASSEAEVEEEIATSEFQVVVEEEEVTPSEVEVLDEEEETPTPEFQVVVDEEEVTTSDVEVIDDVKEEESATPELKVTKEETVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5M0</accession>
    <name>A0A914Z5M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-54 factor interaction domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5M0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7247.t1">
        <property type="protein sequence ID" value="PSU_v2.g7247.t1"/>
        <property type="gene ID" value="PSU_v2.g7247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000024">
        <property type="entry name" value="Formate hydrogenlyase transcriptional activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011958">
        <property type="entry name" value="PRK15429.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32071:SF123">
        <property type="entry name" value="DNA-BINDING TRANSCRIPTIONAL ACTIVATOR HYFR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32071">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="259"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7247.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43399" checksum="982FAA8176EFD18F" modified="2023-02-22" version="1">MPLAAEGHIFGGCEFIRYDDRPWSEKEFNRLQTFTQIVSVVTEQIQSRVVNNVDYELLCRERDNFRILVAITNAVLSRLDMDELVSEVAKEIHYYFDIDDISIVLRSHRKNKLNIYSTHYLDKQHPAHEQSEVDEAGTLTERVFKSKEMLLINLHERDDLAPYERMLFDTWGNQIQTLCLLPLMSGDTMLGVLKLAQCEEKVFTTTNLNLLRQIAERVAIAVDNALAYQEIHRLKERLVDENLALTEQLNNVDSEFGEIIGRSEAMYSVLKQVEMVAQSDSTVLILGETGTGKELIARAIHNLSGRNNRRMVKMNCAAMPAGLLESDLFGHERGAFTGASAQRIGRFELADKSSLFLDEVGDMPLELQPKLLHGRASNRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5Q2</accession>
    <name>A0A914Z5Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5Q2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8017.t1">
        <property type="protein sequence ID" value="PSU_v2.g8017.t1"/>
        <property type="gene ID" value="PSU_v2.g8017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF27">
        <property type="entry name" value="PROTEIN CBG26503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="110"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8017.t1"/>
        </source>
    </evidence>
    <sequence length="836" mass="95797" checksum="D168D94BE892905C" modified="2023-02-22" version="1">MSEKSRKRLADREIDVESMKYMGSGELLLTNDDYLNLRVVCPSQAKPNFCKGDKNFMAEVDRCRRNKFEEFKSRKLDLKLFGYSYIPLKTVNTVEAACQTDFEDVNEKKLISTTKKLKAVRNALHNLKRKFERNDKKFSDFRDKMEEKQEEVIDECEEILDELVEHVDILKEGQLNDCEYIKDLQAKIRELESQQLLNKNPPKLRDYNVSSENCSNVIQACFTLAGATANSLPSPSTVLRSVFLTKVLINEQLKEILTSASASTIGSDETTKHAQKLQAYIYRTFNGTEIQDYCLGILQVLNKSAAVSFDTLKKLVEDLGADFTGENKLWNDFLLSIKNTISDQASTQLKFNHLLQEAKRRIMELQSGWDSFTDSEKADLCQIRSFFCQLHILSNCCQVVRSALLLQEHDIRNDLNIVDPTVIQLIKECASYFGERASALHMIYPKWKAYCIEHKIQHYRIPDLKGHRFNIIFTIANSIFYLKDHLINFINFMSTTNDKLDHVKAFLEDPLVLNQLHILAMLDVAVVGPLWRLIENTEAFNDIGKHAASLLVYLKRVKNEPLALFSGELPFSNFSKSEATSERSQNHLNFILEKSPNNPQLASEAVELVVDELIKYFEKQFGDFLSGGKHANVNETDVATVPRSNRKCESVFGLLDWTYHHAPNMRLACREIRVLAAVNKTFEWLDSKSEEERHALLQKAVELAPIEEAKASLNAKNFQEAFWKHLEQERAADIITSIARTKKEKDAYEAVVSLGGVWKSVEEMNVALSDKPERVQRKAIEINLKYHKFCLKSKPDNLKRFTVSFNSKPKPLQELVSNVSYLISIASTFEYTLALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6V5</accession>
    <name>A0A914Z6V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8425.t1">
        <property type="protein sequence ID" value="PSU_v2.g8425.t1"/>
        <property type="gene ID" value="PSU_v2.g8425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8425.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23943" checksum="AB459AF89A1B98C8" modified="2023-02-22" version="1">MYELAENAKHICWNHSHYTELVSSEEDDPKRNNVVQDLIQAQLAFWTLVFSFLYSYAWQQHRKKFLGTIFVAIPLVFIVCFTIAWLLGTIVVLSRLFSTSLKIEEMLKYGKCESDEVNRRRRTLSNASKCSIISGRSSSGEELPKPVCRKHSSSNTSLNQILMSNSFSNGSRAVSPTFSFTRQISNSSPTRKLSYTYTHQTADDDEGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6W9</accession>
    <name>A0A914Z6W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6W9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8440.t1">
        <property type="protein sequence ID" value="PSU_v2.g8440.t1"/>
        <property type="gene ID" value="PSU_v2.g8440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF52">
        <property type="entry name" value="PAIRED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="8">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8440.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17892" checksum="FB920663CE98B4D2" modified="2023-02-22" version="1">MNYAAKCDNQNPFYDNIGESARNRFGRPYISGRPLLSCDRERIIQMFHHGVRKIEIARALGVTHSCVSKVIRRFEQTGVIDVGKQSRTASCACPGESSQHNPFICRHLKYKLNNSKCSKKTELFNDKKQLPKVFTIEWILSDLKVNTQKTDDTLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z767</accession>
    <name>A0A914Z767_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z767"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8168.t1">
        <property type="protein sequence ID" value="PSU_v2.g8168.t1"/>
        <property type="gene ID" value="PSU_v2.g8168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8168.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7702" checksum="1A82A8DDA41786A4" modified="2023-02-22" version="1">MLLIEFELFPFVGEEIIELVLRAAAIVMGDKVADCRLPDIDFREPVLAGGAVVVVAVVVVDDGRGTGGCCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z823</accession>
    <name>A0A914Z823_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z823"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8051.t1">
        <property type="protein sequence ID" value="PSU_v2.g8051.t1"/>
        <property type="gene ID" value="PSU_v2.g8051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="535"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="195"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="394"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="694"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="870"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8051.t1"/>
        </source>
    </evidence>
    <sequence length="1095" mass="128172" checksum="2889DF1582D983A2" modified="2023-02-22" version="1">MHLKTININGFRSYYEKTTIENFSKQFNVVVGQNGSGKSNFFAAIQFVLGNEFTNLTSDERKRLLHEGSGSRKTTSATVELIFDNSDQRLSAFEGNEFSLSRTITDKKDQYFFNGKIVTKSEITNLMESAGFSRSNPYYVVKQGKIAELAIGDDKSRLKLLRDVAGTRIYDEKKTESLKMLDETKEKMDKSVLLLELMDKRLKTLESEKEELKEYQKSDKLRRALEYTLLKTEVNDCKKEFDNLSKQRQELQATLNDVEKLKFDDSKKLSALENDRQTFEIREKRLSAELSSIRDEEQQLESDRALTTLESKDLEDQVNQERDGREVAQQKLEKLQEDIEIKEHELEEIRPRYKKMVEEQAEIFSELNNIKRKRGELLAKIGGEKGYSTAAERDRALKEKILLLNQRIEDLKDNIENFSKAYDNDKIMKAETDERIQEIETKIEENITRMDELSNQDDTLRQQIDAATRIFHEKQLAHKEVTDQLAEQEAQFSHIETSFYRMLPKSVSEGIRNMNTIMEDLKQRNTNGKYNEYINGYHGLVIKLMSAENTYFKALEVTAGSTLTHHVVDNERLAMFFLDEINKRRMTGQCTFFALNRVYAPDQRPLRDRDGRHLLSIVKYAEKFSSVFRSMFGSTIIVKDIKTGRKIARNERFNCITFDGDEINCSGPMTGGYVDSRKSRLDTMKNLQRFEPTLVELKKRSQVLSKECIEKENELSDLRMKLFNNKQERESLQREHNNITEEKRELFELNNRFRRNMETKDREFIEHNHSLHELETRRNEMQAQIGTPLTKRSDSQEAKELIEVEALFKEQSAKAEEILNKVSDLQVRKNGLENELGSKLYRQREDLKMKVSTINFEVKRHELQTRSVEAEKMQRRIREIYERNKEVTEELENIRNSINECRGKLDLLNDEKLDADARVNSCAADIDIIRRRMAECNKRREETLNRIKDLGTLPVDITTRYGNMRRKELETEWKNSLNQMKKFTNVNKKALDQFVRSTAERDNLHIQIEEMQNNYMRIHALIEASQTRKNDALYLTFKQVGKNFHDIFKKLVPIGVGNLIMKTTAVDENDPEAAERAHTSHVMERFNGIGIRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z932</accession>
    <name>A0A914Z932_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z932"/>
    <dbReference type="WBParaSite" id="PSU_v2.g833.t1">
        <property type="protein sequence ID" value="PSU_v2.g833.t1"/>
        <property type="gene ID" value="PSU_v2.g833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g833.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8248" checksum="95C53AE00D0D4E3C" modified="2023-02-22" version="1">MTGDGVNDAPALKRADIGIAMGSGSDVAKQAADIILMDDDFSSIVHGVQEGRLMVENIKKLLAYIAAHCVPEFWVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9C9</accession>
    <name>A0A914Z9C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9C9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8418.t1">
        <property type="protein sequence ID" value="PSU_v2.g8418.t1"/>
        <property type="gene ID" value="PSU_v2.g8418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8418.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8223" checksum="811C5D454FF683A9" modified="2023-02-22" version="1">MYANVYRIMWSLEEKLRIATKRFSDRKLGDDIMAQIRRMAPYDATRNNQEISTMLKSVYQSQNQGQPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9W4</accession>
    <name>A0A914Z9W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9W4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8588.t1">
        <property type="protein sequence ID" value="PSU_v2.g8588.t1"/>
        <property type="gene ID" value="PSU_v2.g8588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8588.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8101" checksum="7F32AA14E1DE4665" modified="2023-02-22" version="1">MDAYWARYSSIYIDNEFVVTAIDRKCSLLHQIPLKEPLKLSFLAWTCALNAGLIQQNTNLPPKLPYSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA53</accession>
    <name>A0A914ZA53_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZA53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9202.t1">
        <property type="protein sequence ID" value="PSU_v2.g9202.t1"/>
        <property type="gene ID" value="PSU_v2.g9202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000027">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="146"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="324"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9202.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47681" checksum="C4FB0E859444ADF8" modified="2023-02-22" version="1">MFKKEADGTNTTVPNDLVEKLDKLTIEDLKSLQISQILTARATIEENITKSKERVEQVENDRNSKLALIGNLLHESVPISDNEDNNRVERTFGDIKSRKKYSHVDLVVMIDGFDGERGTAVAGGRGYFLKGALVFLEQACIQLALRILLKKDFTPLYTPFFMRKDAMQEVAQLSQFDDELYKVSGKSSEIAGDEAVDEKYLIATSEQPIAAYHRNEWLNPADLPLKYAGVSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVICSPLENESWTHFDEMIANAEEYCQALELPYHVVAIVSGELNNAAAKKLDLEAWFPASGAFRELVSCSNCLDYQARRLKVRYGQTKKLNEDTPFVHMLNATMCATTRVLCAILENNQVEDGIIVPKALKEFMPEKYREKIPFVKPAPIDEENKKKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAA4</accession>
    <name>A0A914ZAA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9591.t1">
        <property type="protein sequence ID" value="PSU_v2.g9591.t1"/>
        <property type="gene ID" value="PSU_v2.g9591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9591.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20339" checksum="9C54D99AFEEC8F3C" modified="2023-02-22" version="1">MRADGIRNPMVRYFNRDRNSPPFVVMMDSTNLKCIHMATDLTFDGTFQYAPNNMPNSQIYTMHATYHQLPNFNNNFLVGIAFVQNKDIPTYEQIFNVIKEQLIAEFGDIGCHKTIHMDHEIVAITAARRVFPDWTMHSCYFHFGKNLRTKMGQVLLDTEEVGKWFSALCGNYQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAM4</accession>
    <name>A0A914ZAM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAM4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9371.t1">
        <property type="protein sequence ID" value="PSU_v2.g9371.t1"/>
        <property type="gene ID" value="PSU_v2.g9371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9371.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24429" checksum="40A18092D152E56E" modified="2023-02-22" version="1">MADAARIRNIHGDDIPSSIVSRLTATRASRRNSIGQNSGDELQNSLNALKNFVADPTVTDKNSAISKYRARNGNPMDAISSDPRPTAGFTNGPPILPGSVKPYRTSGYGKTLTEAQMSESYAGTPSPLQTMTTISTPMSRSYSPNRSGSSLFEKTNNNISPRTSYRYPSYESVYHPPPSEPLFRNKGQTIIEEIQERWGESSRSRRFPRSSKERSLFCTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB07</accession>
    <name>A0A914ZB07_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZB07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8945.t1">
        <property type="protein sequence ID" value="PSU_v2.g8945.t1"/>
        <property type="gene ID" value="PSU_v2.g8945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8945.t1"/>
        </source>
    </evidence>
    <sequence length="468" mass="53323" checksum="31BFF3D946E9E203" modified="2023-02-22" version="1">MFKHLTGFAYNPSHVFHKNTVNQNHPENENRIKLSLNRIRQIQADKYVADYTDPSVHNEQLDFSLTDYILQEIHDDGYLQTLKKLEKMSQTEIDDLCRSFDSIAMTPESFKVAHEAAAYCVTLTKKVAEGELKNAFALVRPPGHHAHDDCPQGFCVLNNVAICSQLAIEKKYAKKVLIVDFDIHHGNGTQQFFYDDERVTYLSIHRYEHGNFWPHKRYSDYDCIGRGTGRGHNINIPINENGGTHHDYLCILFTIVIPFARELQPDMVFISAGFDACIGDPIGYMDVIPEIFPHYIYQLAPMCNGKIVAILEGGYNHSAVAVCVDMCLRVMIGEKPPYFKYNKVPRASTVISCMNAIGALREYWPYVNSFYDLAPYVAAGHQSVLPIFHDHFGISTTHTGNINQNNLRNLLNSHTPQIIKLPTTKLFNINMEFPMFNVKNIPVDPHANQYEDLFSVSSKLQLKNYGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDU6</accession>
    <name>A0A914ZDU6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZDU6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g985.t1">
        <property type="protein sequence ID" value="PSU_v2.g985.t1"/>
        <property type="gene ID" value="PSU_v2.g985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g985.t1"/>
        </source>
    </evidence>
    <sequence length="642" mass="72566" checksum="FF70FFA89701FBC1" modified="2023-02-22" version="1">MNSPAVIICAPTVGIHVDHFYPLTGDRLDALRNQTKHCKLLIIDEVSQCSNELLAKISLRFQEVTGIDEPFGNVPTLLVGDFLQLPPVNAQFCFEILSASVIKKITDSGETSYDLWSALDIHYLELYINKRQFNDLVYADVLGRIRIGVLTDEDYDYLMQQVVSIEEGKEKDTCVQELYHDLAAIDPTSLMLYSNNQMVDNFNKRYLLTHFKSVLVSIPPIYVDIESDDNENNSDSDKLVKRKRIRPRVYQQAKYQLNRTQKYSAPKPKRMKYVATLCKTIHIAVGVRVMLVYNSDLKNRLVNGTIGTVVDLKYSKKDTTKIISVMVKFDNIKNVVPVRRIAITIKRDAEIIFKQFPLTLAFSTTIHKSQSISLSTAIISLEKVFAPGQAYVALSRLQSVTGLYLLNCPKEAFICNQKALVELDRLRLTAGLPPRQPTSTWKHGLKARRKSEFEIRHIVVPKRARRMSIPRQPPTSHESLGLLQLRNRGTDCFIIAAVNLINITAGLKLAILNDDEIDVNVMANVHLVEILNGGANHVIDLRNDFPLFRNIQNQESAGHALMLIMEQLSNDVKQCITFLSTKFTSCLCDNGNARQSLVNHRKTLLQLNARAHVVNTLNTMVENYVREAPDVPCASNVIYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQ78</accession>
    <name>A0A914XQ78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basic proline-rich protein-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XQ78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10174.t1">
        <property type="protein sequence ID" value="PSU_v2.g10174.t1"/>
        <property type="gene ID" value="PSU_v2.g10174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037081158" evidence="2">
        <location>
            <begin position="17"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10174.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="32384" checksum="45C1FD055CDE50DA" modified="2023-02-22" version="1">MVRILCLLYFIGAASAFNLFGGEDKPSNGPLIMPSGAPPSGAPPSGLPPTGRPSGPPPSGAPPSGAPPSGPPASGAPALRVKRQAPSGAPPSGLPPSGKPSGPPPSGQPSGLPPSGAPPSGAPSNMRPKRQAPSGPPPSGSPPSGAPPSGLPPTGRPSGAPSSSQAPPSGAPSGLPLNVRPKRQAPSGLPPTGQPSGTPPSGAASQSGKPSGAPASSGAPPSGAPMRPKRQAPSGAPPSGLPPTGKPSGPPPSGQPSGAPPSGAPPSGLPPTGRPSGSSPSGSPPSGSPAIRAKRQVPTGKPSGAPPSGLPPTGRPSGSPPSGSPPSKAPPSAVSGRPPVSGAPLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQJ4</accession>
    <name>A0A914XQJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XQJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10278.t1">
        <property type="protein sequence ID" value="PSU_v2.g10278.t1"/>
        <property type="gene ID" value="PSU_v2.g10278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="59"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10278.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27455" checksum="D694BDA5A6014A59" modified="2023-02-22" version="1">MQLEPIVCLESNEANVQSMEFALPETAAITADDMINCLLPAVKDILKSHQRDGIKFFFQRIIVEKSGAILAHNMGLGKTLTTLAFLYATLELYKKQILKVIIVVPVGVLRQWNQEYEKWFGNSSSIFVMDEKPSTRINTIFEWISDAEKNIMIIGYTKFVDVMHDVNGATALQSINLIVFDEAHKMKTETTNVYKIAEMVTTPLKIFLSGTPLQNNVMEYYNMMQLISPNILCDREEFKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSL2</accession>
    <name>A0A914XSL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSL2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10967.t1">
        <property type="protein sequence ID" value="PSU_v2.g10967.t1"/>
        <property type="gene ID" value="PSU_v2.g10967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037378721" evidence="2">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10967.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30345" checksum="ECB20F6C8EDC93F6" modified="2023-02-22" version="1">MNKLIYIFSSFIIFVNCNPGFTYYTPDTYPDSQRDYQLCKLSKPGLICDPNEMLGDVTNLNSTAADYIDPMLTEIQKTTNCSCQDFDQCFITPFGKQGVTISVALLKSISADNIPEEQTPEGRLHLIQNFANALRNRQQRGSCDDDILIVITPEMIYTAVGTGTSPIISKDAIDKVDKIVLPYLQSKDYTRAIVEMTRMYSSALKGEDSGKIISKPWYSPLPLWSVYAIGGGILAVIIVIILVIIMVLKRKQKTRGYSVGSEARRNGQNSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTA9</accession>
    <name>A0A914XTA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10503.t1">
        <property type="protein sequence ID" value="PSU_v2.g10503.t1"/>
        <property type="gene ID" value="PSU_v2.g10503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10503.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30393" checksum="81ACDD47FA57CB00" modified="2023-02-22" version="1">MSLSTGSSSSSEDISFKPLKEKSSSLPYSLCCTSVKSFCCPKIDVAAEEGKEQLQNGADLKWFKEKTSQLPYIDDGASTVSAWSSVLELQENNVDLKYLPPKRGVRFNTKAIASEEDNDKSFSMPRKKRSFLRAIAKHLPRRRSLHPSWKDIDVAIYAKNTIEDDAHPLNCLIRRFGECRLDGNCNFIYDDPAEEEYIVKPDELPEAQEDPDYFPGLAQAEDDPANNSWDNFHWNGQDKPSMVDVNANGPKTFWCNDQWNHNEFDAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTU4</accession>
    <name>A0A914XTU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-type ATPase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTU4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11378.t1">
        <property type="protein sequence ID" value="PSU_v2.g11378.t1"/>
        <property type="gene ID" value="PSU_v2.g11378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF215">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="5">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11378.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12912" checksum="C393243E60F9D2FD" modified="2023-02-22" version="1">MTPCEKETVVKTVKKYLKGKVLAVGDGANDVPMIQSADVGIGISGQEGLQAVMASDFALARFKFLKKLLLVHGHWFYYRLANVLLYFLYKNAMFVFVLYWAQFYSGFSANGIMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV28</accession>
    <name>A0A914XV28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XV28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10823.t1">
        <property type="protein sequence ID" value="PSU_v2.g10823.t1"/>
        <property type="gene ID" value="PSU_v2.g10823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10823.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10430" checksum="996EC268CA60B212" modified="2023-02-22" version="1">MARLGNAMQALVQSVGKSETAIIFITDTSSEFDINKALGLYNAILKNHTKLTFILAGEKAKAENLAEFNATIFDWKNMDLEKPNNWNAFKAFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVC2</accession>
    <name>A0A914XVC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">LisH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11886.t1">
        <property type="protein sequence ID" value="PSU_v2.g11886.t1"/>
        <property type="gene ID" value="PSU_v2.g11886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11886.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13248" checksum="69CD0F1918927600" modified="2023-02-22" version="1">MSFSKDQHHTFITQYLRVYGLVPSESQGPVNKFVDSYLRHDGVFLLRLIASNAGDLITTDLVYHLWQQFLQEEAAKAETLRLPRSEKEAPLRLPHAPPPIDDVDTNNFDEKQRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVR3</accession>
    <name>A0A914XVR3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XVR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12026.t1">
        <property type="protein sequence ID" value="PSU_v2.g12026.t1"/>
        <property type="gene ID" value="PSU_v2.g12026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433795" description="glucuronosyltransferase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12026.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26809" checksum="57E62E146FFBD78C" modified="2023-02-22" version="1">MIWKKAALIYLSVFLFAEFSNAYKIAIFTPDISASQLILNKRVAETFAKAGHEVKMFRIRAMGYKHLEVHVDQKAVNVADIIAYSDEDFDAFHKIQGEFYFSELSVFSSKTRDSYHRFADLFTNSCAELLQMTSFMLSLQEENFDIAFAASNDYCSIGLIHAVKIPTWIWLDSGALTDFVAENIGVTSPSSFVPLEFADSGDKMNFMQRFFNLVLRGGFPYLYDRFGKNFLKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVT8</accession>
    <name>A0A914XVT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Laminin G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10644.t1">
        <property type="protein sequence ID" value="PSU_v2.g10644.t1"/>
        <property type="gene ID" value="PSU_v2.g10644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="69"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10644.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27600" checksum="4BE4F847074A6B75" modified="2023-02-22" version="1">MLNVAEPLQPYENESEESISNDDFDGDIIKATFNDIDLLEEVRLRQKDRTSSEERSEGQRLKHRKVKSTTVWFDTNEGHLAFSLYRNTTQNGIKLALKFRTLSKKCLIFIIWNEKVVGNEQISLQLINGQLRLTRISGSQLSTSTIKGKRWNDLKWHTLHLIETSKGGLKASIENKSAEIDGTLPTFRSAGKLFLGGLPTGTSWPQGIPQSEGFRGCMAALKFGNELLDLWSDAESGVQVEKGCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW96</accession>
    <name>A0A914XW96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11234.t1">
        <property type="protein sequence ID" value="PSU_v2.g11234.t1"/>
        <property type="gene ID" value="PSU_v2.g11234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09737">
        <property type="entry name" value="Det1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11234.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36318" checksum="0DD4EFA36487C03E" modified="2023-02-22" version="1">MKSNEVKPLQGKVARTFHEFAKRRKFTGTYDKSEYDGPLDPYLLINSFRTVPRVDSPPVIPLRFTHNGKMMIGAMEQPPNQLIIYKYMGVESLAGVQPNDMFYTIFKHLHIINIDESGRNYRLHKDALFLLEDDDFLITFSSAQVMQQNNNNNNEQESVVVPSLPLALVQQNNETPRQALSTMDHYIFHVVSLKTGKVVHKIELEYHWLISSHCIYLRKRTFIVLSIHHQTLYIYNVTKEGKLELITDIGEFIEPPDQRLSRPGQVNDAFTGIKQLLMKSLFEFHKNDGNIQQFFNFHIYIVHLKWFECKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWP6</accession>
    <name>A0A914XWP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g1237.t1">
        <property type="protein sequence ID" value="PSU_v2.g1237.t1"/>
        <property type="gene ID" value="PSU_v2.g1237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002832">
        <property type="entry name" value="ABC Transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="754"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1237.t1"/>
        </source>
    </evidence>
    <sequence length="1481" mass="167241" checksum="77A04B60B7505C00" modified="2023-02-22" version="1">MINQLQTDLGLSKIQAEKFKNISVTPKFFGNAFYTYQKLKNDKSTSFLELLLEDKEIDLFCNETLVKESFVSVNNEVKEVGLCNISYSSFLPLLISDNGNFNRYKIIPEIATIILSQAAAAAPNSNNNQQKMSNSKINELIASLNETIGKFPPFDFGPFFGDNEHLLDAIFCGNFLSSLQHSTGQPQIQLNTLLDNFQKKVQEFVMKLTPGQSHSAGGINKCGDMIVQKNKACDILNFLSVGNTAGIKTMFNGHILVSPDVPITRELVRRLNQPLLKLNYFRDLIADFVQASTGLQDEISKSDLQKAAKVLTWLLPSTGFNRTAGISNILQHLFQNSSDPKSLLIMAKHFSNQFLNVSNCFRMDRFRFMKNEKELEKQAMCLSNYDMYFSGIVFPDNITNNATDELSPYTEYKIRHNHDLIDGTDYLIDRPNRYISRDSPFRDLKYLTFGFSFLQEATEKALVSMFTNETISEGIYAQQEPYPCVQQDWFNVTVFLSLFLILSWMIPSALLVKNIVWEKEVRLKEMMRIMGLGDMIHFLVWATQDFIFNLIAILIICVMFKFGNLLPSIDFSLILIFLILFALACIAQCILLSTFFTRANIATASTALLFFLFFVPYQLSVKARSPTFTLITLILPQTGVGYGMTMIALAESSGMATWDGIYNIELDAYHVNLPKIMIAFIIDILIYTILAWYISAVFPGTYGVPQPWNFFIKKSYWYNTYHDNINDEGADKEPTPKSLENDNFEEEPDLPLAVDIVEMDKVYGNHTKALDNLSVRFYESQITAFLGHNGAGKSTTISILSGLFTPSRGTAYVYGKDIRKEMPAIRDNLGVCPQHNILFDAMTVEEQLRFYGSLKGLIGAKLDSEVEEMLVDTGLKFKRSALSTALSGGMKRKLCIGIALIGGSRLVILDEPTAGIDAHARRSVWSLLLKHKRNRTMILSTHHMDEADVLADRIAIIAEGQLKTAGSGLFLKRRFGNGYQLTLARPQIRAEDPSATYLPNSSGISSDHSEIAEFIKINSSNHGILIGDVGTEITFNLPLNMEPEKMEQLFDQLDKEKINLGIESYGISAPSLQQIFVKIAPAHDLKLKKQPGRSVWSSIQGIIAKLRRRTAQVGNEIDGNATTAEAAEGIQLVNDGNERDQNHPQVLYIEGSSLSVQHAYALFAKRWQNSKRTLLQLFCLLICPILLLLFAEMYAKLQKRLGSLSYDVWEQPLYLTPVIYGNYTEVYFGIWNRNHSSLQYLESMMENPGIGDRCMKNISLFNETDVRCIDGYAQGKLNIQKDDPHKISYNVPQKCGCTPNSGWNCTDGDYPLQSLQTFTLNTTDRIWDLTYRNISQFRLVTFKNTTGHREVILGGFTFGHENIQSMTVFEERDTVLGLETIVASLKNASILWNLNWKNATDGINWTTNYDPFLPPKMTPKSFIEQILPSLDTEENSKIWFNNKAWAALPINTNSYHNAILRALRPQSYLPEEIGIMTIVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXV1</accession>
    <name>A0A914XXV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11357.t1">
        <property type="protein sequence ID" value="PSU_v2.g11357.t1"/>
        <property type="gene ID" value="PSU_v2.g11357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11357.t1"/>
        </source>
    </evidence>
    <sequence length="1130" mass="130155" checksum="0063AC5EB198C6C1" modified="2023-02-22" version="1">MDSSLNSLRIFYNQAVFYRRNQTEKQFIFDTINKEIVEIEKECKKIAQTIVDLNNQDTENNTTTTNNASKEMEANSSQMSSFYSQSPPLDDQQQHRQESASFSSSSSKETILESPFINSNSASHDQLTYNPTEHQHIEWYVDEKQHSHHINPIDEFTQVVYHQKLIETVKTIVDNALNEHHSEHRVHSTKSYSGETTTHSSNHSAKSDGFYYDDHSDINKYDSHEAYQHQNGGNRSPVSHFYEDNEALFDVHVNANSRVSRDTEMDAIVEHENESFPPIPKTSFTDIYSKYPQENNYYEEENSTQQSIPEIILSTPPNEPPVESDEEGEEFIHNETEKDANTNDLFESTITVDYPIMTKSEAGEVTEITLDATIVLSCKSLVEETVPLEPWATVNSRTFEAIVEKRPEPVYVEPELESESEPEVQEYVQAPQPRYSPEPEPEEEPEPELEEEIESESSESEPEQEPLSARSPSPEIQRTPSPRYHPQRVYNIYEDIEVETSEEVLKGRRVKGNGYDYFKKIERDEVKDEGIYESSTIRASTDYGWQIQSPPIAESPVDNRTPSPAARHIFPFRHMGLDLSKDNQFVYESVSRVRSIDTPPIYQKSTGHSQSGAFTYPKSNETMVRSPSPTTDIPDNLEQSYNYQSSLDSKKYYQRSRMVDSPAYTPLSPFEEARILSPSQKNSTEYSESHFEIHRSSQNKAVEHQPVYSKIFTIPQSHQNDQINIPDRHRYSHEEEEEENYRNQQKPHVRPPQNIHQSYAPQNKTLLFDENADVDKNNELYKAKAFKAEREKVTSGNRFEKDNQHVEVINVKKSYEDQTDLHKHHHHHHHHHHHHPKTEQVEHRDEHGSHDGSVESQTKIGRKYVVDNSKQRNPSWQKIQPQPTERFTLQSSNEFSSQKHQHEYHESQPIVKEHHIETITTVHSTTSTSKGHPNLRVHLTNSNQVHQAVTKAAENKFINARIPHSPMITPPSTPITLEPETDVPAPKMARGIFKNLERSVAEEVRREQGSSSAFKREQDALDAKKRLAEDSLQHPGRKPKGGHILFGGSCHSYGDSEPDETKNEESVLSSAQKKYSFDQSNSKPKSVTFATEHQEHLYDVNYYHETSSSSSKVVKKTEIIESDNKYSLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXV5</accession>
    <name>A0A914XXV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXV5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12778.t1">
        <property type="protein sequence ID" value="PSU_v2.g12778.t1"/>
        <property type="gene ID" value="PSU_v2.g12778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12778.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7725" checksum="37C928E6FA63C4A6" modified="2023-02-22" version="1">MVFIDSMGFEALLEVTKTAKKHNTKLIFAAFPSSVLSVFENADFYKDFPQENIFPSVHHAVQYLKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXZ7</accession>
    <name>A0A914XXZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12074.t1">
        <property type="protein sequence ID" value="PSU_v2.g12074.t1"/>
        <property type="gene ID" value="PSU_v2.g12074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12074.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13717" checksum="4F2EF4F26C00BA4F" modified="2023-02-22" version="1">MTKCYILVQYYAVLNEVFQTIDSREIFSPSDYVCSTPIRAKIELFDHNTGFPDSLLLTKEVVKNIGYSLEWEERKIFNLDPYLKFKVECPGGLSFEKEFAIIGHNPFTVMQSYKIDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0Z0</accession>
    <name>A0A914Y0Z0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0Z0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13875.t1">
        <property type="protein sequence ID" value="PSU_v2.g13875.t1"/>
        <property type="gene ID" value="PSU_v2.g13875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109:SF3">
        <property type="entry name" value="RING FINGER PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13875.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24134" checksum="64249E6BA4428FA5" modified="2023-02-22" version="1">MGQNSSKSPLAASLLIDYDELLELINEINRKCFETAGNNPDEKYLCFAIKKGSTETFLWKATVRICCFTKTFSDTNKNIKTISGRTFTLRQFLRLYQAIKPLLEAAHDGSNLNQMFECNDLMSASIFQDSCTNEGECVICLEREPDTVLNCGHAYCSPCLDDCRRHNQKCPLCRVGSTYEQDEWVVPKMPEADTIKDYVVTLSTPSVSQSFSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y193</accession>
    <name>A0A914Y193_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y193"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12993.t1">
        <property type="protein sequence ID" value="PSU_v2.g12993.t1"/>
        <property type="gene ID" value="PSU_v2.g12993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12993.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14524" checksum="0970789F32F9651A" modified="2023-02-22" version="1">MDPNSNSNSDTESPASGIHFDPHVTETDHQYENLLKPKVHPPIATADKIGAQLYNNPEAADTVRKMVLLGNKIDIYYSNIVFCEDLTAKTITAFLESQKANVRFTLESVDPAFAATVIDSNIAWKGFFNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1P3</accession>
    <name>A0A914Y1P3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein MAK10 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1P3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1270.t1">
        <property type="protein sequence ID" value="PSU_v2.g1270.t1"/>
        <property type="gene ID" value="PSU_v2.g1270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1270.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28206" checksum="E654769D6983F2F7" modified="2023-02-22" version="1">MDLGMIPMDETLGLKYAVEKKYFNEKIFSAEEMIAIFDASFACIASSIDGAYFDQTVIIILFDLGGIAFEEDYNYQCLRDQQTLKCNNMEIINELKSIYQKLSKYQPGAAEYSYGQRIKFLFSLFEALHYMIASPEIMSVDSTLSFEVNFKLAESNMEQTLKAFQVVKDTVKQGFQPGDGNDNNFSWLSVFQPDVNRHLFAASFPKEARLMNRQEGYNFLEKTLTFLKKFTIELPDHAKSVESLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1Q2</accession>
    <name>A0A914Y1Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 35 member B1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1Q2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13156.t1">
        <property type="protein sequence ID" value="PSU_v2.g13156.t1"/>
        <property type="gene ID" value="PSU_v2.g13156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13156.t1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41372" checksum="FFD56CC31AC858DD" modified="2023-02-22" version="1">MVAATVAVANESFMKQVLNALISGGGVVFSYTVFSILQEEITRDTYGPKKEKFIYMQELVFVQCLAYCFVAFLCKPRGSQIKESVPWYYYAIAAASYTTAMVSSNSALKFVPYPTQVLCKSCKPLPVLLFGVLFASKRYHWRKFLYITLIVAGMAIFMYKPKHSGKFDVLNFGTGEALLLLSLFMDGVTGTVQERMRSGYKTEKYSMMFYMNFFSGVLLSGSIVFSHDLFKFIDFVQRYPFVLQRIALLSIAGACGQVFIFKTVSDFGPLTLSIITTSRKLISVVLSVILFSNPLNQNQKIGTIIVFLALFLDGLDSSRRSKSAADAASVEPLKAKKETPDASGEEEDGFEKVPKAKAPTPPKKRQAVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1Y5</accession>
    <name>A0A914Y1Y5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1Y5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14194.t1">
        <property type="protein sequence ID" value="PSU_v2.g14194.t1"/>
        <property type="gene ID" value="PSU_v2.g14194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14194.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20127" checksum="CCCD454B2298871B" modified="2023-02-22" version="1">MVIAIFIFDDKGRAGNHPVAIPLQVTTHNGFQIGMQHFQLTDVDRIRIQSTCCHVAQTPLSISSPEGHTGRGQISPRWRPIAQTCCFYRMGIGTNRHAIGMRDTRLITQGNPACSCLRGRARIHQRFITNRNAADVIATTVAIEPMATEPVAPERERSPTATALEALTGGATGVPEPVSPGKLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2U1</accession>
    <name>A0A914Y2U1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2U1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14497.t1">
        <property type="protein sequence ID" value="PSU_v2.g14497.t1"/>
        <property type="gene ID" value="PSU_v2.g14497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF21">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="138"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="351"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14497.t1"/>
        </source>
    </evidence>
    <sequence length="533" mass="59148" checksum="212764103D3D5670" modified="2023-02-22" version="1">MPLKHKSSNVEHRKSMLSSVLSETHISQSELNIKKSASKSEINKSAVEQNSLPMLEIKENDSLKGSTCDTLKDLSLAKTQPSMDLRDISHESVLTFFLQSLPPLIFASVGLIGTGVLLDKWQCDDFYTRIHEALMLTPALLGLKGNIEMTFASRLTTLSHLGKMDNKENCLSILGSNMALVQIQAIIVSYFATTITVITESVRNDFSFQDSHILAASAISSTTASSVILCLLIMGLVVIARKLKINPDNVMSPLASSMGDLITFLFFVGFGTLQITCCSVTADSCWLSIIILTISIFAIPFVFYFAYRNIFTRQTLIWGWFSVIFAAIISSAGGYILERSALKFKNLAMFQPILSGLAGNRAAVQCSRLSTCFHISCERLGVVDPKDTLRRRLNPWYTFNAEDIHSRTALVLIACTVPSHLLFMSIIIAIGGAKKYILFNWQFFTSYCIAAFIQVVILMYFAQLLVYILWRIGTDPDHSAIPVLTSIADLFGVALLLSIFEFLSEFSPESIGKDVNQIFKERSHCIINETNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y321</accession>
    <name>A0A914Y321_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y321"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14581.t1">
        <property type="protein sequence ID" value="PSU_v2.g14581.t1"/>
        <property type="gene ID" value="PSU_v2.g14581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="320"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="485"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="527"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="724"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="3">
        <location>
            <begin position="790"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14581.t1"/>
        </source>
    </evidence>
    <sequence length="975" mass="108169" checksum="40B10C039B5C4625" modified="2023-02-22" version="1">MGKWCEQMRLSAHLNSTTNILTKQCPKGYCKNGGKCSFENGHPKCECLNSSFTGEKCEKRVAEDLCNPNPCLNDGQCHSNGTTVSCFCLEAFTGSRCEIPCKCGTNELCRESIRSPGTAECLTVPEPELIIPDNNNFSFLETTNQIDDDETTIITESQPSTTLTNFSLPSTTLLTQNINNSNNSFEVTPTTIVSPSSSTSFEIPTTLKPLTPIPTTTTTFNPNLISSSTIITETDTFDELLNVTSCDSCVNAQRCLEMDNRYICLCNEGYTGAYCDEPSNVCTSISCKDGQVCRLQRTGSIDLPQCACAPGFFGISCHDATTASFKPSSILIYQSQSKPLKDSEYSLILSFRTTVPNVHFVTGENLFGKQQFSLSLHSGFLTISIGNTQTSINDLILDDGEWYTIWFNSSQTRITVEIEESASGYILTRKQLQIKPINIYTTRFGRINEDESSFVGCLRDVFINQQLVDLLSSDRSVDIEPGCNRKDQCKSDTCQNGAKCIDLWDKFRCECVRPFLEPMCVNQLQEVTFGHDNISSLIEFSIDANDSKLIRQKTDISFLIRSKNDDGIIGFFGNRSDDDDSVGTFLSFEIIDGKFVVNGRLGGKRIVTEKSEKSINDNKIHLIEIQRSGNDLRLKIDGKQEAILQFRHPFEHPLLADSLVLGDRTSIKQEAAFTSPSGKHFKGTLQDIRINGKSVILADDPPTFNLESFGQKQIDQNILEGTVSDDICAQLNPCQQGKCFNTFNDFECQCDSGWIGLKCEKKDFCIDKPCPFGSTCENSHGGYVCISTASFYPTSVVKYSLKLPEIVAPSKAYANFTIQIRTRSKIGQIFKLQSSLDSISFMLTDFGIDVIYSNSTNSIRDPLALPISDGQWHTFSLQELNSKLSAEFDTFPSTPLLAPFSLTRFGIDKNARLVLGKGFNSTGFKGCLQKITFNDFPEISFLPKDTFSGNLNTVLHFVPIQRENIQSDGCHSTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y347</accession>
    <name>A0A914Y347_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y347"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13202.t1">
        <property type="protein sequence ID" value="PSU_v2.g13202.t1"/>
        <property type="gene ID" value="PSU_v2.g13202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF240">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13202.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17078" checksum="AF5CC0F86A6B34A1" modified="2023-02-22" version="1">MVVTFFITLVVLFVSLSNKSIAVRAAFDILAAVLFINLCWFSIDLVRGVIFKPRLMSKEIPEEWGKNPVKVLVGKNFEKIAYDQSKNVLVEFYAPWCGYCKSLAPTWDKLAEKFKDHENIVIAKMEATTKEPKKLKILKCNISLGSVVSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3C3</accession>
    <name>A0A914Y3C3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <ecNumber evidence="3">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y3C3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13732.t1">
        <property type="protein sequence ID" value="PSU_v2.g13732.t1"/>
        <property type="gene ID" value="PSU_v2.g13732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13732.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9549" checksum="E3F7B5C4C9454F54" modified="2023-02-22" version="1">MAETGEFDALIALGAVIRGDTYHFEVVSNESASAITQDEQAEIRAAEKGRDCARTAVELGNLIAVLEPELDDDEDEDYEDEDLDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3H6</accession>
    <name>A0A914Y3H6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3H6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14000.t1">
        <property type="protein sequence ID" value="PSU_v2.g14000.t1"/>
        <property type="gene ID" value="PSU_v2.g14000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF30">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14000.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15233" checksum="F8BF220BC76CB7C6" modified="2023-02-22" version="1">MDPLLKEETIEYPSWKANAITKLLGELETKAWILFPDAKKLASWIILSVNEKFGRQGIGRKLIEYRLDEIKEVGCEGIITEATAFKSQQLFSKLGYQNIFQILHENYKDNDKQIFKCLDETDRAILFYTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Y0</accession>
    <name>A0A914Y3Y0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Y0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13936.t1">
        <property type="protein sequence ID" value="PSU_v2.g13936.t1"/>
        <property type="gene ID" value="PSU_v2.g13936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13936.t1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39372" checksum="F6691846FDCC8FEA" modified="2023-02-22" version="1">MRRSSEEPVPPKSNVNDFDFGWGPRPEGSISPLPSGGRHHTISSGVATNGKPFKAVVQLDRETFPPPPRPPSKIPITPLSEAPIIPAALNYHSRRPTSNGSFIIRKQDSIAEEPSPNLFENDGEHFTWSRSPSPIRPPGYGFDSPDVTRRKLSLSPAATTNSLYTNVFARRKQFQREVSAAHSDVTETVTRKQMTDAATSPIPPAYSCENNLQIRFDISSGSSLAKSTSSSFGRSHSQKRIKKSSLAHSHGGSLVANGFLPASTCFLAVESTKPRIERDPTKWHLSMTKQRSSSESAFQASSIPRMMIETGLQGRRCSVMEIRDQLNPAKQNALLRKILGPSGLDFLRENTTSKQPKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Z7</accession>
    <name>A0A914Y3Z7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Z7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13500.t1">
        <property type="protein sequence ID" value="PSU_v2.g13500.t1"/>
        <property type="gene ID" value="PSU_v2.g13500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF2">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13500.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11146" checksum="65D90421E6F3762F" modified="2023-02-22" version="1">MHTIQPSRCRLYKYLSGIVHCAAQTHDNTECCRDMGLDDINNQCSMLCHPQKSPRQFWGARSLRKDLVQCLAKWDQIMTCHLSGLRARKIVKEPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4B5</accession>
    <name>A0A914Y4B5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y4B5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12580.t1">
        <property type="protein sequence ID" value="PSU_v2.g12580.t1"/>
        <property type="gene ID" value="PSU_v2.g12580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="81"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="266"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12580.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48850" checksum="09A67FE5EA9E155A" modified="2023-02-22" version="1">MSSTMEEDQLLDYDEEQTEVQAADAAAAVDGATNGDSTKLKGNYASIHSSGFRDLMLRPELLRAIMDCGFEHPSEVQHECIPQAILGMDIICQAKSGMGKTAVFVLATLQQLQPEDGTVSVLVMCHTRELAFQISKEYERFSKYLSTVKVAVFFGGMPIKKDEETLKTNCPHIVVGTPGRLLALARGGQLKLKGLKHFVLDECDKMIGDVDMRRDVQEIFKMTPQEKQVLMFSATLPKELRLIAKKFMQEPMEVYVDDEAKLTLHGLQQFYVKLKESEKTKKLLELLEILEFNQVVIFLRSVNRCQALDKLLTEQNFPSIAIHRQLGQEERLARYQKFKDFQARILVATNLFGRGMDIERVNIVFNYDMPEDTDTYLHRVARAGRFGTKGLAVTFVSDEDDAKTLNSVQDRFDVTIPELPTQIDVTSYIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4C3</accession>
    <name>A0A914Y4C3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y4C3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15048.t1">
        <property type="protein sequence ID" value="PSU_v2.g15048.t1"/>
        <property type="gene ID" value="PSU_v2.g15048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000051">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15048.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31533" checksum="63A55F2B217D4B58" modified="2023-02-22" version="1">MLGTKLRRDDEDGHERFKQMCLAEPKLTGFEFIHPPLGIDAKTFVKAHFGHNAKARNMQFAKGTTTLAFVYEPATPNDLGGIVIAVDSRASSGEYISSKSVMKILDINERMVSTMAGGAADCQFWCRVVAQYCNLFELREKQEITVSAASKYFANQLYGYRNRGLSIGSMVCGYDKLGPAIFQVSDDGTRLKLQVCSIGSGSLNAYGVLDTHYKPKMTDEEALTLGRRAIMLATFRDSGSGGNCNVCHITPKGKTRFPPIDVNHLYYEFAGEHKRDVGYQPPNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4H9</accession>
    <name>A0A914Y4H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g12639.t1">
        <property type="protein sequence ID" value="PSU_v2.g12639.t1"/>
        <property type="gene ID" value="PSU_v2.g12639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000011">
        <property type="entry name" value="Arabinose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050986">
        <property type="entry name" value="GutQ/KpsF_isomerases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42745">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42745:SF1">
        <property type="entry name" value="ARABINOSE 5-PHOSPHATE ISOMERASE KDSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="41"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12639.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="23523" checksum="11B70DD177016C67" modified="2023-02-22" version="1">MNTPALLDPXHILSSAQRTFAIEVDALQALAGVWTKVFVEATKLLVHCQGRVVVTGIGKSGHVARKIAATLASTGTPAFFMHAAEALHGDLGMITKQDVVIAISYSGQAQELVTVLTVLRRMGAKLIAITGNAQSELAQNADLHLDAHVEHEACPLNLAPTASTTAALVLGDALAVACLEARGFSREDFARSHPGGALGRQLLTFVRDIMRSGEQLPIVSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y677</accession>
    <name>A0A914Y677_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rap-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y677"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13155.t1">
        <property type="protein sequence ID" value="PSU_v2.g13155.t1"/>
        <property type="gene ID" value="PSU_v2.g13155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000002">
        <property type="entry name" value="Signal-induced proliferation-associated 1-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF22">
        <property type="entry name" value="RAP-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="5">
        <location>
            <begin position="256"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="619"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="766"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13155.t1"/>
        </source>
    </evidence>
    <sequence length="801" mass="89551" checksum="6704514A1A2628FB" modified="2023-02-22" version="1">MYFFSEWHPPYPRLCAYHDCHSLAAAWGLGPPTTTLEAARPTGASQAQSPSEDDGGDGKSNELLASCPAFRNELGIEPIRRLALSRLTINPVKAVSFDDEIETWQREHTAAEAGVLEDVSNVYLGGRLCAVRQPKIVIEPQDIGSYYFRHCFGGRSHVDYFGTDENLGPVAVSLVRETSERKEAGTIISHTLFRLIIRISDLLTMRVAVPEEALPEVPQDKSNRTLMRELLELVCPQIHFGALRPAITSPKVEELLLKIDEQPIYTRYKVGILYCKANQSTEEQMYNNECSSPALEEFLDFLGQRVRLKGFENYKGGLDTRGDTTGEFSIYTEYHSHEVMFHVSTMLPFTPNNRQQLSRKRHIGNDMVTIIFQEPGASPFSPITVRSHFQHVFIIVRVSNPCTDNVSYRVAVSRVKDVPAFGPPIGCGANYQKCAEFHDFLLTKIINAENAVHRSKKFAAMAARTRREALKDLAENYVTAHPNEGPSRIAKNLPGRFLGGSVKRKERPIPKPVLGSNVRGALSWMVDVHDHSLHKRCSCILGVSAESIVLLEIPTGAVLFATPTHSIIGWANTDMGLKLYYDHGEMLLMRCCTSDGTARELNSLLRRLEAVTNGEEAKELILRKTRPGDSLGFHIQEEGVVTDVEMYQTAWKAGLRQGSRIAEMENIAVSTMSLDQMTSLLEEKMIVRVMMIAPSSDGNPRRGCEDPNCPAIKGQEVQILTPDTFAKQPLTYQEMFKIRNKELSNSAHNSPSSSFEDRSFNFRSPVTKDQYSYRKERSTSIFDSGSEASTPGGQKEKRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7F7</accession>
    <name>A0A914Y7F7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7F7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1521.t1">
        <property type="protein sequence ID" value="PSU_v2.g1521.t1"/>
        <property type="gene ID" value="PSU_v2.g1521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1521.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13263" checksum="15EA629916BED1A5" modified="2023-02-22" version="1">MIIRGGVNLYPAEIEQYIVRHPLIADANIVGVPDEKMGEELCAWIRLKPGAILSEEEIVEFLENRISLSKIPRYFLFKTKDEFPLTPSGKIKKYELQKISIKELNLENVVPYCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7R0</accession>
    <name>A0A914Y7R0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">39S ribosomal protein L30, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7R0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15490.t1">
        <property type="protein sequence ID" value="PSU_v2.g15490.t1"/>
        <property type="gene ID" value="PSU_v2.g15490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15490.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22823" checksum="0AE8E4748492893E" modified="2023-02-22" version="1">MAKVIRSRYVFKPNNRWNRYLPRRLDGRIREYDYEANDAAPSQFPDPSTEPPSKLWLAWLYKDPKNDIKWSRQHVKNLFGDNPEAGRMHIFKNTSAVNQELWKIKHMIELRPLYFPNGEPTEADIGHIEVHPDGRCVIDKTLSTADEEKMRLLDSSKQFTVKQFANKLQARYHNFKDVYEDTVYNPKNISIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y997</accession>
    <name>A0A914Y997_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y997"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15855.t1">
        <property type="protein sequence ID" value="PSU_v2.g15855.t1"/>
        <property type="gene ID" value="PSU_v2.g15855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF310">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15855.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="29601" checksum="5DE5F48B19133BBD" modified="2023-02-22" version="1">MSSYDRMDDSGVKNRQAEAEGLRTIAFFGVALSTIATLVCVLSVPMLYNYMQHMQSVMQNEVDFCKSRSGNIWREVTRTQVLGKVNPRVARQAGYGESSGVEGGVASGSAGGSGGGCCGCGVSEAGPPGPPGPDGSDGEDGAPGEAGNDGADGPAATAQPQVDWCFECADAPAGAPGNAGPKGAPGNAGAPGAPADGGQRGPAGPPGPAGPPGQAGSNGDAGAPGQPGVVNDVPGPEGPAGPPGPDGQPGPAGPAGSDGQPGQAGGEGAPGDAGSDGAPGNPGANGENGADGETGAGGECSHCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9E7</accession>
    <name>A0A914Y9E7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9E7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15389.t1">
        <property type="protein sequence ID" value="PSU_v2.g15389.t1"/>
        <property type="gene ID" value="PSU_v2.g15389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15389.t1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53402" checksum="EB9C9C8A19414989" modified="2023-02-22" version="1">MGRKKRRERRDIPMFRIPPVDLTKPRVQNLDLFANFFNPPTIYGNPPISTIPFTPLLRTTPSNIRVINSNPPDLPPQKTINSVTTRDEMIKLFVLNGYSPIPVDDPPLLFNEILRSKVGLIGANQIGHVICRGQPDYETFFCCMCEHWATPSEMLSHLEDPDHQLKYVQKFFKEKYRKLIVSRSRDREALRKKLTMEISKAENDKKVVRKLNTILTVNILFKCWPSFLSHFNNLWKIEDDDVKEVKTVINLDSVPSRSSTTPAMLRRQSTTSFLSQNYDADDEEERKPNIADMNLCVYALVFIRAQAITKKGITITEIQKICQVIGVTPEMVFSDAVLEYAGQKIDSVEILVAISKYYANPLHSLSELLKKFVKTEPPLKPPKLLLELGLDNSKAAKMVRDVAMLNCIQPKNGGAVRRTYKFDEDTIYTDDFGRQQISYDGDYIEENNESIKETFHLPKRRKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA24</accession>
    <name>A0A914YA24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleosome assembly protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15610.t1">
        <property type="protein sequence ID" value="PSU_v2.g15610.t1"/>
        <property type="gene ID" value="PSU_v2.g15610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15610.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28300" checksum="3F6FB3FF63D779EB" modified="2023-02-22" version="1">MSSDAVKKEEVDAPSAKRPRIEAPNENNIGAGGDAPEEIAKLDAEAAAALFEKLEEVQKNLDVINEKASDEVLQVEQKYNKQRRPLFAKRGEISVQLPQFWMTALMNHSAFAEIVTEEEEECLRSLTKLEVEDAEDIKSGCKVSFYFSPNRFFENSVITKDFHTIDYEATCETTEIKWKIDRSKSPKSDKITFFAWLAGNTTDHMDILDVIREDVYPNPIHYFAATEGAAEEASSESSTEEDEELDADDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBR2</accession>
    <name>A0A914YBR2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBR2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17641.t1">
        <property type="protein sequence ID" value="PSU_v2.g17641.t1"/>
        <property type="gene ID" value="PSU_v2.g17641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17641.t1"/>
        </source>
    </evidence>
    <sequence length="395" mass="45355" checksum="80B623C716914A4B" modified="2023-02-22" version="1">MKETGESYRIFLKAPWEFPLKININSITIQQVDSIEKKSAQFNIHGELFFSWKDDRLEWNATEWKMESFLLHDTHHIWTPMFTDESSCTTLDGCISKVSDIEVFADGKIEARLIFRYPSYCAANYYNYPEETNDCCLFLSMIETERNVEYAIGARAKDKVNKQVAITDIQKEKDMTILTNVETSAWTVLDRTVDVVKLSRTRFLKICIHAKKDMNTLRVALRIPATIATLLMLAAPLFGDLRTQSFVKLTTLLLQTICFLFLCSIAPENGFGGQKPKIYSFYEFLFVNSAISIIITLVALALCRVKRTVPPSHNLFLTAKLINRFLCCVEPDPTMAYTRYLDDRENGALGEQQRSASDPSSDYTIEWRHLYIAANNLLSGINFTIFCFIIFFDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBT3</accession>
    <name>A0A914YBT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBT3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16219.t1">
        <property type="protein sequence ID" value="PSU_v2.g16219.t1"/>
        <property type="gene ID" value="PSU_v2.g16219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1870">
        <property type="entry name" value="ShTK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF108">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037710829" evidence="2">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16219.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13894" checksum="FED52B5AADFE267A" modified="2023-02-22" version="1">MMKGLMIFCFLFILISGQSTTTDAAAQDSTTVFVSTQSDAGNTVAATASTAVACVDTIADCSKYIAQCSDPNYQTIMYQKCRKTCNLCNACLDLDARCPQWARNGFCANPFYQQIWSECRKSCAICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC17</accession>
    <name>A0A914YC17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YC17"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16973.t1">
        <property type="protein sequence ID" value="PSU_v2.g16973.t1"/>
        <property type="gene ID" value="PSU_v2.g16973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF6">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16973.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14827" checksum="C5665105EA5EAD3A" modified="2023-02-22" version="1">MDSSPPTTTSDKINDVTMSWWTSAQAQTEVINLSRCTWEEAEKLGDKATKAPVLYTNTCFPHLIEEYPIWEDRLQVIYGLWRKLRLEQKVFYAEKARINRDLFKVPQQGDINSDLAEIEQMLDKMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCB8</accession>
    <name>A0A914YCB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCB8"/>
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        <property type="protein sequence ID" value="PSU_v2.g17870.t1"/>
        <property type="gene ID" value="PSU_v2.g17870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF529">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17870.t1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45922" checksum="5830E58052AB91A6" modified="2023-02-22" version="1">MSSKPGRFTIRVNTDSAINSLNSTSTTPTPLPLPPPPPPSSASSRRTSVFSNNSPAFNSTVPDNIDEYSITLPSRLSDYKPSLRNNSMPSMAHRPRHMSAGSIGSRRGTTSSNPSDSISENGSIYGNAKGFNSRMSTANSTSGGVVDSTHIQLYLPRRDSVTSPLGEVISIHRLPSNESSSQDEKEKLISSSTAFVEEDFPRVESPMNPRPVETWRRVGKQITPQTSTENNSTKQKSHYIGEIVFQLNDGIYFGGIESSLNHNLLCRLNIEFIIDVSGPESDNMLRTRTDKYQCLCGRKTPHSRTTLAIRIRDDSVDVMKPEFKGNQNAKTGTNSIGIEEEQDITDYFEEAITYIQRSIASGKSVLIYSLKCRNRAPSFAAAWFMHEQGLTRMQAIAKVSQIINDQLKASFIITTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCE5</accession>
    <name>A0A914YCE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16428.t1">
        <property type="protein sequence ID" value="PSU_v2.g16428.t1"/>
        <property type="gene ID" value="PSU_v2.g16428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16428.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="18174" checksum="E61EF53E5897FC76" modified="2023-02-22" version="1">MFNQQVLYETDLKALRGWNVFFYLWDHMSAPVQATLPQAKGAWHSSEIYYVFDQLIRPADVLGPEELKVQKYYADIFAQFAYTGNPRTPENHFPQYDLITRRSLWIDPTLSIKWNWITERRLFWAQHVTKFNFNILRGRTRWEIISGSPLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCF8</accession>
    <name>A0A914YCF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17104.t1">
        <property type="protein sequence ID" value="PSU_v2.g17104.t1"/>
        <property type="gene ID" value="PSU_v2.g17104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20813">
        <property type="entry name" value="C1_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17104.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15481" checksum="1C93005432CCCFE1" modified="2023-02-22" version="1">MMNASGNQKKQQHDFIEVSYHTSTSCDLCKRSMSSIFRNLVAYECKRCHQKYHKEHVEKNEVPPCKCTFESASELFIMAEREDQAKVWFNNLTKLINIRSTVKRANSTVNSRQGGVLTPTSLTSSSTPTRGFHFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDF6</accession>
    <name>A0A914YDF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDF6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17463.t1">
        <property type="protein sequence ID" value="PSU_v2.g17463.t1"/>
        <property type="gene ID" value="PSU_v2.g17463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036781051" evidence="1">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17463.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22649" checksum="D95DD9D503F6E1CF" modified="2023-02-22" version="1">MADLDTLVAQLAALTAALAQAQNVQQQQPITTQPQCVLPVFMLNTADPHYTKSWFAQVEMILRLHAHNDNDKVDLVMASLDTSTFSKVRRALLPEDITELHDFAKLKKTMIKLFDVEESLFAQRFAAFQIEWGGPEQESVREYEARIKANMESFEADQFGENEIATLNFVMGMKARALEPLRTIRNGCCFYPHAPRTTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YED9</accession>
    <name>A0A914YED9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YED9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17812.t1">
        <property type="protein sequence ID" value="PSU_v2.g17812.t1"/>
        <property type="gene ID" value="PSU_v2.g17812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17812.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23412" checksum="D279872E9583D145" modified="2023-02-22" version="1">MSRSTPLMSPLREKNNERSSLKFWQSKYNKSFYVVLCIHRSKIPFLEFYEENHGHSAFIDHQPVKVVDLIGVEDIKICPKNDHRFIISFEEADRKAIKLLAANYELACYWIDEMKISLTMINALKGPTYQIPEHENYFGALQSQESLDEHSPESSSSHRQQTNSNGQQLVLPRRAKIPKSMEEVLEEVKIRQQQANVFKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFF0</accession>
    <name>A0A914YFF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFF0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19025.t1">
        <property type="protein sequence ID" value="PSU_v2.g19025.t1"/>
        <property type="gene ID" value="PSU_v2.g19025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19025.t1"/>
        </source>
    </evidence>
    <sequence length="838" mass="97506" checksum="50E3E663B6E330A1" modified="2023-02-22" version="1">MDGYACGVRCTRIAESICFEGENTLINPFYDIAERARVREIVHILAFDGCPDDWFPGVKTATDYLDSTEHLKIREKNNKLDTKENSTVISENVKANENPFNVSVGCLNEPMQNMDIDESMDIDENDIFLTKFEEANLHQQIRENFVDYCKRKGVKRNNEARIEFYAEKGTAKEKLSQNESFKTLNSATVISEKVQTETNIEEEHKLLSAEEETTLNNEIRETVATFCKRKKIKNDAKGKSKYHESIKIAKEKLANNERAKECIKNRHKTEATVIDRALGVVDEFSQDSQRMSIEEEKRLQIEARESFVEYCKRLKISKAKSRNKYNAAIKTVKEKLAENERLKAHMRKKRSAESAEEKQERLKNIAASMQKIRDNETEKETFQRLQKDTKLKQIKRENETEQEKEERLKKDVELKQKHRENETEYEKSQRLKKVSESMQKIRDNETEDKKQDRLKKVSEAMQKIRDNETEEEKQERLKKIAESMQKIRNNETEEEKRQRLNTIQNQIAIKRTVERLEKQEKLKKDREDRIKNAQAKSSFIPKKGANYKSVQPFRLGKRDVICNGCGAKHYRTEKRQTDGTFTNCCQKGKVKMQVGIKDYPQLFKDLMTKKHENKTFAKLFDLEKRTINSSLSCAHMYAKNVKMAPGVPCLKIQGKVMHKMPKTYLPSGENATFGGQNYVVDSGTATASRIGAAAKMNKRFSIDLMAELDQTMRKVNMFAKSYIMLKDTVEKEKANQEAKGEQPRELRLLFKGNPNAPRNYDKVEAENEIALVFTPGPDGEVPRDDIVIYDKKSGNNVSEYLRSWDPRVEPLTYPLFYPTGNETVYENQKRSRCRKIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGH1</accession>
    <name>A0A914YGH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGH1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18548.t1">
        <property type="protein sequence ID" value="PSU_v2.g18548.t1"/>
        <property type="gene ID" value="PSU_v2.g18548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18548.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10244" checksum="7903118C8482942A" modified="2023-02-22" version="1">MELLKFFDKYDFQSLKDDLEAELISEIDESNVCLLTNCSLLSNASKLEEESAEFLQHCLKTSNPVADFDLLDKNFAMNLLKNSFYHVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGV5</accession>
    <name>A0A914YGV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGV5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18024.t1">
        <property type="protein sequence ID" value="PSU_v2.g18024.t1"/>
        <property type="gene ID" value="PSU_v2.g18024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18024.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17210" checksum="FD146CD65757910A" modified="2023-02-22" version="1">MIKATIGDSVSTTAASSSLKLGEGINETPDDVDVKELIALAHHKNYHHKETATPKFNTVTPQPSADSESLKVAHPDTFQPHDTAHFGNLRYLDFAPESKDKQFSTTETPSEEETSESLLLPETANNNNNNQQQQQQQLPPNPYFLALANNPIKSSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHB7</accession>
    <name>A0A914YHB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18717.t1">
        <property type="protein sequence ID" value="PSU_v2.g18717.t1"/>
        <property type="gene ID" value="PSU_v2.g18717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18717.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18210" checksum="37F9659E81E8EA1B" modified="2023-02-22" version="1">MEILNKGSSASDTAAINGGNPSSDLMETLNAVNAVKVKSWGTIQTVKNYIAKKVEAEEKEANKKDESKKNIFYSTLIFLFLLHLTFQTGEITEKRAETLDPRISAYKEGSVNSATMNRTEENNVNDPPEINAANTAKVASWEAVNAAKEYGAEQAEKAKEHKADNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI19</accession>
    <name>A0A914YI19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1897.t1">
        <property type="protein sequence ID" value="PSU_v2.g1897.t1"/>
        <property type="gene ID" value="PSU_v2.g1897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1897.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11283" checksum="DA433D8AE8B9D8AB" modified="2023-02-22" version="1">MASSGGDINGGGGGSSTSGGNGNTNNENSTTNASGSSRTTTTSRSTTERVIKSVQFPISERLGVDDVYDRRAGKPKSDVLKDHFIKEGRIEEEAALRIINGKIAYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI62</accession>
    <name>A0A914YI62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI62"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17007.t1">
        <property type="protein sequence ID" value="PSU_v2.g17007.t1"/>
        <property type="gene ID" value="PSU_v2.g17007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17007.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13909" checksum="AB8EDF89002F1403" modified="2023-02-22" version="1">MKKVNQVPVLSEQYNGIIVDQLDRVTVEIAPRKPQGKLVHYLTHHAVLTPQKATTKVRMVFDGSAKAHKDAPSLNDCLLRGPSNLPDLSGLLLRLRTCKILITGDIEKAFHQVLLNEPDRDAVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI89</accession>
    <name>A0A914YI89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YI89"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19206.t1">
        <property type="protein sequence ID" value="PSU_v2.g19206.t1"/>
        <property type="gene ID" value="PSU_v2.g19206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF442">
        <property type="entry name" value="PROTOCADHERIN-15 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="914"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="379"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="585"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="687"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19206.t1"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112452" checksum="73FF843CFF1F76AD" modified="2023-02-22" version="1">MIRIVEGGAGNFGIDEGTGELIYNGPLERIAKNYTLKILATPNPHSPTVALTTAQILVAGIGSHLPTFTEPFETLILNYTTKTETKIHQLEAIDSDKNAALVFAIESSSNLDFLSNSIPFNGEFAVYPNGEIIVKNLPSTLMSTTLNVSVQDKSHKLETKDYAQIVITIQHQKSKIDITELFSFEALETPLIIADDLPIGTYIYTAILKPLSFDNDQLLKPKIIYSLINNSKYYKMDEQTGMIYTLSLLKHIGLQNLTVLAEISTIKGNHKLTTVIPIDAVSMDIEAPKLKNDENELKLSVEENSPIQTQIGQINLLENENDEGETFFEIIGSVNDLLEVDNRGRIVVKQNIDYESVKEILFFVAIKVINVNDEMPIFESAETAFSTFENAPIQTFLGSMMATDKDGDRISYSLNFPKDSPLLGKISINSQGHLTTSAPLRKLEGTFKFMVFAKDGENTVSQECDLTIIATSRCQPIFDENQEIIFQVNETLNPGNSFGAIKATIEDANDCDPLSYQLQFLNNSDSTKMFKLDPISGILSSYSSLQNNVGLRFPIVISASSGNFYTRKSAEIRIISTKSEPPNFPQKHVRIEIAENNAVNISLGSFKALPSNLGDQIYYKLEDNFDKTFSIDSEDGTINVLKSLDREVKSLYRLKVVASTNKNDSLIDTAVINVVVTDLNDNGPTFERDFYEIVLDSKTLPGKEIFSLQAKDRDMTTSKAAATISYKIEKVIFKHRESSASIFNGIFEIKQDSGKMRILKNLTDFSGGLFEVSISATEQEDEISHLAHTTLNIWIADREIHSIPILIHQNPIQLSNDQLRQYSSKLAQAINDSTVLLLSLRFHYLNSEASTPLIVRDSTVAEFIAVNRKSSSIHSWNSIKSFIRDLDIDGMSLFTGATIQNSNSQSLMSAEASLTLLAVIFFLLLTMAMTILGCILCYYRKKFRIEKNNLVEAKIAAATLHRRTAAPVRHWSPYLERPPELLWERSTTATMGSTTPETYSVQEMKIAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJU8</accession>
    <name>A0A914YJU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJU8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20615.t1">
        <property type="protein sequence ID" value="PSU_v2.g20615.t1"/>
        <property type="gene ID" value="PSU_v2.g20615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20615.t1"/>
        </source>
    </evidence>
    <sequence length="1030" mass="115703" checksum="4078774C19BFD2D6" modified="2023-02-22" version="1">MKVDFFVVQEFHDLIDQSQGTAAEKQYINVHQKQINLDLLRTMPNNLHFMSATCKGVTQLQSILRAYCLHNPTLGYCQGMNFIAATALLFVSPEDGFWFLVAITEKLFDASYFDQSLTGAQADQEVLKEILERRYPRLAQHLEEHDIDLTTITLNWFLAIFFDAVPFQTMLRIWDIFLLEGSKILFRISIALLGLCEEDILARSDTISVIKVLKAAVKLTYDADGVSFFLIQHAFDELHSFPSKSQLATKQKMYLTVLQDRLFKRQQIRDLLGDYSDSKKSNSDKLCDLPVDCIVFSSGFGEDGLGYVTMGNQKRGKVALITMYKQGAANLNIIDLEFDCKPVSMVIYESEMAFISLLSGYIVAIHLNNGKGQILWELKLNDVALKLIHSENKLYAALANGTLTVLEDAFNKAPSVLDFYHIPISAAPITDAFIDDENLYLAVACKIVILNKNTLSPVGNIYVAASAAGSTVPMFEKIRALSDSEYGIWVITAHSSLIQLWKDSQCQLLFDVTYDHSHRKPSFDEHDDLETVEINTILYFENEIWVGTTDGYLMLYQVQPNTETKSINNNRWEAYAPTKISNKVRPNSSNEVSFSLHKYPAGKRLSPINNAAHLLPIHRQNMYYIPTLKETQVEEHTSERECSPKDRETRKISVIIDQNTKKYSVSVAPVHSISVSRSISIDSANETMKSPSISSKFSFSKPSSLALQRSKTFNRFSGRIKTPVEKTNSIDSAVSSVFDGDFNGTAAAKKSPTKSCGSDDCFVSNVPTIDESVETPLSEQQPETIVKESPVFSTGESMEYDDMFEVYSETDIALQNNGLIEEDIFQRSPPSSSKLVQIPVRKMSFNAFGPCEISVSRQASTSLTNSSFPYEFDERGDEGGESSPTEIACPSQTSQETSVDQKDLPKLRRKDLNFDDFPVIVAVKDNVSEHRIAEEILDDLNSTVEESEIKCSLTMNLQMKIKISDKPVRCVTLIKCENENIVITGAGNYGDEEAILRWRKEKTTGLWINDPLVDINVHGRRRTIFGKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJW0</accession>
    <name>A0A914YJW0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oligopeptide transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJW0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1961.t1">
        <property type="protein sequence ID" value="PSU_v2.g1961.t1"/>
        <property type="gene ID" value="PSU_v2.g1961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17347">
        <property type="entry name" value="MFS_SLC15A1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000537">
        <property type="entry name" value="Peptide transporter family 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000049">
        <property type="entry name" value="Solute carrier family 15 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004768">
        <property type="entry name" value="Oligopep_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00926">
        <property type="entry name" value="2A1704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="804"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1961.t1"/>
        </source>
    </evidence>
    <sequence length="829" mass="92148" checksum="45F59D09A65BDB5D" modified="2023-02-22" version="1">MRRVTITEGSLKDEMPVERRRKEREPQPETWGEIFRAWPKTTLCIVSNEFCERFSYYGMRTVLTLYLLNVLKFSDNVSTVFFNGFTVLCYLTPLLGSIIADGYIGKFKTIFTVSILYAAGQIVLAFSSINNSSSPLHPALDLAGLGIIAFGTGGIKPCVASFGGDQFEPHQTRMLSLFFSVFYFSINAGSMISTFISPLFRSMSCLGQDSCYPLAFGIPAILMIVATIIFMLGSFTYKKPPPKENIFGEVARLMTRAICSGGNGPKRDHWLEKYLNNHRCETDPKCMELKSRKRDNSLCQKAEFIEDVKSLLRVVVMYLPVPMFWALYDQQGSVWLIQGIQMDCRLWGSTLLLPDQMQTLNAVLILAFIPLFQVIIYPIASKVVTLTPLRKMVAGGVVAALAFVVSGFIQLAVNKTLPDLPPSGNGYVSIMNAIRPGCNINSTMVQGTLYKDNGFPLAYNSSLTDDKNNNVAQMIKVGADKNIIFTFAYDCGNTPGLVMNYTAPVVDDGSIYNLIVSELGIVMLEVDPTKPTEGTGEFSLSLTMALNDTNYVGHMALCRVGQDNPCDPTKPADFYYYEVNYDDEKDTDLDTIIPYTKNDGTFNTQQFVSGYAFKAIRPGNWSLVYLHNLAKSIGMQSLKPSEVNFTETGIYIAINNQGGVYAALLTGGYDKPNYLVNQIVPFNTVSILWQIPQFVIITIAEILFSITGYEFAYSQAAPSMKALVQALWLLTTAVGDSIIVLIAVLDIFSDQAVQAFVYAGAMFVVIVIFALMSIFYYDYKYYTGEGEDDDDDFEDEDAVSLAQTKDALPYENGHGRMNKGFDDSWDERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKP4</accession>
    <name>A0A914YKP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20915.t1">
        <property type="protein sequence ID" value="PSU_v2.g20915.t1"/>
        <property type="gene ID" value="PSU_v2.g20915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20915.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30607" checksum="2AA033F37C999C57" modified="2023-02-22" version="1">MPFGSSSSKPSFAVPGQQPFKPVIIHKSSNLPFFEDDTLAKLINSAEIGVNYDSDGSESTAPETSNRNFTPLEYKIDHYLNVPNFIVVNKMKKEIAQSMPKPKLNHLLNFWLENFSGFPELVIFFQYLQYHIEIFKLVDCLTLKTYHSLIDAVVQREPMFQLINHLVANIPLMCQYKFLIYDDNYPDFIFVNSELLDIQIYPLASGLPTSVMYLFYKKRRWIISDLKKEFRDCSDAEFYRQLNNFLNDRPDLVMLESSKPKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM92</accession>
    <name>A0A914YM92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YM92"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20694.t1">
        <property type="protein sequence ID" value="PSU_v2.g20694.t1"/>
        <property type="gene ID" value="PSU_v2.g20694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20694.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37578" checksum="E769E293EC458358" modified="2023-02-22" version="1">MSKIRENILKKTLSIGSTKEKEADEKSIISVEALDEPQTNWRSIYVAAALSFIGSAQYSLYFSALWPYLQTLDRTATEQFFGYIVAIYSVGQIISSPIFGYWSNKCKEVRLPLYVGLFFMLVGNILYIALEFVPFSRKWLMLIGRFINGAGSGNVTLLRTYASTGSTVKDRPKAIAYATGGQALGSTCGPLFQLVFTPIGYPGFKLFGIITINLYTAPAYLACLMNIVGAIALKFLFKESYAGIEEAGPKTETDDSSLEIKSPPKLPMYDIIAVLVCYGTRFTQMFINANLETIGSAFSMMMFDFSETKSVIFTAAAQGAIGVFTFITYLAYIVFNLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMA5</accession>
    <name>A0A914YMA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMA5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20516.t1">
        <property type="protein sequence ID" value="PSU_v2.g20516.t1"/>
        <property type="gene ID" value="PSU_v2.g20516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20516.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32571" checksum="C6FB72FB2DA37EFF" modified="2023-02-22" version="1">MEKMTSNITDIDPGQKLHFFITSLFSNNFFYNYEFFETSPSNIQLIDNVKVVKWWNPDILFRYGESVTRFELFKRRMKIGYSKFGESLVSAITILPTNFNDLERNVDIDAIYGDKIVVLTQKFAKLYYIVSKVIEAEKYDFFGQNSVITFTFIYKKSISMELHKVENGEISLLERMEKRFLVLKESETELLSNIESIQNHLNSGYEKSDLNVIFFDYNIGNMDQSKYNEYFIIERKNLTEDDLMHAGAVFKAKSDFIGNIISFVDITKILKKKVSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMB3</accession>
    <name>A0A914YMB3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21479.t1">
        <property type="protein sequence ID" value="PSU_v2.g21479.t1"/>
        <property type="gene ID" value="PSU_v2.g21479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="7">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21479.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12102" checksum="E321F487845D91E6" modified="2023-02-22" version="1">MHGILRKLQLRRLFFVENVVDSVKFFFLLYSLTYIGAWFSGFALVILFVIGVFTIPKVYEMNKEPIDNYLNLAKENVDKIHQTVGEKVPFLNTSTTVAPATKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP83</accession>
    <name>A0A914YP83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21232.t1">
        <property type="protein sequence ID" value="PSU_v2.g21232.t1"/>
        <property type="gene ID" value="PSU_v2.g21232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21232.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19895" checksum="C323EF3CF1C70D64" modified="2023-02-22" version="1">MGNTYSSSPPEPAPMMDNPGYPMPDFNNIFHKGVPKMMQVTDDLHRMTDYIMDLRNMMIGLALLSIVGVLMFLILKWNNGRRTNRGRKRLNEYSSEHSSLSRPYRTYPQKSVDWTLHHHNMNMEKLLDHSGNNSPPHNKIEFQHEPGTNANIPNGNMGNMQKVSDLIDLEKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQG2</accession>
    <name>A0A914YQG2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914YQG2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2419.t1">
        <property type="protein sequence ID" value="PSU_v2.g2419.t1"/>
        <property type="gene ID" value="PSU_v2.g2419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000042">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="135"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="14">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="333"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2419.t1"/>
        </source>
    </evidence>
    <sequence length="500" mass="57223" checksum="D77390E35D5CBD26" modified="2023-02-22" version="1">MFVTDIFVDALIKASTKTSIAVLLCLFVGQITSLTILPIPHQLAKQYKTNYDEFANHFLLPQDFDLAEKTPVKKPTPSEIDAMQNSNLFEGDIIGVPIDEDPSAYLYKKLRDQPLNEEDTNFDEIFNRPYHSSLNLVTYPDKLWTKGRVPYMLEEGMTPSQRAAIAQAFDEYKEKTCIRFVPRQDEDYDYIYIKRNVAFGCSSYVGRAGGNQTVSLEVGKCFTKGIIAHELMHALGFFHEHSRTDRDDFVKIDEENIRMLRNFEKYPRKIIDPLEMPYDYESVMHYHKLAFSKNGKPTIVPRDKDAEIGQRYKLSTVDSQKVNKLYQCENITPDEITTHPSPTTRRPKVTTPVTRRTTSDRWASKPSSKPTTTNEPKTTVSTTTSTTTTKLTTLTSKSFPSTTTRKPFTKAPEKCENLNAHCDMWEQLGHCEHSAKYMQHYCRKSCGLCTEDSKETIAPPPEEKSCTDKNLFCGYWGKIGECKKSKFMKIFCKKSCGQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQS3</accession>
    <name>A0A914YQS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Voltage-dependent L-type calcium channel subunit beta-1-4 N-terminal A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g237.t1">
        <property type="protein sequence ID" value="PSU_v2.g237.t1"/>
        <property type="gene ID" value="PSU_v2.g237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11863">
        <property type="entry name" value="SH3_CACNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046937">
        <property type="entry name" value="CAB1-4_N_A-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12052">
        <property type="entry name" value="VGCC_beta4Aa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Voltage-dependent L-type calcium channel subunit beta-1-4 N-terminal A" evidence="2">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g237.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14941" checksum="6040B4A1DC2F24AE" modified="2023-02-22" version="1">MSKFRRRGSGDSNFSHHDNEYDLEQRNRETIRSNAERQATQQLENAKYNPVLFAVCTNVDYDGSIDDDSPVHGCAVSFKAKEFLHIKEKYNNDWWIGRLVKEGQELGFIPSPVKLENIRQQSTKGNHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSK5</accession>
    <name>A0A914YSK5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock 70 kDa protein 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Stress-70 protein chaperone microsome-associated 60 kDa protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Has peptide-independent ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds UBQLN2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Microsome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSK5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20393.t1">
        <property type="protein sequence ID" value="PSU_v2.g20393.t1"/>
        <property type="gene ID" value="PSU_v2.g20393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10237">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000030">
        <property type="entry name" value="Heat shock protein HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042048">
        <property type="entry name" value="HSPA13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20393.t1"/>
        </source>
    </evidence>
    <sequence length="440" mass="48388" checksum="176C4ABCF78552BD" modified="2023-02-22" version="1">MSTSVSLIGGGILVLLIAGYLAQRNGLVPPPTPKIAGIDLGTTFSSIGVYQAVTGDTEILPDILGKRSVPSVVGFLKNGTVLIGTRAVEQQEHNPKNTIYDAKRFIGKTFKSDDPQFIADLKRYPFTVKLDSKGKAYFEVELDTGIRKVSPEEIGSLIIKYLREIANDKYQTTIPQLVISVPAEFDENQRNYTQKAAELAGLEVRRIVSEPTAAALAYGLHKKKGVEYIIVFDLGGGTLDVSILWLQGGVFVTQAMAGNNRLGGQDFNERTQKHLIQIIEKKFDKKIVDKEDIQQIRLAIEEAKLRLTDVPSTNIRLHLRTVGEFNYELTRKEFEELNKDLFDSIVDPLEAALADCNLKPEDIDEIVLVGGSTRIPKVRQVVGSYFGKAPNYGVDPELAVVTGAAVQAGVIGGGWPLQVTAMELPTNRRKVHLYTHNSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSY3</accession>
    <name>A0A914YSY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA-modifying protein YgfZ</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSY3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2773.t1">
        <property type="protein sequence ID" value="PSU_v2.g2773.t1"/>
        <property type="gene ID" value="PSU_v2.g2773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.160:FF:000001">
        <property type="entry name" value="tRNA-modifying protein YgfZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000002">
        <property type="entry name" value="tRNA-modifying protein YgfZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1630:FF:000001">
        <property type="entry name" value="tRNA-modifying protein YgfZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01175">
        <property type="entry name" value="tRNA_modifying_YgfZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023758">
        <property type="entry name" value="tRNA-modifying_YgfZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048451">
        <property type="entry name" value="YgfZ_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007110">
        <property type="entry name" value="PRK09559.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21130">
        <property type="entry name" value="YgfZ_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-modifying protein YgfZ-like beta-barrel" evidence="4">
        <location>
            <begin position="244"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2773.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36108" checksum="3D9115D907D9EFBE" modified="2023-02-22" version="1">MAFTPFPPRQPTASARLPLTLMTLDDWALATITAADSEKYMQGQVTADVSQMAEDQHLLAAHCDAKGKMWSNLRLFRDGDGFAWIERRSVREPQLTELKKYAVFSKVTIAPDDERVLLGVAGFQARAALANLFSELPSKEKQVVKEGATTLLWFEHPAERFLIVTDEATANMLTDKLRGEAELNNSQQWLALNIEAGFPVIDAANSGQFIPQATNLQALGGISFKKGCYTGQEMVARAKFRGANKRALWLLAGSASRLPEAGEDLELKMGENWRRTGTVLAAVKLEDGQVVVQVVMNNDMEPDSIFRVRDDANTLHIEPLPYSLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTX2</accession>
    <name>A0A914YTX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTX2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20900.t1">
        <property type="protein sequence ID" value="PSU_v2.g20900.t1"/>
        <property type="gene ID" value="PSU_v2.g20900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20900.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="7815" checksum="2E2A2FAB5CEE3A83" modified="2023-02-22" version="1">MVSDWHRDAGFGVHPAGADDLHLRTGVQQRADAGFTESGRSGHAARHLADGDDRADCRTGKPGVRHSAGLAGDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU71</accession>
    <name>A0A914YU71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU71"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3205.t1">
        <property type="protein sequence ID" value="PSU_v2.g3205.t1"/>
        <property type="gene ID" value="PSU_v2.g3205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3205.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12314" checksum="8A136F3E64BAEAD8" modified="2023-02-22" version="1">MNDEDGCQAATPATEGRRYALRRRRSYPKDDDDGSCKSTMAATADEALFEPSTKTLKPDSPGEARNLALIDGTATTDPSQSIASSSKIISPTNLHIEISYFDLLSEEIILEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU81</accession>
    <name>A0A914YU81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU81"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4204.t1">
        <property type="protein sequence ID" value="PSU_v2.g4204.t1"/>
        <property type="gene ID" value="PSU_v2.g4204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4204.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38690" checksum="F4D4A281B57AE4DF" modified="2023-02-22" version="1">MTDESSIEFAKPDYINGRFGNPKSFTDWKGLPSPLDVFKWKALEHNLSLIPTEEVLEKNLPVISPEYDLKSELSATWLGHATVFVHLEGINFITDPVFATRASPSRFFGPRRYRKPPSKFNELPEINIGVISHNHYDHLDAEAVKQISLLNSKMTWFVPLGLKTFMDSIVGGAKVIEKNWGETETIEFNGKQFTILCTPAQHWSQRGVFDRFKTLWSGWALLGSQHKFFYTGDTGFCDEEYKKLGKKYGPFQLAAIPIGCYCPRWFMQSQHINPEEAVAIHKHVKAEYTMGIHFGTYEMGSNEPYLEPRELFLKAGENLPEGEIFTLGHGVTWKYQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUK2</accession>
    <name>A0A914YUK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3664.t1">
        <property type="protein sequence ID" value="PSU_v2.g3664.t1"/>
        <property type="gene ID" value="PSU_v2.g3664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3664.t1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45282" checksum="5087A2AB4E933598" modified="2023-02-22" version="1">MELIVSGSFKCQVFLELYMKLEDIKLIDKGRLELNETFVGQNASFWWKSKNDAMLPSGIFFDSFNNVQINILNSSKTVPYFLRIGSFQPLPSMKFKFDESCNGAEFELFINLQNTPDCQIRIHQVKEGFKFSTKSSSSDEFIKDPSLSPTLIMGKNGIYVKIASLLTIKSYPICNVSTPDVPADQFVIQISRIHKIACKKAEVTILKEDVANGIEILIDRSKIPLPTPAGILNSTVVSATAFLSAKAALEWWWFVAGGILLFLILCVALPILIICIYRRKKKQPTKKRFGKFPKVLSVMKFPFNQKNLKIKQKQRIVQLRKNPSQKVFKWKIKNQNKLKRKMPRIKKKMEQKKILQRIKNLSNNLLLQENEQKFVIHFEKDVDTKKNLLLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUS3</accession>
    <name>A0A914YUS3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3731.t1">
        <property type="protein sequence ID" value="PSU_v2.g3731.t1"/>
        <property type="gene ID" value="PSU_v2.g3731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000006">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF351">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="18">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="152"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="19">
        <location>
            <begin position="290"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="492"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3731.t1"/>
        </source>
    </evidence>
    <sequence length="679" mass="76667" checksum="5B00D2C84D55BBB5" modified="2023-02-22" version="1">MPHQNLNTYICAGDHPDITEERKKATFNTDNFAATLWGTHEKLERRREIAKYVEEHPELHDPYPTEFMDRQESLENVTRKTLLWMEHAENAIDISKQEEGFYFGTLITGSQGHPLSIHLIMAIPALMNNADEEQLDEWLPKAINREFVATYSQTELGHGTNLSKLETTATYDPKTEEWILDTPTVTATKWWPGNLGKSANYTVVMAQLITHGKNYGAHPFFVQVRDEKTHQPLPGVILGDIGPKFGMNANDNGFMQFKKFRIPRRTMLMKNAQVLPDGTYKPPLHPKLGYSSMIFVRSAVVGLMSLYLGQAATIAIRYSVIRRQGEIMPNAGEVKILDYQTQQYRLIPQIARAAAFRFAGIFALEMYNTVIHEISKGNMDALADLHALASGLKAVATFQTALGIEQCRFACGGHGYSLASGLPQIYSVAVGGCTYEGENMVLLLQLARYLRKRAIEIKSGGPKEKPTELSEYLFKTSAKHSLIGTNVSSTNFEHVIESFEHVARRLTLFAHSKLEKLEQSGMEHEIAINQTAVPWRRASHAHTRVALTRIFAHAVQRTTDIAVKEVLQDLIKLYIYYEVGECAAELLEDGFADGHQIEFAKDQVLEVLEKLRPNAVSIVDSFDFNDRELNSVLGRRDGNVYENLLAWAKSSPLNKHDVMPFHHKYLGKMMEDAREQSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV90</accession>
    <name>A0A914YV90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g406.t1">
        <property type="protein sequence ID" value="PSU_v2.g406.t1"/>
        <property type="gene ID" value="PSU_v2.g406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45830">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45830:SF15">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10318">
        <property type="entry name" value="7TM_GPCR_Srh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g406.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31339" checksum="70DA19B4332746AB" modified="2023-02-22" version="1">MSLLYTPKILFPALAICPQGILKTTNVAITHVCFWIFATLFGCSSMAVCGAFIYRFAALTDRLKKFLSKKYIALFAFIHIAYQLPTIILHDFAHVDRSIIDNAILTQWPNIRKYYDDGCSSIHFYTTPFATLFMICLTLSFLLTVPLIVVLLVKSFTSLNHQKQYMSQKTYKIHRQLLISIVFQTAVPILTLFAPYSFAFCLLLTGMENVSFIMQGAFIVGTIHSPLNTIMMIYFIQPYHRFFTNIYNRIHPKRSIFPSYTDAQHSEAPNAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW87</accession>
    <name>A0A914YW87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YW87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4380.t1">
        <property type="protein sequence ID" value="PSU_v2.g4380.t1"/>
        <property type="gene ID" value="PSU_v2.g4380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4380.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23660" checksum="6D05644750BAFB99" modified="2023-02-22" version="1">MNITAPTFDDDTIIDFVKTASRVAFASAAAIGIPGNLFVLFAIIYSRDLRTVSNIFIFNLALADLLFLMGVPILIIQSIKGEWIFGPIVCKLYLASSGVNQFASATFMAVLSFDRYLAVCHAVLPLIGVWYFYSKIIILVWLRRSRFWAQRHRLRRTTTKVTVMGLAIVFSYTVFYLPFWIVQWSIETEASWMMKKPYFYTKSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWD9</accession>
    <name>A0A914YWD9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YWD9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3976.t1">
        <property type="protein sequence ID" value="PSU_v2.g3976.t1"/>
        <property type="gene ID" value="PSU_v2.g3976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3976.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15889" checksum="158A0F3F3765505C" modified="2023-02-22" version="1">MIFLDLIHALKWIKKEITTFGGDSERVTVMGHSGGGGMTKTLAMSPKAKYMINQMIAMSQSSDYSLVKDKNEAASRAAAQEVGCANFDPSDKKWDSLKVVEKVIKCLRTKSGKELTEAQPKIEEKGYQFRYAAQDSGENAVSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWG3</accession>
    <name>A0A914YWG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4309.t1">
        <property type="protein sequence ID" value="PSU_v2.g4309.t1"/>
        <property type="gene ID" value="PSU_v2.g4309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4309.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="30052" checksum="6037F8839ACB28D6" modified="2023-02-22" version="1">MSFGPWQETKSSSGKIYYYNRLTEKSQWVKPIEWIEHDRLSSGDRPKLKPITPPPMPPPISSHPKREREHYHRHHEVHSPQPPPHSTISNQHTYSHFIYPSKSNTTNINDGNEETLSDDKKLEAISDDDDGSSGPPIKKIKCEDPLANIEMISEDSLSASKETTDERENYLPMHDDELDRYITDEFLSKIRIPEIEHIDAESRKMLAKQREAEKELFEVIKDQISVRQLMTTTQIMRKAVEIRSEFAKSQCESHGFDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWQ6</accession>
    <name>A0A914YWQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2515.t1">
        <property type="protein sequence ID" value="PSU_v2.g2515.t1"/>
        <property type="gene ID" value="PSU_v2.g2515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011:SF6">
        <property type="entry name" value="HIGH ZINC ACTIVATED NUCLEAR RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2515.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17121" checksum="3B6ED7C39F253EA5" modified="2023-02-22" version="1">MDFIVKFVNSCRACSAFYKRAIQSKKRYRCQKGDGKCDLTKKSKGKPICRYCRFKRCSTIGMKFDSGAQESLPSIPTPPSLHLMSDKCIKVDYQFDGKTFVVNWNSLSESIQEFLNTETNYIPNFGSTHLTDMQKFQIGIERLLTEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXL3</accession>
    <name>A0A914YXL3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YXL3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2826.t1">
        <property type="protein sequence ID" value="PSU_v2.g2826.t1"/>
        <property type="gene ID" value="PSU_v2.g2826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="415"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2826.t1"/>
        </source>
    </evidence>
    <sequence length="790" mass="91830" checksum="C332562FB80A6FEE" modified="2023-02-22" version="1">MVAMSKYLLSKKRHDDFGASRFVFRLAFDDMGAFDDPKAEFLEAIQSIINQILTEDSSIKKIGLVLSSSLLPKGDLLIPFTEIRSDFINIISNEIYKLQQSDGFTLLLDLPFNVTVTTHSPSRGRGKINNVRSFVKKTFLFDLDLNDGLCLFYSLCAAMAFYETKPNTVERRNVIVKYNGPVKSEILLPIYYSKKHYAAIKNLSMFTSGKTRYQWCEECETTFDRIVRHANKCVLKCGKCMTFGDGSCASDGSFITCNICNRYFESKICMDRHIKNNICNIVVTCDLCGATYSKRHTPDHTCNTRFCYTCKSYHETRECFVSVLPEREIVDYRIIIYDFETSCEEYIDEKTMEHTVVFIAAYVYCTRCIFNQTWQNEVFKCDICGPKRWYKWSAINGDDCMLNFIETILYEFNNKYKSTLLAHVSSRFDGIFVLRKLFELNISPKVIKKGNKFYLIRVPKRKDSCELAFKDTYLFMGASLDKLVTSFDLDVESKMFYPYEFIKRENFNVELQTLPPKHMYNYKYMKEDKQILFDEWYSRNYNTKFSLKDSLDEYCTSDVKILSHAVVAFLDLFYKITKTDPFQSQTISGACMKAYRTNFLPEQSISIMPENGYGSHDKASVMAIKYLMWVSKKDNIFIQHRNTLEGEKHVCGFKLDGFAPATNTAYEILGDVFHGCRICIKERDKIMPTGRTAEMDYQKTMERIEIIKDAGFNVILKWEHEIRNELKTNNDFKHFYDTEIIAGPISPRLALFGGRVSPQQLYTKAMDGYCIKYYDVRSLYPSIILCMSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXY2</accession>
    <name>A0A914YXY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXY2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4499.t1">
        <property type="protein sequence ID" value="PSU_v2.g4499.t1"/>
        <property type="gene ID" value="PSU_v2.g4499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="135"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4499.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="49093" checksum="E43F2B3D8AF89AB1" modified="2023-02-22" version="1">MDIIQNLRRQRELQKARKQKQLLSIHHQPSPIQEQENKVSPIKQLPPPIPEPQKVSPIKQLPSPIIEEPQKVSPIKQQPPPVKEDPSKQRPQQSASTKQQQPSSTPPKRPLPAKLQQFRLKHTEQKQYVVHGKTYTIGCELGRGGSSRVYEAKYNDILYAIKVVDLDNVDQRVFDGYMAEVQLLQDLQGKDGIIQLEDYELKDDDYGKELLVVMEKGENDFQTFLRSSDRSPHMIRYYWESMLNCVKVVHSKTIPTDLTSIVKDCQAGTLNYMSPESIEHRGDDNKFHVPLASDVWSLGCILYLMVYGTPPFGHITSQMGKMNAISTKDIEYKPIDDEHLLNCMQLCLQRDYQSRPTVSQLLEHPYLKPNLSNTSTTLNSAIPNFLSSSLNESYEEGSIIVEKIFEEVRNNTPRTASKNVYKLLKANKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ84</accession>
    <name>A0A914YZ84_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZ84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5261.t1">
        <property type="protein sequence ID" value="PSU_v2.g5261.t1"/>
        <property type="gene ID" value="PSU_v2.g5261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="8">
        <location>
            <begin position="57"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5261.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31821" checksum="2E83CC0D8F30F819" modified="2023-02-22" version="1">MQLKKRLLQQLYQIYVHRCPPKSFTANILTKKWSAETKPLVKTVIEKLNVKPDDNILEIGYGRGNGFPYLFEKFKDGKGWVFGLECSPYMEEIVRKKYAVEIQHDGILFLDHIENIANLPYPNNTFNGIYHVDVFYFWQLDGMRQIVQEFLRILKPGGSLLCGLEMERLKKLERRNVLEADEYNPMRYTQYLEPAGFKDISITYEKPLPSSSREFILIKATKPSLTEDDLDPEKKMEKLEVMIKEKLALDSLVKSKNAMSRAMKEKLEDAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZW6</accession>
    <name>A0A914YZW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZW6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5470.t1">
        <property type="protein sequence ID" value="PSU_v2.g5470.t1"/>
        <property type="gene ID" value="PSU_v2.g5470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5470.t1"/>
        </source>
    </evidence>
    <sequence length="425" mass="49352" checksum="4C3646A7117AC768" modified="2023-02-22" version="1">MQNCDVPDVFLISHVSPIPKISNPIQLSDFRPICGTSEVLKTLERYPKDQLLLHLHVNKLLPKEQFGFLPGKSTTKQMVLFTEHIYRSSDKKMTTDVIYVDAEKAFDKPKFERIQQELKDSKIDGKLLNLIMFLLVNRKFLVKINGKLSSQTEADSGVGQGSVLGPIIFIILLSKLSRLLNNIDGIIHFIFADDLKLVCTYFIKDYDQSIMQNALATVSDWCSNESMAVAAHKTFHVQFGTPNPQAIYSLNNSEIQRKDMTRDLGFFIRNDGSISQHLNVITRNVNRKMFSILKKITIKDPKMLIYIYNTYIRPNYEYGSQIFNVQKKKYTDQLEGNQRLFTRIVYKRNHPTTTVIPDYSARLKLYENGFPSPRDWRLISYWRMTCSLLILIRLVLTYDRIMKLRWYYSTSLLIKGSIQSFLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z066</accession>
    <name>A0A914Z066_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z066"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6130.t1">
        <property type="protein sequence ID" value="PSU_v2.g6130.t1"/>
        <property type="gene ID" value="PSU_v2.g6130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6130.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13813" checksum="1BB5E56220A17FE3" modified="2023-02-22" version="1">MQNFTIHVAGRLHCLFPPGGSHLQYLEQLLFDSRLTDNKHYYPIWHVCNYFQYGRLQRLLLNVGNFDSKEVIEKSFELLHRATCPGASITILMDQDIDDRLFEWTKRWQFKYSGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0G4</accession>
    <name>A0A914Z0G4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0G4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6218.t1">
        <property type="protein sequence ID" value="PSU_v2.g6218.t1"/>
        <property type="gene ID" value="PSU_v2.g6218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6218.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14019" checksum="1B7E111A94AAB210" modified="2023-02-22" version="1">MPKPVRRKKEEVWRVFIYLFFDFDDDDDDANTSTAHEGYFSDEEDNGSSDYASALSEDEEEEEYHPVIAPPPPSHHDDDRMQHTDEVTDRYLSHLFTPSIANITTATDEYTQNDTHSIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0K0</accession>
    <name>A0A914Z0K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0K0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5878.t1">
        <property type="protein sequence ID" value="PSU_v2.g5878.t1"/>
        <property type="gene ID" value="PSU_v2.g5878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5878.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16398" checksum="A9996C320BBA8AFC" modified="2023-02-22" version="1">MPSSTSFPCVDLESPSSSTSVIHPPTTRRTLPYRAVSQQFESPSDRPRSRRSSTRRAMRRLSQLFHRVRDQFIAHMPLWSPIEAPSLPLETPASAPGNLIALNGSKEASPFDLDDPKTTIVVAEELNQNTALEMETTVSLKWEYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1L2</accession>
    <name>A0A914Z1L2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1L2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6597.t1">
        <property type="protein sequence ID" value="PSU_v2.g6597.t1"/>
        <property type="gene ID" value="PSU_v2.g6597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000020">
        <property type="entry name" value="TBC1 domain family, member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF547">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="433"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6597.t1"/>
        </source>
    </evidence>
    <sequence length="752" mass="84985" checksum="575AD6E0913926BC" modified="2023-02-22" version="1">MTTLSDLFKKAHGALANLRGGNNVFFGKDGDIVYSKNNVCVHEVSENSGTVDDDDIVHTPGYLTIHCLNDEQTGVTLVLQWLPNTTLEKNPASIRCVSPRIQANRKGSAGNNQQQIKMKQESVESGEDTASISGVTQMGSECPSDVSTDICIEVNGDSSSLSVFSERPQNFGIANEGLFVPCINVIPNTPIDPRLLSPDDNIDANVAEVQSTGSGSTSGADEFSDKEDLVQSSSCDDSESDEKAQSNLQASENNSKNFACLIPTTPEQFAQEKNLILDTACRTDDANMLAMAKERVVFQQRPTNTSLFSVNLGKMRSMRLFYSNPEYTCGQLVIASPDSRYKILHFHHGGLDKLAQIFEQWNAIKSKSVKDGSPSPLPDKHLLICHPQIRQTELDPEDGLYTRVNWDFWKSYKNQDGSIDDNLTVRKAVYFASMDPALRREVWPFLLRVYPWTSTLEQRESLRNDLFLEYQNIKRKRMKKMEGSAKHLMQAIESSIVKDVVRTDRQNPFYAGENNPNMETMKDILMNYAAMFPDINYIQGMSDLLAPLLSTIRDEAATYWCFVGLMQQTLFSSAPGSENNMMDINLAFLRDLLKLMVPNFYDYVEKLGGDTLHFMFVHRWILLFFKREFPEVDALHIWEACWSKYRTSYFHLFVCAAIVSIYGDDVVSQELPHDEILLYFASLAMHMDATVVLKKARGLLYQFNRMERIPCSLAGLFEQDNSEQWSSHAAIERTFECNRKHGNDEPCPFMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Z0</accession>
    <name>A0A914Z1Z0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Z0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4270.t1">
        <property type="protein sequence ID" value="PSU_v2.g4270.t1"/>
        <property type="gene ID" value="PSU_v2.g4270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4270.t1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52802" checksum="CAE88F8829D2FBBA" modified="2023-02-22" version="1">MKRKFLAMAESQTLRHRAAGDATPARNENRVVSSSDDEELPTEEKLEKLTRILPQATDKLGSIIDDYLSALPERWRNWVVRGLVTLFMIALFGFLVNRGALWLMALVLLIQLKCFNEIINIGLIVYRGFDLPWFRTLSWYFLVTSNYFFFGEGLIDYWSIVLRKDEFLNFFVNYHRMISFIMYISGFVWFVLSLRKGYYMRQFSLFAWTHVSLLLIVSQSFMIVQNILQGLIWFLVPVSMIICCDIMSYIFGFFFGKTPLIKISPKKTWEGFIGGAISTIVFGLLLSNALIERPYFICPVESYNEEGNNCTFPPAFVEIDYTIPRPLHAVYKVIRKDPVVHMKPFLLHSVIMALFASIIGPFGGFFASGFKRAFKIKDFGDIIPGHGGLMDRFDCQLLMGTFVNIYIQTFIRVPNWNKIVQQILWLPVEDQLNIYNVLHQQLGDAGVLHQQLGDAGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2K1</accession>
    <name>A0A914Z2K1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MnmG N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2K1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g63.t1">
        <property type="protein sequence ID" value="PSU_v2.g63.t1"/>
        <property type="gene ID" value="PSU_v2.g63"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MnmG N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g63.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="17879" checksum="023DDCB4F946EBBB" modified="2023-02-22" version="1">MFYPDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGLMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKNSYRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z339</accession>
    <name>A0A914Z339_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RecQ-mediated genome instability protein 1 C-terminal OB-fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z339"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6468.t1">
        <property type="protein sequence ID" value="PSU_v2.g6468.t1"/>
        <property type="gene ID" value="PSU_v2.g6468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032199">
        <property type="entry name" value="RMI1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16099">
        <property type="entry name" value="RMI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ-mediated genome instability protein 1 C-terminal OB-fold" evidence="2">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6468.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="46698" checksum="F6C82250394CD577" modified="2023-02-22" version="1">MLPVRQPIFNDFVPETPAAAYGNVSLQNKTQIDNNGFKKPILPIKRPHNSDFVPETPAAVYNEIKKPSKSLAEINLGPKKVYQSLITSSKNFQRRSIFKNELPIKTELVDVKPTPSSFKRLPAEDTVVMSDSLTDFSADNDVQMNNSNDNDESDNTGGGSSQPKENTRKSFAELLAMESDDEFMEYIQANKASQNATPLRDETLPLPFSIDRDTIPRKRLAERPKTPPLYNPRKLNFSQPAGCIPRKKNLLEAADVEHGEKRKKVVFRNPLVEKYKDLKVVKLNIVMDQKKFWLCPERRMIQPIFCDPKDEIDLKNWSLMVKISDETFGDVGMVVDKELLTFLLGYNAAHLKKAIAEKDSNELEKCREKAQNLRKIFARLDLVLEVEFSPDSSSYPVIKKINNLAKSLDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3B3</accession>
    <name>A0A914Z3B3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z3B3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4740.t1">
        <property type="protein sequence ID" value="PSU_v2.g4740.t1"/>
        <property type="gene ID" value="PSU_v2.g4740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="212"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="418"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4740.t1"/>
        </source>
    </evidence>
    <sequence length="584" mass="66624" checksum="5AF75652EC747FF8" modified="2023-02-22" version="1">MFRTSICRCFRLTVTSRALPDTTINEQPSFNRRKNQADQFGLIGHKLAPQNERYDKYKLDDRFFKGNVVRKEFQVPSKPKLKQITLPSTMDTKKRKKLEKQHVDFAKHQKAYGVDKRTAPVIIECKRSDLNHYEGQRYPSHDLPLVSEHWDKAKYKGDWFIIKRLQKLPPAIVDPDDRDWEIFSHLLDYGIIKNIKEKLHFSKPTKIQFATLEDFSVPMHLFIAGETGSGKTIAFGAPVISELIKDKDRGINSKVIILTVSSFLRNQTTKMLQDLVTNFKEAPVIREGKKTTVFKSADDFDVLVATPSRAFTLLNSLPKPLPISTVVMDEADMLLDESFVESMSEFISVVPIRNSTINPKSSNGARVIFSSATCPNELQDLAEGIVDSSFLTYIKSNTLHRLLPNIEQKFLRIMHPERLEILKEILEKDLQATTNGRILIFCKDINRVHYVSDQLKAAGVECFIIAKGKSVIPNEARVIVATDAASRGLDLPLVNHVINFDFPRHMVDYVHRIGRVGRCNSSKRKSFVTSFVRSDLQISMVKEIERCARLNRPLRTIETDVAGMIKANRESHKTKSDEKEVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3X6</accession>
    <name>A0A914Z3X6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3X6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6706.t1">
        <property type="protein sequence ID" value="PSU_v2.g6706.t1"/>
        <property type="gene ID" value="PSU_v2.g6706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6706.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17006" checksum="F5AE4CF09D354A16" modified="2023-02-22" version="1">MSTLWTITKIVGKAFGIISLPIAFCECVGHPASVVGASMEPTLRGNDARWWLNDIVWLSKIHSFPKNGEIYTYTSPRDPKVHHVKRVTATPGEIIDVKNRPPMPLGPLEYWMSSDNVTVGQDSRNYGPVNMGLFQGKAMFILWPPSRFGSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z492</accession>
    <name>A0A914Z492_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z492"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5072.t1">
        <property type="protein sequence ID" value="PSU_v2.g5072.t1"/>
        <property type="gene ID" value="PSU_v2.g5072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="5">
        <location>
            <begin position="56"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5072.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20814" checksum="0D526014D99644E3" modified="2023-02-22" version="1">MDESYLIQATSSIGIITAAEVWGALRALETFSHLIYKDSDGQWWLKSATISDSPRFPHRGIMLDSSRHFLSVNIIKRQLDLMAQNKMNVFHWHLTDTEAFPYTSAKYPELSAKGAYTPKHVYSIDQIKDIIEFARLRGIRVIPEFDTPGHSGAWNAFKGLLSLCYDTNGKNTILRSFKFIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4W7</accession>
    <name>A0A914Z4W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4W7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5302.t1">
        <property type="protein sequence ID" value="PSU_v2.g5302.t1"/>
        <property type="gene ID" value="PSU_v2.g5302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037668333" evidence="2">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5302.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="14883" checksum="4EA63981135DC3C6" modified="2023-02-22" version="1">MKLLFVTLLIVGIVCVASKPHRHSRRPPPSGPPPSHRPPPPHHHHTGSPRPSGPPPSGFPCIPQNSRRHHHHHSLPPCPPSSSTAIPSTDLPSEHPSSEAPIITDSPVVTDSPITDATTSNPPSPTSSSEVPSTESTNGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z530</accession>
    <name>A0A914Z530_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z530"/>
    <dbReference type="WBParaSite" id="PSU_v2.g779.t1">
        <property type="protein sequence ID" value="PSU_v2.g779.t1"/>
        <property type="gene ID" value="PSU_v2.g779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g779.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="6762" checksum="B44651B8C867EED2" modified="2023-02-22" version="1">MDGFKVLADDLWRDMVQMGAGTPSNRIRRESYGGYGASGSNTGGYGGGPSSPGGPGGSGQPTLPGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6V0</accession>
    <name>A0A914Z6V0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6V0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8420.t1">
        <property type="protein sequence ID" value="PSU_v2.g8420.t1"/>
        <property type="gene ID" value="PSU_v2.g8420"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8420.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22597" checksum="576999AB6DE97415" modified="2023-02-22" version="1">MDRLSMYYPTRMIKQIGMIGEGNFCQVQKVEQVGPEGDERVAAMKACHVSNELKGTQAGRMASIEILHEARILAGFSNYTFITMFYGICFDEPIPKLIMELCPYGSVESYVTNKEVTITTAEKILIAHDIACGMQHLEECFCVHRDLAARNCLISAKGIVKVADFGLSRQARELESEKLRFNEFKARKFFLYIKGLKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8G4</accession>
    <name>A0A914Z8G4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8G4"/>
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        <property type="protein sequence ID" value="PSU_v2.g6542.t1"/>
        <property type="gene ID" value="PSU_v2.g6542"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
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        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
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        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
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        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF26">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="131"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="308"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6542.t1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45863" checksum="0931F4ACE849D84B" modified="2023-02-22" version="1">MPAKISVMDKNNNEPIKKASETSSATTRSSEETRITSSSSGETTTYLPTPNVVSSDSFTRRMSQFSTPSNFVLKPGEYLHDLREGIDRTLLSYANNLKAMSVYDIFLDYTRVISQDCKQPAPTFNKNEIFNRYRDIRCIETTRVKIASPADGNDYIHANYVDGFRELKKYILTQAPFHSTLDKFWEMIWQEKSTSIVSLTVLDGEKVAVYIPTKSGEAFIFGRIKIVNMGTRHIRDTYDATVLMITKGDEPARKLFHIAFHSWPDKGTPTQPTEVLHMLDDMNYNRKLLIDEAKKKGWLPNVDMPCSPIIVHCLAGVGRSGALVATEICQRKLDYSYNRNCGPCVDVRDTVLRLRTQREMIVQKPEQYLFVHLTVFEYAVRKRYFHSIENVNLTSFVTSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8L0</accession>
    <name>A0A914Z8L0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8L0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8245.t1">
        <property type="protein sequence ID" value="PSU_v2.g8245.t1"/>
        <property type="gene ID" value="PSU_v2.g8245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8245.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22878" checksum="912D6B28B95EBF6D" modified="2023-02-22" version="1">MADKKLHTADSESTTDKVIEKSDSAEMPPFKKEEKFFVPLNFFGLLILKNERMKSIEEKNNVKLIILPAENSSTEKVGLQILQINGDPKDVEKAVLVIQNILEEDDGKNRLKRILPKQRSKDGSEFECPICCETFNISDDECVKCTPTDIFEQSTATSATTNESHSICISCIQEYARSAITGRVAVGGLGLNCVSDGCKNHHLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8R9</accession>
    <name>A0A914Z8R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8R9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8728.t1">
        <property type="protein sequence ID" value="PSU_v2.g8728.t1"/>
        <property type="gene ID" value="PSU_v2.g8728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8728.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11413" checksum="F9EF96D9888EFD83" modified="2023-02-22" version="1">MAYRVHPALNAAYEKLQEKPAPKLIIQVIDTSTNSVDCFIPLESIENFLDVQYMTPDEMVGKLARKKFDSDEESSESEPDVSDNEAEEKSDKEEEEEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8Z9</accession>
    <name>A0A914Z8Z9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8Z9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8300.t1">
        <property type="protein sequence ID" value="PSU_v2.g8300.t1"/>
        <property type="gene ID" value="PSU_v2.g8300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 38 C-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 38 C-terminal" evidence="2">
        <location>
            <begin position="263"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8300.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38719" checksum="0BB28B800EAE3A23" modified="2023-02-22" version="1">MQSLLAYKGHDNVGEASGAYIFRPQVNIPDVVNAQPALTLTYLEARQVYSDWLSQTIRLIPNKTFIEFEWTVGPIPKTNENFHNYGKEVIARYEAPTIQSGKQFYTDSNGRQMILRIRDYNADFQVDNSGEPVAANMYPINSRAMIKDASTAFTVLTDRSQAGGSIINSTIDLLLHRRDFYDDGWGVNEALNEPGSDGRGLVVRGRHRIFFSDPSSAAALHRQAAFEIFHSPIISFANYDNVPNYASKYPTTFSGLATSLPSNVHLLTLKQLDASTLLIRLEHIFAKNEDSVLSNPATVDLTTLFKQFKIVSAQELTLGANMVVSGSASTTVTLNPQDIKTYQVTVTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA43</accession>
    <name>A0A914ZA43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA43"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8656.t1">
        <property type="protein sequence ID" value="PSU_v2.g8656.t1"/>
        <property type="gene ID" value="PSU_v2.g8656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8656.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18575" checksum="923E80B4B1C08F03" modified="2023-02-22" version="1">MIFDATCKQDLQWKIALERPRTEKDENFFEFCTKVQHMIDIFPRLAPDDLTSGKCYFIKYGGRYYRGVFISLSRDNRHAIFDFADFDGVRPIPFKDIRPFPKRNEICVPFMIFWVYTNECNFKENDRVYCKFSGTFENTSYRKFYQAKVQKIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAG2</accession>
    <name>A0A914ZAG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAG2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8771.t1">
        <property type="protein sequence ID" value="PSU_v2.g8771.t1"/>
        <property type="gene ID" value="PSU_v2.g8771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8771.t1"/>
        </source>
    </evidence>
    <sequence length="883" mass="98080" checksum="F4E3D8F296D242F9" modified="2023-02-22" version="1">MSELVSFLQRTISGSQSDQQAALSFLQQAAQTNFPEFVKQLSIVLSSTDVEPFVRQQSGLQLKNLLYAKDAETLQQNQKRWIDTPEDIRNTTKQNVLRTLGTETVRPSIAAQCINAIAGIELPFQQWVEVIEILMSNVTNDSSSEKLKDSSLEALGYICQDVNTSAVESKSNQILTAIVHGMRQQESSALVRLSATEAMLNALELTKNNFANTDERNVIMRVVCEATQAPDTRIRVAALQCLVRIVSLYYNHMDMYMKEALFAITVDAMKSTDNNVCLQGIEFWSNVCEEELVLACQEIEAREEGRTPNVVSRYYAKGALQHILPLLLNTLARQEEDDDEDEWVPAKASGVCIMLLAQCTQDEIVPLILPFIQQHFENPDWHFREAAIMAFGSILDGPSQEILNQLVGGAIMPLIRTLADPHMVVRDTSAWAIGRVCDSCESLVTREEVLRDLVPALFKALEQEPRVAFNACWALSSLVKAAYQISKDQGTDETGEPETYVLSPVFEEMVKRLIITTDRPDAGENNLRISGYEALMELIKNSPKDCYLHIQRTTVDVLQRLQRVLGIEDGAISTSDRSQLRDLQSLLCATLQSVLRKIKKEDAGQISDSVMSALLHIMQRCSSGHDAGGVMEDALMAVSTLIEVMGVNFAKYMEQFKPFLFHALRSHEEHQICQAAIGVISDLCHAFEDKIAPLMDDMVALLLQILQDANVKHAVKPHALGCFGDIAIALGPNYNRYLNYTVEYLMNAVNAAQITNPDDLEQVEYVESLRDNCISGFTGIVQAMRSSQEGLQQLIPVVPQMVKLIAMVAESGSLSSDDLQGTTCGLIGDLIDVLGKDIFPLLDTPAINALLQRCRRSKIQKAKALGVWASRELSHLKRQANAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBH4</accession>
    <name>A0A914ZBH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBH4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9098.t1">
        <property type="protein sequence ID" value="PSU_v2.g9098.t1"/>
        <property type="gene ID" value="PSU_v2.g9098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9098.t1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48338" checksum="89BC4CA3B051E237" modified="2023-02-22" version="1">MNFIDFKAQTSVTKNIERQRLRRHGETQNYYNQEGSLTLSKTPEDRHHGDLPYSPRRRFESDFERMGRMRRIKSESALGGEESDEENYGTSNRRLKRFGEHEHSDYATPPPTSYHGSGHNNNLMFNTKMSQSIHDLSMAHMTSPTLSEAMPRRSAEAPGKFYTGNANGMLYNGQNNNAESATMNRILRRTVSPAYSNSSSQFDNGGLPGYPSSQIPPPHGGFSYLFPTLPIVDRIVGRSKTPEVYAENHAISPQENNILPPRIESSNSNNYDYQSVASPRSHPIHISQGSDPSTNVVYIPINMIEKKPVMLSPRSIQVSSNHKFSDHHRTANLSPNQSTNEPPFNQKYDKRRQTDNGLFETENLQNDNIKQENNIIKRTPHYSGSTNLGEDVRDALREFDYLNDYDESSVRNDTIPHNPTAIYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC78</accession>
    <name>A0A914ZC78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9529.t1">
        <property type="protein sequence ID" value="PSU_v2.g9529.t1"/>
        <property type="gene ID" value="PSU_v2.g9529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9529.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28168" checksum="3B70A70AB3FA0BA3" modified="2023-02-22" version="1">MIDQAHPDLTEDGLINFEKRRKEFEVLAKIKLFQSAARAYNVPMDKGFCAWFFYLPAMAENECFTRSLEVERTTNSTPDLRRIIPRYSSGNIMALATHAVPIPKINTLSRMFNNFSMSAESNPDSPMKGSPTLAGQTSNDSGIHTEDSWASNSSGDPIQPTANSAALTLLARGKVLATCAGPPGSSNSNRSFTAPSTPQSTLSWRGGSEFNPYTHQHQNSNGGGEPVGVSFTFILFSLKIFLILQSPFFFIFIGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDM1</accession>
    <name>A0A914ZDM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDM1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8367.t1">
        <property type="protein sequence ID" value="PSU_v2.g8367.t1"/>
        <property type="gene ID" value="PSU_v2.g8367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02910">
        <property type="entry name" value="cupin_Yhhw_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000021">
        <property type="entry name" value="Quercetin 2,3-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8367.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20469" checksum="009C6A3D28CF0893" modified="2023-02-22" version="1">MIYLRKANERGHAERDWLESWHTFSFSSYQDPNFMGFSVLRVINEDFVKPGTGFGTHPHEDMEILTYVLHGTIEHKDSMGNTEKIPAGEFQIMSAGTGVRHSEYNPSNETPLHLYQIWIEPNVLGIEPRYDQRKFEDIKGQQLILTPDGRDGSIKVFQDATLSRWIDDIGFKLLKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDT6</accession>
    <name>A0A914ZDT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDT6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9840.t1">
        <property type="protein sequence ID" value="PSU_v2.g9840.t1"/>
        <property type="gene ID" value="PSU_v2.g9840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="384"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9840.t1"/>
        </source>
    </evidence>
    <sequence length="492" mass="56478" checksum="ED51B62AA4EC8298" modified="2023-02-22" version="1">MREIISSIASLYIIGLYFNVVIADTAKEVEKHLELGKQFLAKGQFPEALQQYHAAIELDPTNYQTYYRRATVLLASGKVKAALPDLDKVVELKPDFIAALTQRGNLLIKQGKFNEAAADFKRVLKTDSNNSDVKEKLSHIDQLREWTEQANDFYENNDFHNAEALLDKVLELCLWDPDLHRLRAKCRQARGDIQNAISDIRAISKLVPDSTEAYLEISNMYYNIGDIQNSLSQVRECLKLNPDHKECFPFYKKAKKLQKMRDSLEEFVTKEKWTECLEKGQQILKFEKDVDNVQLDVFRHTCKCNLHAGHVAEAINECTEVLKYGDENDLDVLCDRAEAYIVSEDFDKAIDDFQKALTAHDGNRRAKEGLQRAQKLLKQSKKRDYYKILGVRRNANKQQINKAYRKLAQQWHPDNFREDEEKKKAQEKFIDIAAAKDVLTDPEKRQQFDQGIDPLDPEAQQHGHGHGGNPFEHGFPFGAGGGDGAYSFKFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEK0</accession>
    <name>A0A914ZEK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZEK0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8706.t1">
        <property type="protein sequence ID" value="PSU_v2.g8706.t1"/>
        <property type="gene ID" value="PSU_v2.g8706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF13">
        <property type="entry name" value="LD36653P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8706.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22792" checksum="B71BC44B839A1BF0" modified="2023-02-22" version="1">MKDHLIRVNSIASSSIDEPTDIIELRSRGRNQGYGSSGGGGNVQRYDESSSPTWLGNRVLIERKIQPGDTLNKIALQYSVQISDLKRANTLLVNDQDIYALPVIKIPVSRLFADRIEAESRNQVEPYRHQTTAAIVPITNDDRRPLLDTDDDEDSDEHIRKAKVGALLQKTDANITQVRGNLPSPGIEGGAFHFVDATSPDTTMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGK8</accession>
    <name>A0A914ZGK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Recombinase A</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZGK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9420.t1">
        <property type="protein sequence ID" value="PSU_v2.g9420.t1"/>
        <property type="gene ID" value="PSU_v2.g9420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000087">
        <property type="entry name" value="Recombinase RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049261">
        <property type="entry name" value="RecA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049428">
        <property type="entry name" value="RecA-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900:SF1">
        <property type="entry name" value="MITOCHONDRIAL DNA REPAIR PROTEIN RECA HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="RECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21096">
        <property type="entry name" value="RecA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="RecA protein, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="145"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="309"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9420.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="49256" checksum="B76B9AC881994473" modified="2023-02-22" version="1">MIGVREETLAQHGAVSEPVVVEMAIGALKAARADYAVSISGIAGPDGGSEEKPVGTVWFAFATARGEGITRRECFSGDRDAVRRQATAIIASTEHIDYPVLPGMTGVKMAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLSNPNSTPDFSVDDSEGVAETNEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XPS7</accession>
    <name>A0A914XPS7_9BILA</name>
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        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g10015.t1"/>
        <property type="gene ID" value="PSU_v2.g10015"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10015.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15125" checksum="AFDAE0475FAB0369" modified="2023-02-22" version="1">METRDCSQFTSDLININVQDELNKGTLLHYACKFGEIEAVKYLIKNGANRFIEDSNGETPIFYILKFCDNVDLIRTVLGVDESFPHISELLLHKNFENFDVMQIAIQNGRRNIANYLLQKFPEFYGIVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQE9</accession>
    <name>A0A914XQE9_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XQE9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10235.t1">
        <property type="protein sequence ID" value="PSU_v2.g10235.t1"/>
        <property type="gene ID" value="PSU_v2.g10235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10235.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12875" checksum="AF5B555DB0031A4F" modified="2023-02-22" version="1">MPIVHCCLIFRKYTEEQKSQFLQECEERNFEFLTNFKVGKSVHYSTSTDEFNERDETEFSFDLKPLAELGLDSKDKYEGIVLAEADLVTTFEALQRTFKNNGLADDAALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XR70</accession>
    <name>A0A914XR70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XR70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10494.t1">
        <property type="protein sequence ID" value="PSU_v2.g10494.t1"/>
        <property type="gene ID" value="PSU_v2.g10494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10494.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10296" checksum="DAFC986792285A51" modified="2023-02-22" version="1">MTSFGIIYNVRYLPPMRRHINEASEKFAQRIQERIADASNIDAIPFDLNVLKRITEQKRIHDYSQNQCAHMISTLYAAKYGPMIMHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS21</accession>
    <name>A0A914XS21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XS21"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10789.t1">
        <property type="protein sequence ID" value="PSU_v2.g10789.t1"/>
        <property type="gene ID" value="PSU_v2.g10789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10789.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9053" checksum="2C68C4CD63861D69" modified="2023-02-22" version="1">MIKILKYTPTERLSGPKILAHSWFKEIFDPATKRYNGKSINILSMNDYRNAIGGDRESDDAGTSATGSKSNEDDDNENNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTE6</accession>
    <name>A0A914XTE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11230.t1">
        <property type="protein sequence ID" value="PSU_v2.g11230.t1"/>
        <property type="gene ID" value="PSU_v2.g11230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="96"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11230.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22964" checksum="99392E2C674F18A0" modified="2023-02-22" version="1">MDKSDRMLNIDTNWEQDIKPDISSLGPPLKRMATEPLVSQNYCASEGSPFSNSSNVSRRSEEPIKTTRKYHSRCTDGSTPRSGRGRRSITTEMPADERRQTILERNKAAAVRYRKRKKEEHDEMITRVNLLEQDKGSIVTQNSVLRREVERLTELLKLRDARCVCHAAANLPGTNNQSILASLPPEPPEQQHAFNLHMNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUN9</accession>
    <name>A0A914XUN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUN9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11661.t1">
        <property type="protein sequence ID" value="PSU_v2.g11661.t1"/>
        <property type="gene ID" value="PSU_v2.g11661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11661.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14924" checksum="DCD5E28CF0797525" modified="2023-02-22" version="1">MSIKVLNRDKQIQVLRQEFVYLFVNENGLRFVCEICKDFQVNVYIDKTNLQEFELDEPFECLLKMDQLFASMIMKNATCMELIFEETENQIKLFRVNMEAPNVRTTLKLHTFNGGQVGAYFNQLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV83</accession>
    <name>A0A914XV83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">3',5'-cyclic-nucleotide phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XV83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10879.t1">
        <property type="protein sequence ID" value="PSU_v2.g10879.t1"/>
        <property type="gene ID" value="PSU_v2.g10879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10879.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37108" checksum="131E3189BC193790" modified="2023-02-22" version="1">MGDVKSSLTDLERFSLLVACLCHDIDHRGTTNAFQLQSKTPLAQLYSSEGSVLERHHFAQTVTILGMDECNIFEQLTRQQYQQVLDNIREIILATDIAAHLRKVDRIQAMVESKLFSKFKIFLKIIHVLVGFDKDSIDHHYLLMCLLMTASDLSDQSKDFKNSKGIAENIYKEFFSQGDLEKQMGNRPIEMMDRERACVPKIQLEFMDTVALPVFRYISDLLPALHETYDSLMINRACWQSLDCILQEEGLPSGGLDYLKDIDLEQKVLDRVGDRGLAWKEEYARKDGNKEATAPTNPSNSTKSSVTSKSSQDTAPDDKPCSSKSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV98</accession>
    <name>A0A914XV98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage major capsid protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XV98"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1116.t1">
        <property type="protein sequence ID" value="PSU_v2.g1116.t1"/>
        <property type="gene ID" value="PSU_v2.g1116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054612">
        <property type="entry name" value="Phage_capsid-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01554">
        <property type="entry name" value="major_cap_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05065">
        <property type="entry name" value="Phage_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56563">
        <property type="entry name" value="Major capsid protein gp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage capsid-like C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1116.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8342" checksum="4564FA0E53E4AB48" modified="2023-02-22" version="1">MGFGLVEAEDMPDIATDSTPIAFGDFARGYLIVDRIGIRILRDPYSAKPYVLFYTTKRVGGGVQDFDAIKLLKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW13</accession>
    <name>A0A914XW13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XW13"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11423.t1">
        <property type="protein sequence ID" value="PSU_v2.g11423.t1"/>
        <property type="gene ID" value="PSU_v2.g11423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11423.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15721" checksum="6E3721D9342F9D83" modified="2023-02-22" version="1">MTETLPPKTKQPSDLLQDDKDIQQAIKDAEEEAKKRKEMESKTKWRRIKETLVEWGSISSCHVVCFSIFLYLFIDTLVQFLSFEKLVELQMDLDEMVFPSVTICNINPYKESAIEQNEQLKALLTVYDEVVNKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWD3</accession>
    <name>A0A914XWD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWD3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1154.t1">
        <property type="protein sequence ID" value="PSU_v2.g1154.t1"/>
        <property type="gene ID" value="PSU_v2.g1154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1154.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26727" checksum="87A3379BE122EA6A" modified="2023-02-22" version="1">MPKLSSDILREVFYEIVKGNGSFKNVDKFMMIGREPFELVLDICREAQNVVFLKDKIVAKLPNIDYIRYDSDDNDTDESDSIGNDSELYNGTLSDIDNYHYNSDSDSDSDSDDEDYIFGTVIPHKFFFIKPISVALASVITSLNLKSFIPAFIPMLKAINKELKEVNIQDVDKQLSVIFEACVNIPNVVDGVTIQLCSNYNFSKQIKAFAIPSRKLTIKNAYFNYFYHGKKFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWN7</accession>
    <name>A0A914XWN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1236.t1">
        <property type="protein sequence ID" value="PSU_v2.g1236.t1"/>
        <property type="gene ID" value="PSU_v2.g1236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF5">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037309612" evidence="1">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1236.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16218" checksum="3573DAECA0BAA5A3" modified="2023-02-22" version="1">MANFFFFGFVLIFTVTVVLSNETQTFNPKLEWICETFFISLTVKTDLPFHGIIHSSGHRSDCAIAGNGTILTNMIIPFGGKNDKCGVKFNTISETYWVEITVHYHKILETEYDRIFNVTCDKNIIVSEPEFNFLLIFIEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX02</accession>
    <name>A0A914XX02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11058.t1">
        <property type="protein sequence ID" value="PSU_v2.g11058.t1"/>
        <property type="gene ID" value="PSU_v2.g11058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11058.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17214" checksum="07525F2585D54B70" modified="2023-02-22" version="1">MNDPDYPYGEHICSFETNPECETSSVYAKRAILEANMDMRVNPERPLAKYVKMLTFFEEDNGKYGHLDAETKRRAQTILNQVGNGFNARKRGLMLNYQLGKKKLLKQDKALNESLDVNMTENEGDESVATPANVKSEIGQDDDLSKIRKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXF9</accession>
    <name>A0A914XXF9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXF9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12636.t1">
        <property type="protein sequence ID" value="PSU_v2.g12636.t1"/>
        <property type="gene ID" value="PSU_v2.g12636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="161"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12636.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29730" checksum="67240490AA52D6B2" modified="2023-02-22" version="1">MLIDILNHPDLPSTNISSLRGGIIGGAGTPGELCQKIYKNLGMQKYVNSFGSTETTMTAVSNPEDKNIVKPMYVMPHMEMAIINKCGKFVSRGEKGEIVVRGYSIMQGYWNDEEKTKEVFDKDRWFHTGDIGSMSSDGSIEISGRYKDVIVRGGFNYYPAEIEQFIVQHPFVADACVIGVPDKLHGEEVCAWIRLKSDTSLTVDELVEFLENRISTSKIPRYILFKLQHEFPLTPSGKIKKYELQKLSIKELKLEKVTSYCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXI4</accession>
    <name>A0A914XXI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1167.t1">
        <property type="protein sequence ID" value="PSU_v2.g1167.t1"/>
        <property type="gene ID" value="PSU_v2.g1167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1167.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19518" checksum="2DD3ACF90DB6BCD0" modified="2023-02-22" version="1">MQSYQIGQNYSGNGVNDKITNITRQDEEMKESCRDINNAQTQPQSHSQTPIPITNTHTPHTTSLIDQRVLRFLPNRFKYFFIGYHSSPERDWNEPKSKHCCGKSLEKNVCESGCKCPIPGDEFEVREHEQERCFKILWEKGIYQLLAAIGDGDEFNINEIFEAFRNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY12</accession>
    <name>A0A914XY12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10603.t1">
        <property type="protein sequence ID" value="PSU_v2.g10603.t1"/>
        <property type="gene ID" value="PSU_v2.g10603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR DMSR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10603.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20198" checksum="65D49A605E098319" modified="2023-02-22" version="1">MAVLSGMFSEEFRRYVYNNLGDLLDLSALCNSCTTFVIYCTMSAQFRNEFRRVFVPAKVRCWLSPDRRCSNAYIPSFTAANKSQVTYLRPSLNGETNDHSITLTVVGSTNSVRKFNSNGNTPLPSPQPSPAMLTTMENHGHLSAAPTDYNSGGSMASTLTVDGAEGDERAKLLKDSIQRNGSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYS0</accession>
    <name>A0A914XYS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYS0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12098.t1">
        <property type="protein sequence ID" value="PSU_v2.g12098.t1"/>
        <property type="gene ID" value="PSU_v2.g12098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12098.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15443" checksum="8461AC013C33277E" modified="2023-02-22" version="1">MPPAYTRIDYSHDSIESNTPRIHPHGPVITVEDTGSQVNLSFPKGSGMASPVPESLVSSIDRGYGGGGGGGNGENGAPGNNSLTVAPQTSKNNLNRNNSRYGVPIDESAVKLVYKQRSQRLNTRVQITDRCLILAITGLQNKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYY6</accession>
    <name>A0A914XYY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11750.t1">
        <property type="protein sequence ID" value="PSU_v2.g11750.t1"/>
        <property type="gene ID" value="PSU_v2.g11750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11750.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21928" checksum="C3D38243B3C3D626" modified="2023-02-22" version="1">MYCHVTSPTIIFTDIYVASVCNTALRGLFHEYDTYVSNGSLKIRDFTSEINQIELIYGREVLFAEFGAILIPRSLSPIFAFGGLNGKKEVYGMGSIKYGITGFAENRYACWTLHLDFSIYVQQILYAKCVRGQFQIVPKADKKRRLAINTGAMVVRMVERDFGGDDPVRMFPDITFFNFDNFLSLNPGNNPGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZP4</accession>
    <name>A0A914XZP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Mre11 DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12675.t1">
        <property type="protein sequence ID" value="PSU_v2.g12675.t1"/>
        <property type="gene ID" value="PSU_v2.g12675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="17">
        <location>
            <begin position="297"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12675.t1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56682" checksum="B2CAD98F6ECF446F" modified="2023-02-22" version="1">MSDFQNTIRILIASDIHAGYGEGKKIIDEDSFIGLEETLKHATEQDVDFILLGGDLFHESVPSRYTEHKVISLLRKYCLSDREIAIEMISDPQEVFENNHFKLVNYEDPNINVGMPIFSIHGNHDDFSGKGLMALDILHDAGLVNLFGKFNNVDNIVVKPILLRKGDAKVALYGIGSQRDDRLQRAFHAGKVKFCFPEDVDDWFNILVVHQNRPPRSLTRTTGSFLPLSVLPSQMNLIIWGHEHKCEIEPQFFPKGTGNEKDGFFIIQPGSTVATSICADETSAKHVSVLEIKGVTFKTQPIPLQQTRQIIVEDLDLAKVNPKPRIVKLKARTKDMEDERLIHEKLQEMLENAKQYRGAQQPNLPRMRLRVIYSGDWLKIPPVNCRVIGHKYDGKVANPSDIVSVKTIRPDDVDEKGVRKVTASDGTTVHDLLKQSFTDNDIESGLGVLSLSKMQHYVDVSTKLDESKKKKLEMLDNTINEQIAEYKAKISKVSLRSVCFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y152</accession>
    <name>A0A914Y152_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y152"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13182.t1">
        <property type="protein sequence ID" value="PSU_v2.g13182.t1"/>
        <property type="gene ID" value="PSU_v2.g13182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13182.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23936" checksum="2E3DC9CAAC6F3B6E" modified="2023-02-22" version="1">MNPHTCYDVELIFLKKHRMKRPDERLTIYFNDMEDLHKMRKEFGKDKIDITRHYAGRITVGIFIQNWEFKHELRRKNKFDHEVKEAEKRAIIYASDSKLDANYNYKDSPPSPSENLSKVSKAPKDPMDSSSSNSSKKRRLKENEEKERRQKKKKEKEEKEKKRGKKDGLIKADKNNTMESKEQTSKASVSRETTKEGPKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y168</accession>
    <name>A0A914Y168_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g11580.t1">
        <property type="protein sequence ID" value="PSU_v2.g11580.t1"/>
        <property type="gene ID" value="PSU_v2.g11580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1466"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="623"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="724"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="866"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11580.t1"/>
        </source>
    </evidence>
    <sequence length="1716" mass="195748" checksum="343550BC92E29604" modified="2023-02-22" version="1">MPSPTNGFKRENVTPPGRTRLTGSTPSLSSPSSNAITTLLSNASMNASFPSTSDTNYFITPAIGRHRFSPSSSASVTPKKSILKRSSFPLPTGKVAFESPFTTFATNALLPPSRNNNFEQQKNNSNNNNNNVSRIPKPSVGFSEKNTVAIFGDTSDDNTTENESLAQANSRIPIPATNPLDKLIRQTSILYSEDEDTDSPSQPAGDSHDGTDYEDDTATEDLENVVIVEEKKENGGTDDGDISYTSSTASSLVTSKWWFGKETKYVTHCDKNGCNHKHHKHQQSPPGAYLTPTQQKSKEINKLKKELKGAKSVVEEKERHLRELRDRVKEIENVMDTNSALREHSRLMQRQKEIQDEYKAEKQQMIEKHEIRVRQLIQEAVDARADALRRTEQLEQFHKLKRQNYVDSSTNTDPPKPPPSHAVGLQAALASLAPSPQPDDGSTSEQHHHHQQQQQVQAAIAQDAVNQLQAYQNEAIIWRTKAAQLEIVVKEQLSKASTTEAILANDLEAARIETERLRDYCHRLEAAALADSICDGDRLDTAAMIRSIDSSSRATPANQQLLQSPSSVHLVLAAECQSPACLERTRLLGEENKQLYESLQERAGRIHELEEAVTDLRQSGEDMIFEMEDLKEQQQRLAQLAEERNAECEAAQIILSRLQDEKEQLNQALLFLEERTKVYRNTILDNDLVVRDEGTSEWHRGFIDPRFQILVSKQAQTDLTSDELKSNEREFVDLREKLREIQAEFSSKHKTLHEKFNEIEENLILKTNLVESLSRQLDSAQDEIQQSLEQRQKERETYQQRINNLAKTGERIPFLEAEHERMKSEKSLLERRFEEMKEEYEDGLGAALDGTLRKYKEQTLYWQEKVSKLEQSRNLAKAENEKYRKDLELIKMKNYLNKADLENRLTSSIDHVTILHNQVNVPRRDAQCDARPKTNSKYVSCKPNVKEKETQIFKGELFDEIEERLKLTKVELSVTKRQVQVLQQKMLEGTTPTTTMNNSGSHGRGSGDDRDTTYQGTPRPSPFRSTVSPIGTVERNSSFMFSVFDHSINNEGRNFSIAETEDIEDLKENISQLEERNTELSTKLRHSEAVRNEQIRAEKERLQQIFNEFDNVRKELDEEIKKYESERMKMKEKIQKLEQQKDESDKLKAKIRQWNKLHRLLAPRISATSDSNDENEIEKAIEKMHHSMFSAHPIEENNSEEELKRSASFPALLITSADSDSEIGEEVLSETDSRKQQPKNSEKAEELNETKLLSAELSRLKAKVEQSIRRTVSQNSATTSGAASGSLSPLTAKIVETSPIPAFAEFSTDLEQVQAELEKLLISMETPPTVTSTVTLDDSKLEKITVENERIKKAFTELKSNYDEAARELDMYRNETAAAVLDRKDNPRFPRSNSSENLINTSVTPQELQRWKETAGTTFREVNRLRKNCAGLENDRRELKTQVAILKGEIELAKAQNQLNKELTEVSRRGSFQSHKSKRQRKSTDRKARTQSLSTTTGSYATANYSFASMDVLLSNSEPNIFDQWNSSEQININSMNEKKHSLEIISKVNPEDELSIVQEAFQKQVSALKTRNAELEKLLASKNSKLIRQPLSRSQEAIAPLPNPAEKQQEEKLAILEREVKLYEKKIREMDDERQTMNLVMFQKGQQAAKHDLTEEKRIDEMTEDRIVLKFLHDAFYYYLLNRGNTREHLNAIMTMLNFTSSQKDEVCKRRGNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1F8</accession>
    <name>A0A914Y1F8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1F8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12621.t1">
        <property type="protein sequence ID" value="PSU_v2.g12621.t1"/>
        <property type="gene ID" value="PSU_v2.g12621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12621.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22301" checksum="3DF8B104AA7E5850" modified="2023-02-22" version="1">MNENRRPRKKLDLVGNPVVPPDTSPSVSLSDTTPSENVAEPLPHKDISQLQLSHVRHMAELKKVKSRSKGKENKARSIRMKMIHQQRKLQINATESEGFNINIGSDDQGPPGFVSLTPLPVAGFIPLHSLNLQPSVNQTTVTSQPSPIIAKNPLSGTNKYKELKSVREHVAAVLPEYQIVNNPLKKWSIEEAAKWKNICGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1Q4</accession>
    <name>A0A914Y1Q4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1Q4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11751.t1">
        <property type="protein sequence ID" value="PSU_v2.g11751.t1"/>
        <property type="gene ID" value="PSU_v2.g11751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="579"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="698"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11751.t1"/>
        </source>
    </evidence>
    <sequence length="768" mass="86135" checksum="47A3C1C02C694E45" modified="2023-02-22" version="1">MLENNFKVSFNSTLYILSLDPNEDPVTGLARVSSLNSIQTIARRNDRRRWEQERIIQRHISVIDHDHILSEKFESLDYEIIENELYRDEESHKDHQRKLFRQSVNRWVVCFLIGIVTALVAAFIDIMVYYSAQIKFHVIIHALTEKCDHEKIKGGGCIWMVLSAWTFYNCFLVGIAAVLVVYFAPASAGSGIPQIKCFLNGIQIPGVVRLKTLISKAIGVSCAVGGGLAAGKEGPMIHSGAVVAAGISQGRCVSFPMDFKIFEYFRNDKEKRDFVSAGAAAGVAAAFGAPIGGVLFSLEEGASFWNQSLTWRMDNSFNIWEIPAFCIIAVIGGLLGALFNSLNVRITKYRKFYIRTNFQKIFECLLVAATSAFVGFITIFVVDDCKPIGINPNLTEVTKLWCPKGQYSAVASLFFQNPEESVKSLFHSPINSFRPMTLFIFAIEYFLLSLWTFGLNVPSGVFIPTLLTGAAWGRLFGIGVEYLFPDVTGIDTGKYALAGAAAQLGGVVRMTISLTAIIVEATKDITFGMPIMLVLMITKFVGDLFNEGLYDLHIELAEIPFLGWHPPKVCRNILAQTVMRKDVVALEPVESVQRLVEIIRTTRHHGFPIVDMITAPQSAQDFPDYGHLKGILLRSQIIVLLKKRHFTKDYRGKIPAEGAQNVSLADFRSDYPRNESNIPMLNLTPEDMKCFVNLKPFWHPSPHRVPLNASLNSVFVSFRGLGLRYMLVVDDNNKLRGIITRKDIARFKERRVKNQYLVNEVYISHFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1X9</accession>
    <name>A0A914Y1X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1X9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11816.t1">
        <property type="protein sequence ID" value="PSU_v2.g11816.t1"/>
        <property type="gene ID" value="PSU_v2.g11816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11816.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="14164" checksum="08094E17EC8344B6" modified="2023-02-22" version="1">MRNIFLKVSLNLIVLKQFCENELEKRWKKFEENFCENAFSLVERGYKYVEECNNLEIEGLKIYEHPWWHDFQQHYPTQQENDCDETYKTFVDFVKDKVAKQRRKTYGTKKSQKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2E0</accession>
    <name>A0A914Y2E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2E0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13404.t1">
        <property type="protein sequence ID" value="PSU_v2.g13404.t1"/>
        <property type="gene ID" value="PSU_v2.g13404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13404.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13457" checksum="72595E6C27F3C1A6" modified="2023-02-22" version="1">MGDNPVNLENPGRRCFKLENASFQAYDKDTSKNVMKLEASGSIGCQIFMELPQYMQIEDFPLPNAPYLVLNSTFDGNNASFWWKKDNDKMIPSAVSFDGSGNVEINIFNSTKDIPFSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y361</accession>
    <name>A0A914Y361_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y361"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13889.t1">
        <property type="protein sequence ID" value="PSU_v2.g13889.t1"/>
        <property type="gene ID" value="PSU_v2.g13889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13889.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12113" checksum="2A48B78314D5E922" modified="2023-02-22" version="1">MAQDDAAPVIELEKGIRDGVKADLRLDWWTRMLGHVHRISEEQKRAIVSRWPDPFIFMNDLIRKEPDEAIKSIADIVAGNNRRIGPAIAKTLYTFLTSKDGGDVIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y410</accession>
    <name>A0A914Y410_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y410"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14932.t1">
        <property type="protein sequence ID" value="PSU_v2.g14932.t1"/>
        <property type="gene ID" value="PSU_v2.g14932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07385">
        <property type="entry name" value="MPP_YkuE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="196"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14932.t1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48611" checksum="CC8FB6C49AB21D3C" modified="2023-02-22" version="1">MPRRLILILILVDICFLVARFSFEHNGFPHLARIFLILFIELIMTIGSVFLFKRIVSIPSKNNKNHQSTWPKSARTALKIFAFTWILLAHACWIFFYLPLPEDLFFAVICFLAIGAYIHCAVFLFTFFFIERFAHLLLPLSRNPLLISETLHTSIAVILALILTVQGFISTYRPPIVKNLNVFIRDLPEELDGFSLALVTDIHIGPSVGKSRVSEIVQAINQIQPDVVGIAGDLVDGYVDYLRPRAKPLADIRSRFGAFVALGNHEFFHENVDNWIKFFKDELNLTTLVNSAVILEKGGKQLCFAGVDDLYTETINVEGHTLDPVKALESCPQNATTIVMSHQPNGASRILSSIQNTNKRVDLILSGHTHAGQMYVVYPLSFFSNTFFYGLYSHPSSGAQVYVSSGVNYWGPPIKMLPSLCEVVNVKLHTAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4S0</accession>
    <name>A0A914Y4S0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4S0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14230.t1">
        <property type="protein sequence ID" value="PSU_v2.g14230.t1"/>
        <property type="gene ID" value="PSU_v2.g14230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043843">
        <property type="term" value="F:ADP-specific glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF0">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14230.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9783" checksum="F05F4249D1959D2B" modified="2023-02-22" version="1">MRLEKLRLIKRSMLQINPLMPIHVELGSMSDPTFVNEVLYRIIPFADSLALNEQELTFLSKIGNGPYTEQYPVRSGALHVHKVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y574</accession>
    <name>A0A914Y574_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y574"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14388.t1">
        <property type="protein sequence ID" value="PSU_v2.g14388.t1"/>
        <property type="gene ID" value="PSU_v2.g14388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14388.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="25663" checksum="6FA6D21E696E7A97" modified="2023-02-22" version="1">MNHKGILAEALRHQTPPDYLVDLPGAVPRPPPRLPPLPSINPMDPSTSRASHYSPEELEFRKRCGILSLGLAQQAKSFPPHDSTAGFKNSKTSSSPPRKSAKPPLERSQQYVIDSSDDESRGGMLGALLSGRKRARTLSRDGTKKKAKTNKRRMSQGDITPDEQQPYDYGSGILGTALQRFSTRESLADSKGVPQKDGATTSGKPSPSISRSTSMALAHHPANLSSVTGDGKTVTPKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y590</accession>
    <name>A0A914Y590_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y590"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12862.t1">
        <property type="protein sequence ID" value="PSU_v2.g12862.t1"/>
        <property type="gene ID" value="PSU_v2.g12862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12862.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21749" checksum="AF3C79F4BEB0D879" modified="2023-02-22" version="1">MESNLQPPGPTRRTISHIQTRHNSERDLSDVDPEEDEGSNNLGGNNAGPSSHTIHGNESSNFRVSMRTSRGLAGLLQQASAAQAAAAASAASNNRTNNERRTLLRLLAGRDVECPVCHKRVPSDDVEVHLVMCFTRPKLVYNEEILTTDRGECSICLDDMEIGNTVARLECLCLFHKGCLDEWFKRKNVCPQHPGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5C4</accession>
    <name>A0A914Y5C4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y5C4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13976.t1">
        <property type="protein sequence ID" value="PSU_v2.g13976.t1"/>
        <property type="gene ID" value="PSU_v2.g13976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="94"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="304"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13976.t1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49735" checksum="93203BD9A3216DAA" modified="2023-02-22" version="1">MLQKVISEEEQERTPYKYVPQARNVDVLFYEDQKSAGNYADVVDHDDDIVIENFDGPVIRMQKWEEAELETQLLINIKERSKYGRPRKIQAAAIPFILDQFDIKSQGETGSGKTGAFLIPIIDCCMKAKKATNEDRFESEAAAPYAVIIAPTRELVMQVYEQAVKFAADTGINIAKCYGKYDIGINHREICDGCDLLVATPGRLKQFITVGEVRVKKLKFLVLDEADRLLDSDFLDDIKNIVGVAGFPDKEKRQTLLFSATFPAHVMSAADEILKPCAVFITNRRNNPNKRIKQDFVIVENQGKLDKLCEILKSEAEKVGGTDKMRRTLVFVNTKRMSDLAALFLCQRGIPATSINGDRGQHLREQALSEFRSHKVAVLCATDVCARGIDVKELDHVINMDFPADADTYIHRIGRTGRIAQGYSTTFIEEFGEMVKQFLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y693</accession>
    <name>A0A914Y693_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y693"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14969.t1">
        <property type="protein sequence ID" value="PSU_v2.g14969.t1"/>
        <property type="gene ID" value="PSU_v2.g14969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14969.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16228" checksum="A9334D3D0A6DC853" modified="2023-02-22" version="1">MAETKEKTYWTALESNPDTMNKLIKDIGVKGLRCEDIFGFDEDALAFVPQPCYAVILCFPDYVKAYDYVKKSYEELKAKDYKNPDKVFFMNQKIGNACGTFSLLHSIANVRDIINIGKHFAPIIAILMNFLYRKWSICSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7C5</accession>
    <name>A0A914Y7C5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7C5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14647.t1">
        <property type="protein sequence ID" value="PSU_v2.g14647.t1"/>
        <property type="gene ID" value="PSU_v2.g14647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14647.t1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43278" checksum="12B4F79C1CDFCF53" modified="2023-02-22" version="1">MPSLNKDILLEILESIVQNNLNESNKLQMEMYKFSLIGKENLSILMEFLEKATECNIDKDCYIAKIRQNTLLISPSSLYLLSMMKKIGQNIESLTIQGEPDNTKPIIDAICEVKKLKELDLEDSLGIFAFHRVIKECSTSLKKITACVNADIPEIGAVDGLHLDELLIETDLNNNFNTFLNENSCKTNSLSFDLYQFLPTSSFNWDHLIHSFSGVKNPVLNHVKEFKLLLEIDEYAEAIQLTEFIKNIAETFPNIELFHFEKNIPTQLYYGTNPLKYYNAWYDQFTATTHHFKTKILWNISQKCQSLEVTKQNILSQTPKFKVIKEDDRQITLLCCEQLSNLKDLTFQIHLTSTSSSSRTNENSILAEMNSFNGVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7K9</accession>
    <name>A0A914Y7K9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7K9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14733.t1">
        <property type="protein sequence ID" value="PSU_v2.g14733.t1"/>
        <property type="gene ID" value="PSU_v2.g14733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14733.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="27275" checksum="D72466FE7CE4DB3F" modified="2023-02-22" version="1">MDQQILYKFQMKRFEVFKAQDSENDHFDVIFEINGKKLYANTFMLCPISTTFKSMLSDRWTKRDETIPIQDYTFDDFKEFLTFIYSGKCALTNENVFALIDMAEFYGVPEFKEACEKFSLNIIDTDNALKIHEYAFKYSMAQLKKSINIFIAKNLSNLINSEKLQTLQKSAVKDIIESINKMSKQEELFEIIFNWAQIQATEKQKLEPNLNLNEAIKEELIDFLPFIKYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7U1</accession>
    <name>A0A914Y7U1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7U1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13671.t1">
        <property type="protein sequence ID" value="PSU_v2.g13671.t1"/>
        <property type="gene ID" value="PSU_v2.g13671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13671.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36649" checksum="C6AED33F45443822" modified="2023-02-22" version="1">MLKCGAPIESVLAGIQRNSSEPGSDWLLAEPRSSNSESSSELTCYAPEGGNPSERHFEAFPNNGHLKLMERFEAASANAKTYRMVFRPNGITVTMDTRETIKIACGALATFLLCGQAANNLVLVFATPRFDVINVDCDIWTTFTRNTSSVFVSGTLHPEELRRFIETHKHPSTVNILNQRFLRSGSLVDFCRLIPPNVTTFVYDSRCTSNSYLIENVMALYGDLFLRKRNSSLASKSSSSSLLISRLAEMLKDDAPAYAAVLTMMPGDDVILQTLLGHNFKRARPGYLCNMDRCYEKFDYWRSSVNNKTIIFGFLDPNVGPVPEANGAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y897</accession>
    <name>A0A914Y897_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y897"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13819.t1">
        <property type="protein sequence ID" value="PSU_v2.g13819.t1"/>
        <property type="gene ID" value="PSU_v2.g13819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037203795" evidence="1">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13819.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16785" checksum="2DCFCB6BD00CB2AD" modified="2023-02-22" version="1">MHFSVVVTCFILFPVIISAAPSPQLQDKAKRESTPMGNLIDTNAYRMSFGKRTVDPNAFRMSFGKRTPPMDPNAFRMSFGKRLPSPYANNNNGLYAKRDMEEAPEEPIMDNYELENNALYETPLIDHDSFNVDKKMDRNSYFVGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8F7</accession>
    <name>A0A914Y8F7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8F7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15558.t1">
        <property type="protein sequence ID" value="PSU_v2.g15558.t1"/>
        <property type="gene ID" value="PSU_v2.g15558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15558.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18797" checksum="5629036734C5D46E" modified="2023-02-22" version="1">MARFKKIVHLVAITEQNLIVIHQFFAFDQYCLSDDLIEYQDQSGNLTFSNVGKCSLVKNECEHWLLICKTDLCNIRCQEESSESSSTSISSGPSTTVTVQQPSSTVPPSISRLTSSIPSTSTTTSTSTSTSATTTTEVKKWWNLFNYFILSFWILCFDLPFYALKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8M3</accession>
    <name>A0A914Y8M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8M3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13935.t1">
        <property type="protein sequence ID" value="PSU_v2.g13935.t1"/>
        <property type="gene ID" value="PSU_v2.g13935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13935.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12055" checksum="A02A4AF026714D02" modified="2023-02-22" version="1">MKPVSIGRHCLVISTSILLLVAVSFSIAAIATPSWQTVYLAEFQSEHEHGLWMDCTITRRYSQGFINYHQHCTYKFENAYFPDGGGVHQEEEQHKFHGKFKFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA53</accession>
    <name>A0A914YA53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15644.t1">
        <property type="protein sequence ID" value="PSU_v2.g15644.t1"/>
        <property type="gene ID" value="PSU_v2.g15644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34311:SF10">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34311">
        <property type="entry name" value="PROTEIN CBG21698-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037826464" evidence="1">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15644.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25977" checksum="382B5ED7D5B45DA6" modified="2023-02-22" version="1">MSRIILAAFIVIVAYASSASAQNDPFACNTTLFDQCMTTFSTSLNLTSSRPYDNPQQFRYQIEQYYQRGSFNGFFSFCRIFRAFKTCLGPEYINCMNVAHFAVNGKASLQGAYDFVSVFSQQHFTCGAGFDIYVRNEDCISSTWANHRFHIAQCYQAYYQLIDGQSQAGCTAGRILSECFESEFAENCSSARTDVVWWGCEYGRTLMITQFPQCDRMCTSKQKNILKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBT0</accession>
    <name>A0A914YBT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the globin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBT0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14935.t1">
        <property type="protein sequence ID" value="PSU_v2.g14935.t1"/>
        <property type="gene ID" value="PSU_v2.g14935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053341">
        <property type="entry name" value="Oxidative_stress_globin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47768">
        <property type="entry name" value="GLOBIN RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47768:SF2">
        <property type="entry name" value="GLOBIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="2">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14935.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17963" checksum="4D2FC5DAADF75C65" modified="2023-02-22" version="1">MTFTRSLDFIINNLEDMKKIRQFCRRLGKSHVNYIERGFKPEYWDIFAEALTECAIDWEGGVRCRDILIGWRTLINFVIEEMRISFVKERRARSSSVCVTDSPNDSASSTTFHSTDLLHSKEWDSGLLPLHFDDRPENRRRATSLQPSQRCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC01</accession>
    <name>A0A914YC01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16287.t1">
        <property type="protein sequence ID" value="PSU_v2.g16287.t1"/>
        <property type="gene ID" value="PSU_v2.g16287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16287.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15349" checksum="BE6C5605398694B6" modified="2023-02-22" version="1">MDNLKAQIPAHEEFIEKCEKEIEDYQELTQDYQVVAKRTVELKNEPIVVRNIEACVPIIAKNVLDNFIKQKLAIEEPNTEFEEELIILTQRHEKLSRENSSLVPEISRLLEEFDNEIEVCNKKLEKLEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCF3</accession>
    <name>A0A914YCF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase RBBP6</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCF3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1710.t1">
        <property type="protein sequence ID" value="PSU_v2.g1710.t1"/>
        <property type="gene ID" value="PSU_v2.g1710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="709"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="815"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1710.t1"/>
        </source>
    </evidence>
    <sequence length="849" mass="98125" checksum="B04527C215BBFCC3" modified="2023-02-22" version="1">MSSSIHYKFRTTNVSKTLGFDGQAIKVPELKKAICAAENIKAELFDLMFFNSFNKQPYTGDDEIPRNSSVTVQRVPIENGAKIPKISNPEIAATTKPTPGVPDSAAHIKQEDFSKMTEEERIKHITIQSTFKYTTNNYNRKPMANNMQQAPPDYLCNRCNQLGHFPKACPLLNIRKTTGIPNEELMETTADDPQAMLHPSGKFMIPIMHYKAREQRKLMEEQKKKGVPNSQEQKYKIVKKELPPDLKCPICNDIYKEALVTGCCGESFCADCIQQVMSDAIAADLNSECPNCKAPIGASALFPNNSLRESVEKYKKSLAAPNSATDTVESEEDEHPTKNEPEPLSSPEKTPKLEEEEKSPERVVEVIPPPPIVETEKPVVLPTVNLSAMLAASQKSKQPSLPPPEPVADFSQPPPTMLSQPPPSIPPVVVPVVDFSKPPPNFKLPDLSQPPPFIPSSVPKVNKEVILPKPPQSYNIPHSKPKISESKYDEKDEEEINSVWEKLNVGDDNLDLATLFETRTSYVKQKDDESDAKEKQKRTKLRSKSRERHRREDRRSRSRSPHKKRKESRDREKPSRKRSKEPEYRHKSVEKRSSDYRRKDKERENGNGNGKEKERKVDKEKERKEEKRKSDEQKESAIRDRRHENDNDRKMVKYGDEEKNVVKNETEIKKVKEKVPVQKYPSESPTKKEIIADYEDLKKASSSSQETIARVEVKEREKEKKKDTVKEKELERSKDNGKEREKEKKKDKERDHREKLEKKKSNKKDKTLDTVEREKDKEKKKASSKEKKKVKSEEKKKKKRRKSSDRSDEEEEKQKKKRHKEKKHKKDRKRERESMGDESEDDRRKRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDK3</accession>
    <name>A0A914YDK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDK3"/>
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        <property type="protein sequence ID" value="PSU_v2.g18301.t1"/>
        <property type="gene ID" value="PSU_v2.g18301"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037942818" evidence="1">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18301.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23198" checksum="928BC9DA453CDBB3" modified="2023-02-22" version="1">MFIMGILILGGSVGAKVSLRDSDFDYSTPNPLGRMADRRQSMYNAFTGDYDIKSCWGSKNAQANIPMLHVTGIDRRSRYSCSIDFSSTTHIGPLALELSGLPLKERIIIIAAKLFFKKLHLIYRNRLTSSSFAVAYLCFRKDVNTLERSFGKFMAYYAGFDFHRYRMTSNGPKLKPLPGATYEAYDIHALNAANPVPGIINLIVAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEB0</accession>
    <name>A0A914YEB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEB0"/>
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        <property type="protein sequence ID" value="PSU_v2.g17780.t1"/>
        <property type="gene ID" value="PSU_v2.g17780"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF151">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17780.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19411" checksum="B0829B52BC6C37C1" modified="2023-02-22" version="1">MLTAIVPPTDGIAVVNAVNIEDKPPFGFVPQKDAVLGDLTIYETLMLFARLNGIVDTVEVVECLMECLQIAHKKDNLAKNCSGGELRRLSLAVALITNSDVIMLDEPTAGVDPRTRRNVWELLIALRAAGTSQILTSHSMEECEALCTRIGFINKGELVGIGTSQHLKHRYEFCVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFS1</accession>
    <name>A0A914YFS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19147.t1">
        <property type="protein sequence ID" value="PSU_v2.g19147.t1"/>
        <property type="gene ID" value="PSU_v2.g19147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF252">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19147.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23947" checksum="2F28927ECF79B4D6" modified="2023-02-22" version="1">MIVTAMIGCCGVAQGSRIFLGCYASAMFVLLIFTISCGVYILFRQNGIDVELSDALNYMVQHYYQGAGIVQEALDRLQQAFRCCGNAGCSDFRIFRQDPPRTCDIRCDGCHYRIKLALQIGFSVAVVVYGICMLAEVVAIAVALVLAFRGNPKYYSRSIYLYPTPTQQQYERQKIDRQLQSEHSTLQRSRSQGWQQRQRQYLGPPRYQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG66</accession>
    <name>A0A914YG66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18438.t1">
        <property type="protein sequence ID" value="PSU_v2.g18438.t1"/>
        <property type="gene ID" value="PSU_v2.g18438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18438.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14057" checksum="1BD2A4FAC193D79A" modified="2023-02-22" version="1">MSLSPPPSYDTCQAPPLPTNSNLQNLSYENQNSQNGSGGNGERKGGPPSTPPAPNPMILPPSVPPGGVEGPPMIPPYPPAAAPPYYNYNVGYYTPMNGVNGGGPLGGIPGEPPFCQGLRAGNGRMTPQGGRYYGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI51</accession>
    <name>A0A914YI51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI51"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17.t1">
        <property type="protein sequence ID" value="PSU_v2.g17.t1"/>
        <property type="gene ID" value="PSU_v2.g17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17.t1"/>
        </source>
    </evidence>
    <sequence length="454" mass="52781" checksum="23B7F699BDC97301" modified="2023-02-22" version="1">MPSSFYNTTTLNHPFSGSRGKELFEELGKDYIALQFYWDDYGTSNPLHTSTASLYKMTGCYFRILNLPLALQSTYEHIFLAFLAYAKDLDENLQYALSQTVILQLKKLEREGITLLVNEQEHHFPVVLFNVVADNLGLHQVFGYKRYFAGGKVCRMCLIPYDQIKVTTRIPPNMLRTASSYDNILQNGDAETIRIAGLREQSALNKLIFFHVQENPSVDMMHDLPQGHLRHLAALVLNELPNYDRVYQAIRTFPFHGKDAFNIPRPAQREQLKDELKGMTANAMLTFIRFLPLILRNIQIPRVNTSWGLLLKMEEILDILLGYHFTEEILQDLQRKIEEYLRIYIQRRGKEIIFLLQWKNVSKDFKKNDIVVFAQEGREPTFGRIEKQDDDGNYTLSKLRTINFVSNLHCYKVAETGQFVLCRAPAFLIFDGMRLYHGSFIRLPYSLFCESFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK99</accession>
    <name>A0A914YK99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19763.t1">
        <property type="protein sequence ID" value="PSU_v2.g19763.t1"/>
        <property type="gene ID" value="PSU_v2.g19763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19763.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58965" checksum="D2A7452EA93C2FD6" modified="2023-02-22" version="1">MSSTNRNIIIKGEHSLILGKVHWMNIDSRKHDSKTFFLPKRNAQEYIEQLFEESGVERKDVKAIAFIHNEHEMETWKKAYEFRKGCYDFCQKNGIFFLHSTSFGYHYFVATLRSKAVGNEGDQLTVIYCEMNAVLGQSFVRESGRWKCNFVHVAVEFENTQEWKHQFLRGYEPKKIVFMHHLDGFDFQEVIDLFNIENSVVLKGGYEYLSTGSIDKILHVMGEKPIPYDIAPQCVYVYAVNLGKDNLICVNYENVLPFEKSGIIDVNPCKTLTFGAKLAVFKPFEVIQEIELSTFKCKKLKVTLKIDVNCFYHFEVEPIDDKDLCGQFEELEILKAVEKPPFSPRKAQIIFNKHECWLHFTCDNGCTHPTPDIDGLDKTPIYIAFTEEMPLVGKAAKEVYRCKPEYVVFDIIKLCSIKSSDTANPNWGFTISKEEESLMVTLQTLDGERKSSVEFLLALIIKNALKPHVLGGSKPPKWDKAEIRFEEFIPNETLKQAFLSAGKLLKMKIDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKD4</accession>
    <name>A0A914YKD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tail specific protease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKD4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19986.t1">
        <property type="protein sequence ID" value="PSU_v2.g19986.t1"/>
        <property type="gene ID" value="PSU_v2.g19986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000090">
        <property type="entry name" value="Tail-specific protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020992">
        <property type="entry name" value="Tail_Prtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32060:SF22">
        <property type="entry name" value="CARBOXYL-TERMINAL-PROCESSING PEPTIDASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32060">
        <property type="entry name" value="TAIL-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11818">
        <property type="entry name" value="DUF3340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Tail specific protease" evidence="5">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19986.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="38693" checksum="43FB00861D7B6C1D" modified="2023-02-22" version="1">MTIPAANGEPARKIGVIKLPTFYQDFEGRRRNAADYASATRDVAKLLAGFKNDKLDGVVLDLRNNGGGSLDEAIELTGLFIEQGPVVQVRESGGRVTVNSDRNQGVAWDGPLAVLINRGSASASEIFAGAIQDYGRGLVIGETSFGKGTVQNIVDLDRWPSGETQRFGRVKLTIAHVDATEFGESTYDNALPWTRIAAVPHTQYGNFAPLLPKLETRHDARIATDKEFQWWNEDVQQFRTEAAKKYISLNEATRRAERERQDTQRKERQVQRKELGLALDPLADDSSDDGLTGNERDIVKDAAREKAAEKRPDPLLRESASILADAVNLLANDRPLSAQVLPQSTGAGRWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKI4</accession>
    <name>A0A914YKI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19390.t1">
        <property type="protein sequence ID" value="PSU_v2.g19390.t1"/>
        <property type="gene ID" value="PSU_v2.g19390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19390.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33783" checksum="7C2AF759B16A99C9" modified="2023-02-22" version="1">MSIKEKLNIVPIFDKDVDLDSDGIDETFDEYCFDITINAKKLDENKYVIILKVSPQEGSKYELIVDYLLMINQRCFSRERDYWKKKEVLESVIVTESKVRICFGICVQQALIAENLTEKTSFRYYRILCAGTTFFINPTYLKNLECELFTKWYNDEVTHESCTIIQELSENELEILLNACCGYSSIVIHSRNIYEVGEIAIQLRIVGVIRAIDAYIRSLKLMHPVRKLEMALFFRLTQVADEIIRENKNSMSRLTLLHEYLDENDEDICDMHPDVLKMLEIFDDYIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL17</accession>
    <name>A0A914YL17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 7 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL17"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18015.t1">
        <property type="protein sequence ID" value="PSU_v2.g18015.t1"/>
        <property type="gene ID" value="PSU_v2.g18015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045819">
        <property type="entry name" value="TTC7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19440">
        <property type="entry name" value="TTC7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 7 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18015.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41575" checksum="64741D7B6B4EE5D9" modified="2023-02-22" version="1">MATKLKGSKLEAEVDKCRGECNWEKLNHLITNIRTRNSGAEKLIHLVDGELSLEVFLQKHAGLQDRIEPRAQHKDFLRRAEGQLRNAITNNPGEATIVMEAYLLLAKLYYFCASFNEALSSIEKSQMDKATTQFTTLRSLKLAAEGYAVKGLAIEHTLPKDRKENDVLYKRVVSSFEKSAELALSYISELEKSVNSSSSTSTIPSPNIRIGGLLEIALERVSYLSLRRNTSDRRWDLEGLEWYRKIAIALSDKLVVMKLHQRLCRQLAEVLLRGMIDVGYDSAAIYSKSESLKFYTGSRNYFAPASRSEETILLLLISELLASKNIRTSNTTDDEILDRVQLIRNLKKFIIYYQLFYLIYANIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLA3</accession>
    <name>A0A914YLA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19673.t1">
        <property type="protein sequence ID" value="PSU_v2.g19673.t1"/>
        <property type="gene ID" value="PSU_v2.g19673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027967">
        <property type="entry name" value="DUF4612"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15389">
        <property type="entry name" value="DUF4612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19673.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13287" checksum="8308E5ACB5C2FC28" modified="2023-02-22" version="1">MGCRMSRTISQPDLASPSGSTDRKGIKDNNNSMTSGSFPLLSNSKESPRMTQGRMTNGQSILTRRDTPGGSLLDIYANRNGSGNSTDSATSKVPESASQADFFRMLDEKIAQGAHNLPESDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM13</accession>
    <name>A0A914YM13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM13"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18359.t1">
        <property type="protein sequence ID" value="PSU_v2.g18359.t1"/>
        <property type="gene ID" value="PSU_v2.g18359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18359.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18998" checksum="603AEC66455A1A03" modified="2023-02-22" version="1">MSSTYLCEALTQAFVTGLLNQETHQQLAERKGLHVVEMKASRQYFPEVIASPILTPLKSEEDLLPIERLKLDDFYGEGRYPLFKEKPPPFYSKLAGHLDAEWRKWPFRNQEKVSIRLLADGVVPRWTRTQRHEWAKRQQELFENGILQIPKGIGLSHVVDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM73</accession>
    <name>A0A914YM73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20679.t1">
        <property type="protein sequence ID" value="PSU_v2.g20679.t1"/>
        <property type="gene ID" value="PSU_v2.g20679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20679.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10518" checksum="A09F8910208D8A2B" modified="2023-02-22" version="1">MTPYNTDLGPEFKLKIHCQLNETHLEFIMNNCCVAFEDDQLCPDTPDEFVALISATQNEITSEADYEMHVATVTPVQDQLRNLLKTLENDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM91</accession>
    <name>A0A914YM91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM91"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20040.t1">
        <property type="protein sequence ID" value="PSU_v2.g20040.t1"/>
        <property type="gene ID" value="PSU_v2.g20040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20040.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10309" checksum="03F0B701D43AFD62" modified="2023-02-22" version="1">MKKFIKVLLGRKQHPNCRKVEFVYDDDGSPTISDVKDAARAQLLISLDNCDVKTRIEDNTVATLADDELYDPDDNIWIDATGSQFSVHRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNG5</accession>
    <name>A0A914YNG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNG5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2409.t1">
        <property type="protein sequence ID" value="PSU_v2.g2409.t1"/>
        <property type="gene ID" value="PSU_v2.g2409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581:SF3">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581">
        <property type="entry name" value="PROTEIN CBG10435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2409.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12133" checksum="CCB4797EDD779F02" modified="2023-02-22" version="1">MLLPNVEFFQQNAKSMTPEWSDKFDMVMIFDACHDQCRPDLAIKEIYRVLKPGGIFAMVEIDGTSNVSEDKNTFGPAACAFYSASVFHCLAVGSNSEDKVFIISWHGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNJ2</accession>
    <name>A0A914YNJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene desaturase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNJ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2432.t1">
        <property type="protein sequence ID" value="PSU_v2.g2432.t1"/>
        <property type="gene ID" value="PSU_v2.g2432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2432.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8624" checksum="17FC8AA3770FC95D" modified="2023-02-22" version="1">MVFPTYINKMSEFYVEEIARAEKPELSRIPCFFISAYSLRDLINGEEPEAVYQEEAFLDYIKTKSKYSRNIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNN0</accession>
    <name>A0A914YNN0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YNN0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21023.t1">
        <property type="protein sequence ID" value="PSU_v2.g21023.t1"/>
        <property type="gene ID" value="PSU_v2.g21023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21023.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8717" checksum="F4D2700DEADEC88C" modified="2023-02-22" version="1">MGMYYPSREGYRTIDNYITVPIGKLIKRQNVDDLLLDYNEYIVYSTEQIKIRYLVQVNIGKKGVTRKNGLIGGSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNZ9</accession>
    <name>A0A914YNZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2070.t1">
        <property type="protein sequence ID" value="PSU_v2.g2070.t1"/>
        <property type="gene ID" value="PSU_v2.g2070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF24">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037226383" evidence="5">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2070.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15750" checksum="228397F9B900F03F" modified="2023-02-22" version="1">MNYFVSAFIFGALIDFSIAGLLSRTQSTAVRGSVICGEKITGTVRLELWDKDRTDPDDLMMKPITVSYGDTFTVEGKENELTTIDPELRIIHKCGFEGAKCLKKSIILISDQYVTAGATAQKNFNAGQIDLRNIQSTDTTDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ06</accession>
    <name>A0A914YQ06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ06"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2902.t1">
        <property type="protein sequence ID" value="PSU_v2.g2902.t1"/>
        <property type="gene ID" value="PSU_v2.g2902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2902.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24509" checksum="8616938A047E14F4" modified="2023-02-22" version="1">MIRLNSLFALRILNICLVIWLIFEICDRLKDDKAWKNFWGVKNEELNKAELKWDSVNILEPPSLNDSELEAMRLNEYFAKPQYHCSNRKLVGGPSDNFLLCFDKKKTVVITGLTNSPSVFEAELNTTRWEAYLPPDSPIIDEFKFDVEVQYIPEVVEEDYFPMETIIDGIKDSTFAVAKLEFYSNHFKNDQLEKAPELVEKILDVLLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ13</accession>
    <name>A0A914YQ13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQ13"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21117.t1">
        <property type="protein sequence ID" value="PSU_v2.g21117.t1"/>
        <property type="gene ID" value="PSU_v2.g21117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="253"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="353"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="440"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21117.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58074" checksum="5D8960E30FC25F94" modified="2023-02-22" version="1">MATFSRALNIESFPEPKVETRFCGKCQFSRHCTVLQKLATTKSMAISEEMEKFTNNSTFHLTENELEYSKQWLEWTFMEWKADRKRKNMDGIFMETPKQRESNGTCLSNVILEKFEKKEDGIIWFTFVKQSKEKLPSNVLEMSELVVISTDEIVAVQTGVVIDRQDGYITVKSDKEFSKRLSSSPSLIFHLDQYASNASFPMHLNSIITLLEDSPEAKRLREFIIDLKEPKFGSIQKAQIEKIKPIVKKISVTQAKAVIKALAAKDYLLIQGFPGSGKTSTIVALVQCLVALEKTVLLTAYTNSAVDNMLLRLKEVLPSEMMLRIGGNYSTSRLEEIKPLLLETKLAAFKDRKTMIEQAKNMLMKTPIVATTCLTAGNHNFFTMRTSFDYCIIDEAALALQSSIIKPLLLGNIYVLVGDCRQLEPLVVCKEAKEQGMNISLMEKWEPIAEKGNGIVKLNQQYRMNSKICELSSEMFYDGLLQCATEDVGNQTIEKYDEEMNDGKEELLPRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQA0</accession>
    <name>A0A914YQA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2356.t1">
        <property type="protein sequence ID" value="PSU_v2.g2356.t1"/>
        <property type="gene ID" value="PSU_v2.g2356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF253">
        <property type="entry name" value="KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="292"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2356.t1"/>
        </source>
    </evidence>
    <sequence length="559" mass="62483" checksum="EB5A444D65A5B116" modified="2023-02-22" version="1">MTLSCFLIRRKKSFEEPYALESVSKSPKSGRVHCIPHKWEQKFNGTPSRCIGCTRPIKVFSTCQRCGVCKLRVHSECKSKVGNTCGLTAKHLKACIEHMVHTGNQEDWGRSEDPGSQDLIEAHRPSSGGDIAESSSSNSANSSAPSTPAWPYHGRPGNLTGMSTLHPNFAEMAPRTAPLVHTDSPLSTESLFTFPDSTPRVPSIVLPTSVDGNGNEACHVSDSDTGLRLFGSGDESDQNTLINESFDASFFSGATEDSQGHKWDRKAWSKFTIRDKSSATMKKDLIIPFDKVTVERSIGRGRFGEVFACDHYGEAAVKFLYMNHATDTDNHFEAFLNDVREVKLARHDRILAFFGCTMDRNTNSMGIVVDYCEGKPLHGLLHQRESNARMDFQKVVRLSSQICQGMSYLHNRKILHKDLRSKNIFITSKNNVVISDYSLINIKMLSKPSRKYSIITPDHWLSYLAPELIKSLASDFRALPFSEQSDVYAFGHSPDSIIWQVGYGIKPPIGNLNVCREAKQILGKCWTHDPESRPLFSDISKMVEKLPMKHLCRSPSNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS31</accession>
    <name>A0A914YS31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS31"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2981.t1">
        <property type="protein sequence ID" value="PSU_v2.g2981.t1"/>
        <property type="gene ID" value="PSU_v2.g2981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2981.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13838" checksum="9570A26B54B7B4E4" modified="2023-02-22" version="1">MLSSTALPSLITTSTSFMSTFDLLSTTPIPLTSLFPNEMASITTFSSNFSSTISPVTTFPAVHPYIAYARKIYIWLVPVMVSVLTIAVIGNGLIVISAPWLSRPINPYHRLCVSLAAADTWAASLLVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT06</accession>
    <name>A0A914YT06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT06"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3131.t1">
        <property type="protein sequence ID" value="PSU_v2.g3131.t1"/>
        <property type="gene ID" value="PSU_v2.g3131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3131.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11377" checksum="831DF28E872AF851" modified="2023-02-22" version="1">MEGNGQQHVVVHKRSIDDNLMSATEKMIDSQGAYVTDKLGEDRTENGTKSKRHVKLDGGKIYYGRSEVLINNRIIKVTQQQIGNGQQIIVINKVKRGTKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTN5</accession>
    <name>A0A914YTN5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4040.t1">
        <property type="protein sequence ID" value="PSU_v2.g4040.t1"/>
        <property type="gene ID" value="PSU_v2.g4040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4040.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13192" checksum="C4CDD86481C5BC88" modified="2023-02-22" version="1">MTVKRRNHGRNKKGRGHVKPIRCTNCGRCTPKDKAIKKFVVRNIVEAAALRDITDASVYDQYTLPKFYHKLHYCVSCAIHSKIVRNRSREARKDRNPPPRFGRPQAARPAGAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTR2</accession>
    <name>A0A914YTR2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g3544.t1">
        <property type="protein sequence ID" value="PSU_v2.g3544.t1"/>
        <property type="gene ID" value="PSU_v2.g3544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3544.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48536" checksum="1AF6D6013210C523" modified="2023-02-22" version="1">MYLGVTDSENDTIVDNTWKAKDMKLSEDAKNIIVIFTIDTNGIYEIEFTEAMPENFLTTDDFLQAYCSTANSKCFQTKDISIVDEVEEKYIIPKDIFKNDESIDAVGIDLGTTRCCVAVNRRNGIQTAPLDNTGERLLPSFVAYDEENVKCGQVVVDRLRNFANSTAFDVKRLIGKTLEDIKLDNSWGFEIIAVNNKPKIQVQGPVRQILKHPEEISAALLKQIKRKTEEFQGKPLTEAVITVPASFDKAQKDSTLGAALITGWTKVHLLPEPIAAAFAYFINRPIPDNSTVLLFDLGGGTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLGGGTLDICIFKIVKRQIEIIGRNGDSNLGGRDFDNILVDFFKRELKKRFNIEVPENKKCKLMLRCQEIKHTLTVVNEDRYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU38</accession>
    <name>A0A914YU38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU38"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4167.t1">
        <property type="protein sequence ID" value="PSU_v2.g4167.t1"/>
        <property type="gene ID" value="PSU_v2.g4167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4167.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52577" checksum="EC530A2C9EF05BEC" modified="2023-02-22" version="1">MAFRRSLPKTVEYLEKKMGAIVLNGYNIVGDGTPQAYIPILTGKIETELPLTRKRYKNANFVDIYPFIWKNFSDNGYVTMYGEDCANIGTFTYRLKGFKDQPTDHYARTFFLLSEKHFPTYQCFGSETQFTAWIRYCKEFMEKYPKETPKFSVMHHSALSHDDISLVKVVDDDLKAHFEELFEGGYLDNSVVFVGADHGHRFSVLRETQQGQMEERLPFMSVFLPESFKSKPEGQKVYQNLKANADRLTSPFDIHETFLDILSLSDDLDTVQSAANRGLSLFRPIPETRTCDQAGIEAHWCTCLQWQKANASVATELATAVIQTINSYTEDERKLCAPLRLQTVVDSKELVPDEKVMKYGGIKDKDGFVPKFSGNATVTYATYMITFTTLPGNAKYEATVQYDSKAQEVTVDMLTISHVNKYGDAPHCIIDKNYFLATYCVCYDKIGVNVYKQSIFLKRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUP6</accession>
    <name>A0A914YUP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pseudouridine synthase II N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUP6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3395.t1">
        <property type="protein sequence ID" value="PSU_v2.g3395.t1"/>
        <property type="gene ID" value="PSU_v2.g3395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039048">
        <property type="entry name" value="Trub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13195">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13195:SF0">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3395.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35311" checksum="F28AEFFD133BBB38" modified="2023-02-22" version="1">MKVALTSKDIWQLLNGVLCVYKPRDISLTSIKKRIVNRIVEEGNTYDDSMNSIPLIEMPIVEPHPETEALMVVGTRQQLDYRRHPLMAGKAFRAEDIMIEQITELEPASSGICAFAIGSECYRLDDLRHQAWINTYRMIGKFGEQIDKHYIRGKVVDKAPYEHVTRHKLQKLLTRLRAQYKRASFELAEVDIKSQAAFELARKGVPRPRILDTPVVYNASVNNFNSPYFGLTIQVTGETDYFLRAFIHELGCSLGTIACTKQLRRIRMDVLGKDHALLDKELNVVNIIRNILLCNNALDLAKKERKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUR4</accession>
    <name>A0A914YUR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21221.t1">
        <property type="protein sequence ID" value="PSU_v2.g21221.t1"/>
        <property type="gene ID" value="PSU_v2.g21221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21221.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26762" checksum="DBA1DBB3E26A61D5" modified="2023-02-22" version="1">MNNKKLLPRKYSDGNSEIFEEDGNNFHPGLPNGITTMSRETYYQMMQFALAIQQDCTIAPSIKGLILMMWTFIRHTAFPQLINPRELERQRSIVVSGIPEFLGKPSISCKADRQAAKNILDTLRIQCPIITAYRLGPKRRDKTRPLKVVLPSSGHHKDVLGRAAKLREIPDYENVFIRPALTQRQLKSDSKQRDICRFLNQRGHNVVVYSNVICTRTDPPIPVNLSKFSELAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVQ9</accession>
    <name>A0A914YVQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVQ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3739.t1">
        <property type="protein sequence ID" value="PSU_v2.g3739.t1"/>
        <property type="gene ID" value="PSU_v2.g3739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF102">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3739.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23802" checksum="01B9072E17C818B0" modified="2023-02-22" version="1">MAVPGPTSFENLRTVDGTLYDSNREACVALGLVLNDKLYEDTLFEALNHTSPNQFRYLFARLLAHCDLGNPLELFDQFENHLISDLLKKWQKDDAKKVAWRKIVKSMLNQDKQLSDYPQLEAYMQEIGFENEDTVDLKVLLAEGMADYAIMNKEQKAIVDPIIEKIKSTPQKLEKCCIFADGPGGCGKSYVFNALRKIALGYGKKVMNMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWL4</accession>
    <name>A0A914YWL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g494.t1">
        <property type="protein sequence ID" value="PSU_v2.g494.t1"/>
        <property type="gene ID" value="PSU_v2.g494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g494.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="8984" checksum="4FA32994CE1F59BE" modified="2023-02-22" version="1">MNSSRPVGASSNIIINNDIQNRGAPESSLTCSVCIEEYSVNDGVSCFSRDNVPIHMFCATCVGTYANNEEAMVAYDGSGLVVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXD3</accession>
    <name>A0A914YXD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXD3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4766.t1">
        <property type="protein sequence ID" value="PSU_v2.g4766.t1"/>
        <property type="gene ID" value="PSU_v2.g4766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4766.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7849" checksum="4E063A90960E440F" modified="2023-02-22" version="1">MQKEMIYKAVFVQKTYLSLTGKTIVCFGENLEFTVGIQKKVCETFCVENIKGDLEITKITSTGKFFKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYB4</accession>
    <name>A0A914YYB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4627.t1">
        <property type="protein sequence ID" value="PSU_v2.g4627.t1"/>
        <property type="gene ID" value="PSU_v2.g4627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4627.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="31020" checksum="6A01C4C0DFF3BC25" modified="2023-02-22" version="1">MRFKIKDGFEMGVFCRRDLLFLKRFQRFYKKSQKKIKFYKQNPISQNYKYRNLLLMQKALNAFKSHIYKINSKLTSVTILIGLNKETARMKYLEYKSERVRQKISTAKQSAVHFATLLEQGKKDLEKINTAVQNFSLFGIPGFKAGFLVGYSMISLFPVTINETLTICFAAFATTRITDCTLSFLQSYSEKQWNQIEETANAWQIAVSEFQELLVQTQKYHRKSCKRYKILEKRLKESIQHRRYLEKMIKLTKSLQNKLSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYJ8</accession>
    <name>A0A914YYJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5578.t1">
        <property type="protein sequence ID" value="PSU_v2.g5578.t1"/>
        <property type="gene ID" value="PSU_v2.g5578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="82"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5578.t1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42659" checksum="D586913CB9B33931" modified="2023-02-22" version="1">MNNSNSVRPIRPRDPRGDPRRISQGIIATPPSVLPQKRKASEDLNSSSSDDSKPKSILRLSLKDPREHQASRTLSERKTSIIEESGTDDIETIISKVALKLQSSSSTSVSIGLLSNFFLNYYRIHQENVMFAWHNAFLELERTSQEIYNTNLQDKILTAFYCINDAFANAYELFDRMAIDFTVFGPSAFFYAGMIGNNETITRLQKVLFIWTERRWFSDQFVKLFCNSMDEGKYFGKLCSKDNAYNEAILWTLPEFIRYFESRIDYIQSHQNKFMDKALQRPIVYEQFNSIYEDIKPLLTADSNTLAKNLTHLNQFSEQVDRLFSELKTFCNEELMLRSVIVSITTFIKFMNKTIKPLNKALLPVLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ79</accession>
    <name>A0A914YZ79_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SEC13 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZ79"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5256.t1">
        <property type="protein sequence ID" value="PSU_v2.g5256.t1"/>
        <property type="gene ID" value="PSU_v2.g5256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5256.t1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34864" checksum="98DBDDF5AB405F0B" modified="2023-02-22" version="1">MVSMQARIETSHRDVVHDAQLNYYGNRLATCSSDRMVKIFEVKSNGQSFPVAELNGHEGPVWQVSWAHPQFENTLATCSHDRRIIVWREINGKWQKVYEYRQHTASVNSVAWAPHAFGMVFACCSTDGSISIVEFKNDVWSPLRIVDAHANGVNAISWAPAKPARSADGKIEYEPMRLVSGGNDHLVKLWKRSDDGSTFEVDTELKQHLDWVRDVAWAPCDLFGYSSIASCGVDRRLVVWKCNDLDKKLWSSQVLHVFDDIIWHVSWSLCATMLAVAGADNKVSLWQERTPNKWTEISSDEDQVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZG2</accession>
    <name>A0A914YZG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 144</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZG2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5486.t1">
        <property type="protein sequence ID" value="PSU_v2.g5486.t1"/>
        <property type="gene ID" value="PSU_v2.g5486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5486.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="39033" checksum="9607E2D66CB6923A" modified="2023-02-22" version="1">MTQISVEGLLQLFTAVILFGSMFVPIKKYNAGDGFFAQWIMSISILLVGFCVFATQSFATFYPMAMLGGVFWCLGNMMAIPIIKRLGMALGILIWNSTNCLFGWAIGTFGGFGIEPRPASIPWLSYSGLSLIFIGGIMFAFVKNKPDPKPLNDKKATYQLYKLSDGDNNEKVPIDDKELAILPMNPETTTSSLSEETTDLISNNSSKIFGIIMALISGALYGINLAPVIYIQDNHNIFIDAPKDGLPYAFSHFFGAFITSTIGFVIYAIVKKNRPEINPSIAIPALIAGLIWAIAMCCLLTATSQLSASISYPISAMLPGCVAACWSILYFKEIEGGKNLILMIVAILVTVSGAVCIGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZV3</accession>
    <name>A0A914YZV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5153.t1">
        <property type="protein sequence ID" value="PSU_v2.g5153.t1"/>
        <property type="gene ID" value="PSU_v2.g5153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF33">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5153.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26140" checksum="A068A948DA1D5AD9" modified="2023-02-22" version="1">MVIGLFAGYGFVIGTFVSMVLFYGYSGQSKYFDAANVYTITDIIQHCLGFVACIFALWRMRLLNFPYHDPHSHDPHHAAHANQELLDMILLAVGLIGELCFSISGLMGLYGTRKWEPFSVALVAAHVARIVQAIVQSFLICIASKLKINQSRKRDHPGKQTITFLIILNIAIFIMNLFESDKVGTSSAVVEFYGTETWVFLVRTFSPLTVFFRFHSSVCLAEIWKNTYASKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZW4</accession>
    <name>A0A914YZW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZW4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6034.t1">
        <property type="protein sequence ID" value="PSU_v2.g6034.t1"/>
        <property type="gene ID" value="PSU_v2.g6034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6034.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32679" checksum="146C27959B1BF7A6" modified="2023-02-22" version="1">MSAVYAIRHREHASITNGCGSVVAELDDDNWVPKRKSPRTGRTVVVECSSPEAVPSTSTAAATTPTSNGSQNSQFQPKKSRNGVIIEEKENDPEPKRYDKLPDLMKATLGHAMRKKGWRIMVVEWGFTFYCSPFSQRCRVLSVAVGDPQDGTATYFPCDLVKSVNDDGLMAIIDRFIIPVGYDLQPHLCILCLNLNDVDGKSYANPTVIRNLIWHMQGIFNHRLLVIVDGKEKDPIGLYVADILYGKDCDKNAPSRPPIRKNDSAIRSVIECYLKNPSPTKDYLRTLIRRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0H1</accession>
    <name>A0A914Z0H1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0H1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5662.t1">
        <property type="protein sequence ID" value="PSU_v2.g5662.t1"/>
        <property type="gene ID" value="PSU_v2.g5662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000355">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF405">
        <property type="entry name" value="PROTEIN CBG12249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5662.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="25624" checksum="7926FA0A0B29F6A5" modified="2023-02-22" version="1">MIASAPVIAVMFATFNHVITTSLMQNYLPTYARDTLDLNLRNNGIFTSIAFICKIASKYVLSFTADYLKSKKIFSPTASCKIFQFIASFGVAFMFCVIAFFIDCTRQHLALIVLCFYGIFAGSAIPGYFTSSCSFAPMYTGMVSSLMEIAGAIGNLLAPALVGIFVKQGQAGEWAYVFMSVAAINIITGTVFLFCGSADIQPWAKPKTTSKKDLEESNIELVNDNIGFRRNDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0L9</accession>
    <name>A0A914Z0L9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0L9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5697.t1">
        <property type="protein sequence ID" value="PSU_v2.g5697.t1"/>
        <property type="gene ID" value="PSU_v2.g5697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5697.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28264" checksum="8AEFE1FB64A5E557" modified="2023-02-22" version="1">MHQVANFSEFEYDGNVGVQIGPHGSFTCICTTDVSAAYGIIGDELFVASFGVKPGEDVEKLHLFSIDLINDSVTDYSRNIIIAADLKDNLCEKCSPSSLVALNKSNTNEIFIVPWTSGFFSTNIGFADYVQTKLLINREKQTCEFLGFFGFKFLGPFYAMNRSLNCSNMGNLEFGKIVYFQGDNLFLCEIDKIQLHIIESDLRAQSSYTFYNCSKGLQCMSFDRQLEEEGEVDTFCCIYDVIIDVERHQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0V5</accession>
    <name>A0A914Z0V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-specific protein-tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6357.t1">
        <property type="protein sequence ID" value="PSU_v2.g6357.t1"/>
        <property type="gene ID" value="PSU_v2.g6357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="308"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6357.t1"/>
        </source>
    </evidence>
    <sequence length="543" mass="62420" checksum="B6C95F3EAE399932" modified="2023-02-22" version="1">MVLRFLMSSSKDHFVVRWDYRATEKRNNSATKFISLKAGTIVRLIKFHRRLNEDGSEKKIQHIAEISVVKNRFQKGFIHIAFLQPLFTFGFPISSAGLEYQKYYGIDERLWDCRWYLAYANPIYVSIKLRSDSSAPFGSFVVIGNSEMDSRMKKHWKNLLLIVKWYSGSLAAFLQEHKRNILHSELYNGTPVTSKDRRPLDDSASNGIAFIPIQRTQTGKFFINQQKVFSSIFSLLSFYFGRRLPLCTGPALTLTQPFQILDKSVRGLPPHCHKKPGTQYKMPPNCSGLFVQNVINKQRFLTSLEIDKESSSLLGKTFYGIVRDGNEAAEIAAVKLLNKYWFDQGSFAADLALLKLSERKNNEALKPHNRNTYYIHGSEYLAKIVAHSHPQKIASPFVAYEFFPNLSIYDSLEYGRKFSYRTILEIMYQVAGAMFHLEINGLCHRSLCANNVIIHWDDEVSVSIKVTDYMLPSHHFVSKIDREGDEKGIKPIKWQWMSPESIFHGIMDIVSDSWSFGCFIFELINEGAIPYSYESPAIKNIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1A3</accession>
    <name>A0A914Z1A3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">26S proteasome regulatory subunit Rpn7 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1A3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6498.t1">
        <property type="protein sequence ID" value="PSU_v2.g6498.t1"/>
        <property type="gene ID" value="PSU_v2.g6498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit Rpn7 N-terminal" evidence="1">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6498.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14514" checksum="7607CB9BBCA65EC2" modified="2023-02-22" version="1">MRNFVQNYYNFIKTEAATISTINNSNVLSKISAVNISEFECDIVFYVECLNPSKSKTSNITAVKDMAKTAADKFISVDHEVFEFPDLLSTCDIAYYGCFCALASYDRNQLKEKVINNGNFRKFMEPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1E0</accession>
    <name>A0A914Z1E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1E0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6175.t1">
        <property type="protein sequence ID" value="PSU_v2.g6175.t1"/>
        <property type="gene ID" value="PSU_v2.g6175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6175.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14372" checksum="C5D097EF4C149BF0" modified="2023-02-22" version="1">MEKENTELYRNYSLLQSQLNQLERENAARATEANNNKKMKLEAEIHKLNQEKRQLEKIIEQREQNYLQKYKMFESQLNILREQLDAERRRRREITAFGATFQTANRRSSGGGGGGGKPPFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Y9</accession>
    <name>A0A914Z1Y9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type II subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Type II protein geranyl-geranyltransferase subunit beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Y9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6376.t1">
        <property type="protein sequence ID" value="PSU_v2.g6376.t1"/>
        <property type="gene ID" value="PSU_v2.g6376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6376.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16871" checksum="2B3060A3396677E0" modified="2023-02-22" version="1">MSLASVWNIARRDVPIPVNSPTELLSEKHATFILKYGKSDNLFEYIMSEHLRVSGLYWCITALDILGKKDESDMDLMLQVINEAKNDDGGYGAAKGHASHILHTLCAVQVLLTLDRMDLIDAESLVQFVKSLQQEDGSFHGTPEGWFFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z277</accession>
    <name>A0A914Z277_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 18">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase ltn1 and nemf. The complex probably also contains tcf25 as well as vcp/p97 and its ubiquitin-binding cofactors. RQC forms a stable complex with 60S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z277"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6814.t1">
        <property type="protein sequence ID" value="PSU_v2.g6814.t1"/>
        <property type="gene ID" value="PSU_v2.g6814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056241">
        <property type="entry name" value="LTN1_HEAT_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24618">
        <property type="entry name" value="LTN1_E3_ligase_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="20">
        <location>
            <begin position="1073"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="1081"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6814.t1"/>
        </source>
    </evidence>
    <sequence length="1133" mass="129736" checksum="284700341B3B0AEC" modified="2023-02-22" version="1">MLDSFFDGTEIGLPLFSWTKAFAEAIKFSFLKAFEKQDSKEFQAFLVEKDKKDTVPIVVDLLTWLQSKDIQSDGDGDVFKKQLSQKLITKLPVSIFILEPFIEASNDFTIAVELLKSHDCPNSTFLKVFKLIDEDAVDTSQFGIIIARRIHSETDFNIQQRFIKVLWDLIDDKQVKGEMDTFLKVTDPLIARNLVEISSEDLIDSLKPASREKISEIVLTEVLKGHRSSKLAEWINKAIPNEYAVSLAKKAVNDLQSDIELKPFLDFINVTSSVDALAACGKEFFEILFELVFKHETTEDEEKEIFKAVKQNAGSLGKHFNQEWINFIHPKIALENFSFKDIVKLSKLLASLSLTKEQLTLILPSEAAVKHLITNVGSMFILNIVCEPEKHRLFEAIYYGKINPGPIANLSSTTRFAVFYSYLAFETSKNAGVKEKGIFAKTSLYALLTELAIEYKSENGLFSTSLNDFQGYHELYIIIDKILQDTRFDYRDLLETIKEPESRSHLVLRALNDHLKTHGRRHISFDIIDDKAFDGEDGEAYHMVRVCEEVGRKTIFAETNFNAAINWCENYINNKQQDNASWLFNVEGRNEIRDAASCSILKLFGVLIENVELKPKLSDFMLCGFVCAMQTITDNFHTVEGRHYFYSHLAAVYCLQLFHLYDTIIAKQNRNAALEWNEFYRPAAVGHIMSWVFALEPSANAGFPQYLINKICLSAGMLTPLEIKEALIPDEISSLNEPLGLGWDNYDEKSKVIIKFAIRLLFGKSNDTVKFLAVFLLKSLMFDMYDAEKLKAVEELPPTENAQQQVEGEDDETMEQQLKELKAEQKKKLPELFEKVLSPQSSSEIKVLPKLMVWDSLIHFLSELDVITRVQYTLALPGVYTDEILNVLFELLPKDPEKRLKELSYKGKLSIQHLFAQKFDFHLPLATTVDHYICNLFYRTLSTLPSIVRTWYMDLPRSRSGEVHDYIKRYITPLLIARELNSLGNVKRGRLTVKVLAAVNEIDAAYSLEDATLSLKISLPDDYPLSKPIVDTHRAIVNKDLLRKWLLQLILFLSQQNGLMLDGILQWKRNIDNHLEGIEDCTICMMTVSTTNYSLPKIKCKMCKKKFHGDCLYKWFDTSNNATCPLCRSPFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z279</accession>
    <name>A0A914Z279_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z279"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6002.t1">
        <property type="protein sequence ID" value="PSU_v2.g6002.t1"/>
        <property type="gene ID" value="PSU_v2.g6002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.50:FF:000003">
        <property type="entry name" value="Autophagy-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6002.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35323" checksum="53631E4AE50951CD" modified="2023-02-22" version="1">MDNLVNSFKSAALSVGEFLTPVLKESKFKETGVLTPEEFVAAGDFLVHHCPTWSWAKAIDDARTRNYLPVDKQYLLTKHVPCHRRCKQMEYDSNLEKILSDGTGEAGDEWVDTHHFAPEANQGPKDIEINLGEKSTPLKADDNDDEDDDAPAVDMDAFMEGGDAEEDDPFRYVPEKKKESDVGDEQDILRTRTYDLHITYDKYYQVPRLWLLGYNEDRKYLTVEQMNEDFSEDHANKTITIESHPHLVNVQMASIHPCRHAEVMKRLIEQLAGSGRVLGVHQYLLIFLKFVQAVIPTIEYDYTRSIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2A0</accession>
    <name>A0A914Z2A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2A0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6203.t1">
        <property type="protein sequence ID" value="PSU_v2.g6203.t1"/>
        <property type="gene ID" value="PSU_v2.g6203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="12">
        <location>
            <begin position="483"/>
            <end position="628"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="314"/>
        </location>
    </feature>
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        <location>
            <position position="403"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
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        <location>
            <begin position="284"/>
            <end position="289"/>
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        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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            <note>catalytic</note>
        </ligand>
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        <location>
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        <ligand>
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        </ligand>
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        <location>
            <position position="336"/>
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        <ligand>
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            <end position="586"/>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6203.t1"/>
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    </evidence>
    <sequence length="628" mass="72071" checksum="5132105D20B91F15" modified="2023-02-22" version="1">MGIHKDAASFANFDEVSIYHIDLDLKVNFEQKVIDGYAVLRMKCHKSTNKVILDSRDLSIKDVHYNGDSMPYKAVDHGVLGQSLNIDIPHTESGKEFDLVVYYCTSPTASALQFVDKELTADKNQPFLYSQCQAIHARSIIPCMDTPAIKQTYNARVQVPKGITCLMSAIGYGKDNRENDAKVKEWHVDGSYKDGLDYIFYDGYEAFLFKQPQRMPSYLFAIVAGDLEKRDISDRCAVWAEPSMVDKARWEFEDTEIMLKTAEELLGKYRWGRYDLIVLPPFFPFGGMENPCLTFVTPTIIAGDRSLTNVIAHEIAHSWTGNLVTNANWEHFWLNEGFTVFCERKIMGRIYGEGVRQFENICGWEDRMLPVINETFNPTHEFTKLCPCLNGIDPDDAYSTIPYEKGSALLLVLEQKLGDSARFEQFLRDYIDKFAGQSVVTDDWKQFLYAKYSDKKDVLDSIDWNGWLLEAGVPPNTPEFDDETLKDCRHLAKVWTDGTNEEVENLDTKVFNDLSSDMKVKVLDCIETSGKAFTGERFLKLFKKYDLENCGNCEVIFSFSLIALKSKYKPLVPFMIDFVTRQGRLKYVKPIFNKLFKWDEMRELAIAKFQENVPFMHPITAQVISKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2I3</accession>
    <name>A0A914Z2I3_9BILA</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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            </authorList>
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            <begin position="6"/>
            <end position="30"/>
        </location>
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            <begin position="91"/>
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        </location>
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            <begin position="114"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6921.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16000" checksum="7B59E79AEFE38752" modified="2023-02-22" version="1">MEAEDLLIIQLVLTLLFSFVALGTSSFVIFRIFMRERQRLNETEKHAFELYDAIFQSFIPRTLSDKLSNIYKTEVDAHAMNDKPIPPSTKQVNPNQNAQPGAAQPPGVAAAPQQPAPATPNAPGIPAPAPSTPAVAPAPALIQAPVLPP</sequence>
</entry>
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    </organism>
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            <authorList>
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            </authorList>
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        <property type="gene ID" value="PSU_v2.g6104"/>
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    </dbReference>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6104.t1"/>
        </source>
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    <sequence length="277" mass="31718" checksum="10FBE77E827C1C80" modified="2023-02-22" version="1">MDSNIFALILQKEDGYRRLIKPKNGNWREPKEKWDFFKVYAALKQQPEHTSNTLNENLNSTAKAAFNLNKNIKAEIPTMSVIVPQDNAELQQPNTLSSVPNSENRINNSKIKAETSTVLDTIQQKVPEPHHSSESAMHDDESETEIEVSATNDMTSTDGYDSVTDDKGSASRITTIDSPNDAQIFSAYKVSSFEELRYMLCRGDTKMKKKFFEQTVKLFKRTIIAYPNNEIIRLIYWLRKCEMKNLDLYTQEYCKVCENGSKMSVGHLFSLQHLKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5E6</accession>
    <name>A0A914Z5E6_9BILA</name>
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        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
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        <property type="gene ID" value="PSU_v2.g7903"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF288">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Col_cuticle_N"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
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            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7903.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="31228" checksum="CAD6752B6E1401B4" modified="2023-02-22" version="1">MEFKQPIMKSDYYESEEHRQMRRVAFFAIVISTAAVIASVVTLPMLYSYVASFQSHLIAETEFCKTRSRDMWTEMSIIHSHGKTLPLRFKRQYGSSPQPAGYGAGPALNAEPACGCPCQQGPSGPPGPPGDDGDHGRDGQDGQDAQDGRDGDVLSSAISAEPCIICPPGPPGSQGASGNKGPKGPKGAAGENGPNGKQGDNGLQGPQGNMGPTGPLGVPGSKGENGRTVEANGPAGPRGAPGAQGEAGQAGKQGKPGHNQPGETGPAGDNGAPGPKGAPGQPGPSGLVGPQGEQGGCDHCPTPRTPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z684</accession>
    <name>A0A914Z684_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z684"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7454.t1">
        <property type="protein sequence ID" value="PSU_v2.g7454.t1"/>
        <property type="gene ID" value="PSU_v2.g7454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7454.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35253" checksum="505BD8718635B430" modified="2023-02-22" version="1">MSPENATDYQKDVESVVDDLINDTSISAASDYTSANDSHDEVQIVKEVIVTQRTDGPAENKSHGNNSESSNELTFYTADTHPEKWNIEDIEAALSALKITDNDAATVDKSLKMDSGNNAVIASKIDADKDVVDVIEVAENDCDDDDDDSAALQNRINEVLSYFNKNNAKENEQEDENLQDGDDLTQKFYSNFRIPFEKEQTEKYAASEFSNEKVLSLLTENSTNMSLEQLKLLEEFRVCCICREYTKDILAAKVLHKIRAIQDQRERNLQELEKQFQERMVKLNSQFENTKFELMDKFYDNESSGDDIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7G6</accession>
    <name>A0A914Z7G6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">procollagen-lysine 5-dioxygenase</fullName>
            <ecNumber evidence="3">1.14.11.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[collagen] + 2-oxoglutarate + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16569"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:12752"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:133442"/>
            <dbReference type="EC" id="1.14.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.11.4" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z7G6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8629.t1">
        <property type="protein sequence ID" value="PSU_v2.g8629.t1"/>
        <property type="gene ID" value="PSU_v2.g8629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008475">
        <property type="term" value="F:procollagen-lysine 5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF45">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="280"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8629.t1"/>
        </source>
    </evidence>
    <sequence length="371" mass="43486" checksum="170C1D61B8A0EDD3" modified="2023-02-22" version="1">MKLCNHFALEQKSEYIFALDADVHLEPKSLDHIIQRAKAYNLKILAPMVAIKGKMFTNFWGSVSANGYYERSQDYLDIVEGDLKEFWNVPFISAAILFSAEKLQFFMEAYNYERKLDADMSFAKFCRDHGHFMYVDNQEHYGQLLSTEQFASLSETLIHAEVYDYPANKELWEKRYIHPEYFHYIQPGIEVPLPCPDVYDFPFLSLRMSKEIIEIMEHFGTWSDGKNFDRRLEGGYENVPTRDIHMNQVGFEPQWLQIIDDYVAPMQEKVFTGYYQRPIKANMMFVVRYRPDEQASLRPHHDASTYSIDISLNKRDVDYEGGGVRYIRYNCTVPADEVGWSMLFPGRLTHLHEGLPTTKGTRYILVSFINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8J0</accession>
    <name>A0A914Z8J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8164.t1">
        <property type="protein sequence ID" value="PSU_v2.g8164.t1"/>
        <property type="gene ID" value="PSU_v2.g8164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8164.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10939" checksum="CAD0A614C19F099A" modified="2023-02-22" version="1">MSKFFKKDCNSSDSEDDKSQPKKEKLNKQKTKKVRSVSAHPPPKCSIEKFDLKDKEEIRKYFLKPVKPAAEKVIDKKRKQRNYSVQRQNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8X2</accession>
    <name>A0A914Z8X2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z8X2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8361.t1">
        <property type="protein sequence ID" value="PSU_v2.g8361.t1"/>
        <property type="gene ID" value="PSU_v2.g8361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="8">
        <location>
            <begin position="152"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="9">
        <location>
            <begin position="635"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8361.t1"/>
        </source>
    </evidence>
    <sequence length="712" mass="80345" checksum="3EC2FCB0E4B227C8" modified="2023-02-22" version="1">MGIWRDIWISYSSDSLLMKQMSPLITHSPSKFNVQIDVEIFCNPRDPLSFTLLSSLPEISIKETKDFRVTCDKSGITNVSHQIIVPEASIELWWPNGYGNQKLYTLQTNILSTSNSSAVFSSAQKKIGFRYIELIQDLVDPSRTDKGRHFYFKVNSIPIFLKGSNFIEVSDFPGRDSSFRTNFLLKSSKEANLNALRVWGGGIFEADEFYALADEYGILLWHDMLFACSLYPVDSEYLSNVYAETISQVSRLRYHPSILVWAGNNENELAIMSGWWYVPNYSIQEVIADYVKLYRDTIGPVVKSLDPSRPYLLSSPSNGVKSEKEGGVGSDPNSEMYGDIHFYNEYINLWKDGSYEIPRCATEFGVQSIPLRDTLLSYISETEYFYSSKSFTDRQHHTGGVATLLSMTFNHFENPKECSSQNGGNVQSCPYVQKNSSFLAPFSYLTQLHQGLSMQAQSEHYRRWRGIINDAGKGNTMCALYWQLNDVWAAPSWASIDYNLEWKAIHYFAKRFFAPIIISLYLDGNGLLQAYIVSDKTSNITSAKLKIEMFAWTNAFTPVYTQTQSVTVASLSSTFIKIDSGFAALSTKPSDFIIRGTLTASDGTSLSPTAILHPDKFWNLSNFGKVSISNFKKIDSKTFEFNVIASSMAPFVWIDLTPTFKQKNPFVGFRFSDNAFTATSPTTTVQLSLEIPPTTVTAADLIVCQLETCFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8Z3</accession>
    <name>A0A914Z8Z3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8Z3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8381.t1">
        <property type="protein sequence ID" value="PSU_v2.g8381.t1"/>
        <property type="gene ID" value="PSU_v2.g8381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8381.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10712" checksum="15AB2FBFAA634C97" modified="2023-02-22" version="1">MHRLHLIDSDSNSDSNSDSGVGVATSHIKSKTKKRFNFQSRDAFQVAAADNCPDGSKSGGSNAKGYFEATYAETCNDLVCQKGLKCVQVNKQFAKCCGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9P2</accession>
    <name>A0A914Z9P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TLDc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9P2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9390.t1">
        <property type="protein sequence ID" value="PSU_v2.g9390.t1"/>
        <property type="gene ID" value="PSU_v2.g9390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF108">
        <property type="entry name" value="RE10231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="178"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9390.t1"/>
        </source>
    </evidence>
    <sequence length="387" mass="44328" checksum="7338144AA399C732" modified="2023-02-22" version="1">MGNNKSSHASTSHESHHHHHHRHEDGPNDVVKQIFLAVSDGADTLSFPQLKYKLGDLALPLFRYLSDDDESLSPMTISQFGKHCQGLVGTSTDIYVKIIQPVDELLKVCFDCAGVKQPNHDDKFLNSLMEDMTSDGSSYDKIVSWKNASCPGLCSSIREKVFDVFYDRRHVNNEYKSDILTSAQMYVLQGMLPRTIYFPHNRSDVNDFNGSLWTLLYSSEHQGISMNRFEATTFHYKGPTVVIFRKLDHSVFVIANDEEWRHSTKKFGGNNCILVQMFPEFKRVDGNEMIYCNFKLRSSVFGIMFGRHFSVNDDMSDVNALEVWGCGDDNILVEQQKQKMRIKRAAEQKGTVPLPGNWDENPDKSIMEMAGYQFSTERRDDRPPDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAK7</accession>
    <name>A0A914ZAK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9692.t1">
        <property type="protein sequence ID" value="PSU_v2.g9692.t1"/>
        <property type="gene ID" value="PSU_v2.g9692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9692.t1"/>
        </source>
    </evidence>
    <sequence length="548" mass="63158" checksum="45575C152C86B107" modified="2023-02-22" version="1">MEQELHPGPEHEDFEFMEAFDGEELIPVSEPEVEPDEAFLLVVEPFVEQCFNKWLEFINHPDATVKSSNLLCDMLMENARSAVYLAQPYLHHQQANRIESMLKFRFLPFTTEYRRRKYLQDRGLYQKPEEYLIGVELFTHGAPQGNSIRERRNMVAVIPIKKTLESVLSIETLADSLVMPSDYSNVRTLCHPFAGTRAQNLLNKVGEDCLLLELYMDEFTTSCPIGNTSTIYKMAAWYIRLLNFPLDMISQLDHIMLACIAHAVDVMEDLQEIMRLILLPQLKNLETNGITFRYQGIEKTFKVILYRISADNLGFHQFIGFTRCFSKNNPCWMCTETAETLKTIWNLNPRKMRTREEYDRLIAAENLQHRLLYGIKTPCCLNELQYFHCMEDFSVDYMHDLHEGHFLRLIPLVVRDAIAAGYTLDVINGAIVGFGLVGSDGNNPLRPIYLSPQIPDTGDNLGGYTAKSTGVLVRLLPLMLKCARIRLRTPSWNVFMKLQRIIDILYAPDVTDATIEMFDTLVKSYLKDYIAIGGKMTVKPHKLLHYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAL1</accession>
    <name>A0A914ZAL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9698.t1">
        <property type="protein sequence ID" value="PSU_v2.g9698.t1"/>
        <property type="gene ID" value="PSU_v2.g9698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9698.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14172" checksum="5B66849C9CB2C5C7" modified="2023-02-22" version="1">MHEYERKLDEFVKSPEILEELSIKVYNRKLMQLLREIIRDFNTVPCPLSEQELKRIGIDRTTMPQPANVSHKSKYQGGRGDMFNPAWQPNAQPMNVRRPYNARGSKNNDGQNKNNDRKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAW4</accession>
    <name>A0A914ZAW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAW4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7396.t1">
        <property type="protein sequence ID" value="PSU_v2.g7396.t1"/>
        <property type="gene ID" value="PSU_v2.g7396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037756487" evidence="1">
        <location>
            <begin position="22"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="183"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="490"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7396.t1"/>
        </source>
    </evidence>
    <sequence length="777" mass="85358" checksum="B81A660F207BCD30" modified="2023-02-22" version="1">MAGKLFLCFLIFVTAFEFAYGKDATDTKYAIGNEVVIASIRKIQDTCIFPNDLLFLRRLAWVESQDGDSLKSFWNSDKGKNGIWQTTSSMLSQVKNSGGQALTDLQTQLGVNISDLNWSKGDLDIPLNDAALARLYTNMKSVIPLDINDQAAYWVNNFNPSGTVQQFISAVAEMPKCKPPGLDLIFIIDDSGSIGADVFQNVRNFMTTIIAALQTGQSNRVGIVRFDDSAFLDLTLTYNLDYASQIASSIIYNGAGTNISSGLSLTFQQFSQYGRTDVPMIALLITDGEDSEESVVVQANNLKDFGVNLFTVGVGSAATTDLLIWSSIPHCMYYYSLNDYAQLAQSFPELLNSQICDVTAVIPTSEACVNGTVDQGQYVFYQIPADPTAGVTITLEMDYGAASIYISLTTRLPSAADYDFYANANVELPGQIYISPDQLQTGSNSSTVYAAVVGLTPENRYTLCNEKYDTIQNYTTAAPFTTNSSCISLDLIFILDRSQSVYEDYYNTNVTNFVLDIANQFAFHDEATSGDPAFARFGVIEFSSTPSVTIPLGNYSRTNFNSNVTKLIAYSVDEGTTRLGDAFMAAFNQFQQNSIMKNKAIILIVDDLTPENIQDAKDALNKLKQYVSLPIGTIMTGSWGDLQDGYKRLSDLLGKKNVFPSMDDNQDDILNRIDTTYPCTALPACSAIIFVEEASTAIGQPSKIKFLQLVSKLVNSIEHTPNQRFGLALYASSLSKDVEFQMFDDFNRTLNDYINSVTDNDSPNGGTTNLIPQVFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB95</accession>
    <name>A0A914ZB95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB95"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7523.t1">
        <property type="protein sequence ID" value="PSU_v2.g7523.t1"/>
        <property type="gene ID" value="PSU_v2.g7523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7523.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25261" checksum="551CEC5ADABA8192" modified="2023-02-22" version="1">MHRYSNFKATSFNDLILSFSGKFFPDFRSKSINSNIVEPVNAIVYIPLNLNWPGEHNLVVIEFPEGTDFGVEPITLAKDHVQTYLENLIVVGYGKYEFKKNMHIDETPPQMRHTNVPFQRDRYFDEKEGTPNGSHTVISPDCNFIEEATKNEVKCESVAPIYEEPYQSTTITTMTTSLATQTPTKNQENEISVNSKPENNASIIEFQWILLIFLFTVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE63</accession>
    <name>A0A914ZE63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZE63"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8560.t1">
        <property type="protein sequence ID" value="PSU_v2.g8560.t1"/>
        <property type="gene ID" value="PSU_v2.g8560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8560.t1"/>
        </source>
    </evidence>
    <sequence length="511" mass="58808" checksum="EEEF7567367FA8F9" modified="2023-02-22" version="1">MCLSCIWKVVINLQKGIICRLFRYHYDKAVKYALQAPKIQRETYKRERFDSLKVDPFIDFISSDIVVTGLPFGTKTLKLSNTKLEIPSTLRLQKHFEIIEMFENHMQERGQSHLVLPRSTMFHLLEVCSAKRTTAITCVDYFISNGIDGMNDIINLIDKWGQKGTFTLHDTKVLKHHVLESLQYLRTQYLVNVNETSNVPSHCAKHALSSATDGRMQANERDHEHDGFCERCLKLVKTMEKVNSLAKLQKENIEADDIVDQRLLREAEEDLSVAQNAIESIKKLQEHFLKSVYSDEYRKFIIENVIDDQTALLTIDFAQKYLQDWYKQTQQQYFARRGMSWEVTHVFIKKNGELLEHTFIHLIENEKQDARTVLAILKDVLLKLKEQNIVKVVARTDNAGCYHCKDVLMSLKHVIKETGVKILRWSFSEPQSGKSSADRKAATVKTRLRAHLDKKNNIESEADMFTALTNPHPLRYMTITRATVDSSTPVPNSVDSTPLPNSAPIAPKTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XPQ8</accession>
    <name>A0A914XPQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XPQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g100.t1">
        <property type="protein sequence ID" value="PSU_v2.g100.t1"/>
        <property type="gene ID" value="PSU_v2.g100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g100.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35511" checksum="88A3D413DE4599B8" modified="2023-02-22" version="1">MGSGYPPFHEFILSSLSNTVEERPEALAFLSAENEFNPVTFKEIQNAILSVAGYFQASNCKKGEIVTISLPNTWHYSACYLGAASAGMVTSGMSPDFTAYETEYQLANSQSKAVLTTGNNLNKIIQASKNLPHLKIILYIGALPSTIAPTPLKLVNFDEIISKEYPFNPKLIQFNVDEDLLALPYSSGTTGMPKGVMITHANFMIQISILAMHHMTKIDVAFPPDENRGPEYKIHFLPSYHAYGFAGLCLNILKGCTTIIMKHFKAHLFLSLVEKYKVAQLNLVPMLLNYLSESPDVEKYDLSSIRFISSGGLRYDKVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQX2</accession>
    <name>A0A914XQX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XQX2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10400.t1">
        <property type="protein sequence ID" value="PSU_v2.g10400.t1"/>
        <property type="gene ID" value="PSU_v2.g10400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17326">
        <property type="entry name" value="MFS_MFSD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10400.t1"/>
        </source>
    </evidence>
    <sequence length="535" mass="59592" checksum="E0A3B984C5A50B7E" modified="2023-02-22" version="1">MAERYHEVRGRGRTMTTARARGRTSSINVVSENFGATDPFGIIFEDDEILERRYTNATAVRSRLNTISSIYTIKEKELKGEILDDEPKTNWTSIYTLTLVTIFNGMQFSVFFASLWPFLNTVDPNAGATFFGLITSGYCLAQTITGPIFGLWMNKSGSIKPPLATGIIIMALGNVLYAFIEEFSQTNRKWAMLVARAAVGAGSGCLGVMRAYGATASTLKDRARAVTCVSAAFVIGLTVGPGLQVAFTPFGYPGKLKIGPIRIDEYTSPAIFAVLVDAVSVCVLIFFFSEHYAGLMVKQEKDDPYFVLPSFKRLPAGICIFTQFCMMFVITNTEAIGSMYSIAMFDWTNSDAVYYTGLIQTVGGVVSLFTYLAFAFKIGRYVSQSRERLAVIFAICLALIYHVITFPFPFLPNDVDQKNRLNDQGKNETVGCLDSYDWCGYTKKVPFLLYAISNGTMQSVSLMAGSFARTVGPLLMTTIFETYGPMLIWGIEIIVLATCVSFWIIFYYKIEPLDCNPDLQPGEYYKYKKGYKYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS16</accession>
    <name>A0A914XS16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XS16"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10784.t1">
        <property type="protein sequence ID" value="PSU_v2.g10784.t1"/>
        <property type="gene ID" value="PSU_v2.g10784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10784.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24375" checksum="38D857C51D4D555C" modified="2023-02-22" version="1">MAQFQYFTTLQFDAIWILAHIASGGTEEQTAAIVEADSIPHLIRLLNSENKEIVGQALLGLAHIINKNAKNRDKCINAGIVPALVKLATSESSNIAINRNIAWTLKNICKYSNSNDFVPIQVIQEILPLFSKFLKNEDSLILSETLMGIANCGNGSDIRIQTIINHQNIVKEVIPFLKSFNSKIQHSAFNVIKVIANGNIQQRHEFMTNWSNFENLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS87</accession>
    <name>A0A914XS87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XS87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10848.t1">
        <property type="protein sequence ID" value="PSU_v2.g10848.t1"/>
        <property type="gene ID" value="PSU_v2.g10848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10848.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36415" checksum="D9452F7E654A38AF" modified="2023-02-22" version="1">MSLQGKVALVTGASRGIGRGIALQLAQNGSKVYITGRKPEQSLGTQYTNLPSLEKTAKEIESRGGQAVVVYTDHSDMSQVKTLFQQIESENHGILDILVNNAFAGGRALTSNGEKLFFEEEPEVWDLINNVGLRNHYYCCVFASRMMVKRQPSQGLIVNISSLGGLRYFMSVPYGVGKQAIDRMSADMGVELAPFKVTVLSLWPGAVKTELTSTLIERNELNIKKSKDISEAATQMIMTNGESIEFPGKAIVALASDQNVHRYNGRCVLTADLGQSYGFKDIDGRQILSPRSVNYAFANDIVKFPGSQTLANFIPNFFKIPGWLLTVASSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSA1</accession>
    <name>A0A914XSA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSA1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10861.t1">
        <property type="protein sequence ID" value="PSU_v2.g10861.t1"/>
        <property type="gene ID" value="PSU_v2.g10861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10861.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="13466" checksum="730565FD447E7648" modified="2023-02-22" version="1">MLVVDSDGCCVSTVAGRIVDSLATITVAEGASVAVIGFIVVCSAKIFVSGFVVFPSSIRTTTGTIFCFVGEGSAVEVFIVVSTVLDVVTGISVISFIVETLSATMIVVSGRGSEVVLPPTTTCPAPSGAIGTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUD3</accession>
    <name>A0A914XUD3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WAPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g11563.t1">
        <property type="protein sequence ID" value="PSU_v2.g11563.t1"/>
        <property type="gene ID" value="PSU_v2.g11563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="3">
        <location>
            <begin position="179"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11563.t1"/>
        </source>
    </evidence>
    <sequence length="712" mass="81265" checksum="B457361BEC010A9F" modified="2023-02-22" version="1">MIIEEDKPANIQQAQKRNSNQRDEGDPFVYDEADSNNSAKAKRLKTEFSLLRHKQSNSKVKNELSAVKKSPQPKYRPTWNDNKDDEDGDEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDEDGDEEEEEMLTSSQESKSSNITKQSTSFNRHTSAPTFASRSKPSNPSSFLDQRSLKRVSQAQACLKSGEQEDFTQDFDYFMTVMEKEGTTENTIFLSLQSMTKKAIKIEFRNFLRRRSALSRIFKVIFSHLDSTRICAVGAVFIYFMARDRQCFNADESFVSLIMPLLKIKPEIDDKAFDGAVKTLWPILEEWSKVTSELINKPVNTGMTKETFNVSYLTLEALALVCMHKHDKNLQNHLYNIDCLHWIIVKVEKLTKKLSKCKESGDGAVGTIGELNRCMRILETSSVYNTNNQTYMMTGGNFALLQACTSVMQTFKKFVVYGIESIRIVTFDSMCTVLRVLLNMTHDNELCCTKLGDMNNFLEFCLNCITELSPKYAPKDKYFDIILLCCALLVNIAEKSTTIRSRLIEMNPRIYDSETKSIKEDNTITAFTQLFIRHESAARTVDEEFDKEFELDDIPDDDDETNAIADDGRLHRGEDMSESDALQAIQTAMTKADSQMEDSVMASYFGILLGCLIQRDTQNAMKVREMMPSKNFTPLIEQLNRFKEFMEMTHKKTNNSRTVERIVGALQGYNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVI2</accession>
    <name>A0A914XVI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1195.t1">
        <property type="protein sequence ID" value="PSU_v2.g1195.t1"/>
        <property type="gene ID" value="PSU_v2.g1195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1195.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="25436" checksum="BCAD44AE3E6E71A4" modified="2023-02-22" version="1">MSGGFSAYGNPNQSNPYQSSANPFQGGNPFQNNNQFEQKWKNGRWEFTYRKNNPTGQTFTQDDFERIWREFQRKTQDPRNASYDQMFKEHRQRVWDDFSKSRAEAWRKRSEEHAKKYPFDNMRFNPSLYINWEKVNKYLIIYVMIFFIIGVLQSVWKGDSENESKQKRRVVYTENPPEKTARERLEEMINRPPPSEATREWYDDRPPGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW09</accession>
    <name>A0A914XW09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW09"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12119.t1">
        <property type="protein sequence ID" value="PSU_v2.g12119.t1"/>
        <property type="gene ID" value="PSU_v2.g12119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF1">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12119.t1"/>
        </source>
    </evidence>
    <sequence length="746" mass="85308" checksum="BBE330CD8C771674" modified="2023-02-22" version="1">MAFEQLRDLFQTFLRNTPIEEDIVQTCIEVNFVGRLEGAELDFSGVEDVWEAITDELVKVVLSENGEDIIVQIENGEFSLKNVITVLGFAMEKISEKTVQSSITALLAARIYLLLCCLTSAHVFGIYHASLFTRATACYRNVYTIKQLRGDISTSKPKKKVQTKNKTFGTTTIINATTVANASQFPADIEDDASPQLIKAMSNTLLHSLDQIYIYLQQDTIGTNNKVFSSIIDLIRSICRFDYSSTTRTTKIESYQQFKRLERFSDKCFALAHEAMKEKHNHEDMVLSMFCLPRLTFKSFESKFMKGSLPQSTIQMADVMARFVKERFDIDKEAYCIEKDGKTMFSYCNIGEEMETCNFGTDDENRDLIYVKRLAENICHQCLAERKDYRENSLKIAVNFVKLLPPKLVQVKQFFFFAVNYGYLNNQRSRLVAVDLVSILLETFDVASFPNGVTAFENVDYEFGAIAEAVEYDDSNFHQKNPTFKKNWENFLYFTGEETFQPRNAMLQLLVRATMDKLAAVRIRGLCAILPFIKTQEGYEEITKETKEFISHSRAEVIKVLSEVRQHDEKVDRDTPICSQATTQGTRAETPVPSHIHQAAQNAAEYFTNVSVAPFADLMIMRCNDKAPSVRRWVVPIIEALLTVESNRGYQKVLLKKLQDFCRDPTVSVRKDGAQAMTAIVRDEEIFKQAWLHTVLPMVNDREETVEKSCREYFFNKIVQPIICDDGSDSLSWNLMIEIAKTSEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWD6</accession>
    <name>A0A914XWD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12248.t1">
        <property type="protein sequence ID" value="PSU_v2.g12248.t1"/>
        <property type="gene ID" value="PSU_v2.g12248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="155"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12248.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31045" checksum="5F5A860A39E849E0" modified="2023-02-22" version="1">MAEYTKAFEKYTHRSSSAQPSFDVYRNQVLALMADLKHKNRGKQSIDQQAAMGIIRSTAAKRYKKYEVNNEQLLDLIFAVLKLQPTLKGYVIKLIEKTYGDIGLASRIKQLDFRHTKLNFPFADADLHEVREKYLSIPQNVNINFVNNVAHLKVLVHQLEEVSKSDYPYVGLDAEWSPYLSKSKASILQLALQKVIYIIDLDALIDKKELLDFFDKLFGNDKICKIGFRFSEDLTQLRGCAPNCLSLYEPKNLICIQSLFFDVSFFYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWJ2</accession>
    <name>A0A914XWJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWJ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10902.t1">
        <property type="protein sequence ID" value="PSU_v2.g10902.t1"/>
        <property type="gene ID" value="PSU_v2.g10902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10902.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26438" checksum="128770057C6015FC" modified="2023-02-22" version="1">MRNHFDHYNCTIDGGINQFSIYLRSAYGSALFDINNELTERELNIIKKFTEQVLKKKSYVAKGEPSVHMFHVLQQKEVQSHLLMLFHGEVSKQLIDKMDKRDLFLQACEIIEKTKELHPVISGLFIFAALIAEATVDDDENYLDKIKNIVDDDFGIEITTGPLSFEVLNEAVDHFVKAKKEYFVDNDEDEAAEISSELDSVFDDTENEEDFFGASFEDSRNEVTKYSVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWN6</accession>
    <name>A0A914XWN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g10177.t1">
        <property type="protein sequence ID" value="PSU_v2.g10177.t1"/>
        <property type="gene ID" value="PSU_v2.g10177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037484047" evidence="1">
        <location>
            <begin position="18"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10177.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="25885" checksum="A201C1E848BAFD93" modified="2023-02-22" version="1">MVRVAILVLCLAVGVTSFGFGAMGGGGGCGGGCAPPPAPCGGGCGGPPIGGGCGGGGGCGGPPIGGGCGGGGGGCGGGFGGPPPPPPCGGGGGGCGGGFGGGAPIGGGCGGGAPIGGGCGGGGGGGYGGGAPIGGGYASAPSFGGGAPQGGGGYAQAPQQQSFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPHNNLLLNKAILLAQAVVVDMLLAKNKMFLPFSIYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWT8</accession>
    <name>A0A914XWT8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11431.t1">
        <property type="protein sequence ID" value="PSU_v2.g11431.t1"/>
        <property type="gene ID" value="PSU_v2.g11431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11431.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="16487" checksum="FC5D0BE97906300F" modified="2023-02-22" version="1">MAAASYDITAAESPAYAPFFGYAGCAAAQIFTVFGAAYGTAKSAVGICSMGVMRPELIMKSVIPVIMAGIIGIYGLVVAMVLKGKVKASSAGYTLEKGFAHMAAGLTCGLCGLGAGYAIGIVGDAGVRGTAQQPRLFVGMILILIFSEVLGLYGMIVALILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0E8</accession>
    <name>A0A914Y0E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0E8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12688.t1">
        <property type="protein sequence ID" value="PSU_v2.g12688.t1"/>
        <property type="gene ID" value="PSU_v2.g12688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.310">
        <property type="entry name" value="membrane protein fhac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF47">
        <property type="entry name" value="TRANSLOCATION AND ASSEMBLY MODULE SUBUNIT TAMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12688.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27637" checksum="1C3889A0D180C9FF" modified="2023-02-22" version="1">MGPVRFEQDYFVDKLFDPLVYWDQGSYYHEGKLDRLRESLTKLDYFSVIDIQPRPDQADENGEVPVDVKLTRAKRTIYTAGLSYGSESGPGVRGGIERRFLNNRGHKMNTQLDYAQKRKSLVTSYRIPAFNWLDGWYTFAASAYDEQTDYIDLRNFKLIASRSGEINEHWTAIASVNALRERWRYASGTEFTDAVYNTSTLVYPQMVADYVNVDDEMFPRKGISGAATVRQRRAALVHPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0H1</accession>
    <name>A0A914Y0H1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0H1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12282.t1">
        <property type="protein sequence ID" value="PSU_v2.g12282.t1"/>
        <property type="gene ID" value="PSU_v2.g12282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12282.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17736" checksum="6ED091CA70B407F8" modified="2023-02-22" version="1">MTDKDKAYENIRIDQKSGPQFASHIVKTRWPLTELTADYPTLSLTSIHNNNNNCNNNQFQKDINPEIFYDFFGDHSLSSSCNNGDTLGRRKDKKKKCFNEKYPKLESVLEDTGYIELKVSTSKESFPRRSLSSKGGDTKSLGRRKDKKKKCHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y120</accession>
    <name>A0A914Y120_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y120"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12916.t1">
        <property type="protein sequence ID" value="PSU_v2.g12916.t1"/>
        <property type="gene ID" value="PSU_v2.g12916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12916.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27086" checksum="1C682FD0833692A4" modified="2023-02-22" version="1">MDKRQKNRNNAASKEKIIQAIKKLNDANPQHKIAKKRLQARLESLETQKQQQIRRKSSKEKEENSKCPQSGNEKTFRSDSEPQTMNLWTIDDSLKKGHRTIDRRQKFIKKQRSALEKDLASSKKAEEAIKLLKQQIEYKYDMVSDGLMKLKQKQKGDIMAMKDQIKCISRQNEENAESERNARGIVTAIAQNEITPISSLIGEFAVGIVRLFLYSTAALRDLIFQRGEKPINVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y147</accession>
    <name>A0A914Y147_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y147"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13174.t1">
        <property type="protein sequence ID" value="PSU_v2.g13174.t1"/>
        <property type="gene ID" value="PSU_v2.g13174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13174.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16780" checksum="1D9C00BAE26E5AA4" modified="2023-02-22" version="1">MLPRISRIPLTTFKAGLTDSISVKQLSTYPINDDLYQLTDEQKQLRKTVFNFAQKELAPYAGEIDKTNNFPQLREFWKKLGKNGLLGITAPAEYGGSEMTYFDHVIAVEELSRASASIALSYGAHSNLCVNQLVRHGNAAQKEKYLPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1S7</accession>
    <name>A0A914Y1S7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1S7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13411.t1">
        <property type="protein sequence ID" value="PSU_v2.g13411.t1"/>
        <property type="gene ID" value="PSU_v2.g13411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13411.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19299" checksum="9E3F96EA16BD04DE" modified="2023-02-22" version="1">MPKQQDIDTIRNNSIEISLSYYLKFFPNQNGNAVIAFKFINELKDVIDFKTTFFIKSCGIEKELTGEYQRDFLRKIGKHLPVKFEVILCSTKDLFDEEKQFFDEHDELVLQCQGSLNTYDTSYETEHGWKFKSGKKSRQPYRPLEFDWDIKLIARDGIVQVSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y213</accession>
    <name>A0A914Y213_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y213"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13496.t1">
        <property type="protein sequence ID" value="PSU_v2.g13496.t1"/>
        <property type="gene ID" value="PSU_v2.g13496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16129">
        <property type="entry name" value="Ubl_ATG8_MAP1LC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000149">
        <property type="entry name" value="microtubule-associated proteins 1A/1B light chain 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13496.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14542" checksum="08792265A367F0D2" modified="2023-02-22" version="1">MSASGYIPSFKERKNLAERIRMVEDIKRQQPDKIPIIIERYEGERYLPLLDKCKYLVPNHITVAELMQIVRRRLQLHPDQAFFLLLNEKSIVSNSMTISQLYQMEQEQDGFLYMVYASQPTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2B9</accession>
    <name>A0A914Y2B9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stalled ribosome sensor GCN1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2B9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14315.t1">
        <property type="protein sequence ID" value="PSU_v2.g14315.t1"/>
        <property type="gene ID" value="PSU_v2.g14315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037089990" description="Stalled ribosome sensor GCN1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Stalled ribosome sensor GCN1-like N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14315.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="30764" checksum="936C5373AC3626B6" modified="2023-02-22" version="1">MGAETGGGLKTMVLISLLLRKGSAALNSENFNHMKSTWLDCYSKAVMLSKPSMEKAYFTKLNKTLSYFDPKEVEDMLLSNCKKALLREPEVAAPAISHFFKQYANPTDSFAVSFLQIVSTTIVSTNDDVRKHIADAIGAVACHISDGTVLSKFIEQLFDLFKSNSTKLPQRTSVATAILYACKNVETVTNYEPVIAKFGAALPAEANDVVLRLIWIAFAEWIVKVAEMPSSSLPILKKGINSQGDTKSISLRVAAYVFDKFGNVAVDSEILKAANAVYQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4T0</accession>
    <name>A0A914Y4T0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">kynurenine--oxoglutarate transaminase</fullName>
            <ecNumber evidence="2">2.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y4T0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15205.t1">
        <property type="protein sequence ID" value="PSU_v2.g15205.t1"/>
        <property type="gene ID" value="PSU_v2.g15205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15205.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="14956" checksum="753054632D30ADF3" modified="2023-02-22" version="1">MTNNPLIPQSKLPQLGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAHHVAQGANQYAPMTGVQALREAIAQKTERLYGYQPDADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYAPAIALREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y604</accession>
    <name>A0A914Y604_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y604"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14876.t1">
        <property type="protein sequence ID" value="PSU_v2.g14876.t1"/>
        <property type="gene ID" value="PSU_v2.g14876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14876.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34538" checksum="16682CAB835A54E0" modified="2023-02-22" version="1">MMPAKKNAEDKESEPSESESLPSSMPRAEGATLAIPHRYALRTQHQPTHTSTSTITPAADQSSKRSRGRPRRTTDYPTPSTETIYTSASNVSITTNSTAATPSTTSITGPRISPTNPSSSSITDQTTATSTTSTAPTTTPPTSSITVPSLSATTKTTPTQPPSSSTANSDSSKYTALLHTMTDIMYPPNNTESTNTTNTAPEDSPDSPTEEKLSTYCKCLKKYGLRPEYIITDILIDEGAAEVYFLILLLKRLLTWITLILCALTLSLLKIFGEEWKSFVGKCINVNFSGNFRRTTVNHFLQSGRQIEKLKMDVVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y631</accession>
    <name>A0A914Y631_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y631"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14224.t1">
        <property type="protein sequence ID" value="PSU_v2.g14224.t1"/>
        <property type="gene ID" value="PSU_v2.g14224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR1-like winged-helix" evidence="3">
        <location>
            <begin position="569"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14224.t1"/>
        </source>
    </evidence>
    <sequence length="1140" mass="131159" checksum="368AE10323B2A7E9" modified="2023-02-22" version="1">MTNTEPSPDELVSIHDRNQVFEEPDLLRAQFVMRPMNPEDEAVVINAALDNAMNPQNVGMLSLRPRHYTTSQGKGQKVPKAERKYIQPANNKLPCNHFTTIAQLVLFDRRLWKAARINFHQLLMATVLMDLDHKRDFGVFMIKNFEFIYEDFIHDDHEHSASVIALSVQVFTVSSVAQYLLSNENALAIIFETIKLHCHQYIKFSDNNDRFLRYDFATASMPAVLRRALTMFKDALYILLASPMQWTTKMKESFICGIEVYADILTMMQGMDSIKRQIDQHQMIESEWETAFNMQVQVQEITSMLITWTKSNAYIHQRVAKIIIDRILDICSCMPEFQNEKSTRIDTFVASTIEFNVSRDYISIHHPLWRFFGGLFTAGPEILKYYKFGEKILPSDNILYLDSDMSELMETSWKNFEPINGLFVWPISALLEMPLRILVLHAQCHSQLWRRNGYSLVNQIHNYTSPLCRTEMFDRDIQMMQICAAKIESTEFLIRCLERFQLEKWARNVYDDLPLKQALDGVPITPSSTPEELSKITVTASEEFFHLLIMIIGERYQPGIGKSSRLQLLEREILHLLCTRPQTYSVIEKTILLEPNVKIMEKDEALNRVADFHKPASTAAGTFHLKESHRNQYNPFFYHYSKQQHSQAEQYQWREREKCPRHIRACPPPIPPEFETFFEPILRILDNGLFIRLLYFIINRFQKRSRYSSEGLFHRGLFLIGMAMNEQIQRHKKGDPEKELNFVDQAEEIGIFNILRDLSGKSEAESHQNLILWILDKLYEVKDAVNEKKDVDEMATEEPEMETNADEKLAKKKALAAKKREQAMKRMQKMQKAFTDQNNLGATATDAKDGNDFVEVDEEVEFSSFKNAGFPVCLGPYKSEVKLNTSRNVKCILCQETEALTFNGKSMVCCGFLQNSKLFAQYGTADNLEDRTDVFASTTLTNGYSVSTCSHTMHFDCFKLFTDQLWSKERNRARVQILGQHIIDAESHEYLCPLCKRLSNCALPLLPSIDRLPNNVKKFSQTRPTPPENFEEWLSRLVGLANLPLDNAVLNPSSAAKSFKSHSRKRSHSEKSLLQLQEPFDGRLLETVLSSSQPSVVVPLSPNAGELPMLPESRGTSEPEGNAAAAVNNAVVPEEWVQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7E0</accession>
    <name>A0A914Y7E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7E0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14661.t1">
        <property type="protein sequence ID" value="PSU_v2.g14661.t1"/>
        <property type="gene ID" value="PSU_v2.g14661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14661.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15851" checksum="48139380A05A64AD" modified="2023-02-22" version="1">MQAVAPSLTPKEIAQYKPTINIKVEEPDNDDLLFPPRAGEIQAQEENCDEQSEGCYVSDESDSDDDDDEYPPDEEYPDEACDNILEDEDYEDGDDNDDEDIPIPSFPLSNPIKNRDATEESDEESYKTEADEEECDNKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7Z1</accession>
    <name>A0A914Y7Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7Z1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15573.t1">
        <property type="protein sequence ID" value="PSU_v2.g15573.t1"/>
        <property type="gene ID" value="PSU_v2.g15573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15573.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13664" checksum="9B44C4BE23B12A34" modified="2023-02-22" version="1">MLSTCAYQVAYRFNTALKAIQKFSNIVRSDDRDETSPLFADERESEAFCHLIDNIVNLLEKAHGELEEFLQIVLTEMRALKPTVESVKASLKIETNQETRKSEKEELLKNDQQVGYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBU5</accession>
    <name>A0A914YBU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1768.t1">
        <property type="protein sequence ID" value="PSU_v2.g1768.t1"/>
        <property type="gene ID" value="PSU_v2.g1768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1768.t1"/>
        </source>
    </evidence>
    <sequence length="454" mass="52282" checksum="120510D784EBB6C0" modified="2023-02-22" version="1">MAKATEEMDMKNSPSEAAHPPSTPPSLTSGHGGGWAKTEQEEDRVEKLIRDSGCWDQHLRTVECMSDKEDWRKCQDEMSLEDVETVCNIFGQFDILEDAPSSDTSQSSIEDLTKPPVFNDSKPGQLFLLGDWYLNPDPVTKPIWDELEILHKQAMYFAWRSRHREAFKIYKKIFNSYDHKGSHRREILDAMVHSSLRGKHVEPLEASFYALKNDVETFGDQLNLWSTTITIAEIRGGYLVSPIEHISAIIYLCVLAECGRHWNFFDKMDTSFLPKKTNFRFGAKVRAFFLLKHEYSNFERSADSIEKITENLMVKIRKELLQSHTEEEIINARNHVCNDIVKTPKTVNSIEEPPPHACKLDSIVKSHQELDIIRNHFVTKFAFLFKDNQELAAKLCKPSAPAVFTEEQSYQLNDESDDEREKEKSEESLLHSRTFPNRSSPPLKHRSNRTGGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCG1</accession>
    <name>A0A914YCG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCG1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15159.t1">
        <property type="protein sequence ID" value="PSU_v2.g15159.t1"/>
        <property type="gene ID" value="PSU_v2.g15159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15159.t1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45243" checksum="7C14963FDF9A7F2B" modified="2023-02-22" version="1">MASDTSEKKYAAFIHCDNLENDIIVTAIDLKTLKQIRSYFEVIPAKDVKKFINDIPSKFGDFKSIILSLFGFQSKDFKNNFEFRNAVRAKLQLTNARYQFIKIGTMLLSVPLYASGINLNVSENVVTATLINSNFEILNFEFTGNGYLLSDTQSIPYDENDNVKNIREKLCSKYNPKELIINADMDDRKKFEKMNNAHFVTCSCYVLTEFTAKLMADYSKWMLDKSSVKTLMVPLIDNQYVFSKFLGDKQHDEGLVANDKQILPFAKTLLLPKSKCAYAVVCQDRYVQKPVILLVIQNTNGNIAVMDVSTFPEPSVERINQNEKYHGIKFTLEIDINNFPTFTFRPMILKGIKILPQTLDDKKLKTKVPVIGFFGNLSVICVSKNGGNYEFLKDWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD22</accession>
    <name>A0A914YD22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Wolframin</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17334.t1">
        <property type="protein sequence ID" value="PSU_v2.g17334.t1"/>
        <property type="gene ID" value="PSU_v2.g17334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045400">
        <property type="entry name" value="Wolframin_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026209">
        <property type="entry name" value="Wolframin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045461">
        <property type="entry name" value="Wolframin_OB_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098:SF3">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20053">
        <property type="entry name" value="WC-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19913">
        <property type="entry name" value="WCOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02060">
        <property type="entry name" value="WOLFFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin cysteine-rich" evidence="3">
        <location>
            <begin position="182"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin OB-fold" evidence="2">
        <location>
            <begin position="271"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17334.t1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44667" checksum="D688E1A8FC89D9C6" modified="2023-02-22" version="1">MGFLNCSVGIPSLAFAFVPFVYLIMAKLHCNSTKSIIRTIIPHIVCICWCDVAATMWLIGYPYFTLSGSVLTVALISLLVFPSYIGGILAAGVAFAQLRTAINLMTLVKIIITVLVLCVPFIASRIYNWAAKKWNIKVFATEYKRQWVFLSAYICTLLMAISFLYQNQSSFDASSDITNMTWSQFDRNCLPNGPNIIKNQIECSQLKGTAVNWKGSVMSVRIVGIDNSFETLLDYLPDAAGQFLRCFYDTDNNETDTASGMKVNECSLTIHNLYNFEIEVSGPYGERSLSANKGQVLLSASHNFYEVLKYLDEGDVIRFVGYFDQYPIFKYPPKLKLTQLECIHCKKLYNNKESKNLKFTSVNKMSGSRLWSRIFYSFKFMFNFLFSPLLTIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD50</accession>
    <name>A0A914YD50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoyl synthase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YD50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18150.t1">
        <property type="protein sequence ID" value="PSU_v2.g18150.t1"/>
        <property type="gene ID" value="PSU_v2.g18150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18150.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9778" checksum="C66E71025D04176C" modified="2023-02-22" version="1">MLGLGEEFEQIKATMRDLRAHDVDMITIGQYLQPTAHHHPVLKYWTPEDYKALEDYGYELGFSHVASGPMVRSSYHADVQAKGAGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDP0</accession>
    <name>A0A914YDP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDP0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18340.t1">
        <property type="protein sequence ID" value="PSU_v2.g18340.t1"/>
        <property type="gene ID" value="PSU_v2.g18340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18340.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14953" checksum="A7A979CC414C41FB" modified="2023-02-22" version="1">MSSSNNSNNNTDGNSGNNNQPTKKSGWRRLIAKFRRKPKPSSETTSPTLQTTQSAFDLPQESDGPGGGCVKKKKKDSSDDEVTVEANTSWKPKPVRKTRSMEGALSGKSTKKVRTSKRQRRKKKRPSKETIDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE28</accession>
    <name>A0A914YE28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17017.t1">
        <property type="protein sequence ID" value="PSU_v2.g17017.t1"/>
        <property type="gene ID" value="PSU_v2.g17017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17017.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25482" checksum="311B10B462E6D0E8" modified="2023-02-22" version="1">MPSSFKAGISSSYKKEANANIKDLINKFNGNSDPPKTSQDSRGSNKFDLDTENRSGAIKCRSIQRECIPLINDAIDGSKFVEKYEKEEFESTAVDFESAEEHEAKAQELREQAQETLEKNEMEFQQAHQAQTAARIASEIANAKTDAALEHQEIGQELLVEAGAKLIEAGAKLQEEAMETQMQLPFNVHQEGEIQQTTYVSTVGIEAAAAAHDIQTFREVEHLPETAHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFG4</accession>
    <name>A0A914YFG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19042.t1">
        <property type="protein sequence ID" value="PSU_v2.g19042.t1"/>
        <property type="gene ID" value="PSU_v2.g19042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19042.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38432" checksum="02275BCAA021FEB6" modified="2023-02-22" version="1">MSRTRKTKDSDTAEKENNSNVNLQPAGSKRKSFQAFFSKEEDAKPKVRKLIENLNLSDFKTLLSKSIEEQKQEKLVLLLTNSEKLRSTEVTGKTLNFGMRDINGITIEAVVFGNSDQLRLKSIVNSTSATDDVIMFQGWTWFINNSTFISSNMIQDKINVGSRTEISFASTTDLVTSCLKVFKLCDSLERLIVGRCFNIHETAWFVVAKRPKFFYQTYSGVLISDGEFFGIVAVEMSASGGLKTKFEFNPDTVFKIKNVNAKIFDVAHRNIGELELSYLQLNNVQKPCIFYVDEKTDIVEGEYDDIVFAKELNDIKYPEQAEEVPKTPLSELIKSLKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG07</accession>
    <name>A0A914YG07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium-transporting ATPase C chain</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g177.t1">
        <property type="protein sequence ID" value="PSU_v2.g177.t1"/>
        <property type="gene ID" value="PSU_v2.g177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE C CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042:SF2">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE KDPC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g177.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8732" checksum="002CF0CFE11D48A1" modified="2023-02-22" version="1">MLSQRRHRVLDPHISVANARLQAARIAKVRGMPLAQVQVLIDRYTSARQLGVLGEPRVQVLELNLALDMAKRAQPAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG35</accession>
    <name>A0A914YG35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17729.t1">
        <property type="protein sequence ID" value="PSU_v2.g17729.t1"/>
        <property type="gene ID" value="PSU_v2.g17729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17729.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12336" checksum="8F483B689D8FBE39" modified="2023-02-22" version="1">MAQSEDQWSSSHLGDETLLPAELNSDSIGGKLQTILSSDFKTSLEKAKSVSPLLETEIKEWELQFPNLLIQGYSIKGEESQPNYIHEQITTQRLSVARKLVLTTIFPEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGG5</accession>
    <name>A0A914YGG5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YGG5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17873.t1">
        <property type="protein sequence ID" value="PSU_v2.g17873.t1"/>
        <property type="gene ID" value="PSU_v2.g17873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF8">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17873.t1"/>
        </source>
    </evidence>
    <sequence length="595" mass="68402" checksum="10ECAB140716567B" modified="2023-02-22" version="1">MIDKIDTLSEASRRYHSSLNFLKRPKEVENSPVHNNYKLREVSSESDEEIADSVFEKVNDRPDYRRVSICKKGVEDDSLEIIEGETCEQKVAIGRYRNDVNKTGWGVLEVETFPGFPEQLQAFAAGVAEGHLTKLQIYYHWQNTVEQMCNNQKGYCKKLYKYIQQNLDWIHTKLVSTPESDLYWHHVNLTYTQLTGIHEGYRKTQTAEFVPNLSFLLNPILMIQLSGELIDLNKALNRTFDAAVDDPEPSKCSGFLKVTDGNKDLLFAHVSMSGYHTMNRVLKLYKFAYDKKTTPGHTMSFSGYPGALASADDYNLISSGLASIETTISVFHEELYEKVKPEGQLHCWVRSIVANRLAHNGSEWATIFAWYNSGTYNNQWTIVDYKLFKPGQALPQKDLLWISEQVPGYVGSRDMTWFLNKFTYWPSYNIPYLKSVSTKSGFDEKGNSLNWWRWGYSPRARIFHRDHNKVHDIDSLRALMRSNDYTHEEFSKCKCNPPYTAEAAISTRGDLNPINGTYEIPGMGHRNHGSLDYKGTSYELFKNLQLNVVGGPTFNPLPPFNWNTTNIVAPHFGQPTLWKFEPYTTQWEAKVEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGQ7</accession>
    <name>A0A914YGQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGQ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18511.t1">
        <property type="protein sequence ID" value="PSU_v2.g18511.t1"/>
        <property type="gene ID" value="PSU_v2.g18511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024858">
        <property type="entry name" value="GOLGA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881:SF46">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18511.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27037" checksum="6CFD4D2CCDC00E89" modified="2023-02-22" version="1">MNILDGHESCSDAASMQSSRASSVSDMVKINNHNNLNENQEVIYLKKALDEKDQTYRDVVQKLQTLQTHYAELHTAYNLANQTLQSSTSPEFAEQITRLQGALSVAIEEKTSYQSELRAANNKLLTFETENKALKEQIRTSTGSSNLHEAEKKKLNEEIDRLARQLKHATSELEKQRRESLILESKIRQVNQDRNDFSSRLKYIFNEKEELEKAVASMKHELQMKEIFIKQKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI15</accession>
    <name>A0A914YI15_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YI15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16960.t1">
        <property type="protein sequence ID" value="PSU_v2.g16960.t1"/>
        <property type="gene ID" value="PSU_v2.g16960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16960.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10648" checksum="477C6334DD197A41" modified="2023-02-22" version="1">MVWDLNEGKHLFTFAGNKVINALSFSPIRYWLSVAMGSSIKILDLETKSLINELNVNNDTYKSGAEVTSIAWSADGTRIFAGYTDNMIRIWGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI46</accession>
    <name>A0A914YI46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI46"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19159.t1">
        <property type="protein sequence ID" value="PSU_v2.g19159.t1"/>
        <property type="gene ID" value="PSU_v2.g19159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="4">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19159.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35562" checksum="6923F7862016321D" modified="2023-02-22" version="1">MREAVKRLGGDTAKVNPLSPVDLVIDHSVTVDRFGDDEAFEENVRLEMERNHERYVFLKWGKQAFSRFSDGEWIAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPDVVGFKLTGKLREGITATDLVLTVTQMLRKHGVVGKFVEFYGDGLDSLPLADRATIANMSPEYGATCGFFPIDAVTLDYMRLSGRSEDQVELVEKYAKAQGMWRNPGDEPIFTSTLELDMNDVEASLAGPKRPQDRVALPDVPKAFAASNELEVNATHKDRQPVDYVMNGHQYQLPDGAVVIAAITSCTNTSNPSVLMAAGLLAKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YII7</accession>
    <name>A0A914YII7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YII7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18638.t1">
        <property type="protein sequence ID" value="PSU_v2.g18638.t1"/>
        <property type="gene ID" value="PSU_v2.g18638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF110">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038011688" description="Amino acid transporter" evidence="10">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18638.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="21800" checksum="69ED9F66125792DA" modified="2023-02-22" version="1">MRGLLQAWVTALGTASSSATLPMTFRCLEENLGVDRRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVNLSLGQVVTVSLTATLASIGAASVPSAGLVTMLLVLTAVGLPVNDVSLIVAVDWLLDRFRTSINVIGDAFGAGIVDHYCKEQFAQHDLEHNRHLSNAYAHPEAAALLLKDKRLSNAKQHEGGGYNALSTEETPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIW0</accession>
    <name>A0A914YIW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIW0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20267.t1">
        <property type="protein sequence ID" value="PSU_v2.g20267.t1"/>
        <property type="gene ID" value="PSU_v2.g20267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20267.t1"/>
        </source>
    </evidence>
    <sequence length="659" mass="75683" checksum="3C850BB093D7430D" modified="2023-02-22" version="1">MKILRKIRYGMHVFMSDDVEVDKVDKGRKILEKNLKVDDKRGYINYIAIDTISPMEDIYEDKRESVSNFIMGEEVVDVADNPLSSLDFNIPPGNEETEQYSRVFYNGCCNSALKTVIGALKTRVAAHRNEVVLETCLPDVHLKVSRIQRAMTNCKCWQRPVTLLNRVQECNCVRFYPLQILGKHSHNLTVPITGGGVPGLFAKAGIDFDFVRNRLAPCTTFIEFLGVLEKVDLQPVTRSTHESGKNFVKNKILPFWREVRDEIASPVIMESTDETMKLENSSTAPIIAICWLDGDPNAVVQVDDASPNEEEDVVQVDDSFWEFPVSSPSFDNLSPGITDEQDWDVQQQHQSRSRFSINLSFSDDVESGRVEVQDTVCVESGRVDVHDNVGVEIVQRLSKHFQLVDREIIDTYKKISLVITKNYTHCGSEIERLLATRSMDVVAKVESLISECRVEIMRACKYGRHTVDEIIWKRNHVVEQSSALLHICILYRQRDAEIFDAFKQWLIAFEERFEEYQSHTMLFVKGQNEAHIEVITVPATTVPQSVHTGEISFGAKLIEIVKTEMDEMVGLRNRVLWEHDKPREEFEQVRRAKELENLSLRRLVSRINRPRYIPGQGWAGSSDAFEQFHEEQQAVQQFVERDVGVQQQVVHQIVHNYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIX6</accession>
    <name>A0A914YIX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIX6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19468.t1">
        <property type="protein sequence ID" value="PSU_v2.g19468.t1"/>
        <property type="gene ID" value="PSU_v2.g19468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19468.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22131" checksum="AF314813CA045E52" modified="2023-02-22" version="1">MLFKTEVDGLAYIRADLKSKVKIGKNEFTVVPEIIVNTNVNQKKSYAFHVQDEKGDFEIVKVSLDKGYPRVPYDEINKRFTHSDAGTFVFTILTDVEFEKTDKKENFVKIPCRLFVSSDFMKALKLYEYCEDYIILPYHENLKFKYYIKKVKEESVEVCIENPFEIEIGGDYEKGGSLGKKEDYKQQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ98</accession>
    <name>A0A914YJ98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJ98"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19388.t1">
        <property type="protein sequence ID" value="PSU_v2.g19388.t1"/>
        <property type="gene ID" value="PSU_v2.g19388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037240929" evidence="2">
        <location>
            <begin position="28"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19388.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23391" checksum="8EACC6BE40FDE030" modified="2023-02-22" version="1">MILYGIYRLFNLILYLLGLKDVQVCKSVNKLEEQKVLQKNGKITNDLFDNNHEVGQLQNICPGKENISSVKELEQLVVKQSLAEIDSSKVKELEAEVEKLTKKNNELDEIVKRLGEKDRNAENQAEQVLKDYEKVSDESSGTVAEIIANFFKSLNVNKLKEDITRYEISIDILINQLYAIEAAYNEREAEVKEEINALEQVQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJM7</accession>
    <name>A0A914YJM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19065.t1">
        <property type="protein sequence ID" value="PSU_v2.g19065.t1"/>
        <property type="gene ID" value="PSU_v2.g19065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19065.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7689" checksum="72B0865F57800BC2" modified="2023-02-22" version="1">MSGARKKAKLKVIILGDSVVGKTSLTNQYVNKRFSNQYKATIGADILTKDVVIDDRLVTMQVGMNLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK10</accession>
    <name>A0A914YK10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK10"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17644.t1">
        <property type="protein sequence ID" value="PSU_v2.g17644.t1"/>
        <property type="gene ID" value="PSU_v2.g17644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037180659" evidence="1">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17644.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16148" checksum="05E75BD95B41674A" modified="2023-02-22" version="1">MMVKLWLTGTLSVCPAGESHVASSLVPKIYKGGIERPDVTLSDQIMNADDFIVLCSKVFYLDLDFVTVNDGDGNPVSFKWLLEHQTPCDHFTYRFRTSFHNTSKADFKELWKIPHLCYYGTLYLVDVPKEFDIDSLLSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKL9</accession>
    <name>A0A914YKL9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3 14"/>
    <dbReference type="AlphaFoldDB" id="A0A914YKL9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17864.t1">
        <property type="protein sequence ID" value="PSU_v2.g17864.t1"/>
        <property type="gene ID" value="PSU_v2.g17864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF30">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="13">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17864.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17861" checksum="580B0F03CED974EA" modified="2023-02-22" version="1">MALKFIREHCDEITNDDDNSYDTRLFNDYIRKVKKAGVWAVGLVGGAPLETPNVKDGKVIGWHVTWNKERKFAIDMAGFAISLDLIKNTEGHFGTECKMGAGAPETCFLDSLKLELKDLEPFGFTQDKKRELLVWHTQSVAVKYDKRKIDLHGFIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL06</accession>
    <name>A0A914YL06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Polynucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YL06"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18006.t1">
        <property type="protein sequence ID" value="PSU_v2.g18006.t1"/>
        <property type="gene ID" value="PSU_v2.g18006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043633">
        <property type="term" value="P:polyadenylation-dependent RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3090.10:FF:000003">
        <property type="entry name" value="Poly(A) polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000035">
        <property type="entry name" value="Poly(A) polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00957">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010206">
        <property type="entry name" value="PolA_pol_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025866">
        <property type="entry name" value="PolyA_pol_arg_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052191">
        <property type="entry name" value="tRNA_ntf/polyA_polymerase_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01942">
        <property type="entry name" value="pcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008634">
        <property type="entry name" value="PRK11623.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43051">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43051:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12626">
        <property type="entry name" value="PolyA_pol_arg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="10">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="12">
        <location>
            <begin position="169"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Polymerase A arginine-rich C-terminal" evidence="11">
        <location>
            <begin position="287"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18006.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="48063" checksum="47773FBB039A8767" modified="2023-02-22" version="1">MYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNISDRTTSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDGVIRLIGNPETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLETAQKIAQESGLTYHDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLLEHPKFRAAYDLLALRAEVERNAELQRLVKWWGEFQVSAPPDQKGMLNELDEEPSPRRRTRRPRKRAPRREGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL70</accession>
    <name>A0A914YL70_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YL70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2029.t1">
        <property type="protein sequence ID" value="PSU_v2.g2029.t1"/>
        <property type="gene ID" value="PSU_v2.g2029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046620">
        <property type="term" value="P:regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21774">
        <property type="entry name" value="MobB_LATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF418">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WARTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="293"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2029.t1"/>
        </source>
    </evidence>
    <sequence length="560" mass="63748" checksum="0079BE99543EAFD1" modified="2023-02-22" version="1">MRTGGGGGGGTTTIISRSPIGAMISAPPSSTVITIERDTTPQQKPPIRRIEGGVPVIRTRVERPYLPSQQIISVVDNTPTSSSSFKQQQHQQLHRQIEKASHSIQSIIVDPDNSSSNNNSNNSSAAAHHSTVNYVDQLKATSRLTKERDSVLSLSDHASGGNVSPNRSSGFTSPAAGMLSSSDREPTPQPDVPKITRSSSPLPPSICRKLKTKTYEKFVKPCKPGMYQFFMEQHIDSIIRQYKERNDRALQLLNEMAAAQFPETMQEQFLKVLRQKESKYIRLKRQKMDKNMFDIIKYVGVGAFGKVALVRKKDTQQTYAMKILSKELIIQKKQSSHVKAERDILSEANSPWIVKLFFSFQDSRNVYFIMEFVPGGDMMQLLIVKGIFEEKLARFFIAELTCAIEHVHFLGFIHRDIKPDNILIDRNGHIKLTDFGLCTGLRWTHDKRRYVIYEEENPNVISHLREDSFSLPPETKEQTKIKLLEYRQHRKRDAAHSLVGTANYMAPEVIRKTGHTQNCDWWSIGVILYEMTFGRPPFMSQTENQAETQFKVSFIHFCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLT8</accession>
    <name>A0A914YLT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20329.t1">
        <property type="protein sequence ID" value="PSU_v2.g20329.t1"/>
        <property type="gene ID" value="PSU_v2.g20329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20329.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="9366" checksum="F190D5F3CFDD0182" modified="2023-02-22" version="1">MSIHQVITGALNSGENSFSIGCVDGVSFIACAVGADVAILAPNFDRVQIIPGNETDHGEIVSAVTCCGDSGKIAAVYGLQIRIFEPSQGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLW2</accession>
    <name>A0A914YLW2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YLW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21319.t1">
        <property type="protein sequence ID" value="PSU_v2.g21319.t1"/>
        <property type="gene ID" value="PSU_v2.g21319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="333"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21319.t1"/>
        </source>
    </evidence>
    <sequence length="600" mass="69039" checksum="EF5916651A2C69D6" modified="2023-02-22" version="1">MFKGDDKAFVEMNEFIDNEMVQALNYDEIKSFEDYRYISATEAHWRLSDFWMYRLSHSIDRLAVHLENEQSLYMGEDADDEEMQKAKNKDSKLMAFFKVNQEREKEIAKVKESVEKLKAEKKPVNHIKVPEKILYNKIGVNHVWDGKNAKWNPRQKTTKPKLCRLYNVNPKRTNCFYLRRLLMAVPGPTSFENLRTVDGILYPTNREACVALGLVINDKLYDDTLFEAINHTSPYQFRYLFARLLAHCDLGNPLELFDKFEDHLIKDLLKKWSKEDAKKVAWRKIVYSMINQDKHLSDYPELEAYMKEIGFENEDTIDLKALYEEGMAAYTVMNEKQKAIVDLVIEGLKNTVPQSCCIYVDGIGGSGKSYTFNTIRKLTMGKGFKVVIMAWSGIAASLYPMGRTCHNAFKLEFPFENDSNSGVNPSSPHGKMLQESDIIIWDEFPMAPKRALKVVDNKLREIMGKDVPFGGKIILCGGDFRQCAPIVENGTVEEIIGTSVCCSPLWKQFQKFQLTENVRALPHENEFKKMLVEIGEGRFGETPNEIKIPEECMSKGDIIDEIFGDCMEHYDPATVMKRAILATWNEDVDDLNEQVLDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM53</accession>
    <name>A0A914YM53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19997.t1">
        <property type="protein sequence ID" value="PSU_v2.g19997.t1"/>
        <property type="gene ID" value="PSU_v2.g19997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19997.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30866" checksum="A2B34B945AE2028D" modified="2023-02-22" version="1">MSTTQPSTTGLDATDLSSLFTYLIELCSSKANSDEQQSIAQVIRPLFTKSLESSPSFYRFLNPLASTPKASNAKKNVMKRQPTPSNKKVKKKTSKSPQRKRKDSAPEGSASRPSSAKERKQSDEGNVSMDNPPQPLMSQDEVILKLLKAIEFSQDELATIVLCSLLRGYAVACKDPVGQRRLRRLVRLDAANYCLRAMRPLMSEKNPSPLQILACDALSLALVHVAAKDRKITLKVRLSGMIPLFNRRIMEAERLWTSSTLLRLVCRCCLRSGLKIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM81</accession>
    <name>A0A914YM81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM81"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1843.t1">
        <property type="protein sequence ID" value="PSU_v2.g1843.t1"/>
        <property type="gene ID" value="PSU_v2.g1843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1843.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31214" checksum="6B0B3BC3E9A61494" modified="2023-02-22" version="1">MQIVETPESLPKKCNSIIRPIKTTSSKYNLDSIDECFREYISFSLSKSNPYSSAQPASTSTIKSQTKSIKSSSSRGYSESPINGEKTIKMTSSKPQPTKRKVESNFIDNIKKSKTEKSNYSVSSSFVSSKATPNQFVSSLSIDCKKPQKGSPASSSEVKPRQKPSPQRSSLTPAFSNSSLVKKRYKNYISSSLPKSKPYYSPQPASASTIKNRTKSIQLSSSRGYSESPRPISGGKTIRMTPLRPQQRCTSFKTRSPANGFPRCELLTDNGIKMIIRFPKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YND7</accession>
    <name>A0A914YND7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YND7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18848.t1">
        <property type="protein sequence ID" value="PSU_v2.g18848.t1"/>
        <property type="gene ID" value="PSU_v2.g18848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18848.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17889" checksum="DD5029C9EDFD576B" modified="2023-02-22" version="1">MTGPDHSVKVTDIWKGMEGIYEKKLARAIGVSNFNAEQIQRIHSVAKVPVHNNQIELHLYFNQQKLVEECKKLNVSVTAYAPIGSPGRKDIIVGKFACRFGASLNPLENEAVVRLTKKYGKTPAQILLRHLIQREISVIPKSTNEKRLKENFEVKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP99</accession>
    <name>A0A914YP99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20817.t1">
        <property type="protein sequence ID" value="PSU_v2.g20817.t1"/>
        <property type="gene ID" value="PSU_v2.g20817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20817.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11793" checksum="A203354482A4ACE0" modified="2023-02-22" version="1">MSLPPIASENLLQVPSERIPIVTEHPMRALHRFIQTNNNSLNNSSNLNDSIEENDSETESISSLPNAPIICTPGGSPMPSSRRFLEVNSMKARYPSSFHRPRSPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPC2</accession>
    <name>A0A914YPC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19203.t1">
        <property type="protein sequence ID" value="PSU_v2.g19203.t1"/>
        <property type="gene ID" value="PSU_v2.g19203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037918975" evidence="3">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19203.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19236" checksum="192E2D1B15473834" modified="2023-02-22" version="1">MLAECIGAVLLLLVPVVCSVSSNCFYLPHIALEGGTYDEFSATDIQQCCVECARTQCCLAYTYDGTKGRCFMKSAITSSYKTSEMTSGLKANSNNGQGCSLRNIRISGGTAQTIKLLRTEDCLQYCTSYGIFSWSPPLKDSQDRNGDCSCMSRISSIEYSFGSRSAIIPSVNNLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPK8</accession>
    <name>A0A914YPK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21567.t1">
        <property type="protein sequence ID" value="PSU_v2.g21567.t1"/>
        <property type="gene ID" value="PSU_v2.g21567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050906">
        <property type="entry name" value="Notch_signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044">
        <property type="entry name" value="NOTCH LIGAND FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044:SF417">
        <property type="entry name" value="WEARY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036919776" evidence="3">
        <location>
            <begin position="28"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21567.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38484" checksum="469E3F985E04868E" modified="2023-02-22" version="1">MKLFFKMHTKYFCIAFVLFITFELGHSQSLNDSNSDIYQTSDDEYNSGIVIDSVPVDDSTNNRSLRIKRKDSIASKVPPKYCANNGTYEYGRCRCKYPYTGPKCLDFACEHGLSVGARYDPESPIWDKRCLCDDDWSGDLCNIPIADQCNGRGQYINGHCRCLDYYFGSRCQYVGKCEHGKLIEGICKCEYGWEGDYCSKIVCHHGYTTPETNYTVCVCPPRHTGQYCDECLLIGPHILPYPNCTKEMVPTIAKMSREKAHGQIISRLLFIGVALAVLLLLLLGMWILRWGRKRNTEDGGSIKDERASPLPPNHVDLQLLVRQKPAAIRFKRQISTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ51</accession>
    <name>A0A914YQ51_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YQ51"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21158.t1">
        <property type="protein sequence ID" value="PSU_v2.g21158.t1"/>
        <property type="gene ID" value="PSU_v2.g21158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21158.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="39009" checksum="9782637151E91B2F" modified="2023-02-22" version="1">MYKEFYYDGDVEGQQKYHFDLNHGYETFDERLQRPLDEGLASICKYLLQKFSSTSSGITLREAVQYADFACFRGTLQKFAATFFETQRPKDRGWKFMIVKFQGVFFIQELETDARQEEKIKETAYEKLATYWGLKFERYILAENGKMPDSRSPVSTIVQTNAIFKLHFNPLPEIPKSITVFYSAEIDGISKEGKHMEVKTRNHRSVIHHRIMNWWLQCRLANIKKITFGMREDGIVKTLETCSIWKLENLHCRHPKRAYDFDIAMNSIHFFLHQIKSFYNNHLKMNEVLIIERKPMELNVQCSIQKANYSQIFSEDFLRFFGPKKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ89</accession>
    <name>A0A914YQ89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ89"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21200.t1">
        <property type="protein sequence ID" value="PSU_v2.g21200.t1"/>
        <property type="gene ID" value="PSU_v2.g21200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21200.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18904" checksum="11653F32B46CDFB1" modified="2023-02-22" version="1">MTNTSVDIMHDLLEGHFQRVIPMVFREAMANGVPLARINNAITAFQFSGPDSQNPPTTINLPANAPENGDNVKMGANEMSTLVKLLPLIFKFAGIQLNTPIWQMFLRLQRIIDIVWAHSIDEATTAMLDQLIQNYLRDFQTLGGKNTTIKGHLPLHYPRVIREMGPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ90</accession>
    <name>A0A914YQ90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2195.t1">
        <property type="protein sequence ID" value="PSU_v2.g2195.t1"/>
        <property type="gene ID" value="PSU_v2.g2195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037941100" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2195.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="7919" checksum="C6F414FD0E8C0DFC" modified="2023-02-22" version="1">MKLFYIILLCVAFFGSSAAFGFGGGGGGGCGCAPPPPPPCGGGCGGGGGGLALPSFPMPQFPSLGGGGGGGCGCAPPPPPCGGGCGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQB6</accession>
    <name>A0A914YQB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQB6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2371.t1">
        <property type="protein sequence ID" value="PSU_v2.g2371.t1"/>
        <property type="gene ID" value="PSU_v2.g2371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2371.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19946" checksum="4C17561790323A32" modified="2023-02-22" version="1">MIIFCVSSVILQKLRNNTKFDFHFEEDEFFKALFMKIEISRNVVVNPLTLHNYQKEIEKLRKHVMKKFSGDKSSENSSENDDSEVPPLNDEVPEIPPLNYEDAPEVPPLNGNEEYAVKMLEFEVEEKEKLDEIPAHFSKAEEFFQNNSGNSFKSFKIVTLLFIVFAFLFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRJ0</accession>
    <name>A0A914YRJ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71587"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>maleate(in) + 2-oxoglutarate(out) = maleate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71599"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>malonate(in) + 2-oxoglutarate(out) = malonate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71591"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate(in) + 2-oxoglutarate(out) = oxaloacetate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71603"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>succinate(in) + 2-oxoglutarate(out) = succinate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71595"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRJ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2626.t1">
        <property type="protein sequence ID" value="PSU_v2.g2626.t1"/>
        <property type="gene ID" value="PSU_v2.g2626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000013">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="118"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2626.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="34842" checksum="3A05403E40CBB73D" modified="2023-02-22" version="1">MTTTETIATKLESTLTSKAPSIPNAVKFAFGGIAGMGATLFVQPLDLVKNRMQLSGTTGKKEYTSSFHALRSIIAKEGIFAVYNGLSAGLARQASYTTTRLGVYTYLFERFSKPGESPSFALKAGLGMTAGAVGAFVGNPTEVALIRMTGDGRLPLEQRRNYKNVFDAVYRIFKEEGVSALWRGCGPTVGRAMVVNAAQLATYSQAKQAILASEYVKDGIFCHFLSSMISGLATTIASMPVDIVKTRIQNMRVIDGKPEYNGAFDVLSRVVKNEGVFALWKGFTPYYMRLGPHTVITFIILEQMNGAYYKYVYGVKGASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRK1</accession>
    <name>A0A914YRK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRK1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3387.t1">
        <property type="protein sequence ID" value="PSU_v2.g3387.t1"/>
        <property type="gene ID" value="PSU_v2.g3387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3387.t1"/>
        </source>
    </evidence>
    <sequence length="485" mass="55259" checksum="42F0364B980D35AE" modified="2023-02-22" version="1">MAANSDEVITIDDNNADDARLDEAVNNAVQIPLTLHSLNKVINREWIDDATIDSVIYKDVIQGHNDRLMISAVVWNQTRIESWGPDRRSPYRLPTMPRYSTTFTKAVISVNSNNSHWSLAILNKNTKICTYYCTMRGSLGPNLQKIKLFCRLLCGGEECEVVEAPTNSFLLQRDGYNCGPMICMLAFRILNNERLFFGTAEANSWRQQVYEFYSPFVANTYNLSNDRHDSDIKIIEDSEDATDKIKASITNCNRMTQNNGIQSDATIDVKKGMKRKIEVSEGPPTATKHPKMIGSVKNDEENMILLSDEKLNLENEVKESFISFCNRKGLKKNKASRRATFSQEEKSVKNEKARKSKKEHYKTLDEAKKAHIRNKSKNNAANRRSALSEVNKIAERNKVKHAMRNHRNPQSLIAAGGNEINDQMEAHYLGPMDQICSNENCKAKHFKSEKVQGKTTFYSCCQHGKTVFPPQKLYPESLKKLFDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS09</accession>
    <name>A0A914YS09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS09"/>
    <dbReference type="WBParaSite" id="PSU_v2.g353.t1">
        <property type="protein sequence ID" value="PSU_v2.g353.t1"/>
        <property type="gene ID" value="PSU_v2.g353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g353.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14590" checksum="5A9148B3CD87834D" modified="2023-02-22" version="1">MVGMVRAETICRACLVRRLHRADDVDDLEARLLAGDDALLAGDHDHRPRTQQRVSSAGGEVERTRAERGQAHARLAGQATIGGRHEHRRLFVAGDDQLDAGMAERLDHIEVLFAGDAENTLDAFVLKCGDEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSA1</accession>
    <name>A0A914YSA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSA1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20276.t1">
        <property type="protein sequence ID" value="PSU_v2.g20276.t1"/>
        <property type="gene ID" value="PSU_v2.g20276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053352">
        <property type="entry name" value="FMRFamide_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47323:SF4">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FRPR-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20276.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="25070" checksum="67AF9F365ED11F6A" modified="2023-02-22" version="1">MQTCSIYIMVLITMERWTAVCRPLQVRIWCTPRTSRYGLGVIVLFAVSYNLVRFWEYSMHHSTTGYVYQRHLRDFETHPYYMVGYYTGLYLLTHFLIPFGVIIVMNGHVCKSIIKLRRAREMLTRQQQREQSTTMMLLIVTLIFAISNTLPFLLNLAECFNPNLFMDESTQWYAYQLNDLSNLLVVFNSSTTFIIYLGFSEKYRQTATRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSH2</accession>
    <name>A0A914YSH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2961.t1">
        <property type="protein sequence ID" value="PSU_v2.g2961.t1"/>
        <property type="gene ID" value="PSU_v2.g2961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2961.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="18101" checksum="A997AD9F9F9D6141" modified="2023-02-22" version="1">MGDAFKKTYELAEKQAMKKQEMFPEDNFILRDTVNAYLVDVMPNVKFSSMKFKSLHFAVEKGYYLTSAELSQFFLYHDRCYRREESFKNTYELAETQSLKKQEMFPDENFDLATSINAYLVDVIPHVKFSTMSCDFLTKFVCMFFYMILSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSI2</accession>
    <name>A0A914YSI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20365.t1">
        <property type="protein sequence ID" value="PSU_v2.g20365.t1"/>
        <property type="gene ID" value="PSU_v2.g20365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20365.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19649" checksum="36F6EC5E3BA302CF" modified="2023-02-22" version="1">MEDNDDEIDLDEKDKSDDEEPVEDEEASDDSESIGEIDEEMNELENELFGESEEDNEGLDEDLEDDDGSNEDEDIKEDFEDENEPVFKEDIYGRKVDTKTGKVIEGTSAARAMEKLEELNKNSTELAEQRSKIAKTLRGSINRLNESTLIGAVKSLEELFSSNSHNGKDLKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT94</accession>
    <name>A0A914YT94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT94"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2885.t1">
        <property type="protein sequence ID" value="PSU_v2.g2885.t1"/>
        <property type="gene ID" value="PSU_v2.g2885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037746892" evidence="1">
        <location>
            <begin position="26"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2885.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24689" checksum="AA42B6F99A2D0E74" modified="2023-02-22" version="1">MQLLRIASVLFFLHICYHPRLYVSSAPIKDSFNSDISDNAEEEIQTHSNDEHDNAVTKIFNSTTFANITNSLLRSDSYNTTNAFDLSTKRSMPYVIWISMKSWEKYHTFLRETCRTIKEETPKFGGQDVLENGYFKWEENEFHRELRVLLFPETSNTLKPLVDNGMIDKLDKRFLQKPLESFCYRKEAKHTKEEAIADEKAKFEDIVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTS9</accession>
    <name>A0A914YTS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3558.t1">
        <property type="protein sequence ID" value="PSU_v2.g3558.t1"/>
        <property type="gene ID" value="PSU_v2.g3558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3558.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29546" checksum="7CAB9AF79763524E" modified="2023-02-22" version="1">MIEIFFGTIVQIIFLGICINFTLIFCTKKKPVEDLMARPKFTAPATTARTSTEVRKINNNNNGKPNVEHTISIKLDNNADDDDMQGPRESMSRDPMTELPGTQKPKVVIQEDFDPDKGAETPPSNLQWDPNKDTNKEKSSKKPIASPMAKDRSQSKRKRQRTIDLEATQEFKHSKEETDAPSKKPLSLKSARSGNLKRKSKSKPKNGNNNKSHRTAFSVRSIKTQGTTTCTRQGGRTAQSPNCISRNREDRTKEVESTQDDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTX9</accession>
    <name>A0A914YTX9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridoxal kinase</fullName>
            <ecNumber evidence="5">2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pyridoxine kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxal + ATP = pyridoxal 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57761"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25105"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25108"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16709"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:25109"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YTX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3448.t1">
        <property type="protein sequence ID" value="PSU_v2.g3448.t1"/>
        <property type="gene ID" value="PSU_v2.g3448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="15">
        <location>
            <begin position="113"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3448.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35129" checksum="B9357CB902C05F86" modified="2023-02-22" version="1">MKTVEERLKCERSNKRVLSIQSHVVSGYAGNKCSVFPLQLHGFEVDFINSVQFSQHTGHKVVRGQRLTKDDLDILYQGLKENGINKYSHILTGYCGDPSFLNRIAKIVSDLKALYKEDLLYVCDPVLGDGGEYYAPKELMPIYRDTILPLADIITPNIFELSELSGIQISNERECLNAISKIHSKCPNLSIIVVTSGLISTDNSQMYCYASKNLKNGNFEQCRFTIPLIRGQFVGTGDIFASLLIVWLDELKGNIKPAVNNVIASLQALLKRTSEAAFRFGAEKPTAFERELKMIESRFDLLVPNLEIESIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUZ5</accession>
    <name>A0A914YUZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21317.t1">
        <property type="protein sequence ID" value="PSU_v2.g21317.t1"/>
        <property type="gene ID" value="PSU_v2.g21317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21317.t1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46928" checksum="B4FBFEA21254C328" modified="2023-02-22" version="1">MGYALNSGTDINDVNGMMAAITSGTIPLQGLTVVTGEIQYVPVNKKAVIPQITNLHDFSYDEKNPRVWRHFNIGPGRELDSKSFEDALIFPRLKITATWEHSPDDSGYIFWMKTSNTASLGDIATKDGPAVEEENEEENEEVDPEEPGPYDPQLLWSCLSPGCEKQYMHKGDRDNHMIEGNHQLAPEQYSLEEYTFKVYKNILEGPHHARIANRKSLETDESTTDTQPKEGWALKAPKKGNRYTTDMRAFLDAELDLYRNNGNVKEIERKMAEVKSSDGRKRFVPEQRLTAQQIAAYYKRKKEKIQKRKGKGKQFTSEEEEAESDQIVREMNDETGEIEIEHEDDPMILSAEDEIRSCIEVQDKTQDESEQNIANLYEDEQELSMLFEQPPKKAANCPKKRKSKKNAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV82</accession>
    <name>A0A914YV82_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YV82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3572.t1">
        <property type="protein sequence ID" value="PSU_v2.g3572.t1"/>
        <property type="gene ID" value="PSU_v2.g3572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3572.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35389" checksum="F9D19CD7F5AD0F16" modified="2023-02-22" version="1">MFRFIYQRVNPHLRAFSIVARQNFTQKNARRNFAYLTTGGSTTLALSLFGSSSKEKVVKAGNENSPEMLMREADAFYDNYMIDNCWGVLRRFERTTNPEILWRIARILAEKAKITLNKEEKRTLFLEALEYAEKALKNEEAPGCFGAHKWYAIIINYVGEIEGTKSQIKKSYDMKVHLERALELNPRDATTWHILGVWHFTFADMSGVTRLAAKTIFGTPPSSTYEEALRHFEHAESLQPGFYKDNSFYLGETYDRLGKKEKALEFYKKAFYAPIISVDDKDAHEKALGRLKKYGFDEKKLIEGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVN5</accession>
    <name>A0A914YVN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g372.t1">
        <property type="protein sequence ID" value="PSU_v2.g372.t1"/>
        <property type="gene ID" value="PSU_v2.g372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000163">
        <property type="entry name" value="Pyridoxal phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF83">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g372.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13595" checksum="76CA4AEB6335FC18" modified="2023-02-22" version="1">MPSYQISGPNPNVIIPDAGPILAAVQTAANREALVVGKPNTPAYDYICRRWKINPSRTIMIGDRTNTDVKFGRDHGLRTMLVLSGCHQVEDILENQINEREDMIPDFYADCLGVLIPQRCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWF3</accession>
    <name>A0A914YWF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWF3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4887.t1">
        <property type="protein sequence ID" value="PSU_v2.g4887.t1"/>
        <property type="gene ID" value="PSU_v2.g4887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000019">
        <property type="entry name" value="DNA N6-methyl adenine demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4887.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34617" checksum="09C5F8D363F6AC7B" modified="2023-02-22" version="1">MADSFASSLPCACKGIRFCASCLDSERVKKLNSENVNHNFDGYQTYVFNPANQRCYLTPNISTNSSVTDIQKQSDWLQQQSSDVLSNIESFQINGLLILENFLNENEEDKLVKEIEITPWVLSQSGRRKQDYGPKVNFKHKKVKCDRFIGVPEYADELLKKMNEKSNGILDSYQPFELCNLEYEPSRLSAIELHQDDMWIWGNRLISLNLLSDSVMTYENSEIKKIVFVFMQRRYLLSMFDDARYKWKHGIFSHHIINRRIALTMREPAKAFQLGGELYEKYGKELIERGNIRIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXH7</accession>
    <name>A0A914YXH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXH7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2795.t1">
        <property type="protein sequence ID" value="PSU_v2.g2795.t1"/>
        <property type="gene ID" value="PSU_v2.g2795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037641441" evidence="2">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2795.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="18852" checksum="F169C75B66EAAF3D" modified="2023-02-22" version="1">MNYFALIIFICFYSTVSSLQCYNNSTESPEITCTDPYCFIILTITGRGNAASYAQLEGCGTVLYEDPLLKSLNLTCQDGIVQSVNTSLSNVPFKGFLYCCKTDLCNAKIPGIIIPTPISQTVTPFDNTNTPQFKSSSPTTITAVSSTVSSDGIIVVPSIQSLIFFVSILFIGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY02</accession>
    <name>A0A914YY02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YY02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4520.t1">
        <property type="protein sequence ID" value="PSU_v2.g4520.t1"/>
        <property type="gene ID" value="PSU_v2.g4520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4520.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="35920" checksum="88BA12E7344AD51B" modified="2023-02-22" version="1">MNDFSSNVTVMPEPLNPTASALKAVLIVGLFLLTLVSSMLAFVLKNYAVHRHTSTSTVIFSLVSCFGGGVFLGTCLLDLLPDSLECVEKAFAYLHRDASFPVAPFFIAAGFLFVLFIEQAIVYARESNWIGDSEIERLLGGHDDHQLPESPAAPEPPVPGEEDHDIHFDPDAHSSIRAILLVSALSLHAVFEGLSLGLINSASVLLQIFGALVIHKSVIGFSLGIRLVQSRLKNFTVIICCTIFAAQVLIGGFFGLGIIQFMNQSSKGTTHLVSGILQSIACGTFLYITSFEILPHELKQRGHRPLKFLMLILGFLGVALFVYLFPDSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYQ8</accession>
    <name>A0A914YYQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5087.t1">
        <property type="protein sequence ID" value="PSU_v2.g5087.t1"/>
        <property type="gene ID" value="PSU_v2.g5087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038047751" evidence="2">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5087.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23212" checksum="566B5E40189FE442" modified="2023-02-22" version="1">MMKSLFFIALFCSCFIEFSHQRYLLSRNDDVSIENDNGRVIVKRDLGDDFFDTIIEKGKSFFSDDDESNNDNKPASVSSVNHDSANDRLTDNKNERTSTIDRTSSSSSDGTSNAETSSHTRVTSTKSDDDSDSLIDEKTFKTILQKVISFASSSDSDNENQGNDNTHNTESGKGSSDSDTDDLTDKLGNILIREGIKIGIAELASSFLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ38</accession>
    <name>A0A914YZ38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ38"/>
    <dbReference type="WBParaSite" id="PSU_v2.g576.t1">
        <property type="protein sequence ID" value="PSU_v2.g576.t1"/>
        <property type="gene ID" value="PSU_v2.g576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g576.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="10794" checksum="ABF825E8573AF887" modified="2023-02-22" version="1">MDRPELPAGDPGQGGLHRVPGGDHAGLPGAGCAVRELVAAAGGDPDRADDPAVRTVRRVADRWRQQRVRAGRPGGADGPGVQERDPDRRIRQRAGDGRQGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ41</accession>
    <name>A0A914YZ41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ41"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5215.t1">
        <property type="protein sequence ID" value="PSU_v2.g5215.t1"/>
        <property type="gene ID" value="PSU_v2.g5215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5215.t1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47641" checksum="4DCF24927BA821E6" modified="2023-02-22" version="1">MQKLDVESSEVLPESLNLFSSKQVLVAHESSAHVLVLPSSQLGSLPIMYKYACGNNMIDLRECLLSTSFKIVKKQTVKNDDGTTVTKTVNIDKNDKVAFLNGFGATFIKNLKLSINGRMVYNSNDLYAFTAYFHQLLNLNNQNSNQLQAAGFYKDSDESQISGDGFDSRADLYKNDGQFDCISKIYADIMDCPRYLLSNQTLEIELTPNNNHFLLINNGDQKTDYHVQILDSKLFVKNINLIPQLSYQIEEKLNAGNCVKMPFDRHITKAFYINPGRYTYDSTLHFSFIPKIVFAALVPTKDFHGTPNSSPFKFSSSHIQSIRLSVNGRSVPSSEYTCNFTLKKYGRVFYDLIAAAPHALVNLKSYANHSTIFAFDMRNTKNPKYSELQRVGPTAISLEFNQQVEAGGLQLITLSIFENPLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0E8</accession>
    <name>A0A914Z0E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0E8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5825.t1">
        <property type="protein sequence ID" value="PSU_v2.g5825.t1"/>
        <property type="gene ID" value="PSU_v2.g5825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5825.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43354" checksum="7E2F2F2357F3B4C2" modified="2023-02-22" version="1">MEKYKISDDPDICDLMNEVADETLESCKHIPQCHAEQEATEGEAVSERDKVSEAEEACEFENASMSNHNGDEENEGVEEEKEMENHYFQNVTSEFVLFFQRLALEPNNEIDLDVMYRVMCGRSPCDKKLAYFCDRIEYQYMYIELENPLLTNLDFFDKVCDAAVIDEWTGYWTHDIAHAFHVSTIITKISDPVGIVILSTLIAMEMFHRYPGRAVMRGRCIYVTGEALKFFRTVLEDKVLQTELLQDINARYGREDITEIGDLLHYCMSLGLGWMSAGTHGKMLHNYIIKSFVFDEIPEHLNQFKTYQICQFVMNTVCGDSDGFAITEHFTLCSEENWKYLHSVCTEVDFQIRAFHTYINDRLVMLANEIKECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0F3</accession>
    <name>A0A914Z0F3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCM AAA-lid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0F3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5360.t1">
        <property type="protein sequence ID" value="PSU_v2.g5360.t1"/>
        <property type="gene ID" value="PSU_v2.g5360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM AAA-lid" evidence="1">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="MCM5 C-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5360.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17147" checksum="AFA728F702CC25C6" modified="2023-02-22" version="1">MRNPETHENHARSKKMPMIPITIRQLEAIIRMSEALAKMELQPFALERHVDEAIRLFRVSTLAAAESGELAGIEGFMSNSDQSTFNRIENQLRKRFAIGTYVSEDLIVNEFVKQAYEESMVKKVIGYCVRRGLMIYKYQRKMLYRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0H7</accession>
    <name>A0A914Z0H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0H7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5383.t1">
        <property type="protein sequence ID" value="PSU_v2.g5383.t1"/>
        <property type="gene ID" value="PSU_v2.g5383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5383.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18525" checksum="423926C2F178C0B1" modified="2023-02-22" version="1">MNLVKVIINNNDKKAIDGTRKKSIKQTCCSQFFDVKEMSSSFNSRIPIVATRRNRLPSITPSTFSIDESSVEYIDSSSDEEFYPQLNVQKIPQTLNFDEQKDIKANESGEKYSDKKYHGNVFKGFKNMLNKFMYVDVPTTDINKGSDNVDERSVCITWLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0Y1</accession>
    <name>A0A914Z0Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0Y1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6381.t1">
        <property type="protein sequence ID" value="PSU_v2.g6381.t1"/>
        <property type="gene ID" value="PSU_v2.g6381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF7">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6381.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18516" checksum="ED26AC0B6BC7D376" modified="2023-02-22" version="1">MVHIYIILDSPTTIFQPLSTVTGRVIVENLKPLNVQSIFLKVSGKASVKFFRSSGNHTVTYKKHENYIQKRLILWTKKCDEKLSIGSHAFRFKFQLPEKCLPQFNNKIGKIVYKLEAIVDIPWSLNKCKEILINVSPSLDLTKDITLLKPVTFVTQEPLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1J1</accession>
    <name>A0A914Z1J1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sterol carrier protein 2</fullName>
            <ecNumber evidence="10">2.3.1.155</ecNumber>
            <ecNumber evidence="11">2.3.1.16</ecNumber>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Acetyl-CoA C-myristoyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Non-specific lipid-transfer protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">SCP-2/3-oxoacyl-CoA thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">SCP-2/thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">SCP-chi</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Sterol carrier protein X</fullName>
        </alternativeName>
    </protein>
    <organism evidence="37 38">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="function">
        <text evidence="24">Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:47400"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:87695"/>
            <dbReference type="ChEBI" id="CHEBI:87698"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:40343"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:77081"/>
            <dbReference type="ChEBI" id="CHEBI:77084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:40344"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:62960"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="29">
            <dbReference type="Rhea" id="RHEA:21566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31111"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:62418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:31113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:16865"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57373"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58507"/>
            <dbReference type="EC" id="2.3.1.176"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:16867"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31183"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:31185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31091"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="31">
            <dbReference type="Rhea" id="RHEA:31093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:35279"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:71407"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="30">
            <dbReference type="Rhea" id="RHEA:35281"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:31205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31087"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:31089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:46344"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:86042"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:46346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:18161"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="EC" id="2.3.1.155"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:18163"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.155" evidence="10"/>
    <dbReference type="EC" id="2.3.1.16" evidence="11"/>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z1J1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6578.t1">
        <property type="protein sequence ID" value="PSU_v2.g6578.t1"/>
        <property type="gene ID" value="PSU_v2.g6578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050633">
        <property type="term" value="F:acetyl-CoA C-myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase C-terminal" evidence="36">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2" evidence="35">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="34">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00045994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6578.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="25910" checksum="03268F77E696F34C" modified="2023-02-22" version="1">MLHFWITYEAIGLCPIGKAGELIDRGDNTYGGKWVVNPSGGLISKGHPIGATGVAQIVELSNQLRGRCGKRQVPNCKVAMQHNIGIGGAVVVGLYKMADGGSSHHDNNNNTSSKIENGSGNGNESGSLQSDAIFKEIQARAESEKDLVKNVQASFRITVTDGKTTKAWTINLKKDPPFIGESSEKVDVEINVKDEDFVQMAAGKLKPDQAFMQGKMKLKGNIAKAMKLKSILDPSMLKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1N7</accession>
    <name>A0A914Z1N7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7064 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1N7"/>
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        <property type="protein sequence ID" value="PSU_v2.g6273.t1"/>
        <property type="gene ID" value="PSU_v2.g6273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055492">
        <property type="entry name" value="DUF7064"/>
    </dbReference>
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        <property type="entry name" value="EG:BACR7A4.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34717:SF1">
        <property type="entry name" value="EG:BACR7A4.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23212">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="256"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6273.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44697" checksum="308B5D9F5EB0BFC3" modified="2023-02-22" version="1">MKFVISRRQKKSKENQQYVKSNTKVNILDGQFGGDIRNIEEMEHKQSLPKGHPMAGDCVFFDASNANGWWLTIGLAQRTNNIINLFFILKVPGLGTFVNEELPKTSNVKSIPSETEYLTESGFRIFCIEPMRKWHISFNGFLVPAEFCQPNFKHIGSEPQPQETMQKVASSFELIWENHGEYFDFDVECSPEAIARSIATEPWSKELFEKLKSTHQTHYEQFGKLKGVFNVGEFQTPTEIVMTSMRDHTITKYRNWAQIRRYIMIIYHLEDGTCIHTSVISMPETVFTQLQFGYVITPELKKLPVDYIDLQLPYLGENKKFPKKFHYSFRAGDLNYDVNVESKDMVNFKMGETQACYIEENMCEFVANGQKGYGFAEVEYRIEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1V1</accession>
    <name>A0A914Z1V1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1V1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6679.t1">
        <property type="protein sequence ID" value="PSU_v2.g6679.t1"/>
        <property type="gene ID" value="PSU_v2.g6679"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00028">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6679.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17531" checksum="A96EEDF1A6425A84" modified="2023-02-22" version="1">MIKSLKLAKKDAEDALILWPSWWKAYVRLAEVCMDLEDFALSKALLEKAIILNPTYIKAMQQLKFFQSQIVPLQPHSSPEDEIEVARGKPGKKSRENNQNISSFFNASTPIGDDSILISDSEVDGGNLETSPNTIPQKTQIEETPKKSDEKAKKAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2B3</accession>
    <name>A0A914Z2B3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4 10"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z2B3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6036.t1">
        <property type="protein sequence ID" value="PSU_v2.g6036.t1"/>
        <property type="gene ID" value="PSU_v2.g6036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000001">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6036.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="25912" checksum="AD61055AEEFE603A" modified="2023-02-22" version="1">MDAFGTAHRAQASTHGIGKFADVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAQGHDVGKSLYEADLVDEAKRLLTTCNIPVPSDVRVATEFSETAPATLKSVNDVKADEQILDIGDASAQELAEILKNAKTILWNGPVGVFEFPNFRKGTEIVANAIADSEAFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEERAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2S7</accession>
    <name>A0A914Z2S7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C-terminal-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2S7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6652.t1">
        <property type="protein sequence ID" value="PSU_v2.g6652.t1"/>
        <property type="gene ID" value="PSU_v2.g6652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="13"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="108"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6652.t1"/>
        </source>
    </evidence>
    <sequence length="531" mass="56966" checksum="EA9F9DBA727CBD57" modified="2023-02-22" version="1">MKPLVALLDGRDCSVEMPLLKDIATVAFCDAQATSEIHEKVLNEAVAALMWNTIKLEQSDLEKFKALKLIICLGSDTGNVNVKAATDLGIAVCNTPGICIDEIADSTMSMILNLFRKTHWLSKMMENGKIANGIEQIRELSTGSKRIRDSVLGIIGLGQVGSAVVIRAKTFGFKIIFYDPFVSEGAEKVFGIERCDTLDALLKRSDCVSLHCSHNSKTSNILNEETIKKLKFGAFIVNTGRPELINETALVSALRTGHVKAAALDIQHILDTNCATQLAASGQIIQTARTSWLSEESAHELRVAAAKELRRALTGRIPQDLSCCINRDQLNTKNNDSSFNSNNHIGSSASSSTPNQTFNSLQGLAGFSADAYNGLSMPTSFASLPYTNPLLMNPQLLMSNPALGNFPFSGVNPASLAFGNAASRLLSQSPKSTQSNNKRSISGASTPAHNQITSANRSPSTSPNVPLANTSSQQNNDGDNGINVKHNNDVKDDDGEEAEENEITENATEAKKIKLDDDEINASVDGSEGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z441</accession>
    <name>A0A914Z441_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z441"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6774.t1">
        <property type="protein sequence ID" value="PSU_v2.g6774.t1"/>
        <property type="gene ID" value="PSU_v2.g6774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF10">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6774.t1"/>
        </source>
    </evidence>
    <sequence length="562" mass="61696" checksum="44B8D7B75F6426B6" modified="2023-02-22" version="1">MSIPHSAYHFDVSIGECIEFIFNGCGGNQNRFGTKDECLLGCGALAKCGKGLPLMDFAGNLKRCDGDRIPCPGGYECIGQGMNSVCCRKADRICGMSVDAGKVCGTVSETRYFYDGGANLCRPFAYLGCAGNENNFKSKGECLKFCAQQIYCLKGDPWPDRYAVSRIATCHTNKDCPNNYTCIQRNNRRACCPSTEFVCGTPFDTKNSCRRNGGDKQIGWTFNFKKGQCEKIDVAGCPDQLNDFATLEQCEDYCIGNCPDGSDPHINPFTGQPQMCSIKSNSGCPLGFECVRKSKFSAVCCKTSPTCPAPESLMFTSLDQGEAVRCVPGIESSCPDGYTCQEALNHEHICCTPSLDCPFGMKALREDFNHPHVCSPGVEGNCPKDGYYCIRADLGPLQPLKNLCCKPEKKCVLPYVNEKTQRPQKCFPGDQKCPTGTHCLEIGNEEKEKAKTIGLTFYCCYDVDIFACPNGEMPLTTPENKPQKCNLSDPKSCPVDYSCMTLLDDSFACCPIPDKQKLCKHPITKSDGNPISCGGEHDTQTCAYQKGKCKRTLDMNYHCCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4E5</accession>
    <name>A0A914Z4E5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4E5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7565.t1">
        <property type="protein sequence ID" value="PSU_v2.g7565.t1"/>
        <property type="gene ID" value="PSU_v2.g7565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7565.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25014" checksum="233A88E813127127" modified="2023-02-22" version="1">MKSLTKDKAATTTSGKPKKKRPSIFSFFSRKKTKTEPKSHSTLDDNISHGGSELNFDEVVVPKESAVIPTAVKSKKTFRAPLPPPEENKENVKDISKKRLSNASVPPKFSRQGSRRSSRRSSSRRKAASNSKTAIKIEETKSVISNDSAPNDPPPPIPPPLETSIDNEEPLPSPPSMTHLNSNRLKTVIKTETVYTLKKAVEITPSLLETDVDKSLFKKKKIKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4X1</accession>
    <name>A0A914Z4X1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4X1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7732.t1">
        <property type="protein sequence ID" value="PSU_v2.g7732.t1"/>
        <property type="gene ID" value="PSU_v2.g7732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038114481" description="Domain of unknown function DB domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7732.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13663" checksum="5041048F72FBC34A" modified="2023-02-22" version="1">MKTVLCFLSIFVGVVFAGDDAAFAACCKDKNVAETCQPICKYESTPDDVTKAFAEGQCNVETDGSPFYQCLENQKDNTKCCKAAGVGADASLDFCLDTCDGSKPHTYDPKYNGCSAYAQAIFDCGKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5Z7</accession>
    <name>A0A914Z5Z7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-glucose/GDP-mannose dehydrogenase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5Z7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7763.t1">
        <property type="protein sequence ID" value="PSU_v2.g7763.t1"/>
        <property type="gene ID" value="PSU_v2.g7763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7763.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14515" checksum="52C7C3041F4DAE7D" modified="2023-02-22" version="1">MAPDLKYVESVSRTIAEFAKSPKIVVEKSTVPVKAAQSIKQILKEAQSHNKDQYFQVLSNPEFLSEGTAMADLANPDRVLIGGENSEDGHKALAQLVAIYEQWVPRERIIETNTWSSELSKLVANAFLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6Z0</accession>
    <name>A0A914Z6Z0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6Z0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g846.t1">
        <property type="protein sequence ID" value="PSU_v2.g846.t1"/>
        <property type="gene ID" value="PSU_v2.g846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g846.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="23850" checksum="3C8AA1639037168E" modified="2023-02-22" version="1">MITIIGSINFDLITRSPKLPEPGETLTGRSFSTAAGGKGANQALAAARAGVPVRMVGAVGDDNFASQAVALLRADGVDLSRVATRGDATGIALITVEDSGENTIIVIPGANGLVTEDDVHAADLDGGYLLLQMEIPLPALEKAIAMSETSDTTCILNTAPWRDDAAALLPRADIIIANETEFDLASTHLELSGDDRLAKMIDFAEHYGRTVIPASAEDQTGRYSWCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8C9</accession>
    <name>A0A914Z8C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8C9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8587.t1">
        <property type="protein sequence ID" value="PSU_v2.g8587.t1"/>
        <property type="gene ID" value="PSU_v2.g8587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044714">
        <property type="entry name" value="AtSIBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46672">
        <property type="entry name" value="OS08G0495500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8587.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17891" checksum="2AF0422A87F95780" modified="2023-02-22" version="1">MKTEEDEKTVLACAKGVLQVELILHERLLTTASSYFVAMLNSGMKEAIDKKIEINDFSFEVVNATVVLLYISAVPQHFSFDQMKSILQFSDKYDIQLIKDLVQNYFIEKLSPANVRDLVNFVTTAVHAPKLHSKCSAYLIKCIKESKVDLDTIDKDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8F6</accession>
    <name>A0A914Z8F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8F6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8957.t1">
        <property type="protein sequence ID" value="PSU_v2.g8957.t1"/>
        <property type="gene ID" value="PSU_v2.g8957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="53"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8957.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20142" checksum="88B4A31B65E0EAF7" modified="2023-02-22" version="1">MQTGLWSSDDCFKQKPFVCEIPQSFAATTPNLSTTKSYPAYKNCSDGWSYFEATHSCYGTDNIGNNTYTWADAEKLCLNQSAHSVSLHTPEEAQFVSEILNFAVDFVWTGLYSDDNEVTWHWTDGSPVDYLPWYHDYPYLKAPSCAYIYDEHIFDNPCEINYFAICKRSATIYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9N7</accession>
    <name>A0A914Z9N7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DRBM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9N7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9385.t1">
        <property type="protein sequence ID" value="PSU_v2.g9385.t1"/>
        <property type="gene ID" value="PSU_v2.g9385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098964">
        <property type="term" value="P:anterograde dendritic transport of messenger ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19857">
        <property type="entry name" value="DSRM_STAU_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19860">
        <property type="entry name" value="DSRM_STAU_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19861">
        <property type="entry name" value="DSRM_STAU_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051740">
        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032478">
        <property type="entry name" value="Staufen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF3">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16482">
        <property type="entry name" value="Staufen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="62"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="401"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="521"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="830"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="935"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9385.t1"/>
        </source>
    </evidence>
    <sequence length="975" mass="107798" checksum="F4296688E5FAA047" modified="2023-02-22" version="1">MVPTNINHIKVLSTTTATSPEIQKPSLRITEEPWCGKHLNEQEVPLKNVYNYANKKDTNDKTPMCRVAELARYNKLKHEYILLDEDGPAHKKLFKVKLVLCDGEEFEGSGPSIKKAQQSAAEVAMEKSKLPRAPTKSKKQRKDSSNPTMLLNHVANQLGITVHYEDDIQQIKPKGRFPIPQQSQQRQQQQLQQQQQQQLRVSQEVRNVPFMPPPPYPLLRFPPPPYPPQGFFPTTFSPTTRCHLPPFQMMPPPTLSPSQMSAPRSLLSKDFIMSLPPPSLTSTAMNNGIKTTYKSKIKLSDGSEHCGEGSNKFDARCFAATKALTHLKPQLTELEAKMSKLKTKSAELSNSSNSSESSTTSSIDDNKENDNDGDGDVEVADVNDNTTTTMTTNGRKNRQKSVVSQIHEYALRLKMNVEFEVIQESGEPHKRKYVLRCQLSATGKEPIVADGEGTSKKSAKQEACKKMLETLQGIETDPLYLASMILLTNKKTAASLAPKEPKRKTIIKDLKMDPQYGHHINPISRLIQVMQSKKEPTFRLIKEQGQNRYKEFTFEITCRGITLTGAGPNKKLAKRAAAEAMLEQIGYVKPMPQPGKSLLKKKSIDSATSSSGMYNTSIDIGIFDPTELVAVPETAVTSSSSPPPPSATTAAAASEVTTPILSPRPSMNGLETFADVDNSLKDSSEASNDNNIINDGTPEIPKSPQRVTMSPIDDKEDSFQVEQIRKRRVTFSNQVSACPPPEDSNYPESSIAPLKSEVVIVSKLKKRGKDSKKSLTPEEKAAVAELCRDFFAYPLSENERKGYVSRDNDGGQFQIPTPENNQWQGPAIKTAKERLESLATSFKFTVAYSDFPKTETDSNDSQYFSLVSLGLEKPIVCHGSGNTNELAHNDAAFNALKDLTMIDGGIIISLPSQHQIMHQQQPQQQTLLTTLVLPHGIPPPPQLQQQQQPPQSSTSMNLIPPPSSGVLPVDLSLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA52</accession>
    <name>A0A914ZA52_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phlebovirus glycoprotein G2 fusion domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g8801.t1">
        <property type="protein sequence ID" value="PSU_v2.g8801.t1"/>
        <property type="gene ID" value="PSU_v2.g8801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009878">
        <property type="entry name" value="Phlebovirus_G2_fusion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07245">
        <property type="entry name" value="Phlebovirus_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Phlebovirus glycoprotein G2 fusion" evidence="2">
        <location>
            <begin position="162"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8801.t1"/>
        </source>
    </evidence>
    <sequence length="672" mass="75505" checksum="0B14A12186359611" modified="2023-02-22" version="1">MIDQNVTVTCWRKGVISGSKTQLCLGENFCDHILCIFCPEFVANFACISLIWWFFLIFCIPITVLALIELIYFMYKKKRGKRAALLRQLISFISNIRQCKAQIPEEVELTELQPLSNNEPDDLPETPSRDSRQAVPITYNSAIAISIISLCFCFSMADSATQVISYQAENRFCVRTVEGITRCEHNHVAHFTVKDKNLVEMIFQDEKSAPQATLTLKITPIATCIKGRSTFTRLVTIKEYSSQRCPGSGSCIDKICEETVANTSIPELTLVNDKPGVTRCASSCACWGCGCFICTESCTFYRYFAEPQDSLIYEEFFCRHWKFGADIELIQRTNHKTESFQFHLEEGMSEEYDHLKISLTAVRSSDIISFQSFLYDGTRLSLSDDASKEAMQLLKCSSAFDAQMMNCKLDEKTCNCSPAGDGVNCQCKNNQIIKDQLDVSFFPSESAQVKLNESRVFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFYILEDSVSDILVETKNFEVVTQIDYNSCHFLNSSVRGCANCNNGAFVFLQCQSDFGMSLATVTCDTFVFSVLCDANTHIVTLDLNSTTVFLNCILKCPANSESFNITGELHFVNDKSVSPEKKNATSQLSWYQAITSLFDNLLNCKTYLVIALIGILLIIVILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBD7</accession>
    <name>A0A914ZBD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9233.t1">
        <property type="protein sequence ID" value="PSU_v2.g9233.t1"/>
        <property type="gene ID" value="PSU_v2.g9233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037961964" evidence="1">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="178"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9233.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33207" checksum="61585F8A8DD30F0D" modified="2023-02-22" version="1">MIAFIFLFLILIKYSAAECPSNTTEWQSSCFSFFNISTGFADAELRCKKVGGHLAAIHDGFTNALLAQEALNNFHESTQVDFWIGATNLIKPPMWNWTDGSPFDFTDWNKGEPQNTSGANCAAISTVDGYWTAQDCFKPKPFACQVPSSVYYIPTTPSYPANANCSMGWFYFPPTHSCYGANAGGFVGNWNAAETYCEDSKAQLPSIHSVAEFEYLTSLLYIDWANVWTGIFSIDNGRSWKASDNTSADFEKFGPWCPGRPLTNITGERCVAVGSIAGIGCYYDYNSTDRSFHTVCKKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBS8</accession>
    <name>A0A914ZBS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9199.t1">
        <property type="protein sequence ID" value="PSU_v2.g9199.t1"/>
        <property type="gene ID" value="PSU_v2.g9199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9199.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21832" checksum="7AD65A552C77288C" modified="2023-02-22" version="1">MLSNKFHHTVKNGTGTKLITLFQKQHLQQQQQLRSGSSSTDAEIPSHRLPVHDGFLMDTRAKGEREILDPAWKPKVGGYTKSLRIEIIDRKDYAFIGQYLTWHFAKYCNIFECQQMTYDEAAPFFFNLLHPAIDKPFSFAAFEGDKLVGIRINTFHTADEFPEMYPRGLQVDNPKFIIEKDYGQVDVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCB8</accession>
    <name>A0A914ZCB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9368.t1">
        <property type="protein sequence ID" value="PSU_v2.g9368.t1"/>
        <property type="gene ID" value="PSU_v2.g9368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036711669" evidence="1">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9368.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11954" checksum="9D0F582CC9D9B39D" modified="2023-02-22" version="1">MASLLKFILILLIFIITIVNAALNVQKRQTYQYPEELRKYARIHPGTKIIHGTLGRYAPQEWPSWYTRTIFKWDGESRLSPYHPNDVRYAAYQRSRLSGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCQ8</accession>
    <name>A0A914ZCQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PB1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8044.t1">
        <property type="protein sequence ID" value="PSU_v2.g8044.t1"/>
        <property type="gene ID" value="PSU_v2.g8044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048208">
        <property type="term" value="P:COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033512">
        <property type="entry name" value="TFG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15335">
        <property type="entry name" value="PROTEIN TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15335:SF7">
        <property type="entry name" value="PROTEIN TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8044.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30810" checksum="4268F493FEA57795" modified="2023-02-22" version="1">MSGQITLKVKYGADIRKAVLPSAEINSFGAITNWIAETYNLNDSNNLLLKYMDGEGDLVTFTNDEDLHLALSTESLFYVHVFSNSEDTNAIVSQLLKEIDHLKHTMDNLKIMIEDNASYLSQGRYSRPSTPPNHKSESIATIQPSVHEEIDHNGVARIVSSEIKEQPRDDMSSSHHDENQHMENIPIDQHSSHSPHPNHEHQHQQQQHPPQFPPPQGGNNNNMQQQQLGGGPPPQQQNSGFAPPPPHGFPPFPTQNQQQPPPPQQQQQFLCHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCQ9</accession>
    <name>A0A914ZCQ9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZCQ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9481.t1">
        <property type="protein sequence ID" value="PSU_v2.g9481.t1"/>
        <property type="gene ID" value="PSU_v2.g9481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="8">
        <location>
            <begin position="122"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9481.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35878" checksum="924FBC1FD9E8CBC5" modified="2023-02-22" version="1">MHSLGKVGKIETDTLDTFFDSSWYYLRFLDPKNENEFANKSILQKYMPVDVYVGGVEHAAVHMFFARFVSYFLYDQGLVSCEEPFLDLVPQGIVRGRTFTDPATGRYVLEKEVEQSGDSFVDIQTGGLIESSFEKMSKSKHNGIDPLDIIQRDGVDLTRLQLLDAASPRANLDWGTSDLKGLKVWIDKISKSVNTYIQSRKDALSSASKEELPKDVETIYRESYNYFVRNTTMLLDVLRVHNTAIARLQGLTNSLRKVNPVHAGQSREFERCIHALVIMLQVFAPNTAAELWAALSQVEAIDKKLWDHSKDVSHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGE3</accession>
    <name>A0A914ZGE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g936.t1">
        <property type="protein sequence ID" value="PSU_v2.g936.t1"/>
        <property type="gene ID" value="PSU_v2.g936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g936.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17757" checksum="B76E711EAEF82AAB" modified="2023-02-22" version="1">MATVFQDAEVHAAAKAAAAHEFILAKSEGYDTVAGERGSQLSGGERQRLAIARAILKDAPILVLDEATSALDVETEGMVKQAIDDLSSDRTTFIIAHRLSTVRNADLVLFLDKGHIVESGSFNELAAKGGRFASLLRAGGLMAEQAELTDDIEENSNVTRFPSKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS30</accession>
    <name>A0A914XS30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncoordinated protein 79</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XS30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10087.t1">
        <property type="protein sequence ID" value="PSU_v2.g10087.t1"/>
        <property type="gene ID" value="PSU_v2.g10087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10087.t1"/>
        </source>
    </evidence>
    <sequence length="695" mass="78812" checksum="FC50EEEF1A34AA57" modified="2023-02-22" version="1">MKPSSSEVFHLQPTIVEPTIMVHEPHERSESSPAVSSITKTHYNASRRNKYKNRNKKKQIRAECLRLTCSFCNEVLETFDEETLSLCLISLSTFVHREPTMAAPLLFRILTSVARFVDSPQYPWHDTNIFVPGNSRSAAKQLIRVTLHQMSACSIALQLFDSKIENINSFWPTVSFSLMDFTELNPVALVQVLFEDIMETWPQKLGRIMHNLAAYVVTLPIDACLSNWGTVINLMESFFRRYHNLLVGDSNSRPAVTTELKSTVILMIHVMRVQNFATFKSSVSLVEAYSKWLTEVLHDCRVDLRDLLAICTSCNRALIRERDKQLLTRAIVNELIQSIKFKYELVESNYLTIVEFILQDFGEEISADFDQFNTGASEAIRPFLSDILEFIADLHVLSKLKKQTNSDRMGGDLKAGLAEVVALEMSRPSLRDSRPVMRFIPWLMSPPNVTQAVPGAFADSVTNVRILSWLLLGALHASHSCLPVPIDCSNNMADYIHFVLAGFADQSKVDSEHHSFPHISTHNLSSHSHTNNNNPNISQQSLQQSVVHMSALFHAFHLCQLWTVYCEKISTGGDDTSSKAIDKILDFWSRVTPAILQLLAHSKVLADMVNLHFVNTMQALQQCNSSILCQLYPMWQPILTAYHSQIPSQLRMKLDACENQPTIERQPLSPWLKKVRYKISQIELQTSAASPFYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSS3</accession>
    <name>A0A914XSS3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914XSS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11024.t1">
        <property type="protein sequence ID" value="PSU_v2.g11024.t1"/>
        <property type="gene ID" value="PSU_v2.g11024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01336">
        <property type="entry name" value="MDH_cytoplasmic_cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000002">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011274">
        <property type="entry name" value="Malate_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01758">
        <property type="entry name" value="MDH_euk_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="159"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="13"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11024.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="36177" checksum="38DAD014F0CE9B7E" modified="2023-02-22" version="1">MPSSAPLRVLVTGAAGQIGYAVVLQIAKGDVFGNDQPIVLVLLDIPPLAAALEGVKLELQDCALPTLHGVEAVTDEAAGFKDIDYAFLIGAMPRKEGMERKDLLAANVRIFKSQGQALANHSKPTVKVLVVGNPANTNALVAAKYAAGKIPEQNFSAMTRLDHNRAAAQIALKVGVPVGNVKNVTIWGNHSSTQFPDASHAKVVKDGNEIDAISAINDNSWVQGDFISTVQKRGGVIIEKRKLSSAMSAAKAACDHMRDWHFGTPSGQHVSMAIVSDGSYGVPKGLVYSFPVTVDGSSKQWKIVQGLKIDDFAQSKLNATTKELEEERDDALAACEESKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSX6</accession>
    <name>A0A914XSX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP synthase subunit e, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSX6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11072.t1">
        <property type="protein sequence ID" value="PSU_v2.g11072.t1"/>
        <property type="gene ID" value="PSU_v2.g11072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11072.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8836" checksum="8B87F1ED898E9D47" modified="2023-02-22" version="1">MSAALRSVWQQVVHTKRAYMNPHEDFGRANIFRAAIGTYIGAFLLFKWNSSRKAKALKNEKTTKKQAIAEDALARAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTQ3</accession>
    <name>A0A914XTQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10643.t1">
        <property type="protein sequence ID" value="PSU_v2.g10643.t1"/>
        <property type="gene ID" value="PSU_v2.g10643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10643.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14574" checksum="D98299D0DEDA0F37" modified="2023-02-22" version="1">MGASIEDDHGGSGGGEEKITKFEGPPSLEETMIVKKPLGIRIHKSTLRVTYIEPNAAAAGEAYLGDKIVAIDAQNIKDINELNQKLKEKSSTVAVRMERGAFSWCKNFGTTIEMLQLDKEVIKANGRAIDVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUU8</accession>
    <name>A0A914XUU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUU8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11020.t1">
        <property type="protein sequence ID" value="PSU_v2.g11020.t1"/>
        <property type="gene ID" value="PSU_v2.g11020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11020.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23616" checksum="D4DB2C1FD1467F27" modified="2023-02-22" version="1">MTLDSCSIKGNPIYQSCDCNIPQWLCAFANISGYCSTVAWFLVLLPQIFLNIKRRSTYGIANLSVTITAVGKTTDFMQNYLLIMPIQYLIMAFFSSTVAQISTLQVLWYWKKLPINETPDGPIENEHQISTQCNILRVIGFIFFSTELVIFIAALLIRTKYWWLISAPIATYTIIAAFYIYNRHWCPTPIRIVAEKEEPKGEISDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVW0</accession>
    <name>A0A914XVW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVW0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11109.t1">
        <property type="protein sequence ID" value="PSU_v2.g11109.t1"/>
        <property type="gene ID" value="PSU_v2.g11109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11109.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21957" checksum="2B0F5A291D4983D9" modified="2023-02-22" version="1">MATLSRDSLCNIGAVQIPRPKCAGFQFVPTRGRMGFYRSIKRDGHKYGIEIKNERGPRRPQLPDAGSWAPPSADQIIHETNNNNIGEKQHQSQHQHSPSEQSFSDLSSDSGSTKFSIAPLKKTPPPAPPLPIDAARLPPRPPRGGVPIFKKQPQHQFTQIQKIQIEKKEEPPVDYDINEDDTKQSFRRVRYKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYD2</accession>
    <name>A0A914XYD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYD2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12216.t1">
        <property type="protein sequence ID" value="PSU_v2.g12216.t1"/>
        <property type="gene ID" value="PSU_v2.g12216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="1">
        <location>
            <begin position="57"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12216.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26086" checksum="05E59B16C843134B" modified="2023-02-22" version="1">MFSKVRQRLKSSGRLPDLEVPVVKRIQLLSQIYDMTKSLLHDAREVIKMFDQEEGTLKNSTEAYADTLRVLGASVKANNPEYTIFLEKQAEIYDELGHLQRRLQYDLSVKVVTPLSGWIHADFARMNSEMKRMYEKKTDFDSISSEVARNPRDGGLIHQQDLCRREYERQMEITKLELLRLSGIRNEHAKILSQFALAWKDYTAAARKLFEQIDSAPSKMTSVKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYM6</accession>
    <name>A0A914XYM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RanBP2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10796.t1">
        <property type="protein sequence ID" value="PSU_v2.g10796.t1"/>
        <property type="gene ID" value="PSU_v2.g10796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000003">
        <property type="entry name" value="E3 SUMO-protein ligase RanBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10796.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13207" checksum="43741F12494412ED" modified="2023-02-22" version="1">MKRKVIKKLKQYQRKPLILILRPLLLKKSQTPVAKEQLPLPITNAAGSWDCSTCMVNNAASEEKCVCCETPKEGTAGNTAPQPVFKPTEFKPVPASGIVNTFCLLYLFYYCFSFVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYV7</accession>
    <name>A0A914XYV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XYV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11716.t1">
        <property type="protein sequence ID" value="PSU_v2.g11716.t1"/>
        <property type="gene ID" value="PSU_v2.g11716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11716.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17193" checksum="B2B6C74A218EB0D7" modified="2023-02-22" version="1">MMTRPFRKYAPSQTDCLLSGLVLFQGEIDKSEAQNSITKTNSLNPYGSSLIPFFDIQYITSYPKAKNRSAVLALNHSSFEKTLASILHQFDTMFRNKAYIKNFEKEDYFLDGLEPMIEARNMVEDLRKAYADPWIFCSGGRAPAAAKNNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ66</accession>
    <name>A0A914XZ66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12507.t1">
        <property type="protein sequence ID" value="PSU_v2.g12507.t1"/>
        <property type="gene ID" value="PSU_v2.g12507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12507.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26475" checksum="CA47ECF0CBDE2FAF" modified="2023-02-22" version="1">MENLGKLVVKAFTRLSGAEQSLEAAVHYYQMMALYFQDVSTPVGMLGKDLIYVSWNNGSMSYNFLKDDCKRYSPREVLHKINAFMVTNCQFLDLEAEITKENMIYAEAMKFFVAFETKFGSPKDVTELTNFNSIKLEIITNLCRMRMSTANKNIEQLHEFVNKPLKMFESPYDMIKEMKTRLDPVQWRDAFCYVTTVVENFSFKHQQSYASVRRVLKFLAQKKFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZQ3</accession>
    <name>A0A914XZQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12685.t1">
        <property type="protein sequence ID" value="PSU_v2.g12685.t1"/>
        <property type="gene ID" value="PSU_v2.g12685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12685.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20091" checksum="84035FEA5CECF7A6" modified="2023-02-22" version="1">MSKQTRFASGDEVIGCIPLQLDENHAKEIMALAEGVENFEDIDNFGTNISRFTLVVELYHYEPSLLDSILVKLLNSLVANIHFPDKSDIGFSHKSLLALILLKRLTTVRGYKTIIQFLPHEVFMLPKLLSILEYYVTKEKCNNLENEAINMLLVWFIIVCRNPFDFHSFAIVLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZR6</accession>
    <name>A0A914XZR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZR6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11132.t1">
        <property type="protein sequence ID" value="PSU_v2.g11132.t1"/>
        <property type="gene ID" value="PSU_v2.g11132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11132.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10470" checksum="364AD9FAD5F6C4B2" modified="2023-02-22" version="1">MLLYRFADKYEIKSIMDLVENDLIKIITPSNVVQLIHFSKNFNEAKLYQSCINFLLKCSEAHTSVLGIESLDDHFLAMRFLDSLRPVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZR7</accession>
    <name>A0A914XZR7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="16">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A914XZR7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12023.t1">
        <property type="protein sequence ID" value="PSU_v2.g12023.t1"/>
        <property type="gene ID" value="PSU_v2.g12023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000194">
        <property type="entry name" value="protein-tyrosine kinase 2-beta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="18">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="143"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12023.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31431" checksum="51D8B34DDC12099B" modified="2023-02-22" version="1">MAKGKKDDTKEGKEKKDGGTLTNEDDEVSITDHVRAEDYYHGLMPKVDIEPLLKKDGDFLLRKTDNKGQIVLAVSAFHNGRVCHFMVNQDTDNTFYIEEHHEKTVTDLIAWHIKTKTALSSETGAKIKTPIERPNWLLNHDSLKLKKKLGEGAFGEVYFSEFNGPTGKTVVAVKTMRDEASREARLKFMKEARLMRKFTHKHVVKIYGVAVHENPLLIIMEFCPGGSLLAYLRKNKEKLSNGTRLRFATEASDGLWYLERQKVRNFHSFYFNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y077</accession>
    <name>A0A914Y077_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y077"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1361.t1">
        <property type="protein sequence ID" value="PSU_v2.g1361.t1"/>
        <property type="gene ID" value="PSU_v2.g1361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037908295" evidence="3">
        <location>
            <begin position="19"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1361.t1"/>
        </source>
    </evidence>
    <sequence length="650" mass="73754" checksum="25927136E874BB13" modified="2023-02-22" version="1">MKMKLFLLFFVIIKFVGSEQNVADNYHGNLRQWTIKADGKMHIGLHLLKESVKLTFPKVTRFNELLSEIKLYSPNERGKCKDANSLNFNLVIAPKNDIHGEIKVISNRIVANLFETCDGGERPDHTAYASPLIDVNPVSLAIPGHLCYDNINTVPFQIYDKDKTKYFMELQVSGNFDCQPSYMELENIELPEFETNKLNESFAGHEEEYWWKRGNDEMLPDQISFDSEKNVKINLLNSTVSTPHFFRIGIEQPIPTFKFNFGAKCVGAVFEMYLNLKKDCHILIKLNQNGFTFSTPLNQNNNITGALSSLIFDGNQVFVKVASPLSINKYQTCQLSNPSDVPNDQFVLQMAPLENIGDCETAEIILSHSDVVDGIEVLIDRAKIVENTTENATENSTIPSSTDKSAEAKMSWWWYLIFGGIGLFIVVIAILIYIFVVRPRLQNQKKSKTPIVMIESVEDEDHRRITVDTKTAISPELKPQKVQPSKSVPPPINDSGKKLKDNTQIIVGAPAKIVTPKKSNDAKVMAKDATDKNDKDGDKNPTKSIENRTQKSVNPIKFDSNFVRSLLPASAFAAEKFYEDYPIKDDKIDLNKCPSDITITDDFWALFSSFLKADDITELERPNRKHGRQYQYQFIVRDLSKPQQWITVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y153</accession>
    <name>A0A914Y153_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y153"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11566.t1">
        <property type="protein sequence ID" value="PSU_v2.g11566.t1"/>
        <property type="gene ID" value="PSU_v2.g11566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036989143" evidence="2">
        <location>
            <begin position="19"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="84"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="581"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11566.t1"/>
        </source>
    </evidence>
    <sequence length="754" mass="83756" checksum="948B57072F78C734" modified="2023-02-22" version="1">MRLRGFLIFLILWTCGTFEIIEIIEEGSGGEVEIRTNENSFDNVTEADINPSISAIIDQTPLKVDNVKPKSADPKIEECLPKLDLIFLLDSSGSIEQIYHEHVRWALALVDTLPIEPDAVHVAAVQYAGFPLTEFSLGTYPKVDEIRQHLQQINFQSGITRTGYALRKAESELFLEDRGARKDATKVIILFTDGLSIDDPLKPSAQLREHKGVKIYVVSVGNDGFKSEMSRIAGEAEHVFGPEDLPQLRNALLNDAEKARACSQIGPTWLKKHKGTTLSPLNLLHKAVLPPLDFLGLLNDNDDEEEEKEEEGETKKNSKEKKTVSTSNSSLEKDNLTLLPQTKSTTDKSVEETTLTQIVTSAATVTALEVTTIASQTLTTSIEEGTSKTSVETRFTDTSLSTVSTKTEATTFESVDQVNEPDVKEKISKKPQESNSKAFAAQLNSIDESEDIIDVFDVPTEEHKKTTTVDPITTTTRHLTTPHSTSVVSSSTKPPATRSPTTKRVRTTLARRNLATTTEEPTESTTVFTRKRLTTTYPATIRIVTNLPRIVTTRRTPTFARISAFTQRVSFSHNKGPCPMDILFLVDSSGSVQKNYDTQKQYIKEIISEAELTEKTHRVSLLQFAGSHIQKTEWTFDAFSTSSELMTALNQVRFITGTTYIGAALDSALQLLENRRPNVPIIVILVSDGFSQDDATFPAERIRMIPNIQFYSLSVSELTNTNYLAQLVGDPKHVFVSSKATELKDLLIKKLRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1M8</accession>
    <name>A0A914Y1M8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1M8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13362.t1">
        <property type="protein sequence ID" value="PSU_v2.g13362.t1"/>
        <property type="gene ID" value="PSU_v2.g13362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13362.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15348" checksum="A141131B8638A873" modified="2023-02-22" version="1">MDVQCADCDQQVEGRAIFVENKIYHRSHFRCSECQLSIRHFYYLSAEEKPLCYSCKSFRHPLCKKCNTFVGETFIRAENQCYHLDCFVCSGCKKPFPGGEYVIHDSKPYDIDCFWDQTISSLNSIMPKSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1T4</accession>
    <name>A0A914Y1T4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">1-acylglycerol-3-phosphate O-acyltransferase ABHD5</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Abhydrolase domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37455"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74938"/>
            <dbReference type="ChEBI" id="CHEBI:74941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:37456"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37443"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74928"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:37444"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37131"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:37132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37143"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74551"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:37144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37147"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74552"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:37148"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:33187"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:64839"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:33188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37163"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74560"/>
            <dbReference type="ChEBI" id="CHEBI:74565"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:37164"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:19710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37451"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74937"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:37452"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y1T4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13194.t1">
        <property type="protein sequence ID" value="PSU_v2.g13194.t1"/>
        <property type="gene ID" value="PSU_v2.g13194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000019">
        <property type="entry name" value="1-acylglycerol-3-phosphate O-acyltransferase ABHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="25">
        <location>
            <begin position="132"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13194.t1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46830" checksum="D9182C5188AFC249" modified="2023-02-22" version="1">MYKIWSNIYSIKYLFINRNLQHRYLSLSCSAFKNPLDKTSTKLVPPPDPGLDIAIEEQAEHQVGIQTGVLHSKLLNYIGWDQFNIDKLIKAEKALLGNVKSKLKSRQIPIELWDSKIYTISLAEDSFPSKIPFVLLHGFGAGIGIWAANLDELAKGRSVHAIDLLGFGRSSRPSFSSNSTSTELEYIKSIEDWRKSMKIDKMIIVGHSFGGYLASSYALEHPENVRHLVLVDPWGMPERPKEMDHSTRKIPFWAKALSDVMSQFSPLTSLRIAGPYATSMIRRLRPDLGIRYNITDSDPNAIYEYIYQINAQKPTGEIAFKTMSLKYGWAKRPMLNRITKLNSKVPMSFLFGARSWISSSSGYKVKEERPQSYVDVNIISNAGHHVYADNQEEFNRVMSKICKTVESNQDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2F0</accession>
    <name>A0A914Y2F0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aromatic-L-amino-acid decarboxylase</fullName>
            <ecNumber evidence="8">4.1.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DOPA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.28" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y2F0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12958.t1">
        <property type="protein sequence ID" value="PSU_v2.g12958.t1"/>
        <property type="gene ID" value="PSU_v2.g12958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042423">
        <property type="term" value="P:catecholamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042427">
        <property type="term" value="P:serotonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF167">
        <property type="entry name" value="AROMATIC-L-AMINO-ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12958.t1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55783" checksum="E8B98BC9401E8EEA" modified="2023-02-22" version="1">MDSEAFRKHGKEMVDMVADYWDSLRDRQPLPDVKPGFIWDLVPDAPPESPEEWSKILADVEPIVLQNNTNWHHPHFFAYFSTACSYPAIMGDILSGGISSIGFTWKSSPSMTELEMIMTDWLAKSIGLPEHFLNSHPGPGAGIIQSTASDATFVAILSARARAVSSYKENNLIKSPVPQPEDDPVITFGNHDASIVSKLVAYCSDQAHSSVDKGIMLASVKMRKLKSIIGGPHKNYFIETETLESAIREDRARGLIPFIYIATVGTTNTCAVDPVRALGPICKRENIWLHVDAAYAGSFSLCPEYRYLVDGFEFVDSFNFNPHKAMQINFDCSPMWFKDAKEATTYFNVEAEYLRHEYQAVASDYRHLQIALGRRFRSLKIWFVLRALGIEKIQESLRQRVKLAEEFSDLISHDDNFEIIVPTHLGLVCFRYKGDNAINEKLVNTINDDRRIHLVPAKINGVFFLRLAICSTITNSKDIEFAYHVIKDLLPKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2R5</accession>
    <name>A0A914Y2R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2R5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13071.t1">
        <property type="protein sequence ID" value="PSU_v2.g13071.t1"/>
        <property type="gene ID" value="PSU_v2.g13071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058687">
        <property type="entry name" value="Ig_NPHP4_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029775">
        <property type="entry name" value="NPHP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058765">
        <property type="entry name" value="NPHP4_C2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31043">
        <property type="entry name" value="NEPHROCYSTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31043:SF3">
        <property type="entry name" value="NEPHROCYSTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26190">
        <property type="entry name" value="Ig_NPHP4_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26186">
        <property type="entry name" value="NPHP4_C2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NPHP4 C2-like" evidence="1">
        <location>
            <begin position="200"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="NPHP4 Ig-like" evidence="2">
        <location>
            <begin position="493"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13071.t1"/>
        </source>
    </evidence>
    <sequence length="679" mass="77636" checksum="6F3D9181D32FA94C" modified="2023-02-22" version="1">MLCWGAWCPYIDESFTISDTVTVPLIGGPRPNPDEILCFKNLLRLRQKENDPFNDGKPRISLKFNFAMVGSTDPQVLLKIPPRLDHFLHVPNERTISNLTPSPKPDIPVVQVQKGVLEDIEHSEIPLRHNPFDQSRITVIDTNKGYEAAELIPSQIRTDQHQKRRNNFEHENSTVLDHEAVPDIYLTKPSIFTRQINNYLTSISFPSILDRNGSSPTFVDPSGIQSLSIETELKDRLEMNEIIIQFIAILPLKNSYITTNSRISRYFFTLQFYRFQTVTTERLVAHPGTEWKSTLPIILKRIDENNKILDQNGNGFMFLCRQGSEGVQTALQCPVVQSSLPQEEAVTAFLYLKMANIGHPLNPQIDAFQSKNTSAIVSHRMRRLGEAQFNSLKTRARPLGAIHESALQRFLTAQKLDIHQRKEELFGSDNLERLKKWSDLKINTNNNNNNNGITKASLKRFVFQEELEAYKLVRNESKAAKLLKAVFAAITVSHSIRTQIGEIEFFEFCLQNTFAQRIKCHIDISDARIKPVTNAEEWKFFKSLKSLKTPLEKDLFEIENEKVFVSLAPMEAVYLPFKFDSSILAFKDEEEIVETKVIFKHSQTNEPISILDLSILISTNALSAQFRWFIDECSKVAKLITVPNYGRRISSVQCSDASVLLQLQNNQNGTQDLYFTVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2V7</accession>
    <name>A0A914Y2V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2V7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13779.t1">
        <property type="protein sequence ID" value="PSU_v2.g13779.t1"/>
        <property type="gene ID" value="PSU_v2.g13779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13779.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10266" checksum="A9E6A491629AACD1" modified="2023-02-22" version="1">MPRIHYHQTGASKLRNEPATTASQKSPTRRQTSKSPTRIQNYSPNRTKFREPVEMDFEDENHSPPKVRKLDESVASSSGTPPRQVCFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3I0</accession>
    <name>A0A914Y3I0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3I0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12317.t1">
        <property type="protein sequence ID" value="PSU_v2.g12317.t1"/>
        <property type="gene ID" value="PSU_v2.g12317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12317.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12114" checksum="CEEEDBF519BABE64" modified="2023-02-22" version="1">MVQEHAAPSDKLFRLFSIAKEFSDEPEKENGESSLFKYNAESMGLDLEYDADVASTAPEPASYETVFLSTHKAPCRSATFNLDGSLSAIGSADCSIKIYDIEKIIAREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3M6</accession>
    <name>A0A914Y3M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3M6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14794.t1">
        <property type="protein sequence ID" value="PSU_v2.g14794.t1"/>
        <property type="gene ID" value="PSU_v2.g14794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14794.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14468" checksum="E727E3B7E8C86CD3" modified="2023-02-22" version="1">MSKENSDPHIAESKPRFIPGVNERKFIHSRLYDRLRYFVRLPLANSFTRGITALCACIATTHAIAYFWKGPGHPLNRYRWNQMKKRGELSPELLEKERLLSDYIVDHWKNPRETLPKINTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Z6</accession>
    <name>A0A914Y3Z6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Z6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14918.t1">
        <property type="protein sequence ID" value="PSU_v2.g14918.t1"/>
        <property type="gene ID" value="PSU_v2.g14918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14918.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14336" checksum="B283F579E5E6C364" modified="2023-02-22" version="1">MTFYSASTNPVALTAQRPWTTLNDPAVDDLLQDCQERFCTFENASIFISTFNVNGKSPPEYTNDWLNFNTERMPDFIVIGLQEMDLALGTYVIESTIREEQWLRALKRSLPKIYHVVRQLLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4B9</accession>
    <name>A0A914Y4B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4B9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14285.t1">
        <property type="protein sequence ID" value="PSU_v2.g14285.t1"/>
        <property type="gene ID" value="PSU_v2.g14285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14285.t1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36148" checksum="B6C82574D443CDF9" modified="2023-02-22" version="1">MSLLGSPPRESLGSPPRESPEAFSVLGSALDDPANYDFGHSADKKSLLGPYDDFPKPKLGSSKLNIDFNDPSFEAMVQIQIQMANKLYFSEKKDETSSQNQPTYSQDIIAKQSSSKHGLDGPTSLSRYQQNDQPWFKLNSKPTQSVKIGWNKADYETTKPVSCNSESENVYNEALSSQRGSQSGYSGSYRNFSKKPHHNINNSGGFNAYGNRNQRFGISDRVYNRRGRGVGASSTFITEDLPEKFANGEDVPRKFGKSEESFRKFGKKRHFRSNNFGRGNYQKFSGSDRYRFSRPSPRSLSPACCRSELSSLGSRSRSRSPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4V9</accession>
    <name>A0A914Y4V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lecithin:cholesterol acyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4V9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15232.t2">
        <property type="protein sequence ID" value="PSU_v2.g15232.t2"/>
        <property type="gene ID" value="PSU_v2.g15232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15232.t2"/>
        </source>
    </evidence>
    <sequence length="216" mass="24825" checksum="2D0F610822B3F81D" modified="2023-02-22" version="1">MSKKGNYFAYIANTLVSWGYKRGKNLVGAPFDWRKSPLELLDFYATLKSLIQRVYYYNHETPVVILGHSMGNPVMNYFYHKYVDAEWKKQFIKSHISLAGAWGGSLQIVKLFASGYNMDYFRMNFFAITAEKNYSAHNVKEFFADIDYRVGLEQYNLANPTLILESPGVETHCIYGSKVNTPESFTWAKGYFPNYQPSITFGDGDGTVNIRSLKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Y4</accession>
    <name>A0A914Y4Y4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Y4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14297.t1">
        <property type="protein sequence ID" value="PSU_v2.g14297.t1"/>
        <property type="gene ID" value="PSU_v2.g14297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14297.t1"/>
        </source>
    </evidence>
    <sequence length="505" mass="57864" checksum="10EE32B5EF541B24" modified="2023-02-22" version="1">MEALSNLLSNRCSNRSLTVFLRSVLGCVSTAADKFRNNRQEDAHEFLTDMLSQLQREFNEAVRQLNGRRPEFLISSDPIRECFGYTLRRIFSCRKCHHETSVEEENTNFIVHISDERLKAEKFTFADILRDSMAEEIVEHVCDSCKASAAVMKHEFVKLPEHFIFVIRRYVYNLKKGHKHKLHAKVSMHKYLTFVTSEDIPTPQNHENQLKLAAIGESEASTSKGGRKAKNSLSRGIDNRWRDRKINSSKIGYLVEEIDGDEIIHKVFDDLFMWCRGNVQVKAKVTACKVLRDEPNENANNLLYALSGGNEYLYVKLREKIWNLLIKHADLYASMYGKSEKSFRDFIKIKAKKADLPATDLELHACAALFEAVINVKENGKWVAYIPKFVMLDDARKVVTSNHFHRKRFFLPVNVNYVASILHKKRARSYSLSSIVCHVGQTTEGGHYKCAVQTSAGTWSMCNDAVVTNCHEKTVLDKSSDSGYILFYSLCKERSPSPKRDNAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5B5</accession>
    <name>A0A914Y5B5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">BCS1-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5B5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12885.t1">
        <property type="protein sequence ID" value="PSU_v2.g12885.t1"/>
        <property type="gene ID" value="PSU_v2.g12885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="17">
        <location>
            <begin position="49"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="255"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12885.t1"/>
        </source>
    </evidence>
    <sequence length="452" mass="52253" checksum="C92D10926AFDED5D" modified="2023-02-22" version="1">MDIGNLFCDHQKMDVSNIKLNNITQEEVFHLIVEKLFANPIFSGGALLSIAGFFWYFVDWAWSIGNRLFRERYFTSLELTNENMTYRWVVDHINRNSKWETRNLSVESTLDENETGVSSLKHKFIPGLGNHYFYYKSRLVYFERTRDKRNVLVTDERGMNFNKRMETVTLSTYGGSIEFWRQFLDDASKECLDAMDKGLAIHTNRTDYWEENGNPKRKRAMETVILADGVSESVYNDVKSFLTCSLWYHDRGIPYRRGYLLYGPPGTGKSSFIAALASEFGYGIAMLSLTNKFLSDSDLHYLLNNAPKKCFIILEDIDAAFKNRDKKEENEENKNTVDSSITLSGLLNAIDGIASSEERILFMTTNYKEHLDSAIIRPGRIDFQVYLGLCTPEMTKKMFKRFFENVSEELINKFSEATSKFDKSFSPAELQKHLILYKDSPEAAIEHVNDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5K2</accession>
    <name>A0A914Y5K2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trafficking kinesin-binding protein C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5K2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14048.t1">
        <property type="protein sequence ID" value="PSU_v2.g14048.t1"/>
        <property type="gene ID" value="PSU_v2.g14048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022154">
        <property type="entry name" value="TRAK1/2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12448">
        <property type="entry name" value="Milton"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking kinesin-binding protein C-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14048.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11061" checksum="A31067421DF2412F" modified="2023-02-22" version="1">MDSDEEVTPRAAAATIQQQSTTTTTSLFEESPTSSSSTSESAEDMSEQSMLSKAESNDSLNKYTGPKLGEPGKPGTRDLEFSVRKLKLRKQVCFYFKHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6A1</accession>
    <name>A0A914Y6A1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6A1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14290.t1">
        <property type="protein sequence ID" value="PSU_v2.g14290.t1"/>
        <property type="gene ID" value="PSU_v2.g14290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00256">
        <property type="entry name" value="VATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000067">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="7">
        <location>
            <begin position="338"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14290.t1"/>
        </source>
    </evidence>
    <sequence length="472" mass="54485" checksum="37CE927291658C74" modified="2023-02-22" version="1">MAARDVSPHQIASVDMINATSKLQIEAADVRNNTTNKPNWTSYLRSQLIPQDEYNFISSYEAAKDRHERDEVLNRDPNQAAHAMISLVTDVAKDQIIRYVLTLFDDMLQEDKSRVDIFHAYARKQKRTIWSWFQGTLTRQDAFIVNQMSSIFAKLACFGTTLMEEKELSHYFGFLLDQLKSPNNEYINTTARCLQMMLRVDEYRVQFVKGDGIASLLSALNGKANFQLQYQLIFCLWSLSFNPEIASKIQQSGAIQVLGDILSECSKEKVIRIIFATFRNILEKIDDRDIQKLSALQMVQCKTTKTLELMDAKKFDDTDLQEDIEFLSEKLHASVQDLSSFDEYCTEVRSGRLQWSPVHKSDKFWRENAQRLNEKNFELLKILIKLLENSQDILVLCVAAHDIGEYVRHYPRGKNIIEQFQGKQAVMRLLSAEDPNVRYHALLAVQKLMVHNWEYLGKQIESEKTGDIVAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6E8</accession>
    <name>A0A914Y6E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6E8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15024.t1">
        <property type="protein sequence ID" value="PSU_v2.g15024.t1"/>
        <property type="gene ID" value="PSU_v2.g15024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15024.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9289" checksum="C723546C38C81278" modified="2023-02-22" version="1">MDARIQAEVDLLKDEVETKFCQMLDQNPDLIDYHFDVEIKKKEEKKCQNLKRVGAMKSENERQIEVLKIENAVVYFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6P0</accession>
    <name>A0A914Y6P0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6P0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15866.t1">
        <property type="protein sequence ID" value="PSU_v2.g15866.t1"/>
        <property type="gene ID" value="PSU_v2.g15866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15866.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33623" checksum="BA0A683605BD1324" modified="2023-02-22" version="1">MPKQMAKKFILEKGSDYLDIERNSSDDRDNESIPDSNSQHRPTNIEISPIDFGAPDNTIFVSHINPLFDKLKVLRYQAKDVMDNIEDLEIYMRSAADIQEENQKLKRELQRAKEEINLLKGRGGTSYNAKMPMTEIKAPRSRGNKISLETSYSKPSSIVCRTRLGTVQTEAWIFTFSDETTVTYRASDYILNEFISTLVFENCKHDIVRFSVQAIADFLRKPEFQHTVWTIATTGKIRGTMCQLPNAFIHDVVYIANVGFGADPDRSYWTENDYQNFTKALNNTTFTLRDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y760</accession>
    <name>A0A914Y760_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y760"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15109.t1">
        <property type="protein sequence ID" value="PSU_v2.g15109.t1"/>
        <property type="gene ID" value="PSU_v2.g15109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15109.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12878" checksum="902DCA99252BDBBB" modified="2023-02-22" version="1">MVKSSNTDPLLNDDFNARQFQTDLKGYLHSALQVDRDFTAEDYAALNPSSLRSIKYAMDFIKNPRKMCHEIAAHVQKMVEIIRWHKMNAASKNFYFQGFQKPLFKDFIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7H9</accession>
    <name>A0A914Y7H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7H9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16161.t1">
        <property type="protein sequence ID" value="PSU_v2.g16161.t1"/>
        <property type="gene ID" value="PSU_v2.g16161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050612">
        <property type="entry name" value="Prok_Mopterin_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43742:SF5">
        <property type="entry name" value="BIOTIN SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43742">
        <property type="entry name" value="TRIMETHYLAMINE-N-OXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin oxidoreductase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16161.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22793" checksum="D743CCBD58CFF544" modified="2023-02-22" version="1">MENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHRQHKRIREVYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFAINGVGGTAHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7Q5</accession>
    <name>A0A914Y7Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7Q5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14779.t1">
        <property type="protein sequence ID" value="PSU_v2.g14779.t1"/>
        <property type="gene ID" value="PSU_v2.g14779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14779.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9800" checksum="DB83E288579573D8" modified="2023-02-22" version="1">MAEWCRALILRPEPRSIILCFLLAFASMAIVQSQFVYTPYVYSSYVPYYGWVWGSNKNGGADAPMPPPPSSNGGGPAPMGPSFTNNAPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7V3</accession>
    <name>A0A914Y7V3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Solute-binding protein family 3/N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7V3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15534.t1">
        <property type="protein sequence ID" value="PSU_v2.g15534.t1"/>
        <property type="gene ID" value="PSU_v2.g15534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35936:SF13">
        <property type="entry name" value="HISTIDINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35936">
        <property type="entry name" value="MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15534.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15131" checksum="B40A91C8020F5345" modified="2023-02-22" version="1">MYPTVESLKGKRVGVLQGTTQETFGNEHWAPKGIEIVSYQGQDNIYSDLTAGRIDAAFQDEVAASEGFLKQPVGKDYKFGGPSVKDEKLFGVGTGMGLRKEDNELREALNKAFAEMRADGTYEKLAKKYFDFDVYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8C0</accession>
    <name>A0A914Y8C0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8C0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g150.t1">
        <property type="protein sequence ID" value="PSU_v2.g150.t1"/>
        <property type="gene ID" value="PSU_v2.g150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g150.t1"/>
        </source>
    </evidence>
    <sequence length="458" mass="51972" checksum="7EE68C7870C4806D" modified="2023-02-22" version="1">MLAHFNLETFFKFEISANFAEPDGTTPLLVYLSPNPEFAHFPPQNDITDVKVLALRGRRIFEPALSFSMALNEIYDGTAENSSSWQILNLDPANLEEFDYFTFFKQLFADQNSIKIDKDFKFVVKSPKYVQKLVKLLEKTSAETIKALIAANLRKSIKSDFDDCVKVVEKYTPLAATIVYLSSQNSTEIQQLREITLKMFEVLTDKVQTVIKPYLSNQAQKDIAKERLAKVGLSTEEPEWMQLSDAKKRFEKDYDSFELQTANPSSIVALLRFRRFGIVKQLLRLTDKNEALRNANFEFISQSTTKIGYSQIGNWINIPIAAIMRLHYSNEASFILEISNNLLKIVVPEGFRWSAYGTQRITPTHDRIPSDIIGQHQCFTVHGIANKSLTLPLALEAAYQTLATIDKSPFAETNLLWDLTHVITSKSFELSQTVLAAGFLENHGVHACEAKNVLPCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y918</accession>
    <name>A0A914Y918_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y918"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1594.t1">
        <property type="protein sequence ID" value="PSU_v2.g1594.t1"/>
        <property type="gene ID" value="PSU_v2.g1594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1594.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25162" checksum="A52FCEE0B350C7A4" modified="2023-02-22" version="1">MSTPRRSPGRKVTITNVWKDNLEYEFSRIRNILNDYPYIAFDTEFPGVVATPIGAFKSKEEFQYNQIACNVNMLKLIQVGFCLTNSQGELPPDGDIWQFNIKFSIDDDMYAVESVDLLKRSGIDFARLPNDGIKIEDFGSLLTTSGLVVNKKITWLTFHSCFDFGYLIKTVIGRSLPTSEKTFFEYHKVLFPRSYDVKMLMKVPKIQAVKLRGGLQDVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y992</accession>
    <name>A0A914Y992_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y992"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15850.t1">
        <property type="protein sequence ID" value="PSU_v2.g15850.t1"/>
        <property type="gene ID" value="PSU_v2.g15850"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g18465.t1">
        <property type="protein sequence ID" value="PSU_v2.g18465.t1"/>
        <property type="gene ID" value="PSU_v2.g18465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15850.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18465.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10988" checksum="F8ABDDDE410E9452" modified="2023-02-22" version="1">MSFAIVSIAIDRVRTVYRLMHIEKCGKVPGNSASQLVFVKRLIIATYIASAILSLPQFFAWKVIKGENFSQCTTVWHFERANNYQQNPNDTEMVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9C8</accession>
    <name>A0A914Y9C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9C8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15368.t1">
        <property type="protein sequence ID" value="PSU_v2.g15368.t1"/>
        <property type="gene ID" value="PSU_v2.g15368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15368.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38664" checksum="3105719B73A26990" modified="2023-02-22" version="1">MAVVKEQLTHFSPGSKFGQWRIIEKVEGEDPEGAVYKVSNKHGFFALKIEKLDVKFSYVIHEIDVLTALTQFGARHIRNIEESGQTDSFSFVVLTPVGKNLEDLRNEAPKKRFTLGTAISVGIQCLEALEDLHAIGYLFRDIKPSNFAIGASEYSEHRKLYATDFSMAKKFTEYGTPRSVGARFNINTRYAPLACHEKQKLRCIDEVESWFYMLVEWTRGKLPWKHLDNESAGAWKKRCRKALWYDQLLFGCPWEFIDIWRIIKRSKDPDKPDYQKIYVLLIHAMVKSKKLQYPYDWEVWEEKRILKEQKKNKKQSESVKAVAVCFFARFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9M6</accession>
    <name>A0A914Y9M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9M6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15469.t1">
        <property type="protein sequence ID" value="PSU_v2.g15469.t1"/>
        <property type="gene ID" value="PSU_v2.g15469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15469.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31268" checksum="278D62A427560250" modified="2023-02-22" version="1">MVEMMYRSLIKGKVPDVPQLIKDIRSQRSFAVQTEDQYLYCYYAILQLLHIKKVVPSHFVRHFIREYENYLKLLNDVGGRNLPMQATSLPQPCANCSKVAAHMNDAKAADSPPSESKMDTKKGAKDDSNKKMKEDTNREEKHVERKSNSRKKDDSKRESASKREKKHVDVGSKKEKKRKSNVLKQLKTQKEKKEKKEKREGKVKTSGEPNGGTPQQASPVEPQQIPHPTPDVPNQNGNPNEDLKPAETPVQNQNAFNDNNNNNNQQMVSSFVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA17</accession>
    <name>A0A914YA17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA17"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16125.t1">
        <property type="protein sequence ID" value="PSU_v2.g16125.t1"/>
        <property type="gene ID" value="PSU_v2.g16125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16125.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15676" checksum="F40E94151B15105F" modified="2023-02-22" version="1">MHHEGDVAPINEVEEDEKANVTDGESVVGSDNEEDESEGGNKDKEVTIDDIQSKGEEASDEELTEIGSTCSGLTDMSGFSDLEMDFPDQEGTVDAGVDEDEKKPLNLLGKKVKLAFILLKHAKVVVCRQQTVVNDLVVNVLERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAD3</accession>
    <name>A0A914YAD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAD3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14471.t1">
        <property type="protein sequence ID" value="PSU_v2.g14471.t1"/>
        <property type="gene ID" value="PSU_v2.g14471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000079">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF6">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14471.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14141" checksum="F7B77CAE97D8B3AE" modified="2023-02-22" version="1">MQGNRASIVALTFEEVERIPELKENPFRRRICEVFSEDGCGNLTFDDFLDMFSVFSEMAPLPLKLKYAFRIYDFDGDDYLGHDDLSKMIRSLTRDELTDEEVEFIIERVSFINKYISDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAM0</accession>
    <name>A0A914YAM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAM0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16480.t1">
        <property type="protein sequence ID" value="PSU_v2.g16480.t1"/>
        <property type="gene ID" value="PSU_v2.g16480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41349">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41349:SF1">
        <property type="entry name" value="PROTEIN CBG08683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16480.t1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39176" checksum="F46226810088270F" modified="2023-02-22" version="1">MYCNIEYFPKLEKYETKNGTHLRIMSFNTWIFGEHVNDGLNKIAKHIKLVEPDIVALQEVQTKEAFEKLLEILGPKWSGTTSPSTTNSNVAIATIHKLRGAEFILDTTKKINLIEPKKIIASTKTGFGLNIHLEESNEIISFWCLHLDWQSYGPYAANNKLVTKIEQIMNGEHPKTQNGRGDEIIELLKLPEFQEAVRNSDQNALIVCGDFNSPSHLDWKEDTKHLHGDWIVPWPATYLLESKAGLIDSFREINPDPLKTPGITWSTVHQASGYEWDYSIPEPLDRIDFIMYKSPKYKPVKSLTYFGTEPIQQMPNHQNNDYPSDHFSVITDFVLKYPDQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB26</accession>
    <name>A0A914YB26_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YB26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17414.t1">
        <property type="protein sequence ID" value="PSU_v2.g17414.t1"/>
        <property type="gene ID" value="PSU_v2.g17414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17414.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11919" checksum="C7ACAE44C0BACD75" modified="2023-02-22" version="1">MLHYSGVQFEDERLNFDTWDTVKQTSPYKTLPILTINGQQQIGQSMTINRYLAKRYKLNGKTEMEDVNINCIAEYFREMMEKARPFIRYMNRGIGEGTKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBM8</accession>
    <name>A0A914YBM8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16688.t1">
        <property type="protein sequence ID" value="PSU_v2.g16688.t1"/>
        <property type="gene ID" value="PSU_v2.g16688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="6">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="7">
        <location>
            <begin position="192"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16688.t1"/>
        </source>
    </evidence>
    <sequence length="496" mass="55797" checksum="FFCE29F1FF8DF740" modified="2023-02-22" version="1">MLSRLAFSRSYSVVARSPSFITSSPKEKVSRLSNGIRVATEGIPAKYCTVGVAIKSGCRYEINYPLGTTHMIEKLAFSSTQNYGREDLLKIMEDYGALIDCQSTRDTFLYAASCRTDGLDKIVPVIADTVLRPGFYPEDIEVTKEIISHENDFYAKNPECEPLLLDWIHTAAYQGNTLGLSRYCRTQDAEQISQSHLFSYISQYHDPSRMVVAGVGIDHDHLVTLVDKYFNLENAAWKMDPSLLLSHLPPIDKSVAQYTGGEYRCVRDLSKMALGPRGYPNLAHFVLGFESVGLNHPDFVAFCVLNTLLGGGGSFSAGGPGKGMFSRLYTDVLHNYHWMYNCTSYNHSYDDTGIFYIRASGPPENYVDMVKIIIDQFFQLIVDTIPEEELKRAKTQLKSQIFMNLEMRPVVFEDLARQVLTHEKRIRPEEYGEQIDKITAADIERCVEHLLSSKPSIVGYGDLKTMPSYEKIDSCCATRTTTPLAKKSMFTVLRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEF1</accession>
    <name>A0A914YEF1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17133.t1">
        <property type="protein sequence ID" value="PSU_v2.g17133.t1"/>
        <property type="gene ID" value="PSU_v2.g17133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17133.t1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37383" checksum="254BD22677091A47" modified="2023-02-22" version="1">MLKNLFARNLSAAQIRTMKIIPIPALQDNYQYLIIDNNGKNQAAIVDPVDVNEIKKVAEKVNVQLIAGFVTHHHMDHSAHSGKLRSTFGDTTEVFGHDSKRINGQTMDTVQGGTFSLGDLKVTTYHTPCHTSTHVCYFVVDQKSDERAVFTGDTLFIGGCGRFFEGNAQEMDEALNKTLASLPDDTKVYCGHEYTVQNLKFAKKVDPKNPAVEEKFQWAQKMRESKQYTIPSTIGDEKMFNPFMRVREEALQVATGKTDPIDVMQALXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIDVMQALRDMKNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFJ2</accession>
    <name>A0A914YFJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFJ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16131.t1">
        <property type="protein sequence ID" value="PSU_v2.g16131.t1"/>
        <property type="gene ID" value="PSU_v2.g16131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021640">
        <property type="entry name" value="Mediator_Med28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11594">
        <property type="entry name" value="Med28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16131.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10603" checksum="7FA088BB49014C38" modified="2023-02-22" version="1">MICTDRLYQSFNNLILDFFPEPRLAVPPQGDIKESAEFNVKTFRDACQELTAELTRSAVEWQLVNPQEYYADEIKDLEKAISRQTEIQKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGF8</accession>
    <name>A0A914YGF8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19389.t1">
        <property type="protein sequence ID" value="PSU_v2.g19389.t1"/>
        <property type="gene ID" value="PSU_v2.g19389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19389.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23839" checksum="B818016B4F1F7FF2" modified="2023-02-22" version="1">MRHSSKLSGKSGNKKNLADAISSGEKVSLCAVIGSGGHTGEMSTLLSQLNSDLFIPRHYIVAETDKMGIDKVMEIEKDLYEKQTNHLMKTNEIFTVTKIPRSREVGQSYFSSIFTTLWAILSSIMAVWKLKPDIILCNGPGTCIPICLIAFFFDLIRLKNTRIIFVESVCRVKTLSLSGKILYTLRIADIFLVQWEDLVKLYPRAEYIGILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGU2</accession>
    <name>A0A914YGU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGU2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19527.t1">
        <property type="protein sequence ID" value="PSU_v2.g19527.t1"/>
        <property type="gene ID" value="PSU_v2.g19527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19527.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="12786" checksum="687F9373F54A2BD6" modified="2023-02-22" version="1">MRSTQPAGQTPGFVGTVFMHQSGPDADCLGAVHPLGLGQPAVAACPLFHSDACIGTGRSGGLLAEPGHHRLPPDQWFADCLCGRCGPGADCTADALEFVSAGCPDPSAGPYPQDRPLPGTDPDHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGW8</accession>
    <name>A0A914YGW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein SPT2 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGW8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1656.t1">
        <property type="protein sequence ID" value="PSU_v2.g1656.t1"/>
        <property type="gene ID" value="PSU_v2.g1656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1656.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30534" checksum="5067A5F8FACAA9FF" modified="2023-02-22" version="1">MPVQQNPPPPKPKLPRDPPPSIKEVKKAQMAAASKASSLQKDIKKPRPGPPSKSGTTSSISQKPVSKYPSNNNNSSTKPAMMSKNVDRPGMNDRTKSVVDGKLKNPERFRNSNPPVKRPASMPVDRYNPPPSAKRPTSMSTDRYNPVQKDRFMPSSHDRYNAQPYTRHSIPSKRPRYDDQEDDYDDDEDSMDDFIVDDEAEDVEKELRSVLRGYCRSDETVWQKREREIDLSKMNARFHDIDAEEKRSTRIARLEDMIEEHRGSQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJQ4</accession>
    <name>A0A914YJQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJQ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19755.t1">
        <property type="protein sequence ID" value="PSU_v2.g19755.t1"/>
        <property type="gene ID" value="PSU_v2.g19755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036850839" evidence="2">
        <location>
            <begin position="26"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19755.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="30880" checksum="8140D27250098DBC" modified="2023-02-22" version="1">MATTNFSSLFFLTLLGLSTFGGSFGFPYHGQRFQGGVQRSAPSNDMGAAFGAQQIPPPQTNDMEPLIAVQQPPLEGSTQQQQTSQPEAVQSVQQSSQPETVQPVQQSSQPEQSLPAPEPLQQSPPVESTEPLQPSSSAGSPEPYQQSSSTDIEPLEQTPPAETVESSIIEPIDNETDSTQVIVQTLTEAERSHLISYFLCEMCKELQVSMCMRICNGDSTEGSGSGAEIEASGDEVESSGEGSGEDGGDTIIIIVEESSNSEGSGQESSNGNGAEASGSESSGFGDESEASGDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKG2</accession>
    <name>A0A914YKG2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914YKG2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20011.t1">
        <property type="protein sequence ID" value="PSU_v2.g20011.t1"/>
        <property type="gene ID" value="PSU_v2.g20011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20011.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15939" checksum="5C4480B54E41D894" modified="2023-02-22" version="1">MAIFGHMFHKNAVLRNPNGQWYVSYEEYDKTYYPDMVQGPCYLLSSKAVKAILIEAKNHKHITVDDAFYTGIVAEAAEITVIDANKNFGYRNPLDEGDQKCDENGRPFLFSIADKDGEIKNIPDGYNEQLKKLKALKCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLE7</accession>
    <name>A0A914YLE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLE7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18144.t1">
        <property type="protein sequence ID" value="PSU_v2.g18144.t1"/>
        <property type="gene ID" value="PSU_v2.g18144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18144.t1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45334" checksum="37D6AF4107DDD5F5" modified="2023-02-22" version="1">MNESITKNLFLATRDRAAEVVLRKELQEKERQQKLEVKRKEQEERLKRIGEHKNQLILQRAREKAERDLQKSKAVIDRRLAQLEQEKKKKEEILQKAHSATSRTAQNSQKKVFAFGSSTPRELSYLEKLSKDQKQYDRRLAPPSTPSSNASPSITPPRDTHSTRNSSVTRGPKLMLGNNMTSSLYVPQKAKPAAPRVSPPKRTSPAKVFPPAKANPMTQSLYVSKKSSTPTHSNNKPTPKARNASPAKHLLTNKRSPATSITQLQAQRKPPIPKAPTAGTPARAPPKIQAFEKTESEKPKAIIPRKIVESQDPPEPPNVSIKAPIIVTEEKQDETPKEDEGHISPPSTPAVEQPLNEDHKVEPQEIVEAVEKQFYVAPNEHQIIDEQSVEPQTYRSPNLFKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLG4</accession>
    <name>A0A914YLG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21181.t1">
        <property type="protein sequence ID" value="PSU_v2.g21181.t1"/>
        <property type="gene ID" value="PSU_v2.g21181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21181.t1"/>
        </source>
    </evidence>
    <sequence length="561" mass="64039" checksum="4E0BDD559DB8C7BD" modified="2023-02-22" version="1">MSVKNKTKCTKKGDEVGAIFHKVNGGKLCITYKMLKEKNKNLLKVEPNEMKSFIDNLAKSMIKTDAAILQIFDCQFRGFSSNQEICAAFQSQLTSLKIPYCFITDEQVIAMAALIIAKIEVKLGLIVSIMYLHEQTLNIYEYKFTKKGYKKLQFNSMILDEKDPSFKEVIDRADTNHPQHIILLSSDQANPLYISLNAAMKIFGHKVGTMDGDVATAKDCIVNEISKWLLDKTSTTYYVHPTCARKHKIMTTYDCKELLTVDLNESLPLTKSIILPRTVIIIQQIDKNNGNIVCDTHGMEQKCHRNKITLSVDANNFAKFESVPVMMPQIESLPLILTKSMESKIPVIGFYDNFSVICMHKDDETQYKFVEKWNGKYGKELYISFGNKKPSFGEEALKYCSEIHSLTKFEFGATLMFCFDPRKPLAGESIENPYSSEMEDERMKEFSSVVFDLIKIMSMPADNIKVEDSWGFRITKDDENPVLLEFKNYEKTLKLASPAFLMALLLKEHLRVMKDEIGEKPGEIGFCILDEKYSNAEKERIKQGLEEACKLLKIVCSFVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLN0</accession>
    <name>A0A914YLN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLN0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21238.t1">
        <property type="protein sequence ID" value="PSU_v2.g21238.t1"/>
        <property type="gene ID" value="PSU_v2.g21238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21238.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10010" checksum="01F4E070D75D504D" modified="2023-02-22" version="1">MVDIKFNGEYLTSSRGVQKIVQIILGFVVCSVLCANWYGGTSCFGDGRLGYVSGLNFVIVVMNIILFLLNMMNIGTRRFVSFSFFFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMI9</accession>
    <name>A0A914YMI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2155.t1">
        <property type="protein sequence ID" value="PSU_v2.g2155.t1"/>
        <property type="gene ID" value="PSU_v2.g2155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2155.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="55406" checksum="7A0A92D3B4B8E64D" modified="2023-02-22" version="1">MTKNNEIALMECIPEPEYEYIYQDEDGNIIPVYYQYEEETENNIEYQYTDGLKDGEIFQENYNIEEFGGESFIYESTSQVNEIQQQQISQDPGTHIDDIINVVAHGDIVYEETKKRKGPTIKECEYCGLTLKYPSKIAAHMRTHTGERPYSCKYCRQTFTQRTPWKSHLKRHEGDTPFKCSYCSKAFPNPSTCKAHIKRVHLKKPKAHPGQIINSNISCQKRNEDETQKSQDVEETIATKTLKECLKEQEKQVYICQVCGIHIRHPSKVSSHMLTHRGYKYKPFQCQFCGLLLTTFSSHNVHIKRFHSAEKPYSCQWECGKAFPTQSNRNEHEKIVHHKIKRYQCCINNCNKLFTRRFYLCKHFTKCHSDWELVPDEVKGNRVVAIPFQEEEKLPEQSTSKPSLITVHSDGTKYLVQIMGPLGQPPFHDPAFVENEFINFYSSNNEDLEETSSILEPENGEIIVQNDQDLEEMFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMJ9</accession>
    <name>A0A914YMJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMJ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18550.t1">
        <property type="protein sequence ID" value="PSU_v2.g18550.t1"/>
        <property type="gene ID" value="PSU_v2.g18550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18550.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15718" checksum="9ECF16EB188CD442" modified="2023-02-22" version="1">MLLFKRKDKKLTKQNSRSDSVDRNSGNQSKPILSVPLKTAVTNSKCYDGIPVPALVRNCIDYVEENGLDVEGIYRVSAFISRLDELERQANSGGIITFADPHDAAGLLKRFLRQLPDHILQFSPFVPSKFENVAESIHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP04</accession>
    <name>A0A914YP04_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YP04"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20705.t1">
        <property type="protein sequence ID" value="PSU_v2.g20705.t1"/>
        <property type="gene ID" value="PSU_v2.g20705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20705.t1"/>
        </source>
    </evidence>
    <sequence length="732" mass="86556" checksum="81E525F302EE6B93" modified="2023-02-22" version="1">MVFETLVADLLNRFLGDFVDNLDASQLNIGIWGDVKLNNLEIKNTALDELDLPIKLKYGFLDNLVLKIPWKNLYTEPVLANIDGLYLIVVPNVGVVYNKEKAEKRDQETKQKELLKLEEKRKYQRKPKDPAADTFTEKMIAHLIKNLQVTIKNIHIRFEDKYTNRQHPFVAGFTLEGLDFQTTDKHWKAAILNNTVSLFHKLISMQNLAVYWNSNSKFISDLSEKQEIRKALKEIIATENDKPEDYKYIVIVLQLTTMEAKLAINQKPESDGFTIPKIDLNIEVNELALAISTFQYQSIQLVLEAQERFNIAARYLKYRPNLIEYRGHYRKWWHFAYKCILEENIRRKRRNWSWKRMKDHRKLVKIYQDAWMKKLTEQNLGRDVINIIKNAEHELDVFNLNIARQQAEMKVDRKGLTRIEDQGWTAWAYSWWGGSSNTKEHEHLELEGDIIAKIQQEMTPVEKQKLFDAIDYHGNTPPPDYPEEYIENKIRLHLTSLIVTIEESLEWKFNELSINVEQRQSFRTIHMFFSSLIVETLYEINCQLPTQKFVTELNEFVAILSYSDLLILYNLYNGIPFNDKKIQFEKIFFTAEQLCFTFLDEFHGATIPMLRLMLSTIQIETYSEDKILSYFILSSDYFNQQHFDWEPFLEPWLVQNFRIRVKPDCIRFWLKSDSPVPLDFNVTQTFCQQFKSAQSKWPVHKEDVVQELQAPHHFNIDGEINIPAGFDFEVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP74</accession>
    <name>A0A914YP74_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7774 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP74"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21222.t1">
        <property type="protein sequence ID" value="PSU_v2.g21222.t1"/>
        <property type="gene ID" value="PSU_v2.g21222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056676">
        <property type="entry name" value="DUF7774"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24983">
        <property type="entry name" value="DUF7774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7774" evidence="3">
        <location>
            <begin position="335"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21222.t1"/>
        </source>
    </evidence>
    <sequence length="713" mass="76656" checksum="8CE94BF2B9889F58" modified="2023-02-22" version="1">MSDAVDKAGTKSNKSAGGRSDTDLQHLRAKFHATQFRFTSALAAEHGKASDGAFRIQLKSIDNLKPTKLPPKDIYEPIETFENEEGLKDVEAKEPEYDMFGGSDSSSDESGLMEEWDPAFIAEIQKKCNIRWREAVMEEDPLTDKDELQAIRKRRAEEIKAKENKKKEEIKHVKVAEAISRESGIAPATSSPSLSKESLDHPHAPAFSPGALPSAEPLIPATNIHHLTLSQEALGLTLSKESLLPNAIESESKQNVTTTKKCAEPLFDCLDSDIVLDDSNLSDITNGLKEGMTYDNALVTDDLKKKLLEIDANKEKVEAELIRKALEREDTPVKTDATANKIVEALTDYEVIAKTVAVEDSKMLKEYFDGSRKADDEVIAALDRVIDRILDRAADFYSNKEELALFLRNRGTAKSNLLDAMLSRKGGWLQNMYGSAYSTALAIYSGANKTVEVVGKGLAAAKDVAGQSATMARDYAATTVDVVNRSYTKANELAEQSATVAREVATKGSEMYSKAADVASYSTEQARRVASVTALFAGKVSSVVSTASSLASSSSTTSTSSVTGTSTTGSSTTEYESVPSTAATSTSDVSALPSTSSSSTVESQTGETGSTTNSSLASATGSGADESKSTDEEEKTLIRNPSADSPVPLTFNGFMHCPSPPKPTPAPKTESIFTTIWKTLTEVSMAAYGGNPLESRESSKEEEPPKEDKSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRB0</accession>
    <name>A0A914YRB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">I/LWEQ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1992.t1">
        <property type="protein sequence ID" value="PSU_v2.g1992.t1"/>
        <property type="gene ID" value="PSU_v2.g1992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="I/LWEQ" evidence="5">
        <location>
            <begin position="586"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="246"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="358"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1992.t1"/>
        </source>
    </evidence>
    <sequence length="702" mass="79025" checksum="0B40B533824FD031" modified="2023-02-22" version="1">MLNRLVQLGNFWQHLRTSGYGGANFSYCNALVKRLEFHHRHGSIPGSFELTAPQIGVLSQDVNDAFELTIELLDQLDSLLELKNSVTSTMDSLRWSSLILQGQCLLAPLVLVIIDTSKIYDITVKLLFKLHSQLPADVLAGHRSRFNTAYRGLKKFYDEASGLQYFQYLVSITPLPADPPNFLSANGMENYQSPQAFLHNEGSSEGGDTPPDSQSMADESLIVDLDFAQPVTTPAPPSKDSKDLHIEQLERDNMMLRQQQEKLIQEAKSRIGDYENSLQSLHSDRDYWKERHSELQEESQRYRQTLEQNQQNSQNSQQLQSKLAEKDEQYLKLKGAYTTFRSEHLQALRDIGELTKKTKSFEEAEAKSEEEIRKLKQQILEAEQDRRVFEQKAKTTATSVDEMESSLALSQIEIENLNKKLMEAESIHSKNLAELKDSINTLFASICISILKLLEEAGDDLHNAPSITYPSHLIANALIADIELLNKLTPIIKEKKVSNELCEYLPLFGHRIANTIVNAAAAAYTASIEKYDDVNDVCKQLLQATVTLIKDFQLNNFERIVSTSLPEVDEKLKKLSDTIKKLPTLSGDVDAEQVGAELESEMDRVNKAIADAVQMIEALQKRSRENASGVRMEVNDKILDSCNDLISAIRILVARSRDVQEEIVHQGRGTASPREFYKRNHQWTEGLLSAAKAVGGAATYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRE9</accession>
    <name>A0A914YRE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRE9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2589.t1">
        <property type="protein sequence ID" value="PSU_v2.g2589.t1"/>
        <property type="gene ID" value="PSU_v2.g2589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF20">
        <property type="entry name" value="FOLATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028739">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2589.t1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49222" checksum="CB1A39D09AE7E76A" modified="2023-02-22" version="1">MHWKFTALLVCIYGVVKEFRPGTPFLTPFLESEFKNFTNEIIYSEIYPFWTYSYLLFLIPVFFLTDALRYKPVVILEALSLCATWALMIWGKSVRQMQLMQICFGLASSAEIAYYSYMYAVVDRKHYKKITSYTRAAKMVGKFFAYSLAQIFITTGFGSYLLLIQITFGAVFVVFFISLFLPPIAKPRLQGEIVEIQELKKNNISQISETNHSSSFFKDIKQKLSIFKENETVLIWSIWWALASCGTFQISNYVQTLWARLQNDGQFVGNGMVECVNTLLGAIITFYLQYIKFEWKKYGEFIFFTSSLAISISLLGMSEINNIFILYGLYLFTDCIYHMLIAAASNIIASQLNSASYSFIFGFNTFIALIFQTILTFLVTDKHGFALKIQDQFRIYSGYFLIMALLFCIPFGLKVIKKRNMGTVIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRV0</accession>
    <name>A0A914YRV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRV0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3474.t1">
        <property type="protein sequence ID" value="PSU_v2.g3474.t1"/>
        <property type="gene ID" value="PSU_v2.g3474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000017">
        <property type="entry name" value="Protein CBG05119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037824623" evidence="1">
        <location>
            <begin position="21"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3474.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43312" checksum="E9E26DEF9C07EC18" modified="2023-02-22" version="1">MKAGLTLLLAIGCLLGFANARVFRENEQFGGPRKWGDPITDIGGSISCDPLMMVPSKNIPTNVNSLRPADIKLVMALGDSLTAANGAGAEDPLEIILQYRGLAFLAGGDKSLEQHITIPNILRKFNTNLFGQSKGIGASDVWNVAYLNSAVPGAKADDLPGQALDLVQKLQTHSEVDMNNDWKLLNIFIGGNDVCGYCKDPSKNTPEMFRQNIEKAVQIIKDHVPRVIVSLTTMLHLEMVRQIDRNQYFCKALHVDECKCEQMANFTDSQISEVCTKMQQVEKDIETSGEYEADDFTFVVQPFLNEITTPPMRNGTVFIEFFTPDCFHFAQNGHAITASWIWNNMMEAVGSKTTKGDLGNPATPLKCPDPKCPFVRTPKNSQDCSKYLTDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRX9</accession>
    <name>A0A914YRX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin heavy chain</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2770.t1">
        <property type="protein sequence ID" value="PSU_v2.g2770.t1"/>
        <property type="gene ID" value="PSU_v2.g2770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="11">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="85"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2770.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27671" checksum="7CEA68FC0101B224" modified="2023-02-22" version="1">MVNLEWIQDPGWQYLRLTDDVALKEQAMRKFDNKTHCWVPDPAEGFIIADISIVEGNNYTLTLPNGETRKVNKDETQEINPAKYEKTEDMANLTFLNEASVLHNLRQRYYGMMIYTYSGLFLVFINPYKMLPIYTDSVANMYVNRRRSEVPPHLFAVSDLAYRNMMGEKENQSMLITGESGAGKTENTKKVISYFARIGGAPKEQKSKKSVRFSDQIVLFAVILFYPFKTPQYILFLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSM1</accession>
    <name>A0A914YSM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSM1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3702.t1">
        <property type="protein sequence ID" value="PSU_v2.g3702.t1"/>
        <property type="gene ID" value="PSU_v2.g3702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3702.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17104" checksum="EE78F78F89C12D14" modified="2023-02-22" version="1">MIGAMSSEKRASIQLKNSNQDGKKASLAGRLSEQMTPPKESRALSTCGQLFLCIIGTLMSSVICIWESIFGNDATWRRILVSSFAAFCAVCFTLLAIAIIKRQQKIPHWEPIPIHRHSVSTRRATNAGRHSGDAEACSHDHTVHVEKKMSTVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT22</accession>
    <name>A0A914YT22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3309.t1">
        <property type="protein sequence ID" value="PSU_v2.g3309.t1"/>
        <property type="gene ID" value="PSU_v2.g3309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3309.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8741" checksum="EC8A9761BA62EB69" modified="2023-02-22" version="1">MSTEDKSYVEQAKEGLASAAETAKESLQSAAETVQEYATDLKNKVVGEKPTEQKAADKVKVCFFAYYFFNSVNMRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTH8</accession>
    <name>A0A914YTH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2973.t1">
        <property type="protein sequence ID" value="PSU_v2.g2973.t1"/>
        <property type="gene ID" value="PSU_v2.g2973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2973.t1"/>
        </source>
    </evidence>
    <sequence length="909" mass="101344" checksum="8A46618D6DF73696" modified="2023-02-22" version="1">MPRTRRSLAAAAKPLPVATSSKPVTRRSVAAAVVSPPPVVLELFPRARRACTIAAKVSPLVKKVTPRGRRAATASKPLPVVKASTRRSTAKLLPKIEVIDNEEEEKEEDEDDDEEEDDDYEAEAEEINEEDERMPSDVEFEEKPKAKRTRISIPQETPDKRKKISVAKGEIPGSHSRLKIIGDNKRFKFRTSACTNSKVTPFNVQEYLTSTRNSRDSFFATMSENGCIEELLNSEEVTFNSTVPDSENLTKWLDRSSIKFTFRTGYSPKKKHELTIKDLPPPTSKPDTSIPIFGSVSFEYDLGRPKHDMNSLLVDAMIKSPNLISNTKVYETLDEISKAPESRNQKIQAFFCGGPILSVKPAPLCTSDGYQVVAVTAVGDEITWNHQPGMPSYIQFWKFSGLLTMENPAIWFLLRIENVGTISDMCWCPFFHEKVLLENSDNSKILGYLAVTTDVGKILIFKINKNIDLPSDNPPIVISIPLFVLEHPIVPVGKPQKVDFEDLFQSVIEDNNNTLPSTSEFEASEITESIESIATPKKTATRKSAPKKIVENPTESEFGDEEDIEMENTEKLHEMEGKENEENETKPESTEVDSAPFICVDWSPFSKCKDIVAVSAAGWIFFYDLTKGTEANDALNDLSWDSQPSSAKWISCDTIAVGFTSKLIIFYNVNTKERLFEDNTARSVGTMVATQPVLFPGAFSYDSVRVIPENNLVQYQAGVYQTVNRETQTGLVVPLPNKHIGQVFNLHVCETTGIIGTVGCDGRLLESLNGRVTCRDVENDFACFAYRPTLQLIRHKIDKQHQTINTDFELSLASTEMKEDPEAADTVCCEPIIAHDKVVSSNWLEIRVGDATLIDQEQGSKGWSSVYVEKTTFDRRMESLTRLEFSKLTPGLAITGGEAGIVFIVPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUG1</accession>
    <name>A0A914YUG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUG1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3626.t1">
        <property type="protein sequence ID" value="PSU_v2.g3626.t1"/>
        <property type="gene ID" value="PSU_v2.g3626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="231"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3626.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43816" checksum="02CAD167BC0EE470" modified="2023-02-22" version="1">MSKERSVRFSTKKPIEHESFDYGDDGNTDFEKLMRMPPPALIEDKKFDQLDMCTAASLGWEFVEKIASTSVECSVKKNIAEWSPLMYAAYLGHVQVCEFLCSKGAPLEDKNELGQTALMLAASCGSKDMVVFLVNRGAEVNCQDKSGRSSLHYATQYNQSTITEVLAKAGGDPNLADKNGMTPMLNACKVGNDATVSLLFEYKGDPNRTNYAGENGEALAAEQPNVLKALQSQLTMNDVLRQLGLEKYIPIFEKSDITLNVFLNLKEKDLTELGITLFGPKKKLLNVIQQYKENGIIATEQDVVISQPQLEIPPRSRENSYNNLKNFNNHSENNKISTINTVDLQNQITVNSEVQAFLFKLMESKKIDDQTTMKCQNLIQRISAATDRLNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVJ6</accession>
    <name>A0A914YVJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVJ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4605.t1">
        <property type="protein sequence ID" value="PSU_v2.g4605.t1"/>
        <property type="gene ID" value="PSU_v2.g4605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013314">
        <property type="entry name" value="Globin_lamprey/hagfish"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46783">
        <property type="entry name" value="CYTOGLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46783:SF1">
        <property type="entry name" value="CYTOGLOBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="53"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4605.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22999" checksum="DF7A15AA96CC0370" modified="2023-02-22" version="1">MFRYSGTNFDKEKMASSESLPLDFSVLNIKPSPIEELTAMGRPGSESHKEVSRLNLERRELITESYEQMKKGSVKNCLAVFVRMFAENPHYKNIWPQFRGIPDSSLISSDQLKNHAKVYFGGLNNIIESMNAGDETEFRNMIRRMARSHAKFAVRKSHINAMLPEFIAVLKVCGVPITEEIKDAWYTLFDVIGNLLSPIPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWE4</accession>
    <name>A0A914YWE4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 7">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Pseudopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3980.t1">
        <property type="protein sequence ID" value="PSU_v2.g3980.t1"/>
        <property type="gene ID" value="PSU_v2.g3980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051155">
        <property type="entry name" value="Nematode_MSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22920">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22920:SF21">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="9">
        <location>
            <begin position="160"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3980.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30248" checksum="CD6B6D529CCA7B2B" modified="2023-02-22" version="1">MLQLNIHHLMLKNFPEGEVKSSRSVKTARTQSDRTASAAASLIGINKNQSITPLITPPPTPAPPAATKKQDDSSRQTRQSLYLPAPGEKAPESPPPPRTPTASLYLPAPGEKTPPPNPMLNDSNYRLSSASNTSLASSAAADAAASISDSSVEGDKNPDDFITIPTKKLVFNSPFDYQALTYHVTVKNNSKKWIAYAIKSNAIPRVTAMPPSGILKPGDKQVIGITVQKFVYYDIDASKDRIAFDYLFCPAETKVFTHSLLQGTATRRRKNIKIEYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWL7</accession>
    <name>A0A914YWL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWL7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4498.t1">
        <property type="protein sequence ID" value="PSU_v2.g4498.t1"/>
        <property type="gene ID" value="PSU_v2.g4498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4498.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18826" checksum="BE04930AD4E197F0" modified="2023-02-22" version="1">MVSPGTNSVENTLNTLRYADRVKELGSDEEGHVNKQPLSDAEFMLEEIDDDEYYSKSINTNNTSKHNNHHNHHNNHNHHNHHHQNSNSTTNNNIDLEENLLIKIRNAEERTFEDHHALLTVCDKFEELMQSQNDTDNDVEKYAKHLISTCERGSEAMNNLKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWM2</accession>
    <name>A0A914YWM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4501.t1">
        <property type="protein sequence ID" value="PSU_v2.g4501.t1"/>
        <property type="gene ID" value="PSU_v2.g4501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4501.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22655" checksum="C6208F6832C7C3DE" modified="2023-02-22" version="1">MIIAEDFKLCCKLLLSKNAEDKELDCPNRFCECIDMINIAHQPFIKECTSAKLPQCEITISPWGHDDKLREDVGIILVFKKNVILGGGGIAIFSILSFISLCGFGYLVFICVLYRCCQNKNEEIQVEENYYVDTLAAIDGGYEYSEASIAATTTPHSTITQTTQTITQIPLQQQENQPNSFTTPSASTGDKTKEMTTTISIDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXI0</accession>
    <name>A0A914YXI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXI0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4669.t1">
        <property type="protein sequence ID" value="PSU_v2.g4669.t1"/>
        <property type="gene ID" value="PSU_v2.g4669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4669.t1"/>
        </source>
    </evidence>
    <sequence length="602" mass="69597" checksum="6EDB4DBDB8D62469" modified="2023-02-22" version="1">MPSSQSTYLNIPCPKCQEADCFWHCQKCFMRLRCKDRTIFCSCSQGDILDFEFCCIQKSHDNEFYPYKTNKVYAALERLTLTKSVNILLLGSTGVGKTTLINSIPNYLKFETLEEAEINPLSLLVPTSFQIQDQHYEEIDVKMGNENEFESFEKGKSATRCPKVHTIAYNNVVINFIDTPGLCDTSGINKDKENLNQILNYICSFPELHGIYNEAFRYLCAKKNGISYDQDEYSYCQNAWERSRNETFRLINHVLSNSPHLTNQTAVLNAVRCIIIGLNKPLATITTQIQKNKNLLETHRIEIGNLTGKEKDFRTRIKISQICIKKVPLDRRRVVCNKCAKPKRDDHQNDYKVYPKKCQCPMGHHEHINYKYVENKNFIEDEEIKKELLTVTSKIEAKKRVIKWIGTLIKEYDNEQKLVNRCAAVFSSYLKSNSIILNNKSHEEYLNIELENAKLTGKIADIQNLENALTAYSEEKEILEKQLGQLNTNVSSKELTAADIFAARNKLFNLKWSGSTLRDIFDRELTNPVFHHVNSIQQQITKQKQQCKEDKPSWRKRTQEICATVIAGMTDFTSTNYREPPRIDDYGRALYKGSLNSSPYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXK9</accession>
    <name>A0A914YXK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXK9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4700.t1">
        <property type="protein sequence ID" value="PSU_v2.g4700.t1"/>
        <property type="gene ID" value="PSU_v2.g4700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4700.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7549" checksum="492F45A655FE9AE9" modified="2023-02-22" version="1">MHPNITKITRVSAKNTTTTEETNVAAENKNIVTIQSNTKTKTKTIDGEDTTTAATQKTTAPTQASGENGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYJ6</accession>
    <name>A0A914YYJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IF rod domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYJ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4708.t1">
        <property type="protein sequence ID" value="PSU_v2.g4708.t1"/>
        <property type="gene ID" value="PSU_v2.g4708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000016">
        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000023">
        <property type="entry name" value="Intermediate filament protein ifa-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF12">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="4">
        <location>
            <begin position="27"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4708.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29827" checksum="2202DEDC7A7A37D4" modified="2023-02-22" version="1">MGSSLGSGLSPFGQNAASAIRDSREREKKEMSDLNDKLASYIEKVRFLEAQNRKLAADLELLRGKWGKDTHNIRQMYEAELIEAKKLIDNTNKERDELLKQIKKMEEELNELRRKYDEAVRGHHHDKAVIDDLLVRLSDLEAEINLLRRRITELEENVQRIKKENQRLMSELQRARTELDQETLNRIDYQNQVQTLLEEIDFLRRVHEQEIKELQSLAARDTTPENREFFKNELASAIRDIRRQSTVFVMGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYK9</accession>
    <name>A0A914YYK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYK9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5041.t1">
        <property type="protein sequence ID" value="PSU_v2.g5041.t1"/>
        <property type="gene ID" value="PSU_v2.g5041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5041.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28248" checksum="3A07FE6047FB76DD" modified="2023-02-22" version="1">MDIGVRAAQLISEVTPHIFLTAAQVTLQQHNSTRPTPTNSTPSQVKSEICEPFDTSGSAMSAVERDNTPESSEDEENAPAADAEEFEVEQILDTKMSGRKRLFKVRWKNYGPEYDTWEPEEMLKDGAEESMKEFMIKYEAEKKNSKNSKKRKRPSATPTAAAPKPTRSRSRRSTVEDADDESLPDTVSSSDGEGFTPSSKKKSKPNTNGKTPTPSRNRSGGRTTSPTKPSNERSTPSVAAASVIASNGLFSNVRCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYY5</accession>
    <name>A0A914YYY5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 3'-phospho 5'-phosphosulfate transporter 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PAPS transporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 35 member B3 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYY5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4846.t1">
        <property type="protein sequence ID" value="PSU_v2.g4846.t1"/>
        <property type="gene ID" value="PSU_v2.g4846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF8">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4846.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14747" checksum="BA8D4E4C756D68A0" modified="2023-02-22" version="1">MGLSNASTGYLNYPTQIIFKCCKLIPVLIGGIIIQGKRYGFWDIFAAILMTIGLIMFSLADNQVSPNVNSKGYIMISVALVADAIIGNVQEKSIKTYNAHNNEVVSLYKCLLERNQNFVILFKRRNFESSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZI7</accession>
    <name>A0A914YZI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARD</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZI7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5358.t1">
        <property type="protein sequence ID" value="PSU_v2.g5358.t1"/>
        <property type="gene ID" value="PSU_v2.g5358"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARD"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF1">
        <property type="entry name" value="INACTIVE ACIREDUCTONE DIOXYGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5358.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18293" checksum="6653658FE24453B3" modified="2023-02-22" version="1">MVQIWKLDNFINGDPRLPHHCFPPKKYTPDELTKKTGALYFKLDLDDPLSASKRIAVLKLDRNLKKEDTYTLDAQSTLDFEEKLLELFEEIEGDEQARLVTEGAAYYDVEGFDGSWVRILCEYGDLLIIPKGRPHRMTTTSKNFVKVRRFYKGDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZV1</accession>
    <name>A0A914YZV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp/Glu racemase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZV1"/>
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        <property type="protein sequence ID" value="PSU_v2.g356.t1"/>
        <property type="gene ID" value="PSU_v2.g356"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="BLR3294 PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g356.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12494" checksum="0A3E5455BE42C675" modified="2023-02-22" version="1">MKPLTKRVADYIEAEGIEVQDSISLEVSDNLEVGLLNPENLLEHVKRLNHDGVDAVILSACVQMPSLPAIQRAQDQIGKPVLSAAVCTVYQMLKTLGLETRVPNAGHILSGAKPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0H2</accession>
    <name>A0A914Z0H2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0H2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5379.t1">
        <property type="protein sequence ID" value="PSU_v2.g5379.t1"/>
        <property type="gene ID" value="PSU_v2.g5379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5379.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9343" checksum="30885C171A6FF30B" modified="2023-02-22" version="1">MSGQLPELKGKRVATILTGGNIDSTALGRCIDRGLVYDDRLIRFKVIVSDRPGGISELAKLIADSGASIKDMFMERAWVRQDVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0J3</accession>
    <name>A0A914Z0J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0J3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5400.t1">
        <property type="protein sequence ID" value="PSU_v2.g5400.t1"/>
        <property type="gene ID" value="PSU_v2.g5400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5400.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26615" checksum="280B11E00057D201" modified="2023-02-22" version="1">MDKNLIFYSLNSKNTKLWITGGFVIPSPPPPSSSTSTSSNESSFQGLFCSIISKLYYKCEIARLYLYDISLTLNEFIFLSSSAENVILNNVSIKYCNGEEVELEKLVQFCSKAVKFEYAFLSNATNFSSKTIKNLIKIPHFFMLKKFRLINIPDIFDIKPLLSFLKKTNLYVCLDFCENLSEDYRNQLNDIIVEILDETDNAYLFGPPSLKIPGINFETQLALFRKARYSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0Y0</accession>
    <name>A0A914Z0Y0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0Y0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6016.t1">
        <property type="protein sequence ID" value="PSU_v2.g6016.t1"/>
        <property type="gene ID" value="PSU_v2.g6016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6016.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31838" checksum="3CF296893395C2F1" modified="2023-02-22" version="1">MSNSIWSENLSLSSSSSNETTASNVSSSSSSSYSSFSSGTPSYYLNSGLHVPENVNAETINKAFKDATESVMHTLKLSHAAEAHYNDLNLKLAEKVSDQFTKIEVAKTILESRLSAIQCNNSTLNPQILEGLLNRHKIVKDKLILRQEALSQMLDKANEYRAKSYIGEISDTIEETHNRFLMLKKDINGSTEIEDKLEMIANLLEKFCSLSFYGISAAAASETYEASLEKIEREEIFNDALRQIYHVSECIKKAKEEPCDLLTIDGTSSSKSMNSLNDFLVTVYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3I6</accession>
    <name>A0A914Z3I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3I6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4815.t1">
        <property type="protein sequence ID" value="PSU_v2.g4815.t1"/>
        <property type="gene ID" value="PSU_v2.g4815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037571174" evidence="3">
        <location>
            <begin position="22"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4815.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="23166" checksum="1228DF3BDD5AB64B" modified="2023-02-22" version="1">MKSSKIFVLVFIGVLFALVHGTSTEGVTNDVTTGPVTQAGETTTVQSGNSDSPTGTTDAPATTDGSATGGSSETNAPQTTAAPTTAAPSCPTEDIVFVKDSGTQDFIVNIQPGLNCSYYARSTSFSKSIIIKDPVSFVVSGGGEATLKIFGDNGADSCQSPDPCLPHGTCQVIQGQETCVCAECYIGTKCDIELDPCASYQLVCNTKQPPQQCHKSSPGCTPTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z531</accession>
    <name>A0A914Z531_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z531"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7004.t1">
        <property type="protein sequence ID" value="PSU_v2.g7004.t1"/>
        <property type="gene ID" value="PSU_v2.g7004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037504232" evidence="1">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7004.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10553" checksum="508B1C2153406762" modified="2023-02-22" version="1">MLFFGISLLISTFVTVNSESPVPEIILASNPCPKGWTYVSQINQCYIIPKIFLPWSDAQAYCQNVTGGELVSVYSQFEYDTLLSWLYIFLMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5L7</accession>
    <name>A0A914Z5L7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5L7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7194.t1">
        <property type="protein sequence ID" value="PSU_v2.g7194.t1"/>
        <property type="gene ID" value="PSU_v2.g7194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7194.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20532" checksum="F66310B1FDEFECCD" modified="2023-02-22" version="1">MEIYKDNYDILLASIAAGAHWYLAAFFIETKIVVVYDSLHYPIPQIFTRLKSCIESVLHKQFTLKNENNNITLQQNGYDCGVHAFRNAEEICFHGECKLLVPYYAEAERARAREILRRLKDKEITDLWVPHVQSDFDYIDLNKPTDTVAEEVSVVKDDSDIQSIEKTFAQKNIATTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5Y8</accession>
    <name>A0A914Z5Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5Y8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7754.t1">
        <property type="protein sequence ID" value="PSU_v2.g7754.t1"/>
        <property type="gene ID" value="PSU_v2.g7754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7754.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10023" checksum="2AF907B19EF5C6CC" modified="2023-02-22" version="1">MNYSNAATSFPPPPLSLATSTTGAATTGIPNSNSIGVSRSASAIGLRAAIQYGAAAAAAANHQHQHQQSQNQSQTAANSPVRNRESSNGIPTPTIYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6F9</accession>
    <name>A0A914Z6F9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-bound transcription factor site-2 protease</fullName>
            <ecNumber evidence="3">3.4.24.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endopeptidase S2P</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.</text>
            <dbReference type="EC" id="3.4.24.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.85" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z6F9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7913.t1">
        <property type="protein sequence ID" value="PSU_v2.g7913.t1"/>
        <property type="gene ID" value="PSU_v2.g7913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="11">
        <location>
            <begin position="63"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7913.t1"/>
        </source>
    </evidence>
    <sequence length="484" mass="53784" checksum="E2DD45C830B61BF1" modified="2023-02-22" version="1">MALFSIKSFFDVRISPEGNYKTVGEGDDVEQALSYVPYQHHVQSGITPVIPGVNIPMSHLPLFMFVLVISGIIHELGHAFAAINANVRVTGFGIFIYGIYPGAFTEIDTDELERATSAQKLRIYSAGIWHNLILALLGYFVYISISFLCLPLFHTGAGVLVTDVSTASGLIGPNGLKLGHVITRLNGCEVRDKIEYLRCLALHDNLSPKYGYYLSTTDVFSLTASSNRISSVGGEMACCQEFENITSASHICFQYYNEKLSTNAQTNASLKHSTQMVNFGESLGIKNRAYRANINNVNNAEPTTQTNNGRKLDPLSREELSFACLPAREVTQHFPCSDMTPQQKDGLTCVYPAMYNGTVLLRFDVRNVSNPVIFIGQLTEARFLLNLQDLVPRSQWIPYFIPGQLELSCKYFITFSLALGLLNAVPCHGLDGQFMARTLVDYFFNGQPLYHREKIASIMIIYGTAVFALNLVIGFVKFLIIYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z715</accession>
    <name>A0A914Z715_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z715"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7697.t1">
        <property type="protein sequence ID" value="PSU_v2.g7697.t1"/>
        <property type="gene ID" value="PSU_v2.g7697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF194">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7697.t1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57589" checksum="7FBFC448E69C8603" modified="2023-02-22" version="1">MGAAVFIVFTTCIAVIYYAIYKHLQHRRQFDGIPSPRSYPFVGHMLITKPDSSGFIDQVMGMASLYPNKPRIVAFWTFIMPIVMIYSPESLEPIFTNPKHLNKPFLYDLLKPWLGLGLLTKSAETWRPRRKLLTPTFHYDILKNFVYVFNKQADIMVQQIRKQLETSDEAIEIGNYVTLCALDIICETSMGKCVNAQFESESEYVVAVHRINDIIQRRQKEPWVWNDILFNLIGDGKEHKWALNVLHSFTQKVIKERREEFLKDSMVTSERLAFLDQLLLLEQKGEITVEEIQYEVDTFMFEGHDTTSAGITWACHLLGNHPEVQRKVVEELDAVIGDSHEISYEHLSQLKYCECVIKESLRLYPSVPIFARVLGDDQEVSGHIIPKGTQILVNPYLIHRDPSHWDNAEEFRPERFLPENCVGRNAFAFVPFSAGSRNCIGQRFALMEEKTLLASILRNFQIESVKRRDQQEFTSELILRPVGGVQLKMYPRPSKLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z724</accession>
    <name>A0A914Z724_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z724"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8494.t1">
        <property type="protein sequence ID" value="PSU_v2.g8494.t1"/>
        <property type="gene ID" value="PSU_v2.g8494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8494.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34696" checksum="D86BCEBDF9F858AA" modified="2023-02-22" version="1">MQLIEKLMSKKKTCQFIHPAYRALILKKQRLCRRSKRKIPAAQKLVDRAIHYYSPTPCIIPFLCQNCGMSSCDLEIIRHHNCGKKIGGLSEYSNWKRIVSHGYRSKAKDALAILETIPYPQLAKIKQHKSKNHEEAVDGPIEPTFNPKSLADYAYVALDKIHFSQPPDKFIANGPHRLLKRDMLIDKDDGCAPRRLGYYCFGCQKIYRPYFAFDEHLDEDNSLCAIEPLEVDITSNFPLNGSIVAPTIIPSVKISSFSCTQCHQSDFKNREQFHEHLFECARNPNFDDEYPTPTPTLSEASSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z730</accession>
    <name>A0A914Z730_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phlebovirus glycoprotein G2 fusion domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z730"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7710.t1">
        <property type="protein sequence ID" value="PSU_v2.g7710.t1"/>
        <property type="gene ID" value="PSU_v2.g7710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009878">
        <property type="entry name" value="Phlebovirus_G2_fusion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07245">
        <property type="entry name" value="Phlebovirus_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Phlebovirus glycoprotein G2 fusion" evidence="2">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7710.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29112" checksum="8703347AEED17D1E" modified="2023-02-22" version="1">MATEKSVAMLDEIGIKAAQLFKCESAEEAEKFVNCSLDTTACRCLPADGTVSCSCMQNNVLLKNLNKNALPVKLHDHWIEPTTDRSIVARLNAEPRLQVSVQGLKLKSVIDQNSCKAELHKLSGCSSCVEGAIATFTCTTDFGTAEAHVICDKAVSFPLKCSQRGQFQSINLFFDFAKVDMTCTIKCPSNSAELIIRGLLHHSVEENPWSVRKAADEKENESFIMPILSALQDFWTTTYTLMIVTLIVAAIIAIVILKILKYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z784</accession>
    <name>A0A914Z784_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z784"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8553.t1">
        <property type="protein sequence ID" value="PSU_v2.g8553.t1"/>
        <property type="gene ID" value="PSU_v2.g8553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="286"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8553.t1"/>
        </source>
    </evidence>
    <sequence length="441" mass="51540" checksum="7E78F1C51AE4CD67" modified="2023-02-22" version="1">MGYNMPCKKTIDWNDRIKCPDCKIQFQSHDCFEAHKHRACKHRKVCGKCFKLYNAIKNVHVCGHFYCRECKSSHPKNSKAKGEFHCYIQKAKINKKTDFAPILKIYYDFETVQTLKLIVTKKVRPYPNFDNLNSSNETFETPYLDDVTDAHPHHNEHADHHNIQSNPRIRFEVNNDENGFSRIRDTIELEDEFFNVVNNETSTLTNKNVHQVNTASCLVKCSKCFYETNLTLGCDLCNLNKIITWTSVPNAKPGVFFCDENEDQYPVNLFRDFIIDLSNKQPFTKIILYAHNSSRFDGHLLNRSFVKLGYAPQTIYRGFSIIQSIFKANGSIGCNIFLRDTIKLAPISLAKFAECFGIEDGIAKFEMFPYLLNEPKNYLSKLNMLPAKKYYGYDLMTTKKRAEFDQKYEEENIKMLLENRQFVFVDEIIKYVEMDVITLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7U5</accession>
    <name>A0A914Z7U5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7U5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7939.t1">
        <property type="protein sequence ID" value="PSU_v2.g7939.t1"/>
        <property type="gene ID" value="PSU_v2.g7939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7939.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16946" checksum="ABAA7DBA3FE14829" modified="2023-02-22" version="1">MSPEVNECLETFYGICQELMKDNEETNPWEICLSAFVLPLLSGINDETENEVKNLLEKLKKCDSQRKEMYDATASKIILTNFLHQKVNNESTVLEKLFEKEGKLCLEFNDYSCLRPLAGLIRLHNSSSTDLPLIIQAQLGWFLPVFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8D1</accession>
    <name>A0A914Z8D1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z8D1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6510.t1">
        <property type="protein sequence ID" value="PSU_v2.g6510.t1"/>
        <property type="gene ID" value="PSU_v2.g6510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF111">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="31"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="456"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="658"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6510.t1"/>
        </source>
    </evidence>
    <sequence length="866" mass="98462" checksum="1E7F5A5F1497A667" modified="2023-02-22" version="1">MRIFQIRSSSSFCIERVIEHYNQRCFPNVTQTTLPSFHMVLPPPNVTGNLHLGHALTVVMEDSICRYHRRIGKNVEWYPGFDHAGIATQTVVERQIYKEKGILRSEMLKEEFLQHCNEWKDERINTITSQLKKTGASLNWNNCYYTMDDKFSSAVTRAFCKLHSDGFIFREKRLINWCPTLRSAISDQEVDTITVEGRSKVTPSLKLSSAKKVEVGILHLVRYKLFDGTLNDPEYLEVGTTRPETLFADMALAINPNDEKNSKFIGRHVKHPLTDKILPVIADNVVKINKGTGILKVTPSHDFVDYGIAKRNPNIFGKEYFSCIGEDGKLIDAGKFNGIDRLEAKPMIVEELISREAYGGTLEQGVTHIPVCSRTGDFIEPMLKEQWFMECKEMNQNVLKAIENEKVITFPGGNRQKLIDWLSYDEPWCLSRQLVWGHQIPAYQSADGSWIVSDKPVENLKRDNDVLDTWFSSALIPLVVRGWPHFQIDTVPINLMETGNDIIGFWVARMLILCQHLSGKLPFEKILLHGLVRDSAGRKMSKSLGNVIDPIDIIEGISQGSMIQRLKDSNLSEQEINLAEKDLKSRFPDGMKAVGPDALRFALLRHDLSAEDINVSIVETAQEGYRFCNKVWNLMNYAEIVFSKVELSKLESSQNYVDLWILSKLRNTLKRLQILMDADDDSAAAQPHLAFVALKDFILHDLCDTYLETTKSAINDESDATVSRKEEVAHTLQNILRCTFAALEPFMPFVTSYLGDKIPGKKFDEINLSQIDFSSYPDIEKDMAISLSIVNTVRSFRAALELPKKFQLIGYLQTRNKKKLPLKEAVKELTNLDLNDEKMEGTVPMAVSGQDCTLYIKIEVSLFLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8U5</accession>
    <name>A0A914Z8U5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-aminoethanethiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8U5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6668.t1">
        <property type="protein sequence ID" value="PSU_v2.g6668.t1"/>
        <property type="gene ID" value="PSU_v2.g6668"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6668.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17510" checksum="FA0B53633C181AFC" modified="2023-02-22" version="1">MFESGAEMRPIISILRRISQISDHFPFDGKENFRKEITTLLSQINCKILEIQLPSTMPPLPVQVLCGNVYRNWSKFDSGIFAFPKTGDKLPLHDHPKMEGFIKIIKGKLLVTSFSLLDFDEERKVREENGEEKNQRIRPAKFQESNWDTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z907</accession>
    <name>A0A914Z907_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z907"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8812.t1">
        <property type="protein sequence ID" value="PSU_v2.g8812.t1"/>
        <property type="gene ID" value="PSU_v2.g8812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8812.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10787" checksum="CD2B8A491B472AF8" modified="2023-02-22" version="1">MGEWEGVPSISQVFRLCPKWMIIATFIIIVLGFTGAAAATYSAILELSTTSFQKPCYFFSTQPNNEGHTNCCGENQTISRYNDPNKCSKPDRDYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9A1</accession>
    <name>A0A914Z9A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9A1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9248.t1">
        <property type="protein sequence ID" value="PSU_v2.g9248.t1"/>
        <property type="gene ID" value="PSU_v2.g9248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF8">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9248.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23930" checksum="83D9F9C218F0915C" modified="2023-02-22" version="1">MGACPPLFGKVIVFVAVVESSYKTHYRVAQRSLECYLKSVNYEFKLVDLDHDPKVKKHCKHDQLFFKKHCAASVYLEETDWMLVLDADAGVVNPNHCIEEWIDDRVDIVFYERFFNWEIASGNYLVRNTPFAKDFLRRWADWQFIQPSNWNGADNGVLQIHILQTVMPHAKAEIRACDSVWHRGKDYDTYMAYVTCVKVMLGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9M0</accession>
    <name>A0A914Z9M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9M0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9022.t1">
        <property type="protein sequence ID" value="PSU_v2.g9022.t1"/>
        <property type="gene ID" value="PSU_v2.g9022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298:SF2">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="1">
        <location>
            <begin position="88"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="1">
        <location>
            <begin position="187"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9022.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29875" checksum="AA13305B9A86D1CF" modified="2023-02-22" version="1">MLKYQVRATPAKASLAAVGASPSTSQHRTIISIGANDTIRASTTSLCSSSNSSFASNHSSTNHRYFRTRSNSISSLSSLESSDFADWGHLRIFTGNIKAEIDFKTLKVSTQTSVQQIIEILLSKFRLTCRDPNLYQLWMEVCTRNGSEEVKTLLELDPTSRPLELQRCHPSNQSRFILHQASNGILVRIHDNEICPESNYKSLLISPRTTVIEVIQLVLQIARIHSSTINYRLMLVDENAEAEIPSELVLAAVYLNLSKTQKIVIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAH9</accession>
    <name>A0A914ZAH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAH9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9663.t1">
        <property type="protein sequence ID" value="PSU_v2.g9663.t1"/>
        <property type="gene ID" value="PSU_v2.g9663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9663.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23217" checksum="E035AB12BA6FF459" modified="2023-02-22" version="1">MFGGGTNQYRQDNGRVSEKINKEINNQKQWPSAVDDQRRKGYIDPEVRYGPASPPFSLENYPKPPYDGTSIAERPSGYMEGDDLSRTDVIGGIPYGRTEAIFTTPIPWNSQTTTIISVPSIDIDPKLDFPGNRASRPTEKEIIWNRLTEDARKFPEKGQIRPYFGPEEITRSRYINENPPENNQRDGKVHRFVKIDLPNSSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBA0</accession>
    <name>A0A914ZBA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7528.t1">
        <property type="protein sequence ID" value="PSU_v2.g7528.t1"/>
        <property type="gene ID" value="PSU_v2.g7528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF1">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7528.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27446" checksum="6B6F7AF6A1CB13D5" modified="2023-02-22" version="1">MTKRTCDLCENPLVDTIIYCNESRWLAFPQNWKKIEEIKNSIDLIIVLGTSCKVLAGYEMLFPPDAKIYIVNQGRTEIDELAHVKFNDDCDVVMQALSTTLRLSQPPNYCRTCDPILNPSMNVAINEWPKCICGRRPIRKLAKHLYSTSASILETKLFPSWMVVPLSNKKRSNNSKRKISSPMIVVKEEDERKGKSPFKTEIEDISSSSTTTTTTIMSSTVLEEIELEILPSFNLPVPANNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBZ7</accession>
    <name>A0A914ZBZ7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7774.t1">
        <property type="protein sequence ID" value="PSU_v2.g7774.t1"/>
        <property type="gene ID" value="PSU_v2.g7774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF32">
        <property type="entry name" value="ADP_ATP TRANSLOCASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7774.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13261" checksum="731C37A677DD45FB" modified="2023-02-22" version="1">MKYSDNPEIILLPSPTSRRRMAFVWPNADDAIKFGKDFSVGGAAAVIAKTIVAPIERIKLILQLQASQSTISAENRYKGMIDCLIRVPKEQGFLSFWRGNGTNILRASAQVSSNLIFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFV7</accession>
    <name>A0A914ZFV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A914ZFV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9165.t1">
        <property type="protein sequence ID" value="PSU_v2.g9165.t1"/>
        <property type="gene ID" value="PSU_v2.g9165"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:molecular adaptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SARAH_dom"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="3">
        <location>
            <begin position="337"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9165.t1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44060" checksum="78D745C9D709704A" modified="2023-02-22" version="1">MQNRNGNYRMPGFLEGVPGVYQRRQSPPRLPSTIATPQRRKSGTPDFKKSGVRLSGRTRFGSQSSCASTSMQIPEDSQLITTGNEIPPLQQQRHAAARRPVPRSHPIIPSTASRDLSSHSFSDASKRTELTVFRKSLTSSQSIGNVVQHDLEPKLHLASSAQNVLSVDQQQLRALSYPNGVRNISSSLQSLPGKIPGSSILLNQTPLLNNDDELPLPPYWEVRLTSNGIRYFVDHNNQRTHWIHPLARENLPPGWTKLYDEDLGVVYYNELERRSQFDHPGVATPSSNIAEVHGSRQSIVPNRNKSNEDIEDLNIISEEIPIWLQMYSEAESSSDHLLNFNLFKLQQLEIFDEMLLKLFKQDAINTVIKYEKPRREINSELFRRLIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQT5</accession>
    <name>A0A914XQT5_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XQT5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10366.t1">
        <property type="protein sequence ID" value="PSU_v2.g10366.t1"/>
        <property type="gene ID" value="PSU_v2.g10366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10366.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22683" checksum="5210A4C5275F8BCD" modified="2023-02-22" version="1">MGINENYCSRDDFKTVSLSHNNIVSRGCKNFIVKDGKSDSQRPPKETTTVMQDAKQRQVKKRTKKVTAPAYIPKESSRGNPRQQLIKKPAELSTRGNSNVNVKKCDATVCRVNRYDRRTYFNSNYVFSLGLRYITAYGNDYPEDRGTNKGYLLKSSADVDPNWRNGVPIPCGYKRRWRNESADAHHLNHQNHLQKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSI9</accession>
    <name>A0A914XSI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10236.t1">
        <property type="protein sequence ID" value="PSU_v2.g10236.t1"/>
        <property type="gene ID" value="PSU_v2.g10236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10236.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16497" checksum="7B20D50783BAF901" modified="2023-02-22" version="1">MACMSTTSTVPLTALRGEPGDPGNPGQNGIPIIRGKRAIEGSQDFLHFITQETNFKRAKKLIENERENLLLKLKSSTIIYEEISKEFKKPLFFDSDGGYITSSINLETLEDWKICYFFAENVMLLNNEDSTKGIKMVVSCNGEKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSV7</accession>
    <name>A0A914XSV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XSV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11051.t1">
        <property type="protein sequence ID" value="PSU_v2.g11051.t1"/>
        <property type="gene ID" value="PSU_v2.g11051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF106">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11051.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13227" checksum="BAD320AC4E8C6993" modified="2023-02-22" version="1">MGSLTGFSKSVGFVLASGIGIPQILGTSDLWQWAYLIECIPSIMVLIGMLFFFYDSPVYLIKNGEDKEAYKCLELYHTTNRAQQRLPEIYAELERDKRNHAEGKTTLAAMFNYMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT15</accession>
    <name>A0A914XT15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitoferrin-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XT15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10102.t1">
        <property type="protein sequence ID" value="PSU_v2.g10102.t1"/>
        <property type="gene ID" value="PSU_v2.g10102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF20">
        <property type="entry name" value="MITOFERRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="202"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10102.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34339" checksum="E7E2A818DB431971" modified="2023-02-22" version="1">MADEPDYESLPPTTKIWVNLAAGAMAGVAEHCVMFPVDSVKTRMQSLCPCPETSCKTPVHGIASIIKREGWLRPLRGVNAIAAGSIPAHALYFTVYEKFKQFFTGNTVGHGNTLAYGASGIFATMIHDLVMNPAEVIKQRMQMMYSPYGSSIECARCIYKVEGIGAFYRSYTTQLLMNVPFQAVHFMSYEFWQHILNPEHKYDPSSHLIAGGLAGGLAAAITTPLDCVKTVLNTQQTPCAERNGNSILFKASGSYNGIKDAITSIYHARGLIGFAAGMQARIVYQVPATALSWSVYELFKFILQERPKSVAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT92</accession>
    <name>A0A914XT92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT92"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10185.t1">
        <property type="protein sequence ID" value="PSU_v2.g10185.t1"/>
        <property type="gene ID" value="PSU_v2.g10185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10185.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21792" checksum="5F3B148B48AC1F3B" modified="2023-02-22" version="1">MDYTGCDRVEAIDAIEEFNGDHNRILRYFADLQGGWSNMPGRARGRVRNSEHINRAFDNRGPTSSLGDIGKSESNIAVNYQGVIGTLDNQTHRLQQPVIQITKELGKCDSSDKVASGVLVGKKRSLGFTETTVVSIRPPYKPLNTTTTAASNHPSGQVVPLGVEQDRVTNHQSANPFRQKYRRLYAELDKLSNHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU60</accession>
    <name>A0A914XU60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10071.t1">
        <property type="protein sequence ID" value="PSU_v2.g10071.t1"/>
        <property type="gene ID" value="PSU_v2.g10071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04094">
        <property type="entry name" value="eSelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049394">
        <property type="entry name" value="eEFSec_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049393">
        <property type="entry name" value="eEFSec_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21131">
        <property type="entry name" value="eEFSec_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21208">
        <property type="entry name" value="euk_SelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Selenocysteine-specific elongation factor 3rd" evidence="2">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Selenocysteine-specific elongation factor C-terminal RIFT" evidence="1">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10071.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27059" checksum="DE00BEDFF8611F85" modified="2023-02-22" version="1">MGQRAALLFSNLPETDEIDRTIVFSPGALSKAKHLLITVSKIHQFKYDLKSSSKIHVSIGFETLMADCSFLKECGEEFEQEDGLNSPDITHALLEFQKVIFVKGNDICLAAKLDSQKPTECRFAFYGRILKNLGSAEEIKRFRRKRREGYIDRIETDNTSIICVGLFKKETNLESFNGMSVQIGEKDAGKVENAFGKSGKVRISVPNGISEATKSEVKNGEKVKILLKMKKFIGSNKVVEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU88</accession>
    <name>A0A914XU88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU88"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10100.t1">
        <property type="protein sequence ID" value="PSU_v2.g10100.t1"/>
        <property type="gene ID" value="PSU_v2.g10100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043843">
        <property type="term" value="F:ADP-specific glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF0">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10100.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26519" checksum="88D591E072DC427A" modified="2023-02-22" version="1">MPSLSRGDHYADEFLTRISAQIAAPSTFNMKSLGQTLPPGHSSSIELSRMWSNDFGQRYRTSQPSTASSTLSNQWLKQYNPSQSLSQSSTGSTISTTQRELEGIWNNQGNPSVLLPSFDLEFSIFYSLKGFNYFSGVEAAGATTTKMWSREYLDSFDADPFFEAKLQGNQWANQFLESESIRQNESSSNPQQQQQQTSQEMFENFQTEWDSIANAEFGDNYFGGNTDIGYHFQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUV2</accession>
    <name>A0A914XUV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUV2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11025.t1">
        <property type="protein sequence ID" value="PSU_v2.g11025.t1"/>
        <property type="gene ID" value="PSU_v2.g11025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11025.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="11165" checksum="52883CF4F470AA3B" modified="2023-02-22" version="1">MAEEVTTPISKEDFFIVDDPLAECRHNPAAFTTLEIFLMIFFQLFLFLLYFFGITYLWMLKVRAKAQYFLNALPNRKILRYMKKEQKAPFELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVK0</accession>
    <name>A0A914XVK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVK0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11.t1">
        <property type="protein sequence ID" value="PSU_v2.g11.t1"/>
        <property type="gene ID" value="PSU_v2.g11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11.t1"/>
        </source>
    </evidence>
    <sequence length="1053" mass="118472" checksum="07E9F8F43863EFA1" modified="2023-02-22" version="1">MSSVRNADLIEKMTSADKDFRFMAINDIMESLKNKSITLDDTTENQLITNLLKLLDDPNAEVQNLDVKCLSLLVNYLAQPRLYFTLEALGKKIFEAEEENSRDIAAIALRSSIIEFNSLKNVSFNSVVDRLMPQLVNVLAKSSDNSVNEQILDIITHMFRRTGNKLEFNYDGLNDALFKHAESERYGIRRRAQQALAMYAEVVDNDQFKIIVDRVYKCCKKYMSNSALLKTYVATTTAICKNSGHRFQQSLPAFAELFIQICNRSQEDELREVTIGSFEMFFNRSPEAVTPYVEEISKIVIALLSHDPNYSYDDSDNEEDKMDIDETSADGSDDDEDSDYSDDEDVSWKVRRASAKCVEAIITHRHDLQKNYDTFGKLLIKRMKEREDNVKQDIMNAYLALIRQTRLLIPDSIIPWSLRVDSSCMYEKISMETFNEFINEDDNRKKVFDALNEQIPSLIRRISSAQKTKNTKVLEQTFILLTALVTTYPASIGTNLPQLSRGIKHSLNDRDGNMKLFTLRFLATFFATHDYTEYQSGVENIVNDVFKLAGDFFSKVSSESIEAINSLICSMANSSASMNPKLLEQIYNLLISKFQVTDMDQEVKDKTTYGLGFFVSSFGDSLGSQLDNCLSLLADRLNNEISRQSALKALTIIARSDKDFSMASVIPSVTSHFGEFLRKANRTLRINTLSLAIAIAERTKPGNFDGVDLASTFVEIPILLCDTDLQIAQLALHLAALLVAQHPQQIGPVNPVLEAVIILTKSALVQGKTQKALLEFLDVYTRSDVGSKPEFREFVGQFMEYVTSWKCYSRPAFLTVAKSIATVARGNKVSTVLPLTKELEKIVLKAQTLEIKTLSILTIGELGRLCPAVYAEKTSIKPEEIAVSCFKPTCEEDLKMSASQALGSLAVGNIQRFLPFILTQIKEESSRRYLLVYALRELITSDSVDAAEQQLFLSNIDTIWQGIITQANATESTRIVVAECLGKLCLMNPEKYLPELVNCFKSSDNLVRSSALVAIRYMISDKPIPADALLMKVLPIFFEGVKDENIDTPIFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW83</accession>
    <name>A0A914XW83_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XW83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11219.t1">
        <property type="protein sequence ID" value="PSU_v2.g11219.t1"/>
        <property type="gene ID" value="PSU_v2.g11219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="53"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="252"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11219.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40326" checksum="AB73F243F00700F4" modified="2023-02-22" version="1">MPSVGRECISVHIGQAGAQIGNACWELYCKEHGIDNDGMLSTDADIPPPQQSLNTFFTETDSGKFTPRAIYIDLEPTVLDEIRTGSFRNLFHPEQLISGKEDAANNYARGHYTVGKEHIDRVLERIRKQAESCIGLQGFLVFHSFGGGTGSGFTSLLMERLSVEYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLDIERPSYVNLNRLIAQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISADKAYHEPLSVSDITNMCFEPYNQMVKCDPRNGKYMAVCLLYRGDIVPKDVNAAIASVKTKRSIQFVDWCPTGFKLKEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWA2</accession>
    <name>A0A914XWA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1151.t1">
        <property type="protein sequence ID" value="PSU_v2.g1151.t1"/>
        <property type="gene ID" value="PSU_v2.g1151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1151.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8251" checksum="96081879ED34E150" modified="2023-02-22" version="1">MIDPAKYPDVQEDDEGYYKVFKISEDLSLKLLYWYNVKAHEGDNYVPDYDSDYRDYGYGHRFGYDSDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWF6</accession>
    <name>A0A914XWF6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g12271.t1">
        <property type="protein sequence ID" value="PSU_v2.g12271.t1"/>
        <property type="gene ID" value="PSU_v2.g12271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="584"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12271.t1"/>
        </source>
    </evidence>
    <sequence length="802" mass="88403" checksum="86F50E083B61DC0C" modified="2023-02-22" version="1">MPKKTTDGLKRLPLVVIPKRRKHKNYVSRRRNTQILNSLRRCTSDPNVYKSYNNWKTLCLDLPEPKPLSVPSKAPPPAIVSKNAVGPKAAAVTQRLTNVPASPQSAKRGTVVIPRPSDIKRRESGKAVITAATTTVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVVSPPAAITTKVVPPSPNAAGATSGISRRLNLRKIQAVPSVDAACAPSTSSSNLISSPPESLPASAVPSPQPPPEPLKPQHSAITGRRTSSRRRKSKIDDFATIKRDLMESAAKFELAKKKLSVNDKDKEESTTSDESRAKKTLNAISAAFSDAKVEPTIPTSTLLTGDATSNVAAKPPTTPSSGRKIITKPATPKTKLRNAGPTQPKRTPPVASPQENIAEKDPSSDEEEILRPPEITGISANIKDVIAQAEAALEDEERVKPPILQLSKQPILPPPGQNPQRFQRSMNPQTASLLATLQLPPSVSAKVDKIIATGGKKLQPSTSGDRNDRHHKGTYSTSKNANAIAPSTSGHRNHHSSAHDSTRTSQVQARPRDDTDGHLIYSHGDLVYNRYEIVKTLGEGTFGKVVEVKDRDREHSTSNSRSMALKIIKNVNKYREAARLEINVLQKLKERDPTGQHLVIHMINYFDYYGHTCLLFELLGLSVFDFMKFNNYKPYPMDQARYIAYQLCYAVKFMHDNALTHTDLKPENILFVNSDYDQTEIGERKKTKYKKVKNAAVRLIDLGSATFDHEHHSAIVSTRHYRAPEVILELGWAQPCDTWYVQATVKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXE6</accession>
    <name>A0A914XXE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11882.t1">
        <property type="protein sequence ID" value="PSU_v2.g11882.t1"/>
        <property type="gene ID" value="PSU_v2.g11882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11882.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14863" checksum="DD879FF98C4ABC8B" modified="2023-02-22" version="1">MGFILIFDITNEQSFLNIRDWLSQLKIHAYCEAPDIILCGNKADLENRRQVSTARAKQLADQLGLPYFETSACTSTNVEKSVDCLLDMVMQRIQVSVDGELPAEYLGGGGMAGRITVDDDSAINSGQGMSSYCANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYC5</accession>
    <name>A0A914XYC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XYC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11535.t1">
        <property type="protein sequence ID" value="PSU_v2.g11535.t1"/>
        <property type="gene ID" value="PSU_v2.g11535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11535.t1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45727" checksum="FEC40D27C598CC20" modified="2023-02-22" version="1">MVLFQSPFDAVPVEDKPFGEEKILSKIWKHSIKYPRKKAILCAENEDQYLTYSELYLYSLSVASFLEENGICHGNVAATVMLNDLFYAPIFIGCALRGVTLTSGSMSNTHYELERQFTDASPKIIFCSKDALDRILTATKNLTIKMIIIIDGDKNATYSNSNIFNFSKVFNAVPLPHLPPANINIETDALILPYSSGTTGTPKGVIITHKGFGTHANIYNSVLEKYLQNVCTQKPYISDQEHELLLLPINHMFGCCTLFNCLMMAKTVVLMKQFEPEPFFEAIQKFKIRMLMIHPPVLIMLSKHSSVDKYDLSCIEIIFSSAAAAGKDIIEEVKRKHPNLRQVTQCYGTTECLVATFPDSGNLPNGSVGKVAPLGKLKVVDVETGLELRQGTEATKESIDAEGWRFWVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYU2</accession>
    <name>A0A914XYU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homoserine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYU2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1170.t1">
        <property type="protein sequence ID" value="PSU_v2.g1170.t1"/>
        <property type="gene ID" value="PSU_v2.g1170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048423">
        <property type="entry name" value="DRL_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37850:SF2">
        <property type="entry name" value="SAF DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37850">
        <property type="entry name" value="STRU PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21135">
        <property type="entry name" value="DRL_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase DRL-like catalytic" evidence="1">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1170.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19081" checksum="1EDDD01381D1801E" modified="2023-02-22" version="1">MEHGKHLVMMNVEADVTIGAYLKSEADRLGVTYSLGAGDEPSSCMELIEFVSAMGHPIVAAGKGKNNPLNIDAVPDAYMEEAIRRNMNVRMLVEFVDGSKTMVEMAAIANATGLVPDKAGMHGPAATLDQLSSTLIPEKDGGVLSKVGVVDYTIGKGVAPAYGRPENGQRPLLSPSIARIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ73</accession>
    <name>A0A914XZ73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1097.t1">
        <property type="protein sequence ID" value="PSU_v2.g1097.t1"/>
        <property type="gene ID" value="PSU_v2.g1097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1097.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="6794" checksum="001DBECC953315EB" modified="2023-02-22" version="1">MASVVITSVVCGCVVVGDSVVGAIVDGSGVEVSFIVEVNIAVVDVKASVLVDVETVLVLVVVVISHCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZV1</accession>
    <name>A0A914XZV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13490.t1">
        <property type="protein sequence ID" value="PSU_v2.g13490.t1"/>
        <property type="gene ID" value="PSU_v2.g13490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13490.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9655" checksum="838FBEA2888D7063" modified="2023-02-22" version="1">MARERGVAKKVKDPNAPKRALTAYFIWLAENREAIKKPGMSATQVAKAAGAAWRELTDKSKWEKKAEEDKKRYERENAEYKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1W4</accession>
    <name>A0A914Y1W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1W4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11802.t1">
        <property type="protein sequence ID" value="PSU_v2.g11802.t1"/>
        <property type="gene ID" value="PSU_v2.g11802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037506787" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11802.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16115" checksum="FEBB1852E4784A7B" modified="2023-02-22" version="1">MKLLSLLMFLGIWVAVSTAVNYACMGRDGEDNFCNGKYECKNQKCVLKERREKRTAIGTCTNDAECPFKHSCVFGYCSSHGTKNTFEHLKFAKSNRVHKKLAATKKIEKRSPLNWPHCVDDFECKTHERCFGGVCRADGSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y212</accession>
    <name>A0A914Y212_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y212"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11846.t1">
        <property type="protein sequence ID" value="PSU_v2.g11846.t1"/>
        <property type="gene ID" value="PSU_v2.g11846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="139"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11846.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31067" checksum="72B149D1ACEC78D6" modified="2023-02-22" version="1">MNFMAAEGICEGFGGHLTSIHSIFENVFLYEEASTFFTDSVSIDFWNGANTLYKPGSWTWMDGMPFDFTDWDKGQPQNTTDKNCGAVKLQGGQWISDNCDKLKPFVCLKKVFTSSTTSAALTTTTKPKPKSCDLSWTAHDGFCYKVYDNGTWLEAEERCKVDDAHLASIHDIDENLFVANLSYYPEADGCKWPTNAWVGLFTEDNQAHWNWTDKTHFNYANWMPGKPNLPQYKLNCCIMFLTPCTTTYVVETGQFDNLPCDTILPKFICKKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2K5</accession>
    <name>A0A914Y2K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2K5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1202.t1">
        <property type="protein sequence ID" value="PSU_v2.g1202.t1"/>
        <property type="gene ID" value="PSU_v2.g1202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1202.t1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43185" checksum="114088263A5E0A1E" modified="2023-02-22" version="1">MLPKTSTTPSILPDRYYTSFKANPTAFCCFETEDPEDNTIKSFAIVGTLNGTIEIVALEKGAIPEVKFEHKSESQINAIILIATKPKIYFVAQFRGMELIWFNLDFENGMIKNLIKLKSYSLTHFGFCQSIWDKNEKRMLVPGKDDDYEMLSILYENSGEKAISLGANFLFSSFKKRHPNTEFTVDDCFKGTISSFQQIHETIGYEECDRLLIGFEDATLIIYDIRTKEVINLFKAPSKYSQLIAFAVSKDSEFQRWRIAVTVCSRIFEVNYENQEFELTKRIKKTGFANVNCSHICFNTIGDILICGYSSGRIEFYNVPEYNIFKVMNFHESSILSMNVLTISKNDEILFIGDEEGKMSQMNMKKLKCSQNVQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2P1</accession>
    <name>A0A914Y2P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">L-serine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2P1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14446.t1">
        <property type="protein sequence ID" value="PSU_v2.g14446.t1"/>
        <property type="gene ID" value="PSU_v2.g14446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000001">
        <property type="entry name" value="L-serine ammonia-lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine dehydratase beta chain" evidence="10">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Serine dehydratase-like alpha subunit" evidence="9">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14446.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27509" checksum="D2BAC6A963D3E3D5" modified="2023-02-22" version="1">MAVSTFDVFKIGIGPSSSHTVGPMKAAERFIHRWLLDPGRLHEVARIRADVYGSLALTGRGHGTDKAILLGLEGQRPNLIDPDIIPATLERIRSSKRIQLMGQHEIAFDEKRDLGMNKRQKLPYHTNGMRFTAYNADDEVIATRDYYSVGGGFVVNQDDAADDRIVPDETPLPYPFKSGDELLAQTARSGLSIAQLMFENEKCWRSEDEIRANLREIWSAMQSCVARGIREEGVLPGGLKRRCATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y337</accession>
    <name>A0A914Y337_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y337"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13192.t1">
        <property type="protein sequence ID" value="PSU_v2.g13192.t1"/>
        <property type="gene ID" value="PSU_v2.g13192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13192.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23800" checksum="7E9BCBF775260AA2" modified="2023-02-22" version="1">MNTLSSPASLDFLVKDFESRKLAFEQWKIQHSAAQGSEAYNTYVTQFRDYEIQMNKIIGEHKSVPPVQIGENLDAQLHSLLSKCKKEDFILAFLHASANDDSLLKTVKAALDSKSAPKNVPTLINSYGVRPNMPSSSSSPAISISSPLLQHAHGSPSITPSTSTINLRPKIQMTNYGLIPEGWVVDQPIIRPEKLPPPPKTYAEASKLPFFDIGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y360</accession>
    <name>A0A914Y360_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 19 catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y360"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12207.t1">
        <property type="protein sequence ID" value="PSU_v2.g12207.t1"/>
        <property type="gene ID" value="PSU_v2.g12207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47836:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 19 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47836">
        <property type="entry name" value="PROTEIN CBG09520-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 19 catalytic" evidence="2">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12207.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13639" checksum="862C91043B005E6D" modified="2023-02-22" version="1">MGVAVNCPRADRFGRQPPKDCQAATDPNKLPKTSLQKWFTRAEFDDLFPKANHGWGPHKCLPYSYDSFIIASRYFPEFGTASSISKSKFTRNELKRRDIAAFFAHIVQETGETNYDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y425</accession>
    <name>A0A914Y425_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y425"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1419.t1">
        <property type="protein sequence ID" value="PSU_v2.g1419.t1"/>
        <property type="gene ID" value="PSU_v2.g1419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1419.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38365" checksum="403C0A687304B8CA" modified="2023-02-22" version="1">MEGFTAKTFKYMTKLEILDLSKSRGIKKEIFSPFLSNLKTLHLQLCNITTLDDDFFGNLIHLQHLSLGHNPITTVPKAISFIQSLQSLDLCYTDISTLDKHSFIFSDKMESLHLCALKNLTIINDCTFCNFPNLKEIGIDFNENLSTIHENAFGSITAGKPYPKLTKFGFFLTNFSTLSERLIDWRKVDEIYLATKGFNCDCSMAWLINDLQRSDSIFSKKLRFTTFKGTKSVCINPPELKGKKLKEASGKICDGKLSTIYHPSNLSPTISSFNFHWIFLGAIIFGAAILCYIYHNQIIKFIYYQNVSQQENDEFKLHQYFNLDEEEDSASISMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y434</accession>
    <name>A0A914Y434_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General transcription factor IIH subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">General transcription factor IIH polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g1420.t1">
        <property type="protein sequence ID" value="PSU_v2.g1420.t1"/>
        <property type="gene ID" value="PSU_v2.g1420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1420.t1"/>
        </source>
    </evidence>
    <sequence length="790" mass="91383" checksum="FA3612FA26BD26AB" modified="2023-02-22" version="1">MGFEYAQQLQRGLCFIKRMRRESKNELMESKTVIVNFSPDLSEQTTELMTLFFTYQTFHEKIDILDISGDVNPTLQQGCDITGGRYVSLKSFPASLLGCIARNFFISSNSLNLFPTVIEREVDYRFPCRCHNTLVDLGYICASCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRRDLNIQSEKRAAIFPTKKAKKEEKGNGNGNDQSEMPPTPSSKSCTETITKLDQALLFKILDALEGTKTIVWDRFLMTEFNSTVSYQLLKEHNVVSHVCPVINPIVKKTDHILYIIPPYLHSTKELIESHLKKISETDRKKHRIYYVPEVSYVHREELVSAIPWIDKHIFNLPMRWFPTDHSQFISMNLPSLPPVMLIYEDWNELYKCAKGKWSTTVAQILEQLRKTPCEEHVIEAPNVDEIIIIDRWLDLATPLMMQQTFSGVADEIYGIDIQSKIKFETQNFYKGSKIPKSLQEKLQFDFYLNDEIYPELCDNHMMDVSGKIQYFVRECKEEELKYKSVESVAQISECVNSLPRVIKKREATTSYLQMTTLFMNDMSQAERIDYRKCEEDILENKFEDKLIPYIEMCILNAEPLLKILRLISLQSQICNGLKLVTLQAYRKSIVQGYGIEILSWFLRLEMAGLIRCSDKSEKMSTYLPVDFINLKKRFKLFSTEPPQMGDIARYYNGYVPLLIRILEEGEQADFTNWDFIEPAKNVPIKKKLQKDRLLFVVGGVTRAEMGIIKERFPDMKYCCTTATITGNQLIEGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y458</accession>
    <name>A0A914Y458_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y458"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14223.t1">
        <property type="protein sequence ID" value="PSU_v2.g14223.t1"/>
        <property type="gene ID" value="PSU_v2.g14223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="10">
        <location>
            <begin position="187"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="395"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14223.t1"/>
        </source>
    </evidence>
    <sequence length="582" mass="69438" checksum="29DD518BBC626EE7" modified="2023-02-22" version="1">MATEVESMEVDNTATRYSEYFTDEDLPYEENINRNPNDLRPWQRYIDDKLKRKAPPKAIKFLYERALKIFNRSYKLWYAYLKYRRRLIYEKPPTHMAWGHLCDAYERCLVFLNKMPRIWLDYCDIMVRRGLVTESRRIFDRALRALPVTQHNRIWPQYTKFVTSHNVPETTIRVYRRYLKLKPAVREDFVDYLIGIDQLDEAANQLAILVNEDSKASAKGKTTHQLWMELCNLISKNPNKIHTLKADPIIRQGIHRYTDQVGILWLALAEYYTRIPNFERARDIYEEALVSVSTVRDFSQIFDAYSKFAERLVSIKMTALEKAKASETEDKELELELYMTRFEHLIERRPLLLNSVLLRQNPNNVHEWLNRVSLYEGFPTKQIETYEDAVTQIQPKLQTGKLCDLWISFGKFYEKRNELDNARKIFERAIAVNFVKVDDLALVWSEYAEFILRHSGYEETVKLLKRAVASSTRRANFFDENEAVQHRVYKSLRLWSFYADVEESFGTVDSCKAVYEKILDLRIATPQIVVNYAMFLEERNYFEDAFKAYEKGIGIFRWPQVFDIWNVYLTKFIERYVRWKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y510</accession>
    <name>A0A914Y510_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y510"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15288.t1">
        <property type="protein sequence ID" value="PSU_v2.g15288.t1"/>
        <property type="gene ID" value="PSU_v2.g15288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15288.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24013" checksum="8666C3E6048DDC0C" modified="2023-02-22" version="1">MYPSPLTTSQEVTTETQTSPITSSTPEYENPELLGTSFIIKTLPPNLILPSAASASNGITLLPPQIVIKNAIENRPTDYQQQPDEENFSQQQPSGYPNPPPTIDPINFVTKFVTLSPYENLPTISPTINSQPSGMNERQQTLVPLIEENENFEKKPSILRPQPIVPLPKSESVDEDVDEDNDNGRVGGLRVLETAAATSMIPPTFMPENFEIPTRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y586</accession>
    <name>A0A914Y586_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y586"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13934.t1">
        <property type="protein sequence ID" value="PSU_v2.g13934.t1"/>
        <property type="gene ID" value="PSU_v2.g13934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13934.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="25297" checksum="7C69ADC1392F4D06" modified="2023-02-22" version="1">MFYYSLEGYTQLATVFPELLNAQICDVSVIASDNQTYVPGTVDKDQAKYYQIPASISDGLTLKLDIHEGAATVYASFTARLPSASDYDFVANATTENLGQIYISPTILQQASNNSAFIFISDMVALGNADITVYTSVIGISNDTTNFTLHYEPHNTEVTSPTPPSLSTTPPTSPTPPTSPTPPTSPTPPTSPTPPTSPTSPTSPTPPTSPTTHSNNAPISLMPSLLTIFISCILFSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6J0</accession>
    <name>A0A914Y6J0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15065.t1">
        <property type="protein sequence ID" value="PSU_v2.g15065.t1"/>
        <property type="gene ID" value="PSU_v2.g15065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15065.t1"/>
        </source>
    </evidence>
    <sequence length="681" mass="77978" checksum="98EA990C78C2F5A7" modified="2023-02-22" version="1">MESSPEKSQLNLNSSDFEAESYVQNLLQKKGLDELVAIEEDMVQNVRRLDSEMHQLVYENYSKFLTATNTVRNMQTEFQKMSDDMGNLTNKMDKIADLSGSLCNVFDRHRQNVRKLTDASKTVKGLQYIVKLPQRLQNLIDQKDFTKAVSSYIAVKPKLDLYKDVPSMTGICNDCHELIQEVEERLRERLTSRLISSDDLIDAVKMLKELGIPESELETKMVETWKEQIEAELTALKKNEFEDILEFAENGCCNFLTTLSISANIYPQLFSSDNNQRFISMIDEFMEEFEKIVNQRFCAEISGRECALYVRALDRVYRKLAACDRLIFWKDYNILNNDIVVKAAAHQIAIGRKNIVSLFTSTFSEVIEETRNTQLSAAEISQLIHKLEQNFLVSVKTTLANLLLFTASDITFSSIDTASQFLDSSSYAFLILAQFINIMQKKHITYLIDLCQEQFRLTERLMELTLNVTICEKLDEIGKLLLKAYADLKGSEMSALCSESVNNMDWLKAEEPKIVRDEIKKIIEFVKEVSEQTAVLLTDLPRKQQRSPDLGRNITPRHVASTSTFETGSLSSALEKMWTEKVEYNTVIDFKHEVVLLAIVKIGLKSLVEFSRLLLFSCNGLQQMQVDCLFLKQKLWQFVHDEHVLNSLIDEVVASVVIQCTEPRLLEPSVANLICEKSDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y880</accession>
    <name>A0A914Y880_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y880"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16405.t1">
        <property type="protein sequence ID" value="PSU_v2.g16405.t1"/>
        <property type="gene ID" value="PSU_v2.g16405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16405.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="13255" checksum="C47EE154CE18200A" modified="2023-02-22" version="1">MYYCYRMDGAQPPPPPPSAPGGPSGKPSKESAGGGGTGGPSKESKVFSDNVTGNTAMSAVTDSNFGQADGQSAYSLQPETDGKKKKKNDGGSNDSGGQKRSGGACICMITTAILGILSFSSAVGAGIALTMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8L9</accession>
    <name>A0A914Y8L9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8L9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13930.t1">
        <property type="protein sequence ID" value="PSU_v2.g13930.t1"/>
        <property type="gene ID" value="PSU_v2.g13930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13930.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10115" checksum="120DB6A5DEB61970" modified="2023-02-22" version="1">MTVEERKKVRKVLNAKGRADILVCPDDLIKGADGAVTPDQCEIMTEEERKEAQKAADKSGLGITVCPDNGVEKIGYGIGLIVVTLGYFFFINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8Z1</accession>
    <name>A0A914Y8Z1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8Z1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15222.t1">
        <property type="protein sequence ID" value="PSU_v2.g15222.t1"/>
        <property type="gene ID" value="PSU_v2.g15222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15222.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16329" checksum="26875819EA58D554" modified="2023-02-22" version="1">MSLSRLALTPLRLRGPLLAKPLAAASSMVSGYRFAGSNTAPGLSGKPMGEHALHFKIERYFAAAMLPLFPAAYFVHGPVMDALLIAAIALHTHWGIVAVINDYARPIVIGETAARMAIPAAYVLSILLLVGLLHFNINDVGLTRAFEMFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9C5</accession>
    <name>A0A914Y9C5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Site-specific DNA endonuclease</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9C5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16040.t1">
        <property type="protein sequence ID" value="PSU_v2.g16040.t1"/>
        <property type="gene ID" value="PSU_v2.g16040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16040.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="20468" checksum="7240FD2036E28383" modified="2023-02-22" version="1">MLMWQKIEKRKKKNQNCCVKRDITCENYKFYTGGWKHDKHAKIIVFENDNRNLIREYRRDSGSHYYCYGCKRATNIRNRGILKNQIFTVPFNHVCEPVNFDLFEKEQKEYEAKGPSHHHYPPPKTSEKQIRKARLRAYRERCRTRAMSCLPVWLTTTSEPPNKIARIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA68</accession>
    <name>A0A914YA68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chemotaxis methyl-accepting receptor Tar-related ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g171.t1">
        <property type="protein sequence ID" value="PSU_v2.g171.t1"/>
        <property type="gene ID" value="PSU_v2.g171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.30">
        <property type="entry name" value="Aspartate receptor, ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035440">
        <property type="entry name" value="4HB_MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003122">
        <property type="entry name" value="Tar_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02203">
        <property type="entry name" value="TarH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47170">
        <property type="entry name" value="Aspartate receptor, ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Chemotaxis methyl-accepting receptor Tar-related ligand-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g171.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8831" checksum="C5CA9FC8476BD2FB" modified="2023-02-22" version="1">MIQAGAASRIAEMEAMKRNIAQAESEIKQSQQGYRAYQNRPVKTPADEALDTELNQRFQAYITGMQPMLKYAKKWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAK0</accession>
    <name>A0A914YAK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAK0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16307.t1">
        <property type="protein sequence ID" value="PSU_v2.g16307.t1"/>
        <property type="gene ID" value="PSU_v2.g16307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16307.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11138" checksum="23DC508D72EC9D0E" modified="2023-02-22" version="1">MKKKPLRSESGSGAWCPFHQINESSHEWLQIDFLKDTVISAIETQGRYDKGRGMEYSIGYMLEYWRTSLGRWARYKDNQGNEVCKFIIIIIIIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAN9</accession>
    <name>A0A914YAN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAN9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16349.t1">
        <property type="protein sequence ID" value="PSU_v2.g16349.t1"/>
        <property type="gene ID" value="PSU_v2.g16349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16349.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31816" checksum="A89A13E229EF1EC3" modified="2023-02-22" version="1">MLPWKKAKNERVGYEQKERLFMGDYAEQLGDLKPYIDIMTKYLENCRARSVAVVDFPFFGNILEQMAHDWKITGKEPLDWMPDPCGYRNISRVDAAKKAKEKMTSSKKNHKQSQVPPPSTTAAAPSESPPPPPTPQEDEFNFLPVIPLEPVMIKEKETVKEKIEAKSDTAAAKLEATTTTKKLVNDVQTPSDGSYKNVKKDENDKVAGGVTTDKKNINAIRKVSSSNRRGSRATVGAPTTAAKKTLDESDSKKKEKDQNKEEESDHNKSPKKDNDSKDESIESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAT9</accession>
    <name>A0A914YAT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BPL/LPL catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAT9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16544.t1">
        <property type="protein sequence ID" value="PSU_v2.g16544.t1"/>
        <property type="gene ID" value="PSU_v2.g16544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="157"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16544.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41754" checksum="DE27BA06FC0BF3EA" modified="2023-02-22" version="1">MKLLNKNKEVNETFHAKDLIGAMSYSVVIHKKQDQPLLLYMENSANNASALFSDATADELIATGGISLIKDAMKRLKIQVVENQAIPSLTQGYFICEPDKLAGDMNGLVYEKEIGNMPKLFFSNIPTNLPFPTSSFLSIEVCKRKEGLPRSCEFDVEKYYKCLNTKTLGKAMIYFSVCETTMNISKSLFNALPTFDGILVIAGIQTKGFGRSGNQWLSPKGCAMFTFNFNIPLFSNLGQSATFIQHILAVSIVDAVITILQIEDFSLKIKWPNDIYWARMFKMGGILVNSSISGETLHCVIGAGINVCNNKPTVSLNDMIPEDYDKILTVEEVIAETMNKFEQVRSKQNGKVFSVHDNGNTFDMMKGLIRPKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBT5</accession>
    <name>A0A914YBT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBT5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17667.t1">
        <property type="protein sequence ID" value="PSU_v2.g17667.t1"/>
        <property type="gene ID" value="PSU_v2.g17667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17667.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8481" checksum="E6BCF676E97891F8" modified="2023-02-22" version="1">MDKFTKDQVQNAHYGTTLFNIFSFLLFLIYCILQNKNRIMGLIVEGRGGRPNGRRGASVRYRRLNTDDAEAGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBW7</accession>
    <name>A0A914YBW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBW7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16253.t1">
        <property type="protein sequence ID" value="PSU_v2.g16253.t1"/>
        <property type="gene ID" value="PSU_v2.g16253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16253.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7776" checksum="B3C0027EC55931F9" modified="2023-02-22" version="1">MSKTISNEVKQEFVETRSEKNQQQVTDKRNGSKKELAGDEEMPEEMEFGCPHNVYDKITNIRSNCTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCK8</accession>
    <name>A0A914YCK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17161.t1">
        <property type="protein sequence ID" value="PSU_v2.g17161.t1"/>
        <property type="gene ID" value="PSU_v2.g17161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17161.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="13014" checksum="CF9C9A36D8544E13" modified="2023-02-22" version="1">MGGGGGCCPPPAPCCPPPPAPCGGGCGAALPPPPCGGGCGGGLPPPPAPCGGGCGGGFGGAAPIGGGYASAPSFGGFPQQQQGGGGYAQAPQQFAPQQQQFAPQQQSYAAPQQAAPQQFAPQQSYSSGPSGGGGYVTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD35</accession>
    <name>A0A914YD35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18136.t1">
        <property type="protein sequence ID" value="PSU_v2.g18136.t1"/>
        <property type="gene ID" value="PSU_v2.g18136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851:SF5">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18136.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19326" checksum="CA27736B5C48840D" modified="2023-02-22" version="1">MEDQIFNPEDPKFKCCCGCCHVTTGTKIICILSLIGTTAVIVPFVGLHPSPEIIGLGITLFLVSIFIFISPFFGIKKRNPNMLIPLLVILGIGVIYVVTKNVLGVIDFLSNPETPQTWPFESKPDTRYAVVLAAFIVKAVVSIALNLWYFFIAFRCYQYLTLKNKAEILPMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDR0</accession>
    <name>A0A914YDR0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="7">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 7">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YDR0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16892.t1">
        <property type="protein sequence ID" value="PSU_v2.g16892.t1"/>
        <property type="gene ID" value="PSU_v2.g16892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000092">
        <property type="entry name" value="Leucine carboxyl methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF33">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16892.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38928" checksum="10177F051DD1CBEF" modified="2023-02-22" version="1">MDGEADIGDGQLGAEIGLRRRSASVSDDYSVQKTNDDATESKYAAVKLNYWYDNFIDHFAHGVHKRDPEISCGYWARVATVTSFAQQFIEMNNSKCQIINLGAGFDTLFWRLKENNFKVHRFIEIDFSSVTAKKIRHIRKPQRDPKLFSFFDGEPTESQHSDLHAGDYHLIGADLRQLAELEQKLNSTEIDYKLPTLVISECVLIYMSTESSSALLKFFSSKFNSIAFLNYEQVNTADKFGEVMLSNLKSRGIMLPGLSVCDNIETQKQRFVENGFEKVNAWTVMEIYRNHFNPEEVKRVEDIERLDEKELLTQLLEHYSFVYAFKGSSGNSDLSSIKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEE4</accession>
    <name>A0A914YEE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Queuosine biosynthesis protein QueH</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17817.t1">
        <property type="protein sequence ID" value="PSU_v2.g17817.t1"/>
        <property type="gene ID" value="PSU_v2.g17817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:tRNA queuosine(34) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003828">
        <property type="entry name" value="QueH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36701">
        <property type="entry name" value="EPOXYQUEUOSINE REDUCTASE QUEH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36701:SF1">
        <property type="entry name" value="EPOXYQUEUOSINE REDUCTASE QUEH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02677">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17817.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14973" checksum="106FC2812213BB08" modified="2023-02-22" version="1">MERADAASAARCARHALRRTALYAHEHGYDTISSSLGISRWKNMAQINDCGIRAASRYEGLQYWDYNWRKGGGASRMIEISKREQFYQQEYCGCVYSLRDANLHRRESGRERIRIGLLYYGQDAEAPQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEU3</accession>
    <name>A0A914YEU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEU3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1782.t1">
        <property type="protein sequence ID" value="PSU_v2.g1782.t1"/>
        <property type="gene ID" value="PSU_v2.g1782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF546">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="8"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1782.t1"/>
        </source>
    </evidence>
    <sequence length="990" mass="112283" checksum="207C1AF1DD53347E" modified="2023-02-22" version="1">MTPLLSSTVKVVLRIKKEAKSKSNKLHVEKKSDGKDCVMVNHDALHIFPFDKALNQCATQLDTYNAVIGNGIDLFLSGYHVSVFAYGQTGSGKTYSITGIENQPGILPLFAKNLFEKISRQNLDSSVYISLSFYEVYQEKVFDLLASNRKPLRVRGGTDDPYVEGLIEVGVKDEDELEKWRRTGLLRRSTAATLMNELSSRSHAIFSLKVQREYENPKRVVVSRCFFVDLAGSERLQTSGGHRTNESISINKSLLSLQRVVDARASNEAFVCYRDSVLTRLLKNCFDGNSATTLLTTVSPLECYSSETLNTLRFASKAAQVIQQPTINEEFGGESIADLRELNNHHLKKIAEMSAQIETLKQHCASVESVQAPAVLELFQDESLNQWARLENGIKFCILQNQLAEYFFENDKWNIRAFAAGVFVNGIALTVNSSRQLDHGDILSYYERKFCAVYLDEKCDPNKFISYDRAKLQYVTAVYEKQKEEMTEEIIAESKQNVKDVRDSLENELVSLRKELDGVKNKLKNKSEDQKYALKKEYDMVESLINDTEDVKKNLNDAVSKQTAIFKAVKEETEEDKMMHVGIKKVYAELNNEKFVELYEYFADLYQSDKTADEIIGEFNRFLYSSKYVWKPIRSGVGSSLLQTAVFNTLQETARKRRSTYAEVSRGFASRRSVIADIIQKPSERPTSQPIDELVQSLSFYALTAQRGPDTEEELGKLNEIGILLNVCITVRKNFDVFIAPENFLTAASIQKKAASIVGIYRSIGSLDALAATAQLCFITPSIADISLDYCPKEILERVNCLRQLIESWINAVREDTLSKDLGNLIFNEIDRIIQSVGFLAYFLGRRVEITDPGVQNEFRKGIMSAVKDLTMDVPEILERCDGEKTTREKFKKLAATFVSEILKYVEQSFDEDFIFEVVRRAILIKENMITLTEDRAGKMVEKIKDLIKNIEKFSTFVNPSSIELLKDGLKMWQQLSYISAKPPKSRAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEU8</accession>
    <name>A0A914YEU8_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEU8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17825.t1">
        <property type="protein sequence ID" value="PSU_v2.g17825.t1"/>
        <property type="gene ID" value="PSU_v2.g17825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037961962" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17825.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12793" checksum="14D6456732A92653" modified="2023-02-22" version="1">MKQLFIIGLFYVAFAAGIEAERRLTISGRIFCCYKEISGGSLCSVIRHAKIELMNEFSLSPDQVLHTFEPHDTSTYVFTWSGKSFFKFKPYLNVHVECDGGVTSDKKYSFGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHB3</accession>
    <name>A0A914YHB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18856.t1">
        <property type="protein sequence ID" value="PSU_v2.g18856.t1"/>
        <property type="gene ID" value="PSU_v2.g18856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057085">
        <property type="entry name" value="Ig_Irg-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053295">
        <property type="entry name" value="Innate_immunity_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324">
        <property type="entry name" value="PROTEIN IRG-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24415">
        <property type="entry name" value="Ig_Irg-7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18856.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32215" checksum="965B115B0F3AF36E" modified="2023-02-22" version="1">MINHLGLGAVYLRSNRSNSFDFTSVLSPRYSCNYEYYAGYFTCQFGSTYQWVVDGVDGYGYRFRRSSDFHCLNPPVTQGPPTTSVVPPSACLNGGTFVNSTSTPFCYCGTFFTGPTCAERVCMHNGNPTANGCDCSPGYTGPFCEHISCNTDVFGGFNTDEKTLIVVIRQSPFIAQQVNYIAQAIQEQINYHAVNDATVYSWFILVSFSNDNIKWQEYSTSTDFLTNLVMLNTTNVQTGCNDTVIDAIASVFEVEAISAKSPIIVITDAPPDDGADYLTVVNRNTYRKLPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHD1</accession>
    <name>A0A914YHD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHD1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16719.t1">
        <property type="protein sequence ID" value="PSU_v2.g16719.t1"/>
        <property type="gene ID" value="PSU_v2.g16719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16719.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="51115" checksum="B2B4975981CEFAF8" modified="2023-02-22" version="1">MENITLVSDLAWISRGVAKKEPVKLQLEKTQLAELIQGDGESEGDTSEEDDQEMDMEDKPKEANEQKEDKSTEKKTDSKKEGNIMKGVAVHASSKDDPYITKQEDSEDEYERDDFVLKDTDNLVVVAKMVKDEPSIDVHVFNDSTGDWYLHHDYILPSPPLCLASIRYDPGSEDQKKRGNLLAVGTFEPTIQIWDLDIANALEPIVTLGQQAKSSKGGKSRKKRDNSAQGHSDAVTALDWNQLCPHVLASGSADQTVVLWDLDEAKPATIITCFDDKIGSLQWHPVETSILVAGTRAGKAQVIDCRNTEPVSNAQWDMGAEIEKLLWDTYNPFCLFATTDDGKLHYLDSRKPGTPVTSIFAHEDGANSVSQNYGVRGMIATVGENELKIWKLSGAKPTFEEVYQHEIKMGKLFCVAFCPDVHNTLVIGGEAEEMIRIVDLEKYEKVCVAFGAKSAEEAMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI93</accession>
    <name>A0A914YI93_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YI93"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20054.t1">
        <property type="protein sequence ID" value="PSU_v2.g20054.t1"/>
        <property type="gene ID" value="PSU_v2.g20054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20054.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42206" checksum="440CC6C779383A10" modified="2023-02-22" version="1">MPKSKRDKEISLTKVKKKTRENKNAVINRIQDALAQHKNIFVFSIDSMRSTKMTEIRQKFKETSRFFYGKNTVMSVALGRDAATEKEKGLHKVSQLLKGQCGLMFTNENGKNVIKFFKEYSENDHARAGQEVDEDISLEKGPLPQFAFSVEPQLRKLGLPTKLEKGVIELVDDFTVCKAGDKLNPEQAKILKLLDHKLSHFQVNLIAHWSADKGLTTLYYDTSANTFFKASTTAAFFSTTTKCLKEVGKREIRFSETAAYQGVDRRSFDLKSEWKPDYYQTHSYRTKKLLSALLSLTAVIIWIGCIREESDLDAIFNTPPHLITAGLERKMLKEQIQKNKRDGKDTSLLQAELEYVDVKEAALKAQFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIQ2</accession>
    <name>A0A914YIQ2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Profilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIQ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1939.t1">
        <property type="protein sequence ID" value="PSU_v2.g1939.t1"/>
        <property type="gene ID" value="PSU_v2.g1939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1939.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14828" checksum="9BE38171F78FEA54" modified="2023-02-22" version="1">MQPWQNFVDWTSYLSSRLHAKRNEIRRAAIVGTDGCVWARSEGANEFRPTESEMKSFVRHFTNLINVPANGADLEGVHYALTVNSGVIRGIGEEVDFFAMTNHSVIFIIFCNQSTYQDAMDTLAAFDNDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJD7</accession>
    <name>A0A914YJD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20455.t1">
        <property type="protein sequence ID" value="PSU_v2.g20455.t1"/>
        <property type="gene ID" value="PSU_v2.g20455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20455.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9691" checksum="F7252D8502FF8411" modified="2023-02-22" version="1">MGPVVGIVGNIQAIEIMKFCAFGESSYSDVMYNYDAFDGRFFNVKLRPKSPNCESCIVGLTQVNDYQMLCDRIAGETLYGKHILAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK59</accession>
    <name>A0A914YK59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secretin/TonB short N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK59"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20728.t1">
        <property type="protein sequence ID" value="PSU_v2.g20728.t1"/>
        <property type="gene ID" value="PSU_v2.g20728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051808">
        <property type="entry name" value="Type_IV_pilus_biogenesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30604:SF1">
        <property type="entry name" value="DNA UTILIZATION PROTEIN HOFQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30604">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN HOFQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Secretin/TonB short N-terminal" evidence="4">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20728.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15364" checksum="A090BB76BFB0EA47" modified="2023-02-22" version="1">MNVTDFATPVQRIDAKPSGAGTQLVLSTGGAVESLAYQSGNEYVVEISPRQAQAAVGAVTAGSVTQAAKAVGQRGFTGKPVTFNFQDVPVRTVLQLIAEESNLNVVASDSVQGNVTLRLVNVPWDQALDIVLRAKGLDKRRDGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK69</accession>
    <name>A0A914YK69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SWI5-dependent HO expression protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK69"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2074.t1">
        <property type="protein sequence ID" value="PSU_v2.g2074.t1"/>
        <property type="gene ID" value="PSU_v2.g2074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055167">
        <property type="entry name" value="Rootletin-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15035">
        <property type="entry name" value="Rootletin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rootletin-like coiled-coil" evidence="4">
        <location>
            <begin position="31"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="224"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2074.t1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44702" checksum="2F233F61858D43DA" modified="2023-02-22" version="1">MLSDSELDRATTSNEKANELKRVPSDLIKYRKRIDSSVQEQRKFREILENLQSKVQKYRQKAAEAEVEAINNSARGLGHGQSFPSLLHGNDSIGGNDNLWNQNPSTSGDYGFSQSTPGLLHAQANYRAAGSNPILSSTRSPNNQRRIQFAESSDNFNPESDPTVNLYQQRLKEEQYRNTILEEMIDTLKRQGESTSHTNESLTNDLLTLHETLTRAEQSRLRSSEVFKQREQKLKREKQLLQRQYYDVSMEIGTLRRKINELKSETESDLQNYKADFDRCTKTMENRLKHHETLRTTTFQRTAKEHDNAFEEVMKRYDDAVNKSLQNEHERNEVSRKVIFLESALKRAQEEKEQIEDSLKKIHQLPEVAEALGRRTRSVSPGKQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKA6</accession>
    <name>A0A914YKA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKA6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20773.t1">
        <property type="protein sequence ID" value="PSU_v2.g20773.t1"/>
        <property type="gene ID" value="PSU_v2.g20773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20773.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7882" checksum="99464CDF952D9B1C" modified="2023-02-22" version="1">MALEMVDYLFPPLHYPFTKSETCSTLTYWRTAPSKTVLNESELDEYERKRKEMAKKNNKKCAKWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKN1</accession>
    <name>A0A914YKN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19434.t1">
        <property type="protein sequence ID" value="PSU_v2.g19434.t1"/>
        <property type="gene ID" value="PSU_v2.g19434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37976">
        <property type="entry name" value="PROTEIN CBG16927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37976:SF3">
        <property type="entry name" value="PROTEIN CBG16927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037754956" evidence="2">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19434.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27009" checksum="9748ABABF9D3193F" modified="2023-02-22" version="1">MTLRPLIIVAVCLFVTNLAEINVKIERHFPCSPSSGPSKENLRIKFPSYKSTGVNFHEEKNDQGHKCFRMSGGNVEIFPPGLDGSKKYYVHLETRIGIHGKPERCVNADKDGCGGIGSCVHCDICKNMGGALKNFVQIYQKDAPAKCSVDGLTAGDYDDLSLKVCLPTKTELLPFLDSNPTRAQQLWDLFVSSRARSGEIPLVVAARIFDRPINKLSIKELNDALHGSKKGMIGCHWIYATISQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLW4</accession>
    <name>A0A914YLW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U3 small nucleolar RNA-associated protein 20 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLW4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20558.t1">
        <property type="protein sequence ID" value="PSU_v2.g20558.t1"/>
        <property type="gene ID" value="PSU_v2.g20558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20558.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15444" checksum="99B02B559C2E388C" modified="2023-02-22" version="1">MFLLSEFVEDSEVGEHFASTLLSYIENDRIKNEEKITAVLQTISSLVGFVKEPKSYLRRIPRLITSINYRASREALISIVSALSKHSKLSAEKSFIENLKILEDLEAWDKKKLNEPDQERRHQALADLDRVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM11</accession>
    <name>A0A914YM11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21365.t1">
        <property type="protein sequence ID" value="PSU_v2.g21365.t1"/>
        <property type="gene ID" value="PSU_v2.g21365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21365.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26613" checksum="1C347029CDDA0AA8" modified="2023-02-22" version="1">MAVAEAGDLEALDLAPRQIRHVDVEDGVSRQRIGLEPGNDLHRSARGGLEMFRIVVAGNQRDRHRRQPEEATFHRRRDGAGVDHVIAEVGGIVDAGHDNVRFELEQPGQRQVHAVGRSAGHRDGVMVDALEADRQVQGQRIAGAGAITVGRDHRDLVSGLAQHRSKHPDACGVDAIVVTDQDSHLRFNRLIFQEFDSVTVQCGRDRRTPLRKPSTLQGHRLLCRMRAAGPTLSAVMTDIEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN12</accession>
    <name>A0A914YN12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YN12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20333.t1">
        <property type="protein sequence ID" value="PSU_v2.g20333.t1"/>
        <property type="gene ID" value="PSU_v2.g20333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20333.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12738" checksum="DE9B58F1963B8963" modified="2023-02-22" version="1">MPLDKNEDESEFTIVQVGGEQARIVGNRGGLDPKDTAVYACRYLWAIQLSDAEPVRFIKVDEEGEEVAWTETLEELLPFALSEDAFAVEDDTDEDDEDDDDDSLEPGVHGHTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNM2</accession>
    <name>A0A914YNM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18948.t1">
        <property type="protein sequence ID" value="PSU_v2.g18948.t1"/>
        <property type="gene ID" value="PSU_v2.g18948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018724">
        <property type="entry name" value="2OG-Fe_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10014">
        <property type="entry name" value="2OG-Fe_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18948.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28028" checksum="EE9AAFF3AA79A4FB" modified="2023-02-22" version="1">MAPNLKDDINSIKSGIQNENEIKDYDCKLKELNNEIAKDDATSDALNQLNNDGFAYIKIDFYGFETNCTEIEELKTTYDSLPIDPSPGNRYRAYTCYDWNPTEQSLKKQDSTQYFQSKEYNYIDGGNIRIFDPISTTFLENSVLKGLIQKDTELAKKTGIINFDETFELGLHQIRYKAQGIEPAYSSPLWLHRDDEPLVFVHLFNLSDNAIGGNNLIATSPKAITHIIQLKSPLETILLSKRIITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQE4</accession>
    <name>A0A914YQE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19585.t1">
        <property type="protein sequence ID" value="PSU_v2.g19585.t1"/>
        <property type="gene ID" value="PSU_v2.g19585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="87"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19585.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="33815" checksum="2B255D81F7983E8B" modified="2023-02-22" version="1">MAFETTVITTDVIEVPAEAKTIVINPPSDGSIVPPVTTNGDATVVAPVTTTTEAETPVAEKPEEKKVVNPREDPVEWIKSLIPAGVHKVNHQILSWIQDQTYTDETQKQPLPGKNESVTKTQFINFLKDGTLLANFANALSPGSIEKVYEGEEAKVKENQKANLQNFVNFAKEKAGFTEAEAFAVDDLQENGKSGYNAVFNTLFQLGMKAQEKFNATGIDVENVMEAASTAVKNSIIQTIWNFFKRVRPQLKSKAETSDEKTPTVNGANGNGVIIEETPVSNVVPIVASNGDAKVVEDIPPPVPTTAAPAVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR37</accession>
    <name>A0A914YR37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP synthase F0 subunit 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR37"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21541.t1">
        <property type="protein sequence ID" value="PSU_v2.g21541.t1"/>
        <property type="gene ID" value="PSU_v2.g21541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21541.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11243" checksum="145107E84DE5D511" modified="2023-02-22" version="1">MQYGKYVPLLVVAVTAVFTSAIWVGAYYIGVKPNESNSTPKDSTQTNTNNTNTVSKPTPISKTTCETSCDFRLVESIPWGLKFNDGKIWNTTASAWMELMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRB8</accession>
    <name>A0A914YRB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3308.t1">
        <property type="protein sequence ID" value="PSU_v2.g3308.t1"/>
        <property type="gene ID" value="PSU_v2.g3308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070569">
        <property type="term" value="F:uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3308.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10067" checksum="27F260B2FC3DE8F6" modified="2023-02-22" version="1">MCLHNIASCGKFSTDRTISENATEIWGVKPNAISLQAPYEGVEDLKANDPEAYYPPGHGNFYEAFYNSGLLQKFIDQGKEYIFLSNTVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSP7</accession>
    <name>A0A914YSP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20442.t1">
        <property type="protein sequence ID" value="PSU_v2.g20442.t1"/>
        <property type="gene ID" value="PSU_v2.g20442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000082">
        <property type="entry name" value="Putative zinc finger E-box-binding homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20442.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10194" checksum="93C881851AE1EC3B" modified="2023-02-22" version="1">MSAAVEFSPAENTLDCQLAALLNGGGEISDKASTASSASTTTDQVERKFKCSECTKAFKFKHHLKEHIRIHSGEKPFEVSLNTLKQQINLFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSR3</accession>
    <name>A0A914YSR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSR3"/>
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    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Coils"/>
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        <source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20462.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39428" checksum="B27134E8165F8567" modified="2023-02-22" version="1">MENNNDQTSVSALLEEIENFRIKNQELEKSVKLANTTSFNAKMSAATTSRELEAIQRELSQAKEYKNAYEKQEREIELLKTENQRLQTAASLRTTPTASTISSCSSRRMPHTNPPSTIPQMQPTCLTLPTTPQPYATPQCIPLNQSINSSLIERKMLESNAPTPIPRKLPITSSVSSMPASPAFGDINDQGLINYDKEENRFPNEEFDDDVSSKTTLSQISFSSCSSTEMSQIYHPPIQSSECLQAPIPSAPKNFVLKTVTLKKVVANDTIECSSYSEQIDDDMDSDDFYTDYGSSEDGYQDELKEHDKIQMISGSVVPPKSVAPLNDEPEYTDEEDAYEMNHYVGLGFWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU30</accession>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
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        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF66">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML66"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal protein S18"/>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20968.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19856" checksum="13D12579C95ABB5B" modified="2023-02-22" version="1">MHRRLGTTSLCKAKKIVEKTDGNVTIIEVENVEESQKPKVELGKHSCALCALPMKIKYTDVLILEQFMREDGTVLPKQITGICPKQQYRLERCVMQAHWAGLFPDKTLPDFDRAGYKRFNRYWDDDWDMYKTQVKVKAGSWFYVHQHRPRAPLFTIGNKNFEQSKETSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU61</accession>
    <name>A0A914YU61_9BILA</name>
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        <submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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            <begin position="51"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="435"/>
            <end position="589"/>
        </location>
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        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3529.t1"/>
        </source>
    </evidence>
    <sequence length="823" mass="97524" checksum="9ECC38ECD41783FC" modified="2023-02-22" version="1">MKRRQTFDDDEMLDEKHQRQSSLNGSPVRSENIGPTKTVVTDINPNIYADYIKLNENYSDLECKYSEAMSRLAEFEQTKYEDEEAVNAVTEELDKTNKKADEVEAEMANVIKKIEAVELLNKNLQETVAEFQKINEKIENDAEEQRVSFQSKIDDLQNELENERISSAQNLENLRVEYELKALQNKSEGVEILAAKELEHQKVEYEFKAQEQLTSLQNIIDELQIQLKEQKSTSSKELEQQKMEYEMENKKQFSSLQNKFDDLQRKLEEQQTSASQEKENLRVDYELKAEDQRASFQSKIDDLQRELAKEKTSGSIQIKNQRIEYELKAKEQLISLQNKLNDLQYKSEQEEISTAKEFEQQKMEYELKAQEQVTSLQNTVNDLQSQLVEQKSTSSKEFQNQKAEYELKAQDQLISLQNIIDGFQRQSEGEEILAAKELEQQKMEYELKAQEQITSLQNIIDELQIQLKEQKAAFRKEFEQQKMEYEMEIKKQLSSLQNNFDNLLRKLEEQRNSGYHELQKQRIEFEAKVQEQRASFQNKIDDLQRLSEEEKATTYREKENQRVKYEEQLIFLQNKLDYLQRELEEQRVTSDQELQARYDDKIYNEVKKNSQEEIATNESLNKFNESELKNSQLSKIYEPKWFILKAICYSLYKSYGNKVAKFLQEYTSLLFNSVEVMLPEEKLNKEKWDECIAVIFWFWKPQNDYQKELCIAASKKKMEERRNFARNAAFKNCTFNRCVAFTSAGKKFYYSLRKYDTWKPVANKECKKVLKYKSTLHSSFCIPIQYTSSEYIIIFQDSPDDGKKIFKMLPSGYTECIFYENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUU0</accession>
    <name>A0A914YUU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
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    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
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            <name>heme</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="gene ID" value="PSU_v2.g3437"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:organic acid metabolic process"/>
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    </dbReference>
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        <property type="term" value="P:xenobiotic metabolic process"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3437.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19124" checksum="3C4AB947C6A936F1" modified="2023-02-22" version="1">MPFFRDKQLYAACLDLWIAGQETTSNTLAWMVMYLMLNPEVQKKVHAELDQVIGSDRFITVEDKTQLHYINATVAETQRFCNLVPLNVNHRLVKDVEIKGFRIPANTTILHQISTVLFDERYFPEPLKFKPERFLDSEGKFFQPSSLMPFGVGKRACLGEGLARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV71</accession>
    <name>A0A914YV71_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transmembrane protein 107</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YV71"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4041.t1">
        <property type="protein sequence ID" value="PSU_v2.g4041.t1"/>
        <property type="gene ID" value="PSU_v2.g4041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029248">
        <property type="entry name" value="TMEM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34341">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34341:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14995">
        <property type="entry name" value="TMEM107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4041.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14034" checksum="F68AD90BAA0B01D9" modified="2023-02-22" version="1">MARATILFCAIFDKTEFVYASLPFGEALKQEVEDYDASITVCLALSLIFAILEIVFMFRQIPSVFVSCYSLLSHVISSIFLCKFTVDYHPVSHFWIVFGFGSCPTLMLQLFIFANSFNKRKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVG0</accession>
    <name>A0A914YVG0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YVG0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3649.t1">
        <property type="protein sequence ID" value="PSU_v2.g3649.t1"/>
        <property type="gene ID" value="PSU_v2.g3649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009266">
        <property type="term" value="P:response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042330">
        <property type="term" value="P:taxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000035">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF498">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3649.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23377" checksum="FD623FF23369BCE7" modified="2023-02-22" version="1">MIPKDVARDLKLGRPVIPRGFDSSSVLFTDIVSFTTICSKSSPMEIVNFLNDLFTGYDAIISQTDAYKVETIGDAYLVVSGVPNENGTENVKVIATIALQMRQYLSLYKLPHIPDFKMEARWGLHSGPVAAGVVGLIAPRYCLFGDTVNMASRMESTSEAGKIQTSLEFHAGLSSRKDPFITEKRGTITVKGKGECLTYWLVRAATDEGQSQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWW3</accession>
    <name>A0A914YWW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TFIIS N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWW3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2568.t1">
        <property type="protein sequence ID" value="PSU_v2.g2568.t1"/>
        <property type="gene ID" value="PSU_v2.g2568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042376">
        <property type="entry name" value="MED26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201">
        <property type="entry name" value="CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2568.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="29409" checksum="711757EF49DAC257" modified="2023-02-22" version="1">MVVMARTLATHPDLSGSLSLSPIPHLVDQLKAELISAADNNEESSGISICNKLEKLNLSKEHLEGTRIGGIVNDVRKRVAESMPKFSNSCRSLIKQWRKQTETYTRSASSNGGSNGVTPSMMACSPAMRRLVTPQTPHRLSDGSITKSQVSSPRVPGNLTPAPSLNGIHGSSNDLVTQAFEKVQLQNGTDSGKASLKRKTETNISPTEGPPAFKRSKSALIQQQVASPLLSLSAVRQNAQSTTELVAQLSENLPSHLIPSLDVPKSNSTSPNVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWW9</accession>
    <name>A0A914YWW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWW9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g46.t1">
        <property type="protein sequence ID" value="PSU_v2.g46.t1"/>
        <property type="gene ID" value="PSU_v2.g46"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g46.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18101" checksum="5E9CCA03308D2C18" modified="2023-02-22" version="1">MINSTASKFGEYFKYDENLPCEFDNSEMKFLASVECESMINCESGKEYHSNSKYSHPIYGLNRTCEACMKFICTSDNGKTVNNGYGCYEDFERACNFLDSDIKEKIKINIKDSFYYDKNYVVISCSDSDNCQLSIDSLLPYAQVVGKMFLFVFVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX30</accession>
    <name>A0A914YX30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4206.t1">
        <property type="protein sequence ID" value="PSU_v2.g4206.t1"/>
        <property type="gene ID" value="PSU_v2.g4206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF58">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4206.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8237" checksum="53F2842B5E9322DB" modified="2023-02-22" version="1">MASPFYFHIPYQSDCQVRRERLQDPRGISYNVVVIVQHHRLFVTAADKAYSVSCFYRDTQTNLEKQLEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXQ5</accession>
    <name>A0A914YXQ5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914YXQ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2868.t1">
        <property type="protein sequence ID" value="PSU_v2.g2868.t1"/>
        <property type="gene ID" value="PSU_v2.g2868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="14">
        <location>
            <begin position="79"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="13">
        <location>
            <begin position="306"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2868.t1"/>
        </source>
    </evidence>
    <sequence length="786" mass="90789" checksum="1AE7315F1589D61D" modified="2023-02-22" version="1">MRKRNVKPSQKTNQNDSVQYEKAARAKETQILAYSIPAAIVLTGILVFYITNYGSTVFILEKSNLPNASLPNAYDPNAWGSYRPHVYFGLKTRKPASPLVGLVWYRQALGSVDRFRHGCRQEDNIRYMWQDSDGETFGHQRVIDNELTFDTNWLGFKHSFASEIKLHPISQKIPNAKYTFVFYFYLENESDTLYPEVGSDGQVKSYIGNIDGIGKYRIRFESNNPVTSEASFKVPPTFNLVSITDVVQGITDVNDEGTFFINQAKLGQNLENSDSRQLLFVQFTVAENDVVRMHFEGNEEQLEGKFGDVFNKKLENFRKTFDEKYELKQTNYPANYEMMGRAALSNMLGSIGYWHGYSEVDSGDSVKPYGPLSLLSGVPSRPFFPRGFLWDEGFHNLLIKNFNPSLTLNILSSWLDSMTSTGWIPREMILDPEARSKVPAEFITQHPDVANPPMFFYVIESLMRSTDFMTQYSRRLVQFYPRLKQFYLWLKETQKGPKKGTFRWRGRNGTTDLELNPKTLPSGLDDFPRASHPTNDEYHLDLLCWMALSSRVLRQIAEYASDTAFMPEIEEDMELFNSIENLDKHHWSESKQRYFDYGFHSENVALKEIRFQDKNGQIHVIKKRDVKSPPKLQLVENVYGYLNLFPFLLRLLHPTSDKLGIILKDLKKEELWTPYGLRSTSSNSPYYMRYNTQHDGPYWRGPIWINMNYLALASLKHYSASGPHSEVARNLYSELRQNVITNIATQYQATGHFWEHYNDKTGKGAGSHPFTGWTALVLNIMAEKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZR7</accession>
    <name>A0A914YZR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZR7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5426.t1">
        <property type="protein sequence ID" value="PSU_v2.g5426.t1"/>
        <property type="gene ID" value="PSU_v2.g5426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5426.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15799" checksum="78DC21A34E7842F2" modified="2023-02-22" version="1">MEEHNVYFVEKLVEACQKGHVQSLIHLSSIFLQCTSLFPNVNSREAKPLDSKFVPFKPYVDTKRRAEDLLMNHDCDLQIVIGRCGGIYGEGDVSSPICDAICLIDKLGYLPILGDRGGVYQVSNHIYIVKYSTFLDNVCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZS4</accession>
    <name>A0A914YZS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZS4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3532.t1">
        <property type="protein sequence ID" value="PSU_v2.g3532.t1"/>
        <property type="gene ID" value="PSU_v2.g3532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401:SF3">
        <property type="entry name" value="DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036857180" evidence="1">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3532.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25710" checksum="7A1083FE9A04A484" modified="2023-02-22" version="1">MAAFFSFFTFAFIALIYGGVLISCDENANILDSNKTLFLSTTTLKPPSESSISIPTTSTPTTNSPQVEMIRQCSCTESEECITKAWTQISEYQEICKSNLNYFGNDTSKLVKCFINDKSGGKLLNLCVQAFAACAMPKTTPKLISKKLNIPVIRVKEHEMIESLKDFHICAGNFLKDNILQCFNKKNCGVSYIDFEDVGKLGAICPATKGYYYTITVKALPCLKAGVKHVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZT1</accession>
    <name>A0A914YZT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZT1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5608.t1">
        <property type="protein sequence ID" value="PSU_v2.g5608.t1"/>
        <property type="gene ID" value="PSU_v2.g5608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5608.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16774" checksum="311FA60F4299888E" modified="2023-02-22" version="1">MSKRIGPSVWARLWNNMSRMITKETEKIVVGQDAVGNQYYEYKGSRSDRTNIRRGYNQIDPNGMKPAIEWEAWLKGTRRFPPSDEEIQINRLRQQKQLEQDSVTEKRAPKIESSGKGAGDIDRPKQYPTYDDMEHSPGAKKSDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZU0</accession>
    <name>A0A914YZU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5445.t1">
        <property type="protein sequence ID" value="PSU_v2.g5445.t1"/>
        <property type="gene ID" value="PSU_v2.g5445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5445.t1"/>
        </source>
    </evidence>
    <sequence length="438" mass="51122" checksum="91F75EA05CADC93C" modified="2023-02-22" version="1">MYTASYLLSSTGIRFKQNGRHHIRWINDVKPARGGLNPRIIKERAEQVFQLLSNQIKNLVIVNGNLSDFEMIEACVEVAEKHTKNIMVIPPLLSRMTYAIEDISKMHNPPPNEVIMVLTVTNAFVDFVILQRDRNFELNIIQREIFKYTNACMKEFLRFYEYYNPDATVVLVHDDFLQLVDDIRDEFRPQNFFWRHFKRWDYLLMFGALARATDDDADFDRRYRIPNFTMGIETIIPGLRLGCNFVIHPERTKIPCKIYGFQGKPQPITLFYFPEYYLFFDKLTLERKDASTKCIWITGSSDQVIGYYDERGVPYITATKDHQEDIKKEPDKMPANKEPIERTINSPTSSTAKPMASQITFIFEEELCTVEIYQNNLVQQVKNSDGNEWTPLYFSMAEGTPEIGKKAKNDLQKFPKGVIYDVLKIIGKPMNEIYNLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZZ5</accession>
    <name>A0A914YZZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 25 member 46</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3602.t1">
        <property type="protein sequence ID" value="PSU_v2.g3602.t1"/>
        <property type="gene ID" value="PSU_v2.g3602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039158">
        <property type="entry name" value="SLC25A46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252:SF2">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252">
        <property type="entry name" value="TB1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="263"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3602.t1"/>
        </source>
    </evidence>
    <sequence length="480" mass="53206" checksum="9A329AE722E99C52" modified="2023-02-22" version="1">MSHHSAQGPPPEYARGYSYPPTYSVSTRDTYNDPNVVQAAEAAAVAARTDDPLSNLALSVGNFINKVFISHPCTVIRGSCQIHQNARRLHLTPVTLVPVVIHMIKKDGILTLWKGFHGYWVVYGVGYVVEIIISDVFGLPKTVVYNGSSEKFLKHVSLKTWTAIVMTPFYISSFIETVRSGSGLKFSESNILDVIYRGFDRVRYDLFGGIDSGRKLPVIYLAAPTVTYVVSHYLISRWAYNSIYSMARRYVLRKAPQERTRFHSILPDLFAAMTSSLAADLICYPIETVLHRLYIQGTRTLIDNLDNGVSAISINAKYNGFFDCFSSILKNEGFMAFYAGVGAIALQYCLQFCVVRGIRYIFEHTIQAPQVNVNHPVIRSGPTSQVAHPSAQFAATETPIGQAKSPTTPNKSIYPTFAQTSANIDVPPLGQIFNNFNETSNPFGGSTSPPIFPSPNRHQNDFLLSARTDTPNSDLHNEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z007</accession>
    <name>A0A914Z007_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z007"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6080.t1">
        <property type="protein sequence ID" value="PSU_v2.g6080.t1"/>
        <property type="gene ID" value="PSU_v2.g6080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="158"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6080.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40842" checksum="BB70A6119CF8A928" modified="2023-02-22" version="1">MEFESVLGKSRYTVAWIIQKLKESDEKFRILESKNKILKIEETNLSGIGYMSFIIRLTFYFGNNDNNEERNDKTFKVICKIPTTDMIYKNFKRSSENNHSKNGTNHNKKSNELKEFLTKAHNRECFVYSSIVSNLGIKVPKIYFFEEKNDERERDGCIVMEDISEKGALQNVLKEINYQQVEAVIKSIAKMHAKSQTLPQKFFQNLKFDNIIKVPKDCLKGITKLESKIIQKYKIELEEIWEQEEEIVDSHLKYGIPSVVSHGDCWINNIFFYKNESGKASNEFYTLLDWQLTHRGNGLNDIARFLTVSVEAEMLEKHRSDFLQIYYKSFNEKCLYIFMKTYIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z065</accession>
    <name>A0A914Z065_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z065"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3669.t1">
        <property type="protein sequence ID" value="PSU_v2.g3669.t1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="ZGC:101858"/>
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        <property type="entry name" value="adh_short_C2"/>
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        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="SDRFAMILY"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3669.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28024" checksum="4ECDDBABDCAB3E42" modified="2023-02-22" version="1">MASANRFEGKVVVVTGSSAGIGRASILRFAKEGASVVVHGQSKEKLESVKKDLLGLKVDESRILVIAGSLEDEATQNRLIDETVKRFGRLDILINNAAIPGKAGCDPNSMEGFDAVMIVNVRAIYRLIQLATPHLEKTKGSIVNITSDLSERPMTGSMPYSISKAALNHLTRNFARLLAEKNIRVNAVGAGLTETDFITRMGMPKEAITHIFTEVAKTIPLQRASNADEQAEMIVNIASPTNTYMTGSIVFNDGGIRIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z069</accession>
    <name>A0A914Z069_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z069"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3674.t1">
        <property type="protein sequence ID" value="PSU_v2.g3674.t1"/>
        <property type="gene ID" value="PSU_v2.g3674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3674.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14871" checksum="AE6223242B4B096C" modified="2023-02-22" version="1">METQYNLQYGARLRHFQVHDHVWARKRKDTPWFEAIITTCCGSRMFDVSDASGKNYRLHTNQLLKRYLLDETHDLDAPLPASNSTSEVSPTTNQPSPPHTPQTSPRRSTRTRKAPTRINIDPKKKSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0I8</accession>
    <name>A0A914Z0I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0I8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6247.t1">
        <property type="protein sequence ID" value="PSU_v2.g6247.t1"/>
        <property type="gene ID" value="PSU_v2.g6247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6247.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37357" checksum="2E0FCEA860D4E440" modified="2023-02-22" version="1">MIIDKLGSTKKVVNLTKNIFNYISQAIVGKALKLHKKQASKFDVANTGFKDFGIGTSEVIQYMMTNFQPPKEYMKKFLIKIASNEIVPIKKTFVNFEKFDNLMTLEGGTNRGFTGFSQYCAPELGLVVSLSVNDRFMPEIDIHKLSCHPHGNKLVDNVAMICFNENMFTVATIKDGKFNKIVLNNEPYLIAFMDDRIHIGKDAEKLKEEYNSFVVSDLLKILKTPSKDLKADPKWGFQISQINDETVLEFDTFKGRRKASPTFLFAFFLRYSVKIIEVISGEMPKTTVIVSKNLNDNFRQQLMASCKSAKINPTNVQIHEYKIVEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z131</accession>
    <name>A0A914Z131_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 7">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Pseudopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z131"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3980.t2">
        <property type="protein sequence ID" value="PSU_v2.g3980.t2"/>
        <property type="gene ID" value="PSU_v2.g3980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051155">
        <property type="entry name" value="Nematode_MSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22920">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22920:SF21">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="9">
        <location>
            <begin position="169"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3980.t2"/>
        </source>
    </evidence>
    <sequence length="287" mass="31307" checksum="8EDF143539082423" modified="2023-02-22" version="1">MLQLNIHHLMLKNFPEGEVKSSRSVKTARTQSDRTASAAASLIGINKSKRENDISENQSITPLITPPPTPAPPAATKKQDDSSRQTRQSLYLPAPGEKAPESPPPPRTPTASLYLPAPGEKTPPPNPMLNDSNYRLSSASNTSLASSAAADAAASISDSSVEGDKNPDDFITIPTKKLVFNSPFDYQALTYHVTVKNNSKKWIAYAIKSNAIPRVTAMPPSGILKPGDKQVIGITVQKFVYYDIDASKDRIAFDYLFCPAETKVFTHSLLQGTATRRRKNIKIEYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Q3</accession>
    <name>A0A914Z1Q3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Q3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6638.t1">
        <property type="protein sequence ID" value="PSU_v2.g6638.t1"/>
        <property type="gene ID" value="PSU_v2.g6638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF3">
        <property type="entry name" value="LD03007P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6638.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28278" checksum="76EB65CBC1E3E120" modified="2023-02-22" version="1">MSGSCGVVNPYMNKRAAKNENYEPTYWEHIANTLTHGIVIIPSILVSNHLVQRSYRDLQHHMMIIYGIATFTLFLMSTLYHLCEFLFRPDKKRLRYYLHITDRVAIYFFIAASSNPWLSLRHSDYLGKNLKWFVWFSAIFGICYQFKFHERFKTVETCMYIVISTIPFAAMATMNDRTGLPLMLLGGAVYAVGVIFFKMDGVIPFAHAIWHAHVVVGASIHTYAIYTVLLGPDKFNPFPNVDFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1X6</accession>
    <name>A0A914Z1X6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5600 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1X6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4256.t1">
        <property type="protein sequence ID" value="PSU_v2.g4256.t1"/>
        <property type="gene ID" value="PSU_v2.g4256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5600" evidence="1">
        <location>
            <begin position="66"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4256.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21343" checksum="1F05CF9123419699" modified="2023-02-22" version="1">MIDHQQLMRVYGALMWSLGKVFKTPETSRVYIGSFWNEPLHYDVNRRLFQDEQHDLFADLQSLPRNAALRKLNDLIKRARLAKVHAHIIAKLREGMPFMIGKEKKKMELIAQLDKIYEKIQREHKIIPGDFPDITKMREHLQDADFAKFNGNKPKLLKVVDEMLATDIGEFFYLFTVVIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z231</accession>
    <name>A0A914Z231_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z231"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6766.t1">
        <property type="protein sequence ID" value="PSU_v2.g6766.t1"/>
        <property type="gene ID" value="PSU_v2.g6766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6766.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18733" checksum="CEA64415237F61F0" modified="2023-02-22" version="1">MPSSAFEIYSNMDVTYFATMAESTVNLLIMVKEPFDHAYDHFNLTLENIPLCKKGAMIGYFQYMSTNNPIQRTFAMAIPMNYETPTFVKDNYQRLISNATTEAINCTFLKKFLRKANTMPHNREQWNLLLIQDPYLSCFSDFDLFWNNTMVSIEVLKIAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z303</accession>
    <name>A0A914Z303_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron/zinc purple acid phosphatase-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z303"/>
    <dbReference type="WBParaSite" id="PSU_v2.g673.t1">
        <property type="protein sequence ID" value="PSU_v2.g673.t1"/>
        <property type="gene ID" value="PSU_v2.g673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF10">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g673.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10524" checksum="7C8F496B48AD5F2F" modified="2023-02-22" version="1">MECRAFENWLVRTGYEEMPGLEKVFIENGMDIGFWGHEHSYERFYPVANRTVYINGKNPYYNAPAPTYIISGSAGCHTPKASFGPPNPASAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3A5</accession>
    <name>A0A914Z3A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3A5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6525.t1">
        <property type="protein sequence ID" value="PSU_v2.g6525.t1"/>
        <property type="gene ID" value="PSU_v2.g6525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6525.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24494" checksum="D4B61AAE3BEDC967" modified="2023-02-22" version="1">MKVRPNSDFKVIVGSIKYGKDGIIHEVEDILVHAGYNKLGDHDITLLKLKTPIIFNDLAKPICITEKFPITFKKVVAIGFGTTATQGSEEFPKTFDNSLKPDFEKDTKENYQIGSHGGICKFVDIPLQKDETCLHLPKNSSVYFVPGLEICGGGLWKGTLEGDSGGPLIGLFQDGYYQIGLTARGQPIAESRGGNPVDFGVYTKISKYCDWISKETKNQVVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4X5</accession>
    <name>A0A914Z4X5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4X5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g703.t1">
        <property type="protein sequence ID" value="PSU_v2.g703.t1"/>
        <property type="gene ID" value="PSU_v2.g703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g703.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19997" checksum="FB5EE9BEE5ECC033" modified="2023-02-22" version="1">MLVFNDSSYEYFLPSDAPEKTTRQSIITFLQTIASDDSVEPMGGRTWPLRFRRMYYDITTNVYQMFQAQPVLTICLFGVPMVFIAVITYSICSADFTVDRDEIYPEEEEYSDSEIIQTNENDATAAAAGKGNIRKRKHKRRESERSLIEDDEEEDGDEDDEEDIDMSDHKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6F7</accession>
    <name>A0A914Z6F7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor-like protein 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6F7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7490.t1">
        <property type="protein sequence ID" value="PSU_v2.g7490.t1"/>
        <property type="gene ID" value="PSU_v2.g7490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7490.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21125" checksum="4135C31681453066" modified="2023-02-22" version="1">MGFVKMLQNLFGNTPKQVEVLILGLDNSGKTTIVNRLKSSENLDSGTVPTVGQNVDKFVAADLTFNTFDMSGQSKYRNLWETHYRTVHGIIFVVDSTDKMRLALARDELWMMLDHRDVAYKKVPLLILANKNDSKDALSATDVHLSLGLDMIRNRNWHIASTCALSGLGLIEAIEWLGVNIKQYIETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6G9</accession>
    <name>A0A914Z6G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6G9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7923.t1">
        <property type="protein sequence ID" value="PSU_v2.g7923.t1"/>
        <property type="gene ID" value="PSU_v2.g7923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7923.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10071" checksum="CCBF70E7459A1638" modified="2023-02-22" version="1">MDSAPSTSGSIPKNLAEDRNFYQVPPNLYEFNEELSGRRSLIVKESSLLNFRKYKAESNDSKFFCCDCYYKNGSKTYANTNFKASKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z728</accession>
    <name>A0A914Z728_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z728"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8499.t1">
        <property type="protein sequence ID" value="PSU_v2.g8499.t1"/>
        <property type="gene ID" value="PSU_v2.g8499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8499.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23402" checksum="D5D6E90FAC837EB4" modified="2023-02-22" version="1">MLLIQAGINEDKILIISGPIQEEKTQKDLIEKTVAKFGNLNILINNVGQSRKPNVADGLDIEHYDYVMNVNVRSVIALTRLAVPYLEKSKGNIVNISSIAALRTSPLTPYYSVAKCALDSYTKNAAVVYGSNGIRVNGINPGTVDTDIWKRSDDPRVTSFRDKLIKETVVARMGKPAEIARVIALLASDDGAFITGSCWLIDGGAMVTPSYFGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z763</accession>
    <name>A0A914Z763_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z763"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8163.t1">
        <property type="protein sequence ID" value="PSU_v2.g8163.t1"/>
        <property type="gene ID" value="PSU_v2.g8163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8163.t1"/>
        </source>
    </evidence>
    <sequence length="398" mass="47289" checksum="EE67802C6A2F162F" modified="2023-02-22" version="1">MHFTSFINEEHWLIGIYKNIVYGIGEEKKGVKELVIYQKTLFDSGEWEIFCELGFKIPPEFYCNVCNDVNMPIAVSILGSDLWMVAIGQVRGDTNECAPFVIKMNFETKEIIIYDATESHLNHYIVDICIKCQCLQITFDTFIQGEKPRYMVASKRVERRKTFAEKYEIRYDSFQWKQFYFVLDEIELTCTFGEYNEFMGIKSLSIIGVDCEKLWFTLRKETHFQYDLQTQETRSFIFDIINYSKEMEMKFSNYYRNENNELYCLMSKNASYLKMNWYKINFNFQKKTAHFNLLSKINLYGNDEVGYMQNAMIFTAPNIFLFKSGFYVSTIIIRPLTLSEAAYFSLLQTFEPNNQQRISINCNPSKKSKLKRPYQIWMSMNCLYNYFKIGKNISIKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8K4</accession>
    <name>A0A914Z8K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8K4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8655.t1">
        <property type="protein sequence ID" value="PSU_v2.g8655.t1"/>
        <property type="gene ID" value="PSU_v2.g8655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8655.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32497" checksum="E5219434B8F2B319" modified="2023-02-22" version="1">MRCDDTTDHSLLITRFTLVAAFGGAVALFGVIANAALAKLFVSKSNYRHSPFFFLGFVAIFDTLLDITYILLLEIVIITRSECDVYFQRYAVGQLNNRSWLSGFLNMLTICIPFVTLIFLNGGIVWMLRQQNIQQLRSLITELTMGHDVMKIRRRNLRCATNTLIVIITAYLISNLLNLLLSLVEYLKPGLLQHQYPYAYRLSADLASLFTVIGNALRCPAHPQEKHSIRRQSEKLENPAWISVLLINHDDDKSTNEATSCIRKNNGLQAVFERDNIRRLSNIGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z952</accession>
    <name>A0A914Z952_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z952"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9201.t1">
        <property type="protein sequence ID" value="PSU_v2.g9201.t1"/>
        <property type="gene ID" value="PSU_v2.g9201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9201.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16962" checksum="75EB47E535E36FC2" modified="2023-02-22" version="1">MNFTTTTAAEFQDYQFLPLLMSECKIQCVHDTECANIEGFDDLHVCVHPTLLNKPLSTIVGVTENVLMKNSAPSSELPSGASLKFLIFIIIVLGLMVLVMFAHGMWKRYSRRKERGRQILKNESTGLRLNLINSQPVTTTSVETVETTEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z955</accession>
    <name>A0A914Z955_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guided entry of tail-anchored proteins factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tail-anchored protein insertion receptor WRB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophan-rich basic protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z955"/>
    <dbReference type="WBParaSite" id="PSU_v2.g886.t1">
        <property type="protein sequence ID" value="PSU_v2.g886.t1"/>
        <property type="gene ID" value="PSU_v2.g886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g886.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22224" checksum="ABF556F9E0DB2BDF" modified="2023-02-22" version="1">MADTFSSALPGNAGFLTPEIINGIYTFGILFLKLTATVLGVAAFGISARMIDFDVTKVISVFYRKTESEKKMEAMENEIQILKKELHEISEMDEFAKYHRKRRILIKLQDEYEILSQQEGQTKMYKYLKLNILSRVIIAVFAFLFSYLSRDIIVAKIDERIFWPCNFLLTLPWIFTSSDQGGKILTFLVYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAA0</accession>
    <name>A0A914ZAA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8848.t1">
        <property type="protein sequence ID" value="PSU_v2.g8848.t1"/>
        <property type="gene ID" value="PSU_v2.g8848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8848.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11191" checksum="550DCF10F1F77295" modified="2023-02-22" version="1">MFCSFPHSGSARVFNFCHFKPAKSILRKPSVTESNACHPSTSESASTYRSLSDSDAEMVPEYTVDTRFLLKNEREEKIADFTGIYAPSTQMSDEQRNVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAX3</accession>
    <name>A0A914ZAX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8911.t1">
        <property type="protein sequence ID" value="PSU_v2.g8911.t1"/>
        <property type="gene ID" value="PSU_v2.g8911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8911.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20150" checksum="36B1C801C53F1E93" modified="2023-02-22" version="1">METEDVFNVAEEIKNRLTEYIPFVDFYKMSQAFLVDFVAAKGFTSVEQALHAHYICVEIKNGDNTLTGTFKDDFKLYDQVRGYEYGRTKITHHSEVKQRFFKLKFKIPSIPSTVTKMKGVEWYLCLEQDGVVTVKNHNFLANTDYLICELYAKDDFRLLGKSTMISASRHKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBS7</accession>
    <name>A0A914ZBS7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBS7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9379.t1">
        <property type="protein sequence ID" value="PSU_v2.g9379.t1"/>
        <property type="gene ID" value="PSU_v2.g9379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02790">
        <property type="entry name" value="MopB_CT_Formate-Dh_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.90:FF:000001">
        <property type="entry name" value="Formate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000011">
        <property type="entry name" value="Formate dehydrogenase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.90">
        <property type="entry name" value="ADC-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.228.10">
        <property type="entry name" value="Dimethylsulfoxide Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.460">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041925">
        <property type="entry name" value="CT_Formate-Dh_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF14">
        <property type="entry name" value="FORMATE DEHYDROGENASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9379.t1"/>
        </source>
    </evidence>
    <sequence length="544" mass="60898" checksum="B57EA43025235E85" modified="2023-02-22" version="1">MKKVVTVCPYCASGCKINLVVDNGKIVRAEAAQGKTNQGTLCLKGYYGWDFINDTQILTPRLKTPMIRRQRGGKLEPVSWDEALNYVAERLSAIKEKYGPDAIQTTGSSRANHVINAKRNGAKIIVCDPRKIETARIADMHIALKNGSNIALLNAMGHVIIEENLYDKAFVASRTEGFEEYRKIVEGYTPESVEDITGVSASEIRQAARMYAQAKSAAILWGMGVTQFYQGVETVRSLTSLAMLTGNLGKPHAGVNPDIFMTKTASAADVILPSTSWGEHEGVFTAADRGFQRFFKAVEPKWDLKTDWQIISEIATRMGYPMHYNNTQEIWDELRHLCPDFYGATYEKMGELGFIQWPCRDTSDADQGTSYLFKEKFDTLNGLAQFFTCDWVAPIDKLTDEYPMVLSTVREVGHYSCRSMTGNCAALAALADEPGYAQINTEDAKRLGIEDEALVWVHSRKGKIITRAQVSDRPNKGAIYMTYQWWIGACNELVTENLSPITKTPEYKYCAVRVEPIADQRAAEQYVIDEYNKLKTRLREAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCK5</accession>
    <name>A0A914ZCK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear pore complex protein Nup214</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZCK5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7987.t1">
        <property type="protein sequence ID" value="PSU_v2.g7987.t1"/>
        <property type="gene ID" value="PSU_v2.g7987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844:SF1">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="6">
        <location>
            <begin position="36"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="926"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1185"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="666"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="937"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="974"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1208"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7987.t1"/>
        </source>
    </evidence>
    <sequence length="1248" mass="135877" checksum="38FB9B6A4266EBC0" modified="2023-02-22" version="1">METIQDLQLRQIRKFRAFPPQNLASTEFGRKLVGISSRYGFAVIIGPDNRLISVKTTDLQALQADDFKELNTFPKRDMDFFNLQAEIFSVEFNSDGRVLAVAANTQNGAFVYIFDGFTFYPSYPQQPFPLQSVRLTSNSSAKLTAFEWNPCIPEMFATSTTDGLSTIQYTLNNPKSYSILGNQVLKSAVTCISWSPKGKQLTVGDADGKVHQLKPELAPVRTIDAPPSLPGLGNPPYRCVGICWLSTTEWAVVHSSATNYLNLSLLTGKKNQAPTWDSWSGVLPPLSDPSVPRSVNFLPLFDWQFVLATSTCLTNAVTFGSNGIVWKPWELPEPFVINTPLSTSHKDTFIVGSGFDFTSTKPVVIERDGTEAPPQPIIYTLTSDGILLLYHVTSLNPARPSLIKPIEPCDLNATKNGDQPMGFQPRPTTTTPSQPATVSTPIRQAPTSLFGTPPAQAPTSLFGTPSTPNIFSSLARTESPSTPTTTMQNTVTSNTAAAAEEEEKQKKEAELKAQAEEQERQKRFAAEEEQKRKAAAEAEAQKQQAEEEAKRKQQTAELEANFKANLDGLVSKLNEYSKSVEALRAFKMKLMQNTKLNVEFDAHIEPMLKSIGYVSIIGNDIDESLTRLRQVSNSIQRSAKESQQFLLKDSKELPTPEWVLELSDDLDELEQREFIVVEKLQQAEEKMEKISKLLKEGKAKFVPRNQLTPEQQQKLEKDSKTMLIFVRKLWERIKILRHQLRDINFDEKIMQAKQAIRSAGGEQNVSILNESDANFDTSDNNASMLASELIASISLVDKTNGGTSEPVKNNVQNLLKHLDQASSRPPKLVNVVPIDQFVSTQKLKETAPNSTILKPKVAEAHKNLIEHLMKVQSPRAITQNIPAAPPRQPLTLFDNRAAAPQPTTVSTPQQQKSLFGTGNISVVTPTSAAPTSTSSPFGSLSTFGQQPKTSTPKPLFSSNTAFTPQQSASPLFGTSLTSSPLATTTTTPKIDAEEQKRKEAEEEQKKKDAAEVEAKKKAQEEAEKIKKEADEKAKKEAEEQERLKKLEEEKQKAEAEARAKAEEEEKKKKAAELEAQKQAAAEEEAKKKQESTAPPSNAAPLTFSFKPAAAALPSVVSAVAPTTAVNFSFKPQATATTTPVKSESNADIGMEDDGLDSALAGTNICSPTNTGNAFGSGTSGGGFSSFGGNAFGQQPATTPVLNNPFGGFSSTPTTAPANGSPFGGTSAFGATVKNPFGGGTTNNTGFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZI12</accession>
    <name>A0A914ZI12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZI12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9942.t1">
        <property type="protein sequence ID" value="PSU_v2.g9942.t1"/>
        <property type="gene ID" value="PSU_v2.g9942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9942.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23194" checksum="538F29AE58B28542" modified="2023-02-22" version="1">MFNLGEESSLGFLGIPAYTSSIYDQQNFVQLVSEGLSKTPLYLSTVQEELDLYNKFHRSDRILTRRLKLHLVKFVTSKKEAQICHLLKNLQNGLGVSGKLEDSLTRAAETNGPEDLIKPFELFEECLHLIGEKKSGEIKACLVDFKKVEKENNEKQKVIYGELIEIICDYLVPEIQKNIRFEMLLIIWINRGLKIINWCMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQ45</accession>
    <name>A0A914XQ45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XQ45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10140.t1">
        <property type="protein sequence ID" value="PSU_v2.g10140.t1"/>
        <property type="gene ID" value="PSU_v2.g10140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="56"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10140.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42619" checksum="6BB68DA4BC36835A" modified="2023-02-22" version="1">MAVELNFSQNVNKPYDSIWPNVTCENDSPWPSCLSLGTAFVTIAFMLIVMLVIVLGNLLVVLTVNNDHKLRSQRQNWLIVSLAIADLLVGLLVMPLTMTYEIIGVWVLGDILCELWLALDVLFVTASILHICIISLDRYWSVTQPLTYPSKRTPQRITIMIGVAWSVSLLICMPPILGWRQPKASGECSTKTCEDNINVSKIAISINGTSSSGDEIYLPQKFDNNNTIKVSPEKKSKVKQTFNRKLFEFNSLYTKRSKWMSSLEEVSESSNGKKPTDKRRKLLKAKERQATMLLGLILTAFIASWLPFFVLYVLGAFSYEAPTVVFKFFFWLGYCNSGINPVIYTVFNREFKRALCRQLRRQQRAILSFWEHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRV0</accession>
    <name>A0A914XRV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XRV0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10713.t1">
        <property type="protein sequence ID" value="PSU_v2.g10713.t1"/>
        <property type="gene ID" value="PSU_v2.g10713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002938">
        <property type="term" value="P:tRNA guanine ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18092">
        <property type="entry name" value="SpoU-like_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000009">
        <property type="entry name" value="tRNA (guanosine(18)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02060">
        <property type="entry name" value="tRNA_methyltr_TrmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022724">
        <property type="entry name" value="rRNA_MeTrfase_SpoU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033671">
        <property type="entry name" value="TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008295">
        <property type="entry name" value="PRK11081.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43453">
        <property type="entry name" value="RRNA METHYLASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43453:SF1">
        <property type="entry name" value="TRNA_RRNA METHYLTRANSFERASE SPOU TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12105">
        <property type="entry name" value="SpoU_methylas_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RNA methyltransferase SpoU/TrmH type C-terminal" evidence="8">
        <location>
            <begin position="152"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10713.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24008" checksum="AFE1B3D6BACDD7A2" modified="2023-02-22" version="1">MLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMASAAAGSNSWVQVKTHRTIGDAVAHLKGQGMQILATHLSDNAVDFREIDYTRPTCILMGQEKTGITQEALALADQDIIIPMIGMVQSLNVSVASALILYEAQRQRQNAGMYLRENSMLPEAEQQRLLFEGGYPVLAKVAKRKGLPYPHVNQQGEIEADADWWATMQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS53</accession>
    <name>A0A914XS53_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partner of Y14 and mago</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XS53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10104.t1">
        <property type="protein sequence ID" value="PSU_v2.g10104.t1"/>
        <property type="gene ID" value="PSU_v2.g10104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10104.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19259" checksum="556DD11AA8C22E10" modified="2023-02-22" version="1">MSKPETGGDNRIKTKTGETFIAATQRPDGTWRKPRRVKEGYVPPEEQPKYKCPAAVEVEKETTVSSGPKYPVGWSPLELKQMAENAQRKKTDQVRLPVAASMASNAPITPQDHINKKLLNLRKKLNDIEKLQTKAESGETKLELNQQQKIERKPEIEAEIDKLTKELEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTD8</accession>
    <name>A0A914XTD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10531.t1">
        <property type="protein sequence ID" value="PSU_v2.g10531.t1"/>
        <property type="gene ID" value="PSU_v2.g10531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10531.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10461" checksum="978C0141A0B91690" modified="2023-02-22" version="1">MEEVKLLEELQDEETIIQMEAYELKKNGDDEKQLFVVMEKGENDFQTFLRSIDRSSNLIRYYWESMLNCVKVVHSKSEEISIFSYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVM7</accession>
    <name>A0A914XVM7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIF1/LRR1 pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11028.t1">
        <property type="protein sequence ID" value="PSU_v2.g11028.t1"/>
        <property type="gene ID" value="PSU_v2.g11028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11028.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22099" checksum="D0AAD959B7B15613" modified="2023-02-22" version="1">MKLTCKYSSTVSNGKPSKPVQVQIGFCRRDSTLQMHIVSKMKKEKLCVTSTNIKKIHDKFKAKGKATIEFKNPDYAIMIADASATELDKALRVIAMVARGGKAESIDAELSSILPTMKPKDLKIKESITDIDDYPKKDGFSASLIELSINTYKMTGVDIRWFALKHLTKLDLSHNKLGKMDEFEWKKFNKISSLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWL7</accession>
    <name>A0A914XWL7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19369"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:11600"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16367"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.85"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914XWL7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11618.t1">
        <property type="protein sequence ID" value="PSU_v2.g11618.t1"/>
        <property type="gene ID" value="PSU_v2.g11618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025785">
        <property type="entry name" value="SETD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51565">
        <property type="entry name" value="SAM_MT85_SETD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11618.t1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57590" checksum="60A8CB93D46AC9B5" modified="2023-02-22" version="1">MKDETIQEVSQLFQKVLTVVPSENPKELYADHVKIRQVLEKISAEQDKFVPNKDRASKLPAFLEWAKNNNIKFDNSEIKESDKGFSLIAKEDIPEKGNAVEVPRSAILTSDSSKINKGLRELFLNDQLVQSVENCSLVLLLAHEYLDPKSHWTPYLDILPGELLSPLTMTNEQLLSLKPSNAFILAMQFFRCIARHYVYFFLMTHARESARLLPKLSSDAIKKTLFTSKNFSFDLYVWCTAIVTSRVNRIPNLVQIGNQTTTSPSLIPIMDFANFEFIGDAAAAQSEVFYSIPHKKVQLLLHRNVKAGTEILIPIGNKSNRDCFLYSGFVPLEDSPVDIYELRLGFPQKTEQWKLTAAQRMGVLNSKEMAATFVIHLSTFYSHQLEFSAFWNFAKLFVAKTANDFNTEANIKQAREYLLKRFTLYLEGYKTLPKSEPKDASSLEKYIWRLKRSEQKNLEAMVAYFEKSVEEIIKSNGTTFPEIQENSTSAQETPTAPTATPTTSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWT1</accession>
    <name>A0A914XWT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWT1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10993.t1">
        <property type="protein sequence ID" value="PSU_v2.g10993.t1"/>
        <property type="gene ID" value="PSU_v2.g10993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10993.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18973" checksum="CBD3D293C650E2D6" modified="2023-02-22" version="1">MNFDGQNWNRNSPEQMREMVQLYFDQATIAKREAALNAERNLNLQSRLSTSEITNKRLLDILEGLEPKLIELLQKAAENEMVRIDATQEFKDAHDRLEYETKTLSKELSKVQKDANDFAANCRKLQHENIEKNSEITKMKNREDISEKELESLKLKYSNIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWY5</accession>
    <name>A0A914XWY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWY5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12460.t1">
        <property type="protein sequence ID" value="PSU_v2.g12460.t1"/>
        <property type="gene ID" value="PSU_v2.g12460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12460.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29089" checksum="2AFB3E3D409EC993" modified="2023-02-22" version="1">MLNNLCRGIISSPSTKVVATPTTTGVSTPSHSAIVNNDSSPSSNELTFVVMGGEKVGKSALVSQFLWDKFIEEYHPTVEEFNWIEYDIGGHELMLQVIDTAGSHDFLAMRSLYARTGDAFFVVFAVDDPASFLEAKKIIQEIREENHRNASILLIANKTDKISDLEDFDQSEFEEFASKENIGYVTVSAKESLKVNKLFGDFLNKLKIHRIPTANEYQLRKRRQSMPSRRHGSDGIGIDVADLEKIAKRHSRRENCCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXT1</accession>
    <name>A0A914XXT1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.258</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XXT1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10542.t1">
        <property type="protein sequence ID" value="PSU_v2.g10542.t1"/>
        <property type="gene ID" value="PSU_v2.g10542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10542.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17943" checksum="8CFF9EF55D6E973C" modified="2023-02-22" version="1">MHRRRRGEPQTLRPMRHASPSKQKRFFVFWEKLFSNFEGFFKQLCNPASQTLAIYSILFSLAFDTLLSYLIVRLRPYTEIDWSTYMQQVECYVKGERNYSNIYGDTGPIVYPAGHLHVYHYLYQITDAGKNIIKGQYLFMLLYLFNQATNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y014</accession>
    <name>A0A914Y014_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 21</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71739"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71755"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:72701"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71747"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71751"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71759"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71743"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y014"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12799.t1">
        <property type="protein sequence ID" value="PSU_v2.g12799.t1"/>
        <property type="gene ID" value="PSU_v2.g12799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12799.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17485" checksum="2509873705142DD0" modified="2023-02-22" version="1">MTEGAIVSPFETVKVKMQSDRSGKGDKKPKSLASVAREIIKKDGYGKQGLLRGLDATLARDGLWNLLYFGIYHNLKPLIPIKEGKSQPPVTLRFLLGFTASALASIADIPFDVVKSRIQGPQPSTGRIYHGVFQTMSLVVKNEGILALYAGMVPKRMYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0D0</accession>
    <name>A0A914Y0D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0D0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12669.t1">
        <property type="protein sequence ID" value="PSU_v2.g12669.t1"/>
        <property type="gene ID" value="PSU_v2.g12669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF37">
        <property type="entry name" value="OS05G0311600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="3">
        <location>
            <begin position="232"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="672"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12669.t1"/>
        </source>
    </evidence>
    <sequence length="759" mass="84103" checksum="650281845204DC3B" modified="2023-02-22" version="1">MVKDIRSFFQPPRKKAKTSEASETLGFTSEHSSDLTLNTGHDTTSEFTLTTGHEHSSSAAASASSDGSSSSNASGSASDVSSDPTTSAASSSSNAFDSSVSDSAAASDVSSGASDSTSSAASSSSTGSSSIMSLCNIDPAHIVNQKLTRKECFHVLNNVFRPPPNFDFPSKIQGKCAKIHVNNDYHRKAVATVNSFSTNFSSVIELMDDNAAKERTKANKQLDEVINGIKFCARHRLPLRGDKDSGPFKLETDGTTEEGILRGLLKFRGEKYEGIQILAKAPLNAQYISPSIQNELLSIMAQLIQKKIVKEINESIGFTLIADETSSHSKEFLSIGIRYVTKNLEIKEEFLGFWRVEETTGEALANHLLKTLPELGVDMSKLLGQGYDGAANMCGIHKGVSTKIQEKFPAASYFHCSNHGLNLGLDIDKNLAIKKVMTQAGKKTAAKEKAEADGSKYEKLFKKKRIPLFSETRWVERHVSLLAFQELYPAVIETLQELVDTRNDADADSFLQYFLSAEAIFALFVAVKVTEPLLVLSKALQKPDNDLIAATTHIMAVKTMLQSWIENEVEFNILFVKMKEVCEEYELEVGLTRRGRRPTLPFEEYLRKHFFKDYISAVVKGLEFRFGNKQQAAFSLQLLIPSKVNELSFDMLEEAVNHLLQKRPSSLKDTLLLFNSTLSTMYPNIKTLLTILATLPVTTVIVERSFSTLRHIFGDFRACMNVERVSDLALLSWHDKMTHQLETKEVIEVFNQKGRRANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y216</accession>
    <name>A0A914Y216_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y216"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12822.t1">
        <property type="protein sequence ID" value="PSU_v2.g12822.t1"/>
        <property type="gene ID" value="PSU_v2.g12822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12822.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21559" checksum="22C76428ADE2AC86" modified="2023-02-22" version="1">MAEKLIIPTAKGSLDALFYKVQASTSAVIFVGGAGGGWNSPNQARMYPSMCVKLNQIGISGLHLKYRYGGDLEESTYDILETIKFLKNNGFQKAGIIGWSFGGAIVCQGAGKAEPGFVKAVATLATQSAGIEPIQGVKDCASLFIHGNADSCLPMRCSEYTFKLAPDPKKLMIVSDHHGFFSTAKECENAMIEWFSKYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2T3</accession>
    <name>A0A914Y2T3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2T3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12086.t1">
        <property type="protein sequence ID" value="PSU_v2.g12086.t1"/>
        <property type="gene ID" value="PSU_v2.g12086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12086.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29698" checksum="1793209DBC122DA9" modified="2023-02-22" version="1">MYDAEDTNFDTTNKADLDIKVPKKLTREELIQSARGFLIAGADTTATLLNYCLYELAKHPECEEAILQEINDFITSEVGGEGVLGTSSVYPPPLTFSIHKSNRSDDINYNKVKDLTYLDRFVKEVARFHPLAFTVTARRAIHSTTLKASDGKLIQIDKGVAILGNAFAIQMDENIWGSDAKEFNPDRFLPENFENRHSMAWLPFGIGPRICPGKNLALHEAKSTLIFLLRKFKFEFCDETNTDIITDTITNFKTLKMKIVPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3F2</accession>
    <name>A0A914Y3F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3F2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1398.t1">
        <property type="protein sequence ID" value="PSU_v2.g1398.t1"/>
        <property type="gene ID" value="PSU_v2.g1398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1398.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48865" checksum="2A0BFF002139FB83" modified="2023-02-22" version="1">MDDKLSFLSGESDNQSRSSTPKSQSSDSKNQEQGSLNGDHKNHTNEIDDEKVNLNSDVAEKKKSEVYTEGIVYVKDEIVQPKRKLSVIPQNEDDLTVDGLIRHKSVSPPKFSPTNYIYIRGLRRPFTFVQFYAVLSKFGTFNKDDDTWIDGLRSQSIIKYSTVEEAKKARDGLHHVVWPEYNGSELLVDFTDEEEFIEKKGIIKKVIKQENNVFAKEKSPSPMQDDLPSPKEAAVKRERLDTAEDTDEGPSRKKKKDAKSLEELFKRTTAQPSIYYLPLSDEEAARKQVQKAIEKRGIKEPSVEPLPLPLPTAGVAAASSSKRREKSVSPLPARRRSRSPLRRNDKVSPRRRSPPRRSSPPRRSRDGPPPRRPRSPRRSKSPSSKRRSPSPRRSPPPSRKPTATTLATSPSFKKTATSPPQRRRSPSPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3H5</accession>
    <name>A0A914Y3H5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3H5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12312.t1">
        <property type="protein sequence ID" value="PSU_v2.g12312.t1"/>
        <property type="gene ID" value="PSU_v2.g12312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12312.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16404" checksum="99C0CD8C3EF7AD57" modified="2023-02-22" version="1">MILFFELIEWLEGFNKKSRPFFSKLKDNIRLVATKVTASTTTEDPYDNNENDAFTTESTDVSLRDQTHLLDLLKDPSPSSSKQRISSSDESSPYITYSSANQSQRHTQPTTPTTTRGLSRAGLFSASNAAVASRSQSAFKSSSRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5M4</accession>
    <name>A0A914Y5M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 23 member 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5M4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14066.t1">
        <property type="protein sequence ID" value="PSU_v2.g14066.t1"/>
        <property type="gene ID" value="PSU_v2.g14066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14066.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="38948" checksum="5CDBD145BF2EAD65" modified="2023-02-22" version="1">MPSTVDRIEKHWVAIVQAATLFATTLYLAEVRVPLPGLRNGKFYWYKVHIFGQYPYLIAITVSWLFCVFLTVTNLVPPNSEARTDKQRNIDAIDFSLVFLVSAMASVIESVGDYHAIARISQERAPPSHAINRGIFSEGFGSFLSGLIGPGVGLTTHTENIGVIGITRVASRTTLVIAGLWLIGLGLFTKVGAILSTIPDPLVGGVLASSMAMVSGVAIANVQSVDLKNSRNMGIIGFALVCGLVIPGYFARHPIQTGIEVLDQSLDVLLKLQMFVGAFVACVLDNTVPGATREERGLRERGLAPDLGPNGRDIYLYPRYVMNIIERFPLLQKFPMVPKVKVTNSQNFQDINEFNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6S8</accession>
    <name>A0A914Y6S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6S8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15151.t1">
        <property type="protein sequence ID" value="PSU_v2.g15151.t1"/>
        <property type="gene ID" value="PSU_v2.g15151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15151.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18001" checksum="8765D5FEA829B796" modified="2023-02-22" version="1">MTSGPTVAATTGSSTAPHHQHHHHHHQQQTSQHRRNLTTTSGAGAAAAAGAPTGFIPIQPRSDATPKQPRKRYRPPTPAANSIGTLQDKPLQLETVALLSIFPTNSIEATAAQFLGPQKRPPKKFSKDFKRCKFAFFMGGKTVVDILVCVLPYLRISSKQNSKKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y755</accession>
    <name>A0A914Y755_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y755"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15104.t1">
        <property type="protein sequence ID" value="PSU_v2.g15104.t1"/>
        <property type="gene ID" value="PSU_v2.g15104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF269">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN ASIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15104.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31095" checksum="1E5D1A104D384693" modified="2023-02-22" version="1">MSSSLKLVLNDFADWSSAAGIPQIAYAFNRIVRALWFIIWIGLFAVTIYQFYLIVSRFLSYPMKIVTNLQYGAQDFPVVTFCNNNPLIYSKVKNITAYKKINDLMEQYQSMVKNNYGSITGGDPYGLNTPKTRYEKTEWANEALVLLMNQLTEAQKNNAMYKFGEVIKVCSFNGIECTEANFTSYYDATFGRCFQFNSKDSNSNYRTLRAGSGFGLQVLMLINQFDPNGDNLFLPTTSTAGAKIGINLKGEDPAMESYGISVPVGQETLIGLEFVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7G1</accession>
    <name>A0A914Y7G1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7G1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16143.t1">
        <property type="protein sequence ID" value="PSU_v2.g16143.t1"/>
        <property type="gene ID" value="PSU_v2.g16143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16143.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13710" checksum="BC031739870CFC57" modified="2023-02-22" version="1">MGGKLRPVDFKKASLKPIEKDIYHEHATVQRRSQFEVDEWMSAQQASVEGRDLPRPVFEFNECGFPGEIESLLYGNFKKPTVIQSISWPVAMSGRDIISIARTGSGKTLGVIYSSWYYAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7V6</accession>
    <name>A0A914Y7V6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynein heavy chain</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7V6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13685.t1">
        <property type="protein sequence ID" value="PSU_v2.g13685.t1"/>
        <property type="gene ID" value="PSU_v2.g13685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000013">
        <property type="entry name" value="Dynein heavy chain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="3">
        <location>
            <begin position="283"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13685.t1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41404" checksum="45476B944006E318" modified="2023-02-22" version="1">MRKVAGSPRILDVVHMQGAQRLLERLAEMLAKIQKALGDYLERERSSFPRFYFVGDEDLLEIMGNSKDIFRIMKHLKKMFAGIMAIEYNEETKLITGMVSREGEHVELSSPIDLNKTPRVNDWLQKLESEMRNTLAKLLAQSLEHFAKFDFNKMDMNSYMEWLDAYPAQIIGITADIWWSESSEKRLAQSQRVEDVLASVEKTLELLSDSVLRDQPSVRRKKLEMLITEFVHKRDITRELVTSNVVNTTDFQWLQVMRFYFVAKELDPVKCCVVKMANAVFYYGFEYLGIQEKLVQTPLTDRCYLTMTQALHARLGGSPFGPAGTGKTESVKALGQQLGRFVLVFNCDETFDFQVCLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8M9</accession>
    <name>A0A914Y8M9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Calcium-dependent secretion activator</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8M9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1394.t1">
        <property type="protein sequence ID" value="PSU_v2.g1394.t1"/>
        <property type="gene ID" value="PSU_v2.g1394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01234">
        <property type="entry name" value="PH_CADPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000343">
        <property type="entry name" value="Calcium-dependent secretion activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
        <property type="entry name" value="C2_CAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="99"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="13">
        <location>
            <begin position="491"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="741"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1394.t1"/>
        </source>
    </evidence>
    <sequence length="921" mass="104835" checksum="5491CAB666383D65" modified="2023-02-22" version="1">MEVDGCSKLQTDHAEASKPSWDTQGDFTTKHPLPIVKVKLYAEVKNMISFEDKELGKVVIRPHPNCSRTPEWYKMTVPKNSQDQNLKIRIAIRVEKPPNLKYCGYCYALGKIAWKKWKRRFFCLVQVSQYAFAMCSYREKKADPTEFIQLDGFTIDYMPEPDNDLYNQGGKHFFTAIKEGDELKFATDDENERHLWIQALYRATGQAYKPVPPKQSTTVSKAQGFADKASKHGLDELIQADPVMINHDHHFSTLQKVALDYRLNEPICSLGWFSPGQVFVLDEYCARYMVRGCFRHVSLLNDLLNKADEGHLIDPTLIHYSFAFCASHVHGNRPDGVGTVTLEEKEKFQEVKERLRVLLEKQITNFRYCFPFGRPENALKGTLSLLERVLMKDVVSPVPPEEVRAVIRKCLEDAALVNYTRICNEAKIEQRMGIDVSPQQRIEDMIRVTELCIDLLKENEEHHGEQLRGAFAWFSDLLADHSEIFWSLYSVDLDAALEVQPPDSWDSFPLFQLLNDFLCSEPTLKNGIFHTKLVKQFSPLVIRYVDLMEHSISQSIEKGFQKEKWEVRKDGCATSEDIYWKLDALQGFVHDLNWPEEEFAKYLQVRMKSLAFDMISKCANCTYQTFDIFMQKFRKSTDYILPCEVCVMINVIFSSKARATKLTIDAGDSKIDETLDTMLSDMDTCLQEKLLSILEYVLGRLSRYDEGNPIGALLSMAPKPNSIFNKMKNLVGDQGIVQNLTGSSSSTAGSPSSANAKTAANQQQNSGHMGHSYVNFMRGSSETLRQFVTDEVWVNNLFEQWFSGQMNMINEWLTERLQQSLSPYQLTCLSFIVKKVHSDFELQGIDEELLNSKSYESINRRLKLEETNCALNENNTSTNSSSSFAGANSFSLGNLGNAQAAVSNVSSVMEGAGAKVFALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA04</accession>
    <name>A0A914YA04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA04"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16267.t1">
        <property type="protein sequence ID" value="PSU_v2.g16267.t1"/>
        <property type="gene ID" value="PSU_v2.g16267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16267.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16121" checksum="176A2FD224713639" modified="2023-02-22" version="1">MLSLFHRNEMCKLSVSNDKHNWIIVDNLEDSNPVTVLQLCHDKMIKEYGDVKVMYLCGADAIDSFIEAHSKGKSKFWTFEELKTILDKYGMIIEVNSNRPGNATDPIKILEALNLPTKNVFTVSSTDDISRNCGRKCYKLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA20</accession>
    <name>A0A914YA20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16280.t1">
        <property type="protein sequence ID" value="PSU_v2.g16280.t1"/>
        <property type="gene ID" value="PSU_v2.g16280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16280.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23004" checksum="9E4E85D77DE9CE88" modified="2023-02-22" version="1">MLRVDEVVLVHFSPRIDGDLFKEKTATQLVCKSDVSKPILMGLVDQEAILFAVNPFGKLATSGKYIWIHPDDIPNVGKSRFSDYVTQKLADKKIFGSSAKDYADAVINFYESNVKVSSVNNRYLTMLTQLISDVNFNIPALREAKLRAAAGQKVYFYLYTYINPKYKSQYFDAVAHADELPCFFDAPIGKANVEMEGEEGEFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA93</accession>
    <name>A0A914YA93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA93"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16202.t1">
        <property type="protein sequence ID" value="PSU_v2.g16202.t1"/>
        <property type="gene ID" value="PSU_v2.g16202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16202.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12626" checksum="93094D0A32BFC32A" modified="2023-02-22" version="1">MATSLSQKKKEPVFEDDSEGETPVKPKDQKNEKQRARKRKTSDNEDDPAVDLPKRPKDNNEKNVMQQTSRKQSNNEDHSESETVIKPKTDKTQKAVKQRYMNILNISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBE7</accession>
    <name>A0A914YBE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBE7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1609.t1">
        <property type="protein sequence ID" value="PSU_v2.g1609.t1"/>
        <property type="gene ID" value="PSU_v2.g1609"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037334058" evidence="2">
        <location>
            <begin position="22"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="653"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1609.t1"/>
        </source>
    </evidence>
    <sequence length="814" mass="95379" checksum="24EA0A0B92BC6735" modified="2023-02-22" version="1">MIFRLCLNLAFISTFVWLLKAQTLSFPDEKDKISIKSTRLKNVKCLELKFAWTQQLRYVQKELFKVVNQSIVEFDMKDFFNKNNTYCVGSADNECSSNEENKNDETQINHQPQIGSEILAKDSGPDKCVKNHRNFFYRQIFVCERFPIKKESDVEPNEAQLDFLKDYMQYTVLRYCNNLNLDKEKRYLQNFIDFLFILRNTPRFAVCDTVEIEKEQKEDCFENQSHDNIAHMCHSADPKDMSESFFTYFYDKIDANNTADKVLKDFDELSYNMITIEAEDIRHIIDKLANVVKQVPEIKTQMKVLEAINIPLSRELMISNLLLNSYGKALRNAKKRLNAYCKETSPKMTTNLKQFEPECMPESLWQRTPYTLGITDFDDLIMYENIRIVLRILLLVISLFVNAYTFFVVKASALDMPYISSKLIQLLLIANFLFIVTDFFVILDSFFPFAPQDEYMDFIAMTNFDGDLWENVTYYVNMETVRNTLYYRYDGKEGIETEASFASTWANINIILQTFLLNISRTYSAIILLSVVCYVLYELRNSFGGRLSKKTTLCFKLTLAFCFVVVTAGYVIAGILQYFVIDYINQAMKSENRTVICEQVTIKSYQIRIHTYMMTAFYILSSLATFIVFAYHKLHEIVAPVDTKELKIEMRSTLISLGVATAVYIFSNFFTTYTELALTLGSSEVDNITIATLTTWYQWLYLASFADPIIHPFILIYRIKAMRLIHQHWKKQITSFSLSDYFVSFVVYVHQYPQRRRMKKDYKRFKNSSKASFPAITNDTMRHRHTRIHSFQLDHDVNSMLDILAKQKNPSYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBM9</accession>
    <name>A0A914YBM9_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16168.t1">
        <property type="protein sequence ID" value="PSU_v2.g16168.t1"/>
        <property type="gene ID" value="PSU_v2.g16168"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16168.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10327" checksum="F1A2923E3769E7FC" modified="2023-02-22" version="1">MGSECLKGFDGLDDEAKLAACYTKCDTFLQNELHAQIDALRAENVAMRGDTASIRDTLVWAAILFFVGLSCYILGRCQRYCPGKVKQIFDKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC22</accession>
    <name>A0A914YC22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1698.t1">
        <property type="protein sequence ID" value="PSU_v2.g1698.t1"/>
        <property type="gene ID" value="PSU_v2.g1698"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF42">
        <property type="entry name" value="QUAKING RELATED 54B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="3">
        <location>
            <begin position="231"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1698.t1"/>
        </source>
    </evidence>
    <sequence length="459" mass="50719" checksum="96A7CBB3360120EF" modified="2023-02-22" version="1">MQRKRPLEPLMTPAAAPGGGVNVNGTRIPKNNYDGSPAYTDQQQEPASKRPVTHGDNYSYYGHEYAANADSWVPGYEREMHPSQFSAYSSSQMPMNPSAEYEYRTAYNQSAPSASITKNQPKRKLTTELPWPALPERAPNSKFGLGLDRYGHELPGPLMDELQDTVKEMQNEIAFLKRHPEVATRIPNAVRILEKGVMFKLDKCVDPEWLEVDINKPINIVKRIIIPTARHPTFNFVGKIIGNRGTTLHNLGKAFKCHINLCGEGSSRDRKKETQLYASNDEKYMHYGLPMYIQISTIARPHVAHMRIAGFLNVLHKLLIPSHDVHIAGITDGNTWFESGETYVYEPMIFDEAADEEKESELRSGAAGSSYRKPPRGSRGGAGFSSRGRGGIIPNPATTVEEDYVVCYDPDQFSSSKKAGSSSIAPDGISSASPRGGATARGSTRGRGRGRGAVPIRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC80</accession>
    <name>A0A914YC80_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16894.t1">
        <property type="protein sequence ID" value="PSU_v2.g16894.t1"/>
        <property type="gene ID" value="PSU_v2.g16894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF174">
        <property type="entry name" value="GALAPTIN LEC-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16894.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15388" checksum="1EA12201F043D410" modified="2023-02-22" version="1">MSFRFMHDQHQICMNASSHGTWGEEVRHHNSLHDGDHFHLHVHVHSGHYEVEINGDKIGTFHHRFPVESIQALGIHGGVHIDSIEFGGFSFDKPWSHEHQGFDYGHQGFIGYGTSSYQPPQFDDPQHPHQRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDW2</accession>
    <name>A0A914YDW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nudix hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17489.t1">
        <property type="protein sequence ID" value="PSU_v2.g17489.t1"/>
        <property type="gene ID" value="PSU_v2.g17489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17489.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13941" checksum="DB2B6EB398571E40" modified="2023-02-22" version="1">MPDSLVFPGGIVEPAIDAAFPESKTNYEEKENDAGICLNGFKNDFPLRVGAARELFEEAGVLLVFDSNIRECKALTPEHDKSLNEWRKKVRDDPSKFSELFGSSLKLDVDALIPWSNWLTPASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEA0</accession>
    <name>A0A914YEA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15733.t1">
        <property type="protein sequence ID" value="PSU_v2.g15733.t1"/>
        <property type="gene ID" value="PSU_v2.g15733"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g15734.t1">
        <property type="protein sequence ID" value="PSU_v2.g15734.t1"/>
        <property type="gene ID" value="PSU_v2.g15734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035126">
        <property type="entry name" value="SCVP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17619">
        <property type="entry name" value="SCVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15733.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15734.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21780" checksum="B087EE724A193778" modified="2023-02-22" version="1">MPPVAPLPALGDLNLADLPNLLAAPNLLVPPSSLPPLPSLAPLGTTLPLLTTLAEKKLTEKEQQATGKTNEEFLQKSKAYAPAPTPETCAGNKKAIVIAVSLDPYNPDTIATNLAKQHRSLRMLEVFTGKPVSRFGAYSEESLNFEGFYAYKMNFESIENCEDAKDFTTKAVSYSRHIEKAIFQCHCENFAISKLRSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEE5</accession>
    <name>A0A914YEE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18636.t1">
        <property type="protein sequence ID" value="PSU_v2.g18636.t1"/>
        <property type="gene ID" value="PSU_v2.g18636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18636.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8846" checksum="A9FCD65C320EDF77" modified="2023-02-22" version="1">MGNEILYHYIHEADEIVVDQWLLIHDLIDVVVAVVAGVVVVVVHGVFAGVVDDVQLVAVEMIDELRNNLKNILFCLCFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEL6</accession>
    <name>A0A914YEL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDE Tnp4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15829.t1">
        <property type="protein sequence ID" value="PSU_v2.g15829.t1"/>
        <property type="gene ID" value="PSU_v2.g15829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15829.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="17018" checksum="883FCA406ECB619B" modified="2023-02-22" version="1">MINEHMIIAALLQLLRKDNGYTGVQDFLVSIPKKHSHEDARFYEQVKTARIFIENSFADWKNSFRVLRKGCYFPHMQDNCMIIQVCAILYNFKKFQRDTKKSSRLLTKFPRLQPIGPDIPTFSSQNAHLYNYLRFMRRRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFS3</accession>
    <name>A0A914YFS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18168.t1">
        <property type="protein sequence ID" value="PSU_v2.g18168.t1"/>
        <property type="gene ID" value="PSU_v2.g18168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18168.t1"/>
        </source>
    </evidence>
    <sequence length="567" mass="64361" checksum="9661DC2ED9DA7BC0" modified="2023-02-22" version="1">MLIITYNLSEASDRIITEDKVCDEECLISKSNFHIKDKNRKVKPRSNSGTGTCSFQGIDTGASEEPFQLFDINNQQYDIASLTRFGGICDCSSNVKEAKHAVIKKELDGRIILTDAYILCGETENNEKILEELIFDYIKNVPERTLGSKPDLEKNDEYCLDERGFITAQLPGEIPCFSFISAFSNETYSSTNQLLEGNVNYYSGPYSVNRINQSEYVKHPSHPGKNISMIGLFYELGFTCNISKLNRESDNRCYSFFNSYIYSIICCCNKKPGQCSFRGYQDKSLFCGKGSFVMDLTRIVEMAPHVLVPNGTHVKELKRFAANKTFCSSQYVFDNVSIRYEMPAPSQAGLKDCNVGPKSEGSLGYCILNNDVCPSSRQNPPKTKITCCCREPNLCNVDFVAIHAVDRFEFMIRNKVCEQPMLYSVLFARTNYTASDDHKQPLCYIHYDVNQPTAKYFLPNNNIDLLRDIDYEAYKKEGCNVIAATIRPDFFAKCPDEKYKGDDTILPRPLLVCTCKGAKIDEETTKDTKFCDEELRNNIENKYNEIKDKLMPKCLGMLLLSLIAFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFU9</accession>
    <name>A0A914YFU9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFU9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18326.t1">
        <property type="protein sequence ID" value="PSU_v2.g18326.t1"/>
        <property type="gene ID" value="PSU_v2.g18326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040426">
        <property type="entry name" value="C05B5.4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057569">
        <property type="entry name" value="C2_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626:SF4">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38626">
        <property type="entry name" value="SKN-1 DEPENDENT ZYGOTIC TRANSCRIPT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25330">
        <property type="entry name" value="C2_nem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036834427" description="C2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18326.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34850" checksum="D4BF9B9966A3CDE4" modified="2023-02-22" version="1">MGVKYLCFILLFIVGSGNAEFWLTATVDSLNFNTNCIESSRCEISEASFKLSHQLPSLKELKSTHFPVVILHEKLTLISHWEFGNSNEIETSLEIVKSLGSKPAMTWTCDETNEIILVEERIESKTDFAVIKVKGRCFNATITLQKYLSHNCPWCIEPSSVALTSESSSFHLLLASKMEDPFVFWLIVVAAVLVFTVFALLCFLFIHLCTKSKTIYSVSSTPTMINSKNHLFGGSPTDSNPSYVNTKTFLKENSTNLPYFVRPEYLYSEPKYDKVVEFQTPKNGRRKVDPETPDSLIRTPSPSIISNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFW2</accession>
    <name>A0A914YFW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18204.t1">
        <property type="protein sequence ID" value="PSU_v2.g18204.t1"/>
        <property type="gene ID" value="PSU_v2.g18204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18204.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14805" checksum="BAE3A94F4ADDC447" modified="2023-02-22" version="1">MLSKDSLRKNHPEKVLLAQSILSSIFLLGSTLTSWLASVNGILSTETKKTPEVDRALSLQLFFSAISQSFYASHHYLGLILLLIMSQSFRNSYLQFYGIKRVSDKVSKMVKSDSMSNVTVISASSLKPKPTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFZ0</accession>
    <name>A0A914YFZ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19215.t1">
        <property type="protein sequence ID" value="PSU_v2.g19215.t1"/>
        <property type="gene ID" value="PSU_v2.g19215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF20">
        <property type="entry name" value="BESTROPHIN HOMOLOG 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037823665" description="Bestrophin homolog" evidence="8">
        <location>
            <begin position="17"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19215.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24599" checksum="D55668C4A5461DF1" modified="2023-02-22" version="1">MIQFIVYMGWLKVAEALLNPLGEDDDDLECNYVIDKNLITGFTLVDQGGKRAPVIKKDQFWDNDHIAPLYSLEAAKRTVHPLVGSASKVNLVKNVQKVTMTPHKMKLATLTEEEQHNQMKIVDITDHNLKHSQQRKLSKETDPDKTLSQMRRRSRAASGNLESVVVAATNNINTVPRNKSEGRIHERFDRISPRNFDPRYSPKLGEDFPRGHERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG29</accession>
    <name>A0A914YG29_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YG29"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19255.t1">
        <property type="protein sequence ID" value="PSU_v2.g19255.t1"/>
        <property type="gene ID" value="PSU_v2.g19255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="9">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="309"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19255.t1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50199" checksum="5BDA61445ABEE353" modified="2023-02-22" version="1">MAASANNNPATFIGSVKLLNTEDKQANLFNYVTKSCEEFANSENLNALNKILAELNPTQFSVPAFAILSTKFQIHGKYNLDELKATIVKLKSMTSAVKRESISSKFPTFYFYALKFLADACLAKKVPLLGIKPLFEGINWYTNGHPELLTPAHSAFLCLCLKARHFYLCDQFINLDPEMLLQQGLDYRRSNKQNSSLMSCGSEPILLLFYYAALIRVAQCRYEEGLLLIEQLLCIRGMCNSSIAIEAFKVAIIVALILGHDQLFLPGCRNVKFLQSLSRPYLTIAYIVTSAKIGDNIPALVKDYAEKTRKVFQQDGNAGLIDVLVRKLQEKKISDMPKTFMNVDRDRAMTRAFFNDNDNFDAVVRKLINNKELKCTIDGGADIYRFRKLVEDEEDSAEDEIDLNTQLQNLANLTTAVRNIHDRLKVVPQNASNSGKQQAKKRLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH24</accession>
    <name>A0A914YH24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19617.t1">
        <property type="protein sequence ID" value="PSU_v2.g19617.t1"/>
        <property type="gene ID" value="PSU_v2.g19617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19617.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7792" checksum="871F0C2DB56D7C12" modified="2023-02-22" version="1">MDIGDDVTEICKTEFKGLKGESMQFKVYGNNFSDFKVYEEDGMYTAEVNIFRQTIVHHLKYCSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHP1</accession>
    <name>A0A914YHP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHP1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19847.t1">
        <property type="protein sequence ID" value="PSU_v2.g19847.t1"/>
        <property type="gene ID" value="PSU_v2.g19847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="1">
        <location>
            <begin position="133"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19847.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30828" checksum="4A2AE7C29FEC1B5C" modified="2023-02-22" version="1">MTAAAAAEQIIIFKANQEEFKIPLRFFLYQSSAAEPAKTPSLLGGTINLAEYDVKVVKIFVARILEPLKSYKYEFSIIRELYELAQIFQLSRLTKEIENQILSSADNLIIDEFGQYLLLLNDTEISLTKFGADLLQKVIAKFDQLSVTDYLSNLNGAILIEILDSCELFVDSEVKIFEVALKFLKKSKDRLLHVYSILSCIRMARLNDAQRKEMLKALKEEIEPQQASQVLTIAGFVFNEENSYRCCVLKGHEKNPRCMDIPPELRGSVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI42</accession>
    <name>A0A914YI42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18477.t1">
        <property type="protein sequence ID" value="PSU_v2.g18477.t1"/>
        <property type="gene ID" value="PSU_v2.g18477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18477.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19241" checksum="1498FEC2BE799299" modified="2023-02-22" version="1">MEIPHKFVFVKWIRCFLICLTTAEFLLLNFLYFSGNSSYNFGQFLTNSLMSAVIYGPVSTGVSGCVRHLQYFMNDSKLLGISRTFSTVICALLRIFFHQEFLAETPSILKYIFYAIIILSFIDNLILFYAVLILPPVQKPSRQQQFFLVDNVQRSLITRWPNLAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIA3</accession>
    <name>A0A914YIA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17047.t1">
        <property type="protein sequence ID" value="PSU_v2.g17047.t1"/>
        <property type="gene ID" value="PSU_v2.g17047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19088">
        <property type="entry name" value="AKR_AKR13B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007695">
        <property type="entry name" value="PRK10376.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17047.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="16728" checksum="345D2A3FD3D34BAF" modified="2023-02-22" version="1">MGDGHGPAEGSIEASLTVLAEMQQQGLVKHIGLSNVTPTQVAEARKIAEIVCVQNEYNIAHRADDAMIDALAHDGIAYVPFFPLGGFTPLQSSTLSDVAASLGATPMQVALAWLLQRSPNILLIPGTSSVAHLRENMAAEKLQLSEEVLSTLDGISRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIJ4</accession>
    <name>A0A914YIJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20161.t1">
        <property type="protein sequence ID" value="PSU_v2.g20161.t1"/>
        <property type="gene ID" value="PSU_v2.g20161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="219"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20161.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33393" checksum="D2AD9F5AC0B6B524" modified="2023-02-22" version="1">MSQQQSRQRRTQSPAPSPSAVTPSSTLPVQPTQTQPSGFTALVPGESPNNLYPPPPNHDIEKPSMMTNNAAVVAALQGKCDFPKNKMLMAYTKEVNERGHRLEKQPYYVGMLNADDVAPYLKKVGDFGIHACDQEGGQVRLMLTVRGHSGVYHFDLVFDAKGRGWNFHPMPPRCLFHKTVIELVDFHRTSPLPSIPEKICLRDSITRPAWFLKHENVKFDKHDLLGKGNFCEVYRGKLDRRKLIAVKVCRADWRYTVDTVELNTKEKDAREALIKEGSVMSRIRHQNVITVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJB1</accession>
    <name>A0A914YJB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJB1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18937.t1">
        <property type="protein sequence ID" value="PSU_v2.g18937.t1"/>
        <property type="gene ID" value="PSU_v2.g18937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47728:SF1">
        <property type="entry name" value="RAB GTPASE ACTIVATING PROTEIN 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47728">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18937.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14833" checksum="90738B7A2CB03FAB" modified="2023-02-22" version="1">MTRINNCDQCSTALSDWLVESPRRRNGAVPTLDSPDGGPVLTLVDLMGRLEEKQQEIHEIEMELAETKLALVQALCHNQELVGHQMTTSMSSEAGHKPAWFKKTISSIREVGTSFKSAQNHNTNGHTPVTTLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJC8</accession>
    <name>A0A914YJC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19417.t1">
        <property type="protein sequence ID" value="PSU_v2.g19417.t1"/>
        <property type="gene ID" value="PSU_v2.g19417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19417.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19014" checksum="78368D72B8CE16B2" modified="2023-02-22" version="1">MLANYLYGAHAVLFVYDVISATTFENLAEWIERVKSITRNYEKQPIFALIGNKTDMEHRRTVRIDKHNKLAQNSTMNAFYVSAKTGDSVDLCFRQIAGLIMGVNLSKTDLESDISIVKAPVTVCEVEEQPPQKHHLSEAAQPASVGESLPIPPDPKKLNDSSRHSSVCSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJL7</accession>
    <name>A0A914YJL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJL7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19055.t1">
        <property type="protein sequence ID" value="PSU_v2.g19055.t1"/>
        <property type="gene ID" value="PSU_v2.g19055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19055.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11495" checksum="40AEADB1687925C3" modified="2023-02-22" version="1">MVVTGSGLICDSNSACSRASIAQKLGDAVRRRTELETLKSRQEKLLLSVIPAYLTDKVSQSIIANSSTARGLPGKNQKLFHDLHVQVHDNVSCTINRKRSCQNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJP1</accession>
    <name>A0A914YJP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gelsolin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJP1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19739.t1">
        <property type="protein sequence ID" value="PSU_v2.g19739.t1"/>
        <property type="gene ID" value="PSU_v2.g19739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11280">
        <property type="entry name" value="gelsolin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000031">
        <property type="entry name" value="protein flightless-1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000034">
        <property type="entry name" value="protein flightless-1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF51">
        <property type="entry name" value="PROTEIN FLIGHTLESS-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="519"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="634"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="752"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="1166"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19739.t1"/>
        </source>
    </evidence>
    <sequence length="1258" mass="145183" checksum="94CE96D1E6D04A7C" modified="2023-02-22" version="1">MSTGVLPFVRGIDFSRNDFSGERFPHELEQMTHMTWLKLNRAQLERVPDELSRLTELEHLQMARNKLANVHGELSDLPHLRSVIVRHNQIKTSGIPTDIFRMKDLTIIDFSNNSLRDVPSNLEYAKCTIVLNLSHNNIENIPNQVFSNLVDLILLDLSDNKLDVLQPQIRRLINLQVLKLSNNPLNHFQLKLMPSMKTLRVLSLRNTHRNLNNLPPMWDDLENLQEIDLAENDLMTFPPNLHQLKNLAKLDVSRNKISKIEFPEGSFENLRTLNISVNELSAFPEGIVRCIKLQKIYASYNKLVFSGLPGGIGKLIQLELLYLSYNDLELIPEGISRCVKLQKLKLDSNKLITLPDGIHLLPDLKEMDLQNNPDIVMPPKPSDKQKALAYYNIDFSLSHQMKVAGQSPHSSASSVPGNVPKDAVQRKKDFIRRRRYQADQDGASKVIQGMSKIARDKNMNQSEDLPGTQPVMTWKEKMEKTQPKLDYSAFFEEGVGECEGLWVWEIENFNPQLVDEDYQDNFYEGDCYLILKTIKELSGNLTHQIYYWIGEKTTLDKGMCAAVHAVNLRNYLRASCRTIREEMNDESDEFLELFGGEIIYVAGARTQSGFFTVEKTAFVKRLYRATVNGSLVIMEPVPVNAESLDPRFVFLYDCGKTIWIWSGIRSRITVANKIRLFAVRMNKRDRKGKSEIETCNQRKVPEEFWNEFHGSPDAPEEPIVEHVPLDFEPERKKLYNVQIGMGFIELPQVELKSGVLKQNMLQTKSVYILDCTSDIFLWVGKKANRLLKMAGHKLVMELHSMLERPEYTQISRETEGEESTMFRSKFVGWDDIVPFDFTMTADTVQRRGADVKVILERDKMKTDLVALFLDRLPPMSHEDSDQMIMDCNADLEVIEAFVLQGRKFVKLPSNEFGTFYTMDCYVFLCRYGVPNEDSDISDEEGEEGDEERASKSDKTEDKADDFKCVVYFWQGRDAGNMGWLQFTFSLQKKFEELFKDKLEVVRMYQQQENHKFLSHFNKKFVIRRGRRNLTMNSGGKWPELFHMRANGSSLCTRTIQIDCKTDQLNSGFCYILRRPFPIADDEGVNGVVYIWIGNKSESYYHPVAKEVADELINREGDFSMEIINEGEEPDEFWEALGGKKPFETNADFMNYTRLFRCTNEKGYFSVSEKTVDFCQDDLDDDDVMIIDNGELVFLWIGTRASEVEGKLAYKAAQVYIGHMQNKQPDKPRKLVLSLKFHESKRFKRIFHGWSKHKVPAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK14</accession>
    <name>A0A914YK14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17649.t1">
        <property type="protein sequence ID" value="PSU_v2.g17649.t1"/>
        <property type="gene ID" value="PSU_v2.g17649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17649.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30286" checksum="B0C927DE4230737C" modified="2023-02-22" version="1">MTSLRHLTKLINASKINLTSSQICIIRLSSCDSKVFLRQFDYNQIQVIRTVRTGNGRGPTSSSDPPPPPSEDENSFNNKSNLPPNIKNIDPATLKKLKIFSLVVLCSTFGLSFLALRKMGGGGNPAIAEAMKAEPIEFDEFLEHILPTGEIQRVVYVPHQQRAIAFLQPGAMIHGKSYTSDVIPIRIERQNPSQPDQVRLEIRHAEEKLGLPLTEGIPVDTFRGPSFFRAMEFFIGFVIIGFLASRYGQLIRRQILQKRAEDAAAKAAGKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK77</accession>
    <name>A0A914YK77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK77"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19736.t1">
        <property type="protein sequence ID" value="PSU_v2.g19736.t1"/>
        <property type="gene ID" value="PSU_v2.g19736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036941524" evidence="1">
        <location>
            <begin position="24"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19736.t1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36840" checksum="47B2FED825863D19" modified="2023-02-22" version="1">MIFQSKLLLLLILLFPTLKFTSLHDSGVEDGNRRFFIFSSDPLIHFLSNSSHWFVDGTFKITPGISFQLVAVHARYNDTHQTIPCAYLLLPNKTEAVYTAALEALREMVDNAAPETVMVDFEKALHNAFADVFPEAHVSACFFHFCQSLRRHLSELGLTVLIDNDVEMASMFAMFRSLPFVPLEHVVTSFNALKNQILESYGEVNNVAAFVTYVENTYIGELLRNNRRRPPLFSHELWNVFDRTVAGSPRTNNSVEGCHNRLRSFMNFAVESDIIQLDAGVAPRPLSTVWRLLERRRVELTANFDHRDPLSYLRNMARTLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKQ1</accession>
    <name>A0A914YKQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKQ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19459.t1">
        <property type="protein sequence ID" value="PSU_v2.g19459.t1"/>
        <property type="gene ID" value="PSU_v2.g19459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRE1-like coiled-coil containing" evidence="3">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19459.t1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43500" checksum="867204D03E105B04" modified="2023-02-22" version="1">MAEVKNENDSLIQSLQAKIDVLGNDKDELQKAFDEKCDEVKEIKSDAENKRAEFNAELSRLIAQLSKTVAEVREYETEANAVKNEVDELQTEIDSLNLRLIEAEKQKDIDIEILKADLINISAAKDDEINQHKIVAEKEKTELQDELARLNDQLLKATEEIEEYKTATENAQKEIGDLQAIVTKGKEILNARIAEVKNENDSLIQSLQAEIDVLGNDKDELQKAFDEKCDEAKQLKINAENEKAEFDVELSRLIDQLSKTTADAEEYKAKTDAAKKEIDDLSAANEKLKTKISKLYDDLDEADAEKKESSELIFNLTTKLSKYIGEDGAEIRAGIDMGEVMSPRPPPSPDTSFKSVAEEPQPSSSQLDNDDNEKDVTPTKSKGIPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL11</accession>
    <name>A0A914YL11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20038.t1">
        <property type="protein sequence ID" value="PSU_v2.g20038.t1"/>
        <property type="gene ID" value="PSU_v2.g20038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20038.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24096" checksum="5901300392E05631" modified="2023-02-22" version="1">MGIIQKVITSAEQTSTKNNKNNNNKPSNESTKNDKKHETNSNDAIKNDSIPAPTPMNTLVTTSKEKTQTSKETTKTKTSEDGEEKKPAITPPITFSADVLAEAGKGVKRDNIENEYFDPSFFKNQVAMRQHDPQKRPKPLNREILTDQNAGDESNVIRVIAKEVHPVKDKLCYITVKQSAFLGAGAFSGMLNFLKPVLCRTFLIDSDFPVTSGVETPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL42</accession>
    <name>A0A914YL42_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YL42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20259.t1">
        <property type="protein sequence ID" value="PSU_v2.g20259.t1"/>
        <property type="gene ID" value="PSU_v2.g20259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF480">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20259.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32131" checksum="DC493853E866ED56" modified="2023-02-22" version="1">MSNFFNDRDFSSAVIYSSENTPLKMQYRVQEMLTNITITQKTSASRKAKAILRENSKEEPRVKREARPDPPRPPPGSKAADKVTALPGVTFQQTNHYSGYLEAHSGVFLHYWLIETPFNQATAPLILWLNGGPGCSSLGGLINELGPIRPSKDGSTLLENPFAWTKAGNVFFLESPRGVGFSYSSGTEVPADAPYNDTYTAENNVLAVKAFFNRYPEYHNREFYITGESYGGVYIPTLTDALIKTIQNENINYINFKGIAIGNGEMSELLQISSAVNLLYYRGTYDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMT8</accession>
    <name>A0A914YMT8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18643.t1">
        <property type="protein sequence ID" value="PSU_v2.g18643.t1"/>
        <property type="gene ID" value="PSU_v2.g18643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF110">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18643.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13215" checksum="0060E6FACC365A7A" modified="2023-02-22" version="1">MGSYAIAYYFATTVIAVITGIILVLSIHPGDPTIKEDLGTGMDGRNVSTIDTFLDLLRNTFPENIVQATFQQVQTKYVRVRPKILKRNDSDYLAAVANGTFDYFKPSVEYTEGMNVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMX3</accession>
    <name>A0A914YMX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18677.t1">
        <property type="protein sequence ID" value="PSU_v2.g18677.t1"/>
        <property type="gene ID" value="PSU_v2.g18677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21525">
        <property type="entry name" value="Nlp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18677.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9639" checksum="7A9749D208D1624F" modified="2023-02-22" version="1">MVNLKQQLELIDYFGPLICALIFTIILALISLTCLNYCCVSPTDDLTKVEEWGYHHHMHMKLGPHRQSVIERQLRPKYGKVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN69</accession>
    <name>A0A914YN69_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YN69"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20397.t1">
        <property type="protein sequence ID" value="PSU_v2.g20397.t1"/>
        <property type="gene ID" value="PSU_v2.g20397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002014">
        <property type="entry name" value="PRK00819.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20397.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20315" checksum="F72E4C60613139E0" modified="2023-02-22" version="1">MDNQRVINISRKLSYHLRHGPEKIGLKLDKNGWANVEIILSKLHITKTELEECVAKNNKQRFAFDESRQKIRANQGHSIKDVDLELPTTIPPKVLYHGTVERFLDSIMSDGLRPMSRQHVHLSDSIETAQKVGSRRGKPIILKVDTIGMIEDGMEFQVSSNGVWLTAHVPSKYLSKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNV1</accession>
    <name>A0A914YNV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20652.t1">
        <property type="protein sequence ID" value="PSU_v2.g20652.t1"/>
        <property type="gene ID" value="PSU_v2.g20652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20652.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21631" checksum="7B512EF5932B4133" modified="2023-02-22" version="1">MELLKSKWNPAKNFGDLWNKGYEDFTIIVDKKEIKVHKNILAAHSPVFAAMFQPLMKEAIENKVEITDFSYEIVKMAVKLCYHQTYDENISIDESFLLLKFADKYNMANIQENLETYWSGKITISNLCEIANCAAAVNALILQQKCLDHLVHCLKMKYRVPKMELLDKEFIIKAFTKFSYQTSETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNW1</accession>
    <name>A0A914YNW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNW1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2541.t1">
        <property type="protein sequence ID" value="PSU_v2.g2541.t1"/>
        <property type="gene ID" value="PSU_v2.g2541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF21">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2541.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33166" checksum="B12D36285FC4E690" modified="2023-02-22" version="1">MERRLVSSQEECQRLCFEHILKCQSFEFNTITTQCDLYDVPAPEGVLALARSSKLPFSVDDPIDDKKKDISEYSYKLRAKRQIDLQDPLKLPQFPNYCEPEVVPAIGTNFMIPKFECAPSSQLSPTESLLEPFSSSSNSRTRFHVPTSGQNAISIIPDMPDCRDGGRARIQLIDGITLLMEKKPVAKIQVDSAQYLDGNRFPRPCVGATFDRSTGRCTIMDDAITPNGQLQYAPERETVYFEKICIPLAELPANCEDIVHRIPQRVMEGSHDATVDAQTQVECIRKCITASVTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP96</accession>
    <name>A0A914YP96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YP96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19180.t1">
        <property type="protein sequence ID" value="PSU_v2.g19180.t1"/>
        <property type="gene ID" value="PSU_v2.g19180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF175">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19180.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19938" checksum="F81FDA5D9D50F5C3" modified="2023-02-22" version="1">MQDFRISLNSTTNVFFANSEVHGTVYLKTEEPLKARKIEVSIIGRAKAAFNQLRGSISYYYCLSRSYIEIEEILWESDGDTNKIAAGNYQFPFKFVIPINCPPNISATYGNIKYYVQAKIDVPWAFNKNFVAGFSVCPFIDLNIDSRLASPVINYIEKTKLFSSKAVKATVRFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPV3</accession>
    <name>A0A914YPV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SRP54-type proteins GTP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19396.t1">
        <property type="protein sequence ID" value="PSU_v2.g19396.t1"/>
        <property type="gene ID" value="PSU_v2.g19396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19396.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10297" checksum="CBDCDC15030ADA4F" modified="2023-02-22" version="1">MTGGINKRRIIHRTVFTELVKLVDPEVEPFHPTKGKPNVIMFVGLQGSGKTTTCTKLAYYYQKKGFKTCLVCADTFRYKIPDTFFWQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ52</accession>
    <name>A0A914YQ52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2307.t1">
        <property type="protein sequence ID" value="PSU_v2.g2307.t1"/>
        <property type="gene ID" value="PSU_v2.g2307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="341"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2307.t1"/>
        </source>
    </evidence>
    <sequence length="496" mass="57426" checksum="C881228331BC2CD7" modified="2023-02-22" version="1">MLEYPFSMEWTISEERLKQNSTENGRLKSDEFIAINASGVRYSLRIYPNGHNDKYRGKTMIFLNLELGNEKKVEAEYTFSIKTANWSHKIDYIFNENTGWVEGILKIENVESKTEMELLKLKWKTSKNFGDLWNMGFEDSKIFVERKEIKVHKCVLAFHSSVFASKLNTPIFVTQPSLFSSMFVSSVKKVVENKIEISDFSFDIVQKIVKLCYDYDLVSDISVKEAILLLKFADKYEMKFIKGNLEVYLGDRISVSNVSEIENCAIEINSSKLKNQCMDFFINCLSMKYQVPNMKLFDEKFIIEAVTKFCCNTSKNIKIETNESKWSTSKNFKDLWNIGGENFTIITDGKELKIYKCVLAFYSPVFAAMLNNSIDIADFSYEIVEKAVKLLYHRDLISDISVEEAILLLKFAEKYSIEMLKKNLEIYLSDKITVSNVCEILNCAVAVNSLMLQKMSGDYFMECLSMKYRLPNLELLEKEFLIDAISKFSVHKCQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQM7</accession>
    <name>A0A914YQM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2325.t1">
        <property type="protein sequence ID" value="PSU_v2.g2325.t1"/>
        <property type="gene ID" value="PSU_v2.g2325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943">
        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF248">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2325.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40542" checksum="B192BE919884761A" modified="2023-02-22" version="1">MMMNVTQEHSYWMPLKTILHISDWFSGILALCANFFLIFLIITKTTNELKVYSRILIQSCLVDITFAVITLITNSQIDFNGGIILMTMTGPFRHQPNPITFHMINIYIVGLFSCVMFLPIPFIFRYFAVCKSRVLTAFEYAFLILLCFTISILYTCLHAWTFWPRGDLTKYSYIIDHPFWKDEDGTLPNFVAADFKDGRLFILVSCTMILGTISYLLIIAFNVLIYRKLTSLKSTMSAKTCEVHRQLSKVLKYQAMVPFFICVMPLSLVFLLSAIGTKTDGKGVILTMLVSYLPVMNSLSTILFVRQYRRTITQTRLFRIFCPNRAIQDRTSVERTSYIKDIRSMMSRSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR49</accession>
    <name>A0A914YR49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR49"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19856.t1">
        <property type="protein sequence ID" value="PSU_v2.g19856.t1"/>
        <property type="gene ID" value="PSU_v2.g19856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19856.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29184" checksum="EAAA865D3E68897D" modified="2023-02-22" version="1">MSPPQRFNTIRSPQTPKFVRGNQTRPGESFFKSSPSPLRRFKISHSSTPLSDKFGKNSSSRIEYRFCGNEPLPLATTTTLSNIETNLNQTNSSANDSGFGGSLNDSSLLSQNLSWDQSNIFGDCNLLTENTFSDPFNENLWEYSTDSFVSQASTTENQFFTTPLSTSFKSQGIDFNASNDFTPAPPSVSSITSANVTVSMALEIENEQKAAKLKQKTLEDEVLNSLDQYHDEPFNLEYAKDLDMTEFKKLKLVGFLHKNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRV5</accession>
    <name>A0A914YRV5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="4">PARP</shortName>
            <ecNumber evidence="4">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YRV5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20126.t1">
        <property type="protein sequence ID" value="PSU_v2.g20126.t1"/>
        <property type="gene ID" value="PSU_v2.g20126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF117">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20126.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22252" checksum="9E04381CEEC90240" modified="2023-02-22" version="1">MISDLDLYIRNSAQNVKVTGIYSILSKAGVEFFDEKGRKGKNHKYLWHGTRPENLLSILKLGLLATPPHAIQTGNLFGEGIYFAETFVKSYNYCTESSKGQKYALLCEVAIGSVFTSASLYDLQTTTSADAKNKDTLKIAGKNIPNDKFEVTAPTGVRLPLGEMQRNETLDTNWGAMEYSEYIVKDRSNVIIRYLVSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS17</accession>
    <name>A0A914YS17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS17"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2449.t1">
        <property type="protein sequence ID" value="PSU_v2.g2449.t1"/>
        <property type="gene ID" value="PSU_v2.g2449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2449.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20116" checksum="EE29CBB1FE93EDD6" modified="2023-02-22" version="1">MTKPGIRDSLVNMLGEFVGLSRNPEFRLSTSSEQFLADAIKEEKKASTCSIASSDGSLNIYIGMDPISHQRSNSTPIRRNFTKTIQDSEESRRLSVPLLRPKLLLKRFKRHSGSYDPNPINTTVISTPRKNSIISESDEEILAELPKSKRTRNYSQSSSILGDLAKSGHVRCQPLMVSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS53</accession>
    <name>A0A914YS53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2842.t1">
        <property type="protein sequence ID" value="PSU_v2.g2842.t1"/>
        <property type="gene ID" value="PSU_v2.g2842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2842.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21865" checksum="E7F40A9071518B4C" modified="2023-02-22" version="1">MEFVGDLSGITTRNKPNATYQSMIDGEMVYEYAIHRYNKKKTKASFRCAGCRSAIDDGRNPEFKIYYLKGAVDYESKIVRFDENPDMHPHCCERRHPFFVKGKQLRREVRNEIKGSGVTGSECIKNFNKKVKEKEEDGDHDGVMSRIGTTEALRKTLKKAAKPNFVQHCAPTDIDPELKNHLFPMDLTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSG4</accession>
    <name>A0A914YSG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3106.t1">
        <property type="protein sequence ID" value="PSU_v2.g3106.t1"/>
        <property type="gene ID" value="PSU_v2.g3106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3106.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13132" checksum="4B4B8B85133B7732" modified="2023-02-22" version="1">MELLLATNKFQKILKIQLWDVDRTDPDDLIVEGSLDENGEFFLQGSETEFSTIDPELRIIHKCGDDGVECFRQTIIDIPDDYISDGENPTKTFDAGNINLRVIPNTETSECYWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSN2</accession>
    <name>A0A914YSN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSN2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3166.t1">
        <property type="protein sequence ID" value="PSU_v2.g3166.t1"/>
        <property type="gene ID" value="PSU_v2.g3166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3166.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36198" checksum="7562B120FBCE6329" modified="2023-02-22" version="1">MMHQIHSFNFSADSLSTQQERVKLTDSLFAVLGQNPDVHAHIVNIRPLTEILCEVEIFVTKVGSGKINAKELFAYLDHPDRANIKKEKLLQCVKIVPRVEMNHEDIKRYLSSPPKGFSENEWRQAIVDNPDQQNLLPYPIYGYKELDDRRQRQLKERDTQRKSLGNLNDRLKTAAQDIQQINGLKHMFNEDAKRLRYRILRIIAASHNNSYQNAVSVEEEKLLSRLETIAVCVNAPNRLHDRIENLHDFLRSNKEGLENRKKEASDHQSLSEEESAALKRYLNRRQQDLDIISDSLQNNIDDVQIMLKEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTZ1</accession>
    <name>A0A914YTZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTZ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20922.t1">
        <property type="protein sequence ID" value="PSU_v2.g20922.t1"/>
        <property type="gene ID" value="PSU_v2.g20922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20922.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12059" checksum="36AF3AF757F4ACD7" modified="2023-02-22" version="1">MLIKLYKHRLRLSEVKKLENAEPLDYRKMAKMYEKIADFLCEIGAHELAIDFYMKMKNAAALLPGDPEFGDLEISRAAILSIAQTYGNDLSEYEKASEFYEKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU05</accession>
    <name>A0A914YU05_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YU05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4139.t1">
        <property type="protein sequence ID" value="PSU_v2.g4139.t1"/>
        <property type="gene ID" value="PSU_v2.g4139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4139.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27490" checksum="08F2023F74C19939" modified="2023-02-22" version="1">MAANEDILPPGKIINLRWKVDKKLGKGCCGAVYKVIDLEKKPPGKAALKTEKHGDDKSLAVLKKEVDVLQKLKERKHVPRLICSGRRNEYDYFVMTLLGKNLFELKKECNAGVFSAGCVSRVAVFVLYGIKQLHEIGYLHRDIKPANMVIGRGKDNRIIYVIDYGMARKFGIWENGVVRHRKARDSVLLRGTHRYCSPFVHERIEQGRRDDIFSMLYSLIFLHIGTLPWVGIKDVCFFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUT2</accession>
    <name>A0A914YUT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUT2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4375.t1">
        <property type="protein sequence ID" value="PSU_v2.g4375.t1"/>
        <property type="gene ID" value="PSU_v2.g4375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4375.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17037" checksum="82FD5505F33460D4" modified="2023-02-22" version="1">MSINLQHAFRSFTRSLLLKTGRNFNYLTSDNNSNNNNSCNEENDITLVFIVEDGTQFLVMGKEGECLCNLANKYGFDIHDPVTCILLDPPTVYYADNMFYNNLPGPGQSKLDKELIQLRPKKQELRAEMPITKEFEHYFINCTKLNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUX9</accession>
    <name>A0A914YUX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonucloprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4415.t1">
        <property type="protein sequence ID" value="PSU_v2.g4415.t1"/>
        <property type="gene ID" value="PSU_v2.g4415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="188"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4415.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32791" checksum="118DCC114552899F" modified="2023-02-22" version="1">MLHLQESTPAKVAPKVPKAVLKEVETSDEDVAPAKKVTPIEPAPANAALKRKNGETAFDKNEPSAKKADTRRKSEPFRRVTGSINDIPENVRDNSYQNKADPWGAKANEDLKRVQGKNFRHEKTKKKRGSYAGGKISLEMKAETVDVSMNESAVDQTGPSTDKDVYAELCGVVNDIAQPLANRKLAKKLYKLVKKAAADKSTIRQGVVDILKAMRKNEKGIMILAGNVSPIDIYSHIPVLCEDNNIPYVFTPSREHLGLATGHRRPAIVLMVKRSEEYGELYDELHEIVSNLVIEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV12</accession>
    <name>A0A914YV12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RZ-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g3812.t1">
        <property type="protein sequence ID" value="PSU_v2.g3812.t1"/>
        <property type="gene ID" value="PSU_v2.g3812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="13">
        <location>
            <begin position="1855"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="878"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3812.t1"/>
        </source>
    </evidence>
    <sequence length="1943" mass="220599" checksum="1F16A4FC48A9D409" modified="2023-02-22" version="1">MFGANPDRGRGSSSRRRGIGDERGNRGNGRGRGNFHGGPLGTPFRGNYQQPGRLNNQRYNNLQHGRTNYGCNDFKQDGIPYKDIEQLCADMDSMKVLSGSSDLLKFVQGKGFSNRLNNIWTEVEKQTKFLRVIVSTASSSQADMLPLTYAFLGEVLSSKLVEAIVDTISPLPYNKQMQQNSIYAELVGYTVKLLLLGFECLPSKMDIHLTKVHVVITTLNGLTTFLSAETIYDLEGLKERIQERYTAKTEENAKEIQERQQNKRKDDNHGAPPDDFRNLSLIPTTEDMDNNNFVYLRPAKIDGKYDSDEHYLDVQFRLLREDLIRPLREGIAGYQGGGAQNSDLFVYRNVSLEPPVMYQQTGELVVYANIQILKRLRMNKRLINGSLICLSSDGFKNEFLFATILDRNNILDAKIGLKFEGSLDLNFKRTYSMVESPAFFDAYRHVMTALKNKIPPNKNILTAQNFQRYLTPAHLGMDQSQFDALANTLQSDLAIIQGPPGTGKTFMGLQIANLLISNPRLWQSVTDKRPILVVCYTNHALDQFLEGISHFLHEGIVRVGGGSKNPNMQQYMIHKLRKWDDLDLKHSSFELRTEIADLQIELEVIAEDLKDLSSRFVHPNDLQPYFRNKNLPYFRSCQSLCTKVNNTETFIMSSWLTSFKLEDDVPFDVKIIQQLMKKRIPEIQAKNALLCTYYSNLEYDSQSIFENLKNGIYGTLSTSQLMEGIEHWPSMRQVNDLVRQGFDANIAAEILISSNNDMQIVYREIGLVQNFLGNRRPVAPQLPNPKEETKEQLTEIDVKADDDNNRIIVDNNFMEEINAKRKKAKKIWYDKNAIKPALEHIVNTPGMTNEEAQNITDIWQLPLQTRWRLYQRWISQSRNKLKGQLKRIEEKYSEKVKEHQALKTMVDVEVMKKAKVVGMTTTGAAKHQSTLRTLRSRIVIIEEAAEVLEAHVVASLTIACEHLILIGDHKQLRPNPAVYELAKKYNMDISLFERLVKNGFPYRMLSNQHRMCTDISRTLMPHFYDSLHDHPSVLKRESVIGVTKNLMFITHSEPEISEKDFKSHNNPFEAKYALKLAKYFLQQGYKSHQITVLCTYLDQLLSLRKASPNIIGELEKITIESVDNYQGEESDIVILSLVRSNNPEGKIGFLNIPNRVCVALSRARMGLYVICNLDFLSARSEMWKNIQKGAEEVGALDDSLTVECKMHRKQQLITRGEDFDEKCPEGGCDDPCNTRLNCGHMCPKPCHAEDMNHLETKCLKPCARTCSSEHKHRCKKRCHQECGSCIVLVEKQLPCSHTKMDQCYLKPEHVRCVEPCQKSLPCNHPCTNFCGATCTKQCAVLVKRKLPGCEHIVTMKCSDDPSTVKCKEVVLKKWPICNHTVNVYCFVDVLQYLCPKPCNAVLPGCGHLCKGRCGDCRNGRLHIRCNEKCKKILICGHECESKCSNSCPPCQKLCQTACAHSQCGKLSAFGENPKKVRQKAGKKCDKSPTGNRLCGDPCPPCVEKCLNRCPHRICDNNCNDPCNVVPCNEPCNKVLSCSPKKHQLVAYEEEKDDADSSSSAEEDEDDEHYCIGVCGEECLEICKICDSEKYEEIQEVFFGTEEEEDAKYIQLKDCGHIFEVSGLDQWVKSKLPNNDSNTIEIVEILCPRCKTPIRRSKRYISLLNQRSVDIEQIKLQIRGLTVAEKKDEQKKFSEELNIIIPEVLLVKQLLELRGHALGQLKPLVGQELPATTTEQSSLHYCDAIKNGFQITDFSKYLSKEIINLIFRIDVKETSETIIQQLSNEVSRYGFLCNVFVYMNQLYKAKNDLDHENANALYKILGSSFGSIEFKGDHETKIWEDFKAIVEAHPAEGFGISEKERIEIVKALDGAVTKWYKCPNGHMYGIGECGQAMVKTKCPECGTVIGGQNHQLQAGNSDATAQMRQGLAPLHIPDPFVVREGPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWJ1</accession>
    <name>A0A914YWJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g245.t1">
        <property type="protein sequence ID" value="PSU_v2.g245.t1"/>
        <property type="gene ID" value="PSU_v2.g245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g245.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30723" checksum="71B86831F22F56D6" modified="2023-02-22" version="1">MQAVIIERLNKFEAVDDRQYFQEYERYKTSLNQKYSLCLHCQEYTNRKLQSINERYIPRLESSVEKLLLLNPFAIARDTLPSFSSSSLISESSSFAQSVFSESRRAPSMCSFSSSRAPSPFGQRNLAPSFFSEPIHSHTFIQSSSESPSSIASGFPDKTSLSRIPSVLKHEQHSFQKLNHIHKNQRQKLYFASGKNTVACNILTLIISFILFITFFDSSQISSNVRFLALEEYLSMDTVNALHICTNYASIIAAFTSALFYYGFNLSKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWL5</accession>
    <name>A0A914YWL5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative complexin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Positively regulates a late step in synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complexin/synaphin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWL5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2473.t1">
        <property type="protein sequence ID" value="PSU_v2.g2473.t1"/>
        <property type="gene ID" value="PSU_v2.g2473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22808">
        <property type="entry name" value="Complexin_NTD_CPLX_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.580:FF:000002">
        <property type="entry name" value="Complexin, isoform AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.580">
        <property type="entry name" value="Single Helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705:SF4">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2473.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15767" checksum="41AC6CCCB8760E8E" modified="2023-02-22" version="1">MNFVVKQMVGSQFKEMTDGLGGGENAEQPQGEDPEVVAARKEQEERRKEKHRKMEVEREKMRTDIRSKYNITKKEDGPQFDIGADGRIGAARKKTPEELAAEMEPDDSIIGQLGLTEHVEKAKTAANSAFDTIKGFLPFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX14</accession>
    <name>A0A914YX14_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YX14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2620.t1">
        <property type="protein sequence ID" value="PSU_v2.g2620.t1"/>
        <property type="gene ID" value="PSU_v2.g2620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2620.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28696" checksum="97CE504C37478C8E" modified="2023-02-22" version="1">MFRNQYDSDVTVWSPQGRLHQVDYAVEAMKQGSATVGIKSNTHVVLVALKRAANELCSHQKKIYELDDHCGLSIAGLLSDGRILARFLQAECSSWRWDFKENVPIQVLNSHLALKLQANTQYYGRRPFGVGLVIAGYDRNGAHIVQSDPSGEVVEVLATSIGARSQSARTYLEKHLDQFKTATLEQLIEHALLALRDTLPQEDNLSKKNTSISIVGRDTPFKAMDDDEVQPYLERITNIPRAGQQEQAVPGEEAMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXZ3</accession>
    <name>A0A914YXZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4969.t1">
        <property type="protein sequence ID" value="PSU_v2.g4969.t1"/>
        <property type="gene ID" value="PSU_v2.g4969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44115:SF4">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44115">
        <property type="entry name" value="PROTEIN CBG09704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4969.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15852" checksum="D9F0523202991ED7" modified="2023-02-22" version="1">MNIIQLTEFAIPHLEKTKGNIVNVSSIVSQKTNQAFPFYNISKAALDHFARNYACLLATKGIRVNNLNPGATNTAFLSRHGITEEMKEKMSKNFSIPLGRWGTSEDMAEFLVFMASEKASYMTGQMINVDGGILIDSPSFKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYV2</accession>
    <name>A0A914YYV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYV2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5288.t1">
        <property type="protein sequence ID" value="PSU_v2.g5288.t1"/>
        <property type="gene ID" value="PSU_v2.g5288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5288.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="31319" checksum="4F7915EAF0290C06" modified="2023-02-22" version="1">MAALRNATASNAQILVALSPPPNVVVVGGTSGIGRGIALSIGKHAPGANITIIGRNQSAADSIISTLGSRAKFLSADASLMSEIRKVTKNIDAVDIVVLTQGILTMNGRTPTAEDIDTKLALHFYGRMLFVQELLPLLRQSPLGGKVLFVLDSVNGGPTKVNWDDMALEKSYSLMGAAMHATTFTDFMIQYFASQSENENITFTHAYPGAVKTTLMDNLPFYARIPAKFGMALGIGISPEECAEYMVHGFLGTEKGFRYVDNKGETVTKTKSIDSDMANKVWEHTSQIISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZM1</accession>
    <name>A0A914YZM1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="21">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZM1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5548.t1">
        <property type="protein sequence ID" value="PSU_v2.g5548.t1"/>
        <property type="gene ID" value="PSU_v2.g5548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 21" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="19 21" id="KW-0804">Transcription</keyword>
    <keyword evidence="11 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="23">
        <location>
            <begin position="234"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5548.t1"/>
        </source>
    </evidence>
    <sequence length="1208" mass="136288" checksum="ACE0238C3478F86B" modified="2023-02-22" version="1">MSIFNSDFRAPLRLVKRVQFGILGPDEIKRMSVGLIEYSEIYENGKPKLGGLMDPRQGVIDKRSRCQTCAGNMNDCPGHFAHIELAKPVFHIGFLTKSLKILRCVCFYCSRLLIDKDSPKVKDILSKTRGSHKKRLTMIYELCKTKSCCEGDDGPEEGEEMLEDRINKGGCGRYQPSYRRTGIDINAEWKKHVNEDTQERKIVVTAEKVLEVFKAISDEECRILGLDPRFGRPDWMICTVMPVPPLAVRPAVVTFGSARNQDDLTHKLSDIVKTNNQLKRNEQQGAAAHIISEDIKLLQYHVATLVDNQIPGLPTATQKGGRPLKSVKQRLKGKEGRIRGNLMGKRVDFSARTVITPDPNLPIDTIGVPRTIAQNLTFPELVTPFNIDLLQDMVMRGDKSYPGAKYIIRENGERVDLRYHPRAADLHLQPGYRVERHMRDGDIIVFNRQPTLHKMSMMGHRVKVLPWSTFRMNLSVTTPYNADFDGDEMNLHLPQSLETRAEISEIAMVPRQLITPQANKPVMGIVQDTLCAVRMMTKRDIFIELPRLMDLLMYLPSWNGKIPQPAIMKPKPLWTGKQIFSLIIPGNVNVMRTHSTHPDSEDNSDKKWISPGDTRVLIENGVLLSGIICSKTVGRSAGNLLHVIALELGHEVAANFYSHIQTVINAWLIAEGHTIGIGDTIADQQTYKEIQDTIRKAKDEVDDVIEKAHNDELEATPGNSLRQTFENSVNRILNDARDRTGSSAQKSLSEFNNFKSMVVAGSKGSKINISQVIACVGQQNVEGKRIPFGFRHRTLPHFIKDDYGPQSRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVNYDGTVRNSVGQLIQLRYGEDGLDGMWVENQTLPTMKLTNGLFEKKYHLDVNNDKELKKLYTDDIVRELKGNPDAQELLEDEWKQLSQDREMLRTIFPKGDAKIVLPCNLQRLIWNAQKIFHVDARKQSDLHPQAIIEGIRKLSDRLVIVSGSDSISKQAQINATLLMNILIRSTFCTKQVAETHKLNIEAFEWIIGEIESRFNQAIVQPGEMVGPLAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKEIINVSKQPKTPSLTVFLLGETAKKAEAAKDVLCRLEHTTLRKVTANTSIYYDPKPTDTCIDEDREWVSLFYELDPRNVDSVSPWLLRIELDRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZR8</accession>
    <name>A0A914YZR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZR8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5119.t1">
        <property type="protein sequence ID" value="PSU_v2.g5119.t1"/>
        <property type="gene ID" value="PSU_v2.g5119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5119.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20460" checksum="59ED32CC1039982F" modified="2023-02-22" version="1">MTATGPRHKEIWSPVIENEKNETLDLSTSKTLINSMEHPLPFPPFQLPSVFPFGHFGLTRMPLIMPPLNQAFLAMCTKSFQQQLSKPHQSEIKKVTKLACLPSKKNAAAAVTPNPIVNEILKDSVPEQQHSINHNVCAVCGEGFRLTGDLVHHMRREKCRWTPKSSSDVATTAPYQIPKRGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1C0</accession>
    <name>A0A914Z1C0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1C0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4066.t1">
        <property type="protein sequence ID" value="PSU_v2.g4066.t1"/>
        <property type="gene ID" value="PSU_v2.g4066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4066.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7986" checksum="C838C2632734062F" modified="2023-02-22" version="1">MSSIRFLLPSFEELPDFADVVYLEDSGYIPEVERDGQNRLIKAFGTIRTIKKGTHVSQKIRDQMKQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2K6</accession>
    <name>A0A914Z2K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2K6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4486.t1">
        <property type="protein sequence ID" value="PSU_v2.g4486.t1"/>
        <property type="gene ID" value="PSU_v2.g4486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4486.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15017" checksum="5D68545AD2F21160" modified="2023-02-22" version="1">MATKLGFFEKIANLTGVLYRHQAKQFPRRLDILTKVAKRELAPPKTTDWPIIKKEFLAVVKAIESREFRNLSVREAAVYVAVGMEIVFWFFIGEMIGRWHIPGYLVPATYVSKETKKQVASQKAEEKDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2Y8</accession>
    <name>A0A914Z2Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2Y8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6424.t1">
        <property type="protein sequence ID" value="PSU_v2.g6424.t1"/>
        <property type="gene ID" value="PSU_v2.g6424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6424.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16314" checksum="ED901CCE3E15E5F7" modified="2023-02-22" version="1">MFLCPGLPEFFMRANDFENLEAIFRSKETGFCNREAFTDDDLEAWKYTYAKPGALSPPMNYNRATMLQFYPAEFPQPILQPKTLYIWGQKDGFLMNEGGDLSIKLCKNARLIKIPNASHWVQQDAHKEVNKHIQEFLAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z357</accession>
    <name>A0A914Z357_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z357"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7127.t1">
        <property type="protein sequence ID" value="PSU_v2.g7127.t1"/>
        <property type="gene ID" value="PSU_v2.g7127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7127.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8033" checksum="4A608F5FDB66EDA3" modified="2023-02-22" version="1">MIAEREQCGQLRRAVSECDIINSIQIGMNMQRSIQRCDEVGGIIDQNPTAVMDGMNSMINGEVAQGFINNFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3V5</accession>
    <name>A0A914Z3V5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase II subunit beta</fullName>
            <shortName evidence="2">CK II beta</shortName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6688.t1">
        <property type="protein sequence ID" value="PSU_v2.g6688.t1"/>
        <property type="gene ID" value="PSU_v2.g6688"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6688.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24670" checksum="00C297E866EC5B5E" modified="2023-02-22" version="1">MSESMTSDSDESAYEYLDWFHSLKTTKFMCRIDEYFLEDAFNRTNLEKELLFAISENTVAKFIRHIKYDTSVSGYDLDEIEEIAADVYGLMHARYILSSAGLKDMKKKYERGEFGHCPRDKCNEQKVLPIGETELGEGFVNIFCPKCREIYFTKSKFQLDGAYFGPSFPTAFLMEFPEILLTPHSTIKPSPECITTSDSSESSSERSSSIKSVASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z489</accession>
    <name>A0A914Z489_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z489"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7510.t1">
        <property type="protein sequence ID" value="PSU_v2.g7510.t1"/>
        <property type="gene ID" value="PSU_v2.g7510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7510.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26788" checksum="E8C96359D97CBED2" modified="2023-02-22" version="1">MDEWRTITLTCISTGLFLIASLSIIISMCDRKKKKSQAQQVPGKSVTPKSAFKPAQPPSSAKNPSSPLPGEGRNKNDLQAAQNQKNALAKSKNERKSVRQASNKIFAGALDKTQEESKRSAKSNSKESGENNNNNLNKKEEQTGAKDTEKKDEEEKKSTEPPPIVPEDKVQVLGNLDDVIKEKKTQLVKEIEDMGSAHEHDKVEKEPLNPEKHVVINEKKCKLYTTNNEETKEDDAPDDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z545</accession>
    <name>A0A914Z545_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z545"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7018.t1">
        <property type="protein sequence ID" value="PSU_v2.g7018.t1"/>
        <property type="gene ID" value="PSU_v2.g7018"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7018.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23628" checksum="DF540F3791F98B17" modified="2023-02-22" version="1">MLGGNTAGGNKNTTTNHYAYYSSKKPITENVAMVVSPYYQHSSHSCSITFRYRIIGGPGASIIVSTQLIPLHAISSEETTEEEAADWVNPTVRKIIPSTKSEAILTNIGIGEVGYPTRIRIECHSGESKNTNIITECFIDDIRLTQCEEHIWQPNVCSMDSQPKRYLCHKFAEQKCIDFADVCDMHDDCPNREDEDNTIHNCIQNVGDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5B9</accession>
    <name>A0A914Z5B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5B9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7089.t1">
        <property type="protein sequence ID" value="PSU_v2.g7089.t1"/>
        <property type="gene ID" value="PSU_v2.g7089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7089.t1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39821" checksum="734D60D7CC19434B" modified="2023-02-22" version="1">MHTLETEVKKQSIVQNKQTSNVPLPAGTTSHKESVFLKLNKRLSNLELNISLSSQYLAELSKQYVAQTEENRKNYEKTSKYIEEAISRASVTLSKQFGDEILKIQKEVKELFTHFHAHPSTSNVPGPFEKAYHSGSLVIHFPVKEHCSSSDYDNIYLDKSDGLWTTQQLVVVIAVMQATTFGMMFVLQYLWKSSSQISQKVVIISSDVDVKKIIAAEVQNELKEQHQKMQQHLMMARTTTALILPNNTCSSSSEHPTPSTPSPPVATSSSPSKKRRKKKRNTNSANNFSIPPSDKWDSTSVSSSISAPSTSVCSSTVTSMSSLLKKKSSTASRDSCFTSESTENASPEQHLFPPFLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z655</accession>
    <name>A0A914Z655_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger ZPR1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z655"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8162.t1">
        <property type="protein sequence ID" value="PSU_v2.g8162.t1"/>
        <property type="gene ID" value="PSU_v2.g8162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="5">
        <location>
            <begin position="248"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8162.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45492" checksum="63CDE68D18E6C5E6" modified="2023-02-22" version="1">MANSSVEEPEIIFKDLSADDGDQVPMEIESLCMQCHENGTTKLMCTRIPYYKQVIVISFLCDHCGFRNNELQSGESVQEFGTEIVLNVKTKEDLNRQVVKSEYASIEIPELDLVIPYKSQPGEITTVEGVLMRVKNGLEQDQDRRIQEHPEAAAQIDQFITKLMSFATLEKHFTLKLNDPSGNCYIQNPNPLHVDPRCIVSHYYRKLSDNKILGLSDDNDEEEDPKIVAEREWKSYEDVKQEVLRFHVDCPGCGAPVETCMKPTDIPYFKTVIIMATSCDTCGFKSNEIQASGPTQEYGCKLSCQITDELDLARDVLKCDTCNMAIPELEIEVGYGALSSRFTTVEGLLQATKEQLEEQSRFFMGDSAVDADDGTNKRTMQNVLDGIDEILALKRKATLLNGSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6T0</accession>
    <name>A0A914Z6T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6T0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7615.t1">
        <property type="protein sequence ID" value="PSU_v2.g7615.t1"/>
        <property type="gene ID" value="PSU_v2.g7615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="53"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7615.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14264" checksum="E65DC0DFAB1040E6" modified="2023-02-22" version="1">MSDQELKERLMSYQDFERDVKLGIESSLTEDKNGDVIFDKLSSSSSSSPWKGRPAFLDWRTKGKVTRVKDQGQCGSCWAFSVTAAVESQIAIKRNELIELSEQQLIDCDSDNRGCSGGYRPWAFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z761</accession>
    <name>A0A914Z761_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z761"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6088.t1">
        <property type="protein sequence ID" value="PSU_v2.g6088.t1"/>
        <property type="gene ID" value="PSU_v2.g6088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF6">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6088.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37156" checksum="353A272F934D52AA" modified="2023-02-22" version="1">MFGFLAFNGGSMADIVKPGEGDTVALAMINTIMCGAFAALIYLCIHYLTKGKWTLLLTINAALAGMVASCGGCNRMEPWASVFTGTGAGLIYLGLSKMMIALKIDDPLDAFAVHAGGGLWGLIAVTIIGHDGIAYSIVDAIDGDNSKIGQSFAQFGWNLICALAIIIWSSMIMIPVFLFLKKIKKFRVIPEVEIKGLDIFKHGEAAYPIHAYGHGWDDLVSEDGRSRARTLSAHAEFSLEELAAAYERRTSVIPSQMSRRISYFHNPTAQRYEQPELHQKALKTKTPNPKKLLQKMQFQIRIGPSSNELYASAPINVPQIVVENLDEDERDSDSDGQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7B6</accession>
    <name>A0A914Z7B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7B6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8581.t1">
        <property type="protein sequence ID" value="PSU_v2.g8581.t1"/>
        <property type="gene ID" value="PSU_v2.g8581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8581.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18907" checksum="C861C384BE9D2CD3" modified="2023-02-22" version="1">MPSLKGNSKNLKLIAQEFTLLKNEPEFRWSMDTVEKNSMTNYEFRISENPQSDLIKLQFQNMPETPPAAQYVILWKRIKSVWSTAGIVLLNNGYPCPSYDIGVAINGVNFYCGDVKAHNISYPNFGLLVQHRFQNDAHPNACPPKDPFTPHRLLGRMPRITDYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7Q9</accession>
    <name>A0A914Z7Q9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small subunit processome component 20 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g6285.t1">
        <property type="protein sequence ID" value="PSU_v2.g6285.t1"/>
        <property type="gene ID" value="PSU_v2.g6285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="4">
        <location>
            <begin position="646"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="5">
        <location>
            <begin position="1220"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1501"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1518"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1548"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1558"/>
            <end position="1571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6285.t1"/>
        </source>
    </evidence>
    <sequence length="1571" mass="179344" checksum="6D373F158DE102CE" modified="2023-02-22" version="1">MTKRKGKHFACQFLIIFEFFKKQIFTNVEIECLWKCVIEPIILQHQKSTVEHFIPASLSRFVTSLTKLPMFYPLLIKPFSKASKAETPLSLNLSFLNSKECTALYRNQIVNGIFTLLSLRDEPSAVPELAESKFAVRDEINMGTELILTQLPKIIQFLVANIPTDLSKAKNLPLIYLDILNRLSEFVEDSEVGEHFASTLLSYIENDRIKNEEKITAVLQTISSLVGFVKEPKSYLRRIPRLITSINYRASREALISIVSALSKHSKLSAEKSFIENLKILEDLEAWDKKKLNEPDQERRHQALADLDRLYSFANIKLDPINIVLFVRSHASTVSLVDDIALRSAASSAFSALISYTSKIYADNVPVKQDLLRKHFIPLIANGIRSNNEAIRNEFILAFDILITSFSDCDKQLLIPFKQLQHDDKDLDFFANVTHIQHHRRQRAFKRLVAAMEEKTITLPFDSLMKFILPMVHPYFLLTEPKYAQLVAESLNVLREIMKHASWTKYYRMLSTYIHQLTTVEQTKPYVRVIVAIVDAFHFDLQHCDFKPTEFQMAKNPKRDKRKLGSALRRKNFEEKKVVNEIEKVLGEESNDDEEEMDEKLKDEKEKAKKILEAVLQNVLPKLQDTIKPNHKLLGHKKSHVGKYFTEDEDLKRVPLALATVKLLQKLPEWVLNRHLHNVVVTLITLLLSRSSEVRQSARKTMQQVIQGLGVKHLSFFIKEMKQTLTRGFQVHVMIYTIHFMIQSMEAQLKTGDLDACMDVIVDVCKQEQFSDTTEEKELSTAVSEAKANKTGETYQFLGKFVSYASLMKVVNPMKEIFESKPNAATMKKLSGLLRSFVHGLRSNEGIPPEQLLTFTQKILDSNLSEMTKQLAASQPAIQAEEDRKKMGFRPESCYILPAAPKRLGAIVKTSIKAQASIFVEFGVNLLANLLKVHAFDPKKPEDAKKLDPFLPMIIGCLKTKYEKIIGVSLRCLHGLLKFPLPSVEANKNEIIERLFVILADYAGLGAAGHLGSIQELSQNLFKCFNQMIHIAQATILTPKRLQILLNYCETDILDSQKQATAFALIKSILGKRIKDDKITTMMDYLAELSITSTIPIVRTNCREIIIQYITNYRIVEEDAEKWLSFYLEQLEYEFEDGRLSTLEMINSIINAFTEEVNNKFALLVFIKLSARFVNDESKKCVKFVQLAIQKLLQTTTAKAHHELLSVAKDWLQSDNESTRVIGYKVTAELCRGLPALFASKIEQFLPLMTQQFGELSTTEFSENVVLALFETMTFLCQFVPTAFLKSFILTQKEHAILEKLNEFLQCVLSKPVQFAASGFLGQLLSTLKNEETIKFHNKLQKLFESSVGWSKLCYSLCFQLKGKSLSEATVEQLIKNLVFLSSQITDTEEYNSFCQRIANVCSAEVALYSTESLRRKGIFKLTAACALQNTVEELTKTLTQRMLPSLHREMLGKSSADREDLQNLASEVGEILKKQIGAKEYASILIECSKKANEKTAKRKEEAATLAVTDPRAAAQAKRRKHEKKAENRKRKLDQLKPYRIAKRKARTDIREKMDDAEANFFDDEQEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8T4</accession>
    <name>A0A914Z8T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8T4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8248.t1">
        <property type="protein sequence ID" value="PSU_v2.g8248.t1"/>
        <property type="gene ID" value="PSU_v2.g8248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003677">
        <property type="entry name" value="ANIS5_cation-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052823">
        <property type="entry name" value="SXP/RAL-2_related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593:SF36">
        <property type="entry name" value="DUF148 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21593">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02520">
        <property type="entry name" value="ANIS5_cation-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SXP/RAL-2 family protein Ani s 5-like cation-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8248.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19823" checksum="CECCB59744CD74DC" modified="2023-02-22" version="1">MMFKDGGGMDKKFVKTLDKEAKEKYLAIVKNKNLTKAQAETQLDAFVQTLTPEQKEKYNAMKESRQEHMNKLKAKVAEMMPTFSQQTQKVIREIEAILDDKNLTCAETRERLQQIRKTSPKETQNELRKIFRSLKGGKKGSAQVEGRFDAQKNKFEVPFNNEFEGTIVDTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z965</accession>
    <name>A0A914Z965_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z965"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8870.t1">
        <property type="protein sequence ID" value="PSU_v2.g8870.t1"/>
        <property type="gene ID" value="PSU_v2.g8870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF436">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF7.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="7">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8870.t1"/>
        </source>
    </evidence>
    <sequence length="502" mass="54352" checksum="E0FB962D73D6E479" modified="2023-02-22" version="1">MAHFEPDQANKWPHDQLTRHLAARTSIGIDQNGPSPLTSSFHSNGNFPPYSTANGNNIYPQSSEFDTEDIKPMKEWNEKLWQQNGTSKLSPSDIVRTATPSANSTESTPSSQRHSIGPEEGDQSRTTSTPEIKSEFSELSPEHSTVGNIEVTTNNNKDKDATFSPVTTSSSSTGGPTVSASDQNQLAALRIEEKILYEKLTPQVEPQMTEKKAESIQSVVNSVSSTEFDVEKFAPQTVLPPKPAPSNPIQLQAPTSTTPPRNSRAFFRAPGHGGPTESQDNSKAFVCSICNFSCPSKFHYNSHMNTHGDHQCSMCDYTSRTEGRLKKHMRESHTREEQIAAGLDVPPETPAAVPNTAEFQATMASLMEAAKTAVNNAAAAAASNDSSIGNMNNNTIESGNNSPISSIPSALDSLRALSQGEQANLASLLHMTDASNDSVDTAGPSTPREPPKRSSGGKAKQYPCKQCSHIATSKEQSWFHSRSHIPSDKQLSCPQCEFMCQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9B2</accession>
    <name>A0A914Z9B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9B2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8403.t1">
        <property type="protein sequence ID" value="PSU_v2.g8403.t1"/>
        <property type="gene ID" value="PSU_v2.g8403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06768">
        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF3">
        <property type="entry name" value="NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8403.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23436" checksum="3749A81FFBEF4A6A" modified="2023-02-22" version="1">MVQYPSNGGGYRDLPNDAPPPRLCLIQKRDSSQEYGFNLHAEKKGQFIGAVDAGSPADLAGLQQGDRIFAVNGASIVGVSHKTVVSWIKSDPLKCEMLVISEDDYQWYTENNIPIDMSLPNIIRVCKEFYDIASVSSPSVSEKSSTRHTVRIIKSYESPTAQRLYCTSIEVKSRSLDSSSLTSYSESTQSSMRSTPEQEFDKKVLFMLTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9C3</accession>
    <name>A0A914Z9C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9C3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8413.t1">
        <property type="protein sequence ID" value="PSU_v2.g8413.t1"/>
        <property type="gene ID" value="PSU_v2.g8413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000732">
        <property type="entry name" value="Small Glutamine-rich Tetratrico repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8413.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19154" checksum="189A8CD3B7A9F0D4" modified="2023-02-22" version="1">MLHYFLGEEEFPAPSAEDIQRANALKEEGNECVKASKFNDAIEKYNQAIKLNRDPVYFCNRAAAYCRLEQYDLAIQDCRTALALDENYAKAYGRMGLALSCQNRYDAAIESYKKALELDPNNESYKSNLAIAEEKVREAGQRFQSNPGANPFGGLGGLLGAGGGAPGAAGMPDLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB48</accession>
    <name>A0A914ZB48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB48"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9141.t1">
        <property type="protein sequence ID" value="PSU_v2.g9141.t1"/>
        <property type="gene ID" value="PSU_v2.g9141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9141.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36996" checksum="13FA10554C3AADA4" modified="2023-02-22" version="1">MTKEAQRYRRDLAGYNKEISAEQEERKRLENALTEAQQKLRDKEYTENSVERLKADLENALKRERNAKNALIEKEQEILNLKRSLDSERILNRDRNDYIQKETLERQKIKENENEIKRLKEQMQLYKNQLERVLTEKENELRDQKQRLQDELDQIREAYETQMLEEERYSQRKMDDLKNKIEYLQESRQKYSSILKDHLEALNKDKNKITSSLRSRIAQSYQLLNNQLHADGLKTFAAFQASTYQQMDEGDSAFSETTTTSYMIEQNEAFSRQPSGQQQQQHRHPDLIHPTSQSKYYNVKGQLRLSPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB93</accession>
    <name>A0A914ZB93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB93"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9577.t1">
        <property type="protein sequence ID" value="PSU_v2.g9577.t1"/>
        <property type="gene ID" value="PSU_v2.g9577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9577.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33855" checksum="6ECF94C7B62FDDC3" modified="2023-02-22" version="1">MIYFLEHILDNETVNAPNNGLEGGCAASYCIFRAGYDVEEALKECTCCIIPKHYHKMCTGQQGNKRSIKCRDIREYLRNNVLYNYLQSERGKEQESYRKFVLSVTEAESKLKKAVVSKSNIMGPNIKQYYKILDKMGVFRNAWFGNFNGNQARILMTQTEKFNELDAAKDHPRIQHLLTALQKLGSLQNYTAAKYLTEQQIEDLKVGVADYFQHMATNLGDTNVTPKAHFLNHLEEFAAMFKTIGLLSEQAIEAIHALVNSLYPRASFMKKADRDGWIMKYIWRLGSLHDMTKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBM5</accession>
    <name>A0A914ZBM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7650.t1">
        <property type="protein sequence ID" value="PSU_v2.g7650.t1"/>
        <property type="gene ID" value="PSU_v2.g7650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7650.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="24125" checksum="7B4EB0C6ECB18BAB" modified="2023-02-22" version="1">MATTGRFARVQQWLQFHRQWHVVDASNQDVYKLGKKVADHLSGRYKPIWHPESDVGDYCVVYNCKDVAMKGFDWKHVHYHFNKEYPRSKNEIPAYQIHEFDPCRIMFMATYSELGNNLIRRQHILRLHLFTDDNIPEIIRANIGRQMELVQEIPKKSTDFSEKDKTKFPQLFTRNENHLLDWEVPIKAPEYIRDPRIKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCW7</accession>
    <name>A0A914ZCW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCW7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9790.t1">
        <property type="protein sequence ID" value="PSU_v2.g9790.t1"/>
        <property type="gene ID" value="PSU_v2.g9790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9790.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15717" checksum="944AAFF1A50F84E6" modified="2023-02-22" version="1">MVCMIKKESDIPENIVNDLIRIRRSTNNSMIEEFLDQELGAIVNLTILNNNFNSNNNNSNNNNETTATLTKCQLARLRKRAIEFESNPQLLEALNERLENEAAKNANNNNNNNGGEDGLKVEVKTCHAGASLVEWSGTEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFP7</accession>
    <name>A0A914ZFP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZFP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9099.t1">
        <property type="protein sequence ID" value="PSU_v2.g9099.t1"/>
        <property type="gene ID" value="PSU_v2.g9099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000447">
        <property type="entry name" value="helicase SKI2W isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="116"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="382"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9099.t1"/>
        </source>
    </evidence>
    <sequence length="1057" mass="120938" checksum="98FF5FDD4E21D5A9" modified="2023-02-22" version="1">MMNYITAIPESKTETNVTHHDALDDLEDISSFKKKKKPKKIEEIIPVEVLAQAQALQSAEEKINTTGTTKFKKGIDGFEYAEMLDVKSNVSEYHKMKNNLARTYPFELDPFQQQAIVAMENGHSVFVAAHTSAGKTVLAEYAIALSRKHRSRVVYTSPIKALSNQKFRDFRNQFEDVGLVTGDIQLNSDASCLIMTTEILKSMLYNGRVSPDELEWVIFDEVHYINDTERGHVWEEVLIMLPQQVNIVMLSATVPNCLEFADWVGRIKNRKIYVVQTLYRPVPLAHHLYSGKDKKSQNNLFEIMGRDGEFNMNAYNKAKAAQIAQWSQKKGGPIQNTNKTFFSKAVDRCHYQTLIAFLKEKSLLPAVSFIFSRNRCNQYAEMLYQIDLTTNDEKAAVRKLFTKYLDSFKGSDRNLPQVLQMQQLCYRGFAIHHSGILPILKELVEILFQLGYVKFLFATETFAMGVNMPARTVVFDSIDKFDGTTRRPLNCTEYIQMAGRAGRRGIDDTGVVIIMSKGSEPHDHSTLLSMLRGKAISLESKFRITYNMLLNIIRAEQLNIEDMLQRSYVERVSLRLIESRKEKIAEVMETLEALPALTCSDCTQVEYGASIDDYYSSLMTYIEQRGNLMNQLITSYGAGNKIIPGRYLLISYPQKNIACMLVSVQSVTNNKDAKELDVVTLEMSPVENFKYDSLTEEEKKKEKYELLFEHSIKYGLETLIDNGQSSDKLELIRNVPFENIIAICKAKAKNYNSKEVSEYFVQKSSVNNRRQSPSRFISNLMTEMDMVMKANIQRQDDNFLYKIGEDLTSKELKINAEICEFVQLRKNLLDDNKYLCRQCLDFDTHIHMVHERNLLEIEYDNLKYQTSFNALALTDDYRRVAAQINEDTLLLTEMIFENKLQNRGCSEIAALLCPLTAQHHSAKEKQNERDCKILTTIANIDVINTLKEEMANMANKIDGIERTCRVVNARRDPPTFGLMEAVYQWAEGMSFEQITHLTDAHEGIIVRCIQRLDEVLKDIRNAGRIIGDNALVQKMVDTSAAIRRDIVFAASLYTADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQ82</accession>
    <name>A0A914XQ82_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g1018.t1">
        <property type="protein sequence ID" value="PSU_v2.g1018.t1"/>
        <property type="gene ID" value="PSU_v2.g1018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="266"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="266"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1018.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39666" checksum="B679BCDDD871CB75" modified="2023-02-22" version="1">MXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCNYSRGFASATLITQRKTKLPKPTPNAYALFIKSQKGTSPFPKFVDIAKYWKTTSDEEKKKFTEEAVKLREDAIAQFEKLPEKEQQKQFDEVAKSRADRKFRTKLPKPTPNSFALFIKSQKGISPFPKLVDIAKKWKTTSDEEKKKFKDEAVKLREDTIAQFEKLTEEEQQEQFDEVNRRRACRKFLTETKCPKRPLNAFILYYQEKYPATSKQDIIESAKKAGEAFKNLSEDEKKPYFDKSKQQFEAYKSDYEKWYKVHGEDYKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQV8</accession>
    <name>A0A914XQV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XQV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10386.t1">
        <property type="protein sequence ID" value="PSU_v2.g10386.t1"/>
        <property type="gene ID" value="PSU_v2.g10386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10386.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30374" checksum="4613DC353B8FA627" modified="2023-02-22" version="1">MVYLHSVGIVHRDLKPANLFINGDCLLKIGDFGMARSVAQCKPGTSHNPLTQYVMTRWYRAPELLFTFPTYDTKIDIWSAGCIFAELIMRRQIFPAKDSPSQIKMIVYYLGTPTEDVMNLVRESEIKKVIYDCGDKKGLPWSTILPKASPKALDLVSKMMKVKPWERCSAQEALENIYMDPYHDAGNEPIGHAQIQIDTDLIEQYKTTQLHEALAAEIGHFQAIRCRYEGEFIAPTSLSSSSSSFPPSSASSSSVSSFSSPIFSTTGFLPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSQ6</accession>
    <name>A0A914XSQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type VII secretion system protein EssD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10300.t1">
        <property type="protein sequence ID" value="PSU_v2.g10300.t1"/>
        <property type="gene ID" value="PSU_v2.g10300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044927">
        <property type="entry name" value="Endonuclea_NS_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13930">
        <property type="entry name" value="Endonuclea_NS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037755144" evidence="2">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Type VII secretion system protein EssD-like" evidence="3">
        <location>
            <begin position="105"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10300.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29610" checksum="821D4951EBC25BB6" modified="2023-02-22" version="1">MFKRFLLIFLLPNVYCQNPCSVLNQTYIKIIETEIKYEGEKEERRCPLNDIDNDLLFHQVCYELDDDDYDIIKYVHGTINSDSIGKGTDPVQRAKQFVRVNTPLCGQDDAGHIIPKVLGGKGGPSNIFPQNSNLNQRLWKQACDELLLHIRERPYSKTVDVQIVFKYKPGSNRPWIFLYKFIFLAENSAVERTVYGFFENQNYLDATLERCSHPTMANTIYNYAANMNNYFSKRSCQPQQNPSNEYGPRIPLNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUT8</accession>
    <name>A0A914XUT8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914XUT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10730.t1">
        <property type="protein sequence ID" value="PSU_v2.g10730.t1"/>
        <property type="gene ID" value="PSU_v2.g10730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="227"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10730.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41006" checksum="0B7F7A4362ED4959" modified="2023-02-22" version="1">MCSPALMSLWDAEGYLNFHQNDPLARVYYKKLRKIQEIYIPLIIDGNNVQCNSQTGSGKTAAYLIPLIKKCKDAVFDVKPFPSGPNTPFEIIICPTRSDISFGRNYGQMNVEVSVAVLSEHVHILVTTPGRFQYSNFKLVFRHLKFRVFDDATELFTTNFKDIDLKIYENDLNDNDTFRILCFSGSDGYDEVFQEIAKNCPRVTIQQIVAVNSNIVQTFVNLDYNQRMLHIMDLLKDKSHHKKGTKCIIFTNSIEESELFGMVLMNFEFSAAPFSSIRSQEIRDNTIKEFQGDRLDIIVTTDVCARGMDVKCVDLVINLSLPKSFNTYVHQVGRCGLIRAGKAISFVNLKIDAGLIREIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVB7</accession>
    <name>A0A914XVB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11881.t1">
        <property type="protein sequence ID" value="PSU_v2.g11881.t1"/>
        <property type="gene ID" value="PSU_v2.g11881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040035">
        <property type="entry name" value="TMEM180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN CONTAINING 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11881.t1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44741" checksum="3CC1210187663F7F" modified="2023-02-22" version="1">MIWNAINDPLFGYLQDVGGTWMKSRSKIFTWFGPILALSFLSLWFPWGNSTSPPWVEGLHLIVALFLYDAFFSCVGVAWGALFTESTRDHRRRVKALKYSQLAILCSVNVIVVAEKVSHSLDNFYVFQVFCVFLSVVSTCCFYITGKLSEQHLSASKDKLVADEETTPHSFHSIITLTKELLGSKDFQRIVFTNFIHSCRSTAHLNFASIATDLVIPQRILSKGSWQISAFFAVSTLLPQLLVIINEKVIVRHGAYRIIMFSFICSIISSFMYVLSWSPYVLIFFMIIDSITVHSMSPLFNIFLAEFTEDDAIRNSRRSTLSSVVFALNALIIKPANSIAPVVVVYFLNNSGYQTYQKDALRSPELSSCMIKILLLLHYYWEVFSYFCLKNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVG4</accession>
    <name>A0A914XVG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11222.t1">
        <property type="protein sequence ID" value="PSU_v2.g11222.t1"/>
        <property type="gene ID" value="PSU_v2.g11222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11222.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18086" checksum="FFB4902C7B9C4A22" modified="2023-02-22" version="1">MTEAEPIITEIVVTSEISKLAYEGNNMTSNFVELHRAWIVKGKYPEVLQEAWNVYNKKKKSYNTSPSEYSSITRHYVAMALSLGGIELELFELQSDEQLLSIFLQVTFALAVAETELKFEHRDLHWSNILITEDDERPFLQYRWKGTKYTVPTFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVP4</accession>
    <name>A0A914XVP4_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10599.t1">
        <property type="protein sequence ID" value="PSU_v2.g10599.t1"/>
        <property type="gene ID" value="PSU_v2.g10599"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10599.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33632" checksum="D217F6AEEA9E674E" modified="2023-02-22" version="1">MRDVFSIMDTVKKEEEIKAPKIPPGFEFAAAASETQKVDGNENDKIESKVTLMEYNDKDVGDGMQKVVESHIKIIAIEDYGNEDEEQKKLYSKINEVRRKSMDDKRAKENDKADNQMKDQQTSLPLIVITPPEEIKYESEEADDVGDSEESKQESFVIHQKEETDNSDDQIDETNASEVQDSIVEASETKVQEGHENQEEKIPAEIIQNNEKDNMRTEMDEFQDNKDPALAEVQSNEAVEIHGNPVESSLSFSCENAIADRYKDVAEKHEEQIENEGVRKEVFAHEEALLDSANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW36</accession>
    <name>A0A914XW36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10738.t1">
        <property type="protein sequence ID" value="PSU_v2.g10738.t1"/>
        <property type="gene ID" value="PSU_v2.g10738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10738.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19686" checksum="1D43A84A604B81A5" modified="2023-02-22" version="1">MSLPTAMTDINLMEGELSLYEDALDDSDEELQKLHYATAIQLEKVERQSRRRQILPIVATAPSISSAIHPPQSSSSEHSSIERLNGGEPVRSRRSTGTHKKRSHKSGTSSASNGGGGTPDEWKLVNHAFQEAASYPILFQLNQQLQTISVQLNELSCANALQLKTTYRLLRETVKVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWQ5</accession>
    <name>A0A914XWQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWQ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10964.t1">
        <property type="protein sequence ID" value="PSU_v2.g10964.t1"/>
        <property type="gene ID" value="PSU_v2.g10964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10964.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22360" checksum="EE8A47DE64401449" modified="2023-02-22" version="1">MSTNPIIPYAFHPKKKQNAKPTVVINNFCELLGLELPETRVSVSYCRCKHCPDMPTVKESVCCIDVQEATSKWAKNWKKFVDETDKCYSSHHVFQKIINDELDLDHFIQIDRMHLKQIANLTRSVYVDEYIAAEKNDMYRFACYRKTTYLVHDIMGIGKRVQLPACIVGAIRNKYPSKSETYKGYEEFFGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWZ3</accession>
    <name>A0A914XWZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10276.t1">
        <property type="protein sequence ID" value="PSU_v2.g10276.t1"/>
        <property type="gene ID" value="PSU_v2.g10276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF10">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10276.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25088" checksum="D5887655A7F0436B" modified="2023-02-22" version="1">MTNVSTSISQTTISVENVTSISPNSTKEKIVTSNQLFPDPLIPHNDEYLCCCGCFQIYCGTITIALFHYLFLCLSIIFEISSSGRYGFTFLGNIVIGCHSIFYIFIVVLFIGLEQKSTKMLLPYIIYGYILVALYIFAWIFLTIIVLLAQPSYIRRIIGKHDFSVSTIKIILFIKSTFIFLGLALIQVWCNFVVQKCRKYFRLLGESNSNNNSDDRDIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX30</accession>
    <name>A0A914XX30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11769.t1">
        <property type="protein sequence ID" value="PSU_v2.g11769.t1"/>
        <property type="gene ID" value="PSU_v2.g11769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037090594" evidence="1">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11769.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16021" checksum="94F24B0CE9CB61E9" modified="2023-02-22" version="1">MCFKNLMFIFPVIILLFVVISTEACPGLFGGGGGCGMMAPAFGGGGCGGGCGKRKKREVLEQQVKTEASNPCPQNEWKKIMETTITDNPSSSVFAIQGALHKQYEAKFFVTCSKVKNPTKHPAMFVTNGEGYCSYGNDNVWCEAIALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX78</accession>
    <name>A0A914XX78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10355.t1">
        <property type="protein sequence ID" value="PSU_v2.g10355.t1"/>
        <property type="gene ID" value="PSU_v2.g10355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10355.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16719" checksum="BC4DF1DF76052B64" modified="2023-02-22" version="1">MGSAMWTLSLIENEIQLSTFCDMFPENNIKRFQNGNCFVSYTLFYDTDMRFVFYSSPRIQMNKSEYFDSFCTPDEYMEKYDQALAERKVSKIVMHFELHLPLKYFLRPFDDPSSYLSKRCKGYPKDPKTDYKFAFLNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXE9</accession>
    <name>A0A914XXE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXE9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11199.t1">
        <property type="protein sequence ID" value="PSU_v2.g11199.t1"/>
        <property type="gene ID" value="PSU_v2.g11199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001927">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11199.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14234" checksum="952A3AD9C8C37F8D" modified="2023-02-22" version="1">MAIESLKSFEYSFKTDVWSFGITLYELFSLGEVPYSTIDNQQLLDFLDNGQRLPRPIHCPQEIYDIMKDCWQTNPLLRPSFSDICERLREILEAAAPDYGYLVAIPNTYHSTDSISAFRIDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZN1</accession>
    <name>A0A914XZN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endostatin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1342.t1">
        <property type="protein sequence ID" value="PSU_v2.g1342.t1"/>
        <property type="gene ID" value="PSU_v2.g1342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010515">
        <property type="entry name" value="Collagenase_NC10/endostatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045463">
        <property type="entry name" value="XV/XVIII_trimerization_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20010">
        <property type="entry name" value="Collagen_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06482">
        <property type="entry name" value="Endostatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collagen type XV/XVIII trimerization" evidence="3">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Collagenase NC10/endostatin" evidence="2">
        <location>
            <begin position="241"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1342.t1"/>
        </source>
    </evidence>
    <sequence length="427" mass="49056" checksum="30B23C62A6A80A8F" modified="2023-02-22" version="1">MTLIKTSEIPHDNRRDNQRSTALPEYDTRIHKHSSTKGEKGERGERGPPGPPGQPGTSYAPSSHHSSSSSSGSGGIVSVYQTSTELFASHRSTPIGQLAFSISAQELYIRVNNGWAKVKLEGFYPSVEQRAPVLNDDGDTASVDEYQPPPSPATQTYEPEIRTIAPPRRIEPPPRESSQDDQRLRHQQQLQLQQQQQRDQQLREQQQQREQQLREREREREHGYPYHQKPLSHANPQDKVLHLIALNAPVNGRMAGIRGADLQCYQHARKSGYRTTFRAFLSSNVQDLRDLVHYADNDTIVVNSRGEKLFDTWSHIFNPTIAPKINVPIYSFNQKNIFDDNQQWQDRYIWHGSDETGRRLEQNFCEFWRTNDQYAHGMASAVQSGRPLITDAEPISCHRHLIVLCVENMSKYNVDLRLGQRKQRYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y071</accession>
    <name>A0A914Y071_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y071"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12614.t1">
        <property type="protein sequence ID" value="PSU_v2.g12614.t1"/>
        <property type="gene ID" value="PSU_v2.g12614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12614.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13613" checksum="606989948F5C14B6" modified="2023-02-22" version="1">MASKTPQQTNGTSKPFNASLEQNIISISKIFDNITFDRIAELVNTDKNSVEKATAEMINNGRLKASLDQAHSLIHFQKSEDVVSIDQQFLCACQEANTIYNRIASTYPEWYAKKFPESVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0A5</accession>
    <name>A0A914Y0A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0A5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12650.t1">
        <property type="protein sequence ID" value="PSU_v2.g12650.t1"/>
        <property type="gene ID" value="PSU_v2.g12650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12650.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18906" checksum="D596DF6A9F8A2B25" modified="2023-02-22" version="1">MRFLSFSYEGGQVDGEERKKRRKEKRRKRKRDEEEARSASEGENKAPKKKRKTKKAVVEEEPVRKGKVKSRAYVSSSSSSDSDNDNGGTSQPQRNISADEEDVQPPAISDDSDLSDSSKKNDSDDESRRPVKRARIEDSDDNDDTGTPEAAAGSPAESEDQIKPPESDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0R8</accession>
    <name>A0A914Y0R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0R8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12810.t1">
        <property type="protein sequence ID" value="PSU_v2.g12810.t1"/>
        <property type="gene ID" value="PSU_v2.g12810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12810.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23305" checksum="63BA63538EA8B565" modified="2023-02-22" version="1">MDFPNQRNRTPFYDGDFERNKNYFSKQQKPRGQNQHSSRDNYNNNTYHGRARTPASFQYPQRSRTPNNNGFENHGQSQRSRDNYNNTYRGHARTPASFQYSQRSRTPNNNGFESHRPFRAPSRAPSRAPSRAPSRAPSREVSRSRSPIKRFRQSSKPRSRTPASKKSKTYRGQIELSSHLCGILSNFCSDLKDSGASVVPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1E6</accession>
    <name>A0A914Y1E6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1E6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13278.t1">
        <property type="protein sequence ID" value="PSU_v2.g13278.t1"/>
        <property type="gene ID" value="PSU_v2.g13278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051983">
        <property type="entry name" value="WSB_SOCS-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622:SF2">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13278.t1"/>
        </source>
    </evidence>
    <sequence length="479" mass="54170" checksum="E2561383D113B67C" modified="2023-02-22" version="1">MRDFASIDTDTYPVVKKSFKIHERPILGFNYYYDSKLDRNILVSVAQDSVKTWAATSFGDELDLMPLQEYAKQRCGSQACDILPDGKCIILVDTMNVLHVIQEDEKGDLDANIIDEGMMQILFCRFTPNKEQVFSINFNHGMQAFDFDGQNSIKKPLERKTSVSAVNFSASGKYLGLGFDFGLIEIRNGETWEICCRVEDAHKKKIRVVEFSHNDEHLLIGCDDKTLSLHAVFEITSSKVRNFSYHLGPILAACFDFSKESSQFCSASADQKVILWDINGTALHVFQKCFEEQVVTAVNFSRNGRFLFSGTANGQIIVHKMSTFFEEPPVQEDTEMVEEIQEMEEYIEEEETDFAKPDLELSEDENDIGQNLKDFDLSDSEEEEVVKDEEEQEEETPMSPTIETQNDDILAPESVKSETEEQENGNISGPASPKSIPEESQNPPESPLEEAQIPPESPPLSPVYERDHSDIPMSPPSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y251</accession>
    <name>A0A914Y251_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y251"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12861.t1">
        <property type="protein sequence ID" value="PSU_v2.g12861.t1"/>
        <property type="gene ID" value="PSU_v2.g12861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12861.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21609" checksum="CC0DA867AD295FF4" modified="2023-02-22" version="1">MESLGSLDHKNIIKLYGTTEISNKLYLLLEYASHGTLAEYFQRARQNFGPEITEQTAKNIFRQLVTGVHYLHSNKIAHRDLKPKNILLDSIGTVKIADFGLAKAVKFDVFLESLALMSAQIGYLGYCAPEVYNRTNNGYDGFKADMYSLGIVFRDVVKNSEATMTPECQSLFDKLTSKDPSTRPSASALLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2D6</accession>
    <name>A0A914Y2D6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y2D6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11961.t1">
        <property type="protein sequence ID" value="PSU_v2.g11961.t1"/>
        <property type="gene ID" value="PSU_v2.g11961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11961.t1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54886" checksum="29423DC854E3DD4C" modified="2023-02-22" version="1">MIEEEKSYIHGCSTVPLLFDTIGQRLRLAASKVPDREVAIFKKEGIRKTYKQLLNDSEKLALGLIHLGVEKGDRIGIWSPNHFEWIVTQFAAALAGYVLVNVNPMYKSEDLYYALDKVGIKALILPLRFKHSSYYDTLASIMPELQNYPEGRSDINSNTFPKLRHLIIFNDEGKAYRGAWRYSDVCEMATDDDRRKLAQVEMNVQPDDPANIQYTSGTTGKPKGATLTHHNIVNNAYFVGRRAGYHERRTIICIPNPLYHCFGCVMGILSAVIHFQTCVFPAPSFEPLAALQSIDEEKCTAVYGTPTMYIDMLTHEEYRNYDYSSIISGIVAGAPCPMTLCAKLVNELGMIDLQVCYGTTETSPVSFMSSREDAPEDRIRTVGHVMDNLEAVIVNKEGNVAPRGLKGELWIRGYSVMRGYWDNEEQTRAEITPDRWYHTGDIGVMHSDGSVSIVGRSKDLIVRGGENIYPTEVEQFLFRHPDISDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2P0</accession>
    <name>A0A914Y2P0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IRG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2P0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13715.t1">
        <property type="protein sequence ID" value="PSU_v2.g13715.t1"/>
        <property type="gene ID" value="PSU_v2.g13715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143:SF1">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13715.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18344" checksum="0E8B369C3CE5CA22" modified="2023-02-22" version="1">MPNVRFYDVPGSGAMSHKAANYYEDKALCGFDCLVILVQQTLAEEEIKFALAALEYNQKVVFVRSKCDIDFHLKDESGKNLRSIPSPEEIREHINELRYGFNRELENHAPQLSAIKCFFISSKSMRAIVRGEPSDMSFEEAEFLDYLYKQSKNARGISTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2T1</accession>
    <name>A0A914Y2T1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2T1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14485.t1">
        <property type="protein sequence ID" value="PSU_v2.g14485.t1"/>
        <property type="gene ID" value="PSU_v2.g14485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF101">
        <property type="entry name" value="SERINE PROTEASE F56F10.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14485.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16893" checksum="E84B06B2D7F143AA" modified="2023-02-22" version="1">MKHFAKYYLQQCGDLFGSDVITTDYITKKVAESTVNFGLSWNYNATNVVVPNGLYDPWSALGCKTERSAQHQFAPTTPGAAHCSDMYPVRAGEPTGLSNTRAVIKREVDYYLKSGLLDVSTPSAVTGSTTPSSSSKPSIIFSSLLFFVIALFVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3P6</accession>
    <name>A0A914Y3P6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">XRRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3P6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14065.t1">
        <property type="protein sequence ID" value="PSU_v2.g14065.t1"/>
        <property type="gene ID" value="PSU_v2.g14065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08777">
        <property type="entry name" value="RRM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="XRRM" evidence="3">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14065.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24970" checksum="1F8E3B3E280DEEA0" modified="2023-02-22" version="1">MSFNSLNSSDSQSAAKFLKGQVIHVSGLPTKNVNFGTLKDFFNNYAPDTYKVYEHGFLYYKQGSSEASLQFHTTEENAAVKALKKMNEDAKETDGKIRFRGHEIKCRVLEGEEEEKFWLDYAENMSDNAQNMSTYEYHREKPLSDFERRYREAIEMKIAENAMKKQKKKDQSGKKTDFTAKFFKGQVLHVSGLPTEMLHWILKIFQRICSCWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y476</accession>
    <name>A0A914Y476_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y476"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14242.t1">
        <property type="protein sequence ID" value="PSU_v2.g14242.t1"/>
        <property type="gene ID" value="PSU_v2.g14242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14242.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16549" checksum="D013516F57041A11" modified="2023-02-22" version="1">MGLDSVYVTTGMSIDKCDPETLIKNLWGYLVGYEEQPPPLYLQKPLLHILREALAILQSESTVIDLQGVVTIIGGVHGHGDSLTYHMSYSGLPPSATYIFLGNYVGEGFAPHECLFLLLALKVKFPKHIYLLKGCFEDPEVLKELIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y487</accession>
    <name>A0A914Y487_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y487"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12550.t1">
        <property type="protein sequence ID" value="PSU_v2.g12550.t1"/>
        <property type="gene ID" value="PSU_v2.g12550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12550.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27898" checksum="9DCCABCD529F0FC0" modified="2023-02-22" version="1">MFMPRASTINTSLGLFVFLFAISALIRLCRVLNGGWDQLADDMEQRGHRISLMNPPFCCVLWCLPTLAPTSENLRFFELAVSQAPAVKALVLVTEIVAIAEYREYSAFWLQLCDTVSLASLLALVFGFHALSRASGPTLSKFSYSTLFRLVDFGLLFFSAQEPLIFENIFVRFGAIGCTTTLNPHDQARFICNFVIILQLLLLSLLACMYLRPSRSALFDNHPRGYLSCSSTVAITEGDVSSDSSQSALIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4C8</accession>
    <name>A0A914Y4C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4C8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15052.t1">
        <property type="protein sequence ID" value="PSU_v2.g15052.t1"/>
        <property type="gene ID" value="PSU_v2.g15052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15052.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14502" checksum="7214A9F9195B5186" modified="2023-02-22" version="1">MVSRERERPTFALKVEKKLDSRRHSKLKMEIAILKAVNSIKQCGGEEKQEKAEKFLRHFTEIIDRAKKDRYFFLVMQLVGKSLADLKYERRERVLSLGTGLSVSHQCLEAVQCLHDVGYLHRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4J1</accession>
    <name>A0A914Y4J1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4J1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14361.t1">
        <property type="protein sequence ID" value="PSU_v2.g14361.t1"/>
        <property type="gene ID" value="PSU_v2.g14361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14361.t1"/>
        </source>
    </evidence>
    <sequence length="494" mass="56657" checksum="5FAE8C2A8F3AF45F" modified="2023-02-22" version="1">MTANFLSSQMTPQLTKIIDELLQQKDKRLDEISEWFEKRVAGVPRPILLRVLVQYYYFNQLRGPDKISERIILHFSVFNVSEFRKTFDNYNFTRRDQEINPSVAVLLKCYSDEYRKYDTNFASITSAEKQFIGRLLGYNYEQRRLLLFDETPEKLAKVRDDDPFNCYVVSLLKRSNTATFVRDVFMGLKATFPNGFSTSLQHSPAFLEQRIQQQQTIVNKVATSPAPSYSSVTMNERLEASSSAMSPTSSIRSVSQQAMIETAQTIFADFDNSAEPHFSARTDSGVHDCESINAESALDELFNGSIKSLRHDELESLKNFFEKDTNYGILKSYNITLERITECVIAFPKMMGSALAFMLAANDEKVYTYLNHMIHESFSAATMVAMVQMFVESFKRGLRLDPKFVDNTLTCCLDFLDSESAIKVTKSDDARIVRLVIYYIHIVVIYMPDVVSHRFGEIMNVIPNYSHIRTAPVTYNKILQHQRKYGTVSSSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6F3</accession>
    <name>A0A914Y6F3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6F3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15030.t1">
        <property type="protein sequence ID" value="PSU_v2.g15030.t1"/>
        <property type="gene ID" value="PSU_v2.g15030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15030.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13498" checksum="F96B89D8CB7D6747" modified="2023-02-22" version="1">MIAKLDDCVNTCQTSNTSAILNGILQCLKPAATNGVNCIEQMNRQFCTNDVNASINTNDVLENPGTGTVRKLMHEKMLKVVDQPNANALNILKSGLNSNQTEIQKCLMECVQKSSVILCLKEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y736</accession>
    <name>A0A914Y736_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y736"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14555.t1">
        <property type="protein sequence ID" value="PSU_v2.g14555.t1"/>
        <property type="gene ID" value="PSU_v2.g14555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14555.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15949" checksum="DE17DAA149F355F0" modified="2023-02-22" version="1">MITDTKKCLRFAPYCTVQRPSDEINVRVKACLRQPALFDIVEICEDFYEIIEACEPPFVQTDCLMINLKSGKVFSHQYPGLDLRIDKKICKKFRIGELITGTFYLQNPNDFRDNRYISGDAFKMDTEPLRTFTNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7P8</accession>
    <name>A0A914Y7P8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y7P8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1530.t1">
        <property type="protein sequence ID" value="PSU_v2.g1530.t1"/>
        <property type="gene ID" value="PSU_v2.g1530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1530.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33550" checksum="5E3B22926553FB77" modified="2023-02-22" version="1">MAAHFKTLTSKEVTIHNVWKENLNEEFVRIRQYIKEYPYIAFDTEFPGVVATPIGAFKTKEEFLYNQISCNVNILKLIQVGFCLVNSQGNLPPGGDIWQFNFQFSVNDDMYAVESVDLLKKSGIDFDKHQTHGIRVEDFGALLTTSGLVANDKVTWITFHSCFDFGYLIKSIVGPALPLTEKEYYNFHKILFPRSYDIKILMKCKNVQAAQLRGGLQDVANQLCVERIGNQHQAGSDSLLTAQTFFKLREKFFGGDTWERVAPELQGYMYGLGASKAASFFSIAGFSSAFFSSCIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7R2</accession>
    <name>A0A914Y7R2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7R2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13642.t1">
        <property type="protein sequence ID" value="PSU_v2.g13642.t1"/>
        <property type="gene ID" value="PSU_v2.g13642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037800979" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13642.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7629" checksum="405489A7D3011B03" modified="2023-02-22" version="1">MRPIIILLIVLVALASLPEPVSAGWYSGCNSACNGRARVGVARCCKSQGWGGGYCSGRRSFCITIINIGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8H9</accession>
    <name>A0A914Y8H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8H9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16502.t1">
        <property type="protein sequence ID" value="PSU_v2.g16502.t1"/>
        <property type="gene ID" value="PSU_v2.g16502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="57"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16502.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19431" checksum="11D9680E502DA450" modified="2023-02-22" version="1">MTFRHLQEITTDRNEIIAAIKDQSELVELSDDQESIRRRRDKPEGEHGKVLADYKRRSVFIGNFPRYTTFDEIKNDYLALYGNIPSFVMRRAKSNQSFRGSIFATFETEELAREFLENPAAEHFYGVALERQMQLDYEKNRPPRTSGSSLVSSVISSVISYDIPYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9N7</accession>
    <name>A0A914Y9N7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CC2D2A N-terminal C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9N7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15478.t1">
        <property type="protein sequence ID" value="PSU_v2.g15478.t1"/>
        <property type="gene ID" value="PSU_v2.g15478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028928">
        <property type="entry name" value="CC2D2AN-C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15625">
        <property type="entry name" value="CC2D2AN-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CC2D2A N-terminal C2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15478.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15804" checksum="8745B1BAB512B16D" modified="2023-02-22" version="1">MAKDFSVDFRKVYQLRIYEPPEKVMLLIRELQPGSGWVELSRVYIPFPDDQKELEEIDFGSDIVVEKTLKTLGCGHPDRKSQCLQGKIFCKLRWTQPNFEKVFKKSFFRKSDSEEDQEGEKEFELIPSEVRLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA85</accession>
    <name>A0A914YA85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAP-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA85"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14429.t1">
        <property type="protein sequence ID" value="PSU_v2.g14429.t1"/>
        <property type="gene ID" value="PSU_v2.g14429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF117">
        <property type="entry name" value="PAP-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAP-associated" evidence="4">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14429.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17625" checksum="8D3C8528398605FD" modified="2023-02-22" version="1">MLVNEHELEFDLNVNNTAGIHNTLLLAHYAKIDDRLPALARVLKRWGRRAEIIDSQSGYLNSYTIVLMIVHFLQCGVSPPILPNLNALRPDLFDGNLELWKLEESYDLDLGIKMETNTTPIGDLLIGFFRYYGFFCYQRDGVYIRMGCLGDKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAE6</accession>
    <name>A0A914YAE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16255.t1">
        <property type="protein sequence ID" value="PSU_v2.g16255.t1"/>
        <property type="gene ID" value="PSU_v2.g16255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16255.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15014" checksum="F508CFBB768C42E9" modified="2023-02-22" version="1">MIIPITDTNSRDFTTFLEFLHRDKLHLTMENAFELFKLAATYAVIDLQQICDEYLASKVEPSNVLFIADGCLPFGGTALKRCMNLINEKPEQIFALPDFLKISYFLMEFILKQNRINISEEKLFEFVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAI3</accession>
    <name>A0A914YAI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transketolase signature 1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAI3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14519.t1">
        <property type="protein sequence ID" value="PSU_v2.g14519.t1"/>
        <property type="gene ID" value="PSU_v2.g14519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47514">
        <property type="entry name" value="TRANSKETOLASE N-TERMINAL SECTION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47514:SF1">
        <property type="entry name" value="TRANSKETOLASE N-TERMINAL SECTION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase N-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14519.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26379" checksum="3466F1AB2748B075" modified="2023-02-22" version="1">MGEVQGQGYIGQALGMADILAVAYRHAMNYKADDPKWEGRDRFLLSHGHYAIALYAALIEAGVIPEQELETYGSDDSRLPMSGMATYTPGMEIATKNNPAFVYNSMSDGELDEGSTWEAAMSAAHHGLEQLICLVDINQQQADGPSGKVLGFEPLADKWAAFGWHVQRADGNDIAAVRQAFDTARHVATPKPRVILFDTRMGCGVPFLEQREKNHFIRVDTDEWQQALDILDANKPGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAZ5</accession>
    <name>A0A914YAZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17381.t1">
        <property type="protein sequence ID" value="PSU_v2.g17381.t1"/>
        <property type="gene ID" value="PSU_v2.g17381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17381.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10234" checksum="6DD57305A6902EE1" modified="2023-02-22" version="1">MEEMPGNNVVDGNNGATPGGDGSSSSSNSATLSWSKILKNSQNKNVMEGFFNKICTSYENVDSCLAECEARSNSGVNIRQTYAGLKFICKDIRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBK0</accession>
    <name>A0A914YBK0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914YBK0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16653.t1">
        <property type="protein sequence ID" value="PSU_v2.g16653.t1"/>
        <property type="gene ID" value="PSU_v2.g16653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="15"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="124"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="243"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16653.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="42672" checksum="EC40FEC7A65B54CA" modified="2023-02-22" version="1">MGITSAGDIKYGKTPFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTAKRSCCAMLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBR1</accession>
    <name>A0A914YBR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16859.t1">
        <property type="protein sequence ID" value="PSU_v2.g16859.t1"/>
        <property type="gene ID" value="PSU_v2.g16859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16859.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8939" checksum="F269744FFF87D675" modified="2023-02-22" version="1">MENIRVRVGHIGAQNAMPKAEAILEICRKELLNDGILNVDFDVEIISQMGCGESFEGVAVGADMYHKQNVKAFIGPYCNAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC87</accession>
    <name>A0A914YC87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YC87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17830.t1">
        <property type="protein sequence ID" value="PSU_v2.g17830.t1"/>
        <property type="gene ID" value="PSU_v2.g17830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43271">
        <property type="entry name" value="BLL2771 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43271:SF1">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YNFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17830.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="47179" checksum="EAA2969D5CD2A6F5" modified="2023-02-22" version="1">MDSRALGLAMGLYIGGNAIGGMSGRLLAGIIADHWGWRWGIGYRAVVAAAATVAAFPFTSRRPAPIAVALAHAVRRPGPAVAVRYLVRADGRVRHPLQLPGLPPAGAAVPSQPDRGRPDLQRLSGGHLQLGVDGPAGHALRPRPHPVDLVCVDRRRHRAIGTAVVEHDGAGYRTGDLWLLRWPLGGQQLGRQPCRCDARRSLGAVPVRLLPGFERARWCGRPGLCGVGLAGCVPVRRRADPDRRWHYADLGRRCGRGPTKVGHYRVGCTSPFGERFTQQPGEIADQRRHTLAVPRQLHFRMRTSIGQRDEARALHADVIAGRRQDRRTQAGGGQTDQGRGLTGLLHDARGEPGGRAQRDHVVMDARTGAAAERHERFLREVAQRQRALRREPAQGRVVGMHDQRQWIDEQAVRHQLWWQRALADDAHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCA3</accession>
    <name>A0A914YCA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UDP-N-acetylglucosamine transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16924.t1">
        <property type="protein sequence ID" value="PSU_v2.g16924.t1"/>
        <property type="gene ID" value="PSU_v2.g16924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000037">
        <property type="entry name" value="Nucleotide Sugar TransPorter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16924.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23141" checksum="5846771CFEAA0FF5" modified="2023-02-22" version="1">MAAAITPPPPTNNALKWVSLIVLIVQTTALVLTLRYSRTQVTEGKKYLSSTAVVVSEIIKFITSGIMVLYNNGMDFALSRKELQREVFDKPTETLKVSVPAILYVIQNNLLFFALSKLDAATYQVTYQLKILTTAFFFVTLLGRKLNSYKWVALILLTAGVALVQLPKDSGKAATEHDSSEKFMGLIAVLIACLSNIRIFMDAKSSACIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD57</accession>
    <name>A0A914YD57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipoprotein SmpA/OmlA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17229.t1">
        <property type="protein sequence ID" value="PSU_v2.g17229.t1"/>
        <property type="gene ID" value="PSU_v2.g17229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037873">
        <property type="entry name" value="BamE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007450">
        <property type="entry name" value="BamE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04355">
        <property type="entry name" value="BamE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Outer membrane protein assembly factor BamE" evidence="4">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17229.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13503" checksum="15E80ABF6A3CF388" modified="2023-02-22" version="1">MGLPIPRRHSAGELDHCRASGPPAIGDDTRTGSLPAGFAHLAGHFHADRWDYPYLNKPGYGKSEQRTFTVWFEGDTLVRWEGDEQPDRQPFERSDTGKKHTPPPADADQAAPTPSVSGNQPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDU3</accession>
    <name>A0A914YDU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDU3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16934.t1">
        <property type="protein sequence ID" value="PSU_v2.g16934.t1"/>
        <property type="gene ID" value="PSU_v2.g16934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037066869" evidence="1">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="2">
        <location>
            <begin position="71"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16934.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23778" checksum="555A655A23968061" modified="2023-02-22" version="1">MNAVFLVLLFFVEIDSRQIFTSVINEKSPTEILRDDSFVAGLSTAGSDEVKVSDEWRKNAIQKLWNERELMTRTPLIHLNIPSMPNIDLIFKNESASRTGSLKHRYAWALVFWALLEGHITQNTTVFEASSGNTATSEGYMLNLLGVNFVVVVSYSSDTLEKIKEDRIRLYTSEIIKTYIGKRIERAEEEAKKRNGFFMNQFANADRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE83</accession>
    <name>A0A914YE83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YE83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17746.t1">
        <property type="protein sequence ID" value="PSU_v2.g17746.t1"/>
        <property type="gene ID" value="PSU_v2.g17746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000046">
        <property type="entry name" value="Putative B-cell lymphoma/leukemia 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="313"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="525"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17746.t1"/>
        </source>
    </evidence>
    <sequence length="655" mass="70113" checksum="FBCC35E827E78367" modified="2023-02-22" version="1">MKSSMLIFSGQRNLPSTTTEVKDAAATVPLMTVSTCHLCKLKSSNVWELLQHVFVAHGLRVSEENIPGFEYPRSESPMIARPQPTSAFTTPITTRPHLTTSKSLGSSGKSAFSWNVFCSEKLKKIAKDIDPSLEMSNLLSPASPEELRRVSQASFDEQQQQLASAAAGLSEFINQASNNSLLSLPPSHQQHQQQQPQPSSNISFQPELLQAMQNYYMNPTTAAAALFSLTNTSTTSPMLGLANNPATTASAILANLAAGAVKNPATMLAAAVAASTTTPTTPASMSFEEVLQQHANATTPLFNNTAAPASIPAATSTPNLIPQSPANTLRRRGSPLTGRNSLTPNVGASVGSPIQVPSTPTSTAGPTQSKVPRLLQDSRRSCSALNIPLTGAKSRTNSVTAAEGENDDEDKFIVVDDHELAEPAARRDSKSKKDRCTYCLKVFTNRSNLIVHLRSHTGEKPYKCTLCAYACAQSSKLTRHMRTHGQNGKETYHCSICQMPFSVHSTLEKHMRKCVVVSQINGNGTGTGRYNSSNALPRKSDPSPLKTSNNGNSNSIPLADANSLLALSKTPVSAAISHSQTNQMVLNWLQALHVNANSTTSTTTNPNGTITTTTSTSNNNNNNTTNVEMVVSTKEEYIAVDDDDMEATEASELIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEW3</accession>
    <name>A0A914YEW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEW3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18.t1">
        <property type="protein sequence ID" value="PSU_v2.g18.t1"/>
        <property type="gene ID" value="PSU_v2.g18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9860" checksum="A81BB6BA1037AF90" modified="2023-02-22" version="1">MRDTAEKAVRDHYSGVIPNSGNECNEISLEMEDRYGGFWMVSIFDSDYDIAYTISRRSRSYGLFGIDDRIVLIARDGGKYRHFGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFV0</accession>
    <name>A0A914YFV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFV0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17637.t1">
        <property type="protein sequence ID" value="PSU_v2.g17637.t1"/>
        <property type="gene ID" value="PSU_v2.g17637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17637.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22922" checksum="E7C037613F476D2E" modified="2023-02-22" version="1">MSNDDLGFNHSREIMIKPKIVVRHCIYKFFYLDDRKRRNDGEEIATTHTPKKVCKSAVFLPPPPAASTTINVFPQEVINELKNKIDKRPNTVQPSSSIMEPPASCQKGLVQLMERNRKAPSYSTSSATSRSIFANRNSPSYSASTASRSTAASRYNIPSYRTSGTSNVSNFDSASTTSTTSSIFSRSFVPKERPKQKKPDEKCSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG99</accession>
    <name>A0A914YG99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16361.t1">
        <property type="protein sequence ID" value="PSU_v2.g16361.t1"/>
        <property type="gene ID" value="PSU_v2.g16361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16361.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33933" checksum="31654E1B99CFDA65" modified="2023-02-22" version="1">MIFPSSTPPESETSDQLIVSNDKEGWCRNKKYIETVPNGYRCTVCRKVYGRYNSVSYHVTIYHRNPPIRCGVEGCPFTTREARYIHFHKYYRHGIKLPESIDLASRKCPYCRHISKSPAMLEKHICRHVQDCLKNGKTYTCLKCNHESENQKLMYEHLREHQLHAVEEEIKASKRAAAILEDTNTSGNASPSRGVEAVAKIKCEYCSHESDNELQLQQHKIFNHTTQILEAAQQQPPNPLTLFAWQQFLLTNSNFQQGTVESTAAKNQIKPQNTTPLLSLLPRRDNPLTSSTDSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGZ9</accession>
    <name>A0A914YGZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19592.t1">
        <property type="protein sequence ID" value="PSU_v2.g19592.t1"/>
        <property type="gene ID" value="PSU_v2.g19592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19592.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15440" checksum="3C4EDA8DAD3D31C3" modified="2023-02-22" version="1">MKPRFTGAAAVARMEAKRIQAQLQESQPSSIPPVPTQPVVKFCNKIDETLYYLKEKVDKALMHHTACQTISLSLQEIHNVNIREIMKQCNVKTPIELYKLMGFNFDENDCFSASPQCSIMSDSSDFTFPTSSSSSNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIR6</accession>
    <name>A0A914YIR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g19404.t1">
        <property type="protein sequence ID" value="PSU_v2.g19404.t1"/>
        <property type="gene ID" value="PSU_v2.g19404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053295">
        <property type="entry name" value="Innate_immunity_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324:SF3">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324">
        <property type="entry name" value="PROTEIN IRG-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="426"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19404.t1"/>
        </source>
    </evidence>
    <sequence length="1369" mass="152906" checksum="B8062C448D6EF996" modified="2023-02-22" version="1">MPKHCFLVYTCTATVDIPLDPTAPKTFVLAFPNYNSLIGPLFSGLLDKKPIIKLLRDYYNSYNPDYFNNFVLAPYTVNDAGTTAPNVKLSTTYDDFQQTFIDAYGNTTMTEPSPGALDQGFVINSLVNFAQIAPYSEIFIITNKLYNTTGNTNTDIYKSLANKRIKLNFLIYDDGTFQGFNDITLLSNFYDFAARSGGNVIPCDDVKAIEHFFDNYQGLQISQNSISSFDGSKEFAGIQSAGEFNYQTGKSYYIAATIKYASDGSPTFPWVQLQGKISTIQLNATVIIGRFYAKFLIPTSTPTDKYTVNILSGDLAPVFFVNVLEINPDHFYVIGFASEPTFDIQYTYPSYSGTGSRVYIVANAPDHDYSDVTIRYPYNKEFYTGEADERTNCKYNLITSNYTWQCSIPNQLYYITFDTSDRTHTEMFPCVSNGGSDTGNCQNGGQPDGNGNCVCPPGFMGPNCGDPVCYNGGTIQIDNTCRCSDYYTGEHCENALFSCQKDIPFPRFTSLLETFVLVVDLNLAPLPSIKPEDIPSVFQQYILVSAYQANGQDEALVQVYNNAQYFFTALSNLKPNSYPKDSRFAIRRALQAVKSDRSLVVWLSGATVLCGVDDDNPQPDDELLNLIAKRRVELRAFTKTQESACHRMISSYGNGVPLTYRNLENVFKYVNLLVPPTISDPDKANNNLVVVDSYITDDCQNIDVMLAIEKTQALPQYTNLHIILSNLEPAVGSTLTEIVTDLYDLQLTTDFTLKPQTPNTFCGYIVEALHPSRVAYEVTPSDNFEAEGYGVFYLAETTNLNIYFENGIEDDNFNNFPEVFTANVEYTNFTYEHAPVIRRQCTYPWSIEIMCDGFSGALKTKLIIKDSEKNSHQRLLTTYCIKKMTCSSYGRKLLTDDKDDDYGISQKVWTCGCSPLWYGTDCSIPICLNGGTPNRETCLCPNNYYGSNCEYQLLSSLFNYRLILIIYDVTGNDDQLESKKELVTEFINMYSQNNTNYYAFTTNVAGGPKVNVTNSASLILDAINAAVVSNKSIDLGQAFDFFNGQNLQVSLFQINGMFYITDSSVDPEQDFTTLFELQTKGFYLYSAYYYNNTDPSIPRLSDLSGLGGTTGAWNIYDILSDFSKFLHGGDLSVVPTPPITTTARPIPCVYNEIMDFTFFFDPVVSSTNYFGIFIYMRQFLIDLSSDLKFATVSEPDGSRAAFGVVNQSSGNLLCLSSAETLKDGATNVPFIKLLGNNNVNLSDVLRQANALMGPNARDHRNVPKFAVIITDRPIIDNLNEIVASAQKIKNETKIHFVVIGLGTGDFKSTYGKFAEQGMLYTIPDALEATQNAFKNKFYKDVCQVSNNLGHGDTSYDCQISKKSWPNLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIT6</accession>
    <name>A0A914YIT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIT6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20247.t1">
        <property type="protein sequence ID" value="PSU_v2.g20247.t1"/>
        <property type="gene ID" value="PSU_v2.g20247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037459527" evidence="3">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20247.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27995" checksum="D6ECCD294D18F3EA" modified="2023-02-22" version="1">MLKLFLLISLPIGLVLAQERPKHFDTNYFELVPITDIPDSCDSAPAHGYGIVNGGLEKCSRYLAETGEENKEDNDYEEFKCKNLRVNGHVVDGKCECKDKWKGPLCNEFVGCPEGYTIRDRVCAPNSCHHDGTISVGSQKVECSCNAPWDGQWCERLACWRKAPKGHDRRWKNAGDHCECADGYDGDDCDIITKCKNGELRKNRCVCAEGWKGDLCDQKCKPNQTCAASGLFYGIFVVMAPVLGALIFRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK57</accession>
    <name>A0A914YK57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YK57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19912.t1">
        <property type="protein sequence ID" value="PSU_v2.g19912.t1"/>
        <property type="gene ID" value="PSU_v2.g19912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19912.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="35271" checksum="CEE6E26014C0F548" modified="2023-02-22" version="1">MSTQFQRGNTKPGFESPIPQSPTTSFGPHNFKRDQYRHSTSGYSTPGGASVYSSYSTSPNVGCLTSVRMSAMAKLSRFLRRLVHFRQMDFEFAAWQMWSLLTHPQLVYRKFVYRKRTKDQWARDDPAFLVLLAVALSLSSILFAVVLHLSFAGFIAFYFWAVFVDCVFVGLVIATLIWFISNRYLRRGEDQDVEWGYCFDVHLNAFFPMLILLHVILPLIFSSLVDYPNFISRLIGNAVWFIACVYYVYITFLGYTALPILRNTQIFLYPITFIFIFFVATVSAGWNISQTAMDFYHFRAMNANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK78</accession>
    <name>A0A914YK78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19931.t1">
        <property type="protein sequence ID" value="PSU_v2.g19931.t1"/>
        <property type="gene ID" value="PSU_v2.g19931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638:SF3">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638">
        <property type="entry name" value="OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19931.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11529" checksum="50F294D4087894D7" modified="2023-02-22" version="1">MGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAAMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLB5</accession>
    <name>A0A914YLB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polycystin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLB5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19688.t1">
        <property type="protein sequence ID" value="PSU_v2.g19688.t1"/>
        <property type="gene ID" value="PSU_v2.g19688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Polycystin" evidence="6">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19688.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13418" checksum="CFA2EC641D7A318A" modified="2023-02-22" version="1">MPFLEINRTAHFWIWAQTDLTNGILASFPDRPAYNLRGYFNDKGSRSVGIGHIRQIRSSKYKNCSNSLKKCIDFDSPEETTLAYSNGWKDVIDVSEAEYPYIYQSAKELDGNYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLC5</accession>
    <name>A0A914YLC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18120.t1">
        <property type="protein sequence ID" value="PSU_v2.g18120.t1"/>
        <property type="gene ID" value="PSU_v2.g18120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18120.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13067" checksum="A4714C069DB6A680" modified="2023-02-22" version="1">MTLFLLVKVFNSVAWVAEPLLIGEMSPTSTRNMMYGIIGFVGEIGSIIAPYFNRLKTYHEAAPAMAVALMSLIAGLLALCSPETKDKAMPEDINDFDPGEVYQWIFGTPKNQLIKRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLZ3</accession>
    <name>A0A914YLZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20591.t1">
        <property type="protein sequence ID" value="PSU_v2.g20591.t1"/>
        <property type="gene ID" value="PSU_v2.g20591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="159"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20591.t1"/>
        </source>
    </evidence>
    <sequence length="672" mass="72000" checksum="3D2ED8954D46DCE6" modified="2023-02-22" version="1">MSLVTDPSYDGAAYNQASKIVVGGNYAKTHPNDIGMIAHETFHSVQAYTHEVPSWITEGLANYVGNEFSESGQSLGKYISTDHYTQGYSAAAKFFAYLEQRFPGIVKSVDSIMRNGQHGEGQFWITLTGYPADQLWDAYVQANAAVCPSGNGVTTWNNAARDLALKLMNDKRSEIANGTFTMSNGAIAPAAKNMNKLTYSCEYEEAAQNYVNTCNDSNLLDYAFGSNIGLPWVVNSINDALTTSVPYYFSFIAANQNGNAMLMGGEGHFAYDNATTIGCGITTSPCWPNIKTALFCFVGPILPTSSPVYTVGSKCTSNSHCTRTTNPVCDIQSGLCIGTSTLTPTTTTTMTTVAPTTTTSQISPSMPGCSNGNGVTTWNNPARLYALQLMNDKRSEIANGTFKISNGVIAPAAKNMNKLSYSCEYETAAQSYVNTCNSSFLLGEAFGFSIGFPWLVNSINESLTIGVPYYFGFSVSNQNGNAMLTEGAAYFGYDNAKAIGCGFTTTPCSSGIKTDLFCIVGPILPASSPVYTIGSKCISNSQCTKPDYSICDVQSGLCLFSSQPATSTTPAPSPTQITLTFYDDLYFNGESKAWNGSGNACDNFLSDNFNDRVESVNTGNGCVMLYETRDCQGESVKLDPNCGLQQGCCPYHSSLAHDCKGFVNKASSHKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM98</accession>
    <name>A0A914YM98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM98"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21463.t1">
        <property type="protein sequence ID" value="PSU_v2.g21463.t1"/>
        <property type="gene ID" value="PSU_v2.g21463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21463.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17561" checksum="78FD636D63D43D2E" modified="2023-02-22" version="1">MILSMMEVRQAYSDKQKSKQKFANSSSAVTSVTAPSTAAASSNSTTVPPTSAGKLVPTTDIDHQYENLLKPKVHPPIATTDKIGAQLYDNPEAGDTVRKMVLLGDKIDIYYSNNVFCADLTAKTITAFLECQKAIVLLWNQLIQPLQLLSLTQMVHEKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMH4</accession>
    <name>A0A914YMH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMH4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21535.t1">
        <property type="protein sequence ID" value="PSU_v2.g21535.t1"/>
        <property type="gene ID" value="PSU_v2.g21535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000001">
        <property type="entry name" value="Malignant T-cell-amplified sequence 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="5">
        <location>
            <begin position="93"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21535.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20273" checksum="EEF6DE7A10D61ABF" modified="2023-02-22" version="1">MFKKFEKEDITGSQQLKSSVQKGIRSKLVEQFNGLDAHIEEILPKKENFRLIKGKDHLEFIAAPNGEMLFVKHRDYPYFPTLQLLHKYPFLLPHQQVDKGAIKFVLNGSNIMCPGLTSPGAKMTDGIEKGALVAIMAEGKQHALAIGCMTMSSDEIKKVNAGIGVDNVHYLNDGLWKLPPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMR4</accession>
    <name>A0A914YMR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Envelope protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20226.t1">
        <property type="protein sequence ID" value="PSU_v2.g20226.t1"/>
        <property type="gene ID" value="PSU_v2.g20226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20226.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32194" checksum="0FEC1ABB547E63B5" modified="2023-02-22" version="1">MEELTAAINNINEMISNDRYLTKTKQEFEFHVNKMERGLLKFMKLLGSRKSIKLSELPEPLLNFFEKVGYTENKLSEKLYLLRLKSCHRKSVVVEVIAAETNGVDAIKSFSPCTCEINSINQCKIKTQHALNNFIQFETYDELTTVATTYKVYTIQYPTKSVTKNVPVSGVFTVVINEDDFVKIGEYTISGKSLKPTYIENIIDDTFVVGEMAETKNITLNFTNLNSELNAFVSTWNFKLLIGIFGLLCLFTAFLFVGCCIYKKCTTKKSYNKLAFVVPQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNH6</accession>
    <name>A0A914YNH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNH6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20519.t1">
        <property type="protein sequence ID" value="PSU_v2.g20519.t1"/>
        <property type="gene ID" value="PSU_v2.g20519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20519.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18381" checksum="4896D97104B44F93" modified="2023-02-22" version="1">MAFPYQFAACAGLKVLIILLTIAVLILLDPRYVTAYISINYEIVLIYIIASLTLLYCIVSIITYFLLYRANGEEMSLTNCSLTEQNPGEIVFSGAGMIGWMIVCGIGGNIAQRTILETGQFFGWIGACAGINVALFIGVLAVFALNIVNDKILNNNHRKYQSPNNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP64</accession>
    <name>A0A914YP64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21213.t1">
        <property type="protein sequence ID" value="PSU_v2.g21213.t1"/>
        <property type="gene ID" value="PSU_v2.g21213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480:SF1">
        <property type="entry name" value="ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21213.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10183" checksum="470E494A0A879B34" modified="2023-02-22" version="1">MPQDKKYAGEPTRLEIGDGNMVREYVTINTGTVQDVGVTRVGNDNWIMAYTHIAHDCQIGNHTIIANSVQLGGHVHIGDWAILGGLTAVHQFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPE1</accession>
    <name>A0A914YPE1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Chaperonin 10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPE1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20860.t1">
        <property type="protein sequence ID" value="PSU_v2.g20860.t1"/>
        <property type="gene ID" value="PSU_v2.g20860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20860.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12020" checksum="BC6ECAE28F87FA24" modified="2023-02-22" version="1">MVFFTAIRNATSGALKGFVPLFDRVVIERAVAETKTKGGIMIPEKAQGKVLEGTVVAVGEGARNEKGDIIPTQLKAGDRVLLPEYGGFKVSVEEKEYHIFRETDIVGKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPI3</accession>
    <name>A0A914YPI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPI3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19270.t1">
        <property type="protein sequence ID" value="PSU_v2.g19270.t1"/>
        <property type="gene ID" value="PSU_v2.g19270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF7">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037092726" evidence="1">
        <location>
            <begin position="24"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="327"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="476"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19270.t1"/>
        </source>
    </evidence>
    <sequence length="559" mass="61677" checksum="9BA8F144C78D594A" modified="2023-02-22" version="1">MLLRSVSYQFLLIQFLFFATVLTSEIRPCQIGDPCNGCRLSKPGDKCLKDIRQPSLFCDLKTNQTDIHENAYLVCDLAKRQLNRKVCAANEHFSDGECKSGKNRYKRQGVAGSGRVGDFCSFNTDCLTGMFCSTGTCTCLSNFVAIQGYCYLKKNPGESGCQYAEQCSAVWPESRCEKSRCECPEDVNGIPYVMSKSRDGVVCILHSGEDGDPVPKCPLPEYDDDLLTMPVSQLRNAAMTDPDDQEVPMGEHVNPLQFCSSTATDYTNFVTNGGGACVYGQEPFNSGNGIYIADIYDCVTAPSSMSNVKAAMEGVYDIHPASDAFTCIQPKREADSGAAAPAGVRPRWWYNAVTGTCEQFMWDPWDETEMQSPNNFKTREHCESYCRDTCKRGSPQYLSGSQMNEDEPVSNCQTASSCANNFECTSVGSMQLCCPTVSNICSNGGGRPNDILRSTNFDPGQPMKRTYSLTYATSSRYYYDAEQGRCIAFTYHGALGNYNNFKSSAECELFCAKLQCNYGTPLKIGSNNQRCSSNSDCPSTHECQSDHNVCCPRPRKLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPI5</accession>
    <name>A0A914YPI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPI5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20912.t1">
        <property type="protein sequence ID" value="PSU_v2.g20912.t1"/>
        <property type="gene ID" value="PSU_v2.g20912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20912.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23074" checksum="20C56F589A6DA71B" modified="2023-02-22" version="1">MFFSRALNVAQEKYSQTEKEGLALVMAVKVFHRYLEGRRFTLLTDHRALLSIFGPKKQKPSYAVNRLHRWSLFLAAYNFDILYKKTTEFGQADALSRLIADTRQIKDQFEEEEEIDETSHAARVVQAINLLPVSADDIKVAYENDQFAQDIFKELQSSNPKDAGRFSNFFDLEFCNNSILVMLVFPEPKLLLDNIVIGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ93</accession>
    <name>A0A914YQ93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g1953.t1">
        <property type="protein sequence ID" value="PSU_v2.g1953.t1"/>
        <property type="gene ID" value="PSU_v2.g1953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03216">
        <property type="entry name" value="ABC_Carb_Monos_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000127">
        <property type="entry name" value="Ribose import ATP-binding protein RbsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050107">
        <property type="entry name" value="ABC_carbohydrate_import_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790">
        <property type="entry name" value="CARBOHYDRATE TRANSPORT ATP-BINDING PROTEIN MG119-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF1">
        <property type="entry name" value="XYLOSE IMPORT ATP-BINDING PROTEIN XYLG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1953.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34625" checksum="A38D87117C06836C" modified="2023-02-22" version="1">MKNITKTFGSVKAIDNVCLRLNAGEIVSLCGENGSGKSTLMKVLCGIYPHGSYEGEIIFAGEEIQASHIRDTERKGIAIIHQELALVKELTVLENIFLGNEITHNGIMDYDLMTLRCQKLLAQVSLSISPDTRVGDLGLGQQQLVEIAKALNKQVRLLILDEPTASLTEQETSVLLDIIRDLQQHGIACIYISHKLNEVKAISDTICVIRDGQHIGTRDAAGMSEDDIITMMVGRELTALYPNEPHTTGDEILRIEHLTAWHPVNRHIKRVNDVSFSLKRGEILGIAGLVGAGRTETIQCLFGVWPGQWEGKFX</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQL4</accession>
    <name>A0A914YQL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">cAMP-regulated phosphoprotein 19</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2310.t1">
        <property type="protein sequence ID" value="PSU_v2.g2310.t1"/>
        <property type="gene ID" value="PSU_v2.g2310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="3 4" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2310.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20963" checksum="A02DF1EC5EB03704" modified="2023-02-22" version="1">MLDDYKTENIETNSTDVEKQQEMILINKLQAQGKNPPKSQSTFLQKKLQQRKFFDSGDYAMNQDKEKKHQRPSAIPAALGGGKKAPLPESAKQPTSGTISSHSHSTTSSSSSSTTPAAPPSSSVTPPTVTPATTITTSPTSDDDEEEHLQIPRPDTVPQRKASILHPSAHSKLSPQPLIHHEHTDELLSSPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRX1</accession>
    <name>A0A914YRX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20144.t1">
        <property type="protein sequence ID" value="PSU_v2.g20144.t1"/>
        <property type="gene ID" value="PSU_v2.g20144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20144.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12268" checksum="60CBA220BF549285" modified="2023-02-22" version="1">MYDMHIFRPDKSVPQSVLSPFRLLKNVRHSARPTIVHCSAGIGRTGSVVALELCYQQLLSENKLSVLESVKALRSQRMHAVQTELQYLYLYKCLLTFSQKSRTNTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU73</accession>
    <name>A0A914YU73_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914YU73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21014.t1">
        <property type="protein sequence ID" value="PSU_v2.g21014.t1"/>
        <property type="gene ID" value="PSU_v2.g21014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="88"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21014.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40072" checksum="467157396368192A" modified="2023-02-22" version="1">MSTRQLRKRNASLQNGNTPNKRNLNGNKAAKLEPDVNTLTDRRLALCEPAPYSDEQAAIEERNKVDYSKKITLEMAKNNEGGRPVRVYADGIYDLFHYGHANQLKQAKKAFPNVYLIVGVCGDDDTHRLKGRTVTDEEERYESVRHCRYVDEVYKCSPWYVTVDFLKELKVDFIAHDAIPYVAPGEEDLYEKFRREDMFVETQRTEGVSTSDVVCRIIKDYDQYVRRNLQRGYSAKDLNVGFFSEKLYQVQNQVDALKQKSVDFLRSWKNRSDDIVRGFIDTFHKDGRIDLQNVGYKLRQIVSRSPSPQLEEQDDADFVDEEEDNDEPKEKIAKRDNSDNTITLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUB9</accession>
    <name>A0A914YUB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3264.t1">
        <property type="protein sequence ID" value="PSU_v2.g3264.t1"/>
        <property type="gene ID" value="PSU_v2.g3264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="148"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="343"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3264.t1"/>
        </source>
    </evidence>
    <sequence length="450" mass="49544" checksum="14152C4AA42060FF" modified="2023-02-22" version="1">MADYGFAYDDHYGIKPPAATIKEEKTASHYLRLRGLPYSAKEADIKSFFDGLGVDEVQLTQNAEGRASGEAFVGFSSVADAENGLLRDKNKIGSRYIEVFRIGEVEYGRIRNRSNVGGYGGGYPVGYSNFSKPGGTPYGGGSGTAQANILRVRGLPYACKKEELIGFFTGLTVEEVVFGKEPGDVGRPTGEAYVKFQSVEDATSAMELNGQHLGKRYLEIFRSDLDQFEHFKRQMSSTAMPLNAIQTDWPPWYSDNYEWGGYGMPVSAPVSSRGRGGGYRGRGNLTGGPYRGYDAGPPRPSPYDYHGRMYGGSDPMGGYDNVYDPYGYSMPPQYSGAPQLNYNKIYLRGLPFRVTGQQISDFFAPLNCVEIKLGYLPDGRLSGDGFVEFGTPEEAHQAKQKDRQSINNRYIEIFDNAMKASPETIYKRIGGTGRFAPSAAPVHPPSAYQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUE2</accession>
    <name>A0A914YUE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUE2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4253.t1">
        <property type="protein sequence ID" value="PSU_v2.g4253.t1"/>
        <property type="gene ID" value="PSU_v2.g4253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4253.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8662" checksum="4A55EA9CDEF98114" modified="2023-02-22" version="1">MLEYPFALEYFVSEDRLKALKDSTENGRLKSDKFIAIKSTGVKYYLDIFPNGSDDEDRGETMIYLNLELGNEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUZ3</accession>
    <name>A0A914YUZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S24/S35 mitochondrial conserved domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3795.t1">
        <property type="protein sequence ID" value="PSU_v2.g3795.t1"/>
        <property type="gene ID" value="PSU_v2.g3795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="200"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3795.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="35786" checksum="624825BEDA92C317" modified="2023-02-22" version="1">MITSKASILFNSLPTNHAFVIRCESTLAERMKRAVGKGSYESEEDQRHRLEEQIDSQGEQFRELYIMPKRKLNAQIQLERMTGRAEQPKYSHPDIHDRLAVRRPRAEEMSPNQDWPSVWPAAATYRSSVVPLLIRMGSRKYPEKRAPFKRVGNLDLLKIPNFLHLTPEHIKRHCEAIKKFCSPFPKELISDPKLAEKLFPITVTYSDYLHQEISLRDPRARTNTIEVKLHSFGFNEHDNDKLRHLVGNRYNEETDTITIVTDRCHTHKQNRDYADFLLTALYYESKKLEPWEEQKLRDDNQVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVL1</accession>
    <name>A0A914YVL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4020.t1">
        <property type="protein sequence ID" value="PSU_v2.g4020.t1"/>
        <property type="gene ID" value="PSU_v2.g4020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4020.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="35469" checksum="BA9BA6C5B58A780E" modified="2023-02-22" version="1">MSKKLFDRFITFFVAVGVGTLSGSSVFHLLPQAFHLVHEFDANADHSYLWKSFFAVAGIYLFFIADKLIKVILEARKRCKDYELKRFSGNNSESGVNSLEAGHNRSRQSSDALVAYVKDGNAKDSLVNNTDCNEAKESLHQTHSICAHDHDMVYNNGDSVIATVAWMIIFGDGLHNFIDGVSIGASFSESILSGLSVSVAVMCEEFPHELGDVAILVSAGMTLRQALVYNVLSALTCYIGFFIGASFGNLNDEFASYIFAFSGGMFLYISIGCMMPEMKVAMENALEISVKKAIKVLICQICGIFLGLTIMVVMARYGGSISFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVT9</accession>
    <name>A0A914YVT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="WBParaSite" id="PSU_v2.g3767.t1">
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        <property type="gene ID" value="PSU_v2.g3767"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3767.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13437" checksum="1D3622FBE20A6BDB" modified="2023-02-22" version="1">MDRPIFNASDDEDDISETVVPAVTVAVSASDNEKENVGAAGADGGGGGAERKHTFHLSIPEEKNGVSDDFKRYHRNSSGGGNNSHRSSIASTIKTIKKIANYPEFVEGGDEYVFDKNQVSFFIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW79</accession>
    <name>A0A914YW79_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g4229"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4229.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26982" checksum="38AF87F178FA045A" modified="2023-02-22" version="1">MVKTKGSHDYLNHLLKRLVWYGNNSGIKFGNYDTINTCDHSHGTQLCITLQHQNMNKRLGIIFIDPKPTLPPEDSIFDSEKPFATQNIDVVDDAGDKDQNNEEPVTDAESSDDENVSKNVSEHQEAIFSRIRQIEEEAQVQCEKANGIEIGEDDIKKCVEFFCSQPDIPIQLKEDPVEMEKVIRHAITGGMVYHDRVYISQERRKEIWKEVDEYIGKYAKGMGFKYCKKHFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWD3</accession>
    <name>A0A914YWD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWD3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4280.t1">
        <property type="protein sequence ID" value="PSU_v2.g4280.t1"/>
        <property type="gene ID" value="PSU_v2.g4280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4280.t1"/>
        </source>
    </evidence>
    <sequence length="507" mass="56853" checksum="250B832F11AF0FBA" modified="2023-02-22" version="1">MTQLPGLPGFPTGPFVGVNPIPELPPIPESRLDGKYDNDGNFVPNSTPKPDKQILENRIHGVKIEPFKAAPNHFLHSQNDPPRSYANARGVEIVTVEPQQDHHQKAPRRSNLHSSGSSEAQDEDDEGVQPHRPKNARQWQTTATKLVNHQTAIEPPHFLTDKSIESIDKIIDEHGDKDHAGQSRHFQGSAEIVHPFGAGSTPKPPSNRREIFTTKLLLGALGFQADSSTPQPLHSRRNNHRLPAKVVKPQNRLVKPRRPAPPPPPHPQQHFFDSKSKQRTFQPEQKFVTKPPQIRSRIVPNRPQQLRQPTQKRPQPPPQPRQPLPVIIPILPPQPWNRDPQDAAFLHEVEEYDWRLHYKQQFLQQGTPTATQLRGYSRAQGEPQHPGHPHNSDYEDFIAIRNREYFTDNPPQRNLALPEAARPEASEVLIPFNNAQAQLSHTNFAQTGTRIASNSNNQGNGLPQIGGQPSNYFSPPVTQNPVFGGLFNLFNLNGQQGGGLFPGFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWM0</accession>
    <name>A0A914YWM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWM0"/>
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        <property type="protein sequence ID" value="PSU_v2.g4051.t1"/>
        <property type="gene ID" value="PSU_v2.g4051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111226" evidence="2">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4051.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26637" checksum="5097D8A81E9BE748" modified="2023-02-22" version="1">MMHLFLLLLISFFQHSFQKENCLSVDIVETEGRPTTPTWYSEIDLAAADPTSECPNNPCRSLDDFYDSYNLIEIKKHLLWLRRTRENSKEKTTEEASAEKFEHDSAALIEQNAVLPVLFPLKIPSTSMYGTSKTNLTVKESEHLTEKTAKCDDDTLIDWTASEAQKDYNQRAAELRKKLQPPKKPVTAIATTPQRSSAALELENTQLSSESTQTSLPPTTNLDKTQSDSIRKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXL4</accession>
    <name>A0A914YXL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5247.t1">
        <property type="protein sequence ID" value="PSU_v2.g5247.t1"/>
        <property type="gene ID" value="PSU_v2.g5247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5247.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7812" checksum="FFB20485ECF148AA" modified="2023-02-22" version="1">MKMRERRAGGRSNSIGANNMVPVLNENGAVELFPIMQDEQQPIVVIEEPVTEEEILRQQLGGDDDDRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXZ5</accession>
    <name>A0A914YXZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2951.t1">
        <property type="protein sequence ID" value="PSU_v2.g2951.t1"/>
        <property type="gene ID" value="PSU_v2.g2951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16468">
        <property type="entry name" value="RING-H2_RNF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042981">
        <property type="entry name" value="RNF11_RING-H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052804">
        <property type="entry name" value="UEC_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46359">
        <property type="entry name" value="GEO07743P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46359:SF2">
        <property type="entry name" value="GEO07743P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2951.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25343" checksum="CFFA69FCC7B3F5D6" modified="2023-02-22" version="1">MGNCLQILYHRTLNDDRTRLSAITNQEEENIMGASQSSSSSSSLSSSQSQQENNYDRYAAIRAAESSNIINQHLARNMIRVHQRSERPRATSAYVNELYVSSTLTGNDEAQMHNQLEEKRKARARGLLQQLRIDVYVEGQVEDECAICMIDFEAEEEIRRLPCNHVYHVKCIDDWLIRSFTCPSCMEPVDSALLAAFVAPKQGIDISTLACSPASWGSSPLQNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYS8</accession>
    <name>A0A914YYS8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine--tRNA ligase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitochondrial methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5263.t1">
        <property type="protein sequence ID" value="PSU_v2.g5263.t1"/>
        <property type="gene ID" value="PSU_v2.g5263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="9">
        <location>
            <begin position="53"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5263.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22280" checksum="D5C36FB072283011" modified="2023-02-22" version="1">MNKAVNLVNAELGKSLGNLLNRCSVPTLNPKQRYPSFDVEVMEHELKATGEKLVQDLNSLNEKVSKCYDDLLFYRGIEHIFDQVRNTNAFFEIHKPWKMKKGVDLSTILFLTYETVRVASLLLQPVVPEFADKALSRLGLSNEERTLETAKFGGGPSLQLYGRNLGENPGKLIDKLERDDETEAENNLPNEGNKRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ91</accession>
    <name>A0A914YZ91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ91"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5811.t1">
        <property type="protein sequence ID" value="PSU_v2.g5811.t1"/>
        <property type="gene ID" value="PSU_v2.g5811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5811.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10251" checksum="CB6B69DB9C1CFF8E" modified="2023-02-22" version="1">MAMVFIKQITASDGLPVEKVKNWTYSNGVPYFRFSPPLTQKIDLDENRDTFIMQMMWDTEVYMSECADELDELARYLQCLHSNTDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZA0</accession>
    <name>A0A914YZA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5423.t1">
        <property type="protein sequence ID" value="PSU_v2.g5423.t1"/>
        <property type="gene ID" value="PSU_v2.g5423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03215">
        <property type="entry name" value="ABC_Carb_Monos_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050107">
        <property type="entry name" value="ABC_carbohydrate_import_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790">
        <property type="entry name" value="CARBOHYDRATE TRANSPORT ATP-BINDING PROTEIN MG119-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF9">
        <property type="entry name" value="GALACTOFURANOSE TRANSPORTER ATP-BINDING PROTEIN YTFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="207"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5423.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="49358" checksum="869648DA5E87A0C7" modified="2023-02-22" version="1">MLTGSERPDSGDIWIGETRLEGDEATLTRRAAELGVRAVYQELSLVEGLTVAENLCLGQWPRRNGMIDYLQMAQDAQRCLQALGVDVSPEQLVSTLSPAQKQLVEIARVMKGEPRVVILDEPTSSLASAEVELVISAVKKMSALGVAVIYVSHRMEEIRRIASCATVMRDGQVAGDVMLENTSTHHIVSLMLGRDHVDIAPVAPQEIVDQAVLEVRALRHKPKLEDISFTLRRGEVLGIAGLLGAGRSELLKAIVGLEEYEQGEIVINGEKITRPDYGDMLKHGIGYTPENRKEAGIIPWLGVDENTVLTNRQKISANGVLQWSTIRRLTEEVMQRMTVKAASSETPIGTLSGGNQQKVVIGRWVYAASQILLLDEPTRGVDIEAKQQIYRIVRELAAEGKSVVFISSEVEELPLVCDRILLLQHGTFSQEFHAPVNVDELMSAILSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZS7</accession>
    <name>A0A914YZS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZS7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5129.t1">
        <property type="protein sequence ID" value="PSU_v2.g5129.t1"/>
        <property type="gene ID" value="PSU_v2.g5129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5129.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16936" checksum="198383F9E1C5C7F9" modified="2023-02-22" version="1">MKEELWLLKLPGSINQQLLKLDKLIYSSEHRYSTMSIIEPEKGQQWVVMSKVIFDENEDFEELSLIICPVSDIREIVFAGIRFIDYTNNKNLLRWQTKRDIEDEEQEVEEKRNFAEWLHQTLLEVSGDYRQQHTPPNLPKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z049</accession>
    <name>A0A914Z049_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z049"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6117.t1">
        <property type="protein sequence ID" value="PSU_v2.g6117.t1"/>
        <property type="gene ID" value="PSU_v2.g6117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF156">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6117.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="26839" checksum="084509DFBCBBAFC1" modified="2023-02-22" version="1">MASLRVPLTSTGGGGHPIGGAPPTYETFSSTSTSAATRITGEAEEKGGKEKKERGLTYAALRRPFSSPDENGLPLPPPHLKRLQRIIWRRRIFSIFPPMSQKFAERLRLAAPHVLLFIATMVYGIVGAVIIYRIEKPHEQSHIFSHSKAIIDAQNELFHVQIDRSSQNSTNITIQEAIDKLISVSFDAFAEGVKSNDLQLLRTNNTRTSRWSFHSALFFTATVLTSIGGGAYGTSERISFDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1I0</accession>
    <name>A0A914Z1I0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="5">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z1I0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5747.t1">
        <property type="protein sequence ID" value="PSU_v2.g5747.t1"/>
        <property type="gene ID" value="PSU_v2.g5747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504:SF1">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5747.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22248" checksum="AD9D6646E6AB7A9C" modified="2023-02-22" version="1">MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGGEENSLPGTLWYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z283</accession>
    <name>A0A914Z283_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ycf80</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z283"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6191.t1">
        <property type="protein sequence ID" value="PSU_v2.g6191.t1"/>
        <property type="gene ID" value="PSU_v2.g6191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6191.t1"/>
        </source>
    </evidence>
    <sequence length="567" mass="67147" checksum="5E1C588310A7B394" modified="2023-02-22" version="1">MLISQKFFDQCDPSYQDDITELERNLSSTEDNEQKQRFLDNFSSKYLMPKEYWELKLELSNYLWSISEEKCSSFVLKGIYHFYYDRKHEVYISDGFYRKILNLSIKKFSLMIPSKSRDYIKNALTYPHRHLEKFYQKYEENATSLPSPDLIKRHNEMKELYHRIKGAKNDDVEKWFSLLSEANDKQFIIHNIEYKIGGNLLDKKLWKIYIKYLKDENDIPELFHLYSKYCRFFLDDSIMKAEYEAEVKKYRNVAAVVPWINQFEFEKCESWGDVYGREEAANPNSAFILPNPPPMGFCGNFYANIISQDLSLPKPLIRYILDITNHALLRKFHKCCKYFFLRKPTPICYSIEVLPTKETKFKNEILLVNPNDTVSPPINNFYLTTSLLAHNFGENENQAYFISSIIPRIFQCDAKYIKIGYQKLTFNELKFFIGSGNVEVLELFDTKIANEKAENVPLEEVMKLVPNIRHFEMMPVKCTSKTAEILSNFNFNNKIKAFSLFEVFGEPINIQAFKEFCIKNMDKTFEMIISFQDGLFSEEFRTKFRESIKDSKNFSEKSINRIQIDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2B2</accession>
    <name>A0A914Z2B2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in several stages of intracellular trafficking.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2B2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6849.t1">
        <property type="protein sequence ID" value="PSU_v2.g6849.t1"/>
        <property type="gene ID" value="PSU_v2.g6849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090389">
        <property type="term" value="P:phagosome-lysosome fusion involved in apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06892">
        <property type="entry name" value="PX_SNX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000001">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000245">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014637">
        <property type="entry name" value="SNX5/SNX6/SNX32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF1">
        <property type="entry name" value="SORTING NEXIN 6, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036924">
        <property type="entry name" value="Snx5_Snx6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="76"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6849.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="51745" checksum="2A94F97D887265AD" modified="2023-02-22" version="1">MLAEYEGDEGDQKDPLSASSAATTTKPKVNGSNQKEEPELVEQSLDDDDDEQLNSKSANPGDTYRSNRTESIITDVNLEGILTVDISDALSERDKVKYTVHTKTNLPNFMKQEMSVVREHEEFIWLHNCLEDFEEYAGFIIPPAPPKPDFDASREKLQKLGEGEATMTKEEFQKMKQELEQEYLATFKKTVAMHEVFLCRLAAHPVFRNDNNFKVFLEYENELSVRGRNKKEVVGSFFKRFSQSADEILLSGQKDVDDFFEREKNYIVEYHTHIKDAAAKGDKVCKQRKVISDTYGKISQALEKCAQLEGLGGDKQFGRFVMKSADALEKLKKNEARVGTDEELKEADTLRYFTRETDAAKSLLYRRMRCLANYESANKNLERCRAKNKDIPKAETEQKEACEKFEAITELSKKELMELKKRRVDAFKKNLNDLVDLEIKHSKVRHYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2J3</accession>
    <name>A0A914Z2J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2J3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6930.t1">
        <property type="protein sequence ID" value="PSU_v2.g6930.t1"/>
        <property type="gene ID" value="PSU_v2.g6930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6930.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30033" checksum="4DCFEA7690686BCF" modified="2023-02-22" version="1">MKNGGCCSRLVDASFTQTIAIDKDNGIIDVINVRRAGQDIVTKNYYGFIGMADDGFRGARRFEGDGTELARAYATEAREFCDIILADIRKANESLQKINHPRDAVSDESVGRLRTVLTSHVNILLEGILSRERTLPELRIEAKEWEDYREQLKEELEHSNGVIEKLKEDSSGLGVNIKRRLETLGFDNVDELVDRYVILQDRIEVIEKNLVARSAGSNISRAPSTFSLLSERCPKAQTQAIKGGLSVGDKSGAKTPETRVQLPLPENWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2S4</accession>
    <name>A0A914Z2S4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2S4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6185.t1">
        <property type="protein sequence ID" value="PSU_v2.g6185.t1"/>
        <property type="gene ID" value="PSU_v2.g6185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000097">
        <property type="entry name" value="Bent, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="113"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="341"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6185.t1"/>
        </source>
    </evidence>
    <sequence length="606" mass="66002" checksum="5CCE471BEFD4374E" modified="2023-02-22" version="1">MPSAPRFTQRPSIQQTATGDLLMECHLEADPPPDVRWSHGGTPILASGRVSLTLTNLNGNLYKATLVIKEPSAGDGGAYKCTASNQLGESNANINLNFAGGDERAPTPSQKGPTFVGKPRIIPKEGGALILMECKVKSTSRPTAKWSKDGVPLGGGNFKDVFTDLGDNVYLCQLEIRKPSAGDAGQYRCNIKNEQGETNANLSLNFQQEEAPSEGRRSPSVGRKSPRPRTPSSRPETPSKRHREGTPSKRKSREGSPRKSVRSRTSTPTQDIQSSSTLQVESASSRKTATSKTEKMEITTTEKRKSDAGLPPAPKRGRSRSKSPAVGGKTAATDNEFKRTPVIMEPLKSKIKVASSGETVVLQCELQCHTSTKITWFKDNQIIESRSQYSSTFDGKVARLSISRMSKDKAGLYKCEATSDYGNTQTSAVVKFFESLDVSRKEETTKRKSVTIDENTVPEKQRAGADRTSRSSNVGLKAAASEPSPEEVKFQLFLPILFFLLPIFMTFKIQYKSVKNMEALNAEGESDNDTPIGDYIPMNDSFTNIPKIQFSPVNSVTSRSSSESDISSISSKSSKFSHIHNYVIASLPSGNAKRNILGGIIDFDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z317</accession>
    <name>A0A914Z317_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z317"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6743.t1">
        <property type="protein sequence ID" value="PSU_v2.g6743.t1"/>
        <property type="gene ID" value="PSU_v2.g6743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6743.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="45952" checksum="54FEF3092B91A9A7" modified="2023-02-22" version="1">MENLKESIKEFARINSCDKKDDANKITSFNLQEFLNSNISNILDLRHALPWLYHHQKDEVVLSELFGSIDSESQKLLQFSYETLEICYCQKWRNALQNDSCFTLALTVDDEFNGTFESLLSNWSQHYTQQLCDTCKYYIYANNYPKFGTSQKYFIIEINVTEKMNGLIFHKNFTSFLMFGILWMLVGAIELQDSSEPRNYITWKKNENKWKLCKNGRKWFKNEFPQNLKNFPILIFEKLSAVFIAPNNFIPVAEMPSTKNFDNSVISYVEDGSAIAVAYQDQHLQSNNYQLNTPELSVFQGNENMGDNQLYPQIMQPSSSQFHQHYYQPVFQGGQHHEVMQQQQQQQQQQQQQQDSINDHNNIQQSSDSRPNDQQSLPPIYTFIEGKTFQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3L3</accession>
    <name>A0A914Z3L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3L3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6484.t1">
        <property type="protein sequence ID" value="PSU_v2.g6484.t1"/>
        <property type="gene ID" value="PSU_v2.g6484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6484.t1"/>
        </source>
    </evidence>
    <sequence length="588" mass="67115" checksum="53CAB6096AA2C5B9" modified="2023-02-22" version="1">MAATNINYHLPLDIETRKIYRQWIPGMIVSNTFLVVSDFFIQARTAALLSFNFLQLYPSSSVVIVNADKEKDGICAQLKAVGILLKNIHQIKDDKQFKKQCSDGVAGVYFVTTKTILTMLAKDSLDKFDFKLMIVCGAEKADSTAGLAKVVPYSFNASKIFRILALSFALPKKISKVQSLISNLQIHRTLIKKTSDNDIGEILFNKETTFIDVKYETRELELLKLIISFCTENLVSVGIACVKNLKSLFFLDTEIWLKTIPENSEYRNLVEFTVVLIEGYKLLVQYGARALFLYFSSKSDIFDNVEEIVELKELKERLEVVNFGAFPNREKRDALQCHPKLEELYKIVNTDKRNVKFLIICSSPFGARAVTEYLVAARIKCIENVHDLYNLMADKPHLRGEEPFTAEEARKTFLQSTIPVMVSTDFVENLGMVMFEFSISMDYLTAGQRYARFGRKSFCLLTDEYETIPTSMRNYERKLSASDCNYSYNFNTVVSKLRIERPLKDYPIQYSVADLLISFNPEKDDAITSKVADGTITTATTTNSKITVESIEEGERYLKNLMGDFMIDNLDDAFYDTVDFLNEHVRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3T3</accession>
    <name>A0A914Z3T3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3T3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6550.t1">
        <property type="protein sequence ID" value="PSU_v2.g6550.t1"/>
        <property type="gene ID" value="PSU_v2.g6550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037080638" evidence="1">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6550.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19102" checksum="F43F9766E738C775" modified="2023-02-22" version="1">MSQLFVIFVIAVSAFVITFGCQSPTVLVPGERGPMGQEGYPGNSGTIDLVVSNRSIFTVTPAPKRKRREMESQILLTFEDIPAGDVEITANNLIKKVVNFAEKDSTVKHRIDEIFFETAEAKTDGYKYDITFLFQKESSKICKSYIEAVKKVNILMGKLQTLTMTCQGEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4K1</accession>
    <name>A0A914Z4K1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4K1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7282.t1">
        <property type="protein sequence ID" value="PSU_v2.g7282.t1"/>
        <property type="gene ID" value="PSU_v2.g7282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7282.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12862" checksum="15CB2785BD6EA963" modified="2023-02-22" version="1">MRIDVTLSCMMDLKRFPMDKQECPMVIQSYAYVENLVNLTWHIDPPTFPIGSNTEIKLNDMQITNTRFEKCSGPYPMFRGYGNWSCVRGFIVMKRLVMFHVIQTYIPTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5H9</accession>
    <name>A0A914Z5H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5H9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7150.t1">
        <property type="protein sequence ID" value="PSU_v2.g7150.t1"/>
        <property type="gene ID" value="PSU_v2.g7150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7150.t1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43841" checksum="E193B04989D3150C" modified="2023-02-22" version="1">MERSAVPLEFPFLPQNLKRIGYKNYLIGKWHLGYCKKEYLPTMRGFDYFYGYYNAQEGYFNHSSAFFDKNINSLVSGLDLFTEIDGISVPDRTKNGIYATHLYTAEAIRQLQKHDRKKPFFMFFSHQSVHAPLQVPPQYLIFCNPLLMSHWRQIYCGMLAAMDESFGLLIQYLKDSKFYENTIIIFSSDNGGDPKAGASNFPLKGQKSTIWEGGTRTTTFIHAPKSIKEFSFRKELFHVVDWHATILGMTGYPIDTYGDGINQWDLILTGIPKSQQRTKFVYNLDPPLFAIRHNNYKFIFESTSEYFLGNGKVRLYQISTDPYESKNLARKHPKLVKELLKKIFEYQKFARKHVRTVIDEAGNPKRFKGVYATGWCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6K7</accession>
    <name>A0A914Z6K7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6K7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8318.t1">
        <property type="protein sequence ID" value="PSU_v2.g8318.t1"/>
        <property type="gene ID" value="PSU_v2.g8318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8318.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21810" checksum="B48457EDD17E75CD" modified="2023-02-22" version="1">MISVNLEEGSIPDAMLKELIPQPEIIIKQEKIPKLKDVFELEASAASTGAVSTEPAIKPKCSFNRVSFSRSHTVYFLPNTKQRLHKKVVRSRHDAWRRYGALMVIHKRGGWSYTMNGKSKNFQKVDKDTPLPPAPVLPPILTEEEFHRRPLITIASSNSSKSKRQRQARTDNEKKESKGDTDTSVSEEEPPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6Q2</accession>
    <name>A0A914Z6Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6Q2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5928.t1">
        <property type="protein sequence ID" value="PSU_v2.g5928.t1"/>
        <property type="gene ID" value="PSU_v2.g5928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5928.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13329" checksum="AC3566933670E7D5" modified="2023-02-22" version="1">MPRKNIPKIIQKVYTEEGPLEEKNKRADEVAKDFSESEKKVVDAIKKFFGKRAEAIAKLDNETKSILKEIKELRQKQKTLFEKIQGDDKKAANFLLFGHAPQNLNSRSASGSSSSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6Y4</accession>
    <name>A0A914Z6Y4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6Y4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8454.t1">
        <property type="protein sequence ID" value="PSU_v2.g8454.t1"/>
        <property type="gene ID" value="PSU_v2.g8454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46274:SF6">
        <property type="entry name" value="TYR_PHOSPHATASE_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8454.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10734" checksum="E657D36BBDBC976E" modified="2023-02-22" version="1">MCSTSRDSLNKAVNFIDKIAKDGKSVYVHCKAGRTRSATVATCYLMSKYDYLPNVAFNIIKTARPQCLLRNNHWRSVNEFRRYLDSQKSPSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z959</accession>
    <name>A0A914Z959_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z959"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6782.t1">
        <property type="protein sequence ID" value="PSU_v2.g6782.t1"/>
        <property type="gene ID" value="PSU_v2.g6782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058814">
        <property type="entry name" value="ZIG1/7_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26428">
        <property type="entry name" value="Zwei_Ig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037264818" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="144"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6782.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22061" checksum="2E484B1B9509CC2E" modified="2023-02-22" version="1">MFLVVCILLLSLPVTLSKQTFAQGNLAVILNVSEGIVTPHHGIKGEFSQQSLWCQATEDGETALELHNASFQRTYSPHRHEAEIDNGNRAYFKFGKPSTRDIGKYKCDMVTADGKRAWGNLFVYMRPVFHTNGSIRLEVPDDDDKFTVTATSIKFSEGDTVTLTCPAVSYPTPDIEWFKDDRPVVCCAKELAPGGTPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB11</accession>
    <name>A0A914ZB11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9504.t1">
        <property type="protein sequence ID" value="PSU_v2.g9504.t1"/>
        <property type="gene ID" value="PSU_v2.g9504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042972">
        <property type="entry name" value="INSM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065">
        <property type="entry name" value="INSULINOMA-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065:SF4">
        <property type="entry name" value="LD18634P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9504.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="29675" checksum="1855E672861A7E58" modified="2023-02-22" version="1">MFGATTPFNAQTLATMFGFQQSQLSQLPPLPQQIIPQMPSPKLSPDTNFLASLIQEASKFQQQQQQSFLPSLQDLIIQNTFLNLLQAQISNNANAKIASSPPPPPPPAPVPQQFIPTQSTISSSPGSRSSPQNNESRKRPNSSISSSNNRKSTFDDSDSVAAPAPKRTKQMRKLASEDAETNSPVSGMHIKDMSEVSADDIAKAAELDETASFVVVSEETRRKLAEIPDVIKSTNCALCKVKFDDVIHLARHKCPRIVHEEYKCSECEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC62</accession>
    <name>A0A914ZC62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC62"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9319.t1">
        <property type="protein sequence ID" value="PSU_v2.g9319.t1"/>
        <property type="gene ID" value="PSU_v2.g9319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF4">
        <property type="entry name" value="BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="36"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9319.t1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47225" checksum="F8F741D79A73157F" modified="2023-02-22" version="1">MVSLIKSIFYTTPEIINVEGFVAPGYEGIKDVFEKNFINGWEPEGSSLAIYHKGKLVVDIWGGYADKECRRLWKSDTITITFSSTKAMAALCIALLIDRGLLSYEDKIVKFWPEFGKNGKDLITVQWILSHLSGLAYFDQEITEEDARDWKRMAKIIENESPKWEAGTAAGYHAITYGWLADQIVRRVDPKKRSLAQFFGDEIQNGADYHIGLDPSQSHRVARLKCPTVSQRISEFFTNPKAINYFQVLHDFATNGIFTKIEANPTWFKFFKHEITLNNPDLYTLEHPGVMGIGNGKSMAEIFHRAIFEKKLFKNPETLLKFASPYIDVKDKVVGMSNTRGQGLFHKQFFHKKSRTLCKSFGHCGFGGQMIKVDLENELCFGYVSNGLKCGLSDNIRTFASIQKAIYDCILIRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEW2</accession>
    <name>A0A914ZEW2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vinculin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZEW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8819.t1">
        <property type="protein sequence ID" value="PSU_v2.g8819.t1"/>
        <property type="gene ID" value="PSU_v2.g8819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017997">
        <property type="entry name" value="Vinculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46180">
        <property type="entry name" value="VINCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00806">
        <property type="entry name" value="VINCULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8819.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30603" checksum="2F029D663FE3D6A6" modified="2023-02-22" version="1">MYNWRGANDHLLSSVRSVGDAIAGLPSVNQHHQAPPPQHQTSPFQRRNYEDHHSAQAATPNHYQSAHSLVESVAAKAPSPPVVHHRMLIREEIPAPPRPPPPVEISPPPRPPPPPEVDEEEETRAFWERYPLPQASSQPILSAAHALHQEVRQWSSQENEIVAAAKRMAILMARLSQLVRGEGGTKKDLIDCAKAIADSSEEVTRLAVQLARQCTDVKMRTALLQVVERIPTIATQLKILSTVKATMLGSQVVIGPYGQPMDGKYILNFTSVKILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFT7</accession>
    <name>A0A914ZFT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serpentine receptor class gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZFT7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9140.t1">
        <property type="protein sequence ID" value="PSU_v2.g9140.t1"/>
        <property type="gene ID" value="PSU_v2.g9140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019420">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srbc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10316">
        <property type="entry name" value="7TM_GPCR_Srbc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9140.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17608" checksum="BBD390DE6B902BE1" modified="2023-02-22" version="1">MTLATSYVTFNVAKEMPNSRTTNCYTFGCMMVKHSLSSYVYVRYVVALLNSFVGTMLFLIFYNRSKVKDLRKYRFTKNNKLVLWTITAALVFDFMPHFAAFCSNTFFGINPNHYIGPYGIIATTLDVTLCAEMSRRVFSSYSYKRTGSIMASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XPU8</accession>
    <name>A0A914XPU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XPU8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10039.t1">
        <property type="protein sequence ID" value="PSU_v2.g10039.t1"/>
        <property type="gene ID" value="PSU_v2.g10039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10039.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17451" checksum="9FC79E2941A2B1F5" modified="2023-02-22" version="1">MLTTLFIDDRPFPERKSISKSVEVQPIPVDNLIVQKGLNNLKIYDIDAKRSEREFKYDRETSLRQAERSKYEKNAVEFQQKRIHQEIEYEIKSRDYFGTENIVVDFPKGSESFPELPPEAIQLVERAWQRHADEDETFISKLFAVLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQ64</accession>
    <name>A0A914XQ64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XQ64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10159.t1">
        <property type="protein sequence ID" value="PSU_v2.g10159.t1"/>
        <property type="gene ID" value="PSU_v2.g10159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10159.t1"/>
        </source>
    </evidence>
    <sequence length="912" mass="101617" checksum="12558A4A12A3B938" modified="2023-02-22" version="1">MSQNGSWSQNNYGASIEVSPIEVDLRSASDAPPRRSVQFSDKVQRFPESAPSSPKPTDTSPTSKNVNKTPLDIASESLKQDENVKKTDIPIQINSDNQPKNGNKPQIDSFIDVKMEKQNNPDLKIEFNSPLSNSSINSDQQQQQSDKQKQQQPQEKKDNFKPTPDVAVPSSLNQPPHVKNEDKNTNGDFNDRQFVTTVILNVEMVRTPKETDPEDDWDTDTVKLAFSTNATNYEPKINEQERKQTEENITDIQSGASSVTVSKDQPQENKPPRSPQFGESKEGWNQIDLSPLLKTAPSTDIANINASLNRASSINEEEESTEVNKNQKNEIENKTTEAAAIAETIAEAKDQSDVNSIEISTPKIENDKPATTEDSITTSKDSNQTNETHFGIIPSKAIEIPIQFHEDKPVTPVNIPLSEFGIPSESTTEIVIVFDNQQKSTDDMKDPDISLGTIPHKSIEIPIQREGQPSVPKSDIPLSDFGFPSEKSIEIAVNFLSDAETNVSENRIQKGIIEIPIQFEGQPAVSKIDIPLSQYGTPPLTHSEIPIIFAENGNNSSSNTDTKTNEARINVIEIPIHFEGQEAPTALQNYLPASETLTEIKIIFENQHESAKNAETNIVENKLGIEIPIQFEGLPTVAKVDVPLSQHGTPPLTTTEIPIIFSDAKEMQDAEDNSSEIAVIQFGFTAKKEDENATASSIKAEPSSDISEIKQDGALKKEESYDNDLSEIRKKKIFEIPIQFEGQPPIQSPNIPLSEYGTPAETREEIMIIFETPNEKSQKDDNKNEDRFGLLHYKIFEIPIQMGNDTTVQKIDIPLSEFGFPAEEVREIPIAFTEKDENQKKENESNKFGILQYKVFEIPVQHEGKPAVEKVDIPLSEFGTPSESAIEIMIIFEDEKQDDKEKEKIKRHSTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTH8</accession>
    <name>A0A914XTH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10570.t1">
        <property type="protein sequence ID" value="PSU_v2.g10570.t1"/>
        <property type="gene ID" value="PSU_v2.g10570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10570.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9317" checksum="E7068DC58D2610A8" modified="2023-02-22" version="1">MIFPNGGYGGGGYGGYGAGYGYEYGCVGYFTVLVIIFGMLICFCCAFSGLGYAYWKQKSKFEYANANPNGRSLSPQNTSFMPTYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV72</accession>
    <name>A0A914XV72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XV72"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10440.t1">
        <property type="protein sequence ID" value="PSU_v2.g10440.t1"/>
        <property type="gene ID" value="PSU_v2.g10440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10440.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16651" checksum="2DEA4F147FD87722" modified="2023-02-22" version="1">MEAFQKRNPFPLSKKDKRKQQIEQEQLLRDLISPDPLPIRTISRRNLNKVFHKIHEKLDPMFDMIDNIHDILPDVNIFKYEGCAPMVQCKEFYGDPFKDNVRIQPNMFEAIDERNTRDKIPLPPKYIKKPNNESNSIEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW00</accession>
    <name>A0A914XW00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW00"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11408.t1">
        <property type="protein sequence ID" value="PSU_v2.g11408.t1"/>
        <property type="gene ID" value="PSU_v2.g11408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="119"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11408.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45083" checksum="E40A1EB7B344AD17" modified="2023-02-22" version="1">MIHTQLRNQLLFGIVRAEVTKRKPEWWYCELLKACNTHPKSRVFATLLDNNLKDTLNEYELEVQQYCTPTIKKTSLEFVADEEAPQKPRPQNHFGKFPTYITGEVANHYSLRGYQHELVAKAKSGLSTVICAPTGSGKTLVALDIIVNHLRKQRHSGEVGRVVMFAPTIPLVNQQFEFLFSNMKPEFFVEKLSGVEKVNGKVGRADTILRAHVVVMTPQIFINMLLSPLKPNRLYLNDFTMFVFDECHHCDEHHPYNILMNHVRLSNYKPQIVGLTASVGDGAKGKSSGRLDPQGAIEHMLELCARLECNLITSVRSIDNLIEMNSYISQPVDQIFSIRPKEVDDFAHNIALLSDSIQNLFRKALEEAVRSNVGLNRVNLLYTVFSSFEKTFLECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWI2</accession>
    <name>A0A914XWI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11589.t1">
        <property type="protein sequence ID" value="PSU_v2.g11589.t1"/>
        <property type="gene ID" value="PSU_v2.g11589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004951">
        <property type="entry name" value="DUF268_CAE_spp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03269">
        <property type="entry name" value="DUF268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11589.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29740" checksum="48889E2291F97C6E" modified="2023-02-22" version="1">MRKFQIFLEWQNIAKNGLTLNPPKDLPNPDAFTLNNFSRSWYWFFNDTIQSDKGSERTWSKIYIDALLTIVSFNASHLKRPYVNESLAVYAATKMYNIKGQEGAIVGSQAPWAEVYCLANGAKHVTTIEYQKYIITHPQMDFLYAHDLPLISKNIEHSGLGRYGDPIDPIGDIREMNKIHCLLKNKGLLFLSFPVGIDTVVYNAHRIYGRIRLAMMFEGFKLLKIFYSQNIVSEEHMFQVFNNASLADHYLFVLEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWQ9</accession>
    <name>A0A914XWQ9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sex-determining region Y protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Testis-determining factor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRY family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWQ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11657.t1">
        <property type="protein sequence ID" value="PSU_v2.g11657.t1"/>
        <property type="gene ID" value="PSU_v2.g11657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22028">
        <property type="entry name" value="HMG-box_SoxA_SoxB_SoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="120"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="13">
        <location>
            <begin position="120"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11657.t1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45908" checksum="A2244204119B4A97" modified="2023-02-22" version="1">MMTMMESDLKQHQMMLDQYQMTYGFPPPQQLQQPQQQQQQQQQQQQQHQVHTPLRGGVPGDESLNGSADSPGSSSTGSHHGGGGVGNGVGSGGLGGGYGNSGLCAGGGKDNKKARNDDRVKRPMNAFMVWSRGQRRRMAQENPKLHNSEISRQLGQEWKLLGENEKRPFIDEAKRLRADHMRNHPDYKYRPRRKSKPSPAGKKPGQSGGMNSTAAAAVAQFDALKCSQVYPSMAPWNQAPVVSNAPNGYFDHYNQMYNGAYGNMMTYIQQQQQQQQQQQQQYPHQTNSPNLYHQQAAAAAAAQQHHSLLQQHNDSQQQQQQQQQQQQHYTQLGIKSELSDSSALNGSTTPTDATTIMEIANAVQAESAFRSIYEHKDHPLMTAMSMGYPYSAAAALDSHQLAAMGLSGLPPPSAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX40</accession>
    <name>A0A914XX40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX40"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10322.t1">
        <property type="protein sequence ID" value="PSU_v2.g10322.t1"/>
        <property type="gene ID" value="PSU_v2.g10322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10322.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11358" checksum="29642F2ECA37A5CB" modified="2023-02-22" version="1">MSFTDSETAGVTVHKRCQQLADMFQVPAMYSLDTYEINLPYDEFHKRVMSDANIRIKLQRIRRNSPVPVSITASGYWDHLNWHNIKINNFDFALPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXB0</accession>
    <name>A0A914XXB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11844.t1">
        <property type="protein sequence ID" value="PSU_v2.g11844.t1"/>
        <property type="gene ID" value="PSU_v2.g11844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11844.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26542" checksum="2A446AA1CE42F70B" modified="2023-02-22" version="1">MPPANSEKKKKKRVKKNKKKAKDEDFDEAAGIVQKLKQRYQNKKEESEIVKDPIISNGKIVHPTRYLSIIERGQRAQQSRLQAPDPPENLIETKWICALCQRYSCSDNLGDLFGPYYIELDNTKPVPTFLLADDVTISKTEKSSIACFLHGRCALWSENLYFFGGKFSKLDERLYKYWDTLCELCKERGASINYKENLHSHFYCLYILGYKFDNSNLRITANPNAEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYB7</accession>
    <name>A0A914XYB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10692.t1">
        <property type="protein sequence ID" value="PSU_v2.g10692.t1"/>
        <property type="gene ID" value="PSU_v2.g10692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10692.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21224" checksum="3B838431B47287EF" modified="2023-02-22" version="1">MKRDDQGNAIPALIPFIETWKVLEKYYNDGKLKAIGISNFNEKQIQELYDQATVKPQNLQVECHILFPQKELFEFCKKLNITFTAYAPIGSPGRKAIQKGESFVDESPMEHPLTKKLAEKYKKSPAQILIRQLMQRGMSVIPKSTNVNRVKENFDVLDFKFTDEEMAEFDAIKQNTRLFLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZC3</accession>
    <name>A0A914XZC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12309.t1">
        <property type="protein sequence ID" value="PSU_v2.g12309.t1"/>
        <property type="gene ID" value="PSU_v2.g12309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_6"/>
    </dbReference>
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        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="2">
        <location>
            <begin position="225"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12309.t1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58872" checksum="2BFDCC4E762461FB" modified="2023-02-22" version="1">MPEEYRIYKAAIEKWDHLHIQLLSLKYYTDIVKLNFYEELTKLFEMFKEIQIGFDAYLQKRKLNSPRLHFLSNNELLEMLSKGRDPKQVEPYFSKLFASISKPEFNNRGEIIAIFATNNERLELHRSKQKLFKINLNLNNLNRNAFDIELQAYLAECIKFLPSNEQQLLLLQNIFVDLIEAQNIIAHLIQKGSTSIEDISWTSQFRHYWSNDNFFVRLFNVSILYGYEYLALTKPFVKTDKVKNLHIQLALFQYQNFACLLQGPAATGKSETIKEFSKTLAQNSIEQLESLIIGTFLAGTILCLDEFNRLSSATMSTTINHILGIYQAKHSHNLFYNMHGLELSVNPLSAFFLSQNPNYVGRSALPSNTSSVAKIIDVPTADFEAIAEEYFLLASFNCSHQLQSVFSQCSAIVSPMRHYDFSLRTLLANVKNAIWLQNENSFLSEMGVTVKAAQNLLSSMFTVVDSKIFSKILLLSKSKPMITDSETAYKTALQQICETLNLATTPAFINACYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y156</accession>
    <name>A0A914Y156_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y156"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13937.t1">
        <property type="protein sequence ID" value="PSU_v2.g13937.t1"/>
        <property type="gene ID" value="PSU_v2.g13937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13937.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11344" checksum="DDA009FEFD31175C" modified="2023-02-22" version="1">MKAEIMWIIIGVILFFAVVIILGCSGFWGCRYWKQKNSAAKTDKKTKQNVLEKNIAETSVKQDKATEEMVEEKAKTIKDATEENKQSVPAKPKKAKHENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y187</accession>
    <name>A0A914Y187_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y187"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13215.t1">
        <property type="protein sequence ID" value="PSU_v2.g13215.t1"/>
        <property type="gene ID" value="PSU_v2.g13215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13215.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="34776" checksum="0178D20D50B27F1B" modified="2023-02-22" version="1">MQFKSSQRLLNPAKRHLNDDEQNVPIFPLLEANRLPSNTGQHILQRPLQNIKSGVTPNKYYDIVPRPSGRQDMRTREWRAYMNGQKEAGLCSFFHAYPTYSQDGKTCHVDIEKMVRRRLFHGIPRPITNLKVRKLCSQSRKRRNVATQNAENFQTLRDTEEIREDVYKTLRKELYENVVADIKRDVTPTIMKQIHEEIKRSEHRELESFRIKTIEKTKEKISDEIQQTAQNMRNRKVVEMVKRITNEVMEEGDTIRQQLHREMIERITNEVIEEEEDNRRQLGDGRNGRGRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1R1</accession>
    <name>A0A914Y1R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1R1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13167.t1">
        <property type="protein sequence ID" value="PSU_v2.g13167.t1"/>
        <property type="gene ID" value="PSU_v2.g13167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13167.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20903" checksum="8A201A9C1DBD0D90" modified="2023-02-22" version="1">MHELIRVVEKDQIFGPVICSVVVVEFQKRGLPHCHCAFTLKEKWDTPEKVDAYVRGYLPPKNQEEADASGEVYDKEDYENTIKFMIHTPCGIHNPDAPCMVNGKCKRRFPREYREDTEMDVNGFTLPKCPENERSFTMKVKGKEVTVDNRWVVPHNPHLLKYMKSHLNVEAETIKLLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y243</accession>
    <name>A0A914Y243_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y243"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13527.t1">
        <property type="protein sequence ID" value="PSU_v2.g13527.t1"/>
        <property type="gene ID" value="PSU_v2.g13527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13527.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22053" checksum="6FD3BAA3A7D83FB8" modified="2023-02-22" version="1">MSKASTYKDLKPKLNFYLFSALSQLTFLEELNLSGNLLSSLSTEISQLPSLQVLRAHSNRITNIPDLSFSKSLKIIDLSNNRLLKLKVEYCVGENLKFLDLTCNPFSDETNNLSIKSERRAISIVDISKRSALSNIQFGFSETPGQKTKQSTQQLRPKNLNDITFAIIDGGSNPEITDVVKSTLKHHLETPVRIVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y273</accession>
    <name>A0A914Y273_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y273"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14274.t1">
        <property type="protein sequence ID" value="PSU_v2.g14274.t1"/>
        <property type="gene ID" value="PSU_v2.g14274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037587458" evidence="2">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14274.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14120" checksum="899E59D7DA243B82" modified="2023-02-22" version="1">MCYVRILTLFSLFLLVSSSTLDISNQWSIRAINEDCLEKAQSHDCSIFNRCCNYRCKQFTGHESKSHFCMAILGQIVTERTECACNSAVSLRTLTDRQGILAKFDLIAGIVLIFIIDIVLLSFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2C2</accession>
    <name>A0A914Y2C2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2C2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13601.t1">
        <property type="protein sequence ID" value="PSU_v2.g13601.t1"/>
        <property type="gene ID" value="PSU_v2.g13601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13601.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9041" checksum="50971197768A973A" modified="2023-02-22" version="1">MLLNGVEELFVLHYSRASEDHRRTLLKLIGILPYDEKVAAVLFSYDLVKILLNASGLIPEAIKVDGFRGKYFKIEFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2C8</accession>
    <name>A0A914Y2C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2C8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14326.t1">
        <property type="protein sequence ID" value="PSU_v2.g14326.t1"/>
        <property type="gene ID" value="PSU_v2.g14326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="189"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14326.t1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51109" checksum="6DB2C195E2CCADD7" modified="2023-02-22" version="1">MYRQKIKGLLDLGERCSFNEQCSTRYAQCLGNQCQCISGTLRRHQQCVTVQQCPLGDAPLENGYPLICDRNTLKCPEGNYCLFAQFTDSRGFCCPTMKVNCPVGSPLSYGCASCPWETHHCFTYSIGTHQQSMCCPNDCPRAMPIRHGDKCYAIVGHLNHCSVDEQCLSVQNSVCLSITTNETTKICQCPINHILIDGICQKVSKLGGECEKDSDCFIGSNTVCRNGYCKCGEGFMPESIPLNWKNEKKTAFSIEHCIAEPTCPSIHGLITIEHYEDCSTKSGCSEGKFCHQWFEDPLKERNYSLCCPIPNVRDYEEICGKFGMKMLLTNELDIQQPQQNAQPFRCMLPTFHRGIESGATATAKFIFENSSTICPLDSACIFNPFGIQEGICCRYEQKRRIGPHRKSAAKATIEKSQIFFPSSSSSSSVSASTSSVSASLKESFSGKINGLFRFPFKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y303</accession>
    <name>A0A914Y303_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y303"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14559.t1">
        <property type="protein sequence ID" value="PSU_v2.g14559.t1"/>
        <property type="gene ID" value="PSU_v2.g14559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14559.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17103" checksum="028CDC8314DB2588" modified="2023-02-22" version="1">MSIKEQCEVIAKLIPNVDIDVAHRLVSLVERLRASTDSGIRGISISLSLRRLIYILRRYTQNPDEGIFNAIHRSALSRFMPTITRTAFDKALSEAGIAKAGSSQDDSWKERLLETSKKSSDSVEHESMVPDIVFFDNKQVCFNLNKFRNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y539</accession>
    <name>A0A914Y539_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y539"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12814.t1">
        <property type="protein sequence ID" value="PSU_v2.g12814.t1"/>
        <property type="gene ID" value="PSU_v2.g12814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038125196" evidence="1">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="141"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12814.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31428" checksum="31009C2844A1A246" modified="2023-02-22" version="1">MTNDLFICLGLSCFVFLTFANEDNGGWQLPGEERFGYEGPCTIDRIDGKKLTQDEFLSEYAYTKPVIVYNVDNSHFKKICEKDEMLKEWSDADVVLNSANTYSYSRIPSTFGAYIEKHLKPQNLSTLGNETLYLFGDIDQSLWKPLLDAYQLPAWTVPNHDPALSFGIAGSGTGVPFHFHGPGFAEVLHGSKRWFLQPFNKRPYFNPDKSSLDWYLNEYPKLKSHERPYECLMKPNEIIYFPDKWWHATLNSETSVFISTFLSPSPKVTAKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y591</accession>
    <name>A0A914Y591_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solute-binding protein family 3/N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y591"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13939.t1">
        <property type="protein sequence ID" value="PSU_v2.g13939.t1"/>
        <property type="gene ID" value="PSU_v2.g13939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13939.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13810" checksum="AC8142E5945E5639" modified="2023-02-22" version="1">MPKKVLKLIGFKEYAPEVTFTSKCHQWSIQSCEQPGSDVEFLKLLFEFADINYEVIQKEMPTSEEIIDAVENGTADMSLISLIVSPDRLKKVAFTIPVNYLQFGYRGTKRLRIGSISIKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5B1</accession>
    <name>A0A914Y5B1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5B1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15391.t1">
        <property type="protein sequence ID" value="PSU_v2.g15391.t1"/>
        <property type="gene ID" value="PSU_v2.g15391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="87"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15391.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39692" checksum="9D52356CEFBB0E53" modified="2023-02-22" version="1">MAGRHLGSRRYSEFVQLNKVLKDEYPDFEFPKLPKKWPFKMSEQQLDSRRRGLEQYLEKVCAVKVIADSDIMQEFLMEDSNACRPVVDVNLRVLLPENKSLVLDVKRNSNTKFVFTEVLQQLNVSADATPYLALFEMIDLNFERKLHLDECPHNIYIQNYSSAASSCILLKKWCFDIEAEKLICSRDQLFKRICFYQAVNDLNNGLIQVSEKLYQLKALQTEDRIDQYLEAVRLLDGYSSVYFPECPFTCLDDHGYAKISCNFDKLTLTLMKSGSKKEKIISLQWNQVSSWKTVAECQVFSITFLKAETEVEIQLETLYTRYMTDVIERIHKERSRALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6Y4</accession>
    <name>A0A914Y6Y4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6Y4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15971.t1">
        <property type="protein sequence ID" value="PSU_v2.g15971.t1"/>
        <property type="gene ID" value="PSU_v2.g15971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15971.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13382" checksum="60494A1E7D40578F" modified="2023-02-22" version="1">MIFIYLGGKIFVSMFIVIIHAIFQQKDDIIKEKFCQVDHDIELEKIVYDRQVDATIKKYDEHVAQVKDRVIGNLLDLVIDIKPEIHHNFKVRKEINETGTYTRIIDPLHSASRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y758</accession>
    <name>A0A914Y758_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y758"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13465.t1">
        <property type="protein sequence ID" value="PSU_v2.g13465.t1"/>
        <property type="gene ID" value="PSU_v2.g13465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06720">
        <property type="entry name" value="PDZ1_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06793">
        <property type="entry name" value="PDZ2_APBA1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01208">
        <property type="entry name" value="PTB_X11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000007">
        <property type="entry name" value="Amyloid beta A4 protein-binding family A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000207">
        <property type="entry name" value="Protein CBR-LIN-10, isoform a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF16">
        <property type="entry name" value="X11L, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="11"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="204"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13465.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="42326" checksum="474C6B6AF241A407" modified="2023-02-22" version="1">MVHEPAVLIEGVLFRARYLGSTQLTCDGRPTKSSRMAQAQEAVARVKAPEGEIQPSTEIDLFISTEKIMVLNTDLQRISETDVRQDILMDHALRSISYIADIGDVVVLMARRMPQGSSTSSDEEDLEIRRTPRVVCHVFESEEASFIAQSIGQAFQVAYVEFLRANGIDDPAYLREIDYQEVLNSQELLGEELDLFSSKETQKDIVIPKKVGETLGVVVVESGWGSMLPTVVVAKMEPNAPSARSNQLNIGDQIIAINGISLVGLPLAKAQQNIKNAKTSSAVRLTIVSTPPVVEVRIKRPDTKYQLGFSVQNGVICSLLRGGIAERGGIRVGHRIIEINHKSVVAIPHEKIVNMLATATGEIHMKTMPTSMFRLLTGQEVPNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y783</accession>
    <name>A0A914Y783_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y783"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15129.t1">
        <property type="protein sequence ID" value="PSU_v2.g15129.t1"/>
        <property type="gene ID" value="PSU_v2.g15129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15129.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11650" checksum="9604453B9FCCD44C" modified="2023-02-22" version="1">MLVRVPEQNHILAQTFVFGHTNPAGIHHNGVVDEIGRKNFDSAITTMLCHPSFAENEALKKWFDSQQNILYERYGIEARLKAGYGFDKAHTNGMECNNRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y787</accession>
    <name>A0A914Y787_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y787"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15134.t1">
        <property type="protein sequence ID" value="PSU_v2.g15134.t1"/>
        <property type="gene ID" value="PSU_v2.g15134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15134.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17171" checksum="4B660F5C6C514048" modified="2023-02-22" version="1">MGKPYIRLNKDDAAVLLVDHQTGLLSLVRDIDPDKFKNNVLALAAAAKYFKLPTILTTSFEEGPNGPLVPELKEMFPDAPYIARPGQINAWDNEDFVKAVKATGKKQLIIAGVVTEVCVAFPALSAMEENFEVFVVTDASGTFNQITRDSAWNRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8E0</accession>
    <name>A0A914Y8E0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8E0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1502.t1">
        <property type="protein sequence ID" value="PSU_v2.g1502.t1"/>
        <property type="gene ID" value="PSU_v2.g1502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF2">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="287"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1502.t1"/>
        </source>
    </evidence>
    <sequence length="496" mass="55153" checksum="E5076A08957642EF" modified="2023-02-22" version="1">MYVVVGGGVAGVCCVQELVQLLDNYSTSSSNSSSTVLNGPKITFICGSAGFIKTVDEVSKVTKVLETIKVKESPVSSYFPTDKVKVIQENVKSWDSKKKILFLSNGDQIIYDKLCIATGASPINNFENENVLTLRDLDTVEILKKRLETARRVVLVGNGGIANELAYELKGVEIIWAIRHLTIAASYFDKQAATLFLPRLAAGRLNESLKPEAVRTRYTISSHIESTSEADPSTSGGCALGPYWLSKLEQKDGNKKRKVHIIKDVEVANIENWDISKHSTLTDLPDEFEADTNGWKAFVLFSNGETVGCDLVIFGIGVTPNSEIWKNGNSDLKIANDNGIEINDKMETSIKDVYCAGDICTAKGFHSKHWSQMRLWTQARSMGIYCARSMLFKDVEADICFEIFTHNTNFYGFNVVFLGDFAGEHLETPYDADVRCSPEQEYIKVLTKDNRVHGVVLVGETDLAETFENLILDQTDVSPIIDDLLNPHFDIEDYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8J5</accession>
    <name>A0A914Y8J5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8J5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15770.t1">
        <property type="protein sequence ID" value="PSU_v2.g15770.t1"/>
        <property type="gene ID" value="PSU_v2.g15770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15770.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17008" checksum="A853BA20BE752496" modified="2023-02-22" version="1">MQLLMETNENARKVLALLLCRGKFDVRQQVLIILRNMLINLPSSIPLLVEKQTITGLSDLLTVMHPDTVILALEAIKAILEHGGTSMTSEGGESSFSFLAEEANVNSRLDFLVSSPNENVALLAMELLHEYIDQSDDDIVLPDDLIDLTLHPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y986</accession>
    <name>A0A914Y986_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y986"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16759.t1">
        <property type="protein sequence ID" value="PSU_v2.g16759.t1"/>
        <property type="gene ID" value="PSU_v2.g16759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16759.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37715" checksum="DE1EB83804FDAB81" modified="2023-02-22" version="1">METEEEKRVRLQKDAETKQIKRENETENEKNERLITVKEQMSVKRTIKKLEKQEKLKKERAERIEVLKKVMPFVVRKGGEFKNVEPFKLGKRDKICKGCGAKHYRTEKRQQDGTYTSCCKQGKIKMEAGVPDYPQNLKDLMTKKYKNDKYVKVFDANKRMINSSLSCAHMYAKNVNLAPGVPYLKIQGKVLHKMPRTYIPSGDNATFAGQNYIVDSAEATVARVQAGLKNNIKLNEELMKELDETIREVNIFAQAYTMLKETMEKQKAHEAATGEKSNELRLVFKGKPNAKRNYDRVEAENEIALVYTPGPDGEIPRDDINGIHVLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9A2</accession>
    <name>A0A914Y9A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9A2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15860.t1">
        <property type="protein sequence ID" value="PSU_v2.g15860.t1"/>
        <property type="gene ID" value="PSU_v2.g15860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15860.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14427" checksum="7EFF6DDCF5B7FF49" modified="2023-02-22" version="1">MKPLPLSWPRHVENVSKITDYSKTSPWKAQSTIEGCLNGDTKKHEGKKAESCLQKTSTLSLHIAAYENAIEASHSDKQTCVKFQGSFEFPRPGENQVSKPEVMQFKASQKLLNPNKEQHDGWFSYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9V8</accession>
    <name>A0A914Y9V8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9V8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1700.t1">
        <property type="protein sequence ID" value="PSU_v2.g1700.t1"/>
        <property type="gene ID" value="PSU_v2.g1700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1700.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25617" checksum="D60CB415B028E288" modified="2023-02-22" version="1">MINFDTIIWISTLIWTFVTPFVLLFCCKKRQEHGNPAGGPLIKSKRCNKAPGLNLDDPDLKSEDRPLGADKTGQTTDMLLQSNKKLSKNRASREPTVTKDQCDTDLRSFLSDKNQKQDAATKMLSLAPTQELEGGAAAEPKKDKIGKKGKGFGGGGKASLECTQNDSQIRTVQENVTQNDNTVEIPAKAVETKETTTKKAPEVGIDGKSTILGKSVFVGKSTVAGNNKTDPLQQPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAQ9</accession>
    <name>A0A914YAQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAQ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14584.t1">
        <property type="protein sequence ID" value="PSU_v2.g14584.t1"/>
        <property type="gene ID" value="PSU_v2.g14584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14584.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13731" checksum="B54F1DDCD050BD6C" modified="2023-02-22" version="1">MNIFDEIKGDRYYIRKRMIKSRQKGGDLVVKYVKNAPNLTWKIEFNEELINRYSNKVAASTFVEVNGDEEGEESFSVRIDDEFDEDLVEDIIAGNLPDEFIDLLQVDESNDEESDNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBI7</accession>
    <name>A0A914YBI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBI7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1664.t1">
        <property type="protein sequence ID" value="PSU_v2.g1664.t1"/>
        <property type="gene ID" value="PSU_v2.g1664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1664.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17510" checksum="56EA6C48D3D50ECF" modified="2023-02-22" version="1">MFVQKLKEKDEIRPYLEDQAMLKRGKYFKDHVLHGHGSEIQKKFDHYFQDDPYHYATICNGGDPEIEVEKEKGEIILTCKGYSMIIKTKSIEEAKHEWAYRFLRKTFVDRSVPNFFEKHLPDEMISLLNDSFHEITIPEPWENEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBK2</accession>
    <name>A0A914YBK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1758.t1">
        <property type="protein sequence ID" value="PSU_v2.g1758.t1"/>
        <property type="gene ID" value="PSU_v2.g1758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="729"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="396"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1758.t1"/>
        </source>
    </evidence>
    <sequence length="767" mass="89440" checksum="9C247E98E28C6DD0" modified="2023-02-22" version="1">MLILLFVSEWVADQQEDCSHVILKQPLSEFVLECFDKLFKDIYYGKDEYFKDSFLMIISSFLNITPSVEKSVQTENESFLDLHSVTNEALTKDEKTINEADYKILQDTLNVKIMEMERINKLNADLIEERENLHQNFLQKNKDLENLVYQKQLEINNVLDKDESLNGFINNLQMELDTCKEALSIFTIENERLKRHNDSIKSNSNKEVALEEDKEAVQQLLDAKTLEINNMNELNVNLTKEKKLLEQELLEAQNKVIDANKLNALKESDTRNIFIEKDRLKEENNDLMKTVSNYSNVEMKLEEHKQKLQQVLDDKLLLIDEMSNGNENLVREKELLEKELMDAKNRLMDANNLIAQKESDNRNIIIENISLNDVIGNLTMERDTCKAELSSSFIENDRLKEENNDLIKVVRNYSSNEVKLEEEKQAIQQALDDKLIEMDEMSKVNEDITKEKKLLEQELLKAKRDLADSNYHIIQKEAEIKNLVDEKQSLDGIINKLQMDHDLCKDELSNGIIENDRLKEENEELTKVVNRKTRNEQKLEEEKEALQQVLDAKLLELDRTKQLLSNVQDELRFVVNKLRSLNLIKSELEAELNAFKMYFDQVTTSLSNTWANVKTLFDDFAAERLHNVSLSNQLETLQQEITVRERSRTPSLHDEGIMAYDSRRESFNGQCLFDGEHISQLMSFDERDEMRLDSGIGSNELTPEATPRDGVEQQQSIAHQSTSSVFSQYLMFTFLLILFYTIYIVTYGALVPSWVYIKLRHERMPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBU1</accession>
    <name>A0A914YBU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBU1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16228.t1">
        <property type="protein sequence ID" value="PSU_v2.g16228.t1"/>
        <property type="gene ID" value="PSU_v2.g16228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16228.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17086" checksum="2D8C2ABCA5DB8BD6" modified="2023-02-22" version="1">MAQNLLYKKWHLIAIVFPKYLDDQQVSHNGVITEIAEDLTEFVNSLGIFLNDLEEISHLWDSRSPNLADVILKNLEGILKCFPFLKHIETHRQKLQKMLCDETFAAATAQFEKDRLNDPSVFICTTFDNLIKPVTQSPENTGIKISKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCE1</accession>
    <name>A0A914YCE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCE1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15139.t1">
        <property type="protein sequence ID" value="PSU_v2.g15139.t1"/>
        <property type="gene ID" value="PSU_v2.g15139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15139.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17404" checksum="2EC84509E3573550" modified="2023-02-22" version="1">MLRRPLIKIFKGVSISLTTGIGIGSIYFLHQNDYELSSIGAVRFARAGIAASTTIADYKWSLMGVPEGTEKYQIKMKECHQRGADRLLNLAKSNGGVFIKVGQHIAALQYLLPDEYTSTLSILHSRAPPSDINEIKKVFQESVGKEVSYVHTYVICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCN6</accession>
    <name>A0A914YCN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCN6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17193.t1">
        <property type="protein sequence ID" value="PSU_v2.g17193.t1"/>
        <property type="gene ID" value="PSU_v2.g17193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17193.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23359" checksum="401C3E3423673D8E" modified="2023-02-22" version="1">MIQNPFEFPRQQGSQNIEPEIMQFKASQKLLNPNFSEKVPRQSEKDKLESIEKPQQIQKDFAKSGDETDMNKSSKESTRNGKKLDLSSIRDSIKVAKINQQRNSPNKEVPGKNGGGGGAAKTIYTKSGESNFDKSTFESTMEASVKFVSAESLTDEIVVPVGKTSRTPVPQSSLTSLNNLKIHGQPRSEVAVKFGEERISIKRTKSLNEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCU6</accession>
    <name>A0A914YCU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-beta PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCU6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17254.t1">
        <property type="protein sequence ID" value="PSU_v2.g17254.t1"/>
        <property type="gene ID" value="PSU_v2.g17254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLC-beta PH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17254.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18850" checksum="F4356D703988919D" modified="2023-02-22" version="1">MAKEYKFTFSSSIPKPLLDGDQFDRYDDETCILDIGCTVKFEENGFYIVWEPKGKDAGLLDISQIWEARNSGTIKDAKIIFDLEQRPTKESVEDRTIWITYGWDLVNVSSLFLIAKTAQIAKDWRDGINGIVHNYKLRHACPTTALQKQYVIIIFLKTDKEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD75</accession>
    <name>A0A914YD75_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YD75"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17248.t1">
        <property type="protein sequence ID" value="PSU_v2.g17248.t1"/>
        <property type="gene ID" value="PSU_v2.g17248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17248.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28873" checksum="7CBB64AE0B507346" modified="2023-02-22" version="1">MLQMDKEPIIEAIPETNGIEFTWASIAAAFFVVFIVTVFLILKSRRKQKNTFLIVGLSDSGKTLIYSKLINKDVNHTTYTSLKENVYNKLSTKHGEENRLVDYPGAEKLRTGLFDNWLKKELPFVRGVIFVIDSGTFNRKLRDVAELLYDVLYQLKMNKSLSTPLLIACSKQDNSLAKSEKAISDALEREFGLINISRAAALSSTDGRAGGKLLTLSGGDFSWMDLKMGDLNFYPTSAIETDEFDLKNVREWINSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF07</accession>
    <name>A0A914YF07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DDHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA-PLA1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YF07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1886.t1">
        <property type="protein sequence ID" value="PSU_v2.g1886.t1"/>
        <property type="gene ID" value="PSU_v2.g1886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF48">
        <property type="entry name" value="INTRACELLULAR PHOSPHOLIPASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="DDHD" evidence="3">
        <location>
            <begin position="186"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1886.t1"/>
        </source>
    </evidence>
    <sequence length="644" mass="75342" checksum="7D1F341D5B2E1999" modified="2023-02-22" version="1">MNITEYYYQPVPSLLIASLKSYAGYLKLSNGCPTKFNDFETDYSDLLFVVHGIGHHKGEEDIVQNGYDIRKGFAQYIKKFHPDSKLPMIIPVAWRHNLTLNDHMILETPFLKFPFGKEIGLVFNDIFYYIKGYKEVIEDSLISNLRIKYDKFLKRNPNFNGRISILAHSLGSVITFEVLQNKYKSLPFNVHNIFLIGSPLARFLASDGQEKINQFKKNPWIANGRLFNILHSLDPVSHRLEVLFNEDYKYVEPSELYLYNEFRRHYFRKMEISENERKEVISFYNRINCDRRLGKNHDAFLQFESATYQYAMDFYKNGNKTVLAQVLEQFDKNFGKRIIWNNETTKKMIEPNEKVPHRLDFDISKTEYSDLQHMEVAIERKFAGWTKELLLSHLSYWSRPEVIALMTNIIYNFDTIPSCNNTVSPYIRQYILRLSWSEWFQQFFTFKIMRWIAAFGIAYLIFCVIYAFFDKSGLAGITSIWPFLTRQLIQIYASFAVIVGLWCLTDPGDISRIAILFNAPDEYVFAIYIIVFIPAILNLLITENQANIDMLFRFIYNFVFTLLALTAIKAAYIELAALSRNYELDCRNPTENGRCLEYVLYNTETKLAGPAKTTLSAISDFFSPFLHGTVKNYVGEIRNLFFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFJ5</accession>
    <name>A0A914YFJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFJ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18222.t1">
        <property type="protein sequence ID" value="PSU_v2.g18222.t1"/>
        <property type="gene ID" value="PSU_v2.g18222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18222.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18575" checksum="473D46BF63A8073D" modified="2023-02-22" version="1">MYICKVYASIWASWSAWSFCANNVQIRVRACNTVRGFTCPGANQERKPCGQSASQNRGMRQRQRVNTFGGDYDAVDPWEEDRREALKQLYSDYTPPDEPQKPPAPPLRSIGKSLKPSGDFVAVQRSAGKTAFGSNGYGNGPPIAPLRPPPENGFNKKFHADGPGQAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG77</accession>
    <name>A0A914YG77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG77"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16343.t1">
        <property type="protein sequence ID" value="PSU_v2.g16343.t1"/>
        <property type="gene ID" value="PSU_v2.g16343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16343.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10174" checksum="3EAB2EB33B0470C0" modified="2023-02-22" version="1">MNDFDKEQQNAVSKQDIEMLKAQTRVLTIIVGDDRISHPLAETQSLSSRPPSSHSLHSSENGFYIPKCNKGDLEESMISNVTNCDRTFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG90</accession>
    <name>A0A914YG90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat domain phosphoinositide-interacting protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YG90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18462.t1">
        <property type="protein sequence ID" value="PSU_v2.g18462.t1"/>
        <property type="gene ID" value="PSU_v2.g18462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18462.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39613" checksum="AC69E9C8E5316605" modified="2023-02-22" version="1">MPIVRQISFNHQQDCFALATDEGVRIFNTDPLVELIHLKSQDVGSVRFVSLMERTNLVAIVSGNPRPKFANNVVMIYDTKQRKFVVEVAVGSPVLNVAMTQTRLIIVQHSQIHIHNTDNFQLVRSEETVFNPNGLMAISPDNKLEFLAYPGTKPGSVQLANLQNTSHSRSLAPSVIFAHKSPLARIALNNQATRIATGSSKGTVVKIFDTRTRELFYELRRGVDNAALHCLRFSYDSCYLLVSSDKGTVHVFSLKDSDGERQPSVQKILDHMRFANERRSIVQFSLPNFEQIVECAFTSNSVTSGLSSEPGLNKDVITIGYDGTYFRFSECSSKPQGHELLFDLAADQEFWKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHG0</accession>
    <name>A0A914YHG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHG0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19764.t1">
        <property type="protein sequence ID" value="PSU_v2.g19764.t1"/>
        <property type="gene ID" value="PSU_v2.g19764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19764.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="32391" checksum="3704BD3B80B36CFC" modified="2023-02-22" version="1">MASNRKIILKAEYNFLAKVHWMNIDTRKHEEKTFLPNPNASEYVKQLFKESKLQPKDIKAIAFIYNDCEFDTWKQTYEFRQGCYEFCQKNDIFYYSSTTLAFHNFIATFRSKSVGKEGDHLTVIYAEMNGVLGKTFVRENGRWRCINIHITSEFQNTQEWKHQFLKNYTPKKIVFMYHMAAFDFKQVIDLLKVKNSIVLPPDYDYLTTASIDKILHVMGEKPIPYDITPQCPNVYAVNLGRHNIISATYEDSLPFEKSGIIDVNPSKTLTVSYFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHP7</accession>
    <name>A0A914YHP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18843.t1">
        <property type="protein sequence ID" value="PSU_v2.g18843.t1"/>
        <property type="gene ID" value="PSU_v2.g18843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000001">
        <property type="entry name" value="Carboxypeptidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="10">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18843.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36260" checksum="165C83866FC803D5" modified="2023-02-22" version="1">MEVSSYRSSDAIDPDNFDFYNYHPFAEIMGYIQAVAQKYPSFVSISSLGKSFENRDTQFLKIGYPSSTAKNALFIDAGMHAREWIAPTTALYAINQWVTNSSYTDLLKAIDIYVAPCINPDGYEYSRTKDRHWRKTRSGPRQGCYGVDPNRNFSFKWMVSGSSTNPCSETYAGPTPFSEIETKNLKNFLVPHNDTIKAYLTLHSYGENILYPWAYAVEEYPPDVNDLIALGHEMYSAIKAVHGTKYTVGDSGDTLTPAPGASDDYSKSIGIKYVYDIELRPGDGDNDNDDGYGFDLPPKFIKPTAEEMFPAFMAAANRVQNGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJB7</accession>
    <name>A0A914YJB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Alternative oxidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19602.t1">
        <property type="protein sequence ID" value="PSU_v2.g19602.t1"/>
        <property type="gene ID" value="PSU_v2.g19602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19602.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36156" checksum="226E04F8A85592C9" modified="2023-02-22" version="1">MLNRCGTNVRSIPFSLIGIVGNKVFSKYAVSMPSSRLFITAAHAKKPTEKEIKESPDVVDATYPTKEQLAQLVERHQVLGVSMPVRSEFIRDSPLKFDDLEAIDIKVYHRKAVSISDHIAFRTVKILRFFADSFFRKRYVHRAIVLETVAGVPGMVAGMFCHMRSLRRMQNDSGWIEKLLHEAENERMHLMIWMAVTKPTYLERVLVTLVQGVFFNIYSFFYLFFPRTAHRMVGYLEEEAIVSYNSFAAQIRNGNITNDAAPKIAISYYNLDKNARLLDVVYAIRADEAAHRDTNHHFADRIDARNENLSEKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJN1</accession>
    <name>A0A914YJN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17518.t1">
        <property type="protein sequence ID" value="PSU_v2.g17518.t1"/>
        <property type="gene ID" value="PSU_v2.g17518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024858">
        <property type="entry name" value="GOLGA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881:SF46">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17518.t1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49518" checksum="8EC158E6B539038C" modified="2023-02-22" version="1">MEDKEARLLQARQILKKYQNKHNGDSTNHLNGHESCSDAASMQSSRASSVSDMVKINNHNNLNENQEVIYLKKALDEKDQTYRDVVQKLQTLQTHYAELHTAYNLANQTLQSSTSPEFAEQITRLQGALSVAIEEKTSYQSELRAANNKLLTFETENKALKEQIRTSTGSSNLHENEKKKLNEEIDRLARQLKHATSELEKQRRESLILESKIRQVNQDRNDFSSRLKYIFNEKEELEKAVASMKHELQMKEIFIKQLTFNDSEQSQHEKQHQESFINLTTEKERLLNDVQTLTTKLEESQRQQIAAREYYESCIGELNGKVSTFEEQLRISQNEKADFESSNYQLQEKINFMLSQQAAATIPPQNLSPGSDDVKRSQSAVALTQMTNNIDVVEMEALKNSLISVQNDYSRVVDKIREMELVINEKVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJT0</accession>
    <name>A0A914YJT0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YJT0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19116.t1">
        <property type="protein sequence ID" value="PSU_v2.g19116.t1"/>
        <property type="gene ID" value="PSU_v2.g19116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19116.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18165" checksum="A89E1D3ECB833B86" modified="2023-02-22" version="1">MSEESADVKDLKHQPCKSETPYQGAACVICLDTQLKDPTILDSCLHFFCYECINQWLLTNPSCPMCKKQLNKIKHNLSPLPEAFPVPYNSVSGDEKTVEDLLTDYEMGFLREQSYSPLNVERRCIEEAIELLYHKTIRLRNLESDGILTYVFIFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKE4</accession>
    <name>A0A914YKE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S54 rhomboid domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YKE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19342.t1">
        <property type="protein sequence ID" value="PSU_v2.g19342.t1"/>
        <property type="gene ID" value="PSU_v2.g19342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF3">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="345"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19342.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="47621" checksum="AC9E3BB7C758AC56" modified="2023-02-22" version="1">MRVMQPQPLAAAPSATTPIRYRELLIQKEENIEIPATRTFFQRLRRSFRNSFPSHTVKSLTSIIKTGNENKQKSENLPFGVSYKERPDVIDPILKRQLDNEFYDDRPYFTYYITVIQLIIMISALFRYGFGTTFTSNYFGVTEKSGDVLTATLSNVHIVVWEQNNIWIGPRYADLVHMGAKYSPCMRRDLKILEQIEEDRRIESEETGCCVSSEGCYQTSKQFSRFIKTITDSKGITNRAVCGQDPKYCRNPESVAPNRWSKDISKWPICKEVSTRIPSSEAHMKCEIRGRPCCIQMHGQCRITTKEYCDFVKGYYHENATLCSQVSCLGNICGMTPFLRRDHPDQFYRFFTPLFIHAGVLPMLVTIWIQFNYMRRFEILIGWTRTSIIYFASGIGGYLASAVFVPYMVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKT2</accession>
    <name>A0A914YKT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YKT2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19487.t1">
        <property type="protein sequence ID" value="PSU_v2.g19487.t1"/>
        <property type="gene ID" value="PSU_v2.g19487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19487.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11754" checksum="BBE8E0BBCC0576E0" modified="2023-02-22" version="1">MVGILNGILLTAPEMLAFRHKLKNPEENDCKELFECLYRCWSHQPICLISLCLLSKYYEHAAQLVPRLSEIDVSVDFLREIDRLVQLIESPILSCNLFIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKT4</accession>
    <name>A0A914YKT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKT4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17935.t1">
        <property type="protein sequence ID" value="PSU_v2.g17935.t1"/>
        <property type="gene ID" value="PSU_v2.g17935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF227">
        <property type="entry name" value="SYNAPTOTAGMIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17935.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15570" checksum="4D0DB50A7022057F" modified="2023-02-22" version="1">MPVQVLFYQNSYLSSAQRLSLSIQQATGLQRSGSENNNNGAPSSLVKAVLTFDGKILKKKKTTIKKNCICPIWNEVLTFEVDPRLISKCKMDLIVVDSCGGKILGSANLGENAGHGARIWKEALRGQSKVSRWLPLIAGPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKZ2</accession>
    <name>A0A914YKZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKZ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19543.t1">
        <property type="protein sequence ID" value="PSU_v2.g19543.t1"/>
        <property type="gene ID" value="PSU_v2.g19543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="entry name" value="Type II secretion system, protein E, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30258:SF13">
        <property type="entry name" value="SECRETION PATHWAY ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30258">
        <property type="entry name" value="TYPE II SECRETION SYSTEM PROTEIN GSPE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="MshEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="EspE N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Type II secretion system protein GspE N-terminal" evidence="5">
        <location>
            <begin position="49"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial type II secretion system protein E" evidence="4">
        <location>
            <begin position="167"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19543.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30121" checksum="64074E940EA0E965" modified="2023-02-22" version="1">MRFPSQGARNASEVHPLVLLSNLKLAARDGGELTLERLTEWLARRTGSRYLRIDPTRVDVAAVTALVSHAYARRHRFLPLAVDAERVLVATSEPLVQEWRRDLQHLTRRRIELAVVNPLDLHRYTMEFYGVTRSVRGARGDVRGEANTTLPSFEQLVELGRTGDVNADDQHIVHIVDWLLQYAYEQRASDIHLEPRREMGRMRFRIDGVLHKVFEVPPAVMTAVVSRIKVLGRMDLAERRRPQDGRIKTRSPGGREVEMRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL28</accession>
    <name>A0A914YL28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-hydroxybenzoic acid efflux pump subunit AaeA</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20243.t1">
        <property type="protein sequence ID" value="PSU_v2.g20243.t1"/>
        <property type="gene ID" value="PSU_v2.g20243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.170:FF:000002">
        <property type="entry name" value="p-hydroxybenzoic acid efflux pump subunit AaeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058634">
        <property type="entry name" value="AaeA-lik-b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058632">
        <property type="entry name" value="HH_AaeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050393">
        <property type="entry name" value="MFP_Efflux_Pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30367:SF12">
        <property type="entry name" value="P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30367">
        <property type="entry name" value="P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25963">
        <property type="entry name" value="Beta-barrel_AAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25878">
        <property type="entry name" value="HH_AAEA_pHBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111369">
        <property type="entry name" value="HlyD-like secretion proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="p-hydroxybenzoic acid efflux pump subunit AaeA alpha-helical hairpin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="p-hydroxybenzoic acid efflux pump subunit AaeA-like beta-barrel" evidence="8">
        <location>
            <begin position="72"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20243.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21366" checksum="22B48A783BC2EDBA" modified="2023-02-22" version="1">MSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPADGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTRDDKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRKMAHRLREFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLF7</accession>
    <name>A0A914YLF7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914YLF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19734.t1">
        <property type="protein sequence ID" value="PSU_v2.g19734.t1"/>
        <property type="gene ID" value="PSU_v2.g19734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F59C6.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19734.t1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39944" checksum="B3B01ADE72950EF7" modified="2023-02-22" version="1">MATFIFNSRNLSTKWSRYANFLYSKYPRGITQFIKYIEKWVLIELGNQNDEINPNEHLAWRNQAASHTDCFLKYREAAEFIIVADIDDILFPQLGKRYLDEFRHLSLQYPFAAGFTYNRTHLKVSAHKSPKDFSLPKYLSSLKQTNEWGSGKSVVIPSRVQTVWLHWPIIIEKGYKMINVPNQQNIMLHFTKWNMLNSTFKNELSESDTVITKNEDDAIVDKIIQSINSTNLKINAEKFLSEINAMQIYESLPTNIIYYPLIEKCYFDIFYSKSSNHRLQNVKAYNPESCPGPIKCQLPTFPGISCIVSKRKYLHKFISENLQIHYPSKKDIFQKSDNGCTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLW0</accession>
    <name>A0A914YLW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maturase K</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLW0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18304.t1">
        <property type="protein sequence ID" value="PSU_v2.g18304.t1"/>
        <property type="gene ID" value="PSU_v2.g18304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18304.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12840" checksum="A277F9E1F4648217" modified="2023-02-22" version="1">MNWKPDSDIPEAQSSTQVFEKLCGKLACFSPLVRESEATKLVRVWNYFSKQILGDRHDNQFVRNGIIIYFLPFLDNYFRFTIIHDFKGIIKSINIFCLFKFFRIFTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLZ9</accession>
    <name>A0A914YLZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18344.t1">
        <property type="protein sequence ID" value="PSU_v2.g18344.t1"/>
        <property type="gene ID" value="PSU_v2.g18344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18344.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="19863" checksum="256C51A0061729CF" modified="2023-02-22" version="1">MSQKVMEILEQFLKKSDDYYIQKGCLYALFIHIAVYHKDKDETKKLLKLAFDCPKHKEDPKLHFFLLFVQRKYVSRDKRKELSTKMFERYERFKNGRMKEEKLDAFYNLYEDYFFEDNMIKAEEMLWKIYSDKECLKMDKKGFVKKNLITCKFLLFYRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM58</accession>
    <name>A0A914YM58_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reactive oxygen species modulator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein MGR2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YM58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2000.t1">
        <property type="protein sequence ID" value="PSU_v2.g2000.t1"/>
        <property type="gene ID" value="PSU_v2.g2000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2000.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="8478" checksum="F5ADA5EC9299FCC6" modified="2023-02-22" version="1">MPVPSGYQTYGGGAQGPTCFQKLKMGFMMGAMIGGATGVLLGGFSAWRMGLRGGEMFKQIGKVAASSGGSFGVFMTVAQGLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ81</accession>
    <name>A0A914YQ81_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YQ81"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2976.t1">
        <property type="protein sequence ID" value="PSU_v2.g2976.t1"/>
        <property type="gene ID" value="PSU_v2.g2976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="133"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2976.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34236" checksum="8C251500C4CC1EFF" modified="2023-02-22" version="1">MAVEGPTSFEDLRTVNGTVYETNREACVALGLVINDKLYLFARLLAHCDLGNPLELFEKFEQHFIKDLLKKWSKDDAIKVAWRRIVKSMLNQDKQLSDYPELNEYMKAIGTQDEDTLDLKALLEKGEKMYDSLTNEQKPIVDTVVDKLKNPKNGTVCIFVDGPGGTGKSYTFNTIRNLAYGMGKKVLIMAWSGIAASLYPMGRTCHNAFKLDFPFENDSNSSVKPASEHGKMIKEADLIIWDEFPMAPRHALEIIDKKLQEIMENTVTMGGKILCTGGDFRQCCPIIENATTEEIINASVCCSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ95</accession>
    <name>A0A914YQ95_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
            <shortName evidence="12">DAG kinase</shortName>
            <ecNumber evidence="12">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914YQ95"/>
    <dbReference type="WBParaSite" id="PSU_v2.g220.t1">
        <property type="protein sequence ID" value="PSU_v2.g220.t1"/>
        <property type="gene ID" value="PSU_v2.g220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20799">
        <property type="entry name" value="C1_DGK_typeI_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000089">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000003">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF48">
        <property type="entry name" value="DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="14">
        <location>
            <begin position="221"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g220.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58169" checksum="6291A5E731DE34AD" modified="2023-02-22" version="1">MMNVARYQQWDTIELEPILRQMMAEIDYDNDGIVSLEEWKRGGLTTIPLLVLLGFDNEMKEDGCHIWRLRHFSKPTYCNVCCNLLVGWGGKQGLACSLCKYTVHERCVRNAQNTCIHTYNTNPTKDTVMIHHWLDSNSAAKCAKCKSTVPIFQGKRCRWCHNLLHTKCIELWPKECDMGSLAYHTLPPVNIIPSFLDRSQSQNSNFVQGNPTKFSVTNLPPNRRPLLVLINPKSGGRQGERIYRKFQYLLNPRQVYDLIKDGPENGLHLFKSIKNANILVCGGDGTIGWVLDAMDKMDYGENRPPVAVLPLGTGNDLARCLKWGGGYENEPLQKILHSIEKASQIYMDRWQITIEQTKKSDKGDPQPNHIINNYFSIGVDASIAHRFHVMREKYPEKFNSRMRNKLWYFELGTSETLSSTCKNLHEQIDILCDGETIDLGNGPNLEGIALLNIASIYGGSNLWGNSRKSASGFHIPILFPQITNNAVYGLQNRVQDIGDRLIEVVGLESAIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQM2</accession>
    <name>A0A914YQM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g232.t1">
        <property type="protein sequence ID" value="PSU_v2.g232.t1"/>
        <property type="gene ID" value="PSU_v2.g232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g232.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12871" checksum="DA3BA9D54CB30475" modified="2023-02-22" version="1">MNFMQVQMISSSGGNYGLSSRQQYYSRPTPTYGMESNEDEEPQQQEQEIARKPWPAWQHQQQYRQRQSQHHRRLVPFAVAPILSSASYEKSREIGYRMIPERVRSFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR34</accession>
    <name>A0A914YR34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR34"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2637.t1">
        <property type="protein sequence ID" value="PSU_v2.g2637.t1"/>
        <property type="gene ID" value="PSU_v2.g2637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2637.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16369" checksum="09AA4987D52A0076" modified="2023-02-22" version="1">MVDIKFNGEYLTSSRGVQKIVQIILGFVVCSVLCANWYGGTSCFGDGRLGYVSGLNFVIVVMNIILFLLNMMNIGTRRFERVYSLIVSILFIIAAGLMLWHIIATGFWSFWYIATLVALVIIFFTLMWDYRLLSDEHRDHLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR35</accession>
    <name>A0A914YR35_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1984.t1">
        <property type="protein sequence ID" value="PSU_v2.g1984.t1"/>
        <property type="gene ID" value="PSU_v2.g1984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="344"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1984.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="42195" checksum="50D2B2A5E616B358" modified="2023-02-22" version="1">MHKGVYGAGLSKSGALSIRYLVEKRTAPESILRPLRIGFCNSKKITKIAAGCGFSLFANNNELYGSGLNNFYQLGGAVNDRKIDRSEQYYIGGKKIALPTDSGKILDIAAGRLHCLISTENKIYALGNNSHGQCGQDPEKHQFVTHNRANDQLLNILLPDNAKVVKVHCTLDTSFLLLNDGRILSFGLGEDGQTGNGIKGKTSWIPQEVGGDIKGEKIVRIGGSADTLLAANENGDLFAWGLNEYGQLQIVTDEIQVDYPRHLAFKLGSIVSVGATGSSCIISNSDGLVYTWGAQILGLGPEVSSIPRPMLLDPPLFSSVVNEDGIVSRVFSGCYSMGALTTGGNLFVWGVNRFGSLALGHSDDQFFPFQVFLPEQVRNVSLGPDHSLFITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR84</accession>
    <name>A0A914YR84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YR84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3276.t1">
        <property type="protein sequence ID" value="PSU_v2.g3276.t1"/>
        <property type="gene ID" value="PSU_v2.g3276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF1">
        <property type="entry name" value="PROTEIN MALE ABNORMAL 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3276.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32445" checksum="D3687DCA922D8741" modified="2023-02-22" version="1">MIVSDFVKVTTLTLIIAFACVIYAIPGQVIIKRFSKEQCKFNPCLNGGKCVPGKIACECPGGWMGRYCHRRCRNIYQSCDRWAMEEKCEVVRTQTNFFDINCAVSCKMCVADPSVKLSPIPLPPALEPLQFMMGKWYSQAAKGLRYPTDMSGNEYEEILDVMPAEVPMFGAPSLNLTCTAWEGDDIRITHGFLTIKPNSNPPEIAILSSSNEGLNMVELGTLSNHAVTLNISYMQVHPAMNNDILPLGATRRFKRSGQFLEMTVARLFPNKRISQFKKMFRKVKNYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRB6</accession>
    <name>A0A914YRB6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRB6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19924.t1">
        <property type="protein sequence ID" value="PSU_v2.g19924.t1"/>
        <property type="gene ID" value="PSU_v2.g19924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19924.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38497" checksum="9B2B003B215E87D3" modified="2023-02-22" version="1">MASAIAEQSNLEKLRNEINLYFHKMSSRDSTGKLALRILKYFSDIVTYAKYKTVDELIAILMSDGELLYSAHSSEFLIRNMLLSVLKIIREESLRQTSGMDETFTQTDSLNRLWFLPSDVNAATDIKKIKGGILVSLGEYQMEMENSVESLASKALQEFLISEYSDIVMTYKFSKSETLKKFFSNVKTKILYSVDDDPDAQANVISSIDILSTMRTTTRVIISAAAILPDGSCVSTAGTLSMCLAAKRHSVPVLVCASFYKLTPMFIPHLDEFNVHSSPVEILPASEALKFSNNVFIANPLFDRIPSNLITLFITPTAVVSPSHVYRLIAECYHPEDFRQLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSG3</accession>
    <name>A0A914YSG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2952.t1">
        <property type="protein sequence ID" value="PSU_v2.g2952.t1"/>
        <property type="gene ID" value="PSU_v2.g2952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2952.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="18711" checksum="E18C6A98CF1461E5" modified="2023-02-22" version="1">MLEIYQWTLFILFTQINFAVLIIHGCAKKKKGDEPGKLPKYSMKGVGAGGGGGKDENNNNGQSPANTPQSDGKKAGGSSKSKKGSTKDAKKGDGNKEPAKGAVVPALNKDHLVPQVNDAVKTERKGDAGGDKQKLVSNPIVSAVTEQFPTVAQPVKEQIKTDKTQSEAHTDKTQKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUN5</accession>
    <name>A0A914YUN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4333.t1">
        <property type="protein sequence ID" value="PSU_v2.g4333.t1"/>
        <property type="gene ID" value="PSU_v2.g4333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4333.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30001" checksum="7531103F043E95B0" modified="2023-02-22" version="1">MIQKNELKEEVVKLHETLEEFEKELAKMESSKKYKSPRTSLDTETIQMFRNMVRSDLRLNPQRVAEEEPEEEVRPDLRFNSQRVAEEEPEEEEEVHSDLHLNPQHVEEEEPEEEGDFFDQNSVDAIQLNVADEISPLHKLTPSPIRATPPDARPKPLHNYTPRNEDHLFKVPQPPHHAAPKNIVQTTDEDDMNNSLGLNTSDPVMDSQSGGPDFFNLLGNSSDNTGISFLQEHTNNSDTGGANFFFGGSSPRGQKDESSHGFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVI8</accession>
    <name>A0A914YVI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVI8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3997.t1">
        <property type="protein sequence ID" value="PSU_v2.g3997.t1"/>
        <property type="gene ID" value="PSU_v2.g3997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000049">
        <property type="entry name" value="Solute carrier family 12 (potassium/chloride transporter), member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF73">
        <property type="entry name" value="KAZACHOC, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3997.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38267" checksum="D8EA2636938D0A71" modified="2023-02-22" version="1">MGTIMGVYLPCLQNIFGVIFFIRLAWIIGTAGIVQAFFIVFLCCSVTFLTSISLSAIATNGVVPGGGPYYMISRNLGPELGGAVGVLFFLGTTVAASMYITGAVEIFLLYILPKAQYFENMYHNFRLFGTGLLCMLGLIVFAGVKVVNKFALPVVIAVIVCIICTFAGVFWKANGSESLQFCMVGDRPVNLVGFKEKFGYEPECTAEGLREAFCQNDENGTMLCDPYYLRYKTSKRFSIKKRPAITGLLNGSFFDNLWSKHLIPGEVLTKGNKNKEPKPLPHSLYVYSDSTTSFMKLIGVFFPSVTGIMAGSNRSGNLRDASRSIPLGTLGAQLTSSFICKIIIYFGYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVK6</accession>
    <name>A0A914YVK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVK6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4016.t1">
        <property type="protein sequence ID" value="PSU_v2.g4016.t1"/>
        <property type="gene ID" value="PSU_v2.g4016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4016.t1"/>
        </source>
    </evidence>
    <sequence length="927" mass="105036" checksum="C2A9E60295295606" modified="2023-02-22" version="1">MKMDEKVLKSDYRGIYGSFNADVFPTTFCSTKNHKSGYVEANDCVDIHIGILSDDDYFNGENVEGDGDNKVPAVDAFNTEETQHDVESLVEQSLSQVVSVRTQVLNFAVDARAAYFKLEHEVNLANARLQTMHHPAQKVSEEIMGEIKDHLIDNVEWLLAIFEEKDKSLERLRRENYDDVDDKNAALIENVKLRQKLEEQKAKPMGISASDQKKMLALGVNSFSELINRYRLLQVKAEDLDRRQTFDAPLSRVDSTSTFKSDKREKECQRSTPTTVKGGSRFISGHCAEISARVNVPIPLPEKFTGKTRVELERWLRYFNRAVDSRGFTDEDKATVLGNYIPSLQFTHDKLMRNRASFEEVQAGLLNALGTDSSAATYTLRTSLDRFKKPDNQLYKKVLEDVERKVLQAYNNDCDQGDDELKKILIRLVQEDLNPIFGSTLIPHFGESYTRLKELVLGVEASLVIHREADKKKDLKASDKGVKKIFGNHSSHYPPSYFTCNNERNFEGTQRDADKVTVQSSRTEVERYPSISEPSYCNPNFHRTKSITCFTCSKLGHYANECTEGKTHGVRQIKDLDALEMNGVVSVDVVDEALYDDLHMIGKKATLDVWLDSVKVNALLDSGACASVISETAIGKILKQRPKAIRRITQEDPKTFMHKRLVGANGSVLKIVNCVCMPIAWGSYPSKIVKFFVVSGLQQDVLVGTNVLQNDACWIEALGIALGCGKYNVHYDDVKECNGIGVYMPQMGINENYCFRDDFKTVSLSHNNIVSRPCKNVIVKDRNCKYQHCSNEMNTVIQDVKQRQVKKRIKEVNAPIYLPKECSRGKFRQNVIKKPAEVSTRGYSKFNTLKCYESRCRFARIPNYFNGYGNGHPLNYGCKRSPLVQSSAEYDPNWRNHEKVPGVKQIYDITSARGSTQSTPHPRSNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVM1</accession>
    <name>A0A914YVM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVM1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4030.t1">
        <property type="protein sequence ID" value="PSU_v2.g4030.t1"/>
        <property type="gene ID" value="PSU_v2.g4030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019254">
        <property type="term" value="P:carnitine metabolic process, CoA-linked"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4030.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31095" checksum="22EBB6B6365DB9DC" modified="2023-02-22" version="1">MHHRKVTALPLRLFEMSKSRGMNEVSKRLIYSKLPKLMPPDLNSTLKTFVEFAEPLQNGDNFQKTKQLTKEFVESGEAQKLHELLVERAEKLNNWLTPWWLNIAYLEARSPLPIITSPGVAFPPMEYSGEEGQIDAAAKIIQAALNFHHKILKDELPEDRAGKVPFDMSQYKFLFGTTRIPRKGKDEIRYGSSNKEWPKHILVTRNGHTFQVSVYDKNGNILGTEALEKQLRDFVIPNSQNRNSAPVNLVSSDGRDEWAEVYQRLESTVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVP0</accession>
    <name>A0A914YVP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVP0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3724.t1">
        <property type="protein sequence ID" value="PSU_v2.g3724.t1"/>
        <property type="gene ID" value="PSU_v2.g3724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3724.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33844" checksum="7AA5B3DC56175115" modified="2023-02-22" version="1">MRKLPTSPPPSEFPSDVLKWMKKSATPKLAFRLMFVCKYFQHQEFPYLIVEGLRGEDDQWNYLPLLDDTIAFVYEYIDLETTTKKLWITRGLDLTCNDNWAITLLPKIAVCDIRELNLCYQNITFEELKVLTASKTLTKLNLSNAFIKDENSENVPLEDILEAIPEIESVGIRINGNAFVTHQNAIEKVSTNLNNLNVWEIDDKDFKFEECFKFIQRKQEIQFSFQCDDSNFSDEIRQKLQLLTDNLFERWETRNPPPHISFQSQTAESKDKLEELWKLYHEKNNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW47</accession>
    <name>A0A914YW47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW47"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3877.t1">
        <property type="protein sequence ID" value="PSU_v2.g3877.t1"/>
        <property type="gene ID" value="PSU_v2.g3877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3877.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25529" checksum="E6EE3D8F0A5F66C3" modified="2023-02-22" version="1">MTAIDPYTGETYTATLKIKCGSENSEYGLYWKYNILTKFWRKITKLTIFVDYIAKKNETFKVDAFKAFQPKGTFERLKEIWEGDSSVKITIKGAKNQMEAIKPFLAAHSPVFKAMFETNMKETTDNVVEIPDFEFNIVQKMVEFCENNTILDCEGLEAEIFKIANKYLMDDLMEFAVTKMTDQASKENIKDYIELAKSFDLKEFEKWLMHFACRNNFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWN1</accession>
    <name>A0A914YWN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 65</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4954.t1">
        <property type="protein sequence ID" value="PSU_v2.g4954.t1"/>
        <property type="gene ID" value="PSU_v2.g4954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4954.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21279" checksum="946D23BD1977B58C" modified="2023-02-22" version="1">MFKFVIQKSLCHRSCTFNGGFRLKSTTFKRPFKISTIEEAQNIAKSLNEPERKLLSQALESLDGSTDIDKESLTPLQSRQLFTFNIIPFIGFGFFDNVVMIIAGEYIDQRIGTIFVISTMASAALGNAISDLTGIGLSQYVEKAALFFGVKHPELSPKQFMSKKSRFIIHSSRGIGLTIGCLVGMFPLLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWR9</accession>
    <name>A0A914YWR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWR9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4989.t1">
        <property type="protein sequence ID" value="PSU_v2.g4989.t1"/>
        <property type="gene ID" value="PSU_v2.g4989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4989.t1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56027" checksum="BB29A2B6C1EF34B5" modified="2023-02-22" version="1">MSVISQTENTTVLIYSGGISLAPGDNIHTIVTITNHSIWSTDNTLYYQYAPIQYWDVEQGMVKCPTMNGTCNMNVFDGNGWYEIPLMLNGQELDADLTVFMNFDQGTVYNNDFGMMFDPNILPCSSMETFVIVGPAYNMIFYYCCNNFNYVTVPDEDMMCTEFQGNSTLTDVSGNVLSSITANYHITPLGVRMNVVNAVLPADGTYDLNPNDDTNGCNGNAASQNCAVFYPIEDPTLDYQVDMILYFGQGEDTTIGTTIAGKITKRGQVILHDQNQPYTKANPCWHGNYLASQNKNQALNTLCCTKFEKPPSGTTCAEYQSITQVYQQGRNYQQQQHDDSSAKPYLQMKYQFNNTAFFVSILNFTNGISSNVQFESYSTDTFSQICKATTNSPTNSCTFKLSKTNQYDFKFRTSDMRDGFDIISVNEAQSQILNPSLIPANPCITKYNYDASQSFVATSQLCCIAEAGGPWPGSMKAGKTRQKSHNEKLTNKKTQTINKTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYG4</accession>
    <name>A0A914YYG4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="3">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="EC" id="3.2.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16302"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARM1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YYG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3095.t1">
        <property type="protein sequence ID" value="PSU_v2.g3095.t1"/>
        <property type="gene ID" value="PSU_v2.g3095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034128">
        <property type="term" value="P:negative regulation of MyD88-independent toll-like receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
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    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09502">
        <property type="entry name" value="SAM_SARM1-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24153">
        <property type="entry name" value="SARM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000043">
        <property type="entry name" value="Sterile alpha and TIR motif-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000101">
        <property type="entry name" value="Sterile alpha and TIR motif-containing protein tir-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000023">
        <property type="entry name" value="Sterile alpha and TIR motif-containing protein tir-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="691"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="837"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="986"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="997"/>
            <end position="1009"/>
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    </feature>
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        <location>
            <begin position="1010"/>
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            <end position="1075"/>
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    </feature>
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        <location>
            <begin position="1092"/>
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        </location>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="WBParaSite" id="PSU_v2.g3095.t1"/>
        </source>
    </evidence>
    <sequence length="1105" mass="123222" checksum="6E0F98D15A90E501" modified="2023-02-22" version="1">MTGISSENDKNKLLEAAVIMPMPSSTTTVTESERFQLSRQDAAVNPTKNLLGRTDDLLSELDDDFEPFSRDELEENEPVGPLKKPMISLYSLRSPAAIKSSFDSSTTIVNGTTTFACNGSSNPPLGTLEKSVSLSYADSYPPSPGEHQHHHSTGHYPSSSSSASQHHWRLSPMRSSYLPNGGISRQQSTLDESGPMFVQGSSDGLCNGNSDKTLRVCENGTHNGENKLQQSLSTPCPTGTVATTNNRKDAEYRRFKSEDIPGSGGGTPAPPSMDIAIDDLSPITDHRSSPPHRLFAVINHNKIPIICNDEFLILQTQDSVSTGPITKHSHTEQVMMMHTLKTKLQKYQGFIDKAFQLIQEGGDEQIFEGCTIVTKVMTKAWLFPKISHDLAYALCDYLRDQNYFDILIGWFVKPVTCESVRLCCGRVLEECLSLRNREYVVTKGYLKKVATTAEKLNKNQEQQRMSLSIMESLFKHSTSTTYKLIEFGVLDHILLTCKRATEAPATLRQAALALANLSLYSCPEAKKKIIQKKLPDWLFLLASQRDEATRYYACLAICVLGSCKEMEAAVQKSGTLSLVEPFLISHQPTTFADLDYKHSQGRPKEWLIRLLPLLRSKCREAKCMAAFHFCVEATIKKDQQKLEILQEIGATSALKEVASSPDEVAAKFASDALTIIGEAVPYKLTQQVPNWTPADVQYWVEKIGFGAYKEAFLSNMVDGDLLLLLTEKELEEDLGIPSGILRKRFMRELESLKIAADYSSVDESQLDQFLMSLSPELSVYTYQMLGMGLNRNFLPHLTNDMMKTVCGINNPVHRLKLRQALQDSKHIDDIEVAILSKQIDVFISYRRSTGNQLASLIKVLLQLRGYKVFIDVDKLYAGKFDSHLLKNIQAAKHFILVLTPNSLDRLLNDNNCEDWIHKELRCAFEHHKNVIPIFDQAFEFPEKTMELPDDIRQITRFNGVRWVHDYQEACIDKVERFIKGELNRMPSLGSTASLRNPSQTPSTTSTTVTRKNNYNLSRTKPSSSGAGTPSSTTTAPTVRVKTTTTTTHLEAHHPPISQQNSSSNSNNNNSSAINALAGRSASMEKQRRKLISSSVSTVCSGNSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZI5</accession>
    <name>A0A914YZI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZI5"/>
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        <property type="gene ID" value="PSU_v2.g551"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g551.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7496" checksum="2E9F59972ED76344" modified="2023-02-22" version="1">MDSNSLIPEEEGNDERPDEMLSAVGEEDPPRKKRGRPSNIITNTNEGSSGTNTNGVANTIDNTIDYICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z092</accession>
    <name>A0A914Z092_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MRG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z092"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5592.t1">
        <property type="protein sequence ID" value="PSU_v2.g5592.t1"/>
        <property type="gene ID" value="PSU_v2.g5592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5592.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="41701" checksum="2C92E8A085A58668" modified="2023-02-22" version="1">METFTNNNNYIRGCDIPFDKVMTIEALPVVTEQWLHDLRRHTGILCFCKKTVLYYEAKIEKIAGNGTGKTFKVHYKNYGKKQDQVFSFLEARSWFLPHTVQTITYMKKHNKDIVSLICEISLQEREMIVEEDDNDDDDDDEEDDDEEEEDEHVIQVKPKKTLPEMNVHCVESLGTLREIDDNGKLMTYYPPRYCMEEIVKNFQESTKMFDYFNEVTMDFFCSSFESSYMFSSRQTDADYEKNAAFLHYMGCCRSRGIHSPTQEEIDIKTQIFGQWKPNLACRYIFGVTHLVRYLIFLYQQQYDLESVRTLNGKEEEILLLVTHFAHFINQNREQYFCEEKDYTRPIVNFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0A1</accession>
    <name>A0A914Z0A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0A1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3705.t1">
        <property type="protein sequence ID" value="PSU_v2.g3705.t1"/>
        <property type="gene ID" value="PSU_v2.g3705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3705.t1"/>
        </source>
    </evidence>
    <sequence length="466" mass="54604" checksum="94B9800C35F4F779" modified="2023-02-22" version="1">MIPASLLLIGFLILFYNYFWKRRELPPGPLPLPIFGNIREIKNNPPGYDAYRNWRDIYGPVFTYWIGEKPLVAIADYNTMKETLIDDGDSYINRDFFNDFMIILRNNTFGLTSFEGEEWVEQRKFAIKTFHRLGMGKNVMQEKMFIELSRMFEDMDEEIKVTGSNDMNVAPFIETCVASIIYSILFDYQITRERKSDYMKMKTIVYEYTGLFGHWAVQMIMAKPYLFKDLPFFKDYMQKIHKAYWKMSEHVEMMAADAIKNYKMDMDSEANDYVTAFMRQHDATEEKKGYNLGNLNSILVDFYIAGQDTTINSIMWGIIYLMYEPEVIGKMQKEMDDKLGDEEFVGIDDKIKLPYTTAVTHELQRMANVMPQNIARRTTKDVVIGGYKIKEGTTIMPLMSAVLFFPDHLKFDPTRFLSPDEKSVIKVDELIPFSCGRRMCLGAEMAKMEIFLIVANLFRHYDVCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0C4</accession>
    <name>A0A914Z0C4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0C4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5332.t1">
        <property type="protein sequence ID" value="PSU_v2.g5332.t1"/>
        <property type="gene ID" value="PSU_v2.g5332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5332.t1"/>
        </source>
    </evidence>
    <sequence length="683" mass="78672" checksum="AB800FF0BEA012D6" modified="2023-02-22" version="1">MGNVQTAPIPRVIPPLEFYFQDVQEVKYSQNLGNTRFMKVAKVEHYDGPMVAKVFVFPDTFISDKFIREIRKIRKKISNSNYTNCLGFTKIFMNDKVAILCRPFHKDTLYERLSIRPFLIDVEKRWIAFQLLKALEQCKRVDVVHGDIKSHNILISSSNWVYLTDFASFKPTYIPCDTPSSFTFFFNASRQNMCNVAPERFKLSKDYDNFNTELPVYFHDLTKNRKEEMDIFSVGCVLLELFTDGRRYAFNFAKLIDYCSMDDDTAREYIDSIVTNCDSTIPEEFQKLIKSKPFQNHELFPPIFESFLYQYMGEFRVKASLSHGGEHSDEHVVPDLPDNVITKLYVERQRFMQEIEKDNQNSVILLITLITSNIRACRTIIAKMDAISLLKELSKITTEALIAERIVPYLVRLLSDPFVQVQTEAVHVLTEIISNFKHIPVEESRLFVDYIFPKMKELISNSATSPMTKMAIASNLGILALTALKFLDEGIKHATDEGGVIGSGVEQNVKNEKQATAIKTNQTPAAKLPNIERNSLNQTISEFYQQLITQDNNAVRQTVMEAENLDKLGRFFELVGTKINVVLMHMITVLNNKKDWRLITSFFKNSSIAARKSSKSDNSGFFFPLLQQGLQHNEEFVVLESLRCIYVLCSEQRLEKATVWELCKEFVPFIVHPLVKGMSVWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0W8</accession>
    <name>A0A914Z0W8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0W8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3916.t1">
        <property type="protein sequence ID" value="PSU_v2.g3916.t1"/>
        <property type="gene ID" value="PSU_v2.g3916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3916.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="34132" checksum="22BA332D14756F30" modified="2023-02-22" version="1">MQVHTATFLASSISGVTLIACLFVIGNIYADVQSIWNELDTEISQFRSNTDDLWRDMMRVSATKKRFRRQDYENAGGSSSHPSGSSGGSSGGSGPSGPQGSGPSGGSSSSGSAPGTPSGAAPPSVPPALSSGGNAGGSGCQCQAENNKCPAGPPGPKGTPGRPGPDGQNGLDGIAGVDAEDVTPADSGASGCFNCPAGPQGPPGPIGRPGMRGLAGARGMNGHEGRPGHPGTSGEQGPPGPPGPIGLPGPAGEKGRDAQKLIGRPGPKGPRGAPGPVGPAGAPGSDAAAGEAGPQGPQGGPGPQGPQGDQGPEGEAGNDGRPGRDANYCPCPTRNADARGGGAGGSNGGPYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z105</accession>
    <name>A0A914Z105_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z105"/>
    <dbReference type="WBParaSite" id="PSU_v2.g604.t1">
        <property type="protein sequence ID" value="PSU_v2.g604.t1"/>
        <property type="gene ID" value="PSU_v2.g604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g604.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36440" checksum="0FD38D6165D17270" modified="2023-02-22" version="1">MSIPWIEKYRPKTLNDVVGNTETIERLKEFSHLGYIPSVIISGPPGCGKTTSIWALARDMLGNYAKEAVLELNASDDRGIDTVRNRIKGFAQKKVTLPDGKHKIIILDEADSMTEGAQQALRRIMEIYSNTTRFAFACNQSDKIIEPLQSRCALVKYSKLSDEQMAKRVIEIAKIENLNFTEDGIEAILFTAQGDMRQALNNLQCTASGYGLVNAENVYKVCDEPHPDLMRELFENCAQGEFKDAFAGLDKLYKMGYSTDDILTTMSRVVKYIDVPEALKLEFIKEVAKTHTLAVQGMTGRVQLAGLAARLSKKQRELSEASENDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z146</accession>
    <name>A0A914Z146_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MYND-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z146"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6446.t1">
        <property type="protein sequence ID" value="PSU_v2.g6446.t1"/>
        <property type="gene ID" value="PSU_v2.g6446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6446.t1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40752" checksum="6BD750FF66198E8A" modified="2023-02-22" version="1">MAISRLIVDEDFDKAIALADTALEVLPQSTQFLYLRAIALCMKPSPECIKALDEFLAVAPKDHDKFPACHYRKASYYICVEQKLKFADSFKAGLESEKNQLPCFLPYQFPMKDLLMKFYAFGDIPVNIVENQSASNITSTPFSSSLENLMSNPQRKIMLLKNRELFLQLAARPNDKYNTVPKPANFPKPPRLASLKAITLKDINPTIDKMYDGYVLEVKIIDFSYLMVAINTVIEDENGDIQRLAVYNWPLKGDRKAEIAEAIKTFRPNVMVSIINPYMRLSSDMKNIIRVENPVYIRLDNTSADQKCTFCGKEAKVLPCSKCMMVRYCSKECQRIDWIEFKHKEMCEHLKNYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1B4</accession>
    <name>A0A914Z1B4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1B4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g568.t1">
        <property type="protein sequence ID" value="PSU_v2.g568.t1"/>
        <property type="gene ID" value="PSU_v2.g568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g568.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18591" checksum="B27189B3C879091E" modified="2023-02-22" version="1">MFLSQHALIKFTDKNISDFWFGANDLDSPQKWTWMDGTIFDFENWDKGQPADDDGNGCGAVQMHGGKWSAADCFLQKPYVCVFDTLNVTTAAALTTTTTSTTTTTTITTTTTPRPKPKSCPISWTYYNETGFCYIVFENEDWITAENRCKLQFIALKKRCFLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1H2</accession>
    <name>A0A914Z1H2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">E2K</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z1H2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5968.t1">
        <property type="protein sequence ID" value="PSU_v2.g5968.t1"/>
        <property type="gene ID" value="PSU_v2.g5968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="17">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5968.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="53578" checksum="63AC218B3C693A6D" modified="2023-02-22" version="1">MLRLSNRLQSSRLLFRQTRNYTRRLGVVIPQRGILLLQPQNIAPQARFIHASNVLFSEIIEVQGPAFAESISEGDIRWIKQKGDFVKEDELVAEIETDKTSVEVPAQFSGTIVELLVEDGARVTAKQKLYKLQKGGEASSSQSEKKDDAPTQGEKADAKTENAEAPVKGAPKAPEAGSSDASPPAKPKTESSERVDPPEQPHAKPGVSDIPPKLPKDLVKASKEPMLSTPVDKIQRTPISIPKGIPADQAITGSRSETRVKANRMRQRIAQRLKDAQNTYAMLTTFNEIDMTNVMEMRTRYQKDFMKKHGIKLGLMSPFVRAAAYAMTDQPIVNAVFDETEIVYRQFVDISIAVATPKGLVVPVLRNVEGMDYAKIELSLAELGEKARDGKLAVEDMEGGTFTISNGGVFGSMFGTPIINPPQSAILGMHGIFDRPVAINGKVEVRPMMYIALTYDHRLIDGREAVTFLKKIKSSVEDPRTILMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z219</accession>
    <name>A0A914Z219_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z219"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6139.t1">
        <property type="protein sequence ID" value="PSU_v2.g6139.t1"/>
        <property type="gene ID" value="PSU_v2.g6139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF3">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="2"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6139.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40030" checksum="DCAFA1B66C57E54E" modified="2023-02-22" version="1">MALSPHSRDLFHKVIQASGAALDEWASTAPVIKITKQIAQFMGCKSEDAKEIKAFLKKQKWEDIMDISSTKFDPNDKTKDNYIGFGPRLDDDFFAGKTVEQLIEEAPKKPTIMGLMTLEGGIFLLFGMKPEDIKTYSGKNITNAIKYRYAAECRAGKDAPGLQKDLIEYFVNRDAPTTPNPSFYLQRHGELASDLMFNQEVFKEADLKTKHGWPIYFYFWNHMSKEMYDSVGSIAKGAWHSYDLSYSFDQQVYPQDKKGDAEMKIQNYFADFFAQFAKTGNPKTDTIPFPKYTVDKQEALWIDPDLSVKSRVWEDRRKFWDNLSEKYDYSPLRGRTREQIKNRFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2E9</accession>
    <name>A0A914Z2E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2E9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6887.t1">
        <property type="protein sequence ID" value="PSU_v2.g6887.t1"/>
        <property type="gene ID" value="PSU_v2.g6887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF337">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="143"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="246"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6887.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38506" checksum="B0525C9FC10FAAF0" modified="2023-02-22" version="1">MSEEPLAAPEHAPLSLIVNHEPGEETKSPLQNSSSPKRTPKKFRRKKLHCFCLYFIGLITFTLIGGLIFWIVEENESQNYRTHFEQQCSEKRNELIAKFEAEFELIISKNQSINAKTLATLFNNSIDEFEQCMRDKIPEFAIPHVFDFLGSTMYAVTIFTTVGYGDLITRTNLGRILTIFYGLFGIPFYIAFISDFGDFLGKKFVKLGKCFRNLSLRLFIRYNLTAVEKRKPLSATFRFFFITLMLVLFVISITLLIQQCEKLYSKQWTFMDSLHFVFSTVSLIGFGDIIASHELYLALYLPLFIIGQALCALSFYFTQRFIRYMCLHKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3W5</accession>
    <name>A0A914Z3W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3W5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6698.t1">
        <property type="protein sequence ID" value="PSU_v2.g6698.t1"/>
        <property type="gene ID" value="PSU_v2.g6698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF17">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="48"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6698.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38969" checksum="D10E611FB0C6AFEE" modified="2023-02-22" version="1">MSAQNPCSNEYPMKNISNEITEGLEDEQPDGKFIISHRFRYFILILGVACLTSISSNLSALNFTFICMRKPLNETMLDVSFSNATNLPSKGDFMYTTNEKSALLWTAAIGSMIATFPFSYLYTQYGARYVFFIAGMISTISTLLVPYAANAGLYHLLALRFLLGVAYAADFAAIGILCSRWASLKQNAIFISFLTCFTPISSAITNPVSGILCESRFGWPAVYYVHAGASFILFIMWLYFYTDHPGKHRNVSMIEREKIHRNKSEAHINGDKYVPYWEIIKNPVILAVWLNAFVDLVSALFMLTYVPTYLNSVLHFDVKKTGWLAALPGLSHIPPKLLCGQLSDRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z418</accession>
    <name>A0A914Z418_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z418"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6746.t1">
        <property type="protein sequence ID" value="PSU_v2.g6746.t1"/>
        <property type="gene ID" value="PSU_v2.g6746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6746.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33976" checksum="BCF0910B379E5913" modified="2023-02-22" version="1">MPAPPLIVRKEKVVETTKTETELNVARILQNHLKEELKTPKTGEITQPPPKAEKSGVDKDVEKTVTIDEDVIPVAAEVTIEADEIEANVEHQTNVIEIPSDIHEPPSHSHETRPNSETTETDSHPNDSSSSTTTEEQPNRNKRVRSRTSRYIEFVVEEDEIVEEPVSKKNRKRKSILDQSPKNANLDDEYVPARRSKSGTRLPTTDEPCDPKIDYDCKIEGVEKIFDNVLEELLIEKIALTNACEIANTAIMAKSEKLKNECQKYIFENLRNNATLRNYVALNKEMKDEICAELAAKHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z438</accession>
    <name>A0A914Z438_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z438"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5022.t1">
        <property type="protein sequence ID" value="PSU_v2.g5022.t1"/>
        <property type="gene ID" value="PSU_v2.g5022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5022.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17036" checksum="8D31F14F04D6B18E" modified="2023-02-22" version="1">MLKKVGIENLVIQCGAGKVICSLVPEGLKNEDNGCFVEDDCGLKIEFFRYKKSIQENMQSATLIIGHAGAGTCLESLKLRKPMITVVNDKLMDNHQTELADRLAELGHLICTTPSQLHKAVTNKNLLSPKVFQPAKPNLFANYLYSKLGYVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z474</accession>
    <name>A0A914Z474_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PSP proline-rich domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z474"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7498.t1">
        <property type="protein sequence ID" value="PSU_v2.g7498.t1"/>
        <property type="gene ID" value="PSU_v2.g7498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="7">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7498.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="56965" checksum="F582D7AA741EC512" modified="2023-02-22" version="1">MPKRTSRLPPPPPPPIITIDDDEKPKEDGELSDEDSREAKPIPYRIKSKKKEENIPDTPAEGSDIEVIGDNLYDIDDNGCDDDGLDITMNIDDDEVFKKMQKAAGINNDDIDISINITETPKATRGQGTCFNCGGPHTLAECTAPHDRRRINRNRQSFGSTRRERITEHIESKFTPGQLSDEAKKALNLYDEEYPQWIMRMRDMGPFQGYPPGYLKRFKPSDKRLSFFCDDPHLTNETVKAEVEFDPEKIVYYDGFNLIDKRSEAERYCNQNVRKELQWKKWNKHSYPIEFEKFLKTSIIEDKAAESRKRQHGFDNNEQYSSKRDKEKERKREKRAAARKVEKENKKWQNYKLDLAKEKLVEDFKNTDISKEPEKIYMVDETFGIFESKRQRKKIDRERRRSAGSLEAEANWVKTMEEETWAAKEAKAIREELAKQEKAEKKSLPKTLKEKGAEKFAKKKAEREERDKRRLKIEKHMIEVGTQTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4F0</accession>
    <name>A0A914Z4F0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4F0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6872.t1">
        <property type="protein sequence ID" value="PSU_v2.g6872.t1"/>
        <property type="gene ID" value="PSU_v2.g6872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6872.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13251" checksum="AFDDC5DA2382B740" modified="2023-02-22" version="1">MGIKIFGGHLASISNAFTNAFIAQQAGYLLQGSGTPDAWLGGTSLIDATNWTWTDHQPFTFANWANSSAVKEHTCTAIGLANGLWMSDDCFETKPYICLIDSNVATTTTTLPQTTTPTPTFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4V6</accession>
    <name>A0A914Z4V6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4V6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g739.t1">
        <property type="protein sequence ID" value="PSU_v2.g739.t1"/>
        <property type="gene ID" value="PSU_v2.g739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036697348" evidence="1">
        <location>
            <begin position="26"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g739.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22387" checksum="150BE9D4E5130FF7" modified="2023-02-22" version="1">MFAMNGRLLLLLFILPLLYILNIDAADIKKIPFYLIPVLSLDGKTTDTGECIGTLITLEHILAPAECLKVKTKIASGVFIDFRAEKKYPENKDLFPITEYTFSKKIVLDPTSKLAIITLHVPFLQGNSLNIEKTLITPKVAGSTVHFERNKQLVNLVDGTGKVASATYSHDGTLVSLSAAAGPISIDKALCNWITKIANTVECKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6C5</accession>
    <name>A0A914Z6C5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHK kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6C5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7881.t1">
        <property type="protein sequence ID" value="PSU_v2.g7881.t1"/>
        <property type="gene ID" value="PSU_v2.g7881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7881.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27307" checksum="57864F8A7162FDA2" modified="2023-02-22" version="1">MDPNTKIAGTSLLLKPMLELLEQKHPYYRRLTNLGKSVTSFDVTNVSTGFGHGSIVYKINLHFTCHSGLPPETLPVALKVPGAEIYLQQESKFRTILPDNLEERISQEISNVHKTECLFYREISPTLNIKMPKIYATKEWIVGKEQGYILMDDLSEEGIVLSKYDSVSPGQIKAVVKEIAHIHAEYIKAGKSDKWKNVYGKNQEVWAGMTDEFLQLIPAFIDLVSNKDKSNLKKIVLLKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6P3</accession>
    <name>A0A914Z6P3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6P3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8004.t1">
        <property type="protein sequence ID" value="PSU_v2.g8004.t1"/>
        <property type="gene ID" value="PSU_v2.g8004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="374"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8004.t1"/>
        </source>
    </evidence>
    <sequence length="715" mass="81164" checksum="F4ED6780772C63F4" modified="2023-02-22" version="1">MSPTNRSPRKAKVKALNELNTPKKKQNISKISTPLAVKFDKLSIKSPSTRKGCAISPSNGSDKENYQNERIVNVKKKQQKVNGRKRLPLEELNKDEILFAPRSNVDGDISVIPQKQPLSTFSSEQNHEKMDSEDESCYSKPEISLTLRKNLRASEKPVAVEEKTESWTIESKSPLKLILRRSSSRSKTPEIKKLLPLKIFGLEKEYDSGDEMLKKNYQGLEEEYDSGEEKFSNNLHGLEEEYDSGDDDLKGICCYGIEQEYEESDDSDESSFLFGNRIAAPLKTNTVETFKEEPDTAEINLLIKAVSTLELDVMQEDALADAEMKHKHERNPLMKIYPLFHTSALPDVLLKRENQCKEIEKFIKQAVASNSSVHNRTIYISGVPGTGKTACVTKVIQKVQSQKKPIIKFSYVYVNGLEMIKPEHVFVEIYKVLYPSSSSSSTRSISSKTAREKLSKLFTFDDSKRLPILLVIDELDMLCTKSQDVIYDIFDWASTSEARISVIAIANTLDLPERVLKQRVSSRMGYNRLIFEPYTFDEISHILEYRIKKSGVSFNKGAFGFISRKVASVSGDLRKALEFIRRSIEIAVNKDSKTLELEHATAAVKEGLQSLPILFTKSLSLHQEFLLRAIIQEIRATSLEELDFFLLYECYRRNCLALVKEPMEMCAATALLSSLQTIGYIIVKSNGLISRRISLKISADEIEFLLKQMKITEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7F6</accession>
    <name>A0A914Z7F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vesicle transport protein GOT1B</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7F6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8618.t1">
        <property type="protein sequence ID" value="PSU_v2.g8618.t1"/>
        <property type="gene ID" value="PSU_v2.g8618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8618.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15350" checksum="CD3E62B00C21CB2F" modified="2023-02-22" version="1">MNFEISNTKQIGIGLSVFGVTFVGLGIILFFDGALLAIGNLLFIAGITLVIGVQRATLFFFQWHKAKGSALFFGGIIILLLGWPFIGMIIESWGFVLLFGGFVPTVINFIRQLPIVGNLLLLPGIRQCLDRIAPEHKYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7V8</accession>
    <name>A0A914Z7V8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7V8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7983.t1">
        <property type="protein sequence ID" value="PSU_v2.g7983.t1"/>
        <property type="gene ID" value="PSU_v2.g7983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF326">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER SNF-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7983.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57076" checksum="23064D42D12E002D" modified="2023-02-22" version="1">MAVLSLLVSVYYNVIVSWVLVFIVSIFMGQSRQWALCGNAWNDQNCLSSLGNKECAESLNDLEAFWFNGTCHNSSAFKELQQFMVNNQSATTQFFENWILQKSDRIENLDGINWPVFGALIFVWILTALALSKGVKLIGKLAYFTATIPYIIIAILFVRSVTLPGAKQGLDFYLLKIDISKIYDIQPWQKAATQVCYSLAIGFGGLLSLASYNPRSHNCFRDALIITVADGFMSVFGGTAVFSILGFMAEQQKKDITQVVQSGTGLAFIAYPEAMNQIPYVPWLWAFLFFFMLFILGGFKGGGLFFLQDPENQDAPATQSASLALCVLVFLELILVCYVYGIRNYIKDLHSMFGYPTTLFGKIFGKTGWYFIIIWSIVAPICILILLGYMIHELIETPLKYGSYEFPGPSMISAWILSLLPLLALPVVLIANCIHFRAIKKPLKELAIVREDWALSAHDPKSSTSSSDLEDPQTSPTTTSNVYKIRPIEISPSTLSDAWHSSTVTARPGKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7W6</accession>
    <name>A0A914Z7W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7W6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g878.t1">
        <property type="protein sequence ID" value="PSU_v2.g878.t1"/>
        <property type="gene ID" value="PSU_v2.g878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42929:SF5">
        <property type="entry name" value="ABC TRANSPORTER PERMEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42929">
        <property type="entry name" value="INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCU-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g878.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20633" checksum="6C0C35DE4FEA60C4" modified="2023-02-22" version="1">MRAPWRSIFLLVIIGPLLVSVVVRTFGWSMILGRNGFVNGALTMVGLEPVQLLYTETAIVVGLVHIMLPFMVIPVWTVLQKLDPTVEAAALTLGASRFTALRRIVFPQAMLGILSGSLIVFALSASSFAIPGLLGGRRLKMAATVVYDEFMIELNWPLGAAIAIIVLVANLVIMIAYNRMIEGQAKRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8N5</accession>
    <name>A0A914Z8N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <location evidence="1">Membrane</location>
        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B561"/>
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    </dbReference>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="8">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8205.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19370" checksum="3AA90394BC92C170" modified="2023-02-22" version="1">MVLFYLAPDVQPFGIRIWYHAHRIFNLTAAALMIFGLTTILIAHEWRWLGPKVGGGSKNTSATAYHSICGLLSVIIAWLQPFNALLRCTPSNPHRIYFNWFHRIFGAIGWILAAITIVLACNNFGKHFTDSQAALSLCSSFLGFCGASFIIAEIFKIVNSRKSEISMNNNNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAW8</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8907.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="21089" checksum="9927AE704BD8EA6A" modified="2023-02-22" version="1">MEEYFFKMTKNLFELQRQIDKRMLHLSHGKKATPLFNEDSEEDGGEMKIGENEKLKNNGWHQISHIMEDMGKDQAKYLKTGINENIFEECKWIELNEDEKYWLQRELQIQKQKVDQNENELKKIVNETKALTKEFLNVIEETETLLKKYAKIECKNMTTDLRNARLQILAAATKYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB85</accession>
    <name>A0A914ZB85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phytanoyl-CoA hydroxylase-interacting protein-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB85"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9917.t1">
        <property type="protein sequence ID" value="PSU_v2.g9917.t1"/>
        <property type="gene ID" value="PSU_v2.g9917"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PHYHIP/PHYHIPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045545">
        <property type="entry name" value="PHYIP/PHIPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15698:SF4">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15698">
        <property type="entry name" value="PROTEIN CBG15099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19281">
        <property type="entry name" value="PHYHIP_C"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="213"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF19281"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9917.t1"/>
        </source>
    </evidence>
    <sequence length="556" mass="63730" checksum="7058A14932CE43B0" modified="2023-02-22" version="1">MWNDETWKPWAQQDLHYRPIHPVHRSALAPPYALSSSSRPPLPSSSFHPYGRPDRGAPYANPSYFNELNPPAPYQRNPASRPDYWTPRALPPIVPLKTPHIELWKDFGAPAKPLEVILYARKSAKECSVRWQKPALAPQLAQSHVIKVFENEKLLDTAEIDRNTNEYFFKTQPGLFYTCEFRIKDARGIDTAEGTIRLRATFSFDEMEELLRKALDHVCVSRPQMHPFRILYRCKPQCYWDDIQVRSENVMRKYIKDDNGQAANPTNGMIFGLFFSARLLANGTLPPSSPFGNVRMSLPAEVLLDPERINMYFSDFYCNRLTHYVTVVICIKGSRTDAFCMDKLVPIAPSNPFVKIVFGPRGYEFYVNKTVWVEIYYTENVPLCWGKFDRVTATGLGTSRLGGLPHNKTCTVCNLYPIGKKGTTQLDEGTYEEDQNEIVAQQHLEKMITSMRNTELSTQECEDIVFLVSDLVDQIAYDNDVSFTVQKDGSIFGNESLPVENALNMLDEESIDEHPATKEITSKIRCLHEAVINRLDRVQSLINRSRKNIIKKIFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC05</accession>
    <name>A0A914ZC05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZC05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9265.t1">
        <property type="protein sequence ID" value="PSU_v2.g9265.t1"/>
        <property type="gene ID" value="PSU_v2.g9265"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000158">
        <property type="entry name" value="La ribonucleoprotein domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF166">
        <property type="entry name" value="LUPUS LA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08777">
        <property type="entry name" value="RRM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="106"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="XRRM" evidence="7">
        <location>
            <begin position="223"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9265.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38554" checksum="4297F49F207080EF" modified="2023-02-22" version="1">MSSNGQEMDLNDKILKQLEYYFGDVNLQRDKFLQDEMKKDHGWVPLDVLLTFNRLKQLTTDKVAIVAAIKDSEVVDVSEDGEKVRRNPAVPIPENSLEFWQEVKTRTVYVKGFPPETTLDDIMEYLKPHGTIVNVVMRRLKESRAFKGSIFATFKDKEAAEKFVKSEDTLKYKDTEVTRMLQNDYWAKEVAENKERKAAEKALKNQMKNETRKKTDDAHSAVHFVKGQVMRVSGLPTENVGFSVLKDFFNKYAPVAYAVYEQGSSEASLRFLSTEENAAVKALEKMNEAAKESDGKILFQSQEIECKVIEGEEEEKYWADFTKNKAEKEARGYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XR62</accession>
    <name>A0A914XR62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XR62"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10485.t1">
        <property type="protein sequence ID" value="PSU_v2.g10485.t1"/>
        <property type="gene ID" value="PSU_v2.g10485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10485.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19024" checksum="2126E0B231E40F1B" modified="2023-02-22" version="1">MSYRPQLTGGTPGWNDPPPPPTDALTSSGKINLALRRHVARPVDPSIQGGNTYAGPPQQGGPMGGGMSHQPYNAGQQATHQGYNPQMQQQQQQPAFSANPQYQQQQSFNQMPQQPSQQQYSPGTQQQQPYYPNSQAQQQPYSQQQQPYNPSMQAPQQQQQYAGQQYPGQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRJ1</accession>
    <name>A0A914XRJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MESD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XRJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10611.t1">
        <property type="protein sequence ID" value="PSU_v2.g10611.t1"/>
        <property type="gene ID" value="PSU_v2.g10611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019330">
        <property type="entry name" value="MESD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600:SF2">
        <property type="entry name" value="LRP CHAPERONE MESD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600">
        <property type="entry name" value="MESODERM DEVELOPMENT CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10185">
        <property type="entry name" value="Mesd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10611.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12474" checksum="CF1119ED9A06FBAE" modified="2023-02-22" version="1">MLKNAQSPEDVLAASKRGQPVMMFVSIANPSGEAVTKQFSEKVSQFWQSSLFNNHIDVQVYPVEDSRILFMFKEGSQAFEARNFIIKQKECIEITLEGKSMIGAGGRKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTX8</accession>
    <name>A0A914XTX8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bystin</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTX8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11412.t1">
        <property type="protein sequence ID" value="PSU_v2.g11412.t1"/>
        <property type="gene ID" value="PSU_v2.g11412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11412.t1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40251" checksum="EF8B572668058301" modified="2023-02-22" version="1">MNRRKRLLGKAGGKVEKPNAPIDIQMRDAKLAKVKHLEIHEADVEDDDGSMPIKPKRLSKALRVAQKQAEVAGSDTESEDEPALKKGRAISLSNLNEEESDVDEDEEEVDFDPNDVVVDKDVEKDLEKFLEPGEGGTIYDLIRQKIIEKNNPNLIPLGAPQDSNIPPEAIRLYNEVGNILSRYRTGKIPIAFKNLGTLNNWEQLIEYTHPESWTAAALLYATKMFVSNQKPHRCQRFLNTYLLPRLRDEIAAHKKLSPHLYECVFKSCFRPSAFYKGIVLPLAESGSCTLTESVIIGSVILKRHIPAIHSCAAIYRLACMKTNNFASGLYFMQVLLRKKYALPYQVVDKLVEFFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTZ3</accession>
    <name>A0A914XTZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10442.t1">
        <property type="protein sequence ID" value="PSU_v2.g10442.t1"/>
        <property type="gene ID" value="PSU_v2.g10442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10442.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12894" checksum="460A3CE9C1EEE8DC" modified="2023-02-22" version="1">MMHSSMAASNEGSKDKAKTNMRKHLVKKRLIQEYGLEPTVDIGTSSRCHISLDDNGFNDRRKSQSLDPEDWQRQVALASGEEDDDETSPRNNERKKSAFQKMRNKLAKWRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU70</accession>
    <name>A0A914XU70_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XU70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10083.t1">
        <property type="protein sequence ID" value="PSU_v2.g10083.t1"/>
        <property type="gene ID" value="PSU_v2.g10083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000019">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10083.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27438" checksum="2D20B34492877CA7" modified="2023-02-22" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAVKLGSTSLGIRTKEGVILAAEKRANSKLMVNDAIEKISKIDQHIGVTFAGLIADSRTLVERAQVESQNFWFTYNRKIRVEDVTQSVANLALQFGDDDVKASMSRPFGVAMLFAGIDQNGPQLFHLDPSGTFIDCQAKSIGAASDGAEQNLKEQFHDNMTLREALKVAMTILKQVMEDKLTSNNIEIVTITPTTDKNGKLTGEFKRLTNDELQALVGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVD7</accession>
    <name>A0A914XVD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10938.t1">
        <property type="protein sequence ID" value="PSU_v2.g10938.t1"/>
        <property type="gene ID" value="PSU_v2.g10938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10938.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24439" checksum="97EAA93F985B56C5" modified="2023-02-22" version="1">MDFTVAIGIIFMLISFVGIIGNIVVLFVIAVNKQLHDNTNLLIANLALADFLFLTLCPPISAYAYVYGWQFSATLCYITVSFQYITCYVSVWTLGLLAYDRYLSISSPTVVKSLRRRCTVLYACALSWILPFLINLPQMRNVGVLEFEYDGKYGMVCVDSLTIATESSTVASARIFYWGFNVFAYLLPLSLCIIFYLLLVKKIWKQKIVTSKTSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVM4</accession>
    <name>A0A914XVM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVM4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11023.t1">
        <property type="protein sequence ID" value="PSU_v2.g11023.t1"/>
        <property type="gene ID" value="PSU_v2.g11023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="61"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11023.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46781" checksum="2423905799253B09" modified="2023-02-22" version="1">MIAEEDKQEECTETDMISPESESEAAKKQTNNFDTPKRSRKRRITIAPEEYSPNHKIMYTVKILLPSELKMYPSQQIAMGKVIQALNKKQNVLIESPTGSGKTMALLASSCAWLQRHKLQQICLQHPSDADNSGIQNDNNNIVPKTDVSTDMKCTCIEKKKIQIYYATRTHTQISQVIKEFERLPYGRESGDKQLRHTILASREQSCVNVELREHAIKEVKDLKEACKEATDLRNCKYRNNLFKKYEDPRQPNELRKQIDGSKIDGSSSIWDIEDIAETLKNLELCPYYATNRLLIDDADIIFTPFNYLINQTIRNSSRIDLENSIVILDEAHNVENICRDSASFSFKETEFHVALKFLNILIWKIVKELEKMSENPSIEKDILLEQKRILQKVSILTMFFSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXA0</accession>
    <name>A0A914XXA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10373.t1">
        <property type="protein sequence ID" value="PSU_v2.g10373.t1"/>
        <property type="gene ID" value="PSU_v2.g10373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10373.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17333" checksum="DCCAAB34FCAC6DD4" modified="2023-02-22" version="1">MKKRREIQRRVQERAKNVKESVHSRQQHESANHRIITGNNNNNDFSQRLRRLSPAFFTWSRRTSGADSTTPSLTLHETTFREPQTSLNVWQSRESPKPPKVVKLEPLQAKTLHRRAGGAPLAFDEIEIGGGQHNVSRKSTDGLLRLPHSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXM9</accession>
    <name>A0A914XXM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF148 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11965.t1">
        <property type="protein sequence ID" value="PSU_v2.g11965.t1"/>
        <property type="gene ID" value="PSU_v2.g11965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037617377" evidence="1">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11965.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24159" checksum="A0DEF54F9F3970A3" modified="2023-02-22" version="1">MMKKIVLIFFGYFIFNLIAAEEVPNFLAGLDQNKTMAFYAIESGLNLSKNDIVQRKAEWAASLPPENRIAFEKFNNLANQAKSQLQNTNTVLNNNNQLSPEANAVKARIQNILNDGTLSRTGEVAAIENILSQNSPSIDAELIDGGGGDSSFLRNNANNVQQQNDQIIQSSIDNNLVNQQQLPRPRQQSQSQKPSFLSLGDLYRASASFAPQRASIFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYL0</accession>
    <name>A0A914XYL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12297.t1">
        <property type="protein sequence ID" value="PSU_v2.g12297.t1"/>
        <property type="gene ID" value="PSU_v2.g12297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12297.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12959" checksum="213DE2F5C9F1707C" modified="2023-02-22" version="1">MLDTVEHKTKIELFTLDLMVSSPFFDIIVLWKFMKDNAKNPPWTKKHYSGTTPAWFEINLKNANSETNFSRNGNTLFGYYRFAFSSHPYIIPHYDENEFFKNNVIQRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYU1</accession>
    <name>A0A914XYU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYU1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12118.t1">
        <property type="protein sequence ID" value="PSU_v2.g12118.t1"/>
        <property type="gene ID" value="PSU_v2.g12118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12118.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="45196" checksum="93FDFE811D22B107" modified="2023-02-22" version="1">MFSTFLRNTRVPFVFYFITIAAMIIYCFYISHQSSQGLSTFNSRFNEPLEAPIIDEKMLEKVKFQEIEKEESLIRLNDMDTIRKANADPLPVISDFGTDWKQPNWTENICSGEDEIKCGAKLKSLETRLRASPKYKTVACIIQKNMSTILQAIMCYLFDEASFVKAGRIISRECHNNRFCVKKNEFNAVYAATRVLNVTRTEMADWKYVAIVRDPIDRFLSGFVDKCIRKPNDLEYYCNNCGSNMTCFILTEYERIMRSSNGNVLSRTFEDRHFFPQNWRCNFRTELKHYQLIEYSSHPEHTNKFLNDLLEAFKQQHVPDESQKFIKDQLTGGRTVHTTVASDARIFLEKRLLSSPFLMEYIIRMFYWDFRLLGFKLPTFKPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ15</accession>
    <name>A0A914XZ15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13186.t1">
        <property type="protein sequence ID" value="PSU_v2.g13186.t1"/>
        <property type="gene ID" value="PSU_v2.g13186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13186.t1"/>
        </source>
    </evidence>
    <sequence length="515" mass="57457" checksum="08473CB02DCD7633" modified="2023-02-22" version="1">MNGPSPSTTPQKQQQLSQSQLQQHPSQQSSQFPHRPQASVVPFQIQKPMLNSSTDSEKITFDQLDHPPASGKRLPQRNIVIKRPDKPPPPPKRNSTTVAQYGNNGDIRMMHNGIERPMPPAYSTIANSTDYYKNFDQGALIHGRTDQLSLRNDSMKSLKRRSLLSQGDAPEVDIFRMLLEEQRKGKTHISFNDLHHELPPSSASSQSIQAPSSTTPTIPNTMNVNGVTVNLRSHVIQQPRQPPATMIIEESAAQTAQAAQMPVVASVKVSVSPQKSPIKETVIIKDYIETSINTDPSIAELEKPIEREIEIIKKEEPKVIIEAVTAVDNNNTSSIEVLTEEEEEHEDEEAQLKRELEQLSIRDQEASPLKESIETLPLANEMPQIPAIIEVEIHPETAVEEAEDNEEEQEVDVDFDHHLMHHHSIMHVDPSESSSSSVDEEGSNSSEIPIIVDESPSEDKAHLKGILRAPGKKKHNKRIIFDPFVLFLDGALEGQLDTVQENASKVYCSFEKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZC6</accession>
    <name>A0A914XZC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZC6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12568.t1">
        <property type="protein sequence ID" value="PSU_v2.g12568.t1"/>
        <property type="gene ID" value="PSU_v2.g12568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12568.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11439" checksum="6C8B9B59D6771579" modified="2023-02-22" version="1">MAFYLALFNVNHVNDEVKHSVSHARRSKSVKPVLKDKNRRHSLSSTQEVADYRLLPRPRIIGSSHNIRQLRRSPSPPPPNRRTSAADSTLCNCDRLPCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZF4</accession>
    <name>A0A914XZF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZF4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12593.t1">
        <property type="protein sequence ID" value="PSU_v2.g12593.t1"/>
        <property type="gene ID" value="PSU_v2.g12593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF134">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC1 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12593.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="26737" checksum="D07B02EE3585C5B4" modified="2023-02-22" version="1">MISERNTHLRILYREHIMVTNQFFYNHLFVDECKITSGHHGKFQWYRVNQFNPKRKRVAHYSGFSIYGGISRRGPTSFLIIPGNARINSEIYCDMIGHCVYPFIRDVYAMNCNLIQDNASIHVSHYTREFMDHLGIRRSFFPAQSPDFNPIEYVWRGMKEYVSQKNPTDLEQLQLRIAEYVRKYVTVEFCNQLIDYSRRNIIRSVDGRNYEGTKPTNLLYRDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZL8</accession>
    <name>A0A914XZL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZL8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13405.t1">
        <property type="protein sequence ID" value="PSU_v2.g13405.t1"/>
        <property type="gene ID" value="PSU_v2.g13405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="798"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="929"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13405.t1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="118896" checksum="4836A3F445E08D0D" modified="2023-02-22" version="1">MAAVTANSINLIQLEEALEVDSENLEQLQYWYEQLSEIELDGSESLETVELLFRALKWLIQYEHTNAEELKEIAEKEAVEMAEKEENWEQEKEILKEELSLLRERITSKAGTDDMNEAFRAEIDSLKAEINHLKQTGRDRDRELADRENKNEELAAKMEAFEKERTLLVQNQSQLEDTIRELNRRITSKSDSSDKDWEARKLKQRSEQAFILSNQLQNAVSQNDHLQIEVNRLSSALEAATILIKETTEKYGTLKEQLSNSEKTIEKLMDDNQNLKKQLALRQSDLVEKIETFELSAKEVEDLIKTKDNQIEKYKEVLNDQLMEIDEQRARLALVKNDEREAELERLRQELVDATKLARHLFGSMSGDMPHGQSLDPTAELRVRIVQLDKQLEMAAKNIIELKEENKKLEKIAEEKDEINAKINGELERIRKISFGDADEEIKHLERQMRFREEQIEELTTKCSLLQIELQKYDDDISPEKLAYAKIPHPPTVPKALSPPRRRGPIIKKPIQRPPTIISKPPPTKIIEIEEKDSEKEATPKREISEIYLNDVEASAMIISSLNYELMRVLQENEDKERQLKEFEKLTKDHTKDLHNARAKITLLISKYADLKAQSMISLDIGGRNEEESAKDSRLQELEIKVIELERLADSVKQNGSEIDRRMEEAARKLIYVQIKNSEYERKIENSERIQKSAVEMNERLRTKLRRLLTGENRKLKTLSRDYELSMIEIARLQNVIIHSIPLTQYEKILKAYKSLIHKSTVNGEYNAENDPAFENDHPISNISANFAITNDQSATIIENLSLKNLEIQEINEILESQNEFFRREFDRQQLEINELKAFLTDIENQTELKSLIVNIERRFLQGIQEQADSADEQYFSEKELRTITKKSMARKKAWKQERQNLVGIIVGLQNTVHRLKEQTTSVIRMDHLIQIKESAEKLKDKERSLKEKEEIIDKKLSDLSIRESFVESQAGAIKTVMDADYNLQRIQKSIQGYEFNVLALSNELKAAKNEVIIPCFWATEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0Y2</accession>
    <name>A0A914Y0Y2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0Y2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13108.t1">
        <property type="protein sequence ID" value="PSU_v2.g13108.t1"/>
        <property type="gene ID" value="PSU_v2.g13108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13108.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9276" checksum="49A156C5CBE74DBA" modified="2023-02-22" version="1">MNDEEASSYLVSLHKVLKTRDFIKHDHLHRTRVFENMLPEDPKNGCYMYDAIIGYSYAHPPVLAELKRITYDLVDTVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1F5</accession>
    <name>A0A914Y1F5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCDC92/74 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1F5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13054.t1">
        <property type="protein sequence ID" value="PSU_v2.g13054.t1"/>
        <property type="gene ID" value="PSU_v2.g13054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040370">
        <property type="entry name" value="CCDC74A/CCDC74B/CCDC92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039496">
        <property type="entry name" value="CCDC92/74_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882:SF1">
        <property type="entry name" value="CCDC92 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14916">
        <property type="entry name" value="CCDC92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC92/74 N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13054.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30101" checksum="17A6673B5DCD833B" modified="2023-02-22" version="1">MIEMETSAPLELQKAVHERDQMWKLHEKAQISFLQNQNTQMLSHLHTEIDRLMSINRELSRRLNVSNSSDKEEELERLLENEEQKNAELLEELQQNQKHTAVLEKTLEHTVVLYKDKLTQHEDRIRQLTGELHDRTQTVTQLSSQLRSIKLREAMAQAQQRRRASCSSPKSPTSPAVSPNECNSAFRLFGFAKDFARQAHLPSTQKTIRLDALPQPHWPDPMHKENNIEKPRTLSTSYITARPRHLASLRRAGSTSGDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y255</accession>
    <name>A0A914Y255_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y255"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12866.t1">
        <property type="protein sequence ID" value="PSU_v2.g12866.t1"/>
        <property type="gene ID" value="PSU_v2.g12866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12866.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="25225" checksum="A69DDD7EF7E6D169" modified="2023-02-22" version="1">MDGSRGSYPIVRAKSTMTLPRARDIERGERVGTLTRVTSVPNINSMYPETTYRPSTVFKYRRDWELLDDYWHDRYTYNPSVYWQDYRYAARRYASTDPIPNSLGFGYPAFWSRYKWYSDYLNPLFYRRYRDPYYDRPLYDSWRPYQFDRYSTKRAVKMFRQGLISFNTLDKKWIEPTALGRREKDWSDVYQPAGRYGARRYFYSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2W9</accession>
    <name>A0A914Y2W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c oxidase subunit Vb</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2W9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13794.t1">
        <property type="protein sequence ID" value="PSU_v2.g13794.t1"/>
        <property type="gene ID" value="PSU_v2.g13794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase subunit 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13794.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15134" checksum="633D7DF25A8828A5" modified="2023-02-22" version="1">MSSIIGRAAVFAKLAKNRSVSQVAAIAARAYATEASPEDYGYYPDPLEHATGREKKMLIARLAGDDRYEPKVYYRAEVSTREKPNLVPAHFDFRIVGCMCEPDSGHVNFMVVRKGLTQRCECGAWYKAIDADPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4B8</accession>
    <name>A0A914Y4B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4B8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15043.t1">
        <property type="protein sequence ID" value="PSU_v2.g15043.t1"/>
        <property type="gene ID" value="PSU_v2.g15043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15043.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15645" checksum="725C9A0AF2825087" modified="2023-02-22" version="1">MQINNNNILQRFHDPKEVVGKIFMDIVNDIAPELRKLFGVDRAPKATMLKMPKFGGHVSRMADFLEQMTSMLGFTENIVGAWQLARKTGRLHVKVGFLEENQNQLEKNYFTIVTDYFIGQFIGYVTGEKVCILLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y551</accession>
    <name>A0A914Y551_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arginine methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y551"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13899.t1">
        <property type="protein sequence ID" value="PSU_v2.g13899.t1"/>
        <property type="gene ID" value="PSU_v2.g13899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF4">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13899.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17549" checksum="8AB7DA2A310852DD" modified="2023-02-22" version="1">MAVRHGADKVTAVEVFDPMAITAEKVIRKNGHDDKVKVIHLRSTEIEENLVEQKADIIVAEVFDTELIGEGALRSFKEGLVTLGKENECRVVPAKGRIWICPVASEKLQQFWKLPNKRFKAPFDECPGTAAVFDIQLSEIDPNWFKVLAEPFVAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y582</accession>
    <name>A0A914Y582_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LTD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y582"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14597.t1">
        <property type="protein sequence ID" value="PSU_v2.g14597.t1"/>
        <property type="gene ID" value="PSU_v2.g14597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF6">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFB-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14597.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12471" checksum="BB48286190E5AEA4" modified="2023-02-22" version="1">MPIIYSVGLRQMVEQVVKTHSLQQQEDTDSTRNVRGEVQTKTTFQRSAKGNVTISECEPNGKFITLENTHRSKDEDISGCKIKRKLDSRQEISYTLPAGITLKAGRSTKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5R0</accession>
    <name>A0A914Y5R0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5R0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14580.t1">
        <property type="protein sequence ID" value="PSU_v2.g14580.t1"/>
        <property type="gene ID" value="PSU_v2.g14580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14580.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23976" checksum="566FEA42E9BFEDC1" modified="2023-02-22" version="1">MPRESIFRRTAIQSHARRRLFADDDIDHNELNQRLQSQLDEEVQSQSRRWGFDFHNDIPMQCDSNENPTTSSSTTSTETTFIYETLNANEVPVIYRSNTIVRKEIPRVGMVEIKHYTSGRGPIESPTKSIQPTKSAENTRKRRLPTPSTTPMKLRKRASPHKTPVNPGPKPHEHSTSSASKRPRRNLTEKFKASASAVPPHSTSSEEDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y620</accession>
    <name>A0A914Y620_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyprotein allergen nematode domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y620"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15642.t1">
        <property type="protein sequence ID" value="PSU_v2.g15642.t1"/>
        <property type="gene ID" value="PSU_v2.g15642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.30">
        <property type="entry name" value="Nematode polyprotein allergen ABA-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032487">
        <property type="entry name" value="ABA-1_nematode"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038289">
        <property type="entry name" value="DVA-1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16469">
        <property type="entry name" value="NPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="2">
        <location>
            <begin position="47"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Polyprotein allergen nematode" evidence="2">
        <location>
            <begin position="173"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15642.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34242" checksum="962F7BD100D39F29" modified="2023-02-22" version="1">MNGHQFFFGRYDINACAYLWNIDIPVETIGASARVRRSTTSQNVLSTEWLTDDQNAQLSGLENDEYDKKYLSFFKELSGETKNSASKKIVKKCYAWLEDVASQEERDELKTLHHSDHSKCKEKVQEYLEKLPETKKTEIKEHLDVCEEIWYAEHGGHEHGHAHHHRRRRHHEHSFEDFAKEHLGWLTDNQKAEAMKLKDDKAALKLKMKEFFEATAGEKRQEAISSMKGACRQLLKHVLGDEKAAELKTMKESGASSESLKTKFEEYMNGITDEHLKEEANDHKEECMKIPSSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y621</accession>
    <name>A0A914Y621_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y621"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1489.t1">
        <property type="protein sequence ID" value="PSU_v2.g1489.t1"/>
        <property type="gene ID" value="PSU_v2.g1489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="213"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1489.t1"/>
        </source>
    </evidence>
    <sequence length="605" mass="69574" checksum="AB8874FEB69DB11C" modified="2023-02-22" version="1">MDFLLDSFDTVDLIVLILFGSQTGTAEELAGRLAKDLVRYGKKALVMDPEEVDPEDFERIIEIKNPLLILCVATYGEGDPTDNAQQIYEHLQNAEPDFAGLRYAVFGLGNKTYEHYNAVGKFFDQRLEELGAERVFDIGLGDDDANLEEDFMRWREAFLPALAQSFGWEISNDGGLERQYRLEIIEEPTSNVFTGEYGRIGAYERQRPPFDQKNPYLSKIVDHKELHTSASERSCRHIEFNIEGSRIRYEAGDHLAVFPTNDSELVEKLGKLLDANLETVFKLINTDEESSKRHPFPCPCSFKTALTHYVDICAPLKSHVLKALVEYTSDEAQKEKLNLLSTASEDGLREYAQFIGKERRSIINILEHFNTCKPPIDYLLELLPRLQARYYSISSSPKVDPNIVSITAVITKYTIGDRLIKGVCTHYLSQLKTNDTTPIFVRKSTMRLPHRPNYPVIMIGPGTGFAPFRGFLQERSWQKSQGKEIGPIVLFYGCRHPEHDYIYQEEILKYKDEGVITDLGLAFSRYQDTKVYVQHLIWDKRERLWDLIQNNANIYVCGDARNMARDVQNTFLKVFQQIGGMEVEASQKFFKDLERQRRYQADVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y634</accession>
    <name>A0A914Y634_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">methionine adenosyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y634"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15657.t1">
        <property type="protein sequence ID" value="PSU_v2.g15657.t1"/>
        <property type="gene ID" value="PSU_v2.g15657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15657.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15955" checksum="DBA04A53FFC40A03" modified="2023-02-22" version="1">MLLKKLFLVDRSAAYGARWVAKSLVKAGVCRRCLVQVSYAIGISHPLSIMVISYGTSPLSEPELLSIVNDNFDLRPGVLIRDLGLKNPIYKETAKNGHFGHERFTWEQAKELKIRPEFATKLKTRALNLSQASGDASQKVNGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6L9</accession>
    <name>A0A914Y6L9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF2 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6L9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14902.t1">
        <property type="protein sequence ID" value="PSU_v2.g14902.t1"/>
        <property type="gene ID" value="PSU_v2.g14902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNF2 N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14902.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20824" checksum="8BEE1DEE714C9F79" modified="2023-02-22" version="1">MDLYQLINFASPGIFGTAETFRKKYSKFIEIGNNVDASIEERRGKAMVCHEIYQNSSAVIHRRNIEIIKEDLPKKEEFIVKCCLQDFQVQLYKAFLRALPTEKRSELSANHQLNRICCHPNVVGNYLRGKSNDTEDLSWYDNSIKKFKEKIVRNDVDHGSKVKLLIEVIRQCEELGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6P2</accession>
    <name>A0A914Y6P2_9BILA</name>
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        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6P2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14926.t1">
        <property type="protein sequence ID" value="PSU_v2.g14926.t1"/>
        <property type="gene ID" value="PSU_v2.g14926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="33"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14926.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32546" checksum="974B0DF576731055" modified="2023-02-22" version="1">MLERLAQLENNFSLLLSRGKIEPYASLGEALGAPSRFTQPINVKITDPIATPEENKEQCQMPFWRSRIIALYIDWAKTFFAFRKLPYADQKFGHTVALITNHASSYMIMCEAFRTPEHKKDVSPPPNFRTIIKQEVIDDEMDATTSTPNLNNVIQQQPSPPPLPPTSSTGTTLQRLKTPPPTATSHSSYFPSNMHTFFDPDLIREGKSCIETGVRSLVDVPPAVHYPTVGSLSGLTPVMAVMIDYVMKPFRRLKITTTEFATLQAIMFFDPGKIKQVFKAAFLNIFNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7F1</accession>
    <name>A0A914Y7F1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7F1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16133.t1">
        <property type="protein sequence ID" value="PSU_v2.g16133.t1"/>
        <property type="gene ID" value="PSU_v2.g16133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16133.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="12037" checksum="611C6847416E468A" modified="2023-02-22" version="1">MIFIYYFGGKISQKDDIIKEQFCQVDHDIELEKIVYDRQVDATIKKYDEHVAQVKDRVIGNLLDLVMDIKPEIHHNFKVRKEINETGTYTRIIDPLHSASRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7X0</accession>
    <name>A0A914Y7X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7X0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g163.t1">
        <property type="protein sequence ID" value="PSU_v2.g163.t1"/>
        <property type="gene ID" value="PSU_v2.g163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF208">
        <property type="entry name" value="ZINC_IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g163.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38702" checksum="E656534E9B79DB5A" modified="2023-02-22" version="1">MIIEFAAVSLSTAILIAASILPYITLKRGIDSPRIGRPKALNGLSLSNCFACGIFLGTCFLGLIPHVQMQEGVILKQLNISDPHSQEYPYLRTNFVILAGFLLILLIEQIAFICAPSSSHNTVLTDAHYHHPEQSSAPRQNNGLSEGDINQPLVDLDSESDQDDLEEIQFRTVVPSHHQHLHDHSDDEHEHGHHHHILPGETGSIEYILLLIALSVHSIFEGIALGAQQELNGFMKFLLSVMVHEVLCSFAYGVSLSKQRIPLKKALGSILFLSFSLPIGILVMAWIGTFEALTALIFRFVLEGIAAGIFIYVASIEMLSAEIPHLPSKAGFVKAFVVVIGAAAFFFINLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y823</accession>
    <name>A0A914Y823_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y823"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15424.t1">
        <property type="protein sequence ID" value="PSU_v2.g15424.t1"/>
        <property type="gene ID" value="PSU_v2.g15424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF39">
        <property type="entry name" value="PROTEIN CBG14679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15424.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11245" checksum="0875CD52ECB1B9D3" modified="2023-02-22" version="1">MMTASVSLIHDHGYYMVVDTPSATDLPAKEQMLRGFNAANLFPGQVQMVLTTHGHPDHTGQANFFPNSRHFFASYEYTGNNYIKTELYTVGICFCVIFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9D4</accession>
    <name>A0A914Y9D4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y9D4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16050.t1">
        <property type="protein sequence ID" value="PSU_v2.g16050.t1"/>
        <property type="gene ID" value="PSU_v2.g16050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF495">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16050.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14748" checksum="0D3A7F87A59FB3C2" modified="2023-02-22" version="1">MDGFFMVSLIRDIAEGISFLHNSSLFHYHGEISSRTCLIDERWQVKITLYGLYPFHYYERKDPENLLWCAPEIIRSDGEIYGSAAADIYSFAITASEIVTQKPVWNLGESELDPEGEYNIIYNQAILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9H7</accession>
    <name>A0A914Y9H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9H7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16093.t1">
        <property type="protein sequence ID" value="PSU_v2.g16093.t1"/>
        <property type="gene ID" value="PSU_v2.g16093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14776">
        <property type="entry name" value="UNC-79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16093.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17136" checksum="7DE98BC619129ECA" modified="2023-02-22" version="1">MCAWETIIERDMIEAIVKLLKETSCQLEGTEGEGKRPKWLRQLEGGQSLGRDIDSMADEKRMLSRYGIWLMAAMCPPSIEAPSHAVGYMMSMVFQWFTTTALLPNDSMGSSLEQLKTDFASEWVNQAINNHYDTFVLTLMPHVPEYAQVGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9S0</accession>
    <name>A0A914Y9S0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y9S0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16180.t1">
        <property type="protein sequence ID" value="PSU_v2.g16180.t1"/>
        <property type="gene ID" value="PSU_v2.g16180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="7">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16180.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23356" checksum="748472257803B97B" modified="2023-02-22" version="1">MSSSSSPTSSLISETQPPRQMNLIVAIDAENGISKDNSLPWHLPKEYKHFQETTIKTSDPSKINAVIMGRKCWDSIPAKFRPLKSRINVILSKTLPPQLSEHCIITDDFDKALKMLTEEEPYKSKIETIWNVGGNAIYKWGLEHPWMHKLVITKIEATFETDVQFPEIDWENYELNDDFDGKPIEEKGLTYRIQSFTKKRSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB09</accession>
    <name>A0A914YB09_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination. Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 14">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YB09"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17395.t1">
        <property type="protein sequence ID" value="PSU_v2.g17395.t1"/>
        <property type="gene ID" value="PSU_v2.g17395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
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    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
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            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044007"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00054653"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17395.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12541" checksum="AD9348EEFC66F9C5" modified="2023-02-22" version="1">MLLFCPTCGRLVTLEEGFKQFKFVCDACNFKMPVSGEIRSRLYPKLKNVDDILGGVNVWANAQQTTERCPKCSHERAYFFQIQTRSADEPMTIFYRCANIECGNRWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB97</accession>
    <name>A0A914YB97_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Panagrolaimidae</taxon>
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    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16556.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39036" checksum="DB8A501A8BBEDDEF" modified="2023-02-22" version="1">MVAEQKEAQMKKTFAKLMINDTENNDFSALILNEIELKVAEFKAKEAQTWKAYTDLINYLRNDPFYSRLKDPTELGTREHGVKFLTSVIISSCLIQQNIPPTYPPPHSTYQQSSPPNSSFSCSPADLFRYRFEEARQIMNNFAGFHIAQQAIILSQIAYATGNWTLEQKQQYDNAHLNHHFTTTGTSCSPFPDVSMIRHLLQPVFPPPLPSNPFKNNPVPRGFLTNALAQQSLKSSHTVASQDSYVKTFTSAGFPNQTSASHQPPLNQHSNFNVLSTSQNSTVNADTHSTNKPTSSANFFPSLISAQTDGKETGAAYEMTNTSKTVNEAFRLAFEHWRGISADTPEVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBI8</accession>
    <name>A0A914YBI8_9BILA</name>
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        <submittedName>
            <fullName evidence="3">JmjC domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g1613"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin_8"/>
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        <property type="entry name" value="JmjC_dom"/>
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        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1613.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17383" checksum="A0B2DF4481D42EAF" modified="2023-02-22" version="1">MSTGLDSPKAYLAQHALLDQLNLLDSVPIPDYASLLPSEADPLVNVFIGPSGTISPLHFDPRPNFFCQIRGRKFVRLINPKYQEDVYLNPDPMYANSSIADFENLDFLKYPRLKEVEMEDVILEEGECLYMPQKYFHLMRSLSPSISVSIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC03</accession>
    <name>A0A914YC03_9BILA</name>
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        <submittedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g17736.t1"/>
        <property type="gene ID" value="PSU_v2.g17736"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00013">
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    </dbReference>
    <dbReference type="SMART" id="SM00322">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="13"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17736.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15095" checksum="DEB7594B41011EA5" modified="2023-02-22" version="1">MSSELTAFFFPSVFQEKTIGIPDHLCGYIIGTKGRTIKEMQERHGVKLILLDETILVTKKYSDGIHFRQLGKPLKIIGSPEKIEAVLVEIEKMLKHGGLPGIEPTGWFASDEKMRRLMNDAPPNNSAKKLINEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDG0</accession>
    <name>A0A914YDG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uroporphyrinogen-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDG0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16784.t1">
        <property type="protein sequence ID" value="PSU_v2.g16784.t1"/>
        <property type="gene ID" value="PSU_v2.g16784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007470">
        <property type="entry name" value="HemX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38043">
        <property type="entry name" value="PROTEIN HEMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38043:SF1">
        <property type="entry name" value="PROTEIN HEMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16784.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13410" checksum="56658F535D029B0A" modified="2023-02-22" version="1">MTEQEKTYAVVEETREAVDTTSQPVATEKKSKNNTALILSAVAIAIALAAGVGLYGWGKQQAVNQTATSDALANQLTALQKAQESQKAELEGIIKQQAVQLEQANRQQETLAKQLDEVQQKGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDS3</accession>
    <name>A0A914YDS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17576.t1">
        <property type="protein sequence ID" value="PSU_v2.g17576.t1"/>
        <property type="gene ID" value="PSU_v2.g17576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17576.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11567" checksum="12139866ED5253A0" modified="2023-02-22" version="1">MKADSIYRTDIIKYLLEKGAKSDPAMRNLNGSSSDSDTSLMDEDFVAQDENLFNEETDEAENFYDEDFVAEYFQLLMEKCNREIENWRLQKFLEEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFI6</accession>
    <name>A0A914YFI6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="6 9">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8 9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="6 9"/>
    <dbReference type="AlphaFoldDB" id="A0A914YFI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18078.t1">
        <property type="protein sequence ID" value="PSU_v2.g18078.t1"/>
        <property type="gene ID" value="PSU_v2.g18078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="11">
        <location>
            <begin position="192"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="223"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18078.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="43978" checksum="971F3003B4C78A99" modified="2023-02-22" version="1">MTAKPPYKVADMSLAEFGRKEIIMAENEMPGLMSMRSKYGPTKPLKGARIAGCLHMTVQTAVLIETLRELGADVTWSSCNIYSTQDHAAAAIAATGVPVYAWKGETDEEYEWCIEQTLIFPDGKPLNMILDDGGDLTNIVHDKHPEYLSGIYGISEETTTGVHNLAKMLAAGKLKVPSINVNDSVTKSKFDNLYGIRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGSAAALRAFGSRVIVTEIDPINALQAAMEGYEVNTLDNVASQAQIIVTTTGCKDIVRGEHFEKLPDDAIVCNVGHFDCEIDVKWLNKNAASCDNIKPQVDRYLLKNGRHVILLAAGRLCNLGCATGHPSFVMSNSFTNQVLAQIELWTKKDTPEAYKIGLFVLKKKLDEEVARLHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFN0</accession>
    <name>A0A914YFN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFN0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19109.t1">
        <property type="protein sequence ID" value="PSU_v2.g19109.t1"/>
        <property type="gene ID" value="PSU_v2.g19109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19109.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12781" checksum="4014F257D5987568" modified="2023-02-22" version="1">MPITHGIEYIRMFGDLDLFPPKTYSEVQDAIGKVKRVLEFYEEQTTLTSTDDQGLCLSPIPSIVSMSGSEFFDSPLLSPHSISSTSLFHGGSSIESPNNDRYNNESSFRADSNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG06</accession>
    <name>A0A914YG06_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7808 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG06"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1825.t1">
        <property type="protein sequence ID" value="PSU_v2.g1825.t1"/>
        <property type="gene ID" value="PSU_v2.g1825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056710">
        <property type="entry name" value="DUF7808"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493:SF6">
        <property type="entry name" value="DUF4789 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493">
        <property type="entry name" value="PROTEIN CBG13422-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25096">
        <property type="entry name" value="DUF7808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037104496" description="DUF7808 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7808" evidence="2">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1825.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17597" checksum="867DE838DC58FDB8" modified="2023-02-22" version="1">MVGRLCVIFAIGIALIASQEAEFKWPRWEERTLDCTSKRAGDQCILIAPNAKVNRDPAKYKCRTEAMPQTDWNVLAKNSTTRLSCPIGCEPDADLSVIQKKPFNNTLCQKYFTYGKYRDEKEGEWYLWITEPCRANLTTHCRFNDVPLSGAVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG50</accession>
    <name>A0A914YG50_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YG50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19278.t1">
        <property type="protein sequence ID" value="PSU_v2.g19278.t1"/>
        <property type="gene ID" value="PSU_v2.g19278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19278.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32042" checksum="855DD850B0CFAD4B" modified="2023-02-22" version="1">MEKLKDYKLLKYLNQGAQGKCFLYEQTKDFLKQKVVIKQIPTECSDEQLQEAEILKKCAHPFVVGFYDCFLNDSKLFIVTHFSEGGSLGAEIRGRKEANPRQFFEEDLILQYFTQITMALDYLHSQNIIHRDLKPENILLNGSKKIAKLADFGISKIIENGEFFIKSEKMLVGTGYYIPPEIYNRQNYGKEVDIWALGCVLFEMFELERTFIGPSACIAIKVLKREYNQPSRISNSYLIDIFNDCLNLNAMNRPTTTQILRSPPILKTTAKILCMTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGB9</accession>
    <name>A0A914YGB9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyruvate kinase</fullName>
            <ecNumber evidence="4">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YGB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16380.t1">
        <property type="protein sequence ID" value="PSU_v2.g16380.t1"/>
        <property type="gene ID" value="PSU_v2.g16380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="13">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16380.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19627" checksum="E1EED2CCA309B91C" modified="2023-02-22" version="1">MIANGMNIARMNFSHGSHEYHGETIANVREAASSFSDHRIVAIALDTKGPEIRTGLLAGGGSAEVELVKGNSIRLTTDPNFENSGTAVNLYVDYKNISKVVTEGSRVFIDDGLISLIVDDIHEDAIVCTVENGGPLGSRKGINLPGTPVDLPAVSEKDLKDLRFGVEQVCFRICITTNTNTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGT1</accession>
    <name>A0A914YGT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type I site-specific deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g1800.t1">
        <property type="protein sequence ID" value="PSU_v2.g1800.t1"/>
        <property type="gene ID" value="PSU_v2.g1800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.30:FF:000001">
        <property type="entry name" value="Type I restriction enzyme EcoKI subunit R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002045">
        <property type="entry name" value="Type I restriction-modification system endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008521">
        <property type="entry name" value="PRK11448.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="418"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1800.t1"/>
        </source>
    </evidence>
    <sequence length="746" mass="85435" checksum="AD1A6B0BC575E363" modified="2023-02-22" version="1">MFGEATAKHLGLLLNIPPCENQHDLLRELGKIAFVDDNILSVFHKLRRIGNQAVHEYHNDLDDAQMCLRLGFRLAVWYYRLVTKDYDFPVPVFVLPERGENLYHQEVLTLKQQLEQQVREKAQSQAEVEAQQQKLVALNGYIAILEGKQQETEAQTQARLAALEAQLAEKNAELAKQTEQERKAYHKEITDQAIKRTLNLSEEESRFLIDAQLRKAGWQADSKTLRFSKGARPEPGVNKAIAEWPTGKDETGNQGFADYVLFVGLKPIAVVEAKRKNIDVPGKLNESYRYSKCFDNGFLRETLLEHYSPDEVHEAVPEYETSWQDTSGQQRFKIPFCYSTNGREYRAAMKIKSGIWYRDVRDTRNMSKALPEWHRPEELLEMLGSEPQKQNQWFADNPGMSELGLRYYQEDAVRAVEKAIVKGQQEILLAMATGTGKTRTAIAMMFRLIQSQRFKRILFLVDRRSLGEQALGAFEDTRINGDTFNSIFDIKGLTDKFPEDSTKIHVATVQSLVKRTLQSDEPMPVARYDCIVVDEAHRGYILDKEQTEGELQFRSQLDYVSAYRRILDHFDAVKIALTATPALHTVQIFGEPVYRYTYRTAVIDGFLIDQDPPIQITTRNAQEGVYLSKGEQVERISPQGEVINDTLEDDQDFEVADFNRGLVIPAFNRAVCNELTNYLDPTGSQKTLVFCVTNAHADMVVEELRTAFKKKXPQLEHDAIIKITAAAQYRGHRRPADDRRRYSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH79</accession>
    <name>A0A914YH79_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH79"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19676.t1">
        <property type="protein sequence ID" value="PSU_v2.g19676.t1"/>
        <property type="gene ID" value="PSU_v2.g19676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19676.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10673" checksum="AFAC77FF164E5DC0" modified="2023-02-22" version="1">MNPSDTLLKQIDLAAQHQKEHHNDHSGIMHDIKESVKEGVKDVIDIVKGKDSETDSPEHHSKIESSIPPENAVPKDNIRQFNADSELRNETLGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHG3</accession>
    <name>A0A914YHG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein NlpI</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16747.t1">
        <property type="protein sequence ID" value="PSU_v2.g16747.t1"/>
        <property type="gene ID" value="PSU_v2.g16747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008391">
        <property type="entry name" value="PRK11189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16747.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28464" checksum="BF7BE65BF98B287C" modified="2023-02-22" version="1">MEQILASRALTDDERAQLLYERGVLYDSLGLRALARNDFSQALAIRPDMPEVFNYLGIYLTQAGNFDAAYEAFDSVLELDPTYNYAHLNRGIALYYGGRDKLAQDDLLAFYQDDPNDPFRSLWLYLAEQKLDEKQAKEVLKQHFEKSDKEQWGWNIVEFYLGNISEQTLMERLKADATDNTSLAEHLSETNFYLGKYYLSLGDLDSATALFKLAVANNVHNFVEHRYALLELSLLGQDQDDLAESDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHR9</accession>
    <name>A0A914YHR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHR9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16851.t1">
        <property type="protein sequence ID" value="PSU_v2.g16851.t1"/>
        <property type="gene ID" value="PSU_v2.g16851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41349">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41349:SF1">
        <property type="entry name" value="PROTEIN CBG08683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036778882" evidence="1">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16851.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38306" checksum="20202563CCF3EFD8" modified="2023-02-22" version="1">MASIKQLIFLTIFLQIVFCKIDYPKIEIYQSKNGRPLRIMTFNTWLFGGVVNDGLYKLSKHIKLMQPDIVALQEVQTQEGFQQLLDKLGPEWNGVTSPSKPNANVGIVTIHQIDNSTTTVAASNTAIGVNIHLKDTHEIISFWALHLAYLSYGPYAANNKQVTKLEQIMEGEYPNARDGRGDNIEALLKTPEFRSAVKNSDKNALIVCGDLNSPSHLDWIEETKDLHGGWVVKWPATFLLQTKTGLKDSFRELYPNPRQIPGITWSTVNRASGAQWDYMIPEPLDRIDFIMFKNPKLKPVHSFTYFGNEPLKQIPNHKNNDYPSDHFSVITDFNFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHS6</accession>
    <name>A0A914YHS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18348.t1">
        <property type="protein sequence ID" value="PSU_v2.g18348.t1"/>
        <property type="gene ID" value="PSU_v2.g18348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18348.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31077" checksum="6188031D2ED521B4" modified="2023-02-22" version="1">MIVLLFTLISVVAASAAIYYFAAIYNSSFWKRRGIHGPEAANPILNHYDEIINPEIPGYLAFQKWTEIYGNVYGLLEGWRKILVTSDPKMVHELFVKKFEYFHGRKLSAVSGNVDKCAITNMFTARGSRWKRLRTIANPSFTVNNLKQLMPTIDDSCKVLVTHFDKAFEGGKPFNIHPYYFELSIDVIFRVALGQIGTRQFANPNLAIAKSVVWQFWNDIFDKPANLFPAFGPMFEKLYMMYAFSFGKIPFGQLFSTLHKTVEDRKRTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI10</accession>
    <name>A0A914YI10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI10"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16956.t1">
        <property type="protein sequence ID" value="PSU_v2.g16956.t1"/>
        <property type="gene ID" value="PSU_v2.g16956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581:SF3">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581">
        <property type="entry name" value="PROTEIN CBG10435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037869987" evidence="2">
        <location>
            <begin position="21"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="162"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16956.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28514" checksum="7F16F68B5C90EE58" modified="2023-02-22" version="1">MNLFYLFRFATAWLNGMVNGKIIEMNEAGNKYWIAKENLAALTGDVPAAGLVYTRLVSMVSSRYNEAIKSAKEKPDEMKTKENDQEGHPHGHGKTHEEHGSNHGHGNSHGHQHGHNHSGGHGHDNHAEQFPLMELLSKTMYKKHLIPDFMPLFGVREKLQNGGIEILDVGCGSGFQICEFAREFPNCNFTGIDISQSAIKRAQEVAKEQNLSNVKFEVISGEEMPAEWDNKYDWVFSWNSIHDHKHPKTVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ16</accession>
    <name>A0A914YJ16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJ16"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18827.t1">
        <property type="protein sequence ID" value="PSU_v2.g18827.t1"/>
        <property type="gene ID" value="PSU_v2.g18827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054210" evidence="1">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18827.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9512" checksum="FC595136013532B2" modified="2023-02-22" version="1">MECLKLMLLILLYFLELWCASNQCEVDAGFLQIGAKKVAHFFKTTSLNAVTKQCDTVKMKSPTTKFFDVEDSSCYPKNMMEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ93</accession>
    <name>A0A914YJ93_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biopolymer transport protein ExbB</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The accessory proteins ExbB and ExbD seem to form a complex with TonB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ExbB/TolQ family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJ93"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19582.t1">
        <property type="protein sequence ID" value="PSU_v2.g19582.t1"/>
        <property type="gene ID" value="PSU_v2.g19582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050790">
        <property type="entry name" value="ExbB/TolQ_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30625:SF14">
        <property type="entry name" value="BIOPOLYMER TRANSPORT PROTEIN EXBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30625">
        <property type="entry name" value="PROTEIN TOLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74653">
        <property type="entry name" value="TolA/TonB C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52015">
        <property type="entry name" value="TONB_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="TonB C-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19582.t1"/>
        </source>
    </evidence>
    <sequence length="355" mass="38503" checksum="8B8F77D1FDF16C4B" modified="2023-02-22" version="1">MNPPRYPPAAFRAGIQGEVILIIDVDASGNVTNVTVEKSSRNRDLDRAAMEAARKWRFNAAEAGGKKTAGRVRVPLSYTLYHHTQQKVSVMLQEIFIAAAAGGNPSNALSQMGFEHLIHETTTKPGDFAVSWVVLLTLIAMSAMSWYWTVINIFRATRLKSAADRVVSLFWDTPNAQDAIRAMEEQPASEPFSKIALDAAQAAAHHQRAEGGATGGVGENLSRSEFVDRALRQAVTRESNKLQSGMTLLATVGATAPFVGLLGTVWGIYGALIKIGATGSASIDAVAGPVGEALIMTAIGLFVAIPAVFALQLLQQDQQRDHQQVRYLRARPARLLRHRFARPLIAARVTQRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJY6</accession>
    <name>A0A914YJY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19842.t1">
        <property type="protein sequence ID" value="PSU_v2.g19842.t1"/>
        <property type="gene ID" value="PSU_v2.g19842"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g19843.t1">
        <property type="protein sequence ID" value="PSU_v2.g19843.t1"/>
        <property type="gene ID" value="PSU_v2.g19843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19842.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19843.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10285" checksum="5E6AB636B06C30F4" modified="2023-02-22" version="1">MVGYVAYDNFNPTLCYEYAPSSRGSYRCTSCIRFRKHTIAKIDESRRILQSASHVCHGVTIDEFEALQAQRRHWSSPTNIIEFEDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKH2</accession>
    <name>A0A914YKH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20023.t1">
        <property type="protein sequence ID" value="PSU_v2.g20023.t1"/>
        <property type="gene ID" value="PSU_v2.g20023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036814441" evidence="2">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20023.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23398" checksum="0C385E742A04BFB9" modified="2023-02-22" version="1">MAAVRKIFIILLIFCNKIVCMPLRHQIEDDNNITVKTIEIFKNEHKTVYETVVPLKGFLVTFPPNVSQQNVPFALANMNVINTAIHRIKANEQGKQVDKQEEKKKEVERNANNIRKDMEEELKRVNQQLQIIETLDEGRTKAIMEINNLFDLFFWDEYVQTHHFNTANKTASYIENQLIDCYDNNSVRLKHTVFDDFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKS2</accession>
    <name>A0A914YKS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19943.t1">
        <property type="protein sequence ID" value="PSU_v2.g19943.t1"/>
        <property type="gene ID" value="PSU_v2.g19943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19943.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="21146" checksum="DC3681FC9AC7CBB6" modified="2023-02-22" version="1">MLTDQCVIVSLREPIPYRVVEKMEEYNVITLIRDCDARCDPKAPPSLTIDQKVTEFLPPLNIPPGIAYFNALLHCDEIYVTKFQTNFKSFPSKIMFYWDENNKKFSNLISYGTVLIAKHERSFAINHEEGYITATYSNPEDDIFQCWSTDVKHFCQRELPPRLFATIPRKLVYLYLFKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKU4</accession>
    <name>A0A914YKU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKU4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20151.t1">
        <property type="protein sequence ID" value="PSU_v2.g20151.t1"/>
        <property type="gene ID" value="PSU_v2.g20151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036758794" evidence="1">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="85"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20151.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="33870" checksum="034CAD8D36C0B1AB" modified="2023-02-22" version="1">MVIKIGFYISLAVLFLLCQNIVAEEAPPPLPVDYVKDITETTPIGPITGFVAKLSENFNADIFLGIPYASPPIEDLRFEASRPSTGWPVLVWVHGGGYVVGATFMYGYQNISLNFATQDIIVVTIQYRLAFTGFSSTGDSEMPGNLGYWDQTEAFKFLKQNIGNFGGDPEKIVAFGLSAGGGSTAALSMSPHSRDYISSSIEMSGSVYANWASSDMVVAVTKQVAREIGCPETSAELKKCYKQTKPEKFLEAIEKIGPARRDINLVKYNPRIDGDFFPKDFTELIKESPPKPALIGFTDQEAGYFSKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMC8</accession>
    <name>A0A914YMC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fasciculation and elongation protein zeta-2</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21493.t1">
        <property type="protein sequence ID" value="PSU_v2.g21493.t1"/>
        <property type="gene ID" value="PSU_v2.g21493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21493.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42269" checksum="18F8E409A22D6A9E" modified="2023-02-22" version="1">MAQEQIEIQAQNAKVVLNLLHESERSENLSSSSSSTLEGLSTSLEDLVGCFDQKVNHVLKDLGESTIQMAPVQIRTQDEIMSESQVWYTITGNYGNLPPLDFQKTYIRKNQIESLNLSSPRDEDDNIEDAGYDDPQHDEEDYRQAMDLHQLISHQLNLHGENPPISADEVIEEIDEIMQTCDLIHSMTTDRTNDSSADSMYSSMRSPFTSTSQNTECDYKFKHTAALNVTSEELSTLPQSKLLTLMAEMEQLIMVYNAELVSELAHRDEMIYEKECKNKFVTLLVKIQDQRRKFQGQGKKKKLLSKLEGSPSPQFMTASIPFDEENTVLDVPTLESMIKILDAISEDSQQVPNLLTDYILNVVCPSTETSVIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMR0</accession>
    <name>A0A914YMR0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMR0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20220.t1">
        <property type="protein sequence ID" value="PSU_v2.g20220.t1"/>
        <property type="gene ID" value="PSU_v2.g20220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20220.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9922" checksum="E4CC9580A763A488" modified="2023-02-22" version="1">MPRDEIQRLFSPSIKAIYEQVVRPIKRLKPSEFEYLTMMGLIIWKCENTELNSNFVEKAKTELLESLHNYFINEKKLFVTPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN78</accession>
    <name>A0A914YN78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YN78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20407.t1">
        <property type="protein sequence ID" value="PSU_v2.g20407.t1"/>
        <property type="gene ID" value="PSU_v2.g20407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20407.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16583" checksum="E00532392EEC5A8F" modified="2023-02-22" version="1">MVEIPEVEKYETSDKFEELNFGCLEKVAGYGKSKNICSIYAKSSSTSAFISGVIKEGLATFKLIDPKLSPLHNHFVAYNEGDRIIYLRGEIKFDSLEKGQELSEYTMKDFRPYGLPGDSVSQYVPKWLGGYDSGNNAFNLHSSVSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNH5</accession>
    <name>A0A914YNH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 87A</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNH5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2418.t1">
        <property type="protein sequence ID" value="PSU_v2.g2418.t1"/>
        <property type="gene ID" value="PSU_v2.g2418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037679505" evidence="7">
        <location>
            <begin position="20"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
        <location>
            <begin position="233"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2418.t1"/>
        </source>
    </evidence>
    <sequence length="567" mass="65550" checksum="4B59371EF0A12AE0" modified="2023-02-22" version="1">MKLQGFLLFISALLPFISSNLLSPGIVRKEVTVTQKKIEYYGFFQSALNGSEVEIRMMCEDDILAQYSVQYVLRSTPCAKEFTDKTRLSKMNNMLEFYFNKEYEIPDGFHYDSIYFYKSALKNFSCNNGIHVSFDENGRPPMQLHNVTEYGTTNNKHKREALLNGNTIDGGAKRTLTSWHPAQVLPDDAIYVLIVRIAYAGGLQNPESEQGFKVLLEAQWRGPYGYLSAIDYPLLHFYGFMCVIYIFLSFIWLIVCFKHWKDLLRIQFWIGAVIIVGMIEKAVFYAEYSNMNDAGESVEGLIEFAELISCFKRTVAHVLIIIVSVGYGVVKPRLGATLNQVAAIGVIYFVFCSIEGLTRVSKSSVEAMKEKQVAKIPLIILEIGIAYWIFTSLINTMRSLRMRRNEVKLALYRYFTNILFGSVFVAVVYMMWSIYIHSIQYCLPDWKQLWIDTAFWHIFFCSILIVVMYLWRPAVNNQRYAFTPLLDDSEDENDDELFNSQIPVYDMITQRSFERGRVEYHSQKTTDDKLEDDLKWIESNIPTSLAEALLDDEEEASMRQLEISKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNK9</accession>
    <name>A0A914YNK9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YNK9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21193.t1">
        <property type="protein sequence ID" value="PSU_v2.g21193.t1"/>
        <property type="gene ID" value="PSU_v2.g21193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21193.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20953" checksum="3238F01F20716546" modified="2023-02-22" version="1">MNKKSTGSFSTWKPRTLTEIYGSKRNKIIRVYADGVYDLFHPGHVEQFKQVKAAFPNVYLIIGVCSDADTLKYKDCLPVMNEGERLKMIDQCRYVDEAYFAPPFFPTLEFVNYLKADLVAHDALPYNSPTTDDCYAIFKSKDRFLETQRTPTISTTSLLSRIINDLDRFKARQLVRENSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPL2</accession>
    <name>A0A914YPL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPL2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19296.t1">
        <property type="protein sequence ID" value="PSU_v2.g19296.t1"/>
        <property type="gene ID" value="PSU_v2.g19296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018251">
        <property type="entry name" value="Crust_neurhormone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031098">
        <property type="entry name" value="Crust_neurohorm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01250">
        <property type="entry name" value="CHH_MIH_GIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR631098-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19296.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10551" checksum="1554F4EFB6576FE0" modified="2023-02-22" version="1">MIISSNIAEAKVYVVQTRSGNAVKPRCKVQQNSELHVLMDRICLLCHEMFSHERPNMRSDCRSNCFRTEHFRKCLAIFNPGRQAAKMLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQR2</accession>
    <name>A0A914YQR2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQR2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2519.t1">
        <property type="protein sequence ID" value="PSU_v2.g2519.t1"/>
        <property type="gene ID" value="PSU_v2.g2519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="216"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2519.t1"/>
        </source>
    </evidence>
    <sequence length="438" mass="48939" checksum="51FCCC42E2BBCA10" modified="2023-02-22" version="1">MGNQVARGGGGKRQMPQHAAQKVARKLQKGRGPDALNKLPQVHPRRQCLLRLLKQNRVHDYLLLEQEFIQRQNSLKPNHNQSRQDRKTVQQLRGTPTTLARIHELFNDEQHAVVVVEGSKREWYIPILSIVDKDLICLNALVMVKAGGMFKNVPLAVVGVLQDSVDSKAACYKLEKAPKESFADIGGLESQIQEIREAVELPLTHPEYYEEMGITAPKGVILYGEPGTGKTLLAKAVAHSTSATFLRATGSDLVQKSSGEGARLVRDLFKMAKECAPCIVFLDEIDAVGTKRFDTSSRGEQEVQRTLLELLNQLDGFESRGDVKVIMATNRIDSLDPALIRPGRIDRKIELPKPDEKTKTKILSIHTAGMTLAKDVKFEKIVSKEREISGADCRAICTEAGMLALRDHRKIVCMDDFNRAIKSVLYSKKFGVMEEFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQY9</accession>
    <name>A0A914YQY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3194.t1">
        <property type="protein sequence ID" value="PSU_v2.g3194.t1"/>
        <property type="gene ID" value="PSU_v2.g3194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3194.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48944" checksum="01E4015153212284" modified="2023-02-22" version="1">MLVVCYTNHALDQFLEGISKFLEDGIIRVGGRCKNPALEQYMLSKKRQWDNPTLRTQFFHLRRGIGQLQTNMEEKSAFLKELETRFTSPELLLPVITNSETPYFFHSKDLYKKADPKSNEALMFKWLTQTYRNRRSNQNDIGIIRQLMDWRVSEIKAKNALFRAYANEERVDAFGLFGKLKTTRQYRFLSDVRLFREAEQWPLINDVNEVIRLGYNEAVAIELLVNNNLATIRQEHNRVRTANPDKELANVRLPETSAATASAGEDEEMDISDFKNDEDENRMLVDTNILDEGFVTQKKQTTKKDGTKKSQNWFNPEILPSFINYITVAPPMIETEANAVNDIWELPLQSRWRLYQYWIEKVRDVINVELKNLEDEYSENVKRLTELRSLADVSILKAAKVVGMTTTGAAKHQKHFDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSS4</accession>
    <name>A0A914YSS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSS4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3746.t1">
        <property type="protein sequence ID" value="PSU_v2.g3746.t1"/>
        <property type="gene ID" value="PSU_v2.g3746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3746.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19493" checksum="AB523FEABB89EE92" modified="2023-02-22" version="1">MLIKYEESIENLSESSIADDDNISAKRFKSDNENENVKTSQSTLFPQSLPEIFARNFQASSDSETPPYFNILNLMAAQRAAAVAAMGFQAGNPLAAAAAANWMLNGNNNFGKASIDNEKVKAAKTESPSTKEVNNEKTLASTEMLSPNNVASAITAKFFSNANSSNQVAQAIIAHLQQRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT92</accession>
    <name>A0A914YT92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT92"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3214.t1">
        <property type="protein sequence ID" value="PSU_v2.g3214.t1"/>
        <property type="gene ID" value="PSU_v2.g3214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3214.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40455" checksum="567E9E5773947D2C" modified="2023-02-22" version="1">MNELKFVNDERNEKEMTFDEKFRFVMENADSDKLQMIVAKEAKMSEERIALIRARDFEVDRLTKACETAVNESLEKREELEQTSYNLTVINEKLKQVNINYDLQLKALSERQRQEYRDMITVMFETDTVPEYIRSESPPACVIRKITTEATTVRPSGPTLRDESFTIHIGTQVKTTHNIRIMQGNSLVEKLAAFNDDPNPEHDFSQRLYTLMNLYGSDLSAVVLLVDRDPLFHIHNRTQFFRICERNTELHFDDIEVQLNSTTQQTLQMNKVRKNELPESTSYDIPTSCSKFDEQLCEVGDLMVTKHSNLNNAHVVFHLVVDKTLESDEIASRNAIMLGVRKIFQAASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTI2</accession>
    <name>A0A914YTI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3993.t1">
        <property type="protein sequence ID" value="PSU_v2.g3993.t1"/>
        <property type="gene ID" value="PSU_v2.g3993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401:SF6">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037747973" evidence="1">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3993.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28798" checksum="4990FA49B3160A8E" modified="2023-02-22" version="1">MITPKIFIFTFVFSLLLNFTTSQPAENILRPDASMIEEVAKMFLTQFSSILSPKTIAKFAASHPSSTMTSTSVPLVTEKIRQCTCSESDECVSEAYRSNSFCQNSCKSHLEYYSSHPEEFLACFPKNPSGHFMIIKCLKENIPQFCSADGSRFTFIPKSNYNQSATFELNFDLGKKAIDIVVLEHLKAFFACSGFCMKEKIVACYERKSCGIYLPSNHDLGNIADFCPTLKSSINSNLMKALPCFAMQQVFPKFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUQ0</accession>
    <name>A0A914YUQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUQ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21206.t1">
        <property type="protein sequence ID" value="PSU_v2.g21206.t1"/>
        <property type="gene ID" value="PSU_v2.g21206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21206.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7480" checksum="72BEEA8186923C40" modified="2023-02-22" version="1">MCFMRVSAIRYATTVGNTMRAWMTENYRGPLVCREVTIPSITQPNQVLIKVKVGFIIVIEFTTVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV80</accession>
    <name>A0A914YV80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21414.t1">
        <property type="protein sequence ID" value="PSU_v2.g21414.t1"/>
        <property type="gene ID" value="PSU_v2.g21414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21414.t1"/>
        </source>
    </evidence>
    <sequence length="789" mass="87282" checksum="E30150F38197765B" modified="2023-02-22" version="1">MLTEKGKQPEIEARRLFQQIVSAVAGCHGSGVVHRDIKAENLLLDKDNNAKLIAWCGSPPYAAPELLLGQEYDGTKSDVWSLGVILYILVTAGFPFPGDSVEKLKRAVLSEHLRIPFWVSVECADLIRKMLTVSPSKRYSLAQVSQHRWFTENISDSMRDLVKSSLNNERRASPSPAICLTVDRRLSAKILDPAVMIFMQQHTNWTEEQIVEDVLKQNFEGPIFATYELLNNKLAEFKDNVIQLESDEHPRRGSRGSILSGKANVEPELPQTTIPAHHLAKLSLSTSQDYDSDDSSASDLTANEESSSSPRYRVGGAYSRRRMRRNLYQNIPEQQPSEQRRHTLCAADRLPINPLISTPQLPLDSVALANAAAIAMANFARLQQLQRQHQQLLQQHKLANTITGNMPALVNIPVSQERRASANEALLGLNSYAHLLAAACSTMGMPNAADVNSKNTSNPPTHPTVEEEGQSYLNHYGLLKRNTLHAVSGMSSLNGIPSGSQQPQQPRHSRTPYAKQNGNERRSSWASTTSSSTAAGHLSQQQQAQLEKLYRQSIGGGTTSNTDALTGVQQLQREFQKLKACTQEQQQTQQNPLQNRSFSMIPPSILEINPPPTISITDEHNRCFPPASGPFDPMSFMSQSNQGHGTQSLTGQPRPATVIGLASTSSTASTPDSQPSSSSAMTIDSTGKTNAAVKYYFIPVSLEVALERLPKFADNTENLIYEIAPDTDLSKDMAHVRFSHKNGVLFEMILHRMNQSPNISRTEFFMLHGEQSEYDTLRTQLLAVFNEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVL0</accession>
    <name>A0A914YVL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21548.t1">
        <property type="protein sequence ID" value="PSU_v2.g21548.t1"/>
        <property type="gene ID" value="PSU_v2.g21548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12934">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LEM" evidence="1">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21548.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10547" checksum="21098BBFB6BE9123" modified="2023-02-22" version="1">MEIEDISNIVLDDDEASFEVVEEEEKSIELPEDIKNLQIIELRERLIKAGFPPGPVTITTQSMYKKKLFIQEMKNFKEYGVRENLLPFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW17</accession>
    <name>A0A914YW17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW17"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2278.t1">
        <property type="protein sequence ID" value="PSU_v2.g2278.t1"/>
        <property type="gene ID" value="PSU_v2.g2278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2278.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12786" checksum="F0C56533FEE76F87" modified="2023-02-22" version="1">MESHSSSSHFHHPQSHPLNGDTSIHTVLINLVERLVEILKKAEELPKYPHQKSHVPFWAWMCFLACGILCVFMTIGLCWIRSTTRRSSQRGKPGIVATAGRSWKAGFGGGIYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXM9</accession>
    <name>A0A914YXM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methionyl/Leucyl tRNA synthetase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5262.t1">
        <property type="protein sequence ID" value="PSU_v2.g5262.t1"/>
        <property type="gene ID" value="PSU_v2.g5262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5262.t1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42001" checksum="78D5D9D7AA3F1829" modified="2023-02-22" version="1">MKTTLLRRGISTICEEKPTKSLITMPIFYVNGDPHIGHIYSAVLADATHRWTLLKAGKDADPSKFKLTTGVDEHGAKVELAASLAGLQPQQFVDQNSAKFQKAFKKFGILNTDFIRTTDDKHKKAVTSFWDTLKSNGHIEKANFEGWYSPIDECFYTEKEVEKVNVDDRFELIISKETKNPVEWIKEDTYMFNIGKFQQPVRDWLNSGALRPNNFLPSALTSLRSNERLSVSRDAKNVSWGIPVPGDNSQTIYVWLDALVSYLTAAGYPDSSSSNIWPADVQIIGKDILKFHAVYWPAFLMAADLPLPKKIFVHSNWLVNGHKMCESYGNILNPKDASEVLTCEGLRYYFLRQGKPHDDGSKFILNDTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYE3</accession>
    <name>A0A914YYE3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L14, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4971.t1">
        <property type="protein sequence ID" value="PSU_v2.g4971.t1"/>
        <property type="gene ID" value="PSU_v2.g4971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040807">
        <property type="entry name" value="DUF5522"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17653">
        <property type="entry name" value="DUF5522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4971.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33529" checksum="8C93D78A61F0047A" modified="2023-02-22" version="1">MFASGRWYPQPEALRFYSTIENSSSSLVSNDSKTSISVKKPTPEEFGLPKENAFPVFAKPRGNGKKVFGLVPWKNGEMIADYVLFEESMKLAETSWLDYDGMTRDEREIYIAHLNAVKNRKLSYIDPKTKFSVMTVSKLLHQEKCCGNGCRHCPYGYEMSKHRSRPPTTGIHRRTRLLVVDNSNLGKEANNSGKLAYCIHVYKSGYRKKHMPKAELGDKILVAIRGEMKKGFIVGANTHIHFRKHGVPSTDTNNLVLLDDEGNPLGNRILAPIPATLLQKRDHAQFAKVLALANKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYP4</accession>
    <name>A0A914YYP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5073.t1">
        <property type="protein sequence ID" value="PSU_v2.g5073.t1"/>
        <property type="gene ID" value="PSU_v2.g5073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF69">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="114"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5073.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="45289" checksum="CCBEFC83338A5BB2" modified="2023-02-22" version="1">MITTLGYGILDPMTINGRVFAVIFGCLGIPITVIMFSNFGRYLQSLEVALTRLCCRRKSRQRIKDEDIQDGESMAGGLTEIDAEVSIDGSEESSIDLLDDMEQISAPLLIGTVILYMALGGALIPYLNGSFDFFNGIYYSFLCLTAIEFGESVPRGNQQYIPIVIVYMSLGLTISTIALDLGAKYVRKLYFIGKKLKNIANAKIWFGAKDLSVKDVIQALGQNIGLDQAVLAEINLEQLISDAILVKEGKLSRVPQTHMLVEGIWPPELVPLFIKDGYFPGFADDDPDQDEMEKKISPLTNLPPTLTLSNASRLTQFAANTGIPGAIRRASRKFSSGSARKGEKLTVRFEDVVYSNGDERDFEASSVQHINHKTLTDVDQSSALSDPSSLTSYARFLHSPSADSIDSELVVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Y6</accession>
    <name>A0A914Z1Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Y6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4266.t1">
        <property type="protein sequence ID" value="PSU_v2.g4266.t1"/>
        <property type="gene ID" value="PSU_v2.g4266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4266.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8390" checksum="D7A9F2EF57E944B3" modified="2023-02-22" version="1">MSSGLVPVTNRVSAVPEFVDESCGILASAEDAGQLADGIAALYLDADAFLAYSKKAAKRVRAQSDARLVIKREISLIAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2U5</accession>
    <name>A0A914Z2U5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2U5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6385.t1">
        <property type="protein sequence ID" value="PSU_v2.g6385.t1"/>
        <property type="gene ID" value="PSU_v2.g6385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="112"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6385.t1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37912" checksum="2A4F76344FBA3269" modified="2023-02-22" version="1">MTDKTRGAKSRGKRNKSEEDDQSSRSSGSGSDKHHDKSKSDKHDKSSDKQEKPDAPPEEQQQQSQQKKHKKKKKKNLVEFNAEERKQHRIMTAAERPKLEAGDAVSGMKYKFEVISLLGSGGFGDVYKVKPEEKADDIPDYGAAMKTELLNENNNPMMNRLKVECQILKMFETLPPEKKMHFTEMYDRGITPSFKFIVMELVGQSTLEAVENLHEIGYLHRDIKPHNYSIGLGKRANIIYMLDFGIARQFVKSGTKVLRIPRECVKFLGTLKYASRACHQNKEQSRKDDLEAWYYMQLEFVDHPAVFWSQFKDRKQVIIAKEKMFAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2X2</accession>
    <name>A0A914Z2X2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2X2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6408.t1">
        <property type="protein sequence ID" value="PSU_v2.g6408.t1"/>
        <property type="gene ID" value="PSU_v2.g6408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6408.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25038" checksum="51D05769EF6DAAD7" modified="2023-02-22" version="1">MSQRRARNELEISQPSIHRILKDHQWHPYKLQMVQQLLPHDPQSRVNFARNQLNLLAAEPEFFHRIDWSDEAHFHLDGGVNRQDFRYWSAENPHFHTSKALNPPRLTVWAALGSSGVIGPFFFRGINGQTVNVNGQNYLAMLQQFYWPAIQNRPNIGVQIFQQDGAPPHWTLAVRAWLDATFPNRWIGRDSPIMAWPPRSPDLTPMDYFFWGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3H5</accession>
    <name>A0A914Z3H5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3H5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6582.t1">
        <property type="protein sequence ID" value="PSU_v2.g6582.t1"/>
        <property type="gene ID" value="PSU_v2.g6582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6582.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="26955" checksum="BB9D80462025E2F7" modified="2023-02-22" version="1">MTAASQNSGDPFYVVTYYKQTCNGDANLNKAMEVLTDKTAQTRLRGVVTNIVNTMPTQIQSIALALIDQSFSGKIVTQAEAQGYVTKIKNLNTATKTAIFKKLPILKKVLNKNEEYSPLFKPYNTILTNLPILVSNKAPTATQRKSINTAMGKMQKFAHNNAVPFIQFALNWLKSLPIADSQNDPTVLQNYRTGAAKIAQTGKVALMLPTTQQIIATYFTTPFKLPESSDAALNALTQEASKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3J7</accession>
    <name>A0A914Z3J7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MROH2B-like HEAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3J7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6470.t1">
        <property type="protein sequence ID" value="PSU_v2.g6470.t1"/>
        <property type="gene ID" value="PSU_v2.g6470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="1">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6470.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19727" checksum="1178E5FF107B12BA" modified="2023-02-22" version="1">MGICNFLVRTCSDDSLPLEPYLDEILNSIFQHVAVHNDAQLEENYRASANPTVMRLRNEVCRCFLAASQRFADRLVYYLLHKMQSVNDSTKLGAIDLIRHLLNSAECSMEDKRALIVMGLKPLLRDEGLSVKAKMSMCQLCIALADHGYVHSDSGGDNVIFFLTSNLIADIDAATVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3U3</accession>
    <name>A0A914Z3U3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3U3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6678.t1">
        <property type="protein sequence ID" value="PSU_v2.g6678.t1"/>
        <property type="gene ID" value="PSU_v2.g6678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6678.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7785" checksum="A512CA2CF20F2532" modified="2023-02-22" version="1">MSTLSDDKWTLKINENIHKVIQQKCFGVPWISVKNSRNQNADFFGADRLPLVFRFLEDDKKRSMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z400</accession>
    <name>A0A914Z400_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z400"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4980.t1">
        <property type="protein sequence ID" value="PSU_v2.g4980.t1"/>
        <property type="gene ID" value="PSU_v2.g4980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="399"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4980.t1"/>
        </source>
    </evidence>
    <sequence length="770" mass="87927" checksum="CF650F0055C8820C" modified="2023-02-22" version="1">MKFKSKNGFSTTVFEVDPNLEAAPSLDFCGRFLKLQTLNSPYLANYVEFTRLASDSSKIALTTEHPRGMPLSAVLPNLNQNEKYEITFHLLNALRYLHSEGITVGHLLPQNVIVDVSSKSCSVKLIHYGSLYLFGKNIFDDIYNIFTLTPERIMKIRATQKASDLFALGILLVCIQMGTDIHSEYSFSKYWQSFTSILLQLSDPFCDISIGDKFDILFQNVYDSQNQSKDSTVHSAIRNLLKIHPFKRPHLTTVLSLFDPKPKQPLISNDFPPDIQLHLWKLCGKSIERNLIESKFIHVSASIVMLSVGHPISRFIMTNDKDKKHVKTHYKIFIQPDENFHEAGRAAKEYLDHKNILRYRSGCNEFERCRSAMTFTSQFERFVAFYEDVYHGRKALSADTPNSIRAKIWARRLIPKGLPNYLFYVSNNLLAKSCKHQLSLDLPRCHQYDESMTSAQIQSKITALIEKILAVSPDSSAYWQGLDSLIAPFAILYANDLESGFGVVFEIIQRFTPEYFTRLSSHALEESLRTFSRLISFANSRLACFLRVNGLSPSTYAVPWLLTCYAHVFAFDKLFRIFDKMLDRDASYPLAIGISILEICAVDLMDAVRGDEAFKVLSNVSDIDITKLLTYSDRFDENIPATCYYRKHAEPPRRAPNLTVKYSEAEDNELLVPKIHRDDFYQYFCRNDAILVVCNGESTHPQIVSISSNGFNESIEKIVRKKQEENKVVGVISNDEQLAIKAANELTDCSIDRVCVVDSSWLSFQWNHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z430</accession>
    <name>A0A914Z430_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z430"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7455.t1">
        <property type="protein sequence ID" value="PSU_v2.g7455.t1"/>
        <property type="gene ID" value="PSU_v2.g7455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037915999" evidence="1">
        <location>
            <begin position="17"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7455.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20346" checksum="F9D36987E60AF34E" modified="2023-02-22" version="1">MKLLLFITFFIATTIGAPVQNLGDQVVRQEQVVLNVLYKGRNLNVWKQDINNYSRFYVTPLCIIDLNSFSCDKNAYQIPARWVFSFKVKLWDFEVATLVQKALKQKNIIAQPGDIIILPMQSVRVGLRNPTPNIKVDYKWTPFGDQSLVMTFELYPKDEAFCHTMVGFLYFTNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4G8</accession>
    <name>A0A914Z4G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4G8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5143.t1">
        <property type="protein sequence ID" value="PSU_v2.g5143.t1"/>
        <property type="gene ID" value="PSU_v2.g5143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5143.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12479" checksum="058EF1AA6C5E09AC" modified="2023-02-22" version="1">MNGSVTISFTMCYDCKIRTIKSKFSMDKKFPIDRKDAHLPHSNNNGTSMIQPAVAKYRQPPAAQPDQEEEQEERDGQTFLTPVQKYSDYIPQAPYAQRTRLPLFQPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z542</accession>
    <name>A0A914Z542_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine-hydroxylase NDUFAF5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Putative methyltransferase NDUFAF5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z542"/>
    <dbReference type="WBParaSite" id="PSU_v2.g747.t1">
        <property type="protein sequence ID" value="PSU_v2.g747.t1"/>
        <property type="gene ID" value="PSU_v2.g747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="6">
        <location>
            <begin position="76"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g747.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36892" checksum="C4B2DA47F4E3DD83" modified="2023-02-22" version="1">MRLTIISKINYTKLLFAASKTSASSLKIFDRKTKLKQRNWAAAHPDFDVCQYVKDEIGYRVADKVFDLTKFNDIVLDLGCGGGHIGQHLIKENVGVLLQCDMSEGMIRKSKGAPEDELPTLRVIGDEEKVPFKSQSIDLIVTSLSAHWINDLPGWFQRCYNILRPDGAIIGALLAGDTLYQLRVALQLAENERLGGMGTHISPFIDAQDIGGLMNKAGFEMITLDSDELEIGYPNMFALLYDLQIMAESNSTIKRTASLRKDVLIAADSIYRIMYASENGYPATFQIYSFIGWRPGQKGPQKAAKRGSQNVSFKDLSEVIENPDKFVPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5U9</accession>
    <name>A0A914Z5U9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5U9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7283.t1">
        <property type="protein sequence ID" value="PSU_v2.g7283.t1"/>
        <property type="gene ID" value="PSU_v2.g7283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="45"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7283.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32795" checksum="E91C22005162010F" modified="2023-02-22" version="1">MQIGNKISEKTLTFLNTRSPGPLVEYHPEGKILMGLDFHDYSFQTRYYFHPSYFSVHAYKHDIAIIEFPEDTDFQIPPIKLASNYVEKDGDMAIAAGYGFYKWQGSQITGTPEHPKVLQNATVPVHASCPGISSASICSATCERHADQGDSGGPLMFKRNGTYYQVGVFSTINPYNETFIINTYTRLSLECEWIKKITKGEAKCEPLPEDPNPQPSKPVALNQPKCAPVKPASQPDEEGHVNPADQTEIPSDQTGIPSDENGVTAPQISQTEALKSNSNFAALNIILFFAAFFFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6T5</accession>
    <name>A0A914Z6T5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6T5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7617.t1">
        <property type="protein sequence ID" value="PSU_v2.g7617.t1"/>
        <property type="gene ID" value="PSU_v2.g7617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF91">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="286"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7617.t1"/>
        </source>
    </evidence>
    <sequence length="673" mass="77676" checksum="64A7D48BB05C4691" modified="2023-02-22" version="1">MRCHIPTLDKPLMRLFAWFTRYYLVDYYWLFIILPFILTGFLSCGFIWIAELTLLDAKRLYTPQSAPVWEEEKLLKKLWPIRTNEFLPERTFEWNRYVYLVVHGREIDGYETHTYPNILEEKYLNEIEKLEASITTDVKFPMKDKWRTAETAHINETVNFKDICLNWNGDCFRQTGIIKLLKNRFEFESHGIGITFPRANTKGSPIYLAFNVGGVETFKNDSIKVVKGMRLWYFFRFDTPEFDQMGIQFEKEAIKYVEKYWSNNSLLEVHGKHSRSFDQGLTNNANRLKPYFAVTVIVLIAFTSVYSMKWIFGSQRGSNCFVHIDWLRSKPVLALGGVLSSGMAIISGIGLLLWFGCFFAEITLVAPFLVLSIGVDDMFITVAAWHNTELKFPGKSKEVLKERMVEAMSEASVAIFITSMTDVFSFAIGCWTDILAVRGFCMMTSACMFFTFLYQVTFFAALMVLSAKHQMEGRNACIPCLQAKDFYAIDTPTNPPSTTSSTAKIHVIDKNVINQKNVEKQLSKYVVPVSSPQHHHPRQPSHYGTNQPTDDEIQMADRNRGYMGSFFRKYYVNFILNWKTKIVIFIIFIAYIALSIWGLVTMEQGLDYDKLLLKTDPLCRTLNVEIELFHGGDQIEIAIVKAPNMTYPSNRKLIENIVKEFETVEYSIGPKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7S6</accession>
    <name>A0A914Z7S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7S6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g792.t1">
        <property type="protein sequence ID" value="PSU_v2.g792.t1"/>
        <property type="gene ID" value="PSU_v2.g792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02042">
        <property type="entry name" value="ParAB_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050678">
        <property type="entry name" value="DNA_Partitioning_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13696">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13696:SF52">
        <property type="entry name" value="PARA FAMILY PROTEIN CT_582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g792.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18691" checksum="A260885D3F1378A5" modified="2023-02-22" version="1">MEISNAPDRTRRLRDALRFDSGIADHFSYILIDCPPSLNLLTLNAMAAADSVLVPLQCEFFALEGLSQLLETVNQVRNSLNPDLTIQGVVLTMYDSRNNLANQVVDDVRAFMGEKVYRTVIPRNVRVSEAPSHGKPAILYDLKCAGSQAYLQLASEVIQRERQLRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8K6</accession>
    <name>A0A914Z8K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8K6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8178.t1">
        <property type="protein sequence ID" value="PSU_v2.g8178.t1"/>
        <property type="gene ID" value="PSU_v2.g8178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8178.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18192" checksum="54B86831338AECDD" modified="2023-02-22" version="1">MAILDNSPMIISAKVQHKAAWALKTIAAGNLDQTQAVVDAGGVPALVELLASPHLDVCEQVVYALGNIICAGTNFRDYCIKEGCIEPMLKLIKSDTIDVHLLFSIALILPNLFSNPALPCEIVYALLPALAEQILTHDPIILTDTAKLISFLTAGKEDEFQQVNYNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8Z7</accession>
    <name>A0A914Z8Z7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8Z7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6720.t1">
        <property type="protein sequence ID" value="PSU_v2.g6720.t1"/>
        <property type="gene ID" value="PSU_v2.g6720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002619">
        <property type="entry name" value="CX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520:SF8">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01705">
        <property type="entry name" value="CX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037871141" evidence="3">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="CX" evidence="4">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6720.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="40352" checksum="744D837C562702B1" modified="2023-02-22" version="1">MFKQVFFICILLLSPVHSRRSSGGGGFRGNSAARQNVPAGGGAPGGFNPQSNQGFHPQPNSGFHPQSNQGFNPNQGGFRPQPNQGFGGQHPGGGFNQGPAGGFSNNRGFGGGTPHFAPGNGMGSAKSGSSFKTALAGAALGTIGGLAAFELGKAIISSASTPIQHNNRDYYWGQEYHKQKAGEMRCSMPLNDLIQNVPTETTTPAPGATTAAPDATTTPPPNQLLSQLQFANGTRPKEIVWSCKQGTEVCCGTDCCAAPVQQNNNNPNGASSQGGSGSSIFGIILGVLLVIALLACCCCFAVYKLCRSSLDSCLPSSNRQEEHYYEDGQKYEGPAYGNSYPLQPTQYSNQPYSNQPYPQQQQQPQQYPPHPEQGYYNQQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z967</accession>
    <name>A0A914Z967_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z967"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8463.t1">
        <property type="protein sequence ID" value="PSU_v2.g8463.t1"/>
        <property type="gene ID" value="PSU_v2.g8463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8463.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48222" checksum="FA515CD404334B5E" modified="2023-02-22" version="1">MPFGLTGAPFAFQSVMNRIKSEVKAAIYCYLDDVVVVSESEETHLKDIAEFLQVMEMNGLKLRLDKCNFGKAQLKHLGFLISRDGIRPDPTNVENYFRRFIPNFAKIMACLHELTTRGEEVKKNWNETHENAFKTVIQKLVEAPVLVPPQFGRPFEIETDASKEAAGAVLYQRDNDNHLRPICYYSRKMNKHERQYSSIELEALAIVAALKEFRPYIEGSGTTIIRTDSSACCSLMKNKNLQGRLAKFQLAIMAFDIKFEHRAGVDNKFCDYLSRADIIKAIKFNVYPEDIEEKKLEMKMENLVMKNSALYFYNQEEADDIRLLIPYSLRERIIKEFHADATQGGHLGQLKTLEKMKKRVYWPFMVVDIKETIRGCATCQTAKVNPGDRVPEPLAPIEPPDYPFDRIHIDYFGSCCDVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9Q1</accession>
    <name>A0A914Z9Q1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9Q1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6975.t1">
        <property type="protein sequence ID" value="PSU_v2.g6975.t1"/>
        <property type="gene ID" value="PSU_v2.g6975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22966">
        <property type="entry name" value="DD_DYDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049630">
        <property type="entry name" value="DYDC-like_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172:SF4">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6975.t1"/>
        </source>
    </evidence>
    <sequence length="554" mass="62677" checksum="4967F733E4DB45E6" modified="2023-02-22" version="1">MIKVLQKSGGDAFIEDKYGHTPFYYRTHGKRLNMRTLKDNAVINQLISGQLNRPLLQGELKKCLKFMQIIVLDLEEDISDWIHTGNVGKLEELVLNGYADLLLGRNHQVDDADAVGFLEVLPQYQAKIQAIHRAIEQGNLRAVKLLTDRKKLALCRDGKGLAPLHKSIVFDRIDIAKYLIRNYPQSVNAMDQNKRTPLHYSAALRDGGYMYKLMRKSGADPNIFDCNGRPPKYYLKYPGEISLEQMRMDTKQALKQVLHNRVAPSYLETNIQQWLREGNLGKLDQLVLSGCGDLLLDKTTNHPDTQIFLKELPALLKTETIETIHRSIREGNVEKVKENITTKRLALARDKHGCTPLHTAIIYEETEIVRYIAANFSMVLNAPDYNKRTPLHYAAAARDGGHYMKILAKAGADAMAVDNEGRTPDYYRRNAIFDLKLMKERDDEVDTFQQSILDDAPAVDTPPSPDSGSACSSLMDSGRRDDEDDINGSRFEKLLQDKLDLPTSDNGLYLARTVAPVLTKALAEVLLRRPANPIGFISEWLVRYNDDEDNSIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9Y6</accession>
    <name>A0A914Z9Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9Y6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8735.t1">
        <property type="protein sequence ID" value="PSU_v2.g8735.t1"/>
        <property type="gene ID" value="PSU_v2.g8735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF10">
        <property type="entry name" value="3-DEMETHOXYUBIQUINOL 3-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8735.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16836" checksum="73F01C962A3297F6" modified="2023-02-22" version="1">MNMAQLQAEIAKHFPSRLGYVTPLAAGAFPLTRRHALQYVQPGLALVGDAAHTIHPLAGQGVNLGYRDVDALIDVLVNARSYGEAWASYPILKRYQMRRMADNFIMQSGMDLFYAGFSNNLPPLRFMRNLGLMAAERAGVLKRQALKYALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA32</accession>
    <name>A0A914ZA32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA32"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8645.t1">
        <property type="protein sequence ID" value="PSU_v2.g8645.t1"/>
        <property type="gene ID" value="PSU_v2.g8645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8645.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14379" checksum="B81E37DB805DABE5" modified="2023-02-22" version="1">MNYCYKYFSTYLSWSNSSSLCKNQGAQLLAIHNATQESYIETIYKSQIGMQDSLVWIGLRYFKLENPSYWGWSDGTLLGYAKWLSDDNYNECGAIQVLRNQNGWKSVSCDAKLPYICYQKAVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA35</accession>
    <name>A0A914ZA35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8783.t1">
        <property type="protein sequence ID" value="PSU_v2.g8783.t1"/>
        <property type="gene ID" value="PSU_v2.g8783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8783.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="9479" checksum="DDE23EDE3AEB1F2A" modified="2023-02-22" version="1">MESWVIAVIVCFSIFFICLICGAILSCAHPGYYGGGYGGGYSGYGGYGAGYGGGYGGGYCGQPGGVIVVGQPSYGQACATTPPPCAVINQRPSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAB9</accession>
    <name>A0A914ZAB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7195.t1">
        <property type="protein sequence ID" value="PSU_v2.g7195.t1"/>
        <property type="gene ID" value="PSU_v2.g7195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7195.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29195" checksum="3FD0B00CB0068747" modified="2023-02-22" version="1">MLHFTSQAAPPPSLVPAQPIEDVEIRRRKQTPPPTPPTPVTQATVNEEIKKKTQRLRKRKSQYTASEESRKRANKIQRQKDLGHRSQRKDCIIALSFKTDLQKLKRDKERAESQIQNHYSRVKLLSSEQLRKFFAAKTDAEVGATQLRRSREVVNALYKYFTKETVLERLIEGCTVYGITASFINFDNAAQFELFKQCLINSNATSTAHWDNVLSSKENWIEEFGIDYAFRVSAADKRLFCERNLLTDDEATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBK7</accession>
    <name>A0A914ZBK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7631.t1">
        <property type="protein sequence ID" value="PSU_v2.g7631.t1"/>
        <property type="gene ID" value="PSU_v2.g7631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF338">
        <property type="entry name" value="CYTOCHROME P450 CYP36A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7631.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22633" checksum="67CE357953C7DE81" modified="2023-02-22" version="1">MFDGDYGLIFNDNSFWREQRRFALHVLRDFGIGRPILEQTIMEQATGVCEYIKSFNEKPIELSKVLTTAIGNVIYQLAFGQTVDLNSNFIFDFRNKLIETALFFAHPLGFLCELWLPFRYLDPFFGGIYSKTMKRHFEMLDFMNLHVKEHRETINFEGEPRDYIDAFLMEQRKHANNSPEWILQLEPLPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBY4</accession>
    <name>A0A914ZBY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP complex mu/sigma subunit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9245.t1">
        <property type="protein sequence ID" value="PSU_v2.g9245.t1"/>
        <property type="gene ID" value="PSU_v2.g9245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9245.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15410" checksum="54C82F399412350B" modified="2023-02-22" version="1">MSCSAIFILDLKGNVIMSRNYRGDVELTQIEKFMPLLVEKEDEGRVSPILQNGNTSYIYIKHMNIFLVSLSKKNANAALILSFLYKCVEVFSSYFKDLEEESVRDNFVVIYELLDEMMDFGYPQTTEPKILQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD80</accession>
    <name>A0A914ZD80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZD80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g822.t1">
        <property type="protein sequence ID" value="PSU_v2.g822.t1"/>
        <property type="gene ID" value="PSU_v2.g822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18160">
        <property type="entry name" value="REC_CpdR_CckA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000083">
        <property type="entry name" value="Two-component response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF046022">
        <property type="entry name" value="RespRegCpdRBruc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF21">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g822.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13636" checksum="757AE749A354188C" modified="2023-02-22" version="1">MKRILLAEDDNDMRRFLVKALEKAGYHVTHFDNGASAYERLREEPFSLLLTDIVMPEMDGIELARRATEIDPDLKVMFITGFAAVALNPDSHAPREAKVLSKPFHLRDLVNEIEKMLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDY0</accession>
    <name>A0A914ZDY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF38 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDY0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8483.t1">
        <property type="protein sequence ID" value="PSU_v2.g8483.t1"/>
        <property type="gene ID" value="PSU_v2.g8483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8483.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29572" checksum="8A66CEDC9F4E5CC1" modified="2023-02-22" version="1">MSLNFPFPRDVMKRILATENPYIVAKLYKTCKYFPAKFNLILVDSLRHTFRQDVISHEDKATNVNPENVDSFQNLWVIHRFISVTNDPRLSSWISNISRCTIYYLEIRARHLTMNEFEILTNSGNIEHIEINKVYYDNFTTVPLEILVSRIPKASFIAVDYTHVTPSTMKILAESTHETKITNMSLRNIDDIMDDEDYYQFMRKYAEREAQFFVQYEGIPEEYAQKFGTSVKFKNFISKDANPKPHFSYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQK3</accession>
    <name>A0A914XQK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XQK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10287.t1">
        <property type="protein sequence ID" value="PSU_v2.g10287.t1"/>
        <property type="gene ID" value="PSU_v2.g10287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10287.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23334" checksum="8FBDA73BFBBEDB18" modified="2023-02-22" version="1">MLFLLKMIYQDKLRLTSADITEEDFAFLKSKNKVLCNLEECSIKSNFSPSIYSSSSSNSQNSSPIFLSPFPPNPIIRRDLSQSQHPRKRVPNRSNAKKIAKISPLIKRTYRKSYNHNNDENFPKIIVPRPRKQPPPLRVSSLDISRGFVGFCGVLNVNPYYAGCPGRITTTKDVIGHTYFICANCGTRRRYLEESSSKTNVLNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRY9</accession>
    <name>A0A914XRY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XRY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10755.t1">
        <property type="protein sequence ID" value="PSU_v2.g10755.t1"/>
        <property type="gene ID" value="PSU_v2.g10755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10755.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="22009" checksum="E9A366DEAED3659F" modified="2023-02-22" version="1">MMLPPGVQGQQQQQQMQMPPPPQPQQQHGMPPPLPPGGPQQQPGMPSSQPQQQPQQQQQPSSAQPQQPGRPPMDQTSFEEHQRQMIQQQQQQRPKSRAKSKAPTPQPPPPPPPPSQTSQCSTAPGTSEQQQQPPQSSKPQTPAAQPPPPPTSGAASAAATPTPVATSQASSVSQGSGTPQPPPPATTSAGPNNLPPQTSIASSSSESGNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT28</accession>
    <name>A0A914XT28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1112.t1">
        <property type="protein sequence ID" value="PSU_v2.g1112.t1"/>
        <property type="gene ID" value="PSU_v2.g1112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1112.t1"/>
        </source>
    </evidence>
    <sequence length="599" mass="67083" checksum="EF80754AABFCCEDC" modified="2023-02-22" version="1">MSKKDDRRTSILKPFEENVPEVNKTKRRVSFHTHRTVKEFNKADMGGDQTPKNESIHYSGSSEEKSSFFGGNRPGSALTYTSHQTTDIVMNDKDFTMNSTANVTMAMFDRVAKRESRAIDDDATNVVDPTIAVFGNLIPFSTPIRNTTNYQEDQTLAFIEKFVPTERLTPEVRASPKRIAELYEEITCPIHISSPTSDKNPYNVDEDVAKAFKSCQLSPVKHRQEAGGGSLEFDLENDDHYAAEELLDGNKTLTMPQRSSSSPTSHALPMNSTYVVTASSVEGMYLPDESETINPISDPSKDKTYVVDQMKDDDIEMNDTSRTSSTTNSFHAPQHSEITKKKFRRLSDIINREKRRSSILSAAASSAANSPAIPEETAQQPSTLTVVNATINLSIAKSTINKSVANCSLDVFDEPMETTEAVSSEENVDDSLNQHDSVFENTFEQKPKQRNNTSILKNGTMLLEDVRTPTKYLEDSNFTIPVPPCDESFPTVHQPNDSEKLQKSDSNKSVISQKSVLNQTFEVQSEVSKIMPNGLPAIDKRYIRKEEAPKVNQTPGWAKYSKCLEIMKKMSEKEKKEQAIAMEDFDEEPNYLHGDSYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTK2</accession>
    <name>A0A914XTK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10295.t1">
        <property type="protein sequence ID" value="PSU_v2.g10295.t1"/>
        <property type="gene ID" value="PSU_v2.g10295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8206" evidence="1">
        <location>
            <begin position="329"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10295.t1"/>
        </source>
    </evidence>
    <sequence length="563" mass="64445" checksum="559B1B9AC2D19E10" modified="2023-02-22" version="1">MESYRQINILLIGLTGVGKSSFINSFANYLTYQSIQEAIKADKPICLVPTYFEYTDSSIKAYPVRISANDDENEDFTCASNSSTQSPKIYTFRFKSENLEINIMDSPGAADTRGFTMDKQNIQTILDAVSTFSQLHLICLLLKSTEPRLTPEFQFGLNELLMHLHKNAVSNLVFVITNSRASNYSLGHVSAPLKDYLKKLKKSSNIKIELNQSNVFCIDNEAYRLQCLWNQYPKLKDPSQMATVEGSWKTSFTAIKALIKRGLEINAHDVAETVSLNEARSAILLLNDPLTKIYVILQTCVKNYDKNQDAISVGIINNAHRDLDIKVRKIKAPKTICTKCSLTCHQNCKLRGIRIKSQVDEKLRDCASFDRETGICFKCGCHYKLHMRELYETEKTYRNQNFVDTVDGGSETTQKNIHEKLDQVIEELSKEKKMIEEALEKFGTFLRNNAILEYNYVLENRLELEIKLAEGNGDYKVATLTKEMLEKYKTQKEQLIDAIKSGKKQKEIITSQSIVTEIREKLFEMKFYGKKIEELYEIQLKLSQADIIETDRIEYDAIIPITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTU9</accession>
    <name>A0A914XTU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTU9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11383.t1">
        <property type="protein sequence ID" value="PSU_v2.g11383.t1"/>
        <property type="gene ID" value="PSU_v2.g11383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11383.t1"/>
        </source>
    </evidence>
    <sequence length="561" mass="64776" checksum="DFE7D13DC8F861A8" modified="2023-02-22" version="1">MLLQDHFVRTFYDVVKATHPVIMVNVDVDALCALMILSNCFNMDDVQYTVVYVDSPASFDTRLRSFGDVGKNIILINCYGHLSFEEAELPGQHKFFIIDSRRPFHLDNVFSNHISILTYSKEMTSWNLPKIEQVYMESDSSSDEDDGGEDRELMVQQRIIRNAAKAEWSRKRADIIWDYYARTWYSIPSAVLLLELAHSMNKSNANFAWCAAVALSSQFTDNLISFDQYASICTDHMKQFVLKFGQKQKNCGDLMNITFDEEILLPLYRKWNLYSAMTHDITFCCQNAFWNQKGENVLKHTISELGIALDEVHKSFDSLPSSRRKEIFDILNKYLDSKFVTFFAQYGYHQKFTAVDFARIMASKLELKLATANHDLIKRVESAKKLLTTFFENNGHDTSIPPAIALYQKGLDAVRGLVFHALLHSQVTAAAENFYVLTLDSSQDIIYLSSRHFLNMFVHFILTGFAISKNKKRSSKPIIFLIPSMTNDENRFWTITGAMPYIDMVRETERKSSLPIAFKKVTENQHIPITRDSFDPNILQIRHEDKVKFVEHLDVMLENFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU39</accession>
    <name>A0A914XU39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11472.t1">
        <property type="protein sequence ID" value="PSU_v2.g11472.t1"/>
        <property type="gene ID" value="PSU_v2.g11472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11472.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18117" checksum="3CBC257415096575" modified="2023-02-22" version="1">MECCIRMRILGNSESCPQCRSPITLLYFVSAPESWDDFTIPTGDITHDDSAKYNIRFTTDYTVKCYDSYLAHSCHICAQNGDKIEFKTFGALRHHTSQMHQRTFCSICIEHLNVLSKDRQAYLKNELDNHMRGTSNEVSGQKGHPPWYFYFNIFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUB0</accession>
    <name>A0A914XUB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10123.t1">
        <property type="protein sequence ID" value="PSU_v2.g10123.t1"/>
        <property type="gene ID" value="PSU_v2.g10123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10123.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21727" checksum="6B13F9E5C262426B" modified="2023-02-22" version="1">MIMTAHRTQIKTRFSRHHRPRAVVSSVVCTGTARIVYNAASGMLKGSVVDSCDNNFAVNGVLHQPFSIDEPSTSLADFFITDGDDGSQFSVLNIPVEWLPIVNVVTKATHYHLRISHATIRFETKELLIGNRADLEIAQHLGAIVEREAGERPSVHLGPMTIKIVASQRTEPGFRRESLCENHSVPIVEQSEDFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUK0</accession>
    <name>A0A914XUK0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="1">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUK0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10924.t1">
        <property type="protein sequence ID" value="PSU_v2.g10924.t1"/>
        <property type="gene ID" value="PSU_v2.g10924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10924.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37826" checksum="6AE15D47196118F3" modified="2023-02-22" version="1">MRTKDRIGDMEVNLFLLPSAVNDGTSRIAEILKIDEKMAEFEAKFAEEASKFSSQNQGAAKLELMRRKKRQELFAEAEKTKSTDSDAEILWKINFNILDRIYRDQLLLEILINDVGIDDIGEKIMRAAFGFCLKLQDGNASQPCAKFFSRKDLEVVLRNNADITSDDYEATLYLVSSSADRFIRKVGEGSGGLYTIDYVDGMRMLLVRILKSMIQSKYENPNDKDEEKRGFPTFIFTLLLKKGLVEEEKLAETFKHPENEVRQELFRLRNDGFINVVTKDTSYEFNPMSSQFLYGVDLLKVNLNQFQKVLQYQIIFIVALKKKKKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUK2</accession>
    <name>A0A914XUK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Suppressor of cytokine signaling 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11627.t1">
        <property type="protein sequence ID" value="PSU_v2.g11627.t1"/>
        <property type="gene ID" value="PSU_v2.g11627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF0">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING AT 36E, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="236"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11627.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33377" checksum="C5A7820714510040" modified="2023-02-22" version="1">MISGGSKKKVKGRRTSRNPALCPFSPPVSVSGSEDDEPKPESSNAFFRVARELCSRFTSSTESSSQPSSSSSTVATTTAVTRRSTTTTTTTTNEAAIINTFTEILSNPSLGSPSERAEIACNVIHSTVEYTNILVPDMISITAATYYWGMMDRYEAERLLEGKPEGTFLLRDSAQINYLFSVSFRRYQRTLHARIEHINGIYSFDIHDDAYHRAEKIKDLVENYRDPKQCLFYEPQLSLPLKRDFAFDLKHLCRAVITAHTTYENVSTLPLPPPLKKYLREYHFKQPIRVTDHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUW1</accession>
    <name>A0A914XUW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUW1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11730.t1">
        <property type="protein sequence ID" value="PSU_v2.g11730.t1"/>
        <property type="gene ID" value="PSU_v2.g11730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11730.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8412" checksum="AA6E4DB3004F732F" modified="2023-02-22" version="1">MVTVLDNEAIEKNAMAKMHIKDPSMKDVNAIIGRIMAGITSPKRFGAPNVVSLFNLSSQLCPVSPLHFIQCGKILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVD4</accession>
    <name>A0A914XVD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute-binding protein family 5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVD4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11193.t1">
        <property type="protein sequence ID" value="PSU_v2.g11193.t1"/>
        <property type="gene ID" value="PSU_v2.g11193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08504">
        <property type="entry name" value="PBP2_OppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000018">
        <property type="entry name" value="Oligopeptide ABC transporter, oligopeptide-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.105.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290:SF10">
        <property type="entry name" value="PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Solute-binding protein family 5" evidence="5">
        <location>
            <begin position="64"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11193.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35281" checksum="7AE9B02107249AE2" modified="2023-02-22" version="1">MAGNVALAADVPAGVTLAEKQTLVRNNGSEVQSLDPHKIEGVPESNISRDLFEGLLVSDLDGHPAPGVAESWDNKDAKVWTFHLRKDAKWSDGTPVTAQDFVYSWQRSVDPNTASPEKPITDLGVKAIDDHTLEVTLSEPVPYFYKLLVHPSTSPVPKAAIEKFGEKWTQPGNIVTNGAYTLKDWVVNERIVLERSPTYWNNAKTVINQVTYLPIASEVTDVNRYRSGEIDMTYNNMPIELFQKLKKEIPDEVHVDPYLCTYYYEINNQKPPFNDVRVRTALKLGMDRDIIVNKVKAQGDMPAYGYTPPYTDGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVH8</accession>
    <name>A0A914XVH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11236.t1">
        <property type="protein sequence ID" value="PSU_v2.g11236.t1"/>
        <property type="gene ID" value="PSU_v2.g11236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11236.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8156" checksum="8D2915377923359F" modified="2023-02-22" version="1">MWYEQFYSGFITLAFVWGACNISAVTNYADLGRLYRRDLSGYDRNMLLKRDHRLTGNYYKMSGLESIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW15</accession>
    <name>A0A914XW15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12126.t1">
        <property type="protein sequence ID" value="PSU_v2.g12126.t1"/>
        <property type="gene ID" value="PSU_v2.g12126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12126.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30866" checksum="68F9951C07F8D0DB" modified="2023-02-22" version="1">MIIAELNLKMKAENTKQKEIEDELRAKVVELEQKYMFSSQQYQSAKNTIDELTVLITDIKERMAIFGQKESENIAKIERYEKSIVLLQKVVKIHKKNISKLNIKQESDKPESYVPAKTYAIDEPQNFSFFKLLQNDKEKVDESIFQKMDEILIDSIDENPLQGRIMVVESICPLEDEDSWEAYSNFDCTGKPVKISLKKDTPKFMLQLNGRLNVCDAEIDVNSLLSHLHSCHLKDLRLVDQKISENDFIKLVSSKALEKFIFIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWZ6</accession>
    <name>A0A914XWZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWZ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12469.t2">
        <property type="protein sequence ID" value="PSU_v2.g12469.t2"/>
        <property type="gene ID" value="PSU_v2.g12469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP binding protein second" evidence="3">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12469.t2"/>
        </source>
    </evidence>
    <sequence length="193" mass="22303" checksum="2793BEBCC304296E" modified="2023-02-22" version="1">MLDAKKGEQQKILLERELEAVGIRLNKPRPRIYLKRKAGGGVKVNHTVPLTKCDEKLIMTVLHEYKIFNADVIFHDDYTIDDFIDVIQGSRVYIRCLYCYNKCDHLTIKAVDTLARQPHSVVISCELNLNIDYLIETIWDYLALIRVYLKKPGNAPDLGQEDGLILHNDSTIEQACHAIHRTLAANFRYYLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX39</accession>
    <name>A0A914XX39_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">adenylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XX39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11099.t1">
        <property type="protein sequence ID" value="PSU_v2.g11099.t1"/>
        <property type="gene ID" value="PSU_v2.g11099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006225">
        <property type="term" value="P:UDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11099.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26847" checksum="66D7F385813F6647" modified="2023-02-22" version="1">MQRKLATNCSISFWPPTRKKISNDIQIKKIIFFANNTINRVKIDLAPLKAAKLPVFFIVGGPGSGKGTQCDQIVKKYGLTHLSSGDLLRAEVQAKTKIGTECKAIMDKGGLVPLEVVLDLVKIAMLEAVKKGSKGFLIDGYPREVKQGDQFEAEIQPAALVIYFEASNETLVKRLLERGKSSGRSDDNIDTIKLRLDTFFNSTRPVVDHYSKKNKLVKLSAERSVDAIFADVCVQLDKHVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX52</accession>
    <name>A0A914XX52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX52"/>
    <dbReference type="SMR" id="A0A914XX52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10331.t1">
        <property type="protein sequence ID" value="PSU_v2.g10331.t1"/>
        <property type="gene ID" value="PSU_v2.g10331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000050">
        <property type="entry name" value="Acetyltransferase YhhY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007527">
        <property type="entry name" value="PRK10140.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072">
        <property type="entry name" value="N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10331.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18794" checksum="F7565FA6906418E4" modified="2023-02-22" version="1">MSEIVIRHAETRDYEAIRQIHAQPEVYCNTLQVPHPSDHMWQERLADRPGIKQLVACIDGDVVGHLTIDVQQRPRRSHVADFGICVDSRWKNRGVASALMREMIEMCDNWLRVDRIELTVFVDNAPAIKVYKKYGFEIEGTGKKYALRNGEYVDAYYMARVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXY6</accession>
    <name>A0A914XXY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11817.t1">
        <property type="protein sequence ID" value="PSU_v2.g11817.t1"/>
        <property type="gene ID" value="PSU_v2.g11817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11817.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="21860" checksum="0EB284CC32CAC9B6" modified="2023-02-22" version="1">MANPAPSVYKSAADTHKTIYFTLAIAVNLLGIACLLIAWNAKGINNDNLFWAMLLVAIVAGSGILVCCFAVFFLCRPFQSTDTSKRRIFDVQTVYPTPEFQYFTNTMLNRAQNKLSSRGSDFSVVSTAPAGSPVGHNTDDASVLNFATLPSNNNLNNPLSHSQQQTTLTTTTCTGDSLELSLESAFTPSSRSSHPSNHSNSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ51</accession>
    <name>A0A914XZ51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ51"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13223.t1">
        <property type="protein sequence ID" value="PSU_v2.g13223.t1"/>
        <property type="gene ID" value="PSU_v2.g13223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13223.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="14240" checksum="31A939482750A64F" modified="2023-02-22" version="1">MLKAIESINKQLPPILNAIENSVLAANETYAKIEIALGQISLPCYIDNCGKTTQAPETTAQTASTDVTSSSGSSAEPGSSTVSPGTTEAPFTGSTPSPGSTEASSSTVTGPTEATSTGGSGSTETTLVTGGAGTASTSDATASTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZU3</accession>
    <name>A0A914XZU3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZU3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12047.t1">
        <property type="protein sequence ID" value="PSU_v2.g12047.t1"/>
        <property type="gene ID" value="PSU_v2.g12047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
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        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="5">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12047.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27521" checksum="8758A7804C0AAA5A" modified="2023-02-22" version="1">MSIGLTESQLDAALDGVDISDGSFGAHDGEEVIDLEEAIKRFKQAWMNENASPKLLSSQYELVHAIVQQIDEFEAFTANYTQQQKLDLSYNIRRMEISRLQYIINSYIRTRLRKIEKDPVGILKEHEDRINGVSTSTEELLEEKEVEFAENYFESSRKLLLDEFLGSLAQCLQKVPRITETNSTARVFFEVIVDNCESITVPKLKDKELEFIVPLAKGDRFLAPFKCVEELLEKGHIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y161</accession>
    <name>A0A914Y161_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y161"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13941.t1">
        <property type="protein sequence ID" value="PSU_v2.g13941.t1"/>
        <property type="gene ID" value="PSU_v2.g13941"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13941.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25188" checksum="65D39938E6D85D10" modified="2023-02-22" version="1">MVELINESNKIRDHYREQATHHQHEIEEQTTRAERAERNPNPNPSSQLPQLIPIPSQYYLPFPTLPLQQPGQIPNNLQPNQHQQQYSNDQDFDGNTSNRHNHHNHNHNHNDNRYDRNNHNRKGSPRNPGEITHGEENRPNNDRSNRDNQIPPLRRSSSSDYERDEFATDTTDSKEFGFDRTQSHLAADHPARTLPPVDILLLIDASSSIGNNQFEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1K7</accession>
    <name>A0A914Y1K7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
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    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1K7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12667.t1">
        <property type="protein sequence ID" value="PSU_v2.g12667.t1"/>
        <property type="gene ID" value="PSU_v2.g12667"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12667.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24470" checksum="D0C96A47C96F781A" modified="2023-02-22" version="1">MDSIKQIIQNVGLVKSSNNSNNKSDVNLTKSEALQRTAAALEANDSSNLTPLEQQFVDLARISTAKDSIIETQRAEIRKIHDELHALKKKTKEVKEELQRSELRCRAQDEELTMLRNLGKEQTYMCDRVNDLTKRLVEAKDETDKITAELNAKIELEITKATTLEKESNEKSLKITEFEAILGRIQHENYDLKKDLEISDAKLIEQKREFRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-06-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1N5</accession>
    <name>A0A914Y1N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g11733.t1">
        <property type="protein sequence ID" value="PSU_v2.g11733.t1"/>
        <property type="gene ID" value="PSU_v2.g11733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005564">
        <property type="entry name" value="Major_capsid_GpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03864">
        <property type="entry name" value="Phage_cap_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11733.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13829" checksum="D7A46E4BFB8E5906" modified="2023-02-22" version="1">MADINIFQDEVFSVPNLTAAINETLHVPGRIGALGLFAEEGISTVVAQIEYDGQTVGLVAAKPRGSDGSTVTLSGRRVIPINTVHLPERSTMMADEIQGIRAFGSQSELETAESRVXNTWRSTVFSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y215</accession>
    <name>A0A914Y215_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y215"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13276.t1">
        <property type="protein sequence ID" value="PSU_v2.g13276.t1"/>
        <property type="gene ID" value="PSU_v2.g13276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13276.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25663" checksum="F48FB50BA14F1053" modified="2023-02-22" version="1">MGNSLSSGTSSNDNSQQPTPNSTINQNYLAARLSGLSLGNGEQNYNNSANNLHDSSLLHLPSTSSNNGNNQGPPSLAAAANIAARQRLIEELQYLAQQRYIDEVTINYNLNNQGTYADIAATDGDGDGGDVEDNSLLAYIEMPEESNEIMASNNLRRSDPQLSRHSSNTSIHQHLQHQDQSNPEQNDIFNINIQNDDINDNSSDNEDDDNSYSGISLFQRIQISLLRRQQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2C0</accession>
    <name>A0A914Y2C0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2C0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11948.t1">
        <property type="protein sequence ID" value="PSU_v2.g11948.t1"/>
        <property type="gene ID" value="PSU_v2.g11948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11948.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7484" checksum="9B33D60F268BE4B7" modified="2023-02-22" version="1">MCAAGEFACIVSEQCISSGARCNGVVECDDGTDESNCEGCGQGFFHCLKSSECVPISQRCDGTPQCTHGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2C5</accession>
    <name>A0A914Y2C5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2C5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11952.t1">
        <property type="protein sequence ID" value="PSU_v2.g11952.t1"/>
        <property type="gene ID" value="PSU_v2.g11952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11952.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43746" checksum="ACFBD3DB342AE01D" modified="2023-02-22" version="1">MLSPSHSLERFDEDSKFSKVSMSKTLEILDDFQLNNLITVVAEDFRLKCEMKAQLRQKEMALSEYGYHHRGRNDGCAFCCQNFHMFHRSVTCQRCSRSVCKNCCKEDKICNFCHDLQILEYRKREWSVLCPFRGNTFGYAKMVANDLENSYFIEWTIKAKLELHLVHLLADDLDNADVCFSVSDTGLELIRRQLMMALLNYSNASHFAFIDDSILEAKKIIQKRSNCIQEAKIPVESFSYFHLLSNAVISILVNAASPARNKFAYLSKSHEIRPLFPPINDEDLQNIDYTGVTPLTLNSNWFLKPKFISPRGSMRSQMSSHLVNSIVTPDFFKYGISTEEKFMETSDDEQLLNVSSILDSESGYGTWKMSDANSKPLRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2E3</accession>
    <name>A0A914Y2E3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2E3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14341.t1">
        <property type="protein sequence ID" value="PSU_v2.g14341.t1"/>
        <property type="gene ID" value="PSU_v2.g14341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14341.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12973" checksum="A1814CEE3D07A6FB" modified="2023-02-22" version="1">MILAVCAASYFVLMGILQLYLWYIEKSIFYQAIEKDGKAKDRYWKWSSDMKRFDDKYTLTASYSQGDSFGKVSMSKSMGQYISEDGLILLPSLKAEIHELYNRALKNAQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2Q7</accession>
    <name>A0A914Y2Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2Q7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13525.t1">
        <property type="protein sequence ID" value="PSU_v2.g13525.t1"/>
        <property type="gene ID" value="PSU_v2.g13525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043843">
        <property type="term" value="F:ADP-specific glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF0">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13525.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17627" checksum="C2150A43199A6A51" modified="2023-02-22" version="1">MLYWLLTTFGHDREKSDSPNFYYRLQRIHFHCLTYHIVVSRGTDWSNLAAGLAAGARLAGRQSCNLHSYKGESDLLEVRTASRTLLDKKMDKVYEFDPHNPLASWMRNDAIFIYTPVLVCKFPLHTVGVDDAISATALLYSQFYKIEKFHGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Q6</accession>
    <name>A0A914Y3Q6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Q6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13863.t1">
        <property type="protein sequence ID" value="PSU_v2.g13863.t1"/>
        <property type="gene ID" value="PSU_v2.g13863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13863.t1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61856" checksum="205A08B44E3AA5C2" modified="2023-02-22" version="1">MLRSLQNSSPEDEWLKKSIDQLKSGIPFFVRFVGKIELPRSIAEEPAPDNRVEIICGCLRKVAQAASILDESFNIPDIAQRNAKIYVKNVEVQLSVYDNVFTIGDHVTNKFYGRHKIGDIAFAHLDSETKNIFGYYALERKVGKPDTRFYYVIQSDCGMQVLAAMKLAFTVYAEKQENNGDIDVFKIAESMTPSPSTPSGSYCLLRLSTPSSDGTGFVHQITPIDSERLHQQVKMMALSDRLEACMLQSGIMNSTTAIQNITNVYLNMDELRLINPFASNQVFPPVSEIPETLKPKKPETKKIFEVPEFSESHENDDDDFLFGEDCVERFETVPPIPFKTAKVLARLQQICDENCRVYSAPPPPSFQPLQHFYTHPPNPLQNPLHHPHHVRRSRREDINNYDDEIERLKRKERDLQERIRQVEIENQKAQQIPEIPALPPRRKRRVKFRSIKEAFQFRAQKLALPFKKRLGNLRLSDYDESVLASEYASLNSQSFDGSISTSDTSASDASSQDSGVHEDLFVFPEALENSLHWTNRLFRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3R1</accession>
    <name>A0A914Y3R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3R1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1387.t1">
        <property type="protein sequence ID" value="PSU_v2.g1387.t1"/>
        <property type="gene ID" value="PSU_v2.g1387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1387.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13075" checksum="66B5E8AA12BFE486" modified="2023-02-22" version="1">MNLKEKTCKVCERDMDETDEEFCDDCYDCFIGWFDSMTFTGCKKSRDCINGPAAELINCDQCRVKKCIKSGMKLPDFMMPPISAPSVQIRPEYLTSLMASLMSFNNPSLAQNNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4G5</accession>
    <name>A0A914Y4G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4G5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15097.t1">
        <property type="protein sequence ID" value="PSU_v2.g15097.t1"/>
        <property type="gene ID" value="PSU_v2.g15097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15097.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17099" checksum="1B611CB201B98AE8" modified="2023-02-22" version="1">MKQRDHQGAANELFESMKDGNEKRRKRRQADFSDDYGSDVYGYGRMNRQFDSPNDFEEDGERRGPPSFGFNGQQPGQRQGPLQQFGPFGRPRHGPSFGPGNDDDQRQGLDGRRGRQGPPPSFGPGDEGHRGPFGPRQDEQQVMMMIKDKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4J9</accession>
    <name>A0A914Y4J9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aquaporin</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4J9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13698.t1">
        <property type="protein sequence ID" value="PSU_v2.g13698.t1"/>
        <property type="gene ID" value="PSU_v2.g13698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13698.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7502" checksum="9983E722D7C07382" modified="2023-02-22" version="1">MVEQVTWVDRVRVKATLKHDIGRTALAEFFGTLVLVLIITSVVAQNVLPKAGLGNALIGVNVGVACGMLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4L1</accession>
    <name>A0A914Y4L1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neogenin C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4L1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12663.t1">
        <property type="protein sequence ID" value="PSU_v2.g12663.t1"/>
        <property type="gene ID" value="PSU_v2.g12663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12663.t1"/>
        </source>
    </evidence>
    <sequence length="405" mass="42503" checksum="0AB243D1D014D1DD" modified="2023-02-22" version="1">MGELEGGTVLRDFRHHDSGAVDSPPPRYQTVQVSPIMTQSHPSPSSLMIDNTPLRQSLRRLHRQSLPPPANHHHSTTNPPTKRVVYVCETPYSAAAEDSDSAIVGSRTSSRNGLQPSTPQKRSPIKRLSLAREGSAGNAGTGSSAYVSDADSNGTISRSYHHSSASLEGRQRTPQIVYTGTNRQPITKIDFSSDHASSYGGSSTALQNQTPPPTVTDSGGYRTIRGPGTNPLKSFAQLGAGPPPISSPSHGSHGFPISAALISGLHGEQRTAQIVRPTVVAPASNRSSPLNTQKQFIHHQKGGGSGGGGPLGSSIGKLPIGRAAAQPRINMSGAYSPYASTRDVCGGLIGGNGGGNGDLDEIMSDQSENSTHKTLQSDFATDDVALGIDQMMLQLQELRDGFAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4M3</accession>
    <name>A0A914Y4M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HPr domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4M3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14390.t1">
        <property type="protein sequence ID" value="PSU_v2.g14390.t1"/>
        <property type="gene ID" value="PSU_v2.g14390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="entry name" value="HPr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050399">
        <property type="entry name" value="HPr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008146">
        <property type="entry name" value="PRK10897.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33705">
        <property type="entry name" value="PHOSPHOCARRIER PROTEIN HPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33705:SF2">
        <property type="entry name" value="PHOSPHOCARRIER PROTEIN NPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="HPr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14390.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8266" checksum="7BA858B088B403E6" modified="2023-02-22" version="1">MHARPAMKLFELMQGFDAEVLLRNDEGTEAEANSVIALLMLDSAKGRQIEVEATGPQEEEALAAVIALFNSGFDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Q0</accession>
    <name>A0A914Y4Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Q0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12697.t1">
        <property type="protein sequence ID" value="PSU_v2.g12697.t1"/>
        <property type="gene ID" value="PSU_v2.g12697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12697.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18067" checksum="1AEB528EC62C480C" modified="2023-02-22" version="1">MDPSDRMNVNESFEHIFIKTYFPKTTTERVCPFKVKLDMAAVEDIDHKQLINLIEADIRSADEQQQKNNEIISSDETQEIATSIEDDNDNNNSINHKSSTSGASSAASYYSMTSSSESQAESCYDPTHSLYDADRRSPRRQKNHQSELESSEVPPQITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y566</accession>
    <name>A0A914Y566_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y566"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13914.t1">
        <property type="protein sequence ID" value="PSU_v2.g13914.t1"/>
        <property type="gene ID" value="PSU_v2.g13914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08637">
        <property type="entry name" value="DNA_pol_A_pol_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000002">
        <property type="entry name" value="DNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF27">
        <property type="entry name" value="DNA POLYMERASE NU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="9">
        <location>
            <begin position="40"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13914.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31790" checksum="335ECBF57A841C9D" modified="2023-02-22" version="1">MINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLETVTSEQRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYLPDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQIHQLMENCTRLDVPLLVEVGSGENWDQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5X9</accession>
    <name>A0A914Y5X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5X9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1417.t1">
        <property type="protein sequence ID" value="PSU_v2.g1417.t1"/>
        <property type="gene ID" value="PSU_v2.g1417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1417.t1"/>
        </source>
    </evidence>
    <sequence length="708" mass="80378" checksum="8151A334E7204968" modified="2023-02-22" version="1">MFWIIEGHCISSYEHFASLNRLFAELSINKKKFTVFLDSIPALKNEFNILSEQFVARYNAKYTILPCKKFEDEVIVECSMDAGVEVVLGELQYYEDRNSSECPLTDTLLSIIGGCLKENKRMIVICGNDAEAKDIAERIDTEFRHILLEQELPNSRTAISVSLKLVGGVVYAANNPFYDKDDGFIPYIISKNFLIVVGSKKRLLYTGYEADVVINIIFTGSEKAMLDSEYSALFNLTIDQNSSVVTLTDSVVNAFSRFNYQPRLFNRTIINLINNGSIKNMDQLGVYASNCFINNFDFTEIVKELSKNGAVMEVNGEFEILGCKYLSGFYATEKRRLLSEALSSLNLKDILYLFFLANVYFVDASETLTLPRTCINSLFADSEVKVLCERVKLHDPRIRGNHYMKLESSIVISSILYKYFQNVSGIDIFTWVNDIDRLNVYLVINQQNFRKTFAIAQDLSSSFATIFKHLENICSQFNLSSLKQIHGLDFETVDLLISGGIKSVRDFVHSSNLETYLRSLANKREITVRQLYQDLRTEALSLQKPRKRLSLNTSGNTSRDIFSASNVGEEIVFKSLCVQNVSTLNEIFALPINDSVAHILHVRDSDYLTILRIDEKKVTVFEQVLNCCDLCEKEERMNEILKICNKSNIFVTNIFDASESFATAENPFDIILKANCLTAFAYVIGPNDISVFAKDWQKIHGNICIIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6G3</accession>
    <name>A0A914Y6G3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside efflux pump</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6G3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1504.t1">
        <property type="protein sequence ID" value="PSU_v2.g1504.t1"/>
        <property type="gene ID" value="PSU_v2.g1504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2090.10:FF:000001">
        <property type="entry name" value="Efflux pump membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1430">
        <property type="entry name" value="Multidrug efflux transporter AcrB pore domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1320">
        <property type="entry name" value="Multidrug efflux transporter AcrB pore domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB TolC docking domain, DN and DC subdomains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063:SF32">
        <property type="entry name" value="AMINOGLYCOSIDE EFFLUX PUMP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82693">
        <property type="entry name" value="Multidrug efflux transporter AcrB pore domain, PN1, PN2, PC1 and PC2 subdomains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="Multidrug efflux transporter AcrB TolC docking domain, DN and DC subdomains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1504.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16242" checksum="6ECBF47D317BFAB8" modified="2023-02-22" version="1">MRKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYVASNIQDPLSRVNGVGDIDAYGSQYSMRIWLDPAKLNSFQMTAKDVTDAIESQNAQIAVGQLGGTPSVDKQALNATINAQSLLQTPEQFRDITLRVNQDGSEPLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y889</accession>
    <name>A0A914Y889_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y889"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15493.t1">
        <property type="protein sequence ID" value="PSU_v2.g15493.t1"/>
        <property type="gene ID" value="PSU_v2.g15493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="67"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15493.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38045" checksum="49F04908ECD27C3D" modified="2023-02-22" version="1">MQKARAGSKYELKLHFWKLGAFELNTDFDLNLRKPGHKSSALHHWSKAPKKAFSKSHILVPFYLRHKSRPPTPWNTIRQAKAFGSACVTLPKFSPITASEDCLFMNIIKPAASSPNSKGYPIMLWIHGGGFLAGSAADYPYNATADRIVENGVIFISINYRQGAFGFFSTSDSKAPGNYGLWDQVQALKFIKKVIKKFNGNPKNVTIFGQSSGAISASLLSLSPATNGLFHRTIVMSGSSNHRFELMNKNSNESLQLSNILNCGNLTNTKVCLKTKTTAEIQNAMASVIQYLFGGDSTPLTGFIPRVDKDLIPNISYEKLIKRAPKRDIFIGLNNQEWYVFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8H0</accession>
    <name>A0A914Y8H0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8H0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13886.t1">
        <property type="protein sequence ID" value="PSU_v2.g13886.t1"/>
        <property type="gene ID" value="PSU_v2.g13886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944:SF1">
        <property type="entry name" value="CPG4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944">
        <property type="entry name" value="PROTEIN CBG02791-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13886.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17693" checksum="B410324CF3219944" modified="2023-02-22" version="1">MLQNFKHLALNGDSTEAEAYLSKSCEYVICTLHCDVPAIAHKCDFETADLVINLTRKSFASMERLALDTGAVSKWPTMCSDIKTYRLPKPGDIKDQPLPPTSIDEIAASGPIHQARAAATATSSSEAIAETTTTISQKSDATKISGNTNLLSFILFLVALIFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y912</accession>
    <name>A0A914Y912_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y912"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15246.t1">
        <property type="protein sequence ID" value="PSU_v2.g15246.t1"/>
        <property type="gene ID" value="PSU_v2.g15246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="158"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15246.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="57555" checksum="94062133ECA45D62" modified="2023-02-22" version="1">MERMGPKLADTLHSYNAVLPHIRHQNISDIIRSLNLTEQNPILKAFGISVQSTFSVIPPSKMWRPAVQMGSTVAQPKDDGSFRVNSKYLVPATAGKWAVFYGDRGSRLDTVKTLVQRLCSEAAAKGMKLPPPTLIQSVDMANFMTKAFVNIKDLTGVSYILVIDPKNASTTHNMVKLIENRYKIITQQLDSALVDKCVERNQRMTLENILNKMNLKFGGVNWAPKFEGEAAELALDKGTYVIGYQTAQPRMSTDRVYTEGEVKIVEPSVLSFTGNYSTNANLFVGNWLYQNAEHEMVNSQTLEDQMFHTLKLLAAKRPTNAKPKNIVVFRDGISEQHYDTFAGVEYQALKNACIRIDPKWKPKFILIVTTKEHDTRIFSRVNGRIENPPPGTMIQIRPGKELLATPQKALKGTVQPVKITLIKNESGVSFDGIMKFVHALSYTHQLTCSPTGLVEPIYQADILAKRGLSSLLTFKEYFPTAVPRQPSLQYDIDGLNKRLTMKDSRLESIRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y983</accession>
    <name>A0A914Y983_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y983"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15836.t1">
        <property type="protein sequence ID" value="PSU_v2.g15836.t1"/>
        <property type="gene ID" value="PSU_v2.g15836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15836.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20603" checksum="85E3FF8BD71A2672" modified="2023-02-22" version="1">MLLIKVYNNVVEIKLQKGDFASSGKSAYLVDKLRKWYFQSQLVNSDTVVVGFRNNNIVNCVKKIKTHDLSLFLKPEHRWHQFSSYSATITILSSVCKFYEENVKENQTLVIELPPNKSHILYHIRDDIIQNMLPKEFKKAFEDDDVHEATTQPVTKQGHILRTEKAWMDDCIEKACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9L3</accession>
    <name>A0A914Y9L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9L3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15970.t1">
        <property type="protein sequence ID" value="PSU_v2.g15970.t1"/>
        <property type="gene ID" value="PSU_v2.g15970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF10">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="671"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="775"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="886"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15970.t1"/>
        </source>
    </evidence>
    <sequence length="1042" mass="113830" checksum="80D334827FCD88B2" modified="2023-02-22" version="1">MQPKMPGNGVGHFMRYFYDAETDTCRSFVFRGGNMVNTNVFQSKTDCEAYCRNDCPVGLMEKGKNDGPIYCDIDDDCGERYGCTKRDINDRGVCCPLPSWICSPDGGRDYNSGERSRLEEYDVGVAPKHVTAVFYPVIRYYYSASENRCKAFMYQGEGGNFNHFETLEHCLQFCSPLTCGNGDRALVLEGKTVSCSSDEPCVAGFQCRHGICCPLKADFCLAGYEVHFEVDDEGITRGRPLNCNHDADCPIPYVCQLTNRIMRSTSRGYCCRRVDFREGRKQNKQPNQSRTTTSIPPSTTAMMSTTPKSTPPTTTHPAPTIPTEASVTMTVTSSSQSMLRCPGGRLPLIDNMGRSKECRINNDIEAMLAGCSGASDYQCAFLNVNSTIGICCQRLKYEQNRCTSGTKPLIDFETTLVRPCSPLKYDSCPGEDSICVFDELFGDYHCCHPLGNPPIITESTTTTPLTTTTTSSTATTTPVAFTPKTTISTRKMHFTPTTSAITIERLRTTTSRFPPENQQGCLLGQDPFQDPLGNQSLECNPNIVGTCPPGFTCHKSHSRTLYICCGVTSVCPRNSAAFINPISQSPIACSLAMGCPGGFFCFKSPYLDSASSGICCSEDPVASLCDRGLSLRNREGKAVRCSPSSTTCPRGYNCLTRFNMSICCPSSENICSQPLHTGLACEESPPQAVYYFDVQSKVCQQFQFSGCSGNDNRFESLTSCQNYCKLLAVCSVGAPLVQLNGELATCTEETSCLAGYSCVFTTEGNFCCPKPEMTCSLPRDAGAQCSPSDSVHSQTALLWHFSITETTCVPFEYRGCGGNFNRFISQQHCSMSCLHALCSNGHPKMKNGRLIRCDPNNACDGGYLCVTPKFGLPNISICCPRTEMICLQPEEKASDCTSISQFRYRFDSVQERCVKFVYSGCAGSANSFGSLEECKKACQTDSNVCPKGSELYVMPDSKLAMTCSPQDPGCPKGYRCSATLDGFLHFCCSEPRCPSGKMPMVATNGSGVICHIGHFGLFDECPDDYSCQQTSSGRFMCCPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCK4</accession>
    <name>A0A914YCK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3553 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCK4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16481.t1">
        <property type="protein sequence ID" value="PSU_v2.g16481.t1"/>
        <property type="gene ID" value="PSU_v2.g16481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16481.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9178" checksum="297666D1099CAB62" modified="2023-02-22" version="1">MPHFGHYEKKKAAQSKELETRPQRSFAIGDIVWYFLTTEKWNPGVITGKVGNVIFTIEDVNSGKEINVHRNNLKHRQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCS9</accession>
    <name>A0A914YCS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15270.t1">
        <property type="protein sequence ID" value="PSU_v2.g15270.t1"/>
        <property type="gene ID" value="PSU_v2.g15270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15270.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13387" checksum="B23A8F4C75789475" modified="2023-02-22" version="1">MSLMGSNYHPQFWNEETIRQLKCSWNINIIRAPITPKSKCCGGWFADPSQPIDNPWEWKSTRDREFGRLKQVIDASVKYGIYVIIDWHIFDFGNNTLEQGREFFANVSQTWGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDH4</accession>
    <name>A0A914YDH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDH4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16799.t1">
        <property type="protein sequence ID" value="PSU_v2.g16799.t1"/>
        <property type="gene ID" value="PSU_v2.g16799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="37"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16799.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41707" checksum="C0C2419AE85F59AD" modified="2023-02-22" version="1">MVRSLSALDAAQSTSANILAPTPASFKINETPFSDSYEIGDELGSGQFAVVYKVTCRKTGAKLAAKFIKKRRYATSRRGVPRNHIEREIEVLRDVGGHENVIQLHDVFETPNDIILVLELVSGGELFDHVCAHEYLNEAEASAFIKQILLGIRHLHNRFVVHLDLKPENIMLLRRGEPRIKLIDFGLSRHIYPGIPVKDMIGTPEFVAPEVVNYEALSPATDMWAVGVVTYILLSGGSPFLGRTRDETFCNITSVNYHFSQTYFANTSQFAKDFISRLFVKDVSARATVDECLQHPWIRGPDIGINDIRVGATINLSKIHGFKVKMRWRRALEIIRFCRAITRQAREEFKASKSMGYAIETKFDPVSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDT5</accession>
    <name>A0A914YDT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SecD export protein N-terminal TM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDT5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17461.t1">
        <property type="protein sequence ID" value="PSU_v2.g17461.t1"/>
        <property type="gene ID" value="PSU_v2.g17461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027398">
        <property type="entry name" value="SecD-TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="SEC TRANSLOCON ACCESSORY COMPLEX SUBUNIT YAJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909:SF1">
        <property type="entry name" value="SEC TRANSLOCON ACCESSORY COMPLEX SUBUNIT YAJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13721">
        <property type="entry name" value="SecD-TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="SecD export protein N-terminal TM" evidence="10">
        <location>
            <begin position="69"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17461.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26566" checksum="B1420CF73D01390B" modified="2023-02-22" version="1">MILRPQQKRTKEHKKLMDSIAKGDEVLTNGGLVGRVTKVAENGYIAIALNDTTEVVIKRDFVAAGIAVLNRYPLWKYVMLIVVIVIGLLYALPNLFGEDPAVQITGARGVAASEQTLIQVQKTLQEEKITAKSVALEEGAILARFDSTDTQLRAREALMGVMGDKYVVALNLAPATPRWLAAIHAEPMKLGLDLRGGVHFLMEVDMDTALGKLQEQNIDSLRSDLREKGIPYTTVRKETTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YER5</accession>
    <name>A0A914YER5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YER5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17246.t1">
        <property type="protein sequence ID" value="PSU_v2.g17246.t1"/>
        <property type="gene ID" value="PSU_v2.g17246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17246.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12023" checksum="44A9A1C7D8579BEB" modified="2023-02-22" version="1">MENKCEAEADEVEFMKLKVTQVLCAGMDIGVIHGMHNTRNLLGQLIFTFGTEFGLRVSSMLSFRGCTFEELTPGILVENIEFIDVERFVAARITINFQKVKTSLSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF01</accession>
    <name>A0A914YF01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17888.t1">
        <property type="protein sequence ID" value="PSU_v2.g17888.t1"/>
        <property type="gene ID" value="PSU_v2.g17888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17888.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9844" checksum="38150A03A126F0A3" modified="2023-02-22" version="1">MENWHPRLALRLHLARVLVLYILNYCTFIYVLYEKYATNAYDLKNEFSNDELDNNNNNNNLDQARSRRQLGGRNPVSYLFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGB7</accession>
    <name>A0A914YGB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1836.t1">
        <property type="protein sequence ID" value="PSU_v2.g1836.t1"/>
        <property type="gene ID" value="PSU_v2.g1836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051853">
        <property type="entry name" value="SH2-Ras-GEF_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247:SF8">
        <property type="entry name" value="RAS-GEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="121"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1836.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32445" checksum="19148AA21ACB7941" modified="2023-02-22" version="1">MDGNNSTTPQVMQFKASQKLLQPNQSLPQNSQEQKSRGIGTNEKSRVAINTMNQAPPSSRQLSSRASGQYAEMADTTIHRSDRPIREVENNNSLSGEGLSIRSNKKINPAVVKALEEIKAWFHGKMDRFKASKLLKKDGDFLVRLGKSMDDLLYKPVLSVKWGQRHYHFLIKEQNSLFWIEKSQFGSIASLIRHNLHTKKPVTQHSGVILSTPILSSKFNPGMARSERDKRMSERDLRNSEGRNGVLEATRSLSYAVFGENAPFILQTLGKVAILCTVITFLWICTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGY5</accession>
    <name>A0A914YGY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGY5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19575.t1">
        <property type="protein sequence ID" value="PSU_v2.g19575.t1"/>
        <property type="gene ID" value="PSU_v2.g19575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19575.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14619" checksum="4F9C95F7841403F0" modified="2023-02-22" version="1">MAALSEAGQTGEAVQAAEALAAKNPSDKKAQLNLANMYMQADQMPKAAAVMDKLRSSGQLTEEREYKQLYSIYANTENKEKDVIAVINEGLQKGILKPDYQVYLALAQSYYYSDQVPQAIDAWQKAAPALQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHA5</accession>
    <name>A0A914YHA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHA5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19700.t1">
        <property type="protein sequence ID" value="PSU_v2.g19700.t1"/>
        <property type="gene ID" value="PSU_v2.g19700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038079997" evidence="1">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19700.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14830" checksum="38D0AEDE4EF6730E" modified="2023-02-22" version="1">MIGKLWLLVVVPTICIGYLPELSPQFDGILQKEAFPFIKTLNKMEAEHYYQFYKDSDEQISFDYVNIGRADWFKKFPEKDVKKEEQELVINDSFLENSVSPVEELVIEYPTASVNTGPRKTTGVIELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHY7</accession>
    <name>A0A914YHY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1693.t1">
        <property type="protein sequence ID" value="PSU_v2.g1693.t1"/>
        <property type="gene ID" value="PSU_v2.g1693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF7">
        <property type="entry name" value="OXYGEN-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="2">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1693.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18064" checksum="CFBE11FDCCF1302D" modified="2023-02-22" version="1">MCTALYHIGSANTSKSKGRWELLLHNGNDVGEGGTTSNLNIFGYGINGMSRSVDIYDSTLANVPSVSLIQVDFGEDIGDLIKMRIEIDGNGEKPDYFLDYVEMKDIDTDERIEINVNSWLKWESKEKGAQAFRELVIFRGSPDTLPYYQGYLEALKKFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YID5</accession>
    <name>A0A914YID5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YID5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18578.t1">
        <property type="protein sequence ID" value="PSU_v2.g18578.t1"/>
        <property type="gene ID" value="PSU_v2.g18578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08871">
        <property type="entry name" value="START_STARD10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041951">
        <property type="entry name" value="STARD10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18578.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="33350" checksum="0700F0CC0FDED803" modified="2023-02-22" version="1">MEVNVVKIFEDEDYRKVKKLCDDHEGWNLVYEKKHNRVWTKPADEGDLLMFKARTVFSDVSADIAYDVLQDPQYRTKWDRYMINTIDIGILNPNNDICYYSREFYSYQFFLCIDIFFFEVGAFPPIRSRDFVMQRSWLDTGSEKYICGHSVCHDDFPPKNSFIRGTIYLTAYFVKALGPNACEITYLTHSDPKGKLPTWLINRVTKVVAPKALKKLHKASINYPSWKNKHNPNWKPWLYPDQLLNAPRIDQAQCRPRNDYAQTIVDESNIKASDVKESDDNEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIF2</accession>
    <name>A0A914YIF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20118.t1">
        <property type="protein sequence ID" value="PSU_v2.g20118.t1"/>
        <property type="gene ID" value="PSU_v2.g20118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742:SF2">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MH2" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20118.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12347" checksum="AD904C4AAE80230A" modified="2023-02-22" version="1">MPPPKNNGAISRTALIERLMKENALDENSSELVPIELEGFSPRRRSWNNFLLFLQDNLAEVDQKLSQIEAQIWGKLIVMERNFRTAKAYLRNSTIIIDGGADEFDGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIN7</accession>
    <name>A0A914YIN7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1937.t1">
        <property type="protein sequence ID" value="PSU_v2.g1937.t1"/>
        <property type="gene ID" value="PSU_v2.g1937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000029">
        <property type="entry name" value="Kinesin-like protein KIF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="624"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="341"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="431"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1937.t1"/>
        </source>
    </evidence>
    <sequence length="658" mass="74691" checksum="4B3FA153FDE9395C" modified="2023-02-22" version="1">MDGSVGSTILHHEEAPPKPFTFDGVYYMDSTAEQIYNDIVYPLVEKVIEGYNGTVFAYGQTGSGKTFSMQGDEKVPAQRGVIPRTFEHIFESIATTEHTKFLVHVSYLEIYNEEVRDLLGDDRQKKLEIKEHSDRGVYVAGLSMHVCHNTKDCDTLMSLGFNNRHVGATLMNKDSSRSHSIFTIYVEALSETGSIRMGKLNLVDLAGSERQAKTGATGERFKEATKINLSLSALGNVISALVDGKSSHIPYRDSKLTRLLQDSLGGNTKTVMIACISPSDNNYDETISTLRYANRAKNIKNKPKINEDPKDALLRQYKEEIERLKNMVHTGGPTATGNAIEHDVEAEKTKLREEFEAAMRELRSQYENEQKSKEKLASDLQNLKSQYEKANKEIDQAGADEPSDPKEIRKRIDALRQQLVGGEEAGNEVLKAKRSKKIKEAEKRMQRLNNTLQAASRDDPLMHVYSSTQEKLEAITRLYKADVQKIRTLESEIQDIQAEFEMDRLDYLETIRKQDKQIKLLSQILDKIHPVLKKDSNYGSLDKIKREAIWNDDQAKWILPEFNMGRVGLPNAHSILPGVRAEIPSYGLEPDEDIRLKKRLEKTMEDNISENYFKPVDKTNLLNRYKGDRTKSGNDLYSSDDSRSLSAQRRPHRLEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK08</accession>
    <name>A0A914YK08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19863.t1">
        <property type="protein sequence ID" value="PSU_v2.g19863.t1"/>
        <property type="gene ID" value="PSU_v2.g19863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037895544" evidence="2">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19863.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14344" checksum="89DAFC04BEDC7550" modified="2023-02-22" version="1">MKLLVVLALIGFSAALVIPKKLKDDPNCGLRSALKAFQPRPIHKEATFICEMCLDLVQIGEMYADCDEAYVDKKMDEKCDSYFHTGFLDKVCRDMIDDLYKELEADTDKDPSKVCTKVTKHDCHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK09</accession>
    <name>A0A914YK09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK09"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19663.t1">
        <property type="protein sequence ID" value="PSU_v2.g19663.t1"/>
        <property type="gene ID" value="PSU_v2.g19663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF6">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19663.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16949" checksum="EBA017A82FC5E4FF" modified="2023-02-22" version="1">MSDIRCGRLQLEDLLISPLQRITRLPILLKEILKYTEGFDEKSRLERVLETMNENLRSIDDSVQWLHNFERLQQLQNLVIWPSVLEMEPKTFIPDFLKGALSKQFCENLLAHPRRKLVHEGPLEFVENGRITDCYAFLFNDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKG6</accession>
    <name>A0A914YKG6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YKG6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19835.t1">
        <property type="protein sequence ID" value="PSU_v2.g19835.t1"/>
        <property type="gene ID" value="PSU_v2.g19835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19835.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22798" checksum="2FFF3D4716CBD3AC" modified="2023-02-22" version="1">MSKYSDFIALVDEDYFNIHDIMATRANIACTFSQGTPSEFFRLIGQHAPETISEKGYKTETPSWIICTLKDDAINYLPQLPKAFSENTRNSLLAGPEGKNLENLSLHFYLFGIRLALLLKGKNGSQIAYALMRIFEQRAGWILKLAVDPVFKPLMLDLTEKRIFFKAQTSEIRTIDWFHRNYKEIQTVSRKRSHAEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKU1</accession>
    <name>A0A914YKU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKU1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19497.t1">
        <property type="protein sequence ID" value="PSU_v2.g19497.t1"/>
        <property type="gene ID" value="PSU_v2.g19497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="3">
        <location>
            <begin position="30"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19497.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="37715" checksum="75E7D7FA92DD18D7" modified="2023-02-22" version="1">MVKRIFIENSVDSKILGETIIFPTSKKVAKNRFFKAALSESLAAYDPSNVEIHGLPNEMHANLYEKWAAGGFGVLVTGNVITDEMHLESPGNTIITKELDLPKRREIWKNIASKAKQHGALIIAQLGNAGRQTSIIVNAKPFSASNVQLKRDAAYREYGVPIPLTTEQVKTEIIDKMVYASKVLYECGFDGVELHGAHGYMIAQFLSRTTNKRTDKYEIPANTGFIVGIKLNSVEFQREGLTGEESAIIAAEIDKAGLYFIEISGGTYEVMAFKHKRESTLAREAFFLEYAEKVKAVVKNSKIYVIGGFRTVPGMVKAIENNETDGIGIGRPITQDFGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKW1</accession>
    <name>A0A914YKW1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YKW1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19983.t1">
        <property type="protein sequence ID" value="PSU_v2.g19983.t1"/>
        <property type="gene ID" value="PSU_v2.g19983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
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    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TIM44"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="12">
        <location>
            <begin position="284"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="60"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022927"/>
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            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023010"/>
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            <dbReference type="ARBA" id="ARBA00023128"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="PIRNR" id="PIRNR037871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
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            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19983.t1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50828" checksum="BBAA7F0B7C1E7DA5" modified="2023-02-22" version="1">MKVIRNVIQISRLGNVTSQRPLSNQLVLLNQAQLQQISLRTFSAENQKPKNFFTTFVDTLKDELQKNKDLQEHKKILNERLKELNEADALKEARQKFNKVEQETAQSTEVIRHRVKEFKDHFEKVVTDLQKTEAGKKLSVAGQEALKQAKVAAEFLEKTAKDIGDTQVYQQVSSTAKSVQREIDNIADVRMYSRPQELKMRSADFSTSAFANRTVEANDQATDIELHKESRWYQGWKSFSENNSYYNKVLDWKIRYDESENLAVRLVRGVTERVGSVFSSSNEVSEVLTEIAKIDPKFDKTEWLRFCEKEVIPNILEAFIRGDLKVLEDWCHERAFVMLSTVIKEYQKSLFTTSASRIIDISKVEMVSGKMMDQGPVIVITFQVFMINVVKNADGKVIQGDPNKPVRVHHVWVMCRDMEEYNPATAWKLLELHMQEGALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLB0</accession>
    <name>A0A914YLB0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
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        <property type="protein sequence ID" value="PSU_v2.g19682.t1"/>
        <property type="gene ID" value="PSU_v2.g19682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15557">
        <property type="entry name" value="PHD_CBP_p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031162">
        <property type="entry name" value="CBP_P300_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003101">
        <property type="entry name" value="KIX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056484">
        <property type="entry name" value="PHD_P300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010303">
        <property type="entry name" value="RING_CBP-p300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038547">
        <property type="entry name" value="RING_CBP-p300_sf"/>
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        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02172">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23570">
        <property type="entry name" value="PHD_P300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06001">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47040">
        <property type="entry name" value="Kix domain of CBP (creb binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51727">
        <property type="entry name" value="CBP_P300_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50952">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="21">
        <location>
            <begin position="76"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="KIX" evidence="22">
        <location>
            <begin position="257"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="20">
        <location>
            <begin position="484"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="CBP/p300-type HAT" evidence="23">
        <location>
            <begin position="714"/>
            <end position="1098"/>
        </location>
    </feature>
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        <location>
            <begin position="1154"/>
            <end position="1235"/>
        </location>
    </feature>
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            <begin position="76"/>
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        </location>
    </feature>
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            <begin position="1154"/>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="193"/>
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        </location>
    </feature>
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            <begin position="339"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="410"/>
            <end position="432"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="980"/>
            <end position="1012"/>
        </location>
    </feature>
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        <location>
            <begin position="1261"/>
            <end position="1323"/>
        </location>
    </feature>
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        <location>
            <begin position="1336"/>
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        </location>
    </feature>
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            <begin position="1434"/>
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        </location>
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            <begin position="11"/>
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        </location>
    </feature>
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        <location>
            <begin position="216"/>
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        </location>
    </feature>
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        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
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            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
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            <begin position="987"/>
            <end position="1005"/>
        </location>
    </feature>
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        <location>
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            <end position="1275"/>
        </location>
    </feature>
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        <location>
            <begin position="1294"/>
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        </location>
    </feature>
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        <location>
            <begin position="1434"/>
            <end position="1493"/>
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        <location>
            <begin position="1515"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19682.t1"/>
        </source>
    </evidence>
    <sequence length="1580" mass="180839" checksum="E65999450475355A" modified="2023-02-22" version="1">MQVNGSMQRMPPQNLQQSQQPQQQPPQPQHQIPNQNIVSQPPPAAPLNDQPGSTPLSGTGAMPPPSSGTPNYHTQDPEKRRLIQQQLVLLLHAHKCQQRERGDATSKQNVCTLPHCSTMKSVLDHMTSCQNGRACNYPHCASSRQIIAHWKNCVKDDCPVCKPLKCFNKGTNNNTSFGSPQSNTSTTSFLNETEAFPDPFRSPNPPNRPATGGMMPSSSQINNSQQPRNPAITATLGLNSNMTSESIGSLPPPDPPSQNKPWHQSINKDLRNHLVGKLVKAIFPSPDPAAMQDQRIKDLISYARKVEKEMFEIASDREEYYHLLAEKIYKIQKELQEKKNRRLEQSQRGDGDSRLPPQQIPSAASIKADIQQDVSRNIPDASLPNSIPDMNSEMEVDQELKDIKPKIEPMEEVEEQAPSSATSEVPPPSADIKDVKDFKDVKDFKDVKDINPVKKESEEVPKETIEFDIEELRRMLIPVWKAVDSAEEAGPFRLPVDVEILQIPDYYDVIKNPMDLLTIRKHLDSNHYTNPKEFNADMWQMFDNAWLYNRKNSKVYKLCTKLSEIFVENMNPVMENLGFCCSNRFNFTPLAIICFGQSGCIIARDQTYYLYEASSSKYGVNVSERYIYCQKCFDALPACGLNLNEAQNEPPNYAPKEKFVQMKNDNIDTEPFETCKVCNRDWHRICANYYKKVFPEFICDTCRKAKGLPKPENKYTAKRLPHCKLSKHIETRVNNYINKKVGSKEKDKYEVVIRVLCSTEKEEEVKPLMKSKYSPQGFPEKFPYRTKAVFAFEVVDGVEICFFGLHVQEYGSECKSPNSRRVYIAYLDSVHFFQPRELRTDVYHEILLAYLDYVKKLGYTMAHIWACPPSEGDDYIFHCHPPEQKIPKPKRLQDWYKKMLDKGVSENTVLEYKDIHKQAKDDGLSSPSELPYFEGDFWPNIIEDCIRDIEKEEADRKREEDIADDEDDIFTLDDAKAKKPVFGASKPNKKSKSLKKAPSKTKKGKGNGSGNEVTDKLIAALEKHKEVFFTIRLVSTQTELSNSTKPISDPDPLMPSDLMDGRDLFLSKAREEHWEFSSLRRARYSTLCFCHALHTQESKDMNYTCNSCQSTANWHCSTCDDFDLCNKCHATNTHEHKLEKMNTLIEVDKSADSTNTRNESIQRCIQSLVHACQCRDANCRRVTCHKMKKVVQHTKLCKKRQHTNCPVCKQLIALCCYHAKHCSQTNCAVPFCSNIRLKLQEQKRLQNRRADMLMRRRMEMLNSGSSSGPTQSHSSQPPPAPAPSKPQVNGSQSPTTNTTPNPRNPSAGKKPASSPSYNSTVPQQIQQPAVQNAYNQNPQQMSGMGSQQGQSQQHPMQQQQQMGYQQQQQQHSQQIPQQHANSQQAMRSQMMQQQPQIMQQRQMNQQQQHNYMNSNQQQMPGQQQQYMRQHEYMMPNQQQQPPTQQQQQQISQQQYAAQMQQKMQMQQQHGKRPQMMQQQQQPQQPGSQQGMVQHNARGDQIMPQGHQVHPGHPQIQPNTTTCGIRPTTSDPIIQRIYDRLKVAKNQEERQVVFKDLKRTPHLFAAFLKVYSAPNEFTNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLY7</accession>
    <name>A0A914YLY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20586.t1">
        <property type="protein sequence ID" value="PSU_v2.g20586.t1"/>
        <property type="gene ID" value="PSU_v2.g20586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20586.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15613" checksum="A367C163640C8151" modified="2023-02-22" version="1">MMRRYGRNTSDISPEPIRGLNVSDLNITNNNNFNDRIYIGPIQLSFSTSSSESHQGGEEEENISIISSDSSDNNDTTDDDEEENGIDLDAIMRHIDDCGRHIKRNLTDIVRVELQNLLDSLQPRKSLVPYPLSSDEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM86</accession>
    <name>A0A914YM86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20036.t1">
        <property type="protein sequence ID" value="PSU_v2.g20036.t1"/>
        <property type="gene ID" value="PSU_v2.g20036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20036.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37922" checksum="2CDA235EA0F952B4" modified="2023-02-22" version="1">MRIFQGIAASALFAASGAIINSWATIEESGLFLAFLSCHHQLAEIFLMPVAGFFCESSVGWQGIYYLQGSLTFAFFIIFFIFYRNSPQNHRYVGKKELSLLTDGKDSSEHKTSKQSNIPYSKIIRDKSVIGLWIGAIGSFTGFQLFLQYGPTFLNKVLKINVKKTGIFGAIPFFGALIVKAFSGPFSDRLTFISQKRRCQIFGSISQFSMALCIAALGWMPIKSEIFAQIAFTAAIMFSSLNVVGLIKSAQLQSRQYAHIVMNVIAFINSGIILLLPLFISTFAPNNTYTEWAIIFYSIAILVTVTTTIFDITCEADPRPWTYKKVDDCPPNESIKLRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YME2</accession>
    <name>A0A914YME2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YME2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20094.t1">
        <property type="protein sequence ID" value="PSU_v2.g20094.t1"/>
        <property type="gene ID" value="PSU_v2.g20094"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g20836.t1">
        <property type="protein sequence ID" value="PSU_v2.g20836.t1"/>
        <property type="gene ID" value="PSU_v2.g20836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20094.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20836.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14346" checksum="5FF2B15093B392E2" modified="2023-02-22" version="1">MADRISQLQDLVNDLANHMCNAIGHLQGSAPPSDFGRASDELVKEENADLFAANIARTSKDIEIIIQTLPNVPVAPEEFQPIFLENEAERECLVNNIKEQMEETTNMMADLRDMMEDIAKVQSVGFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMR7</accession>
    <name>A0A914YMR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMR7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2191.t1">
        <property type="protein sequence ID" value="PSU_v2.g2191.t1"/>
        <property type="gene ID" value="PSU_v2.g2191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052641">
        <property type="entry name" value="AKAP7_isoform_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934:SF2">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2191.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24641" checksum="516866DB5F7C3CD4" modified="2023-02-22" version="1">MILLIPIFAKKHSYNLTPKLPPPNVFVTVHIEDDTVIKNVNKIQQKLLSVDPRFNSTLQKLTSLHTTFDIFYIDRDHLQKAKTALEFAATMSATHFGPLNITFQRIETFDNITFVSRTNFGSKIVLTQYQKKINEIFKSFGFMPQSKFKYKPHMTLAQLGHDHTELMHKWDFLLKNITKFGNFTPKKLQICAISMARKDLYYPVLAEAYLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN49</accession>
    <name>A0A914YN49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YN49"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20376.t1">
        <property type="protein sequence ID" value="PSU_v2.g20376.t1"/>
        <property type="gene ID" value="PSU_v2.g20376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20376.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16442" checksum="62255250169EE50A" modified="2023-02-22" version="1">MRFLFNFLQNLFEFPRQQENEKTKTPEVAHFKASQKLLDPNHLTPGPMQQSCVLPPVTAIKDIDGIDKKLDAPTTPLKPLKKRSSVSLVADLSKCPKINVDDYINKLMTSVDKDGNITDYLTDTAVIEQICVLAMLVLFFFLLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNC9</accession>
    <name>A0A914YNC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNC9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20906.t1">
        <property type="protein sequence ID" value="PSU_v2.g20906.t1"/>
        <property type="gene ID" value="PSU_v2.g20906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20906.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14036" checksum="1954E9D74B9617D2" modified="2023-02-22" version="1">MQPLVKLSLREQLHQELLSFNRTNLNHVETRKGVMPVVDPVNKKSFEELYVIIPLGTMVDESCQTDLEPAFTSFSDKDQNTATFISEPDSGIDLDEDVEWQLFEEHVSLIRVEETEYYLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNZ3</accession>
    <name>A0A914YNZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21342.t1">
        <property type="protein sequence ID" value="PSU_v2.g21342.t1"/>
        <property type="gene ID" value="PSU_v2.g21342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21342.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="25109" checksum="D753BE7FB11205CB" modified="2023-02-22" version="1">MVTSFSDEDAALAITFLPPLADLAARALHDVEHAGRHARFGVDLGQPDGGQRGHFGRLEHHRVAGGQGRGRLPHGDLDRVVPGADAGDHAQRLAAGVEEARFAQRQLDAFDGGGQAGVVLDHVGTGDDVHGGGFGQCLAGVQGFQMRQFVVALAQDLDGAAQDARTFHGGHRSPHLLAFGRALHGAFDVRLAGDLHFSDHFTGGRVDGFEGLAAGGIDALAVDVELLDGQGGHGAYSLEGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP76</accession>
    <name>A0A914YP76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YP76"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2645.t1">
        <property type="protein sequence ID" value="PSU_v2.g2645.t1"/>
        <property type="gene ID" value="PSU_v2.g2645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2645.t1"/>
        </source>
    </evidence>
    <sequence length="812" mass="91253" checksum="2778EFBC4F372D30" modified="2023-02-22" version="1">MFLGSILHTDLVGRPIKDFIHPTDYDELMRISTEEAAASEEHRSTADDATIHKYGHRMIMRMKTVISPRGRNLNLKSALFKALVCRCRSMQFETGKIMLVHASTTPAGQGNSIMMSNTSAKGSETTSGSFMTRHTCDMRFSYVSENFNYLLRHESRSLMGTSFYDLIHPSDLDTISDSMKELFRKGHCRTPYYRLIGANNSVAWVQTEATTVNHTTRGQRGQYILCVHSLVGMQSDLDSWTTAGTVCSDVLAAAQPACQFVKAEIDDVAEYLGRQPQFIDCYDFTPLIDSDAGININEYRPMRDLSNPQQQQSTVAAGSTTTTTTMNNNNNNNPRKRKMLLPCVLESTAFDSIRNFEDDKEEGGGRTEKNNLEKSVAEIFCDKIWDQIKSEIIADEECYQARTSNAQCCGSDRNHSPPPLEEVNLLACYSDKIQQELQAYQPAPFKRCSSTSTIFRKHIFQVFTNIFFLKANLFFAYAFLFFLHVCCRPFYRIPLVCQQGVGRLKVDDQTDWYEWEEAAEQLPPRPQRRNTIASSQEPSGATTTTAATELSKSTPFCSLTAGFADFGVQSSPDDEGIFSDNCPLRRPSSDGRCHNSSNSATPPFIQSQNSYSNPVSTIPTHDIYAMPNAGQFNPSESRCDANSTLHSILLAPGSKRNAFGQSPTAVNVSHLNPTAEAPQQISREFFEEFRQENPHLFPTEQDTCYDVDMCNPYQQCSSDPFESLAPFVPEEDILQLNSEPFPLDINFPELDLSGYTFEPSFGKHIQPPNQFATKIQSCNKASNNYMLDSQDSYNHPIPTKRARIDDPFPLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRW8</accession>
    <name>A0A914YRW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRW8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2918.t1">
        <property type="protein sequence ID" value="PSU_v2.g2918.t1"/>
        <property type="gene ID" value="PSU_v2.g2918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF11">
        <property type="entry name" value="SOLUTE CARRIER FAMILY RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2918.t1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52289" checksum="C3D43E3E8A3F7115" modified="2023-02-22" version="1">MEIQHESRWKIALRQISQWKIQVEPIIFVLSLCNAARSVVSPHLMEEKMKRTYFPSTPLSPSELKKFYNKKIVLWDQNYEYVNLPIACLAGIVYGSYSDQRGRKLPLLIGLFSVIIDNIFYMLIWSEKTDISLQWLFLGASIVGLMGDFMLLMSCVNAYLADQFGNKRTLSIRMILVSTIFSLGSFCGSQTVDHLVDVIGGIGTMFVVQGALIITFILSILILTNPLPMKQQNLNDDADTEAVIHTEAIEAEEIQQPSQSFYKAVIEKFQFLFNSIKIFYIPREGHRRLFLYACFAANFLDQLVFGEEKGLIGKYTLLDPFNWSTHEYARYKEIRPILRDTFIIVLAIASMSLSTLVIGLAKSSALIYASLAPGSLHGLLNPLTYTFITCLVEPSEIGQTFAISTIAGKLAGIVQTAVLDTLYRITVEWYQGFVWLVMFLISAIAAFLYLIIHIIAKKEDIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSS6</accession>
    <name>A0A914YSS6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914YSS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3064.t1">
        <property type="protein sequence ID" value="PSU_v2.g3064.t1"/>
        <property type="gene ID" value="PSU_v2.g3064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3064.t1"/>
        </source>
    </evidence>
    <sequence length="390" mass="42413" checksum="5AAE40D98743617A" modified="2023-02-22" version="1">MPSTAGQIIKCKAAIAWEPNKPLSIEEIEVHPPKAHEVRIKITHTAVCHTDAYTLSGKDPEGLFPSILGHEGAGIVESVGEGVINVAPGDHVIPAYVPQCKECDFCKNPKTNLCQKIRISQGNGTLPDGTVRFFKDGKAISHFMGCSTFSQYTVVADISVCKVDPNAPLKSVCLLGCGISTGYGAVVNTCKVPKDSTVAVWGLGAVGLSVIMGAKIVGAKKIVGIDTNEKKFEIAKQFGATECVNPKEAGDKPFQAYLVEKFNGGFDYTFECIGNVNTMRQALEAAHKGWGESCIIGVAGAGQEISTRPFQLVTGRTWKGTAFGGWKSMDSIPKLVEEYMTKKIKVDEFITHNFNKIEDLNEAFDVLHSGERVKQLFLRMFIFFERLYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YST7</accession>
    <name>A0A914YST7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YST7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3073.t1">
        <property type="protein sequence ID" value="PSU_v2.g3073.t1"/>
        <property type="gene ID" value="PSU_v2.g3073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664:SF4">
        <property type="entry name" value="DUF4440 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664">
        <property type="entry name" value="PROTEIN CBG16427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3073.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14192" checksum="0C7954101A698288" modified="2023-02-22" version="1">MAISKKDAENLITKIQDDFYKKWSAGDAKGLAAFYHPDAVLIERGKSVAYGLEEIEKKYVEALKTPMGFKLNFELTTPAADGEYIIHRGTFVFDAQPDKPALYAQIYKRSKDGQYLIIHDIFENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT19</accession>
    <name>A0A914YT19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Catalase core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g2807.t1">
        <property type="protein sequence ID" value="PSU_v2.g2807.t1"/>
        <property type="gene ID" value="PSU_v2.g2807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08153">
        <property type="entry name" value="srpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024168">
        <property type="entry name" value="Catalase_SrpA-type_pred"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="8">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2807.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="36419" checksum="74FEBE921866E129" modified="2023-02-22" version="1">MGRLSIGGGDPYGADNTARVRSLAVQMVSDDGQEWRMAMNSFPFFAVPNAEAFYEQTRASIPDPATGKPDPQKMAAVLAKYPSAQAFQQWAKTAPWTSSWADTTFNSVNSFWFTNAQGQKRAVRWRWQPQAPVVEMDAETRKQASVDFLSQELQQRLASGPVRWNLVVTTAEPGDAIDDPSVPWPESRDQVVAGVLSLDRMQSQDRHRQRPLQPARXGAALVHGADDHRHAVHRRDHGRLAAPAADADRPAPSAGHRHRRTGAVAPVQPAAPSPATAAGGSSGVAGDGGQGLALDAVRADVGDAADRLGDAVGRRLPDRAVGRPAPAADRAAHPGAVCRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT76</accession>
    <name>A0A914YT76_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFU1 iron-sulfur cluster scaffold homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YT76"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2867.t1">
        <property type="protein sequence ID" value="PSU_v2.g2867.t1"/>
        <property type="gene ID" value="PSU_v2.g2867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="4">
        <location>
            <begin position="61"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2867.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30583" checksum="A107F95CD7D95B82" modified="2023-02-22" version="1">MMRNILLTRGIPCCSKLLHSTFQKNVSHTSNLQVRKFSNTFISSKLLPFSTQFIQSRNLFIRVEETPNPLTLKFLPGEKILENSSRTYEFSSASGAKQSPLAIQLFRVEGVKNVFFGEDFISITKQSEDEDWGVMKPNIFATIMDYIQSGKPVITDLETLESQPTDTTIMPEDDDVVAMIKELLESRIKPMVQEDGGDVIFKGYEDGVVKLKLQGACTGCPSSSITLKSGIKNMMQFYVPEIQDVVEIKDEADQLIEDELKKFETKLGKSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTF2</accession>
    <name>A0A914YTF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2950.t1">
        <property type="protein sequence ID" value="PSU_v2.g2950.t1"/>
        <property type="gene ID" value="PSU_v2.g2950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2950.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18054" checksum="C2DBAD66844D8D76" modified="2023-02-22" version="1">MIESAPISLHHHCIKPANSNLLADMKNNYPEIGHDVMGGEVDLLCSPVSKMFASINEMALEYEQKLTAVGCDFDEYCRIVSMSDGARRFLQDKLTAATLVYFAFGAEYRQYLTDDVSILSKLSIPLLMIIAFQSRFDTSYRKKACSLLRYVLIFEYNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTM2</accession>
    <name>A0A914YTM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3016.t1">
        <property type="protein sequence ID" value="PSU_v2.g3016.t1"/>
        <property type="gene ID" value="PSU_v2.g3016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3016.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14212" checksum="B397E10B202DBCDA" modified="2023-02-22" version="1">MIFDIQNLTFGIFKKIVECTEILRLSNTKIYFSDDTIAHFEDILPCIPNAYFIYIFKCCYVSPRTEKMLLLIKRNPKFSTFEINYIEGDVDTDKFWEFVVKNIQPRARVEICWGYPEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU70</accession>
    <name>A0A914YU70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4196.t1">
        <property type="protein sequence ID" value="PSU_v2.g4196.t1"/>
        <property type="gene ID" value="PSU_v2.g4196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4196.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="6910" checksum="179AADCC313B772B" modified="2023-02-22" version="1">MPGPAGPAGPAGTSGPQGPPGPNGNPGSDGAPGPAGDAGSDGSPGKPGENGDHGADGEQGNGGDCSHCPVPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUM1</accession>
    <name>A0A914YUM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUM1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2118.t1">
        <property type="protein sequence ID" value="PSU_v2.g2118.t1"/>
        <property type="gene ID" value="PSU_v2.g2118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2118.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43328" checksum="E0E4BBD257BC67DD" modified="2023-02-22" version="1">MILLLFLEKTDPIKASTSDGNLSDNSCTIFIDAEKEVIVVNTAEFGAMTVLFAQLLGQKENSLFFKIDINRKLKLQFDDINTAEKVGKMIEKVKETSKSLKAEESTLTLALEKLEDDPRSIEDIKDLFKYYSKVFTIFKEEHQNRIYELYQKYDFHEKIVAATENHTVDSRDDEVRTISNGTPNSRKRKAVNYDQVPAKKVKMDDSEIIYYPDFEFQCDSEGVPKKELIVFASKTKCYKFSLDSNGYVCSGCTGDEAVQAKYYVNEYGETFIKTKGKHDCRPVLHKSEKLAAAKMTLFEFFFERQDRRSSSSKKLRVFTPSKNACYEFLHLEDSETELWYCVKCKIQGKYVYSHLEKSPDGEQLVTLLDEDHKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVC8</accession>
    <name>A0A914YVC8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">methylenetetrahydrofolate reductase (NADH)</fullName>
            <ecNumber evidence="11">1.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.54" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914YVC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4547.t1">
        <property type="protein sequence ID" value="PSU_v2.g4547.t1"/>
        <property type="gene ID" value="PSU_v2.g4547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006950">
        <property type="entry name" value="PRK09432.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4547.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29004" checksum="150D43401B5ACD73" modified="2023-02-22" version="1">MEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYASDLVTLLKEVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGVRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWV5</accession>
    <name>A0A914YWV5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chloride channel CLIC-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel MCLC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWV5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4586.t1">
        <property type="protein sequence ID" value="PSU_v2.g4586.t1"/>
        <property type="gene ID" value="PSU_v2.g4586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009231">
        <property type="entry name" value="Chloride_chnl_CLIC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093:SF1">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038128045" description="Chloride channel CLIC-like protein 1" evidence="10">
        <location>
            <begin position="17"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4586.t1"/>
        </source>
    </evidence>
    <sequence length="428" mass="49155" checksum="16BC26E78A391945" modified="2023-02-22" version="1">MLILIFLGLFLVGIHGINEIPQHSNAEELDVPGDPFSDENLPKLNFDDKKCNLEEYTKEYQKVIKEWEERYKKLVKLNHADVDVFFKQFIEEFAYRLNFKLDDTLNGINRTAIVAFLPKDIALLKDYISKTDPTKSLRTQAKDKLIKSVYESFDASPLAKSAILPNGILIGGFLIIVAFAVFFHRFLAIAPNEYIISTIIIIFLTIFMISCWSHYNMRLEEAVARYKEKQSKFTGKECEPLTSWQWFSGTILGYVTIKRDTPCYEYHLNMQQNVKHQIKLTKIIGEVFTEWISSGLFVIGEPIRAFCDSLYKDAPLQMIPLLTAIFILVFGFIFIFLFLGTLRLFNVKIHSPFIGISFGSKDGNTVVADQQKSALQMKEMIAAITAMNQRLEDSLRQNNAIKNQGMMPREIEGVRRRGSRDPQVAKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWZ3</accession>
    <name>A0A914YWZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4626.t1">
        <property type="protein sequence ID" value="PSU_v2.g4626.t1"/>
        <property type="gene ID" value="PSU_v2.g4626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF8">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4626.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40826" checksum="37DB121561F8B9D9" modified="2023-02-22" version="1">MPECQGFASTGVSLSEIVNNPLYDIYRFWIRRIMTIFIPFFVLASCNVAIVYNLRGNQKDKMVKHLILHMTSGHSKDLTRLKSRVRTATQILIIVVTCYLFANIIDVIIAFLEYMAPEALQEYDAFYTIATDVSSLLSTLSSALRLPIYIANDKLIRHEIFCQVKRIYYRVLCCKTQNAKQRAFDSEKRRLVYEQVEQASTTPPAINSNPGNRSRISVDSSKIHNGIGGLIFARASVTSSMHDSTVTNFDITKCAAIYAHAVSRQGTRLSSDSSLDDSLAQCVVCENPQGPNGSFSYPRKVSLIDPRGPIRKKISAPPKLSFDIPIIEANDSDVESKSTSNNTPVPLKRNYNDRGDMLYWSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYT5</accession>
    <name>A0A914YYT5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L12</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYT5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3197.t1">
        <property type="protein sequence ID" value="PSU_v2.g3197.t1"/>
        <property type="gene ID" value="PSU_v2.g3197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3197.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="17869" checksum="AD5C50E9E3402EEA" modified="2023-02-22" version="1">MPPKFDPNEIKIVYLRCVGGEVGATSALAPKVGPLGLSPKKVGDDIAKATQDWKGLKVTCKLTIQNRIAKIDVVPSAASLLIKELKEPPRDRKKVKNVKHSGDLTFAQVLNVARQMRPRSMAKKLEGTVKEILGTAQSVGCTVDGQHPHDVVDAIRNGTMEVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ06</accession>
    <name>A0A914YZ06_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZ06"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5181.t1">
        <property type="protein sequence ID" value="PSU_v2.g5181.t1"/>
        <property type="gene ID" value="PSU_v2.g5181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF12">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5181.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28851" checksum="3758566EC56924D9" modified="2023-02-22" version="1">MLCVIHTAAVSHDTLAKTVYDIWGKKCDDTLFFTDSPIDWEVPHIYFPRFTTRKHSWEKIRNVMRFVYHTTLGKYDWYLRADDDAFVFVDNAKKFLRRYDPAKNFLFGFRWGFFEPKGFADGSTYVMSWKALESFVNITYDDNLCPEFHRAEEDQELSRCLAKINVTPSDARDYQGRDRFHQFHPEELNDFGRTIFMNRHSYYQFLGYPDHISPTTIGLHHLSPYEMRFMDFLVHKAKISDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ88</accession>
    <name>A0A914YZ88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Receptor ligand binding region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZ88"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5414.t1">
        <property type="protein sequence ID" value="PSU_v2.g5414.t1"/>
        <property type="gene ID" value="PSU_v2.g5414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="82"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5414.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21192" checksum="DD35658A692456EF" modified="2023-02-22" version="1">MESTAAGYAYELIENDQVDLLVAPPCIDAAIVAGHVATYYNVPVTLWGVTFATTLSDDMMYPTIMSVVPNYRDMATVTCEDVINNRSDCIVSFKDIVDSWAPEDINYTLTQMRSKSRIVVLCFDDQDQLRSFALALYDEGMYTDDYVFIIPDSDMSKSVGLDVAPFWIDQYTPSDGRDADAAKVGKQNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZN6</accession>
    <name>A0A914YZN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZN6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5565.t1">
        <property type="protein sequence ID" value="PSU_v2.g5565.t1"/>
        <property type="gene ID" value="PSU_v2.g5565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052641">
        <property type="entry name" value="AKAP7_isoform_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934:SF2">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037456311" evidence="1">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5565.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23633" checksum="EA739C5F5F128C93" modified="2023-02-22" version="1">MMKIILIFVFISIAPKISLAYSHFISYHIDSSDVRNRVAEIQAGLLQKDPLFEKYFEKLTSLHVSVDYLELNETSIEIAKTALSEAGKKLSTSSVSLRGFGSLVGFLYVNAFSDDDQPLALIKNKESVKNTFATFGIQTSWWWPYVAHMTLANVNGPDQPRLEFKWFTLLFDARKMGSFEIKSIRLCAWDIPEGDDDYPVLAEAFFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1T8</accession>
    <name>A0A914Z1T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1T8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6665.t1">
        <property type="protein sequence ID" value="PSU_v2.g6665.t1"/>
        <property type="gene ID" value="PSU_v2.g6665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF0">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6665.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28135" checksum="E20B95DE6212DF5D" modified="2023-02-22" version="1">MKEERREYKDSNGNVFEGFLAYPNGADNSDKKLPVVLVHHAFAGITEHEEEKTRELARLGYVAFATDCFGKGIKGNTKEECFALLKPMVGDRRGILKDRLFAALDFVKNLSYVDSTKIGSIGFCFGGLCALDLSRYNCGISAAVSFHGSLDPLPSLENPPTEETEPIKSSIMICHGDADTHIPVEKAVAIMEELRNRQTDFQFISYANAKHAFTEIKFDNCGIPGIGYDEKACRRSWNQTLYHLNEILRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2J2</accession>
    <name>A0A914Z2J2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2J2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4472.t1">
        <property type="protein sequence ID" value="PSU_v2.g4472.t1"/>
        <property type="gene ID" value="PSU_v2.g4472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4472.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35064" checksum="7482CF5D3DD50833" modified="2023-02-22" version="1">MGDEFESNNFENIEAGSNESLLDMLHGIASKHPYSPALKSSKSHLTSEVDVSFKDLEPPLSGRSYTAACKTSPTQISDDRCSRLSTVSTSSYFAKNPDMTMFYSPQIPIEHKPEKVVEEINKQFEPMKMKMLSESVKLQPQPVQQIQKVTFAKPLINSFSTSVPASPSQSYRNIAAENSATFASTVERQSERVVEEQPVKALNVSIDGQPKPVQQVQKVTFAKNLVHVSSPSREAISSHTVRQQQPAPPANASVQRQPLRALSLGDQSSVPLVYAPTRHPLPKPAPQIGKRSKMLEFWRQKETENGGLPISYSNSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2P8</accession>
    <name>A0A914Z2P8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2P8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4531.t1">
        <property type="protein sequence ID" value="PSU_v2.g4531.t1"/>
        <property type="gene ID" value="PSU_v2.g4531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4531.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17226" checksum="1DAB1147E4839190" modified="2023-02-22" version="1">MSSLKELFGIDKLMKFKEIVKNAGGIRGALKQSYVQSSLRQGTLVGEDKLGNKYFEDNSYFMPRNRWVQYNEKVWLDFDASQVPPEWHRWLHHITDKPPTVEPSVEHKWIMKHAENVSLYSGEKYVPYSTTRPKVIGWQPGEKKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2X8</accession>
    <name>A0A914Z2X8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z2X8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6244.t1">
        <property type="protein sequence ID" value="PSU_v2.g6244.t1"/>
        <property type="gene ID" value="PSU_v2.g6244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000468">
        <property type="entry name" value="Short-chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037873513" description="3-dehydrosphinganine reductase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6244.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="29923" checksum="4D774090C85272FF" modified="2023-02-22" version="1">MSLSPVISIVLCFSLFYKIFTGGSKGIGKEIAFEVIRRGASTVSIAARSIEALESAANEIKTLCQPEQTVRYYQMDATGGFEKVKSVMNVASEESGSINVLINNVGAVVQGAFDEIPVESFEKQMSMNYLSAAHASRAVIGDMKALESGHIAFVSSAAGQCAIWGYTSYSPSKFAVRGLAESLHMELMPFNIGVSLLFPPNTDTEGFKEELRTMPEEVRLIGDSAGLFSAQNVAKRLGNSIENGNFITTVGFEGWMLGMLTAGQVLNQISLMLLLNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3G7</accession>
    <name>A0A914Z3G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3G7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4797.t1">
        <property type="protein sequence ID" value="PSU_v2.g4797.t1"/>
        <property type="gene ID" value="PSU_v2.g4797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4797.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="41261" checksum="F1EC70D7D26AC523" modified="2023-02-22" version="1">MTRDEWEREDFFKFFTLLFQKRKVVPKVKKEWSEEDLYYAIDHGTVQEVMEIAGTLHASKKYTKEVRNRIYDQLVYVRELWHADPQPPKNNKLTLKVFGGTPWRYFHDFLRRKEFYNMEYLLMPTSSNGYMIYVVEVKPGNLATKRIKEYGIVDEKKNYMPCDCSFENLIVLCSRCNNYIQKQECLGNSEHKFFQRNLRCFKIEHGKEMKEILEPETVSLIMVQEESIDQKNGGIRRFDRNQDARKSSRRNRTPLPSIKNSDDNKSLQSQNEFNDDPELITENIPQRPPPRYQPRFDDFIDPYSPIIKQPIHQEPEENNRGEEVKVCDFAGGFFWSLASPRFSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3P0</accession>
    <name>A0A914Z3P0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3P0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7312.t1">
        <property type="protein sequence ID" value="PSU_v2.g7312.t1"/>
        <property type="gene ID" value="PSU_v2.g7312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF112">
        <property type="entry name" value="FEM-3 MRNA-BINDING FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="88"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="390"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7312.t1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53729" checksum="A5ADA24951B93323" modified="2023-02-22" version="1">MSAIYYCPENSMLIPTNAMGTIPVGAFISGAVNAHDYGHEYYAVSASYPPTFHHPALQPTTIHNGMLSDFEYNSLMAQMNRLTLSGSGRGQMPEWLFDEEGNFTVSLQDIVELDLFFICVRDKKGSQFIQDNFPSEDCSLRRKLYEMLFDSQSIYNLAMDMFGNFVIQKMITEAGKEYGQKMLHLLSMQAPDMAFNRFSCRVIQKAVDAFTPVMLEPMLQAFRGYVLSMGTDQSANHVLQKIIDTVPANDYRFIIDEMCSSGNMDRMICNKFGCRVVQFCLEKLTKGCNNNGDLVKDDCTEAELIRELMDKISRKAFRYSQDEFANYIVQYVIKHRALHVYRDRIIKSALIGNILSLSQSKYSSHVVEQAFECASDNLLPEMIKEVFHGKVNQKNGRDSLDQMLFDQYGNYVIQRLLNMGIQIRRGKRQGKAKWFDVLIQRISVNVQPLLKYSSGKKIIETVSAEVGYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4D5</accession>
    <name>A0A914Z4D5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin thioesterase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C65 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z4D5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7555.t1">
        <property type="protein sequence ID" value="PSU_v2.g7555.t1"/>
        <property type="gene ID" value="PSU_v2.g7555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016615">
        <property type="entry name" value="Otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013503">
        <property type="entry name" value="Ubiquitin_thioesterase_Otubain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="11">
        <location>
            <begin position="80"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR013503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR013503-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR013503-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7555.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32070" checksum="FDE232B5BF0DBC11" modified="2023-02-22" version="1">MSTEEQQKADQTLAQQLAESEQAMYEQSQQQIQEIEDEVRQTQALVGQKETIEAGLISNYDKDASPEYHQKALELSNRYSHIRKIRGDGNCFYRAVLTSIIEHVLHNRHELEPLTALCTGWRKRLMDQNFPELTTGDFCDATETLLESIKENLKTNDVLMDDLNQDGIANYYVAFLRLITSGYLRENEAEYAGFIEGGRTLDQYCIDEIEPMWKDCDHLSIIALVNALKTSLRIEYMDRSQAPSGGWHHDFSADGSEPKLYMLFRPGHYDLLYKKDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4F8</accession>
    <name>A0A914Z4F8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4F8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5134.t1">
        <property type="protein sequence ID" value="PSU_v2.g5134.t1"/>
        <property type="gene ID" value="PSU_v2.g5134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036793376" evidence="2">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5134.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="26159" checksum="40F40A12553FDC3C" modified="2023-02-22" version="1">MSNAALITLIITIAVAAIQAVPIPPAGASAVIPMNQEEMAANVKKFSEVYKLATQLMNLGGKFLNNAEGSAAASSTAVRGGGGGGGGGGGAFGDFGTDNGVLGDSIRPQFRGVPNYDSNSGGSLFERATRAFTGGSNYGPSAPSNNFGAVAAPPSLSEYGGGPLGSGTGKVQSARTTALDSILNTFLGSSLGGASGGSSGPSMTDFFNPNYKDYGRKTSQYGNNGGEGSNIEELIAALSRNGAKPARPEPESRNLFSQFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4M6</accession>
    <name>A0A914Z4M6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribosome-releasing factor, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4M6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g694.t1">
        <property type="protein sequence ID" value="PSU_v2.g694.t1"/>
        <property type="gene ID" value="PSU_v2.g694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.20:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="7">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g694.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15617" checksum="9F4911B1D4B254DC" modified="2023-02-22" version="1">MVPVSQVGNITVVDARTLNVQVWEKHMAGPIEKAIRDNELGLNPISMGESIRVPMPALTEERRRDLAKVVRGEGEDAKVAIRNLRRDANDTLKKQVKDKEISEDDERRAQDEIQKLTDKYVAEVDKLIAQKEAEIMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7C1</accession>
    <name>A0A914Z7C1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7C1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7782.t1">
        <property type="protein sequence ID" value="PSU_v2.g7782.t1"/>
        <property type="gene ID" value="PSU_v2.g7782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000093">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7782.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12127" checksum="72B66E09E8550F32" modified="2023-02-22" version="1">MAKSKGTLSKTDGKKRISRSARAGLQFPVSRIHRHLRKGRYAERVGNHGSIYLAAILEYLTAEILELAGYAAHDNKKARITPRHIQLAVRNDEELNNLFHGVTIPEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA30</accession>
    <name>A0A914ZA30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9178.t1">
        <property type="protein sequence ID" value="PSU_v2.g9178.t1"/>
        <property type="gene ID" value="PSU_v2.g9178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9178.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="10127" checksum="A0CDA79EF54C407A" modified="2023-02-22" version="1">MALESNAEYLAECAEVGDFDVRTRNFGKYTSKAERIENKKHGFDHTRRLVNNWRHNNMNQRNSKVFKVMETFFLLTEDEVEDPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAV5</accession>
    <name>A0A914ZAV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translocon-associated protein subunit beta</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAV5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7387.t1">
        <property type="protein sequence ID" value="PSU_v2.g7387.t1"/>
        <property type="gene ID" value="PSU_v2.g7387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036988488" evidence="2">
        <location>
            <begin position="16"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7387.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22356" checksum="6B7B86379E27A044" modified="2023-02-22" version="1">MRFIIFSLLLVLACAEDAEFVTKPVLNTARLLVSKQSHSQYAVENMDYVIQYDIFNIGDQPAVQVVLDDRNSFPTQSFEIVKGLLQVRWERIAPGENVTHSITLRPRNYGVFNYTAAAASYFPNENAKEVRVVYSTAPGEGYIYRLKDYERRFSSKIGVWIVYLLIAGATIFFPYFLWNTIQNKYPSTTVRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB44</accession>
    <name>A0A914ZB44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB44"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9535.t1">
        <property type="protein sequence ID" value="PSU_v2.g9535.t1"/>
        <property type="gene ID" value="PSU_v2.g9535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9535.t1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47618" checksum="1E2703B65FF61FA6" modified="2023-02-22" version="1">MAVFEKLESEYPNYAPIYSAEIERLSKAKKLPELKKMVEKLLEIIESKKVAEFFGVKSEFSEENLQKKEKMETKKAAIINALFFQANLFLDSFLKITNKDIPAIFRNGFKPKKDDGTENADKKADKSDNKECASIEKIDSKSKVFEDIKVVNVQDAKEAIDKNDGEKSTVKDGETNSINKKFVIQNDKEESADKKNFCSNDKISRNSVSSNDSFDKVEDSGIDSDDKTAFSSTPKKKESDDVASISETSISSDIKIAKNAVPKSNIYENETTSTLKNLITETVKTPNDSNEKLNAVASESESYNSQIIVNDQIPKESDPKSNIDNFRSKIASESEKIEKTENTETSSSEVSSEEVEKVFRDYMLFVDSTSENARIIQAKYAVAHERYGTALKQLEKIIIDKATTSDYLSTEKAVIEVRDCLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD97</accession>
    <name>A0A914ZD97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatidylethanolamine-binding protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZD97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9644.t1">
        <property type="protein sequence ID" value="PSU_v2.g9644.t1"/>
        <property type="gene ID" value="PSU_v2.g9644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000006">
        <property type="entry name" value="protein D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001858">
        <property type="entry name" value="Phosphatidylethanolamine-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01220">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9644.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21266" checksum="F99B613CD8252515" modified="2023-02-22" version="1">MSSTSPEVSEAFARHGIITDVIPKAPQDKLNVTFDNGLKLELGNVLTPSQVKKQPRNIEWNADKNALYTLVKTDPDAPSRDDPKFREWHHWLVVNIPGTNVGDGETLSEYVGSGPPEGTGLHRYVYLVYKQPGKLSDSEHGHLTNRSADNRGGWSVAKFAQKHNLGTPVAGNFFQAEYDDYVPDLYKQLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDC4</accession>
    <name>A0A914ZDC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDC4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9944.t1">
        <property type="protein sequence ID" value="PSU_v2.g9944.t1"/>
        <property type="gene ID" value="PSU_v2.g9944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9944.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18445" checksum="F24AAC04A2C64BFD" modified="2023-02-22" version="1">MINRILFNLILTRRLKLHLVKFVTSKKEAQICHLLKNLQNGLGVSGKLEDSLIRAAETNGPEDLIKPFELFEECLHLIGEEKSGEIKACLVDFKKVEKENNEKQKVIYGELIEIICDELMPEAYESEKLRKGQRAIIKDTKEYLVRNVIDNLVCLYSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRN1</accession>
    <name>A0A914XRN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aurora kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XRN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10652.t1">
        <property type="protein sequence ID" value="PSU_v2.g10652.t1"/>
        <property type="gene ID" value="PSU_v2.g10652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10652.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9823" checksum="E984743FC02B5B9F" modified="2023-02-22" version="1">MCGTLDYLPPEMVVGHAYDKSVDYWAIGILCYEFLVGRPPFETLSNSGSNDRARDLISKLLVIDPSKRINLEQVMEHEWVQNHVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSV9</accession>
    <name>A0A914XSV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0149 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XSV9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10049.t1">
        <property type="protein sequence ID" value="PSU_v2.g10049.t1"/>
        <property type="gene ID" value="PSU_v2.g10049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.740:FF:000001">
        <property type="entry name" value="UPF0149 protein YgfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.740">
        <property type="entry name" value="YgfB uncharacterised protein family UPF0149, PF03695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011978">
        <property type="entry name" value="YgfB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036255">
        <property type="entry name" value="YgfB-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002477">
        <property type="entry name" value="PRK01736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37528">
        <property type="entry name" value="UPF0149 PROTEIN YGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37528:SF1">
        <property type="entry name" value="UPF0149 PROTEIN YGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03695">
        <property type="entry name" value="UPF0149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101327">
        <property type="entry name" value="YgfB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10049.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15023" checksum="8B23A173D6E715B1" modified="2023-02-22" version="1">MAFGHELAQALRKMHSATSDALQDDGFLFQLYLPDGDDVSVFDRADALAGWVNHFLLGLGVTQPKLDKVTGETGEAIDDLRNIAQLGYDEDEDQEELEMSLEEIIEYVRVAALLCHDTFTHPQPTAPEVQKPTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUQ2</accession>
    <name>A0A914XUQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUQ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10693.t1">
        <property type="protein sequence ID" value="PSU_v2.g10693.t1"/>
        <property type="gene ID" value="PSU_v2.g10693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10693.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13516" checksum="D7B89692103C81AE" modified="2023-02-22" version="1">MQNPDYQDLKKRTQPDESESPIPLQNSMIIELSKKYAKTPAQILLRHLIQCGFNVIPKSTNEIRIKENFDVFDFELSDDEMQKLNNVPQKSRTFWLNFLAIHPEDPFKDERKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW73</accession>
    <name>A0A914XW73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10781.t1">
        <property type="protein sequence ID" value="PSU_v2.g10781.t1"/>
        <property type="gene ID" value="PSU_v2.g10781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10781.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="10398" checksum="C97FA203FAC01613" modified="2023-02-22" version="1">MAEVAGQFWGPPMFSPWGGGFGRGGWGRGGWGRGGWGGGPGWGGGRGGWGGGRGGWGGQNGGWGGQNGGFGGGGGPGGGGGNGGGGNGGGGGGGRGGGGGGGRGGGGGGRGGGGGGRGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW88</accession>
    <name>A0A914XW88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">F5/8 type C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XW88"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11497.t1">
        <property type="protein sequence ID" value="PSU_v2.g11497.t1"/>
        <property type="gene ID" value="PSU_v2.g11497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000007">
        <property type="entry name" value="Discoidin domain receptor tyrosine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="F5/8 type C" evidence="19">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11497.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17876" checksum="1BC4A47C49A1E6EB" modified="2023-02-22" version="1">METGEIGDKQISASSSFDLESVGPQNARIRTEKASGAWCPKSQIKYNSYEFLQISLNSTHIIQSIETQGRYANGTGSEYVNQYYIDYFRSGEQWIRYKNRTNHSLLSGNTDITTAVLQTLDPPIISSKIRIVPHSKERRTVCLRVELHGCKNFENHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX01</accession>
    <name>A0A914XX01_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L53, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XX01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12473.t1">
        <property type="protein sequence ID" value="PSU_v2.g12473.t1"/>
        <property type="gene ID" value="PSU_v2.g12473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052473">
        <property type="entry name" value="mtLSU_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33618">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L53, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33618:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12473.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14913" checksum="6DA8D88700B237B9" modified="2023-02-22" version="1">MCKMWESIRYGVRWKPMQRFALASRAINLKNVEKIQISLDPFHPNNNSLRYFWHVITTTKVKMTNPRMKVTTEIRNDGKGPFFVADLADKKKVVFKTDGMQPMDVVMRFNRVLGNPELGNSGLRKIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYX8</accession>
    <name>A0A914XYX8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYX8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10890.t1">
        <property type="protein sequence ID" value="PSU_v2.g10890.t1"/>
        <property type="gene ID" value="PSU_v2.g10890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10890.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="17113" checksum="5CE044F68E828B8D" modified="2023-02-22" version="1">MVINSRLSHADKDYLREQKGDDKYSKRPSRNEYSVDIDKNDYNDENFRQQQCDDRYNHSDRESRRYDNENENDYQLNSNQRTFHDPRNPSHDHSNDYGIDTKSRRGKNFQSDKNDYDDKDTRYSKTDKNDKTKTTKLSPISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZL3</accession>
    <name>A0A914XZL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZL3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13400.t1">
        <property type="protein sequence ID" value="PSU_v2.g13400.t1"/>
        <property type="gene ID" value="PSU_v2.g13400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13400.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16089" checksum="EC73498656C46377" modified="2023-02-22" version="1">MSITYGYIFYALRKRLRTIQLQEMAGGQFLGFGADLGNITTSAIETVIGVAPRNRNMISWEKPLLRKIEETAAEHASSLNDSEREQLQTILECVQPSSSGSQELTTMDDDIERPPSVLLEAVTMKFSETASSSSILEVPRSMPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y040</accession>
    <name>A0A914Y040_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y040"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12151.t1">
        <property type="protein sequence ID" value="PSU_v2.g12151.t1"/>
        <property type="gene ID" value="PSU_v2.g12151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000071">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="59"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12151.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30958" checksum="370659571D047DB0" modified="2023-02-22" version="1">MDVNATQPPPDSYFAGNAEWEVMNVTVRHMKFMEEGEYRAEIHYILHLHRRPIYYITVIVAPTFLISALSILGIFSPGSNDGPRSEKVSLGLGSLLALTVLLDIVAGAMPKSNSVPLLGYYIIAVIVLCAVAVGISMGFLALSKQFIQTEKMPSAMAYKLLWMEPKKRRIDYWQTSDYVDNYEMQLPKFPDLIAIYNQIREIAQAQTTFRKKLEKQKWHGMVESEWNRLFSRFDYFFLFLFQGLNLIVLMLFLRNAWLPIPELPADFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0K7</accession>
    <name>A0A914Y0K7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0K7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12316.t1">
        <property type="protein sequence ID" value="PSU_v2.g12316.t1"/>
        <property type="gene ID" value="PSU_v2.g12316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12316.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17971" checksum="3ED128A05FAFA846" modified="2023-02-22" version="1">MYAKNIQLAPGVPYLKIQGKVLHKMPKTYQPYGNNSTFGGQNYIVDSGIATTSRLAALEKNNIKLNEDLMLELDQMMREKNAFAKSYIMLKDTIEKVKGETDENEPLTELRLVFKNKPDASRNYDKVEAENEVAFVYKPGPNGEIPRDDINMILKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0Z1</accession>
    <name>A0A914Y0Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 474</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
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            <taxon>Panagrolaimus</taxon>
        </lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0Z1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12453.t1">
        <property type="protein sequence ID" value="PSU_v2.g12453.t1"/>
        <property type="gene ID" value="PSU_v2.g12453"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF68">
        <property type="entry name" value="ZINC FINGER PROTEIN 474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12453.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13739" checksum="821DC33143C36555" modified="2023-02-22" version="1">MSNFTPGPPKAKKPAPTVYCFICGRQFGSKSIEIHIPQCLKKWHIENNKLPKSQRRPEPVKPEIIKTGETIDVEATNEAMWQSSQANLVKCEWCGRSFGPDRLAVHHRSCTKENPAKRVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y148</accession>
    <name>A0A914Y148_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y148"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12512.t1">
        <property type="protein sequence ID" value="PSU_v2.g12512.t1"/>
        <property type="gene ID" value="PSU_v2.g12512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12512.t1"/>
        </source>
    </evidence>
    <sequence length="462" mass="51790" checksum="C218AAB5AAFC8E2E" modified="2023-02-22" version="1">MSYFNDAPAPHGRIAVCRVYNRQTGLFEIVPASNPPQGEVFFIEAPPPAPMPMNYHGYENVPQMQSPVYPVPMFQNFQYLPQPVMNPMENEYAEPRDRVISFDSVSSIDIQPSAAPQSNEAQSQNGESAEVQEPSTSGSGSVSASTAPSAHENDTAAAQDNIYCREDGPLARHGNETISRRLPSLIQRHASGTQPWVTKILVEQTRIIVSLDTDENIIISCDCINLGRLMCECQAAPAITLESNAFKKQLFFINNETLGNFFKFSKAVYFTGQFAVENLERLVPCLRARKISVHRWTITHAGRLGSITHAGFPATIENLYFDTRGTDNVSFIDNLSRVYKDVYEDVHRGRPFLVNFQLIVDDFCALGDALDAQIERIFRMLKADVPTTAAVLFSIPGDNDIYAELSNLRFLYSHYGPVEALDGTNYLVDYWKKEDGDKTLVFGFKSRRAIPVRPEIITIERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1E2</accession>
    <name>A0A914Y1E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1E2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11645.t1">
        <property type="protein sequence ID" value="PSU_v2.g11645.t1"/>
        <property type="gene ID" value="PSU_v2.g11645"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11645.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12884" checksum="32BCEC36F5124C84" modified="2023-02-22" version="1">MAIVDLQNHKIEYYDSMLGNNRQVFELLLSYICAEMKDKKKQEICTNQWTRDSRKDIPTQQNGSDCGMFACKFAEYASRRAPIDFNQKHMPYFRKRMVWEIFQQKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1I9</accession>
    <name>A0A914Y1I9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1I9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1406.t1">
        <property type="protein sequence ID" value="PSU_v2.g1406.t1"/>
        <property type="gene ID" value="PSU_v2.g1406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1406.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13869" checksum="778B33E63418743F" modified="2023-02-22" version="1">MATTKSLILMTEIYGGCHEFYGKVSCESGDAILPTAKVGLWEADDSFFSSDKWITAAPIGPDGKYLINACVWDYALVLKLTLAQVYLEFREACPNVVYSYAHYTKPGKPFAYQIFQNGHLAGIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1T6</accession>
    <name>A0A914Y1T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCAAT-binding factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1T6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1178.t1">
        <property type="protein sequence ID" value="PSU_v2.g1178.t1"/>
        <property type="gene ID" value="PSU_v2.g1178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="370"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="872"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1178.t1"/>
        </source>
    </evidence>
    <sequence length="895" mass="102844" checksum="BED25D4DCF80D2D9" modified="2023-02-22" version="1">MSSEKTKHNKATKRENNFPIVRINEGEKWYEHDYNEKLDPKAKQDVTKLSEAEAMAAKLMERDIERAEILRKQKGQSDAGWISKVIKSGTQADRISAVQLMTQMEPVHSLTHVNSLIELLKKHRTREGIPILSALKEIFIDELLPENRKLVSFKFRPITNLEKLSSGNVQTVEKRLILWKFENDLKKCYEQFVQTLEIIASAQIETVAIHACRIISELLTKKPEQEAILLATLANKLGHPNKVVASNVSDFLYTVCNEHPAMRFTVVSEVERVTFRKNIPLKAQMYAAHFMSRIVFSEGDSELSVKLLQIYFTLFKLLIKAELDNHRIVAIIMIGANRALPYAKDKVEALMPEIDSLYKIVHVEKFSIALAALKVLFQMQSLSKSFSDRFYATFYRRLLTIHSSTHDTEFFHLLERVILSDESIERVKAFLKRMLQLALCNSPAFATAALLLYFKVSQQKEGIIKLTKKANNLLGGNVKNDLDSDDEEEHYVDVDDTPKVEKKPVVQKIIYVKGKAVTKLKEQILKEKHTAKKPEVNGIQGQGWIHRKDPTQKSETIKHLGYNHEGRNPLFANADTVVDTEIFLLSQHYHPTVAVFAQNIIDGKPIKYNGDPLQDFTLIRFLDRFSFKNPKVSTFEKAPLFQHKYNPRGIRKLGPSSQEYVTKHIDEIPIDERYLHHFASMKLQNASKKKKDDEDFDDIASVDSDEFETIMDRFEPGEANEEFDVNFGEMFGPEKIRDKKGKKQKRKGDDDEDDLDVDEAEFMYSDDEGLDDDDDEEEEIDGVGDNDEDMDEDDDGVEVDDDSEDELDDDDIGEEDEESDAGSPKRKNKFDLDDMDSDEEVDDYSTQLSYAKDALQSADKIDDFMDFEDEDASLQKNKKKQKVKKPKGFKKRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2I6</accession>
    <name>A0A914Y2I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2I6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12002.t1">
        <property type="protein sequence ID" value="PSU_v2.g12002.t1"/>
        <property type="gene ID" value="PSU_v2.g12002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="93"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12002.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19283" checksum="18ED4C7BAAE3FBC3" modified="2023-02-22" version="1">MDPTFGYIILLLLIDSALRLLIDIIYHRKSYSEKGLLELIDYSNQCGWFQLMDDLLLNDFEDIEMDGLPRCWILARKRNLECEKFLRQKVGDVAVTMIKQNNSRGCEDLLSIPIEALLELIDDENVNWQNGKNCFEVIFAWSLQNHQSAICNIKEFFKVVRFNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2K2</accession>
    <name>A0A914Y2K2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 86</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for proper chromosome segregation during mitosis and error-free mitotic progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2K2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13679.t1">
        <property type="protein sequence ID" value="PSU_v2.g13679.t1"/>
        <property type="gene ID" value="PSU_v2.g13679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026570">
        <property type="entry name" value="CCDC86"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0164">Citrullination</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13679.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14703" checksum="91615CC42E869CA1" modified="2023-02-22" version="1">MKPSASLQVAKDPRGKPKSGRVWKEPATRDNRLTNIVKAKNLKSSWEKKMKQKADKEQFKTAKEEIRNKIHDEKKALGEARKKKAEQRKANERKSEVVQVIRNTNKLRRANKKLLRKVEKRDTTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y367</accession>
    <name>A0A914Y367_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pao retrotransposon peptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y367"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13677.t1">
        <property type="protein sequence ID" value="PSU_v2.g13677.t1"/>
        <property type="gene ID" value="PSU_v2.g13677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13677.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20413" checksum="D3A015E719A72986" modified="2023-02-22" version="1">MQKLFKLALKWDQPLTADQEKEWIEILKDWKGVVQIPRKFVNDKFPNPAEIQIHCFADASQFAYCASVYLRIPTSNGCETPLVFAKTRLQPLSRKLTIPKMEIMGIWLAAKISSFVAKELNLEASKKFVWTDSQISYHWFQKWPKDVFVSNRLKEVVASKVECSRFLVEWPKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3T1</accession>
    <name>A0A914Y3T1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3T1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13431.t1">
        <property type="protein sequence ID" value="PSU_v2.g13431.t1"/>
        <property type="gene ID" value="PSU_v2.g13431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21646">
        <property type="entry name" value="ACTMAP-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13431.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12478" checksum="BB6B13E282BBAA1A" modified="2023-02-22" version="1">MADIPVVTTDMEKCGPLLWTRLECAIETKGETARGRIYFHHAEAHLQKGPTCGFVALILAARAVGLEPEEKDQVDITEVMAWAKMCQFTKAGEMFSGLFIINQTTVFNNNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4P7</accession>
    <name>A0A914Y4P7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4P7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1517.t1">
        <property type="protein sequence ID" value="PSU_v2.g1517.t1"/>
        <property type="gene ID" value="PSU_v2.g1517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1517.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23366" checksum="DC53AB1D67836440" modified="2023-02-22" version="1">MAVKLFDKMLADNPKTNGFVRFLTDDDLKLIRCLINPPAMFDSNKKWNLPISQDKAYIFNIVNNIRNGLDVDKLDYIYRDGLRCGMNKYAINMNIVKRIIKSGVVGKEHREEGTFCCLKYPQSNAGEIKAVFKSKIELFQNVYHDKKVLANDEMFKKALKLAGPHLKFRTKAGLQISLEKCHEDLNAYIQLTDDLLYEKVINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y550</accession>
    <name>A0A914Y550_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y550"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14364.t1">
        <property type="protein sequence ID" value="PSU_v2.g14364.t1"/>
        <property type="gene ID" value="PSU_v2.g14364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14364.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18352" checksum="7B724CEE3BCD0040" modified="2023-02-22" version="1">MSSRSSANTLEEREPSATPIAPRSRSTSASNIETARQLFVEQLDFLDKEKEKLIQELPPLAPVASSEDLSSSEAEHSPSPKGAQKESKRNSPSSRRFTDMDENGEYAIDINSPPVLCKLPNSFHRSRIVGDYRRRLPSWSQRQHFAEDQIIFKLTFEECEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y562</accession>
    <name>A0A914Y562_9BILA</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
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            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y562"/>
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        <property type="protein sequence ID" value="PSU_v2.g15336.t1"/>
        <property type="gene ID" value="PSU_v2.g15336"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995:SF4">
        <property type="entry name" value="PROTEIN CBG09882"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG18546"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036826581" evidence="3">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15336.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22529" checksum="1D2C41A600EC11DD" modified="2023-02-22" version="1">MLNLCYILYLFNYLILVYAVTPTPTINPSQQCPCITVPGMPGCLQFDSRLQATTLDEAMNSFTDLTLEESQKVEEEKNDIDCTTKQCKTCKEYLKKKLKDIGMLPASTITSLTANSTVQCSKYNFVRKGDVGKDSSDDDDEDDDSSGSSVEIKEIEKLKGKRDKIMKKIEDHKRHLKRIRRQASAATDMGVDATVMEVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5D3</accession>
    <name>A0A914Y5D3_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="WBParaSite" id="PSU_v2.g1445.t1">
        <property type="protein sequence ID" value="PSU_v2.g1445.t1"/>
        <property type="gene ID" value="PSU_v2.g1445"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1445.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14539" checksum="EA7774109C0F48CB" modified="2023-02-22" version="1">MIRHNWISEDAALKLKEKCPRPPSPDEILLFSLPIGDMIVKLEQMIDAAIKRHKDHSEDVSCRLIYNSNVTYFVSHFAIVLHFAKFFKVQKSDKLYNYSVPLLLGIAMDRNQDIPVRRRALVEMV</sequence>
</entry>
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    <accession>A0A914Y5K3</accession>
    <name>A0A914Y5K3_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5K3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12963.t1">
        <property type="protein sequence ID" value="PSU_v2.g12963.t1"/>
        <property type="gene ID" value="PSU_v2.g12963"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12963.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34595" checksum="509481265113D523" modified="2023-02-22" version="1">MSQTHVELSDIITPLKKIVRRPSSPSSKSKASSPTLNAEPQTAASTSTLNDKGTEKVEEKQRHSILGLFTRKHQPPTSLENLPLKVLHRINPKSDSATTPSGSLTFLQRLSFHTKQSPTTPHVSFPNPQTDSNILRPNELLLPVKEVDSTITDEGTSDTHTSNGELVASPIPDEQWFEPPVQTTEIDFRPSALKNSRLSTTHQEIVEAESVRDATIRELEEFLVEFRNGKLRTLKDKDLAAMRLMHTEQSAISIFQMQIHNQLMEYGNFADTMDFDEQYCKLGEKLDHLHNLMENFGGLSNAKTPIFE</sequence>
</entry>
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    <accession>A0A914Y5T8</accession>
    <name>A0A914Y5T8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication termination factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Replication termination factor 2 domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5T8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15563.t1">
        <property type="protein sequence ID" value="PSU_v2.g15563.t1"/>
        <property type="gene ID" value="PSU_v2.g15563"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15563.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13470" checksum="D753561B033D2E40" modified="2023-02-22" version="1">MDLIRFDDVYKDYNETPFLCPITSLNMNGSYPFVVNWECGCVFSEKALQELKPETCHGCGGNIDKANIIQLNPEGELLKEYEAKVAEELLAKKAKKSAAKADIVEGPSVNPEIEKGNIFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5Z1</accession>
    <name>A0A914Y5Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="PSU_v2.g15613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037563676" evidence="1">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15613.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22565" checksum="B7362E06AAB50D17" modified="2023-02-22" version="1">MKWIFFAIILSFFVDPVFSRSKFGSIINHVFSCDCFIRGNNGNSLDELLRSLSFETNVTTPKFHPKLFVVHPSRDTKPTMPPILTTPPLGIQQPIKQKENFLNTLISLIKESQQKLQDLGWIQADQDIPKPTVMQPPTIVQVAEESPNLFSIEQGSITRNIVRIGRFLQFADKFDCRCAGDLSSLVNAKRFVRFTVAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6H7</accession>
    <name>A0A914Y6H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo-like helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6H7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1486.t1">
        <property type="protein sequence ID" value="PSU_v2.g1486.t1"/>
        <property type="gene ID" value="PSU_v2.g1486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1486.t1"/>
        </source>
    </evidence>
    <sequence length="524" mass="60601" checksum="984A59284680ED91" modified="2023-02-22" version="1">MKQNPEPKIVKLYHQLFEEENLNVVKTDEFFLLRPHLQHLGSLFNGWPDDETLQKKKHIIQALISSILRILEGEQGLKVFNACQTLGVITNFVGKKVESIPQAQCLLLPGTPEDFAKVFSQRCRDVIIGDSSLTLKTCFLNTLLTIWSSFPKCLNNPLIINFCILLQLVEESKQNQFKKRLSELEDNIGIIPPHTHDHIITDQEQQISNGNNSNVFSLFLSFSSFVFADFDSKQQQDQTKLCLLILWHIINEPYVQNAIQDMHLSTNISLYKSPMLHRSASFAPISATPITLSTALLELLTDFNSTHLKHNFPFLHYHLSLSITHRILIYHKKCKIRLRSWRPLFNSLVSIINYLSQNLTKLPNDEAFHLLYRSLLVVNFFITYGDTFLPDAAAYDFLYYEISRQSTVFARLGKICKNDDEEQLFQVDKTCECFPKVANQLINILSIIEHIRPKLEVLAHSYLTEEQVINIVQQCFNDLTLKLYEGLENVEFKDEKNLENFLESLTEDMPHSVNAFWSEKIDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6M6</accession>
    <name>A0A914Y6M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6M6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1330.t1">
        <property type="protein sequence ID" value="PSU_v2.g1330.t1"/>
        <property type="gene ID" value="PSU_v2.g1330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1330.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12588" checksum="C057096940C863F4" modified="2023-02-22" version="1">MEIEEGEIISSPEIMNACVYALVFIRAIVIAKEKVEKNKVEQICKLFRVTSEMVFSDEILEYAGNTIGNVEILVVIAEHWKQGISLSTLLKKVAETTPSPSPPPTSTILLELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6X0</accession>
    <name>A0A914Y6X0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6X0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15958.t1">
        <property type="protein sequence ID" value="PSU_v2.g15958.t1"/>
        <property type="gene ID" value="PSU_v2.g15958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="13">
        <location>
            <begin position="285"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="467"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15958.t1"/>
        </source>
    </evidence>
    <sequence length="503" mass="59124" checksum="5C6FEF08DC5B9E73" modified="2023-02-22" version="1">MALSSTNYAVRKKDKYGGETIIDSKSYEESQQNLSLYQFPPTEIISLKEFEEYGRTRMNVLKKVEQLREKFRQGSTEYKQAFSKEIDKLMPLATGKCFKNNLEDERRKDRISHCILRMAFCQSPEQTKWFIQQEVELFRSRFSIETQDNILNFLRVNNFELEQVQLDEKRHFSKQLSAGNKIPEEHIDKTEFWKVEFSRAFELIRGRKVFLWKGMIYITFKELVAVIATRLRLVMSKAMAKEAMNMGRLNEEERLLPMLRKLTKIDTNSGYQPKNANEITPQMVDELSKKSFPPCMKHIHSNLRQEHHLRHFARRQYGLFLKDAGMSLESSLEFFRKEFIKKIDANKFDKEYAYNIRHCYGKEGSHREGSGYACTKIILTNPPAAQDCHGCPFRHCDPGLLPQRLQNMGLTNDEAQKVSAISNQKRYDIACARFFEYQHQMEEGALGAVITHPNQYFDASRQIYDGKRSRNAAKNSQEIHLTVKKKEQKQEPLKDEFDEDMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7G3</accession>
    <name>A0A914Y7G3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZNFX1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7G3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15215.t1">
        <property type="protein sequence ID" value="PSU_v2.g15215.t1"/>
        <property type="gene ID" value="PSU_v2.g15215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="2">
        <location>
            <begin position="166"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15215.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="30783" checksum="B97790031F15A610" modified="2023-02-22" version="1">MAEIKMKDRIRAKLFHYLIEILLFGYENHLTKMDDYESDVHKIISALKFKDVFLEMTKEKFAQLEKIYIDLQNLESQKAKKKAKVPFTNRKFTGNNGLPPENYRFLSLIPSPEELKINFQPYLRSAKIDEPYFDSEHYLDVHFRLLREDLISPLRSGIEEIKTGKTRMHLYKSVKFIELALHLPSGEYIHYVKIHESQIKLCKKTLKNFSLLCVSSDKYQNEFFFASVVDREDCLMYDGKIGIKFENDYEIDMSKEYQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y845</accession>
    <name>A0A914Y845_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y845"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16368.t1">
        <property type="protein sequence ID" value="PSU_v2.g16368.t1"/>
        <property type="gene ID" value="PSU_v2.g16368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16368.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18344" checksum="65A38EA5FBB6BD19" modified="2023-02-22" version="1">MPFYRAAWQVSKTLLGNPHTGIHKLNPKDNSSGFVYVGLDGNDFSSEVFVLESSRFKLQEPAYLFFDVYQRSMGIQLKVCINGFEDCPYSNPPLKASEFWLQDQQIYLSTGSEKIYFLASKVRQNLYLALDNIRLQTIDGHSYCPEKYKQPATEKLFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y980</accession>
    <name>A0A914Y980_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y980"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15997.t1">
        <property type="protein sequence ID" value="PSU_v2.g15997.t1"/>
        <property type="gene ID" value="PSU_v2.g15997"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
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    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15997.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11677" checksum="4BCB0CDF703EB884" modified="2023-02-22" version="1">MKSDAGVKFHVLLTSYELINMDKAILSSIPWEALVVDEAHRLKNNQSLFFRTLSEFKINYRLLLTGTPLQNNLEELFHLLNFLSPDRFKVTVAYDDQRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9K1</accession>
    <name>A0A914Y9K1_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g14220.t1"/>
        <property type="gene ID" value="PSU_v2.g14220"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14220.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8460" checksum="FEFEE1897C71767C" modified="2023-02-22" version="1">MDTDYGRSEGSLHGACPVVKGVKVGLTLWVRSVGQELRWHCPLKQKDPFPLEPLIQPKWLKKDWPLQFGFPLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAD7</accession>
    <name>A0A914YAD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16244.t1">
        <property type="protein sequence ID" value="PSU_v2.g16244.t1"/>
        <property type="gene ID" value="PSU_v2.g16244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
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    </dbReference>
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        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16244.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16237" checksum="7E712698CE3F4E9D" modified="2023-02-22" version="1">MNVYFQDWVEFGDNLYALLEEQVFQQEGEKRCIEFGGHLVSIHSKEENDFVHKLRGNNSVWIGRSKIAKPGFEGVYSWTDGSSIDDFPPPWDKPNEKYPDCVFMPNSVNSNGEWSDYFCDQNLPVAYSPSPAFAICKKPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB32</accession>
    <name>A0A914YB32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB32"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16623.t1">
        <property type="protein sequence ID" value="PSU_v2.g16623.t1"/>
        <property type="gene ID" value="PSU_v2.g16623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037846979" evidence="1">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16623.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21321" checksum="4B0796AE6E1D8182" modified="2023-02-22" version="1">MKQLFLFVFLIINFVGSIESATAANVYHGNRRHWTIEANGTTHIALHILKEPVRLIFPKTKTFPQLLSGLKLYSPAGNEKCENATNILKFTLLITDLYDIHGEIKVVSNRLRAYLFEKCAGGEGPDHYDSPLIDIRPADIENDNSRLCPDAGIPLQTYKNDDTKYVVELEASGNLECQVFMELKMSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB35</accession>
    <name>A0A914YB35_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YB35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14702.t1">
        <property type="protein sequence ID" value="PSU_v2.g14702.t1"/>
        <property type="gene ID" value="PSU_v2.g14702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="294"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14702.t1"/>
        </source>
    </evidence>
    <sequence length="498" mass="56025" checksum="8E72ADC2EF04F11E" modified="2023-02-22" version="1">MSEAPQYVLFEHGVGYAIFKIKEFEDIGEAIPEVEKSVTDYQRFNSIVQLHAFEPFKNTEAALDNCNSISEALVHEDLQSFLDANLPKKRKKCLVGVTDPKMGGSISESLGVKCIASGVVPEIVRGIRFHFDRLVKDLPHHSLNKAQLSLGHSYSRGKVKFDVHRVDNMVIQAIALLDQLDKDINLFGMRIREWYAFHYPELAKIVPEQYKYIKCALVIRNRLELDDERKANLLEVLETEEKVEEVVEGARTSMGMEITELDLKNISKFAERIVSLTDYRNLLHDYIKDRMAACAPSLTALVGEQVGARLISHAGSLTNLAKYPASTIQILGAEKALFRALKTRSNTPKYGLLFHSSFIGRASTKNKGRISRFLANKCSMASRLDCFSDAPVPTYGEFLKQQVEDRLTYFETGTIPKKNIDVMKEAQDAAEAEKDEAPKKARKAHKKVLKRARAAMDAEQPHQDGGAKGKKEKAVEEEPMEVEEKPKKKKKKSNAIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBX2</accession>
    <name>A0A914YBX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBX2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16786.t1">
        <property type="protein sequence ID" value="PSU_v2.g16786.t1"/>
        <property type="gene ID" value="PSU_v2.g16786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037552053" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16786.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14166" checksum="69C4E3776B654EF3" modified="2023-02-22" version="1">MLHWSLIFIFAFLIVSIQSSEKALPLNFFVATNSFEYMEIGADGKEVPKNRDDKILMVGTDFGKIVGSAQSYCRHINPPAEQTILIKPSELKHYPFEDLTINKTKQLLPIEDWECAAPHYGFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC33</accession>
    <name>A0A914YC33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC33"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15037.t1">
        <property type="protein sequence ID" value="PSU_v2.g15037.t1"/>
        <property type="gene ID" value="PSU_v2.g15037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15037.t1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42725" checksum="DD812F4583843A73" modified="2023-02-22" version="1">MALLNVVNALIENNSERHRDYLLEKFYHLAEELGGSICIVGPNDAKLSSPRKDDRFYESVNDSDYHGTLYRFIENILILSYPDCEINSLNLKSASHVVDQCYDKFVIEIQDKSRKCLSSGRKFIIPKCRLPLLSRIFLLKHLLSIEDSLICGPRAAKKARTLSTLSQLVNDGQYCHFQIILEVVTSWRHRLRSEDLDDLVIDLVKVNRKILKKDDKLELFMRILGRCLIDKRDIASADYDELWNWAISLLQIPAIQEAACIAISGIIHYYEEVLTAKPDDLFKVLIFQIAQFSVYSKPVLDLIHLVITKFEFDERASFRVDLQISIPEWTFRSQLLYAILKFSPYNENVENLIMAVINYHPQEVHSTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCY5</accession>
    <name>A0A914YCY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCY5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17154.t1">
        <property type="protein sequence ID" value="PSU_v2.g17154.t1"/>
        <property type="gene ID" value="PSU_v2.g17154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17154.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30913" checksum="7180CCB990186B18" modified="2023-02-22" version="1">MFFFRSFISTRPTSKQLSGQRLTEFSLSAVFAPNGKIENQSLQLQWSEATPNQPLPYQSFGGGDNNLYDEIQLTDHPSAAFHQRSLSTFDSASSGWSRSTGYVTPDVFATSVSSLSSSATAATAATSPQQSTKSKICNRRCSSSGPASFSDQMVLYVSVDLRVAFFEWPGLIVRKQIVKEVRNDLTVLEVLQHLIKCAGIVLTPAMNGETARLFCQRSARNGKGRFEEIDYLQWRCALLAEMNSVQIQFVLDFTDTEDATSSRASSSSSSICPIDMEFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDB9</accession>
    <name>A0A914YDB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17291.t1">
        <property type="protein sequence ID" value="PSU_v2.g17291.t1"/>
        <property type="gene ID" value="PSU_v2.g17291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17291.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15516" checksum="748F7631E354162A" modified="2023-02-22" version="1">MSFGRFLLYFFAQTLGAFIAAAMIFGIYYDAINNFDQGTRELFGKNGTGIVFTSFPQPFLSITNGIFDQIAGTALLCLSVKAIIDKNTAIPYYLHPLLIGLAVFVIATGFAYNGMGSINPARDFGPRLFLWVAGYSWEAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDC0</accession>
    <name>A0A914YDC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDC0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18221.t1">
        <property type="protein sequence ID" value="PSU_v2.g18221.t1"/>
        <property type="gene ID" value="PSU_v2.g18221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18221.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18175" checksum="51D95A752713777B" modified="2023-02-22" version="1">MEPEIMKFQASQKLLNPNLSSAGTHIERINLSPLEHNKLKILVKLFVDKNELKNVKLEFEEQLSLQQLTPIIFEKAELSSENYDLQSIDVLDKKSDEYITVNDEYLLQTFDKFQVHLVKKEQHLETVAIVSQSDNEEQQKLSIDTSKVKTIKQLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDY4</accession>
    <name>A0A914YDY4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amine oxidase</fullName>
            <ecNumber evidence="7">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YDY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17642.t1">
        <property type="protein sequence ID" value="PSU_v2.g17642.t1"/>
        <property type="gene ID" value="PSU_v2.g17642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17642.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13851" checksum="541727EEB43E793D" modified="2023-02-22" version="1">MDLARYFGDEVLHPIDYIDKDWHEEPFSPGCPVAVIPAGNMGAFAHIREPFSLIHFAGTESATLWTGYMSGAVQSGLRAAHEILHNFKSKHVNAQHLKDSIYDPKYKRPQDWDFTYSSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE78</accession>
    <name>A0A914YE78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17741.t1">
        <property type="protein sequence ID" value="PSU_v2.g17741.t1"/>
        <property type="gene ID" value="PSU_v2.g17741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17741.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47596" checksum="13A2090DF0F28CB0" modified="2023-02-22" version="1">MDEFTTSCPIGNTASIYKMAGFYIRLMNLPLDMISQLDHIMLACLAHAVDVMGDLQEIIRLILLPQLKKLELEGITFRYQGAEKNFKVILYRLSADNLGFHQLTGLNRCFSGNNPCWMCTETAESLRTIWCLNVRRNRSRHHYDHLISNGNDEQRLAYGIKSDCCLNELQYFHCMENFSVDYMHDLHDGHFLRLIPRIVRDAIDAGFPLPIINNAIVGFGLVGNDGNNPLRPIYLPAQIPENGDNLSGYTAKTCGVLVRLFPLMLKCAGIRLHTPSWLVFMKLQRIIDILYAPSITEATILMFNTLVEAYLKDYIAIRGKMTVKPHKLLHYKAVMEEMGPLRHLATFRYEGKHSHFKQYANVNRCFKNLQTTLADKNELMFARTLMKMKARKFLNLILLSLNDRCQFSWLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEI4</accession>
    <name>A0A914YEI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17861.t1">
        <property type="protein sequence ID" value="PSU_v2.g17861.t1"/>
        <property type="gene ID" value="PSU_v2.g17861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF4">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17861.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32708" checksum="F45E05EE561E106E" modified="2023-02-22" version="1">MIRQRQLTSSELISAYISRIRIINPVINAVVEDNFEGAQKAAADVDVYLDQLDKNSDEYKKLSETKPLLGVPFTIKDTYSVKGFRCTAGIYARRNVVADYDSDVVKNLKEAGAIHLAITNVPEAAFWFECNNRIYGRTKNPYDTRRIAGGSSGGEGAIIAAAGSVIGVGSDIGGSIRIPALCNGVFGLKPSEGAISLNGHHPNFKGGYGKRMCTSGPLCRYAKDLSIFFRVMAGNDVAENRFRLSKPVSMNKLRFFYMEGINSFMIEPLDKKVKATMIKSVKYFEKKYDTSVFSLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEZ8</accession>
    <name>A0A914YEZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEZ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1885.t1">
        <property type="protein sequence ID" value="PSU_v2.g1885.t1"/>
        <property type="gene ID" value="PSU_v2.g1885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="59"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1885.t1"/>
        </source>
    </evidence>
    <sequence length="430" mass="47203" checksum="467DFE8C63A3513B" modified="2023-02-22" version="1">MLNEYRIGNDSEIPHSSTSTKLPPGVIYDSRASTTEKQKSTFSARARTWIRFLLIGITLLCLTSLWSNILAFNFVMICLKSDAESNETLTSNTRIPQFSTEERTLLTSAVAVAALISNFFILPILTLMGVRTIFTVCGGISVIATAFMPLGIQTGFYSALLLRLLQGIAFSASFPVIGAISSRWAYYKQYGFVVSTLVGYVQLSPTISMPTSGALCESDLGWQSVFYGHAMVTGILFIIFCLIYRNTPSKHPFVTAIESTKIAMNKAVQTKSESRKIPYFEILKTPSVWAVWIASIGNFTFVNMVFLYSPTYFHNTLGMEVAESGLSAALPAGLEFLLKVFCGFISDKIKCFSETNRLRFYNTIAYFGASGVLLILCFIDPSKNSTTCFLLLSTATALLGFTTGGFFKAGPLIAKQYSQFVTGNVSLGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFW9</accession>
    <name>A0A914YFW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFW9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16242.t1">
        <property type="protein sequence ID" value="PSU_v2.g16242.t1"/>
        <property type="gene ID" value="PSU_v2.g16242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037619501" evidence="2">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16242.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9823" checksum="043BDD20542E0D96" modified="2023-02-22" version="1">MFKIIICLLLFGASVFCKPLEFDFEKVENICGISPALEKYGANNTDRTLEGPVSKLGDWPWVVSLESGGSLCTGTLISDKWVLTAAHCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG65</accession>
    <name>A0A914YG65_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19293.t1">
        <property type="protein sequence ID" value="PSU_v2.g19293.t1"/>
        <property type="gene ID" value="PSU_v2.g19293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19293.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12632" checksum="5B78935975A14204" modified="2023-02-22" version="1">MFDAASGIADLARAQRQLRGIGGQQATVVVEQAMHRPRRCRLAGVPQFTAAIVERLRIQQQATSHAQRALLVGQQAHLQRGIAMHLQRAAIVAQIAPGLQRAHSQATAAVVETVACGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG69</accession>
    <name>A0A914YG69_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG69"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1831.t1">
        <property type="protein sequence ID" value="PSU_v2.g1831.t1"/>
        <property type="gene ID" value="PSU_v2.g1831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1831.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19806" checksum="1635154DB472A693" modified="2023-02-22" version="1">MNQILHFRLNLRHFRIDKLFDPKKQFIVDGKLIIKCEGYIIREESHPKLKEIDDSGLHPVQESKDLWENSNEKTCHINVNGKLIYLHQEIFNHLFPESFRQNPVIFGFSFDSVELAIKFNYDFRLVYPLTLEESLEIFKFMKIYGRKGIIHDFERFLIEEINEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGL0</accession>
    <name>A0A914YGL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1801 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17925.t1">
        <property type="protein sequence ID" value="PSU_v2.g17925.t1"/>
        <property type="gene ID" value="PSU_v2.g17925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038101678" evidence="1">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17925.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20468" checksum="F0D12DAEE329D91B" modified="2023-02-22" version="1">MSAEFGRKNCWKLFYLLFFEIFVSGCWSTSLKNCPMKTVKPIIERAIESAGFEAPLQMQIIRRIMEDLYGGSWGVLIIKNPQLISTSVHWTIPDHKHGDGSPAFCLYVKNGWQYNIFKTGNVDTDNRLTVEDVVQKLRESKQRLAKLTVTEFDQKIAQAFRRRRRLRNDGNAFQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGP1</accession>
    <name>A0A914YGP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGP1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18622.t1">
        <property type="protein sequence ID" value="PSU_v2.g18622.t1"/>
        <property type="gene ID" value="PSU_v2.g18622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18622.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22484" checksum="2A74F6EC8960A97E" modified="2023-02-22" version="1">MRMTRRQIEDSNEDDDGIEVIERNHQVSGPRSEEEESSSQPTRSYQNISSISIDSLTPKKQFKDDATIIKEIQRHAGAQDSGDTASKSSLRSYTPEVTSETEIPVKVHILRLDSNMLLDVPFIREPINEWLQDHKIPPYIPHEKPGGDWHHLDEQGVQLKFSDIPTVSGSSQSSSTLSHENELSESEVELVKEVVNNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH96</accession>
    <name>A0A914YH96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18698.t1">
        <property type="protein sequence ID" value="PSU_v2.g18698.t1"/>
        <property type="gene ID" value="PSU_v2.g18698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18698.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20342" checksum="A2A94407EB6BE35F" modified="2023-02-22" version="1">MSDLNINRYDSKYQCVWDFLHAKDGAILISGLTLLGCLLSVIGFFYQDYTSFGAYFFIVYTVIETLAFSGVLAGIYYTEPFWLLLCREWLQIKMIFHSYGIFRILVKYAIPYVLDLKDKTAVIDKRLSFYLTLLLLNIFIFDVIYKCYKYVTEQDAVASDKEILPESDLDKISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHD3</accession>
    <name>A0A914YHD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHD3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18202.t1">
        <property type="protein sequence ID" value="PSU_v2.g18202.t1"/>
        <property type="gene ID" value="PSU_v2.g18202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18202.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33448" checksum="A7F5E6D9C3DCE556" modified="2023-02-22" version="1">MSSPTTPSSPPPTTPPSSPVTGVTTTTTTSAPPRPPKIPPPPNLDPPPYTPFSEHSAPLLPSSSSGVARPAAPIQGRHTSSSSGPRVVRPPGFRRYTQHCTKRNCILFLALLGILIMGILAVNYWLDSSEEDAAQINPLTFNSRNLAKFHIPDQRISYDENSDSVILSKFLKAQKQLKSEKLSIEEYDLGFLGATHDIDSDNYDDCMRFTDNVTDSVNAVILYNSQRHAILHVDANRLYQIQENKLPEKYKSVGFFFPMDTVDELDELVRSGEEFKICDYLLSSDTNTYILKEEECKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI67</accession>
    <name>A0A914YI67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17012.t1">
        <property type="protein sequence ID" value="PSU_v2.g17012.t1"/>
        <property type="gene ID" value="PSU_v2.g17012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17012.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18474" checksum="F638E5023B763B1A" modified="2023-02-22" version="1">MDLVSPYYSEMLFSGKRTFIWLCLPGLYWFYFWFIDLPCIYSSIASACFFDPFFGVSFPRNEWEYANWGLTFNNVAIILALSGMYIAIISALIAKTRMSTAATAIQRNTILQAFLICALCFIASAIYVSMQYLPTPPFVIILGQIFWQASHGKYLIKHTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIB0</accession>
    <name>A0A914YIB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18549.t1">
        <property type="protein sequence ID" value="PSU_v2.g18549.t1"/>
        <property type="gene ID" value="PSU_v2.g18549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18549.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="12608" checksum="DD5461E6EBD19F7D" modified="2023-02-22" version="1">MFIPAIVIGGQMAGAIGVTLVHPEFVAAVLSLAADTGGQLCAGPIAERATGAGDAAGGANSRGRAGVCGDDCAVAPSAGGGSEASVLSQRKNENAFTGGVNGYPRKVVRIFPLTLTLSPGGEGTDRAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM19</accession>
    <name>A0A914YM19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19963.t1">
        <property type="protein sequence ID" value="PSU_v2.g19963.t1"/>
        <property type="gene ID" value="PSU_v2.g19963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19963.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10764" checksum="2C2AA08F4637B869" modified="2023-02-22" version="1">MPLPAFGDTHLKREDVITAHPDIVRVDLSQRPLKYLIVASDGLFDVFENQEAIDFANQYLKVTGTSKWTKLAGAFCSEALARGSEDNVSVLIIKLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP23</accession>
    <name>A0A914YP23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP23"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20725.t1">
        <property type="protein sequence ID" value="PSU_v2.g20725.t1"/>
        <property type="gene ID" value="PSU_v2.g20725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20725.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8283" checksum="F961F308F65776ED" modified="2023-02-22" version="1">MSVTIVGQSLYDSQSRENYQILSVADINEMIIEVKYFFDLKIKSEQKVIMTGKIEEDDGLLVLVAEKGRIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQF3</accession>
    <name>A0A914YQF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQF3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19590.t1">
        <property type="protein sequence ID" value="PSU_v2.g19590.t1"/>
        <property type="gene ID" value="PSU_v2.g19590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19590.t1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38740" checksum="3A83BAD79B5D9C91" modified="2023-02-22" version="1">MLCPHLRYECGSTNVRFSVWRGMLELLQIFQDQKTNVRKLWERNLILGFMEFDQVSHLLEKYDSALIMRLSFVTGGTICFTVKSNAHSLQQGAMAPMHLEPLDLKKLQAKCLKDYLRDIAIAEKVQYIINADFEPVKITDIIDEFNESFGISEDIETSRRISSNVTHSGDIDNMQQITFTAMRIAVVTCKVKPPSADIDADNANLHAPKMTSPIPLGNGNPMMPKDPIRLASSASQNDEFLRELFQLCTFYGKTKQEVIEMVEQTPTFNLNQYSPPQSFMKSFESNGMLSQPPSTNPTPPSSAGYSSFGMMPPSQYGMHRGPNSNGYNSDGTEPMQYQPCYTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR17</accession>
    <name>A0A914YR17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YR17"/>
    <dbReference type="WBParaSite" id="PSU_v2.g246.t1">
        <property type="protein sequence ID" value="PSU_v2.g246.t1"/>
        <property type="gene ID" value="PSU_v2.g246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g246.t1"/>
        </source>
    </evidence>
    <sequence length="662" mass="76025" checksum="13EBA14A3C4BDB1B" modified="2023-02-22" version="1">MAFWDDFEDESVSLVKKLENESVSLQTIVDDPMCLMLIRDENTKIIDYFSQSATFRQLFYVALNTDIDNTMNDTEQYQFAYQCCEVLCFQQNKLYNAYLDDEEVLEFLTNFLEKQKEKMNHLIASFYARILLSLYNFDHTKVLEALSKTHFLDTALQLLKFSAISELLYNLTTCIPLESRDGVKKYFIEKDFGKKLCNSFKSTNDFIAMENTGQLWAEFIKNMRDFCYNYNRDDELLQHLENPELILELLNFMFPEDKSKRDSSAIVSGCLVLMAVLDRPHDIGQPSIDLNKTEERPKVFIPDTDFGCEALCAKYIAQLLDATLEAAKNHDGDVLARSMIVLEGIFNTSQTKNHIEFVEQLKTANFAQFFDFIKANPTISLLNNSIHTIVSYMLHCALSEEDHLVSYLFNDLGITSIILDALKSIPEDTSNVAVFGARAFFYRLAERIAIAKEQSQNNARITKRISDLADDKAWITFADGALMDYLHEHSPVDLSQTRNHSMSDISSRLDISVDEVVDIGVNELEPTLKTENVRSPTSSMIETLEKLDSNKPDNLFERYRAEMQKDNEEEDLFDLLNRPSTKVATMDVDDWPTSSAEKPNDSVDDELELFKKLKPVTSQPLATDQDWPVTTLPPPLKDQKEDDWNDFNAFSDDFPKKEKDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRL6</accession>
    <name>A0A914YRL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20032.t1">
        <property type="protein sequence ID" value="PSU_v2.g20032.t1"/>
        <property type="gene ID" value="PSU_v2.g20032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20032.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24846" checksum="46728DE668D82E9F" modified="2023-02-22" version="1">MPIDNSDGDWMPEIQRNMPKNKSLVVTTSLYANNINQNMLSMFIKNKFYQCEAKYIEIDRQKLTEKEFDFLVGRGNVESCSLREVQILKDDGQSLLIEEIMAKMPKLTDFSSFFINVTNESLEKLQQLSFQNKLLNCQFQGVHNDTVTAQAFCDFIVKNYTPLSTFALCFARGVTTHLFIINLRISMQQLVNNQWKTAESKPKIIISPDESPVPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTB4</accession>
    <name>A0A914YTB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3402.t1">
        <property type="protein sequence ID" value="PSU_v2.g3402.t1"/>
        <property type="gene ID" value="PSU_v2.g3402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3402.t1"/>
        </source>
    </evidence>
    <sequence length="664" mass="77511" checksum="29E207963AFA5105" modified="2023-02-22" version="1">MSKNPSKSRPPPLLLDNVDYFDFFKRKYDGWVLDDFCKQWDEFDCKKINGIVHYNVLQVFKFMLEKRNNKIVATEKSRKAKDEKIDSLEREKSGAIKNLNKQNEENTKLKLRIQELEGLWARECRKSDNDEEIVKLKNEIKNLQKVIKSKEDKYQEIVEKKEGELENVIAEVQSLQERNEELEIDLIAANNSIQNYSQKCNAFQQEINRLKSEINALNQNAKKLEIQMQQSNNVQNQLQSDLCEAKDSIQQLQSESQKEINRIKSESNEAKKELEITQNQQINKLKNELEQLKTNFEWAEEELKEYKEECKSYKSTDESQILQIQQLQLALECSTDDGKKMQAELTAFRKGNYENIERKAALLNKLAKSAKDVQKEELCQLKSVNAEAKKEKSLQKENESLSKEIQKYQLDYKNIVNEKNELTIKMDELKAQLIDSKKRRNRLDKRAERQKELRDGQQQNGNGEESSKRARFEMQPPPFLNMPVLIRQPNVQGSSPPNLISPSAANTSLHSAQLLRTGSHRNVNEVQQSPPNLVNQLNEASQMPQQFHLNCPSSNSTMTSTNFPSCSSNTNNNIHQQQQPYHPNFLPQMMPPSQTMWAQYQQQLLCHEIYMRNCQQQQQQQQHIRPPFQAQMLRQPPPPQQQQQQPVPHQPPPPYQFPNNRVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTK8</accession>
    <name>A0A914YTK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3327.t1">
        <property type="protein sequence ID" value="PSU_v2.g3327.t1"/>
        <property type="gene ID" value="PSU_v2.g3327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3327.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31799" checksum="01ACE4BEE8004496" modified="2023-02-22" version="1">MEGIALYGVKEGGKLNDLKQFLHGINENQWNLVLNGLVCKDRQTATYADFFRVGECKEMEENIKRLQHYFCRYGLLGADDEINNESLWCNRNMKQLRRNALFKIACTLAYSYRFTIDGKTLPSILKESMEIKSETELIAPAGYIGVYHKATRYSDGLIRAPMTFVSPYIFAHFTHPFQKMEEVNGKIELCTGYYNSIGIDVADKQRFFAFRQNVASKFLEHVSCQRGSTLKHAYDLHVSQVLLDELRKNQCRFPVFHGRVSNDEEDLLAEVFFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUL8</accession>
    <name>A0A914YUL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUL8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g368.t1">
        <property type="protein sequence ID" value="PSU_v2.g368.t1"/>
        <property type="gene ID" value="PSU_v2.g368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g368.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21802" checksum="F6EC233AB8273DC4" modified="2023-02-22" version="1">MFDTIIPNVPYSFCFQFVNKEFFIYVNEDGDEYLVKEMKCFIASANIQRFGDHFQIVTIAKREELFKPENNFFVDDILTIEIRGILCLETPNLNLLNNLWKKDDKDFTFVVGKKTVKAHKFIIRQCSAVFAAAIDSNSNEVKIENFEYNTVEPAVALCYDMDHYYSNMTGFEIIKFASTFDMPLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUR9</accession>
    <name>A0A914YUR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUR9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21227.t1">
        <property type="protein sequence ID" value="PSU_v2.g21227.t1"/>
        <property type="gene ID" value="PSU_v2.g21227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21227.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="23463" checksum="8042085D71DE7DD0" modified="2023-02-22" version="1">MLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIERELNGYLEWILSAEEVILKEDRTTEEEKAAIMEARRRAATKKLKTATKQQSTETEEDFEEEDDDEDEEETEAYVEEGGTKRTRRTFYESLCKKVRHLRVHLRVMVKSQIFYWLVITLVFLNTACVASEHYGQPEWFTHFLSMLFKKLILPKIDFTIFKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV14</accession>
    <name>A0A914YV14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4445.t1">
        <property type="protein sequence ID" value="PSU_v2.g4445.t1"/>
        <property type="gene ID" value="PSU_v2.g4445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4445.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20612" checksum="0070F749D166A783" modified="2023-02-22" version="1">MKTLLEINFLRVIVGTIRHLANDANNYVFHNKMSDDLLLEATEGEEQIIVDDLDVKLPNDHLLGIEEGDLINSEVKEEVNDLSKIKNMLLIFEETVSITYGQPHSLVADGLVNFCMDNIHSGNDTFLQTHRLAGDDLKSACHKFRGVQAGCARITDAYGLNNNFKPLRHHSWHYSYGKYKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVM3</accession>
    <name>A0A914YVM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methionyl/Leucyl tRNA synthetase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21564.t1">
        <property type="protein sequence ID" value="PSU_v2.g21564.t1"/>
        <property type="gene ID" value="PSU_v2.g21564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21564.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23556" checksum="7BDA12362D29AE5E" modified="2023-02-22" version="1">MLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGLSQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVU9</accession>
    <name>A0A914YVU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVU9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g411.t1">
        <property type="protein sequence ID" value="PSU_v2.g411.t1"/>
        <property type="gene ID" value="PSU_v2.g411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g411.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17934" checksum="CD2C4983F38B9FC9" modified="2023-02-22" version="1">MSESSDFKCRNHAETNPKFEMKSGNEAGTSEAHGNASTFQYPDGQKPVSQPIRAKSKKGRDPLHSVRHGRIERPRQFGMVPKVYTEKKGCGINGARVNAETSNLPAPRRISDPSENAAEDPCPFYPQSQKHFLKQKELEKRAAEDQDPYFYSPSQKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWH7</accession>
    <name>A0A914YWH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWH7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2436.t1">
        <property type="protein sequence ID" value="PSU_v2.g2436.t1"/>
        <property type="gene ID" value="PSU_v2.g2436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2436.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12679" checksum="6F933C9878B22E35" modified="2023-02-22" version="1">MYRLSHSVDRLPVHLENEQTVYMGENPDEKEMDNAKNKDSKLMAFFKVNQEREKEIEKIKAMIEELKAQGKPVNHIKIPEKFLYNKIGVTHVWDGKIEQIVFTLEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWJ3</accession>
    <name>A0A914YWJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWJ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4024.t1">
        <property type="protein sequence ID" value="PSU_v2.g4024.t1"/>
        <property type="gene ID" value="PSU_v2.g4024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036927344" evidence="2">
        <location>
            <begin position="20"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4024.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="43783" checksum="8A4F71843705D90A" modified="2023-02-22" version="1">MLKFCIGFVFILIIFGADAGVTTVQPDQPLGLSDKELSDFLNALAESKKCSLSIKDIKLRLPPSCGCCQMCSNSCSSNVDCNDNNNQSCDDDDNCNCCCCQDIPTTTVAPTTTTTTPQTPIPTTQCCCKPCCNKCKCKNQRQQSCGCRSNNGNTNGCGNSGTPPIGCGTNTNPGPVGPAYVLPPLIPQPQPPVYVFPPSSPQGPNSYPQAPQPFLPQPPPQPISPSAPNSYIQPPPPPPPAPAPGPNNYAQSPGTIVPPSYPMPPPLPIQNQSYPIPPPQPQIGYPIIPPSDNYPSPPLPNPGCIFPNPTQPCQNPQPQLPPFSYPIPPSSSSTTTTTTSTTTTTTPSSLQDDTISSFKNFLENQKMSDSILDLQPKSRDTVSNHPKSLSPENSSTSTGCLSAFAIIIIALCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX08</accession>
    <name>A0A914YX08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g464.t1">
        <property type="protein sequence ID" value="PSU_v2.g464.t1"/>
        <property type="gene ID" value="PSU_v2.g464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g464.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15369" checksum="83DFA2634FC2E8FA" modified="2023-02-22" version="1">MFELRFVPRMKELPTPEYVSQYLAHLGIHPKILDAVIFDAYCAAGCNPKNEWTSSIKDLEDPFTAHYFSEFAAAPPSSNFTPPDSMPLQHHEKSIDHFQPQWSGVSSSSAEEHSSLDSSNDYTLFGETYPSAFRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXJ0</accession>
    <name>A0A914YXJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXJ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4822.t1">
        <property type="protein sequence ID" value="PSU_v2.g4822.t1"/>
        <property type="gene ID" value="PSU_v2.g4822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4822.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16861" checksum="462A5EF6C24589B9" modified="2023-02-22" version="1">MLVIALSIVIAVSLMTTVILGTRLMRKAYEKRFAKNVKRHIDVLPRKKEPEPFPTESNILSFTLLERFYAAHPPQLSLPYKMAQTDAYVKSLPSLSFTPLPPLYEEIDLSSPTKIIVSISPPPSYPPSSPSSPPSSKIGENNENGKIVTQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXL9</accession>
    <name>A0A914YXL9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXL9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5251.t1">
        <property type="protein sequence ID" value="PSU_v2.g5251.t1"/>
        <property type="gene ID" value="PSU_v2.g5251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000005">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="1077"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5251.t1"/>
        </source>
    </evidence>
    <sequence length="1126" mass="127363" checksum="81BA2B072CA95B07" modified="2023-02-22" version="1">MKKSQPSKSPKTTPKTPSNQSSLFSFFKKVEPTSSTSLPKQAEKPTAQVSPNENIPLDRKRSVVEIEDESPPVTKTQTKRRRIVIESSDEEIEAMETSPAKPSPLTPSKVEGTPKTPSSGRHRIILKEEDSSFEFQDEPSPEKKKKPATPRTPAASRKKIGSLVKPNSEVTPSKSKTKPSEPATPHTPGAVKEAYESFRVDAEMDPQLISDKTSKKKQKIEDFVDKERWLHESFEFLQPENIRDINKRRPDHPEYDPKTLYIPKEHMDKQTPGHQQWWKMKSLYFDTILFFKVGKFYELYHMDALVGINNLDLTAMRGNYCHCGFPEIAYGKYSDMLVARGYKVARIEQTETPEMRDSRNKGAGSKDKVVKREICRVTTSSTKTYGVYDGTDDKNFIHTVEASASYLMALVEEQTSPKTSLYGLCFIDTSVGKFILTQFEDDSCRSVLRTVAAQFQPSHVIYPKGSVSSGTQAVFNSALSAVKKEALFNKKEFYPEDTVVTKLMNPEYLGNDLDKWPKELDTIFDMNLHVPRSLPDKKLCVRALGGLMFYLNRCLIDVDMFSMGQFEEYHPPSLSKDENRPQISGIERWKGKNLVLDGATLLNLHLVPPFTGKKAAAGLRDTTSLKFSLFNTIDSCKTPFGKRLLRSWICSPSCDPTVIAERQDAVEYLMQQDVSPLIKKMEEYLKKFPDLERLLQKINTLGLKYRSETHPDSRAQMFFPEKYNKRKINDLITTLNGFERIVKLAFAYSKLDIEKCSLIERCIGEEFTDIREDLAHFEKAFDREKAADDGQIVPRRGIDKDYDASLKKVAACEAACKEYLHKVQKEQKIPQITLHGTGKTRYLLEVPENMSKKLGDEFEYKSKRKGFGRYGTKVLERLVVDLNEAEKERDIISADATRKVFADFSTRKNKWNKVVSQIAILDCLASLAAYANTCKDLGFPMTRPQFDFESDMPHIEIDKGYHPLLISGNAKLAKSASKFIPNDTVFGKIKEDCQEPLVILLTGPNMSGKTTLMRQTAVLMVLGQMGGLVPAKFMKLTPADRIFSRIGAHDSSFAGQSTFYVELNETNSIIKNATKDSFVVIDELGRGTSTNDGTAIAGAVLRELADNLQCRTFFSTHYFALSLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYI2</accession>
    <name>A0A914YYI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5159.t1">
        <property type="protein sequence ID" value="PSU_v2.g5159.t1"/>
        <property type="gene ID" value="PSU_v2.g5159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5159.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="11006" checksum="FF68A4C34EDBAED3" modified="2023-02-22" version="1">MYKYCQDDLKQRLDEGYLEREIFRDFVLFHSKENKKLLRAALKAHHADFSYWNKVLNNEEAWNAEFGVDEHYRIPCVEFSKLRFNVLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZI4</accession>
    <name>A0A914YZI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lin-52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3447.t1">
        <property type="protein sequence ID" value="PSU_v2.g3447.t1"/>
        <property type="gene ID" value="PSU_v2.g3447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070176">
        <property type="term" value="C:DRM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018737">
        <property type="entry name" value="DREAM_LIN52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489">
        <property type="entry name" value="LIN52 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489:SF2">
        <property type="entry name" value="PROTEIN LIN-52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10044">
        <property type="entry name" value="LIN52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3447.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21165" checksum="362C4996DD691F9B" modified="2023-02-22" version="1">MHPSQNQQHLVYEEYYSTQDIEAPSMIPIQYSQQQQQTRYVSVPHLVQSHQPSSVPSQHIVSQQSQSSNNQIATTQSQQPSNSAEPIDLECEENLGRCKSPDEFPEYVPGAWDEVRQHKSIAPGKSAMRFRTELDSGDVKLVNELGQLTVDNLLDYMKNLQNNAFLLGEEEAKEFQRAKCLGIFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0U7</accession>
    <name>A0A914Z0U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P53 and DNA damage-regulated protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0U7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5983.t1">
        <property type="protein sequence ID" value="PSU_v2.g5983.t1"/>
        <property type="gene ID" value="PSU_v2.g5983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030482">
        <property type="entry name" value="PDRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162:SF0">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5983.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15879" checksum="7194C9B9E5C5BC35" modified="2023-02-22" version="1">MSEPSAMDLTAKMKQLEFLGHEVLSAKKRLIDLGSQKNWYREAWRAVQKQNEAPNGQKKTYIFISPRVFVQERTEKAVTLMKEDLDETEKEIEEMREELKKNVDELRKFEGKKDLTELGFNLKPVVSRFIDDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z225</accession>
    <name>A0A914Z225_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z225"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6416.t1">
        <property type="protein sequence ID" value="PSU_v2.g6416.t1"/>
        <property type="gene ID" value="PSU_v2.g6416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057411">
        <property type="entry name" value="TPR_IFT122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056838">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23377">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25295">
        <property type="entry name" value="TPR_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25144">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="9">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="9">
        <location>
            <begin position="183"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="8">
        <location>
            <begin position="301"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 122 homolog TPR" evidence="11">
        <location>
            <begin position="566"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 zinc ribbon" evidence="10">
        <location>
            <begin position="991"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6416.t1"/>
        </source>
    </evidence>
    <sequence length="1156" mass="131992" checksum="C6B4A6411B78CC3D" modified="2023-02-22" version="1">MTCFLSCIYDIAFKPDGSQVILAVDNRVMAYDPTDGVIITNSKAHKEAVFALDYAPTGERYASGSQDKQVIIWSDQHEGLLKYAHGDAIQCIAFSPISITLLSCAMSDFGMWSQAEKNVSKQKVLTRCICCSWNTDGSKYAIGMYDGTVIIRSVVGSNTVIGDEINKIERPAGEPICSVRFGSPRQLSNKLVDEILAVGDWAQTIGFYSNTGNPINKPDKKLSFVPTAMEYMIFHDGQFLVLGGSNRQVSLHTRDGTDLGLIAQLDAWCWKVKQRPKTAYVVSGCIDGTLSCHQVFFSTVHALHREFYAYRDQMTDVIVQNLSSSQKAKVRCGDLVRKVAIYNQRVAVQLTDKVLIYRQSSGERENEELEYKLMDRINQSFECSLLVVCSHHLILCHERRLLCYDYKGLKQREWLVDSLIRYIRVIGGPPGREELLVGMKSGMVAKIFVDNPFPMIMCSLSSAIRCVDMSASKRKMVTIEEMGQCIAIDTRTKEVLWVERANNSAVFNMDNEDLACFSSSGGTLGVKARNFPLSMQRIQGFVVGFFGKNVHALHMYIMNTVEVALTNHLFQYLEKKMYKDAYALATLGVTESDWKAFGLQALEDLELVIAKKCFQKIGDSKMLILISEIEQMIERGEPKEMQLAHILACNGRFREAAALFQDNGYEQRCLDMFSDLRMFDQAQELLSKASSETQRALLRKKADWAENSNDVRMAAEMLMASGDYDKAIILMINNDWLDMIVNALRKMDKSDVETLRKIGAYLVKKQEYTLASKLFLSLNDYKGILQMHITAEHWEDAFVLARRYPHLAKDVYLPYARWLAERDRFEEAQKAYHEAGMEEEAFRVLTQLTSNAVNENRFKDASYYNWLLGMQYLQRASEEPKMIPRFEEAFRKANAYYAYDAVYRFMNEPFTDKSQDTLFNMARFLAFVKPVEKMSRVNVLYTIAKIGRSHGAYQSARQALEQMRNLIIPYQYQNLVDVASLEIRATPFSDSEELTPVCYRCGANNPIMGGNECIHCESEFVYSFSTFEVLPLIEFGINEKITDEEAVNMIEAEPPVNSSYSNPFRSKGNWMNLNEQQLINLDRNQVFFSKFPPPLRYRFYYNMITEINLSKCSVCNKFYQMDEFEMALLQYGHCPFCRTPQTKSGDISDDENDLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z271</accession>
    <name>A0A914Z271_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z271"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6460.t1">
        <property type="protein sequence ID" value="PSU_v2.g6460.t1"/>
        <property type="gene ID" value="PSU_v2.g6460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6460.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30560" checksum="44FFF51D3D8B9B0A" modified="2023-02-22" version="1">MRSHLDLLREEYSQLQAKHVDLQRRYDLLAASKRLTSESEEISNKNDDDSASNFVQRLVAVVSQLYEKDLYSDITIHVDGRQLRAHKLIIYSRTNYWGDLHDVDNLDLGDMNYGTADIILRWMYSDTFDTKYGDSIVLDVFSYAILYQLSALKERCENILIGRLDIDNCVKIYQFAEKENLERLRDECAELVAARWNDFTAQHFADMDAALLYKMLKRRSKHVLSSIIKLQREDALFLYFVENDVRLAELTNEPDDDQNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2C2</accession>
    <name>A0A914Z2C2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antifreeze protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2C2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6221.t1">
        <property type="protein sequence ID" value="PSU_v2.g6221.t1"/>
        <property type="gene ID" value="PSU_v2.g6221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037777928" evidence="1">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6221.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9018" checksum="B427D33AD5CB28E4" modified="2023-02-22" version="1">MFASKSSTTLLIISLILLSIYTLKANANACSNVKAESEKARINAAAACSKAAKIAINSADSTKAVAKKACDDAKNIAKNVADKAAAAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z301</accession>
    <name>A0A914Z301_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z301"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6269.t1">
        <property type="protein sequence ID" value="PSU_v2.g6269.t1"/>
        <property type="gene ID" value="PSU_v2.g6269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6269.t1"/>
        </source>
    </evidence>
    <sequence length="535" mass="58889" checksum="4D1B9E0A9C32DF5D" modified="2023-02-22" version="1">MAKVNEKYVLNSSSESEVDTSESEVDLSDDDMEGQKIKPEINGKTSSDNNSSVFLKSNNKLQATTSSSKTAAATNSKPQNIKFVETSSSSEDVSDSSEDEMVQMKSDIKNNINGKQSSTNIPKIIGVGSIPPKIAPKQPVSINKTSSEDESDSDETFSSDDDEITVPRQKQKVNNKAAVQNFSKLNIVKTDETSEDTSDTSDSESDKTSSSDEDDDDNDASDEEEDETDDSESVVVESKNAAQILKKPAPNTVTLPQSKTTLTKFNNDETDEDYTSTEESEDEVFVKKPLTTKPFQTDSDSDSDEDPDYSDNSSEDDNIPIKKNDQASSTKAIIPPKVTTNMAPPKPPPRVTIPFQNPFSSIRATSQIAPTTIKQQTRKTQQQPPLEDNLLLNALRQFSLNLNNPVERQKELARRAEEAFRRNELTFVCCVCMENFYRDANFAKCKKLNGEKIKVDHYICITCLRGTATPENAGIAPDGSGLKCPFPECPNILLMSEIRGMIDAGIESNLLELIGRMSFASADIGILVTYVFIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3K6</accession>
    <name>A0A914Z3K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3K6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6941.t1">
        <property type="protein sequence ID" value="PSU_v2.g6941.t1"/>
        <property type="gene ID" value="PSU_v2.g6941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6941.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29688" checksum="B92408137384EB42" modified="2023-02-22" version="1">MNFIKKLIPQTTPRPQNYHHYVCFGNAHVKFATFIIIVIRLCFTILSAYYFMTGHVFYRHTLDIIYDCIEVLVLIFLIIGYINEDSKWTWPYMAIEFTWLILVLIVYAISITAIIFPSRFSGWWTYQDKIVSDPSKIRKYAFRTCVESAIAVTLCAFEISILLACNRYFDDEKARKKDLRERPIILNQDGSEGGSHQSAIIDMEPVLNTTVSVDQQQRQQNRGFANPNFSLVDSDDENDHDHDWHSKDKKANILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z406</accession>
    <name>A0A914Z406_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z406"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6624.t1">
        <property type="protein sequence ID" value="PSU_v2.g6624.t1"/>
        <property type="gene ID" value="PSU_v2.g6624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6624.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23311" checksum="6B95A122692D76E6" modified="2023-02-22" version="1">MLKNNKILVIINDENYEAEEIIAHEGYISDKSDELYDIGLNDIMLIKLKEPLVFSENVSSICLLQNLTVPAMEVAAAAGFGVRFIRVINLNDTFQDEFLNSNETIFEGNDLLRETPLLIRDLEYCGILDITEENGSTLVCAGGANHGTTPGDSGGPLLVVRDHRWVQHGITAYGSVMPIAGDLLAVSDIGVYTKISAFCGWIAEKTSNEVTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z452</accession>
    <name>A0A914Z452_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="11">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:22650"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z452"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7479.t1">
        <property type="protein sequence ID" value="PSU_v2.g7479.t1"/>
        <property type="gene ID" value="PSU_v2.g7479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7479.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10360" checksum="5B4027538F522B29" modified="2023-02-22" version="1">MGYQLPFDRHDWIVDRCGQRDVRYIIDYYDGGAVDPKSKLFTVLDVRPAVTDWQNMWDRMVVSYWRFKSETLGFAPNLPIPPTEEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5E3</accession>
    <name>A0A914Z5E3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">eIF-4F 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5E3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7111.t1">
        <property type="protein sequence ID" value="PSU_v2.g7111.t1"/>
        <property type="gene ID" value="PSU_v2.g7111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000014">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7111.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25196" checksum="DFDD956497A3EFE7" modified="2023-02-22" version="1">MSFQSRSNESEEPKPLVKFEQFVPASPPGLNDNVLEYTYVLSYFVRPQGKFDPEDYAQYVQPVASFSSVEQFWHTYRHLKRPSDINEKVDFHLFKEGIKPVWEDTANRKGGKWILRLKKGLSSRLWENLVIAMIGEQFLVGEEICGAVCSIRNQEDILSLWNRTADNPLIINRVRDTLKRVLNLPSNAILEYKKHDDCLKDQSSYRHTNPDVSRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5V1</accession>
    <name>A0A914Z5V1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5V1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5624.t1">
        <property type="protein sequence ID" value="PSU_v2.g5624.t1"/>
        <property type="gene ID" value="PSU_v2.g5624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5624.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8517" checksum="014F77E76AAC20B7" modified="2023-02-22" version="1">MDGKLEFKFCSEGCRDQTVSVCYDAQNIDSSLQTGCPSNQCMFKAGVSKSQGSYFLWFFDRIFPKGFTSDICETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6D6</accession>
    <name>A0A914Z6D6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z6D6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7470.t1">
        <property type="protein sequence ID" value="PSU_v2.g7470.t1"/>
        <property type="gene ID" value="PSU_v2.g7470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="7"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="257"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="750"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7470.t1"/>
        </source>
    </evidence>
    <sequence length="934" mass="106960" checksum="FFEF559FEA8F332E" modified="2023-02-22" version="1">MQHTPLPPCKMMALNIITVACPKTNKPHIVLITVLRSAAYYLDRRTSTKWDQKITYIAPPPGATFPIQFQQDIEKRKAQIEKCPNEKSMLQKFLGAVKMYDPDVVLGHDIAAQMSILRERLEDNKLVTVNWSFMGRLKRKENLKHAPQNKHFRWSWTAGRLYLDSKAAAMELVHSQSYDLDELVAKVLTPIEPNAKRLPIDTEMISRVFYENGGKTEPVFNLIQWSFYDAFFSHEILAQLNAMQLFLQITQIVGGVLSRTLLGGRAERNEYLLLHAFFRDGFVAPDRVTFKQKTKQVKPDANVINKNGGEETQPQQQQPSSKKAQYTGGLVLEPKKGLYETFIVLLDFNSLYPSIIQEFNICFTTVKLEQTKEANESDLPPIPDSSIEAGILPKEIAKLVHTRRDIKNEMKRLNDKHCERYKQYDIRQLGLKLTANSMYGCLGFEGSRFCAKTLAAMITSKGREILESTRNLVESKGYSVIYGDTDSIMVNTNSINLAEAKQIGYTIKALINKSYKQLTLDIDGVYKRLLLLKKKKYAGLAIDLSNGLKVSKELKGLDIVRRDWSFLAREIGDKVVDIILQSNGRDEMVEEIRKTLSDVKEGIEQRTIPLEKFEILKKLTHRPEDYRDAKSQPHVLVALRLNQTRNANLRQNDIVKYIICDDGSGQAATQRAYARIEIETNSELKIDSSYYLAHQIHPVVSRLCEPIEEMDACQVAEALGLDGTHYRRRLIEQIDDDANDENSAPGIIFNFNACDGLPIQCPSCKHVDIHRSPILDDKRPSLAECSSCHYNLLSDPIKVELQIIDFLQKNCKKYSECKYVCDDVVCGFELDFPPVFKNEFGFPCTECSHGFFKPNYTLKRLFDQQNFVLKIVNFDEWESKEATKEQKEAINAYSKIVNYRFNSKDWTKRVSKFINENPYNCVDLSFVFAPMKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6E0</accession>
    <name>A0A914Z6E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7500.t1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43577" checksum="9C4C8404A2F83CFA" modified="2023-02-22" version="1">MEGSTGCSSSLQITAYMDCLNDDDEQKELVADRTNVINGEHYMEDTECSRKCSRLFINGKVFDDEKVGDGQLMDDYDSEANVAELSVGIYPPVCVSNGDGIYKPSDELYTVKEIVIGVITNDDLNAVKDANYLPLDDTQHQIEPTEVDESEGAVRSIRAQVQSFVNDAAEAFHKLKENVNVANDMLHRMNKPNQKIDENLVSELEDFLTDSPDWCLSVMDGKDKTIELFEREILDLREQQSQLLFEREELQRKLGRESSKTSVMSAGDQRKLKALGINNLSDLINRYRNLQGELEASKKRFIVEASLTRGESLSSVCSKTEWNQQLQPEVLKQGGLTSVIDNGNVTGVNVKACIPLPMPDKFQGKTRVELERYFRYFDEAVTSRVCP</sequence>
</entry>
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    <accession>A0A914Z6E7</accession>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5814.t1"/>
        </source>
    </evidence>
    <sequence length="529" mass="59802" checksum="EB6AF8FD3261138E" modified="2023-02-22" version="1">MTPIQKCKVFDSRFVPHRNIWLKGDEDAAFECIDRTNYSSVVVRLQRFSTTDMERRKKGIQKAVGSAIKHSSLCDLKEVLVDEENRIIISISENARGINFQRFVELCSNKEGYDESLQHILLTLLQLYRDLHASDLDLSSLSLTHVVISLKNNSVSNVESVKVRRPFLCKFDQNRASTLPYSRFEAYPAFTDLAAAAFFSFQKEDLFGYSSILSALASLPSSQKCFFELLLAFQQHEFDAVCDIIKNMYNVEALEQPEPSLQEEVVEKAADLDDDFHSSDESESDVSEDDEKYEVSTANESETETALDEEEDDLKTAIGTEVDEDLMTAIGDDEELNTAIDVEEFEINTAIDEEEDEVKTAIEDEYDETRTAIEEDMEEVKTAIAHNFDIVDKMLVNVDALSLLPITPEVDDMFDARSLISNESDFDVILSADVVDEPQIVFTTKDYGFDGLIIKLFDNECVCCELNDQFVTFGSDMIEIGSSDSRDGHLLATDILQKLVSNVRVMYALTDATVPKKNYLVTFVEEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z875</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Panagrolaimus</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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        <location>
            <begin position="21"/>
            <end position="49"/>
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            <begin position="105"/>
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            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
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            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6453.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="29017" checksum="45E9A6AED761C6C7" modified="2023-02-22" version="1">MNLSYFPFMIAMLKKEFFQYSAYKFMFMMGFYDLFILPCNAIIAGIQVIQGRHFCNNPKLYYWSGVISCGGFYGVTTLCVVLAFDRFLEMSFPRIAPYIFGGAKTYLWMCVPIIYQCYIGFQLPHIFNIKIYAMNQDPFHLIPGMENNPKFHFDSFKVFHTWNNGLLIFFLVFFYGGLIVVAKLKSKIYNKPKISKIQKQMTIQALCVCGEMFFAPLIHIFMNIVEFPIIIEIIAHFSWICLHGKYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z884</accession>
    <name>A0A914Z884_9BILA</name>
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        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
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            <begin position="11"/>
            <end position="34"/>
        </location>
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            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8073.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16793" checksum="5C6603767CF7AF64" modified="2023-02-22" version="1">MKLLRNREKQLQCALCNESVKNVESNVRTHIASHADTSMSCLICKLCCFSSGDLHQMFQHMGSAHPSNRTCYEDRRNMTQLSELLSTCFPRGGVTKQRSGFIDSIQKVINVAKKRNETYINCAVCQKDIQATKEVLTRHMSSHHVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9W1</accession>
    <name>A0A914Z9W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="11">G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A914Z9W1"/>
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        <property type="protein sequence ID" value="PSU_v2.g9105.t1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="metabotropic glutamate receptor 1"/>
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        <property type="entry name" value="Probable metabotropic glutamate receptor mgl-1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
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        <property type="entry name" value="mGluR"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="547"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="588"/>
            <end position="615"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
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            <begin position="548"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9105.t1"/>
        </source>
    </evidence>
    <sequence length="646" mass="74336" checksum="B23E4312C78AA63E" modified="2023-02-22" version="1">MLYALDMINAQTDFLRGYKLGALILDSCSNPAYALNQSLDFVRDMIGSTDVSEYQCHDGKPPEVNYSPKKNVVAVVGASYSSVTVQIANLLRLFRIVQVSPASTNADLSDKSRFEYFARTVPSDNYQARAMIDIARKFNWTYISLVYSADEYGELGADAFKKEARRVNICIAIEERISIKREALTESVDNLVKKLQPDKKVGARVVVLFVGTEYIPDLMERTSERMKQEPNRRKNKRIIWLASEGWDRNNDAYTVGTRRLSAEGAIVLMLESQRVPSFEEYYLSLHPGNDKFERNKWLRELWEHKFSCEFNLPEGTSKNKCEPIRQSKENFSPDDKVQFVIEAVYAIAHALQAMKNHVCPNDTIETSWITRYAKLPEICTAMRHIDGDEFYKKYLLNVKFKDLVGKYVHFSPQGDGPAHYTILNYQPSANKQQTSDSDRGDYVEVGSWSEQRLEIKEELMFWNIDDDEEKELPISKCSMPCPLGYRKQLIKSDEICCWACGKCEDYEYLSNDTTCVDCGQGMWPTKDRRGCYNLTAEKLKHMKWSSWYSIVPSIFAIFGILATLLVIIVYIIYNETPVVKASGRELSYILLFSMIMCYTMTFVLVSPPTTFICALKRTGMLKKILKHLQAYFKMIIIHNYLNVCQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA89</accession>
    <name>A0A914ZA89_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Enoyl-[acyl-carrier-protein] reductase, mitochondrial</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">2-enoyl thioester reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZA89"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8839.t1">
        <property type="protein sequence ID" value="PSU_v2.g8839.t1"/>
        <property type="gene ID" value="PSU_v2.g8839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF1">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="14">
        <location>
            <begin position="26"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8839.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38901" checksum="4532D0AB248B1ACB" modified="2023-02-22" version="1">MQLLYFSARRMSTLISRALTITKLGDPRKVLELQKTHVSTKLAEKEVLIKWLASPINPLDINKIEGAYPGSESPKIGGSEAVGVVEKAGASSTFQPGDSVIPIGMGGDLWSEYDVVEDENLIKIRSNIDLISAATLLINPPTAYVMLKHFVDLNPGDYIIQNSANSGVGRAVIEIANAWGYKSINLIRDRPNVDELKADLKKIGANFVFTEEEFRKENRKISSEFDIKLALNGVGGRSALAISAVLTPGGTIVTYGGMSKKPAEIPTSAFVFKGIRAFGVAVGKWMCIEENRPLVDQMFDELQDLIVQGKLHPPPVETHDLENFQDAIDRTLEGKNPKQVLLIHPDYKKFMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAA8</accession>
    <name>A0A914ZAA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">POU-specific atypical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAA8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8858.t1">
        <property type="protein sequence ID" value="PSU_v2.g8858.t1"/>
        <property type="gene ID" value="PSU_v2.g8858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040363">
        <property type="entry name" value="HMBOX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006899">
        <property type="entry name" value="HNF-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044869">
        <property type="entry name" value="HNF-1_POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14618:SF0">
        <property type="entry name" value="HOMEOBOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14618">
        <property type="entry name" value="HOMEODOX-CONTAINING PROTEIN 1 HMBOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04814">
        <property type="entry name" value="HNF-1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51936">
        <property type="entry name" value="POU_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POU-specific atypical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8858.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28168" checksum="C4CA5978AF35A822" modified="2023-02-22" version="1">MTFPSTAATIAAAANAIANNQDLSTQSLFGPYPSSMQHHQQQQQASSGLTTSTSSTPSTSSSSVSRPIRSQRTPMKEITTLDDPTELEDFMQQGEEGCINDMKQFITQFSLRQTTVAMMTGVSQPYISKLLNGNHKELSLRCRKNIYSWYLNCRRHPEKLASFLQDPSTRLETNGDGELIPQRRERYVFRPILIKILETFFVETPFPDYNKRAEIASACNSALQMDKKGIYFYLFPRSSTSTVTDSNTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAE6</accession>
    <name>A0A914ZAE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9296.t1">
        <property type="protein sequence ID" value="PSU_v2.g9296.t1"/>
        <property type="gene ID" value="PSU_v2.g9296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037641444" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9296.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9845" checksum="972D7365A9FA9268" modified="2023-02-22" version="1">MEYLKLFIFVAVLFFGILAQRFQRHVITSNDGSNDSFPDIPDELAADVSPGIQEGNDVRLIGYGEIDVELLNGKLEFEFCSVGCRDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAV9</accession>
    <name>A0A914ZAV9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1-phosphatidylinositol-5-phosphate 4-kinase</fullName>
            <ecNumber evidence="11">2.7.1.149</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
            <dbReference type="ChEBI" id="CHEBI:84968"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:55993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
            <dbReference type="ChEBI" id="CHEBI:84968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:55965"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12280"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57795"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.149"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:12281"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.149" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZAV9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7391.t1">
        <property type="protein sequence ID" value="PSU_v2.g7391.t1"/>
        <property type="gene ID" value="PSU_v2.g7391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016309">
        <property type="term" value="F:1-phosphatidylinositol-5-phosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17305">
        <property type="entry name" value="PIPKc_PIP5KII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 5-phosphate 4-kinase type-2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="14">
        <location>
            <begin position="29"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7391.t1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45636" checksum="9B5AE02086FA7BD3" modified="2023-02-22" version="1">MASKKKTPRSLGRIRRGKPLIPKWKVFRAKEPVVSVFMWGVNHTIGELMHVPPPGLLMPDDFKAYSKIKIDYHAFNKDNMPSHFKIKDYCPNVFRNIREQFGVDQSEYLTSLTSYEPEVDPSESSGASRLFVSFDRKFVIKVIDSEAVAEIHAILRQYHEYIVERHGKTLLPQFLGLYRVTVDSNETYLLVMRNIFGGKYGIHKKYDLKGSTVQRQASEKEKTKELPTLKDNDFLDDNYKLMLPSDAKEQLMSLLKSDTGFLTRLHLMDYSLLVGIHDVEQGRREEAETAPPHSSDPDSGEDIQTPPDSPVASVAAFKPVATDVNLDDEFFGIASSPESPKKIIYFVGLVDILTYYGVKKRTASAAKSVKYGAEAENISTVKPEQYARRLLEFVNRNVASAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBI8</accession>
    <name>A0A914ZBI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBI8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9111.t1">
        <property type="protein sequence ID" value="PSU_v2.g9111.t1"/>
        <property type="gene ID" value="PSU_v2.g9111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47148">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47148:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9111.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10138" checksum="C1FD534DFCF3D47D" modified="2023-02-22" version="1">MGVLKKVQTTTLLQIAAGTFLIGATALYFAQKKLQDRVRSLSHYKEAFKIIGNHDAVKKLLGPPIAIGRVNFADRQNNFVSEKDSQLFSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBP3</accession>
    <name>A0A914ZBP3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FRA10AC1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g9737.t1">
        <property type="protein sequence ID" value="PSU_v2.g9737.t1"/>
        <property type="gene ID" value="PSU_v2.g9737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF25">
        <property type="entry name" value="PROTEIN FRA10AC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9737.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="39781" checksum="0ABCADF92B2A2171" modified="2023-02-22" version="1">MLLGDGHLRKHETKATKHPLARLKKHYAGLNAFQRHKQMINNYFLYYPGAHEKLKARDTSKDKNDYDIIRENHKFLWNSDDITEAEKSWDAKLAKRYYDKLFKEYCIADLSFYEKNKVAMRWRIEKEVKSGKGQFICGEKHCEKDKGLESWEVNFTYKEHEERKNALVKLRLCPTCSAKLNYHSMKKRVSKEKKESRKRQKKTKEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEDEAETQEEKDKNESEISQKAREEAKIAEEASKVWSRDPFAEKTQEETMDEFLDDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBS3</accession>
    <name>A0A914ZBS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9193.t1">
        <property type="protein sequence ID" value="PSU_v2.g9193.t1"/>
        <property type="gene ID" value="PSU_v2.g9193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF55">
        <property type="entry name" value="POTASSIUM_CHLORIDE COTRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9193.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18225" checksum="602D52B91536F986" modified="2023-02-22" version="1">MMEGRQRRFSTIQQINPSTLKVINTDERLRSIPDIEDIEAVEHGRHSRKQSIPQILSSKLNNLALFRDDDEDVRAQGHGSAMIGGYTIPGPSERASSEKKKADLGVMLGVYLPTIQHILGVTMFIRLFWVVGMAGVWHTMLILMLCCTCVSFFFKKKNSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC87</accession>
    <name>A0A914ZC87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZC87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7862.t1">
        <property type="protein sequence ID" value="PSU_v2.g7862.t1"/>
        <property type="gene ID" value="PSU_v2.g7862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN SQUID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7862.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33012" checksum="C852077F41A73B33" modified="2023-02-22" version="1">MSMQDNQHQDNSNGSPNGENKDSLKGNEDRKIFVGGIAYDVTNEDLSSHFATFGEVVQAQVKFDRTTGRSRGFAFVEFGTAEGCKKALNQKEQSIKGKQVEVKAAKSRENKKVFVGGLPADYPEEELRSHFASYGKVEDVEWPYDKVTKSRRNFAFIVFEEEDSADRAAAIARQTFGTRECDVKKAVPQSKRFNQMTRTMGGMRGGFTNGIRGNAMAMQNPQGWIGQNWNQMGAMPYAAGAGAAWNDWYSNQANFYPQNSTGGANYASANGYDYSQAQTANRPQQAATGAAAARYPQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE84</accession>
    <name>A0A914ZE84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZE84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9968.t1">
        <property type="protein sequence ID" value="PSU_v2.g9968.t1"/>
        <property type="gene ID" value="PSU_v2.g9968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9968.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15144" checksum="84713A0003C345E6" modified="2023-02-22" version="1">MFASISQYFMATCFILLAWMPFKSQAIAQLLYTLAIIFSGVNCVGVLKGIALQAVQYSYFLLILSAFINNGIVLILPFIKSVIVPNDTPHEWSIIFYAIGISLAVCVTIFNITCETEPRSWTYLSTDNESATNIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEY8</accession>
    <name>A0A914ZEY8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZEY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8847.t1">
        <property type="protein sequence ID" value="PSU_v2.g8847.t1"/>
        <property type="gene ID" value="PSU_v2.g8847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038165473" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8847.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25883" checksum="1AC519BF0B55A93E" modified="2023-02-22" version="1">MESMKVVFILLLLHLIQYLNASNIIKTEYGEIEGFKYLMKNGKNANIFLGIPYASPPIEDLRLEKPQPPKLWNSTLEAKKFGSRCSPHNAEIVQWFGAHSEDCLYLNIFAPEISETSKTHPVAVWIHGGGFCFGDSEIYGYKQLAENFVSRGIIIVTLQYRLGPFGFFSLGDHNLPGNLGLWDQRQALLFLHKVLPAFGGDKERITVWGHSAGGTSASLLSASPHTRGFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFR3</accession>
    <name>A0A914ZFR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZFR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9117.t1">
        <property type="protein sequence ID" value="PSU_v2.g9117.t1"/>
        <property type="gene ID" value="PSU_v2.g9117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9117.t1"/>
        </source>
    </evidence>
    <sequence length="945" mass="103642" checksum="BFB69D71A1BD5695" modified="2023-02-22" version="1">MKGRKHRRKTDASASSLEDDVFLESDLETIQKQDSDETNTPPSFEPSIPTLAAPPSQHLHHLQKQQQQQIPQADAFSQLLAAALLRASTTSSSTETPSTSTSTITIEGGGVGGGKEGSPPSIVEREDGSKIEIFEGVVTYYNPEGQAVLRQEGFLGEPEKLLAEVAKIQQMLEMKEIPTVEAIQSGDSEAKDFKEQLQAILLEIGIKPREMMPELAGEIGIEPGDIEISGRVISGTEAAAGPIVLTPKEVLGFEAPPIIMLQSVPSIEAEAITIPLPQQHRLRAPFESLSRDARDNTTLLIPPKTEIIQTLGIPQTWPEENIVEVTLDIELIRRTRSEMSSLSATGANYASVSSAEELPIEELEDLIDYDDLFNELELGSEQDEIELFMDSVGIQTDLSYFDRISEGMLTDPEKFTFGVQTDLTALDEEKGPQILFEAFLPKQKTHSVQTAPMVTSEAVQTEAQREDKSVGGLVDYESTEMQTTETEVKDASSDPHIIQISTAIQGDSPIRMERQAVQVSIESVTHATDAFVMEAERKPLLSQSSMQTDEKVFTDSESQADAIDTSDSSTETDVIHENKSAIVDILLPKVTIDNISQTEIVAEAQQRTAAEVNIPKVIIENVSQTEIAGIKQINSAAEVDISKESSDIMSQTDSVSEIQQTAVAEVNIPKLTIDSISQTEMSTENQQQKIAVEVDMKKLTNDSVSQTNLISETQGKAIAEVNIPKETIDNMSQTDAISESQEKKAVDVLISKETIDSVSQTDLISESQEKTIAEVSQTDLSGDTQQKAYAQVEILPKVTIDNVSQTDSVTESQQKIAVDTSEIPKVTTDSVSQTETTTKMQAMSTIEIQIENTAIQSETSSFYPRGDSPIDDENIRYLIDKSTEQDYDLVMQDATTQSRIARDNFGQQHSPSVKNTSSQYDIEMQQGEEKVAQTGPYPRTRVRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSA3</accession>
    <name>A0A914XSA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10155.t1">
        <property type="protein sequence ID" value="PSU_v2.g10155.t1"/>
        <property type="gene ID" value="PSU_v2.g10155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10155.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45870" checksum="9ACE551D7FFDB9B2" modified="2023-02-22" version="1">MDNNGSEIRQGFLCPFCFRDLCDSNALYKHVEENHQETSSINNDAIDALKGAFGRAKQKILKIDFSTIAGTSQSREDLRETSPNYVYFEEENQTVGIHRSLKSIYVSDRDNCVNAVAVDTNNLIIRLDKLINDCPDEASRKDFEKETVPWTADNSSAYCSKFLPFMVAQKLTNPAFTATEISSFKKNSTALTKFSDSGVKRQTTKFLSSFGIEASKFGIEQPSNPEEQSLRVCLKCKKLLERRQEAMDQMSMPSVFVDMYEKLCQLITQVSNLSPSYKRMAASLKNGESMYTLEAAVQLRKKLGSLQHEIQSLSERIEKWGLQGDPLAPKPTPREIILRGNIRYSAIAALQETVLDMPEIPSKEEYQELKEKHKEKVRRQLEEEKEVNGIRSFSVISFESCIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTZ8</accession>
    <name>A0A914XTZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTZ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10447.t1">
        <property type="protein sequence ID" value="PSU_v2.g10447.t1"/>
        <property type="gene ID" value="PSU_v2.g10447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF55">
        <property type="entry name" value="SCAVENGER RECEPTOR (CD36 FAMILY) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10447.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40965" checksum="073907D92A09CF59" modified="2023-02-22" version="1">MSCDVCDYDAMLSIPNLPGLGAFQELTNPKYKVSEFVQQLYSIGIMLLGEYSFVQVKFGELIFDGYADALLSAAHSELVKDIALTFGVSYFNESTFIPIPVPDMKRLAFFYQYNNTNDEEYWIDTGKNDVNNLGKVLSWGNLTLLPESWYSTIQSRMINGSDSGTFQHPDMKESDRLQIFMSFLCRSLYMDFSHKVDIDGIPTFEFQSPSSVFDTTLEENVGMQYENFERINYVPNWPKCPPRNTTADCYNFTIDCRISDNFCHTCCNGSYVNGTYLIPPGLFPVKCYPGHVKQPPFVVFISAPHYAYSPKELVDTVIGLSPKLPEHIPFKYNHEPVCFISDEIHTLMKYFFRLLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU14</accession>
    <name>A0A914XU14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XU14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11449.t1">
        <property type="protein sequence ID" value="PSU_v2.g11449.t1"/>
        <property type="gene ID" value="PSU_v2.g11449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF24">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11449.t1"/>
        </source>
    </evidence>
    <sequence length="504" mass="55865" checksum="C43AC63892F028FC" modified="2023-02-22" version="1">MGKADDPDCFKDDFAQQRTKKPHFDLSLGMCGMKSLRSFDPRGMYYGITLVISFHPLFITKVDQAFHVKCFFEEANRGLTAELGVSMIPTTEVEARHGIPGCTYSIHRSSIDDLDSGRPPGAPIQFAKIGDRVLHQWHCDDQMFGVLINNCYVTDGVNKRAEVIDSRGCPVDPILITGIRYSEDLQRAYAESQVFKFADRPGIWFFCQIQMCMKKEGMCDGISPPACASTIGSTHSATSFGNNLIEDENENGAVETEESALFTQRPRKQSKKGGNRKPLASESSVDEEVEDYGGEDFNRRETYQTTKKSKTSHNKHDYDESEDFHASKSSSSSRSGGNKSNNKQRLPPGYGLSTNPDYDLHAKEPVTVFGPAINPDNESPQKILPFGTENQSIEKNNKRSEIISTEFETDDDLATVTVTSTVPSSSTASRSGSGLSESDNKAAKDIKKDYVDYDSDVTIPPNLTDLLANLPEDINADSLQKMFRDSVADRRALLQGFDMLINKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUE9</accession>
    <name>A0A914XUE9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XUE9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11577.t1">
        <property type="protein sequence ID" value="PSU_v2.g11577.t1"/>
        <property type="gene ID" value="PSU_v2.g11577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF566">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11577.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40066" checksum="E1F0A7CFE2ED42BD" modified="2023-02-22" version="1">MNRLNVITRSQLTNSKRILGTGAFGTVYAGFYKVKDAKGKDIQIPVAIKEIKMDSSSAWSTETEMIAEATIMASLDHEHLLRLVGICFVGGVKLITVLRPMGSLRDFLVTNLNCLGARDLILYCYQICSAMEYLTRHKIIHCDLAARNVLMRKNNHVEVTDFGLAKMLEGSNSAAAGSKVPFKWVPPECLIPRGEFSEASDVWAFGVTCWEIITYGATPYKEEYIQKGDEMYRFLQDGHRLKQPSNCGVHLHGTLISCWSETPASRPHFSDLKETFLKYCKVPTEYIQDRHITQRMDSYVGSEEQQRHQIQRLLSLTDSAMGEQIYTDQNGFQFVYNPINPTNLEDGRPMPVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUL4</accession>
    <name>A0A914XUL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1094.t1">
        <property type="protein sequence ID" value="PSU_v2.g1094.t1"/>
        <property type="gene ID" value="PSU_v2.g1094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1094.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11293" checksum="D535629505328644" modified="2023-02-22" version="1">MAVQAMVAQVMAVQVMDIHNPVMDMVITGIHNINGLHTLTIPLSMISSKDNLLGDGNIQCVHHGVLHENLIPLDIAMEEDMVVAAAMVDMVVVIEHFFNFANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUX3</accession>
    <name>A0A914XUX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10769.t1">
        <property type="protein sequence ID" value="PSU_v2.g10769.t1"/>
        <property type="gene ID" value="PSU_v2.g10769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10769.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12937" checksum="33E5704C63451A52" modified="2023-02-22" version="1">MALSEEQRKERLQDSEKLVFDLFDNMVKYEQQQLEEVKRKCSQYRKEFEGLRHEREAAVNSHQAPYNVHIEGEVHHITIVSSACQEAALHAHVKVTVCEVGHTEAKVTGRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUZ2</accession>
    <name>A0A914XUZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUZ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11758.t1">
        <property type="protein sequence ID" value="PSU_v2.g11758.t1"/>
        <property type="gene ID" value="PSU_v2.g11758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11758.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13229" checksum="D2448A2B55051F8E" modified="2023-02-22" version="1">MATKCSMNLLLNNDLYTPNYGSIEDKRFKPTEIFTATENLQSRAVGDIEELRKVCFIQELRKCLHEHQCGIRAHSQVFGQIYDINKGVMSQIYHTAAFYVKEKWQQFKDFLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVD3</accession>
    <name>A0A914XVD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LNS2/PITP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVD3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10932.t1">
        <property type="protein sequence ID" value="PSU_v2.g10932.t1"/>
        <property type="gene ID" value="PSU_v2.g10932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="1">
        <location>
            <begin position="60"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10932.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14488" checksum="0AA7CA5301230056" modified="2023-02-22" version="1">MKLGEYGLAVFPQNKLSDDDLQSFQLQYGSNIAKFSVTTKFQGTSWCSCQIYLFKYSDKIVISDIDGTITRSDVLGHIIPAIGGQWAHAGVAELYSKIMQNGYKIVYLSSRAIGQSHTTKSYLQSFGPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWA1</accession>
    <name>A0A914XWA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase alpha/delta/epsilon subunit B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWA1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12215.t1">
        <property type="protein sequence ID" value="PSU_v2.g12215.t1"/>
        <property type="gene ID" value="PSU_v2.g12215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12215.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19949" checksum="D6FEC580BA73786B" modified="2023-02-22" version="1">MMIFLLYYKETYNEEYGIAVDNWLLDRVGRDPNFQRQITPVTNPYCFKVMGVEIHGTSGQNVDSLKRVKRSGNETLYFLHAIIQCGHIFPTAPDYLDLLPYPCKDGKDPVALDQLPHIFFAANQKKFATELVDYGNNQKVRLIAIPKYVETEAMVVVNLRTLQTSQIIPHRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWA3</accession>
    <name>A0A914XWA3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XWA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10812.t1">
        <property type="protein sequence ID" value="PSU_v2.g10812.t1"/>
        <property type="gene ID" value="PSU_v2.g10812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="8">
        <location>
            <begin position="209"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10812.t1"/>
        </source>
    </evidence>
    <sequence length="467" mass="53722" checksum="E2B8A3FEFB4B5E4B" modified="2023-02-22" version="1">MAISLCSSCYTAISEHLQDTQESEEYYQCCLCFGLLDPSIYQKIIEKTKEEYAQNRFDGKNFVLAVNFPVSQLLRELFIQKIMDKTWNEMMMSPKSRLTYILMAKFRQDGFLRPSLTGDLTLTVTFENSEFVQRDTDFFMCHKPAGFLNAGNRKRKQIDEEEITGLLTKVKVQNLVEQLSLDIIKAFTFTSPTKSLDVTVEFQRDLLHIGGRYCKFSRSLPQSPWTPNHETPKILGNSVAEKVSQPMHEYFRCDSTKFIASGREDIDVRMLGQGRPFAIVLQNARKWVEMYSKETREKALKILKEKINAENKDIQVGDLAVVTQKETQLLNVGQEEKKKIYTALCYSHQKITEEMAKKLEAAMPVEINQLTPIRVLFRRPLLDRPRTIHAAKIQILDDHYFYLSVETQAGTYVKEFVHSDFGRTRPSVGTLLGFELTDGMSILELDVEGVDLEWPPCKKEVKAENGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYK2</accession>
    <name>A0A914XYK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Synaptic cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XYK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13025.t1">
        <property type="protein sequence ID" value="PSU_v2.g13025.t1"/>
        <property type="gene ID" value="PSU_v2.g13025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13025.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19165" checksum="2666050B85A7709E" modified="2023-02-22" version="1">MKAFPLILHVLIIVIILFIKFDYIYGNEDAKRLYDDLMVNYNRHRRPAISPNEPTTIKLKLRLSQIIDVHEIDQIMTCSVWLKQVWIDNKLAWNPKNYGGVSVLYVPYEMIWVPDLVLYNNADSNYNITISTKATLHYSGQVTWEPPAIFKSLCQIDVQWFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZW1</accession>
    <name>A0A914XZW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcyclin-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZW1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11172.t1">
        <property type="protein sequence ID" value="PSU_v2.g11172.t1"/>
        <property type="gene ID" value="PSU_v2.g11172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06468">
        <property type="entry name" value="p23_CacyBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037893">
        <property type="entry name" value="CS_CacyBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="65"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="143"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11172.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26068" checksum="4FC1B7D4233D5261" modified="2023-02-22" version="1">MASDLQKIIAEIDSLSAQATFPVVQQALKELKLKQQSLLDHAKFQEAASSVPSKPAHSSSNRPLTKLTTYAYDESDKFVKLYYTLNGVQSLPAENVKSCFTDDSFDVTVTDLDGKDYNISARGFVHPIDAENSVVKQKSDMLLVMLKKSKAGTWSELLKIVHSKKEAAKLKDADPAMDSSDPQAGLMSMMKKLYEEGDDETKRSLRKAWHESQNKQGGGGGLGGGFGGGDMPGMPDLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y057</accession>
    <name>A0A914Y057_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphoribosyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y057"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1126.t1">
        <property type="protein sequence ID" value="PSU_v2.g1126.t1"/>
        <property type="gene ID" value="PSU_v2.g1126"/>
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    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023747">
        <property type="entry name" value="Xanthine_Guanine_PRibTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006613">
        <property type="entry name" value="PRK09177.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39563">
        <property type="entry name" value="XANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39563:SF1">
        <property type="entry name" value="XANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1126.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12270" checksum="2361238180AB09B9" modified="2023-02-22" version="1">MIETVCIASYHDYSEQGELRVIKEIGEKLLVNGGEGVLVIDDLTDTGKTAQMVRKMMPKAHFATVYAKPQGRPLVDTFVTEVSQDTWIYFPWDMGFTYQEPINKSHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y094</accession>
    <name>A0A914Y094_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y094"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12883.t1">
        <property type="protein sequence ID" value="PSU_v2.g12883.t1"/>
        <property type="gene ID" value="PSU_v2.g12883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851:SF5">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12883.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22195" checksum="1F524909A35FA0E8" modified="2023-02-22" version="1">MFIYFRYHQTMSEPYFDRLHPKYKCCCGLTHVETGTKLICGLALAIYIISIILYFVNGPDPLVGRLELILDIIGALMVAAPIVGIKEAKPQYFLPYLCFLGFNVCAVAIQIPFFVFAYNQNSTVRTWIKNASPAMAHNETAINGIITYNLISCIVVFLLNAWFLEVIYKCYKYIKDKAAVGYNELTIPQLITSSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0D8</accession>
    <name>A0A914Y0D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y0D8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13669.t1">
        <property type="protein sequence ID" value="PSU_v2.g13669.t1"/>
        <property type="gene ID" value="PSU_v2.g13669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF139">
        <property type="entry name" value="SEMAPHORIN-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="2">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13669.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23272" checksum="803F31F229040BF6" modified="2023-02-22" version="1">MKPQIFHITSHKLDDKSHPRTMLGICSPQSGLNTTAIYVEDGNPDGIPSIYSGIRIGLTLENYLIYRPPLEFNNRQIHSALSTIYTDSKWLNEPQFVGSINSENYVYFFFREIAIEAESCGKVVYSRVARVCKKDLGGKNVLSQKWSSFVKARLNCSISSSQFPFYFDHIRKFYKVYSNHLKKPKSCCKQDMQIFCFNLIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0G1</accession>
    <name>A0A914Y0G1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0G1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12273.t1">
        <property type="protein sequence ID" value="PSU_v2.g12273.t1"/>
        <property type="gene ID" value="PSU_v2.g12273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036949412" evidence="1">
        <location>
            <begin position="19"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12273.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38584" checksum="CAD769BFFDB21FF1" modified="2023-02-22" version="1">MFFPVFSCYFALIHLTFAASIYQRCTQLSTKYNLLDSSNTSIVSFSANFDYIKLHSSAFNIVIIDNITSFADYHEIDVLLELDSYVDDVDTVCWLDAGCQLYVENSFLALFLNAQNGTDIQNFLVFKGLIDEKSFSLDDGFIFSKDQRCHIRNKNTLFGFENVTAKFQTCCTSFDPPFSLPTIIVPKCIEFQSRSTIYNTDDNYSIFATLKAEYSLTKDQLIIKTNYSGPDDSTYQLSANGLINCNGNNNYLSSAECEFPIKNFNTKILINIRMQKIEGSDSWEFDYNGGRLIIFENETLMSEGKPFTIENNCFYFSHNYSVPKVAQSQFCCSKFEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0P4</accession>
    <name>A0A914Y0P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0P4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13026.t1">
        <property type="protein sequence ID" value="PSU_v2.g13026.t1"/>
        <property type="gene ID" value="PSU_v2.g13026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13026.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11205" checksum="D53DF531012F94E5" modified="2023-02-22" version="1">MLDLYEYDEIKIVLSNSQRITLTCYIKKHEEDAIEVHIINPYNVKINGKKGDFKYETTDQKDINLPLIFIFDPSTVSEISEEYKAAYVSSRLDMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0S6</accession>
    <name>A0A914Y0S6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y0S6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13811.t1">
        <property type="protein sequence ID" value="PSU_v2.g13811.t1"/>
        <property type="gene ID" value="PSU_v2.g13811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13811.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29496" checksum="3437205DE7681DC8" modified="2023-02-22" version="1">MADLGDTMTFFERFKSILGHTVTPYAVRAMSADAETEIFRKYIDPNFPHLFEIAKTAPLIFVNTNELYDLPRPTLHKIINIGGIEKPSTVSKALPAEYEEKIEAAKNVVVFTFGSIANASKMPESWKNAFMGAFEKFPETQFFVRFDGSNLKPPKNVHLSKWLPQVDLLQHPKTKAFITHGGFNGLQEALVAAKPLLVVPLFGDQFKNARIAEKHGFGITVKKSEMSEEKVTAALKALLNDPKYSNAVKQMNAMIKKQPIWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0U9</accession>
    <name>A0A914Y0U9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0U9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13835.t1">
        <property type="protein sequence ID" value="PSU_v2.g13835.t1"/>
        <property type="gene ID" value="PSU_v2.g13835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036926928" evidence="1">
        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13835.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19349" checksum="1B22B50B34ACD73B" modified="2023-02-22" version="1">MHSFIFYISFSILATTVSYARLHNLGDSVDYNGKEKEGKLVLDCYEQITRKMAETYKSFTVYSESPEMCLIFLPENVEVSYTELNFTTPETYTRVLAGAAKKRVTYRYAPIFRSNSTEDYGIFNVQCPFGLIAFKSYDSVGKESIEFTLNATYEPAEWTITCPRLASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0X5</accession>
    <name>A0A914Y0X5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0X5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1386.t1">
        <property type="protein sequence ID" value="PSU_v2.g1386.t1"/>
        <property type="gene ID" value="PSU_v2.g1386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1386.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20977" checksum="3CF76BAC0E48277B" modified="2023-02-22" version="1">MHFCWKEEKPKKSRTRKCSIPVVEDAIPRISQEQQLYAPIELHCATESAVKAVDRTVNALEKLVLLAPKNSIEKHLMKTISLMCVFLRQFHTELRTRKDRRSKLEIILKLWTELQMQSSQGHPISIPSEVYQQPSATIIQRSTPPPPKMSAEELTVKMSMVSPSISTISNYFEIKKKKKSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y104</accession>
    <name>A0A914Y104_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y104"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13888.t1">
        <property type="protein sequence ID" value="PSU_v2.g13888.t1"/>
        <property type="gene ID" value="PSU_v2.g13888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13888.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17131" checksum="D58C79E098F6A9F6" modified="2023-02-22" version="1">MKLVEDNILVKLQNHNSFIFTTKSVMELEPRLRADNYDIPQCPVCSLLIIVQRFSYFCESCETAIHNTCLYKMINLSKNTAVSCPGGNRCSNKYDNDTLEDLEFDADLPETVNRPVEIRGNARTQQDDNTENEEPDDEDIDDEDMEVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y237</accession>
    <name>A0A914Y237_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y237"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11871.t1">
        <property type="protein sequence ID" value="PSU_v2.g11871.t1"/>
        <property type="gene ID" value="PSU_v2.g11871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11871.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="23196" checksum="FAF4CB1F98E3A4A2" modified="2023-02-22" version="1">MHENTKICLNQNRRYHSKCCIDIDLNKLTNKIWVKNQLILNQKNISTFSLIFPKLFRWNIIQLNALGTEIMFDDFKSCASFLTHTDFWRSRIINNDGSVVMLNKILEITPNIKNFEFSFYNDFSMINASTMKNICKLKNLQNLESFILIDIPEVVNVEDLSTFIKNHRNTKIEFHYIYRVSEAYKIQLEALIDSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2B5</accession>
    <name>A0A914Y2B5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2B5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11943.t1">
        <property type="protein sequence ID" value="PSU_v2.g11943.t1"/>
        <property type="gene ID" value="PSU_v2.g11943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11943.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12822" checksum="94C92F715A5C076F" modified="2023-02-22" version="1">MSMPGGDDFLNIRRSATGFSDYPDYRLSYENTITIDPTTGMRHSQTHTRPFLSARGVGEISPLAQQQHQHNQQPITYNIPRARNVSAGPSRQKFSVPDMPFSKLVNYFYDTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3W4</accession>
    <name>A0A914Y3W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3W4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14124.t1">
        <property type="protein sequence ID" value="PSU_v2.g14124.t1"/>
        <property type="gene ID" value="PSU_v2.g14124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14124.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10035" checksum="F4E73DBB09BDD8D4" modified="2023-02-22" version="1">MVKSSALGYSFIGLTAFATLIALIALFTPSWRSSGDYGLGAGGVGFNNNFGAAGAAGVGGFNNDYGIKFGIVTYSCGSYGNSFAYQNCYAQWAGRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y538</accession>
    <name>A0A914Y538_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y538"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1455.t1">
        <property type="protein sequence ID" value="PSU_v2.g1455.t1"/>
        <property type="gene ID" value="PSU_v2.g1455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990834">
        <property type="term" value="P:response to odorant"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF2">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038032934" evidence="1">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1455.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16290" checksum="6380ED220A583457" modified="2023-02-22" version="1">MRVAEFAVLLHILFISSIEAVHGATKCYSCMSRYYGLTWQFAGYSRIYMEPRAFTDNCPDPNKRNSEVPFVYCEDQSNCLTLVEDLQIGVGARGYIRGCWSSIFLWGFNRTGVVGSLRNEQFCHNFNLSQLLSGGKPFESKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6I8</accession>
    <name>A0A914Y6I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6I8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13266.t1">
        <property type="protein sequence ID" value="PSU_v2.g13266.t1"/>
        <property type="gene ID" value="PSU_v2.g13266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="461"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13266.t1"/>
        </source>
    </evidence>
    <sequence length="821" mass="94378" checksum="53AEC79C74A58209" modified="2023-02-22" version="1">MDNLLENCDDLKGMHDQFFKRLTTFESEKTSTQKVDSIVCDYLNNFESNDIPESIRKVLHNGEKPFKFPSKDKVAEVIKSEAEKLIRVELADLAQNDELLKMVNGYEDENVSFTFNKEEQKKLNYIQAEINFAIKAEMAVENPKILGMKDEEIEFIEPWNEEIIAKNSAIVNEFLNEVENVRANAEYPDLDLRETFVPPYEPKIDPLSFVHDLAAQNLFTIDVIPVLNEKAEVIGMTEVWGQPLDPNAVANSMKHGTSDTSGMHQMRGNGLEVPLGIISNNEIVKSHPSEDDHDEIRYVDHKVILEIDNTLPGRWPQIFENIRSKNVAETSEVPPPSAPAKFTDIFEMMNYITVIPESKVSTRATIYDAVNDLEDISAFKKKKKPKKIEEIIPAEILAQVQVFQSDEQKIDTTTKSKKDIDEFEFAEMLEIQSNVSEYHKMKNNLARTYPFELDPFQQQAIVAMENGHSVFLAAHTSAGKTVVAEYAIALSRKHRSRVVYTSPIKALSNQKFRDFRNHFEDVGLITGDIQLNSDASCLIMTTEILKSMLYNGRVSPDELEWVIFDEVHYVNDIERGHVWEEVLIMLPHQVKIVMLSATVPNCLEFADWVGRIKNRKIYVIQTLHRPVPLVHHLYSGKDARSQNDIFEIMGSDGEINYTSLRNFINAREGQWPESNNGVAQNPNDMYFSQNIDRCHYITLIHFLRNSNLLPAVAFIFSRERCNKYARMLHRIDLTTANEKAAVRKLFVKYLDSFQECDRNLPQIKQMQELCNRGFAIHHSGILPVLKELVEILFQRGYVKFLFATETFAIGVNVWFCILYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y860</accession>
    <name>A0A914Y860_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y860"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16382.t1">
        <property type="protein sequence ID" value="PSU_v2.g16382.t1"/>
        <property type="gene ID" value="PSU_v2.g16382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16382.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23016" checksum="5E037D0222A61335" modified="2023-02-22" version="1">MGEDVHEQRAVGLQPLADSRQQAFVVAHMLEHFHRDTAIKARGGQLELVDVAGQHLDVVQPPGLALRQDVLALAVRIGHRRDRSGGIALGHPQGQRTPAAAQLQDMLAIGQSGALAVQFQHGFLGLALAQAGLEEGRGNFVVLAVGRVGMQRERAVGQFCDATVEARGLCFDTAQQFLVHALRAQATDAGPQRRIGNQSALGPGDQPGFRVVGRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y896</accession>
    <name>A0A914Y896_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y896"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1642.t1">
        <property type="protein sequence ID" value="PSU_v2.g1642.t1"/>
        <property type="gene ID" value="PSU_v2.g1642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="91"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1642.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="25950" checksum="677A5702485C5858" modified="2023-02-22" version="1">MADQGNWFGQGEYQGWQQFDYSQSQTQPGSSVHNQGSFYGNTQATPQMFIPQHEIGKTAATDDYDYGNEPPLLEELGINFDHIRQKTFAVLNPVGTASAEVIADQDLAGPLVFCLLFGASLLLHGKLQFGYIYGIGLLGCVGMWCLLNLMAEEQRSISFTCTASVLGYCLLPMSILSMLAAVLSLNGIIGYGVAGAAAFWCGSTSSKLFSITLQMEGQRLLVAYPCMLLYCVFALLAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9Q7</accession>
    <name>A0A914Y9Q7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y9Q7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15496.t1">
        <property type="protein sequence ID" value="PSU_v2.g15496.t1"/>
        <property type="gene ID" value="PSU_v2.g15496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="99"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15496.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19034" checksum="62B76B7D55A35996" modified="2023-02-22" version="1">MDRPRPPNFSTSPFFNLSLFISPEMLHQRLRTTASQDILLGGGGGDRIDPSHPQHTNNIISRQHQSAPLPPIQRPNVKTILSGGIKEFVDKNSLSNPFFAAKRIMNDLAELEEKPLKGVFVGPANDHIHELLAVIEGPKDTVYEGGIFFVDVIIPQSFPFQPPKVCLKFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9R0</accession>
    <name>A0A914Y9R0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y9R0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16171.t1">
        <property type="protein sequence ID" value="PSU_v2.g16171.t1"/>
        <property type="gene ID" value="PSU_v2.g16171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16171.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="23792" checksum="6A9DEF055D5F7BA0" modified="2023-02-22" version="1">MAVGMSFNGLRPVCEFMTWNFALQSMDHIINSAAKTFYMSGGQINSPIVFRGPNGAAEGFAAQHTQDFSAWFASVPGLKVLSPYDAEDAKGLLKAAVRDDNPVVFLENELLYETSFPVSDAAIKDDFVLPIGKAKVQVEGSDVTIVSYSLGMKYSMEAQALLKKEGINAEVINLRSLRPFDFETVSKSVKKTGRLVTVETGWPFCGIGAEIGAQVFECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA16</accession>
    <name>A0A914YA16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA16"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16276.t1">
        <property type="protein sequence ID" value="PSU_v2.g16276.t1"/>
        <property type="gene ID" value="PSU_v2.g16276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16276.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21820" checksum="7D7F6206228DF955" modified="2023-02-22" version="1">MLEYSPKTGDLSYNKEGKKKGQHLKIISVKHDDEIVRISYMYDEIKSKIGLNFGNVCICLDEKYTNEIRAEFIEQGLNCGFKNIKIINSQTLLYLNAMSEIKYKPLNGNAIWIESEKNFYLWNLWKIVGKKAVYFGEFNGDSSRLVDLQKNGDQKSEFIDLPSYDEINLDFKIDENENLFGKFRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAI5</accession>
    <name>A0A914YAI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosomal protein S6 kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAI5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16294.t1">
        <property type="protein sequence ID" value="PSU_v2.g16294.t1"/>
        <property type="gene ID" value="PSU_v2.g16294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000121">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001170">
        <property type="entry name" value="Ribosomal protein S6 kinase alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="94"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="191"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16294.t1"/>
        </source>
    </evidence>
    <sequence length="473" mass="52754" checksum="4A562E61501F28CE" modified="2023-02-22" version="1">MAPEVVNRRGHSTAADWWSLGVLMYEMLTGHLPFQGENRRETMTQILKAKLRMPGFLSPEAQSLLRSLFKRNPQNRLGSGPEGIQQIKNHPFFVNIDWVRLFKREIPPPFKPAVNTSDETVYFDSEFTKKTPRDSPALPPSAAAHELFRGFSFVAPHMYEQMAKNEVKKAAKTSGVHGIPQAKRTRFADDYEIKEDIGVGSYSICKRCVHKVSRAEYAVKMIQKSKRDASEEIDVLLRHGHHPNIIRVYGVYEDEETVYVIMELCKGGELLDKILSKKNITEKEASTIMAKVVSVVGYLHQNQVVHRDLKPSNIMYLNSSSDTDGVRIIDFGFAKQLRAENGLLMTPCYTAQFVAPEVLKKQGYDMSCDIWSLGILLYTMVSGETPFAQGINDSPQQIIDRIGQGSFKLSGGNWDGISGMAKDLGALTSTYKALESANSPSPLCPVNASALAQRRKKERGSSQSESSMTAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBM6</accession>
    <name>A0A914YBM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16824.t1">
        <property type="protein sequence ID" value="PSU_v2.g16824.t1"/>
        <property type="gene ID" value="PSU_v2.g16824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16824.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="8988" checksum="6081E75682639EA0" modified="2023-02-22" version="1">MDELKMDSEKSPSKMSTLKSTTPSRTTSITTEHKEGGEEQAILHSSMKCRVVVPPIGHSNGGASDDDSEQAGKGSVKQSNNNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBU3</accession>
    <name>A0A914YBU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">IFT81 calponin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IFT81 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBU3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16891.t1">
        <property type="protein sequence ID" value="PSU_v2.g16891.t1"/>
        <property type="gene ID" value="PSU_v2.g16891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.70">
        <property type="entry name" value="Intraflagellar transport protein 81, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029600">
        <property type="entry name" value="IFT81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041146">
        <property type="entry name" value="IFT81_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043016">
        <property type="entry name" value="IFT81_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18383">
        <property type="entry name" value="IFT81_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT81 calponin homology" evidence="8">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="328"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16891.t1"/>
        </source>
    </evidence>
    <sequence length="501" mass="58991" checksum="FA5EDBEDE9290084" modified="2023-02-22" version="1">MHQRWRLEILEGEKSAIYPVLEWIFNNVDRLKERVYLARYLTRIEVPPEEVTPDIQRVQNGITDKMEEFKHIHSRIVESRSDFSRAEDIRADLKAMEEEKEQLQRKIDRVKRIAAGRGENINRNLEIAAKLRAEVERGEMLNVEKQTQRNALVHIEQRVHRLNRMKNELEKEKDNINPQSLIDKLKREIDTNSYIIEEKLAKDIEMMQKNIKSVNKILNLQNVTNNDIINFKKRIEALNNDIIQITTNRDKKDEEHEDKLSIYRHQSINIQRKKQAIAEKMQLAKRELDEMDIILGKFNFTSAGHGVIENLSAQNSRPKTAKPTTNNVNNLKTMAKDLNDRVSHKRDEVQKIKEEFEEFAHRHRAANEEYESKRSKYTIMKNELENEQHELEEDVKHLEAQNNKLIQEKTKAENELSDKEWLKESIDNPSRASEILQEINQKHSTTLSEIEQLRSKLTELSGKANGKEQIQMWKGLIAIFEKKIELTQKNSVEAPFGDSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD07</accession>
    <name>A0A914YD07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1718.t1">
        <property type="protein sequence ID" value="PSU_v2.g1718.t1"/>
        <property type="gene ID" value="PSU_v2.g1718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="236"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1718.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="34368" checksum="8C998B972237E31E" modified="2023-02-22" version="1">MREEKFKQIERPILWSLSYSPDQALIYKPSTSLGVTYTWNDKLQQDLYEIVLAFVDTAMKDLKQRELRLQLRKRCRRFGRQMAAAFRAMDIDQSLSWEMLGQSMLESFATSFRNNATKIFLWQLFLEHISAMVFEAFCWAVARDYTSTPLQTIYETDLKQCFPHLTTVERKTPILKKIIAKFTRFSKSVDGNNNSNTKKAQSPSPSKKANLDRSHQIQQHEQRRQNFSGPARMVPKNAETYRALYQYKPEHSDELELQENDIIFVVEKCDDGWFIGKHRFPTTEFFYRNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDJ6</accession>
    <name>A0A914YDJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal lipase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDJ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1737.t1">
        <property type="protein sequence ID" value="PSU_v2.g1737.t1"/>
        <property type="gene ID" value="PSU_v2.g1737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF5">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="102"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1737.t1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36207" checksum="52EA7C16F82A8522" modified="2023-02-22" version="1">MIGEKYFITTFFFVAVAFCCFGISNAAFDETYAKQMINFAAASFIAPQTVNNTVLAKQCFEKSFPNGQWEESEHSSIKPCAGYFNDECQLIITRSVPLNLVVIAFRGTVGEDQMKDETSASLKSYIPWKYDESVGHVNRYFFDASESLWGGKVEYYLKTYKTYKFAFTGHSLGGAIASLIAFKARQQRLVNNTSLYTFGEPRIGNKEFATNFRKYVPESYRIIHNSDLVPHMPLCAGALTSKCKDDSASPYHQPQEIWYNNDDLTMDNSKFTTCDPSDGEDPKCKAQICIYIIMIINWMNMDQRVAIPRSQLDYLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE15</accession>
    <name>A0A914YE15_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YE15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1566.t1">
        <property type="protein sequence ID" value="PSU_v2.g1566.t1"/>
        <property type="gene ID" value="PSU_v2.g1566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1566.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="13699" checksum="3C73A78AACACA8D1" modified="2023-02-22" version="1">MSGRGGKGAKAKTGGKSKSRSSRAGLQFPVGRLHRLLRKGHYAQRVGGGAPVYLAAVLEYLTAEVLELAGNAARDNKKTRINPRHLQLAVRNDEELNKLLSGVTIAQGGVLPNIHAVLLPKKTGGGAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE26</accession>
    <name>A0A914YE26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15669.t1">
        <property type="protein sequence ID" value="PSU_v2.g15669.t1"/>
        <property type="gene ID" value="PSU_v2.g15669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15669.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19941" checksum="99A2CA614E3D32C8" modified="2023-02-22" version="1">MNSQNSIAQLDPFQLPQESTTNKPNEYLSDSESDMENPISWFSNLPAANSMIELFADSVRNAVRDSTQFYFSPDLPPVAYPEVLQRPNNPAETAQRILVESDWIKRLKFIKYALPADEEIEFVTANIADLNNVHHKSGNPRSIRFVEKHLMYILARAIFCAAKLKNLLNSIGEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE58</accession>
    <name>A0A914YE58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18536.t1">
        <property type="protein sequence ID" value="PSU_v2.g18536.t1"/>
        <property type="gene ID" value="PSU_v2.g18536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037448019" evidence="1">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18536.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38085" checksum="3A3D1CFC1D0E6148" modified="2023-02-22" version="1">MLRYLSLWIFAATAIGLTISAKVPICNGLRYSGALIKCGTEKAFYSYGFDLSVSINPKNSTFPNQLRITNFESWSIDPLSIYHAAPLIFPFNQISNQCSSINGTCLLDFPNGATQMLYPLMVNGTIVNYGSNAIIFINNGNIFDGYYGGLLDPIAGKRLGWDDPYCPVKHQQSAICTNFYYIHVPEENYGSCMNFKSVTKITDSARNTTVSLNAEYLVTLTGFNVTVTNFTSSIPGSSYIYGPNIHYWQGAGGNTTNPAQSFPLQFGGQNYQIEWTLDANLPGYYGYGKVITGELIRRNGIFYKDDSIPYTVSDPCFKLTYAIPYYNNVTVETEFCCTLFASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEF6</accession>
    <name>A0A914YEF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEF6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17138.t1">
        <property type="protein sequence ID" value="PSU_v2.g17138.t1"/>
        <property type="gene ID" value="PSU_v2.g17138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="90"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17138.t1"/>
        </source>
    </evidence>
    <sequence length="545" mass="60669" checksum="F2AEBCB1AB50B975" modified="2023-02-22" version="1">MDPETGDFVRPARGSALPIHTDPEPIIQPRQLPRPEKEEKKQKKATSTNSRFIASISGRSWKRHEDEDDDGADNCIFGRQIRFTVMIISTLCLSSILSNILTFNFTYIAMPGNKPDNLSNMTKAEWEAYGYRPELDYSSAKRSTLFMAVAVGALVAVFPMTIMLNKFGSRLVFGVLGYISAIATLFVPLAANTGFIAMIIARFVQGMAFSACLPVMGSITSHWSTLKQNGIFIAILSSFLQIAPIFTMPISGELCTSSLGWESVYYLHGVVSIILFTLFILYHRNKPDNHPMVRRTELVKVMFGKGSIYSGPGKQKVSKKVPYAAMYKDPAIWAILVAAFGNFMGTQLSLQFMPTYINKVLYLPIAQTGIASAISPVIMFFIKLIAGQSSDRIKFISDPMKLRIYNTLAMGGMGVLFITLAFCDPRTQKSLCLVVLIASTCILGFNSGGFFKSSQMVSRQHSHFTMANISFLNCVCMLLTPLLNEIVAPENEPEDWVIVLWTHGIILLTTNAFFCFFCSSRPAIWTTGNLFIRNAMAFHNRKFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEH0</accession>
    <name>A0A914YEH0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YEH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15792.t1">
        <property type="protein sequence ID" value="PSU_v2.g15792.t1"/>
        <property type="gene ID" value="PSU_v2.g15792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20794">
        <property type="entry name" value="C1_aPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000634">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000070">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="207"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15792.t1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43674" checksum="59C29512E8A4C3ED" modified="2023-02-22" version="1">MVAMDEDDVKLKILYNKQALVVYYDPCTISSQPELEEALRLYKECQEAELRVHVFMGLPLNPGAPCQGEDKSIYRHGARRWNKNKFYHVNGHRFQAKRLNQRTQCTICNDYMWGLGRSGFRCVDCGMCVHKKCHRLVRRPCTTESLTPLYPTNIPPPQMTTIPTVTPEYVNGDHHNHLRNENEIEANGRIEPVVEDKQRWQVSIDDFNLLTIIGRGSYAKVVQAEHKLTKQIYAIKIIKKEMFNEDEESDWVQTEKSVFETASNHPFLVGLHSCFQTPSRLFFVIEFIPGGDLMYHMQRQRKLPEDHARFYSAEIILALHFLHTRGIIYRDLKLDNVLIDADGHIKLTDYGMCKENIGPTDTTQTFCGTPNYVSCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFX3</accession>
    <name>A0A914YFX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17663.t1">
        <property type="protein sequence ID" value="PSU_v2.g17663.t1"/>
        <property type="gene ID" value="PSU_v2.g17663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17663.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8752" checksum="7173701E72640096" modified="2023-02-22" version="1">MENLPEDVIYQEKILQEQRRRSSFSGRLKDSAKDLKDDIKDVGHIFVLTFKEGVHSLRTSVTLAASCADSISRDIVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG11</accession>
    <name>A0A914YG11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18254.t1">
        <property type="protein sequence ID" value="PSU_v2.g18254.t1"/>
        <property type="gene ID" value="PSU_v2.g18254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18254.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13559" checksum="9705E843F5EA51E4" modified="2023-02-22" version="1">MEVGDFTNPGWHGYNEERDNRGDNNAPRCPPYNFRSPINHWTHSKRILDVAEHNYHSRHLEQIDTENWLEEFQLHQNLIRDMTTENTPHETLNDLTKISYFLHAKFCELLDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGC7</accession>
    <name>A0A914YGC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18371.t1">
        <property type="protein sequence ID" value="PSU_v2.g18371.t1"/>
        <property type="gene ID" value="PSU_v2.g18371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000019">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000013">
        <property type="entry name" value="carboxypeptidase N catalytic chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF93">
        <property type="entry name" value="CARBOXYPEPTIDASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037181075" evidence="13">
        <location>
            <begin position="22"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="42"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18371.t1"/>
        </source>
    </evidence>
    <sequence length="509" mass="57456" checksum="186E98727E00C665" modified="2023-02-22" version="1">MASWHMNSLYFLFLFSTTVNCLFPFSSSSSSDDNSDSSEWTQYHNQEALEAKFADIAKKCPHHTQVYSIGKSVQGRDIVVIEFSTNPGTHESLKPEMKYIGNMHGNEAIGRELLIRLADHLCNGLNNKNEEIIKLINSTNIHLLPSMNPDGFELAFQTAPEDRGWLIGRTNAHGIDLNRNFPDLDSMFYYFENMEVNRYDHLLEYFKDDHSYEPEVQAIGQWTLSLPFVLSANIHEGDLVANYPFDASKGGSQQQYSKSPDDKTFRYLAETYAINHAHMAKNDHAPCDGTAGNAFARQGGITNGAKWYSVSGGMQDFNYLATNSFEITVELSCEKFPNGKLLPQLWKDNEKSLMEFMWLTHIGIKGLVTDAITKKPIANAVVWVRNATSTDGPIRHPVTSWITGDYFRLLTPGNYEVAVEAEGYETEIKAVNVTNSKKGETVILNFGLKPMPEEPMIENLPEDNTNDESMSDMININNQPVMTPERIDELKEIFSRIQEQGQYGPQVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIK1</accession>
    <name>A0A914YIK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIK1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18651.t1">
        <property type="protein sequence ID" value="PSU_v2.g18651.t1"/>
        <property type="gene ID" value="PSU_v2.g18651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF284">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18651.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34720" checksum="533589CF7CA3296C" modified="2023-02-22" version="1">MFAHGIHVLPGTHVMSHISVTIQQFLEKGLWGKCEEQKEEDVGRFHTLERCQQRCIKKLLLKECQCIPIYFGGNQTNCNQRKCIEMALNKIHPCNCSLPCHRIHFSVQETSMTKLISSFNNYSKITVAFKDKTLITQNQIQRLITVDLLSFVAGSMGLFLGMSCITLLEVFMYLFKAVWGTMNNARYKTYLSKLLGENVSNFLHADPDMSRSHEEIVITQTTNQDNPVSTNLPPVTLQIKQGLTNRKLSIQIGNNGGADAQMLILPRQQRFYAHSHRGIFSSFNSSFEAPTRQNSLKNSFDYDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIX9</accession>
    <name>A0A914YIX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20289.t1">
        <property type="protein sequence ID" value="PSU_v2.g20289.t1"/>
        <property type="gene ID" value="PSU_v2.g20289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044718">
        <property type="term" value="P:siderophore transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057601">
        <property type="entry name" value="Oar-like_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="TonB-dep_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069:SF46">
        <property type="entry name" value="OAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="TONB-DEPENDENT OUTER MEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25183">
        <property type="entry name" value="OMP_b-brl_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB-dependent transporter Oar-like beta-barrel" evidence="1">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20289.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35343" checksum="D96083F669CD176B" modified="2023-02-22" version="1">MRLDPRVTFIDRASGSISAGGQNPRYNSINIDGVSASDTFGLEGNNMPTRRQPVAMEAIEALDINLSNYDVSIAGAAGATVNAVTKSGTNEFHGSVYGTYRDGDWFGKNPEGKKFNGFNDEKTYGMTLGGPIVKDKLFFFANYEKFKQSAPGADLSSTALGKANADYSMADVTRAQEIAKGYGFDAGGIESNGNTDLEEYALKLDWNINENHRANIRYSKLEQSKLRINGMGSTSQASLSSYWYQHVKTNESYVAQVFSDWSDTFSTELKASYREYSAVRQVPTNAPSIRIYFPRGGDVTTPEGDSLFLGVELLRRRYADPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJG8</accession>
    <name>A0A914YJG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJG8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19660.t1">
        <property type="protein sequence ID" value="PSU_v2.g19660.t1"/>
        <property type="gene ID" value="PSU_v2.g19660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19660.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23063" checksum="DE5D12B7C9A32CA4" modified="2023-02-22" version="1">MWSSGEKRSPHVPILAGSNPHQCTPLMLPIGKLWKLLKNPQVERKIPKGWIDHRVVPAKGLLGLPDNIIHLTELAIPYLEKTKGNIINVSSALSQKTNQMSPFYAISKAALDHFARNYASLLASKSIRVNNLNPGVTETAFASRHGVTAEMRQKMIKLFPIPLNRWGTSEEMAEFLCFMASEKASYLTGQCINVEGGILIDSPTIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJM2</accession>
    <name>A0A914YJM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1906.t1">
        <property type="protein sequence ID" value="PSU_v2.g1906.t1"/>
        <property type="gene ID" value="PSU_v2.g1906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1906.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16534" checksum="E1E5B7EA87E1262A" modified="2023-02-22" version="1">MRSILNFVDRQICFQTKDLVTHLTTIHRYSPDDIANVTGNLLITSESPIIQSLSTTLNTTTSSSSGADTSGGGGIIADFGRTSLTTELKQIQKTLNELKSQRNVPHLTQAVNNLDTRIGRMEKQLEMVLNTLYTLVQLQTGNLSKSKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKA9</accession>
    <name>A0A914YKA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19776.t1">
        <property type="protein sequence ID" value="PSU_v2.g19776.t1"/>
        <property type="gene ID" value="PSU_v2.g19776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19776.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22234" checksum="92A18D6DBDBE7132" modified="2023-02-22" version="1">MKRILKNLQIRRDLIDQYDFHVRLKLFYPNDVLYYQDKFSFNVRDDAKINQSFLDIFQRQAECNPCGEALFNAATEIVPIRGVINTMIEQLRDTARARSKSGFYGYTQFAGMHVTRTLKLPICTYGTHRSLEIKVAENFEIVEEESSSNLEVTAKSEFFEIIEEEEASSSIEVLKEDESAGTAIPESEVIMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKC7</accession>
    <name>A0A914YKC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19980.t1">
        <property type="protein sequence ID" value="PSU_v2.g19980.t1"/>
        <property type="gene ID" value="PSU_v2.g19980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19980.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10746" checksum="4C48AE2BDD6C4A15" modified="2023-02-22" version="1">MVLFSLYPAFVERDLDFFSSQKENAANGEFSKEFQDKHMGRLIFRYKDSRIPDNYNTPALMKRLQDLRDLVHGFTLADRRLEFLRNLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKX0</accession>
    <name>A0A914YKX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKX0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17971.t1">
        <property type="protein sequence ID" value="PSU_v2.g17971.t1"/>
        <property type="gene ID" value="PSU_v2.g17971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF203">
        <property type="entry name" value="ATP-BINDING_PERMEASE FUSION ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17971.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11171" checksum="C76C579FC830E536" modified="2023-02-22" version="1">MSGWIMWTINGIFEDIGTVQDGITTIAQPLTVQDREDAVPLQVTRGGVHFQDIHFHYGKKGGVIAGLDLVVKPGEKIGLVGPSGAGKSTLVNVLLRLYDLEAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKX2</accession>
    <name>A0A914YKX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKX2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20183.t1">
        <property type="protein sequence ID" value="PSU_v2.g20183.t1"/>
        <property type="gene ID" value="PSU_v2.g20183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20183.t1"/>
        </source>
    </evidence>
    <sequence length="421" mass="46410" checksum="17DC31726E2C0BB4" modified="2023-02-22" version="1">MAPTSSAGSGGMATPEEITQSIEPDTLDIPYRDRKRRSSQARIVTAEQSVEIKKTPQSESIDGIQRGDIVEITTKTTLTTKEAKEESKTVKQAFHGGEASGIVELVRRDSQKKKAAKHVKEPTEKAANLVSELKAEEAQAKIKGRRTHSPASSVRLNVSEPGKVKVAEKTVITAPPQKEKTSKTFAIAETVKAEKNIKFGTKAARLSFEADKPEDEQNAFGVHSDAKTSAATNKAVKEPKLEKKDVSAEFEFVEHPEETSITQTTAALKKVKKTTHPPKSESSEIEADFEWIEPEEAAADFTRSASEKRKLAKTLKEAKNRQTSTETALEAKGRNESASFTSAKEAETAEKRVKAPKSENIAVKNLLEAVVVADAAELTTKEKIREDIKMKQNLKQKKKQKLFNQMKAKQKQAIKQQHQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLB9</accession>
    <name>A0A914YLB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19693.t1">
        <property type="protein sequence ID" value="PSU_v2.g19693.t1"/>
        <property type="gene ID" value="PSU_v2.g19693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19693.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19484" checksum="5F55381932231BF6" modified="2023-02-22" version="1">MDFSGGARDKREKYINIAAEMIRNMQLGEDATQIAFVRYSGLRRTDSVFHLKKHYNASEAIEEIDRTPTLGGLTRTGAAMLDAAKEFDRRFGGRTTAQKFMVVFTDAYSQDDPVDASAKLYQERVKVLAVAVDDASQPPDHEQLKAIATDQKSIFLEKDFPKLFTYFTQCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLF2</accession>
    <name>A0A914YLF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BCS1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18149.t1">
        <property type="protein sequence ID" value="PSU_v2.g18149.t1"/>
        <property type="gene ID" value="PSU_v2.g18149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18149.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32064" checksum="138A80297B4504EB" modified="2023-02-22" version="1">MWAWNFGNSLFRQKFFTTLQVTNDNMTYKWIIDHINRNSKWETQNLSVDTNLNQNETGAARLSHKLVPGLGSHYFYYKNRIIYFQRTREREQSTSHDARGYPVSNKCESIILSTFCGSTKFWKQFLDDASTEYLEALDKGLRIFAHTSHMQWETSGKLKNKRPLETVILEDGMVEKVCNDIENFLSSADWYLKRGIPYRRGYLFYGPPGTGKSSFIAALASHFGYGIATLSLTSAYSALIRPGRADFQVQLGHCTPSMIKRMFQRFYENVSDELVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLP3</accession>
    <name>A0A914YLP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20482.t1">
        <property type="protein sequence ID" value="PSU_v2.g20482.t1"/>
        <property type="gene ID" value="PSU_v2.g20482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20482.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14823" checksum="7954C226EB25A250" modified="2023-02-22" version="1">MSEAATDSPLIFDDSLAIEESVEISVADVTDEIETIEIDDSVTVDANTTTTKKKPIKSNIPTVLPLSKVKKICKLDSEINLVTADAVKLITFCTERFIELLAKSCVSCAKEQGRKTVSNADFRKPGNSKKLVILYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMY7</accession>
    <name>A0A914YMY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18691.t1">
        <property type="protein sequence ID" value="PSU_v2.g18691.t1"/>
        <property type="gene ID" value="PSU_v2.g18691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051310">
        <property type="entry name" value="MCP_chemotaxis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041395">
        <property type="entry name" value="McpB_HAMP_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43531:SF14">
        <property type="entry name" value="METHYL-ACCEPTING CHEMOTAXIS PROTEIN I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43531">
        <property type="entry name" value="PROTEIN ICFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18575">
        <property type="entry name" value="HAMP_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="169"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18691.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="27635" checksum="2763981734040EB6" modified="2023-02-22" version="1">MDAGAFPGDFGRMVQATNSLVESHVQVELLMAEVMQRYAIGDLSRDLPDYPGEKGTLTRTLAAVKQSLMAINAQIDELARAARAGDFSMRGDAAAFQYQFKAMVEHLNGMMASSQASIADVSDVLRAISHGDLTARMDGEYDGVFARMRDDANTTTAQLTGIVRGIQVAADSINNAAQELAAGNNDLSRRTEQQAANLEEAAASMEELTSTVRQNAELARQADSEAHAAGAAVRETEQAMAQMASVMGEIDQSPTSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPX6</accession>
    <name>A0A914YPX6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.6" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YPX6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2874.t1">
        <property type="protein sequence ID" value="PSU_v2.g2874.t1"/>
        <property type="gene ID" value="PSU_v2.g2874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004102">
        <property type="term" value="F:choline O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF14">
        <property type="entry name" value="CHOLINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2874.t1"/>
        </source>
    </evidence>
    <sequence length="630" mass="72145" checksum="BD21C255DC63BC7A" modified="2023-02-22" version="1">MFKIQNLLHNFVKNQAKQFLYYRNIAKKRLPKPPVPSLSHTFSRYLEYASAIAADDKQLEETTERVSEFLTNGTKFQDRLLELAEKAPNWVNCFWLPEMYLKPRYPLTLYSNPAYVFPKQNFQSEADCLKYTAWLVRGMLEFKDTIDNRLTEKDYVDKNQTIPMCMDQYDRLLTSYRQAVHGEDVLLRSPVNEDEHIMVMCQNQAFAVAVKVRGHLLAHSEIFYQLTQIAEAAKNRSKTNVAPIACATAGERDLAADFWAQAKLDPMNQESLNIVTNSIFNICLDLDPCPENKTIANEGQFILHGYGSNHAGLNRWYEHTIQLVVAINGTNGLCIEHSVAEGIVIIKMAEHALRFEKEQRAKKQIAAPKLKIKPRCLRWRVTSKMYEILAKQIAIFDELAGDLELVHTNFSDFGKEKIKSFGVSPDGFVQLSMQLAHYRMYNRVVSTYESASIRRFCLGRVDNIRSATPQALEWAKAMDSPRIPFKDKIRLFKEATVKQAMVTKENITGYGIDNHLCALSTICAEAAKKKEIPKQFEVFADQLWYDTMRFPLSTSQVTTSSDFDNSYLCYGPVVKDGYGNAYNIQNNKIIFATSARKSYRHTDAARFVNEVCRALRDMSAMVEKALMETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ57</accession>
    <name>A0A914YQ57_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQ57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2312.t1">
        <property type="protein sequence ID" value="PSU_v2.g2312.t1"/>
        <property type="gene ID" value="PSU_v2.g2312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000019">
        <property type="entry name" value="Kinesin-like protein KIN-5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="6"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2312.t1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51689" checksum="B49C8962B7F0A29F" modified="2023-02-22" version="1">MVNQENINVVARIRPFSAWIGTNRQSCLLIDPDNSTITVKSPTKNQKFEVNTVFNEDTTQASIFAKVGRSIVDGFVEGINGTIFAYGQTGSGKTYTMIGPDALEPNVSTFSDENRGIIPRALEDIFATLNAEVKKKPDSFKFSMKCSFLELYNERLYDLLQDNDATIKIQSCLEQITVVGAAEFEVTTYEECMHHLWRGWDQRKVAETSMNRESSRSHAVFMLTLVTEHTEGTVINRRSSRLNLVDLAGSERQGLTNNTGVQLKEAGNINKSLSILARVIRTLASSKPAQYIPYRDSLLTFLLRDSLGGNAKTTVVVNIHPNSEFVGDTISTLTFAVNVQKVKNTARVNEAITCDDIKSWKEEIERLRQENRDLKAQLDGNNNPKFISSPADTISVEDTTVFQSLMANLNDIDAKSESFLTESQKFRSAALNHLKLMMDASKAAAKEDTFDYDAEVEKCLIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQX4</accession>
    <name>A0A914YQX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Intraflagellar transport protein 57 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT57 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQX4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3179.t1">
        <property type="protein sequence ID" value="PSU_v2.g3179.t1"/>
        <property type="gene ID" value="PSU_v2.g3179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019530">
        <property type="entry name" value="Intra-flagellar_transport_57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011">
        <property type="entry name" value="IFT57/HIPPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10498">
        <property type="entry name" value="IFT57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3179.t1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45722" checksum="09C7A39B8D6A26A9" modified="2023-02-22" version="1">MDLNDSPAREFDQYSLNETVFERLELLNYEEEFVKQMESYKTIPRTYFVKSTNPGEQFFLFTNLAIWLMKKSGESGLQYPQEFDDPNATISTILAVLKAEEIPVDYSISAIKKGSGPACIHILAELSALALKKLNFDFTRFEVVEDNVEEGGEDEEAELGENAELTAEQFDDDDSGSVIDEDVGEATQFDTVFDEGTLLALDSNADKRLDYLVANDTQILQFRNEIERAVPQLKITIRSDAKDWRSHIDQMNKQLQSIKNNFLLAKPFLVETQKEIIDSTQRIEARERHINQQLSSLLGQYRTIQDRIAEKSQQYQEASGGITTRSEILQSLGEEVEQLKLQIEEQGARNNDAAPIIRIKQAISKLETQIISMNIQTAVIEQTIFNRKLRSLSNGLPYGNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR45</accession>
    <name>A0A914YR45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YR45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2488.t1">
        <property type="protein sequence ID" value="PSU_v2.g2488.t1"/>
        <property type="gene ID" value="PSU_v2.g2488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000049">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="187"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="482"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="843"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1019"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="808"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2488.t1"/>
        </source>
    </evidence>
    <sequence length="1057" mass="122781" checksum="5BD7B9CAC1E97780" modified="2023-02-22" version="1">MSQKSDTAKSDELPEMEVDEPEHDKVEEEPMETEEQEDQGIIEPKPKVEDIKDEDYGDEDIDIPVTKKKQGEIFVKKNDKKTVCFLVTLDPEESYNKFLKLLQKTETMARCLDAGDAAPQAPNSPVKTGRPSAQGDHRHRMTEKEEDEELMQQSKKTDTVFTFQKSPWYITGGQLRDYQIRGLNWMVQLQHNSINGILADEMGLGKTLQTISLLGYMKHVRQTNGPFLVIVPKSTLQNWMNEFQQWCPTIRAVCLIGTEEERKIIVSEQLAPGTYDVLVTSFEMVLRCMAFLKKITWKYTVIDEAHRIKNENSKLALCVRQLKSKHRLLLTGTPLQNNLHELWALLNFLMPEMFSNSEDFDSWLATSDKMNTEEIVKRLHRILQPFLLRRIKADVEKSLLPKKELKVYVGLSKMQREWYSKILLKDIDVVNGAGKIEKARLQNILMHLRKCCNHPYLFDGAEPGPPYTTDEHLINNCGKMVLLDKLLKRLKEQGSRVLIFSSMTRLLDMLEDYCWFRGHEYCRLDGQTAHEDRQNAINAYNAEGSTKFIFMLTTRAGGLGINLATADVVIIYDSDWNPQCDLQAMDRAHRIGQKKQVRVFRLITESTVEERIIERAEMKLRLDNVVIQQGRLSEAQKALGKDDMLTMIRHGADTIFAGKDSTITDEDIDSILKRGEERTKEMNEKLDKLGESSLRNFTLDTNNADSASIYAWQGEDYKQKQKASVADYWIEPPKRERKANYHVDLYFREAMKGGPVDNSKSQKAPRPKLPTVYDFQFFPKRLFELFDREIYSFRKQINYQAQKPTDVSPKEAEKVQKEEQKKIDDSVPLTEDEIIERDELLTQGFTEWTRRDFTAFVKASEKYGRTDLDAIATEVENKTKEEVVEYANVFWENIEDLTDHEKILAQIERGEQRIEKRQAVKQALDRKVAKYKAPFHQLRLPYGGNKCKNYNEEEDRFLICRLHELGFDNENVYDELRESIRTAPQFRFDWFIKSRTPLELQRRCQALIAMIEKEMERELLEEKEKNKRGKKSATTAPAKPTSSATRNKPGPKPKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR97</accession>
    <name>A0A914YR97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2699.t1">
        <property type="protein sequence ID" value="PSU_v2.g2699.t1"/>
        <property type="gene ID" value="PSU_v2.g2699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="38"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2699.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20443" checksum="973D5F215539B26D" modified="2023-02-22" version="1">MNIQDGTWFSDNYENFKQFVCVMEAPSPCPHGWTYNSRSGYCYFVKEGLASWEENEDWCFSQGGAHLASVHSDDENNFITNLINFSEGEGYICGSDQLAWIGLYTVTNQTTWRWTDNSLFDYTAWATCKPDNAFRGANCAVIQNPQVCRNCTINVGNLRSWSDAMCYDNYKFGVCKKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRJ4</accession>
    <name>A0A914YRJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2277.t1">
        <property type="protein sequence ID" value="PSU_v2.g2277.t1"/>
        <property type="gene ID" value="PSU_v2.g2277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2277.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12095" checksum="F8AFB92D81CA43F6" modified="2023-02-22" version="1">MDLPTFEYQKLNGYRHNYHIEKTSPSKWLKPLNVALPDYIDWRKEGYVTNVKNQGRCGSCWAFSSIASLEGQHKRATGKLVSLSEQNLIDCSAAFGNLGCNGGEINNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRM6</accession>
    <name>A0A914YRM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2824.t1">
        <property type="protein sequence ID" value="PSU_v2.g2824.t1"/>
        <property type="gene ID" value="PSU_v2.g2824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058770">
        <property type="entry name" value="PWI_ABCF3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26051">
        <property type="entry name" value="PWI_ABCF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="200"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2824.t1"/>
        </source>
    </evidence>
    <sequence length="559" mass="63836" checksum="7DE1A9434E5E3537" modified="2023-02-22" version="1">MVVAGLTSPENTFTLKSSDNAKIVKQRIDEYLFKQIPTMPVQIKEWVRDLLVENEDEIYSVEELTDAVGEHIHGSNKDITRETVLRICERLFELLHQGKTVENRREDAARKLDTTVDMSVQVDPYKNINSIWKVSAKDLPTLVVDKKKLLKAEGRNKDKAAKRTEEGAAAPRRVKPQIIATASQTIGKRTDTEGGNCLDIHLENVDISFGNKQLLNGADCTLSYGRRYGLVGRNGLGKTTLLKMISCGQLKIPSNIRMLSVEQEVDGDDTLVLDSVLACDVKRETLIREERELREQIDNPSTTDDERSELSHKLQDVYGEMSAHQVEKAPALAGIILFGLGFKPDEQRRPTKEFSGGWRMRVALARALFTKPDLLLLDEPTNMLDMRAVYWLESHLQGWQGTIVTVSHDRKFLNTICTDIVHLHTRRLDGYKGNYESYEKQMREKLTLQQREFEAQQQLRQHVQEFIDKFRYNAKRASMVQSRIKMLEKMPILKAVEFELDVVLRFPSCEKLQPPVMQLDEVSFRYNKDCDYIFRNICVGSDSDSRICIVGENGAVSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSC0</accession>
    <name>A0A914YSC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catalase core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSC0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3066.t1">
        <property type="protein sequence ID" value="PSU_v2.g3066.t1"/>
        <property type="gene ID" value="PSU_v2.g3066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF61">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3066.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21612" checksum="D798A368AFA17DD3" modified="2023-02-22" version="1">MSAAWDFWSLSPESLHQVTILMSDRGLPCNLRQQHGFGSHTYSLINDKGERHWVKFHFKSQQGIANYTNEEAAKVVGQDRESSQRDLYENIEKGNFPRWALRIQIMTEEQARTYHINPFDVTKVWPHGDFPLIDVGMLELNENPTNYFAQVEQAAFTPANLVPGIGHSPDRMLQGRIFPTATPSVTVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT30</accession>
    <name>A0A914YT30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3847.t1">
        <property type="protein sequence ID" value="PSU_v2.g3847.t1"/>
        <property type="gene ID" value="PSU_v2.g3847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3847.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19155" checksum="7A1A44FD1E74D1FF" modified="2023-02-22" version="1">MFARSVSNASFVALKTVQRQNQFRLLNASAVALRDKNVMDQAKEGAQNLVEKAKETIQHAKDQVGANNIVNKANEAMEHAKEKVQNMANNVNQKGVSGAASEAFQQVKDTVTDAKNSVMGDGSGTTPAAKGKSSTYDPRGSQKHVEEIIQVNKDHFKVIDKKLGGTGESKAGFDPKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT85</accession>
    <name>A0A914YT85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT85"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20647.t1">
        <property type="protein sequence ID" value="PSU_v2.g20647.t1"/>
        <property type="gene ID" value="PSU_v2.g20647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037298857" evidence="2">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20647.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="11965" checksum="513287BA4963B1BE" modified="2023-02-22" version="1">MISLATVISAAAIWVVSSTDIGAADSFESGEVSSFVGANVVISTSVDGIEVSGTTGISAAGAGISGADVSSGATALGASSYPPLPEGCDAIGAGGSSDEEGSDGVDSVTSLTGDSGTEGTKVVSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTD8</accession>
    <name>A0A914YTD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2935.t1">
        <property type="protein sequence ID" value="PSU_v2.g2935.t1"/>
        <property type="gene ID" value="PSU_v2.g2935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037777887" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2935.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="6890" checksum="3B9DD050CB128B62" modified="2023-02-22" version="1">MNKTIFACLLVILIFGVLAEAQFYGGYPGGYGYGGGFGRRGFGGPGGFYGGYPGGYGYGGGFRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTS7</accession>
    <name>A0A914YTS7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Proteasome 26S subunit ATPase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTS7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3397.t1">
        <property type="protein sequence ID" value="PSU_v2.g3397.t1"/>
        <property type="gene ID" value="PSU_v2.g3397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000075">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="210"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3397.t1"/>
        </source>
    </evidence>
    <sequence length="435" mass="48787" checksum="E7E9B2CC81EA27A4" modified="2023-02-22" version="1">MPDYLGEDQRKQKKDKKEEDDKPYQALDEADIAVLKRYGQGPYTEQLKQLETDIEDCLKRVNELCGVKESDTGLAPPALWDIAADKAAMQQEQPLQVARCTKIITTEGQEPRYMINVKQFAKFVVDLADTVAPTDIEEGMRVGVDRNKYQIHLPLPAKIDPTVTMMQVEEKPDVTYADIGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLYGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAVGGARFDDGMGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALVRPGRLDRKVEFALPDLAGRAHIFKIHAKQMSVERDIRYDLLARLCPNSTGAEIRSVCTEAGMYAIRARRKVATEKDFLDAVNKVIKGYAKFSATPRYLTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTT1</accession>
    <name>A0A914YTT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTT1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4077.t1">
        <property type="protein sequence ID" value="PSU_v2.g4077.t1"/>
        <property type="gene ID" value="PSU_v2.g4077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4077.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10273" checksum="807E06FF8A3B9F50" modified="2023-02-22" version="1">MESVHTALPTTPVAAVRRISSPPKLKTDSTQPSASAATAYEKSVNFGVQNAKHFSDGGVKTAEEKTKEPLEELTLFQTAFPKMDVDPSKPFSNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUE9</accession>
    <name>A0A914YUE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajQ family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUE9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3291.t1">
        <property type="protein sequence ID" value="PSU_v2.g3291.t1"/>
        <property type="gene ID" value="PSU_v2.g3291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.860:FF:000001">
        <property type="entry name" value="UPF0234 protein YajQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.990:FF:000001">
        <property type="entry name" value="UPF0234 protein YajQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="entry name" value="YajQ-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="YajQ/Smlt4090-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003819">
        <property type="entry name" value="PRK05412.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="UPF0234 PROTEIN YAJQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476:SF0">
        <property type="entry name" value="UPF0234 PROTEIN YAJQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="YajQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="YajQ-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3291.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20770" checksum="7614646E09B1284C" modified="2023-02-22" version="1">MKGEEKMPSFDIVSEVDLQEARNAVDNASREVESRFDFRNVEASFELNDASKTIKVLSESDFQVNQLLDILRAKLLKRGIEGSSLDVPENIVHSGKTWFVEAKLKQGIESATQKKIVKMIKDSKLKVQAQIQGDEIRVTGKSRDDLQAVMAMVRGGDLGQPFQFKNSAINRDNVRFVHVRCGMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVG4</accession>
    <name>A0A914YVG4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3973.t1">
        <property type="protein sequence ID" value="PSU_v2.g3973.t1"/>
        <property type="gene ID" value="PSU_v2.g3973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3973.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18982" checksum="75F9958236727623" modified="2023-02-22" version="1">MESMESQALTPSQSQGLIACCECGHAIPPNPTNMCVGCVRSRVDITEGIPKTAQLFQCKFCLRWHIPPTSWTHAELESKELLAHCLKKIKATITKVRLVDANFIWTEPHSKRTKVKLTVQREVFTGAILQQAFVVEFTHYNQICDECRRAEAKDYWQNSLLFGTTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVL7</accession>
    <name>A0A914YVL7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intraflagellar transport protein 46 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT46 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVL7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4176.t1">
        <property type="protein sequence ID" value="PSU_v2.g4176.t1"/>
        <property type="gene ID" value="PSU_v2.g4176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022088">
        <property type="entry name" value="Intraflagellar_transp_cmplxB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12317">
        <property type="entry name" value="IFT46_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4176.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12351" checksum="87EECD297F7E3FA2" modified="2023-02-22" version="1">MTNDLKALLAVIEQYHVPNIEIEPYLVPFDINYIAAVGDVHPGFGIPRPDGLEDHLGLVVLDEPAGKQSNSTVINMILSKDQAAADVPIKKLQRADRNTRQIDQWIENIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW46</accession>
    <name>A0A914YW46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW46"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4788.t1">
        <property type="protein sequence ID" value="PSU_v2.g4788.t1"/>
        <property type="gene ID" value="PSU_v2.g4788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4788.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29418" checksum="7A15C741875DA550" modified="2023-02-22" version="1">MISVANEIASDTFGVFPTVLSPGDPFTLILRASDSIPVMEKDNIFEVPFSVSQLNSPNETQKFSLFVKILPSEAELPRIWKSEQNFKLSQRLTNGIVGKIGIKNLDKTDLELFNYKLFGGFSELFSIETAKEGLFLRTFGCSPELCIQLPEAFTLLLRITPIKPMSMLNETEIALLHFQISRENLLGPHFSQHEYDATIYEKSAYFLETLQLEASDSDFHSSSEIIQHPIFSLSEPSEIFQIDSLTGVLSVKIILKYKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXC8</accession>
    <name>A0A914YXC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5162.t1">
        <property type="protein sequence ID" value="PSU_v2.g5162.t1"/>
        <property type="gene ID" value="PSU_v2.g5162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028796">
        <property type="entry name" value="BBS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5162.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40534" checksum="9972A110F1CFFACD" modified="2023-02-22" version="1">MARPETRLKTGTMEQALRTSRTSRTARAVSSSTARQVRLGTASMIAQQDGPFVNLGRLNVDKYATDPQINRYLFEYIFMHEGDMRLAHQIAAAATKKSEYKDWYWKNALGKCYYRLGMLREAEKQFISSLKNLKMVETYAYLSKIYARLDQPLTALDYLKSGLTEYQNDVTLLTFTARIHEQLGDLENSVESYKKVLKQAAGNIEAIACMGTHYFYSDQPEVALKYYRRILQMGVNRSELFMNIGLCCFYCQQLDLALACIDQALAIANDDVSADLWYDAAHIMLANCHNKMAQRCLRLALAANPDHAESLCNLGVLKMHEGHHIQAKNLFLSAVSKGPYLFEAHYNLALICSRVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYE0</accession>
    <name>A0A914YYE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYE0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5113.t1">
        <property type="protein sequence ID" value="PSU_v2.g5113.t1"/>
        <property type="gene ID" value="PSU_v2.g5113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5113.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23217" checksum="60517BE056A8ACED" modified="2023-02-22" version="1">MDSSDHPQTTNSTESMSSDTADNSSMMALSKRDIFLSTYNRRQKFTFPDSIMHYIAKNPKNATVYQKMIKRCKYFFIKNPILVFSWLRYGQNGWETTVKDDWKSIDMNKLSSKLWITDGLMVYPEDVSNVASSIIPKIYRCDVKRLDLENQVISLNELIFLCSSVKELDLLRITVKNDDDTVVLFEEFVKQLPQLNRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ27</accession>
    <name>A0A914YZ27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ27"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3288.t1">
        <property type="protein sequence ID" value="PSU_v2.g3288.t1"/>
        <property type="gene ID" value="PSU_v2.g3288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3288.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17565" checksum="1160D809062E5DDE" modified="2023-02-22" version="1">MKHHNDKTKRGERIINSNVRFDWIKIVAALKKRHIRNYGPMGLYSPYLGYGEYPKEGIQCPYKDCETWFTNHATILPSKERQYLLMEQLKVVNKNFQRLHYLDFFDSHLTKDHGFEARKKIFVCRHPNCNESRAVYASTELRTHFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZC7</accession>
    <name>A0A914YZC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5303.t1">
        <property type="protein sequence ID" value="PSU_v2.g5303.t1"/>
        <property type="gene ID" value="PSU_v2.g5303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043543">
        <property type="entry name" value="PAPPA/PAPPA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46130:SF3">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_33, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46130">
        <property type="entry name" value="LAMGL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LNR" evidence="5">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="6">
        <location>
            <begin position="432"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5303.t1"/>
        </source>
    </evidence>
    <sequence length="573" mass="64417" checksum="EF7CD7E0A71FCFF2" modified="2023-02-22" version="1">MKEKKRVDILNDNFKLEITVFIEGGQMPDVSILELTDICSDKTLIKFGIQSEDSDGERDLRFLISLKEDSIKVVGGNQIRTNVESKVVFYISDKEILLIIDGAKVAKRYFSNIFPLFHSSQFPCIRFFVGTDKSRERLIGFRGGIKDLKISSTSSNATFFSEPFSNLSSWNILGSTLSVWESFHRPFMASLPFPNFIPIPQCGLTECDNSEVILNYASSFQSLKTLSYTLVVVSNDDGTNSIISQNQIDLQHLALIEAFRPYNITFALNVTRIQRSDLRNKILIFGCASANVGDGICQKECQSEITGNDGGDCAPLNYISKCHSQMIRNGKCDSDCNIQKYDFDGGDCCLFHGIEGNCIDPKNPYRRYMTPHEYKQAINLPYLPSLIIYFANWPFESLVGLSTFPWESEATSPSGGIILQPHRFGISGQMGHLIHEIGHVLGLWHVHHGITEVACDDPCFEEIGSLETGDLVADTPPSPKNDKCEATNLHHFSCGKFRSFFDAPVKNYMSYSLGGCSDHFTPQQVARMHCYIDLKYSGWQRQRIMKSSNNHITVKPRILPNIIGNLTLVRILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZY8</accession>
    <name>A0A914YZY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5184.t1">
        <property type="protein sequence ID" value="PSU_v2.g5184.t1"/>
        <property type="gene ID" value="PSU_v2.g5184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5184.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12174" checksum="FB45E7B1EEF70F94" modified="2023-02-22" version="1">MPKLERWFRQDPHPPRPKLQSYMNILNSTAYRKTNSKVTYQQISNWFTNARAQQRNSNSFTSQQTTSQIPVATAPIDIRTKFNASNGYNSLLLDRQSETDVSCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0W0</accession>
    <name>A0A914Z0W0_9BILA</name>
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        <submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="227"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6361.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31740" checksum="DA054BB98ED656FB" modified="2023-02-22" version="1">MEEFNNLLKKALLKDYVPKKDVQQNEFLKKYPEFDGRGIKIAIIDSVVDLSLSGMQKTSTGLPKIIDCFDFTDNGNVDTSVIRKSGDDNTLTLLSGREISIPPNWKNPLNEWHLGKKFLQEIFPSLLEKMEEKEKLNENDIQEFPRFVDKIVAEKLSDNYNFDFIVWNDGKKWQACLIPSFLKHVENAKVLTNFHDEHQFCYLLDDISCGIRIEEGGNFLKLLICCHDHGTLVAQVVAAHFPNEPEKDGLAPGAQIISINFMGENVNVSTIKKANPKRA</sequence>
</entry>
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    <accession>A0A914Z1E1</accession>
    <name>A0A914Z1E1_9BILA</name>
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        <submittedName>
            <fullName evidence="4">NADAR domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
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    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="130"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5708.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="37223" checksum="B3E5830F3E03B696" modified="2023-02-22" version="1">MAEGAQPNGNRQQNYGKPGGNRQNNGNNGGNFNVQQELNGIKQEMSQLRDTVDMLEQEKDSLRKAIRKLKLENEHMKKKYKRLQEKVGDDRDGDESAEIEADYDEIGRDFILVGGIHDPLALRFQANIKDENGIQHKSAERYYWYKMAEVFNDEAAKKGILDAQSFNDAEEAMKEIKDFKESTWNEHKMKVWEKSQTLKLEQNRWIANLLVFSDKTYIAVATQDKYFGTGWRKNRDEANKPIYWDGENQGGKSLMRLRKLFRQNHEWKENEEDETRVKYNELRRYTWRRVDPTKRFQMNGHARGRRGNFRPYSAR</sequence>
</entry>
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    <accession>A0A914Z1H4</accession>
    <name>A0A914Z1H4_9BILA</name>
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        </submittedName>
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    </organism>
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            </authorList>
        </citation>
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    </reference>
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        <property type="gene ID" value="PSU_v2.g4118"/>
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    </dbReference>
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            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4118.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9821" checksum="52C052D0F8E6FC0D" modified="2023-02-22" version="1">MLEWILNHISSSKNAKSSDRLNASNSQINTAKISDLKSNIEEYSPPDPSKPSTNVVNHAEQGSRGGLFFSRCFDNSDCAYAALAMFKEH</sequence>
</entry>
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    <accession>A0A914Z1J7</accession>
    <name>A0A914Z1J7_9BILA</name>
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        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g5992.t1"/>
        <property type="gene ID" value="PSU_v2.g5992"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5992.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14422" checksum="CF723B50BB102617" modified="2023-02-22" version="1">MNCLKDCLATIFTKLESKDLQNLRLTCNIFDSIISKLNQRKSINILQLNGNSRGKIYRFSHSNAPIYDRYGFNQNEIDKGLKLLYAKKIIFDNVFIDASVSKALLLGIDYCLDEIVFDFCHFQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2K4</accession>
    <name>A0A914Z2K4_9BILA</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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            </authorList>
        </citation>
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    </reference>
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        <property type="gene ID" value="PSU_v2.g6940"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6940.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12082" checksum="45423267846317DF" modified="2023-02-22" version="1">MIPLTIIVAEFFIYGSLVTIFLIFGCAKLKGLKGGGKPADTKPTTPAIVPVPNTTTAVPAPPTSAAPNIDKNTVSMQPTEDPDLKSRENYDIKTTDETYISKIKTQKPPPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2W5</accession>
    <name>A0A914Z2W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2W5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4597.t1">
        <property type="protein sequence ID" value="PSU_v2.g4597.t1"/>
        <property type="gene ID" value="PSU_v2.g4597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF8">
        <property type="entry name" value="FORMIN-HOMOLOGY AND ZINC FINGER DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="59"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4597.t1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47953" checksum="BFBFA6D1309EAA19" modified="2023-02-22" version="1">MVSLHGITGDPISYMDEYAEQVEEFMKKCFPNEEAVAADNETLLLKEETPSSFVRDFFTPSLASEKSEIIASLPNSLIENEQALYTNFPHRFVCSTQIKGTVFETFTNSSDLIDRIDLTEMAVFFENNNRSLLNSDQIRIVSEVRRQLPKKDFEIMFALYKCDTSLLSLAQINLIKLIAPSEVDARRFKTFCEANSVSSLSEEEKFVIELSNIEQLFIRLRLMETIHTFPEMVYNLQQEINILRDVAITLRADTFFTIILQCSTIYTNFLCGDFGAQLIHGIRVIEALNVCKYELPNGIKIGKRIADMLPINALGDTVAKRLKLYQEASQYNFSTLETRVKKLGECLLQLDAERSNLGTDCAPSSVGIVVQEARLRESLTTAQNEMTTTLQYFAESSSTSATIKPENFIKNVTELLQFLINVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z340</accession>
    <name>A0A914Z340_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z340"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6771.t1">
        <property type="protein sequence ID" value="PSU_v2.g6771.t1"/>
        <property type="gene ID" value="PSU_v2.g6771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31192">
        <property type="entry name" value="SPERM-SPECIFIC FAMILY, CLASS Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31192:SF4">
        <property type="entry name" value="SPERM-SPECIFIC FAMILY, CLASS Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6771.t1"/>
        </source>
    </evidence>
    <sequence length="440" mass="36980" checksum="AEDC33E5495FC285" modified="2023-02-22" version="1">MAVSCYLGAGAAKGGGAQSAYFTPGGAPGGGAGGGGGGGVSGGNAPGGGGAQSAYFGVGGSGAPGGGGATSAYFSVGGGGGGGAGAPPPPSGGGGAPMGASTMTAVGAPARGQSTMTAVGAPMGGGGSSTMTAVGGAPMGGGGGSSTMTAVGGAPMGSSTMTAVGGAPMGGGGGSSTMTAIGGAPRGQSTMTAVGAPMGGGGSSTMTAVGGAPMGASTMTAVGAPMGGGGGASTMTAIGGAPRGQSTMTAVGAPMGGGGSSTMTAVGGAPMGGGGSSTMTAVGGAPMGGGGGSSTMTAIGGAPRGQSTMTAVGAPMGGGGTSTMTAVGAPMGGGGGSSTMTAVGGAGGAPSAPMGGSPMASGAPGGGGATSAYFGVGGSGAPGGGGATSAYFGVGGGGGGGAKFGGGGGAAQPPGTSAYFAPTGGAGAAPGATSAYFAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3C0</accession>
    <name>A0A914Z3C0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">TATA sequence-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">TATA-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TATA-box factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Transcription initiation factor TFIID TBP subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3C0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g475.t1">
        <property type="protein sequence ID" value="PSU_v2.g475.t1"/>
        <property type="gene ID" value="PSU_v2.g475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g475.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26880" checksum="F615AEE1A9C440AF" modified="2023-02-22" version="1">MFGINQTPYGESSSYSMSLDVPKSPALSVTSEDHHDNPQTTEDTPMQSTIPMYIPQAISSTYEKPTPIIQNIVSTCNVGTQLDLKKIAMHARNAEYNPKRFSAVVMRIRDPRTTALIFSSGKMVVTGAKSEDASRLAARKYARIIQKLGFSVHFSDFKIQNLVGSVDVHFAIQLEGLCITHNQFSSYEPELFPGLIYRMVKPRVVILIFVSGKIVITGAKTREEIGEAFEQIYPIVKGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4M0</accession>
    <name>A0A914Z4M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal lipase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4M0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6845.t1">
        <property type="protein sequence ID" value="PSU_v2.g6845.t1"/>
        <property type="gene ID" value="PSU_v2.g6845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036950368" evidence="1">
        <location>
            <begin position="21"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="89"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6845.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32368" checksum="1A6D42E72776612D" modified="2023-02-22" version="1">MLLKKSCLIFFAVFISLGNGAYDESLARNIIWPITVDAYNHAVEKCISTTLGKDYDFGIQSTVQCDDISSKDSCSGYVIAIHSLKYVAIVYRGSISDHEVQVEMNYTATHPLIPFVGKGSVNGWLLNGYNLLWNAGMKDAFLKLKNKYPNYNILVAGHSLGAALASLTAATLSATNVVPKSRLSLYTFGQPRVGDKAFADNYLNLVPEAYRIVHHWDIVPHLPTLGLKGYTHHKTEVWYNNNMAKGDPYIICPDEESKKCSDSVLVPTWGDHGEYFGVRNYLGNHGCVPAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z503</accession>
    <name>A0A914Z503_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z503"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7430.t1">
        <property type="protein sequence ID" value="PSU_v2.g7430.t1"/>
        <property type="gene ID" value="PSU_v2.g7430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037114295" evidence="1">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7430.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35148" checksum="046476179028EAFF" modified="2023-02-22" version="1">MKLIFITFFFCSKIMIFLAQLPPPPPDKPDCSAGWQTIEMSYIPTLASCGDMEQDGGVPCQPNMITSCTGRNPLCAQMEDKSSFKCCSDIPQDSSDIETLQADQIKPLCPNGAIPFKMPQVMLCDPSIVNICPYDYTCVEAENGHLLPSDSRSLCCKTSTLYSFGKVFIEAGLTPKIVPNAPLSGIQYVKFDINILVLIDYPNSLLENMQFYYDRVCDGGKEINLEEPIPDGGFINKRVINGSPQLSPEQQSKSNYRKMWVVLVYKTVDPLTRMYISISTDLHAKYQNVVQFLRSPTAQRLGTPIAGSYFYLTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7S7</accession>
    <name>A0A914Z7S7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7S7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7951.t1">
        <property type="protein sequence ID" value="PSU_v2.g7951.t1"/>
        <property type="gene ID" value="PSU_v2.g7951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="131"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7951.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33318" checksum="520494B2FB732249" modified="2023-02-22" version="1">MPDKFYSWPDFEAEHEDRDHKGISALHKKLEPYLLRRVKKDVEKSLPAKVEQILRVDMTAQQKQYYKWILTRNYQELSKGVKGSINGFVNLIMELKKCCNHCSLVRQYDDIEADAQSRLQQLLKSSGKLILLDKLLCRLKETGHRVLIFSQMVMMLDILQEYMSLRRFNTQRLDGSMRADLRKQALDHFNAPNSSDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQNDLQAMSRAHRIGQKKQVNIYRFVTKASVEEEIVERAKKKLVLDHLVIQRMDTTGKTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7U3</accession>
    <name>A0A914Z7U3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7U3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6317.t1">
        <property type="protein sequence ID" value="PSU_v2.g6317.t1"/>
        <property type="gene ID" value="PSU_v2.g6317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="33"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6317.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16959" checksum="44ADF334C74620F3" modified="2023-02-22" version="1">MSQPSYPRSQDYNRTPRARPPRPNPPEDTYLTDAKKFMNLYYDTLDNKRDKIVHLYAATCRLLFDGNPFSSGDDINEFWQKRFPTSVHTIRTQDFKNHGDTFLILMTSGEVLLEAQRRTFSQVLVCQRQDGMWKIMSDGYRLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8C4</accession>
    <name>A0A914Z8C4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8C4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8582.t1">
        <property type="protein sequence ID" value="PSU_v2.g8582.t1"/>
        <property type="gene ID" value="PSU_v2.g8582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF9">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8582.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24929" checksum="BE03DC002D5EA9F8" modified="2023-02-22" version="1">MLNPDGVYLGNYRCSLMGFDLNRQWQNPSSWGNPTIFATKNLLIQYNNNPHIELCLVMDLHAHSRQTNTFLYGNLTTKDPKHCEQQLYIPYLLAELTEDYSLHFTQFNTDAEKAGTNRRAMGALLDPNCLCYTLEVSFFSYKPKDTSTAKSIPYFDYTYELLGENIAFSILNYNEILNGERTIAIKRSFESFLPKRCVKSYKQLGKSLKALDIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z912</accession>
    <name>A0A914Z912_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z912"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8817.t1">
        <property type="protein sequence ID" value="PSU_v2.g8817.t1"/>
        <property type="gene ID" value="PSU_v2.g8817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8817.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7604" checksum="5B0698981C3E616D" modified="2023-02-22" version="1">MANLSTPWVMIILSPEMLKGVKVVLRLSKDTEESRIFHIREPKTLPSNSISANALPTIATKPIVHIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z960</accession>
    <name>A0A914Z960_9BILA</name>
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        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z960"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8864.t1">
        <property type="protein sequence ID" value="PSU_v2.g8864.t1"/>
        <property type="gene ID" value="PSU_v2.g8864"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="113"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8864.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28054" checksum="2749241F9DA43E17" modified="2023-02-22" version="1">MYENVFINGEASNLFPNGDFWIGANNLINFGTWSWIDGTPFDFKDWDKGEPNNITGNKCGAVRTQAGLWFADDCYKNKSFTCLMTTSPSSSTIQPFDTTTVTPKKCPISWTSYNGFCYKVYENLNWLDGEDRCKIDYAHLASVHSLEEALFIGNLAYYQNINPCDWTQQAWFGLFTEDNNAHWNWTDGTPFDYSKWVPTQPDYPGDQNCGYIQLSNCPTGVTQQTGEFDNAYCDHVLPKIVCKKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAL4</accession>
    <name>A0A914ZAL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9362.t1">
        <property type="protein sequence ID" value="PSU_v2.g9362.t1"/>
        <property type="gene ID" value="PSU_v2.g9362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9362.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23871" checksum="5C9ADF89CA482980" modified="2023-02-22" version="1">MFAWLNQYRILNLRCILRSLAILINVVLVIELLTELFDPFDGILADSRNQRDTFCGSDCEECLGRPFRLPADVWTIYIKVLSVFFNLWLLSHLSVVFFPLFWGNWLFEHQEELYTFRSNIVIISVFNIFPLIMLGSHECEYARYFFLIAPMLIFTAVLSDRIFVRANDYFQLADYGVVAQGQWQEDVQWENVESHHENPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAY9</accession>
    <name>A0A914ZAY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7418.t1">
        <property type="protein sequence ID" value="PSU_v2.g7418.t1"/>
        <property type="gene ID" value="PSU_v2.g7418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="58"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7418.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23913" checksum="462DF4F32BD19E28" modified="2023-02-22" version="1">MADWDDAAAPVEVQEAPVVAAPLLDTQEIKVFNKWSLSDVEVSDISLVDYIAVKEKGAKYLPHTAGRYQVKRFRKANIPIVERLTSSLMSHGRNNGKKLMAVRIVKHTFEIIHLLSGENPVQVLVNAVINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAVWLICTGARESAFRNVKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB35</accession>
    <name>A0A914ZB35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cleavage inducing molecular chaperone Jiv domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9128.t1">
        <property type="protein sequence ID" value="PSU_v2.g9128.t1"/>
        <property type="gene ID" value="PSU_v2.g9128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032843">
        <property type="entry name" value="Jiv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052317">
        <property type="entry name" value="Viral_replicn-host_int_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44665">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44665:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14901">
        <property type="entry name" value="Jiv90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cleavage inducing molecular chaperone Jiv" evidence="1">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9128.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19400" checksum="21114E3E91547658" modified="2023-02-22" version="1">MLDQTYALQIQLDEYKYLINTKGAILHCECGENHTVTRVSNYDGRYCIKCNQSHPVKNGDLWVDKQYFGWVLTYYAVINNTIFDVTDWGNCAANCLKRLKPNPHMITHRLYNASVNAAVTNVTEKHRCSCRPDSSDRCTRSIVLPKDPLPWKYSCCCSLLLQLVFRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBA4</accession>
    <name>A0A914ZBA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9200.t1">
        <property type="protein sequence ID" value="PSU_v2.g9200.t1"/>
        <property type="gene ID" value="PSU_v2.g9200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9200.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13568" checksum="137590F56F4CE456" modified="2023-02-22" version="1">MLTTDRLKWGFTVDESGLLDNNNNNQLGEVYFIDYTAQSQMDICENSIKIPVQPSYWKKWTNNNLLKILQVYNHVVNGFTIEEREYQFFIDFIKTDFNVEVRFFIFWSFKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC16</accession>
    <name>A0A914ZC16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZC16"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9277.t1">
        <property type="protein sequence ID" value="PSU_v2.g9277.t1"/>
        <property type="gene ID" value="PSU_v2.g9277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9277.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11159" checksum="297D5345B5B538EF" modified="2023-02-22" version="1">MSRKTQRYSKKFKAEAVRTVLENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKATVDFAQESLKNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC67</accession>
    <name>A0A914ZC67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9323.t1">
        <property type="protein sequence ID" value="PSU_v2.g9323.t1"/>
        <property type="gene ID" value="PSU_v2.g9323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9323.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28130" checksum="46CDEEDF33D22796" modified="2023-02-22" version="1">MATRTSQIGYDTNSKDVERMKARVFVAGLGHNVSRDQIIELFACYGHITGATLFKGYAFIQYSNSTEADLATMALNGYTWNKSMLEVKCAFDPAKGGDLMPTKRPKRDGGPPEKRAKIDKNYQQQNQQQQQQHEPAAIAPSMTNNSTPVIQQAQANINQIPAQILLKTDIIPDMFICGGCQLYTNSFEAFIEHRQIPCSTSKSQKSEGEPEQFRCFTCSNAFITSWELLYHLRVSHEITMYKNLKDKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD00</accession>
    <name>A0A914ZD00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZD00"/>
    <dbReference type="WBParaSite" id="PSU_v2.g956.t1">
        <property type="protein sequence ID" value="PSU_v2.g956.t1"/>
        <property type="gene ID" value="PSU_v2.g956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g956.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7861" checksum="9791CBE83D915915" modified="2023-02-22" version="1">MKPINISAKTNACSHFTSTSTITYDANNVTYANVSIDYTLQNTNLTMIGKFSDLKTYRPYLVIDDAAACDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSH5</accession>
    <name>A0A914XSH5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914XSH5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10227.t1">
        <property type="protein sequence ID" value="PSU_v2.g10227.t1"/>
        <property type="gene ID" value="PSU_v2.g10227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="70"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10227.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35173" checksum="196C0BB943F8DBB8" modified="2023-02-22" version="1">MASKNRNRLNLSIPPVVAEEGNKDDTDDLTEKCDDEGVSELSGDQIKALQTFLTQKEQLFERGELCEDELERVSELGHGNGGVVHKMKHKKSGLVMARKLVHLEVKPSVRNQILKELEILHKCNSPYIVGFYGAFHENNEISICMEFMDGLSLDIVLQKVGKIQEQIVGRLTVAVVRGLAYLKQLGMLHRDVKPSNVLVNSKGEVKLCDFGVSGKLIDSMANSFVGTRSYMAPERLRGDGYTIQSDLWSFGLSLVELSIGRYPIPPPSRKEYSMLFNIPAEQIILEYDEESTGADGGPKNLAIFELLDYIVNRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSX4</accession>
    <name>A0A914XSX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSX4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10371.t1">
        <property type="protein sequence ID" value="PSU_v2.g10371.t1"/>
        <property type="gene ID" value="PSU_v2.g10371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10371.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24352" checksum="5DEF0403CB4F5CC8" modified="2023-02-22" version="1">MFSKPGLHPTDIDIYLAMSLMETDLHKIIHSTQELSEQHNQYFLYQILRGLKYLHSVGIVHRDLKPANLFINGDCLLKIGDFGMARSVAQCKPGTSHNPLTQYVMTRWYRAPELLFTFPTYDTKIDIWSAGCIFAELIMRRQIFPAKDSPSQIKMIVYYLGTPTEDVMNLVRESEIKKVIYDCGDKKGLPWSTILPKASPKALDLVSKVWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSY2</accession>
    <name>A0A914XSY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XSY2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11077.t1">
        <property type="protein sequence ID" value="PSU_v2.g11077.t1"/>
        <property type="gene ID" value="PSU_v2.g11077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11077.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38779" checksum="E41B4E22505C72E6" modified="2023-02-22" version="1">MSVFFIITNIISFVLKTHQNFRIPSITVSYDPHEKQTIDDNDFAGAIATFKQFTVPHPYFFYVDFACNIFFTIELLVRTIFAPSLRKFFRSPLTLIDLIATGAFYLDWITSDLVVHSAQADTIDFLSIVCILRLFKLTKHFAGLKIIIQTFKNSAEELLLLVFFVALAIVTFAALVYYAERIENNPNNQFTSIPAGLWWSLITICTVGFGDMVPKTYPGMLVGSLCALMGVLTIALPVPVIVANFSNLYSHTQARAKLPKKRRRVLQAHEVKVPSVLKHSKYRGKSDSMIPTDDENNETKITPTTRLVQPQPHKISSASSHIAAFFHMVQQQRQQPPMPHQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTC9</accession>
    <name>A0A914XTC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PARP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTC9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10522.t1">
        <property type="protein sequence ID" value="PSU_v2.g10522.t1"/>
        <property type="gene ID" value="PSU_v2.g10522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10522.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19738" checksum="CF79310F318CE200" modified="2023-02-22" version="1">MQDNWLHEPCFWKRARKAKLSEATIRGFEALKWDDQELIRKKIGPAKKAAAKKPTPKAHIPTIDTAKSSRALCFKCEKKFENGAPKIHLKGSNFHPECIKEMGVITVGAEKIKGFEDLDISQQKAVEKLFGNSNKRIAESSDAGKITSKKAKNIPDVSTDKDKAALKVIYILLLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTI2</accession>
    <name>A0A914XTI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11266.t1">
        <property type="protein sequence ID" value="PSU_v2.g11266.t1"/>
        <property type="gene ID" value="PSU_v2.g11266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11266.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8619" checksum="7FBD8A5171EB08A9" modified="2023-02-22" version="1">MITANPIIINSNAVKKMAETRGVTTAQIFFRFMMDIGVVPLTGTTNETHMKQDLAVLDMPSLSSEEIQMINDMLSDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXS2</accession>
    <name>A0A914XXS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12000.t1">
        <property type="protein sequence ID" value="PSU_v2.g12000.t1"/>
        <property type="gene ID" value="PSU_v2.g12000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12000.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23671" checksum="A67D48068554DC0E" modified="2023-02-22" version="1">MNFFKKEDPKEAQRSNDRQLRRTNRDLSHDYKQLERREKELEMEIKKLAKTGQISACKTLAKQLVQIREQKTKNIAMGARVTSVGHQAKTMGSMGTMATAMGTTANTMKIVDKQMPLEKFAAQMRDFQQTNDRMDMKAEVINDTLDSMLDVDEGEEEAVINQVLDEIGIEVRGKMPSVPMGTSDFTSTKTKTGNDISDADLDRMLASLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYK5</accession>
    <name>A0A914XYK5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYK5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12292.t1">
        <property type="protein sequence ID" value="PSU_v2.g12292.t1"/>
        <property type="gene ID" value="PSU_v2.g12292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12292.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11711" checksum="2C859E82491523E2" modified="2023-02-22" version="1">MPRKHIQSNKVRKRKAKDLDEIQEEMKPEKIPKKLTAEEAYDLPGNGEFHCVSCCRYFFNDDAYKRHIKSNPHKRQVKRLKEPAYTQAEANLAGGLGEPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYX7</accession>
    <name>A0A914XYX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SecA family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYX7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12416.t1">
        <property type="protein sequence ID" value="PSU_v2.g12416.t1"/>
        <property type="gene ID" value="PSU_v2.g12416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1440.10">
        <property type="entry name" value="SecA, preprotein cross-linking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612:SF0">
        <property type="entry name" value="CHLOROPLAST PROTEIN-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="Pre-protein crosslinking domain of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SecA family profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12416.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43445" checksum="04F3CCAF864E62A4" modified="2023-02-22" version="1">MLMLTDFNHPLKKENDKDSLKENLESMEKEFEALLSYISAFHIEVPDHLQSYVKRHLREFIINAENAFHLEEGVSYQVDITTNSSFKPKIIIIDRDTGVDLPTTQWHKGLHQFLQLKHGLNLTALSTKAVFISNVSYLKKFKAIYGFSGTLGAKDERKQLDEIYAEEEKQKSNTLSDDLFKAFDNSTVYKRDSEQFAYGNGEKKLETKSIIFATTLAGRGTDIRLTEELKSNGGLHVIIAFLPRNIRIEEQAYGRSARCGEAGTAQLIVYDPNSQSNANILELKWKRDRAETKRIQSIIQHYESKIKTEEQCFMTFCNVFQKLTSDMKENQYTRILSKDLLDRWALWLDEAESKWFKKEDCAKQSPMFQAKKFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ10</accession>
    <name>A0A914XZ10_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZ10"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11774.t1">
        <property type="protein sequence ID" value="PSU_v2.g11774.t1"/>
        <property type="gene ID" value="PSU_v2.g11774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF191">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038124543" description="Sodium/hydrogen exchanger" evidence="14">
        <location>
            <begin position="25"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="15">
        <location>
            <begin position="88"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11774.t1"/>
        </source>
    </evidence>
    <sequence length="625" mass="69815" checksum="1A103673C068B7B6" modified="2023-02-22" version="1">MSHSVLHFLLITGFLIIFVTQISGDSADNVDILDAAGMQIHNISDPLITNNTIDKLPLVDAPDSPENSQVEEQKDSLAIFFILLVLVLSIFLVHLLILTEIHFMPESLAIVLLGATIGLILSYTKWDWTEVETFNPNIFFLVLLPPIIFESGYNLHKGNFFANIVPILTFAIVGTAISACVIGLSLYILGQADLIYPLTATESFAYGSLISAVDPVATLAIFQALKVEGQLYMLVFGESMLNDAVSIVLTTTCLEMSRPEMADLTPFETFQHGFGRFTSMFFFSAFLGSAIGFISALIFKHVDFRKTPSLELALLFIFAYLPYGLAEAISLSGIMAILSCAITMSQYTHFNISPISQITFTQTFRTLSFVAETCTFVYLGLALFTIKLVFQPIFLVWSLVLLFVSRAANIFPLSFLVNKCRRPQVSMKNQVIMWFSGMRGAVALVLVLHMELENKETKQILLTTTLFVLLFTIVFLGGSTLPLIKILTNIFPDERTSKQLKKKKSRKQRSQKSGRVRKSSPVLLSKTQEMANFDNSEHLTATEDESGRGSRMGHRKNIFTRINETLMKPLFVRRFTQQEKNDNKMRFRNIASEALKHPDGTVGLISQNNSSSEELFTPSTPLLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZB5</accession>
    <name>A0A914XZB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZB5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13290.t1">
        <property type="protein sequence ID" value="PSU_v2.g13290.t1"/>
        <property type="gene ID" value="PSU_v2.g13290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13290.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38230" checksum="F4B5EA870D94E752" modified="2023-02-22" version="1">MNLLRAALGAHKADFTYWDNVLSNEAAWNAEFGVDQKYRIPLFGTSKTYQRHLRVFHPNGNIYGPFRPANWMELQVYALVPPPIQPEPAPPPPIQYEEDVEFDAAMMEPFDGEEIILENALQPPLEPDPAFKPYKSIHLCQPYLPDQESFRIDSMLKSKLHPFSSEYLRRQYLSNNGLYIKPEEVVTGIDLDVAANPRGTQIRERRNIVAVLCLSTFTNSATLCHPFAGRRAQNLLHAIGEDCLLIELYMDEFTTSCPIGNTASIYKMAGFYIRLLNLPLDMISQLDHIMLACLAHAVDVMDDLQEIIRLILLPQLKKLELDGVTFRYQGTEKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZT5</accession>
    <name>A0A914XZT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZT5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12717.t1">
        <property type="protein sequence ID" value="PSU_v2.g12717.t1"/>
        <property type="gene ID" value="PSU_v2.g12717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12717.t1"/>
        </source>
    </evidence>
    <sequence length="538" mass="62718" checksum="0C960E7EFD286FA3" modified="2023-02-22" version="1">MTTKKENDNGDILNAETEGTHEVQLIGMDDLDILKDTEFFDYLLQTLTDHYAKLSGLKNVKIRAEFTKEFFARYWLLLMKCAEFDIVPPVNVSDDISAFDSIHRSIFEICESRINLRITTHFILRAEKLANEDEIEARNLFMLVLLFVSEWIADEKENSPNLTFKQSMAKEVHECFCKLFKEIFHGDNEDFKNRVFNENKEMSHSSPLPFHSSPNRSFDTPSLPSLNITPNVQVSAHEKNAQNEFLKKEIGELKVVVSSHVMDEEKLEKENNVLQRELAEKRLEIGDVNKQNVEIVEENRYLQQDLNKKKNELSEANNLIIQKEAEMKFIVNEIESLTGVINSLQMKYDLCNDELSKNIVESNCLKEENEELEKAVNRKTRTAEKLEEEKNVLRHELAEKRLEIGDVNKQNVEIAEENRYLQQDLNKKKNELSESNNIIIQKEAELNVIVNEIESLTGVINSLQMKYDLCNDELNKNFVENECLKEENEKLEKAVNRKTRTVEKLEEEKQVLQQALDSKTMELNEAKQLFSRLSYNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y056</accession>
    <name>A0A914Y056_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y056"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1260.t1">
        <property type="protein sequence ID" value="PSU_v2.g1260.t1"/>
        <property type="gene ID" value="PSU_v2.g1260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF240">
        <property type="entry name" value="PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1260.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11680" checksum="7FE821A7A749C7CE" modified="2023-02-22" version="1">MSVYSGTSDMSDSSNATIETTASAPAISEIIREQPKPSVDKIMPTIGGTDIVKPTSNQLSITDFTFVKVLGKGSFGKVLLAEKNGTDEVFAVKVLKKHVILQGLTFFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0S1</accession>
    <name>A0A914Y0S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0S1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12385.t1">
        <property type="protein sequence ID" value="PSU_v2.g12385.t1"/>
        <property type="gene ID" value="PSU_v2.g12385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037181539" evidence="1">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12385.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23541" checksum="E36CFE087E74E91F" modified="2023-02-22" version="1">MFHLSTLSLIYFLLLSTVIYSSPQHRYQRDAATEFPQYGDLDLVLQNGDDFLEFRICCTDSYGCYPGSFQFCFETTKQEQSSAGLNGCGGGTCAYKLDYDSKNHYSFFISSLLTTDECLTGKITDKNMFVTYSNTHKEMPGCPLAIKSGNRLKLDVRSIPHGVTVTAINAQQYSEPTSTSAPKNDTSETLADEAGMSDGLKFGLIAGGLIVIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1P1</accession>
    <name>A0A914Y1P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1P1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14107.t1">
        <property type="protein sequence ID" value="PSU_v2.g14107.t1"/>
        <property type="gene ID" value="PSU_v2.g14107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF74">
        <property type="entry name" value="LP13728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037195495" evidence="13">
        <location>
            <begin position="23"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="602"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="452"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="759"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="890"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14107.t1"/>
        </source>
    </evidence>
    <sequence length="956" mass="108501" checksum="47DE8CD70307A4C7" modified="2023-02-22" version="1">MKQSVPWQLFLIFLTFVQICAAFSNAPTSFLFEKSCRGVEYNSCKCIIRTKETKCCCLGRIEKVTESINVLFLYKPDFIYIDRFTFKNYTKLQEIIIDSATELSAIDGRAFDNLPDLRKISITAAPKLIEINGTLLLKNHKLQSLIISNTSLKRLPNLKMSISHMLTMDIIDFSQNQISYVGNGQVSGIHARTLKLSGNEISYIHEKAFAQSKFVSLYLNDNHELATMSLLAFADISELHQLDLSETSISELPVIGLKDIKHLILKNVPTLKKLPPVLAFNNLNKAEFTYPYHCCFFKHASRDYAVGQGSQYSSHYKEIQQRSCTREALKSPEVQKLLRKKRETSATTDPLIDSLSAWFDLMDSQNTQIDINSTEDEEEDEFDVFDGLKAYPADEVGNSRILQRCLKVAVDRFYLNISCSPVPDALNPCEDIVGYWWLRYIIWGIWIMAIFGNVLVWIVIVTIWHRRSRLHYFFMVNLSIADFLTGIYLGILAMKDAFTANEYYNYAVEWQTGWGCAVAGFLSVFASELSIVSLLWIAFEIYYNARFAFYGKRLTSRNAVPLMGIAYLYALIMASLPFFGVSSYQRTSICLPLSIQSNVDRIYIVFGLSISALCFVGMVVNYILINFMIRNPGGPAKKQDAQIFRRSLALIVTNMVCWVPVLFFGITASLGYPLITITNAKICLVLFYPINSCANPYLYVFLTQMGHEAKKKAVINLKRHSGDKSFSSKFYYAHPPGDREHLRHGEEEANRNMSFLQVTQTTSLNSTPRGSSSSDGTKRSSMDPTDLPDDRKKSFQEQVITHASDSHLKRKSIAPRVSAQPELSEISEHSTNSGEDSEKAVTRTPTFFLEQIKSALFLRRQPSVIHLEMLEIPEEAPMELPQKRENSVISLGQDSGKGESIPRNSISSNETQEDKHRKFSVHSSVIQKSHLHRKRSDHKPETPALVLSEYLSFDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2R2</accession>
    <name>A0A914Y2R2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2R2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1353.t1">
        <property type="protein sequence ID" value="PSU_v2.g1353.t1"/>
        <property type="gene ID" value="PSU_v2.g1353"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g21160.t1">
        <property type="protein sequence ID" value="PSU_v2.g21160.t1"/>
        <property type="gene ID" value="PSU_v2.g21160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1353.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21160.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11083" checksum="A24966AD04573BDC" modified="2023-02-22" version="1">MKISHHLVDQLQNRQSLREREKVSLNNFLSKPLPKDFETNSVPIGAVIETEKLKYKVLKKLGAGGCGETFVVQNLSTKKELCAKVEFLNKEDQRLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3N9</accession>
    <name>A0A914Y3N9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3N9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14056.t1">
        <property type="protein sequence ID" value="PSU_v2.g14056.t1"/>
        <property type="gene ID" value="PSU_v2.g14056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF442">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14056.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31860" checksum="C06BE6309E72C698" modified="2023-02-22" version="1">MTFTKGKKDINCNDGHSTPCDLWSKNTIRLQIAFLLSFAMAICGLLRGHLGMALVCMMKIDQNASHYVYDDSYTSSLQVEWSLSNVGQIHTAFYIGTFVSVLIAHNLAQKIGAKATITAGIILNIISTWFFPTVVYFLPDYYYTAALRFVMGLGQGVFIPCASLLIAKWFPMHEKSTAMAIFSMGNQVGLALAMFATAELCKVRYLDGWPTSFFLYGLMGAVFIGVWLPNVKNKPRESRWISSAELMHIEESEQRLRAMSVNLNVPYRTLFFHFVNHLLWFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3W6</accession>
    <name>A0A914Y3W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3W6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13473.t1">
        <property type="protein sequence ID" value="PSU_v2.g13473.t1"/>
        <property type="gene ID" value="PSU_v2.g13473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01214">
        <property type="entry name" value="PTB_FAM43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033930">
        <property type="entry name" value="FAM43A/B_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF2">
        <property type="entry name" value="FI05246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="26"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13473.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27536" checksum="138CF65623B36E63" modified="2023-02-22" version="1">MPSLSPSQSRDFFTMPFRKRKYTINPPDDIYNVIYLGNVLTIMGKGEQSIEKPLALIWKAYCSKQQRHELSMKLMVTRSGLKAETKLQGLTEYWAHRITFCSAPTDYPKVFCWVYKHDGKKMKPELRCHAVLCKKATIPAQIASNLNDFLHQALQEYKREKRCIEKARKVSAQAGGHGLGPRRKLLLQSGSLNFRPPVSRSKSAPRLGSIDEEDEIVDEYVCNEIIMEVCFYFHFLTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y548</accession>
    <name>A0A914Y548_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
            <location evidence="2 10">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y548"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1456.t1">
        <property type="protein sequence ID" value="PSU_v2.g1456.t1"/>
        <property type="gene ID" value="PSU_v2.g1456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1456.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13492" checksum="859FF2DCE8831D32" modified="2023-02-22" version="1">MSKFMKKAFIADADVNEAEVIHATVDIELLQEACDVSWLALTKYRSEGEMARYIKQCFDRNHGASWQCIVGKTFGSYVSVDSKFFVHIHIGRTAILLYKTYAKGEYEKIADCLEDRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y603</accession>
    <name>A0A914Y603_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA-capping enzyme</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">mRNA 5'-triphosphate monophosphatase</fullName>
                <ecNumber evidence="12">3.6.1.74</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">mRNA 5'-phosphatase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">mRNA guanylyltransferase</fullName>
                <ecNumber evidence="12">2.7.7.50</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">GTP--RNA guanylyltransferase</fullName>
                <shortName evidence="12">GTase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="12"/>
    <dbReference type="EC" id="2.7.7.50" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y603"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:mRNA guanylyltransferase activity"/>
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        <property type="term" value="F:phosphoprotein phosphatase activity"/>
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        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
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        <property type="term" value="P:7-methylguanosine mRNA capping"/>
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            <begin position="81"/>
            <end position="232"/>
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            <end position="221"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    </evidence>
    <sequence length="304" mass="35350" checksum="C90083BD66723EAB" modified="2023-02-22" version="1">MECEIAADWIIDEKTLSEAEEYEYIESPRIQTTIPGVGYYIRIHPNENHDVYFHLRVNTNTNVDADYTFSIPSADFSLNKHSTYECDYIDENEVYAFSRKSLFESKNKYFRNGKLTFQLRGTLKCELCLIEQESLAQIFFKKEDKDFVIQVDDKEIKAHKLILRERSPVFAAMFDSGMKEAQESKVKIEGFSYDTVQMAINSCYDMEKLWYSTNDLLLLLKFSDVYDIAHFKNSVQQRLVMKLAPDNVCSIAHASVETNADKLRLCCMNYLLKCLKDSTAVSDLDFLDTEFKLELVTKAFCHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6Q6</accession>
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        </recommendedName>
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        <scope>IDENTIFICATION</scope>
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            <begin position="1"/>
            <end position="19"/>
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            <begin position="20"/>
            <end position="158"/>
        </location>
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            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14940.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18444" checksum="FB453293C8E4FAF9" modified="2023-02-22" version="1">MHQFWILMILLLWIPEITKIYLCYPEVGHTHDDADRYFSCLALPLRRKPVYSPFHFQRFLGQHLRGVVTNTLTSPVYDFDAVLEKNVIRNENLKSNHFFELSTDANNDAVKVIHPAEVFQNIPDPDNINLTAFLNDPKVWKTWHRPTPNVELPNGAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6W6</accession>
    <name>A0A914Y6W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6W6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15193.t1">
        <property type="protein sequence ID" value="PSU_v2.g15193.t1"/>
        <property type="gene ID" value="PSU_v2.g15193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15193.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31831" checksum="0EFBEB7936677B41" modified="2023-02-22" version="1">MGSDGTIIWEPELQTKCEYVQWKTIEGDLSKDIWVSRDRELALTFKAMTKVQDCNSTFIVSDQGYAILSYQFEETKLSNNSRSKREAPGIVLSNQLAGQLTAGQENALKVTKEYFKSALYHICQNSDTLADAIKSLASANPTLLARQLLENPNIQARLITESLLEVTPCEELNMTQVHFTPLQHCFDKMPVKFEYYDNTLTLHGFMDPVTGVVSSKATEVDCNTHSHFYIEQSDGKIKQINQKTGHVEYVKEAEKLNFKSAKLQYIKDEHRYLKILSSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6X9</accession>
    <name>A0A914Y6X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA2/NAM7 helicase helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6X9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15022.t1">
        <property type="protein sequence ID" value="PSU_v2.g15022.t1"/>
        <property type="gene ID" value="PSU_v2.g15022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15022.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10609" checksum="F06F98FB1A73DADC" modified="2023-02-22" version="1">MDESQYNALIYTLISELAILQGPPGTGKTYMGLQIAKLLFDNWSIWNSDAKESRPMLVVCYTNHALDQFLEGISKFVPEGIIRVGGRCKNETVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7A9</accession>
    <name>A0A914Y7A9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7A9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13511.t1">
        <property type="protein sequence ID" value="PSU_v2.g13511.t1"/>
        <property type="gene ID" value="PSU_v2.g13511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13511.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="12896" checksum="9DF690E531083DA1" modified="2023-02-22" version="1">MIVVVGPGVVVVMEPVYGVVGIGVVVGVHVIPQSVISLEAICDETVSTILASVISGIRKLYPAPEDKLAKFVRDAFPIPIVIILDPLVFKFSQNPWESETSESRLAIITIVFSTGAGRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7J3</accession>
    <name>A0A914Y7J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="4">Cell wall biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7J3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13585.t1">
        <property type="protein sequence ID" value="PSU_v2.g13585.t1"/>
        <property type="gene ID" value="PSU_v2.g13585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016803">
        <property type="term" value="F:ether hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1080:FF:000001">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000014">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00274">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003915">
        <property type="entry name" value="PRK05441.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009222">
        <property type="entry name" value="PRK12570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF4">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22645">
        <property type="entry name" value="GKRP_SIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="5">
        <location>
            <begin position="66"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13585.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34001" checksum="19E248A45744736A" modified="2023-02-22" version="1">MAKDSNFNLAEMKKTLPMTENRNSFTMNIDELDTVGILRKINQEDQKVAEAVEKELEYIAAGVDIVTEAFRNGGRLIYIGAGTSGRLGILDASECPPTYGVQKGMVIGLIAGGKKAIEEPVEGAEDTPEFAVEDLKEINFSAKDVLTGIAACGNTPYVIGGLKYAKSIGAKTIAIACSKDSSIGNIADIKIEVIVGPEVVTGSTRMKAGTAQKLVLNMITTSSMIKLGKVYGNLMIDVQAWNKKLVERCKRIWMECTDGSYEEACKYLDETNFNVKEAILMKLAEISHQEAQQRLKASNGHFKTALKMDLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y881</accession>
    <name>A0A914Y881_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y881"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1496.t1">
        <property type="protein sequence ID" value="PSU_v2.g1496.t1"/>
        <property type="gene ID" value="PSU_v2.g1496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1496.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="28349" checksum="7C10855A1192D7DA" modified="2023-02-22" version="1">MHAQTFRKDIPKQAQSSPADQKPDVHIILFDSVSHSQFIRSMPKTSHFLKEFYESISFRYLNKIGLNSRPNGHALLMGKSVFPIAESPVSRGYKTDYPNESWCEEYLDEDQFIGYRFQDAGYISMMSEDWAYGVFNWPNCWGFNHKPVDHYMRPFQIRVEGYYDQSPDMASKVYNGTCHEEFHHQMEYLKDFLRVYPDIPKFSITWMSYLAHNDANGLFHSDDYFYNFFKDYKDKVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8M1</accession>
    <name>A0A914Y8M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8M1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16543.t1">
        <property type="protein sequence ID" value="PSU_v2.g16543.t1"/>
        <property type="gene ID" value="PSU_v2.g16543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16543.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8720" checksum="A0D3A53D5ED3D522" modified="2023-02-22" version="1">MNEWKEAFQENFPQEDENKKQSSSTDIVEDKKFAEYEIDIAVEEKRRELEMFIREKKNRKALAEKSHRQNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8S9</accession>
    <name>A0A914Y8S9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YitH acetyltransferase (GNAT) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8S9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13986.t1">
        <property type="protein sequence ID" value="PSU_v2.g13986.t1"/>
        <property type="gene ID" value="PSU_v2.g13986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH/HolE_GNAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47408">
        <property type="entry name" value="PROTEIN CBG01304-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YitH/HolE acetyltransferase (GNAT)" evidence="1">
        <location>
            <begin position="56"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13986.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21391" checksum="C139C5A57326E7CE" modified="2023-02-22" version="1">MLGFNKYPDWQYEDMEADTKEINHENLEKNRLVKTISFESVDFKEFVCYDSHITGGIRRDGFIKRFMESKDAFSKVATDCDGKIVGYGNIRVGSNKQLAIGPLYADSGDIAETLLKDILKSINHITQYNKIFYYPSTSNNHAKEIFFKLASNKVRENDKMFVQFSDTIPKISAGKIFSITEYGLGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9A5</accession>
    <name>A0A914Y9A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9A5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14127.t1">
        <property type="protein sequence ID" value="PSU_v2.g14127.t1"/>
        <property type="gene ID" value="PSU_v2.g14127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF330">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14127.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27763" checksum="A91A454AD0284D41" modified="2023-02-22" version="1">MNAFMVWSRGQRKKMASENPKMHNSEISKRLGMEWKQLSEQEKRPFIDEAKRLRSVHMKEHPDYKYRPRRKPKNCMNGSIINNNNNTNSNHTMANHHMPKFHQSNNGKFSFGADSLISSLPQLANLGMPNSAGQNVPVTAATAAAALLRAANPAAAYLAAAAKLGPNDFTSGNGVSGLDFSYYPPLFSSALQHHHQQQQQHQQSQQQQQQQQQHQAAADFQRQLFAAYALNLSRASALSPNGVSTVSNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA03</accession>
    <name>A0A914YA03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 33B</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA03"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14353.t1">
        <property type="protein sequence ID" value="PSU_v2.g14353.t1"/>
        <property type="gene ID" value="PSU_v2.g14353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14353.t1"/>
        </source>
    </evidence>
    <sequence length="596" mass="67508" checksum="4C4DD328D6A4A3B2" modified="2023-02-22" version="1">MDDFDDFAMVTQLTRRELIHVLESIIGTKELVVEQSLMRPLDKVASMSFLKEHNCLRVQQLYLDRLISWDPNLENRVFLIRPSLTNVRKVCELIKAEPNVQYSAIFVDRKQNICDLEFEKQGVYGNIESYELNLSFIPLESDLFSLELPADIPRSSRTDYQAMARCLWQLQSLYGAIPNQFAIGQAAVDCQKVFQRICQDMKEPAATANQPISHLFLFDRSIDVVSVLLTGLTYESMLNDVFKYSCGKIVFGEAVETKLKQKSEGKKVIPLNNSDAIFSVVRNRHMSQVFPFLSARAKTLQESFDKASAMNKVEEVKDFISNQLRQLKQNHKLLELHICACEVLLETSKGSDRFGIEHAIVRREADANIVMEHLELAICKQQNPWAVLQLACLWSICEDGLLSKHFHAFRNLFLHACGYDYLTVFYYLQSNGLLIEKSTPSAKTSIGGASFKINSNFKELSRKTSFSHLTKSLRLTPASDIPFDPKSINPNPSYVFSDAYTPIACQIVSQTVADGWSTSKLQKVFGPEIPITSSLNPVKPDNRIKKALLVSFIGGVTFAEVAALRQFAQNSNFRIIVVASHVLNREEFLKSFIEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA36</accession>
    <name>A0A914YA36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14382.t1">
        <property type="protein sequence ID" value="PSU_v2.g14382.t1"/>
        <property type="gene ID" value="PSU_v2.g14382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053326">
        <property type="entry name" value="GPCR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14382.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27155" checksum="7B8878B37FF88069" modified="2023-02-22" version="1">MCADSFRTYSPFVNNFLSPLIPKLVPIAVIFQMCSVYITVLAAIDCYFSVSSFKIRHRWCQAKFATILVICTIIVIIAYNFISFFELQYSECFDPLERRIRYEICPTEFRTDFYVQVYKGYMYLVTMAILPCILLVGLCIGIFRNMQRRTWSDIFHADATNRFLLQNTLIRTYSIQTLMEKSKSRDQKSGSSPLMLVVVIILFLLCNSVSLIVNCLEILTGDTFAELNVSKFCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA63</accession>
    <name>A0A914YA63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA63"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16174.t1">
        <property type="protein sequence ID" value="PSU_v2.g16174.t1"/>
        <property type="gene ID" value="PSU_v2.g16174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16174.t1"/>
        </source>
    </evidence>
    <sequence length="344" mass="40352" checksum="A35C1E1E6F0691E5" modified="2023-02-22" version="1">MDQNFEMKLCEALRAIGINIDQCYTVIVENMADKENISKLIKSYENIKYFLMIADKPHFNAVMKSIKYETNINGNYKDFDKIRNMFDLCLEINRQCRGINYKCPKNFPISTAFCHFIITDKQISCGTNATKVRDPHIFVPWGDRGEIDLIAMLDRLCCKLTHILQNGFLFQDKYFKTLIITFENYLTTTLSDEIAEIIYETVIKWMAFVKIGIAEVTLEAPFQASENRIKSCLALKYEEELDSEQILKLMELCRFCNDLRLKADEITDLPEHIKIAHIHYSNIIRNYNDFKMLIENDNDSLDPDDDDFIVPVFDYPKIMLRNHTFMTDENDISLYSVDWSKKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAJ0</accession>
    <name>A0A914YAJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAJ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16299.t1">
        <property type="protein sequence ID" value="PSU_v2.g16299.t1"/>
        <property type="gene ID" value="PSU_v2.g16299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16299.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24096" checksum="345E4050C6045D44" modified="2023-02-22" version="1">MHLSDCDPENQERFALAVTKDENFVRPKCSFKIRKNLEVMKSKDFIQNFRMFRDFEYDRKPKPLPQSEEKTEIDLIKERREKLRNMTTARRTNDIPAYILDGIAESLFADEKEDVETMEFIKGIRVPITSLVEEFLAEKKRKEKEENDEEMLESEKNDESTTPTTALSMEIDEPTAAKPIEEEKVPTVEGEEKVPTVEEEEDAQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB64</accession>
    <name>A0A914YB64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S3</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16000.t1">
        <property type="protein sequence ID" value="PSU_v2.g16000.t1"/>
        <property type="gene ID" value="PSU_v2.g16000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16000.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24511" checksum="3C7AB3F8D5966CD5" modified="2023-02-22" version="1">MGDVNTIRNIRKSIPASLAFKNSQIEKPSDIYKPDFIKLEKAHIFCNESTVSTSPKSVVSVNSNISNKKTIRIPVLIKPPFLYRNHAAYKILSINGTIKDIKDVVSVETRMECIRIRKMCRRKPQNGSKLENSIVRIKKRILEEFHSEGKWAKDILVFEFFKIVSNVDVFKKAYCDIFICGVLNGVTRAKRERERMGGKSGRRTALTTIIELCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBD5</accession>
    <name>A0A914YBD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBD5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16590.t1">
        <property type="protein sequence ID" value="PSU_v2.g16590.t1"/>
        <property type="gene ID" value="PSU_v2.g16590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16590.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="30494" checksum="09CB903FB886250D" modified="2023-02-22" version="1">MGLKTDSLPTNSRSKMNPRDLKIKQIVETTRCTHSEAEEALQENNNELEAAVSWILDHTGDNVWTESKTRKAKKTDVVVEEQRPERPPRGESGNRRGGKRGGGTTRVASNNWKPGQVFTRSEPPAKSTSPEDSNFFAPNSNNGSVVPNVSLNSNSATAPSSANNGPLASVSVTPAPVMKNAAGPMSFAAICALGGKKPTPPPVVPPPSSSAAPKPVSPATTPLKPVQSPQVATPSTAKESSPAPHETPVKSSPSVSKPEPITPEPASERFTENNTVQSLTSQLKFLIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBQ9</accession>
    <name>A0A914YBQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g14916.t1">
        <property type="protein sequence ID" value="PSU_v2.g14916.t1"/>
        <property type="gene ID" value="PSU_v2.g14916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000933">
        <property type="entry name" value="ABC transporter A family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001598">
        <property type="entry name" value="ABC transporter ced-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1026"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1069"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1134"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1164"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1206"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="505"/>
            <end position="736"/>
        </location>
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        <location>
            <begin position="1274"/>
            <end position="1498"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14916.t1"/>
        </source>
    </evidence>
    <sequence length="1611" mass="180731" checksum="8AAF5AA34667F345" modified="2023-02-22" version="1">MTFLKHVWILTQKNFHMIKRSKIWFLFELGFAFLLLPLFIFIVSKSSTDITPSRQFGSVRITGDREDLMRNVNNVNRISSRMCNAKKLLGYVTTNNIGDEIMNEFANRYNHYKVPVNVAKFNTLDEMKTTLLEDLNATMSKVCGKYMGGVHILEVDVHEKLFKYRIYVRDRGGADWETTEFWPPEGPYGTLADLNEIPGKPGYWSSGFLSFQFSLDKIFLEKVGKNTTMEVFLWRLPTPKFRNNGLLAILTTMPILFIFLVIIIMIHTTKEIVAEKEAGIKTHLMVMGLHSASFYASHFLTALIKVLIVVGICTTVLSLGFDSISPSVFVVFCILFGIAAVLFSILISVLCRRTSTAVAAVVLIFIGLFILDTYLKVSPTRIGTCIVASLNVFTAFHLGLLAMSSYESRLINLTWFKLFAESTTSFSIGAAFLMLIIDCLIFGFLIYYLDAVWPTDDAPKKSPLFIFPFIHTKGVGQKVDLDAASNNYSENCETDGGVGRDEADIAIQNMSKVWETGQVAVDGLSLNAYRGQVTVLLGHNGAGKSTTFSVISGVCSSTHGEVFICKKSISKNLEECQKEIGYCPQTNPLFAKLTVEEHLRLYGKLKADVWDARSEEKLKDIIAANQLSEKSHELAESLSGGMKRKLCVAMALVGDSKVVLLDEPTAGMDPEARHEICKMLEREKKKRTILLTTHYMDEADLLGDQIAIMVKGRLVCKGSPEYLKNRFGTGYILTLVIEPNQQLPEDKTEILEGIRRRLLKVVQKQAPNAELESSFGLHFANMFEELEAEKTNLQISSFGLSFNTLEQVFLKVGEIAEAQGDHVDGQTMSKSEAFFQNDETQYSKPVQIMKQIGAVFVRYAIGAYRNKVRTLLPLIVAVVCFSLVAFFQNQTGKLQKRDLNLLKQEPFTIPLQFNQEQPIFVDFPYIAGKLPGGVPLTVSPHDNFTKMVMKHSYDSPALGIGAYVAPNGSVFALFNGAAFHGPPLAMSFLSNSILQERADSIQTSVEVYSSDLVSDVKNVVSPVATIFVNILTILCFSFFTCMFVMPLVEDRVSNFKHQLLLTNLNRFTYWLAVTLWNIAIYLIFCLILATILFISGWMEACMNTNFVFWALFFWSSVPFVYVSSFIFTSPVKAFVALLCWNVVGGIVASVATQIVNLLGSSDLATALTTLFSIILPSFALGHGVMEVTMQCPVLGKIVRWDTLQKVMVCMTASGFVFWILLILCENTMEQIIFSLRKRFNRGKYEAVNTQESEDEDVRNERVRMNQLSDDRLALSVRDVSKYYDNFCALRNLTFGVNPTDCFGLLGINGAGKTTTFDILTGRKFASNGYAYVKGVDIRKMPAIGYCPQFDALALDLTGRQILTLVGHLNGFIDVPRRVESVLESIHMEPQADKLVLHYSGGQKRRLSIGVTLMSRASLIMLDEPTAGIDPKTRRHIWNLLSAVRERKEVAILLTSHSMDECEALCSRIGFLNKGSLISIGTSQHLKSRYGNSFLLTFTIENPNKHNRDYLNREVMKNFTGVVPTQDLEYMNTYHWDIPRESNNDSWSSLYKKAQEISLKYNKNEDFGRELPVIKDFSVTQNSLEQVFLRLTQLGASLDERHGAHTLGHLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBU6</accession>
    <name>A0A914YBU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBU6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16232.t1">
        <property type="protein sequence ID" value="PSU_v2.g16232.t1"/>
        <property type="gene ID" value="PSU_v2.g16232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16232.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="36721" checksum="8D7BD8467301D1BA" modified="2023-02-22" version="1">MDGNQNGSSLEVIYDQIEEICDELDAEIISAEKLLNFVQYLKAVWNETFSNILLHPWTEPKKLTNFLRIIVAFKHNYASEERHTLLEVFDKILKSDLLKTIIAENISIMAEIKMKDRIRAKLFHYLIEILLFGYENHLTKMDDYESDVHKIISALKFKDVFLEMTKEKFAQLEKIYIDLQNLESQKAKKKAKVPFRNRIFTGNKGLPPENYRFLSLIPSPEELKINFQPYLRSAKIDEPYFDSEHYLDVHFRLLREDLISPLRSGIEEIKTGKTRMHLYKSVKFLELALHLPSGEYIHYVKIHVCSFLYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCQ7</accession>
    <name>A0A914YCQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCQ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18022.t1">
        <property type="protein sequence ID" value="PSU_v2.g18022.t1"/>
        <property type="gene ID" value="PSU_v2.g18022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18022.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9865" checksum="4707C7407C157207" modified="2023-02-22" version="1">MLSLVTSKIFFADIDGNGQIEFPEFCVMMKRMMKETDSEMIREAFRVFDKDGNGVITAQEFRYFMVHMGMQFSEDEVDEMINEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCS1</accession>
    <name>A0A914YCS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17085.t1">
        <property type="protein sequence ID" value="PSU_v2.g17085.t1"/>
        <property type="gene ID" value="PSU_v2.g17085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057130">
        <property type="entry name" value="Myosin_VII_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24123">
        <property type="entry name" value="Myosin_VII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 5" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17085.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12192" checksum="9EF522364B7AC59C" modified="2023-02-22" version="1">MTQLGDFIWIEPVIKGQYGAPIGARVISSEAGKILIVDDQGNEQWLSSERRIRIMHPTSIQGVEDMIQLGDLHEAGILRNLFVRYKEKLIYVCFFILLIMVIKIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCV4</accession>
    <name>A0A914YCV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15295.t1">
        <property type="protein sequence ID" value="PSU_v2.g15295.t1"/>
        <property type="gene ID" value="PSU_v2.g15295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15295.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26015" checksum="F316D447D9C336AD" modified="2023-02-22" version="1">MDECCGFDIYDCTQPSTQPSTEDFFRLSSRLYKSADQLSLDDRMNLLPVLEDLVSKFEDCFMLKNLVRSIRRFIDEEILPYKGLYYKELPYKACLESDDGDEEQEYMDDFEFVDDDDDGHGATHDELFVPLRKGSPLRFDGLSVVSECDSETFDDGATSYTDEHESMQESTFVNDLKQDKVEVLGRIPELAFKKLSFDDVCNKKSVKRSVRNAVRRVSSAVRNAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDM6</accession>
    <name>A0A914YDM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18325.t1">
        <property type="protein sequence ID" value="PSU_v2.g18325.t1"/>
        <property type="gene ID" value="PSU_v2.g18325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18325.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17717" checksum="36512B95CE18C37F" modified="2023-02-22" version="1">MEMLKLAVKLGKELKSYLSLAQNFKSYSLKRELFNLVYEWSIFGGAEGVDLETFLKKAKQGYENNYQQWNLLIAGVEKRFIENNYEIFDDDDAQLASLQRSIDPNFCSRPPQLRRTRQSKSVAKSASPNFEVNIDGEIQEHPDAPVGANISPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEM2</accession>
    <name>A0A914YEM2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(+) ADP-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YEM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17906.t1">
        <property type="protein sequence ID" value="PSU_v2.g17906.t1"/>
        <property type="gene ID" value="PSU_v2.g17906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP alpha-helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17906.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23662" checksum="B8F0D8B7B2E9A973" modified="2023-02-22" version="1">MSATTSSSTTTTMPSTSAIEFKTVPSFSSINNNEEMLEENENESVKVLNVKCDAEIAEIIEDPEIVAVKIRENVELPKPLHNLIQRIFDPNALISALKGMKLDLEKLSLEQITQDQIAAARRILKDLAQELRHGLKEEHVKEATAEFYSLIPHVKTLDDHELPLLNNPRIIDSKASMLNTLADIEIANRSIGDIILQHEYIDRKDKQIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEN5</accession>
    <name>A0A914YEN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tagaturonate reductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17217.t1">
        <property type="protein sequence ID" value="PSU_v2.g17217.t1"/>
        <property type="gene ID" value="PSU_v2.g17217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009026">
        <property type="term" value="F:tagaturonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019698">
        <property type="term" value="P:D-galacturonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="165"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="268"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17217.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40422" checksum="572FEC1CDB65A80C" modified="2023-02-22" version="1">MAEKIRKGVELQPFTWTKTLYLTFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPPSLSTQDGLYTTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSNTTEAGISYHAGDKFDDAPAGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAGLDTVGEAMNDAEICAFVEKAIYEEIIPVLDLPRDELESFATAVYRAQRYDQVPHPHPATAAGRAEGKRHTSGAPTFALAALIAFYRGERNGETYPVQDDAHWLERYQQLWSQHRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLDAILEKGMREAVRPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEV8</accession>
    <name>A0A914YEV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17994.t1">
        <property type="protein sequence ID" value="PSU_v2.g17994.t1"/>
        <property type="gene ID" value="PSU_v2.g17994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17994.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15651" checksum="4BAFB920CA3A4D78" modified="2023-02-22" version="1">MDHTDENEEIEQLLEKEKEVKKDGKITTKKPTFEELIEQIADLGLNGFSGAPLAKRPRFTLGDDEDDEKPVKPLLKKHQTHKQALREELMISYGDILIPVNEVTDEMLEKMSKEELEKVCEAREKLLDLLFRCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF23</accession>
    <name>A0A914YF23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF23"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15979.t1">
        <property type="protein sequence ID" value="PSU_v2.g15979.t1"/>
        <property type="gene ID" value="PSU_v2.g15979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="106"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15979.t1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58456" checksum="1A305D260095F0BA" modified="2023-02-22" version="1">MSKITSYFALKRKSPEFGDDDIADIVGKKLNRTEAYGVIQNHWRPNDGYTFQSKLIGGKNRKPQLSWFKEFPSMTYSKKENGIFCVHCVLFVTGAVGKGQHQIPKSFVSKPFVNWKDFKEQANNHLKHAYHKDAIQIVSSFSSNFSSVVSKMDGQAKTAETNARKQLLSIIKCLKFCSTKRLPLRGTDDNQPFTMKDDPSEGVLRGLLKLIGPSDEGVKCLLDAPRNAQYISGTIQNEVIHIMAKEVLKQVVEDINSAKCFALLADETGTHSKEFLSICIRFVDQKTMQIREEFIGFYHAKEVTGEALASYLLQRLPALGIDMGKMVAQGYDGAANMCGKDKGVSTRIQKIYKAADYYHCPNHGLNLVMNKASEIIHIKNVIDMAKDCAVYFRAAVKTPVLAKHADILYKKRKDGLDANSRSKKKTIPKFCATRFVERHESILTMKELFPAVIDALEELVEARNDADAQKFLDYFYSADKAFALIVAEAVARPLKSLSEVLQQTTLELLSAFEYIENVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFL4</accession>
    <name>A0A914YFL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19093.t1">
        <property type="protein sequence ID" value="PSU_v2.g19093.t1"/>
        <property type="gene ID" value="PSU_v2.g19093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19093.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12262" checksum="7FF8E5644234D295" modified="2023-02-22" version="1">MKLNSDRIHRFAESTCREDWDTFLCRVKRTPINSHQFLSYNGTEKPKNSDEINHILIIRGDKQPNKLRACSRGCTFTDISHSNNITIETELQGDPTLQTQVTQPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFM3</accession>
    <name>A0A914YFM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1616.t1">
        <property type="protein sequence ID" value="PSU_v2.g1616.t1"/>
        <property type="gene ID" value="PSU_v2.g1616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1616.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15521" checksum="D8EB5115BBA36D08" modified="2023-02-22" version="1">MEVNLYRKLCHNLHKDTDFPVYDIDSPAMYKACVDRMYAATKAEQLEHRITKLTSKRAWENKAAEEAEIVLDKMTDEEQEVLHSYHREKKAALNALKVLLRQPFGKNTVAATTPGAQPPLTQKNTTKLLRKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFW5</accession>
    <name>A0A914YFW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFW5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18342.t1">
        <property type="protein sequence ID" value="PSU_v2.g18342.t1"/>
        <property type="gene ID" value="PSU_v2.g18342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18342.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8870" checksum="406232C29E587DA0" modified="2023-02-22" version="1">MDRQDQQIPQLVIMVRYSEAFYSLIKLNIEELLAAKSFISQSLLEKFEESNIPVYTGSENPKSCIFVKKELHFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG10</accession>
    <name>A0A914YG10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YG10"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18389.t1">
        <property type="protein sequence ID" value="PSU_v2.g18389.t1"/>
        <property type="gene ID" value="PSU_v2.g18389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18389.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10733" checksum="579827F8A8264003" modified="2023-02-22" version="1">MINIYEGEDRLVQNNKLLGTFLLRNITPAPARIPIIDVISSIDENGIFTVTAVDQLSGNTNSIKIVPDKGRLTQNELIKMVDEICHPIIEMEIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGB0</accession>
    <name>A0A914YGB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19335.t1">
        <property type="protein sequence ID" value="PSU_v2.g19335.t1"/>
        <property type="gene ID" value="PSU_v2.g19335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19335.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32511" checksum="0DC02C9670363C0E" modified="2023-02-22" version="1">MQGHQAMIAAVTAPGKERTTAFGKVGVCFGISFVIAPIINKVAGLFFHDSASLFSAMILSFFGVYVAHKYVNDDEFASYKEDKKDNKEESKVSFQKVIKIAKEPNVLTVFLQKNIAVAPMHIPFAVMQLYLIEKFNVTEGENSTIQIAIGLLIMLVNGFGISYLRNKFAEEKLIHLGALSLLLVHAQFSYFVYFYQLYFILPFLALGMTLVNTVSDSILTASVEQNEQAIILGICTAFASFFRTLAPSVGGLIMDKYGFSLIGYIGVICALLSLSVGFLFPIKNAKISDETKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH26</accession>
    <name>A0A914YH26_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein aurora borealis</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BORA family.</text>
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        <property type="protein sequence ID" value="PSU_v2.g18634.t1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Aurora_borealis_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14728">
        <property type="entry name" value="PROTEIN AURORA BOREALIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14728:SF2">
        <property type="entry name" value="PROTEIN AURORA BOREALIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15280">
        <property type="entry name" value="BORA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18634.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32931" checksum="6D2D232BFFDE8A78" modified="2023-02-22" version="1">MASDDSAYGRSNSSNDDSNHDANSTTSGNLNDLRSSRNITNPFDSHLIDSFHHTTFSPNTVLKTPATNKSKINTSFQWSIEQRSRILPAMIDESFIHESPDNPEYELQIQRTLDKYWSNKLIAPSPDVIGGRIQKPLNFTPSPIVPFSRRNSRLFDSNSSPISHTSVTCLTKDTQTDITIPIDFDLEELLSKHLPQKPTASTPKMKKFSSFLDKSSFNRDSLPTDADLDLVEDEQINFSVAMEESAKSRGDLGTSFITEHIHVECEFDLSKISPIKLEMISPHTRLSPIKEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIV3</accession>
    <name>A0A914YIV3_9BILA</name>
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        <submittedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g20262.t1"/>
        <property type="gene ID" value="PSU_v2.g20262"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20262.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="14107" checksum="4DC6C7334CFD22A4" modified="2023-02-22" version="1">MERMRVNFPHYHGIEENLGNLRSIVQVMDPELFELMMSNADFTHLYFAYRWFLLDFKRELTYENVFKLWEVIMAAEHSVSPHFQLFFALAMLTQYRHIVIENNMDFTDIIKFYNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ36</accession>
    <name>A0A914YJ36_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g18847"/>
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    </dbReference>
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            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18847.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22507" checksum="2BD88AB0540EBB8A" modified="2023-02-22" version="1">MNFYTYIKFTVSRSPPVVYDEIIEDDITKDVDKPEDTQSPSKSPSVHSETIVDAINTKPSNINMTTPENNRTSAKTKLASIRRSQNIEPHQTSSSSSWQNDNLPERMPYQSWSHKYYDLQDPFHLPPDLPIDKPAIIHSDRLFDDEHEMIFARESSTESVLPSPSTSLDSTISEESFEKSLPEKKQQGFFGNFCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ57</accession>
    <name>A0A914YJ57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g19542"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Urease, subunit C, domain 1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19542.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10326" checksum="6A925C7DE7B98A77" modified="2023-02-22" version="1">MMSYTLWTDLRLAPTADPEYVIEDACLVVQADRIAWMGPRHDLPAQWQDATQEHKLGNRWVTPRADRLPHPSGLRRQPRPGICLAAGRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJL8</accession>
    <name>A0A914YJL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJL8"/>
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        <property type="protein sequence ID" value="PSU_v2.g20530.t1"/>
        <property type="gene ID" value="PSU_v2.g20530"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20530.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="20322" checksum="49254788785C25B5" modified="2023-02-22" version="1">MTHVHRYLMSTQNGYTAKLIKFCPTFRTLRLTWTAFSPKSAGMDEFVDEYLPVIRENNPQIRYFLERSHKDWDPWVIGEYEWTRYRKRRVVSKTKDQILALIEEMSIGGDYRSGQKRRVQTRLPRGQELWDTETMGHDIFKVYSKWKADPEDPDAITVEAHPHFVHRKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJP9</accession>
    <name>A0A914YJP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19749.t1">
        <property type="protein sequence ID" value="PSU_v2.g19749.t1"/>
        <property type="gene ID" value="PSU_v2.g19749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19749.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15351" checksum="F725659A61395B0E" modified="2023-02-22" version="1">MDRTFLQVRFIVYSDSGAIVPVALMTAMFALTATAIEVKGVVTAATVLTNPDGKLTIDPSKEMEQKARDRIPGYAYVTSMKVMKDDHVRWYDMEGLSESAHLRDAFKKAAEAASLQYSQVAKMVQQLTERGKNVEGMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKB9</accession>
    <name>A0A914YKB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VP2</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19785.t1">
        <property type="protein sequence ID" value="PSU_v2.g19785.t1"/>
        <property type="gene ID" value="PSU_v2.g19785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19785.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="15583" checksum="A161527987060EF1" modified="2023-02-22" version="1">MYCRDSRYQGFGNPQYQNKNNDQPDLLQGAMSSLSVGWSMLSKGATQAAGLAAQAASQAGAKAAELSSNINTNEGSLLGSLTSKASEVSKTSWGGLQNFVKSPSLQGFTGAFKGGQYEDIGSPNSSMHPQSSPSLSSQYHGEIDSYDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKL1</accession>
    <name>A0A914YKL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1988.t1">
        <property type="protein sequence ID" value="PSU_v2.g1988.t1"/>
        <property type="gene ID" value="PSU_v2.g1988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1988.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19563" checksum="33BD97B320EC54BF" modified="2023-02-22" version="1">MIWSNDNGEPPEFKGIWLNGRNGQTHFVPYWSPSVDPLCYPLLFPYGTQIYHNGMELKKVEDAKKVERKKVKKVMEEDTDVSDGDVDRHINGCDDDEEEKVDEDILEDDPSKKRTTKGRRFASRKQVTRYFLYQRQQKYHVGFQKPHWLWSKGPIADAWLIDMKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKX9</accession>
    <name>A0A914YKX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17981.t1">
        <property type="protein sequence ID" value="PSU_v2.g17981.t1"/>
        <property type="gene ID" value="PSU_v2.g17981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="2">
        <location>
            <begin position="94"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17981.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17366" checksum="40F4FB7959A3445A" modified="2023-02-22" version="1">MLPSTSPSSMGSLQPPIPPVNSPINASASNRIAMDPNGNPLETPSWSFGMSACFPSIYSLFWKQRTANSNSSDSDSDEYEISLESIKVNFKDDYIGGGTQSSVFRGILNEKTIALKKLNRASEVDIRMLKALEHPNVIRTLGVSTKDICPCIIMEYCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLV6</accession>
    <name>A0A914YLV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncoordinated protein 79</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLV6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21313.t1">
        <property type="protein sequence ID" value="PSU_v2.g21313.t1"/>
        <property type="gene ID" value="PSU_v2.g21313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14776">
        <property type="entry name" value="UNC-79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21313.t1"/>
        </source>
    </evidence>
    <sequence length="1086" mass="123264" checksum="EE3353B088186FAD" modified="2023-02-22" version="1">MTVLRFFQQTLIGFIKDLPTNTSTLFHKFTTDSQRTNLFPNLNYSGLFYGIVNLLDVFPLLQSGQKDIGQEIIATLKSLYFFLDRDCIDQLPYLIASQIGILPSELNKKLVSFLADCILPYSMSNEANGELSVPCILMLVLQQYGDPTLHTYIVESLMAHRSNVYNDIIAVIAKGTSEARVAAANLLFHYWPLMNPSILHRKPIQYKVHAWAPPTCEYGTCTNPSVKITYDPAVCAKYGNTSPPMRICKGCQNLMESDQPTFYICQPMPASNSTICQNKGCESTNRFAVGTCFSEDCIRSHQHVPLRLCQECFTHLHANINPTNHIRQDRKMCAWETIIERDMIEAIVKLLKETSCQLEGTEGEGKRPKWLRQLEGGQSLGRDIDSMADEKRMLSRYGIWLMAAMCPPSIEAPTHAVGYMMSMVFQWFTTTALLPNDSMGSSLEQLKTDFASEWVNQAINNHYDTFVLTLMPHVPEYAQVGGVWDKFCSRKDQLKEGLSKLLALMPYDVISFPTWNQVIPQWLKCISDEIDDEDFSELKILLCKIFEPDLCPLPFETEKVFEFILTRLMNGTYEEILDALDWLHMILTMFQGCLSRLSTVTLSSTQNENDLEENPGPLAIQVVMISIVSQQMKLNENNHQDSQTYPTQTEEHTCQNPETDQYSDCVRCQQAAFLYQIINNIAEELCPKDEVKIEFNASDRDNWLNDLQMTDSGTTPSHISNVTSPRNPSLHGTINSPQVAGVEQPLIQAQRGSFQYLTANVQEEIANDEFVGLLPTEEIETATAQATTLTETDVGRETCQIVTATLFESLKGTPLQPRENSKIEFWNTSVGRFRFSLDQLPAQLRLIYSLLQNIENEVDPDVQYFLLSTMKYLCLHCEALSNARREHRGFLIWVQENLLISKLWTLLRSDYAQVGQLAVPLLIHAITLPCGEEVFWNTVNHDFTSEKWEVRFKAVERVYVLAHLMVEAPVKANKLLQTSLSCAFSHLIVSVNDPNAAVAQRTLLALRALPSKCLNLMNLCLEAQFDSCILDRPLIISRVYLLTAVVPEENILTWEFFINRFETLAVEAQLKFQSNETGFVQGLIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLW8</accession>
    <name>A0A914YLW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLW8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21324.t1">
        <property type="protein sequence ID" value="PSU_v2.g21324.t1"/>
        <property type="gene ID" value="PSU_v2.g21324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21324.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19910" checksum="EBAE93FBD0CE183A" modified="2023-02-22" version="1">MTVTLVIVMFELTGSIDFVVPTMTAIMIAKWVGDATYPMGIYDAQIELNNFPFLDNKDNKEDGDSEIQDLLVRQRKTDQLIVIRQNGMTIHELEQILNETSYCGFPLLESLESKLLIGFCDRRNLELNLAEAVGIDFTTPIAFSSEVSSGRELRWLNAVDVVKNIPYTKLFTLNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM83</accession>
    <name>A0A914YM83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1352.t1">
        <property type="protein sequence ID" value="PSU_v2.g1352.t1"/>
        <property type="gene ID" value="PSU_v2.g1352"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g20685.t1">
        <property type="protein sequence ID" value="PSU_v2.g20685.t1"/>
        <property type="gene ID" value="PSU_v2.g20685"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g776.t1">
        <property type="protein sequence ID" value="PSU_v2.g776.t1"/>
        <property type="gene ID" value="PSU_v2.g776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1352.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20685.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g776.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7805" checksum="62C8E40FEE6CD336" modified="2023-02-22" version="1">MGEKPIYKYDEDGLPTLVDVHLVEPESPEPKTPAPRTSKSKTPSKSRDASPNRRRTPRKSKKSVDNEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YME5</accession>
    <name>A0A914YME5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YME5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18497.t1">
        <property type="protein sequence ID" value="PSU_v2.g18497.t1"/>
        <property type="gene ID" value="PSU_v2.g18497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18497.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8332" checksum="72259E08840ED4C2" modified="2023-02-22" version="1">MELDAMRILGLLDEQLEHFADETLNTFVARVLDSRAPHDNLIKFEAFPDNYSIVIKKNITKADKIDPLKIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNG3</accession>
    <name>A0A914YNG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18876.t1">
        <property type="protein sequence ID" value="PSU_v2.g18876.t1"/>
        <property type="gene ID" value="PSU_v2.g18876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18876.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12472" checksum="E2CEBA67C9D5EFED" modified="2023-02-22" version="1">MDAYQNNMMKIIHARPTNLANEVRKFTMQYFTKIQTPPHLLRQRALLMILLINELKKDPIYRSSVNKCLEEIFNCVITFLETQDEAYITTLNTIEFTSTDMIVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPG5</accession>
    <name>A0A914YPG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPG5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19249.t1">
        <property type="protein sequence ID" value="PSU_v2.g19249.t1"/>
        <property type="gene ID" value="PSU_v2.g19249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19249.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19831" checksum="97C69CECB6671EBE" modified="2023-02-22" version="1">MDKLDGPEPSNHAKTVQFKVLASDTKRINAKPAKIVKIEVPHDSKTELEAAINIIQKYLDQRLSKDEEPDQKLIDLLQEHERLRNGEKAEIDRAFGLYTAFWFIFAHNASLVANDDLDRIVIVLNVTMEDAVNGKKDEKPAPEPVAKPADVKRLKKVCLIYNFLHFFRLWITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPH2</accession>
    <name>A0A914YPH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2134.t1">
        <property type="protein sequence ID" value="PSU_v2.g2134.t1"/>
        <property type="gene ID" value="PSU_v2.g2134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2134.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15364" checksum="F608DDFD0AB1801F" modified="2023-02-22" version="1">MPTLRKALETSLKTDDSSTTTTTSSPMAQNGNGNVRSVCDRHPAVASLLSRPPLSTPSSKLSKMNNSSVIVKSECIDGISNSTNIDMKDDDIIITDKMIIKSELSENENNNDIVVDDDDDDEEDDEMPLNLCIRDNKISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPN0</accession>
    <name>A0A914YPN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPN0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2159.t1">
        <property type="protein sequence ID" value="PSU_v2.g2159.t1"/>
        <property type="gene ID" value="PSU_v2.g2159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AMOP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="6">
        <location>
            <begin position="112"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2159.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22054" checksum="021B12FA252965C7" modified="2023-02-22" version="1">MAVDPNFVVDPQCHDSSGCFYHPGAEICYFSAVPSPSGGGQQCCYQNRQIYLQRPGAGYPTILHPSIQAGFPHKAFEQYPLSMCCMVADKEDCDKYMKTRNPDDGSNYTAPTTSLGNGDPHYTTFDGLYYIFNGAGEFWLVKGSEKQPFSAQARHVVPSDDADYAYLMAYAFKPYPNASIIQVETNPLSTEIYHNRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQL0</accession>
    <name>A0A914YQL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2467.t1">
        <property type="protein sequence ID" value="PSU_v2.g2467.t1"/>
        <property type="gene ID" value="PSU_v2.g2467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2467.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14418" checksum="EBF98F7E3721D21D" modified="2023-02-22" version="1">MGTTALSLKFASPVPVNGLQAIVYSEFDSILMFDAGQRYNIMKNRTHDTGETKDLKKEIAATLKNQETQELIQRKNEYKEVHEEIPKTLDKKIPQVAVTLDQKSEKKKKTQAEKPKKPKKFVVKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQM1</accession>
    <name>A0A914YQM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQM1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19662.t1">
        <property type="protein sequence ID" value="PSU_v2.g19662.t1"/>
        <property type="gene ID" value="PSU_v2.g19662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19662.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21104" checksum="E33A432281ECF217" modified="2023-02-22" version="1">MYKKNCPQAKFVMFPFEKFPDRVKDLNNYIFKPLYIAMAMRNHKVLLSFDSSIFFVSNANITNLIQTAVKENPTDVSLLRTAYHSNFLTTHPKMYDCFPDIKPNDMQRVVQYNGGLVLWVGSEEGWTAMHRWVECALQPTCMAPLGATKTCDVKVKIHFFGYGLKASHLFGIRLHNATFLFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRE3</accession>
    <name>A0A914YRE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2749.t1">
        <property type="protein sequence ID" value="PSU_v2.g2749.t1"/>
        <property type="gene ID" value="PSU_v2.g2749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2749.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16678" checksum="370DA7B0E6969040" modified="2023-02-22" version="1">MKACVKSGTKDDGNITFFIERHVESPNPVERRRRQIEVTLNSSNEHAEPVDKCSEPKDEHPPRRKRGKYAAYIKKKELSSMAEVKQAASSAGLKYINTVNRTAYFMCSIDGCPYKSRAVLTDEFRYDVLETDLQHNHGTVERKDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRG7</accession>
    <name>A0A914YRG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CUT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRG7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2245.t1">
        <property type="protein sequence ID" value="PSU_v2.g2245.t1"/>
        <property type="gene ID" value="PSU_v2.g2245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000005">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051649">
        <property type="entry name" value="CUT_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057:SF47">
        <property type="entry name" value="HOMEOBOX PROTEIN ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057">
        <property type="entry name" value="TRANSCRIPTION FACTOR ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="9">
        <location>
            <begin position="304"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2245.t1"/>
        </source>
    </evidence>
    <sequence length="394" mass="43708" checksum="F4A8519CC1B8B942" modified="2023-02-22" version="1">MESLDNSDPMLCAVLDIHSPGAPLHVDEYRQLGENNLYHGRLSPHSGSIITTANPYNTNYATLTTMQTLPPISTVTSSSQEKYIIIQTNGIRSRSIEALSPPRRRINQHASLTHSDSALSDCSLSTSGQSSEISQYPQDTSNTNYYHTSCPPEPSPPSADSGTSSCGSSAYGSMMPAYNLNIKYEYDVKTEDETPCDIQHSSDNSEPSFNNSNNNENGQLNCAINNTATFIAVPFSSSSTCQNTHLIQPKVEKIVYTPCGAFDAYNGDLLDSVSILEEDKLRSPSPRKLQLSPLPNDFLSNDSPDSNDDLEELNTRELAQRISSELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMAKWLQEPEYQRMSALRLAEFPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRM5</accession>
    <name>A0A914YRM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">T-complex protein 1 subunit delta</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20041.t1">
        <property type="protein sequence ID" value="PSU_v2.g20041.t1"/>
        <property type="gene ID" value="PSU_v2.g20041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20041.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="27557" checksum="1D1197B2852A4447" modified="2023-02-22" version="1">MAPAVKSAPIAAPKSHGMGPKFTEKEKPASVRTSNICAAKSVADAVRTSLGPRGMDKMIQAADGEVTITNDGATILKQMSVIHPTARMLVELSKAQDIEAGDGTTSVVVMAGALLDAAEKMLNIGIHPTTISDSFQRAAAHAMQVLEEMSTPVDLENDEELIKLASTSLNSKVVSQHSWLLAPMAVKAVKRIIDVESPDNVNLNMIKLVKKLGETVEESELIDGALIEQKSMGHGGPSRIEKAKIGLIQFQISPPKTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRP2</accession>
    <name>A0A914YRP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRP2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g284.t1">
        <property type="protein sequence ID" value="PSU_v2.g284.t1"/>
        <property type="gene ID" value="PSU_v2.g284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g284.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10277" checksum="5F299411F787D5BC" modified="2023-02-22" version="1">MSTTSASEDTISSSSASSTGPTQVEKKEPLAVEAEDYVFDQYDKFYMAPPTAGLLHYRTAAIICGIAEVAVLIGATLTLVLEEHAFDILLPAGFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRX2</accession>
    <name>A0A914YRX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CASP-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRX2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2401.t1">
        <property type="protein sequence ID" value="PSU_v2.g2401.t1"/>
        <property type="gene ID" value="PSU_v2.g2401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2401.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15537" checksum="D4457C5C06D09BCB" modified="2023-02-22" version="1">MPFNGTTTNLSPGSLSQGGFGGDRFNTSRVCISLVNLVAAIILIAFIKKSNLQNETQKTVANLVKRVLLVQTFLDLAVHAIAFGASLVTKTSASTLLGPYARTFSALDGVICCICFAKAIQKIQKNKISVPLRTISFPSQVKITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS65</accession>
    <name>A0A914YS65_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914YS65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3014.t1">
        <property type="protein sequence ID" value="PSU_v2.g3014.t1"/>
        <property type="gene ID" value="PSU_v2.g3014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="15">
        <location>
            <begin position="6"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="158"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="433"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="17">
        <location>
            <begin position="541"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="12">
        <location>
            <begin position="655"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="1023"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3014.t1"/>
        </source>
    </evidence>
    <sequence length="1127" mass="127871" checksum="7B796DD1762AD9AD" modified="2023-02-22" version="1">MECEIASYHVESYNYLADTGIKAAALDVPAIKFRTVKNENYEINFSDAQLGKPSIGASKSSNLIDRIPIFPSECRQRGLTYRAPLTVDLKVKQDGVNAYNITFEAGEVPVMLKSNRCHLYGKEGDELIKQNEEPLEKGGYFICKGSEKIIRLLVCNRSNYPYAIVRNSYKGKGKFFTEFGIMMRSVREMHSAAVSVLHYLDTSTFVMSIQYRREIFYVPFMYLLRALTDLNDFQIFEHITRGRPDDGFFAACIKNMIRNARAEKVDSRRAALRALGSSFRVVLNDRLAPWETDEDAATFILRYCLCIHLSNDEDKFFCLIYQAQKLMALVQGQILGETPDSPQFQEASVSGHILLAFIRERLENQLVLLKRKLSFMEKKRGEKFALTEKAIQIAWGGQTAAEVTHGLEYFLATGNLLSKTGIGLMQTTGFAVIAERINQLRFVSHFRAVHRGSFFMEMRTTDARKLRPEAWGFICPVHTPDGAPCGLLNHITASCRIVNSYQSRPSKLLRTVTELGVIPHSLTELALIKNMYHVYIDGQFVGYIDRSRASAVVQHLRKIKITSSDTRIPSTAELTLIRHSTDPQNVLTQYPGLYIFTNPGRFMRPVKNLVFDTIEMIGTFEQVYLSVVIDPKEAEDGVTMHQELHPSALFSFAGNLIPFPDHNQSPRNVYQCQMGKQTMGIPVHAWHARCDNKMYRLQFPQKPLLKPEAYDMYQMDEYPLGTNACVAVISYTGYDMEDAMVINKSSYERGFAHGTVIKVEVVDLCEGIRFVNKENRKIFARDPNDITIQQFIGHDGLPYQGKLYRIGDPMYSYREEENKEYKIKKFKYVESAICGYVRIVESGPELGKTKALIQWRYPRNPIIGDKFASRHGQKGINSFLWPQESLPFSESGMVPDIIFNPHGFPSRMTIGMMIESMAGKAAAMHGEFYDASPFVFNEFINEIEKNTAINHFGELLQKAGYNYFGEEVLYSGITGQEMKVQIFFGIVYYQRLRHMIADKFQVRGTGPVDPATLQPVKGRKKGGGIRFGEMERDSLIAHGVAFCLQDRLLISSDLDSCKVCGNCGSLLTVTKNYRAEGEFKSYQESCTSCPDKIQKIYTMQVPRVFCYLAAELAAMNIRVITTVKAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSU7</accession>
    <name>A0A914YSU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSU7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20503.t1">
        <property type="protein sequence ID" value="PSU_v2.g20503.t1"/>
        <property type="gene ID" value="PSU_v2.g20503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20503.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15767" checksum="8867BC63F1B782E2" modified="2023-02-22" version="1">MDGNNSTTPQIMQFKASQKLLQPNQSLPQNPQEQKSRGIGTNEKSRVAINTMNQAPPSSRQLFSRASGQYAEMADTTIHRSDRPIREVENNNSLSGEGLSIRSNKKINPAVAKALEEIKAWFVRFTKKIYTNSQLFLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTR4</accession>
    <name>A0A914YTR4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20839.t1">
        <property type="protein sequence ID" value="PSU_v2.g20839.t1"/>
        <property type="gene ID" value="PSU_v2.g20839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20839.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14269" checksum="2E8BEFEB6560C39F" modified="2023-02-22" version="1">MVQESTMICIDNSEYMRNGDFTPTRLQCEQEAAHLVAQCKLRSNPENAVGVLSMADDVKVLSTMTQEDRKIFCRLHEINFEGTIKVIPAIKVAHLALKHRQNRNHKMRIVLFLGSPLESLEKAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUJ5</accession>
    <name>A0A914YUJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUJ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3340.t1">
        <property type="protein sequence ID" value="PSU_v2.g3340.t1"/>
        <property type="gene ID" value="PSU_v2.g3340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3340.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7838" checksum="FC09B5F82208DF5E" modified="2023-02-22" version="1">MFFCPNENMDTESMLEMNAKEHATLTMGQLASKRGKVNIVIDFTGKLVKAKRPPFTISAVETSQKNSFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWR7</accession>
    <name>A0A914YWR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Plant heme peroxidase family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWR7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4548.t1">
        <property type="protein sequence ID" value="PSU_v2.g4548.t1"/>
        <property type="gene ID" value="PSU_v2.g4548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4548.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="23886" checksum="8A0DC495092FE435" modified="2023-02-22" version="1">MAWHGAGTYRSIDGRGGAGRGQQRFAPLNSWPDNKISWADLFILAGNVALENSGFRTFGFGAGREDVWEPDLDVNWGDEKAWLTHRHPEALAKAPLGATEMGLIYVNPEGPDHSGEPLSAAAAIRATFGNMGMNDEETVALIAGGHTLGKTHGAGPTSNVGPDPEAAPIEEQGLGWASTYGSGVGADAITSGLEVVWTQTPTQWSNYFFENLFNGRRTGNYPGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXB7</accession>
    <name>A0A914YXB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2734.t1">
        <property type="protein sequence ID" value="PSU_v2.g2734.t1"/>
        <property type="gene ID" value="PSU_v2.g2734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="129"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2734.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32212" checksum="1DCD3B67FA1D9FEB" modified="2023-02-22" version="1">MKMLEELQNHHGKENLVAGADGDRYITFGFIIPSVPVEEEDDGEEKSVAEKSTQKKPEVICIEDEEEESVTEDGEENNADITRQEEDHFDNDDNWSETEEVSTTKSSEQKVLSKLGGKIAKLYENMEISDVCLSVNGEEIMAHKLILYLHSPCLAAMIKQDEWVSSSTKIDIEGFAPLTVQKALEFMYTETIVDVKKLLVDQMMELSRFATMFSISDLKEFINNQIINSVNTSTACELANLSSMYNEEEIHSTALEYITKNLANVKLDDSFAELSGENAKAILRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z075</accession>
    <name>A0A914Z075_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z075"/>
    <dbReference type="WBParaSite" id="PSU_v2.g614.t1">
        <property type="protein sequence ID" value="PSU_v2.g614.t1"/>
        <property type="gene ID" value="PSU_v2.g614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF8">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="342"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="463"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="875"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g614.t1"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118638" checksum="02B5E338F5148F61" modified="2023-02-22" version="1">MDSGQPKSGATAPIAGTSVPEPEKRWYYNSALGSCLQFDYLGTHGNANNFITKFHCESFCAFRCPRGQPQLESRRKGDDSNYASLVMTCSSNEDCKSIKYKCTKTLVNSQCCPNPEFICSEYGGIDGHFADAVLPITPQYSSGSNRFGREAQTRWYWNKQLRKCKTFRYLGQGGNYNNFATEQNCVDFCSRSLCPVGSPLRLESGENAECSNNQQCPRSHYCVSTVCCPTATTVCNEPLAMGAACQGEPVARYWFNAALRVCQMFQYNGCHGNGNNFISLDECQSFCDQVEEVPKCPRGEPLRIDTGRFWKCTSNRYEGNEKQCPTNYECHFDGNLSASYTCQLEFETGRPCNPGISFRWYFDSKAGVCKTFEYSGCDGNSNNFESQKSCEEYCGVSGCPLGGNILRKPNGEPMICDPKNVSSEAQKCPTSHECTLLSSSNPEISTISSDSYHYCCPTRYAICSESVEEGVACIDPSIRYAFDTTSKICRPFSYLGCGGNSNNFLTQQGCVHFCTSAACAAGEIVYRTKPDDPPYDCTKRACPFGFVCVADTANPKISVCCGSLNMGVCPNGQGAYIDERSQKPRTCSSDHPTECPSGYYCVFSSQRNKYYCCARHNYKQLKCPNTLTAAENPNTRRMMGCNHDSQCPPGSKCHKEKYEYHSGICCLEGPACPPTFTLDIERSRSGECSPLQPKSCSVDRHSVCLFSESMDRFVCCKREPRQPTDLTSCPGKMIRDPKKRLCSSNNICPPNYNCIRRNYDRIGICCRHRRTPATITVALRCPFHELPFRDEFGKVRLCSEMSTCPSGYRCELSQTLGTKSSICCKDPTLIEDTSCLHNLLPLSTEGNIQSCSNAACPSGYECSSNNFFYFLEFACSEPLYVGTKCVTEIPNERWYYHATTGRCQPFVFQGCTPSANNFPDEETCHKLCVNSKKRGSKSSNCPMPYQNPSQSRMQICSPVFDACREGERCVATPSGQYLCCVSPEKNTLKALISQLCGDFWKPILTPGSDDPQQCHPETNPCEKGQICRFSSIIRIHICCFPLFMVRAPSTFNYQKNVSIIPTYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0I2</accession>
    <name>A0A914Z0I2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z0I2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3783.t1">
        <property type="protein sequence ID" value="PSU_v2.g3783.t1"/>
        <property type="gene ID" value="PSU_v2.g3783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3783.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28871" checksum="AE0CD7904C35B581" modified="2023-02-22" version="1">MFIVHRADIKLDGQNATILEGYGGFNIPSVPYFSISHLLFLNNLNGVIASANIRGGSEYGEKWHENGMLHTKQNVFDDFVACAEYLIDNKFASPQKLAIHGGSNGGLLVGAVSQQRPDIIGAVINQVGLTDMLRFHKFTVGSAWIPEYGNPEKNKDDFECIYKYSPLHNIRIKPGVGWPATLLMSADHDDRAVCSHSLKYIAQLYHVVRKEAAEFQKKPLICRIEVNAGHGIGKPTTKIIDEFTDILSFVSQVLDAKYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1R1</accession>
    <name>A0A914Z1R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1R1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4199.t1">
        <property type="protein sequence ID" value="PSU_v2.g4199.t1"/>
        <property type="gene ID" value="PSU_v2.g4199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="113"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4199.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30611" checksum="CDAC3A5AED1E46AE" modified="2023-02-22" version="1">MEKDEIIAEEEDDVLNELVGAISIREHIRSISNSSTPDQQLPSPIHRRRRTSSNHSNSTIPFHRSTSQQPHENFAVVNARLIEDEELAVGKVSYKMYWDYIKAFGVFLAITYALFLFIFRTFFESFSNIWMAKWSSGFENNTDINDTKSLEIYGIFGILSCITSGIAAVLIAFGAFRASKILHDNLLYSLLRSPMNFFDTTPLGRILNRLSKDIEKIDNDVPQILTYTTILIGECMFYTVSALWMIPQVGFLSIPVMIIFVFITVSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2F2</accession>
    <name>A0A914Z2F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2F2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6250.t1">
        <property type="protein sequence ID" value="PSU_v2.g6250.t1"/>
        <property type="gene ID" value="PSU_v2.g6250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF2">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6250.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25977" checksum="B0C8BDC4063C84CE" modified="2023-02-22" version="1">MLPTITPISLVTPVTPEPLPDTTKSNITSELPTPPPFTDDAASIASSPIYLRPTRKPDKLHRRVDVTYRFNPCPSGKPLLNSFDTPVSCNYVVQPNGGCPEDYWCHTGSTFATTACCPTNNWGNRCLLARNSGDGDALVPRWYFDVSTKQCKRFLYKGLRGNSNNFITHTQCAEECEKEKAIIDTENPCRHGLPSRDPDAKRLICGPVDPSQCPKGHYCHIGENATTTACCQGSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z306</accession>
    <name>A0A914Z306_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z306"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6274.t1">
        <property type="protein sequence ID" value="PSU_v2.g6274.t1"/>
        <property type="gene ID" value="PSU_v2.g6274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000072">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6274.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27343" checksum="107488DC5847E2C2" modified="2023-02-22" version="1">MSRGSSAGFDRHITIFSPEGRVYQVEYAFKAVNSTNITAIGVKGTDSAVIAVQKRIPDRLVISDSVTSIYQLTPTIGCAMIGIIPDSKFQVRRAQIEAASWKYENGYNMSAEHLARRMADLNQYYTQNAEMRSLGTAMLLLSYEVEDGPQIFRVDPAGYYRGMRGVAVGVKQQSANGFLEKKFKKRTDYSTEETIELALESLQTALSGDLKSTEVEVVVVSKDFPTTRKLTTEEIDARLNAIAERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z353</accession>
    <name>A0A914Z353_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z353"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6786.t1">
        <property type="protein sequence ID" value="PSU_v2.g6786.t1"/>
        <property type="gene ID" value="PSU_v2.g6786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="12">
        <location>
            <begin position="50"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6786.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21929" checksum="FA36711188F3C4FE" modified="2023-02-22" version="1">MDDRFRTNNSRTPQQSTGRNSIFGRPSLYGQANARTSMRPSDAGRFSYGVQSSAMKKTIPHHMTKNTRNVRDKAYIEEQKEIIRNFLEIKSSQLDPKCLTSPTTNQFQALFEFIYSHLDPDYHFPAIMKSLKYPLQIKVSTMQSVSSGTSWPYLLDALGYLVTFVTKVETMNIMSLVDDEGSDSSRRFVTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z495</accession>
    <name>A0A914Z495_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z495"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6709.t1">
        <property type="protein sequence ID" value="PSU_v2.g6709.t1"/>
        <property type="gene ID" value="PSU_v2.g6709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6709.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25055" checksum="DC2CA1EB99CFC5FE" modified="2023-02-22" version="1">MCVKVHRDLFIFLQAHAKCNSEDSFIATAQNRYELKLLRNVIVPLNIENDMGNIGGFWAGIKTEGRTTYSMDGTKPMFHGKLKAIKLLSNFTADSHQSLEFVIDANLIPIIIEIAKENPEISFQKECANVLCNALMCAKKEQVQYLFNEGIGDSLCSFIENPNPEIIKIIIFDLSSILEIIDEVYQEIPLQIKASLQKSKGRNGFTDPQTVELLRHFLEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z616</accession>
    <name>A0A914Z616_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z616"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2093.t1">
        <property type="protein sequence ID" value="PSU_v2.g2093.t1"/>
        <property type="gene ID" value="PSU_v2.g2093"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g7781.t1">
        <property type="protein sequence ID" value="PSU_v2.g7781.t1"/>
        <property type="gene ID" value="PSU_v2.g7781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2093.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7781.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="13662" checksum="365F586AB0DD6FD5" modified="2023-02-22" version="1">MSGRGGKGAKAKTGGKAKSRSSRAGLQFPVGRLHRLLRKGHYAQRVGGGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRINPRHLQLAVRNDEELNKLLSGVTIAQGGVLPNINAMLLPKKTGGGAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z683</accession>
    <name>A0A914Z683_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z683"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8195.t1">
        <property type="protein sequence ID" value="PSU_v2.g8195.t1"/>
        <property type="gene ID" value="PSU_v2.g8195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060102">
        <property type="term" value="C:cuticular extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042329">
        <property type="term" value="F:structural constituent of collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF393">
        <property type="entry name" value="CUTICLE COLLAGEN ROL-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8195.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="37657" checksum="D039B3E78CF77664" modified="2023-02-22" version="1">MSVNKATVGAITFSGVTLLACLFAIGSIYSEVQSIWAELDAEMDGFKVLSDDLWRNMVRMGAGSPANRVRRQSYGGYGASGTNPGGYGGGPSQPGGSGPGGPSGPGGSGQPTLPGVGQHPNFPGNGGGPSGNNGAPNNQQCRCEAKSTCPPGPDGAAGEAGPDGLDGLPGQDGKDGQGADDIHQESPSGTFNCPAGPPGPSGPSGRPGIRGMRGPKGSPGFPGNDGFPGTPGEQGPPGAPGADGKPGQAGTKGNDADRPTARKGPRGNPGAQGDEGPQGDQGEAGAPGKPGEAGPAGAPGFQGPSGPDGEQGPEGPSGKIGNDAEYCPCPDRNGGGRGAHGGHGGSGGSGSGSHGGSGGSGAGDYGNGGGSSGGSSGGSSGGSSGGSNSGGSPYRKIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z849</accession>
    <name>A0A914Z849_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z849"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8503.t1">
        <property type="protein sequence ID" value="PSU_v2.g8503.t1"/>
        <property type="gene ID" value="PSU_v2.g8503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="134"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8503.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27677" checksum="AA505BBF96DEC176" modified="2023-02-22" version="1">MAFRYGLNHLTKVVIYHQEINFFAAPIYMPLWIPIFSLLFQSIFILILAFYFDAVIPIDDSPKKHPLFMFGMKYDDISESVKESELESLILEDSQKSSSAFSEFYFENDKNQMVAEIDVFHLSKKWSNNRFGVQDITFKAYQNQVTSILGHNGAGKSTTFSILAGFTKSSSGKVFVCGKEPRNLCQTSAVGYCPQWDPLFPHLDVREHLKFYQSLKGENNPEEIEEMIEKLGLCDFLEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z938</accession>
    <name>A0A914Z938_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z938"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9186.t1">
        <property type="protein sequence ID" value="PSU_v2.g9186.t1"/>
        <property type="gene ID" value="PSU_v2.g9186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="710"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="12">
        <location>
            <begin position="128"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9186.t1"/>
        </source>
    </evidence>
    <sequence length="829" mass="93752" checksum="F9881AE59C32652D" modified="2023-02-22" version="1">MENLNKTVDDEENFMTYDYSAHLQQCFGGPYTMQTVLNLSCFGEFGAPIEPYVILGDFNKTNDFNSARGLVITFLLENHLDKQLNKKASEWEKGFVEKLKKHKNEHYYFSFMTERSIEDEIDRASSSDKVTVIISYLFMFIYVAFALGQYRVSENQLGSLFVNSKFTLGIAGVIVVALSVTSSIGVFAFYGIPATMIILEVQPFLILAVGVDNIFLLVQAYQRHSVIDSQLSLKERIAVICGEVIPSMMLSSISESTCFFLGAITDMPAVKTFSLYAGLAILFNFAFQATCFLALFIIDVRRQEAGRPEFFCWLRYPKIDNTYEESYMYRFFKNYYAPALLRRGTRLLVTVVFAAWFASSCLVMRNINLGLDEKMAVPEDSYMLTHFRNMERFMSVGPPVYFVINGRLSYEYRRVQNRVCGGTGCDKESLGAQIARASRFSNNSYISHPAMNWVDDYVAWLQPSGSPPCCRFFKNNGSFCPATQSKDACSSCNVTFVDGRPVREMFYDHLGQFLSDNPTKECTKGGKAAFSNAVDYHTLKGITATYYMTYHTPLKTQADFIRAMDNARWLAKNISCTINSAYSFIDQFDAQPDPPVTVFAYSPYYVFYEQYENIVWAAIVQLMLSLVVIFIVTFVILGMDPWSAMIIVGTIACILVNLIGLMYWWNIDFNAISVVNLVMSVGISVEFCSHIVRAYSLSYKRTRTERTHEALATIGCSVLSGITFTKFGGVIVLAFAHTQIFQVFYFRMFFGIVIIGGLHGLVFLPVILSIIGPPLNKRKMREILISEGYYHANTIRTVASEHRVITSSSLESNKDLAVHQKLFSSSSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9B6</accession>
    <name>A0A914Z9B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myosin VIIa</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9B6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6841.t1">
        <property type="protein sequence ID" value="PSU_v2.g6841.t1"/>
        <property type="gene ID" value="PSU_v2.g6841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17092">
        <property type="entry name" value="FERM1_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17093">
        <property type="entry name" value="FERM2_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13198">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13199">
        <property type="entry name" value="FERM_C2_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000075">
        <property type="entry name" value="unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000036">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057096">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041793">
        <property type="entry name" value="MyoVII_FERM_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041794">
        <property type="entry name" value="MyoVII_FERM_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21998">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24522">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MyTH4" evidence="8">
        <location>
            <begin position="88"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="352"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="8">
        <location>
            <begin position="797"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="951"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6841.t1"/>
        </source>
    </evidence>
    <sequence length="1265" mass="144435" checksum="04CC54FE22182F3E" modified="2023-02-22" version="1">MIARTTAETPPNATLENGNHDIDIDSCFDFLQSDSASGTPVRGDLISPQPSPIYTITENEPFSMENLEGYQFAKFAATYFQGQASSQYSRKALRQPLLYHENSGDQIAALAVWITILRFMGDAPEPKIGASNSNAEGMDKIPIMTKLYSTLGKQFSRKEIEMASQAADFEASGMKVRKNGSISRIVSMTLKKKSSKTSDSSSVTTNGHHHHHQHGSESKNNGDTNSLHSDGLLENRPTTSLDKLHFIIGHGILRPDLRDEIYCQICKQLCNNPSKNSYARGWILLSLCVGCFAPSEKFIKYLYCFIREQGPRGTTKYSSYIEHRLRRTVQNGTRHQPPSYIELQATKSKKPLVLAVTFMDGTVKTLNADSATTARELCTLLSEKIGLTESFGFSLYIALFDKVSSLGAGNDHVLDAISQCEQYAKEQGRQERNAPWRLFFRKEIFTPWHSPKTDAVSTNLIYQQVIRGVKYGEYRCEKDEDLALLAAQQFYVDQNGPNLDVEKLEGSIPNYLPDFALTKQGQNTIEKWMQMIMHVFRKKFMGNKPVTVELVKDDLVTFAQYKWPLLFSRFYEAYKFAGPPLPKNEVIVAVNFTGIYVVDDKEEVLVEFSFPEITGITCTASKRLGTDTFTIQTITGDEYTFQSPNSDDIRELVVYFLSGLRSRSRFAVTIQEQKLDDKGTYLECHRGDLLILVEEFGNASAQFVKAENTRTGAHGNIPIELIYILPTITKPSSDILELFNRRTELSKLNAERGMTLLIPNTNAERPYTLERFATDNFRIQSKRSLSTNRKYVELWRHSREPLRHPLLKKLEGKAEPSAESLVSYLAIMKYMGDHPIKRPKHPVELTDIIFRAPLRYEVLRDETYCQLMKQLTDNPNIYTEERGWELMWLCIGLFPPSKSLYKEVNQFLRTRMNPIAADCLNRLQKTIKVGQRKYPPHQVEVEAIQHRTTQIFHKSFFPDGGEEAIEVESSTRARDFCNRIATRLGLHSADGFSLFVKIGEKVISMPENEFFFDFIHQLTDWVRQNRPSKETVTPIFAYQIYFMRKLWINVIPGEDINADLIFHYHQELPKYLRGYHHCTKKDVAHIAALILRAQTRDDKEPPFGQFSQIISDILPKEMLKNYSSSDWKKIILAEYQQLSVKTSAEAKIAFLKYISNWPTFGSAFFEVKQSSDPTMASKVLIAINKNGVNLFNQDTKEHIISYPFEVISNWTSGNTYFHMTVGNLMKGNRLLLETTLGYKMDDLLSSYIQSLISGQNQNTNREHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9I1</accession>
    <name>A0A914Z9I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4781 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9I1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8575.t1">
        <property type="protein sequence ID" value="PSU_v2.g8575.t1"/>
        <property type="gene ID" value="PSU_v2.g8575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031962">
        <property type="entry name" value="DUF4781"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21115">
        <property type="entry name" value="GH06117P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21115:SF0">
        <property type="entry name" value="GH06117P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16013">
        <property type="entry name" value="DUF4781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4781" evidence="1">
        <location>
            <begin position="155"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8575.t1"/>
        </source>
    </evidence>
    <sequence length="773" mass="87294" checksum="BA8FFD303CBBB750" modified="2023-02-22" version="1">MEVSGDIVQNEEPAKSDSDWWDEARQMQWNLRTSFCPADYDEYIISNISQLDERELLTTKLCYLIYGQPKEEDITNGSRYELQLEDEYEELIRDAEQESLAVLSLYKPYQKKKAKELTEKILSLERKYPDKLHAAIIFVCLRLLDSKFEDKSLPIPVIRILREPNNESNTDDTCWFVDLEGRAYKGWENYLSSNKLPKGEICFPINGIYSTRPIEKCQNESTSLLLNRGTTPSCSLVKRILSVTDTAVTVATFGALAIAVAGLAITVTPVVAAVGTGVGATSMIYGGTRSVSVLVDRGRHKQTLAPKDAESRGAWIGLAGTALAVGSIQATQALSSAAASAEEVGRGVQYTANIINTSAIGINTVGILNHGYSIFTDWQEERPISKFDLMQLSLSALLLTHSLINFKTAKSIIREAQTETLAEFEQKLDTKKSRKGYDRVKTALGDIETDPFVRNKRMIRTIRQIDDPRDFFRKAYELTKQNNRDHGGKNRITFGQNGGLLIGDKELSASSLSKLNKAEQAALLNDLSSITEGSLAEAVVADKVQKWNNAYIEKDQKLEKVIDEIPLLQSKGAKISVMLLKRHLPAIGKILQNVGDPENLQRIMTIAVDICESMGFRSPQSLFEIIIIIRRFISVSSNNNRNQSDVLKIMAEPNSFLVNEVRQNIVDMYFEQVNATEANFAWKYSDRARARHDFENYKDMMQLIKKESLSVRDYWQKLQEFFDKNEPKVTMDLEGIDEHLTYDNSEYKGEVVTHRLSDDVSNHEVLYFHRKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9V6</accession>
    <name>A0A914Z9V6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9V6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9100.t1">
        <property type="protein sequence ID" value="PSU_v2.g9100.t1"/>
        <property type="gene ID" value="PSU_v2.g9100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9100.t1"/>
        </source>
    </evidence>
    <sequence length="555" mass="59794" checksum="504859681F9260E3" modified="2023-02-22" version="1">MASKIGNKFHYNSNSSSTSTAGMFTSNPEYNKDAHEHNSVNAYVDPPPQASRNEKDEMPPPRTLSPRNCYNTIAEDYMSYDAVVDSRKASAAQAYPIRQVSIMSGSESTTNMASAVSAKLSDRPITEVSDYLMMNNGFKIPDEPLRFPMKEARSYVSDISDSNESCYSSAAKRAKRESTSDFGDDPNAHNQRTYSLGSKPPLTTMPIARDLSDITTLNPTSEEFKIDDIRKRAHSAGSKTWTRGTYRKVTESQDIRNRTNSFGTSSALAALRRQRQPKFIENDDHAVIDFSDGSNKGSMASIDSPLARSRNSSVGLHATNIRNAAETAAVASSNLIVEKLAAIKVEPSASPRGHGGYGHGYGYDDSMSSSTSSSTSKQSSSNRRGSAPDTSPLITDSDYVLMPGPGKTSRSTKLKKIPEKGSDTEEFDTMELNSSSYFDEDEEMMEELITPKRAYVTGTTLNQGGLEYAVIATSSAGPTARPAPSPSSLPIIQSFAPPLPISTQTSFSGGASTPPIGIITAPSFSTTAASSPKHSSASPNQNHCEYTVINPSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB61</accession>
    <name>A0A914ZB61_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZB61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9895.t1">
        <property type="protein sequence ID" value="PSU_v2.g9895.t1"/>
        <property type="gene ID" value="PSU_v2.g9895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="2"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9895.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34491" checksum="8311464ADFD94B0A" modified="2023-02-22" version="1">MLPAEVLKQAQQELRDWNGLGTSVMEVSHRGKEFIQVAEEAEKDFRDLLNVPSNYKVLFCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAASAIKEAKKYCTPNVFDAKVTVDGLRAVKPMREWQLSDNAAYMHYCPNETIDGIAIDETPDFGKDVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIGPAGLTIVIVREDLLGKANIACPSILDYSILNDNGSMFNTPPTFAWYLSGLVFKWLKANGGVAEMDKINQQKAELLYGVIDNSDFYRNDVAKANRSRMNVPFQLADSALDKLFLEESLLLAFMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBB8</accession>
    <name>A0A914ZBB8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Corrinoid adenosyltransferase MMAB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:co(I)rrinoid adenosyltransferase MMAB</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cob(I)alamin-[corrinoid adenosyltransferase] + ATP = apo-[corrinoid adenosyltransferase] + adenosylcob(III)alamin + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:56796"/>
            <dbReference type="Rhea" id="RHEA-COMP:14743"/>
            <dbReference type="Rhea" id="RHEA-COMP:14744"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60488"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:56797"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9052.t1">
        <property type="protein sequence ID" value="PSU_v2.g9052.t1"/>
        <property type="gene ID" value="PSU_v2.g9052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1200.10:FF:000001">
        <property type="entry name" value="Cob(I)yrinic acid a,c-diamide adenosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="11">
        <location>
            <begin position="28"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9052.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26033" checksum="7365BB58CF2CB14C" modified="2023-02-22" version="1">MYRSAVVLTRFLHTGPIVFRGFKPGRGTGDKGSSSLFNNERRWKDDEAFHALGNTDELSSFLGICREHSSEDCLEDVTELITRIQCILQDLGSHVATPPNSSKKKQERTVFDEKFVKYVDGLIDEFGDKTPTIRQFILPGGGPLGSHLQYARALCRRAERSLVPLVRDEAIDENALKFLNRLSDLLFVLGRYACLKTHNYELSYLPPLKNVEQEADVKATKLIDKKKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBK4</accession>
    <name>A0A914ZBK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBK4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9693.t1">
        <property type="protein sequence ID" value="PSU_v2.g9693.t1"/>
        <property type="gene ID" value="PSU_v2.g9693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF213">
        <property type="entry name" value="3'-5' RNA HELICASE YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="4">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="190"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="590"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9693.t1"/>
        </source>
    </evidence>
    <sequence length="918" mass="103473" checksum="6B36D97791791723" modified="2023-02-22" version="1">MIPQTGFSGGGGGGYGFGSRYRQRESQEIFSDPKMKEFVDSWKKEIDEFYRGPLKEFTLPIMSKDQRRYLHKLVRDKDLRSFSKGQEGSRYLTITKVSAYKYATVPVNEAHPLRLQKEQLDLIKEYLTAFPIDEEQVLKHYEDPARKHNNGHSMIYNDMLVPSPPNIHVAPFITAFRKTLPAYHMKSKIMETIRNYQIIMVTGGTGCGKTTQVPQFVLEEAAATQQKVRIICTQPRRLPAIAVAERVAKERGEELPGTVGYHIRLEQKTKYETVLTYCTSGVLSRLLTIDAIAKNVSHIILDEIHEREQNTDYLLIALREALHVRKDLKVILMSATMEGNRETFLRYFEKHSIGVVDIPSRLHNVDKFFLGDVLAMTSYLSGNPDVAPVTGAFPQVEQWAHDRSGATVGIPMQPCNTAPDLNQYGYLHSIHPSASTPSLQITDPIEQIATQITSSQSFVRQSSLYNDPIAAPYSAVIPTVAYENYAPPSAAPTTNGFYFEGGNGYASNGGYSHETTFNSGFRRDKDVDPMATLCQISAQIGPQPRKFDKQYANNLSRIPYSRETLCDLYNQSDARYFSNPDGIDHDLTTHVINFLMDSEEKGSILVFLPGYDDILAIRDRLRDQPCTQTRPEIYTLHSQMNSLDQQRVFEEIKDAGARKVILSTNIAEASLTIDDVIFVIDCGKVKEKMYDHYSRISQLKTVWIAKSNAEQRSGRAGRCRHGYCFRLYSEQEYGTMNDTQIAEMKRAAIHDVCLHAKMFAPESMSVKTFLGMAPEPPSSEAIDNSFAFLQQLGALFAFTNASPFDADVEPPSYSSLRKDIEPDITELGSIIAQLPLEPQLARMLLFGISLQCFNPIVTLVAALSHRDPFILPLGEERQLALSARDCLGGHDLSDHLMLIRAFYAYTDQNTRYRELPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBN8</accession>
    <name>A0A914ZBN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IRG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBN8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7664.t1">
        <property type="protein sequence ID" value="PSU_v2.g7664.t1"/>
        <property type="gene ID" value="PSU_v2.g7664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143:SF1">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="IRG-type G" evidence="4">
        <location>
            <begin position="117"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7664.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23208" checksum="B854FE5B0B16AE14" modified="2023-02-22" version="1">MLSIKEFDILHLILSLLILVTVGISFLLTIDRLYKRMRNIIGELCYDFDPNIYIDMINDFEERHAQIQTEKEIRIASEKIEKLDQEMKEEFKKRRKTIKEKIHEAKQLHNINENENNCYNFAFAGHTKTGKSSLINAIRGINDKEAIAAKVGITETTQIVQKYSYHDNNHKNIAINFYDIPGSGTLSHDASQYYQWLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC40</accession>
    <name>A0A914ZC40_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="19">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Golgi apparatus membrane</location>
            <topology evidence="2 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZC40"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9300.t1">
        <property type="protein sequence ID" value="PSU_v2.g9300.t1"/>
        <property type="gene ID" value="PSU_v2.g9300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23462">
        <property type="entry name" value="beta-trefoil_Ricin_Pgant9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000047">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="21">
        <location>
            <begin position="535"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9300.t1"/>
        </source>
    </evidence>
    <sequence length="669" mass="76740" checksum="7E410F02CA38CF55" modified="2023-02-22" version="1">MVFPRLVKKKSNLLKLLLLIPVLWLGSLIIFSNSPQEGSNLNYHDKPPPVENPKPAPHKKVEIIEGFGAPMPMNGGESNDEIKKDEPSDSQNEPAGIIPKPNRELFDPSLPIYKKGDTSQAGELGKTVKIDKTKLSPEERRKYDEGFQKNAFNQYASDMISVHRSLPLQTDEECKAEKYSSGLPNTSVIICFHNEAWSVLLRTVHSVLERTPDELLHEIILVDDFSDMEHTKKALDDYMAQYKKVKVLRLEKREGLIRARLRGAAIAKGTVLTYLDSHCECMEGWAEPLLDRIHRDQTTVVCPVIDVIDDNTFEYHYSKAFFTNVGGFDWSLQFNWHPIPERDRKARKRHIDPVRSPTMAGGLFSIHRDYFEKLGTYDPGFDIWGGENLEISFKIWMCGGTLEIVPCSHVGHIFRKRSPYKWRTGVNVLKRNSIRLAEVWLDEYKQYYYERINNQLGDFGDVSARKQLRDKLECKSFKWYLDNIFPELFVPGDAIAKGEVRNGGDIKPTRCLDCAVGRREKNKPVSLYPCHSQGGNQIRNGRSSHGHCVDSPVGEEHHNKAVVPYPCHLQGGNQYWMYSKDGEIRRDESCVDFAGKDVMIFPCHGMKGNQEWKYNHKIHQLLHVVTGKCLEMTKDGARLLMSPCDAENAYQNWTFKDYSEDKAREYNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDF7</accession>
    <name>A0A914ZDF7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZDF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8298.t1">
        <property type="protein sequence ID" value="PSU_v2.g8298.t1"/>
        <property type="gene ID" value="PSU_v2.g8298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038162464" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="37"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8298.t1"/>
        </source>
    </evidence>
    <sequence length="433" mass="49006" checksum="CADD58C280B7EDD4" modified="2023-02-22" version="1">MKWILQCLVLLCFGDVALSHFQVPGLPIVVLPEYTAHGIKNVTRKGTEAFLYLGLPYVKPPVRFEKPEPLTITPLSFLKLKEAKQWKPACHQVVDVYPSTNTSEDCLYLNIFTPTKVGLKDLPVFVFIHGGGYSYGYTQAYGYEYFVDNFISQNIIMVTLQYRLAHFGFFATRDHVINGNFAHFDQLEALKYIKRNIKAFGGDPNKITLSGHSAGSTSTHALSLSPKTKDLYNQEIHIAGSNYALWGIASEMVFNHSELIGTQVGCAQANTLERKKCLQKVDYKKFWEARVQLGLPDFVPDKIDIIYWSANFDNDFFGGKTLDELQAAAPKRRAMYGVDFGEGLLETIITDNPITNVFSKSRGAYVYENRTLANAEKIREVLLQMLTDPKFNSTTQNVIVDRIFAYYNIGIGANATDPLHYWYKLTEVRNIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQQ8</accession>
    <name>A0A914XQQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XQQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10343.t1">
        <property type="protein sequence ID" value="PSU_v2.g10343.t1"/>
        <property type="gene ID" value="PSU_v2.g10343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15856">
        <property type="entry name" value="SNARE_SNAP29C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000041">
        <property type="entry name" value="Synaptosomal-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="162"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10343.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25348" checksum="BECB1AD39AB71A00" modified="2023-02-22" version="1">MSNPFDSNEVRSYTTGRTAEDEINQYEREIEKILQESVDSTQRSVQRLEHSEQLGANTANELLSQREKLEKAEKNLDEIHRTTYETQRNLNSLKSFFGGFFKNKFSRAPKEPSADVPSSKSDNKLSSHLNEGSSSSARSTSIAGGPSLSADSRKTIQGTRFEAMDSQIDENLGQMSSQLGRLRDLGKALGDEVEDQNVMIGRIHDKAMRNDDTVRKQDDQMRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSL4</accession>
    <name>A0A914XSL4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">carbamoyl-phosphate synthase (ammonia)</fullName>
            <ecNumber evidence="4">6.3.4.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914XSL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10260.t1">
        <property type="protein sequence ID" value="PSU_v2.g10260.t1"/>
        <property type="gene ID" value="PSU_v2.g10260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="58"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10260.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23576" checksum="04EEE7B8DB8F675B" modified="2023-02-22" version="1">MVIKQERPTGILCTFGGQTALNCAVDLYRDKIFEKYNVQVLGTSIDTIITTEDRERFNEEIKSIGEQVAPSKAATSIEDAIAAAEIIGYPVLVRAAFALGGLGSGFANNASELQALAQKAFAYSNQVLIDKSLLGFKEIEYEVVRDAFDNCITVCNMENVDPVGIHTGESIVVAPSQTLNDLEYNALRETAVKVIRHFGIIGECNIQYALDPHKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSR1</accession>
    <name>A0A914XSR1_9BILA</name>
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        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10305.t1">
        <property type="protein sequence ID" value="PSU_v2.g10305.t1"/>
        <property type="gene ID" value="PSU_v2.g10305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10305.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16455" checksum="F6A429DC52715C73" modified="2023-02-22" version="1">MDHLTEVVENMYYDAGSTNIQAGLDMANEMFMSDGRIEVPNVALLITDGNYNAGGPPGPSADELKSLGVNLFTIGVGSEATTDLLIWASAPNCMFYYSLEGYTQLATVFPELLNAQICDVSVIASDNQTYVPGSKILVPHMDFWEMEKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT00</accession>
    <name>A0A914XT00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT00"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1009.t1">
        <property type="protein sequence ID" value="PSU_v2.g1009.t1"/>
        <property type="gene ID" value="PSU_v2.g1009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1009.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="25095" checksum="B36ED04B8E2F1C45" modified="2023-02-22" version="1">MSSSDGNTGFKRLDSDLLQTLRAMQNERYKIFQQQDVDKGRFDVTFEIEGKHLHAHKFTLTSISKPLDSWLSDRWTTKDEVVKIEDSSYDEFYEFLTFLYTSECKLTEENIVKMTDMAEFYGVQCLKELCDEFLAKNEKTVETIEELFNFAQKYSLPKLEDSLKSFFWNHYRTVCKSDAFIDFKKPFIEFLLAGDISLYKKQILFEGVNIQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTH2</accession>
    <name>A0A914XTH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11257.t1">
        <property type="protein sequence ID" value="PSU_v2.g11257.t1"/>
        <property type="gene ID" value="PSU_v2.g11257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056503">
        <property type="entry name" value="Spectrin_Dys-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23729">
        <property type="entry name" value="Spectrin_Dys-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="576"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="911"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="107"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="942"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1093"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11257.t1"/>
        </source>
    </evidence>
    <sequence length="1190" mass="135922" checksum="AE934A3C150487D1" modified="2023-02-22" version="1">MLLKHFLWLQEVERTTTNPLDICDLTQIYNNADKLQNNVDELKIRKAELERLRDELQNEEPSEKLIRKMDKVESEAARVGEICAIRQIELEKLISQMTQFLSEKTSIEAWLEEAKIALENAENVQKLDDNQLQIELDTIERFFNEMDEIKQKIINLNEQGATLLKQYRRDECHRMSHALSTINALWTKFNDNIRIRRAVLEARQTSRKDFSQALERFEEWLTEELKIVNDRVDQLHRLTSTLANAASLKQFVDQQHDLSAEIEAHMEVFELVNCVGGDALELINVPEEKQKMKSRLNRIRSDWEQLNAINKVLSERILAAQNEHDKLQDQLVFLTNWVNEKLELLQTEQLVVGDPALIQRQSGLIKDLEQAVESKEKEVDTCITEVRAYLMRHDLRPTFQTNFILSHKEDTEEQREADFVQGVQMQSDCDKLENDWKLFIEQLNLLSQVVREAHKEISDLSNALAEALLTVSSLEEKVDKCRAVEKLQLDQLKDAYGEALILTHSISEAQIRVEDVNDCAGKIQAENIALSSHLRAQIQAVNQRCRKLKKDLSNRKIAIERALKDFGPSSEHFMLGSVTAPWQRAISQTNLLPYYIDHINRTTQWDHPAMVSVMENLAEFNQVKFCAYRLAMKLRAIQKTACLDLIELSELKKALAKFSSKSYTETIQTDEMTMCLLPLFEDIHILHPDLLPRDSVILAVDLTMNLIFNIYDPSDFSCRDAVSRILSFEVTLVIFCKAPLEEKYKYLFQLVSANDSVDHKQLAILFYEIIQIPKFLGEAAAFGGSNVEPSVRSCFSSSHFPNTVTLDDFLKWLKMEPQSFIWLPVLHRITASENIKHEAKCNTTSKDDLRDFGNILLNKFRTVNQKTGYLPLETVYEGQPIETRQTAPINPESELIHRHIQLFATRLNKTRREKSKSVISQAHSEPRPPGPVNLKSPLQLVLNVEQMEKDELDSLLQKLKHENRSLRQSLNASRSRLTLNALGSSTLDNRRLSTASLSKRRRSSGTGFLLSDLEPHGSGHGHGHGNYSTLPAGFSLSRPPLPASMRTGSTPLYNNEQNLMLNLGKSQPVASSAPFIHGHDSGDIHDYRLEQRQKILIDQNRLLMRQLQRLKKQLAKQGKDPESPISVLPKNGISSVYTAEAYASENESDAQGRTTTDVEGLFHTVEGLGQAMEQFVVSVSNDDADALFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU27</accession>
    <name>A0A914XU27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU27"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10476.t1">
        <property type="protein sequence ID" value="PSU_v2.g10476.t1"/>
        <property type="gene ID" value="PSU_v2.g10476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433433" evidence="1">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10476.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8734" checksum="A0D30BD5E6F0DCD3" modified="2023-02-22" version="1">MKIGCILSIFILLFIFQFSAAVFCPFGSKSKECPGVCVMYSCKTNKTQSGCQDDFYRDCKEFENDVESIKKHNSTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU63</accession>
    <name>A0A914XU63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU63"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1079.t1">
        <property type="protein sequence ID" value="PSU_v2.g1079.t1"/>
        <property type="gene ID" value="PSU_v2.g1079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1079.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31497" checksum="0E39F7DC904F56A3" modified="2023-02-22" version="1">MASFIVGANITGVKIGDTVISCTITNTTVLCTEFEFTKNGYKFIDFTNSILDLKKSYDEIREQIIGTCDPTKIILASPGPNDPSVKAVKKILNLKNLIVIDEGIVGFTYKTVVELYKRMSDKSYLKRYVLPTSPRRYELGFIMGGKFYRCITAYDCDTLPFSKTGCIPRSSLEIALAYTNHATKAPEYLQRFNLPKNGHRFEFTLKVDKEGSPSYEMESHLIDFIEAIPEKLNRTGLKIPVISFFDNSTVISVYKEGKGYQFLESWGGNNFCCFFIALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUZ1</accession>
    <name>A0A914XUZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUZ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10788.t1">
        <property type="protein sequence ID" value="PSU_v2.g10788.t1"/>
        <property type="gene ID" value="PSU_v2.g10788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="55"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10788.t1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41353" checksum="5C57824A97BD8D82" modified="2023-02-22" version="1">MPSSQHMGPPSVMPSMGGVPSSNQTPQSSTGHSSTFTNSSPPISSDPLMDSTWDSPPNLLDFLLKAENKIKSLRESVIKETGQFEYAPKTEPLEPFSIFSIGRSATVNDIFHSLHSQLLLVIEWAKSLKPFADLSQGDQMALLKNFSSQHIVLCVAYRSINSFDSLKLLNDSLITRQNGDVHNFPDDFYRRDCERVMDQLVAPMRFMQMDDYEFIAMKACVLFNPVAKGLSGESVMKVLQTRRKIYASLEHYVNSKSVKDPSRVGDLTFFILSPLQSLAKSLSEDVLMTKMSGVARIDHLMEELVLEDSDNKEKPQGVDRQVSEVERKLSHPSANQQHPQDNIGSENAGNYGYDMLSTLSNYIIGPYACNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV68</accession>
    <name>A0A914XV68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XV68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11130.t1">
        <property type="protein sequence ID" value="PSU_v2.g11130.t1"/>
        <property type="gene ID" value="PSU_v2.g11130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11130.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24256" checksum="8BFEDC3CA1C24668" modified="2023-02-22" version="1">MKVDSNQLFHLQILNAAEKYSNQIALVDGKTRESLTFGLFRKRSFQFATVLSAHMFPSSGNLIRDTVLVVMPNTISYPFVFCGSALLGNPICGINSGATKEELQNAAMKCAAQYIVCTAELLDEILEAFDGTKMPIFVFGKHILNPHRSQPTQEIIDLNSEMEIAPFDEELVETLSARSRALVTIQDVLLTPLSSGTMGEPKCIQLTHKNFNSATIALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVI7</accession>
    <name>A0A914XVI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVI7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11247.t1">
        <property type="protein sequence ID" value="PSU_v2.g11247.t1"/>
        <property type="gene ID" value="PSU_v2.g11247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11247.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29230" checksum="B814D1FEEA785741" modified="2023-02-22" version="1">MLDEKIFKLRYQRADLEFELNGLQDEKMTLDDALSEDKKGEAFVRRKERQINAQTLILGRELFSLLLRDVAIEETSRKAFETRVARIEIETAKKAAERNDLQERVLMLQTECQADLEQKRYVYDEIHVLQKRTDSLDAQISMLIEWRKSLEYQIKSVRTAIKQRQNIVSDPVVKSSSLKDSENKYFQQTFEQKFLSRENEIGLSLNNSDNGSVNDGDNEESSLQELHSPKFLMKPGNEGTEEKCKFLKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVT4</accession>
    <name>A0A914XVT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVT4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1064.t1">
        <property type="protein sequence ID" value="PSU_v2.g1064.t1"/>
        <property type="gene ID" value="PSU_v2.g1064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1064.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8783" checksum="3F5F9A8E6BE057B4" modified="2023-02-22" version="1">MPYEKTVETEQTVNTLNRKDDGYENLEISKYGSKYVEEKSAIKTFKPKLSKEAQTQEGTSKKFPDQFNKKKQQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVY3</accession>
    <name>A0A914XVY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVY3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10687.t1">
        <property type="protein sequence ID" value="PSU_v2.g10687.t1"/>
        <property type="gene ID" value="PSU_v2.g10687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10687.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16878" checksum="E4CC6FB2F082D5F3" modified="2023-02-22" version="1">MSQLYLESTDKFAKKHYLSFIVGIVPYSKISKYLPGISRYNYDKAVDYALQAPKIKRETFKRERFDILKVNPFVDFISSDIVVTGLPFGTKTLKLSNTKLEIPSTLRLQKHFEIIEMYESYMEERGQSHLVLPRSTMFHLLDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX18</accession>
    <name>A0A914XX18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XX18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11512.t1">
        <property type="protein sequence ID" value="PSU_v2.g11512.t1"/>
        <property type="gene ID" value="PSU_v2.g11512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000001">
        <property type="entry name" value="protein phosphatase 1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012911">
        <property type="entry name" value="PP2C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07830">
        <property type="entry name" value="PP2C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 16" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11512.t1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45296" checksum="FDD94E3778081184" modified="2023-02-22" version="1">MGAFLDKPKTEKTNYLGNGRDYKYAVASMQGWRIDMEDAHHVEIKVQNSPPFDTWSFFAVFDGHAGSRVALHSAEHLLQTLLQTEEFKKLSEELKSSEGKITENAKQYIKDGMRTGFLQLDEEMSAFTSIKAGDEKERSGTTAICAILTPEHIFVANLGDSRGVVSRTTDDIFSTEDHKPYNEKERERILKAGGSVMIQRVNGSLAVSRALGDFDYKNVPGLCPTEQLVSPEPDIYILDRNTNEDEFFVLACDGIYDVLENDQLCELVRSRLQATDDLKQATNQVLDVCLSMGSRDNMTMILVVFDAAPKPDPEKGENERDWLRRADQKLDEILQTSENHGLDADYVMNMLRREGFEELPIPGGFHLARSLVDQKLQQLEANPQEHPENLQVRADSSDDNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYF3</accession>
    <name>A0A914XYF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYF3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11565.t1">
        <property type="protein sequence ID" value="PSU_v2.g11565.t1"/>
        <property type="gene ID" value="PSU_v2.g11565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11565.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28382" checksum="B54C3438521EF221" modified="2023-02-22" version="1">MAAFVDTVLPVLDEYGPQFLPKFNQLRVLFPVRFTNYVKNTQCLRRKIALQETNLKEIALKHLSFGVREAQADILAIFKNEPGNCMSNAVFSKMQALLDFECGGGKKFSFGDSSVNDISSEFDHGLDNAEVDEKREESDNAEEEEEEVFNLQNCLPTSNVHGIYSTTANFQLERSIYSKILRTATQNVNFMCDGNVKEHPKGGTLLVVNIKNAQNKVTPPLPLLKAEIECRTDGYRWGLNQDDPKQHVNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYH0</accession>
    <name>A0A914XYH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NLE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XYH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10739.t1">
        <property type="protein sequence ID" value="PSU_v2.g10739.t1"/>
        <property type="gene ID" value="PSU_v2.g10739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="235"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="357"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="441"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10739.t1"/>
        </source>
    </evidence>
    <sequence length="474" mass="52423" checksum="74FDBBB685C1DF47" modified="2023-02-22" version="1">MTSDQESRICVRLFAENGEELGNPVVLPTSTTSEELESLANQFLEKEDDPIPIAFRTSEGIDIIETIASSLKEELDVEKGVNLVYLPQAVFRVRPVTRCTSSLPGHSEPVISIQFSPDGQYLASGSGDKTVRLWDLHTELPKSTCKGHTHWVLCIAWSPNGKKLASACKNGEIFLWDPNTGNQIGKKLTGHKQWITSLAWAPLHSDPTCRLLASAGKDGDIRIWDTVRGVTERTLSGHTASVTCLRWGGEGLIYTGAQDRTVKVWRASDGVMCRSLTGHAHWINTLALNVDYVLRTGCFEPEKRCEYPGDDKVQEIALARYNAAKAVAGVELLVSGSDDFTMFLWEPVTKKQPIARLTGHQQLVNQVLFSPDTRIIASASFDKSIKLWDGRTGKFLTSLRGHVQSVYQISWSSDSRLLVSGSADSTLKIWDIRVKKFLLDLPGHGSDVFAVDWSPDGERVCSGGKDCVLKLWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYK8</accession>
    <name>A0A914XYK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1303.t1">
        <property type="protein sequence ID" value="PSU_v2.g1303.t1"/>
        <property type="gene ID" value="PSU_v2.g1303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1303.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12147" checksum="6221E106FD2B8AAA" modified="2023-02-22" version="1">MTPDELEYLAFSILDSGKRFRIFNTAVKMAEKIAESHGFWINDRDPTVPGDEEAWLQKEADNIVRTCVEIHGVPVPDFGANKSEYLDFIERHSLREIYQIGKILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ56</accession>
    <name>A0A914XZ56_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription factor IIF subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcription initiation factor IIF subunit beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZ56"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13228.t1">
        <property type="protein sequence ID" value="PSU_v2.g13228.t1"/>
        <property type="gene ID" value="PSU_v2.g13228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="11">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="10">
        <location>
            <begin position="221"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13228.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34123" checksum="3B2D94D1C21A478A" modified="2023-02-22" version="1">MTDTSSSSSRKRANTDFVDCERATRGVWLVKVPRYLSEIWEKNEGSDVGRLVQLSADVVKLISTTPEESSTAETKPSINGSTSSTARKDIRKIQDPSELKPIIAKNNKNVSAPKEHSFKFRNLDGQSLGVILEDKSHLKEDVDIKSGKLACEGRVVIRAECQPPNSEQYMKMKMDMFRQAKEPVSKAKQIDRAVVAFKPKAQHAENLKMDKTKKEVGARNIRAGREQVMDRIFDAFEKHQYYRLSDLQTLIQQPQGYLREILNDIAIYNTSPPHKSMWELKPEYRAYRATTGADDPMEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZC5</accession>
    <name>A0A914XZC5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11010.t1">
        <property type="protein sequence ID" value="PSU_v2.g11010.t1"/>
        <property type="gene ID" value="PSU_v2.g11010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11010.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9582" checksum="6103824C12DDF707" modified="2023-02-22" version="1">MKQVAQQEAEKARYLVEKAEQMKLAAITTAEGDAQASKLLAKAFSEAGDGLVELRKIEAAEDISKLLAKSKNVAYLPHDLNALMQLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0X3</accession>
    <name>A0A914Y0X3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0X3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11494.t1">
        <property type="protein sequence ID" value="PSU_v2.g11494.t1"/>
        <property type="gene ID" value="PSU_v2.g11494"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g11495.t1">
        <property type="protein sequence ID" value="PSU_v2.g11495.t1"/>
        <property type="gene ID" value="PSU_v2.g11495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11494.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11495.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12072" checksum="BBDD35A9860CCA67" modified="2023-02-22" version="1">MLKRFSSSYAKAVQKMLTGKPEWTETFMKYTSRCKVIDAKPNSHVKYEFTVTKDVLNAEEKLHEGCVATLLDVCMGNLICDENKIHLQQNGVTVDLEISFLNTQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1R2</accession>
    <name>A0A914Y1R2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y1R2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13398.t1">
        <property type="protein sequence ID" value="PSU_v2.g13398.t1"/>
        <property type="gene ID" value="PSU_v2.g13398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000044">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="195"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="311"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13398.t1"/>
        </source>
    </evidence>
    <sequence length="433" mass="47304" checksum="BFD63913A74A3F08" modified="2023-02-22" version="1">MGNCLGKKPPAPAPPSSLQGGGPGSSSSSGASAIGTLAMSHTTGTNSIILGNCNGGGDLTPTGSATAGAGVGAGGAGMILYPHEPKLIATSNNNNNINNNNIHKLSPSLTTDTSRKASTTRGGGGGGGATNLYIALFDYEARTDEDLSFKKNDILEILNDMQGDWWYARSLQSGKTGYIPSNYVAKEKSIDAQPWYFGKLRRVDAEKLLLMSMNEHGCFLVRDSESRHNEFSLSVRDGSTIKHYRIRQLDSGGYYIARRRPFSTLQDLIDHYSKDADGLCVQLNKPSARIETPQTSTFTYDDQWEIDRRTLRLIRQIGSGQFGEVWEARWNNTTPVAVKKLKPGTADVSDFLAEAQIMKKLRHNRLLQLYAVCTREEPILIITELMAENLLHFLQGRGRGSSMGQLVDLASQIADGMRYLEEKNFVSFLMGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y279</accession>
    <name>A0A914Y279_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y279"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13341.t1">
        <property type="protein sequence ID" value="PSU_v2.g13341.t1"/>
        <property type="gene ID" value="PSU_v2.g13341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13341.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38867" checksum="E1FB345A0996F318" modified="2023-02-22" version="1">MNYKRVNKDSTDRCWKKCRDLDDINPRPHKPDEKMKPIDNFTFLYDEQYLLSISWNPVPNADIYVVVHWATNSILQYSQIITTVPYLHNFTFSPHNLCQENAVQVVPISGIYGTGPMSDPNVIPPPRPQISPRLKLLSMIYEPKKYVSQNYEANGTITITFGYEPSAWPLGDEDLEVIPMFHMMLCAEPDLTQAIPVPEFSKGSQKYTIQGQIGSDMMYRKCKFIYSIQEVHSSQCDISEYVHAKTDDFGNVEISCDKVQNSECHKIESFRAPVCGQVDKFNYDVLERDKISWNNKASNISVNISYVPYSTNADRKPLYYVALYGDALPYDSSEEVCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2T6</accession>
    <name>A0A914Y2T6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y2T6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14492.t1">
        <property type="protein sequence ID" value="PSU_v2.g14492.t1"/>
        <property type="gene ID" value="PSU_v2.g14492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14492.t1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50420" checksum="638DAA857262078A" modified="2023-02-22" version="1">MTVFSKLINRTPFLSSCRIQHLYSTIFFSTDRSAADNEILAYYQKSIKEKQQQLHKHVQGSFKRRQTQAELSNLREAMITSEQKKQSQIIELAPSRISLEIMSSGTCNMEPCLLLRTLTRGYLINCPESTSRMLPYTSLRPNSINDILITSPNIRRIGGISGFMLSQEHGVAPTRIHGPKFVRAYLEFLRPFADAELGEVKYPGTVIEQSWDSGSYKDAAFTINYIPMQHFEPGADAFKPVKNLDERESVAYLIETNPCLRSIDMFKVLKHKVPKGPLIGKLKAGESILLPDGRMITPEDVYMDDEDPSQLKDSKVLIIDAVTMPQLNRFMASPTMQPYFNGSKKLDYIVHLTKPEIFDSELYQSFSSKFDISKTTQIIANGTGAPDPHLESVYRLQAGHSLIDKNFFPSLWPNFEGIINGESSKVIDKKGRIFARPLQRYKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2W7</accession>
    <name>A0A914Y2W7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2W7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13581.t1">
        <property type="protein sequence ID" value="PSU_v2.g13581.t1"/>
        <property type="gene ID" value="PSU_v2.g13581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13581.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15212" checksum="E83468897A67220E" modified="2023-02-22" version="1">METNATMGYIIRLILNVINYLKHTPAYKLSLELQTLPIHREDNDLDLEGSFYDEIIKNDPKEQQRNKKKLKKKKVRKNAAASAAAEDETAEAEMIEEFEDNIPKLEEILQHIDFSDAIVVTEDSCPGLPSISPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y397</accession>
    <name>A0A914Y397_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y397"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1466.t1">
        <property type="protein sequence ID" value="PSU_v2.g1466.t1"/>
        <property type="gene ID" value="PSU_v2.g1466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46178">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46178:SF9">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1466.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20010" checksum="9F2ABB5B521A255A" modified="2023-02-22" version="1">MIITSSGPLAKISGISKILLVINDSLFLLVVLIIPSNFVYRYIQLCKNNLFEFKHGIAIVFLVIIGWGIYVSSIIAVMTRGKEYENEFEQFITSNLPLNLHKITFFGGYMHNVDLQLCVISAVIQIILSYLIISYCIFGIITYLRKNQSQFSLGKLRIQNQVTKALLGQVRLFKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3D3</accession>
    <name>A0A914Y3D3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3D3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12274.t1">
        <property type="protein sequence ID" value="PSU_v2.g12274.t1"/>
        <property type="gene ID" value="PSU_v2.g12274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12274.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19125" checksum="8C4381E0958A40AE" modified="2023-02-22" version="1">MKIFNLVESIKADLADVIPNVPFYKMDKSFLTHFVVAKGIISADQASHVFDTLVEITNNGDVVSGAFKDDDIGILRSFKKKKSRQSTRQSTKKIRFLSLKFPIPSTPSTVTKMAGVEWYLCLAKDQVLTFKHHSMVERSDYLLTEMRSDTEFQLTPNATTFITGRINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3W1</accession>
    <name>A0A914Y3W1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3W1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13469.t1">
        <property type="protein sequence ID" value="PSU_v2.g13469.t1"/>
        <property type="gene ID" value="PSU_v2.g13469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="719"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13469.t1"/>
        </source>
    </evidence>
    <sequence length="1116" mass="130345" checksum="04FA20FCA77612F3" modified="2023-02-22" version="1">MVLEKNTDDFHFEFHSEFIDNKNLVPQVLRLRSMLVEKFKNSLKKENKKNILMEKEISKGFGAQFNDRKMTPAEKEENAKALASALAKTLNNEEHTSVDNGFIKLSEIIDNLNRFKKYKEIFCKTLLKEYNYETEIRELLKRNFEKTPYFGEHFTKPEAPTEITCLCTLLIKIIKSDADKPKKNLNDVDAQKMKSLAGHVLVYHKNENCLIFSEAFFNDKIPESYKTFKKMLMEEMEKNALNYDYLRLIKFKLKTPTFQSCFEDRNVETELPLDSDNIEEKVSKFLKHFILVISPHETELSNLIKKEVSVAPNINLLDADFATNHTLVEVLDWMKAESSILFSKDKAEIIFKSLNSKISALMLAGNNSEYCKKLREYFPISANFMVNSEINSVFQNSMKSKIKNFLNSTSYILFLTSEGPICTLAIKVEQSLREIGSELINGYSLTSKDSFVFNPLSRILRMEEDVINILNRPKQKTLLIIVCYEDSKTCDSIIDKVNEDNKIIFIGSKNSKIFQTLEVRPQNFETDNDSNNDFSSLTEKAQKYLLNKNVKFYDEIVSLEQVFDLQAAKGLVDAILFEKLVLNDEVKLIEKKENCFDRHDIDYYVSRGFYQCTEFTESVIDYIKNVPTDAIVIEQYESNDTIFKNISIVNYNEAEVKYNELCKKYNNVHWLKKEFNKFFWIKSHGSIAKLVMHQVHSESESNEHDNARIYSKNEILQFVEGNKILILSNVAGMGKSIITSKMACFFQNMNAAFIVVKISFTDHRPILQRIKFDDNEQLVLNLENMDDEILKKGKELIHLLFCLKNETLKKQGFEEKLFQYYFKNGRMIIMFDGFDEIMENMKVIVLKFISKLKSSTKHKIWITSRVAFKETLETTFDAFSFTLKPFDDKDQTKFLKKYWTSKYSKINDNKTALTAEIEEKIRIYAAKFLDLYKDSIQEKNRNFIGIPLQLEMLAEIYKRKEKKDDKWEGCFDYIENAIDDSPTLPPIINLFQLYEKFVEIKIKDKYYYGKTRTQRGDPILDPMFKSRFEDALNYHQLFALALLVSDESLKQILLHSKQDELKGWTDKMKSGEENAGIIIKIVDGKPHFIHLTFAEYFAALYLTKNCVKASEFPDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5Y9</accession>
    <name>A0A914Y5Y9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5Y9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14861.t1">
        <property type="protein sequence ID" value="PSU_v2.g14861.t1"/>
        <property type="gene ID" value="PSU_v2.g14861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14861.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19972" checksum="5D998A8EB7FF0E46" modified="2023-02-22" version="1">MKPKNRGSTKTDSLSGRHEVGMLGLVESPSESLKRHCNATGSDDLIDAKLESYYKPGVVRVLQRIEIAVFCCKISSMMKQLDVLIDMAEEALAERDVKFDEDGNILHITQKAEQYLERKSTPEFIRSYAFGQIYRTVLDSHVGIFNTLSIPLLFVIVLQKRYTVLNRRKACAWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y794</accession>
    <name>A0A914Y794_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y794"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16083.t1">
        <property type="protein sequence ID" value="PSU_v2.g16083.t1"/>
        <property type="gene ID" value="PSU_v2.g16083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="303"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16083.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58503" checksum="3FED0B7CA053C983" modified="2023-02-22" version="1">MQSCGEAAFIVTDPFREECENGVRKRKLQVVDSFPLPPNSSHASVGKPKNGNNSAFTVTGTVVRKAPKTMPSKATIIENSLSVFQEYMKEPAPIDVKCSIKADDMQEPRPKDDNCPEVESSCSNLTLNQSEVVPSSQPEEDAENVKKLYHSLFKKPEIVPSSQPENDPNEDDEVAELEQLVSGTPVSSGRIEIVDDSEKKSLFAPRILRSHTSHNKSLVPYDVSPFRTPVRTRQFNRSFEKQSESDFIDDSAISGKSKRSSSNRFTPSKGKVPELPADYDQLLEAMNFQTKGRKQCDEAFGKLEIKGYDLYSLRTRQYVNDLIIDNYLKLVCKRSCDDDRTYRKSYAFGTYFYTIMNNGQNLDKLVSWVKEDLFQYELLFLPINQENHWFLFVADTVNRNFFIYDSLHYGEYVSEVNQIVNFLKYYAAKKNHEIDWDDWSNLPIVEQQGPAQSNGVDCGIFLCQYAEHLSRRATLDFAQCGMVNYRKIMLYELMNGELLPKFDDNKSALKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7C1</accession>
    <name>A0A914Y7C1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7C1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14642.t1">
        <property type="protein sequence ID" value="PSU_v2.g14642.t1"/>
        <property type="gene ID" value="PSU_v2.g14642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="131"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14642.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30357" checksum="EC1C6F4D9D6C9C02" modified="2023-02-22" version="1">MTPELLRLARLKAMFPLMAKLQIISHSKLQKSDNNALVQNFDNIQQNVVSENDNLINDKSEMITVTTDETINDKNELNASETMESSETTKIKPLNDLIDLLKTKSQNQISTALIKLANYTIENKDEIIQAGIVPYFVKHLNSEDIELCKISAQALYNISIDTDEQKQSIINSNGIIPLIDSLNSSDAEIAVTSCETIINMLAGTDQQFQAVINANVIPTLINLLNSSNDNAKIALNISERNSLQKAIILDLAPLLIEFLNCPNIEVCKFAAQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7L1</accession>
    <name>A0A914Y7L1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7L1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15441.t1">
        <property type="protein sequence ID" value="PSU_v2.g15441.t1"/>
        <property type="gene ID" value="PSU_v2.g15441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15441.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13516" checksum="BF06A8814F674D99" modified="2023-02-22" version="1">MAKYDQASSPEINESPQNRELCVFYKRIGACRHGLKCSRLHIPPEKSKSIMIRNLYRHVQPLTAQIASSSPDSLGIFEDFYEEVFKEIDEAYGRINQMHVCENMGEHLIGNVYIKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9U6</accession>
    <name>A0A914Y9U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9U6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16053.t1">
        <property type="protein sequence ID" value="PSU_v2.g16053.t1"/>
        <property type="gene ID" value="PSU_v2.g16053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="100"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16053.t1"/>
        </source>
    </evidence>
    <sequence length="543" mass="61331" checksum="14AB24D1AF7EFA69" modified="2023-02-22" version="1">MKNPVEHLSNLYDPLKMLVSPPTAEDSEPSDEEFPSLQKQRHISKSTNSLTLEQMKQQVKTKSAITSPTVSRLKINSTVTPIVADATILGSFPNKLLNKDKFEKAFVLYSFSAAHGDEMDLIENTIITILDKHCAEEGWYLGEYEGKKGIFPSSFVQIIDLSQVTPPKNDVSDKVYSNIKSSPINITKMKPVNTTHNNNQIQSNSTDFVAATKTFTSKHYETSPTSLQAKIKPYLTGPSMKLSIKNAEKSVDASLKIKDLQMQLMYLNHTVESDAISSKENDFFEAKTTEERKLNPSNTTISEIFSSYNLNTTSKNFKNAEIQTDETSFSQDKQIQKMYSPKDYRNDSEFRKSISPNLSTPLSFSPNKYGNYRKSTLAGSSEFPKISDSDFSPFSTTSPMHEYDVENLSAATVTFSFKKDETFGVEIYQNGRNCILKNVFGFEWTPLYFSMAEDAPKVGEKAQIHHLQYPKHVIYDILKIIGKSMNEIEINPKWEFKVVENNGTKCFQIETKNGPRLFPENFIVAAFLKAMNVSLKTVVLVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAY0</accession>
    <name>A0A914YAY0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibulin C-terminal Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAY0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14648.t1">
        <property type="protein sequence ID" value="PSU_v2.g14648.t1"/>
        <property type="gene ID" value="PSU_v2.g14648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055088">
        <property type="entry name" value="Fibulin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22914">
        <property type="entry name" value="Fibulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibulin C-terminal Ig-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14648.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13012" checksum="21C3F53B5CA23600" modified="2023-02-22" version="1">MDHFCLGNFTKEILYQFAAIPSLKQIYKPIEVSKIRVQMNTPFSVEYYLDPKNQEHFIVEQKDNLGIVKIQKPIKGPANEIVRLHINTKSRTNSLLAHNVAIIRVDVSRYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBH9</accession>
    <name>A0A914YBH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBH9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16119.t1">
        <property type="protein sequence ID" value="PSU_v2.g16119.t1"/>
        <property type="gene ID" value="PSU_v2.g16119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16119.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20962" checksum="F58A558A8DCA0EAB" modified="2023-02-22" version="1">MKSIKCVVVGDGAVGKTSLLLSYTTNSFPGEYIPTVFDNYSTTITVNEQEYGFALWDTAGQEDYDRLRPLSYPLTDCFVLCFSLVNYMSFENIKKRWLPELVHHCPNASIILVGTKKDLRDDPERLSISSEEGHQMAKEINAIKYFECSALTQFGLKDVFDEAICASLFPSKEKIKNRKKSCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBI2</accession>
    <name>A0A914YBI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16635.t1">
        <property type="protein sequence ID" value="PSU_v2.g16635.t1"/>
        <property type="gene ID" value="PSU_v2.g16635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16635.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14594" checksum="E83B5C83419DF4F5" modified="2023-02-22" version="1">MIFVITDYPNQTSSYLVATDDFALKVKGTFLDALQSLMELHYIFDLAYAKELKPFFILMERLASININKTFSTINDLYGDLQRKADSICASAPENPVADAPAPQNPAPDEPSDPVAAPNALSPIPEEDEEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBJ5</accession>
    <name>A0A914YBJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">V-type proton ATPase subunit G</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBJ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16140.t1">
        <property type="protein sequence ID" value="PSU_v2.g16140.t1"/>
        <property type="gene ID" value="PSU_v2.g16140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16140.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13684" checksum="DEB09CB1A5C8B306" modified="2023-02-22" version="1">MSRAYRIKILKQAKIDAEIESNAFRKQKDDIIKEKFCQVDHDIELEKIVYDRQVDATIKKYDEHVAQVKERVIGNLLDLVMDIKPEIHHNFKVRKEINETGTYTRIIDPLQSASRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCG8</accession>
    <name>A0A914YCG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRIB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCG8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16995.t1">
        <property type="protein sequence ID" value="PSU_v2.g16995.t1"/>
        <property type="gene ID" value="PSU_v2.g16995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16995.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31030" checksum="80D40DE391BFDC66" modified="2023-02-22" version="1">MPTHWDVLLQNSKISKQEQQQNPQAVLDALQYYTRPSMTQQKWLNYDSGYGNCIDQLSASPFFQKQGLSSSNGTYSSNSLPHLHHINHHQSSQQQQQQQQQLHHSQQQQQQYQKPQLIQKDSFTRTSGTSSNGSTTTTSKASSNLSDEGIQLPDLISPAKSTSHISSQNNGMHGIKTNGSLSIKDGPLFSRTPASEPSVPSYAPPSVPKEEAPPIIPERPTKTMSIYTKPKEEEVIKDLSNGGFGRNAARAKRRVTDIEVLAKLKTIVTIGNPDRKYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YET3</accession>
    <name>A0A914YET3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YET3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1781.t1">
        <property type="protein sequence ID" value="PSU_v2.g1781.t1"/>
        <property type="gene ID" value="PSU_v2.g1781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="1">
        <location>
            <begin position="66"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="2">
        <location>
            <begin position="206"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1781.t1"/>
        </source>
    </evidence>
    <sequence length="1001" mass="113185" checksum="FC828948EA7A4F7B" modified="2023-02-22" version="1">MAFRSARVPKMTQTIFKQVCSVQSNNRLKVSLYRSTLSGMRVAFVDQPSPVVNGWFSFATKATSDDGLPHTLEHLVFMGSHKYPYKGFLDSIANRCFASGTNGYTDEDHTAYSITTVGSEGFLKTLPVYLDHLLYPMLTPEQFTTEIHHINGEGRDGGVVYAEMQDHENDMDTRIDFTRRRLAFPEGNPFRCNTGGALPALRDLCSLERVTDFHKQHYNHTNMIITIVGPVDENKVIDILSNLETFGYQRSTSKKRPFDDVVLPERYDPKIEHVQCPVEDETNGTVSVTWQGPLHADPDISALQILLSYFCDGPDSPLQQRFVQIKDPICSDVSRESRERSRVELALRFGGVKRKFLKDEDLFSNIPLNVLRESKIDMDRMKAMIEQQIHQMDVMLEGNPTQYYHGIFSVYALYAPGVNASSDNVPYLEKRLNEVTNLKSLLQRDATYWEGLVKKYFTKDQIIVIGNPNAKLVDELAQKEEERVKAQIEKLGPEGVKKCGEALQKAVAKNEASAPTEDILRNFIVNQIDVKLIDVEREHKSSNSSNPYPTICHKVDSNFLHATVLFDLHSLPAEHRSAIQLYMELLTESDVKINGKVVSYENVATMLKKDFIAHKIDLGLKKDYEEFLAFHYILLPEKFENIAKWTEIFLKNVIFENSRIASVAKRLAGNASELKQDGDAIAQALMTKMIAAKDSNRLFNCLLSSAKFHKDVADHASSGTSDKMVNIMNDLAEKITACPANIHLIGNSDSLKTATSKGWKVTSKVENTTEFLTGSSEYSLDLSQNKGSTFCIPHGSSESAFLIQRSEAKFDFLDPRIVYAKLLSQYFCQCEGPLFTHIRGKGLAYGVYIYVTGNTGLGFYLYRAADMIKAYDESKRVVLETITSRTVDADQFEAAKRSLISDLVQSVSHVRKAGKFSIVEQLRGIAPNQSIVKYQVDQIWQATPEQMFDAVSQNFVDLFDDEKCIRSVVPYKTDLKKTQQFFKNTKTMKIDNLYFKNLITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEX7</accession>
    <name>A0A914YEX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g1786.t1">
        <property type="protein sequence ID" value="PSU_v2.g1786.t1"/>
        <property type="gene ID" value="PSU_v2.g1786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="1235"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="1320"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="797"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="879"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1156"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1472"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1558"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="803"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1162"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1509"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1560"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1786.t1"/>
        </source>
    </evidence>
    <sequence length="1591" mass="180728" checksum="A11DAEEB63852169" modified="2023-02-22" version="1">MDENEQDRVQSDDDGEPPAWRYGPSQIWYDRMNVPPNPKHFDYGIKTLQKRFQAPSKLQNRNLFGAPSQDEESGYEPAEKLSEKSFLPVNLVRWEDDIIFDVEDAKETFLKDYSSGKLPYCGWIALKNARTYNSFMKLYRRYAPKDWFKAEPMKDAQEEKSSYPVDPHHSMFPVDNYDLEHTNWEEDIIWDLTELKKPLEPKILTLDFEDDPKIFGLPDDIPLDEVDSEDVKSFERKDHQFTKKSKLILGQVQQRQKQEEQEQLENTMAQIADRDPFNLSNDDYYALKTTTRQNVVFSGGSVIQHSIPAQNIHRAFFPTCMGPTRLRHFHRMPMQRKILRSLPMDKYGFIDVMSLNKHMLDMAEVREKRKLSEAGLEVFPVRDIKDLSAKDGTLLLFEFSEEHPPLLNQPGMANKIRNYYKRQNNKDPDLELDFGETAFTHTFPFLGNLEPGESLQAIENNMFRAPIYQHTPKTTDYLLIKSGNSLILRKCPIPFVVGQECPLQEVPNPNSKKASIFVRDFLLAFIYRLFWASKDTPRRLKMDDIKAAFPHYAESSVRKRLKGCSDFKRLGPGTESNYWILKEDFRLPSKEEVLAMISPEMCCANYSMLAAEQRLKDAGYGEKYIFAGDIDEKNESDDEVTIEDEIKCAPWNTTRAFLAAQRGKCVLDQSGIADPTGCGAGYSYVRVSAKPQKEDIPQVPKRLVTGTNADLRKLPLKEAKEICKQYGVRDEEINALSRWEIIDVIRTLSTQAAKARSDLSGMARFARGNIRLNYADMQQKYKQYCQRIFDLQNKTLGNPVELSTDDDSSAEEDEDNEEMVARLENILTTALGKKTSPSSTVPRKLKKPINGGGGGSGKKVGEGDQKDFDELMKMIHGDKEDSQMSSGSPVSSVPPPPGPSTAATTTTSADKEPLPKALLNFAPGSDEMVVAQNLKISRKALEMLVSRDNKTKKLKIIRTFLDGDGREVVRSEIISNSQVVEAYVKVRTTKDEKFIREYSHKDEEYKEEKRKEKRRLQDQLRRIKRNEERQKQGIPPKKPTVPPKPKPQKESLLKMKCSACGGTGHMKTNKNCPLYGKTPPATSAFPTVRDMLGAHQLEDGNSRGEVTEVEGTKLRIKKAALNDKSFLKMKIPKLMLKQSKGSSQHPNERDLKAALSTADSGNHTDDGSSDERKADKIPRPKGRPPKIATLNRRKSTIEDSAVDYLSGPHKSVHRRRADPKVLMSTTLGEIYADLKSVPGSEALMFPVNAKKVPDYYKVITEPMDMQQIKQQKICLILLHKKIQLNESKLVELEKQINPLLHEDDLVGFSYILEEIVEACKNVPKSAAFHTKVDARKLPNYYDKIKNPMHFGMILQNIKDHKYFTVGQFRRDVEQIKINSEIYNGQMNPYTLKAKEVVDYVDRLIYQRRDQLSELETNIRGKKAAEGVPIIEEENFSLETIIQQKQSDFNESTGTLPPASPQYQISEYDAMSVGGDSDRPMTESIILGDDDETRAGFDDDSAGVLNDDLALSDEDDDDDDDDEMAPSQIVPYSDFDTEDDEATRDNFANLAASNMSAAGQLSTDLALSSSSESDDDIISAKRPRLDEDFETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF82</accession>
    <name>A0A914YF82_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease P protein subunit p29</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YF82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17977.t1">
        <property type="protein sequence ID" value="PSU_v2.g17977.t1"/>
        <property type="gene ID" value="PSU_v2.g17977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17977.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20969" checksum="CD16B3A8B80CF01A" modified="2023-02-22" version="1">MSEPTTSTNRKDGGRYFLFDATKKKIKPGPKKTAPQSIIKRAGGLSSASLKYSDYIPLYELWCGYFSELLSSMKQPDERLLKTDYHGCILYVTDSPNSSQLGLYGIVLHESKSTFQLLTKKDKLVVIQKEHTTFQFVFQNRVFTLFGDALGQRSFARGKKFKGRLTLPFFLPTNESPSSKSVTSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFB0</accession>
    <name>A0A914YFB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LRRFIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16057.t1">
        <property type="protein sequence ID" value="PSU_v2.g16057.t1"/>
        <property type="gene ID" value="PSU_v2.g16057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019139">
        <property type="entry name" value="LRRFIP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212:SF0">
        <property type="entry name" value="LD07988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212">
        <property type="entry name" value="LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09738">
        <property type="entry name" value="LRRFIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="263"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16057.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40013" checksum="F49341530C967F04" modified="2023-02-22" version="1">MTSHSPQGGRRIRAPVGHDAEEIIMGKISRQGGEVFSKKRQTRDEARQLRMEQLEKQIRADDDSNYLIADSNAEKVNELEDKFQRAMLLYSQLDNEKSTLLYEIDLLKDEMEEKDQILYQNTRENRDLTSHVKSLQRTIEGMQATHQSLKNEIAQRDQIIQENGLMLAEQETDESSAISSCEGSGSTINIRPGPLLFTQQTISLVEKAIPGSSAIDEKVRKLCDMNKKLRQQVEETEQTLYARRRFNDHHASTVNGAANEAAERDAAKQVSELKLKLQEAERENTNNQGNLIRLDGQLKRLKQTSEQSDKECVELKSQNRNLKKELRDKEMALDEANEQINIYKVAWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHD0</accession>
    <name>A0A914YHD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHD0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18874.t1">
        <property type="protein sequence ID" value="PSU_v2.g18874.t1"/>
        <property type="gene ID" value="PSU_v2.g18874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18874.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14444" checksum="BC002149483072A6" modified="2023-02-22" version="1">MMACIFGTVGIAINVMPVLVIPLMAFAGFYININTLPVYFLPLRYISYFAYGFEALAVNEWSRIDEIGGCSKLPKNSSLCLSTGHEVLESLGFKESNLWPNIIILFSMILIFRIIAFIALWIRVETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHX8</accession>
    <name>A0A914YHX8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHX8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18927.t1">
        <property type="protein sequence ID" value="PSU_v2.g18927.t1"/>
        <property type="gene ID" value="PSU_v2.g18927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18927.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20998" checksum="0762A3C96D42E02C" modified="2023-02-22" version="1">MEEDKDAKAMAKYAINKAKKEIKKAKKVIKAAKKMSKNSTKQAKKKRSKKGKESCSSSSSSSDSDSTDISSSSCSDSEEERKSNKKKKAKQWVDKESQSDREEETTQSEEKEVPYRIPEIKRCNDSRRSRRVREDERRHKKDIERSKRHDDERKSRRKSRDQKPNLKFDLQIKIPKNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHY6</accession>
    <name>A0A914YHY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19094.t1">
        <property type="protein sequence ID" value="PSU_v2.g19094.t1"/>
        <property type="gene ID" value="PSU_v2.g19094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19094.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14915" checksum="169751ACAEF1F232" modified="2023-02-22" version="1">MLQNPLLGRYKIVLICKNEDWDFNELDPNDDLKIFIVTEVEGVNVPNVGLVIDCGMHKKHSEYSAAGKYKLQQFFGNEGTVLQRMGRTGRTCDGFYVIMLAVSHYEWMKIQPAERALDSNIVEVILIFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI84</accession>
    <name>A0A914YI84_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galactose mutarotase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YI84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19024.t1">
        <property type="protein sequence ID" value="PSU_v2.g19024.t1"/>
        <property type="gene ID" value="PSU_v2.g19024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008277">
        <property type="entry name" value="PRK11055.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="53"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19024.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35583" checksum="60359AEBF56A0A0E" modified="2023-02-22" version="1">MSIKIIEYGAILVSIEIPDGYGKKENVTLGYDTLEEYLHNPNYFGATVGRYANRIAKGKFVIDGITYNLPINNGPNSLHGGKNGFDTVLWRTENVDEKSVKLSYHSPDGDQGYPGNLHVTTIYKLTDDNEIIIIYDATTDKTTPISLTNHSSFNLAGAGSGDIYDHIVTMIPDKYLELSSDLVPTGNILSVKDSIYDLTATDTPKSLGQIIKSDPNFDGFDNCFVISDKPQNPLKLVTKVLEPKSGRKLEIYTTQPGIQFYTGNFLEKSKISNGKVTQKHGGFCLETNNFPDGPNHPQFPNPLLKPGEEYHHETVYKFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIC3</accession>
    <name>A0A914YIC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17065.t1">
        <property type="protein sequence ID" value="PSU_v2.g17065.t1"/>
        <property type="gene ID" value="PSU_v2.g17065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF502">
        <property type="entry name" value="TETRASPANIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17065.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43228" checksum="0C60FF6669957D08" modified="2023-02-22" version="1">MGLFGALRDNVHLLKMFALCVFFFYILLVLSTFFLFILFYSDTSEGISAHSILLYSIKKYHTNRNLADFVDYLQEQLECCGVSSMSQGFRDWQLNEQYNCNASNPYPEKCGVPYSCCRRSVISEAAGSLNPLVPAMRSLQCWQNAQTKRTQDLETDIYVRGCLQPVRTLFESHAVHLGAIVAVFIIPVCFSVCLSHLLARQIDYQKYLLDREERQFKRRQNRERQRLQHIDKKQTRVIEQQQHPIPPPTSTIPSGPPQIINTSLPKKSVDETSKEQQQKRHKRRAVSTSPLRVNATNSVSIIPSGPEATRLQQPSAISPRKQHKKRRRSLIPSGVGNGGGGLLPNGATNQPPHPQILSTTNPSDFRTHQWVLQQSDISGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIF7</accession>
    <name>A0A914YIF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20123.t1">
        <property type="protein sequence ID" value="PSU_v2.g20123.t1"/>
        <property type="gene ID" value="PSU_v2.g20123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20123.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="29417" checksum="CB0960CFFF4D7D87" modified="2023-02-22" version="1">MDDVYDSAPKTPPEIDNDEESDNPLFEESSNKTKRKENPTTPLTGNDMASSSKSNSNQTDPGPSSSTSERIKKKKSSKGKHKSSRHKRHSSSTSKRAERERSTSRSKTNEQRTTSNTKNDKSGRDTALSEASESSRAANATEQSSSAKDKTSEALITSDETLLEKSTNDATTTPRGVTVTSAEKEKSKAKDNSSSASRTDKTIHLNFPETSVNISSAATPVENPRTNATDEVSSLASNSVTISSTPTIDSLSPPVTTSSASNSHGVSQESTYFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJE5</accession>
    <name>A0A914YJE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19630.t1">
        <property type="protein sequence ID" value="PSU_v2.g19630.t1"/>
        <property type="gene ID" value="PSU_v2.g19630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19630.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28125" checksum="710EA00B45E55DAB" modified="2023-02-22" version="1">MYRTISPLIKSIYCYEPNCNHRCGRFHKSSSAGRPRPKPPRKPSHSFDIPTTSALDIDTTHRLSVTASHANPTSPFSTASTITLDDIIASARRKTSIDFQPIVLPSPVFLDELPSQEEPYFRTDSKSSMEGINELEDEFVQHLIDSDSEEEFWNNEPTSLIVDDELADFEELLKATQQPQDHYSNPTDRPADPLKRKRKKMAKQNDEDSSSIELSVADIDPEVLSLYNQQFTALTTTNFNKVEYEGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJN8</accession>
    <name>A0A914YJN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJN8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20551.t1">
        <property type="protein sequence ID" value="PSU_v2.g20551.t1"/>
        <property type="gene ID" value="PSU_v2.g20551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20551.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18248" checksum="DD10FB1836D113A7" modified="2023-02-22" version="1">METTNLDYSVNKLCISYAGISDDDGSQVYTDDEEDASINPTLKYSSIKAIPKETVTKKPESISDDDDSQLYTEDEEDTSINPTLKYSSIKPIPKETVIKKPESSESESKSSESEADDAEMKDPFKFGDKDPFKKSRSNEISCEQFITPCSTLPTIPITEVTSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJZ7</accession>
    <name>A0A914YJZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17628.t1">
        <property type="protein sequence ID" value="PSU_v2.g17628.t1"/>
        <property type="gene ID" value="PSU_v2.g17628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17628.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="41160" checksum="3C85C13D7CD9E3E0" modified="2023-02-22" version="1">MERNGTRSKKNCLDYRPKDLDPLVTIFLKFIGKEGPNNEIVQAETKKILHQWVRTTRHRQKDHDATNMNVITPKSVTVTKTARRKRKAARSNETIESLALQAQNLIPDLSKILQLFRRSSSLRFDWMENTAGIDIHSVLNTFSVIKMFPKQLIDVDYVELCVNKKWDIISIVDEMQRILPALKSLLQSYNVTTLPAHLNQNDLFANIFFSFPNLFHHFLNNSKKIPKPFYFESAAQDFLTGVNRIINEKQVQHNFFGRIETPAGQIIFAYINGHIFRIEGSLLEALEFYYRIHYVFRIDRPASIFFLTSWLDLLCKKKVETNCGPQRFMLEIERLCKQYENFPDSRNSDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK52</accession>
    <name>A0A914YK52_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YK52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19908.t1">
        <property type="protein sequence ID" value="PSU_v2.g19908.t1"/>
        <property type="gene ID" value="PSU_v2.g19908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="7">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19908.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13044" checksum="A72F39C74C5ABD18" modified="2023-02-22" version="1">MADVAEVQRAYDNKEVELQTRLTVRIEEFEKGEDGEWVKTIKRYETTAGRALLSEILPKGMPFTALNRALKKKEISRLINQSFRRCGLRATVIFADKLMQSGSVWQLVVVFPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKW6</accession>
    <name>A0A914YKW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Doublecortin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKW6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1999.t1">
        <property type="protein sequence ID" value="PSU_v2.g1999.t1"/>
        <property type="gene ID" value="PSU_v2.g1999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1999.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="52775" checksum="102E447DA95C4E8B" modified="2023-02-22" version="1">MMKNPYISQYTPNVYDPYNNISFLEINKARRGETHRSVEDRVYNRNYKPLTAKIYIRRNGDHNARLKPFIWRIWQTPKLENLIDEIASHLDMNGSDATLFDARGRIITDSTEIYDGGTFVLGQHEAFDGQIIEAANGNIASARDSQYQQQQQQHYQDYSNQRSNYAPLPKKKITKKKNQYDSHNNYSRPQSSNTYGDLTEIYSVDQGHRDMPEIATSDFGNYDIYRHDYDDEQNHRRNEQQDYEYDEVPWGDLEDINQKDKHMLSKHRQKFGIRRSRSAVIYNRKDQTNPDAYIIYAFLNGHGLECQFVNFNRKQLEKGLPFILELVARKFNVKPSKLVNMDGFKIRDVTELMSRGAYVLIPVGQSFRDTWYFLPDNAIDTSNDVEKVRARSAQRDRYLQKQESKQIKQTKMRQSVASKRHRSAGPFTGYTNQQNHRTYSVDPRYRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLD7</accession>
    <name>A0A914YLD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18134.t1">
        <property type="protein sequence ID" value="PSU_v2.g18134.t1"/>
        <property type="gene ID" value="PSU_v2.g18134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18134.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21475" checksum="FC0A2BA0C80C5170" modified="2023-02-22" version="1">MKLDRQAYVPYSVLLKQHEEAQKLKEVLDTKVTGTVKWFSLRYHYGFIARDDGKGDVFVHQMNITKSRMNRVYLRSLAHNEKVEFDVVEGKSGPEASNVSGPDGADVQGVYVIQLRYPRSSFNGSRRRNTSRSQGGGNSPQSGDNRRNGDDKKAVKSSEDNDENKPRPNKFNGTRRRRNTSRQPRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLG2</accession>
    <name>A0A914YLG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLG2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1974.t1">
        <property type="protein sequence ID" value="PSU_v2.g1974.t1"/>
        <property type="gene ID" value="PSU_v2.g1974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1974.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="8398" checksum="B4AB9E7EEA908CC7" modified="2023-02-22" version="1">MWSILFVTDARFPGAGIDGGGLTTLRTLTGSLRRAASNTPKLVKYRPLARSQSSLTSAGCGSVSSGSIAASIGSVPGMAIELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMY4</accession>
    <name>A0A914YMY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g203.t1">
        <property type="protein sequence ID" value="PSU_v2.g203.t1"/>
        <property type="gene ID" value="PSU_v2.g203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF222">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g203.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32012" checksum="95F981EC5D5A3FE4" modified="2023-02-22" version="1">MCCQKLESRCKFKYNSYGEGFSDGALEYLRKRITWATKPHIKSNFVTINIFYRDMAYTQYEQMQSTTFTQVMSNIGGNMGMTLGMSLISIIEIIVYLSKTSWIFLSKKRREHLVEKKHYEKQREQTLKQTLEKAQQESSPHTFRRIANSIRRKVSQVWPKSPTQPKPNSSTFFSSQLVDANLRGDGKITIGNEPIFAEVKVDADQILEILQENKFGRPRSVSCPRTYSRGWKPNEIILPTISSSSTIAITDSSKSSCSGTSSSSFDNEKHDLENNCKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNC7</accession>
    <name>A0A914YNC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18838.t1">
        <property type="protein sequence ID" value="PSU_v2.g18838.t1"/>
        <property type="gene ID" value="PSU_v2.g18838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18838.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="12948" checksum="D0C20B434D17CA71" modified="2023-02-22" version="1">MSKLTVITDRALERALELAHTAGDGLKSAGGSLRNADWIKTGAAIGTVKTGGKAATKFVRRNPAVAVAAAAVGVGLLGYALYRKQQKKKAANGHVVNGQAQRINARDRRNDTVVDEHSDIGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNF5</accession>
    <name>A0A914YNF5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNF5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g240.t1">
        <property type="protein sequence ID" value="PSU_v2.g240.t1"/>
        <property type="gene ID" value="PSU_v2.g240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g240.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20815" checksum="7FC284AA4618DB96" modified="2023-02-22" version="1">MAPKRIQILTESKAGKAALRKLAAERERKKAKSDPQLALALEEKKRRKAEAERRRYNLSRSQVAELERQKNRRDNNGLRQIYIDESSQSQVLSNTSKQQRRRSDPVNYNRDLQLKRLQNQRRSLGSVSSNISNSSGQNSVSQATAQSAKSVENSQAGSFHTSDENSTRTQVTTRSSESEQGKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNR0</accession>
    <name>A0A914YNR0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNR0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18988.t1">
        <property type="protein sequence ID" value="PSU_v2.g18988.t1"/>
        <property type="gene ID" value="PSU_v2.g18988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18988.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13121" checksum="8AB615C642A02E6D" modified="2023-02-22" version="1">MKKRQSSSRNQSSSPTSESSLSPSASPSPELHHHHHHHHHQNENIPFNCSSKSSSEIIPDNSSSANNSDDPQPSTIAEADRVEKMQLAKLQDRKSRIRYEASSQCPCCGRITPGSKHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNY0</accession>
    <name>A0A914YNY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNY0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21326.t1">
        <property type="protein sequence ID" value="PSU_v2.g21326.t1"/>
        <property type="gene ID" value="PSU_v2.g21326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002606">
        <property type="entry name" value="Zinc finger protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="615"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="695"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="911"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="958"/>
            <end position="992"/>
        </location>
    </feature>
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        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="747"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21326.t1"/>
        </source>
    </evidence>
    <sequence length="992" mass="114982" checksum="6A76A3D960E36A5E" modified="2023-02-22" version="1">MATRIMALPISTKDGNAGLNPMSFTNHLTESAFERLRIQRSDGKFCDVDLVVKDKHFPAHRNVLAACSPFFESIFRSSKVLKEKVSVRFDDPEVFEILLNYMYGCTITIDRKVVSGLLVLSNNLMIVRLKHNCIEYLNKYIDNANCLFIRDISDRLNLPDLTKKANEYINQNLNGCLMESVDLLDYDLNALKLFISDARYRNVVESVTYLKCLIRWTNHNLNKREKEFYDLLEMIDFNTIPIETLYEIIETSVLFKSSLKCLLDILHSLFESNIPLDKFEANYHQLVRACQDKKLLYVSKDLVDSHFLAYENDEGMPHPMEEDDEDSEIDEIMADVHNNGGEHDSNDVDRPRLKLKINLGSPRKNLIHGPRRRGRPPKARTQRAEGDIENVDEEPDERFFQFNEDQQGIATFDEPDEFNPENTIGDNIDEEFNQNAENQDQENATEYSCEHCVFQTFNNTKLKKHVAVAHSRNVLYVCNICGFECKWNRAFYEHVKTHFPGPPFQCDSCEYTVDRIHVLLTHRLTHTDDRPFKCPQCDFRCLFKSNLIVHHRLHSGEKPFHCPECNKAFAMRYSVQKHMVIHSTDRAFACEECDFTTKYQSHYIAHRRIHSGDLFFCQQAGCTYSSPKKSQLAAHLRTHLAVRSHQCNTCKRTFIEKSHLVRHERIHLEEKPFKCENCDYASSRRDKLKEHILKHHTAQQSPKTHRRRFRRAKQVAQLAAQARQPQAACPPATNPNPENFFQAIPHQPSSSTRQPTDSTDFVPQTSDNSNQFRPQMPPNAPTQSVFVDQEQREYAIQQVVHLSQPPQEQSNTNFAAHNPPIETQTITQHRSNMVIGHDWQPLTLNRPASETLQQNQLNAVSPSPSLNFDLQVPPDNFYQRINPTNETIMRNPQSLGRDDHYFQHKDDMVLSMQPDPHVSDPQRPLSLPPSYGAQPYYSMTDTNQSSLQQQFIIASQQQHPVVIPQQQQQQQSSQPSTQQQQQQQPSNQWWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNY3</accession>
    <name>A0A914YNY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatase and actin regulator</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNY3"/>
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        <property type="protein sequence ID" value="PSU_v2.g19066.t1"/>
        <property type="gene ID" value="PSU_v2.g19066"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19066.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10471" checksum="7C6CBBC26DEAB9A3" modified="2023-02-22" version="1">MEQTRKVLLRKLSFRPTISELKDKQIIKFNDYVEVTEAEMYDRKGDKPWTKLTPAEKALIRKELNDFKATEMDVHAESRIYTRFHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP35</accession>
    <name>A0A914YP35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g21395.t1">
        <property type="protein sequence ID" value="PSU_v2.g21395.t1"/>
        <property type="gene ID" value="PSU_v2.g21395"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21395.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="11774" checksum="6DF6EFBC5822EB25" modified="2023-02-22" version="1">MPLFGYPRRGPLVGRAGAAAGTDPDRVRLHHADVPGGTAXHGEMATRRAWRDPGGGHPGTGEVGHRRLSGQLPVLPEAVWHGGLRADPAAVDLPVLGGGAAGRVAGLIDGGLPLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQT5</accession>
    <name>A0A914YQT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQT5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3146.t1">
        <property type="protein sequence ID" value="PSU_v2.g3146.t1"/>
        <property type="gene ID" value="PSU_v2.g3146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3146.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13879" checksum="1881EEE0478BD180" modified="2023-02-22" version="1">MSMLVKDGDKCIGYHVVDKIEKDNFDSYFTNGSYMENPHLDFKDNYAEDIKNGPFNSHKANTIATLLDAPFAQTLRFLPKDVNCLLYFEVVGIDKNYQNAPKKGVVIFGDDNFGDLDFGDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR95</accession>
    <name>A0A914YR95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR95"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2174.t1">
        <property type="protein sequence ID" value="PSU_v2.g2174.t1"/>
        <property type="gene ID" value="PSU_v2.g2174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038825">
        <property type="entry name" value="Apical_junction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517:SF3">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2174.t1"/>
        </source>
    </evidence>
    <sequence length="533" mass="66475" checksum="0D1680C95259E59D" modified="2023-02-22" version="1">MEEEELARRRERERLEKEKLERQQMEAERIERERLARERAEIERLERERGDRERIERERIEIERLEIERIERIKREQREKEHRDRERERLEIERLEKERLEAERLERERIEREKIEREIIEQQRREAEQREKERRQDEMREALRREHEARERELIEKAEREAAEREHQRRLQEKLEWERLERLRGEQERLEREKEEAARRERERLEEERRERELLEAKIAADKRREQERIEEDRREMERREQERREREKRERERLEAAERERDRRIEEQREQERLGELERKAAERRALQAMEGQRAREREELERERLRLIEIEKMEADRREKERLAEERRLAELREQERRNAAVREQERRQAAEREAARQRDDRRSRERLDIIVKEREDREKLEWERRRHLAEKEAELKRKKDLTSKETLERLTRKPYYSRENLSSLGGPEITTKVERQVIERVDRTLYTDGGPLTSTSYYTGGGSSINPPLSLEAPTDEFGLGRDRLFQSRNDDLRDSKRASRYKSRLENNNRARRDFFSADSSQNGESIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRC5</accession>
    <name>A0A914YRC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2564.t1">
        <property type="protein sequence ID" value="PSU_v2.g2564.t1"/>
        <property type="gene ID" value="PSU_v2.g2564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF1">
        <property type="entry name" value="FH2 DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2564.t1"/>
        </source>
    </evidence>
    <sequence length="457" mass="54014" checksum="5F8742FB3AB175FC" modified="2023-02-22" version="1">MAFNLIWQNNRLQYVFGGVLLDREHAYTVDINGDVLHIFREKNETFYCSNIELLVIRDGYVSKSHGHHHNARQQQHHRAHGHIFTPDDSLSPPCAGPCNLTRPPYEYVEPPPAPPKVEPPVPPIVYVEPSPPPPRVHIKPPPAPPQIYIEPPPPPIVVVEPPPQRLPPSIITNDCDEWKIQIQKLRMDLEYKDGDFLDCQNKYKYYESEIQKLKNGQTFNSNEYFSIQRENENLRQQISRHRKLENEIEQYKIQISQLMVFKETVTRLEYENEKLRENLRISESQKVETETYHRQKIVSECEKKYLESEKQLKFVNEELSKEIYRSDNAENEKDKCENKVKEYSRKMNDIEKQWQIKYNSAISSQQQRLLQQSPPQKYFGSCNPEEINLLKQKLLTEERKGKENIAELQRLRSKFVNIQESKILIENQLFVLQSEQKSCNQSLEEARRKLFILQIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS45</accession>
    <name>A0A914YS45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-soluble NSF attachment protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YS45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20217.t1">
        <property type="protein sequence ID" value="PSU_v2.g20217.t1"/>
        <property type="gene ID" value="PSU_v2.g20217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20217.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31252" checksum="F318C9FCBE0D3474" modified="2023-02-22" version="1">MTDNEAKARGFFGLFGGGSVDDTANLYIQAGNLFKIAKNWGEAGKAFEKAANSYDADGKHNSAMQFVEAGNCYRKADPEKAVQMILRAAEIYTDMGRFAMAAKNHISVAEIYDTEAPNMEAAMKHYAKAADYYKGEEQRVTAVKSLEKVGMYAAQLGQLRKAIETFEEIAFYQADHSTLKYAAKNTFFKALLCHLNLDTLDTTHAVTRYEERDPSFADTRECKLIKELIQAIENKDADAYTAEVTKFDKMSKLDTWATHMLLQPKKSIAPAVIVDENDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSZ0</accession>
    <name>A0A914YSZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3118.t1">
        <property type="protein sequence ID" value="PSU_v2.g3118.t1"/>
        <property type="gene ID" value="PSU_v2.g3118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3118.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15369" checksum="C7E7C9B7AB18A72C" modified="2023-02-22" version="1">MTYMHKNGFFHRDMKPENIMCNGIELVKIADFGLAREVRSRPPFTDYVSTRWYRAPEILLRSTNYNSPIDLWALGCIMAELYMLRPLFPGTSELDQIFKILTIMGTPTQEEWSEGYRLAAAMNFRFQQCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTD5</accession>
    <name>A0A914YTD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTD5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2929.t1">
        <property type="protein sequence ID" value="PSU_v2.g2929.t1"/>
        <property type="gene ID" value="PSU_v2.g2929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2929.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14517" checksum="FF75638CB38FA8CD" modified="2023-02-22" version="1">MYWRCWLDSSCSATIITDLNYELKNRGQTHTYDPNPLEVEKRRLLFNIQRRAADTVESTAHIVTSIRSNAAEPILIALPSHEALAQKIQRQRRKERGVILDNTIDFEIPPHLKVYERTNDQFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTI8</accession>
    <name>A0A914YTI8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YTI8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2982.t1">
        <property type="protein sequence ID" value="PSU_v2.g2982.t1"/>
        <property type="gene ID" value="PSU_v2.g2982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF10">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE ACL-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2982.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24651" checksum="3BEE9B187790CDAA" modified="2023-02-22" version="1">MYKVYKKVCAWTGIKYETRDLKYLDTDEACIVIANHQSALDVITMGYMWPQNTVVILKKSLKYLPGFNLCGYLCHSIWIDRINKEKAHKSLDDAMDHVKNKKHKVFIFPEGTRNSNDEMLPFKKGAFILAKEANVPIIPVVFSRYKNFYNHDERRFDYGGHVIIKSLKPVYPQDFSTIEELSDECRKLMTAELDRLDKELIDEEKSSSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTS8</accession>
    <name>A0A914YTS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Insulin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20853.t1">
        <property type="protein sequence ID" value="PSU_v2.g20853.t1"/>
        <property type="gene ID" value="PSU_v2.g20853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00101">
        <property type="entry name" value="IlGF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036849595" evidence="3">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="4">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20853.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10948" checksum="13714029586ECD67" modified="2023-02-22" version="1">MRNSIFTITSFILFLAAVCAVVAAKKYCGTELNRMVAKTCVFPGETQPCLGSSAMTNSNVQQECCQKGCDLKTIQKLCCFTEKCLNDCYPGKGHKMGIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTY8</accession>
    <name>A0A914YTY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine diphosphokinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4124.t1">
        <property type="protein sequence ID" value="PSU_v2.g4124.t1"/>
        <property type="gene ID" value="PSU_v2.g4124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="5">
        <location>
            <begin position="168"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4124.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28344" checksum="695D7FECC76E25BD" modified="2023-02-22" version="1">MFKVMSVIDFSRCLSPSRAIAILTNSPFALLPAKWQEIWSKAAFRCATDGAANHLRPFCESQTGLKLPHLVSGDFDSISDHTKKYLSEKNVEIIETEDQNDTDLTKLIKLVCDRKDLEWDAIFILGGFGGRFDHTMASLNSLLKSHEWTSKHVFLLDHENLTTMLHKGQTKVTFTNFTSSLFSKSCGLIPIVQRETIVSLKGFQWNLDKFSLEFGGLISTSNNIVLEEVEIETNEPLMFTLEADWKMFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU62</accession>
    <name>A0A914YU62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VWFC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
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            <begin position="371"/>
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        <source>
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</entry>
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    <accession>A0A914YUM7</accession>
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        <name type="scientific">Panagrolaimus superbus</name>
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</entry>
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    <accession>A0A914YUN8</accession>
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    </dbReference>
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        </location>
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            <begin position="19"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3384.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23594" checksum="9F7B6124AA2998F6" modified="2023-02-22" version="1">MKIIFYIYCFLMIQIAAAAPTKIFENYEGLDQTNLINEKSQKIRQCTCSEADECVSEAYPSLKECRKSCKSYLEYFGAKTNDYVECWPSNPAGKDLLISCLKKNIDGFCTTNSSISYIDKPEYNQTAIEEEDESNFEMAKHFKAFHYCAGACLKEKIVACYERKSCGVLIPQNYDIGKPANFCEDLKSTVVSNTFKAYACIAFSQFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUW9</accession>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <text evidence="1">Belongs to the peptidase S28 family.</text>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3465.t1"/>
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    <sequence length="77" mass="8676" checksum="476B4EF4C35A3DED" modified="2023-02-22" version="1">MSNFEILQGTKVVFPNGTNDPWHVLGVLSPTNDKTYPIIIDGASHCDDMIPNPKTDTLALLEARQKIRSYVLSWVYE</sequence>
</entry>
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    <accession>A0A914YV41</accession>
    <name>A0A914YV41_9BILA</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
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    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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            </authorList>
        </citation>
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        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
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            <begin position="64"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="483"/>
            <end position="622"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4010.t1"/>
        </source>
    </evidence>
    <sequence length="865" mass="102221" checksum="DFB5B8CFB4F30C6F" modified="2023-02-22" version="1">MARMSEKICRARYCVPLSIIIVAVHFALWWYVIYPYLIGSTDSIILSDKAAEFGPGYSDTAYLNSEDASDSGVTNYDGSREQNTTPYETTSSSSHEYGMIQSSSVENLRQETRPREIPRHQHRYRHRNHNHRHLYVVRRKKPLNFSSSTTPPPSSYTTERRRILENVNTRTQQPYQQHQQQQQQYPWGSRTFPPRISPSTTVNPTTLLTNFVAHVTTTKMTTQHRSHHDQRQQHKHRHHHQHHSTTPSTTPPSMITPQFRHHHHFEKERNEELQRQREVIEREKERREQERMKQLTEERAKLQLTKEQEQRAQAIYESQQRALKERKEEAAARKKVMEEESRRRQEHERKIQQWNREEQRPEEGAIPRRPPPSVHESNQWHHPRPLEGDQQQQQQQNQRQNIVDQRSQQQKSAETVADPWAHLRQIEEQRSTSYTVAPATRSPGTFSNEIDPFSITSHRIEEASGVWRAHVDHQNLHPNAISHERHHHQHQGHHRQPNPQPIPQPPPQRPSEANTRRKMIEEEKQRQQEYDRRMQEWNRQQQQQTPRQNPTPLSPPQLPQSNEPLPPPLQPQHHHHHTLQGSILPQQIPRHGHHQSHQSSSQNEISNEIAPASAPPANREKRDTAPVIVTALLDIGRGDWFTFTRPYDLYLNYLLDLLKLQNRIIIFGDRQVFEFLEQNKDIIDFDRIQFVELSLDDLPYSRYRNEIKEIMDEEQKNWKTDWEKATKTHPEAINPDYNILVNSKPYLLFNATQISKFESEYFIWIDAGYSHGEKNIIPSILWNPVLPPGRITVIKITPDQDKVTNYAVEHVYRKAWTVMSGGILAGDSSTIDRFHRFYYKTFMDLLDARKTDDDQVCLFIYPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVN4</accession>
    <name>A0A914YVN4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVN4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4044.t1">
        <property type="protein sequence ID" value="PSU_v2.g4044.t1"/>
        <property type="gene ID" value="PSU_v2.g4044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4044.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14827" checksum="1FFA37D5A2D3FF1D" modified="2023-02-22" version="1">MTDVVTVRTRKFMTNQLLARKQMVVEVLHPNKVCPSKNEVRENLAKLYKTTSDLIVAYGFRTVFGGGRSTGFALLYDTVDSAKKFEPKYRLARMTGTKIEKSGRKQRKERKNRQKKLRGTSKAKVSAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW27</accession>
    <name>A0A914YW27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW27"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2287.t1">
        <property type="protein sequence ID" value="PSU_v2.g2287.t1"/>
        <property type="gene ID" value="PSU_v2.g2287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2287.t1"/>
        </source>
    </evidence>
    <sequence length="472" mass="54301" checksum="9F41D96D0AA93C53" modified="2023-02-22" version="1">MEDTPDGPKTSTPVYALYSSTSPRVIYANSVKEVRAHLSTPELRNSDTRFKTFQNVEESEIYFSKNPVSKMLTPSGMHTRNEDGYRSPFPKLRPQELSKFLKSIQAQKNDEAIEYMNRNPHYFIDMSIDQPSVLHIGCRHNALHICARYDNLFIAMEIMKRIRDLKYIADIYNTTANIEETSAILIDRFLNNPDKTTRRTPLLWAARQGFAKLVMYLSSFPEAQLPDKDQIKDVQCQFHERDEHVPKCDRILDCLRRPSKTYCITLYKESNDEAMPFIAITTRFPHPSILENQKQFYFKNVPASTFTGRVEDGITSVRISKFLGGRYLSCGQPIDGLNTMPRFVPYASLGVFGEKWITAIFYQMWAAEFKKMRRNPAACRDYLSNVAVRLADANGYFVYYANISGIIIPEKKYDQFRYKLQSDDNNDAEEALLKALENLSVSDNKPKHVFNFAELDDSEDNGNFSTAPSSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWR1</accession>
    <name>A0A914YWR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dopey N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2520.t1">
        <property type="protein sequence ID" value="PSU_v2.g2520.t1"/>
        <property type="gene ID" value="PSU_v2.g2520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2520.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="26503" checksum="18B107672C902A50" modified="2023-02-22" version="1">MSDLPLSAYEKDIFLLQSSKRYQIYVRDIDKALYSFECFEKSIGWANFIISLTKLLRVLQIRSKNFPIIPKSDLIARRLSNSLHPSLPVGVHMKALEIYKQVFVILDRADILQSADLYYYILGLFPLMEYCGVRVKAELLIVFEKYILPLCDKLKSETPIIESSFFSSVRHQQFSIPEHIVYYIIKNYKKLDVYEKLIETCKYFFINNPINLNKFIHLIVLNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXE6</accession>
    <name>A0A914YXE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4320.t1">
        <property type="protein sequence ID" value="PSU_v2.g4320.t1"/>
        <property type="gene ID" value="PSU_v2.g4320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4320.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13537" checksum="D1B6CD1573AC6A7A" modified="2023-02-22" version="1">MTDQKPKRSYIRPDYDTDVLWRPMRPMMTRTRTISTDSADSEIMASSPRERRFSITGMLMGASAGIGGLVRQGSTGSEVAPPKKLSLSEHVDFKEFMRRQNRALSDEDGFRSKDYTVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXJ7</accession>
    <name>A0A914YXJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPGRIP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXJ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5221.t1">
        <property type="protein sequence ID" value="PSU_v2.g5221.t1"/>
        <property type="gene ID" value="PSU_v2.g5221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021656">
        <property type="entry name" value="C2-C2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF1">
        <property type="entry name" value="PROTEIN FANTOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11618">
        <property type="entry name" value="C2-C2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="146"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5221.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37820" checksum="6708E0CF062EF012" modified="2023-02-22" version="1">MTLRLKKLTITENGLKHTSSIDPMLFLSLEFFDFELQTTPLIQGPESVFEYSTVYDILISNLFIHYIETEGITIELFEVKGVAYDQKGAGIISLKKLLETETPAMISGKLRLFLPGSKETVMAQLEYQLEVPFSLIKALKAQKRRLTASSYLPLDSSIPSTLYNEIEILIHRCSNLQVLTKSKQLPSTYVAYQIYDLQPHLTQIQSKNANPVYNDSRAFTLPIGMALHRYLKTEELQIYVVEENSERANRGKELGSIILPLFPLARNQSIKGTFSLTTSDGQVSEATIDLSIYWKYAYTFNDENVEVEEPVSEYDIQIFDYCKVIKSFRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYC6</accession>
    <name>A0A914YYC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pao retrotransposon peptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYC6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3063.t1">
        <property type="protein sequence ID" value="PSU_v2.g3063.t1"/>
        <property type="gene ID" value="PSU_v2.g3063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3063.t1"/>
        </source>
    </evidence>
    <sequence length="451" mass="52534" checksum="BE0833B0F84F19E2" modified="2023-02-22" version="1">MFLLFDNPEEGTEQFKTIKDHFLKASMKIREWLSNSSQIMEIIPDELKQKSFIAKVLGLEWDSKNDTLQLQLRNESKVEKWTKRSVLKFIASTFDPLGFLSPVTVQGRAFMQELFKEGLTWDEPLPEKLLKVWQPVFSDWNGIVKIPRRLTFEKFPDAKVIEIHAFGDASQTAYCACVYLRIPTSSGYVTPLVFAKTKLQPLNKILTIPKMEVMGIWLASKISSFVAKELELEVSQRFIWTDSQISCYWFQKHPKDVFVTNRLREVLETRSELMFVPGKLNPADLGTRGVKFEELLKADAWWKGPGFLRKSPEKWPKFPKLDSDLTQTVTAFVAINEFHFTTVLQNVEVQREFDVNSNESWASLKRAVALQLYPNKTVDLLNAKELELAERAIIAQEQQFFLTSKLEKDFKLLKDDNNLYRIHCRFDHADLRKVLDTVWKNDCEKVFEKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYI3</accession>
    <name>A0A914YYI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g5010.t1">
        <property type="protein sequence ID" value="PSU_v2.g5010.t1"/>
        <property type="gene ID" value="PSU_v2.g5010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000100">
        <property type="entry name" value="ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000081">
        <property type="entry name" value="Protein CBG24505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001792">
        <property type="entry name" value="Putative abc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF342">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="983"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1125"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1219"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1246"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="335"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="649"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="993"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1313"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5010.t1"/>
        </source>
    </evidence>
    <sequence length="1553" mass="175259" checksum="BCF740E10E1A0D3C" modified="2023-02-22" version="1">MLDIETLPLFSQCFQHTILVWIPCLFLFCLSPILIFQITLEKNSPLPWTRLLLTKLIITLLLLIDAFSLLILALYESITVDITYTVDFIYPLMYMFLMFLISVFIVACQRFGKVTSGGIFLTWILLLICGLPEAYWWLSQNTHPSKLTLNGTPRFILYLIWYSLVAVQVILFAFADKPGQDVYKRLHKQENDSPEKLCSFINRQTLWWFNRICAIGAKKPLEVSDLYSLNPDDTSAVLVPRWSSLWDPAVKNFMNKKKEAELESRNNSSRRGSATINGGATGTTPLLSANVDRIGLDYDYGTVTPSPLSLPAKVPSPPSIIWRLFLMFKWDIISAMSLKCISDLLQFCNPLLLKHLIAFTEDAASPLWVGVFLSLCMFTASELSSLLLNHYYYLMYRIGTRVQTCLTATVYKKTLRLSNGARRDRSVGEIVNLMAIDIDRFQQITPATHQYWSTPLQISIALFFLWQQIGISVVSGVAVMLLLLPINFFITMAIRKSQVAQMKVKDNRTKMVNEVLNGIKVIKLYAWEPPMESVITNLRNKELALIRKAAFLRTLSDMLNCASPFLVALCTFTTFILLDSKNVLTPQIAFVSLTLFNQLRTPMSTVAELISQTVQVFVSNRRLVDFFIADELEDYVEKIPTDSRDDDIIEMKDASMAWDREIGVPSLHNININVPKGQLIAIVGKVGAGKSSTLMSLLGEMERLRGHIGVHGTVAYVPQQPWMQNQTVRHNITFGKCFDEYFYSRVMDACALYQDMSILPMGDITEIGEKGINLSGGQKSRISLARAVYQNHDVYLLDDPLSAVDSHVGAQLFLNVLGPEGMLRNKTRILVTHELSYLRYANLILVMQDGKIVSEGSYAEMIKSGEFSELLEECKVQQEDQLQKQKQEEEEIAYSSEEDEEPFVDESEFGENLLGTSHMSTVSGIISRRRQYSVSHNKVKRRRHSTVASLISGTDIQHRQLTGIERVETGRVKLIVYARYFKAMGLILSSFFVFGMIFSTIASMLRNLWLTDWSNDNAASIASNSTGQTHPIGIRLGVYAGIGFSEIFLMFLGMTSLLFGGIDASKNLHSPLVRAIFRAPMRFFDTTPFGRILNRIGKDIETIDILIPYNVQFFTQCILQVTSTLIIIIISTPIFGVVVIPLAIMYLFVMNYYIGTSRQLKRLESITRSPIYSHLSESINGSATIRAYNLVQKFSRISENKVDTHVQCRYLNYVANRWLSVRLEFIGNCVVLFAALFAALTRDSTSAGNIGLSVSYSLNITFVLNFAVRQISKLETNIVSVERVKEYSETPTEAEWRRPGKEPPRDWPSEGRIVFSNYSTRYRPGLDLVLRGVNAEIGAHERVGIVGRTGAGKSSITLALFRMVEAAEGSISIDGINIAEIGLHDLRSNLTIIPQDPVLFSETLRTNLDPFGDFSDAELWDAIDKSHLRRLVEEFPLKFDQEITEGGGNLSVGQRQLVCLARAILRKKTKVLILDEATAAVDMETDHLIQQSIRTQFPKCTILTIAHRLNTIMDYDRILVLDSGKVREFDSPRNLLSNRNGLFYSLASQAKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZR1</accession>
    <name>A0A914YZR1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5421.t1">
        <property type="protein sequence ID" value="PSU_v2.g5421.t1"/>
        <property type="gene ID" value="PSU_v2.g5421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5421.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13715" checksum="91541516DF5D32BE" modified="2023-02-22" version="1">MLFTFLFFRIKAIETPHKDDDTQWLTYWVVFALFNVFEFFSDMITAYFPIYWFAKWIFLLYLHLPMTRGAEKLYSSFIRPFVLKHQDHIDKAVGKVHEAADSARNAYHQNVKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z291</accession>
    <name>A0A914Z291_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z291"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6479.t1">
        <property type="protein sequence ID" value="PSU_v2.g6479.t1"/>
        <property type="gene ID" value="PSU_v2.g6479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038008005" evidence="2">
        <location>
            <begin position="26"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="659"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="787"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="888"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6479.t1"/>
        </source>
    </evidence>
    <sequence length="1085" mass="123086" checksum="71DA6C2D0CBAE6AF" modified="2023-02-22" version="1">MKKGIFPNFITVVTLILYCFSVISATETDENVDFPELYSRKSGAETYQIYRNPQSFQTDKVDEDITKNDSLLLFDKTKAKSVQLEKIKSDEYIAPQRYEISQSDRNESNRIHGIKQHQLSDSNSNEINETNLNVENKYDNFGDRYQQWNESLYHQAQNNEKVDTLNPYPPLPLKHKDSEPEYFPPSFKQTLSENETPENEKEKSFSISSSLRDSTRTTVSPNNSNRNIEDITSPEMEDYDKNGMLAKGEEVQYSDDSTPSRQTYSTEGIKRDRTMPFKVTHSLMDAMDSITQPTTYLQDSEATIYPTLVPEIIDEEDDQQENSEEEDVKKEEGALITSDYISNMEPSQRDRMFSRDNLQPWERHRNEVLEREQHQKEENEQQSYTSHSTSSNSIETSTIPYLTSYLVPASSIYAAPAPPLSSYILVPSGTKYYGDQAPKIQTISDSSYDRIYDQDNSNDNNNNGFRIKQHKISRENIVTVEKVEENENENESSSDLSRSPQFKLYGIKTAFHKGSGTTEKNETKVEKYDTWLANPATIFDLPLPTILKTAFAVNTKAFAAKQHSENSNLQNEFELDESGNPLKYRKKGNGYSTEISVSPLRELPDFEVISGGESEGKDGQQEIDTFVDEKALEAAKKDSCQPLELTSIQSEGDKLLSQCFVIAKNCLLTNAAPIERRINLNLTECATFCSENQYCKSIGYSETMAICDIFAFLNGTSDSSLIRYHGTHYLQPTRKNIKKCLQDDRHLNGITVVASNDPIAVSSNELSEEQLLSLTNKANSNVKLNSCPIDTDILTLKTENYRLRNFGIDKFVQDPPNSESECIFSCLIDLANGRLPFNCTSASYNSKTNECTLYSGGSNVNGNGHLIEETNFEHYEKVCADDKLVQQCRGFPVERIPQKLLMGFVVSREKAASLLECITLCFERYKNHGDCLSVNYFYTEKYENCILSSESYLTIPQFFIDEVESIVDHASIDKCLLIKQDLIHVSTNGRIPQKSLAIDIEDGSRILPSTPGFDIVPTIDEERFNTNAIGDNTFLVSSKDDAEIRRHPLNVHRISSTTPLTPEIAAEDRQKLTNQLKKSIKKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2J9</accession>
    <name>A0A914Z2J9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2J9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6119.t1">
        <property type="protein sequence ID" value="PSU_v2.g6119.t1"/>
        <property type="gene ID" value="PSU_v2.g6119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037041634" evidence="1">
        <location>
            <begin position="16"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6119.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31731" checksum="16D5FA798C57B23E" modified="2023-02-22" version="1">MITFLILIFVGFGNAQLRYRPQEKYDYLTIFKDDQWEKVKCECNAPEFYVSCEDESILQPMLETDYFCFGMTCHYQIIFDPNCPDTYFTVFADYTFQKSKNILSISENPEYGPFFFPSRLIFSPMAKLFVRFDSLNMPHYDHQNKWKITFNPRPAPKKVQINLDLKNPYHLLWIDSMKSDEMITVCLADNNEAQKMEMKLQRRNDLSLIKFYNSNDMTQFVSSLNFEPEMSESTNVFTNSCFTLHQWFKPEPATKSFVLFKLFLVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2R2</accession>
    <name>A0A914Z2R2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2R2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6356.t1">
        <property type="protein sequence ID" value="PSU_v2.g6356.t1"/>
        <property type="gene ID" value="PSU_v2.g6356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43414">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN MDTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43414:SF6">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN MDTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6356.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27213" checksum="95675AB27564FD58" modified="2023-02-22" version="1">MPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAIASPFWGGLADRKGRKLMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASGDGLNCPHSDAWHDRLGARRGGSAKCTTTRQTWRSNRTRKDPDYSADLFCTAVDPNVLRSDAIATWDFTFFARCRRWCTTPRRTDTVGLQLEQPDRRAYLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2W8</accession>
    <name>A0A914Z2W8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 34</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2W8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7048.t1">
        <property type="protein sequence ID" value="PSU_v2.g7048.t1"/>
        <property type="gene ID" value="PSU_v2.g7048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026106">
        <property type="entry name" value="MAP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14739">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14739:SF9">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7048.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="34000" checksum="EE16513AF38659FD" modified="2023-02-22" version="1">MPQPNIDIQEQFQMVRQKQGERGAYTLWLEGKLEKEKQRKKEAKQKEEREEEEKKRKLQDASKAFERWKQDRDQQIREKKEKENQQKQKKLQKAEEDKEAKKREAEKLFEYWKQNKMSELQMDLAKRREKAERQKTRKQQLEEDKKEEAERSFIAWKEQHAEALRNMRQQQLREKEIRNQEAEELQLAKDQLAKDAFNLWMKMKEKQDNFERSLAYRVLQYESETSLKRTPSPWIPAGGRSVPRSTSMNSLRPKKERSTNSVKRVTFNNRSFSQSRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z424</accession>
    <name>A0A914Z424_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z424"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7101.t1">
        <property type="protein sequence ID" value="PSU_v2.g7101.t1"/>
        <property type="gene ID" value="PSU_v2.g7101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7101.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="10455" checksum="92E7169AE4716CB2" modified="2023-02-22" version="1">MGTRCSGRPAPGRPPGSALGGSADLQCGGIDAGHALDALGGGDRLVLLGLGGHGTAQADHAIHGFHLDFSARNVAAGQQVGLHLGGDPAVGHRSFESWRSAWVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4B6</accession>
    <name>A0A914Z4B6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ycf15</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4B6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7198.t1">
        <property type="protein sequence ID" value="PSU_v2.g7198.t1"/>
        <property type="gene ID" value="PSU_v2.g7198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7198.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="17128" checksum="C229BA174A15C096" modified="2023-02-22" version="1">MPTIFRLKLSELQDITKLLKPHLLDETLREYDSDKLKLIISEWLLLNDFSTLHLFEKNANYVWIHPKENQCDCCWKFRIGRRKLSFPSIDAVDKNPSPRESQMLYYGGPWVIASDENKPGKPKLRVRSHLLHTTYEKSVYIRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4T0</accession>
    <name>A0A914Z4T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CRC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4T0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6902.t1">
        <property type="protein sequence ID" value="PSU_v2.g6902.t1"/>
        <property type="gene ID" value="PSU_v2.g6902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRC" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6902.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27444" checksum="929BFDA7E08139E1" modified="2023-02-22" version="1">MENNILLFDDAKTRYPGRRFSVPLFENNNPYFESPVSSTARREYFFSSPARKYNKTFAKNSTERIRAIKATLDKNPTAFNSKIGVGKKRGNNDIERVHTIGCSCKKSSCMKNYCECYEAKVACSERCSCRTCCNTENDREGLICDKFPMINNEWDKNTTNDEDNFEEDLDETPIVFPWAFITNTEKRDAFQNETIKSVCAEFGNAISLIFDSTLLHERTSNNEILKRQTPNHVVKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z566</accession>
    <name>A0A914Z566_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z566"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5393.t1">
        <property type="protein sequence ID" value="PSU_v2.g5393.t1"/>
        <property type="gene ID" value="PSU_v2.g5393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5393.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21335" checksum="6A9165FAB813C76D" modified="2023-02-22" version="1">MQRKACYAEVKRELLNSLGSDSSAATYSLRAHLDKLVKPANKNYRSFLEKVERKVAEAFGSNKNQREQELKKILLRLTQEDPDTSYCSITLPHTAAGYYRLKELVLGIEDANKMRKQNKHLVEHGSPEKSFSHIDSSQCDLAAEHQQQQKQAEVGEHQQRCPALERQALKMLIGYKQLMWPINVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6D7</accession>
    <name>A0A914Z6D7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6D7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8246.t1">
        <property type="protein sequence ID" value="PSU_v2.g8246.t1"/>
        <property type="gene ID" value="PSU_v2.g8246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF5">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8246.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20909" checksum="FA62FF838B0BCC6E" modified="2023-02-22" version="1">MYKFLRTVLLMATQTIGPICTISFLSVATEYKIYTSLQARRKLFESQQRRRSVILLEELKEKVSRAVGIFIAVKFLIFRSLPIFFDIYETIHGIESFGTIMSMLVRISDFAVVLNAATNSLAYFGRRQWLENRLKDRILRKHGVAERSANFDSSLMCQDSVTTNKTIIITKTSPDTPHANFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z738</accession>
    <name>A0A914Z738_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z738"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8508.t1">
        <property type="protein sequence ID" value="PSU_v2.g8508.t1"/>
        <property type="gene ID" value="PSU_v2.g8508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="2">
        <location>
            <begin position="70"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8508.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14363" checksum="531DD7C176E06E1A" modified="2023-02-22" version="1">MKSLQIFVQIIGHVSVKKAPKVIVQSASSPLLTSPRSDLPLFEVPVIENSNDVDKIYDNVVQFCKQYKQPFIDDSFPHSTRSIGDFRSLEKSQIDIIWLRPSEIYTKDGRVCPWKVFNNPKPTDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8C6</accession>
    <name>A0A914Z8C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8C6"/>
    <dbReference type="SMR" id="A0A914Z8C6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6505.t1">
        <property type="protein sequence ID" value="PSU_v2.g6505.t1"/>
        <property type="gene ID" value="PSU_v2.g6505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF4">
        <property type="entry name" value="UMP-CMP KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6505.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25356" checksum="A880C2A6CA69A375" modified="2023-02-22" version="1">MQSITPPLIAVIGSDGSGKSTVCEHLITVVEKYGAAERVHLGKQAGNVGRAVTKLPLMGKSLHKTIERNQVKTAKKLPGPVPALVITAFVARRLLRFRHMLACRRRGLIVLTDRYPQDQIPGAYDGTVFPPNVEGGRFVSWLASQERKAFHWMASHKPDLVIKLNVDLEVACARKPDHKRESLARKIAITPQLTFGGAQLVDIDANQPLEQVLVDAEKAITDFMTARGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8C7</accession>
    <name>A0A914Z8C7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8C7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8152.t1">
        <property type="protein sequence ID" value="PSU_v2.g8152.t1"/>
        <property type="gene ID" value="PSU_v2.g8152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8152.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34719" checksum="C5C1BE58A22EBA93" modified="2023-02-22" version="1">MMNQPRPFSNNPGIPDSPLLHKSWHNPGWPSNLLNVENIIHYFCDQSNPFYDTQSDNQTLIMQGLPMDRLSKMNGIQYSLVHACGPLFVIGKLKRASETNFTPICYYYCMDGTIYQCPDLYTFIQSRLAQTTNPLREALSQASKYSRFDVNKGYTWEFDADASKSAETIEEEKEKKSKKSWYQDPNKVRSSQYQWKRADRILQMTLHRYPPGSGMHIEGPSRMEIDNSGPTSVATTSRQTPMPQQLNSLEPASNITIGPITPLTGGAPTPGGGLLSAPNSHLATGGPGSVSSRIVNSPAMRRNNGTPSKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8G0</accession>
    <name>A0A914Z8G0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8G0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8189.t1">
        <property type="protein sequence ID" value="PSU_v2.g8189.t1"/>
        <property type="gene ID" value="PSU_v2.g8189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8189.t1"/>
        </source>
    </evidence>
    <sequence length="736" mass="81003" checksum="B4663FF7F2B50A04" modified="2023-02-22" version="1">MSSAQSYTTPVESDTELQNVGTANDIKIDDHEALLTPVATPALSSTSVMVDSNETSYNQRKKEPKIAEQHNDKQAIPLALTTLDITDDEDETTDKKSAVAEKLVEDMKNDVQNKPLCVPGVEKTAESSNKENNKFLSPSMIYESYDESTKCMGEIETDDKKAQFTVKQHVPSQKQSSNAKETIDKKSDVEKVVKPPEVLFGEKKVEVLGQNFLEEISEDENHVKTGDLKNIAKTHTTAASSSSSSDEEEKKPKLVPPKVNKSTIKPTPVKKKVVVQKPKPVEELSELKSNNRLLEVGLLDDDDSEDDVDKNVKKPTTTSLSNQAKEKNPSKSTSKQDSCALNHGVLADTSDEDQSDVEEVSESDEDKPPVLPLSGASATLPHICLSGASSSEDETVNKYSSSNKKVKSKSIESVKNVRFLNEKYVKRSGSESEGEQFVSLEPTKSEDSYRIDIDKKLVSIDYEEKNSDDSDDEVLSSDDEGPSSLEVSDDDTQQPQDAGYLEQDLMESLDKQIAKEEEGKKREEKLQELAKKKKEYEKQGPTENGVTRLENYFDNFIIDIEPAKTESPNEAAAVVEKSKSPPEAAQPSKPIEVKKSKSKSPAKEQVVIKVIEGKKEESKPIAKTEIQKPQVESKKEAVKLKEVKVSSIGKYDPSIPIVGEDFIDQISCSEEVVTVKKATPIKTAANKPTSIQPSTVSQTSNAVQRPDPVVEDDFLVEIQASNLAQRPTPTCCCCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAT3</accession>
    <name>A0A914ZAT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAT3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8876.t1">
        <property type="protein sequence ID" value="PSU_v2.g8876.t1"/>
        <property type="gene ID" value="PSU_v2.g8876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8876.t1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41188" checksum="473674F6619F64E3" modified="2023-02-22" version="1">MSVKKASALTPDEEIERDYKIYKDRFEQWKEQNRSAVGTDAYIKYVQQFEAWEKDVEKRRAVAKKKVENDKSATENDDAAAKAYAQQQEQYMRMHQKGMAEDAIRSRFSTGHFKAAAHNSPLAATVNVKPMESEVSSLMSAMQTVIQSAIKSDIRSPADALKPVQAQSATISAPPVMKSQQQLPIPVVQQPPVVKPVQLWWTRQAEYGPHDRLFHSFGPRAAPATTKQVISDSYNYYVPGWLVQKEMAQNLLVFPNSTHRSTLEAHPSKVDPPKQLPSLMSLEVPFPQDFTIPPPNFRPPLPPQNNSSIPPAQPAPQLHVPMFNPNVPPPSINLSMPPPQFLPAGMKRTHSFPGRQLEPMHIPPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBA9</accession>
    <name>A0A914ZBA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9939.t1">
        <property type="protein sequence ID" value="PSU_v2.g9939.t1"/>
        <property type="gene ID" value="PSU_v2.g9939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9939.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9133" checksum="B9DBCBAD39BC17FC" modified="2023-02-22" version="1">MGPRFSRTIVGLLDENKVDYWTFDILEDAEVRQGLKEYSEWPTYPQLYLDGELLGGLDVIKEELKNPSFVEKLPKRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCP4</accession>
    <name>A0A914ZCP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Salt-induced outer membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9700.t1">
        <property type="protein sequence ID" value="PSU_v2.g9700.t1"/>
        <property type="gene ID" value="PSU_v2.g9700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007433">
        <property type="entry name" value="DUF481"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04338">
        <property type="entry name" value="DUF481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9700.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24342" checksum="B8A763ACD5B8F6BD" modified="2023-02-22" version="1">MDDPASAKKPFEGNLNAGYLAQSGNTKSSSLTADTTMTWYGHTTAWSLWGNASNTSSNDERSSEKYAAGGRSRFNLTDYDYLFGQASWLTDRYNGYRERDVLTAGYGRQFLNGPVHSFRFEFGPGVRYDKYTDNASETQPLGYASGAYAWQLTDNAKFTQGVSVFGAEDTTLNSESALNVAINEHFGLKVAYNVTWNSEPPESAPEHTDRRTTLSLGYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDI2</accession>
    <name>A0A914ZDI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9998.t1">
        <property type="protein sequence ID" value="PSU_v2.g9998.t1"/>
        <property type="gene ID" value="PSU_v2.g9998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9998.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17059" checksum="A1292564A49B08AC" modified="2023-02-22" version="1">MLEANSAQLKTMLNQARTIAFEKFECPMCKAIFQSRGECSEHLDLEHPLARVERPMFCEICLKSFVDRKTMEQHESYHKRVHLLVESGELELNDPEILVPSIDDEVSGDIFNEQIQDQMPQLQNHDSLQIPISHDPPQSEDHDEQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFZ9</accession>
    <name>A0A914ZFZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZFZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9209.t1">
        <property type="protein sequence ID" value="PSU_v2.g9209.t1"/>
        <property type="gene ID" value="PSU_v2.g9209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="8">
        <location>
            <begin position="722"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9209.t1"/>
        </source>
    </evidence>
    <sequence length="880" mass="100504" checksum="BBB94BD70779565B" modified="2023-02-22" version="1">MSLDLCIDPLDCEFPGLVNEILSLPTDNNDRSMVLACSLTPEGYAYFLCNKVLYVWNYLTKEKGVNPHAFRLNLPSTGLNYSINSIVVTSKDSTGLPSVLAVSPEGLLRYWPSISASVPKDKELSFNNEVVLSIIPYSDEDHVTRYILATTTGSFYNIDIFKEHFLQGSGADGAITYRSIGINSSSLTRRMTSVIFGGASKKQSLIKTLVVKNFFASNEADLVAVYLNEIEICSVKKANVVKSIDARDYILRSYLKTANEKIPDPKRLPNIYIADVIQYNNGLLMLIAVAKQRATTLSFGLIHLTEESINDNSANFVTLVGISEQYRLPVPQVDQPLPKINLYTPTPTNFIIVFPTMVVSLENVDVGAESLCDITKFKEQLLGSACVNQFCQVILRKNGICDVRHLPSGFEINFWQKYKSQMESIDAESNSHFAMLKKVFMLFASKNLPEARSKFAQMIKSFGDYNELAEFIVLMTKGLLDRIPPTSSVRSISIASQLEDKVAHYKMVTMFLRYFGLFDRLSHSSKTFNGRSALTVLSEYGEKLYAMTITIAMISQLTLPTVESAIKRLAMEIQTQLRMTDNNILTDHDYFAKEVTSFEALIPAAMRIQQEEVKGKSRTEQISLFTEVLSLYNTVIDATQFYKSQEWAIHIKRDEQIWTNSQQVLTHFNRQFNLIFDFIESERGNYESLLKKLLPIARFILSQQSLYQRNRSSIIQRFYRFGKIDVALKLAEEYLDFATIIQHCYEKLPDVERQYQLEKYKTQFKNENFDIFLFEYYREHGLINDLLEQQGDRVEDFLSKHDEINWIRNIERREYSKAKETLRSIAYSAPNAERKKTLLSLAKLAALCEDEQNPEEVAQITNNLILLQHQEQISPDIAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRB9</accession>
    <name>A0A914XRB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XRB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1054.t1">
        <property type="protein sequence ID" value="PSU_v2.g1054.t1"/>
        <property type="gene ID" value="PSU_v2.g1054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="10">
        <location>
            <begin position="139"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="173"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1054.t1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57000" checksum="9213AC39B4D5F0B6" modified="2023-02-22" version="1">MADISSQLNQKYDELRNIGAELATLVGREPKFPRKRAMTTDEEAPPPARRDNDRRISYETNDRKVSHEASDRKVISYEPAGSKRSRLIEDEPVRRSDRHEDPPSRRPTLQSTVRMPTIETKSREEVLAERKSQTKADGARNRRMFGNLLMGTLKQFQKEEKAPDVAPKTQAQHDKLKEVEERLEKSVRQDKEKYLQDKKAVEVKLREKEMEIKRLKQRQAIQAKNESKIVHYKRLQNFIQTETKPPIFFLPARLTLRGMELLKQTSRNMETLIKERQTEMETELRELEELSDGEIGPAIRSLVKVVSHDKDSRAHLKPTNGDGNMDDPMDDEDDDDDDLDDVFKIRSSVVVVKPEVKNLNSEEKSKEEEKVNAEKKESDGGSKEDEESKSKGDKEESRSKSDKNVSKSKNDKEESKSKRDKEESKSKRDKEEAKTNGDKEKSNGDKQQSKRDKADSKSKGDKADSKPKTDKEESKPKGDKEGKKVSSKKHGSASPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSW2</accession>
    <name>A0A914XSW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11056.t1">
        <property type="protein sequence ID" value="PSU_v2.g11056.t1"/>
        <property type="gene ID" value="PSU_v2.g11056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11056.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11644" checksum="B47E3B3B35BF6DAA" modified="2023-02-22" version="1">MIFFLNANPVGDDAKVIIYEVDDHTAMDYVTEDRVRNQRFRLKVTDDFDDWPTPKLELFIEFENCCGYWFTKRVSGFLKNASSVSYTLRDENLIADIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTD9</accession>
    <name>A0A914XTD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTD9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1023.t1">
        <property type="protein sequence ID" value="PSU_v2.g1023.t1"/>
        <property type="gene ID" value="PSU_v2.g1023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.105.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1023.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11556" checksum="E3EC798A1C0833CD" modified="2023-02-22" version="1">MGFVTWGSGSVADASASTSKFFDGSDIDDVKNAELTATLKQADTTTDPEKRKESYSKALRQIADQAYWVPLWTYTTNYVMAKDLNFTPTPDEFVRFYDMSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTI8</accession>
    <name>A0A914XTI8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-tubulin N-acetyltransferase</fullName>
            <shortName evidence="3">Alpha-TAT</shortName>
            <shortName evidence="3">TAT</shortName>
            <ecNumber evidence="3">2.3.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetyltransferase mec-17 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-[alpha-tubulin] + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha-tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15277"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.108"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase ATAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.108" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XTI8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10579.t1">
        <property type="protein sequence ID" value="PSU_v2.g10579.t1"/>
        <property type="gene ID" value="PSU_v2.g10579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10579.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29801" checksum="DD58EC509B24958E" modified="2023-02-22" version="1">MEVSGNLSPILGSSLVRLDAMRLKQLQCDKVYKAIDDICQISADSVHLRKPLTTCEKIIQSDHTLYIAWEYDEEKDVSRFLGILKIGHKKLFLYDRQMITYEGEFLCLLDFYVHSNYQRKGIGQKLFDYMLKNERIQAFQVPLDNPTVTLLAFMNKNYELTDPIWQNTNYVVFPQVFESVKYTEDEAPEGWRKIQPRQIGNSSTQSRWLTHAISGHRVKGHSTGSPVDADTSTEGTLANRAHQARQRKNQLLSSKPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTV7</accession>
    <name>A0A914XTV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nematode receptor-like protein sra family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10404.t1">
        <property type="protein sequence ID" value="PSU_v2.g10404.t1"/>
        <property type="gene ID" value="PSU_v2.g10404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051080">
        <property type="entry name" value="Nematode_rcpt-like_serp_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31357:SF5">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31357">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10404.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26896" checksum="58718885F9660789" modified="2023-02-22" version="1">MSYQTAAEITKYAYHISPSECRSVIIRWKCLLLRIPGFSPIICFSLLHLFIFLERCCATFFLKTYENAPKRYGYAAVALLLTIFGLWVFYIFYDEDLFRYNPYCGATSATSAPRILNTYYIMLALDAGCTIGDFWLLWLSKKRMNLRNAFATSRHLRTMPEYYQLSQSYQLRENKVTTALVFPFVTAHSLVFFTYLILTTTFRLTIGNGTTPVIYTTSVEGAHVVRFSFIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUK8</accession>
    <name>A0A914XUK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10651.t1">
        <property type="protein sequence ID" value="PSU_v2.g10651.t1"/>
        <property type="gene ID" value="PSU_v2.g10651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10651.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35782" checksum="85187F9D964E4185" modified="2023-02-22" version="1">MSSSFADSPPESPTLKFFSYDEFCASYLPQRFSLPESIVFYMAKNPPLTGVHRRMLKSCKYFFIKNPIIHFHCLQYDDKNGWKTCISRSCLYQGKEKYRKINLKLDKIQSKIFVFFALNISSSNPTFAASLIPKMYTNKVHCVEFSRQKMLFDDFLFFSKKAIQCYVRYSNVLYKNGNEVPCEVILANCPKLRYFVHSAPNNCYNAVNVAELLKVPHFKKLIHFSVLEIFESFDIEKFFGYLKKNIRTNVVIGFNAPFSEEYKKRLQAVVDEIIDAGSSRTYRTPCIMFDEQLRQKELIAAFKKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUU5</accession>
    <name>A0A914XUU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1074.t1">
        <property type="protein sequence ID" value="PSU_v2.g1074.t1"/>
        <property type="gene ID" value="PSU_v2.g1074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1074.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19198" checksum="B3C21D0D102CFEC0" modified="2023-02-22" version="1">MHGPVPGYGMIPWGVHPMAPHMHPHHAAAAAAAAGMPPHMHGMPYAMHAMLAATQQGMYVAAAPAMSPYAHAHMYAQQEQEQEEEQEQEQEQEGQQEQEQEEGADLAQSQAPKQQGQAQYPAMALMSGYAPNMAYGPVYGPGFMPMHMAASQAHPYAYAHPHAHAHGPAHSHSQSQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUV1</accession>
    <name>A0A914XUV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11719.t1">
        <property type="protein sequence ID" value="PSU_v2.g11719.t1"/>
        <property type="gene ID" value="PSU_v2.g11719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037103952" evidence="3">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11719.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21252" checksum="7AA0460D07642DBC" modified="2023-02-22" version="1">MLKAMFSFILFILTLTAISLLYNLEIDQKDVSTYVVITVVFLAVVTMIAAICYAINVKLRRRYNSQIPDDHISRIDEPSTGNPTITSRPTLNQDILQMIQRLQQFPDIVLRTLPTYNKAMFNSRPVRVTKKQGNTELPPEYITVTSPPPITAEDPAPPSYPNSLNRGMTRSVSFHPFQPSTSSTSSSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWL6</accession>
    <name>A0A914XWL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11359.t1">
        <property type="protein sequence ID" value="PSU_v2.g11359.t1"/>
        <property type="gene ID" value="PSU_v2.g11359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11359.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8059" checksum="C763FA0047D7FB8A" modified="2023-02-22" version="1">MGLHELRSRLTIIPQDPVLLSGTLRFNLDPFSNFNDSELWSALEEAHLKQFVESKPDGLSYEISEGGENIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWN0</accession>
    <name>A0A914XWN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-bundling protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWN0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10940.t1">
        <property type="protein sequence ID" value="PSU_v2.g10940.t1"/>
        <property type="gene ID" value="PSU_v2.g10940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23338">
        <property type="entry name" value="beta-trefoil_FSCN_FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10940.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29889" checksum="BE64CCA516BAD64A" modified="2023-02-22" version="1">MSDYRNVKTGGLKIKNKPLFKADKKANKKSKTTTVVDQDKVDHGGWRRIVDELDVRGGSDVCIETGDASRRYVAAMDNGKFTLGAPHPKAGDKPNPEEIFAMIKTPDDSKFSMKTGYGKYIGVDANGYLVATADAIGPRERFEAVFQDGLCAVQSVSSGLFLSLKTNDEDLIMVVSKTAKEHEIVNLRTLEDRQEAPDYIPADDRKAAGACEWTYQQMYQHSKVVTKNRMINYDRNDKTSVKQAQQEGNLHEVLLNRRAKQKSDKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWV4</accession>
    <name>A0A914XWV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11017.t1">
        <property type="protein sequence ID" value="PSU_v2.g11017.t1"/>
        <property type="gene ID" value="PSU_v2.g11017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11017.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14399" checksum="77E5AF0C762CC0A0" modified="2023-02-22" version="1">MDVKDFFDAQSEETTRILVDLMEIVKLIDVYNRAVCRACRYMRCINFGMKVDAVQNERDLIGKRPRGMPSSQHMGPPSVMPSMGGVPSSSQIPQSSTGHSSTFTNSSPPISSDPLMDSTWDSPPNLLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZG7</accession>
    <name>A0A914XZG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZG7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12607.t1">
        <property type="protein sequence ID" value="PSU_v2.g12607.t1"/>
        <property type="gene ID" value="PSU_v2.g12607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12607.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9649" checksum="D76F50E89B6001EB" modified="2023-02-22" version="1">MQTQLSALELIAQQYESFSMDSKPDAPVQVEMLEKFLDSCFENFSKTFDDKDYQSVTRSFLQWVETTNLQKPAQDMIDVAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZY4</accession>
    <name>A0A914XZY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13526.t1">
        <property type="protein sequence ID" value="PSU_v2.g13526.t1"/>
        <property type="gene ID" value="PSU_v2.g13526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="164"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13526.t1"/>
        </source>
    </evidence>
    <sequence length="583" mass="66162" checksum="B8F3D81DAEB50A43" modified="2023-02-22" version="1">MNSFHDLNRLQTIKLSGNQLNETTLSSIVACRKLRVLDISYNNFRFFNDRYFIAYKDLKPKLNFYLFSALSQLTFLEELNLSGNLLSSLSTEISQLPSLQVLRAHSNRITNIPDLSFSKSLKIIDLSNNRLLKLKVEYCVGENLKFLDLTCNPFSDETNNLSIKSERRAISIVDISKRSALSNIQFGFSETPGQKTKQSTQQLRPKNLNDITFAIIDGGSNPEITDVVKSTLKHHLETPNREDPEMLRRAVLRTHEDIGKKGNRLGASDDLINGVATSGTAIGYTFLYPAVVPNPRLHCINCTDEDDFIVIANRVVWQSLSEREIIEAVKQCTNPLQAAKRLQDMCQAHEQIGNISIIVIKFASPNKDGTILRNNFSRFPTKEKSTFSPPKYSPISLPIETYQAKPFHLRSFSEQRVTNQSTLKNIENRLKKISVAINRIDSDSSGIYYVNPPNSNENKTNGRSTLRKIKDRHKINETVRLSSSHSESHLTSSSQNGYILNYDKAIHLQQPPQTYISQHLLPDIANVGNFSPPLTSDTATSEDSSVFSQEKFQEARKKVEKQLCLDKPYILPKQNVYVRRHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y054</accession>
    <name>A0A914Y054_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y054"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13587.t1">
        <property type="protein sequence ID" value="PSU_v2.g13587.t1"/>
        <property type="gene ID" value="PSU_v2.g13587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13587.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15498" checksum="A74FDEFEBE258858" modified="2023-02-22" version="1">MDSKKCDEISKENGIPILVKLMNCSKNLLIRKQAAFILIDVIEKRQFCEFHRVKACDRLKIKDDKDGIPDNCKKIVETDAILLLLSKQLKCPKSPDWKLCKRILTLFETVSEEKIRKCKAFFFKLIYFSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1G8</accession>
    <name>A0A914Y1G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1G8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11669.t1">
        <property type="protein sequence ID" value="PSU_v2.g11669.t1"/>
        <property type="gene ID" value="PSU_v2.g11669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11669.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25146" checksum="44D0E0214F4E912D" modified="2023-02-22" version="1">MIKDESEQHDGNEVDNQSNILLMFIERILCDEYPLHLKQYVTVGENPTFGCYQRLQNVNKNLHMYDTLNLSNPNAQLHSMKKLIDRYTASVATTQPKHGKTGTVCKINVMETLYIQFMLYSDAPGDARAFLHLLPKLISFNARLFDVLNSKTFALNTKSEMRNIKCSINAFATFELQRMKKNISLHHETSLQATWQEIRDHSIVLDTKNLMKYKSAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1W3</accession>
    <name>A0A914Y1W3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1W3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13445.t1">
        <property type="protein sequence ID" value="PSU_v2.g13445.t1"/>
        <property type="gene ID" value="PSU_v2.g13445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13445.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11765" checksum="D63A21BD92D8BBA1" modified="2023-02-22" version="1">MDELFESNSKAYVSPEINIGEFCEKALEAQQKLTEYFQIPAQSHFQQLQASSNIPMKIDEAALETDCRLSFKYFLNAKGIGLDEADEVINFMDDSLQELFSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2N5</accession>
    <name>A0A914Y2N5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit RPN11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2N5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14441.t1">
        <property type="protein sequence ID" value="PSU_v2.g14441.t1"/>
        <property type="gene ID" value="PSU_v2.g14441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit RPN11 C-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14441.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9677" checksum="A46C57086E2DF9D0" modified="2023-02-22" version="1">MESLQLENFTTHNQNNEESVSQVLKLSQCYKKSLEDEENMTEEQKAKNVGKQDPKRHLDETVNKMLADNIVQNLASMMDTASFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3C2</accession>
    <name>A0A914Y3C2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3C2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13947.t1">
        <property type="protein sequence ID" value="PSU_v2.g13947.t1"/>
        <property type="gene ID" value="PSU_v2.g13947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="7">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13947.t1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44906" checksum="83F09FE55767CC68" modified="2023-02-22" version="1">MVNEHGIIITQSAGNDGPFISSCKRHAVFDANEEIFSIGSIITSDINNYVDDEYSNYVDPPDVWSYSSKGPLPTGARGVTFTAPGDAFIENPKWHPVKQILCSGTSGATPNAAGAIACLISALKANSIKYSPQSIKLALSNTAYLPNEENRLGFGNGIIQINSAFEYFKTHKQMLENIESPPQLTIKNSDMKGIILHQFSNTADSNNYCIKVKQQKQIPWILKLKPENQKHVEFSKTVSKNSFNVKILSKNLKPGKYYYSEIQGFDPSNLSLGPIFHFPITVIVPEKVSNNSFKKEILVKPCTFLNFLINPNESCTKCTVKFIDSENEKNEFKKIIKKSNKNGGTYTESYIKDGQNAHRWFIDIRWKEAFELYIYQKFLYHKQLELKGILEINFKTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3G1</accession>
    <name>A0A914Y3G1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y3G1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13772.t1">
        <property type="protein sequence ID" value="PSU_v2.g13772.t1"/>
        <property type="gene ID" value="PSU_v2.g13772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="14">
        <location>
            <begin position="45"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="13">
        <location>
            <begin position="303"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13772.t1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47429" checksum="55D7B5E9592BBBDD" modified="2023-02-22" version="1">MAEFLELLAGNKVAVFKQPLHSKIVAETLAAGMKNSTEPFVLVSLKKIVEKFQEWQRELPGVMPYYAVKCNDNIVLLKTLGSLGVGFDCATKAEIDMIINEDIATADKIVYAHPIKTPEYLKHAHKLGIPRCTFDSVEELYKMKALAPNMEGILRISCGDKTAERKLKYKFGCDPVNGAPKLLRQAKEIGVSVVGVSVHVGSRCCDPRAYERAIAYMKDIFDDGISMGHPMTVVDLGGGFPGINNEKISLAAIGKCIIAALNKYFPESEKYEFIAEPGRYFATTPFTAAAKIFGRIKVSANRITEKEEDANKDGYMYFINDGVYMTFSCKHFDGIHPLSQPLTSDDGTLPRVPATVWGPTCDSADIVEAVTYHRKLNIGEWLYWEDVGAYSTATAVEFNGFPKAKFYYYADQETMKMIKSGDNKIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3J7</accession>
    <name>A0A914Y3J7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3J7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1402.t1">
        <property type="protein sequence ID" value="PSU_v2.g1402.t1"/>
        <property type="gene ID" value="PSU_v2.g1402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1402.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21654" checksum="0C1EDC57C4657E2A" modified="2023-02-22" version="1">MRLNIVQSGLSMFGVMALIFTVIKCEDIFTELDRIDYVWPTAGVHGNANVTDIECYREIKSNGIGKIFKLHLGLTDKTKYRCIIKLPTPVDIQFMELNFADKRTFTRLLSGNTRSRPVLGSQPLYNDNPRDDYGEFTVQCLHGYIVVGNSQPNDSLTFLIKELDEDAPVVTEESCTKSYIHTRGERTLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4F2</accession>
    <name>A0A914Y4F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4F2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15078.t1">
        <property type="protein sequence ID" value="PSU_v2.g15078.t1"/>
        <property type="gene ID" value="PSU_v2.g15078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15078.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9096" checksum="DCF079658FDF057B" modified="2023-02-22" version="1">MQYSQMPQDGSFRPMQVAYGKRRRPTRCCRYVSPSKIDKCSRYMFPVLFISFNVGYWCIMKFLSSLTANQNFVRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4H6</accession>
    <name>A0A914Y4H6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4H6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13675.t1">
        <property type="protein sequence ID" value="PSU_v2.g13675.t1"/>
        <property type="gene ID" value="PSU_v2.g13675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13675.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="28330" checksum="48CA5F64BC7FD13B" modified="2023-02-22" version="1">MDEDLDGLPEDAISLESSSSDEETATSTKQEKPRQRSFNSPKLSFSDEGSDDEDEAMEHDGYEKKERHEPAEHDGRNRKEERSEVIENGGHERREKEERHEAMEHDRKRKEERHEGMEQRYDRRGKEERHESMDHDRKGKEEKQWIRIRSDRERYGARGIGEVWGRSPTETDLIEIYKKHEKAEKVQKHERRKMEEEEKERRKDRDKAEKRKVQKEKLGIADASGSESAASSSDKIKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4N3</accession>
    <name>A0A914Y4N3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y4N3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1440.t1">
        <property type="protein sequence ID" value="PSU_v2.g1440.t1"/>
        <property type="gene ID" value="PSU_v2.g1440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000060">
        <property type="entry name" value="Probable beta-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037250079" description="beta-mannosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="12">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1440.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23573" checksum="F1CA9DF06F67DD75" modified="2023-02-22" version="1">MWFWVFCFLAILNAQSCFGIEQKISLNSEKNNQTWSFYATKNTSLKGYGNVPGDIYTDLWRSNIINDPLKDSNDVAYAWVGKTDWSYSRMFDLPSDALQASQIRLNFAGLDTIAAVYINNIFVLNSKNQFIDCSVDLKGRIKPAGNILRIDFTSPVTYAQKQSDAYKARYGHIVPPDFPMNIQNGEPHPQFLRKSQASFSWDWGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y599</accession>
    <name>A0A914Y599_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y599"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13948.t1">
        <property type="protein sequence ID" value="PSU_v2.g13948.t1"/>
        <property type="gene ID" value="PSU_v2.g13948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13948.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11808" checksum="4A8D6BB3561496AE" modified="2023-02-22" version="1">MGSFASLFANEPAHPVTNFANYILSNTTLSGEAGTSSQVSQSQPSSSSSSSSSSNTRSNLRPKAKYHLIKYLTILPTIYEENDEFPDTSEDEEEEDDSCGSPHDTHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y656</accession>
    <name>A0A914Y656_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y656"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14923.t1">
        <property type="protein sequence ID" value="PSU_v2.g14923.t1"/>
        <property type="gene ID" value="PSU_v2.g14923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498:SF1">
        <property type="entry name" value="COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14923.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27579" checksum="B9F3A5518D6F0DDE" modified="2023-02-22" version="1">MENGALFSAKIFIDATYEGDLMAFSNISNVIGREAMTKYNESRAGIRPGISYASVIMCDTSDNGNSAYFSNGTLLPFVTSKTPGDLGYGDSKTQAYNFRISITNDSTNQVPFPKPPNYDPSIYTSVLRSSLRTIKQLGAIEAAQKYFPPWQYIFNNKYDLNNYDTDFIGANWEYPRGNYSLRAKIWEDHVNYDKGLLYFLANDPGLPAEYKAVINKWGLSKDEFADNQNWPYALYVREARRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y675</accession>
    <name>A0A914Y675_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y675"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15698.t1">
        <property type="protein sequence ID" value="PSU_v2.g15698.t1"/>
        <property type="gene ID" value="PSU_v2.g15698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15698.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33136" checksum="C9472C71FDCCF67F" modified="2023-02-22" version="1">MLLLLCERSFTTLYLVTHGFRSVVTFTLHFIVFSLTILRLRHNPITIYPKAVNSISTLQELDLSYSIINILNQTMMGKNEHLSSLIIHSSEISKIEDCTFCEFSNLTKLHLYKNPKLSFIDENAFGYAKNETVSKLKSFSLEYCNFTVIPEKLLNWHNVGEFGIVGNPFNCTCEMSWLIDDILNPYHTMNLGRIADSYPEETLVCKTPQKYGNLAFYKINKNYCKSEKHENGQSSETSFFIGFLIVAGLIFFVFAVPLCRYLLRLRKQKTLFNYAENKVNEDFDNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6R0</accession>
    <name>A0A914Y6R0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6R0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14950.t1">
        <property type="protein sequence ID" value="PSU_v2.g14950.t1"/>
        <property type="gene ID" value="PSU_v2.g14950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14950.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26590" checksum="B5898545CA779544" modified="2023-02-22" version="1">MKLYVHLLDEMLQEVLDRYHENRGGFPSSIVIYRTGVEEGLYPSVLRYEVPLIEDCISKKAPNVPFTLIAANKQHNFRMTPEYIDPRARAVDQNVRPGTIIDTHAVHPVFNQFYLVSHLAIQGTAKPVKYTVLQSTEDEKDLSMDKLERLTNDLTHKYQIVKSPVSFPAPVRVADDYAKRGRQIYKILYRPPSEHSGSPGPEEAEAANVYLAESQRYNFAHRPLLRNKRTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6U3</accession>
    <name>A0A914Y6U3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6U3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1593.t1">
        <property type="protein sequence ID" value="PSU_v2.g1593.t1"/>
        <property type="gene ID" value="PSU_v2.g1593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.930">
        <property type="entry name" value="Mammalian shaker kv1.2 potassium channel- beta subunit complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF234">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1593.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17065" checksum="5F5986199B0D943E" modified="2023-02-22" version="1">MRLFKLTQHSQGLKILLHTFKASAKELMLLVFFLVLGIVLFASLVYYAERVEVNPDNQFQSIPLGLWWAVVTMTTIGYGDMTPHTYLGRLIGSICALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKKRAVLNLEQVREKCMPLPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y730</accession>
    <name>A0A914Y730_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y730"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16015.t1">
        <property type="protein sequence ID" value="PSU_v2.g16015.t1"/>
        <property type="gene ID" value="PSU_v2.g16015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036779388" evidence="3">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16015.t1"/>
        </source>
    </evidence>
    <sequence length="433" mass="47522" checksum="1656A31E801C4CC4" modified="2023-02-22" version="1">MAQTYLFITFLAALLYLCHGDNTENITTADTIKYYYKQNENENQKWHFNFASDLRGFIIFNQNFELNKGETVLVYQKDGSLAKYFLANYTSTSTKLNSTNFQRLTAEKGEGLTVVYNFVSPTPTTPTTTIQTSTVSQSSTSTASTTSLASTSTAPTTSLASTVTGPTTMPPIFMFLVSSYNETASLMNNTQDSGIWDTTNVTNTIVQTIQTHGNVTQIWHYYPASQDRRLSFALIDSTALKNNVGATLTLYRGDANDLSNTSTIIHTFNDTNSLDNIYTYGGKSYMYGGNYGEPLSLYYDYPYVNETFDDLREYGFNFMVGVLLLNESDPAPPVTDVNGNTVTTLPPITDANGSTKPPVPTVIVTDTNGNTVTDSSKHAVTETLPMTVPTIPTVSTTPTIPMTTTSTASSMSSFFFVSLAPIIITFMFHMCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7X5</accession>
    <name>A0A914Y7X5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7X5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13702.t1">
        <property type="protein sequence ID" value="PSU_v2.g13702.t1"/>
        <property type="gene ID" value="PSU_v2.g13702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13702.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49108" checksum="5BEE7BFC7FD5149A" modified="2023-02-22" version="1">MSSAVSNNIPNPLSHKHDGSPHSLSTLSSSPACGSNFSPNQANFSQPNCGVVAASTTSTNSNGNGYQLYGVSPTEGSTASGICSNNNGPMSNVENSLTGNIDNNSVKMKDDFYFSDDMQMTTNISNHDPTFSSALPSTPSGAVKEQLLEEEDEDDSRYCLPPQQHMLQQLQPPMQMQIPPFDQITQARKPLYPINPITDRNFAGRLPYAYNRPSIPYPYPIPAGMSPAEALNRSQAYPPMMQMHYAMMHHPRFMHPQMLPPGVFPPGMMPPHGMMQGMPPIPHPNPPAPPPPQPKPKSRSRKQNNNNNQQQQQQQQQQQLPPPMSMMPPSHLMRPPMDMMRASSSTMGPPDMAMNQNIKINGSMKPPVKRYPGLKVAHNGVCPVCTGQITQSDPGVICTALSQGCLAPFHPRCQRISNEALATICTHEHIEWVCTGCSTKQLIWHANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9V7</accession>
    <name>A0A914Y9V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nanos-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nanos family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9V7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15546.t1">
        <property type="protein sequence ID" value="PSU_v2.g15546.t1"/>
        <property type="gene ID" value="PSU_v2.g15546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="3">
        <location>
            <begin position="567"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15546.t1"/>
        </source>
    </evidence>
    <sequence length="687" mass="76856" checksum="B0F98BBD73B3FC18" modified="2023-02-22" version="1">MHTQNQLPNAGLRQVHFNGLPRQPYIPGAQGVVYAQPRGQNPAYFHQAPPHYTQLPQGNPGSSINDSSTTSPPSAASTPGLAPIPTNNGNPLQPGPPVYYSLPHQQPQQPPQRFIPPPPQQYVYVQIPPPPQQGGPRGRPQFNQRPQAIMQYQTLPPNFNMNQRFPVPFNPQSVMAPNEAQFFDPSMQQSQQQNYQKNGYQGKNRRTAQNSNQTSRRGSRHDGRPDSSNRPSSQPSPDPILPQFAEQNVPMQQGQIMQQNPMYAFPPSLLQQGQQYYLQQQYPQEAQMSQPVYVLQGDPSGYHQPNQYYQNVYQMVLPQHQMQQQQQLHMDPQQQQQHFVPPPQSNNEEIDVGAMVQAIEQLKLQEKEHHQSSPEKIESAAVPALDAVSVQGDADDYTPAGTPQSLNPLDAQQMDKLLDEISVDNEKPTEEKASEKENNRAQEAQRKRYQKPEQQHYQPPQRGRGNAQKTTPWRNTSNQQPAQLTKISEEKPKATYPTAPLVFEPSKPTSLPSDTPTPRASPTPPPKVKEVLADVPMIGGVPLVPMIGGKPLVASSIIMKSESSNEHCAFCEQEGKPRHEITSHSTLSKNGIPACPALREEGCKLCGAKGDSAHMERFCKKTTNKENNEFKSMANYIMNMSPNEKSAILIKNMENHPTVQEIESHPDEEFQKGIDNGRRNKTRSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB73</accession>
    <name>A0A914YB73_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g14734.t1"/>
        <property type="gene ID" value="PSU_v2.g14734"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="1"/>
            <end position="99"/>
        </location>
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        <location>
            <begin position="113"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14734.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24482" checksum="2F1116DD7E0EC400" modified="2023-02-22" version="1">MPRHSPPHEVGNSKNYDSKAPRKSYRQYNHGYRPLNTSKFFIPYGATSSSPHHRQNLRHQRSSNFSTRQLNDNNFRRSNLYIPPYNPKPKQQQQQRQKHFNGNCNNSVIREKASDEKRSSNQSHHQHRTSSRLEENQAPGPLLGPQQPHFASAAAPSSTAKNSTIAKIQKSPRKNSTKKFIREYSKIDKKVCVGVLVKTLYSAPQRSNYVSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBC6</accession>
    <name>A0A914YBC6_9BILA</name>
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        <submittedName>
            <fullName evidence="4">SUZ domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Panagrolaimidae</taxon>
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            </authorList>
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        <location>
            <begin position="38"/>
            <end position="283"/>
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        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
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        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="253"/>
        </location>
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        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12752"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1751.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34769" checksum="4D80D94F957ED4DB" modified="2023-02-22" version="1">MSESEKCDKKIEEVADDWENAGDDAIIASVAERQKQLEQNESNLAAEQEQLKIHQKAGGNQTEKSRPEVGDGPIRLLRRQHKGEHQNKTEAELEAEAQERATKALEDREALYQQTRERIFGGEQPASQQSEAVTSESLQAQLQIHLQQREQQRQQQQQLQLATGQRDHLSDVQMKRADTRKTSGQQQQRQPPLSLPLQQQPQPPPLNSLPMMMPPTSVPPPPWFFNGAAPPPPPPQSIYNGPPPSLYGAPIPPSHQQQQPIYGGPGFPGGGMPPLPPPPSAAAAAHFHQYYQYLQQQQQLQGNPRNRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBY8</accession>
    <name>A0A914YBY8_9BILA</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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        </lineage>
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                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g16943.t1"/>
        <property type="gene ID" value="PSU_v2.g16943"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16943.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10057" checksum="BE760C209EE965E0" modified="2023-02-22" version="1">MRCALQSYNDRGNYIACFRYKMLNKHKFLNGVDGEAVEDWGFHKVFRHVSAAEVMEEVPIIEGEAPAVDEEEAGRFKVRCNLMTQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCA9</accession>
    <name>A0A914YCA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17860.t1">
        <property type="protein sequence ID" value="PSU_v2.g17860.t1"/>
        <property type="gene ID" value="PSU_v2.g17860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17860.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21560" checksum="DAA19685E99A220A" modified="2023-02-22" version="1">MLYYTSVNAKTHIPACPDLVSLPNDINNLNTDQLSKLKCFCSGGDEENLGMNVNCIFGSKLEDLMEALNAIDDVNGTIFRISLDHIEIIEGEDGITLEEALSSGSLIDLKEFEIKECRGGALVEHRENQIVEFPHFPKLESIIIENCDLETIPTIFLSKTPILRYLSLMGNKINEIKRDDLTDISNTVCSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCB0</accession>
    <name>A0A914YCB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17063.t1">
        <property type="protein sequence ID" value="PSU_v2.g17063.t1"/>
        <property type="gene ID" value="PSU_v2.g17063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17063.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15530" checksum="FBCB266A4FE2E78D" modified="2023-02-22" version="1">MFLYRFLLTPQPLSTYIKSYAVAVSAAVSISASLTYLIKRSEGLSATRKLIIQRFVPLPATSLASTLNVLCMRAPELDTGIDVFDENGVKIGTSKVAAKQAIIDTALTRAFLPVPLLLAPPCIMPFLEKFEYIFVFKNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCB6</accession>
    <name>A0A914YCB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCB6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15112.t1">
        <property type="protein sequence ID" value="PSU_v2.g15112.t1"/>
        <property type="gene ID" value="PSU_v2.g15112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15112.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33872" checksum="7D8EE582CD0B83CD" modified="2023-02-22" version="1">MVGVPFDLVSLWRESKAPAIIGYCESTSTAISWFTFSSILIIMALTAERLVAICYPFSLKSWFTKKTVIYVIIAIWVLSFFPSVYIGLQFKQVATDFCGKIHLVELGYGSCDFVGWNFAYTFEVMLLLTFVLPIAFILYCYVRILKTLNLMTSTQTVHHPVANQTSDSSATTPTIKQNFLQIHQRQCGPAMSEKAQKVVIKMLVTISVVFFICYLPYHVERLIVWYSNESCEQSIICLLLYPITGLLQYISATLNPIIYNLMSYRFRTAFRLLLKRLFLPTRTKGGTTDHATIPLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCY2</accession>
    <name>A0A914YCY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCY2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16601.t1">
        <property type="protein sequence ID" value="PSU_v2.g16601.t1"/>
        <property type="gene ID" value="PSU_v2.g16601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16601.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11456" checksum="A0843DEFDCC84E5C" modified="2023-02-22" version="1">MWITARSLYHQLSRVLTELDNEPLSEELVKNLRDNIQHIKNPLTNKPKNASQRALCEPGKTVVLSNGQKFSPDRVISDEAKILSDLFDINEVDAVGLILTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD26</accession>
    <name>A0A914YD26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1720.t1">
        <property type="protein sequence ID" value="PSU_v2.g1720.t1"/>
        <property type="gene ID" value="PSU_v2.g1720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1720.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12050" checksum="FAAC3FB1637EB750" modified="2023-02-22" version="1">MLECGHKCALFCHGYDMEHFNIKCEQPCLKICCHKIPCKKLCHEECDPCEFNEDGNCYYKPLENVDSTESILNEEVKVAQEEYSRNAEISFLLDGERPKFHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDC7</accession>
    <name>A0A914YDC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15452.t1">
        <property type="protein sequence ID" value="PSU_v2.g15452.t1"/>
        <property type="gene ID" value="PSU_v2.g15452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15452.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="26382" checksum="6057809177837181" modified="2023-02-22" version="1">MLSSLKHFKPQIFSTGTKLFNRNVHHYLKEQVLPTLEYKPLSRTGDFVLDQRRDRHVIEDGYTPKGAEFKLRFELVDENDYEIMLQIVTENFVKDSNIMRHLKIKGEELIEMMAPMVEKWIQAKNSVIIKDGDKVVGNIFGNIHNRDEFDKLYRGQLFHEKPEFIIKSDYAEDIRNAPFKSLNVNRVAVLLEEMEWQTGKFLPKDTEKLGVHELYVIHPKYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDE8</accession>
    <name>A0A914YDE8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDE8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16775.t1">
        <property type="protein sequence ID" value="PSU_v2.g16775.t1"/>
        <property type="gene ID" value="PSU_v2.g16775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_uL1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_uL1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16775.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="24003" checksum="D58B4FD614627836" modified="2023-02-22" version="1">MAKVSKRAAAIAAKIDRNKFYPVAEALALVKDTATAKFDESIDIAVQLGIDPRKSDQLVRGSVVLPAGTGKTVRVAVFAQGEKADAAREAGADIVGLDDLAEQIKAGQMDFDVVIASPDTMRVVGTLGQVLGPRGLMPNPKVGTVTPDVATAVKNAKAGQVQYRTDKAGIIHSTIGRASFNVEQLQTNLVALVDALNKARPAAAKGVYLRKVAVSSTMGGGARVEIASLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDH3</accession>
    <name>A0A914YDH3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YDH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18275.t1">
        <property type="protein sequence ID" value="PSU_v2.g18275.t1"/>
        <property type="gene ID" value="PSU_v2.g18275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF57">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18275.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28996" checksum="24CACF93D255BA9C" modified="2023-02-22" version="1">MMSRIAQCFTQARECGILLERKEYSETFDFTGGCDSNGKVYTFSDGCGIISPDYCRKIVEDLKLGDCLPSCYQIRFRGYKGIVTVNKLFEIVKEWAERNGKINGPGKDGTLPWYQQSIIFRESQNKFQAPPSKHLEIVKISSPISVSMNKPMINILDQVSEMHGQDAHKRMCNRIYDLLEEHVDSAISSLYEETAASLTLNEFPKYIPYHRLKDFYLTEEPFLRSLLRASALVSLRKNLFFFNKIVYIYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDN6</accession>
    <name>A0A914YDN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDN6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16867.t1">
        <property type="protein sequence ID" value="PSU_v2.g16867.t1"/>
        <property type="gene ID" value="PSU_v2.g16867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF104">
        <property type="entry name" value="PROTEIN SPRINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16867.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22614" checksum="B5E4D4894D5B4E55" modified="2023-02-22" version="1">MESIKQCLRRMQNHYSPLKKLENLLRALTIVILPNRNFNNNNIEYSSKKCNLIQNGTLSGVLGSKKLPPAEELIRWLVYILARTSTINCEIEARYMWDLLPQQLLTTGDAAYYLTTLFSAVHVLKNPESIRRLGKGFPLSSDRYPDNSYDAFLSVAIPDEQSGSIEYHTFPAVPEMNAAKLCRVIAHQFAITNCEDYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE82</accession>
    <name>A0A914YE82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18562.t1">
        <property type="protein sequence ID" value="PSU_v2.g18562.t1"/>
        <property type="gene ID" value="PSU_v2.g18562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036952434" evidence="1">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18562.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12012" checksum="8904BFECC26BC8F5" modified="2023-02-22" version="1">MYFTLFYLLIFFPFTSSTIIGKCNTDTLPPSWLSTAGHGINDWGTAGINLGGNNFCLVGNKSAEIVEVSYHINITQASNFETEILTTLDSGNLTNACLNQDPRIHYCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF44</accession>
    <name>A0A914YF44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF44"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17936.t1">
        <property type="protein sequence ID" value="PSU_v2.g17936.t1"/>
        <property type="gene ID" value="PSU_v2.g17936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF16">
        <property type="entry name" value="HELICASE WITH ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="39"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17936.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26366" checksum="3BFE3DA01758C6AD" modified="2023-02-22" version="1">MVGDVKQLDTFKGSLPEVCIPLGFGSALLHASRATGEGVAQVYLTKTFRFHPEIAKFLSELCYEGKLETTITEDQRPYMSQLSNRELPIVLANVLGKCEPAFPTSRTNKTHTKAAVWLANEAKKKLPECTIVILTFYNGQRDEIMEALGETSIEVTSIDAFQGKEADIIILVTTSTDKFAKTFIDDQQRLTVAFSRARSGMFVIGYAEALRQLPNWGKFIQKLKDKNNIVNLVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFK1</accession>
    <name>A0A914YFK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFK1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16141.t1">
        <property type="protein sequence ID" value="PSU_v2.g16141.t1"/>
        <property type="gene ID" value="PSU_v2.g16141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="238"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16141.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42645" checksum="36CB956C543C04AF" modified="2023-02-22" version="1">MLLKTPLLKACIISFTEKTIINFDEKNEFSLLPQITGSDTYIFHVQDIKGDFEITKIYSQGSGDIVYDYANKTFVAGNYYASYDVEFYITTDIEFKKVAYVNVSHEIEVSAARMKLLKVYECYEEFFALPGHEYMKFKYLIKKIRENYVEIVVENPLEVEIEGKTCDFKHEAADSADIKLALSFVFDPDVLKQSHQHLKIPDASQSLSDLTVADDHEYVQNKSNKPTLYEIMSDSKYADVVLISSDGKKIPSHRCVLSKYSEIFATIFAESKDIPTKINIDGFDANVIVAALDFCYGKDNSIVGYESKLFEFANKYSMHTLKYEEFLTDLRRLPFGRDMRVRLFKNVSLEKLGAVESADGLRARGHGFESFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFP8</accession>
    <name>A0A914YFP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFP8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18140.t1">
        <property type="protein sequence ID" value="PSU_v2.g18140.t1"/>
        <property type="gene ID" value="PSU_v2.g18140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18140.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12531" checksum="E5907B8BA4A65BD6" modified="2023-02-22" version="1">MEGIFPIRVSTEQINVFRKLILYELLSEIDQKDVFEDMHEPKEIFVDEPKDFEDVCDGLYETPVWNSKSETTKFEWITDAVIDKTAELQAEYFGPNAEIQASFLSKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGN4</accession>
    <name>A0A914YGN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGN4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18486.t1">
        <property type="protein sequence ID" value="PSU_v2.g18486.t1"/>
        <property type="gene ID" value="PSU_v2.g18486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="117"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18486.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29823" checksum="D2C39C760E5EFDB2" modified="2023-02-22" version="1">MPTSTTSPSTISLSIPDIEVQTSFPQIRRTNFDRKNLKKAQSVVPLNLNPTTSEDISNPSSTAILPNIDETSPKVENPIISDECVYNSNHRKSLLADILSSYDKTVVPSNESVIITNSFVADVWFSQVWNDPRLDYSNVSCKTNLSLDSSVADKLWTPNVCFVNSKATEVHKSPASNVLLIIYPNGTTWLNYRVRVSGPCVFKLSNFPVDSQECTLVFESYSYNIAEVRLVWQQWQPVTLPPADDFRLPDFEYHNLTWEHTTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI44</accession>
    <name>A0A914YI44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI44"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1899.t1">
        <property type="protein sequence ID" value="PSU_v2.g1899.t1"/>
        <property type="gene ID" value="PSU_v2.g1899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1899.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36223" checksum="304D3682594BE061" modified="2023-02-22" version="1">MSRYENQKGNECLNEIRKFAFYTENGPGGYEITSLSGTKIYDNSRSNNEEDTRTELFDKEFPFRSYHIAFPSTSDIVIEMEVNANKTKECFLDNEFQLSCLCYADNSESKSYKAWEGEKAFYYCGKQQSMICFDYLRGPAVMSSNPTILQNRKDFLKETKFFKNVSSTLITDIKGNDLPIKITFTIYKNATNQIYFTASNRESGSFEIEPFKEIEGFNDYDSMKLKIISVLPFQIFDPNCEIKWKFINGKLLDYANPNIQFPTSVDTKGEFISDKRTIFKRSKEDTINAATKTTNTIMTFIGLLLFYALIMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIV7</accession>
    <name>A0A914YIV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase subunit 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19239.t1">
        <property type="protein sequence ID" value="PSU_v2.g19239.t1"/>
        <property type="gene ID" value="PSU_v2.g19239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19239.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9075" checksum="2B627307F891CF19" modified="2023-02-22" version="1">MSENASCCFLNIKKCAKVVSIAGMIISLIIFGFCLSENKINWLLLGISFIFLISYVFVFIGALNEMASFMLPALIVLGYKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ13</accession>
    <name>A0A914YJ13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJ13"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18821.t1">
        <property type="protein sequence ID" value="PSU_v2.g18821.t1"/>
        <property type="gene ID" value="PSU_v2.g18821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029602">
        <property type="entry name" value="IFT74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18821.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15761" checksum="06175A4EE9D74776" modified="2023-02-22" version="1">MDKTYFMGLLNTQFADLNQEIESLEKELIKFESEQQKLLFYEQRAEEQAEEIKKLQGELSDYNLLIDYQNTNKDFSELQFEVQEEQTKNAEISKQVEDLFRERREKEDASKTLEAQVHEIRISNENLINSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ67</accession>
    <name>A0A914YJ67_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YJ67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19551.t1">
        <property type="protein sequence ID" value="PSU_v2.g19551.t1"/>
        <property type="gene ID" value="PSU_v2.g19551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="190"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19551.t1"/>
        </source>
    </evidence>
    <sequence length="578" mass="67045" checksum="6F5EEC4BAB05BA10" modified="2023-02-22" version="1">MEPSQLNVLIERDGYLAPQIPEIKRRYKVFRESLQKLQDLPGGVDQFTLSYREYGVHLNADNSITCLEWCPGVQGLSLVGDFNNWDPNSHAYKSLEFGKWRLEIPPNEDGSPLLKNGIVYKIAVKKNDQIFYKLSPWTTYVEKAKTNIYEMVFYHPQQPYQWRNSLPHNNGSLRIYEAHVGISSPEGKVNTYRAFADDLIPRIKKQGYNCIQLMAVMEHAYYGSFGYQITSFFAPSSRFGKPDDLKYLIDEAHGAGLIVLLDVVHSHASKNVEDGLNKWTCDDGGYFHSNARGYHSQWDSRLFDYTNLETQRFLLSNLRYWQEEYKFDGFRFDGVTSMLYHSHGLGDCFGSYDDYFGLNTDTDSVIYLTLANYLIQKYHPGSVTIAEEFSGMPALCRPIEEGGQGFDYRLAMSLPDMWIKILKHQQDEDWNIADIVTTLENRRYMEKNVAYAESHDQALVGDKSLAFWLMDKEMYDFMSVDAPFTPVIERGIALHNIIRLLTYGLGGEAWLNFIGNEFGHPEWLDFPRVGNNESFHYCRRQFNLADDPNLRYKFMNLFDQAMNEMEEKHQFLSRGPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJG3</accession>
    <name>A0A914YJG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19655.t1">
        <property type="protein sequence ID" value="PSU_v2.g19655.t1"/>
        <property type="gene ID" value="PSU_v2.g19655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19655.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10660" checksum="D475BADC4A69FA29" modified="2023-02-22" version="1">MSMPSTTISSSLLLPTDPTIALTDLATNLTSNILNSIVENVTTTSDYYSEYDSLPSLPPNGMTEEEFFASLPVFDMFPLSFPTNSHVVLYAMVRNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJS3</accession>
    <name>A0A914YJS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19778.t1">
        <property type="protein sequence ID" value="PSU_v2.g19778.t1"/>
        <property type="gene ID" value="PSU_v2.g19778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19778.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25458" checksum="37EAD914CFD581F2" modified="2023-02-22" version="1">MATALIIGATGLVGKSILANAEKSSFFNQIYTIGRRENPNVSEKVKCLIEKDTDNWPTLITNEASEASESKIFFSGFGSTRASAGSAENFVKIDYGVNYECAKAAKDAGVETFVLISSGSANENSLLLYLQTKGRLEKDIIDLKFQRTIILQPGALIGERDTPRFFEGIMQKVMKCVIDTPLSFLGYPIRGEDVGRIAVEVAEKQPSNVAANEPIVEIITAKELTEMAKKLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK42</accession>
    <name>A0A914YK42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YK42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g199.t1">
        <property type="protein sequence ID" value="PSU_v2.g199.t1"/>
        <property type="gene ID" value="PSU_v2.g199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000007">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF104">
        <property type="entry name" value="SERINE PROTEASE PCP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037893610" evidence="8">
        <location>
            <begin position="21"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g199.t1"/>
        </source>
    </evidence>
    <sequence length="643" mass="70002" checksum="2A6AF9FD1E89CE5E" modified="2023-02-22" version="1">MDLKSIVILFACLFSATVIGSRFFDPVKYAGMNEADFLYEDNADMSTPIYPYKTAWTDVIFPVDHFSYTNADRFKLKYLYDDSTYKPGAPIFFYAGNEGSIEGFANNTGIVWDLAKTFNAMVVFAEHRFYGATQPYGNSTISYSTISKLGYLTSAQALADYAMFLPWFKQKWNLAQNTPVVVFGGSYGGMLATWFRLRYPALTVGAWASSAPVTYFHNAGVPVGAFDEVVKNTFTTSGCNLQQLNRAFQAMTEMGKTDAGRQSLTNIFKINSKTPLKTESDVAALKLYLQGGMEYMAMTDYPYPTSFLNPMPAWPVKTGCNNFGASVQSNTDDISYLQGLLSLTNVYFNSSGQAPTICLNSALCGGDVNGGLDSGNPDGWDFQECTEIIIEMCSLGWPNDFFDSDCNNDTFLQFQYNLCTNIYGSIGWTPSFLREDAVKQEYGWDFSKATNILFTNGALDPWSAGGVNAGTPGIGGSNGDPSRGIYNYKVDGSAHHLDLRQPASCDPSSVISVRFQAVQIITCWINSSAPNCPFQPYALPAFSNMDPNTNCSYLPLGGYPWGQVLPTPTTTSTVSTSTNPSSKNIPQSSTTQPSSTPTGTPATPTANPSSTNTPQSSTQSSAATLKFTVRSVILLLFSFVASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL30</accession>
    <name>A0A914YL30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1959.t1">
        <property type="protein sequence ID" value="PSU_v2.g1959.t1"/>
        <property type="gene ID" value="PSU_v2.g1959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053322">
        <property type="entry name" value="PLA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34228">
        <property type="entry name" value="PROTEIN CBG09474-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038008160" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1959.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12263" checksum="0280BEF56AF59466" modified="2023-02-22" version="1">MNLLFIFCAIFVVPTILAQFPPPAKFECGRNEAENAFAALSVTLNCQPRLAHFNNCCIAHDKCYDNQLGRIECDNAFCNCLQMAAVGQLFCKTLNSRICTCNSILCFEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLI6</accession>
    <name>A0A914YLI6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YLI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20223.t1">
        <property type="protein sequence ID" value="PSU_v2.g20223.t1"/>
        <property type="gene ID" value="PSU_v2.g20223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF11">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="6">
        <location>
            <begin position="95"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20223.t1"/>
        </source>
    </evidence>
    <sequence length="401" mass="47195" checksum="304D2E8A91D02ED6" modified="2023-02-22" version="1">MDIKVGKILLRTFRRYLGIGYGNPKSWSRKLFYISILFVTFVLFTLITVNYETKTDQKFVRRLYESTIPPQLKQQPLQQPYHFNGSQKAKKLDGQKYPKLTNDGKFIPIRKIVHLDLKGGAFKPSFFPKLFNFFNKIGLTGVLIEWEDMFPYTGKLFDAINGDAYSISDIERILQSAKDNQLDVIPLVQTFGHLEWILKLEKFKHLREDKRYPQVICFGNDEAFDLIKQMIDQVADMHKKYGMKYFHMGADEAFHVGFCDETIEKMTKEGSKEGSKDRVMLWHISRIAKYIKSTHSTTVLAWHDMFGHVAENDLRFYEMTEILEPVLWSYAECLDEYLPFTDWVALKPFKNVWGSSAFKGADGPMKYHSNPMHYIKNHESWISQMTQAYREFDYFQVRVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMF8</accession>
    <name>A0A914YMF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20764.t1">
        <property type="protein sequence ID" value="PSU_v2.g20764.t1"/>
        <property type="gene ID" value="PSU_v2.g20764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20764.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12214" checksum="DBEA446E0C48FEDE" modified="2023-02-22" version="1">MNNKLGEFTDVSVKLNLSLFDEAEIDVLILKYPSLIVITSSSSDAYLLSPKELDKFLLTHIASHSFRLKVEDNCMTTLTIQGQSLIHFLSKVDTFLLSGSMSATHIQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMM5</accession>
    <name>A0A914YMM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2018.t1">
        <property type="protein sequence ID" value="PSU_v2.g2018.t1"/>
        <property type="gene ID" value="PSU_v2.g2018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF3">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2018.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28044" checksum="9782110E5E42CBEF" modified="2023-02-22" version="1">MLGSFGGRTFDTDIIRHDPIIFVHGAGQRAGDFISHYFYFLGKQYNAAELYATTYGDGGITPKKYKTLACDDVKQIHGMIIAVAAYTNRTVNIIAFAEGVALARKAILSGTCVDTRETLGVALTNLVDTFISVAGVGYGKQGCNPQEGGCNLNNGMYCTSAFLTELNTPASRYEGRTSFYIFSDNDNVIGQTCCTNQLCSQLKNANSFSRQRNMLHDSILTLTQDLQYQMIQSRGAFNGTLYDTQYNNGLSWLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMS9</accession>
    <name>A0A914YMS9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2200.t1">
        <property type="protein sequence ID" value="PSU_v2.g2200.t1"/>
        <property type="gene ID" value="PSU_v2.g2200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2200.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16100" checksum="30617F4C454DF349" modified="2023-02-22" version="1">MFRQASRSSFCLVAAFTRSKLPAARSLVTVTYVNNQTQQKWDKSLQQNRFYSAKAPLSLKTVEERIKLVLSLYDKIDPNKLTMDSDFFKDLGLDSLDHVEVIMAIEDEFGFEIPDGDSDRLKTPKDIFRYICDKEDVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNP0</accession>
    <name>A0A914YNP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNP0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21037.t1">
        <property type="protein sequence ID" value="PSU_v2.g21037.t1"/>
        <property type="gene ID" value="PSU_v2.g21037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21037.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17200" checksum="119082EB078C3D52" modified="2023-02-22" version="1">MARAFDQAGVDVQALHGGNHAGTVVDAQVDFGLRRLPQQIGDARRQQVVADGGTGRKHQPQRCTLRRVAASGQLPLQVGSIDQQRARRFQQRAAVAVQGQAATDAVEKRRAEVRFQLLQGGAAGRLRKCDGLTGGSGAAVVGDSDEDLQLAQGQAHGAYLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP60</accession>
    <name>A0A914YP60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21207.t1">
        <property type="protein sequence ID" value="PSU_v2.g21207.t1"/>
        <property type="gene ID" value="PSU_v2.g21207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21207.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14015" checksum="914A6534683DACDB" modified="2023-02-22" version="1">MNENARPGPGVIVALAGAPDRVVAVVGAGGDQEVHGDEQCAGNDFRQEQSDDDQHDVDADHHQRLAPHAQDEQVDGAEEEGEEVDVDLQAVAEGQRLPGLLETRLLGSAVLLEEVEAELPLRAEAGEVDCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPK2</accession>
    <name>A0A914YPK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19285.t1">
        <property type="protein sequence ID" value="PSU_v2.g19285.t1"/>
        <property type="gene ID" value="PSU_v2.g19285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19285.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22727" checksum="C306056DF8BB7176" modified="2023-02-22" version="1">MAELTEEMREKLFFEIITSSKEYTKENITDPKRVKSGILSILRTHRPIKLIDYEYGLSHALMKDYQIIVKEKEDKSKVRVYCKNKKYFYCVKYRQRLNNCSSNLKFKCGILFAAIHHRNKCEAKDYSVVQKIQDLLKQGKNGKALALTFRKNESQNRSPNYDPFLSLSTSIRNDTTGSTPTDGENEMNLEEWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQJ8</accession>
    <name>A0A914YQJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plexin TIG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19634.t1">
        <property type="protein sequence ID" value="PSU_v2.g19634.t1"/>
        <property type="gene ID" value="PSU_v2.g19634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plexin TIG" evidence="1">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19634.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14090" checksum="598632A60442E7B2" modified="2023-02-22" version="1">MHEGKCSAQSECQSGLLLTQKCPQASGSIHPLNHSVNSLQDASVFVPILNLPAPVEGNKNYECFFGAFKSKGHWSSKGVKCRLPEQRPTVSAPNDYVVVPLSVRSSLSRINIVQHNFTFFDCNYYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQM4</accession>
    <name>A0A914YQM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Photosystem I assembly protein Ycf4</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQM4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3100.t1">
        <property type="protein sequence ID" value="PSU_v2.g3100.t1"/>
        <property type="gene ID" value="PSU_v2.g3100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3100.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12867" checksum="9FC8C77D1457741F" modified="2023-02-22" version="1">MIGASIFFAFVLCLIIFGLVGGLFLWNVLLISSGTTYIEILKGQNKNNTSWKLFLFPWLKPDFADIWIDFLNLKNGRTFWRHIALPSAHRPTIPLDWGDDYRSDRLHLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQX0</accession>
    <name>A0A914YQX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAND domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQX0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19775.t1">
        <property type="protein sequence ID" value="PSU_v2.g19775.t1"/>
        <property type="gene ID" value="PSU_v2.g19775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000770">
        <property type="entry name" value="SAND_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAND" evidence="2">
        <location>
            <begin position="97"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19775.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="15759" checksum="184494DA495C10C2" modified="2023-02-22" version="1">MNENDSSTPSLLLDPASTAAAAIAHLQSQLNVQNNISTTANGTQINFDDSSSIYPAVTPESIGDADSGVETKSIDIKSESDHCMMNQDPDSGDDLPPMEPAANARILDVRCGNLTGKLYEERFTCPGIHKKCIEFDGRLNTDGNEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR24</accession>
    <name>A0A914YR24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2628.t1">
        <property type="protein sequence ID" value="PSU_v2.g2628.t1"/>
        <property type="gene ID" value="PSU_v2.g2628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2628.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="28705" checksum="6008943C5D85A628" modified="2023-02-22" version="1">MQPSLNVLTADTLYYDVPSFEHELVEDENDPGIKVLEHSKRILRLATANAIVILIFMVLVLVASSIVTALIYYHYSNRARRWVKITKTMHQRLSKQILREEKLVELCQKIAVSAELIHGERKEICPDIGEMVDLPAVRYVDPFKAPSNLYEQIAEKDEDAKTLKNIDPDVFIKKDDIMSSGGGTTTNPSGKTPVPATPATPVTATAGTGGAGASTNPPSAAPPPAAPTPAAPTPAPITPAGEEQKKTWVNGAIKTRREEKYGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS51</accession>
    <name>A0A914YS51_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">INTS8 TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YS51"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3561.t1">
        <property type="protein sequence ID" value="PSU_v2.g3561.t1"/>
        <property type="gene ID" value="PSU_v2.g3561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038751">
        <property type="entry name" value="INTS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057980">
        <property type="entry name" value="TPR_INTS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25756">
        <property type="entry name" value="TPR_INTS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTS8 TPR repeats" evidence="6">
        <location>
            <begin position="523"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3561.t1"/>
        </source>
    </evidence>
    <sequence length="799" mass="92424" checksum="B61791D34DD13305" modified="2023-02-22" version="1">MGDFIDKLPLLPVSIDLQNFDYFVEKEEFKKELAKRDDGKIIVTIKKSDLYLCCFAGFANLKWDIFRIAQGVPSMRIRSLLKQLILYAFPDRLDLIQMSEADIFKAVAAIPSHEFTEDNLFVAWFYARWILHLDRISRFPSITVKQTVANPAVQPDQVLLTAEQHGLCVQTTRPVTHIAAKFLQQLESLPVDRVKVPTENLNVWEENIEPNFQQSNLYIPMEWIIHRTRFDLFHANYAAAQFRTSRLLLKLLLDTKPDFSSVSPEIRDYISFDFNELQHFATCLAAVSIETQAKAVGYGDFISREMIVDEKAREQSLQICRIQLEKGSDVIETLRLKMAILCIENLNSLLIDKTRKKVPVPSEDHFNKFVNSNPSLFGLFSTIKPDLFEKYFDATNKTKFPAKFPERYSYSDEEVGDFISRVCPKDLQPLFFLLIGKAKQLQDVSLFKNWEQIVTFFLNSVAKSIQPNHPQLKELQSLLILKALNFKLRPAYTTISFRDITLIEEITRKYEILIQTPPLNVKSRKLLFTFNDFLDMIQNICEPVAVKQLLNYTLQIYNRWFLKSEGVSHILLPDVEMKSCFILPDGYKLDSADTRFDNHWGSRKDIVYQILDTCLKVSNRVCSNDAFVLRATGDYTFVINNFEASLRFYLNCVLVLTNHLAHPLTYNNVELIDDLFWKKVSSCLIQVKRPTQAAITCQLITNMFEILPLIHSILFSVDCEDASSAYFHLIGDIAIFELMSAAYIRQGFMKLQQRLVESVLSRSFHSNGVKAIHTHEILRRKSRWIRVLCSDVFDAFDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSF9</accession>
    <name>A0A914YSF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSF9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3101.t1">
        <property type="protein sequence ID" value="PSU_v2.g3101.t1"/>
        <property type="gene ID" value="PSU_v2.g3101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3101.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="23525" checksum="ABB865DF642DBDD3" modified="2023-02-22" version="1">MDNLEQWFLCLLESEDEEFIVHNVEYNLGTDLTNKKLWKLYIKYLKDGKKYHDMVIVYSKYCNFFLDDTEMLKEYQNLKNIVKVKAENVENRFYLVNKQSYNLQMCQKSLHYNIFPQTFTFPTIFIRYFLDTADPDILHNLYQTCKYFYRLHSKPLCHQFVVQKTNVAENLRISYVNITPKTVEIISKLNFGESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSK3</accession>
    <name>A0A914YSK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g369.t1">
        <property type="protein sequence ID" value="PSU_v2.g369.t1"/>
        <property type="gene ID" value="PSU_v2.g369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1430">
        <property type="entry name" value="Multidrug efflux transporter AcrB pore domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1440">
        <property type="entry name" value="Multidrug efflux transporter AcrB pore domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063:SF13">
        <property type="entry name" value="MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82693">
        <property type="entry name" value="Multidrug efflux transporter AcrB pore domain, PN1, PN2, PC1 and PC2 subdomains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="Multidrug efflux transporter AcrB TolC docking domain, DN and DC subdomains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g369.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="18586" checksum="8522AF3CD66F3018" modified="2023-02-22" version="1">MPTAFLPEEDQGYVIANIELPAGSTANRTIETISAVENYFKEQPQVENIIAVQGFSNNGSGKAMGQLLFGLPDSMVIAIVPPAISALGNSSGIDMRLEDRSGMGHDALMAAADQLLSLAKQSPVFDPQSVRITGLGPGKQIRLEIDREKAAALGVNFNEASALIAGSLGSSFVGKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSP4</accession>
    <name>A0A914YSP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2671.t1">
        <property type="protein sequence ID" value="PSU_v2.g2671.t1"/>
        <property type="gene ID" value="PSU_v2.g2671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2671.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14925" checksum="47B42E0D60A18EAF" modified="2023-02-22" version="1">MASELDKIPANVVNLVREEERIRRLHTEALGRYNYLKQLIADKKLQAEFSGASNPAAAAAVAAYMDESIEVEEKNAELHILSTEATMIYYYFEHATNSWLFLERDRINGSSSMFTIQRKGNNNAPNVQVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSV7</accession>
    <name>A0A914YSV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2745.t1">
        <property type="protein sequence ID" value="PSU_v2.g2745.t1"/>
        <property type="gene ID" value="PSU_v2.g2745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2745.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11399" checksum="BDE5B22C2026C89C" modified="2023-02-22" version="1">MKMKKSVEVAPEPQAIAEAAGIRPGSVLKSMNYENLDAEKILTNFGTFGFYQMFVYAMANLGFFLFACETMIFSLISEPEFECRDPELLSQTSETQNMSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTE1</accession>
    <name>A0A914YTE1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-phosphoxylose phosphatase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acid phosphatase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-O-[beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:56512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="Rhea" id="RHEA-COMP:14559"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="ChEBI" id="CHEBI:140495"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTE1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3266.t1">
        <property type="protein sequence ID" value="PSU_v2.g3266.t1"/>
        <property type="gene ID" value="PSU_v2.g3266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3266.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24987" checksum="33DDBD9F98FA0EC6" modified="2023-02-22" version="1">MPEFEDLFVNYIATLWGFISFNNESFDVDLQQELSKISSGSFIAEIIDRLKLKIQCQQNANQTIECERMKNQKFYGYSGHDITEISLLLGLGYETFIFEKHSMPSVSSSIVLELWESEEAENAVITEKNQFEYYYVKIYYYQNSTVESPKNIGNLLPKCQGKGCPISYLIKRAELLCPKPDLKSYCNQAMTSDTFKLNNSLTTLLFISFSLFYLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTV9</accession>
    <name>A0A914YTV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTV9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3588.t1">
        <property type="protein sequence ID" value="PSU_v2.g3588.t1"/>
        <property type="gene ID" value="PSU_v2.g3588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3588.t1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46452" checksum="7996FD96A8D66DBF" modified="2023-02-22" version="1">MFVQKTTNDIFSKIFCDNCVDENNREHCRATHRHDFVELDRFKCIKCQKECHRLCRESFAENTCKTCQPIPFRFNAAPLSESSPSTSAQSSSSSTAPATLIEINTVILKQNNCFTKVLGQKKFKFSKPDLLQKAIEYVKMLRLEQKLGEDEAMNQYYFNLSNCNLKIYGLFHAHEEGDLLMAIAFVEEVGPRCLIEVLAFQATISSIKNVIKKEIITSFFVELVKIQRNLNEFVHIRVAEGVRGYSGEIFENISNQLPKINIAVKKLKDSLVNTSSLFQIPCFSNDPKFLQIINVIHELGFKINGKLPKLRSHLSLEAAAKNYIAQLTNEIVVNGLTKKMIAKSDSAKENGSEEKSLSILSINDLLQAMEEMHLKFSDIQNCCYSTFKIVGLFFGKSKIRIIITKSKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUH3</accession>
    <name>A0A914YUH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3315.t1">
        <property type="protein sequence ID" value="PSU_v2.g3315.t1"/>
        <property type="gene ID" value="PSU_v2.g3315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3315.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="12816" checksum="25A7079AC79B40E8" modified="2023-02-22" version="1">MQLVGDIKGDAKILMGKIDHEGGRKISAEDFVWPGSGEVTFTGGGTAHHFDGNIEGKIQGFAQNGGFCRKRIERDAHVVVDELNADPHARTASVDQLTAHRHQDQCGTFNLFSGAASQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUS6</accession>
    <name>A0A914YUS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3422.t1">
        <property type="protein sequence ID" value="PSU_v2.g3422.t1"/>
        <property type="gene ID" value="PSU_v2.g3422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3422.t1"/>
        </source>
    </evidence>
    <sequence length="441" mass="51110" checksum="F58403A9C2CC7986" modified="2023-02-22" version="1">MFYSFYWKRKDLPPGPTPLPLIGNLFSIDKLGLERFFTDIKDQYGDIHTFWFGENPIVSISDVPTILETFVKDGDTFAGRPTNMLVTDMTRHGRNGLIFTDGPLWREHRRFALHVLRDFGMGKNLMQERVLDEVTILIDEIKKQISAGHKHVSVQDAIDLAVGSIINALLFGYGFSKNNTDEFYELKTHLRDFMRAVGNPLVRFCDRNPFMFKVLPFIYRDLTRTTNKLEKFFMKQLEAHEKEINFDSDIEPTDYAEAFLKKRKELEVEGLKDHTFTNKQLYAACLDLWIAGQETTSNTLAWMVMYLMLNPEVQKKVHAELDQVIGSDRFITVEDKTQLHYINATVAETQRFCNLVPLNVNHRLVKDVEIKGYRIPANTTILHQISTVLFDERYFPEPLKFKPERFLDSEGKFFQPSSLMPFGVGKRACLGEGLARLERDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWE0</accession>
    <name>A0A914YWE0_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWE0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4871.t1">
        <property type="protein sequence ID" value="PSU_v2.g4871.t1"/>
        <property type="gene ID" value="PSU_v2.g4871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4871.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12461" checksum="9182249D42405E15" modified="2023-02-22" version="1">MALLRKKLEPVKYVELVKAEGDAAKPPVPVVPLQIPAEDFDPSLAKKPSFQSATKAPAANDADKENELAPEGGSAAAAPEPEPEPEPEPQAEPEPEPEPEPEPEPVEDEPAAEEEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWI2</accession>
    <name>A0A914YWI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2440.t1">
        <property type="protein sequence ID" value="PSU_v2.g2440.t1"/>
        <property type="gene ID" value="PSU_v2.g2440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037134022" evidence="2">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2440.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16732" checksum="5681288B4F8B92C4" modified="2023-02-22" version="1">MKYIILLFVFVLAVGGNPALMTSNTYPGSSSSGQYQYQNQYPNQQQQQGYPNQQQQGYPNQQQQGYPNQQQQQGYYRRPVYRDGMITPVNYTPYLRTRNVNPQEQEMRILPYPSQYTAQNRNNNMQNQDMNKQNSNPRPDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWX2</accession>
    <name>A0A914YWX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g415.t1">
        <property type="protein sequence ID" value="PSU_v2.g415.t1"/>
        <property type="gene ID" value="PSU_v2.g415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037309622" evidence="11">
        <location>
            <begin position="24"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="15">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="236"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="352"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="469"/>
            <end position="583"/>
        </location>
    </feature>
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        <location>
            <begin position="582"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="646"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="707"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="768"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="827"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="854"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1006"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="1174"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="1288"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="16">
        <location>
            <begin position="1459"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="709"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="770"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g415.t1"/>
        </source>
    </evidence>
    <sequence length="1528" mass="168113" checksum="6EF6AB94754CEF6F" modified="2023-02-22" version="1">MGFQAAMASAIFAVVLLANSGLAQYSQRNYQFNSTFSKAALTDISLKCPEGWELEGSKCFKVYHLEKSWPQALFFCGRYGSLPARIESQKENLFVTKLLNRPLRSASGTLKTEYWIGLVVDPNLSDDAMFMWSDGSMVSRYTGFWAKGQPDYRTGGCVKASTVNSNGSPLSSIAWHLEMCNMLFPFVCELPACVKGSFFCHNGGCVPESSHCNGIDDCGDLSDELNCPASHSDLACLKYEKGESGKIQSPNYPSSYRANSNCRWVIEGPVNSRIQLTFDSFETEENQDIVTIVDGGPSENASLAVDTISGTPKLDRLSYTSSTNMMVIRFRSDALIQARGFQASWRAVSFSCGGRLKAQLYAQSFSSPEYPHEYPNGLECVWRIDAPQGQLISLNIDNYDLEDENDFVVIYDGAKSSAPILMKLTGRQLNDTANLSQLLISSQSHLYVYFFTNHAISGKGFSISYKRGCDNVIRQSHGQLLSPGHTRVPYPPSQTCKYTIELPENREDQPISVAINHFDIASDDNLQVFEGGEYGRALHENNGFNENTRPPKMIFSKQSKLELVFQSNSVRNSLGWNVTFSTNCPPLDIPSSVVVSTHNTAFNTKVFVSCSDKGYEFINGRGRMFELQCLLGGRWTENRIPTCQPVYCSPVPQIANGFAISATNVSFGAIAKYSCYDGFSFSSGRKSEEIICNEDGKWTAPPQCKAAACPALISFTNGERKLLFGDGTSFGTVYSFECAAGHRKKGAATILCQNNGEWSTPQPRCEKLVCTNISEIQHGRLLTKEQGHLEFDGTAKVECNPGFKSDGVDSVKCLANQTLSTVPQCIDIDECKEQTASCSVKSTNCNNLPGGYFCECKQGFKPQLACQNAVSLLSMNVVSSSEGPSFPASKHSSTGWCALKDDTRRTLTFTFAVPKVIERLRIEKTAGAAYPTRLRFNYAMEDGVKLKTSSRLTNMTTRNVGIAGSELLVLDPPLEAKIFQIVIEEFKEAPCIRVDLLGCQKTSCTDINECDENNGFCEHHCINMQGTYRCSCDDGYDLFMSDGQNGAKIKEGETGNNIHDAVRFNKSCVPRQCQPLTVPENGQLLSTANMFHFPNIVEFRSAVCNGAQNNTAIGLFVTPEGQIPYGHNVSVVCSQQNRPAPISPLAGFRQCIYDPKMDGPEYWLSGPSIFCPLVDCGPPPVLAGVYYEGDDNSFKVGSTLAFSCRPPYSLLGKSSYDDRIIRCNVDGSWDLGNLRCEGPVCVDPGYPDDGTTQLESVEEGAIARFSCNRPGYQPFPSSAINCTLGTACVLSEDVGISSGFIPDGAFADNSDTTSWGYEPHKARLSSTGWCGSKDAFIFLSVDLQRIYTLTTLRMAGVAGSGHLKGHVTKMQLFYKVQFSQNYDTYPLEFETPSGNHNKMYQFELNPPLRARYVLLGITEYETNPCLRFDMQGCLAPLSAAHEIPTHLQVGWNSSVPQCIDAEPPVFQNCPQNPIFIMSDEFGQLQLANYTVPTATDNSGSITFMRIQPTNFVPPRPITSDTDILNHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX12</accession>
    <name>A0A914YX12_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vesicle transport protein USE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">USE1-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YX12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4644.t1">
        <property type="protein sequence ID" value="PSU_v2.g4644.t1"/>
        <property type="gene ID" value="PSU_v2.g4644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4644.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24815" checksum="D4D8F9045B15466C" modified="2023-02-22" version="1">MLQVPSEELNFQRLLHRCKKLSRDALSENKFRLQSSLEVLEVLFVKLQDDKQLDSDILMQYGRELQNLKVMIDIEKKRTTEEKLAALSSLPRTFSTEEQTIRKRRKHSQDEDIYVENEEQVSNAIIKVQNEAVYKADIRRQLMAGSKVHEKAVENMQEGNFITSQENQQAELSEELLRLAGALKQNAQVAGSVLLEDNKISMLKSVRPLTIFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX60</accession>
    <name>A0A914YX60_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914YX60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4698.t1">
        <property type="protein sequence ID" value="PSU_v2.g4698.t1"/>
        <property type="gene ID" value="PSU_v2.g4698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056053">
        <property type="entry name" value="DUF7636"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056654">
        <property type="entry name" value="DUF7752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF57">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24642">
        <property type="entry name" value="DUF7636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24934">
        <property type="entry name" value="DUF7752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="12">
        <location>
            <begin position="211"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7752" evidence="11">
        <location>
            <begin position="375"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7636" evidence="10">
        <location>
            <begin position="506"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4698.t1"/>
        </source>
    </evidence>
    <sequence length="630" mass="73061" checksum="E1496942D3DB8186" modified="2023-02-22" version="1">MFEAVDIELLHELIDVVVFSGKGDRPNSNEMSGANLDGDQFKVIWDPEFILHHNEKSFDYHFPSATEIPESFNDPNSDNTVSDLMIKSFKTFIMEDSIGAISNAHLANSDIYGIFSETCSKIAVKHDKAVNFQETGIIPDGLTRQWSEDGMQPPEKVERYPNFMPKIVASSYKSVRFLGGLHERLLEFKEILKHEKCDSDEIIVDPSFVVSDDQVYYDDALKLYNEYSILIQNLCESYGIQNDGELFSGHFIALKNRLFERDEDKMSFFNTEYIIEEQMANIFEQIRIKFFEKSGELERNTEIDDKNGLGIPRQAFSPICFAPTSELCKKASAFYRVAYERKNIYQFDIFCRNMDEAMHLRVSNDFVSLPSAQICHHNNGLRKLLFFIRKWGAKQRLDEICPKSLDALVILFGSGRFDVTSEPYITIPYYRDDPVDDLENKNGGLGRIFLNFIQGLLTQKFISSDVFSLLPFSKRVLPKHQCLMLHYKAIETVYPIAFNRIFHTLPAEMFVIEMPLESENYEELLKKLGEKCGCKYVTFKIKSEPRSKFRSNFVGFHLFYFFVGKKTFRVALQAVGTFWATWKFREILLPPPNMNEPNFEQRNALLGDEAYKRLQFFISEENSIDDIYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXY4</accession>
    <name>A0A914YXY4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">E1-like enzyme which activates ufm-1. Required for interaction between ufm-1 and ufc-1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with ufc-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4816.t1">
        <property type="protein sequence ID" value="PSU_v2.g4816.t1"/>
        <property type="gene ID" value="PSU_v2.g4816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000066">
        <property type="entry name" value="Putative ubiquitin-like modifier-activating enzyme 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="65"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4816.t1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45866" checksum="0ECB465066A7A516" modified="2023-02-22" version="1">MSSNDVLEKLAKLRSKVRDIGSKSDGGSSFTTITAAAAATRASEESKARSKISEMSAEVVDSNPYSRLMALKRMGIVKDYEKIREKTLIVVGVGGVGSVVAEMLTRCAVGKLILFDYDKVELANMNRLFYQPHQSGLSKVEAARDTLLHINPDVEIEVHNMNITTMENFKIFVNRIQHGNLDNGKVDLVLSCVDNFEARMTVNTACNEENQIWIESGVSENAVSGHIQYIEPGKTACFSCLPPLIVASNIDEKTLKKDGVCAASLPTTMAVVAGFLVQNALKYLLNFGTVTNYLGYNALADFFPNEEIRPNPNCDDRFCRQRQNEYQERLANEPPKEESVEEEQPIIHEDNDWGIELCDDNSEEIPEETSTVAGKGLKFAYDAPSTTSLQQQTNGETTSKINAADISSLMAQLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYN5</accession>
    <name>A0A914YYN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor cactin central domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5064.t1">
        <property type="protein sequence ID" value="PSU_v2.g5064.t1"/>
        <property type="gene ID" value="PSU_v2.g5064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="2">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5064.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="18244" checksum="388039C08365AA4D" modified="2023-02-22" version="1">MKDIETPEEKRIRRMAKKMRKEEKRKAESLSDVIAYNNLNNPFNDTNLTQPFVWGKKLQKEGKEKLSNKEIEKLHMEKVTKNIREMEELRRNREMRRMQKEDDEMMARDREKQMYGDFGVVEYKFHIKQAKERTKIRLKENRPKPIDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0U0</accession>
    <name>A0A914Z0U0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 186</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0U0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5974.t1">
        <property type="protein sequence ID" value="PSU_v2.g5974.t1"/>
        <property type="gene ID" value="PSU_v2.g5974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5974.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30289" checksum="5EB110060643D10E" modified="2023-02-22" version="1">MLSKSVGLINVVRRAPSCSLAGIQKSHFSRNFNFNVKEVRPLENKQKCSVFGSNVLFKQRIVGFSCRNFSTEVTEESGKEKQKNEFPGVWENEQWNLVVGFPPGMFFQTIVTKMKFFYKCISAVIIPWATYSYTTGYLSMNYLAATYGSIIIAPLTLYAFSRALNRMAVYILMEKSNENILVGYFSTFLTLKQDVVPIDDIYSLSAAEKMGKNIQGLIISKKSNNVEWFYVPSKGIKIFDKEKAEKIFHNLDMFSEEVFKYKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Q6</accession>
    <name>A0A914Z1Q6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Q6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6042.t1">
        <property type="protein sequence ID" value="PSU_v2.g6042.t1"/>
        <property type="gene ID" value="PSU_v2.g6042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF279">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN UNC-105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6042.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42468" checksum="E2A8BE1ED7658DA1" modified="2023-02-22" version="1">MQMVTIHDKWIVPFPDAFGHSAPTGFMSSFGVRMKQFNRIAAPHGHCLDGGENSEDFIYKGFNYSVEGCHRSCTQREVVRVCGCADPMYPANKKIKTCSVSDPIARNCIKNTTEYLGRLIAEGTVPNCTCHQPCREIGYEVSYSAARWPSGTTKLMECDVTDDLCMEKYRKNAAMIQVFYEELNYETLTETPAYTMSSLLADLGGVTGLWIGASIVSLLELVVLGFYCCKAYKKNRKLSVEANAPYTIGVPPYKKTISISSSSTSRPPKKKTSSSRSVLSKHSILDELIHQQSSLPTLPSENEASDENEETPPRKYSSPYLPPGADLPCICLFDMTGRITKMKALCPEHGYMVRRGTGYSMGDDEGEEEEEAEGEIEGDWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1T9</accession>
    <name>A0A914Z1T9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B9 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1T9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g587.t1">
        <property type="protein sequence ID" value="PSU_v2.g587.t1"/>
        <property type="gene ID" value="PSU_v2.g587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF1">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g587.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29893" checksum="D9E780E1871FF45A" modified="2023-02-22" version="1">MQRAGPSASSSTTPKSKFLMMVTGEISVAEMINVQTIYCKYFYVFGTDWKFIGGIKEGVSATSSKGVHHKIALNTPIEATFSSTNPFKWPQIVLACYGPDLFGNDVIRGYGSAFLPTVPGRTERKVAVFVPEASTTMHKILGFFTGRRAEFVDPRTVSTSEGREVTRVSTQGLITITFDIVLKDMKKFGYDVIPQTLSRVSDFPMPVFNEAERPRRASKTPSEIPKAEVTEIARDETVEAIRSPDVQSPSPVEEVDDQRIVQYEESQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2T0</accession>
    <name>A0A914Z2T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2T0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7016.t1">
        <property type="protein sequence ID" value="PSU_v2.g7016.t1"/>
        <property type="gene ID" value="PSU_v2.g7016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF97">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7016.t1"/>
        </source>
    </evidence>
    <sequence length="673" mass="75501" checksum="7793EAF27894EAB6" modified="2023-02-22" version="1">MLFCSVLGVVCRAYYLKQHSRSKILLALASCILPLLACGTALALMTTIGFRFSSILCVIPLLVLAIGIDSSYLMIHEWQRIIQQCRDNPNEENAQIGYRIAEVLSEVGPAIMISALTNMLADAVGAFTSSPEITLLCVGNLLSMGVVFIYQMTFYVGLMSLIGKHEIKMEEKNRNNLKNIEDVKNVEAVNQIKFTSPNAKPAKKEEISKTMWTYVSLIANKFIASFIILLYFAYVLFSVYGITQINIHLSTQKLFPQDSPLLTLDKLRIKYQVPHFTMATVFINNPGNFSNPTRLQRMNQFVGDMEQLPGAWGPVATKYFIRDFLQFENIDVDNFEEVENETSDIKNNSTILPSPAQALKETNALASLYNDEDLPSFISWPEYSFWSGFIRLKNQSIIIKEEEEEKKVMNDSKLEKFFFTTAFHGKELSKYVKLGHALNRWRSVVDKYATEFDATVFHEEAVFLDLINNIPIDTMQAVCGAVICIGFVCYIFLNSWFAVTIATVSVLSICTGILGLISWWSVDLDPISMAAMIICVGSSCDLPAHTSFHYYLATVREGPRSDPKVKLANCLSTIAFPAIQAGISMILCVCALLFVNIYMSIVFVKMMFLCVVLCNLHALVIIPAFLVMFDYIRFGFNSQKRVGPKEDDSIDSLPHSDSDATEASTKNITNIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3P3</accession>
    <name>A0A914Z3P3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3P3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6514.t1">
        <property type="protein sequence ID" value="PSU_v2.g6514.t1"/>
        <property type="gene ID" value="PSU_v2.g6514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6514.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8219" checksum="C6FBBF64CCA2657C" modified="2023-02-22" version="1">MDQTEAPIASKSEMDMVEKLEKEHPARSSPIVEDNDDETSGEDDEDEDDEEEEAIVIDKSHPSLIQSSSRTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4T2</accession>
    <name>A0A914Z4T2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arrestin C-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4T2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7366.t1">
        <property type="protein sequence ID" value="PSU_v2.g7366.t1"/>
        <property type="gene ID" value="PSU_v2.g7366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016060">
        <property type="term" value="P:negative regulation of phospholipase C-activating phototransduction signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.840:FF:000002">
        <property type="entry name" value="Arrestin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="201"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7366.t1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42206" checksum="2F2684DC52508B58" modified="2023-02-22" version="1">MSDLDDRKAGTRVFKKTSPNGKVTTYLGKRDFLDRGTFVDPIDGMVLIDEEYIKQGRKVIVQLNAAFRYGREDLDVLGLTFRKDLIKQSFQVYPQDSALERPLTRLQERLKKKLGDNAFPFWFEIPPHSASSVTLQPAQGDTGKPCGVDYELRTIVTGEGACVERPRKYSTVKLAIRKLTYSPAVEGPQPMVDVTKEFLMSPGLLHLEASLDKEMYYHGEKIAVNVHIQNNSNRTVKKIKVSVVQTAEICIFTTAAYSCDVDKIESSEGFPVGPGGTLSKIYYLCPLLAKNKEKRGLALNGQLKHEDTNLASSTTLSATGCTKDVLGILVSYRVKIRLLIANALSGEITAELPFTLTHPKPFEEDSPPMEPKRRVRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6B5</accession>
    <name>A0A914Z6B5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-lysosomal glucosylceramidase</fullName>
            <shortName evidence="1">NLGase</shortName>
            <ecNumber evidence="1">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-lysosomal glucosylceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z6B5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g787.t1">
        <property type="protein sequence ID" value="PSU_v2.g787.t1"/>
        <property type="gene ID" value="PSU_v2.g787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014551">
        <property type="entry name" value="B_Glucosidase_GBA2-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024462">
        <property type="entry name" value="GH116_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052566">
        <property type="entry name" value="Non-lysos_glucosylceramidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654">
        <property type="entry name" value="BILE ACID BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654:SF2">
        <property type="entry name" value="NON-LYSOSOMAL GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12215">
        <property type="entry name" value="Glyco_hydr_116N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028944">
        <property type="entry name" value="Beta_gluc_GBA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl-hydrolase family 116 N-terminal" evidence="4">
        <location>
            <begin position="134"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl-hydrolase family 116 catalytic region" evidence="3">
        <location>
            <begin position="502"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g787.t1"/>
        </source>
    </evidence>
    <sequence length="941" mass="107793" checksum="4D7E65FC0AC378D2" modified="2023-02-22" version="1">MVKEDTQLPSSDIFSSPTSSFNSDHLNSPISPTTSSMTCKQRTKELKKIKRIPIKGPNISPNEEGLGGEYGWIARGDREPEEKRVPFTKPTVKQVVSAIPFIFRYSVFWLKYLRQKEKLFINTFQPLKHRPYYGVPCGGIGAGSIGRDFRGAFCKFSLRPGFVEQRVNAVKGNQFILNLSRNGKTIKQTVLSCAYNSGEAPLSSWDFTFPSENVAYRGLYPRSWTKYDLPEYGITVICRQITPIIPNNYKDSSLPTTVFVFEIMNNSDEAYDATITFTWRSGTGKRRFSDEGECQTAKFQNEHICGALLDHTIDKMQCIYAISALETDENQATICTGFNPNGNGSNFWMQLFENQGKLNNGKIEADNSSSAIATSLTTHLKPKQKRDLEFSLIWHMPIVTFGTKQRNFKRWYTRFFGTDPDGVKAIAEHALKNYKKWEESIDEWQNSILQHPNLPNWFKSALFNELYFLSDGGSVWFDFDENWSDQEKQLSEYTKKLLKEYGRFGYLESWEYRMYNTYDVHFYASFALAELFPKLEHVLQAEMSDNIHNSEEKLIKYHMEGDIAPQKTACRVPHDLGNPACEPWLLTNAYVMHDTALWKDLNLKYVLTSYRDYYCMLKKDKVFLEFAWPSVKALIEEGLTNWDRDGDGMIENFGLADQTYDAWRMVGVSAYCGSLWLAALKVSTEMAKDLEDTVALEKYSKILEAAKKVFEEKLWNGKYYNFDESNISRKTVMADQLCGYWYLQSINPELAKDLLPAEHVHSSLSYIYEYNVMKFGNGRLGVVNGMRPDGKVDKAYIQADEIWTGISYAIGAFFIQQGNPQKGFDVAWGIYDTCFNRSGLQYQTPEALYRKKYYRAIGYMRPLSIWSMYAALRKKYKLLENDPSTLAGIRITDPIIKDISNISSLEDASSDSEIIDIPNTISELVIADSSNVQTLPSSIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6T1</accession>
    <name>A0A914Z6T1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6T1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5958.t1">
        <property type="protein sequence ID" value="PSU_v2.g5958.t1"/>
        <property type="gene ID" value="PSU_v2.g5958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5958.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13288" checksum="974CD38C7F53B0CF" modified="2023-02-22" version="1">MTVARSYEFEVKEQVGSKKAEAGVNAVGPIEVDPAYRIDLSKSEITDEEKQQLKALLEEFEDVWARSAYDLGSCQFECPTLKTTTEVPPKVRVHRVPHKWKNELNTHLKGLLDTGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7S5</accession>
    <name>A0A914Z7S5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7S5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8379.t1">
        <property type="protein sequence ID" value="PSU_v2.g8379.t1"/>
        <property type="gene ID" value="PSU_v2.g8379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000112">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8379.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="33745" checksum="A6931D8E2D9B3F0A" modified="2023-02-22" version="1">MQMQAAAAAAAHHQQQQHHPSHHHGGGLPPTIIPSHFQNHPYLNLSDALMMKMGITPPSCNAGSDTESSPASVEQRSPLDLKNSSSPNSSIATNETLPKKILSPLDLTTDLKSDEMICVDDDIPSSSTSVIQSTSSLHSNNNEEKKSFLLDSSAKDEPSTSQQSSPRPQTFFTKDCSSSELPTMINSFTPNAFFNMFQRGPFGQTAATHQQHPSAAAGGGNNYMGLLQAFQPPSMNPSTGIHHLHHHHHRHSTTNSTATKIPLIPTGPRGSKERYTCRYCNKVFPRSANLTRHLRTHTGEQPYKNFKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8P2</accession>
    <name>A0A914Z8P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine/putrescine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8P2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g870.t1">
        <property type="protein sequence ID" value="PSU_v2.g870.t1"/>
        <property type="gene ID" value="PSU_v2.g870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g870.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13303" checksum="B0F770A8E4EB2AFA" modified="2023-02-22" version="1">MLGGLALAAGSAQARDLTVVSWGGSYQDGQREIYFKPFAKELGKPVLDESWDGGYGVLQAKVKAGETNWDVVQVEAEELELGCADGIYETIDWEKLGGKDKFIPAAVHDCGVGAIVWSTVALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z926</accession>
    <name>A0A914Z926_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z926"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8830.t1">
        <property type="protein sequence ID" value="PSU_v2.g8830.t1"/>
        <property type="gene ID" value="PSU_v2.g8830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8830.t1"/>
        </source>
    </evidence>
    <sequence length="527" mass="60745" checksum="346953CB3E8F865F" modified="2023-02-22" version="1">MLFARASLTNESDIEEEDEIEVVAADIPSTSNTTDNSIKLNKFNQKKSVRTENINDGIQPCSSKTPIWANISQNGIQNHDLTQMPSTSAAPGSSNVLKVGLEYRRHLPPQMRHKHPYVAYKRFRDAFSDTLGTKYQPPGIDPSLYEIIKDRISHLLPSEEELRDPNSLPFKRYRKALSQELAKAYKTGELPEDDTLQYAILNHEIQMNEIIIDQIEDKHRIESDRIKERDKITRRMIEERYEVEKEKVEKQYETAVAQLAEKMIAENEEERRQLEAELAVIGEDGEVPANFNYLPNRKQLRRRTGNLNDSSSVIEHSDKIDPYVPIHQVHWIDPNDINNDLNIFNSVLQSFSDEGPFEKHLSMQIQEGKLLIASSQKNNPVVFDEIRLSNFKTKKVKVTLKIDINSFHDLKVEPIDEDIMDEKLSKMNLSDVQFRFVFDKQNFGVFAVKDDKEQIQIRASNGSEKIPIYIAFTDKKPVIGKAAKEAYAQHPKLVVFGKHHLFVFYLMYLTGKFQILSNFAPSQMVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9E0</accession>
    <name>A0A914Z9E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9E0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8427.t1">
        <property type="protein sequence ID" value="PSU_v2.g8427.t1"/>
        <property type="gene ID" value="PSU_v2.g8427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="225"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8427.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="42081" checksum="89FE930A73E0DD63" modified="2023-02-22" version="1">MNRLLPSHHPTMSSRPINLDLHRYNNNRSELLAHEAAYIKTNSSTTKRNGRQYGFINRNYPISNDSSDSENDFNNLQYSSSQRQYRSRQKQPQSRTLEMIQEISPVLPDNSDNDSELPPRMPLRYTKEFNPLQTSTLLSLQNSSQQQQHHQQQHHQQQIYQHHHHPRPITNPHHNGPSTPSSYNPISLDGGDRIPSLFENQHQRLHPVSSDFFGLSSMLATKFNSNGILYLEISILKNVLSVKIRNASFYFDKGFHGQVNSYVKVQTKPNPDKQRRRRHDDDDRFESFQTKIIKRDNRPKYFQTFNFKIRSRNREALDFLSISVYIVEDSPSGRVSNLLGCMSFPLERLFRKAGIYDRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9U4</accession>
    <name>A0A914Z9U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9U4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8693.t1">
        <property type="protein sequence ID" value="PSU_v2.g8693.t1"/>
        <property type="gene ID" value="PSU_v2.g8693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8693.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19490" checksum="31F79B6FAC9BCD2A" modified="2023-02-22" version="1">MLKCITKTKYKNNDFDDFVNWLNDSGAQSARFESDRKSRSLEEHMQESLRVRQPLQRSSRIEHARSESELIEGQRPSIEYASPQSLGAIPENLSQQQRPSTSGSLKSKALRHRAQSVAAGKINGFLGSRRTSSCIRQNTEPRNNSQRKSLANLASMRATSSSSSARQPRRNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAQ0</accession>
    <name>A0A914ZAQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAQ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9741.t1">
        <property type="protein sequence ID" value="PSU_v2.g9741.t1"/>
        <property type="gene ID" value="PSU_v2.g9741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9741.t1"/>
        </source>
    </evidence>
    <sequence length="787" mass="89857" checksum="1658A523A049D4AF" modified="2023-02-22" version="1">MQRSTEGSHPELQPQLPLDDIAVANVHSVLLRLSQRLSTLDGVEYEDHTVSDRTRVMKQTISEILRRWDNTLDQHRIQYIHTVFEELETIHANAVVVKRVTPGDGAELSDLVGPQHTSHEVPAENWASYALVRRRQKQMIGGKYRYDGEDGMFKVEVPCSYRCKKCLTNDHAEIECAEQQPTCLKCRRVGHVSGYCQWQLCAWCKQYGHGRQKCQSSLESPACLKCGKTGHDPIACPNSGRNNLYCRICRGPHSMFKCVDYERLGKPCFKHCGYHTFAQHAEVQMDVKALCVTFIDTNCFNGIESSYTVVQDFHFTLLRLCITETVLTPKIGNIQVCDEFFRRVYAIPNGRYMRLCNQVLMSLNRPVQHGNEGRIRQKESVFQRTATLVNILIEVAEPMPDGKGYILPSSMTKAIAKSLHFQKSNAFTKCNVCLTIRLGLLQNRFAPEYVQKAKKFLSEHLEHIKFEKQDYYVRMQHSRSSNSLLSIAHDGMSKDKTKWPHLLQDRPKKLTDTLKMMNSLNLGVVHKISNGTLGDQLHAFWNIDQMAGGTSNTIASQLFDILSNCHYIPPEISIQLDNCAANKNYNMLGAFGLLLLWVPKIQKVYLCMPQVGHTHDDVDRYFGILARVLQKKQVYSPFEMKSLPLYIKDKGKPEEFRNLLDRIKSRAVIIGTDSQEIQLTTEPEGEKLMDFLANPKIWKSWRPSEVELNEFADELELSTSPENPSEKGQKKVSQQPRKKRKACEISNKKSNAAAKTKRSKVQDNLPASQEQSTENVPKRRGRPPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD39</accession>
    <name>A0A914ZD39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZD39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8174.t1">
        <property type="protein sequence ID" value="PSU_v2.g8174.t1"/>
        <property type="gene ID" value="PSU_v2.g8174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8174.t1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41251" checksum="F8CD10F80551261D" modified="2023-02-22" version="1">MIQEGTIIKPNEIDADFRERLETLKRYANAEIEKCDELIQEREKEVDEYKYLRKKVAEFPKVLRREEWLPINDYAFIRGTYDNTNKFYTLLGSQYFAERSSIETVEFIERQIKAINDIKEGYEKQKELAKSRLEFAENLFDQQNSDVVEIREPYDIEKLKVKLPPKEDVSNADFGAIMSRLNELEKEEENENIETHDNIKDESTANIKPEQKNKESKGVAPKGVSQEVKLDFEKLIKQVDEMIESSSDDEEDYEDEDMSEEVEDFLDSDDSLPDSGNRSVTQKEAQLVTSPPKSTVSTTKKSIVRFAEDLEAGPTVGPVSSTTPKSILRNKDVKTPVDEAAVKAMDEVVPERKILPATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDC2</accession>
    <name>A0A914ZDC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8262.t1">
        <property type="protein sequence ID" value="PSU_v2.g8262.t1"/>
        <property type="gene ID" value="PSU_v2.g8262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8262.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22151" checksum="48A468794C4CD806" modified="2023-02-22" version="1">MKIIPSKKRQEDDEEEGEEEDETSTEEVAAVPTEETPTQGSSLSTAPTTTPTTSSPLISVAGATPETSSSSIPKTSPPPILAPPPLTIITAEDNQEPSSNSKPVLPFSKAASDEKKKEESSDQMSSLKLFKNIPGKPKESIFETKHPNLHAVDKEYLNILLETKEKYSKLLKTHMKCVTEDELKAREKSKLNFFGGAVIIRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGJ8</accession>
    <name>A0A914ZGJ8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZGJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9410.t1">
        <property type="protein sequence ID" value="PSU_v2.g9410.t1"/>
        <property type="gene ID" value="PSU_v2.g9410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9410.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="23037" checksum="64AB8F980B17755A" modified="2023-02-22" version="1">MAMIIVPQKPWEKPIGIGLLNEPQSNASDIPILQQYYKDAYVRIRQNVGSDCLLTVMPMLWQQGPYDGNWATFMLAPDYYNMRHEWHDYHVWGFGADKWTPDKIITWINSVETKYYDEWKGNGLFVGEWCIASQFNMDDKTLKRFADAQIKMFKKAVGGWTYWTWKYYEYPLTVDTKREWSMKAMIQRGMLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XPW3</accession>
    <name>A0A914XPW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XPW3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10055.t1">
        <property type="protein sequence ID" value="PSU_v2.g10055.t1"/>
        <property type="gene ID" value="PSU_v2.g10055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF221">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10055.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17476" checksum="6B7A0A51812400A5" modified="2023-02-22" version="1">MYCWDKYKKRLMRQFFGDEKERQEFEDFVNLCEKRGQKCDHTGIKHEPKKYDSKLACRVKFIDEYVDVSSLNDLPEGTIPCFLDLAAIFYQNCNRNEFEKLLKIRETQKSLPIAEYRRHILDTLKENQILILAGDTGCGKSTQALLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSQ1</accession>
    <name>A0A914XSQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSQ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11003.t1">
        <property type="protein sequence ID" value="PSU_v2.g11003.t1"/>
        <property type="gene ID" value="PSU_v2.g11003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="77"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11003.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16863" checksum="765F369992FE100E" modified="2023-02-22" version="1">MLFGAWAKKEPIPITAHSYNDFKEFLTFLYLGKCKIDMDNVMAIVDLAESYNVQLLKDKCDQFLTHTDPTPENVFKICETLKIYSLQNALDNLYEYITINAVILLKNQSFLEVKKDVLMDIVKLERLVIKEEDLFDSESLKFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTK8</accession>
    <name>A0A914XTK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BCL2/adenovirus E1B 19 kDa protein-interacting protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NIP3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10598.t1">
        <property type="protein sequence ID" value="PSU_v2.g10598.t1"/>
        <property type="gene ID" value="PSU_v2.g10598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097345">
        <property type="term" value="P:mitochondrial outer membrane permeabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010548">
        <property type="entry name" value="BNIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15186:SF5">
        <property type="entry name" value="BNIP3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15186">
        <property type="entry name" value="RE48077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06553">
        <property type="entry name" value="BNIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10598.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20773" checksum="2C1179EE13AA939D" modified="2023-02-22" version="1">MSFFDRQPAMFDAKKRLGQTNQEKNSDEGDSMPESWVELAPSRQSLCSSVEAVMIEKDSNGEASNSKDSRLSPVSIQSPHVEFEQNLEQVKYRLAKDMQGVKSTDWIWDWSSRPEANPPNRMLRHRSGQIGSTLTTPPNSPEPELASEFDYKVDKSSRSVFTRLEVILGLVVSNIMTFMLGATIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTP8</accession>
    <name>A0A914XTP8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914XTP8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10639.t1">
        <property type="protein sequence ID" value="PSU_v2.g10639.t1"/>
        <property type="gene ID" value="PSU_v2.g10639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10639.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42506" checksum="6E508000CD51CB44" modified="2023-02-22" version="1">MGFGNFSLAWLCYETKKNSKKFVALKIFKASNKSTNEEIKILKKVKNHDHIVQYFRSFTIKRNGYAHDCVLFEPLGGTLLSLLKRVNNGVKAQNAGLKIEAIKKVTRHILLGLQHLHEVMKFVHTDIKPENILVNVTDRSLFLAVKDVYDSNCDKKGMRAVSLRGKEFKNGLKKVKADLDKILDNIPLPLSVESAAKIQNRDSVSEEVCWDVIKFKLIDLGNAVSPSNKANTSGTFEYRAPENSFGAPITYTFDIWSVGAVIVELATNCQMFSSVNNTHDSRDLLTTITRRLGKVPYDVYKEFSDPSKLLNDFSTHHSILWSQRSNLAKRFSLEYFSKDEINKMVNFLTFVFNFNPKERPTTSQCLAHEWLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU06</accession>
    <name>A0A914XU06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phasin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU06"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10456.t1">
        <property type="protein sequence ID" value="PSU_v2.g10456.t1"/>
        <property type="gene ID" value="PSU_v2.g10456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10456.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11194" checksum="CD67C825CC2F2ABB" modified="2023-02-22" version="1">MLTIPPDDIDDVKTDDEKNKDVSNKDETDGNVNEEELDPERKSAEEVGINTTLIANRFFAFAKQAQEYAKSATEHATEYAQKASAQASVLAEKASKLSESVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV35</accession>
    <name>A0A914XV35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphonate C-P lyase system protein PhnG</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XV35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1180.t1">
        <property type="protein sequence ID" value="PSU_v2.g1180.t1"/>
        <property type="gene ID" value="PSU_v2.g1180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019634">
        <property type="term" value="P:organic phosphonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015716">
        <property type="term" value="P:organic phosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009609">
        <property type="entry name" value="Phosphonate_metab_PhnG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03293">
        <property type="entry name" value="PhnG_redo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06754">
        <property type="entry name" value="PhnG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1180.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11494" checksum="26AFA9F5F8087101" modified="2023-02-22" version="1">MVRGRIGGGGAPFNLGETTVTRATVRVASGASSEGSVGHSYALGRDHEKARLAAIADALWQAPQSRAAVERDLLQKIAQRLDVRSTQRRREAAATKVDFFTMVRGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVE5</accession>
    <name>A0A914XVE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11201.t1">
        <property type="protein sequence ID" value="PSU_v2.g11201.t1"/>
        <property type="gene ID" value="PSU_v2.g11201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052129">
        <property type="entry name" value="Spermadhesin-Link_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46908">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46908:SF4">
        <property type="entry name" value="TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037272241" evidence="3">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="42"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11201.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16872" checksum="32EC4C9B56359E62" modified="2023-02-22" version="1">MLAKVIWCYMMFLVTISNGLVLKDTSKFFGPEKTNSEIYEICTSATATNDSTGTFQSPGFPSEYIQHANCYFYINATYGSNIQINVNYLNTFNGTTYGYLQISNSSMSVAKLYGRLGSVDYNYSVGNYAIIHFYLYGNGYYGSFRLTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVU5</accession>
    <name>A0A914XVU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11095.t1">
        <property type="protein sequence ID" value="PSU_v2.g11095.t1"/>
        <property type="gene ID" value="PSU_v2.g11095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11095.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11862" checksum="716B2268E71C9A76" modified="2023-02-22" version="1">MEFIQELLDEPSARIKTHFKVTNEFISNAVAGGGKVLIHCNAGISRSCTIGIAYVMWSEKKKYFDAFQQVKNARSVCRPNDGFMRQLREYEDELFRFSMCKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWB4</accession>
    <name>A0A914XWB4_9BILA</name>
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        <submittedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10821.t1">
        <property type="protein sequence ID" value="PSU_v2.g10821.t1"/>
        <property type="gene ID" value="PSU_v2.g10821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10821.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10462" checksum="797FC378DB70B20F" modified="2023-02-22" version="1">MARLGNAMQALVQSMGKSETAIIFITDTSSEFDINKALGLYNAILKNHTKLTFILAGEKAKAENLAEFNATIFDWKNMDLEKPNNWNAFKAFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWI9</accession>
    <name>A0A914XWI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11331.t1">
        <property type="protein sequence ID" value="PSU_v2.g11331.t1"/>
        <property type="gene ID" value="PSU_v2.g11331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11331.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18178" checksum="4A88273402A5FF29" modified="2023-02-22" version="1">MKSCPSNATSLKVGLNFAFGYLQFSYELSRDVDGHVTVRIARFIRSEEFVMNQKSKTDAFRLFKNTPDLTTYPPIIPLSSFDEEKHKKLCMDARGTVPTEGVQKLIDLPQFLQNLPKPETFEVLLNRFRSKVAEPIADVLLPQDLENENLKEFMARMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWS6</accession>
    <name>A0A914XWS6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione-dependent dehydroascorbate reductase</fullName>
            <ecNumber evidence="3">1.20.4.2</ecNumber>
            <ecNumber evidence="2">1.8.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Monomethylarsonic acid reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:15969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:33409"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.20.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.2" evidence="3"/>
    <dbReference type="EC" id="1.8.5.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XWS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11671.t1">
        <property type="protein sequence ID" value="PSU_v2.g11671.t1"/>
        <property type="gene ID" value="PSU_v2.g11671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050610">
        <property type="term" value="F:methylarsonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000009">
        <property type="entry name" value="Glutathione S-transferase omega-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="9">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="10">
        <location>
            <begin position="182"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11671.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36233" checksum="6275F2C97EE45ACC" modified="2023-02-22" version="1">MAGGNCTASAALCLQVINQLASIVLNQSPLAENPINDTVKHAVMSAFHGTPHSLRRHPGNFGSAFSTFSSNPTAPLPTPMPYVAGSNIRGLDSITLHPGSYEPFKAPGAIRLYSMRFCPYAERAIIYFAKKNIPVEIINVNPDKGPNWFLAKSPLGRVIFESDVLVQYLDDIFPETSVLPRDPFARAQQKILLERLSPIIQALYQFFRSSNMMAQKNTDNAINNALRTAENLLTDNFFGGKYMGYVDIMIWPFLERLELVTMNPFTQFKYFPGMHYPKMGAYMARMQRQPEIKYAMRPLPHHKGYIDSFMKGSPNYDFPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX76</accession>
    <name>A0A914XX76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX76"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11567.t1">
        <property type="protein sequence ID" value="PSU_v2.g11567.t1"/>
        <property type="gene ID" value="PSU_v2.g11567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11567.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="17000" checksum="EFB8D6FD78B1F01D" modified="2023-02-22" version="1">MKTMFWRRNINRDHLNHADRRYCQYLDDVFRPVVVRNIDKTLEKIFHAFMRMKCIPVGYYLNDRRMFYNDNVVNQNSNRTDVEDCQILVIAAITAGFGHRFTLENYMPPYADDEESRLKIQNMLLQYNKSRSSFKIVFSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXN9</accession>
    <name>A0A914XXN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXN9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11974.t1">
        <property type="protein sequence ID" value="PSU_v2.g11974.t1"/>
        <property type="gene ID" value="PSU_v2.g11974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11974.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15774" checksum="9B1187DD09589C01" modified="2023-02-22" version="1">MKKQEEDKAAEEAKKLKSVKKHESDAKAKAEEEAEKKKQAEKDAKNVAEAEKERLADIEAKKKADIEADKEKERLQKTKLEEAQKLEREKKEKYEAEAKAEQEAEKAAKDKKDAQAKALAEMEAIEAAKKKHKKLQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYJ9</accession>
    <name>A0A914XYJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XYJ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10768.t1">
        <property type="protein sequence ID" value="PSU_v2.g10768.t1"/>
        <property type="gene ID" value="PSU_v2.g10768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="124"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10768.t1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44641" checksum="F631EA3E2640159C" modified="2023-02-22" version="1">MQPRQRRKVPEGELCAVCSDRATGYHYGTPSCNGCKTFFRRTIVSGHTFVCQYNGNCDVNKNVRCACRHCRFNKCLAVGMDARAIQNDRDRIGPTKKFRMEKRNSSGEEDQISVTSSSPQQRPADDKVIENLTGIEQLCNTLRSCVMVESKNVKETLMSPCLLYRMNTLEPDPSTTFRNLYPASMEDIKMWNIRELRLGLEWVKTFEEFVKLSESDQMALVRNFAFTFNILNRVYYSGDYGPDKIVYPSGAYILRQAQDSVKIPGCRSIYHRQMDEIMIPFRKLDVSIHEFAAFKAVLLFNPDACELSAEAKPDVQRERTKYLSALFYYISTKYGLHHGVQKYGQLLMMAPSIQNIIDQNDENMQVMEVFEHIWRIDSFVKELCMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ23</accession>
    <name>A0A914XZ23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ23"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10927.t1">
        <property type="protein sequence ID" value="PSU_v2.g10927.t1"/>
        <property type="gene ID" value="PSU_v2.g10927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10927.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15967" checksum="9E833CC63A7C4EB4" modified="2023-02-22" version="1">MHMEQMHMNMMPQISLPMFLALFKNNYTLNGYGIDGLCKIMRNPQESAVEGVAGVYFWATNEGNNGIPINILDNNYDNSMAQLNRTSFNLSNPIDRDGTAASRGWMWLSCGMALGWLQSTDSSKNIFNRAVPLEFVTVSNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ60</accession>
    <name>A0A914XZ60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12501.t1">
        <property type="protein sequence ID" value="PSU_v2.g12501.t1"/>
        <property type="gene ID" value="PSU_v2.g12501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12501.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12158" checksum="CA575F0FD5656AD3" modified="2023-02-22" version="1">MKMHYPEVKRRILDDEILLLCVQISVMFSKLNEIATEAERNLTVLGVQFDAEHRIVNMSPEARQYLQACKTPILNVYFAFGAEYSEYITDDMDVLPKLSVAHQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ84</accession>
    <name>A0A914XZ84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZ84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12270.t1">
        <property type="protein sequence ID" value="PSU_v2.g12270.t1"/>
        <property type="gene ID" value="PSU_v2.g12270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12270.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19486" checksum="0B40B01422C93350" modified="2023-02-22" version="1">MKVVICFTFVSVSRKNVNVALVQSFLFKCIEVFGEYFKDVEEESVRDNFVIIYELLDEMMDFGYPQTTDGKILREYITQEGNKLEAPRPPMAVTNAVSWRGEGIKYRKNEVFLDVIESVHLLASANGTVLQSEIVGSVKMRVYLSGMPELRLGLNDKVQFEASGRGKTNKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0I7</accession>
    <name>A0A914Y0I7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y0I7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12724.t1">
        <property type="protein sequence ID" value="PSU_v2.g12724.t1"/>
        <property type="gene ID" value="PSU_v2.g12724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12724.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15528" checksum="24C0EEABE2076A5D" modified="2023-02-22" version="1">MIMLQTALNCLTIKGTLIINNCCTVAKITAMFGIIGLGIYALIDDVDKATISYKNSFSNTTGDPGAIARAFYSALFAYQGWNYLNFIVEEVKNPVKTLPRAVLLSSFAIIFVYLLVNMAFYTGLSPAKLAGSKAATIVCLFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y121</accession>
    <name>A0A914Y121_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y121"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11536.t1">
        <property type="protein sequence ID" value="PSU_v2.g11536.t1"/>
        <property type="gene ID" value="PSU_v2.g11536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11536.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11811" checksum="36B9E25BBF8B1E9D" modified="2023-02-22" version="1">MSETLAEQSCFSKRQCGTNGNKNSAPISAPVIRYGYVGQSTVTVVQSIHNGKIVHQTLQIGKDSCAYPSSLDIHTLQDTKITVVQHRDNRANKEDDGAPHCKRYRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1B6</accession>
    <name>A0A914Y1B6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Solute carrier family 12 member 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1B6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13997.t1">
        <property type="protein sequence ID" value="PSU_v2.g13997.t1"/>
        <property type="gene ID" value="PSU_v2.g13997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="103"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13997.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35552" checksum="BA5C0F1E8692C689" modified="2023-02-22" version="1">MISRSLGPEFGGSIGVLFFVANVLVSIVILCLCLLGSSIFAKTAVIGLFVIALSYSSFLVTIFVKRATDIEIPNDNTYYYMQLSNESDPFSEKVLNYSETKTARYTSFNFKSFSENMFTNYTYDYTTGKSTDFAFMFSIIFSGVTGLMAGANVSGELARPHISIPRGTLQAVFITFLVYVLTSFLLCLTCSRELLQNNYLVMVAIDIVPSLIFVGVFAATFFSSMSNLTGASRVLQRLAQDKLFGVLLAPATFETRTGNPIVSVIISWICVVLVLMIGAMNRIAKITSIFFLLSYMGVNIACLALELTSAPNFRPNFKYFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3I1</accession>
    <name>A0A914Y3I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3I1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14005.t1">
        <property type="protein sequence ID" value="PSU_v2.g14005.t1"/>
        <property type="gene ID" value="PSU_v2.g14005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000123">
        <property type="entry name" value="Cyclin-Y-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012399">
        <property type="entry name" value="Cyclin_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028934">
        <property type="entry name" value="Cyclin_CG14939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="177"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14005.t1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39984" checksum="C7B02083CB48C28D" modified="2023-02-22" version="1">MGNKSCCFRRRGEPTKKVTKQFVPIPAPPQQNGRKASVNFLPHISERELPDELDPDPSTQPSVRPTFMERSRSEMKLKDNRRSFYVLDINKLNESSNLKKSNSCSTIFLDDSTISQPNLKNTIKCISLAIFYHIANRKNREQERLMEIFEERLHPISREPIPIENLSHDPEHRQIYRFIRTLFVSAQLTAECAIITLVYIERLLTYAEIDLCPSNWRRIVLGAIMLASKVWDDQAVWNVDYCQILHYTTVDDMNELERQFLECLEFNINVPSSVYAKYYYELRMLAIANDLQLPIHPLYKERAEKLEALSKIYEERVLPTSGHMKRSHSADQLQRNARVIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y482</accession>
    <name>A0A914Y482_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y482"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12546.t1">
        <property type="protein sequence ID" value="PSU_v2.g12546.t1"/>
        <property type="gene ID" value="PSU_v2.g12546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038161145" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12546.t1"/>
        </source>
    </evidence>
    <sequence length="574" mass="64892" checksum="6738994C18915312" modified="2023-02-22" version="1">MIIFSTILLLIGFVIFSAAGNPRVKTPVGTIEGFQHENKDGSKSHIYLGIRYARAPVGELRFEKPMPYPEVKSIMEAKAFGPACYPVHREKMAASNYSEDCLFLNLIRPAAKPKNPSGYPILVFIYGGGFVTGDTERYGYKSLSEHFAAHGIITVTIQYRVGPLGFFSTGDNVLPGNIGLWDQMYALHFLQQILPNFGGNPQEMTIWGHSAGAASVHALSISPHSEFYFKRAIQSSASLFAEWAMNENVVDNSLKLAKHSNCFDKNSEKVHDCMKTKTIDEILDAADKMGAYNTHVREFTFNPRLDGQFLSQTLESLMKSSTNIPTLFGLTDKEWAMIANTPQHPLRNPNGIDDEDKKHFGSRELQRYIGEFIVPHEETGRSGGSLRTALYEYFVDRSAPLKEEGNEEWYLNRAVDVMGDLMFVVPIIQQIEVRTALNQESYLFYQKYYNNATVGLNALVHGAVHGNENYYIFDQEFNGFEYSENDKIFQKNLLEGFRSFILTGVPKSSEIQWPTTGADSGRHIVLNPAPKVEESFEKERMDFWLRELPTKVGINILKKTRLPHAELHQKHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4T1</accession>
    <name>A0A914Y4T1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4T1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14447.t1">
        <property type="protein sequence ID" value="PSU_v2.g14447.t1"/>
        <property type="gene ID" value="PSU_v2.g14447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14447.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17159" checksum="FB3EECE88550E583" modified="2023-02-22" version="1">MNPQRENDEDTTRDAEEQKIVIEVEPVVKKSARGRKPAAGTQARLTRSRLKAAAEEVSPGRRNKPTRRTATSSSLIGNVLGEDYDDYGLSPGLGVDEDSQEAQTRPNSPQIPPPIRAWEMIQENTFKGFQGLSALIVDKWKESLKANLEQKCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5D6</accession>
    <name>A0A914Y5D6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5D6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15416.t1">
        <property type="protein sequence ID" value="PSU_v2.g15416.t1"/>
        <property type="gene ID" value="PSU_v2.g15416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15416.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20584" checksum="117D1336EEFC0BD9" modified="2023-02-22" version="1">MEQSIYQQNDDHENSDTENIPQHAIHQNEAPLSPPASPTELLSPESPIQKAQDVMVNSFYPGAEHDEPPRLPSPDPNESVEERSHEEHVERDPIQAHDQTFEPGFISSSSHNVEEHRYEEETSEQQHNGIQDDENLEPPLSNRSLESFQRHEEEVAADIQHDNDVSSYNDNVADLEEDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5R3</accession>
    <name>A0A914Y5R3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5R3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13013.t1">
        <property type="protein sequence ID" value="PSU_v2.g13013.t1"/>
        <property type="gene ID" value="PSU_v2.g13013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13013.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20154" checksum="A88575860612C9A8" modified="2023-02-22" version="1">MVHLQRPDGTITDSAAELMDVTARFYNDLYSSEAGAHTYQRDPNIPINRITADELIAAGKRMKANTAPGADNIPSKAVKSTISTFAGRLADAFYGLLEEDNMPPELLHAKTILLYKKGNRLDIGNYRPISLLPVLYKILTRVIADRVQTSAENTHALPPEQAGFRRTYSTRIQQNATVSCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5Z3</accession>
    <name>A0A914Y5Z3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5Z3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14186.t1">
        <property type="protein sequence ID" value="PSU_v2.g14186.t1"/>
        <property type="gene ID" value="PSU_v2.g14186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14186.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34549" checksum="4E1A4D4B34E80A30" modified="2023-02-22" version="1">MQMREEECKYILDEIRKISVDKNSKPIADIVIMDCGLLNKNKNKEEGELTTSSSSNEVVIEKVTKRRRSSSVEILENENDIKKRRRLAAANMPKFCERENPLYRKSSEHPRNELFPERHDQQSDFGRRRRFREDDSPPRNQNHSKNKAEKRVKGRGTARYEPYSSSNIPTPSYWKAEKQRIIPMKDAKDLILRKQEETKALFSEMTDQTERKNLFPIYHPEHVEARKMLQKEAETAEKAAEQERYFGYENSYDNLGSGSSTTSSRFHHSNQETSTTPRYDLPYGFYPTPINFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y815</accession>
    <name>A0A914Y815_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y815"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14890.t1">
        <property type="protein sequence ID" value="PSU_v2.g14890.t1"/>
        <property type="gene ID" value="PSU_v2.g14890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="58"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="150"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14890.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19930" checksum="A47F1ED7BE657A3F" modified="2023-02-22" version="1">MDVIQVLGDFSKRRQDGKSRKDYLSILQKDLCAYYGYNEFLMEKFMQLFPNFSELIEFLDANEQPRPVTIRTNPLKTRRGELARSLINRGMNVDPAAKWTKVGLVVYDSQVPVGATPEYLAGHYIIQGLCSLLPVMSLAPQPNERVLDMCSAPGGKTTHIASLMRNTGVLFANDANVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8B0</accession>
    <name>A0A914Y8B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8B0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1499.t1">
        <property type="protein sequence ID" value="PSU_v2.g1499.t1"/>
        <property type="gene ID" value="PSU_v2.g1499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="55"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1499.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39356" checksum="65D3EBCFC359E0C3" modified="2023-02-22" version="1">MAAITLGIQYLKYGNAMMAHPPHLRPKVLDKWKHNFLKISDIKIHYVEAGDPKNPLMLCVHGFPEFWYSYRYQLDYFKNKYHVVAIDMRGYGESDKPVGVENYGIDLLVKDLDEIITGLGKEKAFVVAHDWGAVVAWVLAMLKPQKVEKLVILNVPHPRAFQKLLMTTLSQFRRSWYMFFFVCPYLPEISLRSFDMKALISMFRGTKTGLIHRENFTDEDVEAWKYIFSMPHAMTGPVNYYRAAMRRIGTPPKDVKTVKPPTLIIWGEKDAALDVRAAENSLTYCTQAQLKRIPDASHWVQQDKPHLVNEYIDKFLAEDNNSTNDNNADHQNTLPSQKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAV4</accession>
    <name>A0A914YAV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15897.t1">
        <property type="protein sequence ID" value="PSU_v2.g15897.t1"/>
        <property type="gene ID" value="PSU_v2.g15897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15897.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10273" checksum="68DB22AF4F16C9BF" modified="2023-02-22" version="1">MASDGLWDVLNNDDVAHIVRSALSNNDADDFSKYTLIAQELVAAARGEQVGQFKWKLSNGAMASTDDITVFVIPLKFSVNLPKGDEDDDEELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBE8</accession>
    <name>A0A914YBE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBE8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14814.t1">
        <property type="protein sequence ID" value="PSU_v2.g14814.t1"/>
        <property type="gene ID" value="PSU_v2.g14814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF53">
        <property type="entry name" value="GH23275P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14814.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41429" checksum="32AEF11EDC39D490" modified="2023-02-22" version="1">MAGGSDESSGLVLLTGNSHPQLSELVSTRLGIRLGDAIVYNKTNRETNVDVRQSVRGKHVFIIQSASKDVNNNIMELLIMIYACKTSSSKSITVVMPYLPYSKQCRMLRRSAITMKLVADMICRAGASRLVSLDLYKKEIQGFFSIPVDNLRASPFLLQYIRENIPDYKNAVIVAKSPGVMHKASSYADRLRLNIAVIHGEEQKDVEETLKTDGRQSPPPEPTGNKKEEESPEHKASTAGPSATTYELYPMLMAKEKPPLTVVGDVGGRIAIIVDDIIDEAQSFISAADVLKKRGAYKIYVIATHGLLSGDAPALLEDSCIDQVIVTNTVPHDMQKMRCHKIKTVDISVIICEAIRRIYNKESMGFLFKDIALDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBH0</accession>
    <name>A0A914YBH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1611.t1">
        <property type="protein sequence ID" value="PSU_v2.g1611.t1"/>
        <property type="gene ID" value="PSU_v2.g1611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF3">
        <property type="entry name" value="STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="196"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="729"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="764"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1611.t1"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130012" checksum="B2DA9D5178263C24" modified="2023-02-22" version="1">MHSSPRQMQPKEEVDKDLLKAAETIADQLLAGLPGSPPAISPISPPKLPSPPPVEVHAKIEITAGGDIPTEAEVSDLELDGQQTAEKEEVKPAAMSPSVVVKEATPPPSDDHKDDDTQKDVTVIDTEEDYSKTTKIRKREETYSLLVKVAESLGQSLAAKIIIDAMHDAARHLATTAATSSSEESESEGGVIKISPSLTLAPTFEISKETYNIHSGENVTIHTRIEGAPCSKVEWFKEGMLVEENDQISVITTEGHTQLVMKKVGKYNSGIYTAVATNPYGTATYQCTIHVTDSDGEIAGPYVTEIKKAEAEPTQTISNNVEIHKKHDQFDQEVIVEYLPFENIEERAVAKTTKKRSRDEQKKKKRLSMESLKSNGSEASDRMETIDEPSPQIGDEKAVEIVSKTEGAAEAVQETDETTLREEEIKVKDEPQNVTPTDAAALPEQPKQPPPEEKQISAIEETTTPISEQQKVSEIAPKEEEGQQNEIPVIQEQQTPESQEQETHIVVKSSGTEQHTEVDVTEKIEELTPQGVVKREEDETTAFKADTEQQNEKPKEVVLSFDKSVGKEQTITIENVETIEIEKDIIEPKMDENVKIEEDIVGMDKIKMNEEIEKVEESGNLKIDESMKTENMDDNQQPKSDKEIIAAKPNEEKVTEVAINEERKTETAPTIEEQIKTAENVTEEVKQTGVTKQVEKVEEAKIPTMEEFMSDTDIAEFVNKLVEAITSEATTESEQQLKELLAEQSDLTQAEEPRQTTPSPTKAILTLEEQLKQLQKDLDESGLEIHEDRNHELNIEKEFEKEVEREEALAEARKRYSREPSEDTILEEPEIEETFEVISKQDVKLSKDGIKGQASDTLPQSPTEFREICIPEITLTNESGEPVVEMTTSITDIELISDIPEAESPSPEEHPEISAPEVNIEITKEDATFTYHLRIVQPQLLIISAELSGTLLSNQRIISVNEDITKIPDQSGIEVSVLTPALTKENVIYKWILKKEGGATESRDTWILNRLIATKFFFVIFLKEEPTSPTSPEATAIANINVAYSGPSHPIVEISMLEPSKLLTEVLSEIPKSQSTTTSLTSQTQTYVTAHEGLDYSEDPIHEPLTLDERSQSTITETSTSGINQAPSFRQEIQNATFVAGQSAQLKCIVAGNPSPQVQWFVDGDEIQSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBN7</accession>
    <name>A0A914YBN7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17615.t1">
        <property type="protein sequence ID" value="PSU_v2.g17615.t1"/>
        <property type="gene ID" value="PSU_v2.g17615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.90:FF:000001">
        <property type="entry name" value="Formate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000005">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.90">
        <property type="entry name" value="ADC-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF14">
        <property type="entry name" value="FORMATE DEHYDROGENASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="10">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="9">
        <location>
            <begin position="226"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17615.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="38036" checksum="3AC90B03BFA4CF48" modified="2023-02-22" version="1">MKETVAVRERDLGTPASTQTEMVNLTIDGKLIEVPVGTSVMHAAALAGINIPKLCATDSLEAFGSCRLCLVDIEGRRGHPASCTTLVEEGMVVQTENDTLHKLRRNVMELYISDHPLDCLTCPANGNCELQDMAGVVGLRSVRYGFDGANHLDDTTDNSNPTLPMTPANALSAIAACAPRGFESRVTAGQNDGFLGSDCVSCGACVQACPTSSLMEKSVIDLGQPEHAVITTCAYCGVGCGFKAEMKGDKVIRMTPWKDGKANRGHACVKGRFAWGYATHQDRILSPMIRKSITDPWQEVSWDEAINYAASEFRRIQDQHGRDAVGGITSSRLHQRRNLSGAKAGSRCLWYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBN8</accession>
    <name>A0A914YBN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allorecognition 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBN8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16698.t1">
        <property type="protein sequence ID" value="PSU_v2.g16698.t1"/>
        <property type="gene ID" value="PSU_v2.g16698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16698.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13141" checksum="8F77D8D2364B0A21" modified="2023-02-22" version="1">MTIACQPNTSSLSKAEPILQRSETFFNVELKVNESSLNLLKQSPNGFIPSKAFNVLEIPGLSLQLLFSARSHPGEGQKFVVGLRVNNTSTSKTTTLPINMDYNVTFETANFSKHYQTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBP7</accession>
    <name>A0A914YBP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14907.t1">
        <property type="protein sequence ID" value="PSU_v2.g14907.t1"/>
        <property type="gene ID" value="PSU_v2.g14907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14907.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11283" checksum="8589B5E68F281F08" modified="2023-02-22" version="1">MPSDVPEQRRDNFDDQTIPLYSEKAANIPDKPYIGSAAKQGVEDENRRVKMVPRRSTAEYNSGGGGTRNGSITTSNIGRRIKESFNTRKRYTFFTLYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC26</accession>
    <name>A0A914YC26_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LpxC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YC26"/>
    <dbReference type="SMR" id="A0A914YC26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17763.t1">
        <property type="protein sequence ID" value="PSU_v2.g17763.t1"/>
        <property type="gene ID" value="PSU_v2.g17763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001289">
        <property type="term" value="P:lipid X metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1700.10:FF:000001">
        <property type="entry name" value="UDP-3-O-acyl-N-acetylglucosamine deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.20:FF:000001">
        <property type="entry name" value="UDP-3-O-acyl-N-acetylglucosamine deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="entry name" value="lpxc deacetylase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="entry name" value="lpxc deacetylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="UDP-3-O-ACYL-N-ACETYLGLUCOSAMINE DEACETYLASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694:SF1">
        <property type="entry name" value="UDP-3-O-ACYL-N-ACETYLGLUCOSAMINE DEACETYLASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17763.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33956" checksum="CA439A00813463AB" modified="2023-02-22" version="1">MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC74</accession>
    <name>A0A914YC74_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC74"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15076.t1">
        <property type="protein sequence ID" value="PSU_v2.g15076.t1"/>
        <property type="gene ID" value="PSU_v2.g15076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15076.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17303" checksum="291B035D7C27C661" modified="2023-02-22" version="1">MPQRRANIKLITEKSATRRCYLPGRDSPGLSSPEASSCGLESPADTTGSISDSFIIPSESDDSRIRNGDYGHGAVYSLDTFQERNTSATNDISSIETDAQSNKKFQLHRIEEESEHFDDQNGSRIHQNSTVSTHSQGFYGGRIPRSISQQVIYLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD14</accession>
    <name>A0A914YD14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18118.t1">
        <property type="protein sequence ID" value="PSU_v2.g18118.t1"/>
        <property type="gene ID" value="PSU_v2.g18118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18118.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16976" checksum="47410E9379C06DE7" modified="2023-02-22" version="1">MVPKNECLEILPKNFARSYLLKLLTNYEIFMSPKGIPKSKRIEFKRIWKYFYPDRTDGKAQMKKWSLKLRDQKRRLVYKEIQTTHTFGITDSGNEFYFEKLRPEICYTRISCCAENVLPANPVGNCGIYVPQKHFIFKKVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD32</accession>
    <name>A0A914YD32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD32"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17345.t1">
        <property type="protein sequence ID" value="PSU_v2.g17345.t1"/>
        <property type="gene ID" value="PSU_v2.g17345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052807">
        <property type="entry name" value="Mito_transl_resp_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048422">
        <property type="entry name" value="NOA1/YqeH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406:SF1">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21516">
        <property type="entry name" value="YqeH-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NOA1/YqeH-like C-terminal" evidence="2">
        <location>
            <begin position="258"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17345.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45483" checksum="B50B8EB9D78DECDA" modified="2023-02-22" version="1">MHTTLVSAKTGYGIEDLITNIYIRWMNTKGDLRSDIYLVGCTNAGKSTLFNSFLQSDLCKVRALDLVERVTTSVWPGTTLSLLKFPLMNPSTHRLELRRRRLISLQAWAKKEQSAKEMLYSQTKDLQFLTLSGVVDNTFKENLDRSNPTSNRVKNSLISNEIDVLDHDGTDEEQKIRHGVHLSDIEFTHGHWCFDTPGTVSREQVLDLYTLDELITLVPRKLIIPRFTILRPGESLLFGGTARLDFLSTVSQENPVYLAVYCSDRLPLHVMKSEEVEEFLEKFNGTNVVGVPFGDKERLDVFPALEGKELHLEKTRMLKAISDIVLSSIGWATVYSVAEKVSFKALTPEGRGITTRPPLLPFAIEYKGSRIPGTSFYKVKPMMMEKDEPEKRRKFHKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDJ2</accession>
    <name>A0A914YDJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDJ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17501.t1">
        <property type="protein sequence ID" value="PSU_v2.g17501.t1"/>
        <property type="gene ID" value="PSU_v2.g17501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17501.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35183" checksum="231157016CE9042F" modified="2023-02-22" version="1">MPTNNSVNLPLRDGIPRRHGGPGHAPKANGTTMGRRLPNLSMLYGRGPTGSAIDRRRPSAESQQPLNSGSMDSNDESGPSQSLLNHAYRAPMTSAQRFIFVNRNMPTESDDEDLYERRKRIDLEERLEEAERMNMPIQKPLMLARNQAFALAGVGSSNHSYHHAYEEPYERTYRPVPEGQSVRLPYSSRPLMHPVSLSAEERRRALTDRLVGDALQLGRYMDDTVVGVARRELAEAYELDERDLETAAYSLADPTYMPHVGGLHPDEINDINQYSQRSLLRPANSSNVQGSNGNPGGNMTANTSGTADDDLLLVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDL4</accession>
    <name>A0A914YDL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17520.t1">
        <property type="protein sequence ID" value="PSU_v2.g17520.t1"/>
        <property type="gene ID" value="PSU_v2.g17520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17520.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26207" checksum="E1EAAA6CFD1E38A4" modified="2023-02-22" version="1">MDDPGPTASDIVHFKASQQLLNPNEEPPPKRSKTNPVQDLARKHIRIAKKIDLNVDDIILRLTADFTPPIKAAVAGQTIEIVKALFVQTGYDTKRFLDIFFKEGDCELINDADESLRYLMTKLVLIIRSKGRSSMKFADVSICRRDDDTNNLCLVFGHHDLPKFKFQMIDIIQTLPTKIHGSESFELLKEKAKITTRAQRDTKLKEKKLNAKKSATKKLKMMMRIKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE01</accession>
    <name>A0A914YE01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16993.t2">
        <property type="protein sequence ID" value="PSU_v2.g16993.t2"/>
        <property type="gene ID" value="PSU_v2.g16993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16993.t2"/>
        </source>
    </evidence>
    <sequence length="381" mass="39733" checksum="258FE2DD946242E9" modified="2023-02-22" version="1">MSYNGPPPPYSEATAAVPKPNKGIIPGHIMQTPLGPIEPHVESMKPASGEFVNPYASPKQRPSVPTNASYSSDTKVPYSEASQLESGPYPQGTLRYSSNIGSGAIPDSYQGPPNSNIGNGAPPPRYQGMPSPRMPMPSYEPVGTGVTRGGIYPSVGYAQPQPPYPTDTFERGMNQPGSQMPRPNPSSYNRGSSPPLTGRIDQMSINGPPNNYPPGRRSYSPYSSNSGYPPNVGGGASYQSPPNSMAGNRAPYQNSPSPIIGGGVPHGYSSPPMGRGTSPGYSSPTIGGGTRRYSPPRGAGYSSSGPYPTPYNTPISSNFPPSGPLIGSAMIGGYGSGGGVGGYGSGSYTSIQSSHGGYCSQYPSSNYCHKKPHHSHHHHHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YER2</accession>
    <name>A0A914YER2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YER2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17950.t1">
        <property type="protein sequence ID" value="PSU_v2.g17950.t1"/>
        <property type="gene ID" value="PSU_v2.g17950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17950.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15734" checksum="9FE04BEFA5712F42" modified="2023-02-22" version="1">MTKSGTVEELKLIGVYDLTTIGSASVVPVEDIIAAVPLAKSIEIAASKITPTTFQSLISFDHKAKLVNFVLRNITPSDHYNDQLFVDFFLKNSDTSCNIRLDFELLQETSVGACHYNYFLKEMGEQYTARISWALLFILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF29</accession>
    <name>A0A914YF29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF29"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17362.t1">
        <property type="protein sequence ID" value="PSU_v2.g17362.t1"/>
        <property type="gene ID" value="PSU_v2.g17362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17362.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18254" checksum="F71D3A9789580EB2" modified="2023-02-22" version="1">MISYDITRKCQQPRWRSVSPGFRIPLTRKDIVADNKREQILYRKKPPNFRKVPAFTIQTEQQNTRPFTPAKTKFCHRSQSVTPEDERFIRIYEDRRLPIRLIDTSGTGMSRTIEWQLDPNRLSPINARELLKQFSLGLPIEKQVNKNFINNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI92</accession>
    <name>A0A914YI92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI92"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17038.t1">
        <property type="protein sequence ID" value="PSU_v2.g17038.t1"/>
        <property type="gene ID" value="PSU_v2.g17038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17038.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14739" checksum="A111A4C21EBB6A45" modified="2023-02-22" version="1">MYFHRRSGVKVLDHNREQFHREERIIPAIQKILPRTVVVIAFGAGHFSSALYRQETFERYGVRHLFNQSDEALGGEDLCYRLCEYVANHKDLDEAAKASLKLPRLKKFLRNTMDQAKIDLSGFTPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ28</accession>
    <name>A0A914YJ28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJ28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19512.t1">
        <property type="protein sequence ID" value="PSU_v2.g19512.t1"/>
        <property type="gene ID" value="PSU_v2.g19512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19512.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16696" checksum="875209AF14D23637" modified="2023-02-22" version="1">MILLRGGISEETKWITASIEELPIMKVEQLQPGIFYQFMITAVGPNGRIGKGVSSDWLQAPSIGSTGIQPNTQLQIKSQFNSDDGISALVSWPSIIPLPTVPPSLVSPSTFRPSSVGTTSPLTGIKVIPSLTSCHFQVFIENGTTFNTDTFEKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJI2</accession>
    <name>A0A914YJI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19018.t1">
        <property type="protein sequence ID" value="PSU_v2.g19018.t1"/>
        <property type="gene ID" value="PSU_v2.g19018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="1">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19018.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="8025" checksum="6F6A7C94F7AFAA6C" modified="2023-02-22" version="1">MGRFYKILEPGVAFLFPCIDNIQYIHTLKEMTIEIPQQEAITLDNVQLDLDAVLYVRVVDPYKVSFSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK98</accession>
    <name>A0A914YK98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK98"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19295.t1">
        <property type="protein sequence ID" value="PSU_v2.g19295.t1"/>
        <property type="gene ID" value="PSU_v2.g19295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19295.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22450" checksum="10E8DC970A64E8F9" modified="2023-02-22" version="1">MAAEKGDLIAAREFERREKLSVKDVLHESFLNLTYKAMMEKNNPLNYEQFGEAVKEAAAKGSITAQQHLNIWKYLNEAMEAFKKKDSTGLVAALSKAIHLDHQIVEIPDMFHSIIEERFKTHPDDLDTGTCRVKIYSRNSQMPIIVDKYLKIYPQDEYLIEMFIAGCIVFKKYNAAKEVVMIALQVPFIIHYFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKC3</accession>
    <name>A0A914YKC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2079.t1">
        <property type="protein sequence ID" value="PSU_v2.g2079.t1"/>
        <property type="gene ID" value="PSU_v2.g2079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="116"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2079.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37237" checksum="A49CCB8CB5AEEE1B" modified="2023-02-22" version="1">MVQKSASHTSHSGKSSENQIFRSRKSDSQISHSGMSADSPVFHPRKSESQISHSGDDIRHLAALLREKRNLLSASPSVYPQIQRLVDLEIWRIRQKLFQDDFNIDLQLPLPDGEKSTLTEKVFLPCKKYPEVNFVGRIIGPRGQTAKQIETATGCKVMIRGKGSMREGDRSPRARTHIEHLEEDLHVLLHCDDTPNRARVRINKAIDLINKISIPSDTGPDDLKRKQLIELAILNGTYRDKSSAESSPSFAHTDATSSGSRERSSPENSPIFTKTDTKLRSTYRERISPETSPSFANTDATTWIWNQLGINTPSALGDSPCSRTVNFFNFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL22</accession>
    <name>A0A914YL22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IMD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18020.t1">
        <property type="protein sequence ID" value="PSU_v2.g18020.t1"/>
        <property type="gene ID" value="PSU_v2.g18020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF4">
        <property type="entry name" value="FI21477P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="2">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18020.t1"/>
        </source>
    </evidence>
    <sequence length="530" mass="58113" checksum="653B38F57EA5A87A" modified="2023-02-22" version="1">MAVEVEAPAFPSLFNSVTSDLKNSQQNWESVTKTAGKLSSQLITTATALSNFIDQIQIVGDSANNIKGASRDIGASLTRFCMRQKSIENHIRSLANALTSQFCETMDKKSDEWKKRVSDIERRRGKCFKKSKQKKFFSQADLVGEQREGCLELLFEQRNQFAFFVNAILPILDIEINLLDEGEHVKQVRDSMDQIVNGTDPQQLVFNSMEDFCLNSDRRIISPAQSIISSVASGGGLDRTISPSIDSFYSTSRNSTISGATYGHYHQRQYVPVSTIFQNSSPTITMSRPPLPRQPGYHTNESCSSTRGSSQTEVNVPVTLSLSSADTTQSSRRQRPLSFSGGDINGYNDKTLKMITTPGERSSASLIAETLQQIDQLGVELDSYCNNLTHPQDSSSGVGSSVVSSIDQNGSSNYIDSPIMNNAGTTNSNTPIATPPTYRNYPSVVPYPPPAQTSSSSSTVRSRPPPPERRNSTIQTASSFAPSVADLRTINGDYGTIQFREGPPRYPGAPIMGYKHHPPTPSNFQAHSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLD0</accession>
    <name>A0A914YLD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TAFII55 protein conserved region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLD0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21150.t1">
        <property type="protein sequence ID" value="PSU_v2.g21150.t1"/>
        <property type="gene ID" value="PSU_v2.g21150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="6">
        <location>
            <begin position="15"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21150.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26739" checksum="A308466FF5480D60" modified="2023-02-22" version="1">MSQRRKRIETKECDFEWHAILRVPKSKVAALEEIIDDQIYEAEEEMIAEKSPIKPGESLLGINFEKNLRHGQFRIKDDIVEFCVQDLPCIVETYKTHNNVDLFKIADVSQILICNENENSSPMETNETECLNVAPLPPTVPTLPSLPPLPSLPPLLTVPSLPTLPSVSTVPPPPLPSNEQKELASVRETRLKLNRFPHGLTPPMKNVTKCRFRKTKKTKYIDAPQIEQQLRGIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLK7</accession>
    <name>A0A914YLK7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914YLK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20246.t1">
        <property type="protein sequence ID" value="PSU_v2.g20246.t1"/>
        <property type="gene ID" value="PSU_v2.g20246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="12">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20246.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36386" checksum="93B330B2AAFF6050" modified="2023-02-22" version="1">MSVKSYSPPSPPPLTPSMVQSNNVRTQAKIQAATQVLNNVPATQTVAPQIMMSANGATASTTIANTPSELLSAFECPVCMDYMLPPYLQCPSGHLVCGNCRPKVTCCPSCRGPVPSIRNLAMERIAQTLIFPCKYAPSGCSKQFQAQEKTEHEEICEHRPYSCPCPGAACKWHGSLTEVMTHLVRQHKSITTLQGEDIVFLATDITLPGAVDWVMMQNCFNCFFMLVLEKQDKSEHQSSNNNQQMFYAVVQLIGTKKEAENFIYRLELSSRRRRLSFEGTPRSIHEGVAASITQSDCLCFDTNQAQLFSENGNLGINVTIQKAAPLEQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLM2</accession>
    <name>A0A914YLM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20261.t1">
        <property type="protein sequence ID" value="PSU_v2.g20261.t1"/>
        <property type="gene ID" value="PSU_v2.g20261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20261.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="16030" checksum="DF09FCF1C633FDAA" modified="2023-02-22" version="1">MGSYFGAIIGWRDRRASIDEGDRRARVVECVRAVEAPAGGVGHGGREPVLHGPVFAVHLPAPVRGSHAARIAFDVVAVAAVDGCCGPGRHVVDRALRAQGTLPHTGAAARTDGRGGGVHDPARQHAAEGGGVVRPVGLAWHVGARGLVVVAGPHPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLV7</accession>
    <name>A0A914YLV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1990.t1">
        <property type="protein sequence ID" value="PSU_v2.g1990.t1"/>
        <property type="gene ID" value="PSU_v2.g1990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1990.t1"/>
        </source>
    </evidence>
    <sequence length="472" mass="53981" checksum="5004D7AE115F007A" modified="2023-02-22" version="1">MSDASKLTKEQRKDICHGNSLQNVRDQKSYQELCGAAFSLELASLVATSNKNVLALHTDFSGIHYSERYQNPENILAKNFLIGKKYNNDYDFLCIPVIVYSEKSKKAVKKLGERVGHWIIAFYFRVENLLLYVDPFGSEKLEEIYPHVKTIISRAINTVGPELTDFNPRFYFEPHNNQPLGNVIDCGYICLFSAYRTITFGPKNLYDKNYNLSNFKIKIFKNFEILTARNTPPTSPLSSDIEEIDMEYIPKENERKSPKKKHSKTKKSPTKVAPKKIITITSKKGYRPKLNKVTSDSVSPTKSKKEELHIEYATVSSDSEGPSEKDKAKNVASEKMKFKNEQEIINLDSSNDEVWDVTDEEIPFKKSKIAETPTSVFNSLSLHTPKNEKRIFNNSLTPKNSFGIRRKRAGIAKNGTVIDGIETDIPMETDCEIIKDESLEANRKMLTPKRTFVSNKKVKLNQFHQKLILMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMC5</accession>
    <name>A0A914YMC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18469.t1">
        <property type="protein sequence ID" value="PSU_v2.g18469.t1"/>
        <property type="gene ID" value="PSU_v2.g18469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18469.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24258" checksum="CD06E57C23E4F5A7" modified="2023-02-22" version="1">MRTGIVYEKYFSEHRYRQIKGRYDALRLKTDLSRDEERFLTLCICRPNDNAQKFFISPYAVTRNRVVEFHDAIIFCLIGYENYESMGIYDENELFDALLLKRNEAVPNSIINPFGVGEYEGHNGSETYCYDFYSYPTKNVLGQRTCLLAVEISQEKKYIYSGPLMGKAMIMDSMAFCYSFVNDSILYGEDYCSISISLKSVKLQCCCAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMS6</accession>
    <name>A0A914YMS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18633.t1">
        <property type="protein sequence ID" value="PSU_v2.g18633.t1"/>
        <property type="gene ID" value="PSU_v2.g18633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF1">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18633.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="9109" checksum="FE9495FC9A61C80D" modified="2023-02-22" version="1">MEDWHNFGADYDTTLMAWYERFLAAWPEIADNYSERFKRMFTYYLNACAGAFRARDIQLWQVVFSRGVENGLRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNX5</accession>
    <name>A0A914YNX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNX5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2132.t1">
        <property type="protein sequence ID" value="PSU_v2.g2132.t1"/>
        <property type="gene ID" value="PSU_v2.g2132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2132.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22019" checksum="7A3BA5B89294A40D" modified="2023-02-22" version="1">MFSRSELGSDGLSPCPSSLSSPGDSQYGSSLNFLNDDLISQPLIDFDEAECLAVIDDFDRKNPTFDSLHHHHLQQQHQQQQHHHDYEMTTLDTEYLETEEEASPSTKYYVLKGDNTLRPVGTSISFNRTSLKTVYPVRTVISRHPPSIPSDDESKQAIPTLCRTRSKMHDLAVKNRLITDQVNILYIFHIFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP31</accession>
    <name>A0A914YP31_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PhoH-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhoH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YP31"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20735.t1">
        <property type="protein sequence ID" value="PSU_v2.g20735.t1"/>
        <property type="gene ID" value="PSU_v2.g20735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000013">
        <property type="entry name" value="PhoH family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051451">
        <property type="entry name" value="PhoH2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30473:SF1">
        <property type="entry name" value="PHOH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30473">
        <property type="entry name" value="PROTEIN PHOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH-like protein" evidence="7">
        <location>
            <begin position="98"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20735.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34592" checksum="625035E3AEB9C363" modified="2023-02-22" version="1">MKSIEQSRLHPVAGRQRAAGQPLGVEIANRGFVFRISGPNEAIIEAQKLVEALYAEAGETVFDNHAIHLRLAQANVEQIAERSYEAQDVAIKVKRGTVRGRGANQGRYLHQIATHDINFGIGPAGTGKTFLAVASAVEALNESRVQRLILVRPAVEAGEKLGFLPGDLSQKVDPYLRPLYDALYEMMGVEKVVKLLEKNVIEIAPLAYMRGRTLNDAFVILDEAQNTTIEQMKMFLTRLGYGSTAVGTGDLTQTDLPKHVKSGLRDAIDVLREVEGVSFTFFESRDVVRHPLVARIVSAYDRRDLHQIQPGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPX2</accession>
    <name>A0A914YPX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPX2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2235.t1">
        <property type="protein sequence ID" value="PSU_v2.g2235.t1"/>
        <property type="gene ID" value="PSU_v2.g2235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2235.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16571" checksum="8DAA8967BDFE9F17" modified="2023-02-22" version="1">MIESSKVIVHTTVLKEQPTQTIRSNKAAAAKNGIIKNNMNNKNKKNDQKDGIKVIGAIKNTKPKNPKHLSRKSNNKSLMLQSTQFSIRSGKQEKLKHTQSDDEIHDKRGTPELTTDKTQKSFSHRLADDEGTNSNIEELPMDKHKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQC0</accession>
    <name>A0A914YQC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQC0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3008.t1">
        <property type="protein sequence ID" value="PSU_v2.g3008.t1"/>
        <property type="gene ID" value="PSU_v2.g3008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="4">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3008.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12385" checksum="014DD9DC3DF688AB" modified="2023-02-22" version="1">MVSRVNDYYENDINDQDLAIKLLKSNSTIINSSGVKEENYVDFKEAFGTERLSEFEPSRYFEFPQELRHQLNKSQSHISMGLFANIGRAWMSVDSDLFFWRFDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQF7</accession>
    <name>A0A914YQF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2414.t1">
        <property type="protein sequence ID" value="PSU_v2.g2414.t1"/>
        <property type="gene ID" value="PSU_v2.g2414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072383">
        <property type="term" value="P:plus-end-directed vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901098">
        <property type="term" value="P:positive regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753">
        <property type="entry name" value="FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753:SF2">
        <property type="entry name" value="FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="637"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="743"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2414.t1"/>
        </source>
    </evidence>
    <sequence length="898" mass="106531" checksum="3C8352628FEC3226" modified="2023-02-22" version="1">METQKYRDESEKLIDSLKNEHSENIDNLEKEKFALQKEVSTLEERIENLSENHSKAVGDYKLLTEQFDVHKSDKDEEISRLKEQIHKIEEDALQDLTDLGEQKAKEKLDFEEQIRKLEKDILHAEEDIRGGLMRENEFKGQIEIEQLRSQIDQLNASLAWTKQEKEEGQRKITDLEQTLQMTEKQGRIKELDEEVGESGEKIRNYENQISEFKFKIKDLESQLTEINDQKDKYKTLLKQIEGENRDLQNEHSNLKKQLAVSEARISEADHRHEQRLSELRKINSERKDLELSFTDKTTELSSLNTVIKQYEHHQIGYIKEIAEEKEKSTKLEQQMTKLKAENKHTKEELQNAMGQLEKKTATNQAVINDLLDNYRSSEKDKLTAMREVEERGAEIEVLRHRLELGDKKRKDLEERITEIVKERDSLIDRLNYYERSAKKVLTFARKKALKYIIKFMQINISETHITTRAHSQEPLTRYQELDLDEDLFDSSDSGSPRRFNLKPSQSTHDIPSSKFTHLIPTKVSGSSNFDIQNSMEVTFKLLKDKIASLEEERRNLVIRLRKSKTESEEFHANFLDQKQKATDAQKIIQRLHEDKIALETRLISSRQILVAQEESLRAREQDKKSFKAKIASADMHSRDKEARLQSLQNEITSLKLEIQNLEDDKKKFKDFEISWERERRNLENAFKDTKMELENVRRDRLMLIRDKEQRPKEVQLIQSVNRVTLTHRLKDSEQQTTICQQKCSELERTIERRQQSLSKMQHDETQWKHKIDNMKRTAADYQQMEVKIESLKIELEAMTQKWKNSENDREQIRRELIECRSKLNSTSLKTNDLQMIISELNGEKKRCQDRIEILEKYERDNTSMERELRRELEQIKGEKLTMIAETEELKRQLHRVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQP7</accession>
    <name>A0A914YQP7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YQP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2345.t1">
        <property type="protein sequence ID" value="PSU_v2.g2345.t1"/>
        <property type="gene ID" value="PSU_v2.g2345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="168"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2345.t1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46502" checksum="05FF554CEBAED5E8" modified="2023-02-22" version="1">MYSASPTNQELFHLRILLNHIKGATCYEDLKRVDGNICQTFSQACLELGLIEDDKEWGRVLKEADVSLLPYQMRNLFVRLLIHCQPIAPHDLWEEFKEAMSADFALNFSKDIAIKKSYREICRLLENEDKDIKDFPTMPQDLSFDDDYDTYDPIHDEAIGIHMRSTANPEQENVIDKVIKVACDKNAQNDEGTCFYIDGPGGSGKTYIYKTLWHLLRSLGKKVSTMAFTGIAAILLPEGRTNHKTLGLPVPIYTDSNSSIKPNTKQAKNLIETDVFIWDEAPMAPKYALEIMDRLLRDLTKIEKPFGGKILLLGGDFRQLLPVRKNGTRSECVSLSIKYSNLWGLFKTFKLYRNMRADANEIEFAKYLLDIGEGKVNDENDNMEFPEEFIVETDLVQEQEMPMLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQZ5</accession>
    <name>A0A914YQZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g32.t1">
        <property type="protein sequence ID" value="PSU_v2.g32.t1"/>
        <property type="gene ID" value="PSU_v2.g32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g32.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21420" checksum="DCBC805B935B2915" modified="2023-02-22" version="1">MPPGVVGVGVTASSSSSTNSINFVTTSLPATSITSSPAPTFFPQQILHNLQPLKSNADLIDATTNPLTMATFPPNSYQYPPFIDSSLSDATPYCWQSGANEINRFGSYERYQYPQHLPTSITSINNNSISSNNERMADFEKLQSYDHFEPLGSYNQSWNTYNSYLANNDKTIHPQYFDKDFYSQQLTVSILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS54</accession>
    <name>A0A914YS54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20227.t1">
        <property type="protein sequence ID" value="PSU_v2.g20227.t1"/>
        <property type="gene ID" value="PSU_v2.g20227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20227.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11411" checksum="38D4CE15850F08FA" modified="2023-02-22" version="1">MPRRYQTWVPKPACRLPNESGSSTPVRIRDALAILNLGHDARLQHHRHAGIRWQGTRTLDGLVSVVYLVHIELGANHGVALGTLNGFQANTLANTLYPAIAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSB6</accession>
    <name>A0A914YSB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase class I/classII domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSB6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20291.t1">
        <property type="protein sequence ID" value="PSU_v2.g20291.t1"/>
        <property type="gene ID" value="PSU_v2.g20291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050881">
        <property type="entry name" value="LL-DAP_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42832">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42832:SF1">
        <property type="entry name" value="GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20291.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16989" checksum="E1323B9C80D75261" modified="2023-02-22" version="1">MSMGNPDGATPAHIVEKLVEAATRPDTHGYSVSKGIPRLRRAVTNWYERRYNVHLDPDSEAIVTIGSKEGLAHLMLATPGQGRHRSGAQPQLPDSYIWCRHCRREYPFGAHGPRRGLFRGNRKSRARVHSQAQNDDSGFSQQSDGPVCGTVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSE9</accession>
    <name>A0A914YSE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSE9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3642.t1">
        <property type="protein sequence ID" value="PSU_v2.g3642.t1"/>
        <property type="gene ID" value="PSU_v2.g3642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3642.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42103" checksum="7C2B0646EFC54095" modified="2023-02-22" version="1">MVLQFHIDQCKLTNNAEYYFYAIIGVIIFAGISILIGIGLIIWKIVKYCSLENQRYEIEKFVVACYVEKLEKISKIPIGNEKPKSKKKKKRISPSESRSASYHSHHHHRRHRRRSQRSVTESVSKIPHGSKILPLPNEKDLFASDRKKVELKPVAIQEPRKEKTGRRDPSKGSNTSVCSLKSVTQSVDDSLDWTGKGVRVSQRKPALQLYKEDQTKDEDEAYKLGMNLSTFKRKKKRQQHGSQQDDEESKKKQKTQYPLSVASGMSSYTKPMPPIATTVTATPVPPTSAPTTITVATTNSKLLRGDQTAQDEARFQRAEKELQDRVEAQQKQQQQQAKNPGGGRASVYLGNNNPYGSLSVPMGPPDVFPQNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSY1</accession>
    <name>A0A914YSY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSY1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3109.t1">
        <property type="protein sequence ID" value="PSU_v2.g3109.t1"/>
        <property type="gene ID" value="PSU_v2.g3109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3109.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14380" checksum="BAE9C8C6967325C7" modified="2023-02-22" version="1">MATSEKEYYTFHDKMEHELNKLQSTTKREIADIHPSFDFAVIADIVQSKAEKKYFVIAELKKPTVSFIPANYIRESTTFEIGQKLKIVRKCGIGLEDIQIIPNEVDDDSYFEYNWCEGVSCDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTE4</accession>
    <name>A0A914YTE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3958.t1">
        <property type="protein sequence ID" value="PSU_v2.g3958.t1"/>
        <property type="gene ID" value="PSU_v2.g3958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3958.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="34810" checksum="581F17A5B263A6A6" modified="2023-02-22" version="1">MVCQCTLNTLAYFALSYIVYRFVWALYTIVYPYLIASPPDLHKLAGGKWAVVTGSTDGIGKAYAFELAKNGFNLLLISRTQSKLDATKEEIKKEHKNVEVETISYDFSDANLNDYKKEVLPAIEKRDVGILVNNVGLSYDYPEILHKVDGGLQHLANVGIVNILPTSILTAAVLPQMVQRNNGVIVNISSSAAYAKMSLWAVYSASKAYVNHFANILRNEYAHTGITIQTICPMMVSTKMSKARVSFFAPNTTNYVRSAIRTIGVIPETTGCIQHQIQSMIFGLPELVLDLLITKNSQAVRAAALRKREKAAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTR6</accession>
    <name>A0A914YTR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Enolase-phosphatase E1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTR6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3058.t1">
        <property type="protein sequence ID" value="PSU_v2.g3058.t1"/>
        <property type="gene ID" value="PSU_v2.g3058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00044">
        <property type="entry name" value="enolase-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3058.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28228" checksum="A06A24FA0979BFBB" modified="2023-02-22" version="1">MGMFERPQYKALLLDIEGTVTSISFVKDVLFPYAYENAEQYLQTNIKSDKLKSLVDALMELSNQEAAVDDNIQKVESTEDWKAIASNVKVWIQNDRKLKPLKDLQGFMWEDAYLSGKVLGHVFPDVKYVLNDFYIVQIPVYIYSSGSVHAQKLLFSHSIDGDLTPLLSGYFDTSVGPKIDATSYKKIADQLKLQPNDILFLTDVAKEAIAASDAGMRVFLVVREGNAPLCPDIMTRFKTINCLEALVCHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTS1</accession>
    <name>A0A914YTS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pao retrotransposon peptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3062.t1">
        <property type="protein sequence ID" value="PSU_v2.g3062.t1"/>
        <property type="gene ID" value="PSU_v2.g3062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955:SF65">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955">
        <property type="entry name" value="RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3062.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42983" checksum="D94A7B137B6BE225" modified="2023-02-22" version="1">MEIIPDELKQKSFIAKVLGLEWDSKNDTLQIQLWNKSKVEKWTKRNVLKFIASAFDPLGFLSPVTVKGRAFMQELFKEGLTWDEPLPEKLLKVWQPIFSDWNGIVKIPRRLTLAKFPGAQGIEIHAFGDASQTAYCACVYLRIQTSSECVTPLIFAKTRLQPLNKNLTIPKMEVMGIWLASKISSFVAKELGLEVCQRFIWTDSQISCYWFQKHPKDVFVTNRLKEVLETRSELMFVPGKLNPADLGTRGVKFEELVKAHFWWKGPDFLRKSKEKWPKFPKHDSNLTQTATVFVAINDLHFTTVLQNVEIHREFDVSSGESWTSLKRAAALQLFPDKTADTLTVKEIQFAERALIAQEQQVCLTAKLEKDFKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTU7</accession>
    <name>A0A914YTU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTU7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20870.t1">
        <property type="protein sequence ID" value="PSU_v2.g20870.t1"/>
        <property type="gene ID" value="PSU_v2.g20870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20870.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18209" checksum="EC3C22BCBE2D692D" modified="2023-02-22" version="1">MRYVGFITRWVKQHSQIGDKCTLPGGIKANVDKEVLFAVIQQLFTAEDFIVGGVDGNQFAVSVSGVKTFAFAIQRQTGTHFTGVLDGGFQFDILAINDPNHALFTNTTDVNGVRGIISYQLTRLQRAHLFRALTIIQHQTAFHFARFGIYRRDRAVYGVTNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU72</accession>
    <name>A0A914YU72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonucleotide reductase large subunit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YU72"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3538.t1">
        <property type="protein sequence ID" value="PSU_v2.g3538.t1"/>
        <property type="gene ID" value="PSU_v2.g3538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000035">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleotide reductase large subunit" evidence="4">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3538.t1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53963" checksum="0E51439A15963596" modified="2023-02-22" version="1">MDFLELKRNTGAEENRARDLFYALWIPDLFMSRVECDEMWSLMCPTECPGLDDCWGAEFEKLYTKYEGEGNYKGQIKARNIWKSIITSQIETGTPFMLYKDACNGKSNQQHLGTIKNSNLCTEIVEYTSSDEIAVCGNASIALPRFVDANGNFDYAKLNKIAKIIVINLDKMIDSTWYPVWQAENSNKRHRPIGLGVQGLADAFQLCRLPFTSEGAKMMNKLIFETIYFAALEASCELAERYGSYSTFENSPTSKGILQCDLWKCPPSEATSFWNWKELRQKISKFGLRNSLLISLMPTATSAQILGNNESIEPYTSNVYSRRVVSGDFQVVNPHLMADLIKLNLWNDEIKNMLIAHGGSIQNIPEIPIEIKELYKTVWEISQRDIIDMAADRGPFIDQSQSLNLHLASPSYSKCTSMHFYAWKKGLKTGMYYLRSRPAVDAVQFTVDKEALKICHVPAAPPPPTTPTPTTSDTPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVC5</accession>
    <name>A0A914YVC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3615.t1">
        <property type="protein sequence ID" value="PSU_v2.g3615.t1"/>
        <property type="gene ID" value="PSU_v2.g3615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18362">
        <property type="entry name" value="BTB_POZ_KCTD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000005">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958:SF29">
        <property type="entry name" value="INSOMNIAC, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3615.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23903" checksum="3AAA8D9F57BC2418" modified="2023-02-22" version="1">MNGTNSYPPKGGGGGLPPGWIKLNVGGKVFQTHRQTLSREENSFLSRLCQEPESLPSDRDDEGAFLIDRDPEYFSSVLNYLRHGKLILNRGLTEEGLLEEAEFYNMPGLITLCKEHILNKSKPKNNIQHVYRVLQCHGDELTSVISHLSDGWQFKQLIPIGYESIQQSGEFAQEFVCVVSREYLENEKQSHQHYEGSDRAQVLQQKAMHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW61</accession>
    <name>A0A914YW61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3896.t1">
        <property type="protein sequence ID" value="PSU_v2.g3896.t1"/>
        <property type="gene ID" value="PSU_v2.g3896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3896.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17442" checksum="71ED84C4E7E9668A" modified="2023-02-22" version="1">MSFSTLRASSGSEPSPCLFEPLSVITEAAPTSKSTASSPTEHDNIDFQRFQSVSPTLNVQSSTRIKNRIGLSHRKYETLRRELAVEGIKMPSPSTIRRNENRIFDDHFQNSDKPDFYGLVNKAVSKYDFSTFENVRITIGGDGGGDGEKSSVKLFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWK1</accession>
    <name>A0A914YWK1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="4 17">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="17">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="17">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Peripheral membrane protein</topology>
            <orientation evidence="1 17">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4 17"/>
    <dbReference type="AlphaFoldDB" id="A0A914YWK1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2459.t1">
        <property type="protein sequence ID" value="PSU_v2.g2459.t1"/>
        <property type="gene ID" value="PSU_v2.g2459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="15 17" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="18">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="19">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2459.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35130" checksum="5B93A1E981329015" modified="2023-02-22" version="1">MLRVKSLSQIHRTVATATKGTNVKTFEVYRYNPDQPGSKPSMQKYDVDLDACGPMILDALIKIKNEMDPTLTFRRSCREGICGSCAMNIGGQNTLACICNIDNNTSKSTKIYPLPHMYVVKDLVPDMNLFYAQYASVQPWIQKDTPIKLGEKELHQSVAEREKLDGLYECILCACCSTSCPSYWWNADKYLGPAILLQAYRWIIDSRDDKHTERLSRMTDGFSAFKCHTILNCTKTCPKLKQTSLRCCFLFASTLLLHQHTATVPAKQQNNTNKTKHLNPAKAIGEIKKLLTGVSTKPKPVQPPLLSKQSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWK9</accession>
    <name>A0A914YWK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWK9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4493.t1">
        <property type="protein sequence ID" value="PSU_v2.g4493.t1"/>
        <property type="gene ID" value="PSU_v2.g4493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20617">
        <property type="entry name" value="CYP1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF369">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4493.t1"/>
        </source>
    </evidence>
    <sequence length="434" mass="50578" checksum="D8D46BC312B5CC2B" modified="2023-02-22" version="1">MPVVCVNDSKTIYETFVKDGETYAGRAQLTEWLEVVKHGQNGIIFSEGEPWREHRRFALRVFRDFGFGKNLMQEKILDEFVYMMDSIKADKKAGIINHSLQDHIDLAVGSVINSLLFGFRCSSNKKEDFNAQKEIIGAAMKDSGRIEALIMQSGAHKFRFLPYFRKVYYDIQKNRDKTWAYFDEHVQKRKETMDLDSDADPVDYVEAFLRQQHQLNLKGEKHHFTDTQLYGILWDLWIAGQETTSHTTAWACQYLIKNLKCQAKVHEELSKFIGSDRLITITDKPNLHYINAVVAETQRCCNLVNTNVLHRTLKDVKIHGYDIPKHTVIISHITSVLYDERYFPDPYTFKPERFLDKNGIFSWPPELMPFGLGKRACLGESLARMELFLFIANLFNQFIFKENPEKPINEERHLCGTIAPQQYTCLVERRSYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX49</accession>
    <name>A0A914YX49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX49"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5094.t1">
        <property type="protein sequence ID" value="PSU_v2.g5094.t1"/>
        <property type="gene ID" value="PSU_v2.g5094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5094.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18067" checksum="C88F148EA6E31652" modified="2023-02-22" version="1">MINSTKLNAFFPNISKTQAPLIHFSRRLFSEKQIESTSTPTTPVYEKPRYATRSNYESTIRSSRIGREADPNTGVTPTYMQRWFLIITRLYRNRSEQPNIVPTPVILRMHERMRIVYLITAIPIFFAIFYIFEYLTGKKIVRDRASGKVVTRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYR8</accession>
    <name>A0A914YYR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYR8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5252.t1">
        <property type="protein sequence ID" value="PSU_v2.g5252.t1"/>
        <property type="gene ID" value="PSU_v2.g5252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5252.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10189" checksum="609B69573C855438" modified="2023-02-22" version="1">MARGRPRTASKSDTTKDGKVTKSKAPPTPSTTSTSTITATETKKASPKGKRPATAKPGASSANKRSRPATSSHHKKGGNKNDTKQSKKDESKKQAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZL1</accession>
    <name>A0A914YZL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5537.t1">
        <property type="protein sequence ID" value="PSU_v2.g5537.t1"/>
        <property type="gene ID" value="PSU_v2.g5537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5537.t1"/>
        </source>
    </evidence>
    <sequence length="669" mass="75960" checksum="5185323F40F2315F" modified="2023-02-22" version="1">MASQFKKDIFDFGFLPILVDYLDFKNSTVRLQAAVILTYLCQDLSKNVEIIAKYGAFTHFVKHLNSTNSELASLSLSFLHTVISEFPHLHKYYDYPEFVKNIEKFIDTEPSKEILLANHKDSKIMHNGALGLRMLAILPEKPYPGVFDDAKVIEAVIKMVNNRQEKIQTTALLIVSHIINDKNVCFFTKSDIINQMPKFIKKGDARSVNLALQIIRKIVLQSKTGTSEVMDSDIFPLIIEKFSSPLNIQKEAAYLLSFFAINGNEKHISIMINKGIIEAYCNFLKKTESPKIVESILIGYYSILVTAENRRCQIFDQLEKCNALFKIEKLGKHEDQNIKKLSKEIMAFYHDKNDEQTLIVTKINALEPILILKEGNFVNSYYDISEVAKFAVENGKSSKIDDQNAIILLAQNLFSNGLTDEIAKSGILSALIEYMDSSNPDVKHGATILLAHIAYNSTKMVQLIVEEGAIPRFFKSLDSSNENVVVHSLIFFNTLVLSHPNLRNNYSELELVQNIHTLVDSKPSTLVLQYSTTLFYGLSRNKNPSISHEAIKAMLPVFSKFLQHPHYQIAGNSALTLAILTSNKENGYMIMFEEEDIQNLIELLNRQNEHVQTSTLQLISKIIDNSEHETQLFLDTGILQLLTNFFKNSDDDDIVFWGTSNHSKNYSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZY9</accession>
    <name>A0A914YZY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5664.t1">
        <property type="protein sequence ID" value="PSU_v2.g5664.t1"/>
        <property type="gene ID" value="PSU_v2.g5664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5664.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8756" checksum="44A5F8C787616B13" modified="2023-02-22" version="1">MDVCGTFKDCNSELQISVNSLELSEIDINTSIEKFLKNYWTVKPVKDAKNTYHTVGYYRRCNCGFRIPNKQKFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0Z5</accession>
    <name>A0A914Z0Z5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">protein adenylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.108</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55932"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-(5'-adenylyl)-L-tyrosyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fic family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.108" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z0Z5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6030.t1">
        <property type="protein sequence ID" value="PSU_v2.g6030.t1"/>
        <property type="gene ID" value="PSU_v2.g6030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF34">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE FICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Fido" evidence="22">
        <location>
            <begin position="320"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="402"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="434"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="18">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="19">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6030.t1"/>
        </source>
    </evidence>
    <sequence length="495" mass="56026" checksum="405F42203069DF2C" modified="2023-02-22" version="1">MTARRSSRAQETIENVRNALPKRVWLYIGVICILSSISIQFIAPFVQLLLTNSLICLNPLVNDNIKKVYDCIGTQNLNQQRSTLFKKTNSLQKITYFAEPFPVEPWVNDEEEFAETSDLRLSVIPRRPISPIPDPFTEAEAIAALQLAKKSRERGNNRKAEVIIEHAFALAPHHPDVLTEYGIFMETVRNNVIEAEGLYKKALNLNPSHSEALIRRAKTLPLVEEIDNNMFREIRKKREIFLKIPRWNSGLKRAMRESYFQHIYHTVALEGNTFTLGQTRSILESKLAVAGKSIIEHNEILGMDAALRFLNQTLAHVGSITIEDILAIHKRVLGFVDPIAAGYLRTTQVFVGSFVPTAPEFVRQELNELIEWLNDEETLRIDPVELAALAHYKLVYIHPFIDGNGRTARLLMNFILMQAGFPPVIIPVEERGKYYITLKSANDGDLRPFIRFIAKMTDDSLQSFISSASICDPKDCPENGKIGGTDSTSKVIETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z180</accession>
    <name>A0A914Z180_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasma membrane fusion protein PRM1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z180"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5652.t1">
        <property type="protein sequence ID" value="PSU_v2.g5652.t1"/>
        <property type="gene ID" value="PSU_v2.g5652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5652.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20418" checksum="B43FB6825C5884D6" modified="2023-02-22" version="1">MSVDKTIEELSQTLSQLSILVEHINGQIVGVTSRINITLDNFDNSVGGIAKDASALTGQVGDTVSQIPNSWVFYLLFITLIVVLILLSILIIINLVTKAHAIYRLCFPDAAESEANTPLPSNYSESRLLQRYDNSLQRFPKATRNDIAIPIEDARINTTSFPMDSSGINPSFHNNGFQTGRPNLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1A4</accession>
    <name>A0A914Z1A4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Strictosidine synthase conserved region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1A4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6140.t1">
        <property type="protein sequence ID" value="PSU_v2.g6140.t1"/>
        <property type="gene ID" value="PSU_v2.g6140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="4">
        <location>
            <begin position="128"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6140.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38766" checksum="A0642C3211F9E1DC" modified="2023-02-22" version="1">MAMPKKPDLLGALSSNIDLQKAEILFKGEINGPESFVWYNGALYSTIEDGFIKIINDKIVKKIKAGEIGCSSLPECGRPLGIRHYKNEKFFVADCYKGILEVDFETEKVTTILSGDTVIDGIKLNIADDLDFIDENAIIFSDASIDWDLPRFLNSMLELKGDGRIIKYNLKTKKAETLLSNLQIANGIQIHSDKQSVLICETSAARISRYYFDGPKKGIHEYFVTNLSGLPDNIRTTNNGTYYIAFAASRIPNHWSLIDFLAPFPFFRKLILQLIPDSLKFALFEATIAKYGIFVEVDKNGKYIQSWHDPSGFTNMLSQASDADDVIYVGSYSHDHLAKIYKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2S5</accession>
    <name>A0A914Z2S5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2S5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7011.t1">
        <property type="protein sequence ID" value="PSU_v2.g7011.t1"/>
        <property type="gene ID" value="PSU_v2.g7011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000001">
        <property type="entry name" value="Geranylgeranyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053378">
        <property type="entry name" value="Prenyl_diphosphate_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045485">
        <property type="entry name" value="FPPsyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007877">
        <property type="entry name" value="PRK10581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43281">
        <property type="entry name" value="FARNESYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43281:SF1">
        <property type="entry name" value="FARNESYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7011.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="25814" checksum="F06963EECEA8E28A" modified="2023-02-22" version="1">MFGVSTNTLDAPAAAVECIHAYSLIHDDLPAMDDDDLRRGLPTCHVKFGEANAILAGDALQTLAFSILSDADMPEVSDRDRISMISELASASGIAGMCGGQALDLDAEGKHVPLDALERIHRHKTGALIRAAVRLGALSAGDKGRRALPVLDKYAESIGLAFQVQDDILDVVGDTATLGKRQGADQQLGKSTYPALLGLEQARKKARDLIDDARQSLKQLAEQSLDTSALEALADYIIQRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3J0</accession>
    <name>A0A914Z3J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HIG1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g482.t1">
        <property type="protein sequence ID" value="PSU_v2.g482.t1"/>
        <property type="gene ID" value="PSU_v2.g482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF18">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g482.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16394" checksum="C7535AAC3B2BE0DF" modified="2023-02-22" version="1">MSDTNAAPSSDFMTWRVEDHSNEKPQQKARRNFSEVVPMIPSDLMGGSERSNLMNPLVRSALTNPLVPVGMVATVGCLIGMCKATLNRNMYRAQLYMRGRVAAQFFTVCVLVGGALYLGFKPPPGFGGQPGVIPATEDSLTKRMLNRNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z431</accession>
    <name>A0A914Z431_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z431"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6765.t1">
        <property type="protein sequence ID" value="PSU_v2.g6765.t1"/>
        <property type="gene ID" value="PSU_v2.g6765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031052">
        <property type="entry name" value="FHY3/FAR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669:SF292">
        <property type="entry name" value="OS02G0262500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="393"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6765.t1"/>
        </source>
    </evidence>
    <sequence length="465" mass="53988" checksum="682F03B3F5E4C2E9" modified="2023-02-22" version="1">MKGNERINAGAVIQAYLNAGITELPTSMQINNYVSNKKRTLEISGDFNFVDMENMVREIKETESEVVEFKYRIDEENPSKTDWEIIITCKQMLDDQRNQKHGNIDSTFKLIFGGFPVMVWGYSDINRHIHPTGVAIISSETIETYKWLFEFLKSNRFCNGEWIPAEFVADNAQCITTALREVFPEVHRRNCIAHIIRHIFDVKFGEYGIDKQTDGERIKNEILELANHAFENHFDIAGAALIAKWKASDHEGIVQFADYFDREYIQKNKFWYAANGQGIRQNNGMEGSNKWIKRDFINRRLPLMEAIAALKKWLYVCAHKNYGNPAISVKTNEWIAAHDLKSVTKVIFSGGTWYVRRSKSEWDETDYRDYLEYYTDLDNVLDAGDVELFQKNIVVVTRSTLYENEFTCNCPIGALRTRCKHVLLIQVFCNHREWPNMPALRQTINGTARTRPGRPRKHTQALSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z480</accession>
    <name>A0A914Z480_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z480"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6808.t1">
        <property type="protein sequence ID" value="PSU_v2.g6808.t1"/>
        <property type="gene ID" value="PSU_v2.g6808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6808.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9108" checksum="1B7553B52C0214DA" modified="2023-02-22" version="1">MTMSSFGPLLMAAVSAHLTMRRCRLGHLALSGPGGADWSGCTRFPEIVESVPYPVQAYWPGFAFALGFGWFIAGAFADCHAARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4E9</accession>
    <name>A0A914Z4E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4E9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7570.t1">
        <property type="protein sequence ID" value="PSU_v2.g7570.t1"/>
        <property type="gene ID" value="PSU_v2.g7570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="270"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7570.t1"/>
        </source>
    </evidence>
    <sequence length="764" mass="86309" checksum="7C5F803938E2295F" modified="2023-02-22" version="1">MCIAVACQDVQYRYVNTKENPADLATRGATVSELKADTLWFEGPQFLKTPTLWPPGLQPIDILNLAPEIEATTFTCSKLLTPEPITTDSSTIDVRKFSKWNILIHSVILFLQFIAILSFKCKIKIKTTKDFTTSGSTSKRQKAIRLLIKEAQKRQPPPIQSQKKYRMFLDKEELWRCKHRVSNNAEFELHPYYLPPNDHLTTLIILYNHEKLHHSGIPATVAKLEQQFTIPKTRQTVKKVLKKHCMVCRRYQAKPYRQPDMPPLPTERVTQEKPFFRTGLDYFGHLWIKTTGEPQKVWVLLLTCFCTRAVHLEMVPDMTTLAFLRAFSRFTARKGQPHFLLSDNATQFHLASTLINGNVNSLQQKLTDKNITWTFIPALSPWQGGIYERMVGIVKTNLRKAIGRNMLTYDELNTVLCESENIVNSRPLTHVDSDGDNFTLKPCNFLFPLESYSTAETINTSDDDEWHPTKSTTTLLEILTRPVNALYSLELGVCKAELTTPPPDREKPASPTTTSATSDSQQPISDGPAARTRSRLQKARTNLSLLTMICLLLCQISNVHGDVGRCKEINGKVLQIIPSCIEAGIRILQVTGDKKCWIPIVCRGGKNPKHPASCSSRCSCPSWATDCSFYNGTETAISKIDYPPLKEALKKHTFEICSTNRTDKCSSNQQKIVAHKIQLFDGNEVIVKTFHLTTADVSKEDKPKCIGQGTITGTSKYCALNQCAPSGTQFCYFDQSPITYLVLDKLHIPIKAWGHHEIIFYGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5N8</accession>
    <name>A0A914Z5N8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z5N8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8003.t1">
        <property type="protein sequence ID" value="PSU_v2.g8003.t1"/>
        <property type="gene ID" value="PSU_v2.g8003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF12">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="5">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8003.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34847" checksum="FA6CF87686C72993" modified="2023-02-22" version="1">MEFVLKHSMFEHLREVPLKPDTICPSDSNSTSLIHEMLQQVRQLHPNSKAIHIGCDEAWHIAQDDRCLHALNTTFHNSTDKLKLAHISSIAKYAKENLNFEHVLAWNDLFDKIPVELLNEYKLGNYIIPVIWGYVEDVTTPGYFPPGMIQRYSQVFNEMSFGSVFKGANGATQIFVSMERYLSNLKSYLMFYKLNENFLTGKVTGTILTGWTRFWHGIQLCEILPEGIPLLVQEAIYMNDSNLNDSELENKTLEFFNCERHQIFPISYNGKLYNPRKEAIYSFCNFPGSDVYALVCLFYLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z603</accession>
    <name>A0A914Z603_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z603"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5670.t1">
        <property type="protein sequence ID" value="PSU_v2.g5670.t1"/>
        <property type="gene ID" value="PSU_v2.g5670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5670.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21455" checksum="94D358DF393658E4" modified="2023-02-22" version="1">MDGITWTNTSTPFLYPRPYHFDSDSIYVGTNPLPLKTGDFLFLYSGVTEDDDRTRTGCTILDAINPTNILYRQNGSLMSPKLDWEQDIYLTSIIPDPYGCPSNVGEIIGPNFISNAECFIGVYGIYEIGAVRVVTSWIDNDISSTTTSSDTCVDLDNTCSSYTSECLLSSYLPLMCKYCQKTCNLCNNPKCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z713</accession>
    <name>A0A914Z713_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z713"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7686.t1">
        <property type="protein sequence ID" value="PSU_v2.g7686.t1"/>
        <property type="gene ID" value="PSU_v2.g7686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7686.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8511" checksum="33279C7AD894DAC1" modified="2023-02-22" version="1">MKNEKFKDVKKGGNQVVKRIGNTSESVLYTAKRYDIKLPVKGAVNVYDKTVKAANGKATWAFRIDTPHKGAPTYHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7G2</accession>
    <name>A0A914Z7G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase M24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7G2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8265.t1">
        <property type="protein sequence ID" value="PSU_v2.g8265.t1"/>
        <property type="gene ID" value="PSU_v2.g8265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="9">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8265.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14023" checksum="7B4D138CA7A6D30C" modified="2023-02-22" version="1">MIKEKGLEAGLAFPTGCSLNNCAAHYTPNAGDTTVLKESDICKIDYGVHINGRIIDCAFTISFDHKFDPLMEAVKEATNAGIKAAGIDVRLCDVGEIIEEVMSSHEVELDGKTYVVKPIRNLSGPQIGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7M2</accession>
    <name>A0A914Z7M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7M2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6245.t1">
        <property type="protein sequence ID" value="PSU_v2.g6245.t1"/>
        <property type="gene ID" value="PSU_v2.g6245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6245.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21085" checksum="74150114646D3DCF" modified="2023-02-22" version="1">MECKPTCTLYDESEGEVAARSVSKVKIDTNSDSDTNVVPSRKKRRRRNAKRENPDMEVDNNKNSKGSAFLKPGETSTNANMEWESDPGMNSDDSCGYIDADDEQSDFPDSCIERGPKPEGTQSRKTRSGMNPSVQRKIERFYYSNQREMLLTQVLHIHPIERFIRNKKMSIIKRGRGIILLRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z826</accession>
    <name>A0A914Z826_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z826"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6402.t1">
        <property type="protein sequence ID" value="PSU_v2.g6402.t1"/>
        <property type="gene ID" value="PSU_v2.g6402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6402.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17502" checksum="BDA9A102619279FA" modified="2023-02-22" version="1">MSGIFASSDPGSVELYTLDDLKQMNLLDKTAVEYLLSNPMPDDDLLLVLDFVTQQTFHQKEQINDALRTFGGTRISPHVIQYRTWDDLLDARRRMFESHPQWFYTTNAQIALLHNCQNTTTIKSTLILALSEATDKFKLSKFKFFSVFVNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8B9</accession>
    <name>A0A914Z8B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8B9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8143.t1">
        <property type="protein sequence ID" value="PSU_v2.g8143.t1"/>
        <property type="gene ID" value="PSU_v2.g8143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="1">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8143.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15516" checksum="45E1DA6A29A4F31C" modified="2023-02-22" version="1">MAEFYAVQGLKNFCDKFLAASKKSVGKIEELYDVAEKYSLSELKKSVGFFFCHHVKKVCNSEVFITFKKPFVEFLFTVGSYEYNKETGFKAVYKWAEHRVLQDQAVDGDRNFNLQEAIKVEFSTFLPKFNFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8Z2</accession>
    <name>A0A914Z8Z2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8Z2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g88.t1">
        <property type="protein sequence ID" value="PSU_v2.g88.t1"/>
        <property type="gene ID" value="PSU_v2.g88"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g88.t1"/>
        </source>
    </evidence>
    <sequence length="803" mass="93563" checksum="AC5576D2030D88FF" modified="2023-02-22" version="1">MNVSPKCFGTSQYIHKEEHERECRRWQTKLDEAEEKFAEACVNNSDMLQIKAELNKKIVELEKNQRPLIEQNKRLNDRNRIIQQELKKVEEKLCYAQDDFLTLKDAYDRLGKENNLLKEQRAFPEKVKELDRYRTQVLEYSKCINALRQSGIEKDRRYDLLVQKFKRMKKCLTKRSDDDDRQSSYGSEGSTESSINLDTITEDIDEALEIDHTSFCYDHEVALKLNALAFGEEQILKEQLEVANTTINELQATLTSRDNMSKVQEEYLSTIEKQNQKLQDIQHTCNCLKIKLANSEEHNDLLEFQILEFREMSKDAEISTEDKGIETDVYISDSDAENIFEDIKAFVNMDASTIEKAKSVLKDLRRLACLKNAERDAVKKILQHIENLENKLSFAETELNMSTCEIRRLESVKIDEINELKNQLAEAEAQTSKKKKELKTELECAKKECSKATKNYLEKEKENNYLAACIKDLQVLLQKNETLTFDEKKRIAELEKQLTEIQAKYSQEINIAQQKDGEKLATINNITTELKTIKESFSNAVQEKDKLNDKIGHLQNILTEKEKTFEANIRELNANLSDLKEKYEKDNNILVQEIEKTRTELQQSNTSLKTTHDVCDVERKKVAAAMKEITEAKEKYEKEKQNQIAQFEKEKKENERALAEARTEIEALKAQIRPIGSLLERRFEETRYRLQEANKLNEKYEEMLKVSNSRTSELPSSKEDVYLQEIQQLKIYNHELEEQFASQMEIISALKKKFLLLNNNTDTAENENWTKLTAQPKNSIDDEQYHSEGSSSVGSYSIVRNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9W2</accession>
    <name>A0A914Z9W2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog subfamily C member 21</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9W2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8711.t1">
        <property type="protein sequence ID" value="PSU_v2.g8711.t1"/>
        <property type="gene ID" value="PSU_v2.g8711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8711.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11426" checksum="B3CE89E577DDC426" modified="2023-02-22" version="1">MSGGFILASIGIAAAGFAGRYLMRNQHLVKQAVEALPSAAFSKYHYGGFDAKMTKREASMVLGVSPAAKPQKISEAHKRIMIANHPDRGGSPYLAAKINEAKDLLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA63</accession>
    <name>A0A914ZA63_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZA63"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9212.t1">
        <property type="protein sequence ID" value="PSU_v2.g9212.t1"/>
        <property type="gene ID" value="PSU_v2.g9212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9212.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25736" checksum="8B7CFD0D6293F3F5" modified="2023-02-22" version="1">MNKFGLIFNLIFDFIESERGNYESLLKKLLPIARFILSQQSLYQRNRSSIIQRFYRFGKIDVALKLAEEYLDFATIIQHCYEKLPDVERQYQLEKYKTQFKNENFDIFLFEYYREHGLINDLLEQQGDRVEDFLSKHDEINWIRNIERREYSKAKETLRSIAYSAPNAERKKTLLSLAKLAALCEDEQNPEEVAQITNNLILLQHQEQISPDIAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB04</accession>
    <name>A0A914ZB04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB04"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7432.t1">
        <property type="protein sequence ID" value="PSU_v2.g7432.t1"/>
        <property type="gene ID" value="PSU_v2.g7432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7432.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11158" checksum="780AB934B714758B" modified="2023-02-22" version="1">MVEALLQMPDIDVNAVAYTNDTALIKCCRNDMVEIADMLLKHPTILIDKTGEKTSVEYNGRMAIHEAAACNSLQILKQLFSKGAAVFAHDVHVSCVYCMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB54</accession>
    <name>A0A914ZB54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9147.t1">
        <property type="protein sequence ID" value="PSU_v2.g9147.t1"/>
        <property type="gene ID" value="PSU_v2.g9147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9147.t1"/>
        </source>
    </evidence>
    <sequence length="563" mass="61315" checksum="14FFA34282B32827" modified="2023-02-22" version="1">MEYQVRDHDTLERIAACHDCTVGELVKLNKMHSRMVFPGQRIRVPVPQDPTTANTNSSTKSLNSQTTSDGYTLISTASPPQSPLDNPIKPPGSAVRQMSTMSHQSTTSPPRQSSITSGHGHVDAEDTDCLRRFLKVKVKQVTESDGTVTGTLLITPNCVMFDPDLLHPLVKENGPDLYGMVANMDDIVSVSVFKHDHSLVDKRESEASESKKLSFDCGPTEDDYRTAEENNLDTSGDVFSDAESGNTNSSNDIENSNHVNPPLSLTMSTDPQLPSIQEEGHVKLTPTPDNAPLNSVNSLEATLIKRRAISDAGVIPNDPNTNSPHIQQQQNPPDNCNVPDRPRAHSDLQPSTSLDSEQQQKSGFSRFSPSMTRRSFGRLGRTLSSRANSLKGTVTSGAQTVASGTQKVAHGVVTHTKSAAGHIQSGIETIATVPTSIVNVGSEILQEGQDLYGSFVAELKGEPPKSPVAIKREKSIATLESLRQKTHEARMTSINQNSIDSVFTKASINDESHDLFPSIESMSTSINPPVIGTPPDPPYYMTIRVDRKRMTKKNNNFRTQIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGB7</accession>
    <name>A0A914ZGB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hint domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9332.t1">
        <property type="protein sequence ID" value="PSU_v2.g9332.t1"/>
        <property type="gene ID" value="PSU_v2.g9332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hint" evidence="2">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9332.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14196" checksum="A81BB0EB745E1002" modified="2023-02-22" version="1">MDRLNADMVYAEDISPDQCLFVLKDGIDFVETRISKIEIVKEKGIYAPMTHNGNLVANKIFASCFNIINNSNMQLSLSQNLRDFANSAWAKLWMNESSNDVTEIELIPGLQILVDLLKLILPYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQS9</accession>
    <name>A0A914XQS9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XQS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10361.t1">
        <property type="protein sequence ID" value="PSU_v2.g10361.t1"/>
        <property type="gene ID" value="PSU_v2.g10361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10361.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21491" checksum="EAA47FCF87320E07" modified="2023-02-22" version="1">MFLFVPQILKIHRARSAEGISLISMLLGLVPALGTCAYSYEKQFVFSQYGDSVFVAIQMSIIVMQILYFSDSAPYAFAFMATMWAIVCAIMYHYIPFNVLYMIQAAGIPFIIVSKGIQILANYRNQSTGQLAFLTVALQFGGCLARIFTSLTETDDRLVLFVYLVASALNGIIFAQFFMYWGNKTRKQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSI7</accession>
    <name>A0A914XSI7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSI7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10943.t1">
        <property type="protein sequence ID" value="PSU_v2.g10943.t1"/>
        <property type="gene ID" value="PSU_v2.g10943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10943.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10289" checksum="C428124BF7AC1D58" modified="2023-02-22" version="1">MLNEEYGTATNIKSRVNRQSVQSAITSVQARLRLYSKVPPNGLVIYCGTILTDDGKEKKVNIDFEPFKPIHRFIYQCDNKFHTEVLQAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSU8</accession>
    <name>A0A914XSU8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XSU8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10349.t1">
        <property type="protein sequence ID" value="PSU_v2.g10349.t1"/>
        <property type="gene ID" value="PSU_v2.g10349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101:SF1">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10349.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21573" checksum="7C14E3D9C36E98C3" modified="2023-02-22" version="1">MKAIFCLFGKRKSGKDYCAEVLKTELNKNYGHAEIRRISDPLKEEYAALKGLDSSEELKTSGPLKEVYRAEMIKFGEDIRVKDYGYFCCKSLESIPSSTEYLIISDCRRPTDLGYFKSKFSNVFVIKIIADLKSRTDRGFIHCPEIDDAESECALDGFQDVDAVINNNNNDEKDERLKEKIKSLLAKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTK7</accession>
    <name>A0A914XTK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g103.t1">
        <property type="protein sequence ID" value="PSU_v2.g103.t1"/>
        <property type="gene ID" value="PSU_v2.g103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g103.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12689" checksum="8996BE9CFC25C104" modified="2023-02-22" version="1">MPIINGYRIDFSTTLTKFWIIDTFEIRAYEGNEGLKLLPPPSVIPPLYKCHAKRLTLRDLEISYADFKFLSLNAEDILLFHILVVNNEDGSIIPMEKIIQSLPKVEHLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTP7</accession>
    <name>A0A914XTP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NIPSNAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10342.t1">
        <property type="protein sequence ID" value="PSU_v2.g10342.t1"/>
        <property type="gene ID" value="PSU_v2.g10342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000003">
        <property type="entry name" value="Protein NipSnap homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="190"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10342.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33458" checksum="70FD8255C06D8671" modified="2023-02-22" version="1">MAVVRSTMLCQLNSARLVPFTSRFLSTTTTKEGEDLTVKQDEKKQGWISRFLSGPSYNPDGVDKQSHSSMLADTEVIYELQTHDVRNGEKDKYLDYYKKYSTEVTKATPGNELIGSWNVLFGNQDQSIHLWRYDNGYNDVDHHIKALLHNNSVRSAEKDIASMCGRRRTILLRSFSYWGEVKPRSPTHIYDLRSYVLKPGTMIEWGNAWAKGITYRKEHNQNVAGFFAQVGQLYMVFHIWAYKDMAARQYIRQHTWSKPGWDSTVAYTVPLISRMQSKILVPNEFSHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTT8</accession>
    <name>A0A914XTT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10385.t1">
        <property type="protein sequence ID" value="PSU_v2.g10385.t1"/>
        <property type="gene ID" value="PSU_v2.g10385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10385.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="56742" checksum="14A011A13D0D7B94" modified="2023-02-22" version="1">MCIEKVYFLLGKQLTKDFELYSDVARKDVDAVKSEAIDKSFIKSVTHSSNRSNKVSALGLDVVMHEDPLVAIKTKAELRKREIYDNPAIQMKLRKALLEEYQHDKKKKEKKKAKKEKKHERKNSRIEEGTRRQHHHHEEKKHRRHNSDDEDESRSHGRADSCHRCSSPAAKSSRKYSTNDKSPDRIKSKRHSESDKLPVRIRHDSHRSHHDSDSRRPDRSRKRSPSSSDDDKNRGKNDTRHHRSSPTTKSNRKSSLNNKSLDRNNSRRHSESEKPSVRHRHDSHISRRDSDSRRPDRSRKGGRNPSSSSDDDKNHGRRYSRHHRSSPTAKSNQKSSLNDKPSDSDQTRRRKRHDSSSSEDKEKQKRRRVSTSSSTSSPDDDDEYAPRTSTAVAAEDKKAEMERKRKEMMENANWRSENRKETIEKTHEILKKEFEESQAHIQTGPSFIRPMIQSAMDNQTLEDSINHRRKRAAGSSRDMQKSFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUM3</accession>
    <name>A0A914XUM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11647.t1">
        <property type="protein sequence ID" value="PSU_v2.g11647.t1"/>
        <property type="gene ID" value="PSU_v2.g11647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11647.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24180" checksum="AEB171EF6CE52C2E" modified="2023-02-22" version="1">MKNKRGKVFQEWCQAFLNHLWFGVTAAKGNGTLCQQYAVSALMHSTGVHEWTEGKMSDVLHDSQIGVQGGDDEAILKYDPSELPGSLIHEIEFKEFLKCGHAETNMGDKALLDTTCATYWVLLKAYTNDQFLNDLKHLSPYLATSALEGFHGLVSNIYRSKNHYLSSKSFENRTQLAVLHYNNNIFDEIAGKRKVIREVKMKAKHRGGDIVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWT6</accession>
    <name>A0A914XWT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWT6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10998.t1">
        <property type="protein sequence ID" value="PSU_v2.g10998.t1"/>
        <property type="gene ID" value="PSU_v2.g10998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MH2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10998.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23667" checksum="A95000501DF0C927" modified="2023-02-22" version="1">MYYEYSEKVGETYKSSATEIGITGFCDSSNNFRLNLGSIAKPNRNPLIRYVRENIREGVRFYNRNGDVFIDCLSNSPIFIQAPLCSHVMGHHLATVYRVEPGHSMQIFSARKFDYLIFEAQKRGPDAIAALQQICCCRLSFLKGWGENYQIQTVLEVPVWIEVLFIGALHELDLLIMQAKNSRHQHLLLQAAQQDIDDLSSCPSMSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXP9</accession>
    <name>A0A914XXP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription termination and cleavage factor C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11303.t1">
        <property type="protein sequence ID" value="PSU_v2.g11303.t1"/>
        <property type="gene ID" value="PSU_v2.g11303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription termination and cleavage factor C-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11303.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14976" checksum="D1AEC8D1C3526887" modified="2023-02-22" version="1">MRTINARDAVSMLHVEPPRLDFPFYKKSADEEGPNYVSTKPYQPPAPLPDHINVTSHRTLLRNPPQPIHTQTQQNEQAGYQPQQDEDDEEESAELLVQLLQLSDDQIALLPEDDRNKVRELRQRLRNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY82</accession>
    <name>A0A914XY82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XY82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11493.t1">
        <property type="protein sequence ID" value="PSU_v2.g11493.t1"/>
        <property type="gene ID" value="PSU_v2.g11493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018251">
        <property type="entry name" value="Crust_neurhormone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031098">
        <property type="entry name" value="Crust_neurohorm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01250">
        <property type="entry name" value="CHH_MIH_GIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR631098-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11493.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15443" checksum="4031848B8FE86176" modified="2023-02-22" version="1">MHNCSFIKAFSAIFYYIIKRNRYIVHYGLFHLAFYLFITSMIISSNIAEAKVYVVQTRSGNAVKPRCKVQQNSELHVLMDRICLLCHEMFSHERPNMRSDCRSNCFRTEHFRKCLAIFNPGRQAAKMLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYK0</accession>
    <name>A0A914XYK0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYK0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12034.t1">
        <property type="protein sequence ID" value="PSU_v2.g12034.t1"/>
        <property type="gene ID" value="PSU_v2.g12034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12034.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31403" checksum="4F23025C3D594BC6" modified="2023-02-22" version="1">MFDLYNYCSLQVAGNINNINKRIDSRNLAILVSRSKEISTVIDISTKKGLFSFVTGNVVNEEFFRKLEVSVEISSVKAIVFDGCEGDSNSTIERYGNRRQCHDFCQKHDVLCVILNDTDLAFGIAVSITKPEVKEGETVIVRLAVDGELMSDFLVRESDCYPTLPLFPLSGILFLDQWKCEYQQYGHPCKQLVIIKKNVNIVIYRYILNVVNCFKEIEKVSAVEPDEITSQIESYIVDTILHITHEKKRHLDLLSRIMGIFYVRVGKGLVMTIDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYR3</accession>
    <name>A0A914XYR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13084.t1">
        <property type="protein sequence ID" value="PSU_v2.g13084.t1"/>
        <property type="gene ID" value="PSU_v2.g13084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036697344" evidence="1">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13084.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29354" checksum="2F8D567015598F49" modified="2023-02-22" version="1">MLLKRLTILKMKKLLLLGFSFGYSQFNFTDDDQIVVLHAYAETFLKTGFLQDNRYQKLGFAKITACLRNFTEAEIQDVLRAFCDEWADHDGAFFKEIGDEIADFTIALHLHPLVGKAAVKFFKKEKKYVRSSVFGLICQIGLISSYRYETEVSKMLSLSLSKIWQFADDLETDGWIYTVIKDLQLSKIKAKFQAIIDFIKGCSTAAAVLSRGLTVLSTQLIESSSRKSSINVISGRLEDSGNNIAFIGRRLLIHWHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0Z5</accession>
    <name>A0A914Y0Z5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y0Z5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1388.t1">
        <property type="protein sequence ID" value="PSU_v2.g1388.t1"/>
        <property type="gene ID" value="PSU_v2.g1388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication protein A OB" evidence="7">
        <location>
            <begin position="209"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="6">
        <location>
            <begin position="357"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1388.t1"/>
        </source>
    </evidence>
    <sequence length="446" mass="49701" checksum="E4E476EDDD8EF46E" modified="2023-02-22" version="1">MENIQLSENFFQEFAEDAHFAEPQPVLQILQSRKIEAATICLRLRCSDGVFSYIHCGFDKAIAEKAENEIPDDPSKLPVIKVLAYKVLASQDKNTFIITDYDLISIDMPKIGNPKGHTGDADGQSIKIASFAETAEKFFPQLEENGSYYVSGSQNCIKPANKRFNSTGHDYEITLSHDSVIEAAEKQSYEAPKFVLKQTSLDKLSSLSGQYADILAVIDKVEDPVNVKKKDNTETYRRNIQLIDQSATSIALTLWGVQAEGFSGAEGQIIGIKNAFIREYNGTYSVAVNSGCRIELDPESKDTEILHQWYEGERPNAEVKSISTQANAVSNNLVDELRLFSFFSIPNLFVDPQRGIYFNNVGIVSQLRPDNVLYMSCDNKDCSKKVTEGNGLYGCGNGHSLSKFKYRYMVSMEISDMCGTAWVTLFDKAEAFFGKPAQEMGELQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1V5</accession>
    <name>A0A914Y1V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THAP4-like heme-binding beta-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14163.t1">
        <property type="protein sequence ID" value="PSU_v2.g14163.t1"/>
        <property type="gene ID" value="PSU_v2.g14163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF16">
        <property type="entry name" value="THAP4-LIKE HEME-BINDING BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4-like heme-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14163.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15909" checksum="E0852503BE1FE811" modified="2023-02-22" version="1">MTFGEELVILEAPMAKSSNVQFLNFSARAWSHSTKDHFHDEWGFVTVDPNGNATLMTTGNNGFTTYEVGVVRPNKLVLTLKDIGRISFSRDLPVEDLRRTFIKHDDTYMEQILEMRTATHPKQGYLEHTRVIYTKQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1V8</accession>
    <name>A0A914Y1V8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1V8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13440.t1">
        <property type="protein sequence ID" value="PSU_v2.g13440.t1"/>
        <property type="gene ID" value="PSU_v2.g13440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13440.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12031" checksum="DA3384A264330CA1" modified="2023-02-22" version="1">MSNFVTSESPTTADTVQIWTILVLCIIFCIAVRHLNDFFSGETITLVEEGTWGGRFKHREDYRFLTQVENDFAKMYFEITEADKRRNTIINRDILEEVDTDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3I2</accession>
    <name>A0A914Y3I2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3I2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13792.t1">
        <property type="protein sequence ID" value="PSU_v2.g13792.t1"/>
        <property type="gene ID" value="PSU_v2.g13792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13792.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11922" checksum="5C1921D14C8A5DE6" modified="2023-02-22" version="1">MATSHFHDIPKNVPGEIHPLMGAFISYHLRVDNTKHGRDHVKKTEPMIWKLLCFFKPEYEGDSCLKRYVNKDKRRQELKKLVTNDDGTFMTAEQQMKLFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4X6</accession>
    <name>A0A914Y4X6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4X6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13828.t1">
        <property type="protein sequence ID" value="PSU_v2.g13828.t1"/>
        <property type="gene ID" value="PSU_v2.g13828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13828.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12493" checksum="D1B040D38AF988FC" modified="2023-02-22" version="1">MKLIIGGYFRQATVFRQPQVSQQQDFNNIPAVPAPQPRKYRRNNTGTRAPRTRKNQSAAAIAAANAAVAVVVTTASSTDLIPIDSHQIQEMPVSTMSDTIVSSTGPIVMENIKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5F9</accession>
    <name>A0A914Y5F9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y5F9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14006.t1">
        <property type="protein sequence ID" value="PSU_v2.g14006.t1"/>
        <property type="gene ID" value="PSU_v2.g14006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF852">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="26"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="69"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14006.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28864" checksum="7A2138F323BB49C6" modified="2023-02-22" version="1">MSILHDDIILSPKQIQMRKFNGAKNVAIKEKRNNRWENNIVPYKLSNRYTTSEKLIIENSLKAIEKVSCFRFPKYTYQKNFLDIDKQDGCYSYVGKIGGRQLLSLSEGCVYDFIIIHEVMHVLGLEHEHQRPDRDKYIKIQYQNVESDKMANFGLISPNEVDYKDHPYDYQSIMHYDGTAFGKRDPQTGKKLVTMMPLKTGIELLDNFKLTTLDIEKLNSLGKCSNFAGLVSNFLNYTFFQLMGLFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y698</accession>
    <name>A0A914Y698_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y698"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13179.t1">
        <property type="protein sequence ID" value="PSU_v2.g13179.t1"/>
        <property type="gene ID" value="PSU_v2.g13179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF202">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="2">
        <location>
            <begin position="108"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="582"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13179.t1"/>
        </source>
    </evidence>
    <sequence length="766" mass="87679" checksum="0E68BC1B49EC7A9F" modified="2023-02-22" version="1">MRRSVNFDDIGGFTYGDSNIPHGNYSFHARKLTDGKYVSHSIEDVIYSLPKSQFSFRWLHDDNIVLKVGDDYWKLDTNKADLYGSRKHWINPGQIRLQDKQADFIFNSNSKYIAFGRAASQGFRHSRKCLYDIAQLENGNLRNFKPVGPLASGNEPLQLLEWNPAYGARDLVFVYENNIFYQESPDLPALPITSSGSEFRYHGVADWLYEEEILNDAKALWWSKSGQFLAYTLLDDKNVSKVILPYYTQKPYPTYHSIAYPKAGDAHQPAVYLWIWNKELNTTQMILPPDELIEQNPDLSYYLFSAQWIALEEVENDKRDYLIVVWANRNQNQIFITACQYGLPCRVLKKVEFSMKGMEMWADPSLLKVEHFSKTGFFMLLPHEYSDGNVYDHIAHIEVIKEGKYFPESGYHGGPYDISTIVGYDKERDEIFFTASGELIGEKHVYRVPYASAEDNVAPQCISCLIENCKNVEVNFAPSGNQMVLFCDAAYQDTVAYLKKTKNILQHWIINDGSKSTSFNPVYDIPNIRFDKIPLLSGIDANVRLILPPNFNSKYTYPVILHLYAGPNTFMVSNTTPMPLMTYLASVRQYVVVSIDGRGSANRGWKVRAPLYKNLGSPEIDDQINALRLLIQKYPFMDPEKVSAFGWSYGGFASSHIVEKDGGVVVKCSMAVAPVVDFRFYDSAYTERYMLQPSENKDGYLATSLLNSTAIKKFKNVKFFLAHGEADDNVHYQNSALLAMALQDHDIHFTQLVRNYFPFEITVFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y720</accession>
    <name>A0A914Y720_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BexD/CtrA/VexA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y720"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16004.t1">
        <property type="protein sequence ID" value="PSU_v2.g16004.t1"/>
        <property type="gene ID" value="PSU_v2.g16004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.560.10">
        <property type="entry name" value="Outer membrane lipoprotein wza domain like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1950.10">
        <property type="entry name" value="wza like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049712">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040716">
        <property type="entry name" value="Wza_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011658">
        <property type="entry name" value="PRK15078.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33619">
        <property type="entry name" value="POLYSACCHARIDE EXPORT PROTEIN GFCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33619:SF3">
        <property type="entry name" value="POLYSACCHARIDE EXPORT PROTEIN GFCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18412">
        <property type="entry name" value="Wza_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0625">Polysaccharide transport</keyword>
    <keyword evidence="10" id="KW-0626">Porin</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Polysaccharide export protein N-terminal" evidence="15">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="17">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="17">
        <location>
            <begin position="116"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Outer-membrane lipoprotein Wza C-terminal" evidence="16">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16004.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26299" checksum="3F53926D7A735AE8" modified="2023-02-22" version="1">MFYPYIGKVHVVGKTLAEIRSDITGRLATYIADPQVDVNIAAFRSQKAYISGQVNKSGQQAITNVPLTILDAINAAGGLTDTADWRNALMQNGDLNQNRLLYPGDILYVPRNDDLKVFVMGEVKKQSTLKMDFSGMTLTEALGNAEGIDMTTSNASGIFVIRPLKGEGGRNGKIANIYQLDMSDATSLVMATEFRLQPYDVVYVTTAPVSRWNRLINQLLPTISGVRYMTDTASDIHNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7E5</accession>
    <name>A0A914Y7E5_9BILA</name>
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        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7E5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14666.t1">
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        <property type="gene ID" value="PSU_v2.g14666"/>
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    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF171">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="201"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14666.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="36996" checksum="8BDA986CECF6ADC2" modified="2023-02-22" version="1">MTEIISDPILPFVTNIPGGIFPGKAITIRGSSSSAHPHQFSIDLCCGLLVQGDHQDNKALHFNPRFIKKKGIFGSADEDIVLNSLINNKWGAEERTGNCLRSDGPFTIRILILQSYFKIAVNGKHLADFVHRIPYTSINTLFIQGAARIDVIEFEGSVDESSTPTENSEPIAIGHGGTSTPASPTGPSADAIIRKPDVPFVHSFRAGSLNHTKTITLTATPKMHATIFTFNLMKSGDYFFHLRVDFPHHGKSNGALVRNHCINNRWASEERVISKFPFTQGITFDLIISLGSEFLTAELDGQRIFTFNYRPGIYLNEVNIVSITGDLNVQKFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7R5</accession>
    <name>A0A914Y7R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7R5"/>
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        <property type="gene ID" value="PSU_v2.g14791"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF21">
        <property type="entry name" value="INNEXIN EAT-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14791.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10055" checksum="8B901C00822DE258" modified="2023-02-22" version="1">MALEAGFFYLPVIFWSQMNTKSGLNISNIVKIVQKVDSTETAEREKAVDTICRYIEDSVRLQKVRREGSSYTDQYLTMGLLHGSYLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9J4</accession>
    <name>A0A914Y9J4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9J4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16104.t1">
        <property type="protein sequence ID" value="PSU_v2.g16104.t1"/>
        <property type="gene ID" value="PSU_v2.g16104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16104.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27941" checksum="2A40CC820B4ED09A" modified="2023-02-22" version="1">MWNLTRDICKRQVNVLSIDENAHSEVFYNENEQHLCLNINHTGFKALLKNLLVTDVLEIYSCNLFKPSLRKSLNISEFYFTKLDLISCDINKDDLKHFLHPLVVEFASDNSTVRPNLQFEELLEMLKDVEIMRIDISNLKFTPNIKNIALDWKREKLIKSFAFMRLPKNFSTAICIEFIEKFAAPDSEFNLSFARTNRGFHERYHSTIQNAIDKSITDDRSHKGLAGVTRWRCEEQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9P0</accession>
    <name>A0A914Y9P0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9P0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16925.t1">
        <property type="protein sequence ID" value="PSU_v2.g16925.t1"/>
        <property type="gene ID" value="PSU_v2.g16925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16925.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24919" checksum="48148F54B0E70D5D" modified="2023-02-22" version="1">MFNSSTESDTETGNENDSEGFELSSENVGDELDGDSDEVISIKNLPKEFRKAIIHKNDETKQQEIVIFVDNDNTLCYRYRFYFKKNGYYDNYCPGHSSIKKGASGVLEFQEPTSEHSNDSCQPSKYYPKKFKEPYFKIEKTDGGKDRLDTYEKMGDGFCKYGYTMPNGGFRCNKCQHIPDHNVYATVWKYKNREKYVQLNGTHVCTPTFVESLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9Z4</accession>
    <name>A0A914Y9Z4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9Z4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15585.t1">
        <property type="protein sequence ID" value="PSU_v2.g15585.t1"/>
        <property type="gene ID" value="PSU_v2.g15585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37431:SF3">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37431">
        <property type="entry name" value="PROTEIN CBG06927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15585.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24207" checksum="AD12BA21E70258C0" modified="2023-02-22" version="1">MNSAECLMELDQRPSVKHCHDETLRDIEKANGESGITMPIKLDRMCEALNFFSGCVRHPIRHNCGFEAWQVIFRVLKDTTKTLMPACQFTGTSTKIAHNRHHSKPTPANSEAGHLAKPASVDPREKPEKSDIHLTNHGIPESVSYNRETSSDHRNPSFSEAEDQQPHGDIIVVTEEHAQFSQLEGKPESVPSSAVAFGQYISLILFNAFIFYILII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA34</accession>
    <name>A0A914YA34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA34"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16147.t1">
        <property type="protein sequence ID" value="PSU_v2.g16147.t1"/>
        <property type="gene ID" value="PSU_v2.g16147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16147.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="33918" checksum="BF165F48A33393D1" modified="2023-02-22" version="1">MKVLYSKIKAAEDDIEKWFELLLEADIDEFVIQNVEYRIAINLHDVKLWQTYIDYLKRIDPKRMLLWFSKYCRFFLDDFKMKEKFKAEMEEYNHAIELPWSNLFDFEEAFVFMDQSKNNNLDDDMQSTDNENILFDDKNQVQSDEDMDDGNKSRVSESEIHTMQHFCAKFFETTKHQNFALPRPIMYYILKNANDIVLQKLFKSCKYFFGEKFTPICYSLVETHKETSYDNEKLSLNYKDIKKRLSQNTFVTTVISLGLYSPRNFNVKRNYSSSFSIRSKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA45</accession>
    <name>A0A914YA45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Alternative oxidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16304.t1">
        <property type="protein sequence ID" value="PSU_v2.g16304.t1"/>
        <property type="gene ID" value="PSU_v2.g16304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16304.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36398" checksum="C04DF7A5509C748A" modified="2023-02-22" version="1">MLNRSGSILKRTVFNLSNVTLRQPPNYYGLIKCKSTSTTPTGNSQPYNPMKTIQSDIPPENKPSNAEETLSGYLTRHEKGISLPVRPEFLRAKPWTTEELKAIDINVYHRKPKNISDYVAFGIVKFLRLFADGFFRKRYVHRAIVLETVAGVPGMVAGMFCHLKSLRRMRNDYGWIEKLLHEAENERMHLMIWMKVTQPTGFERFLVTGAQGVFFNLYAFFYLFFPKTAHRMVGYLEEEAVISYTAFAKQIEDGRIDNLQAPQLAIDYYNLHKDALLLDVVYAIRADEASHRDSNHEFADRILVQDENLSHKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC64</accession>
    <name>A0A914YC64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-type lectin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YC64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17805.t1">
        <property type="protein sequence ID" value="PSU_v2.g17805.t1"/>
        <property type="gene ID" value="PSU_v2.g17805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="L-type lectin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17805.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23063" checksum="F5491A3F526D9800" modified="2023-02-22" version="1">MSNLTDGLTQQHRYELCLRAENIFLPRNGYFGVSAATGALADDHDILDFSVYSVLNEAPKPAQPIPQDERQRYDAEFAKQMEQYEDERKKFKQEHPDKAKLDNEEEEYARHFEDAAARELRLIYETQNAIHQVMQQMEAKLAQIQQAQNVHTSMLQQRGGVPPAQTGQQQPPPPVGGGGVGDGFQQHEKNEVMQGVRDLSSSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCH3</accession>
    <name>A0A914YCH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g170.t1">
        <property type="protein sequence ID" value="PSU_v2.g170.t1"/>
        <property type="gene ID" value="PSU_v2.g170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g170.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8429" checksum="055B07A300A9EDC3" modified="2023-02-22" version="1">MVKESEKVNPFEFKERPPTFLNHKQALIQYLFDMSHLIKPNSFFTSTFIPHLNQSIYGVYGRKQCDTTPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCT4</accession>
    <name>A0A914YCT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCT4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15276.t1">
        <property type="protein sequence ID" value="PSU_v2.g15276.t1"/>
        <property type="gene ID" value="PSU_v2.g15276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15276.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23615" checksum="CE69E6D9816848F3" modified="2023-02-22" version="1">MHHDVGTVLERAQQERGGHRVVDDQWHAGGMRDLGDGRDVGDVAARVADRFDEHRLGAVVDQRGERRRIGRIGETRLDAVLRQRVRQQVEAATVQRAGGDDVVARLGDGLDGIGDRGLSRGQRQRADAAFQRGQALLQHVGGGVHDAGVDVARHLQVEQVGTVLGVIERIRYGLVDRHRHRARGRVGTVAAVHGQGFQLPLRVAHCTRLHPGKPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDD4</accession>
    <name>A0A914YDD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDD4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17304.t1">
        <property type="protein sequence ID" value="PSU_v2.g17304.t1"/>
        <property type="gene ID" value="PSU_v2.g17304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17304.t1"/>
        </source>
    </evidence>
    <sequence length="578" mass="64820" checksum="14514165CC29C622" modified="2023-02-22" version="1">MNPQSTEYSATITPLLMYYCAMALMLSMIAFFQYACFNYVALSVIRRLRRSFFRLMLHQSNEYFQIEENQFAINSFCSDLQALSTIIIDILPGIIIAIVQLVAAAVISYLSTWRLSWLISALAIGCGIWVAILQKFIQLETINEAKLTLKLSQSIDSQEKYQKLLKQQMNSGIRKGLLQGTLTGSLQFFPFLGWGAAALYGNWLLGRDLMNLPSYIYVCVSTLIPACVRIGQLPQLLIPLIVLPKIGKTMKTVKTEISKISTKDNDVDAKQRKKEFLISFLKTEIGVLPEELNGYPSPTFKQVHKDASSHWFLYFVGFLCCGMVGVSMCALTKLNGNMFEFYNKTNIRTFFGRGARISVDYLIVGVTTFICGIIAAFDNHLGAFIIAILGIICAILSNVHKSLTFTFLTSVAFTLQVVAQIFVIRFAEICTENANEVLHQKGLEIVSTFEAIEDISNRLDDIQKLYNSYLTFTFRKQYSTIFSKALRFSFIFAVPQVTQAISYAMGSYMVINKILTPVSVYKIVQTIYNALGGVAIIAQYPQDVQASRLAAQKIDENLELSNIMIHKKNVSVSATADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE25</accession>
    <name>A0A914YE25_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE25"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17549.t1">
        <property type="protein sequence ID" value="PSU_v2.g17549.t1"/>
        <property type="gene ID" value="PSU_v2.g17549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17549.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9899" checksum="2DFB1988956C5952" modified="2023-02-22" version="1">MSLMKIVCKDDAPSTPNFAYINVDPNVHQLYGNGANDLAFELKLGRGETMDIWYYSLLIQSTSEIDNAIDQFEKSDADVETDNSLDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE97</accession>
    <name>A0A914YE97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YE97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18580.t1">
        <property type="protein sequence ID" value="PSU_v2.g18580.t1"/>
        <property type="gene ID" value="PSU_v2.g18580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18580.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13279" checksum="042752AE514160F7" modified="2023-02-22" version="1">MYWGYEVLSNSLLKNMYLPSRFFPLLTYCRAPIVADNVYVQTTVNCILGMNAYYEKLYVLTYFMLLGIIAASFMSAIYYTILFITPLRTNTIQNLLDVRFDFFLINDLLKSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE99</accession>
    <name>A0A914YE99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17619.t1">
        <property type="protein sequence ID" value="PSU_v2.g17619.t1"/>
        <property type="gene ID" value="PSU_v2.g17619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17619.t1"/>
        </source>
    </evidence>
    <sequence length="491" mass="57222" checksum="6190D87B3CF9E761" modified="2023-02-22" version="1">MSYYETTPINRFNDLCYDLMSRRRFFDLRSYSILVVDQLFNSSTTDLCQLPQKSVDLPKFEHLIGVKSELFQHLCEDDRLFHHFLYSLGTHCMKFRIQCDVLYSSLYLWYFNSVLSYLLPDNDSALIGLKKLNWFCAINKHSATKSALRLLKPQVIAASYSPDLFARTDGFQSLYPRVFDFTKFMIECLSDRTAIPYEGQVVTLKHMIQYYMNFLLASTNDADFNSFKEKLRSLNWVTTRVKPFLVRWLQNRALDDLYMELVDFWTCLIAPDDSLKTREQFTKFFQMFTKEFGDIFYIIMDRCLIVDLSIPSHIKFLSFIVDHVFSPVMISWYQKMGFAVDDKMTQIQNKIFNYQQAVESDIKEKQKVSAQNKVAAFFGIVQNIMTTPPECLRELQKILDSLTAKLGGKEPSLSTSGLQLSNISGKISNISGNDSTLSTSFHPLANSTPVRKTPDYRTDPITKLRHLTSEGRTQLEFHHMLVHWKMNLWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEI6</accession>
    <name>A0A914YEI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone DnaK</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17710.t1">
        <property type="protein sequence ID" value="PSU_v2.g17710.t1"/>
        <property type="gene ID" value="PSU_v2.g17710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17710.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="28869" checksum="241421C4AE43C963" modified="2023-02-22" version="1">MDGGKARVIENSEGDRTTPSIVAYTKDGEVLVGASAKRQAVTNPKNTFYAVKRLIGRKFTDAEVQKDIAHVPYSILAHDNGDAWVATSDGKKMAPQEISAKVLEKMKKTAEDFLGEKVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKGDNKDRKIVVYDLGGGTFDVSLLEIANVDGEKQFEVLATNGDTFLGGEDFDNRVIEYLVEEFNKDQGIDLRKDPLALQRLKDAAERAKIELSSAQQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEN2</accession>
    <name>A0A914YEN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEN2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17918.t1">
        <property type="protein sequence ID" value="PSU_v2.g17918.t1"/>
        <property type="gene ID" value="PSU_v2.g17918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17918.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16305" checksum="EFD3FACE449FA3D7" modified="2023-02-22" version="1">MVKTRSGRVPQVDSPSAVPLKRSRAVADDASSSPLQVPEDVETDTLGPLSDGSTSFKSPGTPSRVQTSPDSSDDDEDLVSCADLLSELEHHEVNVQLQMEKVEEAFEQGTSSLSTLVSTYRDVYSKLKGSRNVYGCLESELRKLGRDDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEQ3</accession>
    <name>A0A914YEQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17779.t1">
        <property type="protein sequence ID" value="PSU_v2.g17779.t1"/>
        <property type="gene ID" value="PSU_v2.g17779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF38">
        <property type="entry name" value="PROTEIN SNAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17779.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35202" checksum="51F3B1C66DC8E19D" modified="2023-02-22" version="1">MPSTASRPLISNFDGGRNLSFHFHHSHSVISPLMRPLLLPSIVDVSQIQAMYSAFQLRFLLAKQQHQESAASEAVAAAASLSLKTIPTPTIPTSTTFSNLFTSSKLQQQQQPLKEISPSKPAFSIDDLLRNSEETLSVESEIKKECLPTIDYTAEELQFSDGRCKRRLQTPESQGSASSSISSVDQCHGNGRYKCDQCGRNYATSSNLSRHKQTHRSMDGPHAKKCSYCDRVYVSMPALSMHLLTHEASHKCEICNKTFSRPWLLKGHMRSHTGAKPFRCAHCQKAFADRSNLRAHMHTHTGLSNIIIYFNKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFV1</accession>
    <name>A0A914YFV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19178.t1">
        <property type="protein sequence ID" value="PSU_v2.g19178.t1"/>
        <property type="gene ID" value="PSU_v2.g19178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF72">
        <property type="entry name" value="GST N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19178.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9837" checksum="4DC39A728E9675D3" modified="2023-02-22" version="1">MAKQDLSILSFYLGDKPYFFGTKPTSVDATAFGQLVTITDTPLANPGIKSFMEHSTPNLIEFVHRIKQTFWPDWESLCSTLALNGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGF7</accession>
    <name>A0A914YGF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1840.t1">
        <property type="protein sequence ID" value="PSU_v2.g1840.t1"/>
        <property type="gene ID" value="PSU_v2.g1840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1840.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="28951" checksum="73FFB0BD2EB1E9A6" modified="2023-02-22" version="1">MGDDSVIECSSFNNGPLLGRTSYNQGKTNIRMNITPSTENSFVRTLAVDYFNGMIYCRLARRVQVPRDINRNQAFQLDDQHHILLSSGPTTSDSNGNGLLQVHSLDRNSNNFPYASVETITVNQYRIPLGSVIPTNSYQPYSQNGFNGIQSSSITFNNTQIPLIYPGASGMAPNPSVQQPNLQYNGPTQSFQGPGNLPNNNQGQGSVTPFQGPSGSSMNPQGQGYFYTTPSPNQQQQQPGQFHSTTRLFSGWHTAWIIYNTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGM1</accession>
    <name>A0A914YGM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGM1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19457.t1">
        <property type="protein sequence ID" value="PSU_v2.g19457.t1"/>
        <property type="gene ID" value="PSU_v2.g19457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009689">
        <property type="entry name" value="DUF1280"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06918">
        <property type="entry name" value="DUF1280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19457.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34362" checksum="D86517CF7FCA0663" modified="2023-02-22" version="1">MKTEIENQKKEFEAEKEKLKKEREREKEEQRKKFEEERELEKEEEHKKFEEEKEKLQKYFKFEKNILEKEVAKEKEKSRILENQLVQQMYAEFDEEIKIVEKEVIIDGVRVTFSEIINLKEVLTARIQRKLDNDTFVEDPFDKNKISLVFFGDDGGGTFKGGISIGNCDTPNSPDNFTVTVVVNGKLTKKIMEAVLGHMASQIEGIDVIIVKENGEDREFRAEWSLGGDYQWDLLSCGRKAAGCNCCCIWCRFNRKNAKIFKDPSALKRGEKRETFDELPDDEGEMAFRNITSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH40</accession>
    <name>A0A914YH40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanylate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YH40"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18105.t1">
        <property type="protein sequence ID" value="PSU_v2.g18105.t1"/>
        <property type="gene ID" value="PSU_v2.g18105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="4">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18105.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15928" checksum="29AE2FF2912AB20D" modified="2023-02-22" version="1">MLLSVKRLMVSSIRPIVLSGPSGGGKSTILKRAMKDHPDAFAFSVSHTTRDPRAGEVHGSDYWFVPRPEMEQMIDKGLFLEHAQFGGNLYGTSKKAVNDVQKSGKICVLDIELQGVKNIKKTDLNPKYILIRAPSIEELVSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH75</accession>
    <name>A0A914YH75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH75"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1666.t1">
        <property type="protein sequence ID" value="PSU_v2.g1666.t1"/>
        <property type="gene ID" value="PSU_v2.g1666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1666.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10348" checksum="C4887A73D38176AD" modified="2023-02-22" version="1">MNQVNQVNPPFQLYEIHIFDGDETKLVPGMRVRISTGAIFTLDSIPFPDRTDPQCKKLNLKAGQKFRKKVRKLIELHNKYLQVLANMNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH83</accession>
    <name>A0A914YH83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18826.t1">
        <property type="protein sequence ID" value="PSU_v2.g18826.t1"/>
        <property type="gene ID" value="PSU_v2.g18826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18826.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14169" checksum="1C77D48DD7D30C55" modified="2023-02-22" version="1">MAKTSAALTTKFDALLMRAFYRNESRVLLYPKICDTIIPYQVEIVNAFAKYFGIYFIERVKSMTYTLENPAFIREKDIDEFLLKKKHIGFRRIANGKVKEDFKNLPFFGEIEKHLILEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHY5</accession>
    <name>A0A914YHY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHY5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18408.t1">
        <property type="protein sequence ID" value="PSU_v2.g18408.t1"/>
        <property type="gene ID" value="PSU_v2.g18408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18408.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17624" checksum="0EF80A195E67992D" modified="2023-02-22" version="1">MYFVCKWVENQAFANAVFNVKEYSILQLSQILPFIHFESMSSDFLMDFVIRNGYLFGFNTLSNIVRKKIHHDVEVTDINGRKMCGTMFDRNNIIDKIKDIKSEAWIDKNGCYWDFVKPFFYDKSKYSMKKGNAKYQLLIENGHLLVTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI20</accession>
    <name>A0A914YI20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16965.t1">
        <property type="protein sequence ID" value="PSU_v2.g16965.t1"/>
        <property type="gene ID" value="PSU_v2.g16965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16965.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18964" checksum="74F98FC5432383B7" modified="2023-02-22" version="1">MFGFFFLWFYLPICGAQVVGYMLVLAGVMKHEPRFLLIAKCILAVTIPISGLLAILFFFVLILSFGYFFYTFVFIIFIGVFFTGFAVIIVHRAHTSMLGNGGNSSNSSNVNHPPMPPPQPQPMSSPPPTSMPYNNGSSQPPPPPPPPRHAPQYEQTPVPAGYGFNPSEPGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJH7</accession>
    <name>A0A914YJH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJH7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19672.t1">
        <property type="protein sequence ID" value="PSU_v2.g19672.t1"/>
        <property type="gene ID" value="PSU_v2.g19672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19672.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19506" checksum="C6509B3F694C58F4" modified="2023-02-22" version="1">MVDQQKIRAKNGEKESMDEIIQNVEKQIKEMREKFHNFEKPQNVTIVVDFNFLSMVPHLRRFGYKTFDQRDVEGGEHFSPEQRVKTLSAFMKDRIADGTITHCFLLTESRSNIRFSREVEIDELKFINADLDETESSIICSIMYDTNTIFDTSDVLNRCIVSFYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJU9</accession>
    <name>A0A914YJU9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17578.t1">
        <property type="protein sequence ID" value="PSU_v2.g17578.t1"/>
        <property type="gene ID" value="PSU_v2.g17578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="107"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1163"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1244"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1163"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1244"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17578.t1"/>
        </source>
    </evidence>
    <sequence length="1362" mass="153779" checksum="4C5CAC7FE7C3089E" modified="2023-02-22" version="1">MKGKGKLKKDIDEDADESKEFDDNGPIEEFLDKMETEKAISADFLRGDSALTKQLEAIQSGKCSKLIWRGAEAREHFRLVWKNDGEVLKKLFPIFTSVAKDNTCPMDILFYELLIVPPNKFRPIRVFKGDRFEDPQTVGFRRIMEINQLITYVKASINESGYTVGDADIRTSIEAKLGKGTLVEKLHRAYLDLQLKVNSLYDCELNKMEARPIPGIRQLLEKKQGLFRMHMMGKRVNYACRSVITPDPYLDVDEIGIPEIFAKKLTFAETPNALNIQELRQAINNGPEKYPGANFVELKNGRKEVIHAEDHFADDRRGKARRLHAPTDDALNVGMKSKEENMEIKTVLRHLKKGEMVLMNRQPSLHKPSIMGHRVRILKTQKALRMNYAPCKAYNADFDGDEMNGHFIQNRIGQVEAAELANVGSSYLVPKDGTPILGLIQDHVVSGVLLTVRDTFLDKQEFMQLLLAAFAQTTQRIRMPPPAIIYPRKLWTGKQIVTAIVQNSSPNNAHLINLIAKAKTSLNCWKVDGYPSPKHEMSESEVIFSRGALVNGVLDKAHYGATQYGLIHCCFELYGHEIATKILSCFSRCFTTYLQSHGFSLGVADILVKENANKQRKQVIRDLRKVGDNVVRKTFGLPDDSTRIQNKHVLASAYNNARGETTDVKMYDFTMKQTLGKLNDKINEACIPEGLIRRFPQNSLQLMIQSGAKGSAVNAIQISCALGQIELEGQRPPLSATGRTLPSFRSFDSSPRAGGFVDQRFLTGINPQELFFHTMAGREGLIDTAVKTSRSGYLQRCIIKHLEGIKVQYDGTCRDHDGSVVQFRYGEDGFDVGAATFLNPKQFPFLLDNLEALRKKCVQKNVSQACFNIDKAEKAYKKIKRRQKEYEANQNADNRRVFSSGFAEFSKNHFGEDKKEVIYPLWKALTKEEKAEWDAKAVRRVPDSVDVQFNPYLTLGALPEKTLDQKEFSLSLSKEIDDERLRHTLFWKGLKALVAPGENVGLLAAQSIGEPSTQMTLNTFHFAGRGDMNVTLGIPRLREILMTSGKNIATPTAEITIRDSATEEDIERLKQIFNRVYLKKCVKKITVKERLDVGVTGASRIYEISVEVLPSRARDPAARHLTRKMILKQMEATFIKSVCRIIMSKIRDAQEFVAIVHRKSKGSAINKNSASGENDEEGQREYAPNDDGASSDEEVLPGAEDANEARLANRHIDDAAEYEGEEAEEEDMQVRDPQMTDNFAVYSDDSEAEEENENDETMDGTSANNRDKSKDEADIVRKTAVIDAASFVEDYQFDTKSNRWCIYKLRLNLDRYKVDVNSIVDSVVDKFIVHQTDKIEKCVIREENKKGKDIKILQTQGINVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKD9</accession>
    <name>A0A914YKD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKD9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19991.t1">
        <property type="protein sequence ID" value="PSU_v2.g19991.t1"/>
        <property type="gene ID" value="PSU_v2.g19991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19991.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16387" checksum="6F42CBCA022B0EAD" modified="2023-02-22" version="1">MIWQNRWFLWLLLIFPLIQAIFQFTPYVLTFSSLVLICSTCLAAIFNTLTFLKLYLVQHADNIKRVKEMNLMIVSFVIFIAQVLRSSFDVCLFLGDNDAQRFMFTIFPILQCIFAISGSISMLTLRYVFISFCIIDKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKH9</accession>
    <name>A0A914YKH9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-deoxy-D-xylulose-5-phosphate reductoisomerase</fullName>
            <ecNumber evidence="5">1.1.1.267</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:13719"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YKH9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19386.t1">
        <property type="protein sequence ID" value="PSU_v2.g19386.t1"/>
        <property type="gene ID" value="PSU_v2.g19386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525:SF0">
        <property type="entry name" value="1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal" evidence="13">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19386.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="14610" checksum="51599F01AC61CCC3" modified="2023-02-22" version="1">MAAIIGAAGLPSALAAARAGKRVLLANKEALVAAGRIFMQAVQEGGAQLMPIDSEHSAIYQCLAGELPPEPGQPVAVLRRLLVTASGGPFRSRNLSELEGVTPEQACAHPNWSMGRKISVDSATMLNKGLEVIEAHWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL24</accession>
    <name>A0A914YL24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">S-adenosylmethionine mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YL24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20239.t1">
        <property type="protein sequence ID" value="PSU_v2.g20239.t1"/>
        <property type="gene ID" value="PSU_v2.g20239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="82"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="175"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20239.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29398" checksum="C867D2115F09248C" modified="2023-02-22" version="1">MDSHADICRWLISGAAAGLSVDLSLYPIDTIKTRLQSSQGFIKSGGFKNVYRGMGSVAVGSAPGAALFFTTYYAGKQVLKTESAWGDAFRASFAEMIACLIRVPTEIIKQRAQASTSQKSLSMIARNIYKTNGFLGFYRGYSTTIMREIPFSFIEFPIWEFLKRKLAVYLGRDKCQPFESAVCGSIAGSFAAAVTTPLDVVKTRVMLYEGVKHASAISMFTKIYQNEGIAIFFSGIVPRTLWMGIGGYIFFFAYEFSLQTTHRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLC3</accession>
    <name>A0A914YLC3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diphosphoinositol-pentakisphosphate 1-kinase</fullName>
            <ecNumber evidence="3">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YLC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21146.t1">
        <property type="protein sequence ID" value="PSU_v2.g21146.t1"/>
        <property type="gene ID" value="PSU_v2.g21146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21146.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18076" checksum="C6F00583C9DAAD16" modified="2023-02-22" version="1">MFEESKISIAQRVCTPLLAKLRNDLHRCVQDPEESDETTRLDPRASEGIATPMRHVRTRLYFTSESHIHTLMNLIRYGGLCSPDDQKWQRAMKFLSSVTEFNYMTQVVLMVYEDSRSEAGKEGTDRFHIELLFSPGLYPCFQTEKERIYETRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLT3</accession>
    <name>A0A914YLT3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLT3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20323.t1">
        <property type="protein sequence ID" value="PSU_v2.g20323.t1"/>
        <property type="gene ID" value="PSU_v2.g20323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20323.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13618" checksum="01CCA5FE51C724D8" modified="2023-02-22" version="1">MNPDKKFLVELQRQYFNSGSPTELKHRKKALQTLRKILTTDVDELLEAIEADLRRQKGVSHAFEIANAIVEINYYLENLDEWAAPTYVEKTLTSALDTPMIIKESKGVVLLIGPWNYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM37</accession>
    <name>A0A914YM37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2207 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM37"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18385.t1">
        <property type="protein sequence ID" value="PSU_v2.g18385.t1"/>
        <property type="gene ID" value="PSU_v2.g18385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18385.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="52381" checksum="C1DE98D756A13B50" modified="2023-02-22" version="1">MLAWKPYKYLVKDLIRYGFVHDHKIELRDKDYLSKVDQEKIEKIEEKVKPRLMISNGSLKSTKKFFADEKLDAGMDVQMQVINVMKQVGKIDENNWWIFWLILKIAFAIFMAWSIPGLILMAIDIAINFNSYFATLLTVIAAVGTMLYFIQSFKAKYITQTGREAPQERYTQLIDFHSNALKMNDKHRNDSKLANVITTSIASKVKAKFNIKIEKLSKSSVESKTIGVRKFFRLFPQAINDQPHSWRLFSEGIRDSLIRIKPEITSKYFEILKPQKENEEINVENTLIECEKLNQTFKIEMPTLTRKLLASILLKITEDAIASINDSEEKGEDSEEEEIPKEFIEAGTEINIDDSDSGNESDKEIKTEGRRYSQKKIDSLNENFTKWFQNKVDDIFEHEILHQFTKPLLTSFTKYIENAKPNTEKPNGFDEYLEENSDNKYSIEEKRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMF7</accession>
    <name>A0A914YMF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Helicase SWR1</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20109.t1">
        <property type="protein sequence ID" value="PSU_v2.g20109.t1"/>
        <property type="gene ID" value="PSU_v2.g20109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="444"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="929"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20109.t1"/>
        </source>
    </evidence>
    <sequence length="1187" mass="136857" checksum="8FFD4AEA3BBFCFC7" modified="2023-02-22" version="1">MLNGNISEEESRTKNVFNGDINDGAGTSMSDKDRNQDHISDKNDIWDVSAGLKELESFLSADFHCNNVKANLAFVAAYISTKDEDNELKMFSTKLKLNETQKEAIEFLKDLDKDGIYDIDYKSIQPPQSKSKSTLNYWDSFKQEHRWIGKEQKNLEKWQRKWTRKLAKECQKKAIERGKSDELLKTKEETTAKKGAAKVAGIIEEFWKNIAKVAHFYELKLREDVEQKRLESQLMNVIDRSSTLTQLMIPGSKKKNAELEGLSQDPEDLDSLLASLPPEYLAAISANVDFEEKIEHVSLSEVIPRRPSPIKSPNKISTNGFKEADLPLKDTNGFGEKRKANNRLSLSPPKAKKSKLVDDDDVETPMDTDIPSNETTDESLNQPLQAQASATSLHDEEMNDLAKVAESFRPTGSTYETAKVRTEVPSILFATLREYQHIGLDWLSSLFENKLNGILADEMGLGKTVQTISFLAHLAENKKIWGPSLIVVPTSVLLNWEREFKRFCPSLKVLTYFGSTKERQEKRKGWKKPNSFNICITSYDLYIRDSRMFKWRAWQCLVLDEAHNIKNSKSLRWNKLLSLRTRIRLLLTGTPLQNNLMELWSLLYFLMPSVFSSQDDFKNWFNDPMSAMAEGAAEYNSQIVDKLHTVLRPFILRRLKCEVEKQMPLKLERVIFCPLARIQRNMYNQFIRQKETIDTLRGGSAISVMNIVMQLRKCCNHPNLFYPITCTAPTALPKLSLPYPNIINEIEEKDETTILLRLLKSDFIDENNNLLPLIASMFFQPKEKELFQRSVYPKSGLEKFKLTKVKTIKKYDFDEPSKKMQWLWNITKSVRDEIYGRHDALEINLYEPVERHFNNIHCKFVRKYSFPTSPVYAFYPSCSLLPSNNPIQEIVCDKILEDEDPLVSDIHYAGLIQYPDPKLVELDCGKLRMLAKLLRELKQGGHRCLIFTQMSKMLDILEVFLSHQKYPYFRLDGSTQIQQRQVLMDRFNADPRVFAFILSTRSGGIGMNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVVIYRLISSHTIEENILKKATHKRRLGEMALDEGDFNSKFVEKNNVRELFEGEEALKGIIDNCEVSLNVKDMEKVMYNVEDAADVAAAQELKKEIGDEEETEAAPEDFKEAILSQLPPVQRRAFITYLDEQMPEINERLKREFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN74</accession>
    <name>A0A914YN74_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YN74"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2321.t1">
        <property type="protein sequence ID" value="PSU_v2.g2321.t1"/>
        <property type="gene ID" value="PSU_v2.g2321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="123"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2321.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47123" checksum="BAFBBB9570D1715E" modified="2023-02-22" version="1">MSFHRAESIFGKCENAPSLVSAVQFHGVEKTKHDAIVKEINEIYNSKNVDEIIKMSNLAAKHMLDVGLFEGVTPLIDGDPQAKDNYIVNFVVKEPTAVSLGAKIGMTTQGDADACLTGGKQSFNGRGESIDASYSKTIRGGNSFNLSINKPFLGWQRYTSIGASLYQTYESLRWNKAEFGENGLILRYNGQIFNNKVKHSLKFNNLWRTFYPSTNCPFAVREHAGHSTKFSIENSVGVDARDRPILPSKGYYANLTQEHAGLIGDAAFMRHQIDLQAAAPFLLGSFVSATLQCNLVQPMAGKTLHLLDRAYLGGPHDIRGFDIRSIGPQSKKASLGGGASFAVAAHIYRPLKPADMVYLHGFMSAGTVSSLRSTSWTKDIIETPRVSAGLGIAVVFKNLVRFELNYVVPLRYTSNDSIAPGIQFGAGLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP00</accession>
    <name>A0A914YP00_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP00"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19081.t1">
        <property type="protein sequence ID" value="PSU_v2.g19081.t1"/>
        <property type="gene ID" value="PSU_v2.g19081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19081.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10590" checksum="C5E815DB63787C90" modified="2023-02-22" version="1">MPFELSTSQTPQHQIPEYSSVLNKDKELFWPAGGFCCPDGSNYGVCYTISGPGDCLSFHVSSWKNLEHTNAQKYMDAIVESLNEIKNMVERVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP49</accession>
    <name>A0A914YP49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP49"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21412.t1">
        <property type="protein sequence ID" value="PSU_v2.g21412.t1"/>
        <property type="gene ID" value="PSU_v2.g21412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21412.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17443" checksum="6AE1D4FC8D9AE7D4" modified="2023-02-22" version="1">MDINYEYISEANPRLPFRWLPLEALLPTSSQYKTFTFKGDIWSFGILIWEMFERGQELYDGINLPALIRFLKVGHRLPQPQYCPLELYKTMLSCWDEKPENRPDFDALQIEIRDIFRKIKIYESNKLNVAIELNIYGNEYERPNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQA6</accession>
    <name>A0A914YQA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Basement membrane-specific heparan sulfate proteoglycan core protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQA6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2362.t1">
        <property type="protein sequence ID" value="PSU_v2.g2362.t1"/>
        <property type="gene ID" value="PSU_v2.g2362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000552">
        <property type="entry name" value="Basement membrane proteoglycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000454">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF444">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin IV type A" evidence="13">
        <location>
            <begin position="148"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="354"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="410"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="460"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="538"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2362.t1"/>
        </source>
    </evidence>
    <sequence length="581" mass="64585" checksum="02EE29764A6157ED" modified="2023-02-22" version="1">MKYMDLGDVSWEIAVDRDTQEGLALEVEQCTCPPGYVGLSCEDCAPGYERSGHGPYLGTCVPVRQTPPPARTCPPGAISPVAGYDGRCQCKPNLSGPNCDQCAASTFNYAPQSQQGCLKCFCSGVTNQCRSSSYRRTTVDIDYRRGDQDQLEIGTSDARNSFTPQTRPEIYSQAINFGAFEEARGQTLYWKLPQKFLGDKITAYGGKLSYTLRYTGQGTSNRDADVIIKGNEITLQHRARIQLIPDRENVIDVPIMESEWERSDGQPTTREHLLMALADLDSVLIKLSYNDDCSLSSLVAVSLEHAEPYGQGSQASDVEQCDCPPGYVGTSCEDCAPGYRRTGGGLYLGLCERCECNNHADKCDEEYGHCLNCQHNTEGDQCERCRPGFEGDARRGTPHDCRAAATKPPCDCNNHSPRGCDSYGRCLLCEHSTEGYHCESCKKGYYGNATQGTPYDCSPCPCPGTSDCYLGSDGQVKCRNCPAGFSGDRCDKCAPGYTLSARTGGRDCEPIGRVEPDRIQFVDNPQGLSSSDPYAAQREQYRQRQQQYQQQQQQQQQQQLQHRRHRRRRYRVTASRRFHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR52</accession>
    <name>A0A914YR52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2657.t1">
        <property type="protein sequence ID" value="PSU_v2.g2657.t1"/>
        <property type="gene ID" value="PSU_v2.g2657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035291">
        <property type="entry name" value="DUF5354"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17305">
        <property type="entry name" value="DUF5354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2657.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18465" checksum="CC265B8E30110022" modified="2023-02-22" version="1">MNSVVNSICRPIAIIFVIFAISFQKTFALTCYDNTEGEMQLISNDEWTFCTLVPDSNVNSIEAGKVSGLSPSNDDIAPYMLAFGNSDDKYQVLSLCIYERYDFRAFNPKFHVPELLFRCVCNYDKCNARTTFDNYLHNLASKPELAAAASSKTAAAAAAAASASTSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSC3</accession>
    <name>A0A914YSC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sphingomyelin phosphodiesterase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2552.t1">
        <property type="protein sequence ID" value="PSU_v2.g2552.t1"/>
        <property type="gene ID" value="PSU_v2.g2552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF57">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2552.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="16068" checksum="48D04F5B8BF09521" modified="2023-02-22" version="1">MLFGHHHTDTFHILKDDQGNPVQVMLMAPSVTPWFSDLPGAGSNNPAFRVIDYNPTTWDYNEIDTYYVNLTQLNLNHTTPWQLEYSMKKDYNLEKIDAISMNKLFENMKINDTVFMKYIQYNSVLWDPKRPEGKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSU9</accession>
    <name>A0A914YSU9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Headcase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSU9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3770.t1">
        <property type="protein sequence ID" value="PSU_v2.g3770.t1"/>
        <property type="gene ID" value="PSU_v2.g3770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026066">
        <property type="entry name" value="Headcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054537">
        <property type="entry name" value="HECA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425">
        <property type="entry name" value="HEADCASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425:SF3">
        <property type="entry name" value="HEADCASE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15353">
        <property type="entry name" value="HECA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Headcase N-terminal" evidence="1">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3770.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12883" checksum="A718816226B2286F" modified="2023-02-22" version="1">MREKKFIKEELKQVKKQKQNIDAKSKEEEGIVRDRNGEIMCCIPFMKCTRVGHPLPESMNEGVKMCCTNSECAYAKRLVHIECFRSLEQNLMTLVSSKGKNFFDFNIFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSZ3</accession>
    <name>A0A914YSZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3813.t1">
        <property type="protein sequence ID" value="PSU_v2.g3813.t1"/>
        <property type="gene ID" value="PSU_v2.g3813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3813.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26606" checksum="9091986D15E60BAC" modified="2023-02-22" version="1">MSDLRKRIIIIGAGPTAIGSLTRICELMDDKTIEPLDITIFERSSHPGGLASTVTDSHGFSWDLGVHITGATRYPAFLKTLQSAVPEWHCIERCVKADMTHVIHASNPQDNYVPYPVQSSVPYFPDEIKQKCLNELNARFSTEQPKEFTNFDEFSLYFFGKTLQDLFIRPYNQKVWTVPLEEMNCKWVKGRVPKVDVESIQQRSTLSLPELREYDSKSGISFFRQVLSFIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT70</accession>
    <name>A0A914YT70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YT70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3359.t1">
        <property type="protein sequence ID" value="PSU_v2.g3359.t1"/>
        <property type="gene ID" value="PSU_v2.g3359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3359.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="50179" checksum="B9ADD220F12940D9" modified="2023-02-22" version="1">MSLRGGSGNSSNRGRRGEANSNNVGGPRTFETKGGNFRYKGGGTYSDGIKAKTTLSSTPTILSNAKDIGPIKILQSRRNEDAETKPAVPTILQSTAPSIVPRLAVRPKTENEEKHSQPSGLPPTMPASIRFFDDGNNLNKTFLDFLTSTNCNYNCCAIIGPQSSGKSTFASMFSGNETGDLYGEYIFRPSPREFVEKGASQTTSINVYVTKNRTIVFDCQALNSGHIFELAHRSSRREGIKLSQVVKYFEDETHKLLMILFEICHTIILGIDWFIDLNVIRQILSADLSYRKLKSNFNTSSARKINLVVAQLRSKSVDFEPETVAERVKMIRGIFDGTRFDVCGGLSMKKLGFDMYSYVDTTVNYVIFAEIKPRSKLDQTPTTEEYSGLLTIPFHEVIKKFCLNILLLPRPSFHQQTGKLTEREWFQQIATPSWEKLFSSELTSFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU80</accession>
    <name>A0A914YU80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3547.t1">
        <property type="protein sequence ID" value="PSU_v2.g3547.t1"/>
        <property type="gene ID" value="PSU_v2.g3547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3547.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12300" checksum="A87F4B5DA39D2014" modified="2023-02-22" version="1">MKSEWERGHSASVSRGEASAAQLFCRVGKDLLNRIVLSYLDEKMFSAGKELEYDFQEFEGEAGLMDEIGMDDEEEDESFYSSVFVFCRDIREMIRHLRERALKSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV95</accession>
    <name>A0A914YV95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV95"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4064.t1">
        <property type="protein sequence ID" value="PSU_v2.g4064.t1"/>
        <property type="gene ID" value="PSU_v2.g4064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4064.t1"/>
        </source>
    </evidence>
    <sequence length="737" mass="77449" checksum="48EB65FF60F3D6EA" modified="2023-02-22" version="1">MVEGEGATTAKSESTTRNLVEKVIAKMDEISNKTEVTTESPSEAEATTTPQILAEEVTTKSPELTNSKVVHEITSSSTTTGGQGPSESSTTVAPEITTPQTAKETTLVIESETTTIASETTNEVAKSLDESTTVQVQITSEASETNAETTIASSESTEGVTVAAIAEIPTAQTTQMEETDILTTIQPKVIVASVTAAASEAANESSSSTTDNKVSGDETTTIQSATDQSTTETATKGAIVLETTLKTETTESPATVISTTDESKTTISEVTEGETTDESIKTTTDIIDKAVSKVQDLAEKAGELLKKEKEEASTTQASVIEQTSASTFEASTLSDVEGTTIQTVETTIKDVKIIPVEDSKVTTSVTSVEEIQSTTVAQDETTTSSKIAEATEQPAVTAAAATDSANEQTTIQSISADESTTTNVIETTVEAKVTTPKAATTIISENNDLTTTEATTVAQLEDSTTIESVVVVGEKENIVTSTQSATETVTDVKSTVILDTTETSQTTIVEKEDTQKTSVPVVIVAASTTELPTTSTTSEVLESTTKILEATEVKATTELPQEQTDKVSTNVNGETTTLFVPPLENSETNVPVAPLGENEVVLASTEFPTTIILQTTIINDETEQTASTTRVSETTTGTSEDITTASPEIITTVSQPSTVKQDIVPVIVPIGEKQTTISEEQTTSIPVTAENSDASTTVAEETKASEATTIETNQLLSKQKQVKLLKVKQRFQQQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVD8</accession>
    <name>A0A914YVD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21477.t1">
        <property type="protein sequence ID" value="PSU_v2.g21477.t1"/>
        <property type="gene ID" value="PSU_v2.g21477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037297115" evidence="1">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21477.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12180" checksum="61CEBED1C49C85A4" modified="2023-02-22" version="1">MMSHSHTILAIIVGFICLEFSMAAIMPDSCKVNPTVFGPNATSCSDVRDSTECRAIFPASTATARDPQCEKPELEEIALECANTCLACCETTHVEMIHYLQFNCTRKCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVP4</accession>
    <name>A0A914YVP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G protein signalling-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3729.t1">
        <property type="protein sequence ID" value="PSU_v2.g3729.t1"/>
        <property type="gene ID" value="PSU_v2.g3729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015212">
        <property type="entry name" value="RGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09128">
        <property type="entry name" value="RGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator of G protein signalling-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3729.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17465" checksum="49770F5047F7C6F9" modified="2023-02-22" version="1">MHYIQAADVDSIEDYSGEDETTATPQQQVGMNYDHGPFLSLEELKSRPAHLTSFLFYLITDAYQSATCSVKELRRFAYEIFSTFLIPNAPLVMSNISQSLIQTMDKILKATVNATDQDMDQLKKIFVPARTRALDDINECLADFRQKRQYVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVZ7</accession>
    <name>A0A914YVZ7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g4742.t1">
        <property type="protein sequence ID" value="PSU_v2.g4742.t1"/>
        <property type="gene ID" value="PSU_v2.g4742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF8">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="54"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4742.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31305" checksum="A9E8319701C21F9F" modified="2023-02-22" version="1">MAAAASTLHPEFCVTNIFKQGEFERKIEVRCDKIKSDTCSGFSAVSHSDKAIILSFRGSENYEVSEEIIDALFDPPIPAFDGKGRVLDYFLTAFTDVWSAGMKDDFLSLKNANPGYQLWITGHSLGGAMASIAATTIATSKLFDASEIKLISFGQPRTGDDTYALLVDSIIPYTIRVVHKKDFVPAIPVYLNAIYHHKSEVWFNNDMGVGYAWIECDEDEGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNVMKMKGPNVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW12</accession>
    <name>A0A914YW12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2273.t1">
        <property type="protein sequence ID" value="PSU_v2.g2273.t1"/>
        <property type="gene ID" value="PSU_v2.g2273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF58">
        <property type="entry name" value="PEROXIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2273.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34147" checksum="6DD5886667A57ED5" modified="2023-02-22" version="1">MKFPCIEFERSAAVCGSGETSLIFNQVTYREQVNLITSFIDASNVYGSSEVDALDLRDLFSDHGLLRFDIVSGNQKPYLPFEKDSLMDCRRNRSIDNPIRCFLSGDFRANEQLGLTAMHTLWFREHNRIAGKLLEMNADWDGERIYQETRKIIGAMMQHITYKHWLPLILGQDGYNRWIGDYKGYDSNVNPSMSNEFATAAFRFGHTLINPRLERLGNDFKSIPSGPILLHEAFFAPERMLSEGGIDPLLRGLFASPLKKPLSNQLLNNELTEKLFHRSTDVALDLAAMNIQRDMGTTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWC0</accession>
    <name>A0A914YWC0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWC0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4407.t1">
        <property type="protein sequence ID" value="PSU_v2.g4407.t1"/>
        <property type="gene ID" value="PSU_v2.g4407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4407.t1"/>
        </source>
    </evidence>
    <sequence length="473" mass="53830" checksum="561C82DC1BD90BAA" modified="2023-02-22" version="1">MLRSLSGLVQQTIGRKVVVDFKDESSAEGIIESCDESMNITLTEVKYFKRRLGHTGEPVCLDSFFARGCYIRFVHFEFRDTSNIKSLINRTAKEEEKPRTRRVFGQAKLPNAFGHIKIQKHLSDSLNYYEAIYPRIRSLNSTISPYSMHFSFKAFNQTFILILRESDKIPAASTNFRLVDGFGKDKSDQLLSSFTYYEGFLSDCPHTAVSLTVSKTNVEIMGRIDTDNETFYIEKLLNETVIYRASDVQIDLSAFGPRGHTMYVPECAAKRPFFEDLTRSKRAINRRPVKKNRCEMKLVADYEFYKVIGNGNYYSAANYLINVIERVNKIFTSVDWGINFYGDKLINIGFLIKEIKIYNYPTPKGHYFHFNNEYAQSGSSHFSVNNLIMSFSEEEGSNASCVTILVTAKVMEGVQGQGILGLAHVGNTKATLGICANKPHNDFYSNTAVVTVMKKEGLMITRIFDLVFTHGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWM6</accession>
    <name>A0A914YWM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4056.t1">
        <property type="protein sequence ID" value="PSU_v2.g4056.t1"/>
        <property type="gene ID" value="PSU_v2.g4056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4056.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16793" checksum="0EA877C3517E3845" modified="2023-02-22" version="1">MGCWILTFINYNDNSQDIANYIIDAKQLYANSLMSLYDYGKENFDKDIYQEKEYAVYQNFIVFAQELNRIYKEYPKSVGIVKNIRHNDYVIADPLSNLTWNLFFSATTLTSIGYGTNAPDSLGGRLFCLVYISVGIPLYLITMADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWU3</accession>
    <name>A0A914YWU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GED domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWU3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4121.t1">
        <property type="protein sequence ID" value="PSU_v2.g4121.t1"/>
        <property type="gene ID" value="PSU_v2.g4121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="2">
        <location>
            <begin position="165"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4121.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="30366" checksum="7F5048BA289E27D8" modified="2023-02-22" version="1">MEYPFSLNNFIFYNHHALEQLTKRQTRRLKEPSINFVDIIKAILLEIVDYCTIKIVEEERNRFPRLYKRINKVACDIVNARLQPTKDFVEKVVDMQLNYNNFKHPEFKEELDEETKQKMNPFMEDEDESDEIDSVVSEGYITQRSSPLSANSVQDNFLLDEIKDSIKLQYYVKQYYNIVRNSLQDLLPKAIMMELVNHVKNNIQSELEDLIYALEDVEELTKESEAITNHREQTKEKLEELDHAKTLLQNIAELNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX05</accession>
    <name>A0A914YX05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4496.t1">
        <property type="protein sequence ID" value="PSU_v2.g4496.t1"/>
        <property type="gene ID" value="PSU_v2.g4496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4496.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19580" checksum="3D11CB3B149E4DA7" modified="2023-02-22" version="1">MISPFDNQKFAIPIAASKVNRDSAGNFVPKVQRDLYDRITKAEGIIEAKDEMPSGSTISEMLENIFQRHCGTKVNVQQIIPKCWGGSGGHPDNYILPSAKQIKTKIKGPSELELQIADYLKQKGTKIIFCYEFKYENDSDFPVNSRRYIDVIQTDGCRRFFRNGLEYKLPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX92</accession>
    <name>A0A914YX92_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914YX92"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5131.t1">
        <property type="protein sequence ID" value="PSU_v2.g5131.t1"/>
        <property type="gene ID" value="PSU_v2.g5131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="85"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5131.t1"/>
        </source>
    </evidence>
    <sequence length="568" mass="62878" checksum="39C6B27DE49AF371" modified="2023-02-22" version="1">MASSKVILRGAPSIKNAIRNGSTTFTNLTSEQFMKKPTNEPILDYKKGSTERKALEKALEEYASKTIDVPLVIGKERITRKLEHEQVMPSDHKHVIAKYTWATEDDIKHAIETGLEAREKWHMKTLKERADILLHAADLCAGKYRMALNATTMLGQGKNILQAEIDAACELIDFFRFNAYFALDLEKYQPISTKASKNSMLYRALEGFVAAIAPFNFTAIGGNLASAPALMGNVVLWKPSDTAVLSNYIIYQILEEAGIPPGVISFLPSDGPVFGNTVCDHKHLAAINFTGSVPTFKYIWKRVGENLDKYVSYPKLIGECGGKNFHFIHPSADMDSVAPATIRSTYEYSGQKCSACSRIYLPESQWETFKEKFSAIHKQVKMGDVRDGSIFMSAVIDSKAFARIKKYIDAAKSGTDGAKIILGGKCDDSKGYFVEPTLIQVTNPESKILTEEIFGPVLTAYVYPDSEVESVVRSIKDATPYGLTGAVFSGDKDFLYKARDILRDAVGNLYLNDKSTGSIVGQQPFGGARMSGTNDKAGGPHYALKWSSPQTIKETFEPVREWRYTSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXE3</accession>
    <name>A0A914YXE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4775.t1">
        <property type="protein sequence ID" value="PSU_v2.g4775.t1"/>
        <property type="gene ID" value="PSU_v2.g4775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4775.t1"/>
        </source>
    </evidence>
    <sequence length="1223" mass="140864" checksum="C6389D08809F6E0E" modified="2023-02-22" version="1">MYEKLNKLRNDYYIILILDKLSKDAKLRQQRSEEGSAFISPAIFRRSSVSRPLQKESSSSVSDEVIFVQQITTSNSPKVSPAGSSQAHVSSAAARSSYSTSKPSSSTNNDVSCQTNGRQKSKEKHQQQAASISTSEFQAPMQQTSHSPMEVEIIDISESEALPAQQNGLSLRRSSLQQDTISEPKKKRQNPSASQPTRIEIDHLKSSKESTVKKSSKASLPRNRGFNNILKMSNEFESLLVNRDRGNRIFHGKTLKLPPKWNPKALLPEVEAVDDGYDSSDNIPLPSGKGPCGITSTQQNIALDIHCINRTLRSIDPDQKYKILKSFLDEKTQCTIFFYLHAKEFGSGNESMLARVALQRFVMLLNNALKLYELSTIPDTFYGKKIADPQKEWHIPVENCYSYDAPEYVEFERAGASRKIATFYTEFTKVETNILLDAHLLLQHSKDLSSEKRSKYIKDHTELIFQWLKHIKLRANNKEHIHHNFIVWCDLSLPLKNAYDVLLLMEIIFKPQMTSMSESLQNEFGAEKFSPSQHKRYYQAALKGLNCNDFGLDKFHCRDENLWYTAFVGSFFNDVCDINDDQDELYQPFIAAFRQSIDTTKDMLQEKYGNFQHLFADKKFWDKIIEKKCQKIPRPFDLYKNLATFFLEASQHDPNCFDYTAHLIRPFNPDLKVHMETLAALVKMDAMNKKETHNFIQTIVDDIMAHFYPILRTFNELSTEHSAAVRLFTIYVLKGFLMEWEEYNKWTKEMREGKKYDREGSGLDLELIKEYFGKDFMNLPANIMTAIWERKFHVRFFSSNVPKELRKLLTCPEFKILSAETITKILDFYENIGESNIEVKWFKKNDQESEVELMDSTEEFDESLLEAEKNASMSSFNNSFSMNGDNDVVNGTGSSSDNIDNCRSVQVQSNLPQQPHPITSKFGLQPPRKFRSGRLSQWAFKNAVADFEEKGDGFLMAPINQAQDKNSKKRPKRKSSNNYALKVSFKHPVLKSLEEKFYKDFIELNPEMQSWALHFTSVLEDIISDKSENNSTDAGAKNNSNAKTTVKSLSSTKRVKILSTDTSINSNLHLLSPYPLIAVCCRTNSVIYRFPNECLKTPVSENILERHQLNKSCKIWDYLRGKPTKLNHEIIAFLCDIWKKTVIYSQKCKKAENNKDFIPALTIIRNIQEKKETVSDTLIDKIVGVRFPFDLREQKYLKDFCTMYIDVEALSYKDFKFHFDIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXG6</accession>
    <name>A0A914YXG6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914YXG6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2783.t1">
        <property type="protein sequence ID" value="PSU_v2.g2783.t1"/>
        <property type="gene ID" value="PSU_v2.g2783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056053">
        <property type="entry name" value="DUF7636"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056654">
        <property type="entry name" value="DUF7752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF57">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24642">
        <property type="entry name" value="DUF7636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24934">
        <property type="entry name" value="DUF7752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="14"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="12">
        <location>
            <begin position="483"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7752" evidence="11">
        <location>
            <begin position="685"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7636" evidence="10">
        <location>
            <begin position="835"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2783.t1"/>
        </source>
    </evidence>
    <sequence length="931" mass="105658" checksum="C9E5EDF180E94740" modified="2023-02-22" version="1">MDGMDLFHHASNSGVLSVSTELDKILNWHHENKVASDEPCLEMLLRLSQLKFKGPREEFIEIVKHSAPSAVSLNKPMLNIMDQVSKMQSIESHDRIIKRVNCLLNRHINRIMGSLNNEKDALFSIAEFPKLIFHDRLNDFCLTQEPFFRSLLRAWAKFMLNKLTKKMRISIPPSLGRSMFGIVDETGTLLYSLLQSGTVFIRYTVDCYDKLSQAVADKRIYCGKVLITKNPAIVGGDVRVFEAVDCVALRHLSDVVVFPRYGPRPHPDEMAGSDLDGDEYTVIWGKTLYCHFIRTKRIFLDPDLLIDYNQPAFDYSLGPNKDEIKSLEKEEELQGKMIEFFIEYISQDSIGLLANAHLANSDLYGIDTEHCNNIALKHNAAVDFPKTGIAPPPLRRKWGEDGLPSEIVQRWPDFMGKKQRLSYRSQNLMGELYRAVEDIETVLNNAEAVSQVEGKLELDDAFIIDEGYTIDSQNLDENYAFVEAQYLKYCFELQTLLETYGIRTEGELFSGHFSKVNGKITDSGGDNDDLSLYNTTGVVSQRLEELFVSFRTQFFEYFPGGRNYLESAERVRINFQSAAILGQVCTRPNKQMCDVAVIYYNLAYTNKSTRFLSFAWLVWDILAYVKKQYIIEHNIKLPVDPLGTRLSDHIHAVINSTDIVIRNRVVEIVNMINSGSKEWKLINGYCATHSGLKDLLVFLGLWADKHVLNIDLLKFYALVICLSNGTIFPDIDDFTPWLEPIDFIYKQPASVVDLNGKVGRIGRLMVILLSVLSSNKLQTCNEIEVHLDQSRYHLGKNELVAIRDAALTSYYHLSLTDTKNVLPQESSTDLSFSPIVEGPPCVVEIPASLVQKCLDALRKRAKSFGCIHLASRVVSKYNNQNSRICLVAKGTLQQIRAFYDSIAVSPKDFSSARAQYDDMAAQVYEKLFSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXX7</accession>
    <name>A0A914YXX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXX7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4494.t1">
        <property type="protein sequence ID" value="PSU_v2.g4494.t1"/>
        <property type="gene ID" value="PSU_v2.g4494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4494.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="16979" checksum="2E6D170AA533D638" modified="2023-02-22" version="1">MKEYANRQDVFDDALAQHLTLLFGAVLPALVIDRAFGGALWPVDCAACRAGDGLSVAGEARHSRNRNDTRTDCAGALCLAAAGARRGSRLEPDPARCAGERQSDGHERGAAIPACSVTTGVTGISAQPAGGDGANCSVAGGDPGNCSGGAYRRAVRFAYRTAEGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ50</accession>
    <name>A0A914YZ50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3311.t1">
        <property type="protein sequence ID" value="PSU_v2.g3311.t1"/>
        <property type="gene ID" value="PSU_v2.g3311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3311.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14555" checksum="D3BD86584C931B7B" modified="2023-02-22" version="1">MLGNEGGKSMEISTTDAYQGREDDMIIIVSTRSNNRREDLDESHLDEVGKPAFAATYQPKPKPPTVRLNDLKISEADVEKGQGGSAEVGSEERGNEDEGGKSKKEEDKGEEGKMELYVIRFYEVLKAMVASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZU4</accession>
    <name>A0A914YZU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZU4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6015.t1">
        <property type="protein sequence ID" value="PSU_v2.g6015.t1"/>
        <property type="gene ID" value="PSU_v2.g6015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6015.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33879" checksum="1475B6773DF6321F" modified="2023-02-22" version="1">MNPTSIFKNIEIPLFPFPKTVMNYIFANGKPRHYKKLNKTCKYIFIKYQRNCVDWIHLQEDYVYYDEDPEPKPVFERYKFLTRFEKDFALLPSNLMFSSALELNRATTILYKTLMPKIVICNIGSLTMMRSADFLYDDFKFLTNSGRIQTLNLYDTKIIYPNGDPVEIENILAKVINAWFITLNPVHITQNTMKNLLEIQWGRPILMMLRLTKIDNNYFQPDQFFELLQKIASMSVMKGHDRYIVEFKDPIKTQEFNIILSKMVKEYKEPVPEAEKKEVVKDKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZY4</accession>
    <name>A0A914YZY4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Persulfide dioxygenase ETHE1, mitochondrial</fullName>
            <ecNumber evidence="13">1.13.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sulfur dioxygenase ETHE1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12981"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="EC" id="1.13.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Monomer. Interacts with TST. May interact with RELA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.18" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5660.t1">
        <property type="protein sequence ID" value="PSU_v2.g5660.t1"/>
        <property type="gene ID" value="PSU_v2.g5660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000013">
        <property type="entry name" value="Persulfide dioxygenase ETHE1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5660.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28107" checksum="11C86CFF82456F4E" modified="2023-02-22" version="1">MVAHRVFIFRQLFEPVSCTYSYIVGCSASKKAVIIDPVLEMVERDTKLITQLGLDLVYGINTHIHADHVTATGELKNHFPSMHSVINENADGKADIFVGNNDVICFGNGRLEVRTTPGHTTGCTTFVNHQHRLAFTGDTLLIRGCGRTDFQGGSPKMLYESVHNSIFSLPDDYLIYPGHDYSGQTVTSVGEEKQFNPRLNSGEQHFIDIMKNLKLPHPRMIERAVPANKVCGVYELMDEKLKKEICNKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0C5</accession>
    <name>A0A914Z0C5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0C5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6183.t1">
        <property type="protein sequence ID" value="PSU_v2.g6183.t1"/>
        <property type="gene ID" value="PSU_v2.g6183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6183.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11823" checksum="8D13C2A35A867361" modified="2023-02-22" version="1">MTNIYQQHFLNLNNDFEARNDLKKSKSANNSTLSLHIAAYENSIEDKVDSNSSKSDDLKSKSAKTALIKKWNTSKQGFVDSLSVIQVTLNKAIKFVSHLKFTESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z375</accession>
    <name>A0A914Z375_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z375"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6501.t1">
        <property type="protein sequence ID" value="PSU_v2.g6501.t1"/>
        <property type="gene ID" value="PSU_v2.g6501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="60"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="502"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6501.t1"/>
        </source>
    </evidence>
    <sequence length="604" mass="68589" checksum="687ACA37C15596A1" modified="2023-02-22" version="1">MNNVWEKLLHRNPERPLSIKIKPRDRRCVSEPTDMSYVYGASNVPLLHHTIGERFRMAVTHCSGREVVIFKNEEIRKTYKELYDDSRQLAASLLHLGLEKGDRVGIWGPNYYEWIVTQFATAMAGLVLVNINPAYQSNELRFALHKVEVKALITPPKHKSSNYYRTLCEIIPEMTAAPIGIGKIKSKDLPELKHIILFKPEENKPYKGVWHYSEVIEAAGSLDFKQLDEIEKRIKFDDPVNVQYTSGTTGNPKAATLSHHNLVNNSYFIGHRMGLHKTREIMCLPPPLYHTFGCGMGVLCAINHHQTCIFPSPSFNAEATVKALIEEKATMLYGTPTMFIDILNRPELKEANLIELHGGIIAGAPCPTVLCERLIRELGMSDFVVCYGSTEISPVIAMSYTSDPPEERTKSVGHVMDHCEMAIVDSEGCLVKRGDKGELLARGYSVMRGYFHDEEKTRDSITADRWYHTGDTAYMNENGSVVISGRSKDMIIRGGENIYPTEIEFFLMKHRCVADAQVIGVPDERYGEEICVWIRLKPDCKLTEKELKEYCKGKISHNKIPKYILFKKESEFPLTATGKVMKYELRNISRKELGLDQVQSHFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3U6</accession>
    <name>A0A914Z3U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3U6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7027.t1">
        <property type="protein sequence ID" value="PSU_v2.g7027.t1"/>
        <property type="gene ID" value="PSU_v2.g7027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7027.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13681" checksum="5062C39EC7327351" modified="2023-02-22" version="1">MAEKDFCKFNETLKRQLREMECNKMEWDKCATKIREITQNSTMGTWGAVVIGNENDIIDGRIDWFIASYRSEKCRMFIKNEKNKMLIEVFRTGFLAKSVNEDQVCNSKKKYRNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z467</accession>
    <name>A0A914Z467_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z467"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7142.t1">
        <property type="protein sequence ID" value="PSU_v2.g7142.t1"/>
        <property type="gene ID" value="PSU_v2.g7142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7142.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7474" checksum="CD91800631047D32" modified="2023-02-22" version="1">MTKHITTLRDDIMGMLLSTLENCEIHGKDIPTMAEGPLVSGQVTDVRKTVAYEARLLRALILKIMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5C3</accession>
    <name>A0A914Z5C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5C3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18751.t1">
        <property type="protein sequence ID" value="PSU_v2.g18751.t1"/>
        <property type="gene ID" value="PSU_v2.g18751"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g7161.t1">
        <property type="protein sequence ID" value="PSU_v2.g7161.t1"/>
        <property type="gene ID" value="PSU_v2.g7161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18751.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7161.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7920" checksum="A5B3DFBCC7CC9BB9" modified="2023-02-22" version="1">MHPENEHLTHAWNILIGFLIYEIKDAYLSHIRHVRSNSVPHILEGYRLDFRKGSKSRESFEDDSIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5W8</accession>
    <name>A0A914Z5W8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5W8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7733.t1">
        <property type="protein sequence ID" value="PSU_v2.g7733.t1"/>
        <property type="gene ID" value="PSU_v2.g7733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7733.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28388" checksum="ECD9C3033EA44D11" modified="2023-02-22" version="1">MATDGFNFAVFEENLRELVDRGARFDSLLPLTTFKGMDVFAADYRFHENVNDIDRIFAYPRKWNDQNVLCCEFVYFTIFTNDQLFFIIKAKNMRGLHYLDESNAFKAQREIMNYLLYVERLHRIISVDDLLMSDRLNIYLQTDFDYCYDTAALDQKLLRLLMGAFNGGRNVQHQALRDINALKELEDWPPALKIQLIKGKGKLLEILRNPRQLTQFDWICNYTQGTLWTIILPPVLRFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z649</accession>
    <name>A0A914Z649_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z649"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7419.t1">
        <property type="protein sequence ID" value="PSU_v2.g7419.t1"/>
        <property type="gene ID" value="PSU_v2.g7419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000007">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7419.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14118" checksum="FDF89A37A69A7D88" modified="2023-02-22" version="1">MSHGRNNGKKLMAVRIVKHTFEIIHLLSGENPVQVLVNAVINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAVWLICTGARESAFRNVKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z682</accession>
    <name>A0A914Z682_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z682"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5748.t1">
        <property type="protein sequence ID" value="PSU_v2.g5748.t1"/>
        <property type="gene ID" value="PSU_v2.g5748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="348"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5748.t1"/>
        </source>
    </evidence>
    <sequence length="609" mass="68728" checksum="37678A7AFBFE9086" modified="2023-02-22" version="1">MDEIALNKIIEVAQTDVLNQSNPEPRPPRNPEEELLSWKFRNLPCGKSTTSLKTRILSNNGPCCKTPFEELKPIKLCDMKVPMVHSGGYLVCQIVAKPFSIVGVIPPTPVIGIHTLIKDLNGDVEEATLFNLGYNVDEIDFLPFGTILIIKEPCLQYASQNKAASLRVDSPSDIIFVDPTDFDLLDKIGAKQWYESNLSKDAELWQEKANKFFKKEKYEMALKLYDRAIRCNPELSVLYLNKALTCLRIGAFYKAYETAKLALEKGGDREKALYRMGQAAYGMREWQKAANHFVEVLKEFPKNVTVGGDLKRATARLAEQKYGKYDFKAMLLQSKKQKPQLDVADYVGPIEIANIPGKGRGIVATKNIKEGTLLAVEKAFSSGFSQDFPVSLEPVFLGDLSAQAQMLQVIQTMKNLQNNPQKAEELYGLYAGDEMKQTENVPPGIIDAAKIQQICSLNRWGSGCDNLANVYNLDGQLQEDTENSNLFILPSYFNHSCLANSFRTFYGDVIVIHATEDIKKGDEISIAYLYPLNGYQFRKKRIDSWKFECHCKLCELDASDKNCLIRDRMIEELDEHKKSGSPYSVIIKGETLLSKIRESYVDRKELKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z693</accession>
    <name>A0A914Z693_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STING ER exit protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z693"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8203.t1">
        <property type="protein sequence ID" value="PSU_v2.g8203.t1"/>
        <property type="gene ID" value="PSU_v2.g8203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029704">
        <property type="entry name" value="STEEP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="4">
        <location>
            <begin position="37"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8203.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26220" checksum="1AA4635B7E39D282" modified="2023-02-22" version="1">MAAFINEDPIGLEHVDDDRDKGDLKAIEEQDREEHFVKPLYTYYCTCGNMSMISDTPLNRMPQRKRDQARVVDPKWTIAQTFVDNGDAIYIRREEGLEQQYRKKCKKCGISIFYQHPFNLNVLFILDGALLSSKELGGLTGKNDEEIAKKTIMKKHVKNQGKIGSVTVSTVEEDEDELEAKELAESYTTNARIIENQLKRKGMKRSKLERDLMQNKQESGPKKRGTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6Z4</accession>
    <name>A0A914Z6Z4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6Z4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7668.t1">
        <property type="protein sequence ID" value="PSU_v2.g7668.t1"/>
        <property type="gene ID" value="PSU_v2.g7668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF1">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="289"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7668.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45733" checksum="464D5BC169644312" modified="2023-02-22" version="1">MAATINERPCSSAASSLGDGKPEFIQKIENQIARINAIYLLQKEDGVITISEDRAIRVLLKRDSGQFWPSIVEFLTSVPLSVYYDEDTLSLLVGMVNGTVYEYTIAADFNSIQQNRHWEAHTMGVTGVVSSNSARMIFSCSKDKTIVWHCADTSVKIGSYLVDSLCTTIKFDPESKICFVGDYNGNIYVLRIVGNSGQQISKLSAHTAAITSLAWDSKRGQLYSGGADSLVIAWDIAGQKGNCYELNGHDSKISALVLAENPARLFSVDESGHLVCWDLKAKRIMAPGWHDHDRCELCDVPFFWNVKLCWDRKTVGVRRHHCRTCGHSVCGNCCSHFTTFPAMGFEKKTRICNTCHSKMQQYPDQFDLTPLAVQCELNKGIATMCLHEDTGKLAAVSFDRSIMLWDVSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7R1</accession>
    <name>A0A914Z7R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7R1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8365.t1">
        <property type="protein sequence ID" value="PSU_v2.g8365.t1"/>
        <property type="gene ID" value="PSU_v2.g8365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8365.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18708" checksum="A6D3DDC77B3F3453" modified="2023-02-22" version="1">MREKETYLCHSKNEEYVLGNGCREDFFNNCNIDSDVQDTFKSDYNNLEECGVVEDYNSISDFCLKDYCNHNRMRSCISKVINISPNEPIGPAHKAINITFIQRTTPAPTTSIPTTSIPTIQSPNNPIDNDGSQNGNDDKDSQSNASTNSKILSMLFFGNFVFAYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z824</accession>
    <name>A0A914Z824_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsid protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z824"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8481.t1">
        <property type="protein sequence ID" value="PSU_v2.g8481.t1"/>
        <property type="gene ID" value="PSU_v2.g8481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8481.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21655" checksum="E1D23631BBCC442A" modified="2023-02-22" version="1">MQIFRGSNGAPGFLPQQQPFNNNNNNYNNQFQSPNTIVYGQGNQPQNNQQQQYPQGFNPQDQQIYDQSQAYPYMGVNRLNGNGIVSTGGVIMASDNTGVPLLVNPDYLYNNFRTYQIKVIDASYNPNQFVDYQTFQQRQYYGNFVSLRTQFVNYDYNELHILNAVHFNIDIATYPTRYTVDKIQQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8S0</accession>
    <name>A0A914Z8S0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8S0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6640.t1">
        <property type="protein sequence ID" value="PSU_v2.g6640.t1"/>
        <property type="gene ID" value="PSU_v2.g6640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6640.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32102" checksum="FD79DDA568F6F070" modified="2023-02-22" version="1">MVFKGIIDVGCGVNDSLGCSQALSGVTGVAEYNMEGPPRRSSSRPAANVNCCYDDDKRNELGDIKEYRVNDNSAVMDPAANQDTPERTTDAVIFNNGINMDNDYGDKAVDSFDDVKTNKADDIYEIYVAPHGLVGTDHGFVHIGSLTNDESALQNKEESQPLDEPVVAASQSDRANAILDIHNQARGIVDGAAEVYKKLKSAVSIANADLKSINHVKKTISADLMSGIEVFLTDSPGWFLSVLNERDNSIEALRQRLEQCEDECNNLKLDRQQLQMKLEESASTIGLSSNLWLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAJ1</accession>
    <name>A0A914ZAJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7266.t1">
        <property type="protein sequence ID" value="PSU_v2.g7266.t1"/>
        <property type="gene ID" value="PSU_v2.g7266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7266.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17678" checksum="A46EF5B0D62E7CD7" modified="2023-02-22" version="1">MAKHEIKEGCHPILAKTPQKKTVEPTQEETPSGKTVEPTVEDTTNPSVIKHAPPTVTVLKEPIHPPRPYGLAPRSKSYSKSRKTDSLSGRHDLNMNYMVETPLQTLERQKAAVVNDEMKKFYPPEDKPRRRDLREIVILYCRISAMFRMIEELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBG5</accession>
    <name>A0A914ZBG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBG5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9088.t1">
        <property type="protein sequence ID" value="PSU_v2.g9088.t1"/>
        <property type="gene ID" value="PSU_v2.g9088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF492">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9088.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8887" checksum="96580843DD0C4CE3" modified="2023-02-22" version="1">MIVKLDIDLVARAHQVVQDGYEFFANRKLVTIFSAPHYCGQFDNAAAMMNVDENLVCSFQILRPSTKINRVAASSGLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDQ3</accession>
    <name>A0A914ZDQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8404.t1">
        <property type="protein sequence ID" value="PSU_v2.g8404.t1"/>
        <property type="gene ID" value="PSU_v2.g8404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000005">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8404.t1"/>
        </source>
    </evidence>
    <sequence length="329" mass="35925" checksum="A368EC4765195122" modified="2023-02-22" version="1">MQFSVIKAIPVIKCDAMTFDPMTDILKAGGNAVDSAIATLIGIGVVNPQSSGIGGSCLMTIYDASLKKAFSIDARGTAPSASNSTMFIGKSEDAVLGWKASILPGEIHGFWTAFKQFGSGRISWKDIFEPSIKLARRGFPVSKSLALVLKQKEKDIFGDEHMRNHFVNPKTKNLFEEGEIIKRETLANTLELIGNAEDPVKLFYQDGIIAKTIAKEFKENGGIITAEDLANFKAIVDENPLQSSLALNESDLIMCGPPPPSSFGITSAIVGIMAEFYNGKQDDDGTLNDTKVYHRLIEAQKFAYSYRTKFADPDFSKEALEVSQKMMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZF08</accession>
    <name>A0A914ZF08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZF08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8866.t1">
        <property type="protein sequence ID" value="PSU_v2.g8866.t1"/>
        <property type="gene ID" value="PSU_v2.g8866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8866.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23862" checksum="F965EDE4A46031BF" modified="2023-02-22" version="1">MYNLTKNEQVAYDRVATAFNVNNGNSISSTVLSTDYVSKQKQDDLPTFIVKAIIFDITCLQWKIALERPRTKEDAEFFKYCGMIQNIFEAYPTVTPDELKTGKCYFVQYGGKYFRGIYIASSRDNLYGLFDFADFEVVRPIPFHHIRHFPKRKEICVPFMIVWVYTDNCNVKEMDRVNCTFSNTFEKTCFRNIHQVQLQKIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGZ0</accession>
    <name>A0A914ZGZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BRO1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9556.t1">
        <property type="protein sequence ID" value="PSU_v2.g9556.t1"/>
        <property type="gene ID" value="PSU_v2.g9556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9556.t1"/>
        </source>
    </evidence>
    <sequence length="629" mass="72407" checksum="D74545057EDC5F73" modified="2023-02-22" version="1">MSDACFRDSSVSKKLLEPYRSCLDNFDEGLAAGYVAALAGNLDRLLENSLSEYVPFSKNISETLEHFDDLLKTISSIPMSEFDSGLLHYSIAKFYQCVGDIFSARFASGDFNKDNREMLCIYAAACYIISLQYLEEAKFGSRKTRGSIFLSICEMKISLTYSLNYYNIEIELSELLKDIKLGKKLAHALWTNKESIEKTEKTFLALNKVDYFDYTVIPKFDFQKDFVNNLACIWELHSVDGFLDHLLFIIGYGRVTDYLFLGKVLSNIKLEKGNDNDLTSLIDLFDVFLTLVTFAIDYCQISNYKFGYDYSFRHCLGLPQPDINFISPKIIDHSIIVSVARHGRPPLYITLFWKAIQILGRDSSVQSRKALIEKNFRSEAAFREILSNAVNEVNVKNSIHNFYVISERFHLMLIWYIYNGFGDFEMNYVHHRLASHVEYLEKAISNETLTFNENEVDNAELKGGILSQLFPKKNLFWLVYPSSNNCEYLSPISVQEVIAHYYAYTYGRESPEGKKYWNFLSSDYKTVVLPPVESPEEPEADLPEMSDIPESAKVVHSPYKNEESVKNIPQPSITTPSVPSETFFNIEEKSDINNKKFKKAMIELSQDMEKEREKFQTTTEYSIPWSKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHN2</accession>
    <name>A0A914ZHN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHN2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9812.t1">
        <property type="protein sequence ID" value="PSU_v2.g9812.t1"/>
        <property type="gene ID" value="PSU_v2.g9812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9812.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32116" checksum="3C55D13E129F1CDA" modified="2023-02-22" version="1">MAAVSCYLGVGGAAKGAGVTSVYFAFDGVPGGNINRGGRGGNIPSNDGVTSAYFGVGGGGNAAPTSVYFAVGGAPPAQFGGSSQMYTNSAYTQDTIAERQQLPDYFKDHVVHVRNLNNNNEIYPVQRCSSRSLSNTNTIMERQQLPDLFKDHVVHVRNPENSYVQYGRNASIMSIQDTTADRQQLPDFFKDHIVEVRNPGNEYGQYCGGNVSSMSLQETIADRQRLPDYFKDHVVQVRNPNYNNLYPVERASQSSSNTNTIMERQRLPDYFKDHVVQVRNPTTSSYAFQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHX9</accession>
    <name>A0A914ZHX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9906.t1">
        <property type="protein sequence ID" value="PSU_v2.g9906.t1"/>
        <property type="gene ID" value="PSU_v2.g9906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="149"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9906.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24330" checksum="5EECE4E038E5644B" modified="2023-02-22" version="1">MKKETAEMLLNKNIPGALNISADDQTKQQHQQQQSCPLSSAAADSLPSSNVQNSVASRSRRITPKNSNQHLLINSLGPAESFKVEDALPFNPVETQPLQIQKLFTPGRMFPEELQKMQTRLFTDDFGTPFNLNYRKRGAKRKFFSKISHSVEKRNARERTRVHTVNQAFSILKVHLPNLRANAKRVSKLKILRTAIDYINGLKIYYKMIIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQI9</accession>
    <name>A0A914XQI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XQI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10273.t1">
        <property type="protein sequence ID" value="PSU_v2.g10273.t1"/>
        <property type="gene ID" value="PSU_v2.g10273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10273.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12850" checksum="0E056105843DC6A7" modified="2023-02-22" version="1">MNPTNTLDDIEATRKLAVSFEQSKGAAKEIKMEYKDKPFGMNMVGKGNVCGYCGGLHVKGRNRCPAAEATCNECSKKGHFAKMCRSKEFMNAKSYSQPYSNHRHRNSQNLILSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XR57</accession>
    <name>A0A914XR57_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XR57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10480.t1">
        <property type="protein sequence ID" value="PSU_v2.g10480.t1"/>
        <property type="gene ID" value="PSU_v2.g10480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="111"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10480.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34911" checksum="D073E2276DD8FD2B" modified="2023-02-22" version="1">MSNKQFKVVITEAEPPYNDIKSIANVYQNPNPGTLPRDIFLKESKDADGILCLLRDKIDKEFLDNAKHLKVISTLSVGYDHIDLDECKKRGIKVGNTPDVLTAATAELAVSLTLAVSRRLIEAADAARNGEWKIWTPFWMTGNGIQNSIIGILGLGRIGGTVAKLLEPFAPENIIYHNRKPKNESKYEYVSFEDLLKKSDYLIVCVDVSTINGILFDYNAFKKMKKSATFVNISRGSIVNHDDLYKALSEGEIGAAGLDVTNPEPFPTNHPLFTLKNCVILPHIGSATISTREAMIKLSESNLINGLTGKPIVGPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSS1</accession>
    <name>A0A914XSS1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914XSS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10320.t1">
        <property type="protein sequence ID" value="PSU_v2.g10320.t1"/>
        <property type="gene ID" value="PSU_v2.g10320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072518">
        <property type="term" value="F:Rho-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901888">
        <property type="term" value="P:regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF73">
        <property type="entry name" value="RHO-ASSOCIATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="49"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10320.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17399" checksum="DFA066249EC2AC9E" modified="2023-02-22" version="1">MNYSSNLFFPEDVPISDTAKDLIKRFLSDAKVRLGRDGVQQVKNHSFFKNDKWTFENIRHSTPPYVPSLNGDDDTSHFEDVDQKEANIADGFQIPKAFTGNQLPFIGFTYSNELGPIAALKNSALNGSASENQYPVVPDPHSNGPSHEISEQYAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTP3</accession>
    <name>A0A914XTP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10633.t1">
        <property type="protein sequence ID" value="PSU_v2.g10633.t1"/>
        <property type="gene ID" value="PSU_v2.g10633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10633.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10023" checksum="758FD13760C31AA8" modified="2023-02-22" version="1">MIGIQGLEATRGAKGQPGRNGNRGDPGPKGSRGEPGRPGSNGIPGERGFRGDTGIRGPPGQRGSKGREGGYGPPGPDGGYCACPRREFVRGFSRQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUC7</accession>
    <name>A0A914XUC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10849.t1">
        <property type="protein sequence ID" value="PSU_v2.g10849.t1"/>
        <property type="gene ID" value="PSU_v2.g10849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22945">
        <property type="entry name" value="LEM-3_GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10849.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10619" checksum="4246555BCC88338A" modified="2023-02-22" version="1">MIKQLLQCPNIVLPKPNDQLKKLKEWDRERYEIASTTQCYLLLDSSIIGNGPCSFWTFIRAIIYIGMGIDGRMLDHVKTSMELFLEGTQLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV12</accession>
    <name>A0A914XV12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XV12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11078.t1">
        <property type="protein sequence ID" value="PSU_v2.g11078.t1"/>
        <property type="gene ID" value="PSU_v2.g11078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11078.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="50755" checksum="BF9B598BFE265A1D" modified="2023-02-22" version="1">MPQRPQGRMMYMTAPTSQAQQQQHMQMQQQTQRAMAMNQQQRQQMMPNSQQQQQPQQHYYNIQPPRGMVPSPMKMPPQQLQIKQEGMRTPIHMAPPQMIIRGSAPGGYESVQSQVIIQQQQQPQQHQQQQQQIATGSSSQGFISRVPLNQSQTIQTRLHPTQLIPTSRGIRLIRPGDIDMQGQQYVIRSSAAPQGFSYVPSSSGEQQYHIVQQTSNYVQAQGPGLTTVRAIRQMQTSQPQTPLRMALAQSNQQGNMVIQPGVVVIQSSNGGEGTPVILDQSTGNVVATSSNTPQHVTIATTSTPIQIKQTPQIIQRPTISTVVPPAAQATPPKTTPSKTSSKKHTKKPASKPGPSTQTPTPAPAAPVKTSEPPATVLTPQSKLVQNGHLDSIIGTSRASDSFETSVKNAVNEFAETYAEFLLDELVDAARLRKVTKIENRDAKFVILRESNKEKDSEGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV16</accession>
    <name>A0A914XV16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XV16"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11781.t1">
        <property type="protein sequence ID" value="PSU_v2.g11781.t1"/>
        <property type="gene ID" value="PSU_v2.g11781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="68"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11781.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25068" checksum="1152313AA2E31E7B" modified="2023-02-22" version="1">MEIVNGELKVSKKILSEDYEVPQINPGSVQYILKPGDFIGLSKLSEKENDEIQKICGKSDSDSRQFKVAMGTRALPGQFPWVVALGDEQAYCTGTIISSRHIITAAHCVSEYSYKFLPCRDATISLDPSKLKISYGGVCLRYDKDWCLEGRDMKSAKVRKVMLPKHFNDNGCENGGDIAILELDQDLEFNEKTKPICIGHFSSTFEGQLFDLGFGRDEGMWSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWJ1</accession>
    <name>A0A914XWJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10139.t1">
        <property type="protein sequence ID" value="PSU_v2.g10139.t1"/>
        <property type="gene ID" value="PSU_v2.g10139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037528575" evidence="3">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10139.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38136" checksum="12E4FD2C1C2BEF87" modified="2023-02-22" version="1">MILFLFCFLQILINLEGAPLQSQRKIRCQVGYYGNDCSHRCNPLCQKCEEDADNCSECKPGNFLTLRHRSGNYYCKDDCNTDESRIDGKLFYACSSIDGYDNNDNNKRCNDGSYLNSKKICKLCDSLCGTCVGPEIDECTSCKMNEFQVSEKRNRGTFECSKSCEKSSSSTIPGKNYRFCRDSSKESSADVSDINDHLQRLNESSNGSGGFHFDWLHILCIILISNLAVAIAAFLYFKFRNKKEHFTLHSTQYEMAQTEPEEEIQIVTKDQINFGETKKLLGRGAFGKVYKCTFTDPEGRAIHAAVKVIDPIYRDADIETERRVCFIACFEEFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWK2</accession>
    <name>A0A914XWK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10911.t1">
        <property type="protein sequence ID" value="PSU_v2.g10911.t1"/>
        <property type="gene ID" value="PSU_v2.g10911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10911.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17186" checksum="3EF13182E852D465" modified="2023-02-22" version="1">MDGEHGLKMIRKNIDINKLLCKLWITDALYVIPANVTNNSVASSIIPKIYQRDFKRLYLSDQLFSLNEFLFLCSSVKDLTLKEVTVKNGDSNVIPLAKLVEKLPNVKRINYIFTTPSNNTSKNTFKQLWKIPNLSNYNYFGLGMFLGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX90</accession>
    <name>A0A914XX90_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="12">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 19 12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914XX90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10364.t1">
        <property type="protein sequence ID" value="PSU_v2.g10364.t1"/>
        <property type="gene ID" value="PSU_v2.g10364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09935">
        <property type="entry name" value="SH2_ABL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11850">
        <property type="entry name" value="SH3_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000010">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000004">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035837">
        <property type="entry name" value="ABL_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="94"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="211"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="501"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="646"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="790"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="851"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="968"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1049"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="853"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1009"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1058"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10364.t1"/>
        </source>
    </evidence>
    <sequence length="1072" mass="119331" checksum="E78A452E0E6DC2FA" modified="2023-02-22" version="1">MPSFTPGSTDLEPSVSNFPNQIFIALYDFHGVGDDQLSLRKGDQIRVLGHNKTKEWCEAQLIATKRGHIPKLSLIGWVPSLYIAPLNSLEKHSWYHGKVSRNESEILLSSGINGSFLVRESETSIGQFSISVRHDGRVYHYRINVDHTDKLFITQDSKFKSLNELIHHHSTYADGLICNLLYPAPKKQRLPGIFSLSPTQPDEWEIDRHEIVMQNKLGGGQYGDVFSAFWKTHDRTVAVKTLKEEAMALPDFLAEAAVMKDLHHENLIQLLGEYMSKGNLLEYLRKADRTKVPPNTLMFMATQIASGMAYLESRNFIHRDLAARNILVGENHAVKVADFGLARFMKDDTYTAHAGAKFPIKWTSPEGLAYNTFSTKSDVWSFGILMWEVCTYGMAPYPGVELNSVYGLLERGFRMDSPSGCPAAVYRLMLQDIHSNLQTLLQSGVINEEVDRQLEKTRSHSSTNRRSLSSNNGGALANAAAAAAAERRSVGSPRISTSAHRIFEENQQQQNRRLSSGGENGKKISPPQLEFPPPPPPRTSRGYKPTVTDGVSSFRPAESSPSPPQIQRSYRRRSDNHHQQHPPPAVPPASLKPKILKPTIEEDESSSHERMPSLAESHLRRAVNKFGTMDKGQRIEAFLDSIEKSSGFHEPFSDDLCHPSSSSSPPGEGNDSDGASSANQLRLALSPKKQLQRGVSDDSLDTIPLPPSSSAPNSGGRERNYEKDEIVNGDYKRNELLLQLKQRLKKTDNNNTRSMDTVSAVSPASIRKISVHGSAENIALIKNMPAAVIGKRPEPKPRRMDNEAQTEKDWKKNVIRTNSNGKSPEITPTESEQETNGESELQARIRQLRHVQTLSSSTESEEAATVTPTTERRTSLGSNNGKEEFNESQPKNGVTLRTAKKEINNGITTSAEKPRQLITQKVAPLQHHRPFSMQSSNIERSPPILHKSQPSESAEICPTISMQTLERHRQEQLQPRPFSTLQRQMQRQKDEITLNSEAKQPRKFAPTVSNIPSRPSPISSSPGSAGEEDESTAAAMIRAQSLKDLTTKFEKLGGRPNPLSSNATNRTYPRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXP5</accession>
    <name>A0A914XXP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXP5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1173.t1">
        <property type="protein sequence ID" value="PSU_v2.g1173.t1"/>
        <property type="gene ID" value="PSU_v2.g1173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036757938" evidence="1">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1173.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16195" checksum="62B503D9FD9D6BFB" modified="2023-02-22" version="1">MQLFCLIVLALVITFVNGRAAPIQSQECTFTKSKQHSCLYFVIREDKDHAEAADYCFSEFNGGLPGIYESYEEAEEVMKRYFWWSKSNMSIPRFRFGATRRYPRLPYIYDYTYYNPLDHDGVAVDMDICIDFLTFVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYX2</accession>
    <name>A0A914XYX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYX2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12411.t1">
        <property type="protein sequence ID" value="PSU_v2.g12411.t1"/>
        <property type="gene ID" value="PSU_v2.g12411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12411.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13682" checksum="79D00B08C8596892" modified="2023-02-22" version="1">MKLIHWLHATPSNKYETDHVSSSGILKELGIKGWVQYLNLLGYPCKHRELLQPTILAPLQSPLKDVNRDTDRGNSSTLGKTNYGGLSNSRGRNANRGFKRSWSNADDPSNRPNRRRQREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZJ2</accession>
    <name>A0A914XZJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZJ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13378.t1">
        <property type="protein sequence ID" value="PSU_v2.g13378.t1"/>
        <property type="gene ID" value="PSU_v2.g13378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF5">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13378.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15446" checksum="A8E200D665521911" modified="2023-02-22" version="1">MTLNNPDYCTLEQSAVLGIGNARSLAEIFNRAIFEKQLFKDSETLKKLTTPFIKKEDIVTGAVVARGQGLMFSPFIHSSTGKCCQMIGHAGYGGQNIKFDLENELCFGYISNGLKSGFGDSARTFVRLRDSIYSCILSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y110</accession>
    <name>A0A914Y110_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y110"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12470.t1">
        <property type="protein sequence ID" value="PSU_v2.g12470.t1"/>
        <property type="gene ID" value="PSU_v2.g12470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072702">
        <property type="term" value="P:response to methyl methanesulfonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="9">
        <location>
            <begin position="128"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12470.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29154" checksum="C1FB4033E8C1487A" modified="2023-02-22" version="1">MFEAQLEKASTLKKIIDSIKDLINEAPFDCSENAICLQAMDSSHVALVSLKLSIELFEAYRCDRTVSLGLNLTNVAKALKCANNDDVCILRYTDHDQDNVTFAFHDTGKTKTQEITIKLMDIDNEHLGIPDQKYAATIEMSSSEFAKTCRDISQFTDSVTIAAVKGGITFSGKGDTGSNIVTYNGETDAENTDALITFEINENVTSTFSIKYMLMFAKAAGLSERVRLSLSEGVPVVVEFKINEDAGYLRYYLAPKIDEDADMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y115</accession>
    <name>A0A914Y115_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Spectrin beta chain</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y115"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12476.t1">
        <property type="protein sequence ID" value="PSU_v2.g12476.t1"/>
        <property type="gene ID" value="PSU_v2.g12476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12476.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31588" checksum="DFB268F02003D7EF" modified="2023-02-22" version="1">MCEGRKSRLQETSDLFKFMNMVRDLLLWMDEVKREMTSHERPRDVSGVELLMNNHQSLKAEIDTREENFHACITLGRNLLDARHYASAEIEKKLIKLTTERAEMMHRWEDRWEYLRLILEVYQFARDAAVADAWLSAQEPYLASRNFGRNLEEVIALIKKHEAFEKSAVAQEERFLALEKLTNFELKDRQRRPHGISGEREAMSPARPSGHSTAPGRSGETSFPSSEPGRSGEGWWFLNISFFRCKSKNFKHYYFWVTVLFFLISITIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1K5</accession>
    <name>A0A914Y1K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1K5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14073.t1">
        <property type="protein sequence ID" value="PSU_v2.g14073.t1"/>
        <property type="gene ID" value="PSU_v2.g14073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF181">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14073.t1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60215" checksum="75073FDA37B68CC2" modified="2023-02-22" version="1">MVETFSDAAVSITVTSLTDLISFGVGCMTPFPSVQMFCAYAVVAVIFTYIYQLTFFAGIMVITSKREVEGRNCITFQKIAKKKKSTKPASEVIQAPRLWSGGDYYGTATMQRSQKKVDKSFEKNHCLSKFFRTTYADFILNPFVRLIIICGFLFYLAVATYGCSKVQLGLEPNDLLPDNSYGKRTLRMAEKYFSDYGSYLHVWMHNLSKADLGHRRLWVVLEREIELYEHTEFTGTSDSWLRTFLDYINKAGLYITEENFVYILRHVFLSQPQYAKYNRDVVFDTSGSILEASRVPVHLRFVGSANQSRAMHLFRRLAETSDLQTGVYADFFQFAEQYNAVLPGTLSSIAIAGAAVVVVSLAFIPVPTASLWVSFSIVSINVGILGFMTFWSVRLDFISMVTIVMSIGFCVDFAAHLAYNFAKGKNLTASDRIRNALYAVGTPILQSASSTILGVSFMAFTESYIFRSFLKTIILVIVLGALHGLVVLPVLLTIFHCGDSEIDDDTSSSKNSTQTNEGILVVMAGDENQMFVSIHYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2C7</accession>
    <name>A0A914Y2C7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2C7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13606.t1">
        <property type="protein sequence ID" value="PSU_v2.g13606.t1"/>
        <property type="gene ID" value="PSU_v2.g13606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13606.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="12338" checksum="C8B4172C790C2D31" modified="2023-02-22" version="1">MKEKSDNCVEIIEFNPEIVEKMIEFCESDDIKEYENCEEDLFKIAHKYEILVLMEFAVEKMAESLSFSNIEARLQIANLYDLKEFKKWCMQFVFRNNIEIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2M2</accession>
    <name>A0A914Y2M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2M2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13697.t1">
        <property type="protein sequence ID" value="PSU_v2.g13697.t1"/>
        <property type="gene ID" value="PSU_v2.g13697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13697.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19289" checksum="4944198D44DA933F" modified="2023-02-22" version="1">MKLRKENLKLKRGDNVNPYAERLKKAREGKRIKREQEVMDIQGAQNFISITSEFNSDTRNTGVAVVEIGAGENDAVAYGRCEEDPEVIPFLPRKNVKCIKKRSMFHRIRRLREMAREMTGGVATVNSPNQRQKLPLDKQAELLFSKKLTSRQLNHFSKVTGKKPHEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4U4</accession>
    <name>A0A914Y4U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4U4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15220.t1">
        <property type="protein sequence ID" value="PSU_v2.g15220.t1"/>
        <property type="gene ID" value="PSU_v2.g15220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15220.t1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33605" checksum="AB1C9CDF35CC2393" modified="2023-02-22" version="1">MFVLEQEEYQREGIQWTFIDFGLDLAACIELIERPMGIIAMLDEECIVPKASDATLAQKLIEQHLGKHPNFEKPKPPKGKQAEAHFAMKHYAGTVRYNCTNWLEKNKDPVNDTVVTAFKASKENELLVEIWQDFQTQEEAIVAASKSGASKKKGKGGSFMTVSMMYRESLNKLMTMLNATHPHFIRCIIPNEKKQSGVLDAALVLNQLTCNGVLEGIRICRKGFPNRTLHPDFVQRYAILAADESKSAGEPMAIAEKMLARLVRQKNLTEENFRVGKTKVFFKAGIVAQLEDQRGELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5T2</accession>
    <name>A0A914Y5T2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5T2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13032.t1">
        <property type="protein sequence ID" value="PSU_v2.g13032.t1"/>
        <property type="gene ID" value="PSU_v2.g13032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13032.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25135" checksum="D5E0EE9E434F3BA5" modified="2023-02-22" version="1">MEYEVTQEELDTAPTYVDWRQKKVVTSIKDQDSCGSCWAFASTAAIESQYAIHTRKLLNLSEQQLVDCEWVSQGCNYGFINTAYDYVRDNGQFTYDSYPYQDEKTKCHKSNSDRVFIDGHRFVTPNETAIAAYIAKYGPAAFAIICPEALMHYKGGVLEVNDCLEQSTGLHAMVLIGYTQDYWIIKNQWGKTWGENGFVRFKRGINMCDMALQVDAPYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y658</accession>
    <name>A0A914Y658_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y658"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1568.t1">
        <property type="protein sequence ID" value="PSU_v2.g1568.t1"/>
        <property type="gene ID" value="PSU_v2.g1568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037034334" evidence="1">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1568.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9823" checksum="938DDDDA3BC5B579" modified="2023-02-22" version="1">MMTSKIVAAFLILTFGSNFASVNSLHFPGFINGKPLRNYLDKFRIPNNAAAAGDCAAESMFSQIVDHFNPNNTDKWDQGVSIAEQVKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6T7</accession>
    <name>A0A914Y6T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6T7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15161.t1">
        <property type="protein sequence ID" value="PSU_v2.g15161.t1"/>
        <property type="gene ID" value="PSU_v2.g15161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036811138" evidence="2">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15161.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13053" checksum="803D1A24642A4297" modified="2023-02-22" version="1">MVLCRSTFILFCTISTVYCQFLGQGLYGASPYGANLYGSGLYGGNPLGGAGLYGANPYGAYGSPYGLSGMSGYGLPGQGLGSMYGGFPNNYGYNSFPYLPSSSNSQSQSSAQSSSNSGQNNNVYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8A1</accession>
    <name>A0A914Y8A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF883 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ElaB/YgaM/YqjD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8A1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16426.t1">
        <property type="protein sequence ID" value="PSU_v2.g16426.t1"/>
        <property type="gene ID" value="PSU_v2.g16426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043605">
        <property type="entry name" value="DUF883_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043604">
        <property type="entry name" value="DUF883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010279">
        <property type="entry name" value="YqjD/ElaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35893:SF3">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35893">
        <property type="entry name" value="INNER MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05957">
        <property type="entry name" value="DUF883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19029">
        <property type="entry name" value="DUF883_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF883" evidence="8">
        <location>
            <begin position="246"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="DUF883" evidence="9">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16426.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37049" checksum="E1D2C31C2031F7F0" modified="2023-02-22" version="1">MRDGGQIQLTGSGFLALGADLAFSDVKKQGGDQCQARVQGKASVALAGLPASKPNIDYVMTVRDGRTRFQRDDGRGGLEAVQGSFDLRLLGLFSYEHGGLQEGQTFPRQDFQINLDKRSQSNANVLRIHTGAKTVGAQQSWHQSAHTGHQFPGYGLVLPGCADGDEARKYSERCPVHGGCDATEVNLRLTGLRYTEYLYPENSGLKNFVRRCYGAIHLAIRISSRVLHCKELFMATKKSVENSGDKFIEEVKASLDEAEKLMREAAEATGDKAGELREKALRSLRVTRDSLHDAQEAVVEHSVRAAKATDNYVHDKPWQAIGVAGIVGLMFGMLISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8H3</accession>
    <name>A0A914Y8H3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8H3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16499.t1">
        <property type="protein sequence ID" value="PSU_v2.g16499.t1"/>
        <property type="gene ID" value="PSU_v2.g16499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16499.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16683" checksum="6F83A4D18DC79C79" modified="2023-02-22" version="1">MLLLNFVQDSEAKINELQRRNNDLQFETNKLEIRAGVFNEKQLLADERLNKVRKELEKLQIQIGEMEVLYGKRKKEWDDKYDEMFDNYIDKAETELKKHEQIRKIQKDHDDVMERLIDQHSELVDNVDKFQDDDTTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8J1</accession>
    <name>A0A914Y8J1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8J1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15766.t1">
        <property type="protein sequence ID" value="PSU_v2.g15766.t1"/>
        <property type="gene ID" value="PSU_v2.g15766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15766.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12414" checksum="02769F15258AA221" modified="2023-02-22" version="1">MDDGTCPLPVCSTTIKPIRKRRDVVSYLSSDSAISFDAVSQEIEVLQPGSPSRKPKCSEATKIERYIPEGSVCVSKIAFSLVSVATITVAIITLGIVIYFTIRRVQYSDVPSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8X9</accession>
    <name>A0A914Y8X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8X9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15725.t1">
        <property type="protein sequence ID" value="PSU_v2.g15725.t1"/>
        <property type="gene ID" value="PSU_v2.g15725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15725.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19101" checksum="6D39CD9C423D569F" modified="2023-02-22" version="1">MRFHPPTAWTYPDQNAITALSYFPGQPMTQTEAQLHANGDIESAVLAGLQTLQIPTIGITVTPSYSPPLVSDCIKNQQFQSGTTPAGTQFGYEEGGAITKLITAPTGTGVTYQNCVSRAYAGTATNVVLVMTEFIQQASVKIDGITLSEYQATLLGAKVSQYLMLNSRVDFVEEITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9S1</accession>
    <name>A0A914Y9S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIIa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9S1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16029.t1">
        <property type="protein sequence ID" value="PSU_v2.g16029.t1"/>
        <property type="gene ID" value="PSU_v2.g16029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12100">
        <property type="entry name" value="DD_CABYR_SP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000068">
        <property type="entry name" value="Tubulin glycylase 3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047579">
        <property type="entry name" value="DD_CABYR_SP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699:SF11">
        <property type="entry name" value="IGLOO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699">
        <property type="entry name" value="NEUROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="2">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16029.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26753" checksum="BB5F2201B8871265" modified="2023-02-22" version="1">MAESVMEKYKVPTGLRPLLEALARETLRAQPNDLYQFGQIFFDVLQQHKLQNPSVDVISDPLSYDMFRTELHHKYKTQQASANSRPGSPADLAATKIQAAFRGHVVRKHPEKFGIDAVPFDRRRSHDRLNSMDNKKDLKRHSIGGYSLETTMTSPEDRAATKIQAEIRGFLTRKKMGTIKKENNEAATKIQAHIRGYLTRKHLEEEGLLSPSRSRNSLLSNRSDENLDQTATAAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAW2</accession>
    <name>A0A914YAW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14629.t1">
        <property type="protein sequence ID" value="PSU_v2.g14629.t1"/>
        <property type="gene ID" value="PSU_v2.g14629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14629.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36817" checksum="161847EDD8BB174E" modified="2023-02-22" version="1">MGAGSSTNKGVASRSRYSSWGSSIDEAICGENALCGDYPDDDLEGFPLVSKGPSRRASVVTNPYIEATPRQAPRLRRAFSEGEASVRRAYTTDYSDNSDDPDTDDDYNNNQNGNMIRKSRSAAIMRDDEFDHDDFPNRPFPLPMAPGRYDSELLPKSRAKRRRKKAAPIQGSEFQGRRPFSPSQLSATPKQKLPKKKNRQGRRSGMPRSESNYNNDRRRYSMPETIPVTSHSRRFSAFDGVDDSPMYSEPIKKAKKPKKSKSIPNVTKYDDEDDNDWLADYHLPSQVPSDTYYSTSKKGYNSAPLKPIKPITKTRRYDKEPNYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBH8</accession>
    <name>A0A914YBH8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="3">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase subunit 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YBH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16774.t1">
        <property type="protein sequence ID" value="PSU_v2.g16774.t1"/>
        <property type="gene ID" value="PSU_v2.g16774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037594446" description="NADH-ubiquinone oxidoreductase chain 4" evidence="8">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16774.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13349" checksum="77842011351A00C8" modified="2023-02-22" version="1">MPWFATFAMLFFMANAGLPGTSGFVGEFMVILSAFQRNPWIALGAATTLIIGAAYTLWLYKRIFFGEVANSHVAELKDINGREWLVLGVFAIGVLALDRIQQAAVIPGFDDDHLAAAAIDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCG3</accession>
    <name>A0A914YCG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16991.t1">
        <property type="protein sequence ID" value="PSU_v2.g16991.t1"/>
        <property type="gene ID" value="PSU_v2.g16991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16991.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25617" checksum="F1C96477C5E86626" modified="2023-02-22" version="1">MPPKASRNRDRGTAVKFVVPFFGRPACPKCSQINVVRDYGSVPDCKKHVVNEHDMDFYLCCKYCNFSCEDMKKMNIHIRSCNARDKEEVKNYNNKGPIPKAAKLRRVPNIVTSQPRPESRTSSRSPPQQQNSSSAPRTYQRAPRPVSGSPVGQRTRSRSRSISATAPQQPSRQTSREPSAEIVAQTASPTPQNQQPSLQPIQEEEEVREMNGLQRKLQQYNNQTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCU2</accession>
    <name>A0A914YCU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCU2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16563.t1">
        <property type="protein sequence ID" value="PSU_v2.g16563.t1"/>
        <property type="gene ID" value="PSU_v2.g16563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16563.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9299" checksum="AF42C170C6040AAD" modified="2023-02-22" version="1">MSGYATFTLRFFAQFVTNQRVFAVHQHRLTQFAQLLRTFEELPVVYITEVVVDTAIATGRNEAFEADNAHFIQLMQTVDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE54</accession>
    <name>A0A914YE54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YE54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18531.t1">
        <property type="protein sequence ID" value="PSU_v2.g18531.t1"/>
        <property type="gene ID" value="PSU_v2.g18531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF33">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036850837" evidence="2">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18531.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13380" checksum="89E69589A0D9151E" modified="2023-02-22" version="1">MKVLFFIFLLIPLFKICIAAEDADKIIGDLPGTTFKVNFDQYSGYLNAGNGGKWKFFYWLVESQTGNSSNDPLIVWFTGGPGCSSLGAMYQEMGPFYINSDGKTLFENIYSWNKVLKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF99</accession>
    <name>A0A914YF99_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NWD1/2-like winged helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18970.t1">
        <property type="protein sequence ID" value="PSU_v2.g18970.t1"/>
        <property type="gene ID" value="PSU_v2.g18970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="3">
        <location>
            <begin position="82"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18970.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29498" checksum="0AB55335ACDCED3B" modified="2023-02-22" version="1">MNKLVEHKNQYILVPSLGHELGLEVIQRWLKSIGRTLTNRQYEIVKKALNHCTLPLFVKLVYATVARWKSYSKPQDTILFKSVQQSVHALFDRTESHHGKLLVSHALSYITAARSGLSDSELEDLISLDDKVLDDIYQYHLPPVRRIPPLLWSRIRADLPGYLSERAADGVIVLNWYHEQFRSSAEERYFKNLNHLQNTHSAIADYFLGIWGGVAKPYQYTDLQKQRFGVIENEGLADRKVPKQTNIFWGKDNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFA4</accession>
    <name>A0A914YFA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18976.t1">
        <property type="protein sequence ID" value="PSU_v2.g18976.t1"/>
        <property type="gene ID" value="PSU_v2.g18976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18976.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="16463" checksum="A7F2E7ABDE181000" modified="2023-02-22" version="1">MGLSTIFTSFVQCFKKKPNSKKNKGQQNSQSNDGSNNVTDIGSGGIIIGSAADGSSAGRNNGGGGNGNDGGGGGGGIEKSKRQQSLRTKTAVTPIKKSTNKHGGSDNGKSSGKKNSDEEIIGSDSGPGGGGEKKEGLSKEVIKKSKECGKQKVDDRDVSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFS0</accession>
    <name>A0A914YFS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFS0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18299.t1">
        <property type="protein sequence ID" value="PSU_v2.g18299.t1"/>
        <property type="gene ID" value="PSU_v2.g18299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18299.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="10940" checksum="021FFDE0DDC6EEE8" modified="2023-02-22" version="1">MAPNASDEFSSEAIRNARRQNVGGVATNSRVNAVYTIDAGARVQQPGNNTVYISQGQPVYIIPKAAVDEARAAASSRRNCILCIIITKLIVIAVVVIIIVSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG60</accession>
    <name>A0A914YG60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19287.t1">
        <property type="protein sequence ID" value="PSU_v2.g19287.t1"/>
        <property type="gene ID" value="PSU_v2.g19287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19287.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12567" checksum="187B66C473CEA6C5" modified="2023-02-22" version="1">MTSPRRSPTTSECATTALLRHHRHDHDHEIFSALFKRRYNYYNPFDFIPQNSMGSAGYSSRSAPSINVEGYHFTFENENGGALRKVPCLQSCLTCDDGGYESSSQVRKTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGE0</accession>
    <name>A0A914YGE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGE0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19369.t1">
        <property type="protein sequence ID" value="PSU_v2.g19369.t1"/>
        <property type="gene ID" value="PSU_v2.g19369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037702473" evidence="1">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19369.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16507" checksum="7591D23CA8C5A62F" modified="2023-02-22" version="1">MDFFKIIIIIFALLLGIFGQRFQRHSSNDNSQNNLDVVDNSKKLASDVNTFLITESREYEIELLNGELKFEMCTSVCNNDLLIFCFDSDEPKTVAGSNRCPNQCEVHAGFQQIGADKVAHFSGRTSSYAVTKQCDIVTMQSPATTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHH1</accession>
    <name>A0A914YHH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHH1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18243.t1">
        <property type="protein sequence ID" value="PSU_v2.g18243.t1"/>
        <property type="gene ID" value="PSU_v2.g18243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="114"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18243.t1"/>
        </source>
    </evidence>
    <sequence length="579" mass="67043" checksum="34FC215BBB34C4FD" modified="2023-02-22" version="1">MYSYVSSLVKNKHPPIPVLKSGDQIFIEDQQKAQKFCEYFKSVYNTNTTVSDEQMPYIDGEIILENITFNREMIKEQLKKCSNKNINGPDGIPGIILKKCRNIISLPLTYLFNQMISKGEVPKEFLLSHVTPIPKIPNPKNFNDYRPISGSSDIFKTFERVLKIYILQHLKEINFLPKQQFGFRNGYSTTKQLISYFEFIYLKVSSGETIDVIYFDFVKAFDKIPIQKLISSLKKAGIRGKLLKIITVILSNRKFLVKVNSTFSNLDDATSGVPQGSVLGPIYFIIFIAELSQRLNLHDNIIHLLFADDLKLLYSYSPKNFENSTLQNAITDINDWCKENSMDLSVPKTHHIQFGKPNEAAIYFIDNNQIIKAENVRDLGVFISKNLSFSQHVDRIVSNATKKLFSITKKVITNDRDILIKIFNTYVRPNLEYCSPLFNIPKLKLIKKLESPQKKFTWILYRRIYGFYSKIPSYEERLKLFNMDSLLDRRNVADALIAHDLVLNHQNDNIISLHYNDHGKTRAEGNYNYYGKIKKSFLSYHFSSRMAVKLNNSKIILKDHSTDSIRLKLTTNKKKNLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHQ1</accession>
    <name>A0A914YHQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">U3 small nucleolar RNA-associated protein 20 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHQ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19858.t1">
        <property type="protein sequence ID" value="PSU_v2.g19858.t1"/>
        <property type="gene ID" value="PSU_v2.g19858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19858.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29385" checksum="D6E709D4550CB7EE" modified="2023-02-22" version="1">MEEGSEDEIEQDNSTVIENTAPQDAPRNIRRKKAIDALKTLLETFARFSNPKNIKRESELKDIYNELLKCDQDTLRTAAFYCIVAYRYSFLAPYVDYFAKLLDSKQFREGLVLFSISDENSVVQSGHREELIPYLLKILYGSLSSYVMVRAVARRNAVLTYLRGFQPNELQLFFEIMFGPLLDYIKINEFSTDLEQLCESIVTNYDSSNTLSPKKLKRLVYFIIILHKKPVINILENSKCTVILKTRQNFTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHZ2</accession>
    <name>A0A914YHZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHZ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16935.t1">
        <property type="protein sequence ID" value="PSU_v2.g16935.t1"/>
        <property type="gene ID" value="PSU_v2.g16935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16935.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9603" checksum="ABB39759C37408B6" modified="2023-02-22" version="1">MIEFCENDSVKDLEDSEDELFKIAHLYQIQQLMYFAVEKMAENIKNEKIADYIQLANLYDLHEFKKWCMQYAQRQNFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI65</accession>
    <name>A0A914YI65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4604 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18505.t1">
        <property type="protein sequence ID" value="PSU_v2.g18505.t1"/>
        <property type="gene ID" value="PSU_v2.g18505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040219">
        <property type="entry name" value="KIAA1143-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195:SF2">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18505.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19998" checksum="5EA78AA575203340" modified="2023-02-22" version="1">MSNKQDKPLNYQQRQSIRYVDNGDPPFIQKMKQGMGYRETTVEDKFEPETKQTKDEEKEEDDIRNLKEEDRPQVVVLNEKTDITQSEFDEEVRKKEAENDKKKIEEGKITFIKRTKRINDETVEEAAKDEIPKDKTLRLEAEQKRDDAIKKKQNKNLLSFGEEEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YII9</accession>
    <name>A0A914YII9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YII9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20157.t1">
        <property type="protein sequence ID" value="PSU_v2.g20157.t1"/>
        <property type="gene ID" value="PSU_v2.g20157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20157.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15000" checksum="4A1A9F8407511B81" modified="2023-02-22" version="1">MYKNAMTLLNEAIHYVPSPVPKNNREQVDQQFESMQKWYKFTQRRLDEFKKDDAKDYNNSDAPSFQQKSPGSAKKTGVAALFATKEEQEILGCIILSTNIKLDDVLGNEAAKLALQETNSSKGYFIIWTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIW1</accession>
    <name>A0A914YIW1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIW1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18765.t1">
        <property type="protein sequence ID" value="PSU_v2.g18765.t1"/>
        <property type="gene ID" value="PSU_v2.g18765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="14">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18765.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11341" checksum="47FC384D96524A53" modified="2023-02-22" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENIIRDSVTYCEHAKRKTVTAMDVVYALKRQGKLFSGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJJ2</accession>
    <name>A0A914YJJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P/Homo B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJJ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20505.t1">
        <property type="protein sequence ID" value="PSU_v2.g20505.t1"/>
        <property type="gene ID" value="PSU_v2.g20505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF13">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="P/Homo B" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20505.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10554" checksum="B534F8BFCD953F24" modified="2023-02-22" version="1">MILSRRPKDDDSKDGFTNWPFMTTHTWGENPRGKWRLLVRFQGEGKHRGTLKRFTLMLHGTKEPPYSGIEPLEGHPNSKLNVVQTAHKRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK03</accession>
    <name>A0A914YK03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK03"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19199.t1">
        <property type="protein sequence ID" value="PSU_v2.g19199.t1"/>
        <property type="gene ID" value="PSU_v2.g19199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19199.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="15207" checksum="E642A08BF6EE7A9F" modified="2023-02-22" version="1">MVYAARLQGDAACGGDGAALAIQLPGAQQQALSAGMAERALHVGHVAGVDLQRRTIAGQHAVAVVEQTRYLKLGRGAACRTECAATVGELAGFDVLGTVAGNGARVVGQAAAYLQCQRPAAGCAQRACAVVQAVGHDIELPGRHAAAAEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL52</accession>
    <name>A0A914YL52_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YL52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20268.t1">
        <property type="protein sequence ID" value="PSU_v2.g20268.t1"/>
        <property type="gene ID" value="PSU_v2.g20268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000009">
        <property type="entry name" value="Glycerophosphodiester phosphodiesterase, periplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008354">
        <property type="entry name" value="PRK11143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20268.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25457" checksum="FB0BDC6A8B23D4EA" modified="2023-02-22" version="1">MGKSDFRVHTFEEEIEFVQGLNHSTGKNIGIYPEIKAPWFHHQEGKDIAAKTLEVLKKYGYTGKDDKVYLQCFDADELKRIKNELEPKMGMDLNLVQLIAYTDWNETQQKQPDGSWVNYNYDWMFKPGAMKQVAEYADGIGPDYHMLIEETSQPGNIKLTGMVQDAQQNKLVVHPYTVRSDKLPEYTTDVNQLYDALYNKAGVNGLFTDFPDKAVKFLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLJ0</accession>
    <name>A0A914YLJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase III subunit Rpc25 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLJ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19773.t1">
        <property type="protein sequence ID" value="PSU_v2.g19773.t1"/>
        <property type="gene ID" value="PSU_v2.g19773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="7">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19773.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22520" checksum="32C7C7543FEBB4F1" modified="2023-02-22" version="1">MFVLSDLQHTVKIFPEEMNIKMEDRIIDKLNAMLANKVIKDVGLCLTFYDFIKIDPSYIPQGSPTVYVPVQFRYLVFVLFPGEVIDCFIRKATRDGLYLGVGFYDSIFVPAANLPEGSAFDENEQQWNWNFKNEDQILSYGMETNTETRVLIENITYKDGKVGKNSSVMSVTGTINTPGLGCLSWWQDVEEEQEAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMB0</accession>
    <name>A0A914YMB0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20715.t1">
        <property type="protein sequence ID" value="PSU_v2.g20715.t1"/>
        <property type="gene ID" value="PSU_v2.g20715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Prp18" evidence="8">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20715.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13731" checksum="FF69F850B82880DA" modified="2023-02-22" version="1">MKDVEPLLRALAKGNVNSDQRCHLVNIARIILIDHNYIIANNAYMELAIGNAPWPVGVTRSGIHQRPGSAKAYVNQIAHILNNETQRKYIHGLKRLMSKCQDYYPADPSKCFEFVKKDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YME9</accession>
    <name>A0A914YME9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YME9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21512.t1">
        <property type="protein sequence ID" value="PSU_v2.g21512.t1"/>
        <property type="gene ID" value="PSU_v2.g21512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="129"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="335"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21512.t1"/>
        </source>
    </evidence>
    <sequence length="621" mass="70341" checksum="A45812D414890D51" modified="2023-02-22" version="1">MQNQSKLAIKFLNYYAKENGIEILHRNNSAGGEVKVNNISVDGYEIATSKIFEVNGCRWHACPKCYPRGNTVIFDGKNADEIRGRDAARLKRLNPQGTYEIITFWECEIEEMLRKDKVMKKEFSLMPDDSPINLRSALQGGRCGPMKLALNRIPGQQIIKHFDIVSLYPFICAFFQLPKMHPIIKTKSEPYQRVEDVPFGIIKAKVLPPINQKLPVLGVKKHSMLLFGNCNRCMENYGQPDPKNPARNVGKISCKCTDEQRSLVVTTTSEELKFAMRCGYVVEEVYHSLEYAHTSNKIFLPYIQDFLVLKTHASLPPPSFNTPEGKKNFVDLHKKLYGITIDPDKCAYNPGQRFIAKIFLNSAWGRFSYLANASEKDVINYNEYAELTKDEQIYDLTAIEIEENVLMATYKKDVNLVNASSTSLPISIFVTSYARLWLLRFLRQIEATPGCSVGYLDTDSVLCSCPSDDQVPIVSGDGLGSMMDEHPDEIIVSYKSGGAKNYMCTYRPKDGGRSRIVKKIRGLTATAATERLIGPMDFDYDPAKTIPIPTTNIGPSKDLNLYTTETSKNYRTICLKGIVWDNTVYEFGHRFDEPDYPIILTEDDDTDIERMIQKQNALQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNM8</accession>
    <name>A0A914YNM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20577.t1">
        <property type="protein sequence ID" value="PSU_v2.g20577.t1"/>
        <property type="gene ID" value="PSU_v2.g20577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="164"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20577.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37341" checksum="0DD47EC08CD6CC62" modified="2023-02-22" version="1">MYLNSSKTMLEYPFALEYSVSEDRLKALKDSTNGYLKSDTFIAINSSGVKYYLQIYPNGNNDQYRGKTMIFLQLELGKEKKVEAEYTFSIKTANYTLKFNKTFTENIGRGNSCCTVNELFDSNKKFIVDGKFTVKVEGTLKVEKAETKWESFMNSGELWKIGFQDFTIVVDGEEIKVHKNILAVHSPVFAAMFKPPMKEAAENKVEITDFSFEIVEMAVKLCYHRSLVSDISVKEAILLLRFADKYNMANIQNNLEEYLSDKITVSNVCEIANCAAAVNALKLQNQCLDFLTICFSKKEFVPNMELLEKDFFISVYAKSCCLKSHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNS8</accession>
    <name>A0A914YNS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21075.t1">
        <property type="protein sequence ID" value="PSU_v2.g21075.t1"/>
        <property type="gene ID" value="PSU_v2.g21075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21075.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15850" checksum="688FD89C3786DC54" modified="2023-02-22" version="1">MIPETGLLNQQCDEFSGIVERDKRQYCRYCELCGLSAKVENGLNQGQHKFLPQLAQGQESAFSPHCSKISSDSYEFKRSLNLPGRQELENMIKGKVQGVDNEIKKRLNKGRGRFQVFLNLIAAEQPPISQKAWFEGSEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPC1</accession>
    <name>A0A914YPC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPC1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21279.t1">
        <property type="protein sequence ID" value="PSU_v2.g21279.t1"/>
        <property type="gene ID" value="PSU_v2.g21279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF171">
        <property type="entry name" value="ACID PHOSPHATASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21279.t1"/>
        </source>
    </evidence>
    <sequence length="514" mass="59326" checksum="C86A56C8B846322D" modified="2023-02-22" version="1">MVRRSESSNRARKTVRPTENSGGVARKRIREPSNEGSSRRKKTKPLKNNKAAENERSALQRIRLYGKGDFSIPRAPFFKVIKECLLNLSTGGRPKYKIQRAALDALQIFYVFGELKQVQIFSRHGQRAPTNFLIFPTDNPHFLDNFDAEPGELTVYGIRQEYELGLTLRKQYNLVLGDIYRSRESIFFAGKDNRTIVSALAVLAAIYPPKQKQIWMEGLNWQPIPVHTEELLDDVSFGLFDNCPTISKDIYQMADFKSMLEPLMDKVELLSNLSGIKIDNPRTFDKIIDSIKTRSLMPDLLPPPIWARNPRFLESIKNWSNLLHINLIDLINDKVGGWHFDLMIGKMEEIVRNQTNKKFILYSGHDTNIMAISRFLNLTTIAQRELQIYATYLSVELHQKSTNDFFVEFWLHPALNETRKYIGIPECPTPCSYTNFRKLRNRISTEEWHIKCKGIPRNLDDRCTLYASLAGGLVICVVILIAALLAAGWWCCHYRSKYNEIYVEDDDEDSPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPS1</accession>
    <name>A0A914YPS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21013.t1">
        <property type="protein sequence ID" value="PSU_v2.g21013.t1"/>
        <property type="gene ID" value="PSU_v2.g21013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028226">
        <property type="entry name" value="LIN37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15306">
        <property type="entry name" value="LIN37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21013.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27011" checksum="11A9E6BA6A6BCFD4" modified="2023-02-22" version="1">MKRSSAENEGFLHPDGSVRRLTGTEHFIPVSPDMKNARHRLGNLLSGIRKGDIGTFGDKDDDFDSDQGYSRKGPGRPKRSKRERRIIYELRNKVFSVRDSYTIEPIYPLMRKWIYGCDDDLPPVSDELPASPDDRTLPGSSSMISEDSLDLLATKEIHKMPEPLPLSDDTPLMKIFSPVENPLPEGSAAKDLLKENLTAWKNCKKQHKKYMEMRELKYEPSLKLLKTVHAITQQTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPS2</accession>
    <name>A0A914YPS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2819.t1">
        <property type="protein sequence ID" value="PSU_v2.g2819.t1"/>
        <property type="gene ID" value="PSU_v2.g2819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF54">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2819.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24280" checksum="310C19A9DC6B0C52" modified="2023-02-22" version="1">MSWVTAGCGYPGSILNQPWPLTIPGNKPPIKPWPIPAAGNPTMRVLHLTDIHVDRKYSVGSEADCAKGAIETYNFCCRSQNSSSSAIKMPAGKYGTPARCDIPFIMFEETIKWISTHEPNLDYIIITGDFESHDIWSNQQDTTRVNLFNITDTIYLYFPNTPVFQTTGNHEGVPMDAFAPHSISDYDNRGPQWLYTIFNQTWTKWLPTSVQQTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPV5</accession>
    <name>A0A914YPV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPV5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21053.t1">
        <property type="protein sequence ID" value="PSU_v2.g21053.t1"/>
        <property type="gene ID" value="PSU_v2.g21053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037504927" evidence="1">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21053.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11439" checksum="298490499638C7EC" modified="2023-02-22" version="1">MKGAVYLIVTVFLLICCMQVADSAWTVYYLNPNGNSNNNGYNYNSNSNGYRTYYYPSNNNNNNNNGYRYYNPSNGCSNCGYNSNNNGYPYTTYYYYGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQE5</accession>
    <name>A0A914YQE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3033.t1">
        <property type="protein sequence ID" value="PSU_v2.g3033.t1"/>
        <property type="gene ID" value="PSU_v2.g3033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037985001" evidence="2">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3033.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28155" checksum="C989246E0F40DA45" modified="2023-02-22" version="1">MKQLFSIKCFVFLFSAFFAVSAFVVGNHHPGDDHVRHGHLSHPPRHPGHPPPFVGTLDGNYFKPRNFSVTQLERSKDLQQSELEISNKTRHQNSSSTNAQNELNDDNDDVARNELTDDKPPIPESHGKIELKSLKKKKKKSCKKYKKCCKKGKKKCCKKLKKCCKKSGKCKDSDGKKSDDDDEDRPAKGQRKIPEDKPEIKQPPQLEDEEEEDVDEEEDKTESRAPKSPQNSTQQKETTEDYSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQF9</accession>
    <name>A0A914YQF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQF9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21281.t1">
        <property type="protein sequence ID" value="PSU_v2.g21281.t1"/>
        <property type="gene ID" value="PSU_v2.g21281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21281.t1"/>
        </source>
    </evidence>
    <sequence length="403" mass="44994" checksum="EF0810B92DDA5692" modified="2023-02-22" version="1">MNGNEVVSREKMHIEATLRGEREEAQKILREAEIEISRLQKELHDFRRDNSAMLRNTDERSDELRRLRVAECSQKSTINSLNGTIQQLNHVLSGKEMEIATLRRQVDMLRQYNGDENQSLIKQIELLLVKNQDLHERSLTQKDTFHALQRDLQEQLVMLRRNKEKLEEKIMDQYKSMDSRKIKEKQTLMKRAAKALMPKATTRKAIRAPLPVAINGSTTEDSSIDETHGSFISPTPPVAGASSTSAAAAPPATSTPPTTTMSNGQSSNPSTSHSITTQAKPETDSAVHRFFRRSSLLRRTNPLPRRSNEPTSLSTSAPFNNNNNTNNNNHVSHNSALPPLSPINNQYASLRIKNPTIITSQQLLQSPNGVGCCGIPQRRAPIAAIDDEIGIIKGRPSSAYENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR18</accession>
    <name>A0A914YR18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YR18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21523.t1">
        <property type="protein sequence ID" value="PSU_v2.g21523.t1"/>
        <property type="gene ID" value="PSU_v2.g21523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21523.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23358" checksum="78415574EC9B6DB5" modified="2023-02-22" version="1">MKSAWFLAIEDEVKDANIVLASQSPNRLALLKELGIDPRVIVSGFEENLSKTLPPSQFVEDTAAGKALEVAKILAEKKDPFDIIIACDTVVVIDNEIIGKPKDADDALLILNRLNNRWHSVFSGVTLIDSRQRIEKFHIETNVKFGNIPAEMFQEYIRSGECFNRAGAYGIQHKAAAFVESINGCYSNIVGLPIYEVVKRMRKLLLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR65</accession>
    <name>A0A914YR65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2506.t1">
        <property type="protein sequence ID" value="PSU_v2.g2506.t1"/>
        <property type="gene ID" value="PSU_v2.g2506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2506.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="21014" checksum="035D59B5BC206D1A" modified="2023-02-22" version="1">MELKRFEIFKNQDQENGYFDCTLIIDGKKLFVHKYFLASASEVFSVMLSDQWNKNDELKIENPDYSYENFYHFITFIYSGTCNLDAENIFVLTDMAEFFHVESLKILCDEFLSNMNFDAGNIVQAFEFAQKYSLEKFENSLKNFIRYNYGDILQTEAFLGFKKSFVEFMSTICKYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS20</accession>
    <name>A0A914YS20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2972.t1">
        <property type="protein sequence ID" value="PSU_v2.g2972.t1"/>
        <property type="gene ID" value="PSU_v2.g2972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2972.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8819" checksum="32B81347CA8A1CAC" modified="2023-02-22" version="1">MFFCCKRKPPTPAEPLKRPEEYGSSIISGKDLFFLSVIFYKECLQNEGDINGMGDMVRQLKTPLERIEFVSPYERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT57</accession>
    <name>A0A914YT57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3870.t1">
        <property type="protein sequence ID" value="PSU_v2.g3870.t1"/>
        <property type="gene ID" value="PSU_v2.g3870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038839">
        <property type="entry name" value="Attf-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36522">
        <property type="entry name" value="AT HOOK-CONTAINING PROTEIN ATTF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36522:SF1">
        <property type="entry name" value="AT HOOK-CONTAINING PROTEIN ATTF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3870.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25682" checksum="F976112714CA217E" modified="2023-02-22" version="1">MLASSDDLSAQVKLFESLSNFQASTNNFESSREEGKRGRKSKYCDAATKVDITNYAKQFGPSAAARKFNIPTAVASYYYRKANSPKLLSMKSLSSEIESPKINTADDQIMSQSVSQVPSSSPNTFLRGRGRGRPKLIGDELDAALVDYIVETKKQNPQKHYTAGTIMDLSKDYIKRSAPGLLVEDGGSVNLKNTWAIKLLMRVAEREHELATNSNEVFNRMLIDFFNTAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTY6</accession>
    <name>A0A914YTY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase M12B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20918.t1">
        <property type="protein sequence ID" value="PSU_v2.g20918.t1"/>
        <property type="gene ID" value="PSU_v2.g20918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF291">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="110"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="284"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20918.t1"/>
        </source>
    </evidence>
    <sequence length="469" mass="52838" checksum="596AC70018E63BDB" modified="2023-02-22" version="1">MIENDNNCIFQGQSIKPNSSFTVALTGCGNDMQGIILTETDDYYLLKPPSIHNFFENNNLQKIHTIQKRSANIHQHHSCGFDISSDPYPEDRYHSIIDPKFLAVHKFEELIIELGVFVDDAMWQFFEKFYGNSAEKEVKRFVIAAVNNIDILFTRSTIEPKVRLKINHFEILKTMPMPLTRTYHSSGDVTKMLNSFCTYQSSINPKNDADPNHWDHALLLTGYDLYRDNVKTIAGYAPVKGMCEQIHNKSCTVNEGLDFGAVFVITHEMGHSLGMYHDGESNQCQPRCCIMSPSIGAGKTQWSSCSVNELHTFVSRLGTGDRPSNCLMDDRKLTLQTEKLYLPDKPFPGQDYSLDEQCSLFHGICWKQELQTGQALKDVCSMLWCSNGESVVRNTHPALDGSYCSSGRICFEGKCISAATKSILTSPIHGGWGSWDDASKCSQGCNDCKIEGQLRVKRSVRMCNKPFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU67</accession>
    <name>A0A914YU67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thaumatin-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3200.t1">
        <property type="protein sequence ID" value="PSU_v2.g3200.t1"/>
        <property type="gene ID" value="PSU_v2.g3200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09218">
        <property type="entry name" value="TLP-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000004">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013:SF12">
        <property type="entry name" value="PATHOGENESIS-RELATED PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013">
        <property type="entry name" value="THAUMATIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037551194" evidence="2">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="72"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="83"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="150"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3200.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27424" checksum="70B227E83C88A8C0" modified="2023-02-22" version="1">MFKLIVAFALLFQWVSAVKFTIQNNCGGPIWPGIQGSTLPEGGGFQLAKGASHDIYVPDRWQAGRFWTRTWCQNDYNCGTGFCGNKLQCGGAGGRPPASLAEFTLDGAGNQDFYDISLVDGWNVQVRVEPIAGTFHSNGGPMECKAIGQCNADINSRCPKELQLIDPLFGSGEVIGCYSACTKFNTDYYCCRGAYGTSQTCKSSTWPTNYPKIFKDICPQDYSYAYDDSSSTFTCRGSGGRISPDYKITFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUN2</accession>
    <name>A0A914YUN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUN2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3848.t1">
        <property type="protein sequence ID" value="PSU_v2.g3848.t1"/>
        <property type="gene ID" value="PSU_v2.g3848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3848.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19965" checksum="0D069CA4A73533AC" modified="2023-02-22" version="1">MCYKFTPSNSESFDLFEKKCSCEHGTPRKYKHNGINNRMNNRHKRHLRGFPHQNIRYAAPFQPRPQFVVAPRANNNYANQAARAPQSIPLVDHNTYECIRQPDNCYKYPKPNIPEDNCPPGWIFIRSFGSNCYKFHPAQTWHEAERTCISQNAHLASARVGKEMDVLSEPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUQ1</accession>
    <name>A0A914YUQ1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">UMP-CMP kinase</fullName>
            <ecNumber evidence="12">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Deoxycytidylate kinase</fullName>
            <shortName evidence="12">CK</shortName>
            <shortName evidence="12">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Uridine monophosphate/cytidine monophosphate kinase</fullName>
            <shortName evidence="12">UMP/CMP kinase</shortName>
            <shortName evidence="12">UMP/CMPK</shortName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914YUQ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g34.t1">
        <property type="protein sequence ID" value="PSU_v2.g34.t1"/>
        <property type="gene ID" value="PSU_v2.g34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006225">
        <property type="term" value="P:UDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="12">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>CMP</name>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g34.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22596" checksum="B7448D77E7B6A467" modified="2023-02-22" version="1">MSFGDKVHNVVFVLGPPGSGKGTQCSKIQSNLGFIHLSAGDLLRAERQRKGSEFGELIETHIRNGSIVPVEITCKLLENAMLASGDSVKGFLIDGFPRNQDNLDGWQREMSDKVKVHFVLYLSAAIEVCVQRCLNRGQGRTDDNEESIQKRIVTYNEQTFPIIKHYEKLDMVREINGEKSSDEVYAEVERAFKNAGFRHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUR1</accession>
    <name>A0A914YUR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3409.t1">
        <property type="protein sequence ID" value="PSU_v2.g3409.t1"/>
        <property type="gene ID" value="PSU_v2.g3409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3409.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35237" checksum="C9668B78DE0C0154" modified="2023-02-22" version="1">MCTAISVVDAKSKIINGKIGWSGGPSIKQLFLLHPSIMYYIAKNPSTPEVYNKLIQSCKYFFEKMAIFVASDLYTTGMYEKTKICLYIDCRHHTKCCINVSLNKLSTKIWVTNILGLDKENILTFSSLIFPKLFRWNNIQLDGFSDNIMYDDFKKVASFLTDFSFWRSQIINNDGSVVMLDKILEITPNIKEFYFSFWDDISMINPATMKNICKLKNLQNVESFRLFHIPEVFNVDDLSTFVKNHQNTKIVFDFVGEISEEYKIQLDALIDTVIESEVHNCRIQYRGQNEEKYKIMNELYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUX3</accession>
    <name>A0A914YUX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3774.t1">
        <property type="protein sequence ID" value="PSU_v2.g3774.t1"/>
        <property type="gene ID" value="PSU_v2.g3774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3774.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17770" checksum="869D3E66D9381E4C" modified="2023-02-22" version="1">MEEFTFDIRPTTGTNPALFVNGNKHFLRAKNKKGSTHWVCYLNKGSKRCQGKARTEITNGKIELANVWDHTCQCTNSTDKTIMSHIDSTKTASPITKHDKHESTKAIQKKKKTIKTVHPADPNYQTLKDLNGDDIFTRKQPTKESDDSGVNLKPGNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVA2</accession>
    <name>A0A914YVA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3593.t1">
        <property type="protein sequence ID" value="PSU_v2.g3593.t1"/>
        <property type="gene ID" value="PSU_v2.g3593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3593.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15379" checksum="E52708DF72ABEBC3" modified="2023-02-22" version="1">MNASNNWIYYTPFGLRNLLNHLDKEYKVPILITENGCMDNFGEDLNDVTRVHYLRGHLMAIAQAVNDGANIMGHTIWSLMDNFEWLDGYTTKFGVHQVDFNDPDRKRTPKLSAGFYAEVATSKILKGFAINQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWG1</accession>
    <name>A0A914YWG1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YWG1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4446.t1">
        <property type="protein sequence ID" value="PSU_v2.g4446.t1"/>
        <property type="gene ID" value="PSU_v2.g4446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000007">
        <property type="entry name" value="Peroxidase mlt-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF51">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4446.t1"/>
        </source>
    </evidence>
    <sequence length="735" mass="82441" checksum="726754C4083237D2" modified="2023-02-22" version="1">MTDIMQHVRCAGENDVEVESSGEEQESKAPGTSPNKGELESKAPGTSGDPVTDDENSSEESDGGGTAGECRDKHDLCKFWQSIGECETNKDWMLDHCALSCDKCNGTTICIDRHRLCTFWSSINECETNAVWMLSNCAKSCKSCKGHAINGQTLPSNGEFRKKDCTFVTTQEDILPRRTISITDVRNSNANFGCVAPLTPHNCKKNLCYHLRFRTFDGTCNNLQQPLSGAAFSPLIRLKEPVYDDVFSAPTSSLNNLRPSAREASRLLLSSSAEITAKSNALLMQWGQFLAHDMAKTTMLNNQQCASCTSANGKCFSVFLSRLDPTFGRFQCLPVARSTPVCGTGQGRFREQYNENTAFIDGSMIYGSSSRDQFLFRQGGFLKTNILRGRVFPPIDSSQNIVAGDDRANIFVGLAALHTVFVREHNRIAIIIQRLNEHWDQDRIFQETRKIVGAVLQKITYDEYLPRLLGRDFKDLIGKYQGYNDQIDPSIANEFTGCAFRFGHGMIQEFYPFLNSSYDQVGGIPFNDGMFKSVHIINNGIDPLIRGLMTLPAKMPQRLTNAVTEKIFGNSDLGSINIQRGRDHGIPGYIAWRKMCKLPEVTTFDDLNSTISNAIVRNNLKLLYKHVENIDMYVGSLLEDPIEGALVGPTLACIIGRQFRHLRDGDRFYFENPDIFSEEQIKELHKASLRKILCDVGEDMKEIPRNAFDQTKDPSDLVECKRLQSPDWKVWKDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWG8</accession>
    <name>A0A914YWG8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWG8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2425.t1">
        <property type="protein sequence ID" value="PSU_v2.g2425.t1"/>
        <property type="gene ID" value="PSU_v2.g2425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2425.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33242" checksum="2817965E2143DAAE" modified="2023-02-22" version="1">MLDKETKRQIYTNILKQSPPGEFNAVFDDLRTMNNDMALLDEQCETTLVEYNHENFLPVTHAELQNSLVTKFNLISNDHYIEPKSNKIFVYDHIQRSVKDVLPNTHAVDSELEEWRAALQKHLDFYVYEHYQKNGVGCVFIYEGNAVICIGSHKYQRRNCYNGRWCSQWVISPFSTKRTTHAVNGRINVLTHYYEDGNVQMSSSKNFTLNVAYPTDMDSAAKEIMKQITEGESSYLVNMQEKFSTFSDQTFKALRRPLPVTRTKMDWSKVHSYRIGKDMTNSPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXW3</accession>
    <name>A0A914YXW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXW3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4480.t1">
        <property type="protein sequence ID" value="PSU_v2.g4480.t1"/>
        <property type="gene ID" value="PSU_v2.g4480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070129">
        <property type="term" value="P:regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033490">
        <property type="entry name" value="LRP130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46669">
        <property type="entry name" value="LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46669:SF1">
        <property type="entry name" value="LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4480.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25046" checksum="5877B57D608866A0" modified="2023-02-22" version="1">MVEIDLKLEPNVEFYNSLLWRLAELKDAQQMENMLLKMASQGIIPNLDTELAQIFAASATGSDKNAEILLDKALQRHGRKSLPDCLSAQIRGTLLHGNVDKFRKLLRSAVTEAESVKYSEEKFAKRFFLNIPYDALFDIIWRLAKLSIGGDGQEFAALSEQILESAQRTTGFFKRLTREAERHIAHKYYYSAAALIGETTRVQRLLDSQRKDGMLHQGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY80</accession>
    <name>A0A914YY80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YY80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5057.t1">
        <property type="protein sequence ID" value="PSU_v2.g5057.t1"/>
        <property type="gene ID" value="PSU_v2.g5057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UAS" evidence="2">
        <location>
            <begin position="112"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5057.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31538" checksum="552C13A8B41A5DC4" modified="2023-02-22" version="1">MGSRDDRSYDSSDADDEVSDLSSIDDEYSDNEDIQVAPSSSSNQNNAESDVRQPLARVTGTLIPENFHNTWRSQVTPSKNDGFQPITDYREVIRQQERELDAARAPKKKEDPIERLFKPPRELMFLGTWERARDSAQANKTWLLVNLQKNSEFACACLNRDIWRNDIVKEIVKGNFLLWQAGDDSSDCQRISAYYNIQTFPTIMVVDPRTGERVQFIRRFKNSDTFIEDLTDFLGLFPDFETYDESVFLKYNTGKSKVAEECERIAQQEADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYG3</accession>
    <name>A0A914YYG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vacuolar ATPase subunit S1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5137.t1">
        <property type="protein sequence ID" value="PSU_v2.g5137.t1"/>
        <property type="gene ID" value="PSU_v2.g5137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF7">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037587063" evidence="8">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="9">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5137.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38810" checksum="6AD4A95DD5CFBF0B" modified="2023-02-22" version="1">MYIFYSLLIFALLGTFSVAVEHSNDLEVERVKRVVVEDVDVDFASNDEPSPARLRQKSPSRASANPSTKDAQPVPNPDGVVPIVLPPYHDANIAPFDTKKRSCLLYLEGITILVLDFKSIGGAQKAYTLPLIAANDSYGYQDSYVVCPPGPKDGGNFTTGTPFSFVIDYRINKPRQLVLENSVVMTVSKGFMLTLNFVSNSGFDLASAVLEGLTIEKGQSGFITKDLIRSTNASNALGTNIRAYFGYNYACSVTPALLFPVKEDPDFLVGIILNNFQVQGYGVDKDGDKTIPYFSTRTADCIPTFNQGTWMGIIVTLILVSVLAFAFLMLNSVQTMDRFDDPKQKQIVINFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYH9</accession>
    <name>A0A914YYH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYH9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g556.t1">
        <property type="protein sequence ID" value="PSU_v2.g556.t1"/>
        <property type="gene ID" value="PSU_v2.g556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g556.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11967" checksum="08B870F9BF532A8F" modified="2023-02-22" version="1">MLAQGMTPTQIHQKYPYYNYFPNTNTGAGYLYYNGYSHGDGKGESINPKIKHGKKVFKWESLEWINKLYSLEVGNIFLWLIKVNFNIFIVPFTRILKFHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZB1</accession>
    <name>A0A914YZB1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">dTCF</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Binds to the beta-catenin homolog arm or to gro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZB1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5833.t1">
        <property type="protein sequence ID" value="PSU_v2.g5833.t1"/>
        <property type="gene ID" value="PSU_v2.g5833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007500">
        <property type="term" value="P:mesodermal cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072091">
        <property type="term" value="P:regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000001">
        <property type="entry name" value="transcription factor 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF38">
        <property type="entry name" value="PROTEIN PANGOLIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="374"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5833.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45857" checksum="52C49FF9F530AAC0" modified="2023-02-22" version="1">MADEGLDEVKVFRKIDTDAVDDEGEDDQLFADKQDVAAEAEIEEETAIQGNSSFQPLGASSAFSAVSPAVPWMGAYLSPAYQMMQNMSLMSPSFYSMMINNPRQLLNQMRPPDSFNQFPSSSTATDPSTGGPIRTPKSSKENRRIIKEEKQKPLIKKPLNAYMIFMKDNRHKVLEEDGNASKQSAEINAILGKRWQQLSEEEQKIYFDKASKEKEEHARKYPGWSARDNYAIHKKKKIIRKIERNNENSESKKCRARYGIDHQDMWCRHCKRKKRCLLVDSEGNASDDSTDSPPTPGSGGDLPDVKPHISTTSASPSLSSTMSAAAQQMQNFMSANMAFPMANPFSFGINGMPTFPFQSLMAFNPAAAAAGMNPQLHQQQPIIHPSSIQRQDDTVLRTSNSNESTTVKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZZ2</accession>
    <name>A0A914YZZ2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZZ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6067.t1">
        <property type="protein sequence ID" value="PSU_v2.g6067.t1"/>
        <property type="gene ID" value="PSU_v2.g6067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="68"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="264"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6067.t1"/>
        </source>
    </evidence>
    <sequence length="695" mass="78191" checksum="735FA738D9E12534" modified="2023-02-22" version="1">MTDSRIVFKKPSDDIDTVTTTVLEEREDGGNIDGGITSSIAVFNPYYTMSIQKQRSMLPISKYKMQVLYAMERFRTVIIVGETGSGKSTQVPQFLMESGWCSDRRLIGITQPRRVAAVTLATRVADEQLCRLGTKVGFVVRFGGVTSDETMIQYMTDGILLREMSSDPLLLRYSVVMVDEAHERSVNTDLLLALLRRLQKVRQDLRVIVSSATLDAAYFRQFFELNDGDDATKDTAVIVSVEGSTYPVDIFYAEKPVPSYAKAALTTTIDIHTKHPSGDILIFLTGQDEVEAFCIDLKEQTRKLKNCDKLWIVPLYGGLSQKEQLRAFDSTPFGTRKVVVATNIAETSVTIPGISYVIDCGFVKMRIADPNNGIETLMIVPISQAAADQRAGRAGRVRPGKCYRLYPETEFKKLLFATVPEIQRCHLAPVILQLKTLGVSNVVRFHYLARPRVKSMANGFDLLHALGAVDDEGALTNNLGTKMCTLPLPPMHAKVLLSSEKFGCSEEILTILAMMQIQEVFNLPRNAKHEAELTKREFSVAEGDHLTMLNVYTAFCANGKTSKWCNQFHVNYKGLLRAQNIRDQLIAYLKKYKIKLISCKGLIGETEKIRRCLLSGFFTNVARYGHDGCYHTIYETSKFNVYKGSSIMYRSEMPKWVLFTDVLQNSIRDLSEIDPEWIQELAPNFYEYGSVRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z192</accession>
    <name>A0A914Z192_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z192"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6131.t1">
        <property type="protein sequence ID" value="PSU_v2.g6131.t1"/>
        <property type="gene ID" value="PSU_v2.g6131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6131.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17775" checksum="167401E9BC7BF482" modified="2023-02-22" version="1">MYTADAKWSPKKDVKYNDLTGRRVRRITFYKPTCRVELSNGQAITANYTELVVVLQDLQPDDHVLIISGMARFQMDRNFLEGKFNDFARFWKDHKSISISGNWCSNPLTSFISTLPKESRLLKMQNFTIHVAGRLHWLLPQGGSHLQYLEQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z208</accession>
    <name>A0A914Z208_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z208"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6738.t1">
        <property type="protein sequence ID" value="PSU_v2.g6738.t1"/>
        <property type="gene ID" value="PSU_v2.g6738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6738.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52489" checksum="C05DF55F8F5AC545" modified="2023-02-22" version="1">MAGSNFLANVERLQADASLRTNPVRRCNTSRGRGVHEHVADRPFGKDVSTAKERATPQGRTRGRPRGRPRSRASLGAASNTTRGTLKRRVAFSEAANADDDEEELSTASESQSKLSKKTKLNKSAAKPRAKKSLRFNPTATNMDDSDDVHSENEHLFDDFDSENLEVADRFFVGKSAACVFAANDLDITAGTVSVNASVVLPVYGMSRVIYDKIEDEDVAIEKAKEYAEGTGKKYGRSDGKYIVFISKPAAPCNHDEQICALEDENVALRVRMEKQEEETAHLKIMVQQQQRMLDRILAGQNPGVHLQGPEGDAASLSASNQTASTGDRNPVSSSTSSNTNITLTLQSLTDAPKWEFIDEQSVAVLYRQHSDPKAFIRALYKSVFTDYDTFLQVLPPAKSVDVIKICMLFLSAVNETTQKNVFGQFHTEWRYQKKLLRNKIIAPQSATAVAMIDKAIPLRKEGALYVPDEDHGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2B7</accession>
    <name>A0A914Z2B7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2B7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6217.t1">
        <property type="protein sequence ID" value="PSU_v2.g6217.t1"/>
        <property type="gene ID" value="PSU_v2.g6217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6217.t1"/>
        </source>
    </evidence>
    <sequence length="390" mass="41901" checksum="7FFE8595760A6655" modified="2023-02-22" version="1">MNKPCDHISGKCLGCPKGFTGYSCTELCPPGFYDDCITKCQCEENSDCDAISGKCFCKPGFKGHDCKEGCPSNTFGIGCKEICQCRNGGICDSVTGKCDCPSGFVGGLCEVACPKNRYGKNCEKKCECQNDGICDQFGTCKCPAGFTGIHCEQVCPAGRWGAGCKEKCRCANQGRCVATTGECKCSLGYTGQFCDQSCPRGKYGINCTLDCECHGGASCDPVQGCCDCPVGRYGTRCQFTCPLGFYGWYCSQRCDCLNGATCDPSDGKCLCPLGFEGDKCQRTCANNTYGPHCSLTCDCGDYGCDPVDGSCDCPLGLHGPKCKQVCRPGRFGKDCKERCECYNGAECNKVNGSCQCSPDFFGATCQQEYADPESIASRGDLPEYLYRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2D7</accession>
    <name>A0A914Z2D7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2D7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6064.t1">
        <property type="protein sequence ID" value="PSU_v2.g6064.t1"/>
        <property type="gene ID" value="PSU_v2.g6064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="entry name" value="TonB-dependent receptor, beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="Beta-barrel_TonB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6064.t1"/>
        </source>
    </evidence>
    <sequence length="481" mass="54377" checksum="2DB5518279903BDE" modified="2023-02-22" version="1">MDSTQSTSLNQGDIRPEKISIHGASPYQNAYLIDGISATNNLNPANESDASSATNISGMSQGYYLDVSLLDNVTLYDSFVPVEFGRFNGGVIDAKIKRFNADDSKVKLGYRTTRSDWLTSHIDENNKSAFNQGSSGSTYYSPDFKKNFYTLSFNQELADNFGVTAGLSRRQSDITRADYVSNDGIVAGRAQYKNVIDTALSKFTWFASDRFTHDLTLKYTGSSRDYNTSTFPQSDREMGNKSYGLAWDMDTQLAWAKLRTTVGWDHISDYTRHDHDIWYTELSCTYGDITGRCTRGGLGHISQAVDNYTFKTRLDWQKFAVGNVSHQPYFGAEYIYSDAWTERHNQSESYVINAAGKKTNHTIYLKGKGRLGIDNYTLYMADRISWRNVSLMPGVRYDYDNYLSNHNISPRFMTEWDIFANQTSMITVGYNRYYGGNILDMGLRDIRNSWTESVSDLLKHGFHASTERVSVGEYAGLARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2Z3</accession>
    <name>A0A914Z2Z3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2Z3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g643.t1">
        <property type="protein sequence ID" value="PSU_v2.g643.t1"/>
        <property type="gene ID" value="PSU_v2.g643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037042284" evidence="2">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g643.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26796" checksum="BDE58DB2AD4B6EF5" modified="2023-02-22" version="1">MFAANILLLFITVKSVTVDSFSIKELSADAYSSQVAVQIGKDVRLKTGTNIRDVDLILTNGFLEVEMDFKNCMGKSHFCYNSTDKMDQLNDICFPGYCAFFVEGVRGYDEYWKESFDRIKSIDDYTLVNRQKSYFSCKSNIVRMQYWKTLYCEKPFYSCASLIDKENKTRIYVNEISPSCSIKIKNAQIYNRSMANSSMLSSTPPPTAEASTDPWYLWLILGIIIVGIICTLIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3H7</accession>
    <name>A0A914Z3H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3H7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4806.t1">
        <property type="protein sequence ID" value="PSU_v2.g4806.t1"/>
        <property type="gene ID" value="PSU_v2.g4806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002461">
        <property type="entry name" value="Zinc finger matrin-type protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4806.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24698" checksum="7912F25D69B1BFA9" modified="2023-02-22" version="1">MSFYQQTGAAASGTDHRRKWDSNEYQAKANERLAEEKAAMEAKKNKEKPKGPKPRRELLHARDEKVDLESKVGKQVTVNKATATEESGGFYCELCECSLKDSINYLDHINGKNHQHKLGYSMKVKRSTVDDVVNRFAAKKAELLQKSKKKDAKDEEETLKEEQAKMADSRRQKHEIHRKRPHKEEEEEVAEEDEPEDEMAQMMGFGGFSTSKKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z517</accession>
    <name>A0A914Z517_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z517"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7063.t1">
        <property type="protein sequence ID" value="PSU_v2.g7063.t1"/>
        <property type="gene ID" value="PSU_v2.g7063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF57">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="168"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7063.t1"/>
        </source>
    </evidence>
    <sequence length="668" mass="76508" checksum="6CBDFA5A3610B2F5" modified="2023-02-22" version="1">MDPHEVLSSLDRLQKLIGKEIEFGDLSNNTFVKHRYYEKNFLKFPDTFPENLLKLNEQKYFPLVYAVEAIVSRGGSSYDYFFRKPYACFEPFLKLVSERYENDLEHEPNKKLTRTVRALELMLVKFDHILNIPEPIAFFTKCYEQLSEFESSSELIKTGFMRIRKVIVTPSRVLLCNPDIVPGNRCLRKYGDDNMIRVIFRDENLSKLYGVQKILIVKTVENFLKVPQWIGMRQFSYFCSSNSLLKDHGCYFVAGTQEDVKEFRIQCGNFKVESIPKMISQLGQCLTQSHKSSFELNSNDYCEVPDNVGGLDANGNPFIFSDGVGKVAKQIALDLGHPDYLPSCVEFRFRGYKGILSIDSSFDKTRTALLQNQRNNNNNTDESYHKKIMFRPSQKTFDAPKDNSFEIVKVSMPICVNLNKPLINILDQVTEKQDSVIHTKVKNRITSLLDRDILGIISTLIDPKSACLALKEFSKLIPYQLFDNFNITEEPFFRSLLFSSARIRLNRLIEKINIRIPSTHGRMMIGVFDESGILEPGQVFIRYTTDANLKFPSESSDKTTLVGSVMITKNSSIVPGDVRMFEAVDIELLHELIDVVVFSGKGDRPNSNEMSGANLDGDQFKVIWDSEFILHHNEKSFDYHSPSATEIPESFNDPNSDNTVSDLMIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z520</accession>
    <name>A0A914Z520_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z520"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7780.t1">
        <property type="protein sequence ID" value="PSU_v2.g7780.t1"/>
        <property type="gene ID" value="PSU_v2.g7780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
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        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7780.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13787" checksum="56259002A1AF7C23" modified="2023-02-22" version="1">MPPKPSGKGAKKAVKSQKVARTGDHKKRRKARKETYSIYIYRVLKQVHPDTGVSSKAMSIMNSFVNDVFERIAAEASRLAHYNKRSTISSREIQTAVRLILPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z581</accession>
    <name>A0A914Z581_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z581"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7119.t1">
        <property type="protein sequence ID" value="PSU_v2.g7119.t1"/>
        <property type="gene ID" value="PSU_v2.g7119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7119.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12538" checksum="0376B98EFBD1DED0" modified="2023-02-22" version="1">MEGETDSDPMATVHKLLYEFEAKNLNTLKQKAEMEQEITVLRKTLSSRGEEERRKAKDLECMRETMKNLSEKNKFLAKELERKIDAEAECVAIKSAASKVQKENELISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z629</accession>
    <name>A0A914Z629_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PIPK domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z629"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8135.t1">
        <property type="protein sequence ID" value="PSU_v2.g8135.t1"/>
        <property type="gene ID" value="PSU_v2.g8135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
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        <property type="entry name" value="LP03320P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIPKc"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8135.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15042" checksum="536FCC8E08B2926C" modified="2023-02-22" version="1">MQHKFDLKGSTLKRFASKAERAKSNPTLKDLDFNEEYKNGIILDSSTYDIIMDIIKRDCMVLESFKIMDYSLLMGVRNIDFEVEVNGDPNLLNDEGGEGSIGGSSSVAAERAQARNEAWKSYQLDFNTRTPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6S9</accession>
    <name>A0A914Z6S9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Asparagine synthetase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6S9"/>
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        <property type="protein sequence ID" value="PSU_v2.g8038.t1"/>
        <property type="gene ID" value="PSU_v2.g8038"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000263">
        <property type="entry name" value="Asparagine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF23">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="84"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8038.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32603" checksum="067679256DF31BC7" modified="2023-02-22" version="1">MCFFDLAEFLDIPHKILVITPQDCLDIIPEVVYALETFDPLIIRCGIAHYLLCRHIAATSDVKVLLSGEGADELFGSYAYMQRAPNASHLHRESLRRMKHLHQYDVLRCDRSTSCHGLEIRVPFLDKKFIEFVAKLPPNFKLIPNQMEKYVLRSAFEGWLPTEVLWRSKEGFAEALGKIDLGDVVSEHCEKIISDEKYELRGETFPWKCPETKEEYWYRALFEEFYSIEKMDTIIHTKVYRTAAWHLTDEKENCKDDLLNIEAVRFRRRSTGSAKFSGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7M5</accession>
    <name>A0A914Z7M5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7M5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8694.t1">
        <property type="protein sequence ID" value="PSU_v2.g8694.t1"/>
        <property type="gene ID" value="PSU_v2.g8694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8694.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39100" checksum="EF538DC2FA16285D" modified="2023-02-22" version="1">MIADVTAVTESVAEEKEGSTSVSSTTITSSSIHSSVHSKSAVKSPKSYNLTNESTSTSPKYDTSAWCHNSQNQYESDNFMDDEHTSESKNSENVEAKLNESLLDQDVNVLLKHPSSSDFKSSKSHLTSEVDVSFKDLEPLSDTSYTAAFKTSPTQISDDRCSRLSTVSTSSYFAKNPDVNMFYSPQIPIEHKPEKVVEKIKKQFEPFKTAAEEEAEYLPETNALKSKYDEVIPKSSPLKVPRSPINIFESVGEESQEEIDDYIYGEFDEMVTEEEGEYLPRLLSPISEHYSAESGTGSSSFCSISQLSVHTAIEREYADVEEEDSRGESGSPTSFREYWRDAGELAERCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8Y7</accession>
    <name>A0A914Z8Y7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8Y7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8377.t1">
        <property type="protein sequence ID" value="PSU_v2.g8377.t1"/>
        <property type="gene ID" value="PSU_v2.g8377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8377.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14133" checksum="22F42EDA8D1432AB" modified="2023-02-22" version="1">MTKVKPVYKSQFSVPAYCVLSSDDDNSPTDTSPNNFTGNEHFAVFYTPRFNEIPREQQHSHPLSPQIIGRSPSIKNKNASPFKFPKHLSFKAIKNTLTDLDIQSYSDPILRSNNRKVEGLFLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9C4</accession>
    <name>A0A914Z9C4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP synthase F1 complex delta/epsilon subunit N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9C4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g852.t1">
        <property type="protein sequence ID" value="PSU_v2.g852.t1"/>
        <property type="gene ID" value="PSU_v2.g852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g852.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10019" checksum="FB125545D17FAF93" modified="2023-02-22" version="1">MTTIIPGKVTVKTADGKSDAYIVFGGFADITPEGCSLLAESALHIDEIKREDIAARIEHARKLVDDASSAEHRTKAEMFLHQLTTLEGAILPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA55</accession>
    <name>A0A914ZA55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA55"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8665.t1">
        <property type="protein sequence ID" value="PSU_v2.g8665.t1"/>
        <property type="gene ID" value="PSU_v2.g8665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00276">
        <property type="entry name" value="C2B_Synaptotagmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF344">
        <property type="entry name" value="SYNAPTOTAGMIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8665.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16441" checksum="80E5566DDFB19476" modified="2023-02-22" version="1">MDYDRFSSDDPIGEILLPMKNVKFNKNPVYWKHLQRPTVSKETVGEMMISLCYFPENNKMNVSILRAKNLPNRDKLGSADPYVKIWLVQKGNKIEKRKTGVKPQTLAPVFNEAFSFALPAKEKLESEVNFVFSVSFFFSPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA75</accession>
    <name>A0A914ZA75_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="2">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZA75"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7144.t1">
        <property type="protein sequence ID" value="PSU_v2.g7144.t1"/>
        <property type="gene ID" value="PSU_v2.g7144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000037">
        <property type="entry name" value="ATP-binding cassette subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF330">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7144.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26339" checksum="5CE1AABCD80BD74F" modified="2023-02-22" version="1">MDYGYYFATLMLVTSFLSALCDFNFNFYVNKVSLRVRCATVLSLYDKLLQVPICRLAKFSSGQLINFMSTDVDRIVNFFNSFHALWSLIFKLSVALYLLYREVGLAFLSGFFAALLMVPLNLYITFKIGSMSGKMMAFKDQRMRLITETMRAIRTVKLSNWERYFENRIEHIRSKELKYLSRRKYLDAVCVYLWASAPVLITIAILSTYTVIMHEKLTAAKVCCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBE6</accession>
    <name>A0A914ZBE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9242.t1">
        <property type="protein sequence ID" value="PSU_v2.g9242.t1"/>
        <property type="gene ID" value="PSU_v2.g9242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF159">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="175"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9242.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36310" checksum="F12C63C48A5A0BD8" modified="2023-02-22" version="1">MRINYFDLILGKEPGIPYLAGEEIIGKIEIHVQEKTRIARLTVRLLGQSHTAWRNKASDILYESKELIMDDYVDLTNDLALHCTEALEISEGKHRMEFKMKIPYDVVSSIEKDNYGSIQYTCSAILDIPEDGESEIVSEREVLIYSLLNLDAPHFRQSVRAHDQVNVIGCLCRRPKGWISAELIVGELGLMPGEIVKISLIIENTTKRRKSKKHSKAHECALLSLCQQLDFRAQNRYNPQMYDEKFLTIAVESEGTCKANDNKGPETKLIAFKIPENLPPTSTKANGLITCSYFFKLDMEHFDLVVPVVIGSAKTAEPILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBL7</accession>
    <name>A0A914ZBL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBL7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9708.t1">
        <property type="protein sequence ID" value="PSU_v2.g9708.t1"/>
        <property type="gene ID" value="PSU_v2.g9708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037273202" evidence="3">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="102"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9708.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20344" checksum="913CB09B7BB5112F" modified="2023-02-22" version="1">MHLSIFTVIFGITVFVEIYAHTELNDDYAIVHTYPAGYVNGISKRNCTSDNAIIDKLLNGTGYSKFRVPSDTGVDVSVEFWMETVNTIDELSNDFEMDLYINERVRVKGPCFMDLSNFPMDVQTCNLIYESFIYNSQEVRMRWNPAAENPVAVTGRILLPDYNLIGIKNFIKAMPYPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBY9</accession>
    <name>A0A914ZBY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MnmG N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g984.t1">
        <property type="protein sequence ID" value="PSU_v2.g984.t1"/>
        <property type="gene ID" value="PSU_v2.g984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003739">
        <property type="entry name" value="PRK05335.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MnmG N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="MnmG N-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g984.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="21839" checksum="670AE89D001D95FF" modified="2023-02-22" version="1">MRPVRGTDAHKTQGLAELVCSNSFRSDDAETNAVGVLHAEMRLANSLIMACADANQVPAGGALAVDRDGFSDAVTAKLEAHPLITIQREVIEAAELAEAIAKETEADSLAFFDAIAPIIHFDSINMDVCWFQSRYDKVGPGGTGKDYINCPMDKEQYEAFIQALIDGEKTEFKEWEGTPYFDGCLPIEVMAERLCGCAVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC47</accession>
    <name>A0A914ZC47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC47"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9492.t1">
        <property type="protein sequence ID" value="PSU_v2.g9492.t1"/>
        <property type="gene ID" value="PSU_v2.g9492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9492.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29258" checksum="354E1021150E4D31" modified="2023-02-22" version="1">MLLEIGEGRFGDNPNEIEIPPECVSKGDIIDEIFGDVMENYDPATVMKRAILATWNKDVDELNEQVLELFDEQTEKIYHAQDIYHYGDEILQNAGEIHENYKVRNIKGLPSFKLRLRKNAIVMLVRNLSIEEGLCNGTRLIVTNLLKHNLVVKKINIDGTLSDEILIPRITLTTKHGVVEVTRHQFPVKLAFCMTINKSQGQSMERVGVVLNHECFSHGQLYVAFSRARSMEGLKVVLPGGKTTTANIVYKELIALGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC79</accession>
    <name>A0A914ZC79_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZC79"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9336.t1">
        <property type="protein sequence ID" value="PSU_v2.g9336.t1"/>
        <property type="gene ID" value="PSU_v2.g9336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="82"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9336.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="26122" checksum="45657650B0BD67B7" modified="2023-02-22" version="1">MPEYKLSYLPIRYLAEPARLIFHYAQEEFEDERLSFDEWEPIKQSSPFNTLPLLTINGHQQIGQSMTIFRYLAKQFGLDGGTDFEDAHINCVAEYFREMMEKARPFVRFWNRGIVEETVEKKDQDPEFPLVVQQLKLHLEPHIREYFPVIIKLLKESKSDYFADSGVTWVDFFISEYVDSLQNVAPELAEQYPELLEHSKIVHSIPQLQSYLESRKYTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCU9</accession>
    <name>A0A914ZCU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiolase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCU9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9515.t1">
        <property type="protein sequence ID" value="PSU_v2.g9515.t1"/>
        <property type="gene ID" value="PSU_v2.g9515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9515.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30901" checksum="C51F447BAABE295E" modified="2023-02-22" version="1">MTGIPIYNVNNACASGSSGVYLCKQIIESGNADCVLACGFEKMLPGSLEAMSSNPDGRAIAVDKHLEVMSDTYGLFPAPMTCQMFTNAGKEHMEKYGTKREHFAKIAHKNHKHSVHNEKSQFRKEFSFDEVMNARKIYDFCGLLECSPTSDGSAAAVLCSEKFLQKHPELKKQAVEIIGIELRTDFPSAFSEKSNIKMIGFDMVERAAKDLFRNANMTPNDVQVIECHDCFAANELYEFIGGPYSDLIGYNTSSHYDRFHKRCRPWNFANMAGMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDM0</accession>
    <name>A0A914ZDM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDM0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9779.t1">
        <property type="protein sequence ID" value="PSU_v2.g9779.t1"/>
        <property type="gene ID" value="PSU_v2.g9779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9779.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18572" checksum="C7B1D481319F47A8" modified="2023-02-22" version="1">MILLFEVLYQTGNWFRGPKCEKQNLSKNYLSSFIPAISFLSNVEEIRLISVDDTRHYLYTLGDKGTIEVYDLGADGLKLERKKSSSLLDIRREIRSTCGVEDEFLAGIIAINAIPSTRSQYVCLEAVTTKGMRIYFTVYPNLVPNYPIEQQDARASTLLKFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGN2</accession>
    <name>A0A914ZGN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGN2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9445.t1">
        <property type="protein sequence ID" value="PSU_v2.g9445.t1"/>
        <property type="gene ID" value="PSU_v2.g9445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036834229" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9445.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9687" checksum="9A7623EC0EF35D18" modified="2023-02-22" version="1">MMRQLIILTFCLLLIISSAVDIPSKIEQDFNSIAADTHNHEHEEGIMGKAARVVREAAEGVVDTLSPEDMAAREALIKNTPVRTKSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQ09</accession>
    <name>A0A914XQ09_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914XQ09"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10103.t1">
        <property type="protein sequence ID" value="PSU_v2.g10103.t1"/>
        <property type="gene ID" value="PSU_v2.g10103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10103.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32468" checksum="0CFF1AC6E0CB3293" modified="2023-02-22" version="1">MSESDSDAKVETNKAENASKEPAEDDGLPKMPQKRYYRQRAHVNPHSFHNLEYPPTPDELDLTKYYGEFGKGKNIEFADIGCGYGGLLMRLSPMFPDTLMLGMEIRLKVSSYVRDKIIALRARNPDEYNNIWCQRSNAMKYLRNFFRPHQLNKMFFLYPDPHFKKAKHKWRIISPALLEEYAYVLKVGGLIYTMTDVKDLHEWMVKHLSEHRLFERVSEEDMAKDPVVPLLGNSSEEGKKVERNNGDMFPAVFRRIEGESKPTDCPVPPKMLKRAPKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQP3</accession>
    <name>A0A914XQP3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XQP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10329.t1">
        <property type="protein sequence ID" value="PSU_v2.g10329.t1"/>
        <property type="gene ID" value="PSU_v2.g10329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10329.t1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51462" checksum="AB4470F79810E4BC" modified="2023-02-22" version="1">MPKNLSFAPDFTLEAAQGNIWDDDSFAKLRKMMAFMNGIRSGFCELVLNDNENLDKLREENFDLAITELFEACGLGVFKKIGIKKHITTFGSSLFPSSSSLLGIKLHPSYLPGMMAKSTDIMNFKDRVLNFVYYIVENWMVKSMFTSGVEKAIKKQFPDFSMDEAIADSAFFFVNTDEHVDYPQAITHKVIYMAGLGKVQAHPLDKQYTEIFDSAKKGVILFSFGSVVQSSFMKPELKQAFLDAFAEFPDINFLWKYEKDEHQIAKGYKNVFTGKWLPQNDILDHPKLLAFISHGGMNSVMEGSSKGVPMICIPIFADQKRNSFLLQRRGTAIKIDKSEISKENIVAAIKEIINNENYRKNAKMLSKMVNSKPFSPADRVVKYAEFAAQFGDTGTLQTQGRYQSLIVLYSLDVIFFLLTVFSISIFLLIWGVKKFLNFLRRKLSRNNEKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSD6</accession>
    <name>A0A914XSD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10897.t1">
        <property type="protein sequence ID" value="PSU_v2.g10897.t1"/>
        <property type="gene ID" value="PSU_v2.g10897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36943">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36943:SF1">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10897.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12879" checksum="1CF7392F4B6FAA2D" modified="2023-02-22" version="1">MPLCRKILSFDQENVPKIMISPKINGKVFEFILDTGAFATMANKEVWEAIGKPYLHPSNRAVGGIGGHVLPLGRCRVSVEIHGKTSREWLYIIENGMMLFGRNWIDSLTIKIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XST0</accession>
    <name>A0A914XST0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">50S ribosomal protein L7/L12</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XST0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1033.t1">
        <property type="protein sequence ID" value="PSU_v2.g1033.t1"/>
        <property type="gene ID" value="PSU_v2.g1033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1033.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="15664" checksum="815F2B2F85028B3D" modified="2023-02-22" version="1">MGATTLDAEGVKALASLPSLDELRAKLEYTMADLAKIVEDLSALTVLEAAELSKLLEEKWGVSAAAPVAVAAAAGAAAPAAEEKTEFDVILADGGANKINVIKEVRAITGLGLKEAKDLVEGAPKAVKEAASKDEAEKIKAQLEAAGAKVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTR1</accession>
    <name>A0A914XTR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10653.t1">
        <property type="protein sequence ID" value="PSU_v2.g10653.t1"/>
        <property type="gene ID" value="PSU_v2.g10653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="115"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10653.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28348" checksum="5CF30545AD1D030D" modified="2023-02-22" version="1">MFDNIFLSNEAGKIFTNVTNSDFWFGANDLFSQGIWSWMDGAPFHFNDWDNGQPQSSLDNGCGAVLIQGAKWISDNCFKQKPFVCTISALSEIKPTTTLAPSQNLCSEGWTYFNYTGFCYMVLVEEMTWDAAEKACIAEGSHLISIHSWREMIFATDLASPYSSNACDWHAQTWIGFYTKDVWKNYQWSDGTPFDYKSWGPREPNGPEGLNNCGNIWTGVPCIGTDWVPAELYDYWCDNTMETSICKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU28</accession>
    <name>A0A914XU28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11463.t1">
        <property type="protein sequence ID" value="PSU_v2.g11463.t1"/>
        <property type="gene ID" value="PSU_v2.g11463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="228"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11463.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38096" checksum="7BDE77F59A5329E7" modified="2023-02-22" version="1">MVVQTLKFCKRQWCYTDDETVIKFGENLEFTVVFDEDCNLFFIENIKGDLEITKITTYDSDQEKEIKYGNNAFYSEMAAHYTFHITAKIESEEMCAVNYNLFIPSNRLNSLKLHQYFESEFVLPGYNYLKFTYDVRRMNFNGDENDIEIIIKNSCDVKIQGKKMGRDAVLKANPNMDVNLNLLFCFNPNVYQPTVNSESESRPESAIPSYLSNENSKLFKIASNDRFADVFFITSDETKIPSHRNILAECSNIFAQIFEESTEIPVKINVNDFSVDTIQSALNFINGKPDSFVGKEMEVFKFAVKYAIQDLIVRSMLFILSRLGCSNKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVC1</accession>
    <name>A0A914XVC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVC1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11184.t1">
        <property type="protein sequence ID" value="PSU_v2.g11184.t1"/>
        <property type="gene ID" value="PSU_v2.g11184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037228616" evidence="2">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11184.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27013" checksum="B81DCADA6136892D" modified="2023-02-22" version="1">MINRLFLLFIGFQLFNVILTENDDCLDLDGNCRDWIASDSNLCHSTEYITKSCRRSCSFCIHIPDKFDLTKLPSSLKPVAWLIGIWRSEHGGKAVFPTIPKFTYGEQIEFSLTDSHTVSSKSLNYTAFAWGINDRDELHSENGYLTVREGTNEVALTTVMSNGFVTIEEGPVKSNQIRLRVVDIGRISFSRDLPVHDLIREWTLLDSQTLQARLDMSTLTHGMQEHTFIRYKKIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWA7</accession>
    <name>A0A914XWA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWA7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11514.t1">
        <property type="protein sequence ID" value="PSU_v2.g11514.t1"/>
        <property type="gene ID" value="PSU_v2.g11514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="4">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11514.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17737" checksum="322224FC7E5697A1" modified="2023-02-22" version="1">MMGGIPTKVTGQALTVNEKGEDVVVPGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGLHLQESIAEQGALRDASESDVEASLDRLNRWNNNRNDEDPVAMRKALQECMQHKLSVFREGDAMAKGLEQLKVIRERLKMPVWMTLPASSTPSALSVWNWIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX48</accession>
    <name>A0A914XX48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX48"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11107.t1">
        <property type="protein sequence ID" value="PSU_v2.g11107.t1"/>
        <property type="gene ID" value="PSU_v2.g11107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11107.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22966" checksum="A21548390FE68C93" modified="2023-02-22" version="1">MITDSIRYAAEYIAYFFYSDPFVSGEEIEKFTIELANSILKTIYQNEGCRKKLNQHTLINSQRECCQGSDEFVMELNVDGRLASMIGDIAQSVMTLTPQEIADLLPDNTYVVVSECYAFYSINHGPCVFIYKTNGCKFNETAFRLKRNPIIRYNNASQCFEYYFRFWISEYFRDKIFQIFAETFCIMYILDKSKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYZ2</accession>
    <name>A0A914XYZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ISXO2-like transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYZ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12174.t1">
        <property type="protein sequence ID" value="PSU_v2.g12174.t1"/>
        <property type="gene ID" value="PSU_v2.g12174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12174.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9935" checksum="BD3C33089B1C4E3F" modified="2023-02-22" version="1">MTSVQSRDRETLYDVMRRHIRPGSIIISDGWTAYATLVELPEGYIHKAVNHSENFVGTVSGAHTNIVESLWQKFKLRHNVDYSTCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ68</accession>
    <name>A0A914XZ68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10965.t1">
        <property type="protein sequence ID" value="PSU_v2.g10965.t1"/>
        <property type="gene ID" value="PSU_v2.g10965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10965.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35425" checksum="A974040420C16725" modified="2023-02-22" version="1">MERCIYCQKFILPNNRIALPTSRERRIAFAAALELDEATILNLPKLRYLCTSHFLPTDFYRNDENKITGLQRSALPRQNNPQISENPTFPHLQSFNHLSTVTTAVIPPLSFHPNLSLPKTSITSPTLIMPQSKDIENVPTDDFSNDFDVSDDFGENNDNEINAKINYDKQNEKKKEDIRPKKKYKKFVEPIINLDEMDTFLLNKKKDLMEEEIDEDDDERVEYVVISTKRLLSIFTACPICHAILGNTKKMIKIIGTAASITFRCSECLPNPKTWATQDKIQGTKIYTGNALLSSAAIITPVPFTVRFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZV9</accession>
    <name>A0A914XZV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZV9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12740.t1">
        <property type="protein sequence ID" value="PSU_v2.g12740.t1"/>
        <property type="gene ID" value="PSU_v2.g12740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037701290" evidence="1">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12740.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="5810" checksum="238DCD6122DD52CD" modified="2023-02-22" version="1">MVRIAGLLILCFAVGAHTFGFGGLGGGGGGGGCGGGCGGPPPPAPCGGGCGGGAPIGGGCGGGCGGGPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y065</accession>
    <name>A0A914Y065_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y065"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12856.t1">
        <property type="protein sequence ID" value="PSU_v2.g12856.t1"/>
        <property type="gene ID" value="PSU_v2.g12856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12856.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38007" checksum="29117932590974D2" modified="2023-02-22" version="1">MFRARHFVPAIEEDDIEVAKIKLKNVLGLDDIKNDCDETSESDEDKYEADGKEFYVVEKVLAHRVVNEKQEFNVKWLNYEDHTWEPLENFVTKGSKMEIYVYFQKKWEKKVAQNQHETLGVGSSSVAKHNQVGRSFGSSHPVPKKESSKVVQEDATAGPSNVTAKKEKERQAGDSGSSSVSLKKKEQNVSYCNSVAGSSKVIAKKGKHEQKPKNKMLDVSFRPKEPVEKSKQRHVEKRSLPSSSHSMQKIQKFKGTTRPMFSQSLNDLKRKMEVQRQQIKERAEKRKKEMDEQERLAREAAEESARYEKIRQEVLADLGSSSDEDDALVDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0W6</accession>
    <name>A0A914Y0W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0W6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13094.t1">
        <property type="protein sequence ID" value="PSU_v2.g13094.t1"/>
        <property type="gene ID" value="PSU_v2.g13094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13094.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7856" checksum="A6A03E219E8E18DB" modified="2023-02-22" version="1">MKVIVLDESKEISYFGDCKLQSNGVDKCLKLQMLDKDPQEIMISSYDQIYICKKNFLCVFDKKANNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1B3</accession>
    <name>A0A914Y1B3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1B3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1258.t1">
        <property type="protein sequence ID" value="PSU_v2.g1258.t1"/>
        <property type="gene ID" value="PSU_v2.g1258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019425">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23021:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10321">
        <property type="entry name" value="7TM_GPCR_Srt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1258.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13284" checksum="29273D170A21FA60" modified="2023-02-22" version="1">MIIALNRCLEMYDHHLCAKLFDGYKVLLWLMIPTCHALFITFFTTPIVFSGLYVSWFFNPHLGYFEDNGVRYVNWFHVVNNITLVTVLTTLYGVFVIVYIKKAHGASTTQKQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1M3</accession>
    <name>A0A914Y1M3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y1M3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12681.t1">
        <property type="protein sequence ID" value="PSU_v2.g12681.t1"/>
        <property type="gene ID" value="PSU_v2.g12681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="168"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12681.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="46153" checksum="D93869E91854E731" modified="2023-02-22" version="1">MSDAPGTSVPAPHRPFKRKAGSFYNGSKRLRCGPNSYLIVGNKHDPLNLESDEPEPFKEPCPPSPVDETDPLCLKSPPRSAKKKKKKHEKPQFEDGMNPVFVSQRRFSVVQQKIKQSYLQQQTSQSNVMETSSAPKIQEQKTVANNYKYRFGNFNRYYGNMPMDALLDNRLNFLCKDMFVDKDVLDIGCNSGLLTISIAREFLPKRIIGMDIDGHLIRAAQHNIRYFCDRDMKFMHRFPMSFPHCFGPITAPVYPHTLNESTEFPHNIKFICDNYVLENDDILEKVEQEYDIIILLSTTKWIHLNNGDEGLKRAFKRIHRQLRPNGKFILEILTFDGYRRSANTCNILKNNFDKIAFKPDQFADYLLSDEIGFRHYEDVGLAYAGFKGPLLIFFKENEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1V9</accession>
    <name>A0A914Y1V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1V9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11799.t1">
        <property type="protein sequence ID" value="PSU_v2.g11799.t1"/>
        <property type="gene ID" value="PSU_v2.g11799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11799.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11065" checksum="229FAF9CC4195579" modified="2023-02-22" version="1">MPAAINGSHTMTMKTSTKSKITLKNNQQMQCLSIFDGNDCLKTPTVPDMLKTPTITVSPTKHANYLGHVDDLNTPGVSLNPCPTTNNTQAFFGDHEPLFTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1X0</accession>
    <name>A0A914Y1X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1X0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14178.t1">
        <property type="protein sequence ID" value="PSU_v2.g14178.t1"/>
        <property type="gene ID" value="PSU_v2.g14178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF175">
        <property type="entry name" value="TEP (THIOLESTER CONTAINING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="8">
        <location>
            <begin position="78"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="9">
        <location>
            <begin position="701"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14178.t1"/>
        </source>
    </evidence>
    <sequence length="861" mass="95947" checksum="74E118E8D760F7DC" modified="2023-02-22" version="1">MMRMRDSSAVMLDSAQVSGDIGVIKPQIMYAMRSMGAPDLMMPRLSPERTFFSSTPAAGRISPQSQPKVYVRKEFPETWLFSNLFSNSGEVTYEAKAPDTITSWIASAFAINEQSGLGVAPSTAKLKVFRPFFIRLNLPYSVKRGEKFALQVLVFNYLENEQDVTVTLKYYDGVGFSFLQKDGSIKKNKMDKNYNIRLVSVPGGVSKAVYFPIVPNKIGNIKLSVVASGAQAGDAVEIPLKVEPEGYRVDRNVPIVFDLSQPDAAKNETLTSRTVALEFPNDVVEDSRSAKVDIIGDIMGPVLANIENLVQMPFGCGEQNMLNFVPNIVVLKYLKATQRETSTLEAKALRYMEQGYQRELNYRRDDHSFSAFGQSDSHGSTWLSAFVTKSFKQASSFIFIDSAVIQNAIAFLNSKQTQAGAFAEHGEVHHKDMQGGAKDGGYGLTAYVLVALLENGVNNQMAVEYLENNLDNASNDSYSLAVATYALHLAKSDKASEALKMLENLQVQESDGGIHWSSKSADETTPSKQDSSIKYFYQPPPVDVEMTSYALLTYMTMNNTEKGLPIVRWLSGQRNANGGFSSTQDTVMALQALGAYAEKAYSPNLSMEFFVESGNENHNFSITNQNAIVLQSYEITNLDSSIKLHASGHGVAFAQVQYTYYRQNMRDNTPFFCTKELKEQKSGNRMELNLCCNYTVFGERSNMAVAEIQALSGYQFDNEEIDKLTNIEDLQRVELDKDDTRMNIYFNALDENPICLSLYSNAIYQIADQKPAQIRLYDYYNPEQQLKSDYSTRQTRSLADSCPDCWPEANADETSSTNLQSNGGSSSQIRSTNRASRALCELNSFMLFVSVIMFVLTLARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2V3</accession>
    <name>A0A914Y2V3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2V3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13109.t1">
        <property type="protein sequence ID" value="PSU_v2.g13109.t1"/>
        <property type="gene ID" value="PSU_v2.g13109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13109.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="30751" checksum="2F8C3D9AD36B936C" modified="2023-02-22" version="1">MPYDQRRQSIGVANFVAPRENFTPHSTNSSFYTPTPGNGVLSRPHNHPGIASLSISSNSPSMYLFNNGNLPNSPKQSMIGQPPNFVHRKGSAIPQNFGPTQNNQPTRENRKKAVITVDAQTTEILIANDSVCRLFSLKDRSLIGRKLKDVFTGKDVDDLRQLKHTSFYCDDPEEGTKPIIVNNALFSKNGKLTPVYGKPVDIIDADGVLSTVCVWSYPLTPAAAMATQRKNSALLSRSPSERIPASILSDIRNRKDDPNHHSVLFSIKSEFSISSTVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y322</accession>
    <name>A0A914Y322_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y322"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13175.t1">
        <property type="protein sequence ID" value="PSU_v2.g13175.t1"/>
        <property type="gene ID" value="PSU_v2.g13175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13175.t1"/>
        </source>
    </evidence>
    <sequence length="509" mass="58906" checksum="89B13BF3E49BFBB6" modified="2023-02-22" version="1">MSEDTNDPEKTICEVSQWKMPLEKRTQIFQYVVAAIGNGKSKNLCTTGQYVDKKRCKEAIEKIFPKRYYIYNNQEILYLHEQLDIDIKETIPSLNGDLESLNGDLEISITFRAKIDISNINEIRAFLNTALNQFSINENKYSFVGKGQIYEVQDDETDEARKYKKYGLVIRHGNSKGVQFINNDSGAILAMDYKKSVFYSGNASFLDVIKNCLSINLSYAEISELYKNVQLQVIHQPGEYFRFENFTNDIKDLQVKSMGEYFQNQYDQIIEMEYKAVMVHPKCVYLLETLEIVPDQKISKEKLSTLKLDTKNLSIKKRLEGIKNQYANMQFNNVITEAFGINVSTEMIKAEYVQLSVPCIIAGDNKSINPNEDGTFRFDRDHSYCEIASIKNLFVYGCPEKWKQILQKQLKERKITVENIYCNNNPKDISTFEQWKNKLAKIDPSVDYVIVITKTQDIHDLLNLLQIKTGIRIQHILEATTQINACIFNIIHKMNHKAKGFNWKVGFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y589</accession>
    <name>A0A914Y589_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y589"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15366.t1">
        <property type="protein sequence ID" value="PSU_v2.g15366.t1"/>
        <property type="gene ID" value="PSU_v2.g15366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044714">
        <property type="entry name" value="AtSIBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46672:SF1">
        <property type="entry name" value="OS08G0103600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46672">
        <property type="entry name" value="OS08G0495500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="50"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15366.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24952" checksum="9DED8AA2AEFB1DD3" modified="2023-02-22" version="1">MKDILNPEKNFIENGKFKLQMKGIFFCDKSDEKQIFQTTLGQHLWERDDRDFVISVGKNGEDKTEIKIHKLILASRSPVFDAMLKAEMKEKVENRIEIVDFGVEIVEAAVDFFYDQESYVMLDLDNLIGLLQFADKYDVKDLKRKIENQLFDLLHPTNICQIVNASIISNSQMLKDICLSSMIVFHCQKVLIENLEILDKDFAFELVQKSFSSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5K4</accession>
    <name>A0A914Y5K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 129</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM129 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5K4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1452.t1">
        <property type="protein sequence ID" value="PSU_v2.g1452.t1"/>
        <property type="gene ID" value="PSU_v2.g1452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018801">
        <property type="entry name" value="TM129"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31322:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TM129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10272">
        <property type="entry name" value="Tmpp129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1452.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43858" checksum="8F73EC946BD4AA66" modified="2023-02-22" version="1">MELGLPASDIFLSAAIFLLAVLVIVYPPAEARSAGFIIPNIFYSIVGDEKFDFVRHHLRRSCLTILIQALLPMVYTFVMYFYFYEEFTLAGSFDLVKLLFRFSSTVLLIAAGYIFQISRSNFSNHSIIKNLAKYGIVNDVASQINDEIKDILNFKVEYVGYSKLIITSSWIIKVTMYNVVFLKISDARFKLVRTLDHPILFQENSGKQIIDVEAESISGKTKPVIIRVYSREMFEELRQKLGGNVEIVTDIRFKSSLHERFVTVFKQHINNNPKYNYDFKYELEPCLGCQSVESNIKLDKTCMDSVGQVQCRQCHCKPMWCTTCIAMIFASKQNDLQPEQWLSGRAECPTCRALFCVLDVCLLSSSSLPLPPSEDQTNNSTTATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y609</accession>
    <name>A0A914Y609_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y609"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14880.t1">
        <property type="protein sequence ID" value="PSU_v2.g14880.t1"/>
        <property type="gene ID" value="PSU_v2.g14880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF159">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14880.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32922" checksum="CF70329EB4B653D2" modified="2023-02-22" version="1">MNQPLTNYWIASSHNTYLTGDQIKSDSSLDAYANSLMMGCRCVELDCWDGGKKNNGEPNDVVIYHGYTMTSKINLRDVLYTIRHYAFVTSEYPVILSIEDNCSVPFQRLMAQEIKDALGDSLLTSPYSKDETHLPSPAALRKKIILKHKKLQLENNNNADDDDQDILSKESVKRGMLYLRDNTHYTWTRHVFVLFDDKICYVLNPVDSDALTNRKEDMGDEDQQDDISMKGFGVRPEEMHVTEEWYHGNIDRKVAEKRLLEQKDKGEGIFLVRDGGTFIGNFTVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y734</accession>
    <name>A0A914Y734_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y734"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15264.t1">
        <property type="protein sequence ID" value="PSU_v2.g15264.t1"/>
        <property type="gene ID" value="PSU_v2.g15264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15264.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8096" checksum="FBCBCAB0468D6392" modified="2023-02-22" version="1">MILVVDWLLKLNVRIMLSELTVEIVRNSGSPKEDKLVVCTKEAAADAKDAMAIFKAGEANDMQTVALHADAIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7H7</accession>
    <name>A0A914Y7H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HOOK N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7H7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13571.t1">
        <property type="protein sequence ID" value="PSU_v2.g13571.t1"/>
        <property type="gene ID" value="PSU_v2.g13571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13571.t1"/>
        </source>
    </evidence>
    <sequence length="446" mass="52045" checksum="FADEE29BCC24BFF9" modified="2023-02-22" version="1">MDDDDTFIKKILIWFSRVSCHQDDVTTEGLYNGTVLADFLSTFDIEFFDEKWHDSIVFSDHNNSSSRIASVSSVASKVSDYFLLKLSRHLNGALKWSVKPESIAIQEDRHELVKLVITVIFASGTNAMLMGQLNDVFNESELQKIAEKLSVLNTDVPTVCEDDRWLILHLIEKHKNEKEKIEKEKLILTKQIEDLVEGKQHLEDEINQMHKSYDELSYKCDSYVGMIEQQKKRDNFSLNSEKQISILEKEVEKLQLQNRAFENEIQEKAMRISRLQDESIEIVSNYRELEAELTRAKTSQSRLSENKTESKEEEFLRKRIENYAAECSKLREQLLDMETFKVQSTNLQFINDDLEQRISELVENSHQMLADNSRLKRRLEELERSPMLSTARERYSDSPPSLLETINNNGTTNLYEEKLEEIEKENATLKAKLDNIERKRTNMLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9G4</accession>
    <name>A0A914Y9G4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9G4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16839.t1">
        <property type="protein sequence ID" value="PSU_v2.g16839.t1"/>
        <property type="gene ID" value="PSU_v2.g16839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16839.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29302" checksum="5EE4580135338EA3" modified="2023-02-22" version="1">MHHQYRGETVVATPMASHHHHWGQPLCASNITTVNAGSNKKRDFHFQVISVDQGPKWFVWPSNKSVDQPETNSSKNSSNQENENHYHKNGAISPNTVQPNAPMTINVAHLQRKNRLSRRKQLADMHHHCSVVDGEYAHVTATNSATDAPLSEPLARRLLSKPIICVTPSQESSPSCSSSMPSQTFKILSVSKKSWESEDEDESTTTTTTCSCRKMSLSLDDDCELPSRAHCAAVSGSSISSYISTASSSSSTSANSNDSGVCNGANNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAD5</accession>
    <name>A0A914YAD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAD5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17166.t1">
        <property type="protein sequence ID" value="PSU_v2.g17166.t1"/>
        <property type="gene ID" value="PSU_v2.g17166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF287">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17166.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="28212" checksum="8A31F7B5D5F58617" modified="2023-02-22" version="1">MKVEYDKKRLEEAESFRKLAFFGITVSSIATIVAILVIPSLYNYTQYVRSTLETEIDFCRHRSSGLTQEYQRVSPIHKRQAGYDSAVVNTPTASGGINADAGAHCCSCKVGPPGGAGEAGVDGHDGTDGMPGEPGKNGADAAPDAHPTAEDFCFTCEESPAGPPGNAGPKGAPGNAGSDGEAGKAGAPGQVGPAGPAGPSGEAGKAGENGPAGEAGTLNDVPGTPGPAGPPGAAGPAGENGQDGTPGKPGEEGAPGPAGDSGAPGPKGQDGQNGSPGELVFQLLLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAF3</accession>
    <name>A0A914YAF3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAF3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16410.t1">
        <property type="protein sequence ID" value="PSU_v2.g16410.t1"/>
        <property type="gene ID" value="PSU_v2.g16410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16410.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14340" checksum="4C5E69AE2923B536" modified="2023-02-22" version="1">MVNNYNIFYICPKLFSYRSLFYPDSLRQWERNRKQQAERTILTAAKIISPRIASTFSDGYAWCVEAIKQSVYSSLAIELEINKAADLLKLGDVDAATEALIAFNNKESKVGSAAANNLALINFYVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAS7</accession>
    <name>A0A914YAS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAS7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16388.t1">
        <property type="protein sequence ID" value="PSU_v2.g16388.t1"/>
        <property type="gene ID" value="PSU_v2.g16388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF312">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16388.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38538" checksum="D4E5FC6DF17F57CE" modified="2023-02-22" version="1">MIITLNYLGEFFYKSIADIVKYFNTNCFKNSFKKKREDQVQKKENGRNVASKKSEKNQNCRKESENNNNNNTIDQNSMDTEEIGGTDDLIKGDSNEGIMNSVEEGKVTIPIKVALIITIGWVFFCAALFQLWEDWTYGESWYFMFISMMVFCFVFVIVGLSLVSMCFNVIKNALKDLYKQMLMKLLTEYHAAMSEGGDQKSASIKMMKNWGKSQKDQLLIKLTNKNRRNKVMNEIKEMAKDAGIELPPIFESLNGAKNKLFNASKDDDKNSGTMSMIDKESNSSKISNKSPSTTVVRRDAITQTDICLLNKSNNKKTISSESANSGVQREEGLSTILSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCE3</accession>
    <name>A0A914YCE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17091.t1">
        <property type="protein sequence ID" value="PSU_v2.g17091.t1"/>
        <property type="gene ID" value="PSU_v2.g17091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17091.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11914" checksum="8F8B2B9110C65A30" modified="2023-02-22" version="1">MKYIFVITVFAQSSPKKCDVISKNFVIFFNFNIFSFNFWPKIYVLQIEREFDFESTECFAPLLLISVYSAIISAFLGAIAVAIVWCLKCSLCFDQKIPENWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEN6</accession>
    <name>A0A914YEN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fimbrial-type adhesion domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEN6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15854.t1">
        <property type="protein sequence ID" value="PSU_v2.g15854.t1"/>
        <property type="gene ID" value="PSU_v2.g15854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1090">
        <property type="entry name" value="Fimbrial-type adhesion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2610">
        <property type="entry name" value="Outer membrane usher protein FimD, plug domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000259">
        <property type="entry name" value="Adhesion_dom_fimbrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036937">
        <property type="entry name" value="Adhesion_dom_fimbrial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042186">
        <property type="entry name" value="FimD_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011746">
        <property type="entry name" value="PRK15199.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="OUTER MEMBRANE USHER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451:SF6">
        <property type="entry name" value="OUTER MEMBRANE USHER PROTEIN SFMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00419">
        <property type="entry name" value="Fimbrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fimbrial-type adhesion" evidence="1">
        <location>
            <begin position="435"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15854.t1"/>
        </source>
    </evidence>
    <sequence length="583" mass="64782" checksum="76FB7656DBC3682B" modified="2023-02-22" version="1">MGYRYSTQGFYTLDDVAYRRMEGYEYDYDYDGEHRDEPIIVNYHNLRFSRKDRLQLNISQSLNDFGSLYISGTHQKYWNTSDSDTWYQVGYTSSWVGISYSLSFSWNESVGIPDNERIVGLNVSVPFNVLTKRRYTRENALDRAYASFNANRNSNGQNSWLAGVGGTLLEGHNLSYHVSQGDTSNNGYTGSATANWQAAYGTLGVGYNYDRDQHDVNWQLSGGVVGHENGITLSQPLGDTNVLIKAPGAGGVRIENQTGILTDWRGYAVMPYATVYRYNRIALDTNTMGNSIDVEKILAALCRRKARWFVPIFDTRIGVRALITVTQGGKPVPFGSLETIDNYKYMQLHDYLLGAMSLVDSVMDIQFPPQNYIRMGTDPNVSQNLPFGVMDSRLIFRLKVIRPFINMVEIPRQVMFTVYVTSTPYDPLVTPVYTISFGGRVEVPQNCELNAGQIVEFDFGDIGASLFSAAGPGNRPAGVMPQTKSIAVKCTNVAAQAYLTMRLEASAVSGQAMVSDNQDLGFIVADQNDTPITPNDLNSVIPFRLDAAAAANVTLRAWPISITGQKPTEGPFSALGYLRVDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEU4</accession>
    <name>A0A914YEU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP synthase F0 subunit 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEU4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1879.t3">
        <property type="protein sequence ID" value="PSU_v2.g1879.t3"/>
        <property type="gene ID" value="PSU_v2.g1879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010876">
        <property type="entry name" value="C1orf43"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07406">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1879.t3"/>
        </source>
    </evidence>
    <sequence length="257" mass="28997" checksum="CBE6B4A4EE201D08" modified="2023-02-22" version="1">MIPATLGLGGYTIVFAVAFILLVLIAGTIVVFRQIQRVRLNSARREINSSIAPETSKKHREGILSKINAVAAFRQSYFPKFTDCNMISERLKTFAENFYATKSYVQRMIGFDEINRSVDRQLEFINPHIVRSPGQSTYAFLKELREMANLTELDENFIERLSFLHESCRFRTVVPFGDEHLEELRGILKEFLKILGNNQAHLSSISPLTGKAQNNDGGRRPSAGITLRRGIRSQKGTKMVEEIPLLHVGGIVDKGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF91</accession>
    <name>A0A914YF91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF91"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17426.t1">
        <property type="protein sequence ID" value="PSU_v2.g17426.t1"/>
        <property type="gene ID" value="PSU_v2.g17426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17426.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14068" checksum="F35D756A6DFCB6DC" modified="2023-02-22" version="1">MSIVDELLANSFVKIRNPSDVEAKLHKIIKDGYNNLMILADFDYTLSKFKDLNGKECLITHSIFVKCTQEVKPELSEKLKVICNKYGPFEHSTKISREEKISKMEDWWYSLNYPKMIFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFJ0</accession>
    <name>A0A914YFJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFJ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18216.t1">
        <property type="protein sequence ID" value="PSU_v2.g18216.t1"/>
        <property type="gene ID" value="PSU_v2.g18216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015716">
        <property type="term" value="P:organic phosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017797">
        <property type="entry name" value="Phosphnate-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03431">
        <property type="entry name" value="PhnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35841">
        <property type="entry name" value="PHOSPHONATES-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35841:SF1">
        <property type="entry name" value="PHOSPHONATES-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12974">
        <property type="entry name" value="Phosphonate-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18216.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25271" checksum="A6301D7597C0F669" modified="2023-02-22" version="1">MEKKLGVKVNAFFAPDYAGIIQGMRFNKVDIAWYGNLSAMEAVDRANGQVFAQTVAADGSPGYWSVLIVNKDSPINNLNDLLAKRKDLTFGNGDPNSTSGFLVPGYYVFAKNNISASDFKRTVNAGHETNALAVANKQVDVATNNTENLDKLKTSAPEKLKELKVIWKSPLIPGDPIVWRKNLSETTKDKIYDFFMNYGKNAGRESGAGTPGLGAVPRLQRPATGADSPARTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFN5</accession>
    <name>A0A914YFN5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Beta-1,2-N-acetylglucosaminyltransferase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">GlcNAc-T II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mannoside acetylglucosaminyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12941"/>
            <dbReference type="Rhea" id="RHEA-COMP:13526"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60651"/>
            <dbReference type="EC" id="2.4.1.143"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 16 (GT16) protein family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.143" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YFN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17572.t1">
        <property type="protein sequence ID" value="PSU_v2.g17572.t1"/>
        <property type="gene ID" value="PSU_v2.g17572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008455">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007754">
        <property type="entry name" value="GlcNAc_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12871:SF0">
        <property type="entry name" value="ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12871">
        <property type="entry name" value="BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05060">
        <property type="entry name" value="MGAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17 24" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="338"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17572.t1"/>
        </source>
    </evidence>
    <sequence length="479" mass="55569" checksum="5FA4D2A5F2611144" modified="2023-02-22" version="1">MFLPSTSMAFMRKVNRCLTVILAISFFCLISIFLTTPPSNIDNGRPYDFSTLNGSHNAPVISALPLNSSKFDDPAQWKNIFHVPSEFEDIVESIEYLNYHHEIQNEKRFGSVNQSTFVIAVQVHQRLEYLKNLIATLKNVKGIENVLIIFSHDMNFEPINTAIKNIDFCRVIQIFYPYNIQIFANIFPGQHPDDCDSSVNAKEAESLKCQNWRFPDKYGHYRIASFSQIKHHWWWKTNYVFMLMERYHLDTYTVFLEEDHYVAPDMIHVLKILIEKKDKFCRNCKLLSLGFYLKNFNNYRNDINKLGVHTWFSSKHNMGMALNATVWKEIKECAKLFCTYDDYNWDWSLLAISVKCMKEKMRVITLKSPRVIHVGECGVHVHHQADCNKAVSAASALFQQVSDALFPETFVVSEISKRMLKPSKPNGGWGDPRDQELCLMNTYPIEHGTFLPSVLLNFSSILPPFDRSINRTNVESNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGI1</accession>
    <name>A0A914YGI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGI1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18558.t1">
        <property type="protein sequence ID" value="PSU_v2.g18558.t1"/>
        <property type="gene ID" value="PSU_v2.g18558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Protogenin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="131"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="235"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="349"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="441"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18558.t1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64780" checksum="2F936FCDE839FD39" modified="2023-02-22" version="1">MSFELQQKIELALVNQLQNFVLQLQKNVKALPSRVRNLRASISADSVEILWDPPIDNVDETIRYKLFYVRKDRQSVEEETQAHMTKTSYILHDLDKDTEYVIRIEAFTTNGGGPTSESIIIRTLTDIPSKAPENVKAEAIHSGSLKVSWQPPPASDRNGAITGYKIKYKSHHRGSKASIAVVEGDPGEYTLNGLESGTPYVVRLAAINQNGTGPYTDWVKAQTLLDDLQDSILTAPRQLKVHATHDSIYMSWDPPMTEGIIIRGYEIGWGPGVPDQEKARVEAHIRSYTIKGLKPSREYVVALRGYNNAGPGFPIYETIRTTSYGYGSMPPSNTHSGGALSNPHQPSVTPLGIRAESESSSSIRLSWTDPSDIFNPFYTVRYSSSMDNNGSPRYVNTSENEITITDLRPNLLYEFAVKLVDSQHWSMAVSNKTEPAAPSSSPRDLTVIPPTKGRYVDPNTVTLNWQPPKYANGEISDYSVLYTHRPEQDDKEWLVDSVRGDQLSMTIRNLVPQVYYFKIQARNVKGIGPFSSIVKYEPDGYSASRANIRYRTSENSTIFTKLYELWEYVFPPPLFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGI3</accession>
    <name>A0A914YGI3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L27a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGI3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19413.t1">
        <property type="protein sequence ID" value="PSU_v2.g19413.t1"/>
        <property type="gene ID" value="PSU_v2.g19413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19413.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16419" checksum="971B81492410C06F" modified="2023-02-22" version="1">MATTKRKCRKLRGHVSHGHGRVGKHRKHPGGRGNAGGMHHHRINFDKYHPGYFGKVGMRNFHVRANQLYCPTVNLDKLWTLVSEETRKRYAGVKDKAPVINVLNAGYHKVLGKGLLPKQPVIVKAKFFSHTAEQKIKKAGGACILVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGU5</accession>
    <name>A0A914YGU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pertactin central region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18014.t1">
        <property type="protein sequence ID" value="PSU_v2.g18014.t1"/>
        <property type="gene ID" value="PSU_v2.g18014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004899">
        <property type="entry name" value="Pertactin_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03212">
        <property type="entry name" value="Pertactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pertactin central region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18014.t1"/>
        </source>
    </evidence>
    <sequence length="421" mass="42875" checksum="BBFC73EE94713275" modified="2023-02-22" version="1">MTPAGNTPGNINLGNDVTVNVNDASGYAKGIIIQGKNSSLTANRLTVDVVGQTSAIGINLIGDYTHADLGTGSTIKSNDDGIIIGHSSTLTATQFTIENSNGLQRHGDKRTENSVVDLGTNSTIKTNGDNAHGLWSFGQVSANALTVDVTGAAANGVEVRGGTTTIGADSHISSAQGGGLVTSGSDAIINFTGHGSATNSIFSGGSYGASAQTATAVVNMQNTDITVDRNGSLALGLWALSGGRITGDSLAITGAAGARGIYAMTNSQIDLTSDLVIDMSTPDQMAIATQHDDGYAASRINASGRMLINGSVLSKGGLINLDMHPGSVWTGSSLSDNVNGGKLDVAMNNSVWNVTSNSNLDTLALSHSTVDFASHGSTAGTFATLNVENLSGNSTFIMRADVVGEGNGVNNKGDFIEYQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHB4</accession>
    <name>A0A914YHB4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YHB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19710.t1">
        <property type="protein sequence ID" value="PSU_v2.g19710.t1"/>
        <property type="gene ID" value="PSU_v2.g19710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19710.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29754" checksum="A46CC2276B7BBD19" modified="2023-02-22" version="1">MFCSGTAGTGKSFLIHLLANELALLYVKKEDSASTKPATLIAAPTGLAAIQINGSTIHSLLSINVQHGSEGKMKPLSKEALNLKRILFQNVKLIIIDETSMVSNIMLAKIHSRLCEFMDKNELFGGANLLFFGDLLQLPPVKSSPIFKLLQPYQLKKVFDSSVPPFSFWECFGYEELTENMRQKKSLEFAEILGRMRVEALTQADHETLRSKIIKTPNGGLPNLEQLVEKYIEVREKNPTVMALFACTDEVTMFNNEVTKQLNLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHH0</accession>
    <name>A0A914YHH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19777.t1">
        <property type="protein sequence ID" value="PSU_v2.g19777.t1"/>
        <property type="gene ID" value="PSU_v2.g19777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19777.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11168" checksum="5C604A769D4A82E5" modified="2023-02-22" version="1">MASTARKDSAALVSLLKNNEENDEEEEDQKITDNQLQLPATRKESKVVTALRKFNQIGTNIEEIRKPQFPGQQDSRPYSFAKNDYTCINLRVNIQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHU2</accession>
    <name>A0A914YHU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHU2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19899.t1">
        <property type="protein sequence ID" value="PSU_v2.g19899.t1"/>
        <property type="gene ID" value="PSU_v2.g19899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038138535" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19899.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="9791" checksum="E84BDC2425A06493" modified="2023-02-22" version="1">MKHPILIAALLCGAAAPAFAATCESNFQKKGNPFVGTTFTSSVTHPDLTVASAIGQMRVIAKNANMDVLSEDVEGGSMLIEEPEPWPTSRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK19</accession>
    <name>A0A914YK19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20689.t1">
        <property type="protein sequence ID" value="PSU_v2.g20689.t1"/>
        <property type="gene ID" value="PSU_v2.g20689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20689.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7814" checksum="9E755A11DE02A34D" modified="2023-02-22" version="1">MCSKENFEFGVDSGVDSIDSDSGVDSSDSDSDSGVGVQDQYRYLDKRRITMINHCLEGLERGDWIFNADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKF4</accession>
    <name>A0A914YKF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKF4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19355.t1">
        <property type="protein sequence ID" value="PSU_v2.g19355.t1"/>
        <property type="gene ID" value="PSU_v2.g19355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19355.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26139" checksum="14EDB5DBF81FCFCE" modified="2023-02-22" version="1">MFQQQSAALKKEEQEIDAIKQNLFRENDIKEETEPSKFSPLNYSSQIKTSIEEYEELIDEIDDPIISDENDDDDDEDADEYKDVLLEIAQTKIRKLENEIFHLKASARDDDKYIAELEGDIRNLENSLKKLQSPKREIEFLQNQVENARHQYFNLSSEYRQKDQENQQLREIIANFQGSKTSESATSMLDTVKTTSTTIDDESMDLSNPSTSSTAAAANVVNVPSKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKM7</accession>
    <name>A0A914YKM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20083.t1">
        <property type="protein sequence ID" value="PSU_v2.g20083.t1"/>
        <property type="gene ID" value="PSU_v2.g20083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20083.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="28968" checksum="140643DBF3687F95" modified="2023-02-22" version="1">MATRGKFSSFKDRHKTFAKDRVQISAINFNQAQKSSTISIVHSHSKSLNNDKKFDIAAYENSIEASAASGSDSDERDGLNNQKGKSGFATTLETLKQFFNGQPASIQNPFEFPRQQGENQASEPAVMQFKASQRLLNPNQMDPTGTKRTADNNSNIYETPKKKCNPADARASNLGSSSSFTGLQTPVTPVTPATSTAKIVQSLSLGSTPSSTSTTPSKSKRKSSTGSKKIDINDYDPAMLAEMEPYLTGVSSKDFDADALVSLDTFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL66</accession>
    <name>A0A914YL66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YL66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20285.t1">
        <property type="protein sequence ID" value="PSU_v2.g20285.t1"/>
        <property type="gene ID" value="PSU_v2.g20285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF3">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20285.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="41829" checksum="0688A8C7FEE9B9D2" modified="2023-02-22" version="1">MDLNGDSTFGFNAAAHLIGALDTTVPTATAQGFYDSSQFHCSSFPSAYGSTGFAHLPTFHGHDTFGTLPPLSFTGSTFSSQQGTSSYLNDLNTLTSTQIIAPSATAPTITTNKKTAAEKKGNTKKNIKNEPSMKSANSMMLQNQKVRRQRTHFTSFQLTELESFFSRNKYPDMATREDLASRITLTEARVRVWFKNRRAKFRKREKPLLQNADMRSISAAAVAAATGTQALAAIFEENASVYQTSSWSTPYSTTIVPRQPATNTTATFQWNHQSNHPGNNNNLDITSTSPNSAATLPAPISVYSPLPASGSSTNSSLNRSPLHIGTKVTMDNNNVTHFTTPNLIPTSMQNAFNCTDYFSPYIHSPGSFASPIAFSQYNPYHSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL80</accession>
    <name>A0A914YL80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20299.t1">
        <property type="protein sequence ID" value="PSU_v2.g20299.t1"/>
        <property type="gene ID" value="PSU_v2.g20299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20299.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13259" checksum="88F44DC0B090776E" modified="2023-02-22" version="1">MDKPVPPAQMDNLVPQDNLLEVDHLAHPDLLEMLDQTETPELRDNLVIILNHLSLTCWKRWTTWSPGPNGNPGSAGAPGGPGPAGPAGNPGAPGGDGQPGSAGGPGLPGSDAAYCPCPPRSAVFLSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLF0</accession>
    <name>A0A914YLF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLF0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20375.t1">
        <property type="protein sequence ID" value="PSU_v2.g20375.t1"/>
        <property type="gene ID" value="PSU_v2.g20375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664:SF8">
        <property type="entry name" value="DUF4440 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664">
        <property type="entry name" value="PROTEIN CBG16427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20375.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12410" checksum="8D978DCA6CAF08B9" modified="2023-02-22" version="1">MRAFNEGNAAKAAEIYSPDGVFMPNSSQPLRGRKDIETYFKSDMTDGVATAQIITEEVKGCDCEKFAYERGSYHLNGKKGLESGTYLQVWKKENGVWLVQSDCFNVTKPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMJ6</accession>
    <name>A0A914YMJ6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 2 subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMJ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20807.t1">
        <property type="protein sequence ID" value="PSU_v2.g20807.t1"/>
        <property type="gene ID" value="PSU_v2.g20807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="4">
        <location>
            <begin position="77"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00042452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20807.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15022" checksum="824CCFF934E63487" modified="2023-02-22" version="1">MDDEDLVLVLPTRKPPKRRPKPVPEDPSIAAEAAAFELGRMNIIDAKKDWPDYTYEELLGIAFGIIRDKYPDLGGDKKKFVMKPPQVARAGSKKTAFTNYAEICKLLKRQPKHVLQFLLAELGTTYDFIHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMW1</accession>
    <name>A0A914YMW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMW1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20274.t1">
        <property type="protein sequence ID" value="PSU_v2.g20274.t1"/>
        <property type="gene ID" value="PSU_v2.g20274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20274.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33803" checksum="F8B84E685CC9CE66" modified="2023-02-22" version="1">MECTHANPVKMEPEEDLKDILVHDEPSSTSVADIKPIILKLQENEEELEEIDIMGTSDNEESAQMSSSNGSVGPERNGNRNKHRVSFAHPAAASSSSSIRMNPPTRVAIPANVVKSQITKKPTRTKYVKDVNKKDMTFNTQQDYNYMDDELFFKKEEIPLPFEDVRLYEHGLEQRPLGEQRYVVDAIANAFNVLQHEARRIQGQLRALNARSGRIRKQIDREEEAIARGEDPTEVPRSSKGLLEGELMMPVKPAPRPPQSSHSRRRKKIIRRRPQTSNTGAAGNNKLAGSGQHDEDGDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMW2</accession>
    <name>A0A914YMW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18668.t1">
        <property type="protein sequence ID" value="PSU_v2.g18668.t1"/>
        <property type="gene ID" value="PSU_v2.g18668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18668.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18073" checksum="05C7E3DF4FCDE5CD" modified="2023-02-22" version="1">MSQGKVLVEFKKANGGDIEVSEEKFLQSKMCCGTPKQSPGREMSPDVFSDITEPFSDMTNRYPYDPPKTPFIIQNTAKFKPFTPPTISAELRKEMVAKRNSERKRKAEDELPIPSTPAATFIPTASPLITPEMRERSRRNREAALAKRKSLQSNQSFNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNY2</accession>
    <name>A0A914YNY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M13 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNY2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21136.t1">
        <property type="protein sequence ID" value="PSU_v2.g21136.t1"/>
        <property type="gene ID" value="PSU_v2.g21136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF192">
        <property type="entry name" value="NEPRILYSIN-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="131"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21136.t1"/>
        </source>
    </evidence>
    <sequence length="489" mass="56507" checksum="8E996A4D990C7E0A" modified="2023-02-22" version="1">MKSVADSTEGNSWSSQKKGCFASFSRLEVSLITISSILFALLSGICTFWLFYLDGYHIFEEGISSWKQRNPLFFSPSNKSIGYDPLAYNHNRLICTSRECANIAAFFATNLNEKVCDYFFLYFRHTIIDTQTLLHKQIKQILEAPIAKADKPWDKLAKDYYAKCLNEDALVLDGKTSIRTLLRKIGGWPVLEGNKWNEFEVGWEEYTAIVLNKTGVTAILFELTVSHDPNNSSKTVLEMDQPKFGIGSRWPYTGGINDSMVRNYTELMIQTAIRLGANETTVRAEMLEAVELEIKLVDYSSDETIRRDPDRSNNPYQLWQLKQHFPYIDFEAFVERVFDGIVNISQNDTIIIREMDYFKSIQHVLKSSSKRAIANYVGWRIVQGFSPFLPPRDREPFYEFKANQTGLFNVPVPERWEDCATLSIMLLDMPVGKLFVQNFFDEKFAMPKMTEMTTYLKKTFIAELEDLDWMDSATKERAIKKANAIQYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPM9</accession>
    <name>A0A914YPM9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nitrilase and fragile histidine triad fusion protein NitFhit</fullName>
            <ecNumber evidence="3">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves A-5'-PPP-5'A to yield AMP and ADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the UPF0012 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YPM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19314.t1">
        <property type="protein sequence ID" value="PSU_v2.g19314.t1"/>
        <property type="gene ID" value="PSU_v2.g19314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000005">
        <property type="entry name" value="nitrilase homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="403"/>
        </location>
    </feature>
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        <location>
            <begin position="388"/>
            <end position="392"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <position position="321"/>
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        <ligand>
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        </ligand>
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        <location>
            <begin position="383"/>
            <end position="386"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="13">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19314.t1"/>
        </source>
    </evidence>
    <sequence length="440" mass="49591" checksum="78AA3CFD74AE8BCD" modified="2023-02-22" version="1">MQTQRVFRQVVTNPLVAVCQLTNTHDKTRNIEKAHELISKAKDHGCKMIFFPECADFIGRSKDEVLKLAESINGETMKSFRELAASNKMWISVGGFHNKKSEDILPANTHVIIDDKGQIVVQYDKLHQFNIDTPKVRLLEREFSSAGNELHSPVETPVGKIGLNICYDVRFPELSYFHRQAGADILAFPAAFTVPTGMAHWEVLLRARAIETQCYVVASAQYGKHTDTRSSYGHAMIVDPYGKVVAQCSDREGLCYAEIDLNYVKEVRQGLNMIGDRRGDLYTTYYKQKFPTKGVDGIFADKTIPAASIFYRSRLSFAFVNLHPLVPGHVLVSPNRVVQSIKDLTPAENADLFNSVQTVSNAVLEYYKVESSNVAIQNGTDAGQTVPHVHVHIIPRKHKDFGDDTDNMYKELAEHETKRPQQTPDQMAEEASIYRKLLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPP8</accession>
    <name>A0A914YPP8_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g2797"/>
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    </dbReference>
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            <begin position="121"/>
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            <begin position="184"/>
            <end position="215"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2797.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45064" checksum="BC30DEE55AC2ADC7" modified="2023-02-22" version="1">MTLSTTATSKASHLNIMADPRVFRGSVVARQREEINRCRQEIEARKAEERYRMEVVRNRLSMALSHDIPKPNPISYQRAANIRAETSARLAKLAGKTGKAAIAEWATKESHHINSLLMNDEKGIDHSPRKSAPRRLSPISSNNGRRKKMIPTIESPKINGFHRIQKNDVKNVKKNLKNVRFIPLKNESPRNGPHKVVPSIPFSSSFDEKRQNRGGRRRFHRPFLSTTLTPLQSPYGPIYHNDASVQTDEGFEEAFCPIISEMAATAISDALKNLKDEEDFKIMEEQNEKLLNVVVSEKRRNSELNLSILKHIRTEHEIAREREMAWHQLKAIDSHQMATQLISNLIEKCTENLADHGLIEDTCKVRSVGADTRQLEKHQAELKAASLGRIFSIPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPR6</accession>
    <name>A0A914YPR6_9BILA</name>
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        <submittedName>
            <fullName evidence="5">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A914YPR6"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008061">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
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        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038123200" evidence="2">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="219"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21009.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31350" checksum="175048EAA0A8361B" modified="2023-02-22" version="1">MVKWFISLLTVAALANAGYTGPAAEAPVLPKNVAPPMHQPQQSYVPQSPPQALPQEHPQVYAPAPAPAQQQPQVYAPAPAPAQQQPQVYAPAPAPAPAQQQPQVYAPAPQPQQPYNQPQQTPARPSFDCRTKSDGLYELGRCQTTYVQCLYGEASLATCPANLVFAKDKCDYTNDCLNPTQPPPPPPQQQQPVSGYARQQQFNKYSKPMVQQAPPKPVETFCQQNNLFEGYHAQGCSHDYFACFPLHTLRLNCPANLYYDIEMQQCDYRHLIKNCGGHRPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ26</accession>
    <name>A0A914YQ26_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ26"/>
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        <property type="gene ID" value="PSU_v2.g2922"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2922.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27053" checksum="E3E5DB9C00D2B5FE" modified="2023-02-22" version="1">MSPSTEVAPTEISLKDTETIEKPKLDDAQKKALVDEKTTTTSTDLLFEKPHIYQGLEVEIYAEELEDVESKVSSKMQKDEKSETGSKTKEEAEEKAAEISIDTAQKSADLSEAISAETKSEAKEVKTDVEEQKEKSQMEQKVTVDSKDAEEVAKIQTDKEAQKSDAVKPEESKTPAETVPATTEETQISVTTAPETKSDAVKTEESKTPAETVHATTQEAQIPVTTAPETESAAVKPEGSKTSAETQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ35</accession>
    <name>A0A914YQ35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A914YQ35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2933.t1">
        <property type="protein sequence ID" value="PSU_v2.g2933.t1"/>
        <property type="gene ID" value="PSU_v2.g2933"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2933.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10991" checksum="44D9224355547DA3" modified="2023-02-22" version="1">MEEILESCHVVPTAPDFTDCFPYSRKDGTDPLALDSLPQCFFCRKSKRICGTKVVDFGKGRKVRLISIPKYDETHSMVIINLRTLETSTIVSKHCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ65</accession>
    <name>A0A914YQ65_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YQ65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21171.t1">
        <property type="protein sequence ID" value="PSU_v2.g21171.t1"/>
        <property type="gene ID" value="PSU_v2.g21171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF154">
        <property type="entry name" value="GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21171.t1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56624" checksum="0B685EDAFA7503BA" modified="2023-02-22" version="1">MDSGARRKLKVLYYIPSLGYSHVQFNGKLAEALIDRGHEVHLLMPEVDPSVGTFNGTTKAAKVFRFPTPGLEAFKNPKLVSNYFDGSYFAFTKGAKQFWLDMVYFGCKTTVEQKELLDSLKSENYDIGIGEALSYCPFALFHYLGISPTFSTTAIPIQTFVTENFGLTHLPSFMPIIGEAIINGENLNFMERLKNLYIRYCEYSVDSKVYQRETQLFQKHFGHGFPDSRNLLGNVSYAFTNAHPMLSFSKPITNKVVYLGGGAVPKAKALTKEFEEIYSKAKKGVVIFSFGSLVNTKRLSEFKHKAFVDAFERFSDYEFIWKINSETEDLAKSLISSSNIHLVSWIDQISLLNHPKTKAFITQCGLNSVNEATYTGVPMIAIPLFADQFYNAAVVKHKEIGAVINIGSMKSHDVEVALHEILHNPKYKKNIDIVKRKLELYPFNPLEEFVKRVEYAAEFDNLNELNLASANLSFFKVYYLDIIGTIFTVFAFIYFCLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQC5</accession>
    <name>A0A914YQC5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3013.t1">
        <property type="protein sequence ID" value="PSU_v2.g3013.t1"/>
        <property type="gene ID" value="PSU_v2.g3013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="255"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3013.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36540" checksum="66017E5A9D5D0483" modified="2023-02-22" version="1">MSSINSISFVQHSSDPVASRVWGLNWNSTGKNLVTCGEDKSVKIWKLNSEKLELIQKIAGDQTRAIRYAHFSSCGKYLATGSWDATVIIYEYVGNEFEEKHKLEGHDNEIKCCQFSPSGAYFATCSRDKTVWVWEVDEDGDYEVLSILQRHSGDVKFVLWHPEYDLLISGGYDNALRMYYYDGDDWVSAQDIEGAHGSTIWSASFDPSGRYMVSVCAEHVVKIWELTSPMPTSSAKLLNIASYEIKDTVWPLYSVSWNPLNNLIAIGGGDQYVRLLQFDEESKAVLPFLSLKLDSEINSLSWNPTNDSLLAAALDDGTVQLVNVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQF5</accession>
    <name>A0A914YQF5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylinositol 4-kinase beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:19878"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Rough endoplasmic reticulum membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQF5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2260.t1">
        <property type="protein sequence ID" value="PSU_v2.g2260.t1"/>
        <property type="gene ID" value="PSU_v2.g2260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="583"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2260.t1"/>
        </source>
    </evidence>
    <sequence length="837" mass="94574" checksum="386FC4F7A1D36A89" modified="2023-02-22" version="1">MFGRQPVDECNHSSTGLCSKCVLRDTFNLSTESADSAQNASYFQQNNTSTTILSFDELLQLTASSSSGTMPKFLPSSYPNQSPATKRATFSFEEDQEHQSPTESAEEELFKESDDIPTEEMVADAGYTSLASINSSQRRITEGDETDESAFLAVKKNLQEKQSLLLRLFESPHFDINLAMKYLFISRETGILSYLGNFPPNVVDFYLPQLITLYINMPNVAQALHCYILKRCSKSVMFALECFWLLEAYDVELFRKQSNKVHGYHLRQKILQDFLSECSSRPNSRTSFHTRSKSDAKVANGVHPSPTTMPRSDSAASVRSIQGAPGDLKTGKAFDDGCCCTSENEPFECICVSNSKIRPEMEFVKALMNIGNKLKFIPLKSDKSRQLVYELFMLNLNLPARVCIPMYANTIEHFVVRIPHTSGCVLNSKDKAPYCIYIEVVEVKSFYDSKIPVKLSEGSNFVTSSLPGLNIHPSSNSTLDSFTGNAVFQTQISQELENLSMDDGENDKLTQFDKLFVDDSYIESSSQISVDSEDNPKSSATAETSASTLNPAEIRQRLSELKKKKRKKMEHCPEDPSASAMSEPWEEKLIRIRESSPYGVLEGWKLLPVIVKTGDDLRQELLAYQLLTTLQKIWKEEKLPLYLRPYKILVYSSDSGMIEPILNACSLHQIKKNLVANPSYDDADQPYPPTLLSHFLITYAYSLACYFLQVKDRHNGNIMIDSDGHLIHIDFGYILSISPRNLGFETSPFKFTQELIDVIGGLNSDMFEEFKQLMLKGSQLPCFRGGPTLLKQLYERFHLSYTEPQLQELISGMVENSRDSLTTRLYDNFQYYTNGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQH8</accession>
    <name>A0A914YQH8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PI3K/PI4K catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2279.t1">
        <property type="protein sequence ID" value="PSU_v2.g2279.t1"/>
        <property type="gene ID" value="PSU_v2.g2279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF111">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE AGE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2279.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20766" checksum="06453CD991B25660" modified="2023-02-22" version="1">MECVDRFTYSLAGYCIATYVIGIKDRHQDNIMLAKDGRIFHIDFGHFLGHTKRKLGINRERTEFILTEHFLYIISRGKGNFRDTYEYTSFREACAQGFMVLFHNARFFIVLFRMMQCMGLPELSKQEHVDFIKHSLMFDKPKEEARSQFLKIFDDVVKSDLSTSVNWFFHSLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR93</accession>
    <name>A0A914YR93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YR93"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3285.t1">
        <property type="protein sequence ID" value="PSU_v2.g3285.t1"/>
        <property type="gene ID" value="PSU_v2.g3285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000358">
        <property type="entry name" value="Tau tubulin kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="54"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3285.t1"/>
        </source>
    </evidence>
    <sequence length="416" mass="47259" checksum="8A34F928CFBB2480" modified="2023-02-22" version="1">MSGAVAEGGGEEIPQKIEKKKEKKKKPLPTPVLHHHDEPGPVDLPLGKIVARRWKVVDKLGEGGCGAVYLVQNTKNLQKAALKAESNFVAGGSVLKLEVQILKKLIGRKYVAQLLTSGKKEKYGYMVMTVFGPSLSRIFKHCKREFSVSTQIRLGMQILYGLKQLHEVGYVHRDVKPANFAIGLKGKESRVIHLLDFGLAREFVIKNEAGFLELRRPRENTLFRGTVKYCSVNSHKRAEQGRPDDLWSMVYMLVEMRGPLPWDRSHDKHQIGKIKKDVTDEDLLLKCPPQMLEITAHLRELDYYIRPDYLRIYSIFEDMMNVNGIKYSDLYDWEIERRPKGYGTAGSTDKLKGGKLRRKISKILTVSEDVSMQKTSHVGEAQVSASINDKTSMQDESDEKQPPFSAEEFEKNELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRF9</accession>
    <name>A0A914YRF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Chloroplast protein-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRF9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2599.t1">
        <property type="protein sequence ID" value="PSU_v2.g2599.t1"/>
        <property type="gene ID" value="PSU_v2.g2599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000429">
        <property type="entry name" value="Preprotein translocase subunit SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1440.10:FF:000001">
        <property type="entry name" value="Preprotein translocase subunit SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3060.10">
        <property type="entry name" value="Helical scaffold and wing domains of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1440.10">
        <property type="entry name" value="SecA, preprotein cross-linking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612:SF0">
        <property type="entry name" value="CHLOROPLAST PROTEIN-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21090">
        <property type="entry name" value="P-loop_SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="Helical scaffold and wing domains of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="Pre-protein crosslinking domain of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SecA family profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="143"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2599.t1"/>
        </source>
    </evidence>
    <sequence length="417" mass="46528" checksum="B5D165F59B003EE5" modified="2023-02-22" version="1">MDEGESLYSPANIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLNAKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKLKPTGRYRHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYSQRNELLDVSDVSETINSIREDVFKATIDAYIPPQSLEENVGYSGAAGTSEERFRPRFANCRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRG8</accession>
    <name>A0A914YRG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g2772.t1">
        <property type="protein sequence ID" value="PSU_v2.g2772.t1"/>
        <property type="gene ID" value="PSU_v2.g2772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1888"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="130"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="237"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="554"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="657"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="864"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1236"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1345"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1559"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="1705"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1189"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2772.t1"/>
        </source>
    </evidence>
    <sequence length="2016" mass="223726" checksum="9EEB06C331BEC2DA" modified="2023-02-22" version="1">MNANTLITVILDDSVSIYELTPRFEQSFYRFEIEENQPPQLLGSVQAHHRATEIDNDQMVYTLHPNTDANEFFIDASTGELSSIKEFDRETQHLYKIQITGCLQSNSSSCDETEAVIVILDVNDNAPTFEEDPYKITISTDIDSQTELATVKASDVDLGKNGQVKYELLLNGNGNFKINEFTGELYYVGEAGDLKINRRFQLKIKASDNGVPSLSSETTVIINVGGENTNPNAPQFTNFRYEVTLPANVPADSSILTVEATDADPGPDGEITYKISDNDAARHDRIHQLFVIDPQSGEILTKQPLNANTDGPIIQFVVEAHDKSPTFPRKSETVVMLRFKERNAAKLEFVPLPKTVFISSEKPVGSEIIGISAKTVVENDFHKIRYGISVPNIADYFEVPANTGSLRVKKPLIEGRFPVTLTAYIPGTRLNATHSMMIVVMTDRDKYPVFDKLSYEMKVPISAAFPVKLEPLNATLSTGHIEYSLYQAERLPEGISVDKVTGQLTIFEEFVSAFDGAGNVFVVIRARNVDWPTFYSDAGVTLILSDTSTTLAFPAKLYRLVIPENKMQGTTLDPPIEVVNAQEIGNVEYFVEPVDSLFSINTRGELYLKKTVDLEELPLTSQGIVEINVVARHNGEKATTKVQIKVEDENEFTPVFLEDQYDFEIREQPKDGQALGTIRAIDEDFTDKGHLRYQIVDRSGAASTMTNILQNGTIIKKPGTRFENGIYEMIVEALDYVGHSTEIVVSFYVQIDGNARTPPPEPKEISEIWNIENNIIGSRFAVFGLPNRRWQFSIGEGNEDGIFELREINDTMAEVEIIAEPNITATNRKLEVEVIDIDDPQKTMMTNIEIDLSNAVSTKIPKFVDKTDNIQLPSNFNPNAVILTIKASQSEGNSKIRYEIVEDKNNIFEINPTSGEVTFAQNDKPKLPGKYELTIKATALDVPSGSAYSTEKVYAIEILPLSDNQSVSSTVPAEIVPEMTTTIHQEEGAPTAQEVDTIPTESETDTTLSFTPTEIDIVATEEEEVPTSIVVSSLPTELTPDETTFGETPTSAFTEEMTEPTPTHIIIPLFFEQPSYSFMVENQRRGSKVGEIQLSGAHLGSNLQMEITPPEMAEIFRVDSETNEIFLKKVPESSQESQEYLFNVTVFDGENPERRAQTEISVSMMPFIVNPSEAATSGETMFPTSTSQEEASLSSTVESVSAESEIPENEAPSAKPILTSTTGISTTDTLIDVRFVATQFTATLPEGRYSNAIISLKPAPLNKGMPPGVVYSIDFSTTMKNETFPFSIRETDGAINVFEEIDREFNEFYEFIVTGTLKEGDQEISDSVLVQITIEDVNDNAPEFINAPHVIALSTDISVGSVIANFTVQDKDEGAFGTVTLSLDGELKDYFAIDNNGILTLTKELSSSLGDKMNIVIVATDGGRPALKNVHMLTIELYSAETVQKPLFKESEYSATVSPNSSRGQFVEHVVAGIDKFNYAFENSYSDLFMVDNNGVITLGRNPLKNERNKQYLLNLTATDRNGEFSSAIVNIFLEGPTVAQIPTSAITPIKGDPTCEFKSKVYNTEIRENTLERRLLAKVEADCKFLPEDTSVLYIIHQGSKEFEMNEKTGELFVNAPLDRENRTLHFVVVNLTIVTPEQSDSNVRSSRQSGPIIDYARSKLSNNQALIVVKVLDENDNLPVFNRTNSKNEYVFPVDWQFPLKPIGRIQATDADEKSNITFTFAETSEYFSLHATSGIVTLVKSLEHADQEVYDMEVQAFDGKNTVSTRVKVYPLMPGVNIIVLTAKNPVEEINELAVSRELTQALEMDTRVLVKRIFVNEDNTFNREKSHLLIYALRKETHEPVPAAELKEKLEKLLPQLQSSSNLNIENISLPAVSSKLQMTNGEIMLLAAAGILFLATCIAFILCLRFCKRKTKLEKAEGEYMVDAESNGPRPYNVELISRRTAQSVLAGRELPNPFEEVKLSSQSRASLLTSSGMIFIDGQLDRSLPSIFSASQHETIDSRSTGSHQPQNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRV8</accession>
    <name>A0A914YRV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2389.t1">
        <property type="protein sequence ID" value="PSU_v2.g2389.t1"/>
        <property type="gene ID" value="PSU_v2.g2389"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2389.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39002" checksum="DBDC7A0FBE76CBBD" modified="2023-02-22" version="1">MMRIKEAIQRRKLIQQLNDEYDEFSHSFYNDIHPKKEGKESDLTSLDITPEDQRLNNLKVFVKDLNHRLTYPQRRALRVTWKRLSEAPKTSGRGNLQIMEKRCPGKSVTTLRDHAHLLIDFIDGILNVMFDQPLTKPVWDPLSIGKLHSKLMPLGFERQIWLKLGECFAEVMFSQECIRAYPHAASAWSLLAVSCTDKMYTSGRAQRSFEAPFPKLQHSLTSMSLSCPFTSQTPTTESSASSSSARSLQPSPSKSHSEDSSTTSTSSAPPNTIRLTAASSLASFFPNNAIPFELSSSSTQHPQQMPNSSSPEAVAAPRRKLPSDPICPVTNRRHLFRVKAESFSTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS11</accession>
    <name>A0A914YS11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2963.t1">
        <property type="protein sequence ID" value="PSU_v2.g2963.t1"/>
        <property type="gene ID" value="PSU_v2.g2963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2963.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14941" checksum="B3258E5FA2B1FA00" modified="2023-02-22" version="1">MSGIESVAGQKGLNFVRQWYESLNAKVLKPLLTKNYKKQLHDSSQILRAYQKITLQDAMNIFQSGQRPMSSMSNISDFNASIPAVCQLFNGLLNQKLHEKEHRSDSSEGDSYLSDNSIGITLTASSGGYRRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS80</accession>
    <name>A0A914YS80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3029.t1">
        <property type="protein sequence ID" value="PSU_v2.g3029.t1"/>
        <property type="gene ID" value="PSU_v2.g3029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3029.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26443" checksum="03A5883F6BD3D95C" modified="2023-02-22" version="1">MILEFLRSVVCCWHTCNPCQQQQMQPQQPVGCTTCGQNNYQYDQSSQGGYGGVNNGQYGQAQTQYSGNPYQQQQQQGYPQQQMQGGSGAQYQGSSNGYGNTNQYNPQQQSQYGYQNGQSSQYGSQQSQYGYQNGQNQQYQQMGTNSYAQGQQGQQGGATGASGSSNSSEPGYLPDYRGDKFTDPQRIKDTQALNAPFFQSIGGEPQYPGGVTSGNGSGSNTGTGGTNSNNNNNSYGQQYNGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS89</accession>
    <name>A0A914YS89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS89"/>
    <dbReference type="WBParaSite" id="PSU_v2.g252.t1">
        <property type="protein sequence ID" value="PSU_v2.g252.t1"/>
        <property type="gene ID" value="PSU_v2.g252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g252.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22176" checksum="AE90365D7E4220A2" modified="2023-02-22" version="1">MPSYSPDAPVEKVTITTDSAEFPRPISPPAQFEDFGPTIATSPPLPSLLKKMEQHDNDNPFRPQEPLYHEVDPIVEAYRNRPFPPSPVGSPIPHDHHHESRTTANSTNENGIHTTTTHEYHSHSHYASGNETPQKSNISSSKTHHLESTPKRNSNSGGAQHIPTISPDTQLLESNDLPPPKQPEIVHLEKKKRCGCCSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YST8</accession>
    <name>A0A914YST8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rho GTPase</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YST8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20494.t1">
        <property type="protein sequence ID" value="PSU_v2.g20494.t1"/>
        <property type="gene ID" value="PSU_v2.g20494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20494.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22714" checksum="C3D55E0BEDB1C950" modified="2023-02-22" version="1">MKKNLKIVVVGDGSCGKTSLIVAQAGGGFCDQYTPTAFDDYAIEALVNGKTKIVTVCDTAGEEDFNQLRPLSYPDADVFIVCYSVERPDSVKRIREKWIPEIRHFCPTAPIIIVGNKKDIREESNRKISHDSGLGNNENCLLPNVTISDAETLAKEFSSCPLIECSAKNRENIRLVFDTAIRAALTARNLCGSKVLQSIMKLKLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTG5</accession>
    <name>A0A914YTG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTG5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g345.t1">
        <property type="protein sequence ID" value="PSU_v2.g345.t1"/>
        <property type="gene ID" value="PSU_v2.g345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021010">
        <property type="entry name" value="Cytosolic_motility_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578:SF3">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578">
        <property type="entry name" value="PROTEIN CBG21223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12150">
        <property type="entry name" value="MFP2b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141739">
        <property type="entry name" value="MFPT repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g345.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33007" checksum="03DE81E1037ABE01" modified="2023-02-22" version="1">MDDKRGGGDGPPSGGPDPPSNNRNPPHSGGGAGSRAWNNGGVVECSFPYLEAELSGAKDLGGQIQILHYKGDHTNLGYWYERFEKSEERQPVKCGDSLPIFFKDRKGGSLVDFLDNKTEEARFSHDGVAENLTGTVLSDMWIIVRNFKDGPPFCECWKHGGSCPKPRPPLEVPPPPRVMVNELMDIRAGDPFPTHPLVKALNQFLNTIPGQNPDQYVALWYQQGEPVMGRVWNEGGKVAANFGWFNNEYKTNIGSIQVLVELPDQIHGFDYAWKTFKEAAVFGEKEWRYLSMCFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTW3</accession>
    <name>A0A914YTW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTW3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3102.t1">
        <property type="protein sequence ID" value="PSU_v2.g3102.t1"/>
        <property type="gene ID" value="PSU_v2.g3102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3102.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="25025" checksum="E6695919BBAE80E4" modified="2023-02-22" version="1">MKKRINRRKEFYQSRLQQSFPFRDTLINYIVKNPSSPKLYQKLIKTCKYFFAANPILVVKNFKLEIQDDDECNEIEIDAECWGEPNINTISTFLLKIFKCHAKKCVFDYLGDVSIKDFLFLTPKCKVISLCCFTVIDDDGSTVTLEKIVEVLPRIKAFYYYFYAVDASKIVSTGTVEKLLQVPHISKICKFFLDDVPESFDIERFFAYIKVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUB6</accession>
    <name>A0A914YUB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUB6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g423.t1">
        <property type="protein sequence ID" value="PSU_v2.g423.t1"/>
        <property type="gene ID" value="PSU_v2.g423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037986887" evidence="3">
        <location>
            <begin position="21"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g423.t1"/>
        </source>
    </evidence>
    <sequence length="481" mass="55817" checksum="C830DF73F1DD696B" modified="2023-02-22" version="1">MWQFFIFYLVVAINIKLCVAENDSTGNTTATTPYIPEVTLRPGSTLQLYCNGTHPAYCLTKISLDTENRTIARGLPQSYAAFKCPLLANLNVTNGITKWYLFNTSTLIGFYDYSNSFSKTSWTRNGSYKVLEDGGLLISEGRREYVNPYICTYENGSLFTSSAINTSIVLFRLNFSSWYSPIVFDSVFYGSVAVSVLLCGITFIINLIWIGIQKAGLYWIKRRERENRVQSMIEAVEVYRQRQIQNLQDAYHRNVSMVRDHYHMQVEQIRDAYTNQISRLKDYRQARMDNVTSHLDNIRDNYNQQLSRMREYGSRHGEQLFESYERQLNRVRTFSLQQRLKLMRQYKLKQRHVNKLLANVDESHLNVEGHSENLRKVFELSNEILPAESIPLRRSVSCLSLPEFTLVDGNDFPELKEIPGRRLTNNMDMRQWRRPQKKTVSECEEPVAGPSSSSRAPLKAENDVMKQAFEEQPLLNQKSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUH7</accession>
    <name>A0A914YUH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g332.t1">
        <property type="protein sequence ID" value="PSU_v2.g332.t1"/>
        <property type="gene ID" value="PSU_v2.g332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="936"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="547"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g332.t1"/>
        </source>
    </evidence>
    <sequence length="1298" mass="143983" checksum="C7819E14C5AE6574" modified="2023-02-22" version="1">MDLRRSPKPSTTTIAPPSPSPSPRPPSTTPSTSNIPIAAQALNRTKSVGSGDRPKRSQQVTIPGSDYGTMPRSPNRLAIPGADEQQQQQQPSTTSPKLSPNSNRPDRATIDSFNEEDVADLSPEQKFYYLRLMAKPGKRPEPIKMKFVRWAPPIDRKLSVDDEATLESQAMRVVRTIGQAFEVCHKVAQEQMQERPFEESSGSGGNNPSEGIRAKEERKLFFFFLFSVPFSQISASSAIGEEIDAQTLEEMVEERLATLQEVEVPESDSPGTQIPSAGMSSKRQSIMFPRKISSEVSSLGGGIMNEQQQQQLQQFNSQIPQQFMQHQHFPSISSTGIPFNNNNNQQQQQPQGQFHQKPSSSSIQSQQAPSTSGFNQQQGYFGGSFSSSTLPHSHTWNAGQQLQQQLQQQQQQQQQQFGGFSQAQSLEQVNQFNQMQQPQLSHQASQQSIQQQQQQPPPGTYPGYYPMMPGSVSVPYGLSSPVMVSPYATLQLPPHLQQQANQQQQQQGQEGGGISSDLAQTVPNIPAALQMSRNLDQYNQQMLRNQYDQQSQNMQVANCQVQLLRDQLTSETSARLEAQQRQTQLLSTNKELLEQVQALVNRLQNLETKISGEIHSIPGTSQQIPVTAGTNIFNANPPAPPSHATSVPLLSQATPIAPNDHHQMHYSFHEHVISPDVRLPGPAPINPQRPYQLQPLADIRAGSLPPEEQSELSSPKKRRRPADDSGTKTEPESATEDTTDYSSSDQYEKTGGIIRPMAAHPPENLIPHGVSYPEAFQGPHYNVLLSNPQAAQQYPHNPQMGSYFQASPPYAGMPPQQVMPRHPSSQHHHIGGTPLPMQHNPIINPLQGYPTHEHPGSGSSTHHRNKDDKEDGKFALIFKPQPGPSHQSESPEAGKKKVFKVGVLKEREFSRMSFNTRLNRDKKDKDKDKEQLETLIEQSIPEESGHSSGTPPLLQRYGNNNASPSPPLRRKITQMQFENQPLRMDPQSSPQKPTTTHVSQLNRGWMNQASQQQFQQQQQFPSVPASSSIATAMYPPVKTKPLNLNSKVQDTVKKQRARALSVDMEQIPLGNLSLHDPLIMPSRKNRQIPSTSFPTTSMAQQNAVSPQMPMPLNAPSRNMAAALERLNKTEMNYVSNNNPGDVLFYPPPTIQNRQNSPRRKMTEIGYDSRQRKSLQPSSSIELPGISPTTNYPSNNNNNNGNISHGITPLDPDSVKGRTLQAYEAQMLSDPSLLARLTRLPAHMQAQFPQPSSHHHHHPQQHHQHQQQNQELTGSGGSSSGGELDKSTVTVLHLPNGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV42</accession>
    <name>A0A914YV42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4468.t1">
        <property type="protein sequence ID" value="PSU_v2.g4468.t1"/>
        <property type="gene ID" value="PSU_v2.g4468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4468.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25600" checksum="926F0DFB17DF5CBB" modified="2023-02-22" version="1">MHALSQKNPINRRVIGSTRTSLRIAETDFLSDEQLRDKFQNDADGILQAYIHVSVAHNSVEDESRYRVPKLMIQDKSWPWRKRNNLGEKDCTFIVGTRSIAIHRFLLQMESTVYATMLQTKHYLESATGEFVIEDFTFPTVRAFVQFCYGEDISDYLNSTTRRMDLLRFADKYDMPNVMATLEEFSATKIRVTNVAQNLECATKYNAKLLKTACEEFLAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV50</accession>
    <name>A0A914YV50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21380.t1">
        <property type="protein sequence ID" value="PSU_v2.g21380.t1"/>
        <property type="gene ID" value="PSU_v2.g21380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21380.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13155" checksum="47BBB8F77146212B" modified="2023-02-22" version="1">MMMHRVSNKSNALKKNKKSQGNYTTDGIIFRQKSLLNKRGSECFSVGTCLIRLQDFSDNFNTFNYTVWTVANHNLIRKYEHVSSDGIHECFKPTDRVSTLFIYLINERHEFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWE3</accession>
    <name>A0A914YWE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2402.t1">
        <property type="protein sequence ID" value="PSU_v2.g2402.t1"/>
        <property type="gene ID" value="PSU_v2.g2402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037908649" evidence="3">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2402.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8148" checksum="114264D53BC91BE7" modified="2023-02-22" version="1">MRCAFIFLIALLFVSQALSAKTAGRVAHAGGPLCNPGTEFTCVDGYLCVLREYVCDGEQDCYDNSDELYCSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWW8</accession>
    <name>A0A914YWW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HTH psq-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWW8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4145.t1">
        <property type="protein sequence ID" value="PSU_v2.g4145.t1"/>
        <property type="gene ID" value="PSU_v2.g4145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545:SF13">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 93F, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545">
        <property type="entry name" value="TRANSCRIPTION FACTOR MLR1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH psq-type" evidence="7">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4145.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25524" checksum="4885D66115D547DE" modified="2023-02-22" version="1">MYSHLQQQQQHSRPQFDVETLQRMSEWQNQMFNMNMMQYFLRAPHLLPQFPSSSSSAALSQAQQQLFHLHNQQQQQQQNQAQLRPFILKDPPKKANKAIKSTKIQNSSENDEIPLDLSVKKSSKGIKGEEDDHGPTATSVDLNDKSCSPELNETGNKLTKRNYTQQALNEAVTEILSGRLGTRRASVVYGIPRSTLRNKIYKLESIDEANGEMKRKKAKKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZX0</accession>
    <name>A0A914YZX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZX0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5647.t1">
        <property type="protein sequence ID" value="PSU_v2.g5647.t1"/>
        <property type="gene ID" value="PSU_v2.g5647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5647.t1"/>
        </source>
    </evidence>
    <sequence length="618" mass="69378" checksum="97AB509D8CAF43A4" modified="2023-02-22" version="1">MFNGAFFRDEKKVICNKFTQSAPVTSLIWPEENRLIIGLTDGKVRYASVHSNKCSTIYKTDAGIVSLAQSPNHRSFVSGHEDSAIILFSFETRTQSKICVHTTPPYCLLLSNFGILAAGADKRIVSYSEQGRILQEFDCGRDPKERSFNCAILDPTGYNAIFGSFDRLKLMSWSQRRGAWDEGQILTIKNLYVVTALTWKPDGSTILCGNLSGLVLSIDCALKRALIKNQFETTFVSPSQVVVRDINSDARCIVRSEKGLSITDIRVMGRTSRYVIAYTASTLIMVDRETEKSSEIPWESGGNEKFYLDNENVGMIINAGEISFIEYGRNEIAGWIRTERLSPHLISARLNERSIRGGGDLRRVAYMLDVHTIAVVDLTSGNTISQINHGNVVDWLELNETGSKLLFRDVRSSLFLFDVETEKSSNMINFCSYVQWVPKSDVVVAQSGDQLCVWYNTDFADQVTQIPIQGDVDAVLRDNNRTEVIVQEANAKVAYELDSAMIEFGTAIEDLDLSRAVVFLEESEKDRVEVSSMWKQLAEVALEQGNLYIAQRAFAGLKDISRVKFLEETIQLAEEAAKQIGGDGTQHYKVRARLALMKKNFKEAERIYLEQNSVQELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z087</accession>
    <name>A0A914Z087_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z087"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5760.t1">
        <property type="protein sequence ID" value="PSU_v2.g5760.t1"/>
        <property type="gene ID" value="PSU_v2.g5760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="1">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5760.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16939" checksum="E8E3C03859ACC778" modified="2023-02-22" version="1">MGHRRHHVEHFRKGGFNTVINFVPQQEAWVIERMGRFYKILEPGVAFLFPCLDNIQYIHTLKEMTIEIPQQEAITLDNVQLDLDAVLYVRVVDPYKASYGVQDPEFAISQLAMTVMRAEVGKLMLDNVFRERANLNLAIVALHLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z159</accession>
    <name>A0A914Z159_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase FrsA</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z159"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5862.t1">
        <property type="protein sequence ID" value="PSU_v2.g5862.t1"/>
        <property type="gene ID" value="PSU_v2.g5862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000022">
        <property type="entry name" value="Esterase FrsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01063">
        <property type="entry name" value="FrsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043423">
        <property type="entry name" value="FrsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003460">
        <property type="entry name" value="PRK05077.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF4">
        <property type="entry name" value="ESTERASE FRSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5862.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47047" checksum="078D3F24966B8CD3" modified="2023-02-22" version="1">MTQANLSETLFKPRFKHPETSTLVRRFNHGAQPPVQSALDGKTHPHWYRMINRLMWIWRGIDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWATQAMVWQQKACAEEDPQLSGRHWLHAATLYNIAAYPHLKGDDLAEQAQALSNRAYEEAAQRLPGTMRQMEFTVPGGAPITGFLHMPKGDGPFPTVLMCGGLDAMQTDYYSLYERYFAPRGIAMLTIDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLESPRLKAVACLGPVVHTLLSDFKCQQQVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGYWKNDPFSPEEDSRLITSSSADGKLLEIPFNPVYRNFDKGLQEITDWIEKRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z212</accession>
    <name>A0A914Z212_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z212"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6742.t1">
        <property type="protein sequence ID" value="PSU_v2.g6742.t1"/>
        <property type="gene ID" value="PSU_v2.g6742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056492">
        <property type="entry name" value="SH3_Hsr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24680">
        <property type="entry name" value="SH3_Hsr9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="437"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6742.t1"/>
        </source>
    </evidence>
    <sequence length="528" mass="60242" checksum="AF441A65D77F1B07" modified="2023-02-22" version="1">MKNNRTKTAVMTESEESDDEFSILNCSTKKDRKNNSFKKATQKKSSKIKVKKEVDEGCKKVDRAAVPAVSNEHRTPKCQPLNSKALIEKRQIKRHQRNIFEGCEAEKKEEGEDPFNFDSKKDELPIFFESVNNNNKQRPCYNDIKSFINTPNITVKMGDEKQKLVSASSKKSSLSETPKISSNITETPAKLAKVETNNVQTSVKKPLPKIEEEIPVLNAEEQVVADDESNTFYPKGARVFAFYNKAYYPAIIDEFDGLGRYKIFFTEDNSKRTVPRDGIFPLHFVKEDMQVTVLGEYDEENRRIVYDGKIVAIPSLKNIEEWHRGLYKIEVTNNDHPEPESREIEWIDIFFDEVQYKRSKKNFTTNNQENNIGSRRRTRPSTALVASTATPKLPVTIPMPTSSSDIEKNGNDVKAEDTSREPKENSEVSSSSGGSKSPFKIFDKLQFILTSANRESGPRPFAKREVRKQIESRGGNVVETFESMNPDLTTYLIADTFYRTHKYLTALSLSVPTVSFKWINKCVEEVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z258</accession>
    <name>A0A914Z258_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z258"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6168.t1">
        <property type="protein sequence ID" value="PSU_v2.g6168.t1"/>
        <property type="gene ID" value="PSU_v2.g6168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF7">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6168.t1"/>
        </source>
    </evidence>
    <sequence length="477" mass="50652" checksum="AE2602326909DAE6" modified="2023-02-22" version="1">MGCPNSQVAFKDPITSAPKICTAAAQNCPVGYFCQFSTTNNQFQCCGMDGGCPNDQVSFIGISGEPQTCVMGQSTCPTGFSCQRTLTGSQICCTTGNSAETCTDGQVNVDGVCLKKMKLHEVCMNPAQCPENGDCDEGKCVCNKEFNEVNDKCLRECAIDEVRVKEECLKRVSVDKECIDSIQCQGGSSCEEGICKCPAAYHNIGGVCTKVSSRPDGKKGTAKKDDVCPMSGQVAFYEPRTKQIRICIPSKSNCPKGYTCQHSPTLSKNICCGRAATSPASKGTVKGTEAVGKSRPTSSRTTFAGKQDVCERGSAYLVNGVPQTCTSTTCPSGYKCQFSRKAKNYYCCSKTNSAAAHGCPSGTALLFPSTGTPVQCSNVGANSCPSGYACVKNTKNGNYQCCTTGTAASALHKLSSRKDDVRNNASGCPSYQVQVQRVVNGRVVKRCENSCPPHQVAVRGICRDVHQSDDPIPINDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z284</accession>
    <name>A0A914Z284_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z284"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6007.t1">
        <property type="protein sequence ID" value="PSU_v2.g6007.t1"/>
        <property type="gene ID" value="PSU_v2.g6007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6007.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18017" checksum="576BAB2F5CCA6DA9" modified="2023-02-22" version="1">MQLPQQTSSQQPPQQPPQQQTQQLSQTSHIHSSKQQPSQQQISVQSQPPSAPSTTSTTPVGNGSEQVFYYSPYSAHDSSPQSLPEDQLDSQQPGEYEYWEDKMEYSDSSLNGTIMTDYDIEEEHCIQRTTRPSGQITVVQPIQHQIVDSHNHKYFKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2T5</accession>
    <name>A0A914Z2T5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2T5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7021.t1">
        <property type="protein sequence ID" value="PSU_v2.g7021.t1"/>
        <property type="gene ID" value="PSU_v2.g7021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7021.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12832" checksum="719F6E33771D7F2E" modified="2023-02-22" version="1">MTRINALISIDFNHIVKKRFPNWSAKSLAREWEEIWSKKILHYALNNGNSFAVNALKDYGLEKIPSISEEDRCIFSLRLLPSLMQGKGTKVTGSDADSLITEIKVSLFCVFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2X9</accession>
    <name>A0A914Z2X9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2X9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7059.t1">
        <property type="protein sequence ID" value="PSU_v2.g7059.t1"/>
        <property type="gene ID" value="PSU_v2.g7059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7059.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7994" checksum="C183D2437230EAE4" modified="2023-02-22" version="1">MEKCQYEYGGRLATAPSNDAFKFWTRTIHFNTKIDFNNLFWIGYGKNGFNNQEPDVKLKKFIDPQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3X9</accession>
    <name>A0A914Z3X9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 14">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 14"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z3X9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g706.t1">
        <property type="protein sequence ID" value="PSU_v2.g706.t1"/>
        <property type="gene ID" value="PSU_v2.g706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000003">
        <property type="entry name" value="Signal peptidase complex catalytic subunit SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="15">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g706.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20474" checksum="DECB1E373F0ABF68" modified="2023-02-22" version="1">MAIFDYPIFDEIRRMNKRQVAYQVLNFAMIVSSALMIWKGLMVVTGSESPIVVVLSGSMEPAFHRGDLLLLTHNREDPIRVGDITVFKIEGRDIPIVHRVIKVHETASGEIKFLTKGDHNQVDDRGLYAPGQYWLTDKDVVGRGTGFVPYVGMVTILMNDYPKLKYTVLGLLGLFVLIHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4Y6</accession>
    <name>A0A914Z4Y6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z4Y6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7416.t1">
        <property type="protein sequence ID" value="PSU_v2.g7416.t1"/>
        <property type="gene ID" value="PSU_v2.g7416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF3">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="2"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7416.t1"/>
        </source>
    </evidence>
    <sequence length="524" mass="58992" checksum="D5A1920B7B30B759" modified="2023-02-22" version="1">MNELRFQKPVPPDPWNDVKDCTQFGARCPHDEMWIERFPSVALKHEDCLRLNVFSPEWEPSKTGQPDGFAVLVWIHGGGFAVHSAAHYGDYGICEALCLKDVIVVTIQYRLGFFGFSCGEGIPSNLGLWDQTLALKWVKENISAFGGNPNNITVFGQSAGGASSDLLSISPHSRDLFQKVVPMGGSGCCSFAFNDKEHVSNICLDYATKLGYKLPEKVKADGDVVLYKTPFEFLRTLPANKLQIGIIGKRDAKVNQNGKLDLTPVYDGDFFPKPIDELRKEAPKKLIMTGITEHEGLLFIGLKPPRTNIHDEIPKLLERELLHQGIKDIEYAKETMMKMYLHGHNIDNKKDAIKIAVKIVSDVFINNGVWKYADTMTKLGHTVYQYCFEYCNPNNFGLLGYVLPFKAATHGTELPYIFKKGVISYFNPNEDDLKVVEIMTTYFTNFAKYGNPNGVGNVPQIWKPLTPEDTLKYMCINLDKVRMCDNLNDGRSKQWETLYEKDSGNAISYIADDQIKKQDISGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5U0</accession>
    <name>A0A914Z5U0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5U0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8052.t1">
        <property type="protein sequence ID" value="PSU_v2.g8052.t1"/>
        <property type="gene ID" value="PSU_v2.g8052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF20">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8052.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15434" checksum="F6666C144AD1E86E" modified="2023-02-22" version="1">MCAIWPGNVLWSCKDNSQLLSIIDWQGCFVGSPTADLAALLAISVDAEERQKNEDEYLKYYIQKFDELQDNEKVVFSALDFGTVKEAYGRSLLYSMIELIVVIISNPMDDVIEEEGEIYGVMTKRLKALIEDLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5U8</accession>
    <name>A0A914Z5U8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5U8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7321.t1">
        <property type="protein sequence ID" value="PSU_v2.g7321.t1"/>
        <property type="gene ID" value="PSU_v2.g7321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16662">
        <property type="entry name" value="RING-Ubox2_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7321.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19354" checksum="8DA2B8C482851BBC" modified="2023-02-22" version="1">MIESVERVIDIPAYDADGLPVAGSAYKSVSNMTPVEAKKHRSFWDPAISASLKEGTITKPDKTIRNPYTQKPLKYKDLLPVVFTAIDETLSHAQRYMCPVTRDVLTNSTKCCYLKTSSRVVNAACIEMILKDGSDPINGKPLTKDDVISMHRGGTGYARTNMLKANLYRPQMALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5V2</accession>
    <name>A0A914Z5V2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5V2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8061.t1">
        <property type="protein sequence ID" value="PSU_v2.g8061.t1"/>
        <property type="gene ID" value="PSU_v2.g8061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021730">
        <property type="entry name" value="YdbH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11739">
        <property type="entry name" value="YdbH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8061.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11048" checksum="3A512EA21AEB4D02" modified="2023-02-22" version="1">MDNSQLPLQLTGEAKQADLILYARLPAQLSGSLTDPTLAFEPGALLRSKGRVIDSLDIDEIRWPLAGVKVTQRGVDGRLQAILQAHENELGDFVLHMDGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z608</accession>
    <name>A0A914Z608_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Splicing factor 45</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z608"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5675.t1">
        <property type="protein sequence ID" value="PSU_v2.g5675.t1"/>
        <property type="gene ID" value="PSU_v2.g5675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5675.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17659" checksum="04D55541562A9FF2" modified="2023-02-22" version="1">MGYTFGSGLGKHGQGMSSALKIEKKGGQAGKIIHETDEVMREVGLNPETFQGPITNILLLRNIYTLDDIPEDYDNELRPELSRYGVIKKLILHRDPDAEDFFDQVRIFVDYPNKAAAIRAYADLNNRFFNARSIRATFYPTDRFMLGHYYDPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z743</accession>
    <name>A0A914Z743_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z743"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7713.t1">
        <property type="protein sequence ID" value="PSU_v2.g7713.t1"/>
        <property type="gene ID" value="PSU_v2.g7713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037892530" evidence="2">
        <location>
            <begin position="26"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7713.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="27953" checksum="EBC42B0AA96A5807" modified="2023-02-22" version="1">MNCCCFKTFFVFLCFQLGFLDSILAAKLQRHENVSNDSFILNSNDAINEQLPSDNLLADGSVRAIADGNDIRLSGYGSINLTLTLETLQFEVCDICEGSSKVCFDTAKVHSKAACSEYSSYCKFEVKYEKDEQTRAERIYFNDIWVSKNDFVPRCLRPTMHWGEVVAVETSKFMSCDPKIDGVDKIIKLYVGIEPSCPIKVINAKIYVPEVSTKNSSSNSTSADESSAASAPVWAIVIMVLGGIAVIIIIGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z851</accession>
    <name>A0A914Z851_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PB1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z851"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8043.t1">
        <property type="protein sequence ID" value="PSU_v2.g8043.t1"/>
        <property type="gene ID" value="PSU_v2.g8043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048208">
        <property type="term" value="P:COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033512">
        <property type="entry name" value="TFG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15335">
        <property type="entry name" value="PROTEIN TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15335:SF7">
        <property type="entry name" value="PROTEIN TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8043.t1"/>
        </source>
    </evidence>
    <sequence length="439" mass="48691" checksum="E3528A78A6139909" modified="2023-02-22" version="1">MSGQITLKVKYGADIRKAVLPSAEINSFGAITNWIAETYNLNDSNNLLLKYMDGEGDLVTFTNDEDLHLALSTESLFYVHVFSNSEDTNAIVSQLLKEFDHLKHKMDNVKIMIEDNASYLSQGRYSRPSTPPNHKSESIATIQPSVHEEIDHNGVARIVSSEIKEQPRDDMSSSHHDENQHMENIPIDQHSSHSPHPNHDHQQQHPPQFPPSQGGNNNNMQQQQLGGGPPPQQQNSGFAPPPPHGFPPMSFPTQNQQQPPPPQQQQQKFRPPSEQGMGMPPPHMQPPPTSQGGFGSMPPPMNGAPQHHQQQPQHPPNNFPPPQSGTPQHFAPPPMNGPPQHQQQHQQQSPNVPPQSGTPQHFAPPPQSQPSPFQPQHQQHGHETPSHMPPPQGMNGMQQPPTFYQPQSAPPQKYGPPPTLPGLGNPFARQQFQQGPPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9F7</accession>
    <name>A0A914Z9F7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z9F7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8442.t1">
        <property type="protein sequence ID" value="PSU_v2.g8442.t1"/>
        <property type="gene ID" value="PSU_v2.g8442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000001">
        <property type="entry name" value="Sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8442.t1"/>
        </source>
    </evidence>
    <sequence length="550" mass="61232" checksum="3259491F33693D1F" modified="2023-02-22" version="1">MPFDKATAIAHTQFFIDEINDRLSRFSPIVLVGGTAVSIYAYFRIRTILRRSDRPVHQRLMGYFVSLARYLPSVENKIQKQFEGIRGEIVESIHKYDQDRIFIRELLNTQLSPEDVIQKASEYESMGTFDVNGGRVSGTVYTDRDQKHIDFLSEIFKKYAYSNPLHPDVFPGVRKMEAEVVRMAANLFHGPPEACGTVSSGGTESIMLACFAYRNRAYAKGITEPVMIIPVTAHAAFDKAAFMMNIRVKHIPVDCNNRVNLKAMRSAISSDTCMIVGSAPNFPTGTIDDIAQISNLGLRYKVPVHVDACLGGFLIPFMEEAGFPLSLFDFRLPGVTSISCDTHKYGYAPKGTSVILYRSPEYLHDQYFAVTDWTGGIYATPTLAGSRSGLAIALTWGTMMYFGRNVYVSRTRAIVDSARELAKQIATIPGLEIYGTPEVSVVAFRSKEFNIYAVADKMNHLGWNLNTLQHPDSIHFCMTFNQARGEVITAFIADLRKACEEVNEMPNKGGASKTAAIYGTAALIPDRSLVSSMTHVFLDACYSMPEKLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9S6</accession>
    <name>A0A914Z9S6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine--tRNA ligase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mitochondrial methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9S6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8667.t1">
        <property type="protein sequence ID" value="PSU_v2.g8667.t1"/>
        <property type="gene ID" value="PSU_v2.g8667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8667.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23086" checksum="AE3F319924C452D5" modified="2023-02-22" version="1">MIQVYITIPKAIDLVNSELVNALGNLLSRCTVHKLNPNQVYPTFYDEILKSSLKEDGQRIVDGLNSLAENVTKCFDELYFYRGLEFIFEQIRNTNALLEIHRPWNMTEGPELSTILFISYETIRISNILLQPLVPEYSNKALSRLGLSDKERSLNTAKFGGGKWLNLDGKKLGENYGNVMTRIAVKDANPVTKKKKSLKKSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAM3</accession>
    <name>A0A914ZAM3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZAM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7301.t1">
        <property type="protein sequence ID" value="PSU_v2.g7301.t1"/>
        <property type="gene ID" value="PSU_v2.g7301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="72"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7301.t1"/>
        </source>
    </evidence>
    <sequence length="274" mass="32399" checksum="77B8253F8C7304CB" modified="2023-02-22" version="1">MKLPSGEYEPIFRIYEDDPKTPLQIRVKQHYYNQHKFQTLDFVKNMHKKWLSFNHAKLPLLECLDLLSQLVDESDPDVEKDANIIHAYQTAERMREAYPDRPWLHLTGLIHDLGKVMSVWGEVQYAVTGDTYPLGCKPAESIVYGIQSFEGNPDLNDTVYQTKFGIYKKNCGLEKLVMTWSHDEYMYQVLKNHSTCKIPEEALYAIRFHSFYPYHSSREYLYFESEYDKNMLKNIFELNACDLYSKADERPDLQTIRPYYQSLVDEYVPGVINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAV8</accession>
    <name>A0A914ZAV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8899.t1">
        <property type="protein sequence ID" value="PSU_v2.g8899.t1"/>
        <property type="gene ID" value="PSU_v2.g8899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8899.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13302" checksum="EC4683F56FD01727" modified="2023-02-22" version="1">MLKSNISEQAIHGVRINGIGPLTVEAASTDPNLDITPLNIHQYPQNPGIWASTTCPDDNSPPEMAQMPPPPYMMMNHGNYNNEMPSSGNYGYPSNSATGGYMPSGGGGGGGHGISADYSSLSSPSCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB12</accession>
    <name>A0A914ZB12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9103.t1">
        <property type="protein sequence ID" value="PSU_v2.g9103.t1"/>
        <property type="gene ID" value="PSU_v2.g9103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="36"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9103.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21200" checksum="315D561428113199" modified="2023-02-22" version="1">MRSEAVQNERDRISITTKKLCDGTDPASSSPGPSVESEPCINKLMHAESTMRQLRASVITRTADAYRTATTVDVTESMHQQLILMVEWAKQIEQFRRLPMQSQIGLLRHFSAQHLVICAAYRSIGAKDDSIYLNNYSCLPRDAPKIPDVNRVAARILDHLTNPMKRLHIDEKEYVALKAVAFFDPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB27</accession>
    <name>A0A914ZB27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-D-phosphohexomutase alpha/beta/alpha domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB27"/>
    <dbReference type="WBParaSite" id="PSU_v2.g952.t1">
        <property type="protein sequence ID" value="PSU_v2.g952.t1"/>
        <property type="gene ID" value="PSU_v2.g952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000001">
        <property type="entry name" value="Phosphoglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050060">
        <property type="entry name" value="Phosphoglucosamine_mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42946:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE (ALPHA-D-GLUCOSE-1,6-BISPHOSPHATE-DEPENDENT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42946">
        <property type="entry name" value="PHOSPHOHEXOSE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g952.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17046" checksum="E2EC28551167589A" modified="2023-02-22" version="1">MTPDITMRVGMAVGLSFRDGGQGQRVVIGKDTRRSGYMLENALVAGFTSMGMEVFLLGPIPTPAVAMLCRSLRADIGVMISASHNPYYDNGIKLFGPDGYKLSDALELQIEKLIDDDMSVHMSSHGEIGRAKRVDGDIYRYIEFAKRTMPRHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBF7</accession>
    <name>A0A914ZBF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9257.t1">
        <property type="protein sequence ID" value="PSU_v2.g9257.t1"/>
        <property type="gene ID" value="PSU_v2.g9257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="232"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9257.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47451" checksum="A3F783E2D7330C76" modified="2023-02-22" version="1">MASTLGTIKTAINELVFNNKEHETAVPAQPQWSDTKTMKCLVWNGKLQVDYVDHAQPIITAPTDALIKVSATTICGSDLHLYKGTFAGMQKGDILGHEFMGYVEEIGSEVKNIKVGQRVVSAFGIACGVCNFCQKEEYTSCDKTNPSKTQDNMYGDRLSAIHGYSHLLGGVPGGDAEYCRVSFADVNLFPIPDEVPDEKALYLTDVIPTALHGAKMGEVSRGKTVAIWGLGPIGLMCAQWCKILGASKVIGIDEVPERLAVAKDILKIETINFKDEDVFKAIRERLELPSGVDVAIECAGFDYAQSWAHKIEMKLGLETDTSEIFQEIFRCVSKGGNVSIIGVYTGYANHFPVGAMMEKNITIRGGQCPAQKYWKYCLEKIQSGELDTDWLITHRGSLADGPKFFEKMNNREDGCIKVFMRPEFTVGKSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCR1</accession>
    <name>A0A914ZCR1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZCR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9726.t1">
        <property type="protein sequence ID" value="PSU_v2.g9726.t1"/>
        <property type="gene ID" value="PSU_v2.g9726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9726.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45197" checksum="56CF7E0D7116D39D" modified="2023-02-22" version="1">MVYKFTAQPLVKTIFQKGFATCFAYGQTGSGKTHTMGGDFEGKTQDCSKGVYALTAIDVFKTLQQPEYQRLKLQVKCSFFEIYGGKVFDLLGRRAVLRILEDGNKSVQVVGLNEVSVSSPDDVMKLIKQGSLQRTAGTTSANANSSRSHAVFQIILKSQKEDIHGKISLIDLAGNERGADTISSDRQIRLEGAEINKSLLALKECIRSMSMNKSHIPFRLSKLTLVLRDSFVNQNAKTCMIAMVSPGLNSVENTLNTLRYADRVKELGSGDEMLKPMADEEFMIDPLDEEENDIPIPLIEQNGHSDDENTKAIHQSAFHVQQAEERAVDSNMILQAYVADNQELFNRPGEMGYDIEQYAKDSLTFLNQLEKLCQNAKAKTQDLLIKCQKEEELSSSRQYPKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU21</accession>
    <name>A0A914XU21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XU21"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10030.t1">
        <property type="protein sequence ID" value="PSU_v2.g10030.t1"/>
        <property type="gene ID" value="PSU_v2.g10030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF84">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10030.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31275" checksum="F5DE3B8C6C41D6FD" modified="2023-02-22" version="1">MEFQIIRSLIDNRRNPALARAKIFQKIFQGLFVGGVYWRIKYIDFVDVQNANGALFYLLAELTYSALFGVLTFMPNDFPLVVREHFDGLYYVPAYYIARILSYMPIFILDGTLMMAISYYMVNFAPGFGNFVINIGIGILIEQAATSFGVMLSTVCPSYAIALSITGPILTVFSLTGGLYANVKKMKPWIQWIQWCSWFRYGFEALTINHWHGMPKNITHNDTIGSIGKTATQILDEYSFVQSNLGMDLGAMIAFTLLFYFLGYIGLHIRVRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUG8</accession>
    <name>A0A914XUG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUG8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10176.t1">
        <property type="protein sequence ID" value="PSU_v2.g10176.t1"/>
        <property type="gene ID" value="PSU_v2.g10176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10176.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28781" checksum="A97A594922F6E691" modified="2023-02-22" version="1">MLYFPDTVKFCASLTTNKNVLTLSKDRQRTTFLQPLLSIGIKEIGVQHRCQINFMGYGGEYRLSPDLGYYTHCQRSISQYINQLVDGEPKPEWNASNPQCPIQELPNSYKDYLACDLVPLKWYELDFESSMRYEVFHKKTYQQFTSNYSTTFLFKPDYFLERNGSEADWLTRLIEIKAKLKGCKKVRYFIRIDDQWKLPITVHIEYRITHDGLIKYSHHVGSGTIEHWFSGSFPFIRSPSRDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUR7</accession>
    <name>A0A914XUR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUR7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11684.t1">
        <property type="protein sequence ID" value="PSU_v2.g11684.t1"/>
        <property type="gene ID" value="PSU_v2.g11684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11684.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16225" checksum="1C81C97D05C51D7E" modified="2023-02-22" version="1">MGGGGGRDDLWPDPKKQSDFLRIIVATASTNQSDLRNLTYDFISKVLGSKLIETIVERCIGPLMYDTNMQEEPIYAEIAHYIVKLLLLGFISLPSKMDSHLLRVQNVTTSLKEVRDICLKEETKIQLERLEIALKVTIDVLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUW3</accession>
    <name>A0A914XUW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUW3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11034.t1">
        <property type="protein sequence ID" value="PSU_v2.g11034.t1"/>
        <property type="gene ID" value="PSU_v2.g11034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11034.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17266" checksum="D6C75AF2E9596BA5" modified="2023-02-22" version="1">MLIPCCCFCFNSHSPSERERMSPPQNQQSNQQQQQSSERNTQSNPSATGAGGRKRTTTPTSKTTSESETEKISAKEYKERGNKLYQAQRYEDAITNYTAAIMRDNTSPTYFTNRALCFLQTKKFDKAEQDCRRALELDQKNIKASLFLLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXJ3</accession>
    <name>A0A914XXJ3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXJ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1267.t1">
        <property type="protein sequence ID" value="PSU_v2.g1267.t1"/>
        <property type="gene ID" value="PSU_v2.g1267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000030">
        <property type="entry name" value="tubulin beta chain isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="112"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1267.t1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34451" checksum="A3EE7A10E60EED7E" modified="2023-02-22" version="1">MTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDSTFCIDNEALYDICFRTLKLSTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRSNQLYRANTVAELTQQIFDSKNMMAACDPRHGRYLTAAAIFRGRMSMKEVDEQMLNIQNKNSSYFVDWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQEIFKRISVQFTAMFRRKAFLHWYTGEGMDELEFSEAESNMNDLVSEYQQYQEAAADEDAGEAFETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXU4</accession>
    <name>A0A914XXU4_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXU4"/>
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        <property type="protein sequence ID" value="PSU_v2.g12022.t1"/>
        <property type="gene ID" value="PSU_v2.g12022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12022.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="22267" checksum="C521524DA9EFD2E6" modified="2023-02-22" version="1">MSSSDERQQRKRKRTVTPEDYQKERCRTPEYRHDEYRKERRRSPDYYRDDNRERHKSPEKYRNDNCERRGRISQMYERDYGRSENDRTRYEKDYDRKDYGRCSRSDDRYGRGYDRREKHYDRYEKDYGQYDRDYDRYERDSSRGSSLVSTKRRRRNSDETPRRSRRGKLSFDSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXY3</accession>
    <name>A0A914XXY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXY3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10586.t1">
        <property type="protein sequence ID" value="PSU_v2.g10586.t1"/>
        <property type="gene ID" value="PSU_v2.g10586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10586.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="17060" checksum="1A1339F36B8FA86B" modified="2023-02-22" version="1">MEEDTVLVSDRNNAENDFKCYAKIMSEPLQRSKLINHSNEKTAEKSENERKWDSFAQKVNPIDEEIAKEKYQELTQSILNESIQKQQEEETEYEEVIEINRLYESYDFDFEEEEEYLPKLKYEPQTITSEDINSEFDIKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZI9</accession>
    <name>A0A914XZI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12625.t1">
        <property type="protein sequence ID" value="PSU_v2.g12625.t1"/>
        <property type="gene ID" value="PSU_v2.g12625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="106"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12625.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25752" checksum="07DF623EB39EF2AB" modified="2023-02-22" version="1">MNRFITARTFTIAKRCDHLLFSQRHLIVPSQKSFNKSVDEYVENQLQKEPSKIPIRLQTAYAAIRKKFKREPDNIDPELRNLLDKAAGQLYYDCANKYPYLALCKSFGLEDYMSTWFKLTLIHVWMILLRIHVTLDAAAYNRIRDGILNTLWLDVDKRLELLGAQLNQKLNTTADMRKMNGLYIQTLLEFDEGFLQDDTFLAAAVWRNLYLQRSFDPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZJ6</accession>
    <name>A0A914XZJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZJ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11075.t1">
        <property type="protein sequence ID" value="PSU_v2.g11075.t1"/>
        <property type="gene ID" value="PSU_v2.g11075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11075.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23427" checksum="897CF4765567BCC5" modified="2023-02-22" version="1">MICFKRISFRKKDSELQKCESALEAFRESVKTKDEVIMKMWENQESLEKLTRERAVTVTEAIDIGIPEGIPVDGGTSTEEATRFLLDEFSVDDVDQLKDLVVGYQSQNHFLNDEVLQLQKIVETLEERERKIIRQNFEIEACFYQLKSRYMMVLNHFRSGFEEAKKKLGPEIIEELLEDVSRPLKFQHREDSVSPRRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0V7</accession>
    <name>A0A914Y0V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0V7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13085.t1">
        <property type="protein sequence ID" value="PSU_v2.g13085.t1"/>
        <property type="gene ID" value="PSU_v2.g13085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF235">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING RGS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="148"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="276"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13085.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44862" checksum="53819F5CB87290D3" modified="2023-02-22" version="1">MSMCFPLLRSRPLSKKTVVPAEPPPPPDPEPEHQEAAVTAPESEQHSRPSTSKEDTPLPTVVESPVTVESSPPNSTSSTGGRLSVDERRIIKTPPPPSSKALSRPPLGLPPDMDLIFDKEHSGNKAELELPSTDGLDYPRAASWSSCNVNEIMHDALGKQVFRCFLAQALAEENMTFWEKCEEFKKCKDNDALQAAVADTMESMGTYVNVSAPARAKLMEVAKGTKVDKKMIEPASKEIYKLLENDQLPRFRRSELYLGFLEKLLPRSYAEKWKLNFEALLGNQVGRHYFRRFLISIHAEENLKFWEAAIEFKHSKNKSAAMARSIYDQFLKEGIPNEVFLPHGVRNNLLRLIKEKEIDGTLFDDSIKYVEQVLRNDPYVRFLQSDTYKDLLSRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y170</accession>
    <name>A0A914Y170_9BILA</name>
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        <submittedName>
            <fullName evidence="3">CHK kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g12531.t1"/>
        <property type="gene ID" value="PSU_v2.g12531"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12531.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24854" checksum="1782A70A72338772" modified="2023-02-22" version="1">MRGNFIKGDDEAVDGFLINCKRNELFELVEKYRNFSINENFIHFINVQAHKDLTLASVIVHGDITSNNIMWETDSEGNVQNTIAAIIDWQVMHEGSPMSDLASFISLCCDGVVRRQAEEFAIQYYFECLAKEFGDITLIPYTVEKLQTAYDYFFISFGLHTLGSSGFIFQSVNESNEALKEAYYNFGILKSLNAWEDVDRLLQGKYKHIFQKYQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y171</accession>
    <name>A0A914Y171_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y171"/>
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        <property type="protein sequence ID" value="PSU_v2.g13951.t1"/>
        <property type="gene ID" value="PSU_v2.g13951"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13951.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="23361" checksum="503648F91C3A2942" modified="2023-02-22" version="1">MNILLSPLMRINYIGNIFDADIKVPKLLAFIRYNVMVCRDLPHYSDQNEDQNLLTKLKYLMKVSFPSEDINFESKTEQERAIKKWESAKFHENNFNLPPGSRWIGDINALALELFSTLCYEIEKNPAKKFEAFDKLYSKIFLERNEDLAEVYFKTWHRHLEQYHQEKTLFMENLESYIRSFPKNDVLTMLYISILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1Q8</accession>
    <name>A0A914Y1Q8_9BILA</name>
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        <recommendedName>
            <fullName evidence="2">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1Q8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11756.t1">
        <property type="protein sequence ID" value="PSU_v2.g11756.t1"/>
        <property type="gene ID" value="PSU_v2.g11756"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
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        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11756.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12893" checksum="88B3A156E7019553" modified="2023-02-22" version="1">MKRPGYRYRKGTCIVEKPRIDPFKHIEEKLTVHKAVPTDPATDAQIILLHQLYTELKEITHRIFEEDEKECIENDWQFAAMVVDRACLITFSVFITACTLAFIFCAPHIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1T5</accession>
    <name>A0A914Y1T5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase family 31 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1T5"/>
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        <property type="protein sequence ID" value="PSU_v2.g14143.t1"/>
        <property type="gene ID" value="PSU_v2.g14143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000046">
        <property type="entry name" value="Glucosidase alpha, neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000039">
        <property type="entry name" value="Glucosidase, alpha neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000023">
        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF145">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="6">
        <location>
            <begin position="95"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="362"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="697"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="7">
        <location>
            <begin position="802"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14143.t1"/>
        </source>
    </evidence>
    <sequence length="925" mass="106264" checksum="F70A5187FA0A765A" modified="2023-02-22" version="1">MSYILNHGDRWKARIGEKKKVSMRAVISLFILLLAINLCIAVDRSKFKTCEQAAFCKRHRIQEKTADYSVDPTSVKANETGLQATLTSEVNNLKVELVLLKDNVVRILLDEAGTPLRPRFQPLIALNGTPVHEHVIAAEANPESASFVTPTGFKIIMNFKPFRIDVFNSKKELVISVNSKNLLKFEHFREKGADAGEDGFWEENFGGHRDSKPFGSSSVGLDVSFIGFKFLYGLPEHADTFALKSTTNSEPYRLYNLDVFEYELNNGMSLYGAVPYVIANNPTQTVGAFWLNAAETWVDIASSTADKGVLASIVDKFKASKDVPQMDAHFISESGLAELYLILGPKPYDIFRQYASLTGVYPLPPLFSVAYHQCRWNYNDEDDVAMVNAGFDQHDIPMDALWLDIEHTDGKKYFTWDPVKFANPQKMIDGLSSKGRKLITISDPHIKKDDNYPVYKEAKDQGYYVKNVEGNDFEGHCWPGASLYLDYMNPEVRNYWASRYHFDKYIGTDKNLHVWNDMNEPSVFSGPEVTMNKDARHFGDWEHRDIHNIYGFLQTISTHKGLIERADKKVRPFILTRSFFAGSQRVAAVWTGDNTADWDHLRISIPMMLSLSVAGIPHVGADVGGFFKNVDEQLLVRWYQMGAFSPFFRAHAHIDCKRREPWLFSDPAMNAIRNAIRTRYSFLPYWYTLFYEHSKTGLPIIRPLWSEFPEDEQCYDEEREFLIGNGLLVRPIAEPDVTQVSLYLPGRRQVWYEWNNDKTRPSPGAVYVDATLETIPIFQRGGTIIPTRQRPRRSSALMKNDPLTLYVAADTKDFANGTIYLDDGETYDYENGQYLYWGFTYKKESDFVYTITSKNLDPKGEFDPDVYIEKIVVRGVRYYPRNVHLYYDDYNPEGLEFEHIRDKHLIVIRKPGAYVSREWRIDIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2C9</accession>
    <name>A0A914Y2C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Insulin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2C9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12937.t1">
        <property type="protein sequence ID" value="PSU_v2.g12937.t1"/>
        <property type="gene ID" value="PSU_v2.g12937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003235">
        <property type="entry name" value="Nem_insulin-like_b-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03488">
        <property type="entry name" value="Ins_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038023017" evidence="6">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12937.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13494" checksum="45CFDE6CD9D6923E" modified="2023-02-22" version="1">MKALIFAALFFTAFILIVVNGYETKNDLVLNTWMNEMNKPVEKSNDHIRPKRKIAGHWCGKLLHIKIADALQSCGRTLPLKFKRSLNDDKNNYNSDNIVVKCCQKGCTMDELKHFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y438</accession>
    <name>A0A914Y438_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y438"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13542.t1">
        <property type="protein sequence ID" value="PSU_v2.g13542.t1"/>
        <property type="gene ID" value="PSU_v2.g13542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13542.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22132" checksum="316F2D2C0802ABBB" modified="2023-02-22" version="1">MADARLSETYECAEDSCKLSVGLMIPSSSFADVAASTVMDLAEKVHIAGSAKWKAEAKENVLRKGGNDLDEEIVTAPKAVLHAAWRVALARCPHRRDAFIASIGKSELTQNSGDLEMVHNMMAFVANAKFMGSSGKTDVVVAGGQNASIFARAINAQHWPMMVPDECLLRSKVIFGAAVKKVIYIPNGELFFRFTRIIGNVIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y450</accession>
    <name>A0A914Y450_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor-like beta-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y450"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14977.t1">
        <property type="protein sequence ID" value="PSU_v2.g14977.t1"/>
        <property type="gene ID" value="PSU_v2.g14977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="entry name" value="TonB-dependent receptor, beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="Beta-barrel_TonB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="TonB-dep_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47234">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47234:SF3">
        <property type="entry name" value="SECRETIN_TONB SHORT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52016">
        <property type="entry name" value="TONB_DEPENDENT_REC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14977.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14409" checksum="81781504D1433721" modified="2023-02-22" version="1">MWYYDNFAKVRGDVSVGWAISKFTTTVYANYVGSTPNYLAYTGRSYDYVHSSGAKAGKWGSYTTYNMSLNYQAQDDLTLSLMVNNVFNKMPEGQRYNYPGNESTPFNDGFYSVYGRQISAQVKYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4T4</accession>
    <name>A0A914Y4T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane transporter protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4T4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14245.t1">
        <property type="protein sequence ID" value="PSU_v2.g14245.t1"/>
        <property type="gene ID" value="PSU_v2.g14245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31154">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31154:SF4">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14245.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32523" checksum="509DF73461EE34DD" modified="2023-02-22" version="1">MTAEGGGAIAFPVMTFILHLSPKCARDFSLMIQSIGMSLALFVILFMRIQIEWRAITYALLGALPGVVLGFHVIDDLFNGPEKKMLFVSIWAAFAISLYILNREKKRTTVPVIQCFCFWKAVTLMGTGFIGGIFTSFAGSGVDIATFSVITLLFKVNEKTATPTTIVVMALLSQFSFFWRGIVTADIDLDALNYLRVSVPIVVFFAPFGSFLGSHFHRLTLAWLVCILEFVAYFGFLFTLPPWPLLVASVTILFIGFVFFSFLSRAGKRLTEAELGIIDPHAIVPTTDAIIICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Z1</accession>
    <name>A0A914Y4Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Z1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13841.t1">
        <property type="protein sequence ID" value="PSU_v2.g13841.t1"/>
        <property type="gene ID" value="PSU_v2.g13841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13841.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11288" checksum="C2BFC4180A7BD950" modified="2023-02-22" version="1">MITVATFMALDAAYRLLQIEKSHRMPLIVLVSATYNASGFQGTSDLSKNIKGNGTNIVVINFAPENNDLTNALQNIVSPGYYYVSTQQDLYVTIEYAFTQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5Q1</accession>
    <name>A0A914Y5Q1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaminyl-peptide cyclotransferase</fullName>
            <ecNumber evidence="4">2.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23652"/>
            <dbReference type="Rhea" id="RHEA-COMP:11736"/>
            <dbReference type="Rhea" id="RHEA-COMP:11846"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="ChEBI" id="CHEBI:87215"/>
            <dbReference type="EC" id="2.3.2.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutaminyl-peptide cyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.5" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y5Q1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14094.t1">
        <property type="protein sequence ID" value="PSU_v2.g14094.t1"/>
        <property type="gene ID" value="PSU_v2.g14094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000029">
        <property type="entry name" value="Glutaminyl-peptide cyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="58"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14094.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33024" checksum="12730A7C513F0CDB" modified="2023-02-22" version="1">MDTFKQMLKPILVERIVETPSHIKVGQFIKNTVEQYGFTPEWDIFTDNTPMGPKVFRNLIATYDPLIPRRLVLACHYDSKIIPGQKFIAATDSAVPCAMLLDLARTLGPLLHQRSNNHITLQLIFLDGEEAFVNWSPTDSIYGARHLADLWTKKWYPSTDGSSFDLSKEIDRIDVFMLLDLLGTRNPRITSTYGHGTTELFQELPKIENTLRTLGHLKQRPNAFYSGTTFAAVEDDHIAFMQKGTVPFPRVWHTPADNEKALDYDTIENLNLVVRVFVARYLGIIIPFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y608</accession>
    <name>A0A914Y608_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y608"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14200.t1">
        <property type="protein sequence ID" value="PSU_v2.g14200.t1"/>
        <property type="gene ID" value="PSU_v2.g14200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14200.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8191" checksum="42363A37F5F7E866" modified="2023-02-22" version="1">MLGKDSHGWAMYIDDKRLWFYHNHNHDIRVERGHGGNGAVIGVLMDCDQGTLSYYVNDRLIEANAHPYAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y666</accession>
    <name>A0A914Y666_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y666"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13145.t1">
        <property type="protein sequence ID" value="PSU_v2.g13145.t1"/>
        <property type="gene ID" value="PSU_v2.g13145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000028">
        <property type="entry name" value="Integrator complex subunit 11 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="12">
        <location>
            <begin position="246"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13145.t1"/>
        </source>
    </evidence>
    <sequence length="587" mass="66399" checksum="5BA95035523AA3A9" modified="2023-02-22" version="1">MPEITIIPLGAGQDVGRSCILVNINNRNIMFDCGMHMGYSDERRFPNFSHINGGGNLTKYLDCVIISHFHLDHCGALPHMTEQIGYDGPIYMTYPSKSIVPVLLEDFRKVQTDYKGETNFFTSDMIKKCMRKVIPVDLHQVVNVIGDLTIQPFYAGHVLGAAMFLIKTGGQSVLYTGDFNMTPDRHLGAATVLPGLKPDVLITETTYASTIRDSKRARERDFLRKVHEVVKNNGKVLIPVFALGRAQELCILLESYWDRLDLNIPVFFSPGLAEKANQYYRLFIGWTNENIKETFAERNMFDFKHIRPFDLRTADSPGPMVLFSTPGMLHGGQSLRVFKKWCEDEKNMIIMPGYCVGGTIGARVIKGEKKIEIDDRTYDIRLKVEYMSFSAHADAKGIIQLIRHVEPRNVMFVHGENIKMEFLKARVEKDLGLPVYKPANGEKISIPTPTYSTITIPEKLYTKALMLDPNPHKRNCPLEFALVKGDDGTITVTDVDSQIEDTLNSVTFSENVKVDSIDWPGFTKKLKMLDPTLEVKEDGLDLFDSTVLLTHAENQINELEVIFDLSRESTLPKIYELIGARKEEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y686</accession>
    <name>A0A914Y686_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y686"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14276.t1">
        <property type="protein sequence ID" value="PSU_v2.g14276.t1"/>
        <property type="gene ID" value="PSU_v2.g14276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14276.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25317" checksum="BAEA9252AAB18238" modified="2023-02-22" version="1">MRQTRHQINQMQTFWRASQGCQIGIYALHASQAGQGVAALFNQLADALLGQHIHHDPGLFRANGQIHGTAYGGNRAGLTRAPVGQIAGCRHLESAQHTNIQMAATHHAKAVGMMEKRATGQQRHRLLARIDQIVIFLPGGRCRAHAQDTVLAVQYHFHTSGQMVGYQSWHANTQIHIGAVMDVLGDALRQFVFTAALIIERHAVPLHALSVHALNPPASVRLRGTTTTRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6L0</accession>
    <name>A0A914Y6L0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6L0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13284.t1">
        <property type="protein sequence ID" value="PSU_v2.g13284.t1"/>
        <property type="gene ID" value="PSU_v2.g13284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13284.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17483" checksum="BED378346C9173B8" modified="2023-02-22" version="1">MFESGLKESDENKMVIEGFPFEIVDEAVNLCYNSDILPNFILEDKMLLYRFADKYEIKSIMDLVENDLIKIITPSNVVQLIHFSKNFNETKLYQSCINFLLKCSEAHTSVLGIESLDDHFLAMRFLDSLCPVDFDAVDSDDENSDEEDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y811</accession>
    <name>A0A914Y811_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiamine transporter 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y811"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13736.t1">
        <property type="protein sequence ID" value="PSU_v2.g13736.t1"/>
        <property type="gene ID" value="PSU_v2.g13736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF20">
        <property type="entry name" value="FOLATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13736.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36829" checksum="B9EDE45E429A98B0" modified="2023-02-22" version="1">MLGQFFAYSGGQIIYSADWVSYKFLNDFSFGAEIFALGVALICPSVKRKLPEIEIDPIPTSDKSVKTDSNDSVVVVADETKNSSDRNPNPAENVIVNELEAIAPAIVEIPEKKGGFIQEMKESIPKIMSNRVVITWSLWWILTSGMISQLYNYIQILWSTMQDGNNDVYNGVVASVQTAGGAIITFSLQYIPFEWDKHSEIVSFITSIFFGASFFAMAIIWNIYIHYVIFLMTCFCYAILITVAMTVIASQLDAAAYGLVFGANTFFATLLQSLITFAIVDSNGLNLAIRVQFEVYAVCFAVLAIFFLLVRIQKCFLKVETVEEDRTPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8Q2</accession>
    <name>A0A914Y8Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8Q2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15827.t1">
        <property type="protein sequence ID" value="PSU_v2.g15827.t1"/>
        <property type="gene ID" value="PSU_v2.g15827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF8">
        <property type="entry name" value="CHE-14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15827.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35734" checksum="701F7B12033E8EC3" modified="2023-02-22" version="1">MHRELCQLQQFLSPSFKPFTLISPYRQIFHISNFAGCLSPLNRDNCTTLSTYDLRNFKIQLEKCYKSRKAIIQCGRDCIGAKEADGEERHNCQQCERIPSNCTSQMWFDLFYRILPKDLLTRKANNEKIYVNSFLPLYTYSAYGFQGFNVSLNSYIDLEKDLRHWSAHTKELKVKGYLLDVKRDILLASAISDSRLAIVAAAVVFLLVFIYSLSLGYTIAVFIELGASVLMAAAVYRGFSEAFPLLNLVSFVLLLSIGSDGAFLLFNAFPSKSTELDAENFDDCLSHTITTMFLAQFSTIVPFLLNLISSVIVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8W3</accession>
    <name>A0A914Y8W3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8W3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15194.t1">
        <property type="protein sequence ID" value="PSU_v2.g15194.t1"/>
        <property type="gene ID" value="PSU_v2.g15194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15194.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35742" checksum="42A572D97FFAB954" modified="2023-02-22" version="1">MRLKYSDAITKYQKQGCNVLSWLLDQVQFEVDFISPPELGLAQLKRFLKDKCSGFICRECFEAKNQEYFNGQLNYKQAKVGFLRKKKEIFECFICDENSKNEFMKNCGEMDDADVGKEIVFRKSLAVLRSTAIKFHPTVTIQFHDSLDPSLPRSIFQYILQNANHQLLSKIYATAKYFFVKQQILLCYRIQISSTSIITFMEQALFTNAKTLLQLPVKKYCCGTTLTFSSDDKGLLSKCLPKLCFCSLTNLIIDGQNLCLDEFMTLLSGGKMEQLSLKEVRIFKEKNEKIMKIEEIFQVLPPTVTDLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8Z6</accession>
    <name>A0A914Y8Z6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8Z6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15921.t1">
        <property type="protein sequence ID" value="PSU_v2.g15921.t1"/>
        <property type="gene ID" value="PSU_v2.g15921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15921.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18893" checksum="A38C3322E7F77D75" modified="2023-02-22" version="1">MVKWLIEVFNEPTYRPQGVSDLLFAMDDAIVSGHGTGKLLAAKLLLLALRGSIDLLTWQWTMEVFGLGSNTPRTGVSAIGPRMPPNVEFIKLIEDNPNLFENRVPEDVELLNSGYGLKLSYTQCDVSKKVLKDYVFNIQTAHRLNFNVSYETDEDRAEGKNLAFGQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9B1</accession>
    <name>A0A914Y9B1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 18">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y9B1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16026.t1">
        <property type="protein sequence ID" value="PSU_v2.g16026.t1"/>
        <property type="gene ID" value="PSU_v2.g16026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="21">
        <location>
            <begin position="204"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16026.t1"/>
        </source>
    </evidence>
    <sequence length="588" mass="66253" checksum="EA39FAD494AF2767" modified="2023-02-22" version="1">MPSNKICRSDAAINAFGNFMHQTLVERTDILECAYSKEPEDEQSRDRTESSSSCDEEISKKELSVTESVEINHKNDINGNVAERSPNEFEHISKYLRLSVYFSWFTLILFAYIRAFLKRMGFEKNKASTELEKQNPLLLFKIWYTDFVPLYSSFEAIYAQHCYIRVRDVFERPIGSCPGATVKLIDRVTNDFCWSFQFTGTQTEVINVGSYNYLGFAEPNGPCAESAAAIIQKYGLSMCGTIQENGNTQIQDNLEKLVANFIGSEEAICFSMGFATNSMNAPCLVDKNCLIVSDQYNHASLILGCRLSGASTKVFKHNDMKSLEKILRDAIAYGNPKTFRPYKKILIVVEGIYSMEGSLSNLPEIIALKKKYKCYLYLDEAHSIGAMGATGRGVVEYWGCNPKDVDIMMGTFTKSFGAAGGYIGGSKEIIAHLRKYSPTGFYSAPMSPPVVQQVIASMSIIMGRDGTRDGEKRIEKLSRNSRYFRRRLKQMGFILYGSDDSPVVPILLYFPTQCGLWGRELLKKKIGVVVVSFPATEMVEARARICLSASHSKEQLDYVLNAIDELGDFSRSKFSQKTHLYKDLKIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9F5</accession>
    <name>A0A914Y9F5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9F5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15915.t1">
        <property type="protein sequence ID" value="PSU_v2.g15915.t1"/>
        <property type="gene ID" value="PSU_v2.g15915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15915.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19268" checksum="FE431607E7DD8742" modified="2023-02-22" version="1">MFSIAVAGFNQKDLTSSFMGNLVLRDFELSRTGRAIHQIQEQFQCCGFDGPKDWHKRIMFSWEEPGIEEDRTLAYPLHWLEKCASSYVCYSPKSCCTDESLKKSNSTCNQANMTQEAFNDLVDRDFTLLSKRIKPKYRNQINSEGCIDIIGERLKDWSLYALGVSIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9U7</accession>
    <name>A0A914Y9U7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="4">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y9U7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15535.t1">
        <property type="protein sequence ID" value="PSU_v2.g15535.t1"/>
        <property type="gene ID" value="PSU_v2.g15535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="5">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="5">
        <location>
            <begin position="131"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15535.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38041" checksum="6E2678F1A48CC638" modified="2023-02-22" version="1">MTVAAEFKIEYLQYLDADGKLVRDDLPASLRDPKVLVPLFKQMLFVRTFDSKSIALQRTGKLGTYAACLGHEAAHVGIGAAMQKDDVFAPSYREYGAMFMRGVRPHDVLMYWGGDERGNDYGGNAAKDSRAALKFKLNKEPQIAVAVCGDGGSSKTDFYAALNSAGAYKLPLILCIVNNGWAISVPRSAQTGAETLAQKGLAGGLHCLQVDGNDLIAVLAAMEQARERALAGDGGTVLELMTYRLSDHTTADDARRYRDDAEVKDAWQREPMLRLRKYLINAGVWSEEEEAAWTAECGTRVDEEVNLYLNTRVQPVEAMFDFLYADPPPDLLAQRAQAIALEKRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9Y0</accession>
    <name>A0A914Y9Y0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Musashi family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9Y0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1557.t1">
        <property type="protein sequence ID" value="PSU_v2.g1557.t1"/>
        <property type="gene ID" value="PSU_v2.g1557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12576">
        <property type="entry name" value="RRM1_MSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12323">
        <property type="entry name" value="RRM2_MSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000020">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034126">
        <property type="entry name" value="MSI_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF18">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="56"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1557.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39385" checksum="74417055A0DF111E" modified="2023-02-22" version="1">MLKNNGTVSTPEETSSKSSIPKSVASDSESIDKVPIMDEEMHSPSMELEGSDQDPGKMFIGGLSWQTTAEGLRDYFSKFGEVNECMVMRDPATKRARGFGFITFAHPNSVEKVLAEANHELDNKKIDPKVAFPKRAQQPKVTKTKKVFIGGLSSTSTLEDMKNYFQQYGKIEDAMLMYDKATQRHRGFGFITFDDDDVSDKVCEIHFHEINGKMVECKKAQPKEVMLPVQINKSRAAAARNLYGLAPEHLLAYASYMPRLPAYTGSMLYPGIFNGFTQQYGISPSGRSSISNNGGGNINTSNVSPRDLAAAQSLAQQHAVYEAAIAYAQNVADMPMTFPPQAQLGHQQPITNSFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBJ0</accession>
    <name>A0A914YBJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBJ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16783.t1">
        <property type="protein sequence ID" value="PSU_v2.g16783.t1"/>
        <property type="gene ID" value="PSU_v2.g16783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16783.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10935" checksum="C6CBB6FDE63B7D52" modified="2023-02-22" version="1">MKLKYLGTLLDSLDGVAKIRAIAVAPNNRKVAIATADLNIVLFDDKLQKKDKFATKPVDSKFGKKSYIVTSLVFSPDSTKLAIGQTDNIVFVYRLGESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC68</accession>
    <name>A0A914YC68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15071.t1">
        <property type="protein sequence ID" value="PSU_v2.g15071.t1"/>
        <property type="gene ID" value="PSU_v2.g15071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15071.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9065" checksum="ADC14F0D47B00A20" modified="2023-02-22" version="1">MQPPLPPPPPPPVVIKAKRPKPSKQPKPSKKKPAAPASKLEAPPAEKPPIEKEAAEGGGGEEEEGGDEEKDDGNETGTGTDNMKPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCS6</accession>
    <name>A0A914YCS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1655.t1">
        <property type="protein sequence ID" value="PSU_v2.g1655.t1"/>
        <property type="gene ID" value="PSU_v2.g1655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="81"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="228"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1655.t1"/>
        </source>
    </evidence>
    <sequence length="467" mass="53666" checksum="8F61561AE9F1605B" modified="2023-02-22" version="1">MSAWYAHDYQPDLSFEYVDNHCDIKHDFSSYPLECKPSSSIGRSSVFSSTTDDSSHVKSGRSTAECDIKPDVIEISTEKAPRECVVCFQPTSCYHYDVPACTGCKTFFRRCLVTNREYKCQYGGHCDITQGQDCKGCRFERCIISGMNAAAIQYPKTVDGKKIVEKVKVLKRKIIEDNKPVVSKMLPAFSQTKERQEIDFLLYLEAKQRRLRESTYNPQQLFRTSLRDLLQKSSELSLADKYEKPSEWPMNQQAITERIKKGKEEIKRSGKYFVGCDLILTIEVAKILPAFNFLTLDDQEALMRHVVVVNMVLTQSFYSYLQHLDVIIYPNGVVPVKMDEIFGRVPMQVKIETHTRSVQSLSRTSITAEQFVLLKAIIYCHPACDNLSSEGREIITKYHERYSGILLRHLQDEYGNQAGASKYGSLICLIEAYFHFAEKSKQIHLMHKINRKCMNHSCMTLVEECMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDB2</accession>
    <name>A0A914YDB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16736.t1">
        <property type="protein sequence ID" value="PSU_v2.g16736.t1"/>
        <property type="gene ID" value="PSU_v2.g16736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="87"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16736.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23777" checksum="DF0F3985BD7CE5BE" modified="2023-02-22" version="1">MGNRHSSHGGGGGGGVKPKKQRVVPIHEPGNKKQNFLCNLFAKSRFDPAALAATCPPPVGGEMPVGEATVLRDRPALRLDSRLVCKYEVLSVIGKGSFSQVLRVQHRVTKDFYAVKLVSSSSDFGAVNNELSILSRVQHPFVIRLEEVFRSASKLFIVMEMASGGEMYDRVVSKGRYSEIEARQAVRMLLNGLAYLHSSLQITHRDLKPENLLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEI3</accession>
    <name>A0A914YEI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEI3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15800.t1">
        <property type="protein sequence ID" value="PSU_v2.g15800.t1"/>
        <property type="gene ID" value="PSU_v2.g15800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15800.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="28879" checksum="C1A6BD5DF5C5FB2B" modified="2023-02-22" version="1">MMLQLWLFHYKLKNNANTAENEDVTTATDILTTNAQASTTISIKETIVPVTVASVEANVDDATTLNNGETIISSDQTTLASANAETTTAKPESIIILPIEGSKNVASTTAQPEDVKTILSTLLSSSASTTQSIEIETTEKQVVEQSTSNPSSAEQKTLAKVADIIESQEQKSESETSSTSVNPVDVAVLNVDDTLKNEDPKEATTVSNVDEAVAKVINFLNKNEISTTAEADETTTAVPEGERDNAIKNMLDRAKEVVKIPSTSSTEEPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF43</accession>
    <name>A0A914YF43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cadherin</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g1807.t1">
        <property type="protein sequence ID" value="PSU_v2.g1807.t1"/>
        <property type="gene ID" value="PSU_v2.g1807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
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        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034243">
        <property type="term" value="P:regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000002">
        <property type="entry name" value="Protein kinase C-binding protein 1 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057053">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047269">
        <property type="entry name" value="ZMY11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24324">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="14">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17808.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20459" checksum="5C17C39C0D77D4CF" modified="2023-02-22" version="1">MDEILRDDNQDMNDDMSGMLMDERLKKPLYDLEHHWLAEYMEARERLLCTLTEKMHAEFLSDQTKIRNELLAQFKDELETTKKDLEKKYEDQLKSEVTKVGERHKRDTSQAKKKQWCWQCESEAIYHCCWNTAYCSVECQQSHWNSHRKFCRRRNKGGENGPGPAGAPLNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGC0</accession>
    <name>A0A914YGC0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WAP four-disulfide core domain protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Putative acid-stable proteinase inhibitor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGC0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19346.t1">
        <property type="protein sequence ID" value="PSU_v2.g19346.t1"/>
        <property type="gene ID" value="PSU_v2.g19346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050514">
        <property type="entry name" value="WAP_four-disulfide_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441:SF39">
        <property type="entry name" value="WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441">
        <property type="entry name" value="WHEY ACDIC PROTEIN WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51252">
        <property type="entry name" value="ANTISTASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="WAP" evidence="9">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="9">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="8">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19346.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31320" checksum="009D9CF9E694A513" modified="2023-02-22" version="1">MGTWKYVFMRVSNGSMFVSSSQRQYFTTTLGECPKLVGGLCIERCKTDSDCSTQMKCCSNGCGRECVLPVHVAPIMNQLPIQPLQSNLAPKQQQNTNFETTIVGNNIHRFPEHSNFNPIKKIDKVGHCPMKAVLKDQKCEVECNRDSDCSGVAKCCDSGCGRSCAAPERATSCIHLLSAVERLPSKQLNDGFVPFCSSNDGLFEQIQCDLVRQTENQRQCLQDNCKSKTCPFGLRTDANGCPISPCECKNICDSVSCDNKLDECQLVEPDCAKTSMFSCTKMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH41</accession>
    <name>A0A914YH41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH41"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16625.t1">
        <property type="protein sequence ID" value="PSU_v2.g16625.t1"/>
        <property type="gene ID" value="PSU_v2.g16625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16625.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36705" checksum="80E8F5A056B71860" modified="2023-02-22" version="1">MRKHGPCVTGAQRLINYLTAKINLKDTNVDLTVLPQIGDIVNSKTQSYKVISIISRSCFGAIFEVQNINSNIRYAMEVAIVDGIEELKITCNVLQKIIEAKSSHFCKLIDHGKQQKSFKFIITTLGEKNVQQLLENAERISIQTSVALAKQSLDAIVDLFKIGYLHRNIKPSNFILGKTGKFHCVRLVGLGLVEKYTDEETTRRPLVDHLIGNLKYGSLAALMGQQLFYKDELESWFYLICVLFNATLPWQNNANICEIIQLKEFLKTDKNDVKNQLMQQVPVELKNIFQHLSNLNGNELPNIQLLHESLDSILKFFIFIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIC8</accession>
    <name>A0A914YIC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome maturation factor RimP</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIC8"/>
    <dbReference type="SMR" id="A0A914YIC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1707.t1">
        <property type="protein sequence ID" value="PSU_v2.g1707.t1"/>
        <property type="gene ID" value="PSU_v2.g1707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.180:FF:000001">
        <property type="entry name" value="Ribosome maturation factor RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.70:FF:000001">
        <property type="entry name" value="Ribosome maturation factor RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.180">
        <property type="entry name" value="Ribosome maturation factor RimP, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="entry name" value="RimP-like superfamily, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
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        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000927">
        <property type="entry name" value="PRK00092.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="RIBOSOME MATURATION FACTOR RIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867:SF1">
        <property type="entry name" value="RIBOSOME MATURATION FACTOR RIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="RimP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="YhbC-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="YhbC-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation factor RimP N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation factor RimP C-terminal" evidence="4">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1707.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15490" checksum="005EE61FD538ADCB" modified="2023-02-22" version="1">MITAPVEALGFELVGIEFIRGRTSTLRIYIDSEDGINVDDCADVSHQVSAVLDVEDPITVAYNLEVSSPGLDRPLFTAEHYARFVGEEVTLVLRMAVQNRRKWQGVIKAVDGEMITVTVEGKDEVFALSNIQKANLVPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YID1</accession>
    <name>A0A914YID1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g20092.t1">
        <property type="protein sequence ID" value="PSU_v2.g20092.t1"/>
        <property type="gene ID" value="PSU_v2.g20092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="908"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20092.t1"/>
        </source>
    </evidence>
    <sequence length="1174" mass="134518" checksum="A17B68E246EBE756" modified="2023-02-22" version="1">MGGKIEIRKCQYSRKKCYSIASPSSRFCTLHEENRIMCRYICPFTHVQCNYSSLETSGFCDVHKRVLDRKRQRYNAFEQKYCNKLPAYKRENEVDFVEGKINNYVDYARYVDLLSRPGAPSPLSNAGIYSVPEIENLKDAANDILRSRLNETRNLYQQRAHSAAHALDEELKERSRNDEKFTVVTNSSAEIAVSLQALIDRHQQKIEELPPVDKDEISHPSQRQKLQTDVDYDMKNSDNFCHYSEIRRKVASSFIFHNQENQKEGPVEEVVQQVMNSVLNILDKNAEPVAYQYEDVCTNQKIKGFEHCFKHLWKEASALKKCAECDSTCTLASNICGKCLKPYLDVKTENMVCFSDDDEGIATVSVGTTDNDLNAVLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDLNAVLTECAKKLKAFTEVEKDNDLEITSPHKFDSKNLAEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNLAEEKRLEFMWGDMLKFGLECEDVTFAKEIKINDDDLPASKEYIPLQYNRSYDIDKIIATPSDETSESEAEPITFCQEGVKKPIVCRFPSRTLSEKVAAHTDKTLDIAVGIEDPSQLPVQFRPVPVAPSQSSVNTVQNQSQTGRIPRPTYYPTSTANTIRLIKDVNPAARSNHQFLYTPNNRQVITNTFVQNPRSSTYVRPLRLLRPPPAVKYVYHYYPANQSATYIPSSVPIAYPSGNPSVKYAQSHVGPPVTYTRIYTPHDPATQYPPTYRRYQLLMKCQQRLEQWNKELRDEWAVISDRSELEFEWPVNTPLEVRELVGPEHFDAASPKYLMPFFWRSDAVPATRSWGIVVCGIECGFAMVCTLFNLIHFSIFLPRFEGGALPSIVFFITVFQLAIFYSVKVLFVISVIGKHARLLRMQLLFQYVTCVFLLLNAAFTLAADFGGYNEEQIYAQRNPPLIRFIAFLSLIFLFVQLFLRLMTIPVFNFMNDLRKFKAAIYNSQWRYRKRVYFTYCSLIHETEQEERKNKQALEILNESEATPPQIRTCPTIITINDSPPSSFSNTLPHVPLLDYDTKEKESVKSQETSSSETGSLQAVHPPPRRRQQQLFVRRPRIRKRGIPHRIAGSKNFEIRVELDNTDIQKLLNAYSEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ63</accession>
    <name>A0A914YJ63_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914YJ63"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19344.t1">
        <property type="protein sequence ID" value="PSU_v2.g19344.t1"/>
        <property type="gene ID" value="PSU_v2.g19344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="62"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="577"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19344.t1"/>
        </source>
    </evidence>
    <sequence length="774" mass="84029" checksum="1E0B7D14D68A0D03" modified="2023-02-22" version="1">MLTFRQIPGQVQSVRGLHGSFGCLSKVSMSKFETDKYLPYEKLDKNLEIVRKRLNRPLTLSEKILYSHLDDPKNQDIQRGVSYLRLRPDRVAMQDATAQMAMLQFISSGLPNVAVPSTIHCDHLIEAQVGGDKDLARAKDLNAEVYNFLASAGNKYGVGFWKPGSGIIHQIILENYAFPGLLLIGTDSHTPNGGGLGGLCIGVGGADAVDVMANIPWELKCPNVIGVKLSGRLNGWSSAKDVILKVADILTVKGGTGAIVEYFGPGVDSISATGMGTICNMGAEIGATTSVFPFNSSMGKYLKATGRDQIASQASKFKHILSADANAHYDQVIEINLDTLEPHINGPFTPDLAHPINKIGAAAKKNDWPMDIKVGLIGSCTNSSYEDLGRAASIAKQALDKGLKSKTAFTVTPGSEQVRATIERDGFSKIFSDFGGVVLANACGPCIGQWDRKDIKKGDKNTIVTSYNRNFTGRNDANPQTHAFVTSPEIVTALSIAGTLDFDPRRDELTAADGSKFKLKEPSGDDLPARGFDPGVDTYQSPSMSGDVKVDPKSDRLQLLEPFKAWDGKDFEDFVLLMKVKGKCTTDHISAAGPWLKYRGHLDNISNNLFLTAVNAENGEMNNIRNQVTNEFGKVNDTARDYKSKGINWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFDNPSDYDKVQPSDRISIVGLTSFAPGKPLKAVLKHKDGSKDEITLNHTFNEQQIEWFKAGSALNRMKQVAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJC6</accession>
    <name>A0A914YJC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJC6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20439.t1">
        <property type="protein sequence ID" value="PSU_v2.g20439.t1"/>
        <property type="gene ID" value="PSU_v2.g20439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOS1/NGEF-like PH" evidence="2">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20439.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16771" checksum="BA8EE73CFF3194D7" modified="2023-02-22" version="1">MQKALELIQSIPKRANDSSITDNIQNYQGDTNRLGRIYRHDLFQVWEGDEPVTDRYIFLFKNKLMFTDKDAKIDPPSFKHYSTIRLDKYTARVHTGDEDAIVLRPNEPGLPSFRIKAKDQQSQEFIRKAWLKDINEMQDAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJG9</accession>
    <name>A0A914YJG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g20486.t1">
        <property type="protein sequence ID" value="PSU_v2.g20486.t1"/>
        <property type="gene ID" value="PSU_v2.g20486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20486.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28383" checksum="FCE56CBC17094736" modified="2023-02-22" version="1">MADEQEQPRRQRSGREIRPLNRLSPDPRERPNRVRSADDARRLRSRSRSPRNQNINSRSPSPRPNAEEHAAQFLQREAARQQNAEPQNNYIVVSNGVYVFSCPTNNVRGTGRFLTLKVRTAGRWIVQAFPRPENANVLQAARENLNAVAIGIRTDNLAAQQTFAATIRTETTAVLNRMREENRALAETMATNAENMMAGFTNALNAFAQQFNANGAQMAFNFQAAPLHDXNPNWNSKMQIDWMTVSKTLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKF7</accession>
    <name>A0A914YKF7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YKF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20004.t1">
        <property type="protein sequence ID" value="PSU_v2.g20004.t1"/>
        <property type="gene ID" value="PSU_v2.g20004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20004.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30971" checksum="5EEE501E58825546" modified="2023-02-22" version="1">MVLHLIGLGLGDIKDITIRGLETAKSCSKIYLEMYTSILSYGLDRTELNKAFGKDVIEADREMVEQLADQVLDEAVSEDIAVLVVGDPFGATTHADLVLRAKQRGIKVDVVHNASIMNAVACCGLQLYSFGETVSVVMWTDGWQPESYFDKVLSNFERGLHTLCLLDIKVKEQTVENMMKGNKKYEPPRYQTCSEAAEQFLKICERRQERSEACLINAETPVVGLARVGWKDQHIASCTLREMTLVNMGAPLHCLVIPGKTHPMEEEMLQTFAISKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMJ8</accession>
    <name>A0A914YMJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2156.t1">
        <property type="protein sequence ID" value="PSU_v2.g2156.t1"/>
        <property type="gene ID" value="PSU_v2.g2156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2156.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11030" checksum="ABD7735E85F5134A" modified="2023-02-22" version="1">MRRTQSMGDLLLISPDIIIKGPQPDTKGPPTNDDGWLVKIRTNRYLENARNRLPSRTRSVGDLSRTPKQLFASDRIQISQTLQKVTEDCIPKLVLMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN10</accession>
    <name>A0A914YN10_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914YN10"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20781.t1">
        <property type="protein sequence ID" value="PSU_v2.g20781.t1"/>
        <property type="gene ID" value="PSU_v2.g20781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20781.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13140" checksum="4A2654B041ED3249" modified="2023-02-22" version="1">MPIVKLYTNHKVTENFGKDFSAFLSTTLNKPSSGLFVIVKDQEALTLGGESDDRIVVLELKAVGILNNTSNIGFSRAITEYLTQCIDVKPERCIIDFVTLDPGFIGRQGTTVEELLKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN28</accession>
    <name>A0A914YN28_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Programmed cell death protein 10 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YN28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2289.t1">
        <property type="protein sequence ID" value="PSU_v2.g2289.t1"/>
        <property type="gene ID" value="PSU_v2.g2289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 10 dimerisation" evidence="4">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2289.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20237" checksum="C99E5AE133D05B8E" modified="2023-02-22" version="1">MNDFRSASSHVATYQQQQPKESQPPQQRQHYIRHQSRGSADSGGSGGAARKTNGYPQVPVHGGGTSTTSIEIHNNGSSPTSIPRDRQERRQAPSRPPSSLECAVLPALDKLSRTRHGGATDLQALATAFRRAEQMSPGICDHLITELITTLAYPQVSNSELRTSIDRLTTSRHGLRPNGHHSESSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP45</accession>
    <name>A0A914YP45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2618.t1">
        <property type="protein sequence ID" value="PSU_v2.g2618.t1"/>
        <property type="gene ID" value="PSU_v2.g2618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2618.t1"/>
        </source>
    </evidence>
    <sequence length="446" mass="52168" checksum="2549A81E30525197" modified="2023-02-22" version="1">MNQRIKDLPIGEEINRKLENFEDSVIVITLKRRLISGSDFDPIDTDELLELLRCLFKDNFNTENNEDEVSEDLTKRIIHRISKFYAIPMNQIRLLMIGVALEQELNQINFELTRDMIKRSFPKLKTASLLREPTSIPAALYLSKQILKYTTKVIERQSDTLFLPIGTESSVVFFAFCHYLTPVLDLCHLNLWEKAEVCGIKDSLRDLFCQSIETSVMEWIHEFNSRKDDADFICQKIDEIHICFRRFSKNYNEFFEKAFFSYSEYVLDLIDSDITDAVQNAVETLTDSVEPRNRQKLVSFTRSTMKLFDALRQFTEFIETLSYANFLKIKGEGPKEYRIHGFEMAFEKAAVFWTSTWRSVYLNFVRRCIEVSDDGSSYPPNSPNFEEKTTHFFQSKVQEPPEIDLHPSTINCLAFCKALCDDFLRLKINAQNTMLLCCLQIVNVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPA4</accession>
    <name>A0A914YPA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20823.t1">
        <property type="protein sequence ID" value="PSU_v2.g20823.t1"/>
        <property type="gene ID" value="PSU_v2.g20823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20823.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7891" checksum="62E6AF30D85B7D81" modified="2023-02-22" version="1">MPLYKSQVEKVVVYVVESKNQTGWADFNPVRIRHLICKMAAESLPQAAPTIPCPTVITVLPTKISKKSCHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPU8</accession>
    <name>A0A914YPU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPU8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19391.t1">
        <property type="protein sequence ID" value="PSU_v2.g19391.t1"/>
        <property type="gene ID" value="PSU_v2.g19391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19391.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40033" checksum="99E2AFD7F88F7F7A" modified="2023-02-22" version="1">MQAPDKLELKDAYYIATQQGYATPDVIELCSNAVRTLNYRKWILCWLEQLMKNNCSDELLAASELILATLFLRPVTALAEITQRLMDLMLTQNKQNNKINLSNQTCPRIFAWLVVRAQTFLIFAEQIRREKESAKKMLREKSQQNFVMLMTTSSSSITRMEESEENEPPAKKSRIDNNTDDERSNMTATAAEEETPREDSQMASNFNATAANTVTVNEIIASIEKEQSSTIFDDDKDYKIRQDFELDDEPSPIDHSNEWTLSKRIHQINEDAFMNLSNIMQHSISMSVITISISLRRFEKQIKVPVWRPELLFTIHFAQELARVPRSRFWYKLVYVLAKPQFVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPZ6</accession>
    <name>A0A914YPZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BRO1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BROX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPZ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2893.t1">
        <property type="protein sequence ID" value="PSU_v2.g2893.t1"/>
        <property type="gene ID" value="PSU_v2.g2893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038898">
        <property type="entry name" value="BROX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032:SF13">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="9"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2893.t1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48009" checksum="303A8785005E527B" modified="2023-02-22" version="1">MSHWFHRNPLKATEFAKFDLKHVLKNEHSSKICGELRLRRDKFLKHLESASSDLEQVETEFNQYLSLLYGFLFDITADGDKESKLRYLLRPTWGNSMIEKDGIVLSDSWFEALNMCYNMALWYMKHGAWVSAKDEVKDSEAKTAHCCLKKAAGLFEFIKEKTDLLCGLDDFPGNDFNMNVIKSYLNQSVAEAQEIAIARAIELQHSPSLISKLATETARIYHEIDTLLEKFNPSTFEKWRCYAQLKNKFYLSYAYCYRGEALLAEDKCGEAVRSCKEGIKCYKEAEEICVKYAKSSGPGFIAKPEKHLFFRRIQPLLERHLEKAERENGFIYHQIIPDALPSLEENASFGLAKPEAFVYPKKSDAWTLTAYDAFDISKADTPDFSKAKKSKKSLPTVKEEKVYQTDRDPKNVSGCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ77</accession>
    <name>A0A914YQ77_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g19514.t1"/>
        <property type="gene ID" value="PSU_v2.g19514"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19514.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15229" checksum="9244DECA5EF8B495" modified="2023-02-22" version="1">MASSSSYIIDETTREAFFDTMEIDEYSTSTTTTKNFEELLYDSGISSDSLSSSDSSFSSCCSENLYVTTTTTVGPTNFGEICSKKSPELPAEYSQDLDEDEKCATDSLNSSWDFNELFRAEPCGRRSPLLDLSNSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQN4</accession>
    <name>A0A914YQN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQN4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g249.t1">
        <property type="protein sequence ID" value="PSU_v2.g249.t1"/>
        <property type="gene ID" value="PSU_v2.g249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g249.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15851" checksum="357116AC9D685B3D" modified="2023-02-22" version="1">MSSNEFKTLITTFGTKSSEVEELSYDASQVIVDFCDQEDITHREVNTRFKEICEAEYYRLKNAPVQVEDFPPKIDTENFRQKLNESKIAKLEKKKREKDIKQKIEEQREKIKEMEEIFRKKLEIINSAKQLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQY6</accession>
    <name>A0A914YQY6_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21490.t1">
        <property type="protein sequence ID" value="PSU_v2.g21490.t1"/>
        <property type="gene ID" value="PSU_v2.g21490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21490.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10747" checksum="4A037FA66ED7F002" modified="2023-02-22" version="1">MFMGFNSGPSTSHLLEPLQHPQIINNNNNTLLNLPSTSVPLLPPRPSSSSISPSGSVSNGRISKKKGALECDVCGDTALGKHYGQKNKEMRVELVDFVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRB1</accession>
    <name>A0A914YRB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRB1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g255.t1">
        <property type="protein sequence ID" value="PSU_v2.g255.t1"/>
        <property type="gene ID" value="PSU_v2.g255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g255.t1"/>
        </source>
    </evidence>
    <sequence length="493" mass="54233" checksum="0AFAF51F9DC9B00F" modified="2023-02-22" version="1">MMKSDDELEDEIRTSEKESSTKGSLKSKKKKAQRKRKSSTTSRTSKVSKKSKPVKVHLVKVEKLEGKHHPKKHLKQHSEASQQEVAETVDAAKCCFVFAYMVQTAIFIANIIAGITAYYFMKNESILDAFGYLAFAQFEFSMVIMFGICVLCCRCFSVVNCILLSLCELGYAVYVTVIDMHDECQEFGCTSLKGDILHRIIFVSTLLIFGTIHAIMAASIPAALCVTPTKAKSTKVESIQKVEPVQSLRKRRQSVSTSRSRSHSRSVSSKRRSAANPRHIAKKVPIDHESTLSWSTLPSSKFLSTCPSNSSQKLSSNSSCPYSASSVANSQAINQQQQPLQQQQSYPYYNYPGSDTIAVTFPSATSVNAPEYQSVTVRMPIYGYPPVYYPQQPQVAYYPSQAASGAASQNQHVLVSFPSSAIAPPPPPHHASNVSAVSIQTAKCIPNESDSSFYNLSQTSENHSIVLPNSFASRDSMNGSQGIFTGNTPKHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRY9</accession>
    <name>A0A914YRY9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dystrobrevin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dystrophin family. Dystrobrevin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g242.t1">
        <property type="protein sequence ID" value="PSU_v2.g242.t1"/>
        <property type="gene ID" value="PSU_v2.g242"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16244">
        <property type="entry name" value="EFh_DTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017432">
        <property type="entry name" value="Distrobrevin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF27">
        <property type="entry name" value="DYSTROBREVIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038204">
        <property type="entry name" value="Distrobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="463"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g242.t1"/>
        </source>
    </evidence>
    <sequence length="638" mass="71527" checksum="164F6EE917874022" modified="2023-02-22" version="1">MWTTTNGGGGGSSSNNNIGGGMMIGNDEITIIPRQNSATPANNGSASTAAAIAVVDGGEELQALVDEMRMQDFDSIRFATYRTACKLRFVQTKTNVHLVDIWNMIESFRENGLNAMAMNSHLKISRLELLLTSVFHSLNKRLPTAQHIDTDKSISTLLAFLLGAFDRQRIGRLTVFCVKVAMATLCAGKLVDKLRYIFSQISDTNGIMEHIKFAEYLQYVLALPTSVFEAPTFGFSEAALNQCFKRDESINLNHFLDIIMSDACPPCLMWLPLLHRMAAVEHVYHPVVCDSCQVRAFTGFRYKCQRCPNYQLCQSCFWRGQVSKQHKNDHEMKEYSSYKSPTKQLAHSIHKSLRCIPISSQKAHKEYPNKPQRPLDLANLVPMTPNSLRHNPIEPITEWTTKLLPGQYGQVGNNEDEHRLIARYCAKLAGRSAFPSTSTQNQNQNLPQNYPPDSNAASAFQESFEERAMIAQLEEENNQMLREMASLEEQQQGGINGYPPDLNRRAELEAKMRIMQQTRRELMTQLQHLMEQLNTNTTPRAISLGQLPEPLSGVGSMISTAFREPSTQSQMNPTQQSNNNFRASSLPFNQLQEDLLHAADAISNNMSSLVVELSSVDDMTTMGMPSSMMPGQEPPDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT01</accession>
    <name>A0A914YT01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LRAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3127.t1">
        <property type="protein sequence ID" value="PSU_v2.g3127.t1"/>
        <property type="gene ID" value="PSU_v2.g3127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053372">
        <property type="entry name" value="Vulval_toroid_morpho-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36948:SF1">
        <property type="entry name" value="EGG-LAYING DEFECTIVE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36948">
        <property type="entry name" value="PROTEIN CBG04856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRAT" evidence="1">
        <location>
            <begin position="137"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3127.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30115" checksum="75C3B074FC7B817A" modified="2023-02-22" version="1">MSVFEADVPRSFRVYVNEELEKEWMGDEIERSWGKTHLGQYFCFITSKVIWYGVRLIIDEEYRNLEIKRERGVHRVGHGVVIKKDFLTREGATDFVLQNTTKYGNGEFNDYFFRARAVPNDVHENPDMYLKPGDHVQRDLDMLFFSHDGIYLGNGKVAHISGGSSNSASNSSSSSCTCMININDAQEACARIVTLKEFVLSDKQEVRIVVHCFRRKSRTEICEKARELVAERYGYGNYNILSKNCQHFATLCALGEECLTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTH5</accession>
    <name>A0A914YTH5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Trafficking protein particle complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Golgi apparatus</location>
            <location evidence="2 10">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTH5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3298.t1">
        <property type="protein sequence ID" value="PSU_v2.g3298.t1"/>
        <property type="gene ID" value="PSU_v2.g3298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000005">
        <property type="entry name" value="Trafficking protein particle complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3298.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21649" checksum="B83435B41831CAE1" modified="2023-02-22" version="1">MLQRSKTVGILDKSLSKGKTEINLSTYALLFAEMVRYAQNKVNTVQELQEKLADYGKFVGVRLLDLIVLREKSYKRDTKLLNMLMFVKGTVWKNLFNKEADKLERSNDDPCKYFLIEKDPLVNTFISLPKDKSNLNCAWFIAGIVEAFLTESNFPCKVSAHWHKGTAYMIEFDPDVIARENALLESNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUT7</accession>
    <name>A0A914YUT7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g21250.t1">
        <property type="protein sequence ID" value="PSU_v2.g21250.t1"/>
        <property type="gene ID" value="PSU_v2.g21250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="2-oxoglutarate dehydrogenase E1 component N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21250.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15901" checksum="69ADAC843C14C7BC" modified="2023-02-22" version="1">MSSQKDCSVTLIVGXNAPYVEELYESYLDNPGSVADQWREYFDQLQHQPATDGRDSTRDQAHAPIVESFAQRAKANAFLTSAQAPDLTVAMKQVSIQSMIAAYRSLGARIADLDPLKRSERPSIPELDPAFYGLTEADLDQPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV75</accession>
    <name>A0A914YV75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV75"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21409.t1">
        <property type="protein sequence ID" value="PSU_v2.g21409.t1"/>
        <property type="gene ID" value="PSU_v2.g21409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21409.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="16262" checksum="CF0F1A728B17186C" modified="2023-02-22" version="1">MAQVGEQALVVGALQPGQFRLVHARGPEGEPDAHRGAVDLAVVEVAIDDGAQLVARVVADLGAVAGDGVLQLAQDLPHCSIEQAVLVAEVVGDDPAGQPCLLRDGGDGRIGHADLVDGLESGPDQLFAPYRFHAFLRHCLSTDCDPKDRAAGHYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVA5</accession>
    <name>A0A914YVA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVA5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3598.t1">
        <property type="protein sequence ID" value="PSU_v2.g3598.t1"/>
        <property type="gene ID" value="PSU_v2.g3598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3598.t1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47421" checksum="D39B344BC90EE92A" modified="2023-02-22" version="1">MILVNRNDPTNFSIVAIPCLTEFSTLTGESINYSIDEELPGEFVDIYALHGEEIFGVILTSQTADQIIQLIWKLNKENERVECIVERRFSFKGVLNCRIGIGTIDTKCILIIGKSSVENGEAIITRSIAANPFQINKYPDKCFDKEIAELEQLCKNHPNELLLIPNCVPFINENGIFYLLGKVCDTNLIFETQFIGSIRLTNNGSNVEIITVKGESAVKSIRKLIERDLLVGWCSYVTQRKTTAWMSFVVQKASGHWRYKLQHIALLACGILIRYIGKPLVSLSWLDGGFMANIFANLYMWLIPGLVPNFGPTPDLVLLALDLKNWQFRHIPFLGNEAEFRSLSSQIMVDSTSNGSLIATEVTSYSRRMRISRLSNPFRIKPLYESAFEAATNLNPTLSKNPSLLRLQKIYNSSGCTLFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWG6</accession>
    <name>A0A914YWG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="24">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <location evidence="16">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g4.t1">
        <property type="protein sequence ID" value="PSU_v2.g4.t1"/>
        <property type="gene ID" value="PSU_v2.g4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000145">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000209">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000035">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056588">
        <property type="entry name" value="EGF_LRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24468">
        <property type="entry name" value="EGF_LRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0168">Coated pit</keyword>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="4379"/>
            <end position="4403"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="364"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1327"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1370"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1414"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1458"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="2021"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="2066"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="2389"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3093"/>
            <end position="3108"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="4149"/>
            <end position="4192"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="4349"/>
            <end position="4360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="4513"/>
            <end position="4546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="4523"/>
            <end position="4538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="19"/>
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            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
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    <sequence length="333" mass="37962" checksum="4D326A385703B647" modified="2023-02-22" version="1">MTTKSKIVVPASSKFSLEQFIARHQKYKAKVEYKGEEIEELIEISRSVIQQESSMLEIGLPINIVGDIHGQFADLQRIFNAIGYPGPSRYLFLGDYVDRGPQSLECICSLLAYKIAFPNRIYLLRGNHECEVINRAYGFWDELQRRFALGIAMKLYKDFNELFSYLPLSAIIRGRILCMHGGLSPRLSSVADLKRVRVPFSDPPQNSLEQDLLWADPKYDLKGFEFNKLRDVSVQFGEDIVQKTCKKLGLDLIVRAHQVMQNGYGFFANRKLVTVFSAPKYLPEMNNRGAVMKINSQMVISFVLLNPTEKDSAGAENFRSSFHDDLTSYTCVE</sequence>
</entry>
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    <accession>A0A914YYP5</accession>
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            <fullName evidence="3">EB domain-containing protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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        <property type="gene ID" value="PSU_v2.g4758"/>
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        <property type="entry name" value="CE4"/>
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        <property type="entry name" value="EB_dom"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="156"/>
            <end position="207"/>
        </location>
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            <dbReference type="Pfam" id="PF01683"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4758.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="23625" checksum="5B8C1413D5FDF58F" modified="2023-02-22" version="1">MQSTNDGQSCTFIDRNCTNKGSIWIAELGECKQVISPGSGPCSHSMQCSAVVEGAHCFLQKCTCPSNLPVATDGTCGFNCSQGYVFSAVTGTCLPIAQPGGDCLYSSQCHSIYPGMLCDMNRCRCPNDEVFSGTRCTSSCPRGYMKNQQGICQPGCRGNQIEYNGDCLDRSVPGQSCLVNRQCSGGSVCTNEICTCPQNMVNSNGVCAIGKKILLCCCFLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ23</accession>
    <name>A0A914YZ23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ23"/>
    <dbReference type="WBParaSite" id="PSU_v2.g536.t1">
        <property type="protein sequence ID" value="PSU_v2.g536.t1"/>
        <property type="gene ID" value="PSU_v2.g536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g536.t1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47859" checksum="86FF2AB8D9905CB6" modified="2023-02-22" version="1">MKISSTLNSTPPTSKDGNVRRSFNFKNLFSAKSTTSSKHQQTPPSLTKSPTSLLQRTASTIKFRKDNSSISPPKLSTLDEDDDRFDAISQASTGKLVMRKGEQRPWRNFFTRSFISSTDSNKKEDEENEEHYENHRAALQSPRIAHRRRVSVIGDVECDRKIFANKYAAFAPSPADCRKLDLLVEKQFHANNPRSKAPSDSIFTSDDDNDGGEEEDEIAEYQSDNRLLNTPKRRRQVHRMKSSRTLPRLNIYGEGNGALLASPSVPDYSTRAFTTPRKLRGGVQKRWKRREQIQRRKSVNQTYIESAVLESSSSQRNNQQQNFLHRNGASAIELPRLDNNGVKKIIPKRLYSVAAGGDGQFKYEKDKKNSNNIFGSILSMRTRGKKTKENRSLGNIYPGYNNSSSTTNPSPSQVYPYKADVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZA4</accession>
    <name>A0A914YZA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5428.t1">
        <property type="protein sequence ID" value="PSU_v2.g5428.t1"/>
        <property type="gene ID" value="PSU_v2.g5428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218071" evidence="1">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5428.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21192" checksum="7618680F3CC1DA89" modified="2023-02-22" version="1">MYSIIATIFLFFLNFGYSCRVLKPNDYFDIKLTINTSDCSFAGTDALLLLYLPFHGNQSYTFIPNLGPFQIQTDYNGLEGGETTTQTITWDEIKRSAKEKALCWPSLETVLIEKQRFNWLIPEIASAWKPKSIQITLNGTQTTEILREFPPNCDVGWINDNGFYQIGPAHDQIQMLSNQKEEVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZK3</accession>
    <name>A0A914YZK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5371.t1">
        <property type="protein sequence ID" value="PSU_v2.g5371.t1"/>
        <property type="gene ID" value="PSU_v2.g5371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5371.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18986" checksum="0077E6D90E15D713" modified="2023-02-22" version="1">MQVFESNHSLEWEPLDLFLSHHSPKSKVAIRSSGTNPEKVFIHGTCNVSGCTEQVHLYELDFSVLDQNNIEYTQIFTERSIDTPIPIPITSTPTIAVKKTPTLVEYINVARDMFAKNKAPSTKPKIILRKEKGYSNASSMGSGSDLRMSTPSLHSCLTNLSGSSDASNRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZN5</accession>
    <name>A0A914YZN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5399.t1">
        <property type="protein sequence ID" value="PSU_v2.g5399.t1"/>
        <property type="gene ID" value="PSU_v2.g5399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000158">
        <property type="entry name" value="dnaJ homolog subfamily C member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5399.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="29045" checksum="82745F91637EC872" modified="2023-02-22" version="1">MSEFDAFYSDLKTTEAQDATLTPSQQIERLLRPGATFLNLNPFEVLQVDPDTDIDAIKKKYKKMSLLIHPDRNLDDSERAKRAFEIVKKAMETLEDPDEVARCREMYEEARARLAIVMSEKKRKLRKDGQSDKIPEDEPQGYGKALWATVTKVFADREKKRKMLEERTMEEKRKFAEEIQAAQEKRKLEEEFKKNYEETRDVRSSSWRTFVQKKTKRLEPFRGANFKPPAQKLETSSAKKPKLDKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z072</accession>
    <name>A0A914Z072_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sec20</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z072"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3679.t1">
        <property type="protein sequence ID" value="PSU_v2.g3679.t1"/>
        <property type="gene ID" value="PSU_v2.g3679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3679.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19639" checksum="59F2C37F0C2DB8CC" modified="2023-02-22" version="1">MNCRCPELQEPIKNMAYRRLKEKQLNDEKEKRKELFSMQNQSVFEERQKQRQRDTLRGNVMKATESLGSLVSKMGEQVQRSEATTTTLIQSSDVLKTTHGQYDNINATIKTGSKIISKYGRREFTDRILIGLALFVYFGVIFYILRKRLPLMTYLFPNFIRYFFGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0T1</accession>
    <name>A0A914Z0T1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0T1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3878.t1">
        <property type="protein sequence ID" value="PSU_v2.g3878.t1"/>
        <property type="gene ID" value="PSU_v2.g3878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581:SF3">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581">
        <property type="entry name" value="PROTEIN CBG10435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="137"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3878.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31796" checksum="7C3B36CB735F6A03" modified="2023-02-22" version="1">MVSGKIIERNAAGDKFWIANENLVALTGEEPAAGLVYNRLLPLFSSHYKQAIEMAKEKSDEKKPEEKEKEHIHEHGHGHSHNHGHGHGHEHGHGHGGHGDNHGEAFPLMELLSKTTYRKHLIPDFLPLTGLREKLEKGGMEILDVGCGTGFHICEFGMAREFPKCSFTGIDISSNAIKRAQEVVKEMNLNNAINEINRVLNNDGRYTMLEMNKPGNPNDYGTTPMSMFWAVAGLFIVLPVRRAPEVFKWTNAAAVKMLKESGFKNVEPVKTPFYDFNILFVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0W7</accession>
    <name>A0A914Z0W7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7808 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0W7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6001.t1">
        <property type="protein sequence ID" value="PSU_v2.g6001.t1"/>
        <property type="gene ID" value="PSU_v2.g6001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056710">
        <property type="entry name" value="DUF7808"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493">
        <property type="entry name" value="PROTEIN CBG13422-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25096">
        <property type="entry name" value="DUF7808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037687635" description="DUF7808 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7808" evidence="2">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6001.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19336" checksum="4EB0BA74C70612F3" modified="2023-02-22" version="1">MNKTICLLFSVCFISVAVAESVHWQWRDLVCKTKEGKGNDKISEKPAECNIALRETEKDSNMRPSPSVNGGCFDEVVNGTTRTYCDLLCPKADTVYLIKRTPQVHRSCFVFFTHRLERRGDDWFLWRDKNCRLSEITFTIRCEFMFPRAEFPNDKELFHRLAKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0X6</accession>
    <name>A0A914Z0X6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0X6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6375.t1">
        <property type="protein sequence ID" value="PSU_v2.g6375.t1"/>
        <property type="gene ID" value="PSU_v2.g6375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6375.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14649" checksum="D493FDC8060472D8" modified="2023-02-22" version="1">MTIKIEGVLVVEKEMPKKGETFGDNRDALGLGLWNQEENKDITITADGKEVTAHKLVLAARSPVFAAMFESGMKETKENKVEIKDFSHDLVAAAIKLCYHHSLVTDITLNNKMALLQFFDKYDIQPLKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z114</accession>
    <name>A0A914Z114_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z114"/>
    <dbReference type="WBParaSite" id="PSU_v2.g605.t1">
        <property type="protein sequence ID" value="PSU_v2.g605.t1"/>
        <property type="gene ID" value="PSU_v2.g605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="10">
        <location>
            <begin position="173"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g605.t1"/>
        </source>
    </evidence>
    <sequence length="366" mass="37882" checksum="1210D6C370889CD7" modified="2023-02-22" version="1">MTLFGSTATPADASKTGGFNFGSNTGTTSTPLFGLAATSNASTVPAPSAGLTTGTPLSAAPKIGFGASTPLFGAAPTSASATPASSGLTFGTPLTAGSTTPAVSFGLGGTSTSSTTAAPSLGLTTGTPISAPKVNLGLNTTSSLTSGIGATPASTGLTFGGTSATSSTTTVPTSQAATQSMSFADFNGILARLTDEFEDLNRQFVEDVGFLNDFDKVLRDNHSKIDAANEELSEIENDTSRCANESECISAQLKDIANLVSSLEKQLNINELDNAIVSKNSDVKRQHIMQMYLATDAQMIQLEDDVEGLNQQVDAIAKVTGPDQTNTPETFDDIRQILGNQMDQLIYVDKQSEELNKRLIDIKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1T0</accession>
    <name>A0A914Z1T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1T0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5856.t1">
        <property type="protein sequence ID" value="PSU_v2.g5856.t1"/>
        <property type="gene ID" value="PSU_v2.g5856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004511">
        <property type="term" value="F:tyrosine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006585">
        <property type="term" value="P:dopamine biosynthetic process from tyrosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF15">
        <property type="entry name" value="TYROSINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="7">
        <location>
            <begin position="151"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5856.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24269" checksum="B9C58CB71161E5AA" modified="2023-02-22" version="1">MPAGYGGRRNSLIWQASIEKGQNEGLRRQNTIKKRTELSRQVSFKEVIEKLNDSGLELIQTSDDSTLLKLDLIINSTSDSIKVLVHMIQKLNSVGIALKHVETRPDKAHPGELEILAQIETRKPLLMEVLDHLIADKIDRIEIKSSEKDNTITSSKNVASEENIWIPTHVSDLDKCGHVVVKYEPTEDPKHPGFGDESYITRRAELNSIANNWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2G7</accession>
    <name>A0A914Z2G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2G7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g655.t1">
        <property type="protein sequence ID" value="PSU_v2.g655.t1"/>
        <property type="gene ID" value="PSU_v2.g655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g655.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13426" checksum="09972DF99C3DD9B3" modified="2023-02-22" version="1">MIKTLNKNYNNQILLESPKTTLNFFLDTLPCKLSYYNLRKAIETTTSKSSEEFVTFISAEKIAEFERLNKILSVIAILAIISQRNHAWKQWIRNSLVCFSIEELQIRYSYAGIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3D7</accession>
    <name>A0A914Z3D7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3D7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6406.t1">
        <property type="protein sequence ID" value="PSU_v2.g6406.t1"/>
        <property type="gene ID" value="PSU_v2.g6406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF51">
        <property type="entry name" value="ANOCTAMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="8">
        <location>
            <begin position="235"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6406.t1"/>
        </source>
    </evidence>
    <sequence length="604" mass="69884" checksum="7DEBC730CD160DB0" modified="2023-02-22" version="1">MEDDDNNDFSAHVMLQQKLGCIIQDGITEGQRFALSSDLWRCASASPHCDVLITLRPQQNKQILKELVLWLHDIIKKSEPHFDIKIKHHNLTNSYGLYITANYTSLLKGAELCHLKKPIKPSYGGGMRDFTIDEAKCFQGLEIRSNFLSGMERSMIVRQMLQMIKAPSPGGFLFRPISTESPHQVLVPDGGTLLVSLMSQNVIENMLPLHQPEILADLQKRWVFALFDEQPLEDIKEYFGTEIAMYFAWLGHLTTALWTPAIIGVLMFFIGGFSFVHKDNQEENTLFGDICFVIFALINCIWSTAYLEMWKRQQAELAFKWGTYELQTDQFLEDPRPAYKGECLKPNPVSGRLEPFYPPWKHMLIRYGVTFPLTLLCVSFLFFIMFCLLQLQDMADAVFKHSYYFKWIIYLPMIVYALIIVSGDFFYRRLAIILNDLENYRTDDEYENYLIQKIVMFQCVSAFGSLFYIAFYLNDMRRLQETLATLLITRQLTQNIIEIAVPFIIEKFKVARLTYQMTRSMSDHSLQRHVDAARKRRDTFQSTPSSELDETISHQDNADEEEVCESEEGRELRFRKPNGSSLLSVTSSPKRLSSNSEGLCNFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3V2</accession>
    <name>A0A914Z3V2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3V2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6570.t1">
        <property type="protein sequence ID" value="PSU_v2.g6570.t1"/>
        <property type="gene ID" value="PSU_v2.g6570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6570.t1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41419" checksum="B8EB9D1AA53FCAB4" modified="2023-02-22" version="1">MIDNLDPAITDITSELELLSMYVPIPNVTAPTFPTPVTVAPPQVTVNFVPPAENKRRLFSGNPADYKSFIDEHDASVGSQTMANVLKLQKLKERCDGEAYDAIKKFNTDAGYQEALAKLKQRFGSDAQAIAALRKQLYVPVKDKTDLLAVRKSFDDFECCLSKLDEYNQDIDSIEFKLALLRKLPDIIISKLSDFEMNGNQFVASGKYKLNIHLEDGTTLPVYPYGAANLVQRISVPKVPVEKYLRATNGKFPLPIKLGLPLLLLSMREYALLFIDEESKKLDNGFVLWQSKLGPFISGEGKVQRECIRSQSPLVSSITVENNLESNDTQVNLSSGNLRDITAIETEQDKGCFSTQKVDDSLSYNPACKSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z443</accession>
    <name>A0A914Z443_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z443"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5027.t1">
        <property type="protein sequence ID" value="PSU_v2.g5027.t1"/>
        <property type="gene ID" value="PSU_v2.g5027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5027.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="54308" checksum="683C7C9420A7480D" modified="2023-02-22" version="1">MSIFRPKWKSRDPKGFPILIWIHGGSWMMGSTEQYGYKRVSDNFIPQGIIIVSIQYRLGPWGFFSSGDSRMPGNLGLWDQYTAIKQVNKFAPFFGGDKNRITVMGQSAGSASVSWLSVAERAHKLFQQTIEISGSVFGVWARSDETIETSLKLAASLDCPDTKDLKKCMKNLTQEDIQDQMLGMGIFKQNLNFAFFNPRMDGDFLKAKSFEEAIKKAPKRPTLIGNTNKESLFWSAEQLGLVPADEIYNRADDEIEEYSREKLEDFIRKCVATKERYGSRAAEAGDEIISHFADSKAPKKPDNLFYFDRFTDLLSSIHFETPQIREALNKAAAGYPTFYEVFSYQKSKEITEYKIDGAPHGAELDALFHSFVYAGFEETKDDPKIQKIMAEIFSAFIRTGNPSTETLTIPPVTSKVIPYVDINLEPKIKQNPFFHNYLFWERMTKKYGYDVSTGTKVTKFSKPIRRRRVQRQVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4E8</accession>
    <name>A0A914Z4E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4E8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6768.t1">
        <property type="protein sequence ID" value="PSU_v2.g6768.t1"/>
        <property type="gene ID" value="PSU_v2.g6768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6768.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28528" checksum="319847537BD4AEFC" modified="2023-02-22" version="1">MAPETLKRNPEYSSKSDVWAFGILAWEVFSYGEKPWPDWENKKIATYIRRGKMMDLPEYTPTQIKNLVAKMWIVKASERPDFSEILKTIIEIQLVFPPPKPQSCTITHIKGVVIHVTPEVEDQDSEDIQITAAAFSAKTPSAELPPSTPGNVGHSTAEEQEQLPKKKKKKHRTGCCLLDYILNKGKNKSYEEIPPPVASSPAEHTKKKKSNKQAISSEARSLDTCTDGTGNVEWDKTDLSTEQKHNGLKRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z535</accession>
    <name>A0A914Z535_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein UBASH3A-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z535"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7009.t1">
        <property type="protein sequence ID" value="PSU_v2.g7009.t1"/>
        <property type="gene ID" value="PSU_v2.g7009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF5">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7009.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30699" checksum="420E984DE6C1C2DD" modified="2023-02-22" version="1">MRHGERLDDLFGEWYSYCKNKNGKYRQRDLNMPPDLSPLNRPLGEYQNDTALTVLGHVLAQMVGRAMLVSGRSPDMVYCSPALRCIQTASVAATMTGRPFKLRIEPGLFENFDLYPDKKPKFVTVEELKHSGFNIDDDYTPYCKMEDLFAVSESNEMYNDRVQSSLQYIANKSAPGRGTVLVAAHASTVDLAFGKFHSRFLKEPRQTTPENLMNISIPVPYSSNVTFMRNSDDDQWQYIREALPPITYRNFSNRLNHDFIERCNAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5G8</accession>
    <name>A0A914Z5G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MYND-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5G8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7206.t1">
        <property type="protein sequence ID" value="PSU_v2.g7206.t1"/>
        <property type="gene ID" value="PSU_v2.g7206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7206.t1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44681" checksum="2BDB65420A1056A7" modified="2023-02-22" version="1">MAAKKPVVYMGFGKELDAANIVTLKRHYLPLGKIGGKPAWLNPIKLPSVDLIGCKQCNKVMPMLLQIYCSGESTNSFHRYLYVFMCPNNACQKICSSDNFRVLRCQLPRHNDFYGSEKLLNFEQDGEIDDPFFDAEKYAKLCNVCGALGTKMCARCRCTWYCTKDHQVIDWKEGHKQSCQEGKVIPKSEDKDRFCAEKENSFIYEELGMELDLEEEREDTSSDDEDDDEIEDEIMRQELLSKANNLMQKFDPKNEMNDLNECEESEKDEKYLKFSKVVKRNCYQILRYNRGGEPLLATDHAKAPSGIPLCGSCGSKRQYEFQLMPYLLSLIDIDDVSSKVDYATVLIYTCSKDCDIKDFGYSEEFAFKQDFIFTGKEEGNYVDENDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5X1</accession>
    <name>A0A914Z5X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5X1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8080.t1">
        <property type="protein sequence ID" value="PSU_v2.g8080.t1"/>
        <property type="gene ID" value="PSU_v2.g8080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8080.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27229" checksum="AEA1FBA8EEC80AD6" modified="2023-02-22" version="1">MRSFPLVVNGAYAIFYAYTLYFDYGRTEEFQNLFPIPGNFWSKYVWLTMINLTIQFLYHCAGTYFAITSKTNTQNTTPQNVFHFISTTIAFPLSVTVVTLFWGLIYLDPDFVLTDEAKLMLSITWYNHALHTVPLIAMIVDFIAWRHPQPRIYPALKATVAFIMFYLTDVHLVFFYTGKWAYPILDQLDLPKLIGFYIICIGVFFFNFLMGYGLNQMIGPIQRPVPKPRKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6E8</accession>
    <name>A0A914Z6E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g7480.t1"/>
        <property type="gene ID" value="PSU_v2.g7480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7480.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15192" checksum="8ADF41F335A1AD23" modified="2023-02-22" version="1">MVVPEGAAGVDRSINPETALGHMDESPYEGGKEASAEGVKPAKKERENFHVNNEAEAVQIEAIEDDPLEPPMQNRRYSKEFEQKILNIKEPEPEPPEGTDPAVINDPTPDAPGAVKEPENSPNVSDLTLIKPETEGKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6X2</accession>
    <name>A0A914Z6X2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
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    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g7656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037800748" evidence="1">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7656.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17136" checksum="213611C5D2200609" modified="2023-02-22" version="1">MNFLLITFFVAAILSFVICDPEYTSFEPADYVFHGRIRCGARRAPILSSAYARLMEFDPISAHDDVQTSRIGKDGNFTVRALKHMTDPPTHQWELFLQFHHPCDFGNGYDQGAIYASGFVKADLSLTGYETVYTIEDKDFFCSKCVSVYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8M6</accession>
    <name>A0A914Z8M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8M6"/>
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        <property type="protein sequence ID" value="PSU_v2.g6600.t1"/>
        <property type="gene ID" value="PSU_v2.g6600"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39387">
        <property type="entry name" value="SHAVENOID, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39387:SF1">
        <property type="entry name" value="SHAVENOID, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6600.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23612" checksum="1EE3AFD8F9C43380" modified="2023-02-22" version="1">MRILYQMKQDKDKEVLENNNKNHRYQSIARNNQDKNNLQSNEEIIDETKGGEMVQHGIVKRKLFFSAEFFEPHFMMNPPPMAEQFLYDLRKMIDLAKHRIHGKKHIPQLVSIPEETKEHYEPYMELQNRSQNLQVTTPTIYSTREEENSPKSVKSCDSGRESMRDASSTESVASSTDLNGPKARSPIPSLPKWWCKKSCKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8V5</accession>
    <name>A0A914Z8V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6677.t1">
        <property type="protein sequence ID" value="PSU_v2.g6677.t1"/>
        <property type="gene ID" value="PSU_v2.g6677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6677.t1"/>
        </source>
    </evidence>
    <sequence length="536" mass="58986" checksum="3F2382DA2892F160" modified="2023-02-22" version="1">MGRIAEHPLSPRSSSSNNKISVDHYSDQAGSSDTTLKPRYYLSNNAVLPGTTSSLATTSPQTVSTSATDLGTSAECCSCAFRAVKVGHFNCLKNMSKTLLTQVDVEQRSMLHLAVKHGNISIIDYLLHEAPQLADFESNLKETPLLIAAATGRLDIVEKLLRGTLRICLQRALHRDINGTSCLMAAIARSDNDTALWLLRRFGRQLAMLPNNCQMLPIHAASANGNLEFIRIVTKYDPRMVNFKDQFGLSPCAYACQNGSLQCLRYLIEKANADISSLTTKGQSLLHISSLSGHVPIVRWLIYRTGSDAILWPTYDRANAIHCAAFGGQINVVKILLDLWPKKRRKAILTTTDSRGNTPLHLAVISNQLEMVKYLLEIGSNFKLLNTTGQTAEQIAQVRGYTAVAQSIALYSHGKKLKKGKKFSRSCTDLVQAGTTSPTIYSSNKDYSNAYTDTTLPGHGRNDTFDSSSGFLSGGEEFLEIDLPKKAEMSTQTDPSHFEAESKVINTEEWHGETLAAVEEIESMFKFLKVLDTRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z939</accession>
    <name>A0A914Z939_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z939"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8434.t1">
        <property type="protein sequence ID" value="PSU_v2.g8434.t1"/>
        <property type="gene ID" value="PSU_v2.g8434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8434.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8778" checksum="683B55539186147E" modified="2023-02-22" version="1">MPNKREFCEEHGKYVSSPVFRNHNGRRLCNAREAGGRYEDGGEAGGQYEDGGENEGGEDVAYDPEGSDVDVAPEVDLDDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9E4</accession>
    <name>A0A914Z9E4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9E4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9295.t1">
        <property type="protein sequence ID" value="PSU_v2.g9295.t1"/>
        <property type="gene ID" value="PSU_v2.g9295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9295.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9022" checksum="68BFEB1513834EB8" modified="2023-02-22" version="1">MMNTVTLNLVGGPPWGFRIAQEDNEPPFVSQVLLEGRAYNEGMRVGDYIDGINGEDCAFADQVHQKMRTTKGVLRLRLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9H2</accession>
    <name>A0A914Z9H2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9H2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8456.t1">
        <property type="protein sequence ID" value="PSU_v2.g8456.t1"/>
        <property type="gene ID" value="PSU_v2.g8456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8456.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9100" checksum="3CDB11DDB70FA9B5" modified="2023-02-22" version="1">MTDPVVIADILNRCLDIAVNYKGGVFQADCDFTTLETLLADSTIKLDLFCFGISIIVKSDSEGFAVSSNGEFVGDLYLANELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA42</accession>
    <name>A0A914ZA42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Macrophage-expressed gene 1 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8793.t1">
        <property type="protein sequence ID" value="PSU_v2.g8793.t1"/>
        <property type="gene ID" value="PSU_v2.g8793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8793.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32675" checksum="8E5F4FECB8C00E76" modified="2023-02-22" version="1">MQQLKEIADAVEEDDMLLAQYEAENLIAIYGTHVTNKALAGASITMLSFTKVDDSHTSVSIKANLSASFKANFLGIVKGEAHLKAHFGLDFDSTTHDESSQSYIITKGGADVNRLLDKNDDGNKLHVDSVVGIKFNSVPLYTLVHENSVKSHKNTTMKIVQELITDATQEYFRHNTIPGCMNPEMPNYFYKANVDDNSCQMEFRWPTFGGIFQKCQFLGSYLAGNGDKNNFTSIDYCKQYELKNPYTKDYTCTFGFDATEIDSFYVTVKNRTHSVQFSTCSNSSSVIFVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC28</accession>
    <name>A0A914ZC28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g9876.t1">
        <property type="protein sequence ID" value="PSU_v2.g9876.t1"/>
        <property type="gene ID" value="PSU_v2.g9876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56954">
        <property type="entry name" value="Outer membrane efflux proteins (OEP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9876.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18019" checksum="DB8461685D7C942B" modified="2023-02-22" version="1">MSNPELGARFQDFQSALEGQNVPLCALLPEVNAQGWVGKEWRGSTSGAPSTDWSRSGYSLQLHSLALEXANAHIDVLRYREMEKLARETRHAHEHPEPDQERSGIPGRRGPWVVDLEQAMDRQSLAQSNMMTEAGNLRTTCCNATVALWVWGLLPEVMQSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCB5</accession>
    <name>A0A914ZCB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZCB5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9967.t1">
        <property type="protein sequence ID" value="PSU_v2.g9967.t1"/>
        <property type="gene ID" value="PSU_v2.g9967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="51"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9967.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="37837" checksum="B39A9371B5A7FFA8" modified="2023-02-22" version="1">MNLQKQQQEILNVPLKSRSDSISTSTSIDSNDSVETKIENGFYCWNSTRYLILIISLICFSLTWGNALAYNFTIICIENNFTEPKSAEVWKNESDKNDNLKNDKTYVFSQNQQNLLLSAVAVGSIIGSVILPYATSKLGIRIVFTIYGFISAISTLLCPFAVSHGFPMFYIMRIGQGIANSIGIPGLGAVTTPWSPISSSGIFLSLLSTHLQFGPIFTMPLAGQFCASSFGWQGIFYLQGGLTVIAFIAFFAIFNDSPKFHRNVSSKELSIINHGKLTNGISKGLKIPYLKIFTDKSVIGVVIVSLGAGIGFQVLNQYGPVYLFKVLNFDIKHTGSAAAIPFIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGT4</accession>
    <name>A0A914ZGT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZGT4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9496.t1">
        <property type="protein sequence ID" value="PSU_v2.g9496.t1"/>
        <property type="gene ID" value="PSU_v2.g9496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="287"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9496.t1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43262" checksum="81B171CD518F074C" modified="2023-02-22" version="1">MNRLTVGMHVDIKRSDGRVHGAVITDIKEDAKTVNVEWFEKGETKGKEVDYLNLIKQNPTLDPSLLSNPFLSSKENDVVVVTKRPSPTIEKNGSLHTTPAITPTSSEDPILPAIRPSNGVGLGTNRKSVIVESKPATAASPVAATRKAVLPHPKARVLPLRPRPSEAFDPDATFIAPLPPPNRETPKIEEPPTFIAPAPVTNAPTNMVNMTLTNATAKSSCVNEVEKLAHKREERRQQQADAKRQINERKSIDPGNPNWQFLCMIRDYRSQVDYRPLQFNDGVIDNRICVCVRKRPLSRPEIQRKEIEVLTIPNKDHLVVHQPQQKVDLTKYLENQKFRFDYTFDENTNNEMVYKFTAQPLVKTIFQKGFATCFAYGQTGSGWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGY6</accession>
    <name>A0A914ZGY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9550.t1">
        <property type="protein sequence ID" value="PSU_v2.g9550.t1"/>
        <property type="gene ID" value="PSU_v2.g9550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9550.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20251" checksum="BF7E5D4EFA12EA9B" modified="2023-02-22" version="1">MGGHLASIHDGFTNALLTGHSVNIFQGAKDYWIGLSNINTPKKLSWMDGTKLDFVDWDKNQPGKISGIRCTSAELKTGLWKTDSCFLQKSYVCGVPKAAGGSTTMPPMTRTTTRRTSPTTTGSGAGCSGNFTYFAPTNACYGVFNTYDPDATSWNASEALCQSINGHLASIHSADEFTFIMSKYKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSU9</accession>
    <name>A0A914XSU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Laminin G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XSU9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10038.t1">
        <property type="protein sequence ID" value="PSU_v2.g10038.t1"/>
        <property type="gene ID" value="PSU_v2.g10038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10038.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10720" checksum="B6ABFA51963A1F4D" modified="2023-02-22" version="1">MERPVHSIRVEQVRVDDGKWHKFVLFQAWENVKIQLDNTVLFKILTQRSFVFGNLRTNSDVFVGGLPTVRTFKNLAKCHPPFDGIQKDLRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTW7</accession>
    <name>A0A914XTW7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8 9">Cytoplasmic vesicle</location>
            <location evidence="8 9">COPI-coated vesicle membrane</location>
            <topology evidence="8 9">Peripheral membrane protein</topology>
            <orientation evidence="8 9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8 9">Golgi apparatus membrane</location>
            <topology evidence="8 9">Peripheral membrane protein</topology>
            <orientation evidence="8 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTW7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10414.t1">
        <property type="protein sequence ID" value="PSU_v2.g10414.t1"/>
        <property type="gene ID" value="PSU_v2.g10414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="11">
        <location>
            <begin position="123"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10414.t1"/>
        </source>
    </evidence>
    <sequence length="362" mass="39350" checksum="366F6A0C45BB6D5D" modified="2023-02-22" version="1">MRDAISKGQQRAKELKKNQERTMGKGGRGISSATAISSSNSHNFASADAALNSSSTSSYVPKTPAVSAAASSKGGGKALKLGANKTVSEDAFLQQLRSEGQLVADLQKSSIADKGKPVIHEDRSPVYVQAIEKLNASVSRNGGIESAEILGNVSLNLTESEFNTVTLKMKCKQVVGTQIQIHPNLDKQVWQKESRLQLKSIQKPYPLNTDVGLVKWRNVLNEEEQLPLTLNVFPSESADGCTVNIEYTLQKEIQLSEVVITIPLPPATQPIVSEVYGSYDYVRSKSQLLWTIPIIDSSSESGTLEFSVPNGHSDHFFPVNITFTSENLICGIEVEDVINHDGSDSVEHTLHSGIVVDKYEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU87</accession>
    <name>A0A914XU87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Clc family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XU87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10811.t1">
        <property type="protein sequence ID" value="PSU_v2.g10811.t1"/>
        <property type="gene ID" value="PSU_v2.g10811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000042">
        <property type="entry name" value="Clc-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF54">
        <property type="entry name" value="CLC-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10811.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29591" checksum="077EE577ECDA5D46" modified="2023-02-22" version="1">MAVEYEWSLQTPAFVVAIIGWITSFVALLTPAWQTVYARELQQWIQSGLWLSCQTRPSGMYTCTYTFNEADFNFYTSAEIVDWRTPPFYAWQRRLLAVYLGAQLSAFVALISFCFALQPNGRRISSLTFVVAIAVATILHAGTTVVFMFFSQLVEYRFYHVSVSGIYEKHRGYSFFIQVAAVILFLISLIIAVIHIFTTSRLRNDNAGSIKYADSFVNAGPYRQVESYFPRPGSSSSELYPYESQFAMRELPPLPKGSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUF0</accession>
    <name>A0A914XUF0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Malate synthase</fullName>
            <ecNumber evidence="2 3">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XUF0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10871.t1">
        <property type="protein sequence ID" value="PSU_v2.g10871.t1"/>
        <property type="gene ID" value="PSU_v2.g10871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="4">
        <location>
            <begin position="89"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10871.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29582" checksum="1A10FE638898CE82" modified="2023-02-22" version="1">MNWSGSSIPDDMKDRRVEITGPTDRKMVINALNSGAKVFMADFEDSNSPTWRNQLEGQINLYDAVRGNISYIHPTTKKEYTVKENSAVLNVRPRGWHLPEKHVHINGEPMSGSLFDFGLYAFHNSRALLDKGSGAYFYLPKLQNAEEAKLWADVIKFTEQKLEIPKGSIKCTVLIEHLLAAFEMDEIVYALKDNIIGLNCGRWDYIFSYIKTFREHRKFLLPDRFQYAINEIFLPWVEWLHKFLLNMMNVPMSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUP8</accession>
    <name>A0A914XUP8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914XUP8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10972.t1">
        <property type="protein sequence ID" value="PSU_v2.g10972.t1"/>
        <property type="gene ID" value="PSU_v2.g10972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1270.20:FF:000001">
        <property type="entry name" value="tRNA (guanine-N(1)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000001">
        <property type="entry name" value="tRNA (guanine-N(1)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="entry name" value="tRNA(m1g37)methyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_TrmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000648">
        <property type="entry name" value="PRK00026.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417:SF1">
        <property type="entry name" value="TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA methyltransferase TRMD/TRM10-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10972.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27893" checksum="5460A0F5ED7A2F6D" modified="2023-02-22" version="1">MRFDALTLFPDMFDVVSEAGVTGRAHKQGIWQMRTWNPRDYTTDVHRTVDDRPYGGGPGMVMLADPLNDALDQALADRGDSPEVILLSPTGRRFDQAVAQELAQGPGAVLVCGRYEGIDQRFIDARVTQELSLGDFVLSGGEIASLAIIDSVIRLLPGVLNDADSARQDSFHADNSGLLDSPHYTRPEVYRDQAVPDVLMSGHHGRIQAWRREQSLRLTALRRPELIEQARQRGELSKADERFLASLASLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVD1</accession>
    <name>A0A914XVD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVD1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10496.t1">
        <property type="protein sequence ID" value="PSU_v2.g10496.t1"/>
        <property type="gene ID" value="PSU_v2.g10496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000842">
        <property type="entry name" value="Nuclear receptor-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000607">
        <property type="entry name" value="Nuclear receptor-binding protein 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10496.t1"/>
        </source>
    </evidence>
    <sequence length="710" mass="78601" checksum="C1C2BBFEF0EF0F48" modified="2023-02-22" version="1">MTGDDGGSADDKPPTTGNNNSNFNGIQQQQQHQSQSQQPSLSTTTTFNSQSHPSTTLTTDSSRGSISSQSSNISPSSGAKKTVFFSKPETDSGVALPAETAAEAEAVLQAIAADEKNGDKSESDNEQDDEIVEEGRDGRWSKRKDRVKQRDVPGIDGSFLAMDNETGNEVVWNEVQFSERKNFRNQEEKIRTVFDNLMQLDHVNLVKFHDWWADTKPEKPRIIFVTEYMSSGSMSKFLQRAKTSETLSNIRMWKKWTIQILSALNYLHSCDPPIAHANLSCNTIFIQQNGLIKIGCVAPNAIHHHVKTFRENIRNLHYIAPEYEYLNEVTPQADIYSFGICALEMATRGNMPSSSSGTNGTETSSNHMSHEILMKAIDSLENPLQRDFILKCIDSDPKNRPTAKELLFHPVLFEVHSLKLLAAHVIVNSKMIDHLSEDDLRIRDSSHTAFEFRGHIYTYADMEAFHCCKMDLDKFLEDVKNGIYPLIAFAPLAHRPLKLLSQSPSAIILPSPKMSEDPSMQPSASAPQNIGNQILHGHHHQHPSSMASNGNRKNSADDILGGSSNAFETNGNYHRNENDPNSGKATTSDSHSQQLNLPNSSTNNLPPYIDTSSATSTITSMTGSLGSPTALEPSSTISSQGATSSNGGDKPQGENRLIRHMRAAIKDQILNMLLQLDDYMNRQLTTEVNENDHADELVIELINHGFICQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVP2</accession>
    <name>A0A914XVP2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A914XVP2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11301.t1">
        <property type="protein sequence ID" value="PSU_v2.g11301.t1"/>
        <property type="gene ID" value="PSU_v2.g11301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000117">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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        <property type="entry name" value="ATPase_P-type_domA"/>
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    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
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    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
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    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
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    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
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    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
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    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
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    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
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        <property type="entry name" value="Cation_ATPase"/>
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        <property type="entry name" value="E1-E2_ATPase"/>
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        <property type="entry name" value="PhoLip_ATPase_C"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
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    <dbReference type="SFLD" id="SFLDG00002">
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    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
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    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="219"/>
            <end position="238"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="758"/>
            <end position="778"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="808"/>
            <end position="828"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="862"/>
            <end position="882"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
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            <begin position="53"/>
            <end position="194"/>
        </location>
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            <begin position="696"/>
            <end position="923"/>
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    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="304"/>
        </location>
    </feature>
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        <location>
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        <ligand>
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    <sequence length="930" mass="104313" checksum="24F11D7F7664E322" modified="2023-02-22" version="1">MACSQFIPAIQIGAPITYWGPLGFVLTITLIREAVDDIVRFWRDREMNGEKYEKLTRNGFDEIESADIQVGDLIVIHKDKRIPADVVLFRTTEKSGACFIRTDQLDGETDWKLRIAVPYTQNMPEDSDILDLNCEVYAEKPQKDIHAFVGTYRINTVEGVTDGGLSVENVLWSNTVLASGTAIGLVVYTGRETRSVMNTTLPESKVGLLDLEVNNLTKILFLFVVVLSSVMVIMKGLDANWYRYLMRFVLLFSYIIPISLRVNLDMAKLFFSWLIGRDKNIPDTVVRSSTIPEELGRISYLLSDKTGTLTKNEMIFKKIHLGSVSFSGEFNDVAMHIESAYSGKLGRHSFSVKLQTAVEAIALCHNVTPIEENGKVDYQAASPDEVALVEWTEQIGVRLAFRDLAAIELQLNNGNRKRFQILHMFPFTSESKRMGIILRDELTDEVSFLMKGADTVMAPMVQYNDWLEEECSNMAREGLRTLVVAKKTLSAEQLADFEKQYHAAKMTVTDRSEHMAAVLRRLETDLQLLCLTGVEDRLQDQVTTTLELLRNAGIKVWMLTGDKLETAICIAKSSGLFSRADNIHVFGQVQSRTEAHNELNQLRKKSDVALVMTGAALNVCLQYYEAEVAELVCACSAVVCCRCSPEQKAQIVNLLKRYKKPARVAAVGDGGNDVSMIQAAHAGIGIDANEGKQASLAADFSITQFHHISRLLLVHGRFCYKRSCALSQFVMHRGLIISIMQAIFSCVFYFASVSLYQGVLMVAYSTAYTMLPVFSLVVDRDVTADNALTYPELYKELGKGRSLSFKTFCIWVLVSVYQGAVIMYGALLAFDYDFIHVVSISFSALIVTELIMVAMTVHTWHWAMLIAQGLSLSLYAASLLILDKFFDRQFVLSWTFITKTTLITIISCLPLYLFKLARRRFSPPSYAKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVR0</accession>
    <name>A0A914XVR0_9BILA</name>
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        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVR0"/>
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        <property type="protein sequence ID" value="PSU_v2.g1106.t1"/>
        <property type="gene ID" value="PSU_v2.g1106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="82"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1106.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26048" checksum="05086B5C5AAA67A9" modified="2023-02-22" version="1">MTQPPVSIAVDLDSLEKEIANREQERREHNYRDLSGNIGNVPARSASRTNSEPNGDGLDFDTLDEPKRDLKLVGEKFGQVLRPHENQKLLRDWDLWGPIFICVVLALMLQGNSKGPLFTEIFALTFFGSCVVTANIKLLDGGISFFQSVCVLGYCLLPLVVASLMCRLIAHGLPLNSISLGLKLLSAAFGFGWATYASMGFLAGSYPQKRRYLVIYPIFLFYFVISWLTLSYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXK7</accession>
    <name>A0A914XXK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1048.t1">
        <property type="protein sequence ID" value="PSU_v2.g1048.t1"/>
        <property type="gene ID" value="PSU_v2.g1048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1048.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27281" checksum="4123DBFFCD6D5EF7" modified="2023-02-22" version="1">MTPTLRQKVLNVLNLARNKLESGQLLLNNGEYAVQAASLPDLTWSCELEEEMFEKMEESCDSPLNADLQSLGLTWAFNRFDDSDAETLVDAMLENQPVLTGFYHVQLSRHNLYLEPISTFGTQIIALSDKAQYVACAIQNCNISAVSSGWALPGEIMNNIYCKVSLTEQLGFGDEIYQISPYIVNYIPPSQDVVCPSSGMVIEQREAVLEKINAARSQISQNNYHLPNGNNALPPAQPLSPLVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXN1</accession>
    <name>A0A914XXN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11712.t1">
        <property type="protein sequence ID" value="PSU_v2.g11712.t1"/>
        <property type="gene ID" value="PSU_v2.g11712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11712.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11223" checksum="3EEBBDA12E5C4363" modified="2023-02-22" version="1">MYGAICWLMSGYLIYFQSLMHVTIALNRTWIAFDMQKKDSGKFEQIANFGLYLLPLMPFAILSVRFAGTTVYRFDANGEIFGMYVETYVSNVSGCFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYU0</accession>
    <name>A0A914XYU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10850.t1">
        <property type="protein sequence ID" value="PSU_v2.g10850.t1"/>
        <property type="gene ID" value="PSU_v2.g10850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000698">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="393"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10850.t1"/>
        </source>
    </evidence>
    <sequence length="693" mass="79729" checksum="A7F915104BB117FB" modified="2023-02-22" version="1">MNTQMFQHLEKDLFNTGPQSAGTFPREKSNHSVDDVRIIDKMTEVSFGNGNQEDYNRLMDIAQQPNTSNETQNSDVNMVEVRVQTPVSRTKAYKGSPPEGIDAPPKAKRKRRARNVEVKDTQNVHSSPRRPLTLNGDSSSNEIPPYSPSRVITPNNHATSSSGFSPSQENGFRDVQIQTEHVVSTSNSHGDAEKNKSAEEARSLRKSLDETLRENDKLKNKNAKGQNIIRELLIEQMNNERKKIREIIQDNNRRIGYFKLSGEILRHGENWIDGCWKEEIDRRKAKLDAEKEDTASEAISLKKKKTVKELKKVSENDDEGFLKPELPQLTDLDRKDEILRARKEYIKREDAEIAAERERLERERNLHIREIKRVQHEDDSIFNKYTIQKNDRYVLLTLLGKGGFSEVWRAYDLDSYRSVACKIHRVNKQWNDNKKASYVKHAIREKDIHKTLDHPNIVKMYELLTIDQDTFCTVLEYCDGNDLDLYLKQHGCLSEKETRLVIGQVVDALRYLGDRTPPVIHYDLKPANILLQSGCRKFEVKITDFGLSKQVETSEDCDSIELTSQGAGTYWYLPPETFRDSSVKINTKVDVWSVGVICYQCIYGKRPFGHDQTQQRILNEGTILKATAVNFPIKPTVSQIAQDFIRKCLQYEPGNRADVFELSRHEFIKLASRRIVQQPASPSSRTARDDLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZP3</accession>
    <name>A0A914XZP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11112.t1">
        <property type="protein sequence ID" value="PSU_v2.g11112.t1"/>
        <property type="gene ID" value="PSU_v2.g11112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11112.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8459" checksum="AC7C60B3858F28F2" modified="2023-02-22" version="1">MGSECSKGFDDMNYSGQYSICTNKCQAVLQATSVKDVMYDILFIIAGFIVGYLYARFNSICKNAFKEHLASQQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0G9</accession>
    <name>A0A914Y0G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0G9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12961.t1">
        <property type="protein sequence ID" value="PSU_v2.g12961.t1"/>
        <property type="gene ID" value="PSU_v2.g12961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00438">
        <property type="entry name" value="cupin_RmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="RmlC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="DTDP-6-DEOXY-D-GLUCOSE-3,5 EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047:SF2">
        <property type="entry name" value="THYMIDINE DIPHOSPHO-4-KETO-RHAMNOSE 3,5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12961.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17245" checksum="3CC58EA12818CC8F" modified="2023-02-22" version="1">MSSIPSVIKRVKPEIESIPEIPDLKIIRPKAFPDDRGFFVESYNIEEWKELLNFNETFKQDNHSFSKYGVTRGLHTQPGMGKLVSVVSGKIFDVAVDIRKGSPTFGKWHGVVLDAESKTNFWIPDGFLHGFQVIILLSMFFMQRNQNYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0K5</accession>
    <name>A0A914Y0K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0K5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12743.t1">
        <property type="protein sequence ID" value="PSU_v2.g12743.t1"/>
        <property type="gene ID" value="PSU_v2.g12743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765954" evidence="1">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12743.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="6672" checksum="63D78FBD089332EF" modified="2023-02-22" version="1">MKLLYILLVCVALFGSSAAFGFGAMGGGGGGCGCAPPPPPPCGGGCGGGGGGGCGGGFPPPPPPCGGGGGGCGGGCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0R3</accession>
    <name>A0A914Y0R3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0R3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11442.t1">
        <property type="protein sequence ID" value="PSU_v2.g11442.t1"/>
        <property type="gene ID" value="PSU_v2.g11442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35014:SF1">
        <property type="entry name" value="INFECTION RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35014">
        <property type="entry name" value="INFECTION RESPONSE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11442.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31742" checksum="51F6037D09057549" modified="2023-02-22" version="1">MDDLNTTFKAFFNDKKVIAWFFDKTLRQMMSKISLSWLKALSTCMKCLILFAVLCGTTFAADCSADNVKTVQACYLSYFTRYGLKFMPDYNTYLATAQNFVNRNGLKGETTVQGWVKTRIACLQPYVPDCVTTDAMKLVFNTDNQTIAREWATTRPIEDWEFTDGFAEMTSNYDCLRTMHNQHQGDVTVCANNMTAGFQHGLSCQVTYDYINCMMNVYNKYCGKSAADFICHSTSISMNFNFPQCASGTPTCPGKTYKGIFGRLINMLNLRKNHPLGNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y112</accession>
    <name>A0A914Y112_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Golgi to ER traffic protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y112"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13139.t1">
        <property type="protein sequence ID" value="PSU_v2.g13139.t1"/>
        <property type="gene ID" value="PSU_v2.g13139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000060">
        <property type="entry name" value="Golgi to ER traffic protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13139.t1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44959" checksum="D813184D6A6E3FC4" modified="2023-02-22" version="1">MPKFDKLKQKIESALKEKNTYEALQIYRTIRNRCKDEEQALECLDLLSDGIQHFAKEKEETTLIDLAEVYADTLVSLHVTTSEKIYSQIETILSLLPSFLSKHDPTSPSNVDVRSKFTNEIFKWSRQISTLTFRKQRGDPKLHKIFAKVHWQQGTHNVARLHFLLANDPQEFAKFMIDYTTNHDESEHDESDNYAAQAVFQLLTYKKLRIAQTFFSFYCRDHPNIRETFPFKKSPLLNFVWLILSALQEKNFNHFVYLIEKYNPIMIMYCDFKSHLDKIAQLYFKAPSKSSSMGGGMFGELLKGFMPAGSDGSASGDNYSADEEFSNETFMKMSNSIQEQHSKDFYKQNMEADRVNPPGLITEPDMYEDARDDAETAPAAATAAVEMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1A9</accession>
    <name>A0A914Y1A9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1A9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13005.t1">
        <property type="protein sequence ID" value="PSU_v2.g13005.t1"/>
        <property type="gene ID" value="PSU_v2.g13005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13005.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15485" checksum="DDDA4313B607918C" modified="2023-02-22" version="1">MEEFFIHCYDNLLQKLGFEGYQKTEKPNIRFINWMNKLQKMGYTEEEINESLESFDIDKDEFISSQKQKIVEKDLVKKRTKICNPNIDHLTNQITVINTELKYVMQKLDEIEINEFLKNSPLWFEAAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1P2</accession>
    <name>A0A914Y1P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1P2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13379.t1">
        <property type="protein sequence ID" value="PSU_v2.g13379.t1"/>
        <property type="gene ID" value="PSU_v2.g13379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13379.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28164" checksum="F4EEA8A0BE7A07D5" modified="2023-02-22" version="1">MTFFGDIRFLAFIYFALLLDVLAAKTLGVPFFALRRHQTSMRHGFGPISQSKTDVFSSQFFTSGVKAAGRGKSVPSYRAGLLNDDEEDEGQSLPEIKEALDYEPTLVTLPPPPSVLAARNELKCFYLIRKFEETHKQKNSNENVPLPCASSVPTYQEFLSSHDSPSIEPTPEYLDPNPYPFHQIEPYPRSRSLNVPVNPQPQKILRFGNVVVYEYEIESEEEQEEEAMEVDEMAEDENVGVVDEEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1T7</accession>
    <name>A0A914Y1T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1T7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13420.t1">
        <property type="protein sequence ID" value="PSU_v2.g13420.t1"/>
        <property type="gene ID" value="PSU_v2.g13420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13420.t1"/>
        </source>
    </evidence>
    <sequence length="421" mass="43729" checksum="28E8A8F1D5DAF339" modified="2023-02-22" version="1">MKSSTIAVVNAENVDIIVTEASEPLKVTTVETATTAKIKQTTIVPVTAQNVDATTIIAVIVPKEEAVEATTTNASTATIIVASESTVPPAIETVQPSESTTIGNAQSIVGETIQPTIENATISIVPIALLGEGQIVVGGSTTSEPETTVLNTESPLTIAANLTEIPVIPVKINEETIVTSEASTEQPSTTKLNIVPVIIPIEDEKTVNPETKILAEQTTVNPITAENIDETIQPSEATTIETVKVAIVSVAPLGEGQIVVGGSTTSEPQTTILVSESVSTNEVLSQDVTDIPVTTVKNNEDTTINANQETIIPVVLISEVAVKSIETTHTSEVFSTAAPVTVIAPEATTKIIASEVTEIPIVTSAGIIAEIIAHGSTIKPVIQDSVSTSATSDIPNAPEQTTLEPQNVSTDSPKIPKPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y378</accession>
    <name>A0A914Y378_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Fibulin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homomultimerizes and interacts with various extracellular matrix components.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
            <location evidence="1 12">Extracellular space</location>
            <location evidence="1 12">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y378"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14640.t1">
        <property type="protein sequence ID" value="PSU_v2.g14640.t1"/>
        <property type="gene ID" value="PSU_v2.g14640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000139">
        <property type="entry name" value="Fibulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000020">
        <property type="entry name" value="Anaphylatoxin/fibulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017048">
        <property type="entry name" value="Fibulin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF89">
        <property type="entry name" value="COMPLEMENT COMPONENT C1Q RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036313">
        <property type="entry name" value="Fibulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01177">
        <property type="entry name" value="ANAPHYLATOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 12" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037987704" description="Fibulin-1" evidence="14">
        <location>
            <begin position="20"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="451"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="494"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="538"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14640.t1"/>
        </source>
    </evidence>
    <sequence length="738" mass="81173" checksum="FBCC8A356ECE2309" modified="2023-02-22" version="1">MKKFVFYLIAIFQISTIFATELSRCCSGGARHYIETQTCLALKSAGSSITCSRTASICCLRALLDNSCNAGAKLAKRHGYCSMNVNGQGGGIERECCDCCLLAKDLISKNESCIAPKGFSTVCMQSFNDCCKSNRSNDYEDDDGPISLNTNSNKGNDRCTTARCEHFCNDRGGNSVECSCRPGYDLGPDGESCIDIDECYNFPCNQETETCINTNGGYFCESKHDYSIPQPAFLIQRLKKKPYYFSGGKSQRISVISPLANALINQERFYENDIQTHLCSKGYQKLSAKNECIDVDECLLLLSDCLESQRCLNTPGSFKCIRTLSCGTGYALDSDTEECKDVDECTLGTHDCGALYQCRNTQGSYRCDPKKCAETEIMNPTTGECASIDCPTGYLPKDGRCEDVDECLTTPNRCSIYEECINSPGSYRCQEKGSFCSFGYRIDKDTGFCNDIDECAIPSLNNCGAMMCINLPGSYKCRCSAGYEFNETIMKCEDVNECKKFAGHMCSLHATCENTIGSFKCFCKPGFTIAADGRNCDDVDECSNGVARCQQKCVNTPGSYQCICDRGYQLSADELTCEDIDECSNWAKSGSQLCMGNCINTPGSFKCTCPVGYDIQPDGITCKDIDECSQGACHGSNNICVNTLGSFKCQPIYCPPNYIPDKNYKNRCIRSPTLCNSVSVEICKQYPAHISWEHIAIPKHVNISSQRTSVTLFSMKGPSNPNAAMQFELRVVKAKTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3M4</accession>
    <name>A0A914Y3M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3M4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1383.t1">
        <property type="protein sequence ID" value="PSU_v2.g1383.t1"/>
        <property type="gene ID" value="PSU_v2.g1383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1383.t1"/>
        </source>
    </evidence>
    <sequence length="623" mass="70958" checksum="45C174BF43D2D3F8" modified="2023-02-22" version="1">MNQQFRATPIVQPIRLRIPPPLNLELQKVAEGRYYQIGNDKRGKSQARIWIDTPSDDSKVFLYRHSEEYSSEHSDVFVCIQCSRHSRVTKFEIRRLENEEIELWEQQTHYPSCYRSKPEIEAIQAKYDRKRTFNGSSNASFNNGTLNSSLNGTLPSTENSFNTSRSSHNTSSKSLNRPKNDYHYLGHRTVPDGDYIFGVNEKGSLKTRILVRDEFDRSLGRVYSFHPAKRLDGKTIFYCRHCNPKKYVPVIAGEEDGRFIVREAPLARHESNCIPTSYDELIEKQHELEEKLQRKGVPIYDSSNISANGDETIPRRRGRTRSPTIAVSREPTPVEEERIQTRSRSRSRSRSPRANSRSPVPLNTSIGSISRGRRPDISIMRIVSNRDWRCEDPHNIGPGSKLFIFTNIDAGIGREFDFIEFKMDAAFFHCKDCVRLTANRQRTKGHIKFINGDIEVREGRHYPTCRAYEIKEIPKALPENERPDDIVVVGDIDMQDVEEPSPIVKVTRSASKTVVSLRPPQTTATSSEEASPSLSPELGMSKKRDDTESLPTPPPSQQIKLTFPGSSLSSAATSPFAQTINFVPKILARDEIVFYNVPSSSQMRAASRNLEVEYNKDGPCFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y439</accession>
    <name>A0A914Y439_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y439"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14205.t1">
        <property type="protein sequence ID" value="PSU_v2.g14205.t1"/>
        <property type="gene ID" value="PSU_v2.g14205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000212">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000008">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="43"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14205.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26954" checksum="6DA753185C04BF29" modified="2023-02-22" version="1">MPPSFKELQAELEEEIQGVNRYNPNNIEKLELCISLMIKENVYNKDILLTVLKLYQLNPAKYNEHVVCQVLLKTMMVFPRNDYALAKYLIDANRINSPELRKVTDMGALLESCNFGTFWRIMRGDYKADDKFKQPQVYPAVIEPIVGFEDAMRNFACQVINVTFQTIDKDELLRLLGNISEPQMLGYAKVYKWEPKADGTLFIQNHEDTIKSRNIEEKLRFEQCLGIFRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4V7</accession>
    <name>A0A914Y4V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4V7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1447.t1">
        <property type="protein sequence ID" value="PSU_v2.g1447.t1"/>
        <property type="gene ID" value="PSU_v2.g1447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="1">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="2">
        <location>
            <begin position="180"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1447.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33679" checksum="E4494CA30D27C594" modified="2023-02-22" version="1">MLRSLSSIPPSRITKAPVERARLYFLVCWFHALVQERLRYRPLGWAHSYEFSDADLRMACDTLDIAVDSVALGRNNGSSDKLPWKALRTLFSQCIYGGKIDNKFDQTLLDCFLQKLFTSKAFEDDFVLINNVDGKSSPLCIPEAHSHDELLQWISHIEHLQMPNWIGLPNNAEKVLLTVRGQELIRNMLKMSDDELAYNDTSEKEQKAPSWMIVLAETATRWLSALPQNVTKLKRTKDNIKDPLFRFFEREINLGLKLLSDIRCDLTDILADKFLRHGIVTQFLNLLLQWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5C2</accession>
    <name>A0A914Y5C2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5C2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14440.t1">
        <property type="protein sequence ID" value="PSU_v2.g14440.t1"/>
        <property type="gene ID" value="PSU_v2.g14440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14440.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21544" checksum="3E28194BBAD6AC67" modified="2023-02-22" version="1">MDSNEAFIARSIEQNQQIVQTHALNCEKCKIWKMVIIATICVAIASIFVVLPSKPPNSRNTRATPVIKSYRIKWSKHVPGNQKSYCNIGFLVLEGTHVNTYKQDKMPLFSRIVSQETVDNILSMKQILFAEEIDIDITDEIDGMETDKLITPQKTNNPSSGFDDSVNEGDGSANLIISLTRKEKKLSNNATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5I5</accession>
    <name>A0A914Y5I5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5I5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1295.t1">
        <property type="protein sequence ID" value="PSU_v2.g1295.t1"/>
        <property type="gene ID" value="PSU_v2.g1295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1295.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9651" checksum="8989722BA2AE2073" modified="2023-02-22" version="1">MFETVFSDDHQLDINGEYLNTNSIRPEEFLYEGFIKDDPGSHVYGSIMDGVFDGHIILSDGTSLTVEKASRYFSPDERPKNYHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5M8</accession>
    <name>A0A914Y5M8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5M8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14070.t1">
        <property type="protein sequence ID" value="PSU_v2.g14070.t1"/>
        <property type="gene ID" value="PSU_v2.g14070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14070.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13908" checksum="128128F33B18BE64" modified="2023-02-22" version="1">MEVSAFSSCQQACISQNYKGFDALSDVKNVDLRCSVSTCISHCINDQILECGDSNRLGQLYNEISGAQMLLGVEQIYGSGTKETAKFVGFEKVPASCRLLIIRSVVAAGNFDGRLITNNTSKDNIKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y661</accession>
    <name>A0A914Y661_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y661"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14735.t1">
        <property type="protein sequence ID" value="PSU_v2.g14735.t1"/>
        <property type="gene ID" value="PSU_v2.g14735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14735.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15634" checksum="F25A126C822DEA44" modified="2023-02-22" version="1">MNYPFMLLYGEAYVLDYPRALGAIMACGAYVKKLSEIEEHGEMPHFHQNSARFRNQINQTVLYMSKILDAQAAKQWNGENEYTWEGFLEYVTDSSKKLENYNFVENYHFVEISHPIILAASVGILGIILYRYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y777</accession>
    <name>A0A914Y777_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y777"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13484.t1">
        <property type="protein sequence ID" value="PSU_v2.g13484.t1"/>
        <property type="gene ID" value="PSU_v2.g13484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037297110" evidence="2">
        <location>
            <begin position="19"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13484.t1"/>
        </source>
    </evidence>
    <sequence length="468" mass="51523" checksum="D4A283C4F586B079" modified="2023-02-22" version="1">MVVCKVLFLNILILFCNAAPSHPSAAAPTPQPVLQIAQKLLSNIGRFPTAIQEGMTGKTGEIRKIVSSALGGGIISQLVENPIQAAGSLGFDLDQFGINKTMLENSIGLSPDKAWQTNLLPTMNNKGDLLFSNQFKAVGPTTPVGPEPLYIDGKKVMPQNEDAVLNGIFGEERNSLKQVQPQKGRRLESAQYYGSEKPRMRIQENRPTQNAFVTDSYAQNIPSQRFQNLPVPPPPLPVSPAPPSDGMDSANSIMNSVVPFINTPQMPTFNNDNTGIIDENRAVAHAINRVSNGDAEIRRVPMARVPEFNKMNAKILSLEQRLNEQQELLAKQRGEEKELKVQKILETLKFGKGNRLSALQKHLRYSPEAVNDDLRLDTNPLKPLPQIECECENVSLDELKGTWAQGLASDSLISRLNKGIGKIFDTNAAKLECAEISVTPPRDYDPQYSHFVLGVRIQNATNVVRVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7G7</accession>
    <name>A0A914Y7G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WASH1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7G7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14692.t1">
        <property type="protein sequence ID" value="PSU_v2.g14692.t1"/>
        <property type="gene ID" value="PSU_v2.g14692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028290">
        <property type="entry name" value="WASH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021854">
        <property type="entry name" value="WASH1_WAHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331">
        <property type="entry name" value="CXYORF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331:SF1">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11945">
        <property type="entry name" value="WASH_WAHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH1 WAHD" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14692.t1"/>
        </source>
    </evidence>
    <sequence length="464" mass="51009" checksum="AA02D3588FF56556" modified="2023-02-22" version="1">MIMLKPVLIPPDCPNHQASHYITASLSQVYKAADEIFNRIETRLDKCKENAEKIQKRISVVDDKIENVILTHRTRYPDAKMNTLNALFEEEDFSSATLKINDLLFAGDSISNQSLKDAITRKKDFGYAFSKGKHFDSFKRSNFKDSLNFCELLDEEIIFSEKGKLAKRKDKFDFEAEILLIYDSIGKGFDADPIAYKPGFGALNTFDFPDVLPQLSGITTSMNFVEGGEFQSIAPSLRNETTTSVKDNTLKEMPSLQSQPIANVEPKKEKAPEPELPQILPIISAPLPPVSIVSAPVVVDVIIPTLPTTSVSVSSPPPPPPPPPPPPLLAASSRKSLPQLPDLSKGRFDLMEAIRIAGGAKNAKLKTVSLTEKNTLPSSSSSPKSIVGDDTGDDLMSSLAKALETRRKGMAGNSSKKLQRLENKKSSNRSTGPSEAFSRLRESLPVIPNDDENEKHSDGETDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y954</accession>
    <name>A0A914Y954_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y954"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15806.t1">
        <property type="protein sequence ID" value="PSU_v2.g15806.t1"/>
        <property type="gene ID" value="PSU_v2.g15806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15806.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28363" checksum="965C58DC66A1FE6D" modified="2023-02-22" version="1">MRQIGKFLLCKLTVGEIVDTWKIRRLLGEGGFGAVYEVVNTKTELSYAMKTELMSEALKVLKMEVYVMRQANTNKAKHIVQCEDTGSYNDFLYVVMTMVGKSLQDVRKMCPGQKFSLGTALSIGIQSLEAIEELHQIGFLHRDIKPSNFAIGRPEINELRKVYLLDFGMCRRYTDDNKQIRRPRSVAGFRGTIRYAPLSCHIRRETCRKDDIESWLYQQIEITRGALPWRSLEEKNEVCFLSSDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y987</accession>
    <name>A0A914Y987_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y987"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15322.t1">
        <property type="protein sequence ID" value="PSU_v2.g15322.t1"/>
        <property type="gene ID" value="PSU_v2.g15322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900449">
        <property type="term" value="P:regulation of glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09628">
        <property type="entry name" value="DOMON_SDR_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042789">
        <property type="entry name" value="FRRS1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902:SF1">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036906462" evidence="2">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="53"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15322.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21480" checksum="A51A0DAC57F300E9" modified="2023-02-22" version="1">MTLKSLIALAGIVAVACIVTTFSQSLSGFNTSQCGGTKRCINIPENCQIQGNCQYQISYAPSRDGKSMIIELFGRRDSPQMQYVAIGFSSDARMGNEPVAACIAGPNGQAQLSYSYNQEGKRNIPLGPINPSDAQLLSSAVTESSIYCQFSQAINPTTNPSLPNLQRPFQLLVARGPVQSNGQLGHHTSRQPTSFMTQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9E5</accession>
    <name>A0A914Y9E5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9E5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16817.t1">
        <property type="protein sequence ID" value="PSU_v2.g16817.t1"/>
        <property type="gene ID" value="PSU_v2.g16817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="147"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16817.t1"/>
        </source>
    </evidence>
    <sequence length="827" mass="92541" checksum="27F3656473266A10" modified="2023-02-22" version="1">MSQIQFCQKPDKFDIITIPAFNCQDWHEQQVLDWFKGIDDSVLPYLPAFRKAKITGRELLIIDDSQLFQYGIRSTFAREKILNAVNLLAYYSYNVRDENLQKLAMLISIDISTLIDAILKASPIIDRFNNGSDQLDPSILYTSYFQFVYIRNTESKPTCGINFQSVFNGVNLITSIDPDSPAAKCKKLSAGDEIIEINDETVVGWNYQKVKEKLKSVNYRHDQKASDSKLLINRRPVDDTTSSTLSKSKTSDTLIAGDDEENRHKLELDFTLKIQPDMFCSREGSRRSLHRRRSSSFSLTNGTNRGDPDRLSMPVLKPSVLIASKMIENDKRLLYRRASVWSDSPPASFVAANRKIQNGLESKALTHLLDCWTEPKARPNGHLRLVRASRVAKAIITKLNDNDVAEDNEDEEVGDEPKTEDYSNIEIVMPVEAEKLKLSSPSILDADWNAPVQEITGLKLTNKRIHLESTSSVAPDSPLSAAFNKITKFWQNDNGSVSALSTSYTSDKGDMSIPSTPISKNALEKIAKEKSRQMPIISIQNGLNSRGSTVSPEPTSSGLSSPRYCTAKAKNHLAPLAEPEFDDEEGIAAQASIEEISDNGDVNINTLTSIGLQNYVRVPCHQITGKTFESWVRRQRIESDPIYPKQKKPSQWVKSWIVLVDDRVLLSYSNQLARSADLALDIIKCSFNTQPVDIKTTKKFVFCLSSGRTWYHFAPYHQEEYLRWVSKLSPNVQIIESSPSSNSPPETIMNDSQQSSSEDFTDIPTPSSPSASNTLPRTVFNPSKFLLRTSTRKGSITGYSSNTPSEILSHSSAAGSIDDIKGAKTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAQ3</accession>
    <name>A0A914YAQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16362.t1">
        <property type="protein sequence ID" value="PSU_v2.g16362.t1"/>
        <property type="gene ID" value="PSU_v2.g16362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16362.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33139" checksum="601DB58AEBDEFB39" modified="2023-02-22" version="1">MVTTVQRQQLAEATPYLSKRDYSDLPQRWKYLENTLCTKKKLRGTHEIIIVEKFKSVAIGFNHFGKKRPVVLYREYYKDFKDLKVGDTIRGVLGKMYVHVRSPTVIFTDLYVASVCNTALSGLFHEYDTYVSNGSLKVRDFTSEINQIELVYGREILFAEFGAILIPEKLSKIFSFGGLNEKKEVYGMGSIKYGINGFGENRYACWTFHLDFNIYVEQILYAKCVRGHFQIVPKADKKRRLAINTGALVARMVERDFGGNDTVRMFSNIIFLNFNDILSLNPGTNPGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAT8</accession>
    <name>A0A914YAT8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16404.t1">
        <property type="protein sequence ID" value="PSU_v2.g16404.t1"/>
        <property type="gene ID" value="PSU_v2.g16404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="582"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="628"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16404.t1"/>
        </source>
    </evidence>
    <sequence length="769" mass="85847" checksum="94FA7D9BBAA05747" modified="2023-02-22" version="1">MGSLNIHTQQVYAAISPIRNSITWTNNNKYFAFATLNDICFAKAECLENYASSSIVKTLPLNKKPACLSFAKSEASSNKDVLFIIDGDGRLLVYDVVQGDEEDEISFELVETGEKSGYPSDFCRGHVFNNDSVINFWCRRNILFCRKRGDSNLYQYKFKVDVKCFDSLIYENSLFCVVGCVNGNVHFFETMLNDLSYFALIGLFSPYPIPVLNVALQSLDGVFICAFNHATKVTALRWEQTEQETSPNTVLKIRRELQFCGKLWYMSTDSVVSDFTTDIATLKFDSSGTRLLIVTNDRDFGVYKFQKDFENQGKFTWQNLVHGGEAKERPFGYCGGSFTASGNRVLIYTTKGGFMIFDLVQQSEDFYLAVEAPPPITGHTSAISAAEWDPTGSILFTAGTRSREIHIIAFLKDGSYAQIARPESHQYDISCLTPLSGLTMIVGSDELPFRIYKASANYCTSLKALTGISANELKKCEIKLPTVPFFKQPVLGVLNIAANDVEENYDTTEAETVFERRPTTNQLLRFTFWEVAESLYGHANSASAVCTDTEAKWIATSCQATSAEDAVILIRKVNDWNIQHKLYAHQLTVTKLSFSPNSKHLLSVSRDRSFAVFDIDNDSNWNLKNRVVEAHSRMILCCSWTPDSNFFVTGGRDSQLSLWQLNAQDAKSCIFTQKTSASIMALDIAQHPLSNDKWLLAAGLGNGEIHLFTLSPLSEDSQLVSLVMIQASDAFSLAITTLKFRPVWNNSYSIAAGSESGLIKVFMIQPQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCK3</accession>
    <name>A0A914YCK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17157.t1">
        <property type="protein sequence ID" value="PSU_v2.g17157.t1"/>
        <property type="gene ID" value="PSU_v2.g17157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="95"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="187"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17157.t1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39194" checksum="21E43A4CC45EDCB1" modified="2023-02-22" version="1">MISVENNDSQNQQKSVFAAFLESLYRFILGSIAGACGATAVYPIDLVKTRMQNQRSFRGLYRGLLPQIVGVAPEKAIKLSTNDFMRGQLTFNGKISLICEILAGGCAGAAQVIFTNPLEIVKIRLQVAGESKEPKKINVFTVLKDLGFIGLYEGVQACLLRDVMFSMIYFTAYAHAKIATQDENGINHPLSLFISALIAGIPAAALVTPADVIKTRLQVAARVGQTTYSGVIDCIKKIMKEEGFGAFWKGTIARVFRSSPQFAVTLLTYEMLQRIFYVNFNGTNSAELLKASENSTILENTVTDKIKYSVENTNELLISSVAVLTLLINVFIGLTTTVYLYRSKKERKSKINELPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCS4</accession>
    <name>A0A914YCS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCS4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15266.t1">
        <property type="protein sequence ID" value="PSU_v2.g15266.t1"/>
        <property type="gene ID" value="PSU_v2.g15266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15266.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26416" checksum="A5EC87E57846A6A8" modified="2023-02-22" version="1">MHDNYRRRVKSKLKLVWTTLLILSTFTLSWGLCVLYFVLVCIDGCIFVYRYSVSFQVGFLLNSTVNFLVMVKLLLNPLIYALRMKHIRKSVQACLRLTCFCCFRHLKANSMTNLTTNNGLYSSVNEKIEKSDSTTQQSLHKSIHRTTSDKICKPRKTSMCPRQIPKSALRSSSTAFENRPRGISHDDVATIIRGEPDDSIQLLENISQRNSRNRASFHQEFWHDTDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCW5</accession>
    <name>A0A914YCW5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YCW5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16583.t1">
        <property type="protein sequence ID" value="PSU_v2.g16583.t1"/>
        <property type="gene ID" value="PSU_v2.g16583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.54.20:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4380:FF:000001">
        <property type="entry name" value="Translational regulator CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.54.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="entry name" value="Translational regulator CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002469">
        <property type="entry name" value="PRK01712.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="CsrA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="1"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="682"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="623"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16583.t1"/>
        </source>
    </evidence>
    <sequence length="872" mass="96156" checksum="B397DCBD992BB31E" modified="2023-02-22" version="1">MNQFKDVFLGLDKRNYSRATTSQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKHDAIQFAWELLTSEKWFALPKERLWVTVYESDDEAYEIWEKEVGIPRERIIRIGDNKGAPYASDNFWQMGDTGPCGPCTEIFYYHGDHIWGGPPGSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERIAAVLQHVNSNYDIDLFRTLIQAVAKVTGATDLSNKSLRVIADHIRSCAFLIADGVMPSNENRGYVLRRIIRRAVRHGNMLGAKATFFYKLVGPLIDVMGSAGEDLKRQQAQVEQVLKTEEEQFARTLERGLALLDEELAKLSGDTLDGETAFRLYDTYGFPVDLTADVCRERNIKVDEAGFEAAMEEQRRRAREASGFGADYNAMIRVDSASEFKGYDHLELNGKVTALFVDGKAVDAINAGQEAVVVLDQTPFYAESGGQVGDKGELKGANFSFAVEDTQKYGQAIGHIGKLAAGSLKVGDAVQADVDEARRARIRLNHSATHLMHAALRQVLGTHVSQKGSLVNDKVLRFDFSHNEAMKPEEIRAVEDLVNTQIRRNLPIETNIMDLEAAKAKGAMALFGEKYDERVRVLSMGDFSTELCGGTHASRTGDIGLFRIISESGTAAGVRRIEAVTGEGAIATVHADSDRLSEVAHLLKGDSNNLADKVRSVLERTRQLEKELQQLKEQAAAQESANLSSKAIDVNGVKLLVSKLSGVEPKMLRTMVDDLKISWGVSKDVTDRVKAGELIGMVAQQVGGKGGGRPDMAQAGGTDAAALPAALASVKGWEQRMLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKSQQSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDK0</accession>
    <name>A0A914YDK0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YDK0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17374.t1">
        <property type="protein sequence ID" value="PSU_v2.g17374.t1"/>
        <property type="gene ID" value="PSU_v2.g17374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="5">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17374.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19456" checksum="6B8B3571A1194C67" modified="2023-02-22" version="1">MNVAPKGSIAHVWEGGTYAQIMKEMDTVTKNGHQAILSSCWYLNYIKYGADWGYIDNDNRRLRGLYYECEPTGFNGTQAQNDLILGGEAMMWGEFVDGTNLTPRLWPRASAVAERLWSDRAQTQSVDAAWPRLHEFRCRMMARGYEVEPPNNPDYCPDFWDPLYPDMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE90</accession>
    <name>A0A914YE90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17073.t1">
        <property type="protein sequence ID" value="PSU_v2.g17073.t1"/>
        <property type="gene ID" value="PSU_v2.g17073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037931655" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17073.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11834" checksum="AA0F879D3BFBF245" modified="2023-02-22" version="1">MNNTQFLLICLAATVLAIEGGRLRRQTQDPCAVILCDSGETCARVSPSCNNAGNCITKGICVANGMYQQQYQQYQQQQPQYSQYQQQLPYPVFQPNVFHQGVGLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFZ9</accession>
    <name>A0A914YFZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18378.t1">
        <property type="protein sequence ID" value="PSU_v2.g18378.t1"/>
        <property type="gene ID" value="PSU_v2.g18378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012957">
        <property type="entry name" value="CHD_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009462">
        <property type="entry name" value="CHD_II_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009463">
        <property type="entry name" value="DUF1087"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08074">
        <property type="entry name" value="CHDCT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06461">
        <property type="entry name" value="CHDII_SANT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01146">
        <property type="entry name" value="DUF1086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01147">
        <property type="entry name" value="DUF1087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18378.t1"/>
        </source>
    </evidence>
    <sequence length="753" mass="86316" checksum="3632C113755DA75F" modified="2023-02-22" version="1">MLRSLFNEKHRVLIFSQMTRMLDVMEEFCEFEGYKYERIDGSITGQHRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQQNKVMIYRFVTRNSVEERITSVAKKKMLLTHLVVRAGIGQKGPSMSKTELDDVLRWGTEELFKDGEPEKDSNGKEKKGNEQEIIWDDEAVEALLDRTVGDEPKEVKEGGKKKEHWTNEYLSSFKVAQYVTREADEEEEEPDREVIAETVNEPDPDYWDKLLRHHYEQEQETESQKFGKGKRVRKQLPPLLARVNGLLEVLGFNPRQRRAYYNAIMRWGIPPQDAYQSQWLVQDLRQKSERAFKAYTSLFMRHLCEPGIENSETFNDGVPREGISREHVFARIGILSLIRKKVQEFDRVNGEWSIPETRDEAINQGQLAPAFKLATVTTTTALDSSSRYGTPMETTKNEAKEEIVGIDSAIDTPDVSNVPTKKNEITKKDDTFKENVDAEMTGDVVPDAEKHEEVIKQNLPKFMFNIADGGFTELHTLWYNEEIAAVPHKEYEIWHRRHDYWLLAGICAHGYSRFGDVINDARFAIINEPFKSEQGKGNFLDSKNKFLQRRFKLLEQALIIEEQLGRAAHLNITQKSDERQTAQLHEHFADVEAIGESHQSLVKEAANDTVGTNVVLHKVLIQLEELLTEMKGDISRFPATLTRLPSITERLQLTERQILNRLTTKDPEAAAGLSPLPPPGPFALIKMLLPKKRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGX1</accession>
    <name>A0A914YGX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19556.t1">
        <property type="protein sequence ID" value="PSU_v2.g19556.t1"/>
        <property type="gene ID" value="PSU_v2.g19556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19556.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19028" checksum="0E214CE8D0B84DD0" modified="2023-02-22" version="1">MQAVGVRVGQDDDLAVTQAGDVVLAGVAADGHGQVVHFFRSQHAVGRDFPGVEDLAAQRQDRLEILVARLLGAAACRVTFHQEQLGARQVLADAVGQLAGQGRALRDLLADDQLLSLQARTGALDGDLRDLLAQFHVLVQQQAEGIVRRAFNEAGGLARGQAFLATARTTRGPTRLPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHC1</accession>
    <name>A0A914YHC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHC1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16708.t1">
        <property type="protein sequence ID" value="PSU_v2.g16708.t1"/>
        <property type="gene ID" value="PSU_v2.g16708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16708.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="21321" checksum="DC1DADF3F8EA2584" modified="2023-02-22" version="1">MDFSHSAAAVGSNKTEYKKTYHRQQYQQQYNRQTSNSHHSSYPHPSSSESRQQSSHYNNRHTNNSHHSFSHHHHYHHQEHRQNQNQQQQQYSNRQSNPHNSSYPHPHHHHHEHQQQPIFSHSQVFPRNYSYNSHVSITMMYHVSQETPMVITAMRNQTMKCDLQKKRILQECTNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHQ2</accession>
    <name>A0A914YHQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHQ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18849.t1">
        <property type="protein sequence ID" value="PSU_v2.g18849.t1"/>
        <property type="gene ID" value="PSU_v2.g18849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18849.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13984" checksum="0101F568CC02C7D8" modified="2023-02-22" version="1">MSTAYVELSNGVKMPLFGLGTWQSGPGEVAKALKMALTLGYRLIDTAAAYGNEAEIGAVLKEFISSGKIKREELFVTTKLFWAFNRAEDVEPQLKASLEKLGLDYIDLYLIHMPVAFDASILILILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI54</accession>
    <name>A0A914YI54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19168.t1">
        <property type="protein sequence ID" value="PSU_v2.g19168.t1"/>
        <property type="gene ID" value="PSU_v2.g19168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19168.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17154" checksum="C77A2AAA499A4F7D" modified="2023-02-22" version="1">MSFFSLTNIDIPAETTVNGEEETENVQGDGFAVLNNESTTKYFDGETQNLINKLIPVDPEKTAIFLTKLMPLVQQHFSPNGQIGVLPTVLSKGQILKKNDQKQIYAQISNILYSVNPCKFLSELYSTETALKYRIMSDLPPHIFGLGKTAIDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJE3</accession>
    <name>A0A914YJE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18978.t1">
        <property type="protein sequence ID" value="PSU_v2.g18978.t1"/>
        <property type="gene ID" value="PSU_v2.g18978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18978.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15847" checksum="10ED3E4460B044AD" modified="2023-02-22" version="1">MDSSKSDASNALSLKELLFMKSNNSIAERVKNFLPQIAKANAELEEADEETRQSMIFEQIEQLQDDSSSSDESDSSEDEDDPSTEDEKEKDKIKGGDHVEIVFTKFEERETHESSSSDEEEKKANEDDFIIRKSDKSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKM5</accession>
    <name>A0A914YKM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19898.t1">
        <property type="protein sequence ID" value="PSU_v2.g19898.t1"/>
        <property type="gene ID" value="PSU_v2.g19898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19898.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8947" checksum="DEF800CCA774AC97" modified="2023-02-22" version="1">MIDRFRTSINVIGDAFGAGIVDHYCKEQFAQHDLEHNRHLSNAYAHPEAAALLLKDKRLSNAKQHEGGGYNALSTEETPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMD4</accession>
    <name>A0A914YMD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2428 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMD4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2150.t1">
        <property type="protein sequence ID" value="PSU_v2.g2150.t1"/>
        <property type="gene ID" value="PSU_v2.g2150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF7">
        <property type="entry name" value="THYROID ADENOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="2">
        <location>
            <begin position="229"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="1">
        <location>
            <begin position="623"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2150.t1"/>
        </source>
    </evidence>
    <sequence length="825" mass="95471" checksum="D4A52F5385998D30" modified="2023-02-22" version="1">MLQSVTTTGKSNCDNDDEKKLLCQILNVSLSVGFLNQKINEEWKKSCCEKHEIFLGDYVFKTILEELSLPGQRTPTRLLDLSLAVKRLSIIFREEEIEYNLELATLMKNFISRYIRDPIPIVCHTVLDVMDNFMQSKLNLGESDNGDSKNILESLCQKFFERLTKFTIRALILFMKHTRCDLIDEETWTRLYAKIGHPELTTAITDLIIFHGIKLANENNGLGLHFDEMRRCLLEGSVEQRRAIQTKLLPKMFKSVELRNVFNNESQNLLNVHDEFYASADPIRAIEVILSMTKFFIFNPTSTALSWHDCVDVQLLAEAIVVDDVEVRMLAWHLICQNPRLTRPFSYDELLLARLFIASNMTEQSPGIRQKIVAEFKILMQRMRESYKLLKKKLTPENRDLFYELATSELFPTKTSDISSDDSCNTMILKNHKEFLRFIHDFIFDSIGEEANFNRKLLALFLIEIMHESEASYKNGAADLMYKELEMQSWLNQECYDQLRAVMSDDFEINQGIAERLLSKLPFKDIKRPHYDKIPLDFKNNYYKSRCFWKDIFAGGDQHLQAAMKNVQILIQKEIKNIEKDKEEYLGGYIPLTNLIIYVNGFFESGIYSQIENIIPWETYIPQTLIPLCLTVGKLVSPVVHSCAPEGFYPDDKSDDIDGKKGKERSKKSQQLLVNCWRTHKEISVVFKNFLQFAFEKNAAQSLSKNGMKLLPPNLLQNLKEYLWTQLTECRQIGAFEAAAATFQIICSILWKLEDEGKKENNIFLHDYSSVENGINNLCETRRSAGLPPLIVAILTTEPKQRNHAAFTNCMERMFAIQLQDPGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMM1</accession>
    <name>A0A914YMM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidylglycine monooxygenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMM1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20172.t1">
        <property type="protein sequence ID" value="PSU_v2.g20172.t1"/>
        <property type="gene ID" value="PSU_v2.g20172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028460">
        <property type="entry name" value="Tbh/DBH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00767">
        <property type="entry name" value="DBMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="4">
        <location>
            <begin position="73"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="5">
        <location>
            <begin position="213"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20172.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41409" checksum="D20056D344D5F0F8" modified="2023-02-22" version="1">MRACDQNGFSFKRKWITCDPRDIILSKGATNLFFASDVTEASNINEISSHKAKLFSPNIPPTQLESDIVVLSITAANLTVSDNKQWCLIKKLSEDLRTKKNHLVRIEPLITVGNEKVIQQIELYYCNNFDGKDSIEYNGTCQGEKPKNCTKSVFVWSLGASPFDFPKEAGFPIGGSEISGGFIMLKIEYVNQNPINDSSGFNLYYTPTLRSNDAAILELGISPTTANAIPPKQKSFVSNGFCLPECSAKFPDNGITVFGSRLHTHSLGKLVRTSIYRNGKRVGNLNFDQDFVYNWHIVDTLEPQITVEKNDMLMTTCVYNSQNREKITFGGDEPTDEMCSNIVYYYPAMEISACKSAIEDDALQTWFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMR8</accession>
    <name>A0A914YMR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMR8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2088.t1">
        <property type="protein sequence ID" value="PSU_v2.g2088.t1"/>
        <property type="gene ID" value="PSU_v2.g2088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF343">
        <property type="entry name" value="AMINO ACID TRANSPORTER SKAT-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="82"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2088.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38820" checksum="64B99D2973D2ACA3" modified="2023-02-22" version="1">MIGPGCLALPAAFKQAGLWTGFIMVFCFGLLNKYCMLQLVNSSQYLSRKKGDAKLDFGAVAYEAFDNSFERCKKFKNIANAIGNVFMITVLAVVFQYLVQDSKHTSELPWITNFNGVMSAAGSILYAFEGQSIVLVMENKLKHPEDMCGQVGVLSTGMNLVIIVYAACGFFGFAKYGSEVKGSITLDLPKTVEFTTVKVLLIIIVFFGSLIQFYVIIDMTWPTIRRFLTTKFFSSKFAFPLELCYRAILVTVTMVIAIAIPNLEEIIPLVGVTAGMSMAFFYPPVIDTITFLPGLLQKYKRASEDQKFKVKISIIFRLFRNGCLIFVACFGCIAGLNSAIRDLINTHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN26</accession>
    <name>A0A914YN26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YN26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20349.t1">
        <property type="protein sequence ID" value="PSU_v2.g20349.t1"/>
        <property type="gene ID" value="PSU_v2.g20349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20349.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24677" checksum="A0331811B511CF93" modified="2023-02-22" version="1">MNFHVLSIDYRGYGDSSGTSSEDGLIEDAHFIYNYAREKAPNKPIYVWGHSMGTGVSARFVAELSDKGMAPWGTILESPFNNIYDAVKNHPFAKPWLFWGKWFDKLMIDRWYASGLKMESDKSIQRFKCPVLILHAADDHIIPINLGEKLSESAKKADIDVKFIEFEANLGLRHKWIHRAPHFISIITEFFDYCEKHAKGKIAHNRQQEVHIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPF3</accession>
    <name>A0A914YPF3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YPF3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21318.t1">
        <property type="protein sequence ID" value="PSU_v2.g21318.t1"/>
        <property type="gene ID" value="PSU_v2.g21318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="322"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21318.t1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45701" checksum="4903AC48DC68B3B5" modified="2023-02-22" version="1">MNEFIDNEMVQALNYDEIKSYEDYRYISATEAHWHLSDFWMYRLSHSVDRLAVHLENEQSLYMGEDAGDEEMEKAKEKDSKLMAFFKANQEREKEIAKAKETIEKLKADKKPINHIKIPEKILYNKIGIDHVWDGKNGKWNPRKKTTKPKLCRLYNVNPKRTNCFYLRRLLMAVPGPTSFENIRTVDGVLYPTYREACVALGLVVNDKLYEDTLFEALNHTTPYQFRYLFARLLAHCDLGNPLELFEKFEDHLIKDLLKKWSKDDAKNVAWRKIVKSMLNQDKHLSDYPELEAYMKKIGFEDEDTIDLKSLYEEGIANYTVMNKEQKSIVDTVTVKLQDPTDKNCCIYVDGIGGSGKSYTFNTIRKLAMGKGFKVVIMAWSGIAASLYPMGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPT4</accession>
    <name>A0A914YPT4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPT4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21471.t1">
        <property type="protein sequence ID" value="PSU_v2.g21471.t1"/>
        <property type="gene ID" value="PSU_v2.g21471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036720604" evidence="11">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21471.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12972" checksum="783E2D9217483B70" modified="2023-02-22" version="1">MQSGVWWRHLVAGGLAGCMSRTCTAPLDRLKVFLQVHSTFHKRYNLFSAFQFLYKEGGFKSFWRGNGINVIKIAPESAFKFMAYEQLKRMIQRLKGSTDLSMGERFMAGSTAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPX4</accession>
    <name>A0A914YPX4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 21</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71739"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71755"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:72701"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71747"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71751"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71759"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71743"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPX4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21073.t1">
        <property type="protein sequence ID" value="PSU_v2.g21073.t1"/>
        <property type="gene ID" value="PSU_v2.g21073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21073.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9320" checksum="CB24DC36C6229CD6" modified="2023-02-22" version="1">MEKFKDGGRQITAGGSAGLVEVCLMHPLDLLKTRLQISGGNYKGLTDCFNQTLKKEGIMGFYKGILPPIMGNKTLQPPARRNKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ12</accession>
    <name>A0A914YQ12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQ12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19455.t1">
        <property type="protein sequence ID" value="PSU_v2.g19455.t1"/>
        <property type="gene ID" value="PSU_v2.g19455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF32">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ZP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19455.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11790" checksum="BEB09FCB032FA70B" modified="2023-02-22" version="1">MQRLRSANPRGISFSVTVIVSFHPAGFITKNDRAYHIKCFYMEPDEIVTSGIEVSQIPTQELQDSMTMPKCEYSVRSGSPTGPPSSAASVGEVVYHVWECTGTGMGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQD8</accession>
    <name>A0A914YQD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DksA C4-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19579.t1">
        <property type="protein sequence ID" value="PSU_v2.g19579.t1"/>
        <property type="gene ID" value="PSU_v2.g19579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900378">
        <property type="term" value="P:positive regulation of secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.910">
        <property type="entry name" value="DksA, coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035404">
        <property type="entry name" value="DUF5405"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38777:SF1">
        <property type="entry name" value="DNAK SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38777">
        <property type="entry name" value="FELS-2 PROPHAGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17399">
        <property type="entry name" value="DUF5405"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUF5405" evidence="5">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DksA/TraR C4-type" evidence="4">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5405" evidence="5">
        <location>
            <begin position="196"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19579.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30913" checksum="7DC3CB8FDFEFBCDB" modified="2023-02-22" version="1">MIRHITKGGVIPRGDSRAAQSGVGKISQYRIVSRGGALMSCSHSVVLLNNALKIAVMKNGDLSLIQLCLDKEKRDITESVIAIYQNELNLLSDVVNLLVKRAVFHKQISSVDELTKLTTELANYCADEQQAELLERQINAARVKHCGASALVCEECNAPIPAARRAAYPSATRCVSCQSVFEAKQTLPENGMSIRIEIGERYVVTSDSFQFILHEKKRAESGKNAGQEWLAVVGYYPKLSQLVSGLMHHDILTGSAKSFADLNAQVEQLSKRCSEAFGSYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQY8</accession>
    <name>A0A914YQY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2430.t1">
        <property type="protein sequence ID" value="PSU_v2.g2430.t1"/>
        <property type="gene ID" value="PSU_v2.g2430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2430.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10627" checksum="573706FC446F7DD9" modified="2023-02-22" version="1">MNNLVNLYLRENDKVGQVINDGIFVESLSNLYRMDLVKCNITHLDMNVFINLTKLEILELSKNPLFSLPSAIKVLPRLFALWMFQTNVTTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRK7</accession>
    <name>A0A914YRK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2002.t1">
        <property type="protein sequence ID" value="PSU_v2.g2002.t1"/>
        <property type="gene ID" value="PSU_v2.g2002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06624">
        <property type="entry name" value="STKc_ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000054">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046873">
        <property type="entry name" value="HisK-N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043969">
        <property type="entry name" value="MAP3K_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025136">
        <property type="entry name" value="MAP3K_TRAF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF394">
        <property type="entry name" value="APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19039">
        <property type="entry name" value="ASK_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20302">
        <property type="entry name" value="HisK-N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13281">
        <property type="entry name" value="MAP3K_TRAF_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="446"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="758"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="863"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2002.t1"/>
        </source>
    </evidence>
    <sequence length="1253" mass="140731" checksum="A6796ABB3220FDE4" modified="2023-02-22" version="1">MDRFQGFSKKGHLNALTFGERIKQALASVQIDANAHAKEKFLSDLRKVQDMGSEEANQFLQCMRTRLDNPDVMAPDTVIQIMLCYRDTQQYDAMINLVDDLKKIGRKDIVMVQAVRFHYAFALNRRNQEGDREKCIQTVKDIMKTADAKKEPISPDIVCLAGRVYKDKFIASNYEDKEALEQAIEWYRRAFDISPLEYSGINLTTLLRAKGEQFEYNEEMQQIAVVLNSLLGRKGALQNLKDYWDVATFFEVSVLAEDYKKACQAAQAMAMLKPPTWFLKSTMENIKLISRCAATISPIEKEKQTFLFWTEFFVEAIESGKEITSSRFPVLIQEVNKEYMPSYITINVNDVIILSHVLENSQKKSPPPGIHRWEFKVGDIRAVSANKRDNRSMFLYVHDNSEDFCLTFPSVEICNRVIEMMECDGKVLHDCGVENQIQYEYDLDPNGDKVILGRGTYGTVIAARDVTTQRSIVVKEIEVQNDEEVQPLMEEIQLHSTLSHENIVKYLGSKVEQRENGHDVFLIFMEQVPGGSLSSLLRSKWGPLDDNETTMAFYARQILEGINYLHRQKIVHRDIKGENVLVNTYSGLCKISDFGTCKRLAGLNPVADTFKGTLQYMAPEVIDHGQRGYGPAADIWSFGCTMIEMATGKPPFIELGLPQAAMFKVGMFKTHPEIPKKLSELARNFIKICFEPDPNKRPSAAQLLNDPFITQNTRGSVKKAKQHANSKFMRERSVSHLSGIGITQNNLTAGNINNATNGVGPITRSNSTKYPSKTISSAITPTTPITPTSELQTRNTKGTSGLRLRIEAPNGIINNNNNTLIAAPSQPASASPNLCQPSYLHTSNPFEANQMLIYQQQQQQHYQSGNSLGGATSPSILQYSQPSSPLRDLQTPLTASPSFGDTSPFSTMPSSSSIPEENINGFFNLQKDVELRKTLAALMVEHEPEVIQRWANAIEAELGHKIFSDEILKILLEGIRNYLLQKDAEKFGSVLRDVGNEVGQEQKSQLTVAMYLFPNSVHPALKHRGIKPHWMFSLDDLIRSGVQAALTLLAPDQPAHNLIQEADKQYGQNAAAAIVAATANNQVLGIETATWNLPELNQQHAFYADQIRRLYEDLIVVERDYKTLLEQTIQEKRQLADGIVGKISPIIDFIHSTSSEISPKPHQILNNLQPPLAVVLNHENPDCDEENCQEFLTRIGCDSNTINIVQKNGYTKNDLVDFVTREELMGLGVTYVGFHVSYSTYLNPSILVAVQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRV3</accession>
    <name>A0A914YRV3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 11">Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp-1 and ncbp-2 that interacts with m7GpppG-capped RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2903.t1">
        <property type="protein sequence ID" value="PSU_v2.g2903.t1"/>
        <property type="gene ID" value="PSU_v2.g2903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000128">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2903.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18884" checksum="A8C105A8F52E93F9" modified="2023-02-22" version="1">MPALAPKEKDKANELSAYRDQRFSGTLKEQEKMLKLSTTLYVGNLSYYTTEEQVYELFRRAGDIRRVIMGIDRYKKTPCGFCFIEYYNRDDGENAIRYINATRLDDRTIRTDWDAGFVEGRQYGRGRHGGQVRDEYRKDFDAGRGGWNKEIATRRAAHEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSU5</accession>
    <name>A0A914YSU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3765.t1">
        <property type="protein sequence ID" value="PSU_v2.g3765.t1"/>
        <property type="gene ID" value="PSU_v2.g3765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3765.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="30114" checksum="3EA96A234A22821E" modified="2023-02-22" version="1">MNSIRSGNYGNNGNGNGQNYGSSNYNLGNNGFSSTAAGNTNFNVVEGYGNSGGGGSNQWTGQQINNGFNGFGSTNSNGGTINGLSGISGTTTTGNNGFGINGFTSNGNSNFNAIPVRIITTGGGYGCCNMNSFGPCCQPQQQTFTQPQTYTQPQTFNTFVPNHSSFGGLQSNPINDVPGPIPHASYSPPSTSPSLSSSSATISSPQQSPPTFDYSNTLQNNVPFSPQPLQQKQNDAITSATFDFYPQQHVNTNQYLPSSPYQSQQQQQQTQEYQHFKNPYGSAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT41</accession>
    <name>A0A914YT41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT41"/>
    <dbReference type="WBParaSite" id="PSU_v2.g333.t1">
        <property type="protein sequence ID" value="PSU_v2.g333.t1"/>
        <property type="gene ID" value="PSU_v2.g333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08377">
        <property type="entry name" value="C2C_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000167">
        <property type="entry name" value="Multiple C2 domains, transmembrane 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g333.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="55855" checksum="28CE4320C6032CC1" modified="2023-02-22" version="1">MDEDAGSILLLLTISGTSASANKVSDLRDFVGNRNDILEKYSLKHSLTAIKDIGHLTVKVFKAENLAAADLGGKSDPFCVLELVNARLQTHTEYKTLNPEWNKLFTFAVKDIHEALEITVFDEDPNKKVEFLGKVVIPLLKIRNCEKRWYNLKDQTLKNRVKGKILLELDFLWNPIKAAVRTFNPREKKFISQEPKFKTSMLMNSVNRLKTFGAYIVSYKAFIDDCLSWRSYPKSIFAFLTFVTFAYFIQIHHFPMLLLLLFVRFHIYHKVSENIEIRFRGCSIGGGGSGSKDEEDNRISVESDDDEMVNDQKRPEFRRAMTAPPSMNPPKNEKSVSIMDRFQAIQDILQMINLQLDFIASLLERFRNTFNFTVPYLSYLAIVILCIVATILYLIPIRWIIMVWGINKFSKRLRNPHYVDNNELLDFLSRVPSDNELRMYREFRANCEDPSPPSHSNSSSTSATTAMATMATTKNATHESSVKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT68</accession>
    <name>A0A914YT68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g388.t1">
        <property type="protein sequence ID" value="PSU_v2.g388.t1"/>
        <property type="gene ID" value="PSU_v2.g388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g388.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12210" checksum="AB76D75E4DEEBA33" modified="2023-02-22" version="1">MGARLASIHSKAENRFVNDMAGFGSPLEKSQTTIGAKCFNGIWTWTDGSEFDYANWQDGRPIYKDTCGVTWADIPSYLNENTVEHFYWEDISCDKQTPTAVCKKLAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTJ1</accession>
    <name>A0A914YTJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2988.t1">
        <property type="protein sequence ID" value="PSU_v2.g2988.t1"/>
        <property type="gene ID" value="PSU_v2.g2988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2988.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21840" checksum="836F0912D8D8222B" modified="2023-02-22" version="1">MALPDDYQEVMEMMDDDFEARINQLQKGTQWKELKPKRISTPKRSSKPSSESSKQRDTDFSCEASSEESDSGKDKSRQSLYHPAALPPIPPQQRKRRFKKAVRNYHAATHGSTTHHMKNSLTHIEMDESIYIFPENPMSQSLSASFFGSKTPFSSSKRKHEKQRIHRSASDYVNLSWNLESKQFFYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTK2</accession>
    <name>A0A914YTK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2997.t1">
        <property type="protein sequence ID" value="PSU_v2.g2997.t1"/>
        <property type="gene ID" value="PSU_v2.g2997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2997.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14647" checksum="8E9F11BEE534CEFF" modified="2023-02-22" version="1">MFPKKNRHIPTSDNNRDEPESSRSSYRTGPESSRNNYGRSNDISNSWRSSNDYHRDDRYNNRDHDRRRRTPPRSSSNGYGFERRDTYGEKCERSANDAALERTKATERELKKLRQQMELDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUF2</accession>
    <name>A0A914YUF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21107.t1">
        <property type="protein sequence ID" value="PSU_v2.g21107.t1"/>
        <property type="gene ID" value="PSU_v2.g21107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF72">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21107.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="55994" checksum="51AE3F713C468F80" modified="2023-02-22" version="1">MAMICMVNRTAVDALNEKTLSLTPAPTLLNNNESQLLKIIENKGQIDECEIEDLGFIKSRQAMKKAQLAKHYNGNLVIKKPDQALIFTSFYAGGLAIVIPGSYLCDRFGAKNVVLIGAVVNVIGTFLTPFVASTMHAYALVALRFIMGCGQGILVPCMNVLIAHWFPLAEKSTAIAISTTGNQVSVIVAMFLTAELCQINLFGGWPLAFHSYGIIGLGFCIFWVVYVYNSPSKAKNISTDEVLYIQECSHNVGGKKIGANEVPWKAIFTSPTVWATALNSFSQNFMTVGTITYIPSYYQTVLRMDLSANGLMSAFPFIFQLITKIILASSADWLRKNKVMSHNSVTKIYNLIASFGSGICYFLLTFCDCRSSTWAIILVILAIGLSSGFIPGYNTSMVCIAPRYTSSVASFCRLLGQIAAVASPYMIGYIVQKGTKEEWKIAFYVMTIVLFICGAAFQFFGSVTVQEWAKAPSPPTSDNRLQPSDGSANAMLLPEKGLKSIESEKNDIKIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV70</accession>
    <name>A0A914YV70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21404.t1">
        <property type="protein sequence ID" value="PSU_v2.g21404.t1"/>
        <property type="gene ID" value="PSU_v2.g21404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21404.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23818" checksum="D23B5854ED9FCD9C" modified="2023-02-22" version="1">MFGIFLIMFSPIFIRKVLQHPYLAVGSFAALPTLLQFFVKLFSGQFSDKLAKPENFKVKLFNSIAFFGMALFFILLAILASYENQIMSVIFVIASATILGFNCGGFYKASTLVSRQYSHFVNAHLQFFASLALLLVPFIIYAIAPNNTASEWSIIFYIFAATLIITNIIFVALGSGEPAAFTGNLLPENDLVANNGEQMKPIIKDSSAPVQHHVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVN3</accession>
    <name>A0A914YVN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVN3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4639.t1">
        <property type="protein sequence ID" value="PSU_v2.g4639.t1"/>
        <property type="gene ID" value="PSU_v2.g4639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NR LBD" evidence="8">
        <location>
            <begin position="70"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4639.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33984" checksum="FD21E8BD45E79BDA" modified="2023-02-22" version="1">MEPATVSHFNVDVCTGCRAFFRRSKEQLYNQKLDNPTQKISTTSSSTTVSLITNEPLTTILSFPSNTTTPADSVMEHFLHFRRKITYDRLQTYYGKNKIGEDVFVDCNHTVGSGLRESHLIVEILSRSPVFDGIPAADQRILFGDYSVVWTVHEQVLSTVRNGGHLTKKIFFPNGTNLRLTEEIAFKYWAPLFATIKDKRPVIIEMVGRFLLNLASYTTLEISRFMVSASMNEEELAAFTALLFLRPEILSAVSPESRTILSQRRHQLLHNLSNYLISTGQKVDERMSKIILLISEMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ34</accession>
    <name>A0A914YZ34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ34"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4894.t1">
        <property type="protein sequence ID" value="PSU_v2.g4894.t1"/>
        <property type="gene ID" value="PSU_v2.g4894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4894.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13675" checksum="F5B628E72E7F4187" modified="2023-02-22" version="1">MISHNRICGIHVKTLSKFFSILGSFGSLFVFAVAKLLSVLSFNIFLLLLSNFIAYIFALNGTLKEKSFQLRAAQLFLLPNIGMALYILNLAKKAMIFQFMAEWEFSLDEKKDKKGFICYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZH4</accession>
    <name>A0A914YZH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZH4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5030.t1">
        <property type="protein sequence ID" value="PSU_v2.g5030.t1"/>
        <property type="gene ID" value="PSU_v2.g5030"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5030.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="24677" checksum="BAEFEDE5A3E96E78" modified="2023-02-22" version="1">MSSSSVLRPVKGLVSLVTGGASGIGRGTAHYLSKQGAKVAIVDLPKSDGEKVAKEFGENVIFCPADITSEKDVSNALDTIKDKFGRLDSVVNCAGIAYAFKLYSASKKRIEPMDRIRHTLEVNVLGTFNVIRLSIPVMMEKEKDDYKQRGVIINTASVAAFDGQVGQTAYSASKGAIAAITLPLARDLADDGIRVLTIAPGLFDTPLLSSLPDKFCRQCKKGEQKALLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0C8</accession>
    <name>A0A914Z0C8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0C8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5625.t1">
        <property type="protein sequence ID" value="PSU_v2.g5625.t1"/>
        <property type="gene ID" value="PSU_v2.g5625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5625.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22976" checksum="52680D9C02154A17" modified="2023-02-22" version="1">MSRSAIIERLQQENRELKSRESTWTKREEEWAKEKEKLELEIQKLCESNESLQSQVNSYLNRSARRGFASMLEHDSEVPVPGKIDFDDDSSVLTNAQRKHRRRTQFISKPVHQPSGVELQKRLVDTEKALEEEERIRSESELEVNKLHQVIAERDDRIRELEHMEKEKNKQINNYKEKIAEMVEKVADQKQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0G8</accession>
    <name>A0A914Z0G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0G8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6222.t1">
        <property type="protein sequence ID" value="PSU_v2.g6222.t1"/>
        <property type="gene ID" value="PSU_v2.g6222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6222.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15760" checksum="7B8C954AEC18DC6F" modified="2023-02-22" version="1">MEVVDTDVYEVVAAVEILVVVKNKNLYVVVAAVVVEEVVGRQLGVAYNVDIRLENLVHDSRNNNLLDVAAAAVGVEKLVENILIAAVVYVYVVAVDDNLIEQLQVLDNNVVAAVVDVVVVVVVAVVVVVEVMGDVEQHHQNLKDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z124</accession>
    <name>A0A914Z124_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z124"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6063.t1">
        <property type="protein sequence ID" value="PSU_v2.g6063.t1"/>
        <property type="gene ID" value="PSU_v2.g6063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6063.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9325" checksum="407E847B027DA56C" modified="2023-02-22" version="1">MQQQQQQQQQQSQSQLTHQQSTTTTYGYGPNSQQPQQQPSMTGYTNNIQGSATNLTQPLQGALGNVVTSTAGSIAGGFNKLINRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z126</accession>
    <name>A0A914Z126_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z126"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3977.t1">
        <property type="protein sequence ID" value="PSU_v2.g3977.t1"/>
        <property type="gene ID" value="PSU_v2.g3977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3977.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16245" checksum="F09B9289E487992A" modified="2023-02-22" version="1">MDLNAGFHDLIHALKWIKKEITTFGGDSERVTVMGHSGGGGMTKTLAMSPKAKHMINQMIAMSQSSDYSLVKDKNEAASRAAAQEVGCANFDPSDKKWDSLKVVEKVIKCLRTKSGKELTEAQPKIEEKGYQFRYAAQDSGENAVSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z185</accession>
    <name>A0A914Z185_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z185"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5657.t1">
        <property type="protein sequence ID" value="PSU_v2.g5657.t1"/>
        <property type="gene ID" value="PSU_v2.g5657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5657.t1"/>
        </source>
    </evidence>
    <sequence length="437" mass="48692" checksum="64E8827C1A54C42A" modified="2023-02-22" version="1">MEKPIFNVTCDKKAISLKIGDDEGDQIIQNDDFNSSEAIVSSANSASILFPRIEFNLELVPSHDTVDDSKMFETLSDHDVGYGQSYFMNISFKSENDKAEYGDKFRVTHCVAEADDIAVELVDANGCSINKKLITDFVYKNGYATAKIPSMFRFPNSKTMKFECKLSICQEIQLCRASCDRKMDDPIAEVEDAEMIAQLLGMDDESVQTAVTGPMQSFVEKSTKSTSTIVHVLDRREIPLRNDVGIMKSGNGIFKTECVAPEEIKLLYAILFGLALALALSLVLNICCCLCCRKRKFKKEQRQKPYFVQNECWITGNPAADLTKDVNQVAALTKYLDERRPSVGSYATVKQRFSARPLSQIVPPLQYMEMQESSTTFRPNSHASPPQPAHHSVYELPSQQMSTFRQSLSADSSSGTSTWSPGRSSQVDTNQEASSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1X1</accession>
    <name>A0A914Z1X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1X1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6101.t1">
        <property type="protein sequence ID" value="PSU_v2.g6101.t1"/>
        <property type="gene ID" value="PSU_v2.g6101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF27">
        <property type="entry name" value="PROTEIN CBG26503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6101.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32739" checksum="9E29B02C3388FB7D" modified="2023-02-22" version="1">MEIAPNTTGSDETTKHAQKLQAYIYRAFNGKEIQDYCLGILQVLNKSTNVSFDTLKKLVDDLGADFADTNKLWKDFLLSIKNAISDQASTQLKFNHLLKQAKRGIVALQEDWDALSDSEKADLCQIRSFFPTVTQLIKECAQYFGERASSLHMFYPKWKAYAEQHGIKHYRNPDLKGHRFNIIFTIANSIYYLKDDLLKFIEFLSTSSVKLDHIKTFLRDLLILNHLHILAMLDVAVVGPLLRLIENTEAFGDIGKHDLSILVYLNRVKNEPLILFSGELPVFQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3E2</accession>
    <name>A0A914Z3E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3E2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6411.t1">
        <property type="protein sequence ID" value="PSU_v2.g6411.t1"/>
        <property type="gene ID" value="PSU_v2.g6411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6411.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19400" checksum="5A85919EEB7D5F7A" modified="2023-02-22" version="1">MKINNSETEEFPPNLDIFNSTSAVEDSEEEEPPQLECEIKEKMAVTRSQNNFSRSDNPLQTISKSLRKAPKKRGNDLKSENFPLITKFEEVDFDAPPALDLYGDKQTQFRASSTSSGISSIGEFHSPPSCSPLAPINGNFTRSKPVVKEPTAPRNVTKRKSKTPPTSEKSYSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z448</accession>
    <name>A0A914Z448_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z448"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7474.t1">
        <property type="protein sequence ID" value="PSU_v2.g7474.t1"/>
        <property type="gene ID" value="PSU_v2.g7474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7474.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="10174" checksum="B2CBA3B64E59B9BF" modified="2023-02-22" version="1">MNFFRIFAEYNPHIVLFVDDSSCIVQFRQSRLTAKMLIGMTKKLKRIRKAKKIEEEGEILDSDGEEEDGQIKNEDGEILQIVNKVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4H5</accession>
    <name>A0A914Z4H5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Superoxide dismutase</fullName>
            <ecNumber evidence="6 13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="6 13"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z4H5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5149.t1">
        <property type="protein sequence ID" value="PSU_v2.g5149.t1"/>
        <property type="gene ID" value="PSU_v2.g5149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000003">
        <property type="entry name" value="Superoxide dismutase [Mn], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="109"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5149.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24778" checksum="757060A897496665" modified="2023-02-22" version="1">MIGKILNKTVPSGRCLVSTRYKHVLPDLPYDYNALEPVISAEIMQLHHQKHHATYVNNLNIAEEKSLDAIAKGDIREAVKLQPALKFNGGGHINHSIFWTNLSPHGGEPSGELLNQIKADFGSLENLQKQLSTSSISVQGSGWGWLGYCKDQKKLKISTCQNQDPLEPTTGLVPLFGIDVWEHAYYLQYKNVRPDYVHAIWKICNWKNVDERYQSAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4Q1</accession>
    <name>A0A914Z4Q1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4Q1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7666.t1">
        <property type="protein sequence ID" value="PSU_v2.g7666.t1"/>
        <property type="gene ID" value="PSU_v2.g7666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04111">
        <property type="entry name" value="Rab39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000358">
        <property type="entry name" value="RAB39B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041818">
        <property type="entry name" value="Rab39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7666.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25670" checksum="A0B9ADE5A118BBCE" modified="2023-02-22" version="1">MMDVSADFGPLFHYQYRIILIGDSTVGKSSLLRYFTEGRHAEISDPTVGVDFYARMIEVKPGVRVKLQLWDTAGQEKFKSITRSYYRNSVGVIVVYDITNRKTFDHVTEWLTEAEANVSGPDPGACVFQLIGHKADRDKDREVLYEEGEYFAKYHKCKFIETSAFSGDNVNEAFYMIAREINARLESGALKLQDGWDGIKSGTMRSQSINLSEYSGDEEQNSSSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4Y0</accession>
    <name>A0A914Z4Y0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">XPA C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4Y0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7743.t1">
        <property type="protein sequence ID" value="PSU_v2.g7743.t1"/>
        <property type="gene ID" value="PSU_v2.g7743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21076">
        <property type="entry name" value="DBD_XPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022652">
        <property type="entry name" value="Znf_XPA_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01286">
        <property type="entry name" value="XPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="10">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7743.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="28092" checksum="69DEDC69A5FD6F8F" modified="2023-02-22" version="1">MSKRKQGNDDIPIVEKLYRENQISYTSAGGFGRADDEREERRERITEAIKSRRDRAYQHVPIPDDCQECEAPLGESELWDRFNFPVCSACRDREVRHKLIHRTEAKERYLLKDCDLDLRKPPLRFISKKNPHNPRYGDMKLYLLPQLEARALEVHGSLEKLEEAKELREAKRESVNERRFEKKIKTMRKDMRLAEKPMVLKKQGHSHTFGPEVYNEKNDTYSKACTECDFVTTFEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z512</accession>
    <name>A0A914Z512_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z512"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6985.t1">
        <property type="protein sequence ID" value="PSU_v2.g6985.t1"/>
        <property type="gene ID" value="PSU_v2.g6985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036903758" evidence="7">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6985.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13238" checksum="1280084AA9D481CE" modified="2023-02-22" version="1">MVFAVIICAISLSFFDPTLADHLSSFKLSTTLVGLMFLLCGGIYTATAPLWGILIDRWHCTNALMVFGSTATIFSMLLIGPSPIFNFEKNLVLIGISLAILGVAAGALYIPTFQNCLDAVKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5J1</accession>
    <name>A0A914Z5J1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5J1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7224.t1">
        <property type="protein sequence ID" value="PSU_v2.g7224.t1"/>
        <property type="gene ID" value="PSU_v2.g7224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7224.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17076" checksum="3CB1DF2710AC2D0E" modified="2023-02-22" version="1">MKPMVFLPNLKFKRILRQPQTSYDEKVQQVQALILTLSPDRQQIYNQFMGQQQQQQQQQQSSTSLPPPSPQLLYRQPTRSPSRMPQQSLSNNNKNNNDGFSKITRILQDESIPENERWKQIVGIYGEIEPRVKSENPFAFDEGLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6G0</accession>
    <name>A0A914Z6G0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6G0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g752.t1">
        <property type="protein sequence ID" value="PSU_v2.g752.t1"/>
        <property type="gene ID" value="PSU_v2.g752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF73">
        <property type="entry name" value="V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="804"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g752.t1"/>
        </source>
    </evidence>
    <sequence length="874" mass="100359" checksum="05ABDEE0A4DE0B75" modified="2023-02-22" version="1">MGSLYRSEEMRFCQMIVEKDAAFNCVAEIGKRPYVQFKDLNADVNSFQRMFVRDIRRFAEMERKLRFLEEQIKKEKITIHSVIDKNYDAMSHHDINQLETTLADLERDVMNMNETEYQMKKNFLDLKEWEAVLEKTDLFFQGGIDDEALQEIDQANENETGISRGDKDPMSFSVGVIRTDRINAFERVLWRATHRTAFLRHSPIEDELEDPDTGDKVSKCVFIIFHNGERLKNIIIKICDGFKAKLYPKCPKTSKDRHAAAIQVRTQITDLRTVMAQTHEHSFKVLNATAANIRAWTKQVRIHKSIYNTMNYFTFDGIGKFFVAECWIPLRDIDNVRKALEVAVEKNGSTVKPVLNVLHTDEEPPTYNRTNKFTAVFQGIVDSYGIASYLEVNPAPYTIITFPFIFACMFGDFGHGVLMFLCGLYLVLREKNLISRQIKDEIFGMFFGGRYIILLMGLFSIHAGFLYNDGFAKSFNVFTSSWRNPYNHSFLLEMENSSSPGKEAQLTFAPEDAFMHSDGPYAFGMDPIWNIAENRLNFFNSMKMKLSVILGITQMTFGVFLSLQNYRFFKSKIDIYTVFIPQLLFLSCIFIYLCLQIVMKWIFFWTVPDTIFGFRYPGSHCAPSLLIGLINMFMFKERPAGFVNANNTQIDQCYLSQWYPGQSLIEAILVIIAVICIPIMLFGKPMYILREQRKQKKAVGDNMSVRINMHTDETEVINNGNGVRTDAHPENEKAATSAGHGGHQDETFGDIMVHQSIHTIEYVLGCVSHTASYLRLWALSLAHAQLSEVLWHMVLGNAFGSDGILGVIILYFIFFFFAVLTFSILVLMEGLSAFLHALRLHWVEFQSKFYLGLGYPFVPFSFNQILTEASATDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6J0</accession>
    <name>A0A914Z6J0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z6J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5866.t1">
        <property type="protein sequence ID" value="PSU_v2.g5866.t1"/>
        <property type="gene ID" value="PSU_v2.g5866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="186"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="263"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5866.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38164" checksum="65E9A715A6F09F59" modified="2023-02-22" version="1">MTNWDHTEEEEENGAECSRTKDFADAERICRHLNIELHSVNFVKEYWNEVFLPLIESYKQGKAVVPDVGCNSMIKFGTFYKFAFENLKADAVATGHYARTSFGDFLESKIDNQKCRLIRAKDSIKDQTYFLANVSEDKLQNTMFPVGSLLKSQVQQIADQEGLNFLLNKKESMGICFVGKRKSFPQFLTKYIEPQNGDIILASSGKAIGNHSGVFNFTLGKRISVPIENYQSHDGLFVSKIDPINQIVYVCEGSQHPSLFARSFQISSPFWISSPTKENLEFALQRNQPLLECKLMNNLVIPKRPVRAAALGQMCVFYDGETCMGGGEIAKIISTLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z717</accession>
    <name>A0A914Z717_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z717"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6041.t1">
        <property type="protein sequence ID" value="PSU_v2.g6041.t1"/>
        <property type="gene ID" value="PSU_v2.g6041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038022729" evidence="1">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6041.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24322" checksum="FFB5118179934D65" modified="2023-02-22" version="1">MKIAILWVLLSVWIIGVLANGTRADQIDASKLPQNDLILISTIDGYLIAIDSETGQQKWRFKEGPLINSPRDALSGLTFIPNPRNGQLYSLEDGDLGKLPFTIPEAVKGSPGRTKNGILYSGDKKDVWISINIQTGTKLEFLPPPAEKFLDDVTDDQCIVHAFIGRTEYHLKIMDSKSPDREWNVSFTDYSSHLLPRWFFYYNFIFCNKSFTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7J5</accession>
    <name>A0A914Z7J5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7J5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7846.t1">
        <property type="protein sequence ID" value="PSU_v2.g7846.t1"/>
        <property type="gene ID" value="PSU_v2.g7846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7846.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13455" checksum="45288BBCD1C171F6" modified="2023-02-22" version="1">MVAINSFLRIFIYFFCNPQFRYQIITNFRLLFNKTKSVVQCEENCTPSNENSSNSAVAAAEVMDSPIIFKDVESVQLHSSPDENGARRNSRKGQQTRADRGSVTFDTSTLIKIGDTCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8M8</accession>
    <name>A0A914Z8M8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8M8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8686.t1">
        <property type="protein sequence ID" value="PSU_v2.g8686.t1"/>
        <property type="gene ID" value="PSU_v2.g8686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8686.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33090" checksum="FA968D515B4AEAC5" modified="2023-02-22" version="1">MVEQVTWVDRVRVKATLKHDIGRTALAEFFGTLVLVLIITSVVAQNVLPKAGLGNALIGVNVGVACGIAFGIALCIRISGGHINPAVTLAFLVLGAIRPLKAIAYMFAQVAGAFVGAMLTYFLYNDAINVFDAGTRRVEGLKATAHIFASYPGAHLGWAGGLFDQIIGTAVFVLIIVHTVDRRNAYPMWVRPFIMGVGFLMIGTAFAFNAGYPLNPARDFGPRLFTLVWGWGSKTFSFNDFGWFWIPIVGPLIGGVLGALAYNFIFGFHTPIEDQYEVVATHELKPISEKIVTHTHTEEHTALNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8Y3</accession>
    <name>A0A914Z8Y3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">limulus clotting factor C</fullName>
            <ecNumber evidence="9">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z8Y3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6705.t1">
        <property type="protein sequence ID" value="PSU_v2.g6705.t1"/>
        <property type="gene ID" value="PSU_v2.g6705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037563148" description="limulus clotting factor C" evidence="11">
        <location>
            <begin position="17"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="37"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6705.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30623" checksum="B3A888D2A45FC946" modified="2023-02-22" version="1">MLNLFLLGFCVGTSLAALQDCGKTPISPDITKAANKIVGGEPAKPYSWPWQVDLCKVDDGDDKCNHVCGGSVIDEQWILSASHCKILTDVIPGKWFVKVGTYDYRDLDEPGEKIFNVSQVFTHPNYNNPYADSNDIALFKIDGKINFTKHIQPVCVPRNVSDIIHNGKSAYVTGWGTTSEGGEFSFKLKQVQVPFLDMSQCIKEYPGGIDDTMECAGKEGLDSCQGDSGGPLVTKHSDGRWFQAGIVSFGKGCAEEGFAGVYSSPSANCDFMASIIGYDICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAU0</accession>
    <name>A0A914ZAU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7372.t1">
        <property type="protein sequence ID" value="PSU_v2.g7372.t1"/>
        <property type="gene ID" value="PSU_v2.g7372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7372.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36806" checksum="01E10E9D1E743CCC" modified="2023-02-22" version="1">MTSKAGPPPPAAPVIPSEETEKNDKLPASGEIIPTKHHKYEAIKLLGKGGFGAVFLVKREDGESFAMKCESYDVKKQVLSMDCKVLRGTFLIQSPHFCSVLDRGKAIDRFRFLIMKLVGKNLWDLRIEREPPKFSLNTSLKAAEQCLMAIQDLHTVGFLHRDIKPGNFAVGRPETNEFHTVFMLDFGLCRKFIGETQTKDLRMPRTSAPFRGTTRYASLAALKQIEQSRKDDIEAWLYMVAEWTVGALPWRRLKGQDKEEVLRWKEDIRTGDAHDEFMTGLPRREFDTIMSYVDSLEYHSIPDYDHVHYLLQHACKVILYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB43</accession>
    <name>A0A914ZB43_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal biogenesis factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxisomal assembly protein PEX3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PEX19.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB43"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9137.t1">
        <property type="protein sequence ID" value="PSU_v2.g9137.t1"/>
        <property type="gene ID" value="PSU_v2.g9137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9137.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31536" checksum="A9A06751532FC289" modified="2023-02-22" version="1">MSSIWEFVKRHRGKILASGAFVGSIYTAKKVYDSEYVKEYIQSPSHQEHEAQLSQARRHFIFDAHQQSCDKNLVESISDIKAILKSRYPVEILVESLKDSDEISNEQKIQIWEDIKHKSISRIVSTSVALSIIIIATKIQKSILCSEMCKIVEETRQKQTSMTTHGIKNYISSFIWGNDDKVKPEYGTQFANPKVQQVFVNCIQFLTTSGLNQIFTKIESITEECLNNFSLTKKITVSEFEILIHQILDKFEKEAGAKNYCDYIVPVTNVRVNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB49</accession>
    <name>A0A914ZB49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB49"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7477.t1">
        <property type="protein sequence ID" value="PSU_v2.g7477.t1"/>
        <property type="gene ID" value="PSU_v2.g7477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7477.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15293" checksum="06F3958022D8498C" modified="2023-02-22" version="1">MKDESKVGKQNGRNVVLNGFSENINLTLKDSTLTFKLCTPCSGTIQICYDSISPNSNLQGSCDPSQCELKINIKKTAVTFNSDTSQMDVGTICDYLRIQNTETKFNTISAIQTCPPKIVDGIIHLFVTKAECQVEVVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB89</accession>
    <name>A0A914ZB89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB89"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9185.t1">
        <property type="protein sequence ID" value="PSU_v2.g9185.t1"/>
        <property type="gene ID" value="PSU_v2.g9185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9185.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29045" checksum="80D76C5D741BF110" modified="2023-02-22" version="1">MEECIYKRQVTKDSVAMRVVDEAQIQRHFMSRDLEELYTLSYKAYNESDPPLNAPPRDRMAWEEYNRAKSNPHADQIMQNQMLTASILQSNQPTDPLSLTSTLSALLAQITNQQRNIPDGIPQTQSSQNCLINGVPVDPALSKLIGTDNMFQVSIINGLNPQQATYVTYVKLILHILIHKLPQHLRGGINEMGTHITELLQANAAPQEKTRQVLNLFQSLRQVFRNDLSTSNLLDHYCRVSTWLCPQRVVIPKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBL1</accession>
    <name>A0A914ZBL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9135.t1">
        <property type="protein sequence ID" value="PSU_v2.g9135.t1"/>
        <property type="gene ID" value="PSU_v2.g9135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9135.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17645" checksum="1126D4FDBB001710" modified="2023-02-22" version="1">MQRVQKFNKVLKENECEFINSTFLQLNIPNSQGYCSNNQIYDAKIETNTTIFCKYSCSNTSKLEFLRQQIFNNQFCNCGKCATVVNSRATSNLSNHLQIDIFLQPSLYARINFTDVKAISSHKNDCPSFISTTVDYFSTNNTNTNVARFSKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBP8</accession>
    <name>A0A914ZBP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g9742.t1">
        <property type="protein sequence ID" value="PSU_v2.g9742.t1"/>
        <property type="gene ID" value="PSU_v2.g9742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9742.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19801" checksum="F3DB4BBD4298DF45" modified="2023-02-22" version="1">MAADTGSLNRLPKICGNESWVREIALTARRFDETEALQHDLVSKVYDNREDMMKGVEKMAQTIAAKSPVAIQGTKIVLNYSRDHSIQDSLNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBQ8</accession>
    <name>A0A914ZBQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9179.t1">
        <property type="protein sequence ID" value="PSU_v2.g9179.t1"/>
        <property type="gene ID" value="PSU_v2.g9179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9179.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="20243" checksum="925E644308CADDA8" modified="2023-02-22" version="1">MDTNIQQQKCCCNCQQINTWRILLRNCTHIICIFCGIEYIRQCIQEKDKARIKCPKKSCRIRIHENDIKALLDSDNRGLDIFLPQPQREWLQFKHDKDGIGYALGAPKFAKQCPLCMVRKFLKKYTHCSTLKPRVKAKRFNVFMSIFWQNVYSTPKKSKKKRVFVFVIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDF5</accession>
    <name>A0A914ZDF5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDF5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9704.t1">
        <property type="protein sequence ID" value="PSU_v2.g9704.t1"/>
        <property type="gene ID" value="PSU_v2.g9704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9704.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20432" checksum="B5A716E071036841" modified="2023-02-22" version="1">MEVRVSHEEMIKKRLNFVIDEHIGQTGVLKIIPSNEFVEIMEKSLNEIEKYSKLASSGSSAHYQLSKIAPRLYATVETGQEQVSQSIYQKFDPQNSSGHLQPTSSDSQVFDIVECFSKISLDDRSTLSAWHKTIVMDSYLKRLQSNGMNIPLGLDMSELETPQKLSISSCLRKSVNNTVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDV6</accession>
    <name>A0A914ZDV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDV6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9859.t1">
        <property type="protein sequence ID" value="PSU_v2.g9859.t1"/>
        <property type="gene ID" value="PSU_v2.g9859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9859.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9744" checksum="7781B76858CB0C75" modified="2023-02-22" version="1">MFEEALRVAEIDLKTFISLGNELENDGTKTPPPKCLFFSNTARCASTLFGAMLQHNGHSIVIGEHPALSILSSGLKDQYWSEKVINYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZF22</accession>
    <name>A0A914ZF22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZF22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8881.t1">
        <property type="protein sequence ID" value="PSU_v2.g8881.t1"/>
        <property type="gene ID" value="PSU_v2.g8881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8881.t1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46367" checksum="8FF66A82303EEB55" modified="2023-02-22" version="1">MTSTYSASLDSLPVELIENIVNNVSARALWKIIRPLNKSFYSAICSRDYWLRRIKNTNNIDLLPRIRNQQDLHSLVKLSVLSEENIQRFDENDCLTDYLICTRHISTPDAFHSQYIDGRRMLFTGARDHKIVIWDLQKAAEEKNLQNGIKFEFNSAHDGWIWAITAFEERSFFTSSWDQKIKCWRYGESAVMESCYNAIKAVVALATVDRIIIGSVYGGQLHFCDFRQQNKLIHELNLQSTTAIGIYADPKGYGLVAGTESGRLFLYDRRFLANPVKKTKIFDGIRTFQYSNGTQMAACSRTQTIIFDPSTLNTELDFTAATDTSPYYCIPTESGYFCSDNFDITYYSGGQNPRKITQTTFSNRISTLRYFDGDLIAGLGEGSIQVWPKEQLLNGRLNVDSVDNSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZF91</accession>
    <name>A0A914ZF91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleotide-sugar transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZF91"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8946.t1">
        <property type="protein sequence ID" value="PSU_v2.g8946.t1"/>
        <property type="gene ID" value="PSU_v2.g8946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8946.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21130" checksum="ABE3D79699282FFA" modified="2023-02-22" version="1">MSNHQSPTTIEEKYSDQFIGLTTVLAMCWMSAFAGVYLEGVFKNSTCDIWLQNIRLSVITLPFAILTVGHDKELIQENGFFYGWNWLVWLIANSSAISGIVVAVVMKYADNIKKSYCQSIALGGTALLSVASGDVQATFLLFSGVSLVILSVFLYSLYPPSKVKPRNVVITINLKPPLQTRTELLSIKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFY7</accession>
    <name>A0A914ZFY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZFY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9194.t1">
        <property type="protein sequence ID" value="PSU_v2.g9194.t1"/>
        <property type="gene ID" value="PSU_v2.g9194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9194.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40193" checksum="B3DD1D64EB16BF30" modified="2023-02-22" version="1">MSDRIQINLQRTIKEVQKIQEEYNDLLIHNPPPWSSLIKIKMETKIQRIKQSHAFILQALDKWEEVAKKTKDPDEKQLQYQSYDEWRDNDDNSKLLNDLTEIVMEGGKYLQLETEDDNSSIISNSTDFTPKNEIIATMPPLNLPKFNGDYLKWNTFWQRFEHAVHNRPFPKIEKLITLMGLLEGRASEEIEGFQVSEENYETIVDILINRFGKKQLIIMQLQSQLRAVEAAKPNPESLRSTVNIICNMCRQLENLGVDINNDSVKMDIIEKLPNREKDELKWFLISSPETATIEQIMKRMKDMALKAELSSKNQKEVFVETKTSSFQPPNNDPSSFSLRSNTDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZG84</accession>
    <name>A0A914ZG84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RED-like N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZG84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9298.t1">
        <property type="protein sequence ID" value="PSU_v2.g9298.t1"/>
        <property type="gene ID" value="PSU_v2.g9298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="63"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9298.t1"/>
        </source>
    </evidence>
    <sequence length="511" mass="59496" checksum="433DD0160E8298CC" modified="2023-02-22" version="1">MASLKNDDFRKLLTTASKSRPSETPSNQSSGAASNRRNDKKPQSGGKKKFHNKKKDEEEKTDVDKIFDESQQNLTEIMKGYRDRAAERRKADTNKESDEAALRLMIHGIMPTDLEKNRGELTIEQSKLLGGDIEHTHMVKGLDYALLEKIKTEKEESDEEEDEDKDAPAASLPPEKVAKNPMVRRTLRTIFHTVFPKRNEHFAPGRMAYVCDFENQDSDVPSTLLRSLEETPKENPSVKTDKLILEHLTNILPYLRDKKRQKKKKNRVDDEEEAKALGDIKIFDDAGDYDTRVKPLKQDRNRSDRDSHKDEKQSYFSERDDKRNRRGGDDDGNDRRRESDRYRKRDEDSRRRRDRSPDRRDREREKDRHHREKSSERSGDKESRDEPRKSSIFDKHLSSDSRKRSIVSPSKVEAKSTKKIKQDEAYGEYYTEDMDFVETIASDDDDDQALAMAKSRMFHELGTDATDSKGKKSMDKKKPNQSKADVARKFDNEMKKIDEIWAKKKDAKVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XPY7</accession>
    <name>A0A914XPY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XPY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10081.t1">
        <property type="protein sequence ID" value="PSU_v2.g10081.t1"/>
        <property type="gene ID" value="PSU_v2.g10081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10081.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35725" checksum="5FBE49E414FCA0D1" modified="2023-02-22" version="1">MKRQNSIPQPLRPAALNSHHRKCSHDSLQYSDTNTISIPGGLTSLTQQENYNHKNDVLSPILVTDLGNSSCHSLKRVTLTEETAPLPESLSPVSSMHTITFGWASPGTAHFRKISADCESGASTSRPIENNGTEMTEMDIVDEHQTGLFFLRMADGRSLPIYCHQPVGEQADHILHNINARFKEKLRKFIEQDKPQDGENYVWIQSDRNGKSTVLSLRQLENHFNSAQVKRVKWRYSLGTTIYRYSVPIITTKFRLRIMHFLSQNYRCCILFVWCFVILFISVGIVLSVIFGSTPYMNSSLRRNMTTTYILQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XST9</accession>
    <name>A0A914XST9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XST9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10339.t1">
        <property type="protein sequence ID" value="PSU_v2.g10339.t1"/>
        <property type="gene ID" value="PSU_v2.g10339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10339.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16417" checksum="A3A697D6C1A4E11E" modified="2023-02-22" version="1">MVDFIGDINTAYYCIVLLGTVGLLTVFFIRTASVSSNVYITLTIIATVTSFMAIATITIYALGNGWNTPNCADSKIVDFLNRRLIVQSLASLIINVIFIIMCYHLHKKGTKLNGFDGSGSSRRVYSISPPEFVSTFPPPPPYYSTRQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU02</accession>
    <name>A0A914XU02_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914XU02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10008.t1">
        <property type="protein sequence ID" value="PSU_v2.g10008.t1"/>
        <property type="gene ID" value="PSU_v2.g10008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10008.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11214" checksum="2A62DE1B52F267ED" modified="2023-02-22" version="1">MDLHASQIQGFFDIPVDNLIAEPAILRYIQTSLQNGKIVLLVTSIADRLSVDFALIHKERKRANEVEKMTLVGDVKDKIAILIDDLVDTCGTICLAGEKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU08</accession>
    <name>A0A914XU08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Receptor ligand binding region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XU08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10012.t1">
        <property type="protein sequence ID" value="PSU_v2.g10012.t1"/>
        <property type="gene ID" value="PSU_v2.g10012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="33"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10012.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="52893" checksum="6F4CC8BB02A91758" modified="2023-02-22" version="1">MTPRGVSDFDTTLSFKKTAGGITIGMNKLFSEGILPNVNFTFTYFHDQCQEHLSAGGTVQLIKDGDVDVIIGPSCTTSARIAGTIGAFYNFPIFIWSTVLSAEFSDIEKYPTVASTALNTYSIVKALGDLFDFFQWNEFAFFYSVSLSTAVPRCASIQSDIDNYASSKENMTMVYKRSTTNDSYDTLKAALRRMKTNARIIVTCLETPTARRDFLKAATDEKMLNDEYVYVYVQTIQSGFIDTAYGSQPFWVDTSAIPDGRDAELKEAAKKVIILDMEQLPSTFPQFSNDVIKAMYQWPVNCVDPYCPPVGANATKQATFLADTFYMYGIALNRTLTQYPNNQSIIRNGSVMISNSRVSFKGFSGRVVTDENGLRLPILNVFALDNNGNQQVYIILEQKDNTTNNTVIYPQYSSAQNGIWQTRNGVTPLSNPKCDFDGSGCPPSFVQTYLGYVVGGVILILIFITVFVVLICYTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUU6</accession>
    <name>A0A914XUU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUU6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11713.t1">
        <property type="protein sequence ID" value="PSU_v2.g11713.t1"/>
        <property type="gene ID" value="PSU_v2.g11713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11713.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20356" checksum="E7B7D14EFA76049A" modified="2023-02-22" version="1">MASTYITEKFAGPASARGTSYSYTYESKVDDPVVHPVEEYTTSFSEDLEGDIERHSTQTQKVTRVTKITTTRSVRQVPVDPNNIFFDSDGNPVVNGYAVQNSQYPDDGLGIDLSKTYISEHEEYSSPSSSTGRTPSSLPYGRYFSPSAPGMPQVIDIDSQEISLAWLRPDHDGSAGPVVGYRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVL6</accession>
    <name>A0A914XVL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11279.t1">
        <property type="protein sequence ID" value="PSU_v2.g11279.t1"/>
        <property type="gene ID" value="PSU_v2.g11279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11279.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19768" checksum="046DB09D7072E539" modified="2023-02-22" version="1">MRRPTIRYKKWRFCKIAVEPLRILKRLCFSKAENKSRTPKNISNSFGQHEKLSTETIVTIAPKSIEGSTGTLRPITRPQIAPPPPPLPFNSTNTFRPARPPPPVFSKPNRTAPPPPPPSNSKPTLTVCEIPSLPTEEDPIHLRRNEVLWAEYEERISHKFADFGDECASDDEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVU0</accession>
    <name>A0A914XVU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11090.t1">
        <property type="protein sequence ID" value="PSU_v2.g11090.t1"/>
        <property type="gene ID" value="PSU_v2.g11090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11090.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10610" checksum="8AB99390465DC98A" modified="2023-02-22" version="1">MNKSENQYEAEIVKLKQEIQECQQELGKQIVKFARLEKETSVNSSKLDDIDMEEITAKEEELQSKIALLEQQMEEETKKYETELAELSAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW30</accession>
    <name>A0A914XW30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XW30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12140.t1">
        <property type="protein sequence ID" value="PSU_v2.g12140.t1"/>
        <property type="gene ID" value="PSU_v2.g12140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012314">
        <property type="entry name" value="Pept_M12B_GON-ADAMTSs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF306">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08685">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51046">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GON" evidence="6">
        <location>
            <begin position="234"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12140.t1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50038" checksum="944DAA0C9D1687C4" modified="2023-02-22" version="1">MAQRKMVNAGVKKRTIHCKKGRQIIADTECSAFPKPQETEQCESTKCPVYTWKVTPWSKCIDPCKKMNQHRRVYCLNEGGKRAASRMCQNETMPIKTRPCNIDQCPYEWVPGPWSTCSIACGTVSNSFRRIDCKVKRGMRGQNTKLGSEPTVLSRMCMSLKKPEVNKECAMIPCDAEYRWSVLPWGKCSKVCGPGTRRRKTPCLNRLGVRVPKAKCNKDTRPKHRESCFLRNCLPNDCAEIKAQNTITNSIDGNYTVLVAGFRITVYCHLMNNTIPKTFLNIDAESNFGEFYGKRLLYPYTCPYGGKRNDSCACSNDGHVSSGLSRYRRVRVDLHNMKINPHDFTFAQTAYGTPVPYGTAGDCYSASECPQGRFSIDLRGTGLKIVDDLQWMDHGHKSSSKIVRTENNALIRGQCGGFCGECAPDQYKGIIIEIDHKQRPSIGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW70</accession>
    <name>A0A914XW70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTP synthase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11478.t1">
        <property type="protein sequence ID" value="PSU_v2.g11478.t1"/>
        <property type="gene ID" value="PSU_v2.g11478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11478.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25118" checksum="AD7DA2D1BCABF19D" modified="2023-02-22" version="1">MSLCGATKIKIILVTGGDINKGIVAASIAKLVQENGIHITIIKMDSCLNENTTNLKVEKYGEKYVNQDSSTVAVNSGNYERICDQIFTNKNDITYGKMVEYVKNNENGDKTYAPINVVQATIEWIQDIFEHTIDGKNFPKVCLIEYPKMDGADFLKALTQLKYDNPFIHIHCSKIVLGKCDSIQKSVENLQNIEWSPDIIICRSRNPLTEAYKEQNEGKDMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWN2</accession>
    <name>A0A914XWN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12352.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16298" checksum="0023C24D08B7792C" modified="2023-02-22" version="1">MLSRKRTTMAELEPGAKRENDIDPSPKESKHFDENGSVNNFAQQFSNEKYRKRQPIKKKNQTSVTFNWILKPSDVETKDQLSEMDADNNEHIDRSQTYSHISSFKKEPSTPQGQINYYVQYQSNEKQKHYEFKMDESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXF5</accession>
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        <submittedName>
            <fullName evidence="3">Dihydropyrimidine dehydrogenase</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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            <taxon>Panagrolaimus</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Alpha-helical ferredoxin"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
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        <property type="entry name" value="alpha-helical ferredoxin"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10432.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19832" checksum="A57A54EF90EE29AD" modified="2023-02-22" version="1">MICPTSDLCVGGCNLHASEEGAINIGGLQQYAVETFMKMNIKQIVSKEIEASRNDAHKSPIALFGAGPASVSCATFLARLGYTDITIYEKQDYIGGLSSSEIPQFRLPYNVIDFEIQLAKDIGVKIVTGKALHKDDLSLEKLKSDGNKAVFIGIGMPEPKKVGIFKGLELSMDFIHPKIIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZD3</accession>
    <name>A0A914XZD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZD3"/>
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        <property type="protein sequence ID" value="PSU_v2.g12318.t1"/>
        <property type="gene ID" value="PSU_v2.g12318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12318.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18842" checksum="6F36EF12EEFFFF5B" modified="2023-02-22" version="1">MARNLKKEYKKKKGANKDASASPPKPQPMKTSVKGRKQVDGGGEDIMASEPSLLEEVADVSSVALKNIEDKGAVDSPAEIRRKLALRIHKLRDVYPAVIDVSNLGSLIVKNEEGKFLDFEKFTCGLEKSLVDIFRDDNKITVVSDAQEKKVLSITRGEVPLKDEDFLRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZE2</accession>
    <name>A0A914XZE2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="AlphaFoldDB" id="A0A914XZE2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12583.t1">
        <property type="protein sequence ID" value="PSU_v2.g12583.t1"/>
        <property type="gene ID" value="PSU_v2.g12583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12583.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42938" checksum="8C6299DDE720C1D1" modified="2023-02-22" version="1">MFAAEYGDYVSRYLLKKRPLEQIVEEALDFAHCHGLAMRTSENKDRSDICQVAPMALFPSPFPSHLLKQAVDAQDPMTELYFYLAWDHDFLIEAHKDVIKTDVFTRKMVEIYEKVWAEGVPQTKSLVTQRADYMADISKNSNGELKQIEVNNIAVSMGGLAQRVSKWHRKIITELEGKDPGEKVPINQPVDTLGEGLYHAWLAMEDPNGIILVVVEDVNQNQLDQRFIEYHVSALSEGNVKFIRATLSECASRLKLNDKKDLIIDDDKRITLVYFRSGYSPANYSSDSEWDTRLTMERSNAIKCPWIGLQLANTKKVQQILTQPKTVEKYFPEDPDKVQRIRGTFASIWGLEHDDDATPTTRRWEKTLQQTHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZY1</accession>
    <name>A0A914XZY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZY1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12765.t1">
        <property type="protein sequence ID" value="PSU_v2.g12765.t1"/>
        <property type="gene ID" value="PSU_v2.g12765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036802311" evidence="1">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12765.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30926" checksum="716753298373BE02" modified="2023-02-22" version="1">MHLRTVVVAWLLFITLLLDGMKAENNTVDERCDIQKSFNVTPTSKLVKLEKSYYRIDGKEVYINEEPLSLWLKVNPQNMFSLKSSRAWNNRRTVKIFFEPYGNERCLKSFDASVSLKINFLNCECQPFEQNNETFVPFKVWTENGLVAFEVSRYSTHLNFYVSEEEEGKLNTLICLNFDFLESNYYGYDYTDLIMFVSEINENNGTELFEEINQNVTFFTDNGTDYINLVNPITVVWLKIKDSAPEHFLLIETESGEIMQKSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y059</accession>
    <name>A0A914Y059_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNARE associated Golgi protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y059"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12168.t1">
        <property type="protein sequence ID" value="PSU_v2.g12168.t1"/>
        <property type="gene ID" value="PSU_v2.g12168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF20">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="61"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12168.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31171" checksum="406AD2C6E3238878" modified="2023-02-22" version="1">MLISAPGWSESNNGSTSWELPSQFENFTTLAEKFKKYKDEHFAYISTVFVCGYLYKQTFAIPGSFFLNILAGAVFGMTGGFMLCCILTTAGSTLCYLFSEMFGREYVLYYFGERLTYLQQKIDDNSHRLLPFLLFARMFPISPSWLLNIVAPFLNIPLPIFSISAFVGLAPYNFICVQAGCILSDLKSWDDIFSTSTMFKLFSLALLPLAYAVFMRPRPSIKTTSLLSAVAETTKSAHPGGIKRWFAKLTRGNVAPISSENNDSSADLAGLLKPSKVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0W3</accession>
    <name>A0A914Y0W3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y0W3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11485.t1">
        <property type="protein sequence ID" value="PSU_v2.g11485.t1"/>
        <property type="gene ID" value="PSU_v2.g11485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12365">
        <property type="entry name" value="RRM_RNPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034201">
        <property type="entry name" value="RNPS1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="78"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11485.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29250" checksum="D295B00FAED978D7" modified="2023-02-22" version="1">MVRRSRSSSSSSSSSSASSSSGSSTSSATSSSASSARSRGRPARGKSGKGSPRRRSASPKNDKRRSISPSKKEPEPQTRITVKNLSRNVTKEHVMEIFGLYGTIKDARLPTNYHHPNFCRGDATIVYENHDDAEKALRHMDGGQIDGLIISCEWVPPTPPRPVVQRGRSPIRGRSPRRSPRRNFGGRRSRSPFRGGRMRRSRSPVRRSRSPIRGGRSPPRRFRRSPSPGRRSPRRSSPKRKSPPRRGTGGNMIPLGTRRRSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1E7</accession>
    <name>A0A914Y1E7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L24</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1E7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14023.t1">
        <property type="protein sequence ID" value="PSU_v2.g14023.t1"/>
        <property type="gene ID" value="PSU_v2.g14023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14023.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18322" checksum="005320FD4EEA0563" modified="2023-02-22" version="1">MKIETCVYSGYKIYPGHGKRIVRADGKLQIFLNNRCRSAALKLKRNPRDIPWTVLYRRKHKKGVHAEEGAQKKRVKRTVQIASRAIGDVSVEALLAKRNQKPEFRRAQREEAVKAAKDAVRAKKAEKKTAKATKPVDKKAAQAKQTKAAKPVKTAKPMVGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2E9</accession>
    <name>A0A914Y2E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2E9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13414.t1">
        <property type="protein sequence ID" value="PSU_v2.g13414.t1"/>
        <property type="gene ID" value="PSU_v2.g13414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13414.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17753" checksum="83932EF02FC935A3" modified="2023-02-22" version="1">MLANLNVLLNDFVAERLHNISLTNQLETLQDEISSRERSRTPSLHEEGFRTTFNGLPDEEIMSDVMSEPFDDEKDDSSADNDDENGQISKTREVGIPNHREFSIRRHSSSFLSTFLLFFLYLFIFLAIWINLYGALVPSWVYIQVHHDHLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y362</accession>
    <name>A0A914Y362_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoribosylanthranilate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y362"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13672.t1">
        <property type="protein sequence ID" value="PSU_v2.g13672.t1"/>
        <property type="gene ID" value="PSU_v2.g13672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000165">
        <property type="entry name" value="Multifunctional fusion protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894:SF1">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="8">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13672.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16319" checksum="29E7487E786D393F" modified="2023-02-22" version="1">MAAAPLQYVGVFRNHDIADVVDKAKVLSLAAVQLHGNEEQLYIDTLREALPAHVAIWKALSVGETLPAREFQHVDKYVLDNGQGGSGQRFDWSLLNGQSLGNVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y363</accession>
    <name>A0A914Y363_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y363"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13216.t1">
        <property type="protein sequence ID" value="PSU_v2.g13216.t1"/>
        <property type="gene ID" value="PSU_v2.g13216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13216.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17861" checksum="B67484CC46C385B2" modified="2023-02-22" version="1">MIGEVTTRMPMRFNRLIKETTKSSTLNDSKIRLDFCKLPEVDPWDPAIMEYIKPEKDHMLNCERTLFEHSKLVDGQLFMYTNDTFDESILCHYRCIFPDGDHHLNYGNWTKVINETKPECDVIEVECRGKNEVEVFYQYLHAQIYRNTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3J3</accession>
    <name>A0A914Y3J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fructose-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3J3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13344.t1">
        <property type="protein sequence ID" value="PSU_v2.g13344.t1"/>
        <property type="gene ID" value="PSU_v2.g13344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447:SF0">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE 1 CLASS 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13344.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12638" checksum="23DBB4951C6C605A" modified="2023-02-22" version="1">MVTLDKPRLSAAIEEATQLGVKVFALPDGDVAASVLTCWQDNPYDVMYTIGGAPEGVISACAVKALGGDMQAELIDFCQAKGDYTENRQIAEQERKRCKAMGVDVNRDTPVSAVAVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3W2</accession>
    <name>A0A914Y3W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3W2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12444.t1">
        <property type="protein sequence ID" value="PSU_v2.g12444.t1"/>
        <property type="gene ID" value="PSU_v2.g12444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038077472" evidence="2">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12444.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19347" checksum="E43EAE855AF268D1" modified="2023-02-22" version="1">MKIEFLVLLFVVTTLKKIVGQSEYDIVKTPCSTNGTLLNYNIYSDNIAQFFSPNYPKNLIINETTSFCQARFYTIVQNYRIWMALYNGYTQSYNVFDDNNHQFGRDYFDSNDAIASFSSKTESLTYELDTFTNASYDWTAFQGVVIAYGNFYLFLLILIKKALKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y460</accession>
    <name>A0A914Y460_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y460"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14986.t1">
        <property type="protein sequence ID" value="PSU_v2.g14986.t1"/>
        <property type="gene ID" value="PSU_v2.g14986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14986.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19250" checksum="0567D39F23CDCADA" modified="2023-02-22" version="1">MPVPILGNAIAFALDDPPNYFVNWRKQFGDIYTFWAGEMPIVCVNDVKTITEKFVKEGEIFAGRAQITELFEITRHGQQGIIFEEGDPWRTHRRFALRVFRDFGFGKNLMQEKIMDEFAYLMETVKQKDAEGIKDHSIQDYVDLAVGSVINNLLFGFRCSEVSISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4K5</accession>
    <name>A0A914Y4K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4K5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14162.t1">
        <property type="protein sequence ID" value="PSU_v2.g14162.t1"/>
        <property type="gene ID" value="PSU_v2.g14162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14162.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9834" checksum="53D8E7346B465888" modified="2023-02-22" version="1">MQSNEPEHIELFELIEQMLDYEPASRVKLADALKHRYFDRLQPHERVQITDHVNGNGNSLTTTSAAIGIRPNNNSNMTVGDSNANSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6I6</accession>
    <name>A0A914Y6I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6I6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1506.t1">
        <property type="protein sequence ID" value="PSU_v2.g1506.t1"/>
        <property type="gene ID" value="PSU_v2.g1506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1506.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20828" checksum="C830DE765A5278D2" modified="2023-02-22" version="1">MGFQQTNNVEYHPITPIGNEPLQFNINSGQTYLVLSSNYLVTRFKLTKKELGKQVNITNADCVSFIQGFCGTFIKNLRVSFNGKSVYNGNDLYAYNSYLRRRLGLGVSRNQGELEAAGYYEDGLDQLSGSGFEARRSLYENGASFESICTLDCDIFRQKKLLLNQVKVDIEITPHLLLCFIKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7K2</accession>
    <name>A0A914Y7K2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7K2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15252.t1">
        <property type="protein sequence ID" value="PSU_v2.g15252.t1"/>
        <property type="gene ID" value="PSU_v2.g15252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF11">
        <property type="entry name" value="GTP-BINDING PROTEIN GEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15252.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38661" checksum="ADC09F6E878901F5" modified="2023-02-22" version="1">MWQYSPARSQSFRHRTRPPIEIRRNVLEDCSQERRRSTPTVTRRCSLQRTRYEAPRTDVWPEPKQMSEIEERFLRLPDSEDYTRVRQFNIDKKGVVVSRGDSFRRKKNNKADNSPSPFPQSESESPRDTASRSTSISSTAGSGLKVSSSIERSSPGEEEAPSTSQHYKICILGQAGAGKSSLISQFITSEYRNAFADEVEVCDNTVSVAIGGSECELLFIEYDPNNTDQWKHEEVQAYVLMYSIDSKSSFRTITNVMEDLRIERNNTPIILAGNKVDLERKRAIAASEVRTISHQYSVAHFEISVALNHEVNELLIGIVAEIKNAFSNSPLRSDQENSPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7Q2</accession>
    <name>A0A914Y7Q2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y7Q2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15304.t1">
        <property type="protein sequence ID" value="PSU_v2.g15304.t1"/>
        <property type="gene ID" value="PSU_v2.g15304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15304.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36944" checksum="DC248A92222A8583" modified="2023-02-22" version="1">MENLFLPDSGILIPDGLGSEGFEGMMKACKYARENKIPCLSIGHGFQCAVIEFAQNVLGIHANESYKKVLEVVNIKMLENGNPRMGARTITFLTKDSKLYKLYGSKPFIKERNWNRMEINPFFVPSYLSSGLRFVAIGFDENEDGEISDTLQNLMAIAQIHDESDEKDYIKTMKKLCKYSHETHTALRMQAMELKEHPYYVGIQYHAKFGLNPSMPSPSFIGLIQAASREKENFEATNVSSFSNDTVITTKDNDLKITKKDKSSAFAYYYYIKCKNPIEDGIFKISSLERFLKAKLNNLVNDVRADQFKIVITSEKNSQNIISNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7T6</accession>
    <name>A0A914Y7T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7T6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16266.t1">
        <property type="protein sequence ID" value="PSU_v2.g16266.t1"/>
        <property type="gene ID" value="PSU_v2.g16266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16266.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13541" checksum="B93F6065E40B90FB" modified="2023-02-22" version="1">MFERDGNMCKNKNGKQQNGMNSSNGCEFENVIQAFGRNAGILDELSDRSSQVIVDVLDQEEITHEEVEKRCKEICEAEYFHLKNAPIRVEDLPPKISIEDFRQKLYELQKRTDFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7V0</accession>
    <name>A0A914Y7V0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7V0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1628.t1">
        <property type="protein sequence ID" value="PSU_v2.g1628.t1"/>
        <property type="gene ID" value="PSU_v2.g1628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1628.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="10528" checksum="5C42BADFF0AACDCD" modified="2023-02-22" version="1">MIPLTGDSGAATIVGVVLAGGVVVVVVVVVVVVVGGDGGGVVVVVDVVVVVVVVGAVGGLIVDGLDVVDIIGDVKVVIIVVGGELVDVVGTLVSETVGELLLLLLLSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7W9</accession>
    <name>A0A914Y7W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7W9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1537.t1">
        <property type="protein sequence ID" value="PSU_v2.g1537.t1"/>
        <property type="gene ID" value="PSU_v2.g1537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000358">
        <property type="entry name" value="Tau tubulin kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1537.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41822" checksum="9E6555BBE3D85E25" modified="2023-02-22" version="1">MATAAAIKLNVGDKIKDSFTVRKKLGEGACGTVYLVQSCKNAKIWAAMKVEPAQKNKDDEILKMEVFVLKKLQQSKHVCRLLMSGRTSAYSFVVMSLLGKELGDLRRRMPERKMSLSTVLRIAYQSSQAIQDLHQAGFIHRDIKPSNFSCGHAKKDVIYLFDFGLARQIYINDKNGNIKLREPRNKVSFRGTVRYCSLNVHLYREQGRHDDLISMLFMCIELLVRSLPWKGLARKDSGHLKESISDKILFQGCPPSFNEIYVICKKSTYHDTPPYEQIRDLLKKDMKAIKCKMDDPYDWSKNHPPVTESAKSHIKKVDEKVEKESMEDTNTLREIEDSIDTDASEDNTETRGFAKEDTLDNVKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8M4</accession>
    <name>A0A914Y8M4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8M4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g158.t1">
        <property type="protein sequence ID" value="PSU_v2.g158.t1"/>
        <property type="gene ID" value="PSU_v2.g158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037640471" description="Lipase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g158.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46676" checksum="1FD645D6BB0E440A" modified="2023-02-22" version="1">MKFIVFCFLVFVASNFAKSESATPTPFPLDPEAGLQTPGIIKRWGYPVEEHQALTKDGYILTIHRIPYGLHDGLSQNARRPVAFLQHGLEASSSNWISNLPTLSMGYLLADAGFDVWMGNVRGNLYSLNHTKYSVKSHEFWKFTWDEMQEFDLTAMIDTALTKTNHSSLYYVGHSQGTLIMFSKLAEDVAFASKIRKFFALAPVGTVKHIQGLLEVIAKDFYDGFEVLYKLFGEDQFLPDDAFMKAMLKIFCEDSAQEEQSCANMLFLISGPSTGQMNATRVPVFLSDEPGGTSTMNIIHWSQMVRTGKQQKYDYENGLDNLWHYGSVTPPEYNLANINADIHLYWSPCDWLADEQDITEHLLKNINPNSLKESVKLDDFSHTDFTWGSKAKDQVYLPIIATLKKDLAQNGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAI9</accession>
    <name>A0A914YAI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14523.t1">
        <property type="protein sequence ID" value="PSU_v2.g14523.t1"/>
        <property type="gene ID" value="PSU_v2.g14523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14523.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="6432" checksum="D31DE6144B68DB5F" modified="2023-02-22" version="1">MQMPSKKALATAAGVGVGSLGAAAGNPRPIEMNAAGGGTFNDGGGVLSNEKTGRSNTYSTTYQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB70</accession>
    <name>A0A914YB70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YB70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17457.t1">
        <property type="protein sequence ID" value="PSU_v2.g17457.t1"/>
        <property type="gene ID" value="PSU_v2.g17457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17457.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13923" checksum="6D8967BB618D07AD" modified="2023-02-22" version="1">MAVTRDFAKYDNEGNLYIFGRLKDVIKVNEEKIGPSEIENILLSHSKIEDAAVVGIKDNEYGQIPKAFIVKSEKELNEQNIQEFVEEKTPASMHLKGGVEFISEIPKSGGGKISRKDLIKNDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBM1</accession>
    <name>A0A914YBM1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="3">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YBM1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16818.t1">
        <property type="protein sequence ID" value="PSU_v2.g16818.t1"/>
        <property type="gene ID" value="PSU_v2.g16818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11298">
        <property type="entry name" value="O-FucT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16818.t1"/>
        </source>
    </evidence>
    <sequence length="418" mass="49372" checksum="8141B38E2592EB72" modified="2023-02-22" version="1">MITFCYVENEADYITISTNSANVSTAKDRRYLLYEVNFGEGFNLRRDVYMRVAQTVQSLRQKGDNYILVLPPWGNLYHWRDRARRVPWRELFDLKSLNLFVPVIEFEEFLEDNGNVIDHVIYLQHYAEGWNNGQWEEKFDVRKCINADNYYAKDGNMWKGFFYSYDNIKAKNLTCLSIQGEAKTLANAISSMFFDLKTVFIDRAETVLHDSFGNEIYWRIRRSMRYASNLREYAEEYRQEYLDSNFEDDRITYPESWVDEYHQERSAVGGNYIAAHLRRQDFIRSHDKDVPSLEEAAIQLKKICDKLLIKKVFVATDADQEEIDQLSNLLSSHNIKLYSFMPQTLLSDGAISIIDQIIASKARYFIGTHSSTFSYRIREDREIMHFSLESTFNNFCKYSKDIGNKDKCEQPAKWKIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBP8</accession>
    <name>A0A914YBP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribbon-helix-helix protein CopG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBP8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16844.t1">
        <property type="protein sequence ID" value="PSU_v2.g16844.t1"/>
        <property type="gene ID" value="PSU_v2.g16844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16844.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15549" checksum="55DC18FF785BECDC" modified="2023-02-22" version="1">MYYTGHYLTYSHATRRLQAIGEFREWMMAELGMPSSCSAVPTEPAHLIKKSDETHRYGKTQRRQTAEQCKKAGTPQRFAGDSAVADRREQRRLDQAAGLVSFPVKLTQPVIDAVRARATEQGVSTNEVIDRLLAQALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCG2</accession>
    <name>A0A914YCG2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 20">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YCG2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17109.t1">
        <property type="protein sequence ID" value="PSU_v2.g17109.t1"/>
        <property type="gene ID" value="PSU_v2.g17109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17109.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26657" checksum="C4FE44F4A2803726" modified="2023-02-22" version="1">MPVNRPNHADMCVLMGLEMIKTIKQVRVATGVNVNMRIGVHTGSVLCGILGLKKWQFDIWSDDVTLANHMEACGVSGAVHITKKTKDMLMGDYCFVEAKTDDPTILALCEPTYHILPDKATIVERTASIYRNKRRAMDICEDGNAAASRISMKAKMSKMAEFWGAETPFSNLGRERPGEPDETENGDQIRNRRGANYGSMVQSMTLIENNLSNLSSTSLRTMFHCTTGTYEISPLLLCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCK7</accession>
    <name>A0A914YCK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MmgE/PrpD N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17973.t1">
        <property type="protein sequence ID" value="PSU_v2.g17973.t1"/>
        <property type="gene ID" value="PSU_v2.g17973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17973.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="16975" checksum="94D6B99341B89D49" modified="2023-02-22" version="1">MSAQINNIRPEFDREIVDIVDYVMNYEISSKVAYDTAHYCLLDTLGCGLEALEYPACKKLLGPIVPGTVVPNGVRVPGTQFQLDPVQAAFNIGAMIRWLDFNDTWLAAEWGHPSDNLGGILATADWLSRNAVASGKAPAASRWKTPLTASVSTTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD10</accession>
    <name>A0A914YD10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD10"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16629.t1">
        <property type="protein sequence ID" value="PSU_v2.g16629.t1"/>
        <property type="gene ID" value="PSU_v2.g16629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16629.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8381" checksum="E07D2DD62ABDF222" modified="2023-02-22" version="1">MTVEGFFSFNKAIAKMRDHIRDFIVQIRQEAGDDTSDLYLEEKAKEIEKAQSEKNAIPGVLNPHAIKDDEEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD60</accession>
    <name>A0A914YD60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YD60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16681.t1">
        <property type="protein sequence ID" value="PSU_v2.g16681.t1"/>
        <property type="gene ID" value="PSU_v2.g16681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16681.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13836" checksum="A4E3C5F9E3C78C34" modified="2023-02-22" version="1">MIVILGMEKPKINWDRWGELCLTVSAFIDCLVLFAMASAQKLWIMYAGYIIFRVAYQAMITTAQFNIVCRIASNNLGFVFGINTFIALSLQTALTAIVVEKSALGLPIRKQVCSFEEMHLYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEC9</accession>
    <name>A0A914YEC9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914YEC9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17800.t1">
        <property type="protein sequence ID" value="PSU_v2.g17800.t1"/>
        <property type="gene ID" value="PSU_v2.g17800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052468">
        <property type="entry name" value="Dual_spec_MAPK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238:SF2">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE HEMIPTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="36"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17800.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35899" checksum="7492A212C1F317A3" modified="2023-02-22" version="1">MKRPKPQDREYERIKTNSGKLQIGPEQYENVKIEHLRIISELGFGACGNVTQRALNNRILAVKEMKKTSNEEENKRIYMDLQVITCNDCPFIVKSYGYIITFDHVYICMETMAMCLDKLYKNYIKKQNMCIPEWVLGKITVSVVEALRYLKNEHEIIHRDVKPSNILIDLNGNIKLCDFGIAGKLIDSIANTASLGCAAYLSPERMQCAQYDIRADIWSLGITLIELAISEYPYQFNTHFELMCAITGLPAPKLPEHFSLEFKEFVGKCLEKNVEDRPKYKQLGNTKFFQDHRSLDYDVGNWLSNVLEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YED7</accession>
    <name>A0A914YED7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YED7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18626.t1">
        <property type="protein sequence ID" value="PSU_v2.g18626.t1"/>
        <property type="gene ID" value="PSU_v2.g18626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18626.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8717" checksum="3441E0BB7077CCA1" modified="2023-02-22" version="1">MFYHQNPITSFLLEFYCSLGMKGSIDEEYQKALQEAQDEGELQEIDLNESEITVTDKDGNKVQVKGDVEKGKVTKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEK1</accession>
    <name>A0A914YEK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEK1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17725.t1">
        <property type="protein sequence ID" value="PSU_v2.g17725.t1"/>
        <property type="gene ID" value="PSU_v2.g17725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000005">
        <property type="entry name" value="Regena, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="207"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17725.t1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43001" checksum="0292D2C5B3910B8B" modified="2023-02-22" version="1">MVINENEFPSLVRQTSTTSAGMGNGHISRTPFNPNGNAGIIPPGTPTAAAITAGLANIPSSYGSKDASGSMAGLQGLQRNFYSMMQVPNYNNEFIRNEQDFPALTPTSNQNPQAIGSTFSTDKDDGKKAAHLQRGIQAHQNGRVTNIPPGMVGDQYGMAGVLTFLKALDKNNGLVQLALGHDLTNLGLNLGSPDFDDILFFSRNLYQSFGGPFCDSSVRTQDIECNVPDEYRTSNHIKDKLPPIKLSKLGDDTLFYLFYNCPGEAYQMVAAHELYARDWRYHKTMAVWLTRSAYGNVKEQTSTYEKGSYNIFDPTQWRKIPKEMTLEYKDLEQRPAAIATDFNKPSGNGSGGNGGGPPTTSGIPQQKILTNFSSLNIGASTPTGPQTPGGTVGKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YET8</accession>
    <name>A0A914YET8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YET8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17815.t1">
        <property type="protein sequence ID" value="PSU_v2.g17815.t1"/>
        <property type="gene ID" value="PSU_v2.g17815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17815.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27012" checksum="A6F88B60E77982AE" modified="2023-02-22" version="1">MITLERNEGFEHYKKFGSFAALSAAEENGRSEVIRKSQSMCQPVSPFSCGLNIPEPLIEEPEPEPTIQRTVGRRTLPRNMSDRKLLTAIFEDQKTVHSNFYSRHFSGNPDERPSIFSAFDDEEKIDEEQENDTKYFTVPNPSNSVSPRHKPIPNFSRRDSVPVKTGSSNTTKNALKGLAKKNDRPTFFMGDDHDESKHDAGMITFKTGRFQVAKQSPSHSHSAHDEASALLKIEEEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFC7</accession>
    <name>A0A914YFC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19000.t1">
        <property type="protein sequence ID" value="PSU_v2.g19000.t1"/>
        <property type="gene ID" value="PSU_v2.g19000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098830">
        <property type="term" value="C:presynaptic endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016182">
        <property type="term" value="P:synaptic vesicle budding from endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048499">
        <property type="term" value="P:synaptic vesicle membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19000.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7680" checksum="C0F45BAE43CD5A83" modified="2023-02-22" version="1">MTLRNIRNNLDRLFDKNLTDLIRGIRNNKENESRYIAACIEEIKLELQLNSTEVKANAVEKLAYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFS6</accession>
    <name>A0A914YFS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18302.t1">
        <property type="protein sequence ID" value="PSU_v2.g18302.t1"/>
        <property type="gene ID" value="PSU_v2.g18302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18302.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25607" checksum="F31281C502778321" modified="2023-02-22" version="1">MSKPPSLREKLKNAPFCIRPSSPTFNYLNGIDPILLQMDREMEKVEAIDAARTAAMIKRRYAVTSYPCNPGQGHGYNKFITSNHEEVEWNEEIFQRLKEIGVLVFKNDKNEIYFYIGEMRFCTLLELVDERWNNTGCNNAGESAIFEPMKEIVMREITAELRKNFQRWKIFLEPIRSHRCVHDTFIRVLILSQTFQILIIKTLVGMLQKICEHKKMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG02</accession>
    <name>A0A914YG02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16273.t1">
        <property type="protein sequence ID" value="PSU_v2.g16273.t1"/>
        <property type="gene ID" value="PSU_v2.g16273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16273.t1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38844" checksum="8356F008C1A1EF4E" modified="2023-02-22" version="1">MVSGLPAIIPQAGSPQFVYATSINGQPVPVSIHQPEREQRRDSKISLPPIFNFSQPFTTPASPTTSETTSSLSWNSEHEKHEMITSIGMTNNENSWKMQEEMPNLHLSQCFETKKQKNHCLEPLKLKEVPKQKINSFDEKIEEKQQLPPRTPSPIDKRPIRPSPGGRYQIPDLPCEDLYHAVPIKDKEAPKKEKNNNNNNNEESPKKRSPSDLGLFSSVEIRSPLRRRSDMLPPRPPTRNTSMTKLASQLSPKATTPPADLRRTTKQPPLPSSDSSNSINADPTAQESPRTFFTRNKQYRSFNVKTTNVGVNPAVEHLKMLKQKLLDHQQVIKNRGVFQPREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG68</accession>
    <name>A0A914YG68_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="5">6.2.1.4</ecNumber>
            <ecNumber evidence="5">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="5">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.4" evidence="5"/>
    <dbReference type="EC" id="6.2.1.5" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YG68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17766.t1">
        <property type="protein sequence ID" value="PSU_v2.g17766.t1"/>
        <property type="gene ID" value="PSU_v2.g17766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5 6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17766.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="28210" checksum="91DD3C8042DDA894" modified="2023-02-22" version="1">MSVLINKNTKVIVQGFTGQQGTFHATQMIEYGTQVVGGVTPGKGGTTHIDLPVFNTVADAVQSTGANASVIYVPPPFAADAILEAAAAGIKVIVCITEGIPVLDMLRVKNVLTRSYPDTVLIGPNCPGVITPGECKIGIMPGHIHKPGKIGIVSRSGTLTYEAVKQTTEVGLGQSTCIGIGGDPINGLNFVDCLKLFNEDPQTEGIIMVGEIGEAGRRFHRRASAPAGKRMGHAGAIASGGKGTAEGKFAAMEAAGVVTVRSPGDLGAAIAKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGC1</accession>
    <name>A0A914YGC1_9BILA</name>
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        <recommendedName>
            <fullName evidence="7">Osteoclast-stimulating factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGC1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g185.t1">
        <property type="protein sequence ID" value="PSU_v2.g185.t1"/>
        <property type="gene ID" value="PSU_v2.g185"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="PANTHER" id="PTHR24155">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155:SF10">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040640"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g185.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23575" checksum="3C031E997694B9EA" modified="2023-02-22" version="1">MAIPPPIRKPGRITVYSALIDYEPTTPDELKFSDGDLLYIQEDVNNSEILKAKCGKREGIISKSLLNDETLMIIEHPLHQAAKQGNLELVNEYLSNNISVNSLDRSGSTALFWATYGGHLDVVKVLLATPHISTVSQNKMGDTVLHAAARKGQLSCLQALIESGTVNSIIHSRNNDGKTAYAVSSTPEVEALLQVTMREVAEPAAIEEYISSDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGD7</accession>
    <name>A0A914YGD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17844.t1">
        <property type="protein sequence ID" value="PSU_v2.g17844.t1"/>
        <property type="gene ID" value="PSU_v2.g17844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17844.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16023" checksum="FF9E487AE7C7E043" modified="2023-02-22" version="1">MPCFEQCSGEPQKVSEGPPPPPKKNIATTKYNKKLIEHLTKNLFSDFDHGDKKYYESKPSDKNVSAEFESNAKIIFYVGMSLLILAVTTIFAKHFYSKWKKRPKAVKKEVKEAEQEEPVENNDQNENFNEPEIVQMPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGQ5</accession>
    <name>A0A914YGQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGQ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18637.t1">
        <property type="protein sequence ID" value="PSU_v2.g18637.t1"/>
        <property type="gene ID" value="PSU_v2.g18637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18637.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9360" checksum="4F68ACABE378E53B" modified="2023-02-22" version="1">METFMKRLLKKLLQTSPKSPAKAAPKSPAKTPSSSTNWLLVNRQRSNCESSSDLTCYAPEDGPVSKYHLEAADSDDNQHPQSTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHD8</accession>
    <name>A0A914YHD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18207.t1">
        <property type="protein sequence ID" value="PSU_v2.g18207.t1"/>
        <property type="gene ID" value="PSU_v2.g18207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18207.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15209" checksum="AB508FF8BA4E1814" modified="2023-02-22" version="1">MKVFALYKGSSAPAVCVTPIFALYFGGCAVGRWLQRTEPDQELTFVQTWGAGALAGLFTTIIATPGERVKCLLQVQLADTSITAVKYSGPIDVITKLYKEGGIRSIYRGGAATILRGMLYFCLTTYSPPLKVRSSLPFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHN3</accession>
    <name>A0A914YHN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactosyltransferase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHN3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18303.t1">
        <property type="protein sequence ID" value="PSU_v2.g18303.t1"/>
        <property type="gene ID" value="PSU_v2.g18303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046525">
        <property type="term" value="F:xylosylprotein 4-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF30">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="2">
        <location>
            <begin position="47"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18303.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17908" checksum="E5AE39869D3F37E0" modified="2023-02-22" version="1">MRIKFRRKSYCCILISVFMVFLLYEWLTLQPTNSQYEDPLLVKGNILCVLVPYRDRFEELQQFIPHMEKFLNSQNVAHRFIILNQTDSLRFNRASLINVGWLEADRLRCNYLVMHDVDLLPQNLELDYTYPGIGIVRHIAAGKYHPKKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHP3</accession>
    <name>A0A914YHP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18312.t1">
        <property type="protein sequence ID" value="PSU_v2.g18312.t1"/>
        <property type="gene ID" value="PSU_v2.g18312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF566">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18312.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34535" checksum="BF8DFE868EC8CE94" modified="2023-02-22" version="1">MAQTEPEEEIQIVTKDQINFGETKRLLGRGAFGKVYKCTFTDPEGRAIHAAVKVIDPIYRDADIETERRRIFDEFRNMMIPRHPYVIHLLGINMADDLMLIMPLRKECLKKYLACSKNPVPVNRLSRFCSQIADGMMHLHSHNVFHCDLKAGNVLIKDEFHIEICDFGLACPSIDDKGRYRGGTFSHMAIELLSPLKTKVFTQECDIWSYGITVWEIYNLGKSSPYEIEGRTPITLYEFLENGGRLKKPDLLKADVWPNILQCFAKNPKVRPKFGKLFKTFTQLANDKTPVDDETSRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI55</accession>
    <name>A0A914YI55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI55"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17002.t1">
        <property type="protein sequence ID" value="PSU_v2.g17002.t1"/>
        <property type="gene ID" value="PSU_v2.g17002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17002.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12886" checksum="19F26328523419A3" modified="2023-02-22" version="1">MRPRLRPKPKIWYEKFVGCTFYQAGGFGNQIWRLASLYGIGKTLGRQPYIENRVLLNDFINATWKRMNLTEIGFVFPLMYSTLNIMNPPNNLTKIANFAKDCCKYDEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ89</accession>
    <name>A0A914YJ89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJ89"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18905.t1">
        <property type="protein sequence ID" value="PSU_v2.g18905.t1"/>
        <property type="gene ID" value="PSU_v2.g18905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18905.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26012" checksum="F0DE73E1B4359DA8" modified="2023-02-22" version="1">MRFIKLEWQEATCPECNDIGYCNLPETNGSTELPCLCQKSNYCLLRPERLKRIWEIRGSEIPDEGSPFRADFLEQLQKLGYENMTDEVAITTKTKEKMILTMAGLPVHRRIALSYGKAEFIRMCSFNGQQCNIINDFKLHVDPAFGNCYTFNANRENPLIPSRAGPSYGLRLMVYINASDYLPTTESQGVRIAIHGQASNGFRIIFWAFNGMYDYGIAKIRFNISKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJQ8</accession>
    <name>A0A914YJQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20575.t1">
        <property type="protein sequence ID" value="PSU_v2.g20575.t1"/>
        <property type="gene ID" value="PSU_v2.g20575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20575.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11379" checksum="42C66C71B40E8EE6" modified="2023-02-22" version="1">MAESIPTSDINNPQSKVSAHQSQTAAAASGNSGDREDSVLLAVSSQAYQFQPEDTSSTSTAASASGAWTGNSTTATSEAQKKQFNHEWLKAAPASDATHKNQKYEYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJU5</accession>
    <name>A0A914YJU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19800.t1">
        <property type="protein sequence ID" value="PSU_v2.g19800.t1"/>
        <property type="gene ID" value="PSU_v2.g19800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851:SF5">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19800.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11321" checksum="AE865DA9F955EB47" modified="2023-02-22" version="1">MSSSTSYTPSKVPFEHYAPQYRCCCNSVHVRQGTQIIGVIQTVCAVFALIVFLFSSHVDAVWSILETASVFGEIVVITLLFVAIKKENPRFLLPYLVYEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKD8</accession>
    <name>A0A914YKD8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
            <ecNumber evidence="2">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4'-phosphopantetheinyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:12069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + acetyl-CoA = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46565"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YKD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20806.t1">
        <property type="protein sequence ID" value="PSU_v2.g20806.t1"/>
        <property type="gene ID" value="PSU_v2.g20806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000003">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF23">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="10">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="9">
        <location>
            <begin position="124"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20806.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34755" checksum="EF24D76364F805DC" modified="2023-02-22" version="1">MASTRENINPKCKCNRFAFSLQKAFEDEHLEAYFRKAIQCVNQEDYDKIMAFRYKDDSLACLAGRLFLRQISKRFTDAQWHEIEFARTEKGKPYLVKPEGHSFGLNVSHQGDYTVFASSCSEKVGVDVMRLDINRNNKSADEYINSMARSASAEELKQMRGQATEAMKMTMFYRYWCLKEAVLKATGEGIVNDLSRYDFRIDPSDRFKPGCFLTSTTVLADGKLQNQWTFEESFVDSTHAIAVCREKKLPKTCMFAEDPESKLFFSKVGFDFLLNGATVLNPLPNDAATEYENFQEKLRKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMF1</accession>
    <name>A0A914YMF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMF1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20561.t1">
        <property type="protein sequence ID" value="PSU_v2.g20561.t1"/>
        <property type="gene ID" value="PSU_v2.g20561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20561.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="9912" checksum="56FB5014BA442B6D" modified="2023-02-22" version="1">MPLSCPSGTFYSAFTEMCDYKANVVECGGIAPTKQPIAQNPVMIPQSPYGRRPEQPALQATVTPQISYGQNPQPAQQAPAKSTNPCASLTNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMQ0</accession>
    <name>A0A914YMQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Toprim domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMQ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20211.t1">
        <property type="protein sequence ID" value="PSU_v2.g20211.t1"/>
        <property type="gene ID" value="PSU_v2.g20211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785:SF1">
        <property type="entry name" value="DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="DNA TOPOISOMERASE, TYPE IA, CORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20211.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10598" checksum="433A0364C96DBBA8" modified="2023-02-22" version="1">MPKHLLIVESPAKAKTINKYLGKDYTVLASYGHVRDLIPKEGAVDPDNGFAMHYDVIDKNEKHVDAIAKAAKGADDILLATDPDRRVKRSAGTSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNB3</accession>
    <name>A0A914YNB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2089.t1">
        <property type="protein sequence ID" value="PSU_v2.g2089.t1"/>
        <property type="gene ID" value="PSU_v2.g2089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2089.t1"/>
        </source>
    </evidence>
    <sequence length="901" mass="102268" checksum="0C1E3E72818DDF32" modified="2023-02-22" version="1">MQACRDLAEDAMDIFSCFCCTQCKPRYKRLVDSIYPRNLSDGPVWSNMQKLTFYAMSHPEKLNRIGIYIVNRLSRDLYRQRVSMVEVSVEAMDQILKACHSSASLQQFFESYLKMVQKMLESNDPHNEKLATDLFVAFANITEDSTSYHRQYDFFISKFSSMCHAFRGEDTMTRKFNGLRGLRGVIKKSSNELQVSIWEKHHMDKIVPSILHNLPDRSDEENAVYSSGDGEINDDDPYALAIQCLRELMEKSSFGSLRAVLEPVMTYCDANNKWDPPPTFAINTFFIIIYSIQTQTAYFVIQDLINHLENMTNAAASIRIGIATVLQRIVSKSGTSIGPLVLGIFHSLLKRLRVSVEFQQSRQCPSVDEEKAFQRTLMDAMGDFANALPDYQKIEIMLLTASNIPIITQEERKVKTSDEILQKVLVKTLLKVATKYKTFYFTTLFSEAFLKTLLQICLAPNSDVRLNGQLVLHTLFDRHDNLRQLAHLPYIREVEDLQLSIDKCPRQDLIFMHRQIPYITSVLFRVVCLADDGNDTRLHDQLDAVLCSMCLLCVEVGHDETLTELFRLAFGLQAFAVDTKDCRFNLKKRAEIHNLVAKFLNLSAQLLAIPALCQHVTQVINLRTQRGHPRLNIVASAAPLKDPLQTLSNGKAPIAHMESEDDITTRPLGIENDPSLLFDLEDVSEALKSSNKDITRLLIPFKPSTIPGVSTVAVDEIIGIKDLNSKQGSDMPPFIFGPSSSVIFTATDEADIIDRRDVVQVLDDEILSLSSSSIEWTPPASELNSRRNTVFGNHHHLDHRMAEYKTPITLDNVRAELSLPIDMAEEDRKDQAKSREIVQMFRERPLDELSAMLVKDLEETDLSKTIDTLCKKNNEWAKIQEFGSVGKAKTIFDIKFPSIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNY8</accession>
    <name>A0A914YNY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arrestin C-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21337.t1">
        <property type="protein sequence ID" value="PSU_v2.g21337.t1"/>
        <property type="gene ID" value="PSU_v2.g21337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="153"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21337.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38990" checksum="D6A231BC2A562E98" modified="2023-02-22" version="1">MSNLQLILDEPSATFYPLSPISGQLIFESVDSIKVKDISVKLFGKAEVKFSDEINGKHEIFENEQIIIEKDFVLWSHDEKLAAGKHDFSFKFILPEECSPSFMGENGNIWYKLIAKVNASGNDELEVEEIITVSPMTYISTNSPIICTTTFSNVSITANVPYRIFNLDDEIPLSIEITNFSNFAVESIEAGLCWSSTFFGKPLSTDSPAKCETIKGELDYANIPFSVPTGATTTFNHTLKSTATLPTISSCPILSHNYLICVRIHFFGASEHVQEFFIPVILSKIAFHKIVESGETMLPSESAEIGTFPKVTVPQSHVEKNKDTSEISTDHGTNELNCSNTDGETPAPDSLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP94</accession>
    <name>A0A914YP94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipid-binding serum glycoprotein C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YP94"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20812.t1">
        <property type="protein sequence ID" value="PSU_v2.g20812.t1"/>
        <property type="gene ID" value="PSU_v2.g20812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF144">
        <property type="entry name" value="BPI1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036696883" evidence="3">
        <location>
            <begin position="21"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="4">
        <location>
            <begin position="99"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="5">
        <location>
            <begin position="499"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20812.t1"/>
        </source>
    </evidence>
    <sequence length="780" mass="86301" checksum="2FE5BEBAFAD9DA71" modified="2023-02-22" version="1">MGFTVFCLSFFILYFPLVISLPLSSVTGSRRVLLPQRQPLHAARTFTGRTLDYEDDLVAIGKGGVISANKSLAVLNRSQKDYDPILLKGIRGNPGIKIRVNKKSFDYFTNIFAPIIEQEIRRARIPPTVECITKLNGCIQIYNAYISHYRCPQKITIYPSSPYHLVVSIQNMGIGIAGNVIGEFNVIIPVKVSGILHVTAQQVSATVSLGIVQSGSGPPYVQVVDCQVTVGYVDAYMEDGGIVGAIANREFRHQMNQQIRARIPSKICERIPEAINNKLNKKLQDIPQTVALLELLQLINGAFALGNGPNVCEKRKHCTVAAAVEEELLTLSNETTKILRDAPIIDDETDADLLGPRLVPLKRPRILSGSTVKNYVVLAKSRQRFVSKNEDVPIILAENSDAPFNLPPSPPHPNIAFITAPEPKLNCTELPPVSNTFCRVRKFIDKLDISKLQTSLLTTHLLQTFATSDDYIIALNGEVSEFGRGGTPFGAFFIDFPNKKVTKMIEILVSDFTMNSLFYLMHKKSFLSFWFDTDSPKIGSLLRTSCAEDDEERDSVVEENSEEIIATVKEKARSSLSSIPRSRRQAETVDAFEDLGLCFGDLFPLIRKKHPNQNVSIHIYTKRAPSLILHKHPKTSADINLALLGDIFVSGEEKVGTLLIETTINIDILIKNQRISGYSDVQDFKLTNPGETLGVPQAALDKLGDIGKQFFITALNEALEKGVKIKLPSTKDISLPFNIIDLKFDIVEHAIYFAFDFTVSPSIVSKLVGNVSNNDSCSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPD1</accession>
    <name>A0A914YPD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPD1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19213.t1">
        <property type="protein sequence ID" value="PSU_v2.g19213.t1"/>
        <property type="gene ID" value="PSU_v2.g19213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19213.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="10053" checksum="E4FC20C8F88B892D" modified="2023-02-22" version="1">MLGVVCHQKCLKLWYGKNLQSDPPPHWRDHPNAKIVRQGYIEGDPIEEYRGDDKYKFKKQREFDPFPLSRPVDYVPRRYDDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPR3</accession>
    <name>A0A914YPR3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA 3'-5' helicase Q1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YPR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g281.t1">
        <property type="protein sequence ID" value="PSU_v2.g281.t1"/>
        <property type="gene ID" value="PSU_v2.g281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030894">
        <property type="term" value="C:replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g281.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16094" checksum="2E917F4741CFAC39" modified="2023-02-22" version="1">MSRRKVEETAEFLCGQGFNALPYHAGLPPDVRANNQRRFLREDGIVMCATIAFGMGIDKPDVRFVAHTDLPKSMEGYYQETGRAGRDGEAAEAWLCYGLGDVVLLKQMIEQSEAGEERKQLERAKLDHLLGYCESMHPAATATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR02</accession>
    <name>A0A914YR02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3203.t1">
        <property type="protein sequence ID" value="PSU_v2.g3203.t1"/>
        <property type="gene ID" value="PSU_v2.g3203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3203.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29423" checksum="4941A3FD3E191DAA" modified="2023-02-22" version="1">MFRTATYKPAICECDVFREEGDHQNRNAFTLFIYGIALIFIISLFTTIICFREYAEIRQFLYEPCNKTDMLSVQEVKDMIKHSKFLKGMTDNMALMKDMMKDVNKAWEGIIGKAAVIEQEKKMHEKFHKPLNDNYEKGQEIIKQQILERNKCAQGNFQNYVAKAFLRTSSALALIAILLSFFWFIFLFIISTQFIRAKFTKDEFLKVQNRSHKLFVRSLIAMIIFALIMYCQDFYISIYVNTFENALNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRW7</accession>
    <name>A0A914YRW7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRW7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2398.t1">
        <property type="protein sequence ID" value="PSU_v2.g2398.t1"/>
        <property type="gene ID" value="PSU_v2.g2398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="122"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="315"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2398.t1"/>
        </source>
    </evidence>
    <sequence length="625" mass="70767" checksum="171640F685DA19D9" modified="2023-02-22" version="1">MQRHFLLNPAIKAFASKRQISLTPVSLLNAHEYDLTDPEVQKLYKLYRPERITPHKRGIEMLKSASLNKGMAFSLFERHYFGIHGLLPPAFMTADQQAYRIMTKLRQQPDDLARYIQLDGLQDRNEKLFYKVLCENIKELMPIVYTPTVGQACQHFGFIYRNPKGVYVTINDNSISKIYQILCNWPSDDVRAIVVTDGERILGLGDLGAYGIGIPVGKLALYSALAGIQPRWCLPVLLDVGTDNPKLLNDPFYIGLRRKRVRGEEYDRLLDNFMHACTKRFGHDTLIQFEDFGNKNAYRLLDRFQESYCMFNDDIQGTASVVVAGLLACARVTGKPLSKKRFVFLGAGGAATGVAEMCVRQMQSEGLSFEQACDRIYLMDIDGLITKNRLRNLDRRHFPFAKDMADTKDLLSLVKEVKPEALIGASTVKGAFTHDIIKLMAEINPRPIIFALSNPTSKAECTAEDAYKLTNGNVLFASGSPFPNVEVNGKLYKPGQGNNAYIFPGVALAVILFKVRYIDNKLFLIAARRVANSVTQKSFNVGRIYPRIDEIRELSIQIAIELANTCYADGTAKLYPEPKDKEMFIRSQIYNPEYDELINHTWEWPEQDMKHGFPVPVVRRTSTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT12</accession>
    <name>A0A914YT12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DM10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YT12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2799.t1">
        <property type="protein sequence ID" value="PSU_v2.g2799.t1"/>
        <property type="gene ID" value="PSU_v2.g2799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="6">
        <location>
            <begin position="75"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2799.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="36214" checksum="4A035A76F272F741" modified="2023-02-22" version="1">MNRFKSEPHLSKNCDCFDDDLHFFSQSFVKPRGRQQIFDKKENVTFMKDPLSKPKKKSWEPLRNIPFAEYFDPLHKAALTFTCYLNETDGEDGELLKIRPMKLIYHLDDETMSLTEPFSDNSGHLQGRQFHSQKVERHKRQIGNDYLTWKDIKVGEDLILYGRAYRIVSCDGFTKSFLEDRGIKVHETETIPIDSWNLSRHFQTDKAREAEIKKYFREKEKISEMISWENIPETLTFFCAWLDKKSDFYGERIKRTFKFMMSSRDDSVTMIEITPGFGNQLFLKTDQLPYITSGKSQMFLLLNKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUU3</accession>
    <name>A0A914YUU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUU3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3914.t1">
        <property type="protein sequence ID" value="PSU_v2.g3914.t1"/>
        <property type="gene ID" value="PSU_v2.g3914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3914.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14769" checksum="921729DF4E899D73" modified="2023-02-22" version="1">MNLCDLPEDILGEISKHLPTVDDVLALQAAHPKLSNKIDRTFWRNPKCLCLSADQEIVPHLIIEETKQMKFRKHSWIRLQSVLSKTKNLKEIVLGHCGKYFSEETLCQALIFLQRNNGNNFFLNIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV20</accession>
    <name>A0A914YV20_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV20"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21344.t1">
        <property type="protein sequence ID" value="PSU_v2.g21344.t1"/>
        <property type="gene ID" value="PSU_v2.g21344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002457">
        <property type="entry name" value="26S proteasome regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasomal ATPase second OB" evidence="6">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="5">
        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21344.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28219" checksum="5C3129A3D969BA1E" modified="2023-02-22" version="1">MAPPSVSSPIQQRPVSTAGPTTGNSNENSLKVYYRTKIEDAQQRCAEKIQNVRRLQAQRNELNSKVRMLKEELMQLHEQGSYVGEVAKVMDKKKVLVKVHPEGKYVVDIDKGIDVAQLNVGCRVALRADSYALHKVLPNKVDPLVSLMMVEKVPDSTYEMIGGLDTQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGARMVRELFVMARFVGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV39</accession>
    <name>A0A914YV39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YV39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3531.t1">
        <property type="protein sequence ID" value="PSU_v2.g3531.t1"/>
        <property type="gene ID" value="PSU_v2.g3531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000009">
        <property type="entry name" value="Aspartic proteinase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000044">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037287492" evidence="11">
        <location>
            <begin position="21"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="90"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="329"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3531.t1"/>
        </source>
    </evidence>
    <sequence length="450" mass="49894" checksum="26956CB19957BA87" modified="2023-02-22" version="1">MAISRLSLLLLIVCIYGVDAKLRRIPLKKVETLRQQLTSSGSWEVYLKHRTENLRTRFMNLIDEDAFSAEDTPNNGEIDEVLKNYMDAQYYGVISIGSPPQNFTVIFDTGSSNLWIPSKKCPFYDIACLLHHKYDSGSSSTYVADGRKMQIQYGTGSMKGFISKDKVCVAGICVDNQEFAEATSEPGITFVAAKFDGILGMAFPEIAVLGVKPVFNQMIAQQRVPSPVFAFWLNRNPEEELGGEITFGGTDPRRFVAPIKYTPVTRKGYWQFKMDAVIGKSGKVACANGCQAIADTGTSLIAGPKKQVEAIQQFIGAEPLIKGEYMVPCEKVPTLPEISLVIAGQSYTLRGEDYILNITTMGKSICLSGFMGIDLPERVGELWILGDVFIGRYYTVFDFGQERVGFAQARDSRRFRVAPPVRKCPTISDCAFDDLIDEQLAGSNDDGYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVB7</accession>
    <name>A0A914YVB7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YVB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3922.t1">
        <property type="protein sequence ID" value="PSU_v2.g3922.t1"/>
        <property type="gene ID" value="PSU_v2.g3922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF418">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038159650" description="Carboxypeptidase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3922.t1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43492" checksum="21FA6E709B3A0C13" modified="2023-02-22" version="1">MRFTIIFAAFLAAIISFVYGANEIKSLPGVQFDIKFKHYSGYLQVSKTHFLHYWFVESQNNPTRDPLIFWFNGGPGCSSLDGLLNEMGPYEVNPDGKTMRSNPDAWNTFASVVYIESPAGVGYSYSSDGNTTTNDDLTSQENYEGIKKFFELHPTFRNQSTFIMGESYGGVYVPTLTARIVDGQKNFPINLRGMALGNGYVNEKLNVDTSVRFAYGHGLIDEKVWNTLEKECCRGCIDDCDLTNMTGHCAHMVEDIFKFLWFGGLNPYDLYRDCDPNPDTNSRRMSSYREGIIPRIFLKILLYYGDTDMACNFMMGQQFAATLGYPRQLNKTPWKFNKQIAGFKTLYKGVTYITIRGAGHMAPQWRAPETAYAIKQFVINHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVB8</accession>
    <name>A0A914YVB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4538.t1">
        <property type="protein sequence ID" value="PSU_v2.g4538.t1"/>
        <property type="gene ID" value="PSU_v2.g4538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4538.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9603" checksum="911315EFCBC75C14" modified="2023-02-22" version="1">MHGAELVNIVKNEQENKSLINDLTDLINEPLSAGITELTWLVGGMDTVLENPQLSYNLWMSTKIEDEHDKNLALQRKVDKHFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVT7</accession>
    <name>A0A914YVT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVT7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2194.t1">
        <property type="protein sequence ID" value="PSU_v2.g2194.t1"/>
        <property type="gene ID" value="PSU_v2.g2194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037915686" evidence="2">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2194.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32048" checksum="BE1FFCA5C8DB378D" modified="2023-02-22" version="1">MFVNFMGLISVFIFKNQAHVCIYQKRHDFKLMIFGKAANLTYDIPVFEDGSSFTIKQIAISGTRVTLLLISHKAAYRMLLHINGLEIINSVPLQYIGHANELVWQPLVDSDVYLKINGSNFVDTVRLFYENVSSSENISNSYQPCNKFKEFKILVVRNTTLTDKLPAVLPYNYLIIIICVLSVSLLLTCGFIAVFVFLISKKRGNDVGILRSVDPLTCSHVFPPPYETHENNYRRVNTPANIRVFGNSTATVMSQQLASFEECEESTYSNPESDKCSDNCSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWA5</accession>
    <name>A0A914YWA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWA5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3940.t1">
        <property type="protein sequence ID" value="PSU_v2.g3940.t1"/>
        <property type="gene ID" value="PSU_v2.g3940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037986238" evidence="2">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3940.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18574" checksum="63863557A203EE41" modified="2023-02-22" version="1">MQNGFILITFLIILINIKVAFSSFNQHISDIDLKQNDPFCVKSNQGNASNIANFIADYIPKTDKLEFSETWMFYIFDGFISVSVGATIGILLLQLLYIFFEDEIRIHGIVKGIYATIQHEVKTANEFAFKEAKRQLQLFNNNNNGPTRIKPSRATAYVTRANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWT0</accession>
    <name>A0A914YWT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWT0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2539.t1">
        <property type="protein sequence ID" value="PSU_v2.g2539.t1"/>
        <property type="gene ID" value="PSU_v2.g2539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="36"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2539.t1"/>
        </source>
    </evidence>
    <sequence length="464" mass="51379" checksum="3009169CE9E8B2BA" modified="2023-02-22" version="1">MPLKKKIFCHFGVILPKDLKPTVKRNAFDSDWSNDIPESFDFRVHGKVTPIKNQGPCGSCWAFTTAAAIESQYLLRFNQSLDLSEQSLVSCNSGAWGCNGGNVVQTLTYVQKNGIASETCMPYTVADGTCSTKCDTQKYYIGGYNHFGYDESKFASFLYNYGPAVVTMYVPPEFMLYDSGILDISKDECVEKNEGLHAMTIVGYTPEYWIIKNSWDTDWGEDGYVRVKRGINFCYLTLEVAAPYLNVTTVLPSTPATLKPTTPTPATPKPPTTPVVTPPPQPPTTPPTTKIPTRPPIPATTSAPTRPTSTPTRAIPTRPPTTPPPWTFPTTPTTPRQPIPVTHSNNNQGQQQQQFQGCSSGDGIRTMNDVTRGHVLNSINGKRSEIAHGQLQLSNGKRLPPGHNIRKLNYNCTIEYYAQHYASTCQQPNVPGTHMVLLAFPYDISISKYLLTFIKIGKKKCFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWX1</accession>
    <name>A0A914YWX1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stalled ribosome sensor GCN1-like HEAT repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2578.t1">
        <property type="protein sequence ID" value="PSU_v2.g2578.t1"/>
        <property type="gene ID" value="PSU_v2.g2578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Stalled ribosome sensor GCN1-like HEAT repeats region" evidence="2">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2578.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27728" checksum="24B12ABECD0B7CD3" modified="2023-02-22" version="1">MLSAVSQLVDETAENNNIIGIALLRKWVESSELLFDEGIVDEILPAAIGFYTNKSPEIVEEAIATVDAIIRQTEQGHAIEFLPLVKKSLEDIAATNAGENIVVPGFNKPEGFAAFLPVIKDALFNGTNGQKEQAIATCELFTRLASSSGILKHAMLICGPLIRCLGDRFLTEARKSALQTFKTLFEKVPTGVKIFVPQIQTELFKLLQVENLGSLKNLFATTLCHALCNHVKSETVFNDLIQFLLVNEDAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY74</accession>
    <name>A0A914YY74_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GST N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel CLIC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YY74"/>
    <dbReference type="WBParaSite" id="PSU_v2.g490.t1">
        <property type="protein sequence ID" value="PSU_v2.g490.t1"/>
        <property type="gene ID" value="PSU_v2.g490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053823">
        <property type="entry name" value="CLIC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920:SF5">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL CLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22441">
        <property type="entry name" value="CLIC-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CLIC N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g490.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28493" checksum="A19EFF1A90CDABB6" modified="2023-02-22" version="1">MSESLLDLWVKAGADGNCLGGDPQSQQLFMILLLKAQNPDCRFNVRTLNEAKLPQDFKNYGMRHAPALTHGEDIAISHPDEIVEYIDHIFPSPSLKYNNPEADGATADLFRAFCYFIKEVNKDPKALLNELYRLDQYLAHSEYRFLTSDKMQHIDCNILPKLHGIRIASRALKNFEIPVDLNYVWRYLHEGYQQEAFRKSCSSDQEIILYWAERKDTPDLPAAKRSQLSRQKPIFTMEVPRESLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYT7</accession>
    <name>A0A914YYT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYT7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5116.t1">
        <property type="protein sequence ID" value="PSU_v2.g5116.t1"/>
        <property type="gene ID" value="PSU_v2.g5116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5116.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14153" checksum="C64388013552F884" modified="2023-02-22" version="1">MELNATIQTYSEANKQIEDISDESSSSSKELAQNHGLTKFNEENSFWKSASETWQGFSEHYQKIAAENAENLKLCSDKAKMQEETIEELNALLDQNIKQKNLLEFLKNHYKDCWERQSYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYZ3</accession>
    <name>A0A914YYZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g326.t1">
        <property type="protein sequence ID" value="PSU_v2.g326.t1"/>
        <property type="gene ID" value="PSU_v2.g326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF8">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="69"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="264"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g326.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40054" checksum="594763E388F66CDE" modified="2023-02-22" version="1">MIVNLPLCNYYRHRKTKSALIAFYKRQKYIQECHDEDEAILQRDHDDHQRENQEQRDSKARWDDILAKATLGINVIMIFAKLFAAYLSHSMSIISSVVDSLMDITSGAVIWGTLRSIDKTNPYEYPIGRTRLEPLAVLIVALIMVFANVMVIYEATMAIINDTLNPIVDIETLIILLTGTAIKSVLYILCRRQKTLSSKLLAQDQLNDVITNIVALAGAYCGHQFWKYWDPIGAYLVSGYIIINWLGTAREQIPLLIGRTATQDFINRISRIAISHHEKILALDMVYAYHLGQNFLVEIHVLMDGSLTLVETHDISESLQTKVERLPYVERAFVHCDYKLDGDEHLKKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0B6</accession>
    <name>A0A914Z0B6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z0B6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3720.t1">
        <property type="protein sequence ID" value="PSU_v2.g3720.t1"/>
        <property type="gene ID" value="PSU_v2.g3720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3720.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13691" checksum="3181ADAEABD90737" modified="2023-02-22" version="1">MFALQCQDALEAVHPWIVSAIRKESEEKIAEAWNNIAVPKFRDTFGKYFEAQLKKNGSGYLIGDKISWVDFIAASFCDVMVYRGNSSALDEFPLLKTFWKNIYANPKLAAAIEKEHSYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-06-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0C2</accession>
    <name>A0A914Z0C2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g3725.t1">
        <property type="protein sequence ID" value="PSU_v2.g3725.t1"/>
        <property type="gene ID" value="PSU_v2.g3725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3725.t1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41995" checksum="EB61B2FAC05957E1" modified="2023-02-22" version="1">MKDYAKTSNFPTAVSISIRCSKMDEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRMALKLMQICKYFQHQEFPYFVVKRLSGREDRWIYHPLQKDVFLAVPKYYQNIDLNILTKKLWIIEELSFWFVSERTNSIETFLPKVAVCDIHILDFRVQSIKFEEFKILTASGTVTELHLENAFIKNNGKNVPLEDILEILPNICKLQLSEDANSFVSYESAIEKVPQSFKKLTLQDIRTEFNFEDIFKFIQNNQKIYLMFFWNTEFTATDENIQKIQILTDNLIEAWSPQYQPPWIWFMTQTMESIAKLQKLKEIFEQSLKAPPNLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2E1</accession>
    <name>A0A914Z2E1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2E1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6527.t1">
        <property type="protein sequence ID" value="PSU_v2.g6527.t1"/>
        <property type="gene ID" value="PSU_v2.g6527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6527.t1"/>
        </source>
    </evidence>
    <sequence length="434" mass="50327" checksum="103B510EB982D1D4" modified="2023-02-22" version="1">MEQLYQDAMAIVRRFGKPDLFITMTCNPNWKEILENLLEGQTPADRPDLVARVFKQKKDYLINLISKEGYFGKCKAYVYTIEFQKRGLPHAHILVTLEGDYKMRTAEVIDRYISAQLPDPTLYPKLHELVVKHMIHGPCGPRCEKDGKCSKHFPHEFQEETSLDEDGYPSYARPDNGITVTKSSGFVVDNRYVVPHCPNLLLELNCHINVEVVSSIKAVKYLYKYIFKGHDSAAMKIVDGSVVYDECESFLDSRYMGSAEACWRILGYELHGQSHSISRLPLHLPGEQRVSFVDAENEDELKAAMEKMSMLMEYFELNSRDPKARELYYHEIPEKYTWKKVTEQGQTPKMQWCERKSHFNVIGRMYSVSPTNQELFHLRILLNHVKGATSFDDLKRVEGQQDPCQTFTQTCLELGLVKDDKEWEKVLNESKNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2J6</accession>
    <name>A0A914Z2J6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2J6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6295.t1">
        <property type="protein sequence ID" value="PSU_v2.g6295.t1"/>
        <property type="gene ID" value="PSU_v2.g6295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000002">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6295.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33547" checksum="545E8CB99DF1C9B5" modified="2023-02-22" version="1">MFILQQYNVYVYEFLQRHFTNAKNGGNPERVLNNVPDFDGGHYFICNKNDDKNLIMISLNIRYYKELQSHGCDAFLRSHYSGYIQDTPEEGYNVSLVFDLTKLPDDLDALALKAAHLKRNCFASVFYKYFDIQAKLEKGEPATHTRAVVHYRPDETLFIDAKSDRVTVIYSTIFKEDDAVAGKLFLQEFEQGRRSSQTAPQVLYRIREPPNELKDCKDALVGENVGYITFIFFPRHLTPANRDNTINLLHIFRDYLHYHIKCSKAFLHSRFRQKATEWLKVLNRAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2W2</accession>
    <name>A0A914Z2W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2W2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7043.t1">
        <property type="protein sequence ID" value="PSU_v2.g7043.t1"/>
        <property type="gene ID" value="PSU_v2.g7043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7043.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16876" checksum="EBB2609F64983B48" modified="2023-02-22" version="1">MAEVNTNEMPKLDENVQSELTKQHALNHVDTVEKNKLPTKEDVEVERQHVQLKQGIENFRPNTLRQVSTDEKIILPTPADIAKEKAPQLAANFDKNDLKSVETVFKSGLPTPDEYAREKVKALASNFDHSELKHVEPQVKTNVAVIEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4L5</accession>
    <name>A0A914Z4L5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ANK_REP_REGION domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4L5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6840.t1">
        <property type="protein sequence ID" value="PSU_v2.g6840.t1"/>
        <property type="gene ID" value="PSU_v2.g6840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TANC1/2-like AAA+ ATPase lid" evidence="5">
        <location>
            <begin position="300"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="TANC1/2-like winged helix" evidence="6">
        <location>
            <begin position="395"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="619"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="721"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="791"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="824"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6840.t1"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115768" checksum="F4DB36D844C39441" modified="2023-02-22" version="1">MRQQDRHSLRPSYQLNGLFNHPSLKSLSPSVAADVNVICNNSLPKQTFLKISPLFSLSDVLMEGEAENAFLGREWVFKELYQMIVVEHSTFTFIQGCNGSGKTAITRQLILQSLFFSQNSVNGDTVDSGIVIESQSSLNSTLSSKNYEWLRAVGVRIVAYHNCRLYHASTCVIPEFVLNIAAHMYNSPLLQSYADLIRENKELIELLQSESLCFTIEPVELFRKLIIEPLKRVVISDDECMIIIIDAIDEADFHRNESGESIAWLLKQVSSQIPVWLRFILTSATMAPLCGLNVRTLQIDDAELDQRVMRDTQILLEYRITVSPQLEQKLRSCSASESINEVIDELVARSRGNQLFLTLLLDLIEQNRINIMSSSIALLPTDLFQLYLLYFNLTFKSLAHFHTVSPIISTIIASLKPLDFNDIYSILNSSQPEPYITRDEVAARLAMLTPMIVKLSNDKYAPLHPTFREWVIKMSDQTDYAIDIRQGHILHSLYLVRKGNLSPELFFELGHHLLKANPYKYMRPGTAPDLPNGKDCHILWIQRAAGHPSALQNSLLFERNCYYPNSKVSRLLLLSGANTNCCWPDDSCLLSTFANTGNITMIQLLIQFSVDLNYVNPKTGQTPIFYAVQKAQLDAVRMLYEHGAKVNIYDSNDLSLLDYTAKTNSVKLMSFLLECEWSVRNQKDKGKNRAEALKRAFETAAANGQVQICEFLLDCTDAITNTSTAMCVACANGQSETVQFLLSRGATLSTNQYWQGKSALICAIESGSWDLVVNVLNSSNIDLNADNTSDDGWTPLIVAARYGHVGLVDLLINRGADIDIKDKNGLTAIMHTVICRHASTAALLIDRGCDITVKDNNGNGLIHLLAQYSNKCLIDRLLEKGLSLEDKNNEDLRAVEIAIRYGNQNAVDIFLRRGARLRTLTWRVAVISEPEFVLVLIRKLLDDAAILFRRKRPLEALHRFEYALEKCSELMGDKIDQENIMQASNVVKNKTEFIRLAPIQGQLREYKVQILLAMASLKEKIMNSLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z521</accession>
    <name>A0A914Z521_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z521"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6997.t1">
        <property type="protein sequence ID" value="PSU_v2.g6997.t1"/>
        <property type="gene ID" value="PSU_v2.g6997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF133">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6997.t1"/>
        </source>
    </evidence>
    <sequence length="408" mass="47145" checksum="AF30B42ABBE4318E" modified="2023-02-22" version="1">MNVNIYETSLVKAESPEINFKFQNPHSFSVKTSGGFAQFKGLYKGVYRTCRDGQVYIDLSGLNLYLQVDLTRSDENKFHPKISSCEFSVDEIFVEMKRPLFPQAIDAFKQLFLKYLSKQMCKFAENYADKIGDKFQEALNNSPISLKELGLHKFDSTLIREPILDKNSLFFALNGKFGQKEESERSRMFETDTNHMIYTYISEFVFNEFLNSFENKELKIEKSKKMDELLKNYKLMKSEDSMDIRIKFNEAPKIQFMDYGAKLVLNFNALLKSSSSDESLVSANFKLKTLIEKFEINAVLDGIFDDNNNNDDDYKLNAKVTIDDIEITDIISFLPEAFNLAEILPHVIKANKDIFGEIIESNLHSLFPIETNSYLRVTTIKGFFRSKTLIFGFDFASDGHLIRRLQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z529</accession>
    <name>A0A914Z529_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z529"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7456.t1">
        <property type="protein sequence ID" value="PSU_v2.g7456.t1"/>
        <property type="gene ID" value="PSU_v2.g7456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7456.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29845" checksum="5B656F45C71EA2AD" modified="2023-02-22" version="1">MLPKSTAEEMKLNKGTILKASCDYIRQLQQDRDVMLKQQHERQQLEEATKLYAKRVRELEDALQKNGLNIPEGTNPPPLPNKTSSENSSNNRPIKQEPFEEPLSPSQTPTGSYPSSGFMSQMQEMQITSPGYHQNSPSGGPLVGSLPSDTSFGHYHHRQNNYFNASSPISTPQNSSNHGSLSEYNTPNTWSPLQQNMLHGNGPFDFVMEDLTSQNRNSLQQGDPMLGGSNLVSSQMSPDIQWDNAGFSPESQHNTGNTPNPHSSLSIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z679</accession>
    <name>A0A914Z679_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z679"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7449.t1">
        <property type="protein sequence ID" value="PSU_v2.g7449.t1"/>
        <property type="gene ID" value="PSU_v2.g7449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7449.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17162" checksum="02A66855A25CE4BF" modified="2023-02-22" version="1">MAAFDQSSFARAVQKREAKKSAQIQSSRTHSKSSTTTTTSVFRRKDKSEKENILLSKKDKSATGSEMTMKKKLLGKLFKILTLKESSTKKCSKEDKKSCHTRRRSRSSQSSTPSNFEPMPTIYEENEESDLISLHSFAIHKQQTYQYIAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z710</accession>
    <name>A0A914Z710_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z710"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7692.t1">
        <property type="protein sequence ID" value="PSU_v2.g7692.t1"/>
        <property type="gene ID" value="PSU_v2.g7692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141739">
        <property type="entry name" value="MFPT repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7692.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20869" checksum="5DFDB4E6DEE45968" modified="2023-02-22" version="1">MEKEKMRKVYRFPSLILFLFIFVQIEALWIGEEYWTIVDRGGNLRNGRTFEDFIRFKGFEVDEFVAYWIINHDDKQFEAYGEGYLKNGRVCARFIDENDQPTEICGGFRILSKGFNDGSNPFEWYSISDIPIDRTVEYVRHQIAQVWHDQHQQSVFGGAHITRGLAYAVNLNGTSLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z742</accession>
    <name>A0A914Z742_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z742"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8512.t1">
        <property type="protein sequence ID" value="PSU_v2.g8512.t1"/>
        <property type="gene ID" value="PSU_v2.g8512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF12">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8512.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24744" checksum="86DB229F0C800EEC" modified="2023-02-22" version="1">MENNDKTIIHSGTVQYYKTTSFSSKWKEVHGVLYSNSTFEWWNKKKPTKQMGSINLKNLIPYFCIGSQTTSIIGKPILDKKWNSNALIAIAKNEKINKIYWFYFDSESILEAWINGITLTLPNPEINPSHALKNNNNIENGRGRCNTFSVNYCAFSNDDSYLSKTITDYGFGNLFHRKSTHFVYHAINERHRQQRNSIAADTINLKSRKVFQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8R1</accession>
    <name>A0A914Z8R1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Transcription factor E4F1</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Putative E3 ubiquitin-protein ligase E4F1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">RING-type E3 ubiquitin transferase E4F1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Transcription factor E4F</fullName>
        </alternativeName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 32">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z8R1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6636.t1">
        <property type="protein sequence ID" value="PSU_v2.g6636.t1"/>
        <property type="gene ID" value="PSU_v2.g6636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003017">
        <property type="entry name" value="Si:cabz01054396.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001557">
        <property type="entry name" value="Transcription factor E4F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000702">
        <property type="entry name" value="Transcription factor E4F1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF159">
        <property type="entry name" value="GROWTH FACTOR INDEPENDENT 1 TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0498">Mitosis</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0678">Repressor</keyword>
    <keyword evidence="20" id="KW-0804">Transcription</keyword>
    <keyword evidence="18" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <keyword evidence="14 27" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="29">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00083844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6636.t1"/>
        </source>
    </evidence>
    <sequence length="792" mass="88423" checksum="56DA394EDFC24EB1" modified="2023-02-22" version="1">MMVHVDQPISSPNSVYESSEHLTHQNHSSKFNNSNSEFSDSPRNTLSIDSESPIYSSRSSVINEIYGSANELSPISATDSDISHEEATSSGISTMSGRSGISSRIPPSEDGGYDEEVDVETVEMEEDDDDDDDEEQKIAEQLAEEEILNQQKLEVSKAIAEGRRPLTVTGISLERRHVCDICDKGFSYLSILESHKRCHTGEKPFACHFCDKHFAQKATLQVHERTHTGERPYKCKYCDKTFAQYGTKTVHERSAHLGIRNYKCPKCDKCLSSPSALYTHKKTHGDKVFHCPCCPKTFTLKNYLKLHVKQVHEQNERKHVCKFCSKSFAYAGSLQVHVRTHTGERPYVCKYCPKAFASQGNLQSHERTHTGERPYNCSQCGRAFIQKSQLTAHEATHNMPPTAEVIVEEEEEIQPLPPPPRKTNDYVCKFCGKRYAYASSLYVHTRLHTGERPFRCNFCDKKFTNQGNMQVHLRVHTGEKPYKCEACSKCYAQKVGLKIHQEQCQLYMQNRRDSVLTNATTDSGCSDLMSPLRMDDDYMDFETQHNNFEEKLQAMNSQPPLGLQIPPSFHSQSSMNEQHLSILRKASVASTIGASSSQRSSIADLFGQPGVCFVDPQPTSLQLPHPVPLTPSYLSNPSQSDLQKSAFTLLHHDDRRVMSSTDTTIKALLDILHAQQQQQQQQQQQQIALAQLQNALGPQLLHSILATANIHQPLTPHTPLTPTLNPLASIFAAAGLPSLSSSSLGNPQTSLTSFNNNITTALSSLNQPHYGKSTDLISTPSSTTVSTQHVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA11</accession>
    <name>A0A914ZA11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7080.t1">
        <property type="protein sequence ID" value="PSU_v2.g7080.t1"/>
        <property type="gene ID" value="PSU_v2.g7080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7080.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13544" checksum="A11B48D23BE73C2E" modified="2023-02-22" version="1">MLPLKFHELMAWINDVSIVIDVSDEEQNTLLNLLFSVQQNLDAVYKLIKETKGLIFKLPEIQQVYEKDIQEEEDCTNEDIDEEDCIDEIEEDSGNFEISDEDSDGDIEEEVVVEICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAP5</accession>
    <name>A0A914ZAP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAP5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8988.t1">
        <property type="protein sequence ID" value="PSU_v2.g8988.t1"/>
        <property type="gene ID" value="PSU_v2.g8988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="221"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8988.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="35860" checksum="FA2377DD612D31CD" modified="2023-02-22" version="1">MAQPQAPPPQPTVVQGRNAVTPEVEAAMADFVKTTLAKGVAGLRKEFAEIKVYTATEYKFEAFSNANNIPKNRYKDVVCLDGSRVVLNLNVPPESDYIHANLIKLEGLDRSYIATQGPLEGTIPDFWRLVHQESATSVVMLCKCIEDGKNKCAQYFPDANAYKNYGCMFVNNKKTEAGTAGEDKLVIHTIEALPEGCSNSTVVKLLQMNDWPDRGVPEKPMSVLRMIRAIPTGICVIHCSAGVGRTGTVILIDAIIHRLLKGQLCNVKEMFQTLRNQRASAVQAESQYVLIHTCVLEYIRAKLPGKYRESALQFAEEVKNAKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBE3</accession>
    <name>A0A914ZBE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9976.t1">
        <property type="protein sequence ID" value="PSU_v2.g9976.t1"/>
        <property type="gene ID" value="PSU_v2.g9976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036834429" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9976.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15183" checksum="B101715C692BFF63" modified="2023-02-22" version="1">MFHFILLILITFLSFIICTSIFCATKKQKVDGKTTSMDDPPSKKCNTKGGLLADDPDLKSLKLRAKEQKKAGGAAASLVTATKQSTLEGTDLKSLDDAGKKKEQQKVQTAITPLDQKAMSAYVNKTSVNQDGVSVTIFLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBH5</accession>
    <name>A0A914ZBH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dehydrogenase E1 component domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBH5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g928.t1">
        <property type="protein sequence ID" value="PSU_v2.g928.t1"/>
        <property type="gene ID" value="PSU_v2.g928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="7">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g928.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17272" checksum="DD55F12D9E9EAE1D" modified="2023-02-22" version="1">MIEAPIFHVNGDDPEAVVFAAKVATEFRQTFHKPVVVDMFCYRRFGHNEGDEPAFTQPLMYKEIRKHKTTVQLYSDKLIGEGLLTQADIDQMKAEWRDKLETEFEAGQNYKPNKADWLDGAWAGLRTADNADEQRRALPRQSLEDDRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC56</accession>
    <name>A0A914ZC56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC56"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9314.t1">
        <property type="protein sequence ID" value="PSU_v2.g9314.t1"/>
        <property type="gene ID" value="PSU_v2.g9314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9314.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31915" checksum="87EC2385E89609AF" modified="2023-02-22" version="1">MRREKFNVNNAFETTAIDSGTIWTTEEIPIEDRRHRRSSSPYRGEETNYFSSNPIGRPNAERNRGFDNTSANYGIPRPSYEPERQRTEISDEFRFLDDRPAFASKLGRFYPSQRFSFHYRKPIFIALAIIQIFLAVCLFIFAIIRFRRAFNVLNMIFAAFALILWFEPIILVAFELNLKNVQLQDQHRDTTYQLLIVGTSLMTFLLLFINTLSIIHAASQLPKPDETRSSLFDLHINMITIVLAVVTIGFSAYATSKSMTNVALWFVNNELNFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDF2</accession>
    <name>A0A914ZDF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8293.t1">
        <property type="protein sequence ID" value="PSU_v2.g8293.t1"/>
        <property type="gene ID" value="PSU_v2.g8293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057618">
        <property type="entry name" value="Znf_POGZ/Z280C-D-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24392:SF31">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24392">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25429">
        <property type="entry name" value="zf-POGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8293.t1"/>
        </source>
    </evidence>
    <sequence length="599" mass="68776" checksum="7B3EDA350CDDE1FE" modified="2023-02-22" version="1">MNDEGADQPMSSKSLTVNGKANSGLLSATISITNEKPLDLSLLFNLSETPKEISSSPPPEKSESVSSKVNPPIVSSRAFGSADDESMNSSPPVQNGIENKANGNTKFAINHKNSILTDGNRKRLLESREKSLLSTDKRSKLSTNLRKDMHGNGHYFVSEPNNRFVYQDADEFAGQFRCTSLNCNKVLSNNVSFMYHLWSHVGFFQKRDYSVESEDMTDEKFTRICSICLRMFETAFDKTKHYLEVHRGGTSANPFCHICEIVDYDGVHASNIKHRQNELPYECRRCKFRSSSRMALIDHFSKAHIGTTLLICPFCPYTTQITASERLKPIVLAKNYVNHVTEHGEIIAKKCSCCSYKFIDDEQFKKHTKCHQNEQHKWNVQTKHFKTLKDTALVTKPRHEMLSLLKCLECETIYSKSDDHFGKLRKCSNCSFESTCIKSYWNHKYLSECNPENKARFQFAVPKDDKKFVKPKCSLKVRKSLKVMTSPGYIQNFRLFRDFTFDRKPSKRPPPTKSKNDILKERREKLRQMTTARKTNDIPSQVLDEIANSVFGEKESNADTVNFAKQIRVPAVPFFEEFLKLKKQKLDEKEESDEEKEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE12</accession>
    <name>A0A914ZE12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g8519.t1">
        <property type="protein sequence ID" value="PSU_v2.g8519.t1"/>
        <property type="gene ID" value="PSU_v2.g8519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8519.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="41420" checksum="D99D50D9763CC82D" modified="2023-02-22" version="1">MNIQPDGKPINHEYSSGPETIKKPSSSPAAPAVEKSESAPVTSAPTAPEPNTEATVKLPQVPNDSGYKEAQQETTKFPTLKPEAPTSDSPKENVEAQKPETETETPEESLVVLNKASSEAAPTPPKEEIEKSAEKTKEVEKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEIEKSAEKTKEVEKVQTVPETYEISDITASSTSAPPAIKDKINNNLEVKATSNVNEYRVFGEKSNSQNAIEPSKIPEEKTLGKPKIALENNVIRLQVIDGGSDRSVGRKPIALPEGFVNIPINKEMEKALLEETIIPHHSVFEGKEKTKSEGEEKGKGLQGEGTQTRGFESSGNSNTNKNVKIEFSTSEPIQTESVPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHB3</accession>
    <name>A0A914ZHB3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZHB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9675.t1">
        <property type="protein sequence ID" value="PSU_v2.g9675.t1"/>
        <property type="gene ID" value="PSU_v2.g9675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="3">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9675.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35292" checksum="21AFA42019684661" modified="2023-02-22" version="1">MENTNNSATVYLHPIVALTISDQWTRRKMNSDDVHPKVIGYLTGKKDDLRLEVNRAFLLIFDERKMDDDLNALSFDEEFFKTQLELSKEMYPDEELLGWFTNGTHVKVTQVEEHLNRQFMKHNDCPLLLKFDTEHLQSTGRLNIGCFETVTDEADKSKTSFRLLPLHFETEASELIGLEHMASFSSSADYSHTSASKVLTSLTVSMEVFHHRLRVCREYIKDVMKGEIQSDPQVLSDIFKLCLRLKALKTHSSIDNQNLVTTSKQILNIAGLTALYEDVSSVSEILNNFFTESSAPSASHYRRLPAGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS76</accession>
    <name>A0A914XS76_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XS76"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10839.t1">
        <property type="protein sequence ID" value="PSU_v2.g10839.t1"/>
        <property type="gene ID" value="PSU_v2.g10839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1758" evidence="2">
        <location>
            <begin position="451"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10839.t1"/>
        </source>
    </evidence>
    <sequence length="693" mass="78136" checksum="95FA758C4F668B28" modified="2023-02-22" version="1">MSGAIRTALGQIRRYAKSHLDKYKVMLVQNPTPWNADTLTLFAATLEIFKNDLKKFEKNFEKWQEVLDLMEDDADRKDEQELFDVAYKSDENGELIDELETVVATINSHLKRTVSVPVVVQPGAPTPELNVVDTHSHSQTIPTLDIPKFKGDYLKWSSFWQRFDHAVHQKGFPEVEKLISLLGFLDGRALEEVEGFEVCGQNYKTVVQILTDRFGNKQLILKELQTKLRSIQPADGTVESIRTTVNTINNICLQLKNHGVNIDNDSLKLDIIEKLPKAQKDELTWLSVTDPGKTTEDILQRMKQMALKAEICSQSKPQLPLKNNQLLNEQKVLNKTQHSSNDQNQPLKKKYPCYLCEGDHFSSRCVKFPTLEDKLKQLKAQSRCTQCAGQNHNAQNCAAEIKCRACGGPHRAFLCKKKNDGVWSNKPTTSSNFVSVERSQSSLLTKEITVLNPNTNESVSTVVIFDSGSQRSYISDDLIKQLKLSTVNHERLNVQGFGAKASNYIAKLVMLRIKTSETFKDVYANSAKEIASKVPVVTFDVDDLPGFEVVHKKPDIIIGMDYFFEFITSFEQKGKMYIVQSIVGPMVGNFIPTAGTDTVTSLALEPSSNLDEDVQTFWKLENMGIKDIPKITDEDSLALKQFHDSVKFENNRYYVSWPVKPDHKLLPTNAGLAIGRLKSTLKKVTQDPILSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT59</accession>
    <name>A0A914XT59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA-processing protein FYV7</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT59"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10149.t1">
        <property type="protein sequence ID" value="PSU_v2.g10149.t1"/>
        <property type="gene ID" value="PSU_v2.g10149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01854">
        <property type="entry name" value="BR22PROTEIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10149.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14263" checksum="AB159BF7F1E85738" modified="2023-02-22" version="1">MPKSTENEIALDETPQDDEQSKPETSAKKSRKRKQTTPSDGLTAFQRAKKQYDKIQDDRREEAKKRRIENDRRENERLDAMGFRRRKDQAIKSRTKKGQPNLNALMGCIVEKLMKEKEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUS5</accession>
    <name>A0A914XUS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sec-independent protein translocase protein TatA</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUS5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10289.t1">
        <property type="protein sequence ID" value="PSU_v2.g10289.t1"/>
        <property type="gene ID" value="PSU_v2.g10289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002813">
        <property type="entry name" value="PRK02958.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003393">
        <property type="entry name" value="PRK04561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42982">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42982:SF1">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10289.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9794" checksum="DE4809E8C9EA9D30" modified="2023-02-22" version="1">MLDSLITNVTSVFMGSFSIWHWLVVLAIVLLVFGTKRLTSGAKDLGSAVKEFKKGMRDDDKPNAQLGDESRSQDASRTAQDEHDRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV22</accession>
    <name>A0A914XV22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XV22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10393.t1">
        <property type="protein sequence ID" value="PSU_v2.g10393.t1"/>
        <property type="gene ID" value="PSU_v2.g10393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10393.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="40498" checksum="21CD2ECD6AF012A9" modified="2023-02-22" version="1">MYDPKRIQEAIIFKRFAFFGIFLATISTFLLIILVPALYNYVQVIQSGLRDELDYCRHNADHLWDEYARVQRLAGPSATKLNKREYYNRIFRTKRDTGYDALEVVEATPKASSESAPAAPAAETSSAAAPAAAPTEVLPSSGADNAGYGGEAKPAAPAAPTAPAAPAPVNAEAAYDGKVPEKAPESSVSENVAGEAPAAPAPAPAAPAPVNAEAAYDGKVPEKAPESPVTENAAGYGEEAAKSEAPAPAAPVNAEATFDGSTRENATPAAPIEAPHMTMASSEGHETCSCGMGPAGPPGDNGPDGVDGVDGMPGDVGKDGTDAQPDEMPNESNMCFMCEESQPGPAGNVGPKGAPGNAGTDGEKGKDGTPGSLGPVGPEGQPGPAGEAGIDGNISFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXM7</accession>
    <name>A0A914XXM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12702.t1">
        <property type="protein sequence ID" value="PSU_v2.g12702.t1"/>
        <property type="gene ID" value="PSU_v2.g12702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037777883" evidence="4">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12702.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9918" checksum="2E5CED18A54D6224" modified="2023-02-22" version="1">MQIHESPPILFILLISVFLFPMQCFSAPTPEILQKRFPDAIIIGVKKCGTRALLEFLKLNPRVKAPGPEVHFFDKHYDLGYEWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXR5</accession>
    <name>A0A914XXR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXR5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10529.t1">
        <property type="protein sequence ID" value="PSU_v2.g10529.t1"/>
        <property type="gene ID" value="PSU_v2.g10529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44115:SF4">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44115">
        <property type="entry name" value="PROTEIN CBG09704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10529.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33360" checksum="BBD8B6509629E5AF" modified="2023-02-22" version="1">MLQRITRILFFQPLNTSLRFYSTKTMYDFKGKTVIVTGSSAGIGQSTAVRFAKEGANVTIHGRNPEGIEETKQKISELGVGEDRIQVVFGDTVEDKTLQDLVDKTIEKFGQIDVLVNNAGGSSKQEGYDKADISSLDHVLELNLKSVMKLTSIALPYLEKTKGSVVNVSSVDAHKPHPEALNYAVAKSALDAYTRNACCSFAEKGVRINNLNPGWIRTEIKKRGGTSEEGQKKFEETWVKKNVPLARSGLPHEMANIIVFLASSEASFMTGSLIIADGGLQNYSEPQGPAAKTDEEKKEEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY92</accession>
    <name>A0A914XY92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY92"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11501.t1">
        <property type="protein sequence ID" value="PSU_v2.g11501.t1"/>
        <property type="gene ID" value="PSU_v2.g11501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11501.t1"/>
        </source>
    </evidence>
    <sequence length="362" mass="42235" checksum="C0CEBD1CA7CC8CE6" modified="2023-02-22" version="1">MKLNDCDSIGKQVAWADMSRELMSSARLLPSYPLKYKDKFPQDATKINRTKFLKKDSQLPIWWFNGNYSKDNCTFKFIVKEIDVSGIQGESVYSQTGDKRYEGNIKLMKELYILHFFKHDNLQHAFFTRSEPKIFRMNIILPRSIPLLTVSTALKVQYHWKKCPSMPYVAVCILRAVAYLHARDIVHGNISIENCSYDSNGNVLLGGLNNIDRCRLEDDMINDIWRVGTAVLDFVLETNDNGIDFPDYLCIEGYDSLDDKFLNIPSQPRNNNAFNRADDRFTCIRRGYIRSLISPDSDLMFFFDRVFRSPKLGSYPTAEYLLKYHHYSAIEQDTFQELQKALLAKCRRRELEAEPFCRDRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYC8</accession>
    <name>A0A914XYC8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914XYC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10702.t1">
        <property type="protein sequence ID" value="PSU_v2.g10702.t1"/>
        <property type="gene ID" value="PSU_v2.g10702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07786">
        <property type="entry name" value="FGGY_EcGK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000007">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000008">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="19">
        <location>
            <begin position="275"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="20">
        <location>
            <begin position="515"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10702.t1"/>
        </source>
    </evidence>
    <sequence length="728" mass="79535" checksum="4916625D3DA61CE3" modified="2023-02-22" version="1">MPTSIVEDPIMSQTSTLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVIPFIVSQVAGAFCAAALVYGLYYNLFFDFEQTHHIVRGSVESVDLAGTFSTYPNPHINFVQAFAVEMVITAILMGLILALTDDGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLAGWGNVAFTGGRDIPYFLVPLFGPIVGAINKKLRCNMTTGQLNMTEKKYIVALDQGTTSSRAVVMDHDANIISVSQREFEQIYPKPGWVEHDPMEIWATQSSTLVEVLAKADISSDQIAAIGITNQRETTICRRTAEICEHLKRDGLEDYIRSNTGLVIDPYFSGTKVKWILDHVEGSRERARRGELLFGTVDTWLIWKMTQGRVHVTDYTNASRTMLFNIHTLDWDDKMLEVLDIPREMLPEVRRSSEVYGQTNIGGKGGTRIPISGIAGDQQAALFGQLCVKEGMAKNTYGTGCFMLMNTGEKAVKSENGQLTTIACGPTGEVNYALEGAVFMAGASIQWLRDEMKLINDAYDSEYFATKVQNTNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNANHIIRATLESIAYQTRDVLEAMQADSGIRLHALRVDGGAVANNFLMQFQSDILGTRVERPEVREVTALGAAYLAGLAVVWQNLDELQEKAVIERDPSRHRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYD6</accession>
    <name>A0A914XYD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12220.t1">
        <property type="protein sequence ID" value="PSU_v2.g12220.t1"/>
        <property type="gene ID" value="PSU_v2.g12220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12220.t1"/>
        </source>
    </evidence>
    <sequence length="533" mass="61785" checksum="0FE936AB53978E61" modified="2023-02-22" version="1">MPRGSREFSYFNREKNVRNGVVVECNWNKADYIVHTIADFTKHQCVYTLRSCFKTRQNPETRSQFYKDERPYEVFENVNFEADEYNLVPEKVARNQKKWECSNMGNDVFAVRDVCIFSRDTPRKCYSELAGIIVPYNDGIADEILTANVPFDCFLQFSFTPSNNVNLDNPAVFSLQYKVHSIEQVNPEQFGLAFKTPWLKFTQPVYEDYDPFNLGSDPEKLKLLPGIKGYALTGNKVYIPSRPRWSVSLAHNKITSLLKIHQCAQIKPHMPLLLDVRYNDNINRYIVYDATARGEKEFPATLTKDRFHQALLSPVPDCPGYFTFRDIGLVFDKYGRMVSFYSSDRQAKINADFTYVDPDERAYTQLEIRRVYDKNDIDLMAVTFEGFYIGNNEFYCPFLHFWILRAPGDMECSIGSWYRLKIDEIHEDEGIADVEAQILPQYDPVPHKMVQENIEFLVEIGVHRAAGNQILVAPYIGPIGITEIELARFENIKAVAIQFPLPEELREDRVQVRPQMTKTFKTFEQGKSVGGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZF0</accession>
    <name>A0A914XZF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZF0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11909.t1">
        <property type="protein sequence ID" value="PSU_v2.g11909.t1"/>
        <property type="gene ID" value="PSU_v2.g11909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11909.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="17923" checksum="CE907BD44376B9C9" modified="2023-02-22" version="1">MDQAALQQQNYLMMHAAASLAGAAGSSTGGSGGSGGGGGKQSSNSAAATNDIVAQIAQLQAILQFTSSAGSGVTNASFNKAIEDAMNLSKKDSAHSTPTTSTSKTSNLNASTPSSSQKVSTTSSMSQSQKASTSTASASTPSTSAASAAAALAYPQMNCAEAEAFEKAALDQLGIGFAELMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1B0</accession>
    <name>A0A914Y1B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1B0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13238.t1">
        <property type="protein sequence ID" value="PSU_v2.g13238.t1"/>
        <property type="gene ID" value="PSU_v2.g13238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13238.t1"/>
        </source>
    </evidence>
    <sequence length="562" mass="62197" checksum="3AA23A132616D942" modified="2023-02-22" version="1">MNINPLQATNYGPQPAVQALTGYGGQPPSAYLSQQQQQQQNVQTYYPFNSADNNNFPQPAPTPISSPQANIYSVPEQQPNQGYGGQPQQPDPVIYQPQPQQVVAPQQQVNNFNSYPQFPDPEPEASSQPTIDNTNLQQYAQYLDILQKQYGIKLPAAGGSPTSGSTIVVPNNMNEQQQNAAVQNPYAAAVQPQTQSHIQSQLQSSLQGIYPQQGAEHSWNPWQTNAQNNFNNQQQQQVKPIVTTYVPQQPPTAPQPQPQQPQIQIQQPQQQVVYGNNEVYQQPAPQPQPQQQPYYPTDFASSNTVVEPQPKQPQHPKPQPPSAPHIIFPSSIPIPQPRPQQPHVVVHPDVVPHTRPLPQQPKTPVYIQPTYPSILPSTTPLPPPPPQPSPTRSSLEYEREIVVATHPPPTIRAPAPTPTPSRPSSLPLTPSTTSIQALTQQIRRLPAVLYVDSRSPDARRTETLLRETYGLPLVAFYVDKIDKPKAVERHLHQLTAHKGLPYLFICGTFIGSQAHIDNYHANRQVPQLVEFVCSDEKKRKHKKKTSASKVAAAAATSAVVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1B4</accession>
    <name>A0A914Y1B4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1B4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1301.t1">
        <property type="protein sequence ID" value="PSU_v2.g1301.t1"/>
        <property type="gene ID" value="PSU_v2.g1301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037183876" evidence="1">
        <location>
            <begin position="29"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1301.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23400" checksum="2ECBE73976E7044F" modified="2023-02-22" version="1">MICWMVAQMMNQLHLFLLLLFTLSFVGSIDYHGNQRFWTSVNNGKTNIGLHVLTEPIELFFPKNKTFAQLASDIKLYSSAGNGQCKDTTHSLNFTLTVTEQSYNIGQIKFDFGDLMAFLYETCVLNGNEYKGRKYISLQMGDNPVNLENPGRRCFKNVAASFQVYDKDTSKHVMKLEASGSIECQIFMELVFYFSIYSFLPVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y249</accession>
    <name>A0A914Y249_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y249"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14255.t1">
        <property type="protein sequence ID" value="PSU_v2.g14255.t1"/>
        <property type="gene ID" value="PSU_v2.g14255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14255.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11779" checksum="2E001A78A9755413" modified="2023-02-22" version="1">MTSTVYRERSQDSVIVLSDSDGEKEEKCLKIHYQESLEFFEIPMESDGRISLEDVISMDPKIFALIVQKDGYRKLVKPKNGYWKEPKEKWKNFKVFFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2A6</accession>
    <name>A0A914Y2A6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2A6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13372.t1">
        <property type="protein sequence ID" value="PSU_v2.g13372.t1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:diacylglycerol binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Unc-13"/>
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        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13372.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14463" checksum="99B5A2C8B5E22EC0" modified="2023-02-22" version="1">MATKSKNNDWAPKFNETFHFFLGNEGEPEHYELMFQVKDYCVFAQDRIVGVGVLQLAQVIEQGNISTWIQMGRRLNVDETGLILLRILSQRQTDEIAKEFVKLKSECRHETESTLAASASSQQINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y331</accession>
    <name>A0A914Y331_9BILA</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="WBParaSite" id="PSU_v2.g13860.t1">
        <property type="protein sequence ID" value="PSU_v2.g13860.t1"/>
        <property type="gene ID" value="PSU_v2.g13860"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037387452" evidence="2">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13860.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="11860" checksum="BA3A439F622B028B" modified="2023-02-22" version="1">MFVLVIFALAALAAAKPELGLGLHGDTPLGNVGTNAGVGGLGGHSSEESGEHGHGRHIRQSGQGQNGSGGQGGSGNSGQGGSGSGGSRQVRSGGSGGQSGSGGQSGSGGQSGSGGVIKVDKVEKVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3J8</accession>
    <name>A0A914Y3J8_9BILA</name>
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        <submittedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3J8"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="AA_transpt_TM"/>
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    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13349.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21359" checksum="6E239BC87D90F9AC" modified="2023-02-22" version="1">MKRPSEFAKSTILAFGIITIMYVPVCIMGYITYGDSLRDSIINSIQNSTLQQAVNIFITIHCILTLTIVFNPLNQEAEEILNVPLKFGYKRVLVRTTTMAAVVFIAESVPKFGPVLELVGGSTLTLTSLIFPTVFYIKLSALSKRNQKEQQKIEGEILKCEEMAFSEVIKWTPKVMLICCIFTSGKQYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y407</accession>
    <name>A0A914Y407_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y407"/>
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        <property type="protein sequence ID" value="PSU_v2.g14928.t1"/>
        <property type="gene ID" value="PSU_v2.g14928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14928.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13078" checksum="B9DDF3DC97A2C235" modified="2023-02-22" version="1">MVGTQALEAGFGHRTDVLRAAVQAGIDARILEAELGGDHQLVAIRRQRFTEQVFVGVRAIHLGGVEEGHATLDGGLQQGDALAALHRLALGVGQAHATQAQGGNLQATAAEFTFLHRRAPEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y499</accession>
    <name>A0A914Y499_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y499"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15023.t1">
        <property type="protein sequence ID" value="PSU_v2.g15023.t1"/>
        <property type="gene ID" value="PSU_v2.g15023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF141">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15023.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14831" checksum="80FB22240667F576" modified="2023-02-22" version="1">MLLDGALRSMILPFNRQKSAIIHSFRPHYILPINTDSFFRYEGSLTTPPCEESVIWTILSEPISMTKIQLGLFRAIRQNDGSEIKDNTRPMQPLNGRPILYQSMKRHFKFCDLSNPFVKALGQRICQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5U7</accession>
    <name>A0A914Y5U7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5U7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15572.t1">
        <property type="protein sequence ID" value="PSU_v2.g15572.t1"/>
        <property type="gene ID" value="PSU_v2.g15572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15572.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40906" checksum="07E26F55FD36192E" modified="2023-02-22" version="1">MSVALDRYFVICHHSLVNANINDHMTMPVCIALITLIWTVSLSLVMPYAVHMRLAYVHKPCHYFMCIEDWSQAGLKSVYGIVVLALQFIIPFAIIFLSYQKIWSFLNKRFKMVVVERGGDKKKDNKKRKRLLRMLITMVFVFGFCWFPVNALNVFRDFYGVVPMRPYFNYAFLTAHMVSMMGTAFNPILYAWMNESFREQFIRTVPQLRWILSKNRRAATRQRIITDCAPATNRVNCGDRVNGRQKLNRPLDTKNKTLLTTTSIPDFADPVSNEEEEEAYELRSLEPSTSHFNENHKGNNYHNGYRKTSNFLTIPNGDGAPGSSKMRSTSNSDVSCSLDESRSLLSDFSNYDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6B9</accession>
    <name>A0A914Y6B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6B9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g132.t1">
        <property type="protein sequence ID" value="PSU_v2.g132.t1"/>
        <property type="gene ID" value="PSU_v2.g132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g132.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="14409" checksum="C9391DE7101C616B" modified="2023-02-22" version="1">MGCATYPIAGLYRLAALDCRCGTECGCAADAGHSKPAYPCALAGPVPAGNCTDGWSLRAVVQCHQATGRRHCCPLHAAGACDRFYSGRADQGHLAHHTATGGSGTGHGWTGLEPANTGRRTLHAGSICPQALNAPPKEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7A0</accession>
    <name>A0A914Y7A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7A0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16088.t1">
        <property type="protein sequence ID" value="PSU_v2.g16088.t1"/>
        <property type="gene ID" value="PSU_v2.g16088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF405">
        <property type="entry name" value="PROTEIN CBG12249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16088.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12434" checksum="F1C4A540902CCCE0" modified="2023-02-22" version="1">MQHEPLKNNFQQPQCHRIVTGNETLSANSGYKGTFTWSVEDQSLLFSAGFYGNLIIMAFAGFLINHFGAKKVALISAIGMTATTALMPTAAYLGFYYFFVLRILFGIFEASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7P1</accession>
    <name>A0A914Y7P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7P1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14762.t1">
        <property type="protein sequence ID" value="PSU_v2.g14762.t1"/>
        <property type="gene ID" value="PSU_v2.g14762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14762.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11347" checksum="0CE77C3469C84640" modified="2023-02-22" version="1">MKDLDQIKLNVGGHKFETSADTLKTCESFFSTLVTSDIPQKVDADNYVFIDRNGVNFGKILDFMRMRTIDFGHNIELAKAIRVEADFYQFQVRIIVGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7T8</accession>
    <name>A0A914Y7T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7T8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15339.t1">
        <property type="protein sequence ID" value="PSU_v2.g15339.t1"/>
        <property type="gene ID" value="PSU_v2.g15339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15339.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9344" checksum="30400CE20F30E856" modified="2023-02-22" version="1">MIIDSLHTHYESRLKTLEAMLTEDDATEVHVAMNEADNNETPESQLLSKQLTDATTAVLKRIETNNEEKKSVLEELTAANSTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7V4</accession>
    <name>A0A914Y7V4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="10">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y7V4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15355.t1">
        <property type="protein sequence ID" value="PSU_v2.g15355.t1"/>
        <property type="gene ID" value="PSU_v2.g15355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="11">
        <location>
            <begin position="274"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15355.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37524" checksum="F5AE0D141C7D5D4E" modified="2023-02-22" version="1">MKDFRFYPYICDAVRDLALESTEEEEAKSLLRRKQIFVSFKEVPNKEAVRELHSYKVGSLVRISGQVVRTHPVHPELWRGTFVCEECGVTIRGVVQHFRYTPPNQCTNQQCQNRTRYSLDIYESEFVDFQRVRIQEIQEELPRGCIPRNVDVILRGEAVEKVQPGDHVDFTGMLITIPDVSVLSAPGIRAEPKNMRKGKGGGGGDAGGLSGLKSLGVRELNYKLAFLCTGVQPTIQMFDEITLKPDTTDFTETWASLSAADRKTLMDMSSDKELIKHMRDSLFPNIYGNDDVKLGILLMLCGGVQKHRPGTTLRGDINVLLVGDPSCAKSQFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8J3</accession>
    <name>A0A914Y8J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EXPERA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8J3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15070.t1">
        <property type="protein sequence ID" value="PSU_v2.g15070.t1"/>
        <property type="gene ID" value="PSU_v2.g15070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15070.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24758" checksum="E64840D0B953509C" modified="2023-02-22" version="1">MGTVVDLLKRWDRPQRGCQLPLWVEIWLGISAMLCTLDVIYTMLRPLTNRGGPLECVYELWNWYADVDLRYATANDLVTMATGRVMIIEIVMNLVSMFMNRSGSKHTLITAFTTNAFVFWKTVVYMALYISPADGNPSYINPTATTYDIIVYFWIPDGIWLLMPLIVLIRLWSELLVYPPGLLSDNPTPPTGRSAYYYTKASNIDDNMSNSGIHLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8T7</accession>
    <name>A0A914Y8T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8T7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15167.t1">
        <property type="protein sequence ID" value="PSU_v2.g15167.t1"/>
        <property type="gene ID" value="PSU_v2.g15167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15167.t1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36231" checksum="A5F236DA20312687" modified="2023-02-22" version="1">MKNPPETVQREEEETEHPSKRSTNSDPRPVDPAFVPPKSRLHDDDFGRTTAAAIKRKTSDLKEKESSSTVKDATSTKSVGFSTSSSAETNSSQSLNNDNRNILKSPPPPQELTSEEEDESEMHICPPRNLNYYSRFASKEKAVVSPQNDERNADEHLLDSDNEESSDVVIPESQDRLENNTVLSQNDEEDNDNDVPQYPPRNLDIYKSLSSSSNATSTSIQPVIRRSVFDDVSDEEEIPSDRQKKIVFDEETAADNEHVPKKIDPYSGNSRGSALQPHETIDKEHKVNMEGPNPTRLLTAFPNQMGPCHKPEVCSFCQVFLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y905</accession>
    <name>A0A914Y905_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y905"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15754.t1">
        <property type="protein sequence ID" value="PSU_v2.g15754.t1"/>
        <property type="gene ID" value="PSU_v2.g15754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15754.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28123" checksum="7DCEC6C21018B44E" modified="2023-02-22" version="1">MTFIYLSIFFITIFYQSYGQLRTRPRGLGLLKLPTGIADERSGPFFPNIYIAGDKPGTRPQTVPDIHLPGQTAIFSKRTAFNPFTHAVSAVYTEDITDSWGAGFAVNGVNNYNLKIRQNFDEYASAPLIANDGGHQPLISAFAVGGEYDLSKIREVAGHVDIPLIGINELFDFDGRLMGKTFGNGVLNSNIDFPLSLSDSQERFPAAFNYLNFMADRHMHYGHVVPNVNLFLINKNKIMEKLSQNKLNPTILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9T6</accession>
    <name>A0A914Y9T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-GEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9T6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16044.t1">
        <property type="protein sequence ID" value="PSU_v2.g16044.t1"/>
        <property type="gene ID" value="PSU_v2.g16044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF327">
        <property type="entry name" value="EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="286"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16044.t1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53835" checksum="DFC8EF0B8D85C8D2" modified="2023-02-22" version="1">MAGLPEKMIEYVLETRIDAQTDDISLDTFLEDFILTHIIYMPSNILCNYLKNYYSRRGSMPYSSNGLMPSSVETDFDVEQQFIAKRRVIAFLSIWESVFGIHFFLDTVANSFVEEMYCCVLEDSKRIPNMLPILDQITGLRQLRENAMRVLSRHPTTILDCGVYSAQAPAPDPILSMDTCNQCIYLSDTTFITMSIRLDKNASEIADLARCKLKCASTHEECFLIEVKSSGERVVFAPTEVSVPTMLSLNGRLYVVFKDEIDSLTPLSDQQGPIDGMYHSILDLMGSSEIAQQLGIFHTHLFDATDEIELIFQVIGRDQFSGRMPSNLDILLRRFNEVQYWTTTEILLAAPSKRVVYLKKLIKIASITKENKDLMTFFAITLGLSNLAVSRLTSLWDKLPTKLKRQYGEFEALLDPSRNHRAYRMLIAKITPPVIPFVPLLLKDLTFMHEGNKTYFAGLVNFEKMKFSRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBJ1</accession>
    <name>A0A914YBJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16135.t1">
        <property type="protein sequence ID" value="PSU_v2.g16135.t1"/>
        <property type="gene ID" value="PSU_v2.g16135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16135.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24789" checksum="64E2735BE79B989D" modified="2023-02-22" version="1">MKPENVTLDAKNEKELEQIKTVNHKPFQPDNHWGFEEAPPLKPDDKLLPEPTTQKNQTFAEAQEQQSQNYLRNETENFENEKENFDFELPKPPEEPEIKYPPALPNTHPVANEQTGLLSGIGNVNVGYGVGVPVPGSPDGVSVGARVGVGLGGSGPAWKIPYFFNNQGEYQSLNDYDGDKRNIVPDRAIKYYRYQILQARERSRQQSHSINSEDESGKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDV7</accession>
    <name>A0A914YDV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase F1/V1/A1 complex alpha/beta subunit N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17484.t1">
        <property type="protein sequence ID" value="PSU_v2.g17484.t1"/>
        <property type="gene ID" value="PSU_v2.g17484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17484.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11675" checksum="041C0B50D768259A" modified="2023-02-22" version="1">MDISKNIQSSSKTMATTTAPVDVNKSITDHKTATIRNYTTQPRLTYKTVTGVNGPLVILGDVKFPQYAEIVQLTLQDGTKRSGQVLEVTKNKAISCIRRYAWPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDY0</accession>
    <name>A0A914YDY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDY0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17636.t1">
        <property type="protein sequence ID" value="PSU_v2.g17636.t1"/>
        <property type="gene ID" value="PSU_v2.g17636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
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        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
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        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
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        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17636.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16034" checksum="12BE012885253706" modified="2023-02-22" version="1">MVKEELLKDFERQLDNLKINHTIMIEDVEKAISKKAEESAKYQRYKLYRDAPNTRISFNLARYHSFAETINYLNALAITYPDRVRVMPIGTTHEGRQIPMIKIGTRSRADKPGIWIDGGIHAREWISPAAVLYFINQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE44</accession>
    <name>A0A914YE44_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE44"/>
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        <property type="protein sequence ID" value="PSU_v2.g17030.t1"/>
        <property type="gene ID" value="PSU_v2.g17030"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17030.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28476" checksum="603E35A3002E87BC" modified="2023-02-22" version="1">MDFPGILCEEVGVTCDPKISFVSPQALFENVSDMKGGGSYMEGPPRPSAARQNIEHEEIVKLGPLHMEYKDDVDGKEHECSRFNVNKSFNKADGQLMDMNIEVHQECDAVNAQGIYKRCVTCCLPTFAPESLAELNDDAKCVDMVNMIGRNDILNAFDENEQFEGFANGGRRRVVETPAVESQDDDIRPLVNVRTQVQNYTLAAAEAYQNLKDMVDTANEDFKNMNHAKKMISADLIQSCMVIVYPRCKRRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEB8</accession>
    <name>A0A914YEB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18601.t1">
        <property type="protein sequence ID" value="PSU_v2.g18601.t1"/>
        <property type="gene ID" value="PSU_v2.g18601"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18601.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22760" checksum="BDCC90260B59FD73" modified="2023-02-22" version="1">MGRDRSRSPSRHRKSKRSHRDPSPDRDDNRHSRKTKAEQGIDAAKARLREKLSTAITDLRDPKYTASSTETVDHHRMQTLNLSAAEAKTRQDAINDIESSGFAPASFSSTRKGNSHNLSKPSSSLSDHEKAMFGADWQSKALQKNLNIDEKKQEDDDIVEIPSEPIFSLAHPRFSEDPQIRQDRWLQLFKERRKELLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEG6</accession>
    <name>A0A914YEG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEG6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17148.t1">
        <property type="protein sequence ID" value="PSU_v2.g17148.t1"/>
        <property type="gene ID" value="PSU_v2.g17148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17148.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22721" checksum="940FDA80E16F09E7" modified="2023-02-22" version="1">MGYVSSLGGIAVDYNSQDVKDQLISEGPFDVILDCVDTDLARWSDKVMGVWRNCVHVSLVSPMLRDTDRYGIPFGLLSTAVKYFDRSCRSFRNGRWFSYAYFMPNSQCLNQISDFIDNEKIKIPHVEKVYKFNEFPTAYDRCTLLHTKGKLIIDIAEEPIPPKIESPPPSSTISPYHPGTKSVPVIDLKPPPIHAEPAPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEV9</accession>
    <name>A0A914YEV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEV9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18805.t1">
        <property type="protein sequence ID" value="PSU_v2.g18805.t1"/>
        <property type="gene ID" value="PSU_v2.g18805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002603">
        <property type="entry name" value="ET_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01684">
        <property type="entry name" value="ET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054209" evidence="1">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18805.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15069" checksum="8F29D0B58006AE54" modified="2023-02-22" version="1">MKKLIFVLILFFSIISPIFCDSTNVKCFVGFAAGNHDPYVTGDELDCDGSCANLTLNVYNTAMSIFFCDSENLCDKLIESQNACKFVIIGLSMCCCRNETYCNIKNTFNYPLQQLPLKYLDIIQNVMEIAQILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHG1</accession>
    <name>A0A914YHG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHG1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18904.t1">
        <property type="protein sequence ID" value="PSU_v2.g18904.t1"/>
        <property type="gene ID" value="PSU_v2.g18904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF18">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18904.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8853" checksum="1CF0CC7F9E340D96" modified="2023-02-22" version="1">MSIFAVIYSLIVTLGILGNTLVILSVMRHRSLQSVRNMFIVSLSCSDIVVSIVSGTITPISAFTKVWIFGGALCKLVPLIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHI5</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19790.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11660" checksum="F2B465AD933B710C" modified="2023-02-22" version="1">MSSDILQASLFYFLQIRVEKKRHHKIPPDVVAIGKKEIAVIKKRRLMKEENIPQLKSILVKPDRSERTTIKCAKNKKTNFTGSNENQKTDGSLKSKKVKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIE0</accession>
    <name>A0A914YIE0_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIE0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20101.t1">
        <property type="protein sequence ID" value="PSU_v2.g20101.t1"/>
        <property type="gene ID" value="PSU_v2.g20101"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20101.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8631" checksum="4C4C0A432B9DCCB8" modified="2023-02-22" version="1">MQRTKRTMLEEDICLIELAGSSEDLESMSDENVLTEFQEAEITVVTESEPVIPVISDSPATSSRASNISNAATKNVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ41</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="WBParaSite" id="PSU_v2.g18851.t1">
        <property type="protein sequence ID" value="PSU_v2.g18851.t1"/>
        <property type="gene ID" value="PSU_v2.g18851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18851.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13210" checksum="B48FE60A465DBAA1" modified="2023-02-22" version="1">MLKDLLLRPRDPDSTAVDLDYVDHMIEIITKPENGIEELGRNNELFEKIFLNQSLIQLRSFFDRYDSHAMRASADSDSPKVRDFETAVRKSVNMHSDIRHMILLFGKDIFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJA6</accession>
    <name>A0A914YJA6_9BILA</name>
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        <submittedName>
            <fullName evidence="14">Peptidase A1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJA6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1893.t1">
        <property type="protein sequence ID" value="PSU_v2.g1893.t1"/>
        <property type="gene ID" value="PSU_v2.g1893"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000058">
        <property type="entry name" value="ASpartyl Protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF45">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="34"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1893.t1"/>
        </source>
    </evidence>
    <sequence length="376" mass="40950" checksum="D962784CB6235887" modified="2023-02-22" version="1">MEYYKQKEFFRRQISPTNFKSISQKIFDNDDIEYIVNVTIGTPEQSFRVLIDTGSSSFWVPDKTFCSNSSSSCPNYCSEGSFCEFLCNPSCCTSCTFNTGGCSNISVFDSSKSSTYISTGKNITLGISAILGEDIVRFGGVGTQQLVVPKTLFGQALYPSILESNDFDGIMGLGFQSNVSNSITPPLINAINQGLLDKPLFTVYLEKQGLAENVLGGVITYGAIDTLHCSTDITYHPLTSTNYYQFKMDSVSVGSYSSNEGWEVTSDTGTSFIGGPATVIDSMAKELGGIYDSYYGVYSVNCSADIGPVVFTFNGIQYPVDGKQMIINIDNGKCALTLFSLNSIGQQWIFGTPWIRSYCNIYGIGDKNIGFAKVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJN2</accession>
    <name>A0A914YJN2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJN2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19729.t1">
        <property type="protein sequence ID" value="PSU_v2.g19729.t1"/>
        <property type="gene ID" value="PSU_v2.g19729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008533">
        <property type="entry name" value="DUF815"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42935">
        <property type="entry name" value="SLR0930 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42935:SF1">
        <property type="entry name" value="SLR0930 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05673">
        <property type="entry name" value="DUF815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19729.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11629" checksum="F0DC371423567518" modified="2023-02-22" version="1">MPEYMKENLSASTSADGEIHPGEAVEEKVSLSERFGLWLSFYPFKQDDYLDIVYYWLGALGCPAEHIESSRMEALQWALERGSRSGRVARQFARDWTARHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJZ3</accession>
    <name>A0A914YJZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g1919.t1">
        <property type="protein sequence ID" value="PSU_v2.g1919.t1"/>
        <property type="gene ID" value="PSU_v2.g1919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1919.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30630" checksum="2FD46904363561AB" modified="2023-02-22" version="1">MPXXXXXXXXIGQPWFLGDIGREKSVELLNQVQEDGFFLVRYSSTNQNAFVISFRAEGIIWHYQLKRNGRLFVVNDKPFESLNSVVDFYGQNAFVHGATLRTPVNCSNIDQLAAKNLSEIFNHYIYQLNPDKAIAIKSFEGPDSNYLSFPVNVEIAIISKNNNYNNMWRGVYNSKCGLFPPEAVKEIGSNGKMKKVDKDGYVVIKLANAAVEQLKRPRQHCINICASGKEWTIAADDESDATEWFKELVNQTSFATLKEKKEQNAQDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKC1</accession>
    <name>A0A914YKC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADF-H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YKC1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19319.t1">
        <property type="protein sequence ID" value="PSU_v2.g19319.t1"/>
        <property type="gene ID" value="PSU_v2.g19319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19319.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10643" checksum="4C014C9F88A65AFE" modified="2023-02-22" version="1">MASGVKVDSACKQAYDDLHNRHLHSYLIFRISDDDTTIIVEKKGDKGAPYSEFVEDLRKAVGSGKECRYAAVDVEVSVQRQGTDGNSTFTKVVFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLA1</accession>
    <name>A0A914YLA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLA1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18097.t1">
        <property type="protein sequence ID" value="PSU_v2.g18097.t1"/>
        <property type="gene ID" value="PSU_v2.g18097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052499">
        <property type="entry name" value="C.elegans_NHRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630:SF6">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18097.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15833" checksum="2D2A10920A6A2FFE" modified="2023-02-22" version="1">MLRKIIDIYYTHLIRPFMEVSYAMPDEEEVALAMTIMLFQFSEVLSNEGHVICKSYKEKLFSALFEYQLSKFPEKSDSERIQRYAQLLEMMQRVTKVWSIESDIHLILSTFDEMNIDGIPKDLLFNRYLTKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLL6</accession>
    <name>A0A914YLL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18212.t1">
        <property type="protein sequence ID" value="PSU_v2.g18212.t1"/>
        <property type="gene ID" value="PSU_v2.g18212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18212.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25332" checksum="6F3AFB79AF43C09F" modified="2023-02-22" version="1">MADSGRNHRSRRHYDPRQADFLKQAYATLGTSELRNAVKLPQGEDLNEWLAVNVSDFFKQVTMLYGTISDSCTIYTCPSMTAGPKFEYTWAENDQSILCTAPEYIDYLFTSIQDELDDENVFPSQIGKAFPSHFVKIVQTIVRRLFRVYAHIYHEHFELIKSLKSTEHLNTSFKHFMLFVQEFKLIDTAELGPLHSLIQELIPSMIPDYAINGTSSSSSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLQ2</accession>
    <name>A0A914YLQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLQ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21259.t1">
        <property type="protein sequence ID" value="PSU_v2.g21259.t1"/>
        <property type="gene ID" value="PSU_v2.g21259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21259.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7983" checksum="6A2D109EA243BB94" modified="2023-02-22" version="1">MSGGFSAYGNPNQSNPYQSSANPFQGGNPFQNNNQFEQKWKNGRWEFTHRKNNPTGQTFTQDDFERVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM82</accession>
    <name>A0A914YM82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20030.t1">
        <property type="protein sequence ID" value="PSU_v2.g20030.t1"/>
        <property type="gene ID" value="PSU_v2.g20030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20030.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20320" checksum="9466D2B095296EB4" modified="2023-02-22" version="1">MSTTRNMIFIVHDIVNMSEYNIQTSKWKNFEFNRDIENYDPTQIFAQIQSATNLKKIKAMVFTIMDLCFPTIAHAYEFRLKCSEFCKSNGILYFYIPVSSIIAFSVMSKAKVMNALVIREESHFASIHNVIVEKVMHVLGDKITPYDVTIQCLSKIAVLMDEVLLINVEYIKALPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNL1</accession>
    <name>A0A914YNL1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysophospholipid acyltransferase 5</fullName>
            <ecNumber evidence="16">2.3.1.23</ecNumber>
            <ecNumber evidence="17">2.3.1.n6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.23" evidence="16"/>
    <dbReference type="EC" id="2.3.1.n6" evidence="17"/>
    <dbReference type="AlphaFoldDB" id="A0A914YNL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21001.t1">
        <property type="protein sequence ID" value="PSU_v2.g21001.t1"/>
        <property type="gene ID" value="PSU_v2.g21001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF14">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21001.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20618" checksum="22D101F62222AC79" modified="2023-02-22" version="1">METAQYDITWTTPMCIMTLRYIGLVMDVYDGQKPKDKVKPEMMKTAIPNPPGFLEIAAYGYFFAGTFVGPQFSLSRFRSFVNGEYLENGEVRQSSIMVSIRRFVAGVVYCVFNQWGAVWIPDSFFNSQEFFNLPFVWKIIWNTLWFRATMYRYAMAWCITVCLFLINILWLILACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNV3</accession>
    <name>A0A914YNV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19033.t1">
        <property type="protein sequence ID" value="PSU_v2.g19033.t1"/>
        <property type="gene ID" value="PSU_v2.g19033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19033.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19740" checksum="34FC0D46BD5155A4" modified="2023-02-22" version="1">MFCGTLEAAADARWLCENKISYLINLTGVSRIKIRSCSCADTLYHSPIEYIPKFNSDSTYKEITTEFHKINDFIQEARSKNACILIFNNDGYDLCQAIAIQYMMDYYGGLMLHHISSLQMKVKVKVKISPEYLEVLSFWEKEIEKKNPRISNNKSLRSFSFKINRKLAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP29</accession>
    <name>A0A914YP29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP29"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2603.t1">
        <property type="protein sequence ID" value="PSU_v2.g2603.t1"/>
        <property type="gene ID" value="PSU_v2.g2603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2603.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20414" checksum="4505C32EFE74044B" modified="2023-02-22" version="1">MCITIVQMRIENQYMNALQLIDEEARNNYGSTMQIGEPEAVSTELQETVETPLSLKANRSLTITGAGNPGVKWRRPMLNFQLHATTEDPRQYSQESDTAYTPNSCDSDVNRSNMYRMPSTSTLSGTGSAIISTPPVLNALISRQRSIKRFKQSPLMREDSMRSNYHERFDDNETTPLTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPX5</accession>
    <name>A0A914YPX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPX5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19416.t1">
        <property type="protein sequence ID" value="PSU_v2.g19416.t1"/>
        <property type="gene ID" value="PSU_v2.g19416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20065">
        <property type="entry name" value="FH_FOXP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047412">
        <property type="entry name" value="FH_FOXP1_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19416.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32165" checksum="BB059B646F217F92" modified="2023-02-22" version="1">MNPSQPASRSSASSSNASNLAMPSSSRRRVSDKAVMPISADIERNREFYRSHDVRPPYTYASLIRQAIMESRDCQLTLNEIYQWFTETFAYFRRNAATWKNAVRHNLSLHKCFARVEQNVKGAVWTVDDSEFYKRRPQRTSSARSSVKAATPSLDQNALVHALAQAQQQLNNELLHAGTNGGNINIKEESQLFNTHDYLKHSKDDLDLDAGHLSHRAAAPTSRPISAGPSSTIKREPLSPNRGSDPNNSPQLIVDDYDDDDDDDGVEDDEQHNSNENLMNSSKTCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQL5</accession>
    <name>A0A914YQL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQL5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2471.t1">
        <property type="protein sequence ID" value="PSU_v2.g2471.t1"/>
        <property type="gene ID" value="PSU_v2.g2471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2471.t1"/>
        </source>
    </evidence>
    <sequence length="478" mass="54110" checksum="13E395052701BF70" modified="2023-02-22" version="1">MYILARGLTEDSDKVLALLQCIGTSTLEKIIDWTSPDKPQAKSYQQLIDLLKEKFSCKKNLTALRFQFFTEKQHPGQTLQEYLAYMTQLYGQCSMASMKPAEYGVLAILQGLASDELRQYLMNPGNKIDDMSKVQDLALNFEQSRNAAKAFKGVDGQIKPYAMNVIGKGMKCRYCGDGHQRGKENCPAKDKTCSKCGKKDHFAKVCRSESTKQQNFVERYPNESERAESLNGIYGVLTVSSRFENSHPPFTVAAKLNGVTVAMQHDSGAAVSIIGKKVWHTIGKPRIYPSSIQLRSYNKLIPVIGQCKVIVQHERQIKQQWVIVVPQGESLFGRNWIQDFNVRLQRHCNTSKDQKGDECIVYKQHTVATGYPSFDRQAAKDIDKSSCLQNTIINAKQMHDTMQGKENKAPGKHYRCFNAFKKPKVTVACERHSQKQRHGTTQIHRREVNVITECDASQEIHGREAEDCEEDLLTIWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRW4</accession>
    <name>A0A914YRW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRW4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20138.t1">
        <property type="protein sequence ID" value="PSU_v2.g20138.t1"/>
        <property type="gene ID" value="PSU_v2.g20138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20138.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11744" checksum="29D13AFF770C7218" modified="2023-02-22" version="1">MRPNEARITPSFEFCFKELLVQFHRSAVENIVFCFPQTSGFNFEVGQTLTPLTVLLDQIEKKQQITIPKTDERMYAFDNMAYRYLCAVKQVSYSNYSELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS01</accession>
    <name>A0A914YS01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20169.t1">
        <property type="protein sequence ID" value="PSU_v2.g20169.t1"/>
        <property type="gene ID" value="PSU_v2.g20169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20169.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13492" checksum="FCB9B2EC6EED5F3E" modified="2023-02-22" version="1">MLQRRPNALEGLEQQNERRLLRESTLPTPIDEPKKIIRCHFLGVTQVPRATGIDILNEAVDRLVNQVRPERWILSDVSIAPSTITINEVGGGQIAQCRVRYLSFLGIGQDIKYGKIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS84</accession>
    <name>A0A914YS84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2514.t1">
        <property type="protein sequence ID" value="PSU_v2.g2514.t1"/>
        <property type="gene ID" value="PSU_v2.g2514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF19">
        <property type="entry name" value="CUTICLIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="74"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="191"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="486"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2514.t1"/>
        </source>
    </evidence>
    <sequence length="845" mass="94865" checksum="E8BD7883DABD3292" modified="2023-02-22" version="1">MSSWSTYVTIGAMSLRNCMRECIDSTVMFCRSFEFDKTNDECFLVEESSEMSIPSATIDLYEPICLSNTIDIPCPGDNVFERIPNVNLVADKFIKHVKGPKVDYCMDDCLNDDECVSIVYDKVAKTCKLYAANRSVPLAKTASDVTTDLYELACDRSAVLKEARKTTLSAQRRETKAVLRSSSIEPPDDPCGAKLLENDRTLRLEYRNLHHVNVKTQSQCKELCMTARINCATFGYSDDTKDCLLSTTVVEKNEQYDMITQPKQGYNLYAYMGYRLGSVCHPESTTTSNIREQFFTTAPFTQFTNPTLYSQVLQTTPFLQHPHVTTASKIETTIESINLAENAFNFDSKWFDITKQKPNGTSSSEDFDSGSTPFNEENFLFESIANSVPATTPLNRALSFTDSPATISTSTEKINNLQTFDRFNGKKKFFDPKNSQVKTISDGGKHDFEANNTLFGLPDKEEIPRRLMETSEIRRVNISNVELSAICLDHGINVTFMTKHQYYTGAIYAAERFSQCRILVENKKEFSIFINRPSENNWCNALEVDNMMTVVLVMSNDLVLPFDVTTKDDLFYQITCDYKDEPEMALIHSGVIVGGPEPKSVVSSLRHEDQPTKVALRILKDEHPVNNVFIGEKLTALVESEVNTTRVLVTECNATRVGGREPRPNSVQLIVNGCSLMPQIISNMFTGNHGLQASLTAFRIDGSDQIDIACNVVICRRSCERKETCENVVKRHRRGASFASPNPIDILSSDTSFEDMVTVDQRLRVMVDNEDSNDDIKTSAEAGKNGSCLDPVYLLIVLGLFLLSVIALALSVFANRCHQREMSDTESFGHVEPIRSIPRLKRCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSH0</accession>
    <name>A0A914YSH0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2600.t1">
        <property type="protein sequence ID" value="PSU_v2.g2600.t1"/>
        <property type="gene ID" value="PSU_v2.g2600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2600.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14213" checksum="97FA81622144A82C" modified="2023-02-22" version="1">MAEKLTLGETSLFELEEEIGEESKEDSFEKFRRELRTMLYAFGDVKNPHEATLDLLYSIMVEYITSVAKIGQSLEPRKKLTLQAIHYMTQRDIRKFDRIRELLTMHEELKKAKKDFENPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSM3</accession>
    <name>A0A914YSM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20417.t1">
        <property type="protein sequence ID" value="PSU_v2.g20417.t1"/>
        <property type="gene ID" value="PSU_v2.g20417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20417.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18680" checksum="BAC6BEE05B5885BA" modified="2023-02-22" version="1">MAGRAGRRGIDERGMVIILSKGGEAYDLSDLLPMLKGEAISLQSKFRITYNMLLNIIRDEQLNIEDMLQRSYVERVSLRALSSKNEKIIYLKEKLDILPILSCSDCTDVEQEASILHYYTTLMAYIQKRGILFDKLITRSNVDEQIFPEYSMYACMCSIIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTB6</accession>
    <name>A0A914YTB6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YTB6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3247.t1">
        <property type="protein sequence ID" value="PSU_v2.g3247.t1"/>
        <property type="gene ID" value="PSU_v2.g3247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3247.t1"/>
        </source>
    </evidence>
    <sequence length="457" mass="50589" checksum="7B033661279A7531" modified="2023-02-22" version="1">MTVIKDAIKKAIASRHFNGLITETFEFAINQEKHALEKNLNPFPVVVKDCFAVQDIRMTCASKMLENFIPNYTATVIQRLIDHGGCVIGKANLDAFGMGSTSSQSYFGPVKGSISNIDALEKDWRIAGGSSGGSAVAVHQGFADLAIGSDTGGSTRNPAAFHGIFGFKPSYGTLSRHGLVPLANSFDVPAIFSQSATECAKYYTMMAGTDIMDSTSTDPLPYTSLELPQIRIGIPKEYNHPTLSADSLAAWKEATELFQSAGCKVIDVELKHTDYSIVCYHILAETDIASNMARFDGVSFGHRSKNDFKSFNDLLAYSRSESLNDTIRRRIFVGNYYNVRENRGKYFQQAAKVRRLIKQDFDQAFNEVDVLLTPVTSHSAPYYSEVNAAKFKHRQRQDDYYTQPANMAGLPAISVPFSTCSEGLPIGVQLICNYLEDYRLLDIANILYKLNKSELNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTI7</accession>
    <name>A0A914YTI7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTI7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3469.t1">
        <property type="protein sequence ID" value="PSU_v2.g3469.t1"/>
        <property type="gene ID" value="PSU_v2.g3469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000001">
        <property type="entry name" value="Protein GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010748">
        <property type="entry name" value="PRK14150.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3469.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14187" checksum="DF503DCBCCD73BC1" modified="2023-02-22" version="1">MENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTL6</accession>
    <name>A0A914YTL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20786.t1">
        <property type="protein sequence ID" value="PSU_v2.g20786.t1"/>
        <property type="gene ID" value="PSU_v2.g20786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20786.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11558" checksum="64E20CE7DC808F79" modified="2023-02-22" version="1">MPEEIYHNYEKLTKSLPGIGDILKGHQFLNGNGERQDFKKAAEFYAKAANMGYPEGMYNLGQLYYEGNGVKRDYKEAMKWFLKAANLKPSDVTVSHSTFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTU4</accession>
    <name>A0A914YTU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTU4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3571.t1">
        <property type="protein sequence ID" value="PSU_v2.g3571.t1"/>
        <property type="gene ID" value="PSU_v2.g3571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="203"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3571.t1"/>
        </source>
    </evidence>
    <sequence length="715" mass="81980" checksum="DAD9946B1A22730B" modified="2023-02-22" version="1">MGFEQQWFSHPRKFGPGSRSCRVCSNHHGLIRKYGLNMMVVKRVKPGKPKRVAKKTVVKKSHKVDTDDSKKRVSFAKKLTHSKIIEEDVNVSQNFDVTPSKGILKTRKRIAEQPDHELAPAVKTKSPTFDKENRTPVERSEEASKKKQPIQKFPKAIGKKKLVVKKSIKEKLLAMNPKERKAFLRELKAKSKPNFELSSELKVYWEKLRSSKTPESVKEESIEKLCSMIKGSAAKLIYAHDTSRIFECLLALKRDDIRDALFNELQPEIIKMSKSKYARYFVLRMLKYGTAEQRNRVFNAFEGHYPAVYRVSWSSSVLETAYSDYASCTKRNAIVCEFYGKEYAFLKKTGAPVPTIQTIKAFDKQRQTEVAASLYEHLETAVGKEHINHSLTHRLLSDFFAIATKDQRAEMIDLLKDRVPQFCHTREGSRAAQYCVWYGNVKERKVIVKSFKDLVVNTVKDEFAHRVLMSIFDTVDDTTLVNKYITKEIGNFIGDVVLEKFGQWILHYIIHPRDYRFFHKATVELLSQGDGNEHTKKPASERYREIFDALKKPLLTYMAANMEELLFNKMTSTLVLNMLEPEIENEPFKRVIDDEDKIACFKAIAEVVGKEFIPFNLEGDPHIIEGGCARFTFMNLLKRDDLQGNIKLSDYLAELPSDHLGSFIAINNGCFVLRNMVKSGSQKAKNAVTKAANMKALKKSPHIGAKHLMEELDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVB2</accession>
    <name>A0A914YVB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3917.t1">
        <property type="protein sequence ID" value="PSU_v2.g3917.t1"/>
        <property type="gene ID" value="PSU_v2.g3917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF25">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3917.t1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43614" checksum="46AD05C22B5AB65E" modified="2023-02-22" version="1">MWPYIKFLNPNVSEIANGVFQGTSALGNAIASIFAGYLVNRLSNTKPPLIIAKALMIGATFVYLAVEWNTKAALYLLIAYQLIMGTASGFGNVYRTHIAMATQESERSRGYGLGMLSNSLGTILGPLVQLLFALIPYPGLKLLFGMHFNLFTAAVYLALITSIVGILALIFFFNGKLHVLSKEERVKQQLEIATVLPDVPIPITAAAAEEVKVEEVEEIKYDRIAVCILIFTKITQEINTLILLSIAMPYAMTVFEWNSHELILYQSLFMAPMGICSLIFSFCYIRFKFDKKISVRIALLIGLGLFMFFFIATFPWPFISQTIPYAHEKNATAYFKQSEAAAALAMYNHTGELVGCNIAYKWCETTPRIHIAVFSTSVILVLGIGIPFSSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWE5</accession>
    <name>A0A914YWE5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoenolpyruvate--protein phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.3.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YWE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4876.t1">
        <property type="protein sequence ID" value="PSU_v2.g4876.t1"/>
        <property type="gene ID" value="PSU_v2.g4876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050499">
        <property type="entry name" value="PEP-utilizing_PTS_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46244:SF4">
        <property type="entry name" value="MULTIPHOSPHORYL TRANSFER PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46244">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE-PROTEIN PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01736">
        <property type="entry name" value="PHPHTRNFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="15">
        <location>
            <begin position="398"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4876.t1"/>
        </source>
    </evidence>
    <sequence length="544" mass="60412" checksum="D76A7C042EEBA8F1" modified="2023-02-22" version="1">MILEKTGRTSHTLILARASAIPVLSGLPLDAIARYAGQPAVLDAQCGVLAINPNDAVSGYYQVAQTLADKRQKQQAQAAAQLAYSRDNKRIDIAANIGTALEAPGAFANGAEGVGLFRTEMLYMDRDSAPDEQEQFEAYQQVLLAAGDKPIIFRTMDIGGDKSIPYLNIPQEENPFLGYRAVRIYPEFAGLFRTQLRAILRAASFGNAQLMIPMVHSLDQILWVKGEIQKAIVELKRDGLRHAETITLGIMVEVPSVCYIIDHFCDEVDFFSIGSNDMTQYLYAVDRNNPRVSPLYNPITPSFLRMLQQIVTTAHQRGKWVGICGELGGESRYLPLLLGLGLDELSMSSPRIPAVKSQLRQLDSEACRELARQACECRSAQEIEALLTAFTPEEDVRPLLALENIFVDQDFSNKEQAIQFLCGNLGVNGRTEHPFELEEDVWQREEIVTTGVGFGVAIPHTKSQWIRHSSISIARLAKPIDWQSEMGEVELVIMLTLGANEGMNHVKVFSQLARKLVNKNFRQSLFAAQDAQSILTLLETELTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWZ9</accession>
    <name>A0A914YWZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2606.t1">
        <property type="protein sequence ID" value="PSU_v2.g2606.t1"/>
        <property type="gene ID" value="PSU_v2.g2606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054489" evidence="1">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="246"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2606.t1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60876" checksum="3D200F97832B6160" modified="2023-02-22" version="1">MLLPFFLSLFFYISFFINAIGENADFMGGGADDDLAEYGTLSKSSHVSSKEGYGFLLNFEGAIFKLDKKRQLKSGVVNFYWKCSTKDCKRRVTTNAVSDFNHKICAKSDTEHCHNVNGIVTAAKLARSEIANRARATNDRINEIVSNIQSALPAPVLIALKEKETLLRGARKVRNQANGHPADPASLGSLEIPDEYKFITMRDQNGGRDRESDFIVYDSGAADGENRFICFSCDTLLELLENSANWFIDATFKVTPKFTYQLLVIHAQWRNTHETIPCAYFLLNRKNQETYERAFEALKTLVNNSPETVMVDFEKALHNAIGQAYPTADISGCFFHFCQSIRRKLDELGLKVVLRENFQLATSMTMFRALAFLPAQYVVRAFVLLKNHLAANFEELPEYPQIQAFTEYFEETYVGRIARNNRAGPPLFERDLWNMHDRTIEGSPRTNNNVEGAHNKLHSFFNCDKPGFFKFADLLRKFLKTVETDVFNLRAAKPPKKLSDAWRLLEQRKQTALEMFDANDIIGFLQTMASILIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYM3</accession>
    <name>A0A914YYM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytidyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3144.t1">
        <property type="protein sequence ID" value="PSU_v2.g3144.t1"/>
        <property type="gene ID" value="PSU_v2.g3144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000089">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="3">
        <location>
            <begin position="104"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3144.t1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51861" checksum="95A0C0585FEE40FA" modified="2023-02-22" version="1">MVEVGLLVLSRRAIPFIAEKLASAAQQVRTRLYVRIDPQRSPNELRQLIPTIYLYASQKCSHLDVRVLLKEKQGADYGTFLHELNEKDDGIPNDEPTPFKHVCLGGTFDRLHNGHKVLLSTAALLSDKITCGVTGGEMNRKKTLYELIEPLDRRIDVVEEFLKDITDGVTVDVQEIQDPFGPAIVIKDLDCIIVSQETVKGGQAVNQKRKERGLSELDIQKIELVEGSDEILKEVKLSSSSQRYQLLGSLLKPPNEFLSTTTSTVPYVIGLTGGIAAGKSSISKFLAENGCEIADCDKIVHELYDGNPKFTKAISEEFGVDTISNGTVDRKKLGSIVFQNREKREKLNKIVWPAVSDVIQERIKKTTSDVFVIDAALLVEAGWQSTVRQLWTVFIPRAEAVKRIVERDGISEKDADLRIDSQLSNEARIAASHVVFCSLWEEKETQRQVLKALNHLRQNYIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ78</accession>
    <name>A0A914YZ78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5405.t1">
        <property type="protein sequence ID" value="PSU_v2.g5405.t1"/>
        <property type="gene ID" value="PSU_v2.g5405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5405.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20643" checksum="4DC05A06F887E9B1" modified="2023-02-22" version="1">MDICNNSPKEASFDFFVYVSKKKLKKIEIKTEKIEEFQNEFPQANVIAAVTVTSKAESAAPSPIPPVVIQTVDLPDFGNNVAIADDLTSNFDESMSMISDDDSALFDAAAAQIDDIFPEVAEEATEVDEVQITKRQQKLLEQNVNALSATLSNFNVIVSTHNGKSNITGYSLGINVAEELNVPFKKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZD3</accession>
    <name>A0A914YZD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZD3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5456.t1">
        <property type="protein sequence ID" value="PSU_v2.g5456.t1"/>
        <property type="gene ID" value="PSU_v2.g5456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036850843" evidence="1">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5456.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26480" checksum="7F83DC3256F3DE6A" modified="2023-02-22" version="1">MTTTFDMLKLFLILFGCLSFGAAADYGQITTWTNDAVNEHCRKDSTEWCKNNFCSAPMVTASCPTKRGRDTAETNKFKQLCRHGEDNNRHIDGKYITDADMNACLTCGIRVCDLPNFPAVNFECYKPICVTANSHTIQTYQMDVCPSNHQKNVAKCCMWGGAWCSCVIRPTLDLSFNAYNALGDVHSGSWTIGKTCSSSSGCDDKQPPGGYTCEQQKEWGKCTESWMEGYCRKTCGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZE3</accession>
    <name>A0A914YZE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Autochaperone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5317.t1">
        <property type="protein sequence ID" value="PSU_v2.g5317.t1"/>
        <property type="gene ID" value="PSU_v2.g5317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01344">
        <property type="entry name" value="PL2_Passenger_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043990">
        <property type="entry name" value="AC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051551">
        <property type="entry name" value="Autotransporter_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006315">
        <property type="entry name" value="OM_autotransptr_brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01414">
        <property type="entry name" value="autotrans_barl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35037">
        <property type="entry name" value="C-TERMINAL REGION OF AIDA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35037:SF3">
        <property type="entry name" value="C-TERMINAL REGION OF AIDA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18883">
        <property type="entry name" value="AC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autochaperone" evidence="1">
        <location>
            <begin position="316"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5317.t1"/>
        </source>
    </evidence>
    <sequence length="408" mass="42882" checksum="EA1AD05EAF17057D" modified="2023-02-22" version="1">MTDEESPIEIKDNNPISNGEYLTTEDESHAVKVDDGVTGYINNASVMTSGDGSYGISVDSQNKVLYISDSDIKTSGSVSDKENRGITASAVSSRVGHIQRDFCQVNDSEKMVNNTRLETTDKTNIVTSGENAVGVLACSSPGESRTCVDAVDDEVSDSNSYEVISRADLKMNGGSITTNGINSYGAYANGKKAYINLDYVALETVADGSYAVAIRQGNIDIKNSSITTTGTKAPIAKIYNGGELFFSNVTAVSKQDKGISIDASNIDSQAKIALLSVELSSALDSIDVNKTTTDVSILNRSIITPGNNVLVNNTGDSIINLSYDDGQTFTQGKTLTVKGNYVGNNGQLNIRTVLGDDKSATDRLIVEGNTSGSTTVYVKNAGGSGAATLNGIELITVNGDESPADAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZR4</accession>
    <name>A0A914YZR4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit TMEM147</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Transmembrane protein 147</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM147 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3523.t1">
        <property type="protein sequence ID" value="PSU_v2.g3523.t1"/>
        <property type="gene ID" value="PSU_v2.g3523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019164">
        <property type="entry name" value="TMEM147"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869:SF0">
        <property type="entry name" value="BOS COMPLEX SUBUNIT TMEM147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869">
        <property type="entry name" value="SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09767">
        <property type="entry name" value="DUF2053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3523.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20513" checksum="691E12A0EE07DBBD" modified="2023-02-22" version="1">MMVLATFFPDLETEEFSVILEFFKSLADGFDILGLYFAITYAFVGRGEVRFFAAGYGFAIGHAIGTFLVPFLTVARATAFHPKYIQYAMEANLDLVYYLAFAAIIWVQSRHDITSKNRTIVFFSVALCGLKSFFYGMLQHSAGLSSWSLMSAKFGLTAAYAALAFHAYSLYRSQSNPVHVKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZS2</accession>
    <name>A0A914YZS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent MTase TRM10-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5430.t1">
        <property type="protein sequence ID" value="PSU_v2.g5430.t1"/>
        <property type="gene ID" value="PSU_v2.g5430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5430.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12848" checksum="FE7294BF14ECA7D5" modified="2023-02-22" version="1">MDKENIIQSINVVKKYRFTPIYLPIRKYIKWESGGFYMPLPNILRTLKIVAETGGDWETAINQNVAYRHTIPIQQQREKIKHIYDEKQQLRREKTELIKMIENTVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZV9</accession>
    <name>A0A914YZV9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZV9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6029.t1">
        <property type="protein sequence ID" value="PSU_v2.g6029.t1"/>
        <property type="gene ID" value="PSU_v2.g6029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF44">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6029.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19278" checksum="A6DF78D72493B4EF" modified="2023-02-22" version="1">MGDIAGALQSAELIPSVLPAAPKEKLNLIFDGINVEPGKEIPIRNLKNAPRVTLKVDPESTFSLIMIDPDNLSRKNPSVAEWLHWLVVNIPASNILEGINGGQHQQPYGSPAPQPRTGEHRYLLVLFEHQGRRLQVPKYNTRAKFSLKQFMEKHKLDAPLAANYFISKNEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0M1</accession>
    <name>A0A914Z0M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0M1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5902.t1">
        <property type="protein sequence ID" value="PSU_v2.g5902.t1"/>
        <property type="gene ID" value="PSU_v2.g5902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="7">
        <location>
            <begin position="185"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5902.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34523" checksum="6EF4596567EECC06" modified="2023-02-22" version="1">MEELYCNISEEIFMIGSIYTSEMKNKLYGDKDMENDISVSRYSSKGPFISTCARGIDFVAPGAAITDLPKWNSKNNAICSGTSFAAPNAAGSIACLLSALKANKIQYSPAMIKMALANTAFLPKGANKLEFGNGIIQINDAFEFIKKSMNKLPQKLIFPFLLKQPKQKGIIYVQTDKNNAKPLSKDYTFHIDSTAFNRNNTKWILKCISNENKNFVSHSKIVKTNNNSFNVKIDANELKEGSINYAEIQGFDSLNPTIGPFFHLPITVICPANPNFYTDNIATINAGPATHFFSKNFQQNLLKNVLSKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1M3</accession>
    <name>A0A914Z1M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1M3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6607.t1">
        <property type="protein sequence ID" value="PSU_v2.g6607.t1"/>
        <property type="gene ID" value="PSU_v2.g6607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6607.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="9011" checksum="E89A8508D44A7A98" modified="2023-02-22" version="1">MLLFKEVISPFYVFQIYSVLVWYNDNYQYYASIIVLMSVMSIAMDIFQTRRQEKKLRSMLLMLFYCLNVLLLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2B8</accession>
    <name>A0A914Z2B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2B8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6040.t1">
        <property type="protein sequence ID" value="PSU_v2.g6040.t1"/>
        <property type="gene ID" value="PSU_v2.g6040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6040.t1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52527" checksum="9D47D26D10E73B86" modified="2023-02-22" version="1">MILIKNRNDKKDDIDKKTNELEIKGEDEEDVFGVDYIVEHRKASEINFVEWNQAWNGSMDELAFLVKWTGFDSTENTWEPLENVLTCVKFEQYLNKFLVPTIGRTLRKGRGRRENVSFEFIEPKVNQCYYLKDLQVSNVNCVGHDDSDVHDHDFVPTPPPKKAKYSAIRSPKVVAKPKKTKQDVESNAASYALHNLLNGENFVFDEGNAVSENIVADETADFFGGAPDVDDLLTEPHVFEADVILGNFDTPRGRPTKNVPQPTTRVTRSRTFAASSTAPENDVVVNTNSLGSYSNDQQQTYPVPLQNDFDYSFNNNIIPPSTSSKIDPNPRTSFSNDPMLMGNYEDLYSDNRYVPPISDGFKNVEENEKQNFDGNFLASENLEEDLSIHFNFNGSSSNNAGFNSIMNPYYQQQNITNETELFDLETTYDNPFNLFGFENASALLEPSIGYIEDFMDVVQEDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2J7</accession>
    <name>A0A914Z2J7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2J7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4477.t1">
        <property type="protein sequence ID" value="PSU_v2.g4477.t1"/>
        <property type="gene ID" value="PSU_v2.g4477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF338">
        <property type="entry name" value="CYTOCHROME P450 CYP36A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4477.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30915" checksum="CDD83AC22BA37CE1" modified="2023-02-22" version="1">MTCVGNIIHQLAFGATTDIKDNLIYDFRNKMIEASKIFNHPLTFLMELWKPIKYLKFLGGKSYQKMIDYNNELIDYVKMHIKEHRATIDFEGEPRDYIDAFLNEQQKQQQQSSTNLNNNILMKGEWSDLQLIGTLLDLFGAGMETTSTTTYMFIFYILHNPMIQKKIHEEIDNIIGRDKIITMSDQPKLPYFNACLQEVQRLTTVLPMNLFHRTFEDMQIDGYTIPKGTTIIPQFESVHKDENEFKAIVKFWRSVISRHKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2P3</accession>
    <name>A0A914Z2P3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2P3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6979.t1">
        <property type="protein sequence ID" value="PSU_v2.g6979.t1"/>
        <property type="gene ID" value="PSU_v2.g6979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000045">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045760">
        <property type="entry name" value="YtpR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6979.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="24669" checksum="01D8FBE3A9CC3800" modified="2023-02-22" version="1">MLFSESWLRRFVNPKLGTEELGHQLTMAGLEVEEIQAAAPAFEHVVVGFISEIAPHPDADRLRVCQVDDGSGKLLQIVCGAPNAAQGIKIPVARVGAELPGGMKIGPVKMRGVESAGMLCSGRELGLSQDHDGLLVLDADAPVGQSLRELLDLDDQIIELKLTPNRADCLSVLGVAREVAALTGEPLTLPDFTPVPVTIEDRVSVTVKDADLCGRFAGRVIRGVNARAKTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z377</accession>
    <name>A0A914Z377_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Decaprenyl-diphosphate synthase subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z377"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7146.t1">
        <property type="protein sequence ID" value="PSU_v2.g7146.t1"/>
        <property type="gene ID" value="PSU_v2.g7146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7146.t1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50628" checksum="63AF20FC4D767D75" modified="2023-02-22" version="1">MDILKRCSGSTFCSYAKRFEKGFCSVLYVYGALPQSLSGITLGRSLCTAIDDKVNHHHQKKALQRNVEQSKIVHHPQRNISYSLPSVAELDAAGKETSPTIPEYIVKRLKNLQIDIITSILEHSQISSQQISSKTTVTNFSKNLQEMAKYYFDQGGKLFRPTITLLMSDACSQITKPNYTGDDLIDLNQYRIAMVSEMIHTASLVHDDVIDESGTRRGAPTVNARWGNRQAVLVGDFILARATKVLCSIGEPPVISTMAEIVEDLVQGELMQLTLPPELEPVQRFQHYMTKTFYKTASLFANSCKSVAMLAGCDEKVQKDAFEYGRHLGLAFQLVDDMLDYVATSEVLGKPAASDLKLGLATCPVLYAAHDYPELNQLINRRFKNDGDVEKALKIVIGSRGLEKTKELAKEHCYAAASLYPHYIVQCEYCRFLTFIFKIISFHGYCTIYESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4C3</accession>
    <name>A0A914Z4C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4C3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6848.t1">
        <property type="protein sequence ID" value="PSU_v2.g6848.t1"/>
        <property type="gene ID" value="PSU_v2.g6848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037687172" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6848.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13108" checksum="EE6F8E48A67DC289" modified="2023-02-22" version="1">MVFFNFIIIYLNLLLFCNACFPTPTVEPGPTIMCDPTTCPAMMPPVMNGPIMQDSSTCEITRMAKCMGSMRIEYNMNPSETYGPGAVEWTCDQTTMKYTYQDMSSVTQQINTVNCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-09-13" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4Y7</accession>
    <name>A0A914Z4Y7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g5320.t1">
        <property type="protein sequence ID" value="PSU_v2.g5320.t1"/>
        <property type="gene ID" value="PSU_v2.g5320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037434663" description="C6 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5320.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22052" checksum="2D6ED6C15A80B9F1" modified="2023-02-22" version="1">MSALISLLLLLNSVKFGQSCIAATTPRVTTTTQLCCPPLSTRNPPRQIAPPGTPGAALDECAVLRRIQRGECPLTAEIVCSGARGMSVDQVILQFLSGNTVVASQTGVTRTSVTIYCTSAGYRVRNAAGTLVAFTAVSCTQRTLAGPDFTDYYAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z571</accession>
    <name>A0A914Z571_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z571"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7040.t1">
        <property type="protein sequence ID" value="PSU_v2.g7040.t1"/>
        <property type="gene ID" value="PSU_v2.g7040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="750"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="549"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="630"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="654"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7040.t1"/>
        </source>
    </evidence>
    <sequence length="815" mass="91172" checksum="970E33B913D6E2B5" modified="2023-02-22" version="1">MDPITAPPVRILQTSELKVCNHSDVVHHIEYDYYSRRLALVSSDKIVSIYTKLPHNRGWTKTGQFRVNGGATLRVRWANPVYGQIIATASFDGNIYIFQEHSKFNSTYSYSEMSLDNKGQLIISEWNQKTHIKSSPPTTITDLRFAPHYFGLLLGACNSKGEVHVYEAPSSLNLDTWIPVMKLQVFEYRCRAISFSTDRFNTVLMAACTDDDRSRADRQIAIFPYARTCDIGVEIPEITYICPYAGLNVPLPPTDLEFSPTGAYAFQRLAIAVGPCVVIYHINAILKTPNDEASDSPVSSLSESSANTVVRAPTISISAPKSEEEETAEHEDDTHNESDRPSRELKRKHSQSKPKPEKIETVKEKVPKKTVQFMIDSSASRAGAKSPVPRKPLEISSEPAKIKPSLKQPKPIQETDDEKTPIADLSYNFSEICQLSDATPDGEASVSDEISVPSPIPIPTKQSGGDDSPKIEERGREEEKAEDADSENSETPAPETKIESILNESKSNNSPTKKRQENPPIEIIQFRRVNRDIDQRTFYDDIDEDEVSASTIRQTVPPIIRPKPSIFGREDSTTPMMGRQDSRSYNRRRIERHSPDSQKAEAAAAATTILRKDSDIIKPPEQVAELIKRSVKAKGKKRRHHMGESDEHHKSLEDLASSLSSDSGNNHSISRTAKKQVENEKIEKSGKKSPSSPTTQKITTQYHDVDGRLSSASIIIRPSADTGETVPDKYQHEEDDLTKIKLISMRQAILRAGRAQVKKLSFNHTGTLITTVYSDGIVRVWKRINPTFWHCSSVIEPPIVKGREDLEVLPEGAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z620</accession>
    <name>A0A914Z620_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z620"/>
    <dbReference type="WBParaSite" id="PSU_v2.g569.t1">
        <property type="protein sequence ID" value="PSU_v2.g569.t1"/>
        <property type="gene ID" value="PSU_v2.g569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g569.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17834" checksum="B8B3E113287938C3" modified="2023-02-22" version="1">METLSSTATFSEQDADCSDINEWYMKTAFARDDNGNMIVNKEDPLAPVKPTTDNMILETFESAPHGLTWKEFTDIYMEVHGAFFPENEREAVEARLESVPGIEVSEIDGCKVFDLIDVLTSSYSFECSSREPLPSYYSYDNSSIGVHTALEFEAALEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6F3</accession>
    <name>A0A914Z6F3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6F3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5822.t1">
        <property type="protein sequence ID" value="PSU_v2.g5822.t1"/>
        <property type="gene ID" value="PSU_v2.g5822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030055">
        <property type="term" value="C:cell-substrate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037843">
        <property type="entry name" value="Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160:SF13">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5822.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35991" checksum="395FB6C108AFF918" modified="2023-02-22" version="1">MFGCYCQIQPKKLGFNNFKRAYFVFRDLFLSYYNAAQDQSGPPLGHFNLKGCEVTQDIKISEQKFHIKILIPSSDGMNELILKCDSEPQYAKWLAACKLASRGKTMADSSYNSEVESLKRTLLLQSGKQQNGGDSKGRAPIVQFPSDFNPSEFVSNHYVKRAGESRLKSRISDAHSSIRNLSNSEAKLQYIRTWESLKGHGLHYFIVKFFDERGSRKPELIAVSNRGLFLVNSDNGDCIKPWPFTKMKKWHVNWEIRHIRMAFDLEEIDFKPLSADCKVVHEFIGGYIFVSMRSKDQKQALDEEGFMRLTGGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7K8</accession>
    <name>A0A914Z7K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7K8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g831.t1">
        <property type="protein sequence ID" value="PSU_v2.g831.t1"/>
        <property type="gene ID" value="PSU_v2.g831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g831.t1"/>
        </source>
    </evidence>
    <sequence length="489" mass="54937" checksum="109B3DE3D2EA8E33" modified="2023-02-22" version="1">MGGNNDDDTHSIASTNFSTDTTAYNNGFASELNSRNPSIQSLLSQDIQSFDWADLMADEEERAASQLAKLPETDSNGNQEDDLSSERTGASTPRKLSVDHQSTLDRNAASTQRPQLSSTNDEKISTVEEEGEIQDLTKKIEQLETKENENYIQPSTSNVEEPTTPIAMEKQPFAEVNNRQETEFKYSNEKIIIKPSYIDDADGDTESTSLRHLIQKSINCLNQLTEKLQAVFRQSILPEITEAEMISYLKDSSDCFNDSINKIISLKTNYPSSNEDFKKCALEAMKVRLFAEKAVQLLAVRKHNYVLTFVTDITMKALYVVSALIVYDLEQAKKYQLIEAFEAIWQKLISRVKMQITSFGKTIVMQLITLIRSSIATVTEQLEFEKHIGELVKAIINTNFSDFTQGILISSATVVTDVPPNLLTFAGNTYRWHGDLARYQSMILGSSDYNPSLKFYFLSFVLDPQNGTALNQMGAVASYKVILTFLQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8C1</accession>
    <name>A0A914Z8C1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8C1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8924.t1">
        <property type="protein sequence ID" value="PSU_v2.g8924.t1"/>
        <property type="gene ID" value="PSU_v2.g8924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8924.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12922" checksum="984A67671492B47C" modified="2023-02-22" version="1">MADRIFAELENLSNEMAENKHDYLQKIQQTPPPWTVMQKASFQPDIQELQGNLDDWKENIAKLEAKANVMRNDDDAKAEMFTRIDMVKNTKRALIKDLKKIILQGNSYINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8T2</accession>
    <name>A0A914Z8T2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8T2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8741.t1">
        <property type="protein sequence ID" value="PSU_v2.g8741.t1"/>
        <property type="gene ID" value="PSU_v2.g8741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8741.t1"/>
        </source>
    </evidence>
    <sequence length="574" mass="64866" checksum="268D14E332C45FF3" modified="2023-02-22" version="1">MTRPKAAALLENTPGSSTQSESSRPSQSVNPPPKDDIEIDPWDPIDKRKCREVHYPEFQYATNANGEEKQRLFVFEPNSRVHMREYAKYVRDRWYCLGCRSQPYRKSNQGRIERNQFYAPLEHHCKPVSYAEALVKQQKIKMKISENRDLIGSGNKYVYGNAAFTGSNQKSNTDIQKPSLNSSVSMTAMTIGFREVNENGYFYGYNADGTPNMRLIVYEQNDKGLLREYGYTTSKWYCLGCSRITKTRNFAGFENGVLKCPVAHLCQPYTKKEVDDRQQLFERRKGAQKRGPKGPTKSPAAKRAAVFSTGRQSDDDHVEILSSSNISSYDEIPGYSPSDISAALSSRKSSHDNTSDPDEAILDNSNITQKIEIPEQQSAETPSVISLPSFNLDGFPSPITSTFSFNNPSKLWLKTACETLQIPYNHEAYQLWATIDIDEIRSISKPENVKKVTAGEDSGFCAISLLLTGREDAKIKIAVNKWFYKNFNKLGKCLGVDFTHFVHNDTLVFETFFATDLVPVHCEALSHILGCRLGVYDNEKLIKYGNWESDDGKVTLLLERKSNGYNVVTSLFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8X0</accession>
    <name>A0A914Z8X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8X0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9119.t1">
        <property type="protein sequence ID" value="PSU_v2.g9119.t1"/>
        <property type="gene ID" value="PSU_v2.g9119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9119.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29795" checksum="BC149EA4D65ECDFB" modified="2023-02-22" version="1">MAATSSAQFLQEVPRRYVEQIQTTVETMRRRGISIYDGIFRLANRSSALIEKTREHIEPMAYDVKDFVVAAVNNNKPLNEKNRDLRNNLLEMYLGISVLCVGLSSGIICGATFMGYILSSFINPFIELISLFGIPSYAYMYFRKNAGIDETERRVWLYGLSYFIGCIIGHGFGARLMSVVPAILFISPLIFALLIDFELGPRDLFADRQRLMIISGGISSVAAYILAYLVSGFAFAPIFAIIAMNGLLWVHFQVTFSFFNTLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z940</accession>
    <name>A0A914Z940_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z940"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6764.t1">
        <property type="protein sequence ID" value="PSU_v2.g6764.t1"/>
        <property type="gene ID" value="PSU_v2.g6764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000083">
        <property type="entry name" value="7SK snRNA methylphosphate capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="115"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6764.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40937" checksum="6D4DB6D7EF20D6E4" modified="2023-02-22" version="1">MNESPNLVPEINSNAKKVDDDSINIQFDPSHSIKQDDKIELNKSKRKINDSINDDNSDSPPSKKKQEVNSIKCEEDKPTTSLPTKKQKQKEMSEKFRYGNFHRYYGNRLKGLQRDPRLDVFNKVWFQRRNVLDIGCNAGYLTLSIAKEFEPAWILGIDIDSHLVGVARANIRHYCEEKEMIGKFPASLALREEEGGPTVKKFPNNVWFRRQNYVCLMDEEIEQAQEEYDIILALSITKWVHLNWGDDGIKRFFLKAFKNLRPGGRLIVEPQGFNTYWKRAKTVDELRETYNKIEFKPEQFKDYLLNEIGFVSFEELGMPQANAKGFERPLQVFRKEVYKGENRKKVKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z998</accession>
    <name>A0A914Z998_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z998"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8901.t1">
        <property type="protein sequence ID" value="PSU_v2.g8901.t1"/>
        <property type="gene ID" value="PSU_v2.g8901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011945">
        <property type="entry name" value="HAD-SF_ppase_IA/epoxid_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02247">
        <property type="entry name" value="HAD-1A3-hyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8901.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26851" checksum="30727F751701B01D" modified="2023-02-22" version="1">MPQIKAVIFDLSGVISLKQSTTTYWKKLENERNLPEGSIKKTLLSKEFAAISYDLFTGNRSAEEIEENEFIRLFNRQHNTASEPLPVIRNWFGEGTSAIDLDENVVAAIDALRDAGIKVALLTNNYYLNKQKTVRRLPSDRSRFDVIVESCVEGVMKPHENIYHLTIDRLALRPSECIFVDSQKVHCDTARHVGLKTIYARADEREWMLCELEDMLNEDALSDESYESDSTEQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9G9</accession>
    <name>A0A914Z9G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9G9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9317.t1">
        <property type="protein sequence ID" value="PSU_v2.g9317.t1"/>
        <property type="gene ID" value="PSU_v2.g9317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9317.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12537" checksum="8AA2E6288DD55BF7" modified="2023-02-22" version="1">MKPFFTKLQESKTLPSISPSITTTTTKNGSQKTDSIPERAELNKKLLIEPHYASLLRHKCLGEHNSAKAREMRRRYPRNMGRPLQFREIKYLSLTVAQMFKEVNKMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9S0</accession>
    <name>A0A914Z9S0_9BILA</name>
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        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g6998"/>
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    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
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            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
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            <begin position="237"/>
            <end position="264"/>
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        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
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            <begin position="354"/>
            <end position="368"/>
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    </feature>
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        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6998.t1"/>
        </source>
    </evidence>
    <sequence length="430" mass="47247" checksum="E52B2AC6C07E9D44" modified="2023-02-22" version="1">MEKRNEDNEKSGRKNPRNVRAGKKGAAIKNGENEKDKDQGEDNQQRRRTQNNRNVQVGKKSAGARNNQNVDEEEESDDQKQNRNTQNNGRKNPQKVQAGKKGAAKNGQNNNNDDEKEEEVDDESAGDNGEGKNPNRVAGGRKAAAKRLENEKRNSRGGRNNNKNASKADKKGSIAKNDNKSKGTRRGNKAGSNNQQRASGSTKSDNKNNQDPKIKGTIEEEHKYWVMVAEDVDEVNAESHDYDDYYKKDPTRVEAGKKGWETRQRKIRKDKRSNNGQSSKSKNANDNNNQDSKTDIKDNQKSSQSSGNKKQSGGSQSSNANKRRANNGMESGASMNKNPRLSAAGRKGAGVQGKNVTQENHSNQSMDSNATAPLIGLVADANGNPLPITIQINVVPEADVSIQVEDDGNVKQNSRGRNGPRKAPIRNRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA64</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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        <property type="gene ID" value="PSU_v2.g8815"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8815.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8917" checksum="45BE18357E166B50" modified="2023-02-22" version="1">MMKLVYVGLIVLFVVVMLSTSDALHCNLECPFGSECLNFKCVPSPGRFKRGKNQWDQIPCQTDKDCPGSFCVGGFCYTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAR0</accession>
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        <name type="scientific">Panagrolaimus superbus</name>
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            </authorList>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
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            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
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            <begin position="169"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="267"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9002.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39143" checksum="0924D07293BC46C4" modified="2023-02-22" version="1">MSKITIFLIFVVFYKVINAANFATQCFLPTFHRGISNASPIAELWNVGPFDCLMYCIVNAGKTGDGCASVVYHRRFSTCQLYGHDGTFDGAKIVFATGHDYYNRTSYEGICQDRHTPSRGYAQRQKHPKVHGVKLQNGIALNSSSQKVSTPFNYPKAYYLYANEPKGECSRRQKLGYFVLKDFELTRTAPVAKVNGIDRFACLNYCAQNINAHGDFSRCVLISYDARTEECQLHDESAKEAALFTRIEPKEYTLVAEKFCFDKSLRCPAETHLRVIAGQEINDRPLHTFTHFETLNECTNACFEHPYCKAVVMQANTCTLYPTILSSNLELLRPASGRNTVVVDCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAU8</accession>
    <name>A0A914ZAU8_9BILA</name>
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        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <begin position="108"/>
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        </location>
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        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
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        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g889.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22001" checksum="2D09CBCA59E0E900" modified="2023-02-22" version="1">MMSILGATPEDMEEVLKSLGYRHEALEAPAVAAKLAELDAFAEADAAKQAGEAVAEPAAEAAAEVVEQPATEEAPVAEAAAPEATAEAVAETSDAAAAEEPVKMVLLWRPGRHDNRPREQNRNRPRPQGNRRAPAKDGAPAGDAKDNAGDNQSREQSRDGRSKRFEKAARVDFRNGEQKSGRNEHQGKPRHAKRDHDRSGFTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB25</accession>
    <name>A0A914ZB25_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RBR-type E3 ubiquitin transferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g9118"/>
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    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22771:SF4">
        <property type="entry name" value="CULLIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22771">
        <property type="entry name" value="CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9118.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="30018" checksum="6632B545ADCB7CE1" modified="2023-02-22" version="1">MLKFWLKKCSDDSETSNWLNANTKDCPQCHVTIEKDGGCNHMTCRSVTCKFEFCWMCLGPWKPHGSGWYSCNRYEDKEAKEARSAQELSRAALQRYLHYYNRFVNHQNSLKFENKLQDQIKIKMQQMQAHNFTWVETQFLANAVAVLNKCRRTLMYTYAFAYYLKSNNASNVFEDNQRDLETATEQLSEKLERELDIDTDDLVKIKQEVQDRYRYVDQRREVLLKHCFEGLERGEWVFNLPQQQQQQQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBD9</accession>
    <name>A0A914ZBD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBD9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7568.t1">
        <property type="protein sequence ID" value="PSU_v2.g7568.t1"/>
        <property type="gene ID" value="PSU_v2.g7568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="44"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7568.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37313" checksum="F8A84CD4D7038D60" modified="2023-02-22" version="1">MIVVEFVNQRVDVKLFHGQIIMVERVTFGTLDGGSGGGGYSLRKTYEGNNFFDGFYFWNYNDPTHGCVKYVDKGTAQSLGLIGVENGKVRISSDSKNTYNGNEGRPSVRIHSNDKYNDGLFIFDLEHMPVGPGTWPAYWFCGDNWPNNGEIDVLEGVDGNTANNQALHTNENCYMPLDSSIFKGRWAKGPGGKISNDCYVNAAGQSTNQGCSITSEDGYFGVPFNNAGGGVFAFEWNRDNSLKIWIFKRNQLPADINSGNPNPSNWGKPEAYFTIGNSCSANHFNNHEIIINLTFCGDWAGNVYNGGMGACENKVRSDPGAFKDAYWLINHLKYYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBY6</accession>
    <name>A0A914ZBY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9435.t1">
        <property type="protein sequence ID" value="PSU_v2.g9435.t1"/>
        <property type="gene ID" value="PSU_v2.g9435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9435.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27900" checksum="CE838BF4EB66890B" modified="2023-02-22" version="1">MLENERDDLKIEFDQLQNERDDLKSERDDLKSERDQLQNERDDLKSERDDLKSERDGLKSERDAFKFERDDLKIEFDQLQNGRNKRELDELLQRHKSPIRDAVEPSNVVEPSNPSNVVEAEVVSSSNVVDSVTSSSERVSSQCTEEESDARTSSHVGTPVTNGEISVEEPLSIQDHNSSVPVFPMNPPLFGNHATEKTGAQSSDEDNADDDVELDPNDTADALVLRSLPRLNEYLQLGQHQISCPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCM7</accession>
    <name>A0A914ZCM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9686.t1">
        <property type="protein sequence ID" value="PSU_v2.g9686.t1"/>
        <property type="gene ID" value="PSU_v2.g9686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22084:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22084">
        <property type="entry name" value="GEX INTERACTING PROTEIN PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9686.t1"/>
        </source>
    </evidence>
    <sequence length="701" mass="80810" checksum="F2BC95E9C51B82CF" modified="2023-02-22" version="1">MHARRPQSRRVPTSIGGTAIAYDAGSRNDPNMKYVRLVSANEQASTSYAMTTNFQPPQELFPNAQIITGTSPDGAIVEYVIDQRDFDPSGIPPTMYVEVMPNIHAPEQQEEEPQLNEEEVLAIENGYLNAIDAPVKKSRYSRMSEADRERYNARRRQRRLEKKKKKMEEDELAKAVEESLVDNSEPVENIVGQQEAKVPIVQKTEQIITTNISPMPPQFSPIPDMKTSVGEEKTSRTETARNRYHAMTEEERRLYNQKRASAFRKKRKEEEILLSTTPECSSPGRITRAQEIVIRNARRAEKARQRYQRMTVEERREYNQRRTIAKKARRLAKSQALREAAALGQHQRQPLQRPQQHPRQQSRRPQQQPPLQNPSQSSNLYVQQRAFDNGINTDIVNEEALLMLERDVVRRTQVAQMALRKQRKEKQNRPYNTIDDTIEQVATYGAALPLNEPKDHTVVENVQDYIEPSTLPLVIVDQHGNPANLPEGSIIEVRQEHPNGPQTIIIHTAPPPPPNHRFIQPPTQPSMIQFVTTSVAQNALPLSNYVQEEQALSELKPSSNDSPELPKSEILRVRRAARARERYHQMGVEERKQFNSRRAVALRKARVRDEELCRLGEDARKSGNELNNDTMKAINDAQQRRAKRAESARLKYQRMTVEERRIYNANRDANRRAKKRDSEPFESNEKNETLKSEEPLEYSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDV1</accession>
    <name>A0A914ZDV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9854.t1">
        <property type="protein sequence ID" value="PSU_v2.g9854.t1"/>
        <property type="gene ID" value="PSU_v2.g9854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9854.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14248" checksum="520AD08539016BB5" modified="2023-02-22" version="1">MARIASFTDPLLNPILVAVRTPTIRRRLRYYIYVATNALAIIFCPWKTFRQKPHRRTASSSQRKRSTTARSPRRCSSTTGTYESASGRPESVDSEITLKLFCTGQRIRSSILRRSGHSNHHNSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHG0</accession>
    <name>A0A914ZHG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZHG0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g973.t1">
        <property type="protein sequence ID" value="PSU_v2.g973.t1"/>
        <property type="gene ID" value="PSU_v2.g973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050366">
        <property type="entry name" value="BP-dependent_transpt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43386:SF1">
        <property type="entry name" value="D,D-DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DDPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43386">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g973.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7398" checksum="019D1433E94FF264" modified="2023-02-22" version="1">MWESSLSFLGVGVQPPEASWGLLVAKGKEYLFAAPLVAIMPGVAILITVLAFNFIGDGVRDALDPYMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZI22</accession>
    <name>A0A914ZI22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZI22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9955.t1">
        <property type="protein sequence ID" value="PSU_v2.g9955.t1"/>
        <property type="gene ID" value="PSU_v2.g9955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF53">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9955.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36425" checksum="80EF27938173A931" modified="2023-02-22" version="1">MNPSQRNLYADTDTDIPLTYSSGVEDDPSTDPSMNGNNGKYVDLSQQYLTFIPNEMFNGPGARFDIKFITELNISNNRFQTLPTIIFQMSSLELLDISNNSLSMISPEIGNLTKLKALSARNNLITVLPKTIIKISQLQEINLAGNEFIEFPSSLLQLQNLKSLYLGANKLITIPENIDLLSKLEILYLGGNRLTSVPDALGNLISLSSLALCDNQLDTLPPAFGNLHNLQTLSLHNNQIRFLPTEIITLQNLSNLSLRNNPLVSKFVNSVEFAVPTLKELAARSIRINYTETEYNNQLPNCMNTYLESANFCVNPKCKGIIFYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSD0</accession>
    <name>A0A914XSD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSD0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10181.t1">
        <property type="protein sequence ID" value="PSU_v2.g10181.t1"/>
        <property type="gene ID" value="PSU_v2.g10181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10181.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7805" checksum="57DF36ABE3B4F3C4" modified="2023-02-22" version="1">MSGIVSNHMIEYPFALEWKISEDRLKSLKDSKENEYIQSDIFTAINASGVKYYLQIYPNGHNDEFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT03</accession>
    <name>A0A914XT03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT03"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11096.t1">
        <property type="protein sequence ID" value="PSU_v2.g11096.t1"/>
        <property type="gene ID" value="PSU_v2.g11096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11096.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34055" checksum="C2D5DB72284B97B7" modified="2023-02-22" version="1">MIFAATVEHAKEIVGLLPAEDAALITGDTPGAERDVLIENFKAQRFRYLVNVAVLTTGFDAPHVDLIAILRPTESVSLYQQIVGRGLRLAPGKTDCLILDYAGNPHDLYAPEVGTPKGKSDNVPVQVFCPACGFANTFWGKTTADGTLIEHFGRRCQGWFEDDDGHREQCDFRFRFKNCPQCNAENDIAARRCRECDTVLVDPDDMLKAALRLKDALVLRCSGMSLQHGHDEKGEWLKITYYDEDGADVSERFRLQTPAQRTAFEQLFIRPHTRTPGIPLRWITAADILAQSKPYCDTRILSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTM5</accession>
    <name>A0A914XTM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11310.t1">
        <property type="protein sequence ID" value="PSU_v2.g11310.t1"/>
        <property type="gene ID" value="PSU_v2.g11310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11310.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42352" checksum="67526C3A6FA43ED4" modified="2023-02-22" version="1">MKQKHVHQVLTKSRERFNEFFLTSTSSTPLSIITCIDRCKKGELQKHFVHEKSGEDIQKSENSEHNPKFSVHFTTPKDSESNNLITSSFDETTFTPQSIVITEDNLKAGNKSVKMIPQPLEIENVSAKISASSASASSTSDGSKSVNVNEIVREIQNFTVVKKDGGTVFSGRRPKLVTISPEEFEKIVGSDTLLKTVNTTRKIQVQGEDIEKIIEAVKQQIETNQKNLVTKDNDKNDKKNSEAKEFSTTTPKSSFATTTTEPIVVNGKVLSPSAVRELVEFERTSTTTTTTPRPIILTTEEGFMNTFVISGVGDIFKEALAERNNQGQGHLSPKDSTDATAASESCYRTISQQLLYRAAFEKLGGRVSMNECRCACARFEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTU6</accession>
    <name>A0A914XTU6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914XTU6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10395.t1">
        <property type="protein sequence ID" value="PSU_v2.g10395.t1"/>
        <property type="gene ID" value="PSU_v2.g10395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10395.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30261" checksum="1CE6949243D06550" modified="2023-02-22" version="1">MEDRSQHLIEWIEFQLLMNADKIVIYVYSITSETRKALEFYSETKKVEIIDLSLPGYSPNTPFIRHNYIARNRQQKRRSELIPYNDCFNRFSQSHDYVLIVDSDEFVVPLKHDNWPDMLESLKNPTFSSSSSSLAIRNVFKLETFDHTSKSPLKMLKHNFRSKMVQDKGISEKSFINTKTIATVFNHFALHRLFGNVTRTQHIDPNLAIKLHYKSRCPEELGLHCKEIVENPIRDESLDRFALKLEENVAKVLLSIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUB7</accession>
    <name>A0A914XUB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1084.t1">
        <property type="protein sequence ID" value="PSU_v2.g1084.t1"/>
        <property type="gene ID" value="PSU_v2.g1084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1084.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8133" checksum="30CD441679CBD9FA" modified="2023-02-22" version="1">MFRIPLQDDELLIPLMKKGHIPRGPPRFGKRGGATAPSNHLRLRQFSLYGPMMHLLPRNNEMQEFNPYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVZ7</accession>
    <name>A0A914XVZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10701.t1">
        <property type="protein sequence ID" value="PSU_v2.g10701.t1"/>
        <property type="gene ID" value="PSU_v2.g10701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10701.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27950" checksum="31521664BDCEEE23" modified="2023-02-22" version="1">MIEKTLPKSLKLLYNFFKTQNIEKGHFDVEFHFGGDEILYAHKTILWPISTVFEERLFGSWKDSSSSASNKATKIPIENYSYENFKEFLTYFYIEKCKISNDNVISIVDLSEYYHLETLKEKCDKYLSKMEVEKFEIILWLEFSKLYSLKFASMHFLDLLRSNISDLIYSECFLKAKKDTVKAIISSRWLNISEEELFDAVLKWAKENIEKGDDDNFEESLKKMLKEILPQILKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWD0</accession>
    <name>A0A914XWD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWD0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12243.t1">
        <property type="protein sequence ID" value="PSU_v2.g12243.t1"/>
        <property type="gene ID" value="PSU_v2.g12243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12243.t1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39509" checksum="CAEF93DDB91508DB" modified="2023-02-22" version="1">MKNQAVSLNSRFLHFIGWDQFCIDKLAKAEKVLYANVQEKIKFRHIRIGLGNSSIYTVSLTEKTFPSKIPFVILHGIGGSSGFWATNFDELAKYRPVYAIDLLGFGRSSRVSLSSNPIKAELEWIQSIEEWRKVMKIDKMILIGHSLGGYLAAAYALKYSENIQHLILIEPWGIDEKPEKLQPGIMPWWRNLFKNVVYPCIILSLTRICGPFAKSFLREQFPDLPRRHQISESDSDNIYEYFYQINAQKPTGETTVKTLSEFGYAKNPIIQRIVELNSNLPITFIYGDLSACKSSTGFKIKEMRSKSYVDVNVVKGVAHHPHIDKKEEFNILIKNINHFIEENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWF0</accession>
    <name>A0A914XWF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWF0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10859.t1">
        <property type="protein sequence ID" value="PSU_v2.g10859.t1"/>
        <property type="gene ID" value="PSU_v2.g10859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10859.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="18048" checksum="639987A78EC62978" modified="2023-02-22" version="1">MLADALLEEVEEAEENVQKNVEEFLEYYKKIWTGYTYRRREKEPRYAIDIWNVYEATINKEPRTNNQSEIWHGQLKEAVRINHPPFYVISKELQKQHSNGIVLRNQLITGVIFKKKKVQADKDERILNVVRNFNVENVLDFLRNVNIAATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWY4</accession>
    <name>A0A914XWY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11481.t1">
        <property type="protein sequence ID" value="PSU_v2.g11481.t1"/>
        <property type="gene ID" value="PSU_v2.g11481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11481.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41436" checksum="1E7276904DDE130C" modified="2023-02-22" version="1">MQIVERLRGSVRFVREGVYQNCPNTMSNNDRRINTGNDISSNQNESIEEVNTPTLTTEPLELPDSPENERSIICCCFTSETALRVLFLSYWIWSLLAFVFSVDTIFPALYLFPICFMLIAFIGSSIGVYQLLLPFMFMVAWDMLYATTCAIFLVSFHKNDRYAMFNKLIYDYWPQKAKEFDEMSRDFFEVCLIIFFFKIFYSMAAFIITGQEVVRFKLQQYFEVRRREIIRQRVLLDLREESRLQSFLIEAAQTNESQNPYAQLFSQRPPPPSYQTFSHPVLRTPQLGTPPPTYSMLERDGRLEPVPIQWSPDSQNNNQSGQINASETSFNCKRSEGSTAMSPSSFLHSPPFNSSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX85</accession>
    <name>A0A914XX85_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF112 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX85"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11819.t1">
        <property type="protein sequence ID" value="PSU_v2.g11819.t1"/>
        <property type="gene ID" value="PSU_v2.g11819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35342">
        <property type="entry name" value="TRICARBOXYLIC TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35342:SF5">
        <property type="entry name" value="TRICARBOXYLIC TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF112" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11819.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12221" checksum="B1BDB6610DC7CB59" modified="2023-02-22" version="1">MIPGAGADIAAFVAYNETRRFSKTPENFGKGEIKAVASCEAGANGCTGGALLPMLTLGIPGDAVTAIMLGALTLQGMQPGPLMFTDHGDNGLYTVCRHDLLLLHATSSWTALFESHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXC3</accession>
    <name>A0A914XXC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11180.t1">
        <property type="protein sequence ID" value="PSU_v2.g11180.t1"/>
        <property type="gene ID" value="PSU_v2.g11180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11180.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7257" checksum="9401981A96945F3A" modified="2023-02-22" version="1">MGVGLGVAMMMQQAGALVGATPQVDIDRIEAEVRKAKAEGRTVTLINGCLYFDYQLVAQIPPHVDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXQ6</accession>
    <name>A0A914XXQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12730.t1">
        <property type="protein sequence ID" value="PSU_v2.g12730.t1"/>
        <property type="gene ID" value="PSU_v2.g12730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12730.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18673" checksum="7E6FFDC7B44CC814" modified="2023-02-22" version="1">MDENGGAAPEPVLEVPPPKEIQILETAEEIDNRRSEVLTHYQQFKHFAQEKRNHLEEARQYQYFKRDADELEIWILEKLQTASEESYRDPTNLQSKIQKHEAFVTEVQAHANTITKLDKTGNDMIQQNHFEKETIRVSFFFSILTFIYFFAAEYLFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXX0</accession>
    <name>A0A914XXX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXX0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11803.t1">
        <property type="protein sequence ID" value="PSU_v2.g11803.t1"/>
        <property type="gene ID" value="PSU_v2.g11803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11766">
        <property type="entry name" value="SH3_Nck_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11767">
        <property type="entry name" value="SH3_Nck_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000110">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF14">
        <property type="entry name" value="DREADLOCKS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="96"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="175"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11803.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31339" checksum="8B4EA24D41A279B1" modified="2023-02-22" version="1">MMTESSYATAKYNYDPQRPDELQLQRGDNVLVVERSSDGWWKGEFNGQTGWFPSNYVEAAPDPSPVASIPQQHPYAPDYTKDISSAFKNGTATHAPILEVVTTLYDFDAQNAEELSFRKGEKLEIIEHPLHDPEWWKARNSHGLIGLVPTNYIKVQANGENASSTLAGPYATEEWYFGAISRNQGEQLLNQRGIEGDFLVRDSESNVGDYSISLKGNIRNMHFWVRANHQVPSFQIGNRTFNSMNQLINHYKSSPIFNDEKTRETLYLIRPLSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYC4</accession>
    <name>A0A914XYC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYC4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11958.t1">
        <property type="protein sequence ID" value="PSU_v2.g11958.t1"/>
        <property type="gene ID" value="PSU_v2.g11958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11958.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="10780" checksum="8334076BFB7DCD7F" modified="2023-02-22" version="1">MGYLGHGRGHCRGPMHGLGHVPVASLAQWHAHSGLHGLAVDAGWTDAGPSGLVAGPTAGQFLERRANRWLSLPVSGRCTPGLYPVVPRDCRFTLCGRVFAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYE4</accession>
    <name>A0A914XYE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12974.t1">
        <property type="protein sequence ID" value="PSU_v2.g12974.t1"/>
        <property type="gene ID" value="PSU_v2.g12974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12974.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37704" checksum="8825D92DEB23DC56" modified="2023-02-22" version="1">MEVDHIRDDAELIQEPKKKPKRKRQRTAQIRQDLRKALEKAILAPKCKILPFFIRKDGVYSANLYLILKHLIQPQIQSFFKLNSFALKSLNNRSRIFMISGATDAKPENLKIEFSTKLRARVMDTIAYVDNLPLLCTPERLSRRAAIFGRVVDVYLPPPRKVPQKHAMLRGSLKVNHAGYGFIQFTTSQAVKRFCKRYIANSHLRRHGRKTRRKRIRAISKSQQSISQIQAEQEPEDPVYEQTSVYQQELLSGLESGLESDYEFTKKFKSVAFNLSNVSSSKEENNEISLTEIKMPTKKKKTRRKRTTIGEAVSLKVLFRGIQVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1G7</accession>
    <name>A0A914Y1G7_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1G7"/>
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        <property type="protein sequence ID" value="PSU_v2.g12633.t1"/>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12633.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8655" checksum="6ADADD505ACFB7EA" modified="2023-02-22" version="1">MTTSTQEQQQSSDLIKVGFSDLKQGEGSFWNYESKLFSISAIKDYVNIWKIELYAFVIKLINFLSSAFLMDMVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y401</accession>
    <name>A0A914Y401_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y401"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13505.t1">
        <property type="protein sequence ID" value="PSU_v2.g13505.t1"/>
        <property type="gene ID" value="PSU_v2.g13505"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13505.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33001" checksum="5B2CDC47ADF8984C" modified="2023-02-22" version="1">MQILHGNGKGFERELSLPNLVKGFTTADQQQWLDLIFEASGVEETIKQAEDALIAQEFQVREKRSYEQRMRGPNGEPLYLTKEKAIETLGNPEAKRIEVSETLIKTYSKNQMKEMNETGYAILSKEQMEIVYGHGSPHADSKKLKMFGNMSAEEIHRRIEKDIKAMAEKRLVRTKRTILLSPFVNSAVLFAPEVASQPIILSPILFTSVIGSPAVLGPIILGPWLFLPLILSPRILSPAILNPFLFVPIILSPLALHPAILCPGLFNPIVLSPLALTPFILSPQVCKFMFNLLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4M6</accession>
    <name>A0A914Y4M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4M6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14188.t1">
        <property type="protein sequence ID" value="PSU_v2.g14188.t1"/>
        <property type="gene ID" value="PSU_v2.g14188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14188.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20735" checksum="95D12D616E53F224" modified="2023-02-22" version="1">MMGPTDPMQYVPTWQLFIIMILIFGAIYGCGRILEYLLRQFLRCMKYLLLAFIDLYYGDDFEEASNNSNSVEDSNNKRRKREAGARRSKNPETSNNNNTSSKSVLLNTSNGTIERTTVPVETTILKVDIDNENDNVTIAEAMRHSPTDDEGNSSVSPAIRHRNNVVKHSELPESSSPVVTVVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5C9</accession>
    <name>A0A914Y5C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5C9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13980.t1">
        <property type="protein sequence ID" value="PSU_v2.g13980.t1"/>
        <property type="gene ID" value="PSU_v2.g13980"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13980.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23056" checksum="9C8DEB5C1B161FF7" modified="2023-02-22" version="1">MYFIFLEQTSEGARELMTAIIEESTDNFIVRDNEKIVAMHSLKKGFIKEKPKQKQRLEDYGFLVGSGTFKHKRNNIIMTLLDASESNMFKNMEPPCKYFYGMLGAVHPKYHGKKVAEAVVIGLIKYCIDEGAKYYCGDNTNDKIANLFCKLPGFEIVDKFYYSDFKIHGTSVINQLVDGSKHTCLCFCDLEKHKNAYLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5S7</accession>
    <name>A0A914Y5S7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5S7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13028.t1">
        <property type="protein sequence ID" value="PSU_v2.g13028.t1"/>
        <property type="gene ID" value="PSU_v2.g13028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13028.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20406" checksum="3989396A99336CAD" modified="2023-02-22" version="1">MNQMPPRPQQHPLRMTQQFFYPEAQNNIPPELCFAGCYFLYAENPNINELHILIRTIRYHGGEIDVYNVRNLSEKATHVICEYATHVPQILEQKNKRVCTISWINDVIEKKRMEPPFKVCHLPSLAIRNPSVSEKIISITGFTEEEASSLKLMIQLIGAKFSPYLSKHTNILITKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y644</accession>
    <name>A0A914Y644_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y644"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13131.t1">
        <property type="protein sequence ID" value="PSU_v2.g13131.t1"/>
        <property type="gene ID" value="PSU_v2.g13131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13131.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8103" checksum="D1D2CF841D7C4224" modified="2023-02-22" version="1">MSFVLIPEGEDEMAEAEAEGLIPIEMIQNDEIQFQPQQIRLSENDIDELELRERLAQLGEQLTERSIRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6G4</accession>
    <name>A0A914Y6G4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable ATP-dependent RNA helicase DDX52</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y6G4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15785.t1">
        <property type="protein sequence ID" value="PSU_v2.g15785.t1"/>
        <property type="gene ID" value="PSU_v2.g15785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="149"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="349"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15785.t1"/>
        </source>
    </evidence>
    <sequence length="571" mass="65099" checksum="85614C018122E99F" modified="2023-02-22" version="1">MSTKELDFSKILFTGVKRKKLNLNQDSSDGRELRIRVLPETHELPVKKPKKQNIEEANNNEENVVQIFSSSTITTQAEPPSEKVQRDFQAEAEKEKVANIRKLNQIFTWGDEIPDPFINFSDLKLSPEFLQNLSEFQIKDPSPIQMMAIPVMFQKRDVLASAPTGSGKTLAFILPIIKELVDKQEKKLSTIILEPTRVLARQVYVQFVKYCQNLPIKYAFYTENKFPSDAQVVITTPNRLISAVENDKTLIKKLKNLNWIVVDESDKLFDGHEGSTNFREKLGRIFKWCDGAITRKAFFSATFSHEVEHWCKEHLVNVAMICIGARNASNSLVTQQLIYAGSESGKIAAIRDVLKKGFDPPALIFVQNKDRAGQLYSQLRTDFPKLPIELVSSEITDKEKDKILDQVRAKKVFVLICTELIGRGIDLPSVNLVINFDLPTSIVNYIHRVGRTGRAGKEGRSITYFTEADLKYIRPISTVIQQAGFDVPPYTLALERPTKKQKKELQSNEIERKTFGSVKKWEKVKKFKRMNDEIMEVVKVKGQMLADDDAGGDVVGKLRRPKLKGKKKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7N0</accession>
    <name>A0A914Y7N0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y7N0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16208.t1">
        <property type="protein sequence ID" value="PSU_v2.g16208.t1"/>
        <property type="gene ID" value="PSU_v2.g16208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="73"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16208.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39507" checksum="6579558DFA1ECD95" modified="2023-02-22" version="1">MIDKICDKLYISDAASVISERGKQKIQELGISNILTTSGMAIPESARIPNIHYKFIFMMDMLSQDFLGNNLLDDALKYIDKVLTSGGSILVHCEVGVSRSIAIVAAYLMRKHEWNPSKAILFIQNSRPIACPNQSFIRQLAIFRQLGYKADTETLSKSSHYRNFCADTGNLPHHTRGESSDDDHIAERIKKIDLEHTSQKAIAHKRYRCRKCRTDLFYDTHILRHTIGTIDDDEIDHSEELQTPELCSYDYLIAPMKWMNIEEYQGKIFCPKCNEKLGQYIWGGRDCMGDEGKPCGAHVTPWIHIQKSKVDESHMSVLAARLAAIGTHMPPTTTPPTIMHPSESEQAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7P6</accession>
    <name>A0A914Y7P6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g16221.t1">
        <property type="protein sequence ID" value="PSU_v2.g16221.t1"/>
        <property type="gene ID" value="PSU_v2.g16221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16221.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40115" checksum="AF6D59F9DE33540C" modified="2023-02-22" version="1">MLDYLFLQLLHKNHQILKITKVIKPKPGFNITTGALTFGDLSQAVDDFVNEKKKQEVVRKSSIDITENVPPINLSSDNVSVVKEKHNNDSGDDTFITENATVSTFMIQVNKTVNVEIEETFLGNGGDQRKGTDQNLTVNPIIQINESGAEIAEVVEESVVIDNCEQKDDSNNSSKTSIVQVDESAFESPNNVDEMDDDEKEVSQNQLTDADTGVMTQEDETVISQPVAEPSSEDSEESEEEISVVADCDKDTKNKTMPDDQSSVEDDEDNESTKASIEKDNDIAAAAAAPQDDEPKTVEEEEESEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKKKKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y877</accession>
    <name>A0A914Y877_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine kinase NLK</fullName>
            <ecNumber evidence="5">2.7.11.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Loss of intestine protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T-cell division asymmetry. Component of the beta-catenin-lit-1 complex which promotes the phosphorylation, down-regulation and subcellular relocation of pop-1. Regulates plp-1 nuclear localization in embryos. Plays a role in male tail tip morphogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y877"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1380.t1">
        <property type="protein sequence ID" value="PSU_v2.g1380.t1"/>
        <property type="gene ID" value="PSU_v2.g1380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000162">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1380.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35270" checksum="3F5AC4DC6BE2EE25" modified="2023-02-22" version="1">MQSDLHKIIVSPQTLTPDHIKVFVYQILRGLKYLHSANILHRDIKPGNLLVNSNCILKICDFGLARLWDPADQQNMTHEVVTQYYRAPELLMGARRYTGAIDVWSVGCIFAELLARRILFQAAGPVEQLNQIINLLGTPSPEEMRDACEGAVNHILRIPKKVPQLNHLYSLSPQTTPEAVTLLVEMLRFDPNRRMTVEQALSHRYLDEGKMRFHSCMCSCCHNGARRERVFCSDFDPVHQSPLPPTWEKELSRLSMFDLRDKLYKYVTDRRPMDGIPLCINTNSASYPEFANSSVAQPSELPPSPNAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y951</accession>
    <name>A0A914Y951_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dipeptidyl-peptidase III</fullName>
            <ecNumber evidence="5">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y951"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15801.t1">
        <property type="protein sequence ID" value="PSU_v2.g15801.t1"/>
        <property type="gene ID" value="PSU_v2.g15801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15801.t1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49793" checksum="0901BC61498BC18C" modified="2023-02-22" version="1">MIQKYIEHFKSGSLDAHKDASRFWVKDVGPVVESYIGFIENYRDPAGARAEFEGFVSCVNKETSKKFSTLVSRAEELLQRLPWGADYEKDKFLKPDFTALDIIYFGGSGIPAGINIPNYDDIRQNEGFKNVSLGNVISAVPKQKIEFLSADDEAMYKKYFKESFEVQVGLHELLGHGSGKLFQNEGEKLNFDKNKVKHLITGEPIKTWYEKGETWSSKFGQLGNAYEECRAEAVGYFLCCYPDILQIFGYEGQVADDIKYTNWLNEIRAGLVCLEFYQADAKKWGQAHSFARYVLLRIALAAGQGFVSIEECVDENGKADLKFNLDRNKIDSVGKPAVGDFLKQLQVYKSTGDFAGGSKLFNEWGAVGPRELRWREIVVARRKPRRNFVQSNTVLTNGKVELKTYPATNAGVIQSVVERYGEDAVNDALNVWEKDVKIFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9H0</accession>
    <name>A0A914Y9H0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9H0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15929.t1">
        <property type="protein sequence ID" value="PSU_v2.g15929.t1"/>
        <property type="gene ID" value="PSU_v2.g15929"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15929.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15876" checksum="88367686E9080B86" modified="2023-02-22" version="1">MPWHDGHSVVYGEAARDVSRHFIQRWNAAKRQKIRNNDLYPYLIPKSYDNIQIPNALITPDLHKVELQLLRSVSRWSALTDKTEDSIHRAYVSLIKNSKHYIYIENQFFVSMINNADVSNLICKTICERIIQAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAN4</accession>
    <name>A0A914YAN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAN4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14561.t1">
        <property type="protein sequence ID" value="PSU_v2.g14561.t1"/>
        <property type="gene ID" value="PSU_v2.g14561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14561.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17571" checksum="33992F71CEB3E85E" modified="2023-02-22" version="1">MKSFWKNNELDGCDIEVQIENPFEVEIEGKKGDFTVGHYATKDIDMSLSFVFYPTILQTPNQNNLSNSMMNGGLFGTQQRKILSPLHSTGATATPNLPNLTKIISPENTPKTSPSPQSISTTAKSTTPLTPTPAPASKPQKLSTSFTKDARRREKITKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB77</accession>
    <name>A0A914YB77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHK kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB77"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16538.t1">
        <property type="protein sequence ID" value="PSU_v2.g16538.t1"/>
        <property type="gene ID" value="PSU_v2.g16538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16538.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18983" checksum="1F79A6CC91A81A23" modified="2023-02-22" version="1">MMLRMEKVLFLHSLEKILSSDESNSKTWFTEDNRKALAKVHEFECGFYNVLTNVIDIPVPKAYKTIEWILNEQDGCIHIKDLTSKGKTISYFDNVNLTQIKCFIRHLAHWHKNILCSDPGLWRGKFISKAMDAFGTALEGIGQQGKIFMEKSNLKGVFDTSSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB84</accession>
    <name>A0A914YB84_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="8">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="8">HAD</shortName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914YB84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16022.t1">
        <property type="protein sequence ID" value="PSU_v2.g16022.t1"/>
        <property type="gene ID" value="PSU_v2.g16022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Domain A (catalytic)" evidence="8">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Domain B" evidence="8">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16022.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23046" checksum="416C045FB557C6F6" modified="2023-02-22" version="1">MSSCCEVYNSPKWIEENRCDFKPPVCNKCMFSDQLKVFFIGGPNERKDYHLECGEEVFFQVEGGMILKVVEQGKHRDIEIKQGEIFLLPGKIEHSPQRSEGTIGNVIEREREKDELDCLRYFIDGTTDTLFERWFHLNDVVKDLPPIIKEFKESEEAKTGKPGPKAKLQEPAYQTDKSRKLADPIDLNKFINDNLAMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCA2</accession>
    <name>A0A914YCA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MHD domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15103.t1">
        <property type="protein sequence ID" value="PSU_v2.g15103.t1"/>
        <property type="gene ID" value="PSU_v2.g15103"/>
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    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15103.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14975" checksum="81E47FAD3041A6D9" modified="2023-02-22" version="1">MIKAKSQFKRRSTANNVEIIIPVPSDADSPKFKQAIGSAKYTPEDNAFVWQIKSFPGGKEYLMRAHFNLPSVTSEIQEGKRPIRVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCN5</accession>
    <name>A0A914YCN5_9BILA</name>
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        <submittedName>
            <fullName evidence="4">DMAP1-binding domain-containing protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g17057"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
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    </dbReference>
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    <feature type="domain" description="DMAP1-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17057.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10315" checksum="0BC1A01F7C1A4BF5" modified="2023-02-22" version="1">MHDPPEVVDISKLPAEVRDSLAQLELELSEGDITEKGFKKKRDKLLLPFLGKKIEKNGAGDSSPSTNAQRRRQRRLTRNESRYHSGTILTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD38</accession>
    <name>A0A914YD38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD38"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15369.t1">
        <property type="protein sequence ID" value="PSU_v2.g15369.t1"/>
        <property type="gene ID" value="PSU_v2.g15369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15369.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24264" checksum="298C3C2637C83032" modified="2023-02-22" version="1">MERSTEFVIKDTEANDPTAFLAFKEDPNLEKLPALIPRPEFNIEKHTKLCTAVKGSLPESGYQELLALPQVLKNYPPCEEFTVLLERIRHRVIAPESKAAPISADPNNEQLDAFKKSGVIEKVWIKPQFLLSPFGDRSKTSSAVPLQRVAEKRKLHEKSTVAPASTADPVAKEKMDQPKTALKVDHKRSKKTAESPANDAPITSKAKVGRPRKILIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDZ0</accession>
    <name>A0A914YDZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15640.t1">
        <property type="protein sequence ID" value="PSU_v2.g15640.t1"/>
        <property type="gene ID" value="PSU_v2.g15640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15640.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="42173" checksum="B922C400406B1283" modified="2023-02-22" version="1">MKVLYSKIKAAEDDIEKWFELLLEADIDEFVIQNVENRIAINLHDVKLWQTYIDYLKELIQREYDDMESTDNENILFDDKSQVQSDENMDDGNKSRVSESEIHTMQHFCAKFFDTAKHQNFALPRPIMYYILKNSDHIVLQKLFKSCKYFFAEKFTPICYSLVETHKETSYDNEKLSLNYKDIKKRLSQNTFVTTSKEIIPRLSRSEAKYIELWNQNLSFDDLKFLIEHGNVIELFLKNCDIQEEADGNLVELEKIMEFLPNIEKFDLYPVKCNSNTGHALSNLKFNSKINYLCLANINGESFDPNEFRKFCTANQAQSFSLIMAFDIDKSLLFEFVSVMFEYAESFEDTDFKCYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE86</accession>
    <name>A0A914YE86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15719.t1">
        <property type="protein sequence ID" value="PSU_v2.g15719.t1"/>
        <property type="gene ID" value="PSU_v2.g15719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15719.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20948" checksum="E02A48A05E88F908" modified="2023-02-22" version="1">MVSLLLILENQSTSGGSETAVNSGFQLPLSQSFIRNSSTATLDRLCYVLLAELFRRHKKLENIENKRRRPSSSSHGGGIVDEYGSHKKDDVQYKTPKHHGSGNLLSPGISAHWQSSHPGWRDGKYLVEENRWQYRSSNKKGQRLPSENDVEFNTDERWFRNERTPSKSAAPARPVGIFLKGEIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEA1</accession>
    <name>A0A914YEA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEA1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18586.t1">
        <property type="protein sequence ID" value="PSU_v2.g18586.t1"/>
        <property type="gene ID" value="PSU_v2.g18586"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18586.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="17327" checksum="C8B27771AF6E59AF" modified="2023-02-22" version="1">MKNYDNHFNELQKQLQKVQENSTDEFKEYFLQLFQEAEKRWKKSRDDYEHLNRKCAKSLPSTATKLLQHPFNESKDEPYKNYQTCNYQGNDYQKFDGDRFGTLKYLEFDPQENEETTVNANLRGKREAFKSKEIVTKRFKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEG7</accession>
    <name>A0A914YEG7_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEG7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17692.t1">
        <property type="protein sequence ID" value="PSU_v2.g17692.t1"/>
        <property type="gene ID" value="PSU_v2.g17692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038077212" evidence="1">
        <location>
            <begin position="16"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17692.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13116" checksum="B6020DEB441CD53C" modified="2023-02-22" version="1">MALLFLAYTIPLPFGGIDVNKRPDGSDEVSVHNGINVSGYGYGSGLTFNGKNGTGGSVSSHSGVLDGHGGQYGIGSTFGGDKKKGVQLDSDLNLGNETVHVSYFWMFDQWISQQFHHTFDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG44</accession>
    <name>A0A914YG44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ELMO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG44"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18288.t1">
        <property type="protein sequence ID" value="PSU_v2.g18288.t1"/>
        <property type="gene ID" value="PSU_v2.g18288"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF2">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="81"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18288.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28215" checksum="B6CD54106A0EF539" modified="2023-02-22" version="1">MARYYTSSKNGQDVIDITQVRFNSIVPDVPNSRASSYYDDSETNVAPCSFQSVWARLSTENISNEKVKRNVSVPFSESNPLHWEILCSFYKHIMDTGRKPVPRYGSHWENVGFQGEDPASDLRGVGMLGLCQLLFLSSNALSPQLALQLFELSIDKVHHFPLAVVGLNFTQFILEHVKEGRLNRLAVQENSYVSVINGIYRGCFITFYKLWKTRNCTILDFSKIANEIKVQIKQRPKFLLNMAVLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGN6</accession>
    <name>A0A914YGN6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGN6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18618.t1">
        <property type="protein sequence ID" value="PSU_v2.g18618.t1"/>
        <property type="gene ID" value="PSU_v2.g18618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18618.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14933" checksum="363B773B1ABA764B" modified="2023-02-22" version="1">MADNGFLPPLFTYANRKVLEYTCQTAYFVSIVVVQWADLIISKTRRNSIVQQGMSNWTLNFGLVFETVLAAVLCYCPGTDHGLRMYGLKFTWWFCALPFAILIFIYDEARRCCIRTWPGGWVERETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHI4</accession>
    <name>A0A914YHI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18936.t1">
        <property type="protein sequence ID" value="PSU_v2.g18936.t1"/>
        <property type="gene ID" value="PSU_v2.g18936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18936.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="22035" checksum="11584B071AB88FA1" modified="2023-02-22" version="1">MKGKLIIAEEKEKMLKDEFNAYKDQMKVKQGEYQTRFNKIMELAGRNEEKDIEYLGKMNPGPSNGRKRHRSFSSSSSSSRKAKKTKAASPSRRTDDSDTQRVLDIIVNMDNWKAFAKQHGKDQNTPCFLLSTYLWWVAELNGRGKESYNQRFKPSGGRHHNSFLVREEQFFKNNPEIKKAQKITKPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI94</accession>
    <name>A0A914YI94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YI94"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19211.t1">
        <property type="protein sequence ID" value="PSU_v2.g19211.t1"/>
        <property type="gene ID" value="PSU_v2.g19211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF52">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="207"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="486"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="742"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="868"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19211.t1"/>
        </source>
    </evidence>
    <sequence length="1058" mass="120685" checksum="4E5FF5D56D63A353" modified="2023-02-22" version="1">MTIPSSQVQNVTTDGVAPTFQNTKFCEYYNPQEIISKNNTLTLEYTLRGSRSDNNFWVSWTTLGCGGIILRNNSELLVSKSHFTPSYDKEERQCQWTIKAPIGFVAKISIEFAYFMGNIEQKQACDDPSNPKRGNDNDGIEFFAGTDNSSGIPQKILCGIINNQSWTSQTNEVFAFMRLAPENPMNKNDIILKGKVEFVKLQNDASCGGIILLDNDTPTVIHSPNYPKAYPKGIACIWEFHAPNGSLVAFNLSEFNNPYGQRRHYYGTFDGITPENCSASMAYLEGSLAFYEGSYNASEAYIRSNRMMHRVCLQIDKPRFIISRSQKVVVVFHGSPQELSMPSDDKTQKSNGFVLKAWAKCGGTLITKRESQSFIIANGNDENPNSLRFNCTYRFVKDPEDEDEGETLYIRGERIPYADISPRANALDTFTFQCNDEEYENHVDFKQDLALEKDFGDCDGSPVLYTHITEVSGKYLISYGLESQFCGGIIDQFQKHIRFRINKRKPADCEWQFNAPNGFLVNLRVDFVKLPESDLCQESFIEIRQSSANESEPRICSSEDKMRTYVSPQITVRLRYHPNEDRDDEALDEIMGDYTLQMKSKIEIDIFAKSNIIESPSAKVMAQPLMYWLLQAKQNNTKIKITFDRLNVSPYSTTLLSLTPTQCTYDEECSVVFVDGYIEEGMDPRIYYFNSKEIKVEWGKTENFGFFRLKWEEIDEDEYREIIRTNSTENGNNLENLPVFNCGGELFPTYETKILESPKNFFGKYLNDQRCKWTINRKRFSNVMLKITYLDLEEQSTCQYDYVGIGILDLTATELLSSPAGMLTYCKGNTSVAGIPMDLEYHQNVYIYFVTDRSRTGTGFKIEYKLGCRSFDYISDQGVPLRAEITSPNWPLGYRKNESCFWGVILGSTRQLKVTAELDIDGDDHSCGGDSFIIQELPRGFFGAHLGGTKRCGQISFEKVLNGRLYAYFNTDNSEKNRKGFKLILEELVVDCSSTSLWVDEKNPKKFLTSPEFPNLSPNSLNCYWVIHTLPGHRVKFTVDHGTFNLQNSVRDEDGNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIB5</accession>
    <name>A0A914YIB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIB5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20078.t1">
        <property type="protein sequence ID" value="PSU_v2.g20078.t1"/>
        <property type="gene ID" value="PSU_v2.g20078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20078.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7861" checksum="5F7D0D1FA6FCF5F4" modified="2023-02-22" version="1">MMDQTKTKEELSLKSFEEEEELVTARLEPTQQLSDATTQSADNKTSGDTADKSAEATDHTRHANKRSDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIC2</accession>
    <name>A0A914YIC2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2 subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19061.t1">
        <property type="protein sequence ID" value="PSU_v2.g19061.t1"/>
        <property type="gene ID" value="PSU_v2.g19061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="6">
        <location>
            <begin position="77"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19061.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24186" checksum="E40FA6086CA9C3C2" modified="2023-02-22" version="1">MDDEDLVLVLPARKPLKRRPKPVPEDPSIAAEEAAFELGRMNIIDAKKDWPDYPYEELLGLVFGIIRDKNPDLGGDKKKFVIKPPQVARAGSRRTAFTNYAEICKLLKRQPKHVLQFLLAELGTTGSIDGNQCLIVKGHFQQKHFERVLCNYIKEYVTCHTCKSSDTDLIKDTRLYFLQCKTCGSRCSVTAIKTGFTAMVGKRAAARRAAEATAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIH5</accession>
    <name>A0A914YIH5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
            <shortName evidence="2">6PGL</shortName>
            <ecNumber evidence="2">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YIH5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17110.t1">
        <property type="protein sequence ID" value="PSU_v2.g17110.t1"/>
        <property type="gene ID" value="PSU_v2.g17110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17110.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29205" checksum="9E707A178926B229" modified="2023-02-22" version="1">MTLFKYAYNILLQMDTFAKDPVTSGNKNVIVTENKNDMISIIFNEFSKIVQDSQSLVTVGLSGGSMVGIMSDVISRLDQSLKDKLRLFCVDERLVSLDDEDSNTGAYLKVLGNEFKKQFVIVEEINDANKAAKEFEENLKALKPETTESLPQFDVLFLGMGPDGHTCSLFPNHELLNYNGSSWILPIENSPKPPPRRVTVSLPVCNAAKNVIFIVTGESKAEILKEIIADKSESYPAGLVKATKLKWILDKPAAKLLGIEAAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJD8</accession>
    <name>A0A914YJD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19426.t1">
        <property type="protein sequence ID" value="PSU_v2.g19426.t1"/>
        <property type="gene ID" value="PSU_v2.g19426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039952">
        <property type="entry name" value="Aex-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21643:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR AEX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21643">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="33"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19426.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33833" checksum="F85FA7C2FC265B45" modified="2023-02-22" version="1">MSNSSNNGTAPMEHMTAAEVYFYLINGSLGTIFNAVVLVIALRHADTYDKPRQIAVINMTFADLITCLIYMITRPYLNLFPEPLCYPYYVTIFTSQMCSCLNLLWLNLDKLIYIKFPLHYYQMVSRVRVLLLTIASWTIIITLALTIYFFMTVHKMFKRLFFVFSSTIWTCITCLPYRLLYLTYLFCSHARKPGTDFNTILVSLITTFFPVVVIGIVINPWITILTQRMYRECLLVYLHNVFSIFNFCGLKICVFDNPKSRRQSRPSLATQRSSAASRNEFSECKGLKNVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJU2</accession>
    <name>A0A914YJU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clc-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJU2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20610.t1">
        <property type="protein sequence ID" value="PSU_v2.g20610.t1"/>
        <property type="gene ID" value="PSU_v2.g20610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000039">
        <property type="entry name" value="Neuronal SYmmetry"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF51">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20610.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34186" checksum="C9CC737E1C1AD78A" modified="2023-02-22" version="1">MSSSEVGRKATITFSVVLTLIAMVLSIAAILTPSWQVVNLREYNSIHEHGLWLDCTRHSRDSNVLLRRYATITEPLHCVYKFDYDKYSGTFDLEDDNSPVGEVNRHKFYGWHTATLILLGLALLTGFMSVCIAICGCCYGSLALVYTVIMLVTLFLSSIAEGLFFFFSHRADNRFIKGIVGTYEQRVGLAFFLQMAACGFHFISFLVAIVSTYFSFTAHGGVLDNYSVQRSSRTNMTNIGRSMEFDSQMAGFQQNPNKSKIPPYYIKDEYPGFESMPELHHARSYQSDINPPRIRRKSETCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKJ8</accession>
    <name>A0A914YKJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Citrate synthase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20863.t1">
        <property type="protein sequence ID" value="PSU_v2.g20863.t1"/>
        <property type="gene ID" value="PSU_v2.g20863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20863.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18798" checksum="59EB50E02886447D" modified="2023-02-22" version="1">MVYGGMRSMKGMVTETSVLDPEEGIRFRGYSIPECQKQLPKAQGGDEPLPEGIWWLLTTGEIPNDKQVQAISKEWASRADLPDHVAQLLHSFPSNLHPMSQFIAAIAALQGESKFAQAYANGVHKSTYWEYTYEDSMNLLAKLPTVAASIYRNLYRDGSSVSVIDSNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL15</accession>
    <name>A0A914YL15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19572.t1">
        <property type="protein sequence ID" value="PSU_v2.g19572.t1"/>
        <property type="gene ID" value="PSU_v2.g19572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19572.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16234" checksum="8B2ADEDF616B5B76" modified="2023-02-22" version="1">MMIAPTQPIDPYAFIESDEENENKNVIAEAAAAAVVTGTGGGGIKRQKSIGDSGAGSDVSSNTTSPPRNSTLEEEYDEKTPEDSSFLLKRSKKSSENEDADSGFRSRLNSNLSCSPSSHSAISSGSDSPGRKYSTGQDYATEMDVIHKLQHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLA0</accession>
    <name>A0A914YLA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21127.t1">
        <property type="protein sequence ID" value="PSU_v2.g21127.t1"/>
        <property type="gene ID" value="PSU_v2.g21127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21127.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13928" checksum="BE90003B88F5EAD0" modified="2023-02-22" version="1">MILKFQSIFLITGFLTIFIESGYSLNKYIDGYETLNYRPILDRRKRSTTSTESITDDSSIELRFRSHNRVFNLKLYPVDSETVFSDDHQLDINGEYLNTNSIRPEEFLYEGFIKGLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM41</accession>
    <name>A0A914YM41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YM41"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20443.t1">
        <property type="protein sequence ID" value="PSU_v2.g20443.t1"/>
        <property type="gene ID" value="PSU_v2.g20443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF69">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20443.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14789" checksum="BD9C98A3147FC73E" modified="2023-02-22" version="1">MITTLGYGILDPMTINGRVFAVIFGCLGIPITVIMFSNFGRYLQSLEVALTRLCCRRKSRQRIKDEDIQDGESMAGGLTEIDAEVSIDGSEESSIDLLDDMEQISAPLLIGTVILYMVSKLCFSVIMTCIKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNB2</accession>
    <name>A0A914YNB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21095.t1">
        <property type="protein sequence ID" value="PSU_v2.g21095.t1"/>
        <property type="gene ID" value="PSU_v2.g21095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21095.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="6122" checksum="74A1AB65EE519FB5" modified="2023-02-22" version="1">MCLFLVIFGTATAQLGGGLGSGGLGGGSIGGANVEEPHHHKSSLIKDALKGAAIGAAGGAAAHALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNQ6</accession>
    <name>A0A914YNQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase Tc5 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18983.t1">
        <property type="protein sequence ID" value="PSU_v2.g18983.t1"/>
        <property type="gene ID" value="PSU_v2.g18983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007350">
        <property type="entry name" value="Transposase_Tc5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04236">
        <property type="entry name" value="Transp_Tc5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc5 C-terminal" evidence="1">
        <location>
            <begin position="46"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18983.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13391" checksum="58960A7C34098B3E" modified="2023-02-22" version="1">MEDKIRRMFPDFKISTRAHIGCLLNQAIEQLRAPRYSSLIKHAFIKPGYIDQDYDEYQTPDHYCFNFSKIGARCEDNDCGKLAFIRCSWCEKFICFNHFIIKLHSCQIIIDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPR9</accession>
    <name>A0A914YPR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPR9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2188.t1">
        <property type="protein sequence ID" value="PSU_v2.g2188.t1"/>
        <property type="gene ID" value="PSU_v2.g2188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.930">
        <property type="entry name" value="Mammalian shaker kv1.2 potassium channel- beta subunit complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024587">
        <property type="entry name" value="K_chnl_volt-dep_Kv4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11879">
        <property type="entry name" value="DUF3399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent Kv4 C-terminal" evidence="14">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2188.t1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43858" checksum="0EA0C5CE2B19FB3D" modified="2023-02-22" version="1">MSVIDVVAIMPYYVGLGLQDNKDISGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATIMYYAEKKVPDTRFTSIPAAFWYTIVTLTTLGYGDVVPATVMGKIVGGICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQKKARLARIRIVKNASGQALFAKKKAHEQRMHAFEEGKLSVDALKDDDIFEIQHHHLLQCLEKATEREFIENDDYESGLIRGTPPPLTPPITINSAKRIFGSFAKNARGSFNFPTTTTSDPDTEGDNESIEQRQNRTFSCCPITGIRNRNSHGGSGKQRNEEELHTLQSNSHPETYNNSRNPPKVVIENVEIGDTIATRYQVHDEVEALTSIPEAKETDEKKDDVCVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPU0</accession>
    <name>A0A914YPU0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YPU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2104.t1">
        <property type="protein sequence ID" value="PSU_v2.g2104.t1"/>
        <property type="gene ID" value="PSU_v2.g2104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046426">
        <property type="term" value="P:negative regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051985">
        <property type="entry name" value="NR_tyrosine_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="49"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="206"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2104.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47936" checksum="8902E856D63C9560" modified="2023-02-22" version="1">MNRGALISAFAEFDRRNQWIPMYNKLGIETSKQESELGLTAEESFKEINFPKNRYQNVLPYDQNRVLLNNVQEGNTNFLNASPLLVPFANRDYILTQGPLETTAEDFWQMVWEQNSRIIVMLNNIMEKGSIKCYHYFVDNDEKEKTFGNFSIKMEEERGTGVYRIRTIKLTALDKKFLVDDEESTRTISHFHYINWPDFGVPNETRSFLEFLEKTNQAQILLKEEKIESPVIVHCSAGIGRSGAYVIVDCVLNYLQKGNQSDSAAGDTVEVPKSIDELVIFIRRHRMGLIQTPEQLRFCWKAIVDWLKAHPEENGNGDDTLSASSSDVAVTTNNDPSIISPNRKRYSQPDPSIEKRKQKIQEMKDKLRRVEETKNRWWYRLLYDENTKYWVGSSVAVGMAIMAFYVYNSIQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ39</accession>
    <name>A0A914YQ39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21582.t1">
        <property type="protein sequence ID" value="PSU_v2.g21582.t1"/>
        <property type="gene ID" value="PSU_v2.g21582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF27">
        <property type="entry name" value="LRRNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037963462" evidence="4">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21582.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30136" checksum="703EB09951E932DD" modified="2023-02-22" version="1">MRLLSVCICFGILLLLVDVNFAKRRDPNDIDKGEESEDPDEYEDADLPKRKKNTKKSSKGKADEIYDDEEEDDFLYACLKNDKDSVCKCEVDILNCEDSELTETDIYVRDDSFKIKTANFKKNGIKILRYKEILPGYDYEVEVLDFSDNKISKIDDKCLNAFDSLKKLYLSSNRLKTITNRVLTSKIGDTLHQLFLDDNEIIKIHPTTFEELKNLTKLVLDGNNGIQLSKNTFPTALANLEILSLDRCNITKFDDDVFENLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQM0</accession>
    <name>A0A914YQM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQM0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2476.t1">
        <property type="protein sequence ID" value="PSU_v2.g2476.t1"/>
        <property type="gene ID" value="PSU_v2.g2476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="297"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2476.t1"/>
        </source>
    </evidence>
    <sequence length="753" mass="87427" checksum="E9C449E12B332064" modified="2023-02-22" version="1">MGIWLAAKIVTYVSTQMKLEKCEKFIWTDSQISYYWFQKHPKNVFVSNRLKEVLRSNSTCLFIPGILNPADLGTRGISFEELKSSHIWWKGPHFLKQKRENWPKSPEVGNVFNSTITTITAINEATTWQNTESKREIEIDPNLTFSRLKSVVAEQLQLKQANDITATDLKEAEEKLIQQEQKLLIKPKDMKEFKLSKNEDGLFCLNCRFDHAELINSKPVFLPKNSPLTKIIIQDVHEKLHHSGIPHTLSKIREKFWIPSGRNTVKEVLGKCKDCKYWKGKSFALPQMPNLPSTRVNVSKPFQNVGLDYCGPFKVKGDKEKVWICLFTCFTTRLIHLEPVTSMNSEDFLAAFRRFTARRGVPCYILSDNAKQFKTAATALDELWSKSIKDEHTVQYCNENAIVWDYITERAPWKGGLYERMVGLVKNALKQTIGRRFINFVEFWTFLCEVEATINSRPLTYVHSKEAFVIRPIDFISPQIKLTLPTVTVDNEKDDETFLPSDSCGGERLVEHYRKTSIYLEKFWNLWSKEYLNFLRERNDMEHKNRRGAIKRHPIVNESVLVFEPDQPRGLWKTAKVKELIYSNDNEIRSVKIEYSDGFVTRRAINHLYPFEESFENLEPATGHDQNTKTMNSISRISLEEISSSESSESETDKETLRKEMKETRKAESILRKELKVVKKLIKQMVDEYNKVIMTELESGLSENDKDGICNKLLQLNTKILEAVQTRKALLSELAEVRKENQVIRKALNQNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQW9</accession>
    <name>A0A914YQW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribonuclease P</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQW9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3174.t1">
        <property type="protein sequence ID" value="PSU_v2.g3174.t1"/>
        <property type="gene ID" value="PSU_v2.g3174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3174.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23970" checksum="505D3E32BB24DE2B" modified="2023-02-22" version="1">MHPEMKARLKALKEKGRKKCQLAATYRPTFFKCIYSIQFNCVTFVLGITFTKTKRVHHHHIKCLTVKLSAIFNLQSLIIVLLLFICTCAYTRAIVPKIVDRQKIGIAGIFWKCARIGERLSIWVALGKTAFVVQINLLKKLLETKTDCIRLHAVGQSIPRAVALADTLNSCMGNTIKISAGTTTMMALEEFDSHPVERSLSKIIIRVTRIITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS32</accession>
    <name>A0A914YS32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS32"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2463.t1">
        <property type="protein sequence ID" value="PSU_v2.g2463.t1"/>
        <property type="gene ID" value="PSU_v2.g2463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2463.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25084" checksum="4AFB9638D0940238" modified="2023-02-22" version="1">MCNTKIISPTAPIPKVKACDECRDIKTKFCGKFPDAIYCFNSIPNFCKPNSNLAQQETLNISNICYVPQKSFLPLPLFNNNNHSLTIAIPRFFEQESFEQYRFHKLSLFLLFPISRGKNCSSNKIFSSHSVHKNKNCIWTIPVAMPTIDAIEAKNDPFYYDDQTDMSISFSPKIIPVAENSKISVWYSVNSDFIETHQNTPLNFSLPLYSYRRDVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS34</accession>
    <name>A0A914YS34_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytochrome c oxidase subunit 5A, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide Va</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YS34"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20207.t1">
        <property type="protein sequence ID" value="PSU_v2.g20207.t1"/>
        <property type="gene ID" value="PSU_v2.g20207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20207.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20151" checksum="319824C18E6D3EF9" modified="2023-02-22" version="1">MSLLRASSVISRIASQQRSFAVSQSRLSSHDDIMEKWPADKFDKHFIDYLNRPEIDGWEVRKALGELHDFDVIPDPKVVEAALRACRRVNDYALTLRFLEAIKIKCGSAKNREQIFGYIVQQIKPTLTELGISIPEELGLDKPELFIPQSEWWWERKWYKEYGFDKKPGFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS66</accession>
    <name>A0A914YS66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YS66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2495.t1">
        <property type="protein sequence ID" value="PSU_v2.g2495.t1"/>
        <property type="gene ID" value="PSU_v2.g2495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000545">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2495.t1"/>
        </source>
    </evidence>
    <sequence length="426" mass="46569" checksum="10FA8F6501BA15FA" modified="2023-02-22" version="1">MTADTRPVIGIDLGTSCSRLGIFKDGKSQIIANHEGDRSTPSWISFSDDGEVHVELSAHVLRQLKNRAEEYCGCPITDAVITVPAYFSDSQRKATKIAAEIAGLNVLRLINEPNAAAIAYCLEKKKDSKVLVYNFGGGTLDVSILIHSIDDNTFKVQATSGNTHLGGKDIDNLLADYCITEFYLVHKIDVKDDPSAMARIREACEKAKHALSTAQKYRVVLPNLVDKVTCDITVAKMKMDEIDDVVLVGGSTRIPKIRELLKGFFGDKQLSHNIDPDEAVALGATIYAAVLAKVEDCKNVRLVDIISRSLGINTHGGIMSPLIFHGTHIPTRGYEIYTTIADDQEIVPFKIYEGEATLTQDNRLLGEFDFTGIPRAPKKVLEFSLPVEKSTGNKQNFAVKDKNACLTSAEIEKVMHAQNGSADDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSB0</accession>
    <name>A0A914YSB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3057.t1">
        <property type="protein sequence ID" value="PSU_v2.g3057.t1"/>
        <property type="gene ID" value="PSU_v2.g3057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3057.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16576" checksum="D82C81E32BDC35F4" modified="2023-02-22" version="1">MGLSLRPKTVAPDFVKRLISEEVMEGDRLHWTIKVSGDPLPTVTWLRDGQIIPHCNEVQIIDDGKGNHSLIIPKVQLVDSGQFTATAVNPGGEARSSADLVVRQRGEEPGTFFHITKVTQERQVKGEEVSRDQTFSIENPRATPTKQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTH6</accession>
    <name>A0A914YTH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTH6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g346.t1">
        <property type="protein sequence ID" value="PSU_v2.g346.t1"/>
        <property type="gene ID" value="PSU_v2.g346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g346.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16189" checksum="67FECF52BE87A6C7" modified="2023-02-22" version="1">MLPVFRHCAYPDVSQDFITWYKQLTVKNCTIIGNQEMDEKKLINWMDATPRAKTNVKYVDAEGIMTKEGVATLAEYLKMLDLPFTVDLDRILEKKNLLTDVTNDPLKAALGPLNADVDRVLDNRNYPNKFRGNDRKSCSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU86</accession>
    <name>A0A914YU86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3231.t1">
        <property type="protein sequence ID" value="PSU_v2.g3231.t1"/>
        <property type="gene ID" value="PSU_v2.g3231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF16">
        <property type="entry name" value="CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3231.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34112" checksum="3E7BA9C9EB1F6605" modified="2023-02-22" version="1">MHEENLRNVLNSLSHLADHGEIPVHAFGTLLRAAKTEVITEHLHQKWLSDSNFARLAAHIVYHFHTLDNHDVSSLTSGCLAHALRDYKCRDEIRQKSKKMFRNYVHTLAEFYIVYRHIDLCLAQTLVEPLFTCLDSLFDESADEEDLKCGAQLIIGIGKLLTEQSAGETTALVMKCRQHLISNSIQKSEETNVLLVAVGDLWGAGWQKSRLPEILQNFHADKFSFVDHFARYNNSPTMLHRSRSSSGYGSPARIHPLQTATGSKRLIVESLRTRRRNNTVSSENSSNRDYNDNGDDTESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUW2</accession>
    <name>A0A914YUW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3934.t1">
        <property type="protein sequence ID" value="PSU_v2.g3934.t1"/>
        <property type="gene ID" value="PSU_v2.g3934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF244">
        <property type="entry name" value="DEGENERIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3934.t1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58525" checksum="B0040398EEF547F0" modified="2023-02-22" version="1">MNGNLQHKNGEGFSETQVVKRGIPKASPDPSLNDDTVSQKIPKWCDDGFELFKEHSTFHGVKDLSKANLPSTKCLWILILCVSIFFSIQGCYMIISEYLQRPVVVSYFVAEAHQNLALPDIIICPFNRFNRTYLDNLNITGDLAQYLELAFPGPAMFKFQEPIQQRVQSDVDKHDAIIAEIIKNMGNMSFSSFMKEASINCEAFFQNTEICKTATELMTSAGKCFRLPGGEQISDGFGYGLKLMITLPKHLYNPGANQMLNDGIVVKLAEPGHGVDHDLTFISSGVHAIMPLSATQYEFMNDPPRYSCLDDSAKNYSRLWCFEYCLTQHAEDICNCSLIAAANPRKPAICTTKQVIKCFYPSMFSDAKEAITAFQHCKSVCKAPCKYWKYSKTVSTANLSPEQAKAFTNDSEAVQELQNMIILEVFYTSLDYTVIKHMLAMTPSSFIAQLGGQFSLWIGGSVVSVIQFFIYICGGSYAHFYRTYIRRPTMQNKKYKNNLRLSNTYSDSDDKLSANNETRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVS7</accession>
    <name>A0A914YVS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVS7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4085.t1">
        <property type="protein sequence ID" value="PSU_v2.g4085.t1"/>
        <property type="gene ID" value="PSU_v2.g4085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4085.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17298" checksum="DD018C24FB0F0590" modified="2023-02-22" version="1">MKYLRLVAYASKEWVTCTPKDTLIEVGRCAASKNLKNSVDCTLSYETGTIDTESQSSGSSTTSSVSASVGVTLENLFSASTSLSQEWKTWQSTTTSHTFTKSQTFTIAITAEPGETVVIGQRIAACGKYKVSSSYEVFSEKLGNQLNRARRLISKVQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWB0</accession>
    <name>A0A914YWB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3945.t1">
        <property type="protein sequence ID" value="PSU_v2.g3945.t1"/>
        <property type="gene ID" value="PSU_v2.g3945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172:SF4">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3945.t1"/>
        </source>
    </evidence>
    <sequence length="356" mass="41083" checksum="41C9C876A8AD8142" modified="2023-02-22" version="1">MCGMPGTDSLCFDILVDNKAGEHQVDLEGYSAENYRRMPRLIDLRQIQGLNRYPMDLGDQYDKMIYDRDINSLQNLVMNGDYDKIEHRIFPPHSRDLARILANLNMRIKAIHQAAVDDDLPTMKQLVDSYEMATCRDAEGRTPLHLGVLFNREEICRYLLLLYPNCVDMPDKENRTPLQYANALSIFSDEDEEVDKEIEARIFSIDFELRTYKELEELQYQGKADQVWKIVKKHLGNDRLVKYIHAYRQVQTKLNNAFTAIEENDLTKLKSMLDVELIQSRDPKGLTVLHVAVLKERHEIVEYIAQSFPKYLNIVDHAGRSAAHYSASAKNAIYDTLVDAGADVTFPDKVISVFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWD1</accession>
    <name>A0A914YWD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWD1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4416.t1">
        <property type="protein sequence ID" value="PSU_v2.g4416.t1"/>
        <property type="gene ID" value="PSU_v2.g4416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4416.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32715" checksum="9015DD908758DEE8" modified="2023-02-22" version="1">MFYSFFIADCKCGDTVIGIQGGSAIRPCLYCIIPSNEWLRLDIIPDSALRKIEDIQKSGAIIEKAEEDSNLSVVKLRALKQQHNSVTATPLLTAIPISRFVPDAVHINMCAVNSIIQYCKKRPELASILLAEIENINVQLCPGRSEYNGPNCSKILKHFVDNPTIDGYGIDLLRLYAKVEAYAVARDLTEEEIDGLDQAIKDFFKLIDDKYPDLPGKKTKLHMLKHHVMPFVREHKSWGKFSAQALEASHHVKNVSDTRIQGKTPLAKSKQMDYYMNQQMLINYFTNADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXG2</accession>
    <name>A0A914YXG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B box-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXG2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g434.t1">
        <property type="protein sequence ID" value="PSU_v2.g434.t1"/>
        <property type="gene ID" value="PSU_v2.g434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="188"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="493"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="616"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="706"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="767"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="801"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="882"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g434.t1"/>
        </source>
    </evidence>
    <sequence length="920" mass="101914" checksum="69FBEFE7C0C40C36" modified="2023-02-22" version="1">MNKVCKTCFTVALQSNGFVPVDKCPICSLINTTPNLTSLLGNTNIRDAFNSQTVSPIGFNPSTPTNSQTSNSKSTADNTFSIWEPLPLSGISNNSRTQSFSSSSSVYPQKATGILPPTSAGYHHQHQQASSQVSSSSGSFHGYSNRNRQSIVSNRGNHTPSTPLGHSKALQFQFKERENNNEKSEIHRTNAKCTNCDEKGTVVGYCLDCKEYLCSECVMAHARVKITKEHKIQVIDEGFNTLQLQTVSTPPTRTQSDSASLKADSESPNSYTGNSFSSTTTSSCPEHDLYFVSLCTTCGGTHLCLRCLQNHSGHNLRILPVYEYQASLRRLVNESKNILRSLEDSKEGIKRMSERIEASVQAVAGEMRSVIHLHISALEERKRDLLQRVDSIHHTKIQTLNQQNEKINDKMTSLDSLIKYGELIFREIASAPSSLSSSSPIEEDPRFLECYEKLIKLHSESFIPLIPTANDSIRLKSIDPSILQSLKNLGQVESGLCPKSTQLLGTRFKRSITGRPCVINIQMKDVCGDPIGKESREQGGEFVATLYGPLNASPAIQHADIIDRDNGMCSLMFTPKRVGIYRLNVTYCQVSITGCPTEINVCSGRDYKDAQTQGQKFAFGKEGCGDGEFSRPWGICCDHKGRILVADRSNHRLQIFDGRGNFLMKFGHRGNRQGEFNRPAGKCILFDIFIPDNHRIQIFYDNGGFSHGFGSRGCSPGLFNYPWGVSTNSNYEIAVTDTRNHRVQLFTQTGVMLKICTIDSEIKRSPSSPRGICFLPDNELIVSDFNTHRLAVVNSNGEPRFFGLEGTAPGFFHRPQGIAVDPDGLVLVCDSRSNRIQVLNIYDLTVVAVLGNDTKHQRPDLLTNDKFLDTTLFRQSSTTTEQSQVTTPNANLLEHPMDVCVSPEGLVYVVDFGNNCIRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZU7</accession>
    <name>A0A914YZU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZU7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3555.t1">
        <property type="protein sequence ID" value="PSU_v2.g3555.t1"/>
        <property type="gene ID" value="PSU_v2.g3555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3555.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8808" checksum="5CD7131BA4A11630" modified="2023-02-22" version="1">MHRQLAEILIFQQPQHNDYSQYEMYLAQSSITTPIPTFAPPQPHHPLTDAAPINWPIPQSSLGGAAAANISHNGYALSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0K4</accession>
    <name>A0A914Z0K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ATP synthase regulatory component factor B</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0K4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5415.t1">
        <property type="protein sequence ID" value="PSU_v2.g5415.t1"/>
        <property type="gene ID" value="PSU_v2.g5415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5415.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25456" checksum="F28780275F24FFA0" modified="2023-02-22" version="1">MRRRFAENTSNTFYPDRVAILGPDLSCLEWLMECGATSVKMSDGVEINRIREMKEYIASHGFNLKMLPKDVKPMPPIAPNLLLHDITVAERWKYIPQVFIDEVDGTDAAISNEGFNYFYECRQVKKLKLNHCDYFTNDALKILSMGRTAKTLEDFEVCMNPWLSDGMVPALIKMKKLKRIHFYFLPYVSNRAAVVRQLKTHLPKCKVSFPELDKVGYGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0Q4</accession>
    <name>A0A914Z0Q4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0Q4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5935.t1">
        <property type="protein sequence ID" value="PSU_v2.g5935.t1"/>
        <property type="gene ID" value="PSU_v2.g5935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5935.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16066" checksum="892FA0CA00E659F1" modified="2023-02-22" version="1">MFNLNSLRQIIGAVYDELPNIPINLRADAVPSEERYKLGIYQICDINSQAFRYANQTSTRMSAVQQYVNENWETVTNLQENLTKLPQLSKQLDEINRSVTELERFMAQTQIAFLALEALDDQIKDLKVRRQLPSLMDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0W2</accession>
    <name>A0A914Z0W2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-threonate dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.411</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonate + NAD(+) = 2-dehydro-L-erythronate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57561"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:136669"/>
            <dbReference type="EC" id="1.1.1.411"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HIBADH-related family. L-threonate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.411" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z0W2"/>
    <dbReference type="SMR" id="A0A914Z0W2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5772.t1">
        <property type="protein sequence ID" value="PSU_v2.g5772.t1"/>
        <property type="gene ID" value="PSU_v2.g5772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050006">
        <property type="entry name" value="LtnD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043037">
        <property type="entry name" value="ThreonDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="11">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="12">
        <location>
            <begin position="172"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5772.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="30717" checksum="F06C97DDA71CDA58" modified="2023-02-22" version="1">MKTGSEFHVGIVGLGSMGMGAALSCVRAGLSTWGADLNSNACATLKEAGACGVSDNAATFAEKLDALLVLVVNAAQVKQVLFGETGVAQHLKPGTAVMVSSTIASADAQEIAIALAGFDLEMLDAPVSGGAVKAANGEMTIMASGSDIAFERLAPVLEAVAGKVYRIGAEPGLGSTVKIIHQLLAGVHIAAGAEAMALAARAGIPLDVMYDVVTNAAGNSWMFENRMRHVVDGDYTPHSAVDIFVKDLGLVADTAKALHFPLPLASTALNMFTSASNAGYGKEDDSAVIKIFSGITLPGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z123</accession>
    <name>A0A914Z123_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z123"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5595.t1">
        <property type="protein sequence ID" value="PSU_v2.g5595.t1"/>
        <property type="gene ID" value="PSU_v2.g5595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5595.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16144" checksum="3A26DB15C6541314" modified="2023-02-22" version="1">MMKVRASAIKVNAHINLVKYDHAIYCQNNGNNFGFALIFDHKRHCNYVFNMLEQKMIVKNAKNDVDIVENMFILPLINELRYYSQLNFDFRCFILKLLKSLDIEQKQKLAGVIIETKIDKSLLDCVFDGIEYNRSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3C6</accession>
    <name>A0A914Z3C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3C6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7202.t1">
        <property type="protein sequence ID" value="PSU_v2.g7202.t1"/>
        <property type="gene ID" value="PSU_v2.g7202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7202.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39523" checksum="AF8D35FC0C623E9C" modified="2023-02-22" version="1">MFQCFQAFGIAKNGRRSPPKSPSREALANQANVYRSQGKKGIGISGMTEAERNDFNQARIDFKAYQHLFFSEWRRRICHYLGSYLAEEYPWYAAWYFLESRAIYLRQLVRLRKIGSMEDLRFKDIVEFKTAVRALPTDFTLVQLIVDEQNVLWLVRCGYDLIPIVLPLTKINVGKDDISHRMYNILLENDQSVEGNVDKRNFWIVRDQLNNKLENLISDVEYKWLDKFRVLLIPFGNINAEIEKNLKAAKEILKNAGFSEERGKVISARLFLHAYQDDYKYLLSIFSFIERETFGNPINANLNERVYQNLTKTCPETFFEAYLKEDRFTVLIVSPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3D2</accession>
    <name>A0A914Z3D2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3D2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6401.t1">
        <property type="protein sequence ID" value="PSU_v2.g6401.t1"/>
        <property type="gene ID" value="PSU_v2.g6401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF105">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6401.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12964" checksum="9C2304FE66979360" modified="2023-02-22" version="1">MDINPFGILQDFLAHCFYKYGAFVSRHPNPFIFGPIALTLFLSLGILNVEVSDDLRFLYSPENSLSRFEYQIHQEFSGDSVNSSLIAVALEASDGNKNMLRKEIADTIRDLIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z473</accession>
    <name>A0A914Z473_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z473"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6686.t1">
        <property type="protein sequence ID" value="PSU_v2.g6686.t1"/>
        <property type="gene ID" value="PSU_v2.g6686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6686.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15335" checksum="F290B8D8E7334FD5" modified="2023-02-22" version="1">MRLAHRITYVWFCLVTSIVLLVIYLDGGLGNEAVVIFIIPLIFNIVAGAIIFIKYLSHLDMFLRNGPILKPLSGIKALYLGSMVISKTVFEVLLCLKLRGVEIETLYIFIPLWVLLVLTMIYLLSDVVVTHFKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z486</accession>
    <name>A0A914Z486_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z486"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7168.t1">
        <property type="protein sequence ID" value="PSU_v2.g7168.t1"/>
        <property type="gene ID" value="PSU_v2.g7168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF93">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7168.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37162" checksum="4E655884A549FA57" modified="2023-02-22" version="1">MVPSNKKKDMSKPIPEIIYNPNSQITYRRGSYLGKGGFARCYELIDRNKTVFAGKAVAKSALLKPSNKERMAQEISIHKALSHEHIVQLYTHFEDPDYIYLILELCENRSLMELQKRRYFVTEPEARYFMYQIVYAVQYLHERLIIHRDLKLGNIFINSNMQLKVGDFGLATQLTDRDERKDTLCGTPNYIAPEMLQRKKHSFEVDIWACGCILYTFICGRPPFETSSLQETYARIKHCTFEFPSVVGCHAAEVITQLLHPEPAKRPCAIDILKFKFFTMGFTPKDIPKSCLTTVPKLDGRQLCGGQMDSVSFFFYSKIGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z497</accession>
    <name>A0A914Z497_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fork-head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z497"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6822.t1">
        <property type="protein sequence ID" value="PSU_v2.g6822.t1"/>
        <property type="gene ID" value="PSU_v2.g6822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049624">
        <property type="entry name" value="FOXN1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46721:SF3">
        <property type="entry name" value="FORKHEAD BOX N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46721">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6822.t1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51540" checksum="A8D77DF9718A823E" modified="2023-02-22" version="1">MFGNGGIDDGHFPGMGFTDSLDGVFPDEILNGFNEDFNCNIDDFITDCSTINTNSVDCYFPTDNVQTEFLDGTEEVDFSQIKNEKPSSSKKSYTKQPKREQEECKNGFCKPNYPYSCLISLALKNSSDGQLSVSDIYSFVCENFPFFEYANPGWKNSIRHNLSLNKNFLKIEQDKNGARKSCLWQFNPEKLEKVELELNKYDRNEIVKSLRCPEDYILIMSGEKGMPPISRRVKTPDFANESNDNTPKIMKQVVDYFTDATADQRSKQTVRQVAEQALNKLLKVKSEPTTHPRIVLQPVTSKSSASRRQNLASTSYESSHSSSSDSNFSQKEYLYCQPDSSGVGEMLYGEVDYQTDENYTEFFDFSSYTNPNEAPSDENAFLSPSTLSNFSLNGNPFRPFRCDGSISIRPMKRPTNPNLRPIGTIKDGQFISSASKLVRLENDYDVSQSKENLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4D7</accession>
    <name>A0A914Z4D7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4D7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5115.t1">
        <property type="protein sequence ID" value="PSU_v2.g5115.t1"/>
        <property type="gene ID" value="PSU_v2.g5115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038101684" evidence="2">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5115.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12572" checksum="8C85EB7FA808B3C0" modified="2023-02-22" version="1">MKLIVVISTVIFVAGICSGKVLLKEEKEDDSMTEKICEMCVSLITKATTQIIEHEDDFKQNGGKICDVVTLGNDELDKKCHEIITDKVDDIIKLVRDETAPKDVCSTISVCPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z510</accession>
    <name>A0A914Z510_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase II elongation factor ELL N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z510"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5342.t1">
        <property type="protein sequence ID" value="PSU_v2.g5342.t1"/>
        <property type="gene ID" value="PSU_v2.g5342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II elongation factor ELL N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5342.t1"/>
        </source>
    </evidence>
    <sequence length="444" mass="48718" checksum="E1EB183294A20499" modified="2023-02-22" version="1">MLSRRTPHNVLGISQQQTSARQQPSGLSTNIIQLHNGTLPQGVNIKLTDDCFQNLQKAAQNGFDVLVHVNRKSITIEIKTNNATSLKFDCHFQRVSGNVIHALCKSNNTFNDVANISIRAQVKPTEQTFQSSRQKAANLSKHLELESNKCRTQMLSAPITKPGERISFKNKITVNRVGGIPKSIPNTPRNGSSSLGASTTLTPSSSSSNLISNISNKLGGGNNGSIVQRGPKDYAALKQQVIHYIASGRFKTQDEIVDHIMSTGLPPGIPPESAKRKIRETICEVAEVYVNPPKIALLPQYHREINIDWEYFSVEDRERVRQALSQTEITAGNNFAPMRHSRRGPFVAPKSKPRKDPATPAMTNSTTTSPDIASDASTCSTPSPVNNQMPIDSDYQITSKPEKRKLSSYDLSKSTTISPLNNDIAVPPPVKKASNESFIKFSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5X7</accession>
    <name>A0A914Z5X7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5X7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7314.t1">
        <property type="protein sequence ID" value="PSU_v2.g7314.t1"/>
        <property type="gene ID" value="PSU_v2.g7314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7314.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11563" checksum="EC51989C20DA2EFC" modified="2023-02-22" version="1">MEQLMDVEQLKKLTPEQQNQLIAGVKQQAAILNAQNLITELSEKCSNKCITNPGSSLSGGEKQCLTRCMDRFFDSWNVVSQTLQTRLQNEVGSAMASGSEYGSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z613</accession>
    <name>A0A914Z613_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial Rho GTPase 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z613"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7350.t1">
        <property type="protein sequence ID" value="PSU_v2.g7350.t1"/>
        <property type="gene ID" value="PSU_v2.g7350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000170">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Miro" evidence="16">
        <location>
            <begin position="9"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7350.t1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51272" checksum="DD6FE2D48799FDF7" modified="2023-02-22" version="1">MPDTIGNLTVDVRILVLGDKGVGKTSLIMALVEDAFCEEVPARVERVLIPPDVTPERVVTAIVDYSSRTQDEKALIKEIENSNVICLVYSVDDEKTVERISEYWLKLIQSTLGSDHERPIILVGNKSDKTGSADNMDKVLPIMNEFIEIETCVECSAKTMKNISEIFYYAQKAVVYPIKPLYNAEDKELTPKCRKALVHIFKLSDFDNDGLLSDQELNEFQTRCFDMPLTDVAIEEVKRAVIAVNPKGVLDDCLTLDGFLHLHQLFIQRGRHETTWAILKRFGYDQNLRLRENYLYPTIRIPTGSSVELSQDGIQFLLSLFTKFDEDKDGCLSQSEMTSLFSVCPTMPWTAEQLNSVETTSVGWITLRGYMALWTMNSFLNVTQTMEHLAYLGFNLAFRNQLAALKITRDRRIDIQEKSTTRKVFQCHVIGSKDAGKTVFCRSFVGKNLLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6P1</accession>
    <name>A0A914Z6P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6P1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8353.t1">
        <property type="protein sequence ID" value="PSU_v2.g8353.t1"/>
        <property type="gene ID" value="PSU_v2.g8353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8353.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17856" checksum="7EC146631B56302F" modified="2023-02-22" version="1">MKAETMWIIIGLVLLVVVIILACSGYWGCRYWKQRKSAAKTDVKTKQTLADKKISEIPVKQEVAVEEKVEKAQATKDETAEKIQPKPKKPKHEVQVGHPIVAKTPKKKTVVPTQEETPSGKTVEPTVEDSTHPSIIQNCAPTVSILKDPIHPPRPYGLAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z708</accession>
    <name>A0A914Z708_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z708"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7681.t1">
        <property type="protein sequence ID" value="PSU_v2.g7681.t1"/>
        <property type="gene ID" value="PSU_v2.g7681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7681.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15462" checksum="E0D79DDFA316A784" modified="2023-02-22" version="1">MLKQTWFTYYGDFECTCKQKIELSRYHEYLEYDVKKVHCLNCSNQYVLSWPQMMLPRMLNYHKSVTNFLETKSLHFITDSVAAVAIDAFTKRKTMTYQNKMVRKIVDFSSLTSPKARKLITESSSLNTVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8D0</accession>
    <name>A0A914Z8D0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8D0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8933.t1">
        <property type="protein sequence ID" value="PSU_v2.g8933.t1"/>
        <property type="gene ID" value="PSU_v2.g8933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002429">
        <property type="entry name" value="KETtiN (Drosophila actin-binding) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000962">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="59"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="228"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8933.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38440" checksum="11B4257B08F0B5BC" modified="2023-02-22" version="1">MTTVQAPKKYHDRVQIQIQHGFVVLSINEAQLSDAGIYQIIATNERGTAETTATILVHPRADILKENQGYDVEDVRDIQFSVSKGQKSAPQFLSQLSDYHCPDELGRSYFEARIAPINDPTLRVQWIKDGMALKNANRIQTFHNFGFVSLTLHPTYPEDNGVYTCVLINDLGEAQSSAQLTTISTETLQLDPMHEDSLQQINAIEGHEIHIGPILHERPEEFHSLEAPKVVRPLASKIEVEENEPIHMEARIQPASDVKMTVEWYHNGAPLPAAHRFRPMFDFGYVALDLLYAYPEDSGTFTMIAKNELGEAQSSLELVVTKQGTLYLDPQHPEGMLFFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8G1</accession>
    <name>A0A914Z8G1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAF3IP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8G1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8962.t1">
        <property type="protein sequence ID" value="PSU_v2.g8962.t1"/>
        <property type="gene ID" value="PSU_v2.g8962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.50">
        <property type="entry name" value="Microtubule-binding protein MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018799">
        <property type="entry name" value="TRAF3IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041476">
        <property type="entry name" value="TRAF3IP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040468">
        <property type="entry name" value="TRAF3IP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042576">
        <property type="entry name" value="TRAF3IP1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31363:SF0">
        <property type="entry name" value="TRAF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10243">
        <property type="entry name" value="MIP-T3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17749">
        <property type="entry name" value="MIP-T3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAF3-interacting protein 1 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF3-interacting protein 1 C-terminal" evidence="11">
        <location>
            <begin position="385"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8962.t1"/>
        </source>
    </evidence>
    <sequence length="609" mass="68775" checksum="F8DE7DCA3AA1B3E4" modified="2023-02-22" version="1">MVDVAKTRELFEPLIKRPPLTDQLLQRPPFKFIHDVVNETLHSTGFLLDLFTSDELDHTKAGFDKASKISFLEKLVDGLNIDGSLDDVKPSRIVAGKDPEMTNLLLQKLAVEAASATGATTKKHRSKSKTRSKSKEKIKDKEKEKEKEKEKEKEKTKEKEKKLSKSKSSSDETTKPKKIKKSSDKEKDKDREKKHRSKSKEKRSTIIEDSVQQPDSSYQTERESSGGTSKGGDDSGIAEETAESERHDHSRASSGIGQSRSSLPPDSGNLQNKYPVEADIIDEKPEEELLIKRPMTGAARPQTAMGRPGTAAARPAPPKVKKTKIADLDTTAVSQQTTIVDKSIVLMEEDEGAKKEAADDFIVEEEEIIAPIATTGADISELTEGAEHGQLVNRIIENTRKLKDEAGSFLDPNTFYDLSEQKKMRTEIEGVQRALQSTAQSTNPLTRSLDFIVEDFDLMLKEIEDNRKLTAQYQHQIHEKAETTGPFKDFDPENAGSEKRQALWKQSTELLISSNLFQIMQNLVQEYREVNPFTKTICVRSHFSLYRDISFVAIDHFKRNVDREQFDRMYESEFQKLPIRITPLLDPPDQPPKAAVIACRRIFMPLDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8I7</accession>
    <name>A0A914Z8I7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8I7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8989.t1">
        <property type="protein sequence ID" value="PSU_v2.g8989.t1"/>
        <property type="gene ID" value="PSU_v2.g8989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488:SF2">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488">
        <property type="entry name" value="ZGC:162509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8989.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39209" checksum="7BA76ACBC998053A" modified="2023-02-22" version="1">MEGVLYELMENVVNLTLKGTSEEMLAQIEEHIKYLSSACKYITASQSGQMLRKTCQTLIDALQKLKRNNSIEAFENAKTATALNLKAYEKIGEQAAEYLTAAASQHGTNSHPHNMSSEERQTLMRTRLDNLKISRENLAVERKLQESLRRERTEAHEKLCQIMINMERLNIEEVDLKDVVHYLRQGIQQLSRVQVAWGNIVTFFSRIKNTVDGPLMENIEYMTKNVKNISDKNITNVSEFQRLIILREITNASVVANVLMESASLYMNVSKQYVQPTLDKSIINMSLTQDEAKSKQCEIVTNFYEIKSAVENTIEDYSRQIQRKVYGALQDQDFYVGRFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8S6</accession>
    <name>A0A914Z8S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8S6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8312.t1">
        <property type="protein sequence ID" value="PSU_v2.g8312.t1"/>
        <property type="gene ID" value="PSU_v2.g8312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8312.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27615" checksum="6D013AE3C39E3B03" modified="2023-02-22" version="1">MGDRRSAIRSTDNRAEKHVAFKSPLMSVRSITPLSDMIQIDSFRSPTRSPQQQRFDSFRSPTRSPQQQQNHQQQRFQFQSPKRPASNPAQSGTPAKRRVPIDAPDNFSLSNATLDDIIVRNTLRVQMINEKVNGLYDQIPGIFEIADATLDKTSNLVIGLHDFDNEMHSYVDEEKEIARKLNQFLRDVSEAEELDLSEFSDDFEKIEEEIDNYDELLDDMLSEDEEDSEHDYDDDEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8T5</accession>
    <name>A0A914Z8T5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8T5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8321.t1">
        <property type="protein sequence ID" value="PSU_v2.g8321.t1"/>
        <property type="gene ID" value="PSU_v2.g8321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8321.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45891" checksum="1D133008B2EC72BC" modified="2023-02-22" version="1">MNENLYKFPSLSNLTPEEHRQLSHNACLTFHCAENLTVSSSAIRCHLNEHTLINPATGYRYHGAYFGPYNTSIDEFLKLPEISCIIYPITMTDGIQKIRYNRYRSYIIPLLYCSMSQRSCNKEKTLAFGGFTLKMLCDFFNNHDALSLYLGQKIYPRGHIASFNLSLLEALCCFCSREVVVRLSSSGKPSKIRLRNDPDLLLQQIENERALADDALQFYKRYLENNPDGLNWNELRIDSFDLGFNNRLTFVSSYPSYFLDNVYAALHHSKSVIDFETLCKTIVGYCDQAPDIRIFRRLTNISELNLLIEMVSPEALEAVETWKDNKKKILYMKIANELALKLNAIQVDFALDFIELFPNKSQLLISLNIWAVNRIAKCVLFASASHTFISEKEMVSKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8T8</accession>
    <name>A0A914Z8T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8T8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9086.t1">
        <property type="protein sequence ID" value="PSU_v2.g9086.t1"/>
        <property type="gene ID" value="PSU_v2.g9086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037874583" evidence="2">
        <location>
            <begin position="19"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9086.t1"/>
        </source>
    </evidence>
    <sequence length="664" mass="75026" checksum="0BD62C1825546D43" modified="2023-02-22" version="1">MKLLTFLGLCVILNLCLAELGSRKIPPFRPQKDEKNDEVFGISREKRGVFNKIPPIVPEEGDEISNGIVGGHLNKREQLQDVEVEKDGINLPVLLKTHRLRPGSGDDIKRIIDDYINAHKNGINLPILLKTHRLRLGSGDDIKRIIDDYINAHKSDNVVEDVQTKEEDVRILGEPLIGKNRHPKSDDTQKDHNIHKREAVEDENVGEPKLPGKNLIGKNRHPKGERVKDHGIEKRDVGVENDQSDDLPVLLKTHRLRPGSGDKINEIIQKYIESHKGEQQQSSDNENEQPELPGKHLIGGHRHPKSDDEKGHGIHKREVEAEKDGINLPILLKTHRLRPGSGDDIKRIIDDYINAHKSDNENVGGDGNVQPELPGKNLIGKNRHPDNKDDVKVNGNVESSAVNDNGPRILGEPLIGKNRHPKGGNTQNTQAVAEEDVDDDSDIRPLGMGLIGKFRRPRIFPDGKSRVVRGGGHNNEQQPGKVECKEEDRKQVLRCFRGYLKNYDLELVDGKLPTMREIYLKFKDVKDYEKHQKYFNDFSGCFKSTPETCFHADELSKISQQSGEEADYLATFFTVSEFSFKNKHNKKIAKCFIKQIEKCAQHKGSNFKECDSAKEIFNEAVQKFNVNCAKFEPQPDDLKTLLTPFLKRTTLGENCPNLLSEINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9E1</accession>
    <name>A0A914Z9E1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adiponectin receptor protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9E1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6867.t1">
        <property type="protein sequence ID" value="PSU_v2.g6867.t1"/>
        <property type="gene ID" value="PSU_v2.g6867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF127">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6867.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36124" checksum="299F606B0D19F5F4" modified="2023-02-22" version="1">MKNFDDDIVVEGDKNDVEKEKLKIDNIEIKESAKNSRKWTIKRFEALPLWLRDNKYLLSGHRPPLPSVLDCFKSIFSIHSETGNIWTHLLGCLAFFILAAWFLTHESDHINFQEKIVFSFFFAGAILCLGCSFVFHTLCCHSEQISIFFRKLDYTGISMLLIGSVIPYIYYAFYCRQTAKIFYISAITLIGFGAMFVSLSKKFGEFKYRTLRAGVFVAMGLSGVFPAMHLMYTDGLYKHINETSFIPLFLMAFLYIFGAAIYGLRIPEKYFPGKFDIWLQSHQLLHICVIVAAFTHFYGIQKMARLRLIEGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9N6</accession>
    <name>A0A914Z9N6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9N6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9036.t1">
        <property type="protein sequence ID" value="PSU_v2.g9036.t1"/>
        <property type="gene ID" value="PSU_v2.g9036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9036.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26157" checksum="C7BD128556EEAD11" modified="2023-02-22" version="1">MPQMVDLDEIKPISLENVIKLSLVGWEKAIIIFKQICFFSLKIAAPLKKQSRQNGIAPPIPSVICDSLISPNRDSSISPTVSTSSSRAAIVLGNLHQSLRRALNVHPEKYRSSRHRLYSRSASPFSGGQMAPARSRSIDDELNRRLKNRARGSLTQEYSGVATLKVPDETCFVTLNDRDFDGFPVEILCPDGTDYIFTDDEDDAIIPREIITINVSGLRFQTQEKTLKRFVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA51</accession>
    <name>A0A914ZA51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZA51"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9543.t1">
        <property type="protein sequence ID" value="PSU_v2.g9543.t1"/>
        <property type="gene ID" value="PSU_v2.g9543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9543.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21221" checksum="BA0BAFC1FD6009A7" modified="2023-02-22" version="1">MILISVELKRQFIDSKSNIVFCSDSSLDRVIKATKNCKNIHTIVVIQLSDRSLSYPEVPQGIIPYTSVISTLPQLNHRSIQVDVIRDIILLPYSSGTTGSPKGVMISHSNLSTMLSIFMNHFDKYVFSKITPDWDYGKEAMILSLPFYHAYGSAILMISMLKGQTGIVFSHFDKTVYLRSIQDYKASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAN1</accession>
    <name>A0A914ZAN1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8971.t1">
        <property type="protein sequence ID" value="PSU_v2.g8971.t1"/>
        <property type="gene ID" value="PSU_v2.g8971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8971.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45646" checksum="9C53119AE27622D3" modified="2023-02-22" version="1">MSGRGRRRQDESGEAESLTKEEDAIARFLRFNCPTKVGNCNGNDFSYFIGSKAIDTLLESKKYGAEGKDPKFKTKGDCDYFIRTLIEKGAIFRAKKVVLKKKTADDKRKGKNSLKKDDKIATTNSPRTKREKQLLKEEEEKRDESDSGTDAAKKDKDEESEEKKEKKKKVILVMQQNQSFSSDTSDVYAWVFDPTPLHKKIIGALMLVGVILGCLFPLWPDWLRLGIYYLSMGGIVFLLSIMGLAVARTILFGIIYAATFGKHHLWVLPNLTADCGFMESFKPFYTYEYISGDDKKDKKKSKNNSTKEEIEDTKEESKTVEKSETSKPPSSNEEEEENEEEENVQEEEEVEHGSESSGEVVQQQSFETVPADDFIPEQTNRRRHRPRREDENDFVMVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAX5</accession>
    <name>A0A914ZAX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAX5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7405.t1">
        <property type="protein sequence ID" value="PSU_v2.g7405.t1"/>
        <property type="gene ID" value="PSU_v2.g7405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7405.t1"/>
        </source>
    </evidence>
    <sequence length="925" mass="108528" checksum="29C7305A1A0A4DAF" modified="2023-02-22" version="1">MKSNKKAYAFVTFTNSTEKSIEIWNVTDARIDINKFDGDKFFDDACNYLLEMKKKNLEGIFFDLFEHENAEYLFNVRKDFLEFCRVKKILYRWIFRDILFSTMLLFFSEGDFKTEDTVITLWLKNDDFIFHRYRNGYLTQIERIKANDKKFEKKYDEIIHIKDPKFVVMGSTTVLKDVKKQMKAKDVLMVKNTFLECLQKSAAYLFGQMLRSQKSRWNFKVQMFNSFTLEVKDGPNKSSVSSSSIDALPYQFSLDLPKIVTSIRGSTKFLFGRHISFHDDLKIMVDVDEDGFVRFILPKLYVSSCSVRGSLDFMLYKNLAYMEDFVYITTSDSEKIILEAWRIVNGCLRKEKFTGESMFKDLDNYLTKLRKYSLDAVVSNIYKHSDPHFLLAARQYLQQFCKHQKIPFKFVTHESLLLSFLLVKSKLKFDHDQTLVIGYAYESMFKFVEINSTPSKFEISDTFKDISLDDSPDVLIELFTDILLVKFDHLILHFPDHLSILLLLQTCLGIQKSTRRIEESFEECFTTISANLFRQFFNNKNSKWNFVFPISPGVSLVAESENDYENLFYEPDISQYPCLKTLNLPKDALRFHVEQNFGYGFCIDYLASKKEKITVDMAEDGFTHFYLPSEFAKFDGGSMFYKEFGKKLNASILNRKPVIIFPEDIAILFVYENGSYNPIEIDGRKELRMVISFADEDPVFGDKAMEDKINEDGTFVVYDLMKIIKMDPKKVMKKDDWQFDIVQHNKFPILFEFQTPNGKSHASPSFLIAMILKQIAKIYKKKTGHALKDVMIPDIYQNKYAVIYIEEAFKHSQIKYNIYSKKMVSVLRSRENIFRRNSIPNSLQDPAAIKQQRERTSKIVFDQSKQEHFTATNGFHKLQKQIRGQWTIDVYAFLFNIYDDMTDSPCSWSVHSFPENSCKNGYFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB06</accession>
    <name>A0A914ZB06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB06"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9843.t1">
        <property type="protein sequence ID" value="PSU_v2.g9843.t1"/>
        <property type="gene ID" value="PSU_v2.g9843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9843.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16991" checksum="988FF3D97C06BA1A" modified="2023-02-22" version="1">MAQKWANQATLEHNNNREIPSGENIFWLSGVDGLEDDAINGTSNYWWNELKKYGIISGTNVTYLKGMTHAIGHWSQMAWSSTQFIGCGFTKFQKKNEDNIFYYYTVCNYFPSGNVIGMPIYEIGNSCKKDSECTQKSKSICDVDSGLCYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB66</accession>
    <name>A0A914ZB66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g99.t1">
        <property type="protein sequence ID" value="PSU_v2.g99.t1"/>
        <property type="gene ID" value="PSU_v2.g99"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g99.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17832" checksum="2604EFC65344E756" modified="2023-02-22" version="1">MIKNDKLIDIGIKNIPLAISFTNGRIQIGDEAVKLIKTQNSYVISDLLKILKTPSKDLKADPKWGFQISQINDETVLEFDTFKGRRKASPTFLFAFFLRYSVKIIEVISGEMPKTTVIVSKNLNDNFRQQLIASCKSAKINPTNVQIHEYKIVEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBE8</accession>
    <name>A0A914ZBE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBE8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9980.t1">
        <property type="protein sequence ID" value="PSU_v2.g9980.t1"/>
        <property type="gene ID" value="PSU_v2.g9980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF102">
        <property type="entry name" value="CYTOCHROME P450 FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9980.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58897" checksum="FD63A8C66126C599" modified="2023-02-22" version="1">MFLTILTLIFSSIFVFYCAAVYNASYWTRRGISGPKSKNAITNQLYELINAKYPSCFAIQDWTKEFGKVYGVLEGWRKVLIIADHKMAHEMFVKKFEYFHGRKINPLVGNVDKIKRVHVFAARGARWKRLRTIANPSFTVNNLKKILPTIEDSCNVMLSHFDKAYEMEKSFNIHPYYHELTLDIIYRIAMGQKESKQFENPNIDLVKAIFANFGLGPFTKAAHISPALGQFFRVLMMTIAIIKKNPFRQMVEKLYFAIEERKNERANNSTLKSDGPVDFIDMFLDATDENVQDEAYDKSGMKVSKKMTTDEIVGQCFVFLLAGFDTTANTLATTTWLLAKNPEIQKQLIEEIDEICSDEKVTYEQINELRFCDAVMKEALRMYPIASFAASRECMEATSLGEIPIEKGTFVAVDVLSLHFEKDIWGKNADEFCPERFYDFTVEQQMAYYPFGGGPRTCIGMRLAYLEEKFALIKILKKYKIVATKETEKELKMLGTTVLNPESVTVKLEKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBY7</accession>
    <name>A0A914ZBY7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7765.t1">
        <property type="protein sequence ID" value="PSU_v2.g7765.t1"/>
        <property type="gene ID" value="PSU_v2.g7765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF42">
        <property type="entry name" value="TRANSPORTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7765.t1"/>
        </source>
    </evidence>
    <sequence length="967" mass="110258" checksum="5F2CA6793E5D199E" modified="2023-02-22" version="1">MDNIDNVYQAFDCLSSQDTDQRHAADKWLLEFQRSIHAWSTCDKLLNDTERNYSATVFAAQTMRRKILMDFNELPQDNYDSLRDSLINHLKRLEPLDPVHYGTVVTQLALALADLYLQVPEWIGFIGHIVNIFATGTPGGINIMLSLLTVFPEELQGKDLRLGANRREAVQAELAGNFNIVVNLLTQVLNIDPNNTSIAKKVLQCINVWVNNPQNKTEGFAASPLLQNMLQLLNETNVQTDIYQANCEAISSTAFLAEDTRNHYQLAITLQQGIFATAQTFQTLMASEDFDKLASLSRVYIELAESFLEEIVNHTGGPLCDLRTIELVLMVVNYHDYALVELTFNIWYRLSEFIFQVTEDVNYAALMDSFRPYIEKYILALHRHCQIDVDQDGILDEKDDFSQFRNAASDSIKDVSFIMGTIALLKRILKLIQDNPSITWSELESALFIVSAVVNNVTNTQEEALPDFLHIIFSLPLNSHVSLLNTGAEFMGSFPEWFEDRNQLLNHSFRWLLSLCEHEELIKTTAESIDAICKIHYMFLREYFPALMTFLRSMERAHNYGPRMEQAAQAIIRYFSCAALLNDLPGADIVQQLEVLCDDSVRNLNELSNANRNGAPIVFNEDVPDAWKKAKSDPLIWLDRITSVFKTLKPWNSQKAFQVEHARHNGTPAMLETIPELQVPWLDLGRKIWNAISSTIEAYQDSSRIVEHACRCSRYLIRSMGMQSVRFVNDLATLIVKVYDAQPHSCFLYLASVIVDEYAVFDSVLPYLLEMGGVIARRSFQLFAKPNGLRDNPDTVDDLFRLAIRFVQKSPAAFFSIEFSKELFQCGIHALEVDHSEAHRSVTKFFTETIEAVRMAKQAGGQYPALDAVELLFTQYGEELVWYCLSGALFFVSHPLRKDLGEVLFELNRVYPERFSNWLRNGITRLQSERRLGATPAQLETYHARTISASRQSEAVTALRDLCKFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGG3</accession>
    <name>A0A914ZGG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9378.t1">
        <property type="protein sequence ID" value="PSU_v2.g9378.t1"/>
        <property type="gene ID" value="PSU_v2.g9378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF9">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9378.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18037" checksum="21479E88F67441AA" modified="2023-02-22" version="1">MFIEHMICSQELELFDLNDNKTLAFLETLVHISNSYGSVHKYLCLAICIIGSIANSVHLAVLTRPIMRQSAVNRLLSLVAVCDILTMISYTIFTLRFGFAVDLSDPPLGYALHWIVFLLIHVVCSIALHTITLYTSVATAYVRYKALKTVSSKWNRSEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQ92</accession>
    <name>A0A914XQ92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XQ92"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10191.t1">
        <property type="protein sequence ID" value="PSU_v2.g10191.t1"/>
        <property type="gene ID" value="PSU_v2.g10191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10191.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22762" checksum="FC9C7548A8A581EB" modified="2023-02-22" version="1">MAKKQYDLLFKLLLIGDSGVGKTCILYRFSDDAFNTTFISTIGIDFKIKTIELKGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNARSFENIAKWLRNIDEHASEDVVKMLLGNKCDMTDRRVISKERGEKIAIDHQIRFLETSAKSNINIDKAFYDLAEAILDKMPSQSSTNNMSIRPVEQESNKPQGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSK2</accession>
    <name>A0A914XSK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bindin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10958.t1">
        <property type="protein sequence ID" value="PSU_v2.g10958.t1"/>
        <property type="gene ID" value="PSU_v2.g10958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10958.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8076" checksum="EF0B0BD9680D37D0" modified="2023-02-22" version="1">MYQPPGSNNGNEGDLGQATPGQIPPLGFFNGQDVASIVASAASQNYGLMGGEGGGMDDPAQNEIFRLDKQAIYGLVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV42</accession>
    <name>A0A914XV42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sushi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XV42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10838.t1">
        <property type="protein sequence ID" value="PSU_v2.g10838.t1"/>
        <property type="gene ID" value="PSU_v2.g10838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF575">
        <property type="entry name" value="LOCOMOTION-RELATED PROTEIN HIKARU GENKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="205"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10838.t1"/>
        </source>
    </evidence>
    <sequence length="470" mass="51645" checksum="78C2E19B55468328" modified="2023-02-22" version="1">MGAFRDHFATTWSSSSHPQALRGYEKLDILGLLPNSSNALNDNSEYKCECLQEIVQLFDEQPGLGGDSTKPGLFGRLDHKLVKMGEESNQLFENYMRTGERLYCVPEFGQCGASIPLYQWFSASEIDNFVTTREELDLAHDTNIKSKGVLCYIWSHNYKSGQKAAPITDKKIIPKMDEKNNIPIAGGFQTYTRTGPSEIKKVTDLACPTLTATNGQWSYTSLMRTPGTIGFLNCNTGYAIINGTLAIVCQRTGRWLPEPPTCNLSGCPPIEHEHSNPTQVQGRIVYNSVVVADQRYPVGTTAMLICSERMDVSHNGADISYCTLSGWQPRKLGKCEKICPKIHVENANIVYADSHGLDQVTNTDGTIATLICPFGTNLIGKGTAECSDGKWDNENIGECKMLNCPVLKSIDGGRLTYYNAKSEPTNPLIVKIIPGTIVRLTCGSDSNLKGAGESMCHTTETWQPEIGICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVH0</accession>
    <name>A0A914XVH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10970.t1">
        <property type="protein sequence ID" value="PSU_v2.g10970.t1"/>
        <property type="gene ID" value="PSU_v2.g10970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10970.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12405" checksum="87784AFB35D91200" modified="2023-02-22" version="1">MMLRGMRYHPIDVETSVIRSHRRIAESAVFTWTSLLVVVAETDASEAEALDLVPAITSALLEDHHLTVGVVVLCDPFTIPINSRGEKQRMHLRDAFVKDQLDPLYVAYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVK9</accession>
    <name>A0A914XVK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CUB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVK9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10567.t1">
        <property type="protein sequence ID" value="PSU_v2.g10567.t1"/>
        <property type="gene ID" value="PSU_v2.g10567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10567.t1"/>
        </source>
    </evidence>
    <sequence length="462" mass="52278" checksum="4366C1694CAD74F0" modified="2023-02-22" version="1">MNCNYTILPNPLCLKAYFHIEFTNFLRVTVDDFVEFRWNGNVDLNVTSKQMSIINRYYSPPSNMTLQFHSGPSPNSITSEMQQWHFKLTSIVTPIFVRKTLDQTTPKYVQWLADMGENDALTVCILNGTLELLFTGDENTNLSEFLLYDSNDVNNFVGSLNSFLRASNPWLPARIQSTSKCFTLYVPLKSYAKSYTALFRIVEYSNLNCRGANNVFQVPYTYTYPPEYDVSVQSTTLGSCEMIILSSTGYFSNDLPHIWIKNISADSHSMYLFKSGINDKKLMNLNGSEASQWQSFGIYTSALIIVLPPSATITLHLSYYFLPREQINILKNGTQKGIMVSPSYCGFLKSFGNSSLYSSDNVISQISLNLDVKNIYGTLFPLLEYGIGQRLTINQSTNISSTGFNLYFNDNGKSKDNGFLIKYTIKPMVYDFDPTKTKPSEAAKRTAMGFIILIIITVIFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWI8</accession>
    <name>A0A914XWI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWI8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10899.t1">
        <property type="protein sequence ID" value="PSU_v2.g10899.t1"/>
        <property type="gene ID" value="PSU_v2.g10899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10899.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24645" checksum="4378D0CC0B3D5B29" modified="2023-02-22" version="1">MTVSSTTDIESQRSLLCGCCRFGSKKRRLNEINEARLFQPSTSTVPLALNESVPQIVISTPSINGGKYLFANGIDTSRSSNEIYTTARTSRADDIQQYTSMTELVRNIREEAGFQDTPRQISSDVGTTVSELRIEGLPELTSNNREPSLPSPSKEFYFPEASSSANSVSINAPSTISQQKYRPSINRKLNDLTVNVYNTFWRFYGFIITAIALILERILPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXA8</accession>
    <name>A0A914XXA8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10384.t1">
        <property type="protein sequence ID" value="PSU_v2.g10384.t1"/>
        <property type="gene ID" value="PSU_v2.g10384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="844"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1509"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="5">
        <location>
            <begin position="1825"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10384.t1"/>
        </source>
    </evidence>
    <sequence length="1962" mass="223498" checksum="FB9998EDCBB3FA87" modified="2023-02-22" version="1">MLDNSHEEDDAIITSPQKKKRKTKKSQKTKALERRTFDKIKRTDTTDLNDVQSTPKGRGFQSRRRDDAAPYPKKAATQPALPLTIGPISNLSAKKKKLGFQIISDVKQPRNDPPASSTLPLPNQYYDPMAQNEHADEQVDDVYVDDDGIFHVNDVYGVPENTVIQIDDVDNVNGGPLPVRNYHDPWYAGVDFLHADVEAALTAPSNSWANDAQLNAFLAGMIPHYAGRTFNRIAFLDSVWDPVFNADSRTPIRSFLRIYPDNPDAIISLVHTGNHWGVLLINPARHMAIFVDPNMQQWQTQIESTARQRCADILNALVNADIIDAATELIQAPPHTFNQQTNGWACGFHALICAEDFLEHGHLVRHPFLNINAERNRITLLLHRLYWVNRNRPDNVSGATVATWTEPPNRRDIILEEKDIPKKRMLAADNDLIKPVAAKPISNKPPKPPVKRSKRIQAQHKPPHPDVVKSKIRSLHQKRKPIALLSSEIYPDEDYQGPMNKRCPHCKAYLFANETSNKCCANGTVPPMFIPPAPPEFTNIARFDEYWTHTKPLNSLFAMVSTSANVQMNDGVFKIQGEPKHNVGDLVPRPGQPQQFAQIYTIDADEALQNRCRNLPTVGLKLKQQPRQEVLGLIEAMLREHHPLAMQFKMMKQQLEEYEAKCVEEGKEVRTLFYVWEDPNEPDQDRPGTANVHPGRLNVPSASGQVFAIYKSDDGGPPPNGLYYGYEKNGGNSLRFVPTYSGRVYAAAYPLIFMYGQPGWTPGIPKLNPNGPPQDQPPPAQQQSHESGDESDGMKDGAMVENSEDDFNVASCSSDDDEMADKKARNVSMNQHFRSQLFDRTKEQKEVFNPITGSRTLTNQYIIDKCLAVEQQRLEYMEKKIEENEWRYEDSKVLRDYLIQEINKDPTLKGKRLGKVRLMTRRYRGGKRYMHYKFHNGIAINRRHGRDDLFITFTGNPTWREILENLRPGETWLDRPDLICRVFNLKAAEFLKDLIKRGVLGKVNTYKLALEHQKRGMPHLHILLSMKKEYKPTTAEEVDDLIVAHLAEQPEDDDENYNANLRYFNSHLKLMIHDPSRCAAMCGKSKKNGICKKGFPKPYSDTTIMKSDGYAQLKRPEDGRTVTFKNGNRRPVDVTNQHVVAHNKYLILKYNCHINVEHCGGIRSLKYLHKYLHKGCDKGFISVRERVKVAKKNDKGAVELDEEGNPVEYVDYNELHQFRQLRVLGGAEAVESTFGMIVAKQSHVVRELPVHLKGEHNVSFKDSETGEEILPKTANDGTAPNARAVSELTAFFKLVEDEKADPLIDQNDETRAPNLYYHQVQEHYHYNKNKWIRRINDLKTIGRLQPVYPSLVERYCLRELLGTVKGPSNYEDLKTFNGIQYATFRESAVAYGLFVDDTISNLTLAEIVTYAMPRQCRQVFALILLYNQPEDAQKLWDAYKKQFLDTGTRFSEQVLERRALAHVASILFHHRKTLSNFKMVDVTDDELMQAINETFSDFDTDGDERYGMLNELQKFFVDVVLHSFQNKKNFDRKRLFFLQASGGTGKTFVFNTLIRILRANGYNVITVASTGIAAILLDGGQTAHSAFRIPLDIHEDARISATHPLAKMINAADCIIWDEAPMQHKSVLERVNKIIKQLCPETFVHHTAFANKTVVLGGDFKQLLPVVRRENMKAAYDASILCSDVFRDNLNALFSIYVLEHNERAKDDPDWAKFLHDVGNGLNFSPFGTDKIQLPHQIAEYSEQAVIDFVYPSEIFDRPYKEYFDWVKESVLVAPINDKVDELNAAITAKVIGAANTYLSIDTQIAAFHQGDEILREDYTTDELNMYKHASIPPHDLVLKERSVVTLTRNLDVHLGLCNGTRMVVQRLFENHVQCQILTGAFEGKSIPIFKITNRFTPEPDEDWPEFSRFQLPLRPAFAITINKSQGQTIGRIGLILTSSCFAHGQLYVALSRVRRRQDIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXL5</accession>
    <name>A0A914XXL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXL5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11268.t1">
        <property type="protein sequence ID" value="PSU_v2.g11268.t1"/>
        <property type="gene ID" value="PSU_v2.g11268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF41">
        <property type="entry name" value="BRUMMER, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="9"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="536"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="623"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11268.t1"/>
        </source>
    </evidence>
    <sequence length="662" mass="72964" checksum="131EA8AE93C54C42" modified="2023-02-22" version="1">MDDDNNYTLSFSGCGFLCMYHTGVIAAIKEYAPQLTKNKICGASAGSIAAAGIVCNICVSKAVSTILAIVSQARQKLLGPLDSSFHLMKLVQQGLEESMPSNAHELCTGKLQISLTRVSDGANVVVTDFPTKKDLIDAIICSCFIPFYCGTTAPSFLGVQYWDGGITDNQPIVDANTITISPFCGESDICPPDIDSASLFGFDFNGTSVRFTSQNLFRMFGCLIPPTPENCSRMCRQGFEDTLRFLTRSGMTPCARCLTIQSSALPLPKYDSYIKTRNSSSVSLIPRARMGSECDMCFDKVESKINSSHTTILFPPLMQRTLDEAAAAENWLFNYLWKFRLVRYTWRFMIPAVMPMQYTLFGLRRIAAWIASLPQLNAMLRRFKEMLYFVVSEIERIYGPITQLSCYFSVTEVKKPDASNSQLVTVADPTAASEITSYTGSTEEEDSINHLVQYSQEHDAVLAFYYTDDNNRTQVCEIFDIENPNRVSNCHSTDCHKHHGRHSTPLPPIIPENDDELEQEPIDIPNAIKSSPAFAEDSGLSLTEDNSIPSSTNKRDACCSPVRHLSTGSRSSLRGRSNTASSSSFRRSGALRRSVAGRISNGIPSNSMEDGCGLIVNNNSNNIFSSDSDPDAVESVVTNRRKRAASDDYDGGPEQSDTDHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXU1</accession>
    <name>A0A914XXU1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prolyl endopeptidase</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XXU1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11348.t1">
        <property type="protein sequence ID" value="PSU_v2.g11348.t1"/>
        <property type="gene ID" value="PSU_v2.g11348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051543">
        <property type="entry name" value="Serine_Peptidase_S9A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757:SF19">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757">
        <property type="entry name" value="PROTEASE FAMILY S9A OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11348.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17435" checksum="871557FE30A1249B" modified="2023-02-22" version="1">MGGSAGGMLMGVAINQRPELFHGVIAQVPFVDVVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDDHLLLLCTDMDSGHGGKSGRFKSYEGVAMEYAFLVALAQGTLPATPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY64</accession>
    <name>A0A914XY64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11474.t1">
        <property type="protein sequence ID" value="PSU_v2.g11474.t1"/>
        <property type="gene ID" value="PSU_v2.g11474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11474.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14589" checksum="BBD4EA09FA9C2A75" modified="2023-02-22" version="1">MVFSVVYDGNSTNCGTDGRCPTGSLCVRPALFHEPHFCLGETYRLGAFAASPQKLYCSEIDEPPLSTAVWISLLWAALIVGFIIGQFLRLRSDSRESPRETPMRNLHSPEYESPYRAQEHYWSQTNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYL3</accession>
    <name>A0A914XYL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYL3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11623.t1">
        <property type="protein sequence ID" value="PSU_v2.g11623.t1"/>
        <property type="gene ID" value="PSU_v2.g11623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11623.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25348" checksum="1DC6681C79D2382D" modified="2023-02-22" version="1">MSSKSILLVARVYNVAIINALYHSQLIYDRRLYIQKAYNHFEEDPPDYFQSSEKIWAGCVHEVKSTFYSLGYAVQSHRAIAKIQNLSIVACDNAEFSLRHPGLLLKLKDGWTSAQECHRFRYGDNPFDIRDFPTKLEDAKYFIMNFDKLDKQMIQKAMIKLINRFEAKPLEDEKEEKERKLKLMKYGLCVQRTHIKERFFLNGKQQEQITHKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYV3</accession>
    <name>A0A914XYV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g13121.t1">
        <property type="protein sequence ID" value="PSU_v2.g13121.t1"/>
        <property type="gene ID" value="PSU_v2.g13121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13121.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16531" checksum="3CFC833032FFC035" modified="2023-02-22" version="1">MNAHSSLSLYIASYENSTEAEADSEDDKKRILKKKDVKENFIKKWKIARNSSSISHNPFEFPRQQENEQSNVPEIAPFKASQKLLNPNQVNQRYKTNTINMPIFCFGFDSESVANSLRAGMCGTRFLXXXXXXXXXSISKITHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ89</accession>
    <name>A0A914XZ89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ89"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12275.t1">
        <property type="protein sequence ID" value="PSU_v2.g12275.t1"/>
        <property type="gene ID" value="PSU_v2.g12275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="65"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12275.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26195" checksum="E829671C6DA10012" modified="2023-02-22" version="1">MHFPQWVDLKGQDVAPDTVHQIVCMVDPIADKSWIRIRSKRGSSIQTDGIHEKDKIYPGSEEQETLSEGVKVLKGEYVVKAIRQFDMDQCIIFCRTKLDCDNLEAYLKIQQKDWSCACLHADRSPDERTANLKKFKEGEVRFLICTDVAARGIDVRGIPYVINMTLPPPEDKSSYLHRIGRVGRAERMGLALSFVATVPEKVWYHQCRQRTCSDTRRCAIWYDEISVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y031</accession>
    <name>A0A914Y031_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y031"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12577.t1">
        <property type="protein sequence ID" value="PSU_v2.g12577.t1"/>
        <property type="gene ID" value="PSU_v2.g12577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF378">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12577.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24228" checksum="80B1F4354C1A7608" modified="2023-02-22" version="1">MFIAPRSLLNATPLPLKLFICQFLWILPYLFFANYLERSLLPFRFFCYTDSDFLNVQKPIRQPLSACIKHVFPNTIPNSQCSLNQNIKAKITPNLPTNFEKIIVIRSAPNAINYRDYIRETWKQTFPSEIPVIFVVGKGKSDEVFLEAEKYADILQLDFIDSYFNLTLKMMATYGYFLKHSNVEQIMVINDDTIVNATALMAHSNVSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1E8</accession>
    <name>A0A914Y1E8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1E8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1165.t1">
        <property type="protein sequence ID" value="PSU_v2.g1165.t1"/>
        <property type="gene ID" value="PSU_v2.g1165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000006">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="475"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1165.t1"/>
        </source>
    </evidence>
    <sequence length="664" mass="75456" checksum="F0693F6F997E5088" modified="2023-02-22" version="1">MATNEFTKKLRAAIKTKIQELGIEVDDELPDYIMIMIANKKDKAKMKNDLMLFLSDNTDPFVDWLFDFFEKVNKKENEEAKAREPEKPVVKKRHSSEERQIKSRSRSPVRRSRSRSARRTRHEEEKPKRAPIRAPSPKRERSSRRRDERRRRSRSADDDRRSKRRDDRKKITYSDEDDEEPQRTVKSHVVVAKAERPPSPKLASQVVVKRRKADPIDAKAGSSLFKRALTDTLRDDEQPQTKYRRREGDVLQVNSLRTSRRTVTQNEDESDISEEEEERETQFIVKLGKGAITRKTIRASMDEAPPGDENYAVQHAAEKVLRRKRRVDDPGTTVASLAKHWNGKIEFDDDDEEDESDNEAEIDAFLASAHDSRIPPTEALSRPLQYIVPQKKQFGTSKPPEVGKIAERCKFWPKCRNEETCSYSHPSKPCINFPNCWFGDKCMFIHPQCKFEPNCNKPTCPYTHALPRPIAPRAATALPPRQPHPLPSATPATGSDSSGNASAPTNANSEPSKIASEPNEGQNSSEQQTTEEQNGVTIHENSGDTEVEQQNGETKPAAEIQLSESQTTEEKAEEAVADSKSGVPDILVSKAPTLSKPSAMSIQSASTQLTSTSNVMCRFAGRCHNEGCSFRHPKRCRYDEACTNESCYFWHPKKNAGRFRWVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1Q7</accession>
    <name>A0A914Y1Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1Q7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13392.t1">
        <property type="protein sequence ID" value="PSU_v2.g13392.t1"/>
        <property type="gene ID" value="PSU_v2.g13392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13392.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="29408" checksum="BA96C52E7C211A2A" modified="2023-02-22" version="1">MLPFTFESAKVSDLCTFVAEKCFCPPGSTFKVSVKSLFEPGGPATAMYYTVSPSVDLEDGSEMFVVVGKHIFIVQTIFKKLSDLPSGDAASFQLPLASPSRPHYSQSQPSTPRFSQAASMDTSFESLFGGSSHLPSSSQCSIPSTHGPTATAVATQSDDANFMNQVNALLASQPSVPSSTSDATATVTIPAATLLLAVYFSQRQTVEAAYLGMKPDDPVLINNVDVFAFFDNPTRKSALVVLQNTAAHSAEIRDAAKVLAKKSLVEILVKAYPEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2Z5</accession>
    <name>A0A914Y2Z5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyruvate kinase</fullName>
            <ecNumber evidence="4">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y2Z5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14549.t1">
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        <property type="gene ID" value="PSU_v2.g14549"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:potassium ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
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        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="13">
        <location>
            <begin position="57"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14549.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15371" checksum="ABCA04B369674FB2" modified="2023-02-22" version="1">MSGEHVLLTEQEIAFQKELEEAAYSRRQEQKIDVLPANTYLDHLCKLNIQEAPHVVRKTGIICTIGPACRSIDMLQQMIANGMNIARMNFSHGSHEYHGETIANVREAASSFSDHRIVAIALDTKGPEIRTGLLAGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y348</accession>
    <name>A0A914Y348_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y348"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13658.t1">
        <property type="protein sequence ID" value="PSU_v2.g13658.t1"/>
        <property type="gene ID" value="PSU_v2.g13658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13658.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18198" checksum="90EE72D55AC5DBEF" modified="2023-02-22" version="1">MDSKKAMVKAVEEQENKTESLTDKVKQALDTLADKIVPDAERNNNTKIMAEMNPRGAEIYEHGYATSVGGGNETLPHEAKKGGGLMNTIKENVKTITDAVTGNADPHGDEYLPANDATAALKNQDRAAPIEGHQEMRQERNHDHAKDESCSEAKGQKSCLGLSCHTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3F5</accession>
    <name>A0A914Y3F5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM Spen family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3F5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12294.t1">
        <property type="protein sequence ID" value="PSU_v2.g12294.t1"/>
        <property type="gene ID" value="PSU_v2.g12294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="209"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="292"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="SPOC" evidence="9">
        <location>
            <begin position="432"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12294.t1"/>
        </source>
    </evidence>
    <sequence length="845" mass="96645" checksum="27A26ED8B3CE9189" modified="2023-02-22" version="1">MARRRHSESRSPSPEDRRRSSKRRSRSADRNGSTTRREGSPHLSKFYRDRFGNQSPDSYNNLRISNFDRKLSNEDVKEILESEFAKYKKFEIKLVRHNGDEDRFAYVNFEENGPAKDIRRNKLPTLIRKLGSRVCLDPTGVIRDQEGKYIPDRYNRSLMDRRDHTPEPRREREPAPRERRRSPPPPASNRNRGRSESPVFHLNRDEPTRTLFVGNIPGDAKETEIREILSKFGELEDVEIKYKQNGDASYAFVLFTSIDSADECQKKLNDKPFRRGSEKKFKIGFGKAQISRRLWVGDLGSWTTREMLDKEFDRYGPIEEVEYKDGAEHAYITYNDITAATDACKGMQGTTLDRTHRISVDFAKISRDKARKRQHSSSSPDDSKRRKGGPRTPSQSDDSRTSSPVSPRPRSANESVGNGKSAAAVANKVETVDELRDQYAATWKGPISLKKSDYIINLHRVAGKESVLQDFLRDEDGRVLKLNINQRLPLDDSLFDKITTMDMNELAVCIGAEHDRSLSGLITYLREKSFSNLCGKMSKNNLLIHYSSNDSSENVVLSFSTEKDCKEIHLGILKQHQVTVKQEFFDDDTCIPSLNETDINDILNALDDAIKRNSNASGRLKRGVAQMLNHQPSQKEVVKSEFSSFEVQTNQDSQESIQSPVDGIRSRKRKYSSSDEYKKEKQCKLEITELDDVSSEVPTFELSFDDNYSTTTTQSTFTFPSNLCLQHSIPAKNVDRVFFPTWMNVAELRRFHRKNLPQSLLQSLSAGEDGFIKILSADKHIKEINIKSEPSIPEYENDCPYRDVSALSASKNGTLLFFEYSEEHPPLLNQPGMASKIRNYYKTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3J1</accession>
    <name>A0A914Y3J1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3J1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14014.t1">
        <property type="protein sequence ID" value="PSU_v2.g14014.t1"/>
        <property type="gene ID" value="PSU_v2.g14014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01012">
        <property type="entry name" value="YcaC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.850:FF:000001">
        <property type="entry name" value="Isochorismatase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF17">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14014.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21949" checksum="4D6D340C00A07EC3" modified="2023-02-22" version="1">MATRLLQRVNSKQAALFVCDLQEKFSKNIKYFPEIVQVTRRLIQASTILDVPIIATEQYPKGLGHLVPELGIKELNIPVYDKTCFSMCANDIMSDLEKRQIHEIILCGIEAHVCIYQTCLDLLNRGYTVHVVADACSSRSMTDRIVALKTLQQAGAYLTTSESMILGLVGGSDHPKFKEIQKIIMESAPDTGLLAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3X4</accession>
    <name>A0A914Y3X4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3X4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12454.t1">
        <property type="protein sequence ID" value="PSU_v2.g12454.t1"/>
        <property type="gene ID" value="PSU_v2.g12454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12454.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28445" checksum="91A3FCF82E05FDD2" modified="2023-02-22" version="1">MSEEIESSIIPSEAQEEEVVPTRDMSKYKDKLRALHKKREESRKINHEHVVEEDRLKKLPKNFVQKRQRQEWELEELEGKKVAEESGVDYDRVKSLHMQADIAEKLEAAKRRKKNPDTGFANYEAMSMRQYERLTNGIKPDMESYEQMKQVVGDDQFYPGVNTMIQGSHYPTKTALDKLSGDVHTQMKKRDQYHRRRMFDPDAPIDYINERNRKFNRKLERFYGPYTDDIKGDIERGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y406</accession>
    <name>A0A914Y406_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y406"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12481.t1">
        <property type="protein sequence ID" value="PSU_v2.g12481.t1"/>
        <property type="gene ID" value="PSU_v2.g12481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="1">
        <location>
            <begin position="4"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12481.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="34024" checksum="F7DC8F2FDFAA01F6" modified="2023-02-22" version="1">MFAAVRNLREKLAKTKYNDLLKVIINESVLNDPEVLPTIIDFIFDKVIEESTFAEFYSNICMELELYVSEQNRDTTNVISLFIAVSQKCQNIFEAELTQFLQSIIKTENQLGEEKDPKKCSYLNKQLDKVIETKKHQMFGIFQIIENFIDILFKNVETSRNELMIELVVELIKNIIPFVKRNEGSFLKCWIDDLCYICNIKRTSSNETKVMLKNLTKIINQKVIEINDAAEEIVTKDDRTSTYIIRKWFEGIDYYEVQQNLQPQQPKSISCSSSVKSYCIHCNQSTTTPETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y484</accession>
    <name>A0A914Y484_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y484"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14040.t1">
        <property type="protein sequence ID" value="PSU_v2.g14040.t1"/>
        <property type="gene ID" value="PSU_v2.g14040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14040.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="59395" checksum="B520B8E3CB6E85A1" modified="2023-02-22" version="1">MEDEVTVKEVDDYISARIPELPAEDDKSPGAEQQKLYHEMVLKHMLHICNTNSACQVNGRCTKGYKKNFSCSTIIHAHKPPDYQRLKPESAASSETKTDSKNAKEEKIKVNASQDNMDWEDDSIFNELKEKTENENAKEKVKVKSETFEATVEDDWEEELPFFDELRKDFDEELSHVEYKRLEPPPKDVEVTEETKHLFGFTARKTIKGKTDLVVDDSVVVPHNKFLLLKYDCHINVECTIGQTGSPKYTCKYVTKMGDVVCAKIHKTKLNKDGEEVIDFDEGERHLIGRIMTGCEGWMKSSNCWVIKQSHIVECLQVHLEGDNTKVFEPGYEAEAAEKDDKSQLLAFFALCKKDKYAQKYTYRDIPQHYRYTNGAWVKRKITPSKFLVRIRHVSPRNSELFALRMLLMKVKGPQSFEDLRTVKGEIFPTFLQTAQKLGLWESDELHMKAIQEAFTEMRSIKQKRFFFAMVIAFNNPGNPDAFLKKFLDDIFDLPGQDREKTYEKRYQKGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4N4</accession>
    <name>A0A914Y4N4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y4N4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12682.t1">
        <property type="protein sequence ID" value="PSU_v2.g12682.t1"/>
        <property type="gene ID" value="PSU_v2.g12682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000001">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12682.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18093" checksum="D45D99669D8BC7E4" modified="2023-02-22" version="1">MSELKKLAAFACGEAYIRNGQKIGVGSGSTVKYFVEFLKERYQSGKLKDIVCIPTSFMTRKWLLDANLPVSTLEQHYQLDIDVDGADEVDAKLNLIKGGGGCLTQEKIVQSCAKKFIVIADDKKKSKQLGENYKNIPIEVVPAAYVPVKKWIEELLGLFFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y648</accession>
    <name>A0A914Y648_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y648"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14721.t1">
        <property type="protein sequence ID" value="PSU_v2.g14721.t1"/>
        <property type="gene ID" value="PSU_v2.g14721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14721.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13693" checksum="86A117FB0EBB5A78" modified="2023-02-22" version="1">MPVIHIYQQPRLKSLFTKISCDPFCYFLIGIENGTTLGFEYALPFFTTATNIKLNELDNYFESLVTSLPGGLFVTGILVNDKVEENVVNEIFNKLTKLGPKLKFGSSNLGRKLVQSKGVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y767</accession>
    <name>A0A914Y767_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RecQ mediated genome instability protein 1-like N-terminal helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y767"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13474.t1">
        <property type="protein sequence ID" value="PSU_v2.g13474.t1"/>
        <property type="gene ID" value="PSU_v2.g13474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681:SF24">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="82"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13474.t1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56495" checksum="F9CF5FEA99634774" modified="2023-02-22" version="1">MTALKTLRDDGWKVDEIKFREVMGDTFDEKMSKDELKKVLSNLDIKDYSEAFLSEGISNKSLKGPIIVQLSKWENVSYPKINEHVQNNGVCSLILTDGAKSTKAMTTEPLANISGETPYGTKILLSGDIKLENNILQLNPKNCKFIGGTVEKMVEKWKTERFSSKQDARNTSDAPKWSSISAQGVVAPKKEKDNFKSMAAATESKPSENSEFEAARQQEIANLNALRKNTHIASVKLPENTKKDNIVAEKDNVSKNLQSEGYPKQERYEGKQDKYDSAPKHDKYSNNDNDNGSRRGNNFRKGRSNDNYEDIRTYTSRPSTNATLFDHIRTQMVNPPPETEFKQYDNTEVNSRDNNSQYNNRGGCNNPRQNSSSAAARDGFSQMKISDVPQNPRRGGDNYRNGGTRGRGAGGARGRGRGGKPFYADYGNPYQQPPQFQQQPQFRQQEFPPLFAAPPRPTMFPPPTAGYAPLMSQNIRYPNVPGTETGKQMQPPFTENNVRKTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7M3</accession>
    <name>A0A914Y7M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7M3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13608.t1">
        <property type="protein sequence ID" value="PSU_v2.g13608.t1"/>
        <property type="gene ID" value="PSU_v2.g13608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="30"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13608.t1"/>
        </source>
    </evidence>
    <sequence length="574" mass="65375" checksum="16E60FADA7469944" modified="2023-02-22" version="1">MSAAVGGKTGMQTRPSLDLPPLERFTDWVRCICVVTFDLELGQVIETIYPGDVELTPQEKLNICYMAFPDSNSGCTQDTTYHFCTRQSGISLSASQEQYCRQAPTFLQINPNFLYGFVHFRQQKNPLLPRGYYQKSLVVLTVLPLFGLFYHVVDTIAAQFFDNGEVAIETGCHHIDHWKLPEPGEILKLPFMGSVIHCRIPLRSDTPQKQLFMDTSSYQSTSGPPIVLPTIHETNFYESLKSSLTHCQMLWELVLLNEPVVVMAPTPSASSSIVQSLCSIIWPLNYASEVRPFFTIHDSDFMEITSKVNRSGILLGLTNPFFSKTLCDWPHILCVGDANGGQMLNAEKLYKKPWDGKTLDSKPGFYSQYKPYLYTDKSLFKKLVNIGSRPDNVQNAILRRHFLELTQCFMIPLERYLSTLIMPLRKQISLFKALPQTKPFCFDDFLQMLQQSGPTLSGGIKGDIEGLYRKFVNCSNFNSWLKSRLEDVDRELRESHLEMLCNTDLSHDIISTRQQVEVVDLVLKLKDKLKDLDGKSNEKRRKLQNQLNSVMRSVDDELKSLLLSNGALREAFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7W2</accession>
    <name>A0A914Y7W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7W2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14839.t1">
        <property type="protein sequence ID" value="PSU_v2.g14839.t1"/>
        <property type="gene ID" value="PSU_v2.g14839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14839.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="20912" checksum="7B90979B94F95D98" modified="2023-02-22" version="1">MKKLTKLIKFLAGNYLLSIIRFEGIEDQRAAKLFNFLQILTACFGGFAHGGNDVSNAIAPLVSLYAIYSEGSVNQVGQTPVFLLIFGAAGMCVGLWILGHRVIYTVGENLTKITPPSGFAIEFGAAVTVLVASKFGLPISSTQCKIGSVVAVGLVQSSKSAVEWHTFRNIAMSWIITLPVTGALSALVMAGLRAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y935</accession>
    <name>A0A914Y935_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y935"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16705.t1">
        <property type="protein sequence ID" value="PSU_v2.g16705.t1"/>
        <property type="gene ID" value="PSU_v2.g16705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16705.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11141" checksum="49DB37A05B61ACBB" modified="2023-02-22" version="1">MPFQSLNQFGSSFLTHLRGASLPVNMLKHVYLIDTPGILSGQKQTISREYDFASVVRFMADKVDMIIMLFDTSKLDISDEYKLVLQHLKGNEEKVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y957</accession>
    <name>A0A914Y957_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y957"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15977.t1">
        <property type="protein sequence ID" value="PSU_v2.g15977.t1"/>
        <property type="gene ID" value="PSU_v2.g15977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037747205" evidence="1">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15977.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20586" checksum="BE379BA8576ED90C" modified="2023-02-22" version="1">MVLFFLIDSGILYLSDGRRIQPSGFPIDPAFKPIKIHPDFRLIMLANRPGFPFLGNDLFAVLGDLFSIHVVDNPSRASELAMLKQYGPNVKDEYLQQLVSAFDELREMADNSLLTYPYSTRELVNIVKHLQVYPNDPLTVVVRNVFDFDSYTKETIQSIEAVFQKYGIPLGMDFVDDKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA54</accession>
    <name>A0A914YA54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Munc13-4</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the unc-13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14398.t1">
        <property type="protein sequence ID" value="PSU_v2.g14398.t1"/>
        <property type="gene ID" value="PSU_v2.g14398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08676">
        <property type="entry name" value="C2A_Munc13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04009">
        <property type="entry name" value="C2B_Munc13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF9">
        <property type="entry name" value="BAI1-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="97"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="9">
        <location>
            <begin position="616"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="10">
        <location>
            <begin position="850"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="974"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14398.t1"/>
        </source>
    </evidence>
    <sequence length="1140" mass="130427" checksum="68C24C19EC88902D" modified="2023-02-22" version="1">MKKHKRVTRSSKRVQASDNYFFEQFQPKSLTENESNIVDPSQLTIVKLSINESNETLHDLYVEALYTIVHKVGKSTNIPETQLIKYAQSAFQIDEFWHQKLMDKARKEKPPIVLLNVHLLEARDLIAKDTNGFSDPFAMMGVIPGNRKKDGGIIEENSGGEDDTPPTSPNSVNKESHQKHGGMLHRFGGSFRRKIGSKRGTKSGTKGIPAKLIKASSVQMKTLNPKWNEKFQFIVDDVNADKFHLDIWDHDDEDRSVLDAVSSLNEISGLKGLGRYFKEVTQSARAGSGDLVDDFLGSVTIKLKDIPSAGFEEWFTLDKRSEKSDVSGQVRLRLWLSTKEERLNEHDDESVDVKQHIELIRQFALQEIRMSGAPVSFFQGNLPEAALTILHQHAIQGDLTKLHQIMCQWLAYSAMINIGISFAFLNEILNKLISKWLPLQLDKSEENMLAESFVMFVEHCKKSIENHRKTITVNKRSHLNSFESMIQCLKLLYESEVFSKCVPFRRDLNDEIAHILTISAKKEFDEYAHMYNDDSKPALELYNILSALVASCRKFTYFEHIFKEQLGIEAGPLVYREFDRLMHEYIFSELMSEKKGDLKMEIINVPENEAVLINLLKIHFALNEFREFRQSKQRYKMDAIDWDNAFDRNIGKWIDIARNKAFARVDLACQLDAQIQITNSDVKHTSSYVDVCHIIDEMVTTWEKAKVTDVTLCAELTEKLVNCVCKIAEFYVDRVMAQLATDGFCGQLQPFLPPALVNIFCAAINNAEQVRRSLSITEKLHLDELSEKYEKLHTKESPFRATIDKDLDTCEKYLSEQIECSIDRLVIRQLPQLKKHVFHLAWSPAACPVEQALKPLTDMLDSELSSVHRILLHKNFVRVMHRQVGHLLQLLHDCVNENEGLEPTFYQRLSDAWSILMDYFHASGKGIALESFELIPSHKKLVQKLSLNQMTTFKLVEQYYKDLLQEQNDVAECKYGILNVRAYYNTNSQTLVIDVIGAKQIIPLDSNGLSDPFVVIELVPRLRYPTQNTIKTKVVSKTLNPIFDETFEFHIPPKIPPSAMVHFIVMDHDFLRSNDFAGEAFLDLTEVPGFGTAGVSNTLRQFNLVLIHPQSNHQDAVAVLESRKEDKDAQEFVKSLSVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAA0</accession>
    <name>A0A914YAA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14444.t1">
        <property type="protein sequence ID" value="PSU_v2.g14444.t1"/>
        <property type="gene ID" value="PSU_v2.g14444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14444.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27642" checksum="8F9ACE1F6AC43AE2" modified="2023-02-22" version="1">MENATSESIIFSPTCILTELSLLYIGANGKSADEIHEIIGKDLSKNEIIELLAEKINRHKKAAFGIQDCTVTFANKLFYSELCEIVSEFSEILKTKLYGEIQAIDFTSKNLVAKELNKFIQKSTKNQISNAIKENEIPDGTDLALISSLHFIAAWKDSFEPRRLETFYSTPERKIAMMSQYALPQMNWNLVQDDDKEWDCLGIPYLNFKAWMYIVLPKKESSLSELIKGMTKESFDKWTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAH7</accession>
    <name>A0A914YAH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAH7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16437.t1">
        <property type="protein sequence ID" value="PSU_v2.g16437.t1"/>
        <property type="gene ID" value="PSU_v2.g16437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16437.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10373" checksum="088B4BC0CD796826" modified="2023-02-22" version="1">MGQISTAMTITMLVIPLIVNPLTPNNTQDEWAMAFYAVAAIMVVCNILYCFLASGEQQYWAKSEYWRKIDSDKADAECDKNNKFRNDIVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAS6</accession>
    <name>A0A914YAS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15868.t1">
        <property type="protein sequence ID" value="PSU_v2.g15868.t1"/>
        <property type="gene ID" value="PSU_v2.g15868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="143"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15868.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37249" checksum="D8262ACAF350D9D6" modified="2023-02-22" version="1">MGPFYELVTSELLLPVDKALLTELKQKNTKKIQKIDAEILDAEQNGRKSEVCQAFRKKSEYLCQIGDKDAAVSAFHQTFEKTDGRGGRIDLVFNLIRLGFFFLDHKLISANINKAKGLIQYRDWESKNRLRAYEGLYKMATGDFKGAAALFLEAVPIFGSYELMSYEDLVFYTVLSTVYSLDRPELREKVMRCNEIQEQLTGGGEKGDLIPIRQYVDAFYNCTYDQFFIMLAQLESQRLKFDRYLAPHYDLYSLDMRLKAYEQFLIPHTAVRLDMMAKDFGVSIKVLRQELGCLILDRKKLNYSIDDVKQIILKNNPVPTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB10</accession>
    <name>A0A914YB10_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB10"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1468.t1">
        <property type="protein sequence ID" value="PSU_v2.g1468.t1"/>
        <property type="gene ID" value="PSU_v2.g1468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1468.t1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45419" checksum="3A7D603BC07B0FE4" modified="2023-02-22" version="1">MGRTKIERTASQEALHKAELKQKKAESDRKRRAEKTAEQKDEVKQKKRKDIADKRQNLTEVEKANMNETARLRVEAQRATQTEAQKAERNETERLRMEAQRAAQTDAEKANMNEAARLRVEAQRAQLSAVVRAEQNAEQRARTQNRRSNFDEHEARAENATARLRMQLKRNKVTKLCAAGFEVDDNGEAHYGGPLNFICTHCGSKHFESEKISNKGLSFYGCCQHGTIKVEIPDYPEELKKLFDLPEFKRDIRPLNNVHSFGSFNADVVNFGVNRPGPYAFVVQGQVYYQINTALTNESNQPKSHGQLYIVDPEEAVENRIGIFNNLNPDIVKKLSTILSEINAHAKAFKMLYEEIKLQKEIAEEMGVDPLNLSLHFGIKPGQDQRRFNLQASNEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBA2</accession>
    <name>A0A914YBA2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YBA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16560.t1">
        <property type="protein sequence ID" value="PSU_v2.g16560.t1"/>
        <property type="gene ID" value="PSU_v2.g16560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="41"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16560.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21343" checksum="E347864F5123AC2B" modified="2023-02-22" version="1">MHQQQAGQSSTSTTTSTTSTFTSHKRNSKDRRMKLEKIGLYRVGRTLGHGNFAHVRTGYHEIANTKVAIKIVDTQTIDAENIAKINREIQILQRINHPYIVKLYEVIRTDRYWYIITEYVGGGELFEMLTEKGKQPEIEARRLFQQIVSAVAGCHGSGVVHRDIKAENLLLDKDNNAKLIGKFPKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBX3</accession>
    <name>A0A914YBX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16926.t1">
        <property type="protein sequence ID" value="PSU_v2.g16926.t1"/>
        <property type="gene ID" value="PSU_v2.g16926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16926.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15802" checksum="3063DB7361C00FD1" modified="2023-02-22" version="1">MSRNDMNKLFEDVVNLKVVIFGANFQNIGNISRPRFIQKNEISPTPFTTSLPQALLRSDGIHRKSKTYTTCLSEDISESNGIKWTCNPIKFYMDIEIKNSNVYLSFFIIDHQFYPVLSGDFKVWIEDKEHEKVSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBX6</accession>
    <name>A0A914YBX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase MuDR plant domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g16790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16790.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34310" checksum="3C73AC5367EE82C4" modified="2023-02-22" version="1">MEKLRFFYNFCFFGIAQTSKTVEISENAADTLSNSALDINEVQFDNAAATNVPANPSLVTLKKADNFRSRKRKASINDADDDLSSDDDFSSDDDLSSDDDLLEEEEKGVTSDFHLTSDESALGAGLEENEDGCDPPPAKKSRIVYRYKEIKIISSKEELEEYETSLQGFLNFKRTSEGSQSVVKEYECKEVKRGCKYLVNIKIPHESSTSTVYERDCGHDHSNAKVKKMDKNVKKFLSQNSGLSAGVISMKLKESGLSILPTKQINNFLHRERKKKGQNGTLSEYELMEEVQKYPRNDKHPHKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC65</accession>
    <name>A0A914YC65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16880.t1">
        <property type="protein sequence ID" value="PSU_v2.g16880.t1"/>
        <property type="gene ID" value="PSU_v2.g16880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16880.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24381" checksum="362FCC65AAD9DF35" modified="2023-02-22" version="1">MLNRSLGAVSRKSGGSGKSRNSPAYKTMMCNMFSTNGSCSYGTGCQYAHSKEEIRPTISHPKYKTQLCNKFNTPRGCQYGEKCHFRHPDDSEAELRIDSRQNNKTSNGNSGKKKNGPKVVDPQSPASVSSMRDSAPTEISATNGTKKAKNKQGSFIKLSMYHRFENYVGKNRKPGTLKRSNSLNTVGVFTFQRFLAMREVIKTQLVTKKQQINGKPKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC75</accession>
    <name>A0A914YC75_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YC75"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1689.t1">
        <property type="protein sequence ID" value="PSU_v2.g1689.t1"/>
        <property type="gene ID" value="PSU_v2.g1689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000041">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF215">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-17 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="90"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1689.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31312" checksum="905F9010A2CC823D" modified="2023-02-22" version="1">MDNILHVPLEDSDRERDKTIVYRVVDNGDENLPFTDDVANACINLWADKNVRKAYDMRSEYQLNDSAKYFLDSVSRIHEHGYRPSEQDILYSRVATTGVVEVKFKIKDLDFRVFDVGGQRSERRKWIHCFDNVESIIFITAISEYDQVLFEDETTNRMTESMQLFSSICNSSWFLQTAMILFLNKKDLFGEKIQRVNITTCFPDYEGGQNYEEAVAFIKLKFSELNMHPDKKTIYMHETCATDTNQVQLVISSVIDTIIQKNLQKAGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCV3</accession>
    <name>A0A914YCV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18063.t1">
        <property type="protein sequence ID" value="PSU_v2.g18063.t1"/>
        <property type="gene ID" value="PSU_v2.g18063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18063.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33686" checksum="AF23105B75B2EDC4" modified="2023-02-22" version="1">MTFPLLNLPNELLVKIFGLLEFDDFISMKSTCKVAKNVAEKNVKFMPKKEKDSMRIYFGFRRIGNCLTIVETCLDGKKKTLTFGSDENLMLYLSNLKIINRFFIDAYNPSFISHFTIGSLIENVEILNLSNIKIPMSATEILPLFKACKKLNHFCLESGSLINGKLLTLVDQMNYCYSVRCHGESNLEIDNECLQIISSKSTELTPVLQIFVPEIPSSITLTALVEFLRSTIFLQNSSISLSRVIGTRHELISSFFPLIRLLHFEATLYDFEAMISVSEDVYIRLNICNFQAPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCZ6</accession>
    <name>A0A914YCZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCZ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16615.t1">
        <property type="protein sequence ID" value="PSU_v2.g16615.t1"/>
        <property type="gene ID" value="PSU_v2.g16615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16615.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14112" checksum="260A9637207FAB68" modified="2023-02-22" version="1">MATSASFEYYPFLKMLSKMGPQGSSKVYNCVPSTLFTLNMLDQPHKDVINFLMTNTPINVEEICAPEMKAKIRTIVEFLATLRIVEVQNGITNLCPSFRRAYIIRPIRTLSKACRYRTLSKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDB3</accession>
    <name>A0A914YDB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15439.t1">
        <property type="protein sequence ID" value="PSU_v2.g15439.t1"/>
        <property type="gene ID" value="PSU_v2.g15439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15439.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21396" checksum="AFD4B4A6A083333B" modified="2023-02-22" version="1">MPSEIDFDPYEVLGLKLGESIKHVKKAYKDVARKCHPDKAKPEDKEKAEETFHKLKKAYDFLTDQESKEKYDREGAARLVRQKAQEEKKAQSSATRRRFVDELEKTEAAFGVKKSKPAGPKDFKEMTEKELNMFRSMNKEALNQFNAQMNRINADTHAKVTKVPKSTPADYSDLRAAEEDILGDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDP4</accession>
    <name>A0A914YDP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17550.t1">
        <property type="protein sequence ID" value="PSU_v2.g17550.t1"/>
        <property type="gene ID" value="PSU_v2.g17550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17550.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25685" checksum="41613B8C2474BFF7" modified="2023-02-22" version="1">MPFPKQPNIITSKNNSSKKRVTVVLETGLSSPRIFPTRSSSFSASISDIAENNDDKEEDKSESSESIATTTITYSASFEIAPITSPSKKSAKTSEFWERNYLKGQSPRWSRKTISSSAKARSKSSGPSSGYYRRPVPSTAFPIVPLYSRASSSSSIDYNRMDSGRFTSRSSAREERARKRRIKALFRADENDGNNSPGTSQIEDEEEEEVYRGIENSDDEEGEGDDDNDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEG9</accession>
    <name>A0A914YEG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEG9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1866.t1">
        <property type="protein sequence ID" value="PSU_v2.g1866.t1"/>
        <property type="gene ID" value="PSU_v2.g1866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1866.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21207" checksum="B29F69993200DF51" modified="2023-02-22" version="1">MVNVIVNGITLSAQMDDGADLTMMAKVDYTKIGSPALAGPTISANTANGHDLKLLGSFKSMVDLRGKSRLVEFHVADIKSTLLGTNFFKTFGIDLVMDGEVLCNMVVGHSMAPVKKVEELMDKFKPLFEPALGQLADAKDGMDECLSTRRINTIVTAPVTAHEINAALAEDVTATLRDKGKRMSGINFDCFSRYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEJ8</accession>
    <name>A0A914YEJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17878.t1">
        <property type="protein sequence ID" value="PSU_v2.g17878.t1"/>
        <property type="gene ID" value="PSU_v2.g17878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17878.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="50433" checksum="AB3C32A27DA6FD2E" modified="2023-02-22" version="1">MTFFRTDNNNIDSQQGNTDMDEEDDDDVTIIVKTETDDIDDEESKTLGFAENKCDVIILESDTEEEEENVAFFEEEESSEERDENDDDEIIVLDSDSEDDFEESSENIQSLKDEEELKNDENSNFGYIDNDLEDDVILRIKPEINDDDGDCKYEAEEEENKEQIETSAIVDEIKKPDDFPMFQFLKFIKDVNAHKKDKLLKLKGRPDIVKIAASIPELDKHRDFYMSPGFNTNFNNLFKTAARRKNIYLDHVTTIINRYLTDGESVEYFDGFPKAPSRPINMYISEKADGEQNNIQTIARKRKSFSSGEIDRKPYFEKYVNESKEYIKKIEQYLHQERKNLCESHVVHIQNLISKKEKEIEKAALGESEPVPSRKKSKRQIKTAFDYFKDANPNLYSDYETERRNSKLLKKFNRLEDNVKQIYENIAARNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF56</accession>
    <name>A0A914YF56_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YF56"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18915.t1">
        <property type="protein sequence ID" value="PSU_v2.g18915.t1"/>
        <property type="gene ID" value="PSU_v2.g18915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03241">
        <property type="entry name" value="ABC_RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="DNA REPAIR PROTEIN RECN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN RECN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18915.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="18393" checksum="13C2633BDCDB30C5" modified="2023-02-22" version="1">MHALSMPHGQFTIDVKFDEHHLGADGADRIEFRVTTNPGQPMQPIAKVASGGELSRIALAIQVITARKMETPALIFDEVDVGISGPTAAVVGKLLRQLGESTQVMCVTHLPQVAGCGHQHYFVSKETDGAMTETHMQSLDKKARLQELARLLGGSEVTRNTLANAKELLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFG8</accession>
    <name>A0A914YFG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TGF-beta family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFG8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16106.t1">
        <property type="protein sequence ID" value="PSU_v2.g16106.t1"/>
        <property type="gene ID" value="PSU_v2.g16106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF310">
        <property type="entry name" value="PROTEIN 60A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="10">
        <location>
            <begin position="259"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16106.t1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42500" checksum="4E9ABEC8362664A8" modified="2023-02-22" version="1">MTSLYKFLGHTNEINFNPSFRRINPNPKLLTFRYLDKDTGTTDFDFNKILSDSDQFDSIVGFVPENITPNSEISKSIGSNIIEYDFKSDSDDSLSDDSLRLVHAELYFAVENDTIPLESIKVYFSIGEEEFKEISGSQIIRMNNTQLLAVNVTKIVQSWIFFPNSNRKLYVKIDGSSSPDLDLLNSIESFIPDLHCFGVGFFVEMDDDEFPPLFSSPNRIRRDAPVPSENGINNDNDETLEDDDSNDIPVFPSTSSSSSSSKARTFDILAKPRSDSCRVRTLFIDFSSIGWGEFVVAPSGYRANYCDGGCPFPLDMKFNPSNHATVQTLIHLIDKNKTGEALCAPSLMDKPLSFLFIDNNQVKIKKYLDMSVIQCGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK67</accession>
    <name>A0A914YK67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19264.t1">
        <property type="protein sequence ID" value="PSU_v2.g19264.t1"/>
        <property type="gene ID" value="PSU_v2.g19264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035291">
        <property type="entry name" value="DUF5354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31712">
        <property type="entry name" value="DIETARY RESTRICTION OVER EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31712:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17305">
        <property type="entry name" value="DUF5354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19264.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16424" checksum="57A247913557B8F4" modified="2023-02-22" version="1">MYTFMNTLYRSIIVTFIIMAISYQRSLALTCYDNTNPGGEMQTLSNDEWTFCAFIPESSKSKGKVFGIGPASDDVSPYMLAFGDSEPGYQVLTMCTYEQYDFAQILNKQLPKEYLFRCVCNYDKCNQLNTFENYLTNLGGSSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL05</accession>
    <name>A0A914YL05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19558.t1">
        <property type="protein sequence ID" value="PSU_v2.g19558.t1"/>
        <property type="gene ID" value="PSU_v2.g19558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF360">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19558.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15253" checksum="811DC6781334C0AA" modified="2023-02-22" version="1">MRDLFDKSELLQWTEYTMQIVGSQEKNDFGDLLLYLAYSAKTEKLFITVAKAYNLRPMDITGASDPYVRCEQIYQRKRIKLRKTSIKRANLNPVYHECLEFDLALNQIDETNILIQVMDWDRYVLLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLZ7</accession>
    <name>A0A914YLZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20394.t1">
        <property type="protein sequence ID" value="PSU_v2.g20394.t1"/>
        <property type="gene ID" value="PSU_v2.g20394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20394.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15721" checksum="C0DC18E668D0BA61" modified="2023-02-22" version="1">MNSTINCKKLPFELPSGKEGTFNRCFTVPECMPSIIDSSIMKIEYFVFVKFHVNGLWDLYFSYINTNTSSCPKINIPVTISKSLIKPPKLSKSKSVAATISEIPTQLMPHPISDYKISPPPTYEDAVGITYLDKENKIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMZ5</accession>
    <name>A0A914YMZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20966.t1">
        <property type="protein sequence ID" value="PSU_v2.g20966.t1"/>
        <property type="gene ID" value="PSU_v2.g20966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20966.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="12593" checksum="E6DED39343B6017C" modified="2023-02-22" version="1">MDAFAAVAGEGAAPVVAQRHGDLRLHPAGVAAAGGPGLVGPRAAASSPAMAADGAQAAAGRAGLAGQEPFPGHAGPRSAHADDWRAGHERAAAGDPAGSGAARLRGVDPAGPQPSAAAGQRCAGPGPHRSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN51</accession>
    <name>A0A914YN51_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YN51"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2301.t1">
        <property type="protein sequence ID" value="PSU_v2.g2301.t1"/>
        <property type="gene ID" value="PSU_v2.g2301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052665">
        <property type="entry name" value="Neuropeptide-GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224:SF37">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2301.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48996" checksum="097F76A84F489AE2" modified="2023-02-22" version="1">MPERALSPFAMRMSLYVICIGGIILNIAVFCKRKFRTKRQSYTTRVSLQLLCFMAIADTISLASLLLVLCTQYLGIENETTMDMICKIDLFLIHSASAFSIWCWLILSAIRYIALYKPYAHLRLNKEPVLAVIFIAIISILFESWILYDATFVPEFRGCGEKFSEEVEKRFQIAEISWSYFLPLIIITVLDIKVLCCHSIWVTDWTLTKSFDYGINSSNNNSSKSIKRKMTVDECIGVDSSSPKMSLINSNFPPNAIKYTPSYDESPTATSPPISANVVSPGGAGEKERISTKISICSFKKSQTMFSFSSISQGGTAAFKSLKTPLNRQKSKKRQRQMKILRRCLCITLLDLGMNLPNYLFRLYVNLVPAEQLPNFDGYWFAMFQDISQLLYFAQFSLNAFYLVCIIYDTPKPKRSIYQNTNSRPSRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNA3</accession>
    <name>A0A914YNA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21085.t1">
        <property type="protein sequence ID" value="PSU_v2.g21085.t1"/>
        <property type="gene ID" value="PSU_v2.g21085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21085.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10941" checksum="A1B3710753D4F153" modified="2023-02-22" version="1">MNEQSPTPRRSVSMMNFSWEEKRERSLPPSIPENDEKIDDTESQFSTSNNKEKLTQQSPKRKPNVPMTPRECAELDEVSAFKLLTSSEPVQEIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNF8</accession>
    <name>A0A914YNF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase delta subunit OB-fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18869.t1">
        <property type="protein sequence ID" value="PSU_v2.g18869.t1"/>
        <property type="gene ID" value="PSU_v2.g18869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="3">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18869.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21464" checksum="35952DA2CB7CAFF1" modified="2023-02-22" version="1">MSFKKYPIFSGDSVEPVSLGDIRGDKKSLVIGCLIKRMQNRMAVLKDFDKQNKEELEVRLHREDEMETLALETDFLELEDCHKQKVILKGNVDHYKFVTGLVVGIYGTQTENYFNVEKMIMPALPSYIERPILEKDLFVVIASGFNVNNECPSILRELNYFSDIFCSEKYYNNIARMIFAEYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNL7</accession>
    <name>A0A914YNL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNL7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18938.t1">
        <property type="protein sequence ID" value="PSU_v2.g18938.t1"/>
        <property type="gene ID" value="PSU_v2.g18938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18938.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20159" checksum="C955DAB250437940" modified="2023-02-22" version="1">MLVEFIYGKLPWRDVKSKKICQVKEDSFATLFRHGPVELYAVVDHIQTLKYETRPNYDYLREIISTICTSRNFKFSDPYDWEAGGESYETFEQLKNSYSTTSGTTRTTTASPSPQSRSQKVENFEKPKNEESFVEILEQQPSPPAEKFTDFSVKKKPEDDEHFEDAKDDTKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNP1</accession>
    <name>A0A914YNP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNP1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18968.t1">
        <property type="protein sequence ID" value="PSU_v2.g18968.t1"/>
        <property type="gene ID" value="PSU_v2.g18968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF110">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18968.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22330" checksum="FA79A9B3A02288D7" modified="2023-02-22" version="1">MSDMEENRSLTGSPPLTDHPDTATDSSSESRVTPEPNNDDEKSQRELLEISLAKCLGQLGAAAAAASHRTIPIYPHKNREERKRRRVIGNNDNTLDGLVAKRADVDPTAKRYQTETEAIELPDDEIEMKRLETDPDVSTRCCSICGYQGKWVSEMIRHKRVHTNERPFKCKYCNRTSKWKADLIRHVAIILKHLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNZ7</accession>
    <name>A0A914YNZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2115.t1">
        <property type="protein sequence ID" value="PSU_v2.g2115.t1"/>
        <property type="gene ID" value="PSU_v2.g2115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF13">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037709399" evidence="9">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="32"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2115.t1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46444" checksum="63639A3356B81D2A" modified="2023-02-22" version="1">MFLQYFIFLVITISTTFSKTIDNKLTGTPEVKCGPDSIEIKGTTEDDFEGALFVKNWRTSGCFTAYEKLVNTTKNPTFTIPLTELSKCGLELRRHSQTRELEVFTVFVFSFHPSFVTMSDRAFAVHCIFQQQTITVATKFNFISDITTRATFNGVSAMPEPSLTIVNGRLPDEQLTPAKLVKVGDAIMFVWNMTHPSEIYGIQVEDCIAKTLDGRKMKILENGCTTDDIIISSVTYGERNQKAFADAMAFKFPDVEDIWIMCSVRTCIQKREHLLIETGISEEHLCKSEPKCEKQHRLKRQTHDLTAKIDGTDESITILHNKLQVIDVYANENSTMALSLHSQKNDENEVQEENKLKLCMLKSVYAMSAAFLIMLYFSTAVSGGILVYSLRKHSKQTTSHINNNNNQLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPM1</accession>
    <name>A0A914YPM1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPM1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2776.t1">
        <property type="protein sequence ID" value="PSU_v2.g2776.t1"/>
        <property type="gene ID" value="PSU_v2.g2776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037139200" evidence="2">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3 4">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2776.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20354" checksum="500D573C15DE75F4" modified="2023-02-22" version="1">MFLVFVFIGLLSFSYCNDDSSSREAASNYECQNGGILKDGKCECQVGFLGSRCQRTMHCAGHKVKIDGTCVKCDDGYIGLHCDVIQCKNGQRLYGEICNCTKPWSGRVCDQLLTSDVYLYYNRMITQFGPIGVIIIIPMILIRYGCSKLARKRQVKRVERSLEEQNKTDVSATIVANLLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPS3</accession>
    <name>A0A914YPS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19361.t1">
        <property type="protein sequence ID" value="PSU_v2.g19361.t1"/>
        <property type="gene ID" value="PSU_v2.g19361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19361.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8385" checksum="531646C96B844E71" modified="2023-02-22" version="1">MDNNQKVISLLTLLLLLSLQLSFSQTWLQFLLVILLPNLVPKLSSMLHMMISILITSKLSIPVVIVLDGQSKQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQR0</accession>
    <name>A0A914YQR0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQR0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21408.t1">
        <property type="protein sequence ID" value="PSU_v2.g21408.t1"/>
        <property type="gene ID" value="PSU_v2.g21408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21408.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22397" checksum="2836E700D8D4FAEA" modified="2023-02-22" version="1">MARTFLYLISVGIDPERLRFRQHMGNEMAHYAQDCWDAEILTSYGWIECVGHADRSCYDLEQHAKATNVKLVATKPIPKPKTVTLTVPVPNMGVIGKQFKADGKLIKTLLEKLDVSEVKKLSDAIASKKSYEVRGNDGRTFSLTSDMVTVKEEQKTLHVEEFVPSVIEPSFGIGRILYAVLEHSFKQRDNDEQRTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS58</accession>
    <name>A0A914YS58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g285.t1">
        <property type="protein sequence ID" value="PSU_v2.g285.t1"/>
        <property type="gene ID" value="PSU_v2.g285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g285.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12840" checksum="B771FFF8C3A7B2A4" modified="2023-02-22" version="1">MNFRSNIAVIQMMERLSQFSDCSVKPLPTYTKAMDSSFPFNPSPEFVVCTPPPPYTVIEMPVDSTALMPECLPPPNYDNIIITTDNNETDNELPVYSASLPRTLDSNSISNFNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSI0</accession>
    <name>A0A914YSI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSI0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g261.t1">
        <property type="protein sequence ID" value="PSU_v2.g261.t1"/>
        <property type="gene ID" value="PSU_v2.g261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g261.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8446" checksum="7DF9A37FB56E8F29" modified="2023-02-22" version="1">MALPPKCVYDDDWDDDEVFQKLSVDSESFIAPGKHTVVEPMPTLNPGCTDLVVYDPLSVKTEESSVPQTSEEDVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT45</accession>
    <name>A0A914YT45_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SLC12A transporter C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YT45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3169.t1">
        <property type="protein sequence ID" value="PSU_v2.g3169.t1"/>
        <property type="gene ID" value="PSU_v2.g3169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF73">
        <property type="entry name" value="KAZACHOC, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="6">
        <location>
            <begin position="95"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3169.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18667" checksum="24440AC3CD0C56AB" modified="2023-02-22" version="1">MEERNKLLREMQLNKRDTVDIQAQMDEVVRERKLSKISEDEVKQVQAKQNKDHGNSKVRFSENSVEISQPSLPESNEVPEIMPSFNLKPRHYNVRKMHTAVKLNELMKTRSDEAQLIIVNLPGPPEDGSDIYYMEFIDVLTEGLNRVLLVRGTGAEVITIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT47</accession>
    <name>A0A914YT47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT47"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3861.t1">
        <property type="protein sequence ID" value="PSU_v2.g3861.t1"/>
        <property type="gene ID" value="PSU_v2.g3861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3861.t1"/>
        </source>
    </evidence>
    <sequence length="726" mass="80347" checksum="5C9597BE6AD58A5E" modified="2023-02-22" version="1">MKINSAILKKNSRSTTNLASDPSTSSLLSQRNSDDDTLNSPRKAKQRRSNSVVRMAFKSFKKSFTNLTSDAFMSTPDPPGLANKKIPKPIYHQQTPITQSVSMDPSTTTSSDDTLSDFARRKHPEYSGVNIQEIRKVMSPKDSKKRPPIPNFDNRSSSTDEKKENEQEDENAAKKSIILRKRSSSGSKKPMGVSNAANIHRAATQMMHRRDQPVKIDRSRRSTAPVKTSIKRMQPVSRTSGLTLSQKVRPFHRRRSSSRRSRSNTSTSSSNSQSPNSTQEHLEHKGTDARRRRRMKKRDNSESLTNVYSNSTVITPMSPLKVQNSISPTLTATPNSVKKEPTSDLPLTSDVSSPELQRAVPALISPCGTTPKASMVSLITKKKATPPLSVDVNVSPHLEPLPLITPSPDSGCSLASSSKQLQTDSDHMFVVPELPKRFIRPAQVDIKPSGTSIYFHTESSRAKQKSPVHKSPLPHTSARRSSSATSSRPSSKSPSRRLRPQIIPASPSDHKIFDFNVHDEVFDGKERHIILNSTSNDDCNFPEVGRPSIAQIQGTGVVSRRIQQYKKLSNNSSKFPTTRGISGNDPTFAKPMGKPASHSLLWKKTNVNDTIPEQPTKLSRFAATKTVEQKTPIKKTIVKKKEDLTRRKALMDAMSKLSLRSPMKNLKAKSQNFGSSRAKSVTSMYSAHRNVLDSVRPSVSATSQISSSRIKKIECGTTISRYPKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT58</accession>
    <name>A0A914YT58_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3 7">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3 7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YT58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2848.t1">
        <property type="protein sequence ID" value="PSU_v2.g2848.t1"/>
        <property type="gene ID" value="PSU_v2.g2848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000021">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2848.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="39298" checksum="FE161DA2A975D068" modified="2023-02-22" version="1">MASYSQYLSKEKEDELRSIAQAIVASGKGILAADESTGSMEKRLQPLGLENTEENRRVYRQILFTGNDELSNYISGVIMFEETFYQKTDDGTPFVELLKKKNIIPGIKLDKGVVPIAGTLGEATTQGLDGLSARCAQFKKDGAQFAKWRCVHKISSHTPSHVALLEVANVLARYASICQQNGLVPIVEPEVLPDGEHDLARAQKVTEVVLAYTYKALSDHHVFLEGTLLKPNMVTPGQQHSGSKYSHEDIARATVTALQRTVPAAVPGVVFLSGGQSEEDATKNLNAINAFQGKKPWALTFSYGRALQASCLSTWGGKPENIDAAKEILLKRARANGAAATGKYSGDSADGAAGQSLYVANHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVE5</accession>
    <name>A0A914YVE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4561.t1">
        <property type="protein sequence ID" value="PSU_v2.g4561.t1"/>
        <property type="gene ID" value="PSU_v2.g4561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4561.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15741" checksum="C3E364E37411B360" modified="2023-02-22" version="1">MQCEDHDVYNGIVAGIDTAGSAIIVFSLQYIRFDWEKNGEIIAVITTFCFAWLYFAMAIIENIFIQYLLYLSVVFCYVALITVAMTVITSQLDPGSFGLVFGFNTVVATMLQSIITFSVVDSRGLNLTVRGHVSIRRLFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVI0</accession>
    <name>A0A914YVI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TonB-dependent copper receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVI0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3668.t1">
        <property type="protein sequence ID" value="PSU_v2.g3668.t1"/>
        <property type="gene ID" value="PSU_v2.g3668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044718">
        <property type="term" value="P:siderophore transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01347">
        <property type="entry name" value="ligand_gated_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="entry name" value="TonB-dependent receptor, beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="entry name" value="TonB-dependent receptor, plug domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="Beta-barrel_TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="Beta-barrel_TonB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010100">
        <property type="entry name" value="TonB-dep_Cu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="TonB-dep_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01778">
        <property type="entry name" value="TonB-copper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069:SF49">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="TONB-DEPENDENT OUTER MEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec_b-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52016">
        <property type="entry name" value="TONB_DEPENDENT_REC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0798">TonB box</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037019601" evidence="8">
        <location>
            <begin position="30"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="TonB-dependent receptor plug" evidence="10">
        <location>
            <begin position="60"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="TonB-dependent receptor-like beta-barrel" evidence="9">
        <location>
            <begin position="207"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3668.t1"/>
        </source>
    </evidence>
    <sequence length="556" mass="60615" checksum="DF84C88C3CFFD878" modified="2023-02-22" version="1">MKMTSRPAGACARLPVALGLAVAASVAHAAPAEEARTLDTLVVTAAAPSSPLHWVTDPRLPRQPVPASDGADYLKTVPGFSAIRNGGTNGDPVLRGMFGSRLNILSNDGNLIGACPSRMDNPLSYIAPESFDRLTIIKGPQSVRWGAGASAGTVRFERDTPRFEEPGVRADASALVGSRNRNDQVLDLTLGNPTGYVRASGNRSEADDYKDGHGDVVPSKWRKWNGDVAIGWTPDADTLLEISAGAGDAIARYAGRGMDGAAFERTSYAARFEKRNLPGAWDTVQANVYYNEADHVMDNYTLRTPNPNSMMPMPMASNVDRRTQGGRVSSEWRWQDVQLVAGVDGEDSRHRGRMGMGRGTYRQAAWETDANFRRYGVFTELTFGAGTDQRWISGLRLDRASVRDERQSIRGMMGNMPNPSAGQRRKEWLGSGFLRYEQDLADGLTWYAGLGHSERMPDYWELFSPDHGPAGAVNAFAGIQPERTTQLDVGLQYKGPRVQAWVSAYAGQIQDYILFTYHGSGMMGMSQASNVDARIAGAEAGLEVSVAEQCRRWKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW22</accession>
    <name>A0A914YW22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YW22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2282.t1">
        <property type="protein sequence ID" value="PSU_v2.g2282.t1"/>
        <property type="gene ID" value="PSU_v2.g2282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="942"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="943"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2282.t1"/>
        </source>
    </evidence>
    <sequence length="1115" mass="122842" checksum="81F5F9F73F6A28F9" modified="2023-02-22" version="1">MSLAAASSGAPEAKKFRFSLPTQVVVNEFDFEKNQRNGTSLNNNNNNNVGDDVSEDVDIDVDGSQNDEEATGYDNHSENGLDLTSTSKLSPSIINSNINVKLEYQSPSPPKIPAMTSNNNNNNKFSGMPGGGAPFDFPLAMLLQQANSLAMKNFSNVSNLSKEDLKATILAQSRGPAPAIPPTPPAPIPGALAVAASPAAQLFSEDDWSWHRNPAAAIRSGGTNKQTPVWKYFVYNKAENLSRCIIGDCTYMLKGPHTSTLACHLKKHPVEYAEFQKLKLKFQQEYTRERNAGQLTTNLSRTSQSSSAESSAIHTPLSGTPTPSVNHINGANNGMLNTAAFKLTNQIKPESTNSSINGGIFGNSNAKSNPGNKAPGKTASMTDILNLLNARASANASPKRQQKPATPQPVPQNHDLPLAPQGQQPQQQPTMMPFSAAALMAAQANNPFIFNLLKQNPNFMNLNNNNNNVQTLNNNNTSHSNYTNNNISLHNNNCVSPNKVIDLQKKWQRQDRKQREMEIKLGLAIAAAQLPTALIKNPFFRDFVETAQPKFTMPFEVNHIDELINTQYARTIIAVKMQLAAAPKISIIIDVLKLRGNDQENVENFENDDCSRINQLPKTQSIRLCVSAAYYSSSSQSMEVVLLGIRKPSMDMSINDAIKNVVEQLLNEFDLEWDRVSRIVASGLNDLGANLNVLPRMLAPYNRKLTLSLIDIFDTDEMIIELKRDFYTMIYKFMGRPEAMAQLCKQVGHNVTLPIGEPFFILAENLLKVKSAFLTVCCQQPLDNPISIFSESQWQQLEHAIKLLALFRVHMSVIQDGRYATIDRVVPSLMQLKVSLERDFSALGTLPHRLLEDLHQRAQYILDSTAENFDGSFIQATALNPQLAMLLDDSQMTFAKSSIEKLLSERMRQSDESLTRKNGVKSNNGGVDALLAAVVERKNSNVSSSAAISPPLSSPSSTTSDMNATSSASTASTLYPDLIQAANQRRKQFQDRISNGKNLFAEAMVQSYFDDLMHTVTSSPSSTDAGMPPQAATLPPLQFWQLSSVKCPQLSDIAIELLTVPSCTVSLEKIFNYEGVSQAAHPSLEHQLLKSMENPTRMERDAILRFNRAFIPKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW84</accession>
    <name>A0A914YW84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RelA/SpoT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g234.t1">
        <property type="protein sequence ID" value="PSU_v2.g234.t1"/>
        <property type="gene ID" value="PSU_v2.g234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773">
        <property type="entry name" value="GTP PYROPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773:SF1">
        <property type="entry name" value="RELA_SPOT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g234.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17205" checksum="619721B651D41F48" modified="2023-02-22" version="1">MSDSTLNESQKRYSEAKVEIQVASVLMHAWSEVEHDLVYKPLQGALSEEEYAILDELNGLVLSGEIALERLQRAGELRASTRGREFTNHYDLAASLLDLARIHLSVGDVTQAAMGRVDVLFELNEGGQSKHPGSTRNLRPGAAQRLREAAALRADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWH0</accession>
    <name>A0A914YWH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4455.t1">
        <property type="protein sequence ID" value="PSU_v2.g4455.t1"/>
        <property type="gene ID" value="PSU_v2.g4455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037471905" evidence="1">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4455.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13608" checksum="4342E948D380CCC0" modified="2023-02-22" version="1">MKILHFLIFLTFIQIIFGRRGAASIKKSTRINFQEDLNAETDSLIYKPKTYHYYQLQNQQPIYPTQQIYGQPYYQPVYYQQQQPSYYYPQSYYPGGGGFGFNFCLTCFSLGFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWZ5</accession>
    <name>A0A914YWZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4487.t1">
        <property type="protein sequence ID" value="PSU_v2.g4487.t1"/>
        <property type="gene ID" value="PSU_v2.g4487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13714">
        <property type="entry name" value="PBP2_iGluR_Kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037379545" evidence="19">
        <location>
            <begin position="26"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="365"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="375"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="670"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4487.t1"/>
        </source>
    </evidence>
    <sequence length="782" mass="89174" checksum="1A4E8C60F692106B" modified="2023-02-22" version="1">MINKTLITVFNVHLILLALCCYGSSKPYSTKIGTILFENYHSHFRAIISATRSFLDLHLSLNKITIDDSHVIFLKTGNIHDVVKAVNHLKSENVSLIIGPPENDFGDFVQLFCTEQRILYLSYYFDPQGGISPYIYRLFPKIDDETDNINKFIESGIEMRNICNIEECWRYTNKAILELSAKHSYRFLEASLMLGLINSQNWFYLFSLDNTEHGMESFSHNTMRLSVAGQFDEHMLNNNGTYKPLIKAYKQKLEKDRINKTDITDLVRFHDALLSIPIILPKISQKLSLQKKVIFGLTGKIIFDEQRMRADAAFHVLEMGVDGNQINTGLWYTNSKQLERVLSMTDKTLANTHESMMEETKTQRLLRVVSIEEKPYVMRKTLPNGRIIYEGFCIDLLNRLAHDLNFEYKLTIVPDGKYGEPINGTKDWDGLIGEILKGEATAAVAPITVTAGRLEVVDFTDPFLQLGISMLMKIPDDDNKASSSFLSFLLPLSPSVWMYWAFITVFSVLAVTTIAILSPHESAGQFNATNSIWYLICILLRAGSGYNCRSVSNRIVSAAWWAFTLILIAQYTANFAAVLTIDRKSLPFNSFEELGNQTEYEFGTIQGGSTMHFFMYSRLDTFRRIWLRMQNMSKSVFVYGNQQGVQKVLAEKYVFLMESASLEYQLTLHCNLTKVGNVVLGSNGYSIALPKGSKWRERLSRQILDYNEKGIMMMLKRTWWKKTPQIEECEEQAVETRKSLGMEKVSGIFGLLAIGLFASFVVVIAERMVTTNVSKDKQFVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX32</accession>
    <name>A0A914YX32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YX32"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4666.t1">
        <property type="protein sequence ID" value="PSU_v2.g4666.t1"/>
        <property type="gene ID" value="PSU_v2.g4666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608:SF7">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4666.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14023" checksum="105D7B50ECDE66E1" modified="2023-02-22" version="1">MCHKKQDLLYSRIQYSPTSNGIFVCAIQWIFKLIEEFRVKKKDIRYSVRISALHFSQKSDKVIDLLSDFANEDNSENEVKCTEDPALGILIENRSEIRVETVDQALYYLDRVHDHRASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXB8</accession>
    <name>A0A914YXB8_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5151.t1">
        <property type="protein sequence ID" value="PSU_v2.g5151.t1"/>
        <property type="gene ID" value="PSU_v2.g5151"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5151.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21030" checksum="C377863073F072CD" modified="2023-02-22" version="1">MTLEGGSFTGLTFASPEDLAKFSAINISESIQKNFAPESIVGPEFEGIQEDLISYFAYQNVPAKPDANFYIKRYAEFWSDFLINQEVFNETDAKVERGWPIYFYLWNHMSAPVQATLPAAKGAWHTTELSYTFDEKTFAEDVHGEAEHKIQNYFAEIFAQFAYTGLVLIRDVHRQSAMRVRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYD8</accession>
    <name>A0A914YYD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYST zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5513.t1">
        <property type="protein sequence ID" value="PSU_v2.g5513.t1"/>
        <property type="gene ID" value="PSU_v2.g5513"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
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    </dbReference>
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    <feature type="domain" description="MYST zinc finger" evidence="2">
        <location>
            <begin position="427"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5513.t1"/>
        </source>
    </evidence>
    <sequence length="474" mass="55519" checksum="81AAD0F1801E0133" modified="2023-02-22" version="1">MKFRQPGSLPKGYKDGKASSSDEGNDAEDGDDDDIECIEGVNYPARIMPDPRYYYKGFYFRECSNEKAPNDVGPIELIESLKSMEEVNRYNPDFKEFEVDSESEYELEPDPDPSEFDSWHDYLSNTNKKADEKAPPKKYIKLIDGMTRPQRREHRQFALEFKDLLEALEENHMAHCEKGIKKFSQPFIPPEGFRGRTSGQILEQAQNRMNEYLRKNAFKELGLKDPADIKHEPRIQQRFSEMDLKPLVNMNGMNWRDLLPRKPPKDGEEDVSSESSATTDSDDPLLKDPKPLEWDAAGKGTEKRPPEWDRYRSTNERILYRRYIRRACRTILKSNKRKKKIHKLLQIGSYAPKRPIPVPPTRIPPAIVDDEELMEIPNYMSAREMIYGADPEHKSILIKFFNDLNRRDIKRIKEYEKAAAEGPVPRYIYFGKYQMKTLYTSPLPFHLRIKDEIFLCDQCLGGWIDRDTYERHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYF7</accession>
    <name>A0A914YYF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYF7"/>
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        <property type="protein sequence ID" value="PSU_v2.g4988.t1"/>
        <property type="gene ID" value="PSU_v2.g4988"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4988.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24256" checksum="C2BFD83B7D22F3CC" modified="2023-02-22" version="1">MEVNGKKLEEEEDEVVAEMDCYHVPLNRQNYSAATLHFLTEQPSKMEECIARMKPLVKHLEIDYENGCDRNDGVVNNDELVATFAGKGTSETEVLNHAICFIEQGKAYFVEVDDTFKMRRKLNASTVVDASEEAGSSAMKRNTSPVRVKFARAETDAQRKRREQSSYFKHQQAEQEAWKPVSVIHQEPKFALSIAEDAEVQPNGTGQIKNEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYW7</accession>
    <name>A0A914YYW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYW7"/>
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        <property type="protein sequence ID" value="PSU_v2.g5305.t1"/>
        <property type="gene ID" value="PSU_v2.g5305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5305.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18074" checksum="AB8120534330C525" modified="2023-02-22" version="1">MCEMSDGILVSITSVEKLEFLRNKVVKNIFGENSEFTIGLHRSPLATTKNNNKWFWFGYNNTVFPLGDFKKWEDGKVPSPSASCGFATRETSDNAMAFAAGGCDYDDARPYLCQTKACDSNHFCDLESGVKAATAHSKLQTQIKQRSFRRINKKMYFKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ08</accession>
    <name>A0A914YZ08_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">KCTD8/12/16 H1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZ08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g327.t1">
        <property type="protein sequence ID" value="PSU_v2.g327.t1"/>
        <property type="gene ID" value="PSU_v2.g327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22204">
        <property type="entry name" value="H1_KCTD12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057093">
        <property type="entry name" value="H1_KCTD8_12_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23110">
        <property type="entry name" value="H1_KCTD8_12_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KCTD8/12/16 H1" evidence="7">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g327.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16901" checksum="60C72EC216710264" modified="2023-02-22" version="1">MANEDFNTWISGTFAFGRDGQADVKFRKLHRILVCGKATLCREVFGDTLNESRDPGGEGAERYTSRLYLKHQCFEKACDTLAEKGFKMIASCSSGANGLAPTPHPMLTAQMSNTQQDFMNQRNSGDLEEQRWAHYTEYVFYREPQILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZI2</accession>
    <name>A0A914YZI2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">transketolase</fullName>
            <ecNumber evidence="9">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5352.t1">
        <property type="protein sequence ID" value="PSU_v2.g5352.t1"/>
        <property type="gene ID" value="PSU_v2.g5352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000129">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051424">
        <property type="entry name" value="Transketolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004559">
        <property type="entry name" value="PRK05899.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195:SF1">
        <property type="entry name" value="FI06132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="315"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5352.t1"/>
        </source>
    </evidence>
    <sequence length="626" mass="67183" checksum="A26700471B57BB9F" modified="2023-02-22" version="1">MATDQVSQIGDAANRMRISAIDMTCASKSGHPSSSASAAEIVATLFFGEMRYSVAEPKHPGADRFILSKGHACPILYAAWEEAGLLTREQTLTLRKIDSDIEGHPTPRLNFIDVATGSLGQGLGYAAGMAYVGKYVDKASYRVYTLLGDGESSEGAVWEAAAFSSHYKLDNLVAIVDVNRLGQSEAAPLGHNVEIFADRFRAFGFHSIVVDGHDVSALLKAFAEAKTVKDKPTAIICKTFKGKGIKDVEDQDNWHGKPMVADSVKEIESVIRDRIKGDKPKWNIPSVVTDVKESKLDLGNIKMSSPPSYKLGDKIATRQAYGTALTKLADTTKQILAFDADTKNSTFSIEVMKKHPEQFVECFIAEQNMVSAAIGAGCRDRTIPFCSTFAAFFTRAADQIRMGAISFANVKLCGSHAGISIGEDGPSQMALEDLALFRSVPNSVVFYPSDGTSAERAVELAANIRGIVFIRTGRPALPVLYEPNEHFQVGKAKVLKNTLDGKGKGVVLIGCGVTLYEALKAHDELNSAGIKSAVIDLFTVKPIDTNTILETARAVGSNPQIITIEDHYQAGGIGEAVASAVSSSNDNIRVHSICVKDIPRSGPPDALLDMFGISAKHIIAKAKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZP9</accession>
    <name>A0A914YZP9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5100.t1">
        <property type="protein sequence ID" value="PSU_v2.g5100.t1"/>
        <property type="gene ID" value="PSU_v2.g5100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5100.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18370" checksum="29C1288C4DA4FA04" modified="2023-02-22" version="1">MHSRRIMHRDIKPANVFITKQGTAKLGDLGLGRFFSSQTYNAHSVVGTPYYMSPERMNGDGYNFKSDIWSIGCLLYEMAALQSPFFGEKMNLFALIKKIEKCEYPPIPSDIYSQQMRFLISNCICNDANRRMDANQVTTVSEKMHQHFLQQRSQSAAAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0W9</accession>
    <name>A0A914Z0W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0W9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5532.t1">
        <property type="protein sequence ID" value="PSU_v2.g5532.t1"/>
        <property type="gene ID" value="PSU_v2.g5532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037574791" evidence="1">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5532.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="10493" checksum="B6C80BC304A18810" modified="2023-02-22" version="1">MTSSSKFVIIFATFAFSAAIIEAASKNQDDSEVAQNPKFNLPPRIGGIPALGSGVVAPPLIPKLPGNLGINGNRWGASLLPPLENVLGGLISGIPLIPVRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1B0</accession>
    <name>A0A914Z1B0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-alpha-acetyltransferase 20</fullName>
            <ecNumber evidence="5">2.3.1.254</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionine N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">N-acetyltransferase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">N-terminal acetyltransferase B complex catalytic subunit NAA20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N-terminal acetyltransferase B complex catalytic subunit NAT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">NatB catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-terminal L-methionyl-L-asparaginyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50484"/>
            <dbReference type="Rhea" id="RHEA-COMP:12694"/>
            <dbReference type="Rhea" id="RHEA-COMP:12695"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133356"/>
            <dbReference type="ChEBI" id="CHEBI:133358"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-aspartyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50480"/>
            <dbReference type="Rhea" id="RHEA-COMP:12692"/>
            <dbReference type="Rhea" id="RHEA-COMP:12693"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133045"/>
            <dbReference type="ChEBI" id="CHEBI:133063"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-terminal L-methionyl-L-glutaminyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50492"/>
            <dbReference type="Rhea" id="RHEA-COMP:12698"/>
            <dbReference type="Rhea" id="RHEA-COMP:12699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133361"/>
            <dbReference type="ChEBI" id="CHEBI:133362"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-terminal L-methionyl-L-glutamyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50488"/>
            <dbReference type="Rhea" id="RHEA-COMP:12696"/>
            <dbReference type="Rhea" id="RHEA-COMP:12697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133359"/>
            <dbReference type="ChEBI" id="CHEBI:133360"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.254" evidence="5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4057.t1">
        <property type="protein sequence ID" value="PSU_v2.g4057.t1"/>
        <property type="gene ID" value="PSU_v2.g4057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4057.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28759" checksum="7E53F5673B6297CA" modified="2023-02-22" version="1">MFAISNFDMNDLYHINTINLDPYTETYGLHFYIQYMGGRLPYVFYKACDEHGRMAGYLMGKLEGEGEQYHGHITALTVGVDFRRQGVAKLLMAKFEEICISXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCYFIDLFVRISNKVAIGMYSAMGYVVYQQIIEYYSGENSEDAYDMHKALPVDKERKSMIPKSRPVTVAEAFGEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z270</accession>
    <name>A0A914Z270_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GH18 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z270"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4350.t1">
        <property type="protein sequence ID" value="PSU_v2.g4350.t1"/>
        <property type="gene ID" value="PSU_v2.g4350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000008">
        <property type="entry name" value="Chitinase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF400">
        <property type="entry name" value="ENDOCHITINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036917820" evidence="5">
        <location>
            <begin position="20"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4350.t1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41583" checksum="95F76E6BD96E688D" modified="2023-02-22" version="1">MYQKFLIFLTICFLQTVTAEYVRGCYFSDWAHYRPDKGRYEPEMYIPGTCTHIFFAFAKVNDDYTAAAYDDEDTSNGPNGGYYKRVNALKNQQPGLKTILSFGGWSAGTETFKKLAANEGHRKTFVKSAMQFINRYGFDGIDIDWEYPKAGDYDNYVTLLKEIKAADTSKLLTAAVTADAETVDEGYNVGEMAKHLDYVNVMTYDFHGDWEDQTGETSPLFSSDNYNTAFAMNYWAQKGMPKGKLLVGIATYGYGWKLNDPNNNGMNAPGKPAPPLPLTQTNGQGAYFEICNIGGTRHWDAAQKMPYRVSGDLWYGYDDQSSVRSKMGWLKRNGFGGAFTWALDMDDFNGQCPEKQKYILHNAINEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2M5</accession>
    <name>A0A914Z2M5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2M5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6141.t1">
        <property type="protein sequence ID" value="PSU_v2.g6141.t1"/>
        <property type="gene ID" value="PSU_v2.g6141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6141.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17839" checksum="25CE6B04E2662E44" modified="2023-02-22" version="1">MAEAASMEGLKQTESTIYGRIQYPERLQKDQQLVRVYEIGPGGIRRHLIDLKNTWVARKGDVSQLNFIDPNALPPALTSQLTFEFIFAKSEDFNTPFFTQHYYQEQILEDMKIQPFTVIGKVAAHSLEGEKLNYSLVSQNEYENFVINTKTGKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z311</accession>
    <name>A0A914Z311_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wiskott-Aldrich syndrome protein family member</fullName>
            <shortName evidence="2">WASP family protein member</shortName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds actin and the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z311"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4641.t1">
        <property type="protein sequence ID" value="PSU_v2.g4641.t1"/>
        <property type="gene ID" value="PSU_v2.g4641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF1">
        <property type="entry name" value="WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="5">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4641.t1"/>
        </source>
    </evidence>
    <sequence length="506" mass="55746" checksum="7590B33A9FFB7A96" modified="2023-02-22" version="1">MPLAARSVTPVDIAQGRLPPGVKGDVLECVANGTMANLMRQMSSLGLHAVQIFGDIHKEVSAQDQRIERIHDRLSRLQENLANQQDFPQPPFSSSFEMEGRRKAFKSAMVIDQHTLDRSTLPPAMLELYNKCEDPPNLDLLNPYRDDSKSALKLYTNPEYFFDLWKEEMLKEDPAVETRRMAKSARSPDRDGSPTKKRKQRTSTSATRNHQAPIQSNVVLGHYQQQQRMQQQQNEEFMHFPSEYQAPELLRSNNISYGNEMPPPPGMSMPTQPTRIAPGRPTQQQQQQHSRDMITNFQGLNLAQSNDLGLIDEDDDELPPPPPPLSDHTSLLPNLNSPSAYSSTSTMPMMTAISGSPMKLIEAPAATPPSNGNDILPPPPTSLSSTVMVGSSAPPPPPPPPPPPLSSVTLMTSSTLIQATSFGNSSTTATDTAGKEGSGGNVIRGNLLAEIQAGMKLKKIQIQKEKEEEAAAVEKNDVAAILRQRMKKVTTSISDDEDDDDDEEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3C7</accession>
    <name>A0A914Z3C7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3C7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6865.t1">
        <property type="protein sequence ID" value="PSU_v2.g6865.t1"/>
        <property type="gene ID" value="PSU_v2.g6865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6865.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28752" checksum="BA0FCE36D068DA93" modified="2023-02-22" version="1">MSFATFSDSYIRQIFSFRESLIYYISLESVESLKKLLLTCKYFYLKYRIIPCDVSTKQWGFHENKGEGLIAQNDHKVHPKNVWLCGGKYYLNPPKISELVTKIYRSDIAEMCSKKLKTIFIHDVAILYPDKSMVPVEIILEALPYVDDFHFLVWDPYVEKSCGFTTESAQKLSKIERFVKFVEFRIYDVPANFHLPSFCQFVKKHVSPDGIIRVHFQKETENAILTEFKNALNSLVRVLEIEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3G1</accession>
    <name>A0A914Z3G1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polymerase nucleotidyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3G1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6898.t1">
        <property type="protein sequence ID" value="PSU_v2.g6898.t1"/>
        <property type="gene ID" value="PSU_v2.g6898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6898.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41603" checksum="D6116534DCD47457" modified="2023-02-22" version="1">MSENNLQRFNDAARSSLAAGETVHQLIIRLLQHVGDCLSNLPPPRNIDLPEQFDLRPDNDEATPQTSIYDFVKENVTLNEGRKRQMDTWFQKFIDCCNEQSIEAQIFKHGSVMQGTAVVGSDLDISIRFEEGTQKGLADVLEMLKRKKDVLGLNGFIGIVGKACPTIKCSTTSAINIDITDGGVRQLALCCGHFIREVLRQRTDAVVFIKILKQVFMKSGNYGGSNQCPGGVAYSLLVFRAMQQLGVLPAFQRFDHGDFGVLNEMFDDYWNENAVFASTDYDITDEALTIRFSEILVWLIDTNLSIIFSLTDLEMQNPTDGIVIFSPPNNYQNVGSLVSPQTRLLWIIPELKRLLKKWKENPLECLESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5M4</accession>
    <name>A0A914Z5M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Midasin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5M4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5557.t1">
        <property type="protein sequence ID" value="PSU_v2.g5557.t1"/>
        <property type="gene ID" value="PSU_v2.g5557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001384">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="3">
        <location>
            <begin position="264"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Midasin AAA lid" evidence="4">
        <location>
            <begin position="416"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5557.t1"/>
        </source>
    </evidence>
    <sequence length="625" mass="70078" checksum="53CB394AD51E283C" modified="2023-02-22" version="1">MKNGSKLLIDEISLASDSVLERLNPLLESSRTVLLTDAGADAEVVVAHSDFQVVATMNPGTDHGKKELSKALRNRFTEIWCSCDHPVEDVKKIIAGRMSILGYNVDAELGHVIDGIVEFFITFTEKFGNTFRIVFSIRDIIAAADLFLACKNVAEFSTHDAFINSLTGVVVDSIGVLPARTTYNAAKLKKKCHKMILSIAQKHQLLPVVEQEIAEKQNSLFFGNFPIELGKLPTETVKQYSFSTPTTEQNALRVARALLLEKPIMLEGSPGAGKSSLIVALAKVTGHSLVRLNLSDQTDLSDLFGHDVPISKPDGTISFQWQDGPILKAIKEGSWILLDEMNLASQSVLEGLNSCFDFRQELFIAELNKKFIINSDQCRFFACQNPQTQGGNRRALPKSFLNRFTSIYIEPFIAQDFSLILNQELPDSRLIVEKMIRFNREMQTLVKKECPGIEFEFNMRDLLRWAQFIHEFHDISVGAEILYINRLPYAPIQQDAKQCFGKIFGTDLLTQNSTIFYDDTAGICFGQKKYNISVQNMPSLPLSNLLLLSSQSTLLQQLCICIKLNWIVLLNGPRLNGKSSVIETLCLLSQSKLKRMRLNKETDASELLGSYEQVKNYCNFLNLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6R0</accession>
    <name>A0A914Z6R0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Piezo non-specific cation channel R-Ras-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g8373.t1">
        <property type="protein sequence ID" value="PSU_v2.g8373.t1"/>
        <property type="gene ID" value="PSU_v2.g8373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1208"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="12">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="13">
        <location>
            <begin position="486"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="14">
        <location>
            <begin position="680"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="11">
        <location>
            <begin position="984"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8373.t1"/>
        </source>
    </evidence>
    <sequence length="1297" mass="148251" checksum="80338C66019B5EC3" modified="2023-02-22" version="1">MYGHWITLVMVLVAGLGGTSLFALGYLVLAFWMLWQGNNLYTMKDYRKTLSRWNFLLFYTIVVMFFKISLQVVGCVFLSPLNSGAGCVVRQLLSIICVDEQSCKALATLNTKSDNCIVDVKETRIGFDTMALCFLVFQLRILHSWYFQHCMIDFRCEIIQASRGALLINQLIEKEMKEQNVQQQAKFDEIRSRTAAIRKQYEEQQLKGAQSTFQAQTYGQDSVQQPRPLSMIVVDCDDPFPMYDPRRTTADMGVPAKRAGDYYMFNYEPDSDELVAPVESFVPEVTPGAGDFDKLDPAQLLHTAISKDMDLQGTLNAVETAEKIKDEELRMIRAVAASDEKNRDLVVAVLEPVEGHSSQQVQPTIQEPTNVEENDTVTNAVRFGGKIFRSFLDWLSAFLNRRSREHRYVAFVLHKEKTRLMNEMNHELYDEEASLKEVRHQWESRSLHMVSSESDVSRLEEEAHVKWEQKSFFARLLLAVANCITAHTDVISFVIACIVHAKCAGLITLPLPMLVFFWGTLASPRPSKNFWITLISYTEFEIIVKFIFQFGFFPWNSNAEEAASAREYFKPQYVFGVQRVDYFAFWDVALLIALFFHRYMLRRLGLWKDANIMDTFIEASDVNRQATSTTEVDISDIEARELQSTTQGAVANVTTLPDEQRGVISSFIFKLFHPKFRYIRDLYPLMFFLDVFCFFIVVFGFSAFGDGGSGDVLSDLSSNRVPLTFVIMLIVISLMIVVDRGLYLRKAVLAKLIYQLVTVLFLHAYLMFILPAITHKSAYENSVAKFLYVVKCIYFVISAWQIRNGYPQLCIGNLLTHSYGLVNMVLFKIFMLIPFLFELRTAIDWTWTDTSMPILDFFSMENFYSTIYNLKCARTFETSFPAPRGVPKGIIVKYSIGVPLILALILIIWFPLLAFALLNKIGTELPPERVQFSVSFEGYPRVFTMEAQGNEIQPINKMMKEQLRSIISNKNNNVSVSDDSAALLAKSRRAVSYIEEYSSKEIHIVRFRPVSEVFWEISKDSLEALQHLLENGSNFNNETGSIRMNVDFAVQRQRAGSKEPVVHTTVFYVDITPTSPPGAWDGLRKALNVSANEKSEPVVLSNVLPYFLTVPNEGQVKPTTYIHEVFVKSKEDANASFSSLTLALSAHDDTGHSNVWVTQTKAPNSDMTKIMDIFERKKVVYTPDDRGLFYMDTVIFVDRVFPDYILKYAQGGIIAMYIALVLFISRIIRGAVTNQPLDVIISEIPNPDHLLKICLDIYLVREAHDFILEQDLYAKLIFLFRSPSTLIKWTRYKPKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z769</accession>
    <name>A0A914Z769_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome o ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z769"/>
    <dbReference type="WBParaSite" id="PSU_v2.g774.t1">
        <property type="protein sequence ID" value="PSU_v2.g774.t1"/>
        <property type="gene ID" value="PSU_v2.g774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g774.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17579" checksum="50C24E746966457E" modified="2023-02-22" version="1">MADLPDRCCYWCCNYSALRDHTGDPWENGRTLEWAIASPAPFYNFSETPRVQDVDAYWDMKKRGVKRKTDKFKPIHMPRNTGTGFIIGMVCIALGFAGVWHIWWLAIAAVLSIIAISIIHSFNNNRDYYVTAEEVQRVEDEHTLKLQSLGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7M6</accession>
    <name>A0A914Z7M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7M6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7902.t1">
        <property type="protein sequence ID" value="PSU_v2.g7902.t1"/>
        <property type="gene ID" value="PSU_v2.g7902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7902.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14789" checksum="F23E74F9326AE859" modified="2023-02-22" version="1">MMSGGEEAEMKRIWGAFYGQVIGDALGVTCEFLNVQKTTNEMARIREKAGRKNKDSIFPMVGCEEMGVEAGQFTDDTEMALSLARSLIAKKDFDKVDVACAYSFWLCATQPTDSGMTTRNALTADIFYDPGILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7N0</accession>
    <name>A0A914Z7N0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7N0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7907.t1">
        <property type="protein sequence ID" value="PSU_v2.g7907.t1"/>
        <property type="gene ID" value="PSU_v2.g7907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7907.t1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45842" checksum="09B197B54F938EEB" modified="2023-02-22" version="1">MQHITVLLTIIILLVIGFFTLTAVIVLMTEDPTKSNENSRIELIKEHRKQFYKLENSGEVYSPPHKSYSLRPSMTNARTRLTTTVATTFSTSTLPDLITMPTTTKEYQTEATTHFSSKKPFRVSPVTVKVNHTIFHGLERMETEKSEIKEEVDVEIAQLHLTREIRAPSNDKISTLMIKNSYLYLPLTTGDILVYNLSNYDLVTTFKTSLSFYRIGFLGQNIVATEIRKNTLSILDEQGRVAKQLKMLYDSKDMQIYEDQVYVLSRSNQDIFVYDKDLILKNTIHFKNENQETCNVILPTSNGIYVSCQSSILQLESSGKIIKKLKAPGGSYSLGIGLFKETLFAAKRGEQEIHAFDQETGEYKIKLVNSGRGSAIWSCLAFDGNYLFALEYMQNIVKVFLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z831</accession>
    <name>A0A914Z831_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z831"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8024.t1">
        <property type="protein sequence ID" value="PSU_v2.g8024.t1"/>
        <property type="gene ID" value="PSU_v2.g8024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH/HolE_GNAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47408">
        <property type="entry name" value="PROTEIN CBG01304-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8024.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36476" checksum="3A2A822A953537A8" modified="2023-02-22" version="1">MENIEFIEFCGLDRWKDAVENTGKYEGWILADEDLDRWREGFGEGNYNLLVAIEKKTNKTVGHVATAFYESIEGSDPLLTIGMFFVLPEFRGIGLGWKLFEKVVQNPKFHGINWGLNAIPKMTKKYATKFGFDKYPKWQISTFEAAIKDINPERLQSNHLIKNVSFKEVNFESFIKYDTVMTGGIRRDKFMEKWLDSKNAFSKIALNLENKKIVGVCNIRIAFQKQLAIGPFYAETKSIAENLLKDVLKIIPDINQYSKLWLYPATTNQEAKEIFYNLADGKIQEYNVSFGQFTKHVIEVNTSKIYSVTEHAMSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8Z1</accession>
    <name>A0A914Z8Z1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z8Z1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8297.t1">
        <property type="protein sequence ID" value="PSU_v2.g8297.t1"/>
        <property type="gene ID" value="PSU_v2.g8297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038161756" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="38"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8297.t1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48971" checksum="7D37FE2FE496B7CC" modified="2023-02-22" version="1">MKWILQCLMLLCFGDVALSHFQIPGVPIVVLPEYTAYGIKNVTRKGTEAFLYLGLPYVKPPVRFEKPEPLTVTPLSFLKPKNATQWKPACHQVVDVYPSAITSEDCLYLNIFTPTKVGLKNLPVFVFIHGGGYSYGYTQAYGYEYFVDNFISQNIIMVTLQYRLAHFGFFATRDHVINGNFAHFDQLEALKYIKRNIKAFGGDPNKITLSGHSAGSTSTHALSLSPKTKDLYNQEIHIAGSNYALWGIASEMVFNHSELIGTQVGCAQANTLERKKCLQKVDYKKFWEARVELGLPDFVPDKFDMLYWTSNFDNDFFGGKTLDELQAAAPKRRAMYGVDFGEGLLESIITDNPITNVFSKSRGAYTYENRTLANAEKIRGVLLQMLTDPKFNSTTENVIVDRIFAYYNIGIGANATDPLHYWYKLTEVRHTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z903</accession>
    <name>A0A914Z903_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z903"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8305.t1">
        <property type="protein sequence ID" value="PSU_v2.g8305.t1"/>
        <property type="gene ID" value="PSU_v2.g8305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF31">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE ASM-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037915490" evidence="4">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8305.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25515" checksum="4809CCEEA63E01FD" modified="2023-02-22" version="1">MKFFGILLIFLVFWSSSFAAPVEHKLESASCNSCNLIVEVAHDVLGDDALDDCIVDFISWICSALKIEDHFVCKGMVGDFKEQFIYVLQELIVEPKEICGLLVKGCDGGFDPYNATWFLPMPGVKPPHKTPTPIPSGKPTLRVLHLSDLHVDNDYIIGSEAKCDEPLCCRPPKDTNEAFVQKKDIAVPAGKWGTVGDCDAPYWLLEDMMKDIAANHKDITVIHSRLIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z976</accession>
    <name>A0A914Z976_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z976"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9225.t1">
        <property type="protein sequence ID" value="PSU_v2.g9225.t1"/>
        <property type="gene ID" value="PSU_v2.g9225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="138"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9225.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37551" checksum="85E3F02CDBB33789" modified="2023-02-22" version="1">MTLKVDDDYSSSNGENSMDYSTSTFVRGSTVGELDVQIEKLMRCEILSENEVKVLCSKAKEILIQEGNVQSIDTPVTVCGDVHGQFFDLLELFRVGGHSPDTNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRMMLIRGNHESRQITQVYGFYDECIRKYGSVTVWRCCTEVFDCLALAAVINGHIFCVHGGLSPSIQTIDQIRVIDRKQEVPHDGPMCDLLWSDPDETTGYGVSPRGAGFLFGSDVVQTFNEANGIDLICRAHQLVMEGYKWHFNESVCTVWSAPNYCYRCGNVAAILELDEMQGKEFTIFEAAPQETRGAPAKKPQPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCB0</accession>
    <name>A0A914ZCB0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aECM cysteine-cradle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9962.t1">
        <property type="protein sequence ID" value="PSU_v2.g9962.t1"/>
        <property type="gene ID" value="PSU_v2.g9962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055352">
        <property type="entry name" value="CCD_aECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37435">
        <property type="entry name" value="PROTEIN CBG14344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23626">
        <property type="entry name" value="CCD_aECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="aECM cysteine-cradle" evidence="2">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9962.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26583" checksum="F3BE3ABB0ADF41E7" modified="2023-02-22" version="1">MIEQGTKAAPIDLGNILKTNAFTTTTMPSSSGENVNTKFVISDELARRIEQARQLREEQKRLEILASKERDVQLEAQAERRRIIEEKLARLAQTERWQHELLEKAQLRQRAFANANMASSEQQQQNTKLLLTLPPSTITSTQTIPSTTTMPLTTIISSQISESESEAATTLPDGMPQHCAPVQKFLTVFKVKDPKQWLRENCVFVKQYFPSASCSQIEALLSACFISASSEQSLLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCE4</accession>
    <name>A0A914ZCE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZCE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9387.t1">
        <property type="protein sequence ID" value="PSU_v2.g9387.t1"/>
        <property type="gene ID" value="PSU_v2.g9387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9387.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="31749" checksum="D989E4B3518675D8" modified="2023-02-22" version="1">MDEKACEKSKPMKMCILGGGGYLGQCLAIDLQADGHTIVMLDLNFAHFSNINVNWKNVKLIKGSILDRSKLEEALNGCDACFHLAAYGMSGGASLNEKMTHLVNVGGTNLVIEACIKAKCRRLIYTSTVAVAFGDKEVFNLDETAPYLTKFLTPYAKSKCIAEQRVLQEGKNGTLESCALRLRGIYGPGEIRSTQKTVDMVTKGFIRATFSKSEPCLSQYSSAENTSLALRKAEISLRIGHESKTNGNAYNILDGGEAVSNIGFWFPLFTHCEAPLPAFKIPYYFSICLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCF8</accession>
    <name>A0A914ZCF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SANTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9609.t1">
        <property type="protein sequence ID" value="PSU_v2.g9609.t1"/>
        <property type="gene ID" value="PSU_v2.g9609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039110">
        <property type="entry name" value="KNL2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015216">
        <property type="entry name" value="SANTA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16124">
        <property type="entry name" value="MIS18-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16124:SF3">
        <property type="entry name" value="MIS18-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09133">
        <property type="entry name" value="SANTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANTA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9609.t1"/>
        </source>
    </evidence>
    <sequence length="466" mass="53310" checksum="560E7CF6F7174C7B" modified="2023-02-22" version="1">MATSQIKRIKEWRPSFGKSSNVMIEGHLDGDERKRLWRSSVIEHREKPRILITKGGGKYQLVGSINKKACIERGFSLHIIEMFVDGFPDDWRELLQTQYTNITQNLRTFTTTANNDIDHNFDHFTPPRSKKKPPKETKAVVPYKTTPNTVATTRSGRVVKPRIATWANQNIVYDNNGSVIEIRNPTTTTSQSKKVNQNLEKLCDVLGVETPEASQISEKSANSPKRRSTEKPKTKKKKRENNLVGYSDSEYDSIDELSSDGIELLETGDTPIRPSKQTAKKLQKRNRILESSSEDEAKEVPIKVEKVRRKRTATKTSTKDVPNKKGKKNAPISKGLSLKKARQQTITPTPVDFDDPVVEFPESDKENDVAPKKWTAKEKDRFLELLKIMNPINDYDWERFRENNKSDRTIEEMKEKAKELRWKPSRVASREETVNQIDQITAKPGTVAHIVYASESSKSKLFICEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZF48</accession>
    <name>A0A914ZF48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZF48"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8903.t1">
        <property type="protein sequence ID" value="PSU_v2.g8903.t1"/>
        <property type="gene ID" value="PSU_v2.g8903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8903.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32293" checksum="52599AE53372D1FA" modified="2023-02-22" version="1">MTSIEKFQASISADPSTSDKRMNCIQDFHYTKEEYKSAALIKFFQKTKAETNEYPRAAVFCNDSSTCLKLTLALNYSNINSLPLCKTAMNQFNNGEVVVLIFTDDLVQDVDFSQFDVIINYDFPKDIETYFDRMKYVCTERNVKYITFTVPQTDNLLVREITRTLGVTFNDIFESLTSFSTTPIPLKANHVKIPTINLVQPQEQQPLVRSFEAAESETDSENTADESEVSMVIKNAANVVGNQIHGVFWDIVDAFYDDAKFFLFFTVFSVVAFVLTYPFMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSS4</accession>
    <name>A0A914XSS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSS4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1001.t1">
        <property type="protein sequence ID" value="PSU_v2.g1001.t1"/>
        <property type="gene ID" value="PSU_v2.g1001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1001.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19302" checksum="F888C4A1BE2CAEE5" modified="2023-02-22" version="1">MALGMDGEEILSTFYNAVTYSRDGENWRIPYSVDRFKGMKIIGDMLDADTGEVVAESGRKLTARAAKQIAEKGVKAIRATDDDLLGSYLAEDIVNYATGEIYLEAGDEIDEKTLKVLLETGGNEINILDIDHVNVGAYIRNTLAADKNQSRQDALFDIYRVMRPALRSVGRWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU09</accession>
    <name>A0A914XU09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU09"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11444.t1">
        <property type="protein sequence ID" value="PSU_v2.g11444.t1"/>
        <property type="gene ID" value="PSU_v2.g11444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11444.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17579" checksum="89C78275F0627A0B" modified="2023-02-22" version="1">MAEVLPESSGDYLWFAFINGAIEEVLISDNVTISNPALLGYESNYAVNTFVSTSGYLNFQFLNQIFQKQLWTAFDAIVLPFSPSSASECPFSGQIITLDNDTIIPISSEYGIYDITPSNNCSWTFKIDDPGYQFKIYIKQLTSDYALFIKNDNITNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW80</accession>
    <name>A0A914XW80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12195.t1">
        <property type="protein sequence ID" value="PSU_v2.g12195.t1"/>
        <property type="gene ID" value="PSU_v2.g12195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12195.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32705" checksum="0201DD3F2A78CCC4" modified="2023-02-22" version="1">MLYNDTSKRFKFDHEKADAFRNQISNEHSNAHKNSFSLGGMFEAVGINFGFSHGEKKTNANSAETEKKSKDNIHVDDVQKALEKKSSNVKWTGKKFEQKNFDLYRINTKNLHSVTEQVFNRVVVSKEQSGQQIDIKMETNTMEFDHIYDEKTTTTTSTSTTTTTTTTQFPPSTVATKIIEIKCNPNNGGCINHVAPVGLGRGAAPMGQAVAPYRGPIQNEYGGYNQYRNPNGYGYLNPVQYRNPPQYRNPMQYRNPVQYGYGGNAGMRAPVQYRNPYQNRQYYPYRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWH8</accession>
    <name>A0A914XWH8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWH8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11319.t1">
        <property type="protein sequence ID" value="PSU_v2.g11319.t1"/>
        <property type="gene ID" value="PSU_v2.g11319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11319.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31744" checksum="0BF40951DE5AF010" modified="2023-02-22" version="1">MKLQGFCSGLPTQNRAKVFIEQILPVVKPLASDANQHVKVSLASVVMELAPLLGEQTEEHLLPIFLTMLRDDTPEVRLNIISSLDKVSKVIGQNELTTSLLSKIVPSNEDILRVRSALVEYILPLHAERHHQQFFEEKLLKLCMTWLTDPASAICEAATNILKQLYDKFGAEWTVQHIIPKVTELSKDANCLHRMTCLFSVEALAQLLDKDGVKEHLLPIIKKLAEDPIPDVRINVAEAIIEVGKALDPGLLQSEIKPIIQKLSEDDEIDVKVFAQKAKETLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXT3</accession>
    <name>A0A914XXT3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XXT3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12012.t1">
        <property type="protein sequence ID" value="PSU_v2.g12012.t1"/>
        <property type="gene ID" value="PSU_v2.g12012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF898">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038160304" description="Metalloendopeptidase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="105"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12012.t1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42474" checksum="3F3556BDB52ECF44" modified="2023-02-22" version="1">MKCYFGDLVIILIILHPLVYAYPSRSPRNVPNHLDHASKLLKLFLKMAENVPLSENKPTLHTQQPISYKIIDKTEFAANKEILTNVFESDIVMTEDQMLDVIGTFQQRVRGGCYSSVGKIGGRQTASIGYGCESAGIVAHEMGHALGFWHEQNRDDRDEFINVNEDFILRGTKGNFEKRNDIDNTEDIPYDFGSVMHYGPQAFSNDYKYITVETKDHRYQHTIGQRSGLSFTDVKQANMMYCRNICPNNGLFCQNGGYQDPKNCLICKCPPGLTGDCTILAPSTPGCGGEVFALPTWQTLTSSIVDSPTLPPPPLAPWEGDGLTSFLGGEIGIDNTLEHYIFNDFPKMFKRSKPSPDKPIDLLTPFVTSFLRSIKRNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYQ0</accession>
    <name>A0A914XYQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Double Cache domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYQ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1307.t1">
        <property type="protein sequence ID" value="PSU_v2.g1307.t1"/>
        <property type="gene ID" value="PSU_v2.g1307"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g14032.t1">
        <property type="protein sequence ID" value="PSU_v2.g14032.t1"/>
        <property type="gene ID" value="PSU_v2.g14032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004010">
        <property type="entry name" value="Double_Cache_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08269">
        <property type="entry name" value="dCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double Cache" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1307.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14032.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13402" checksum="0C7C8205E0FC5EA5" modified="2023-02-22" version="1">MRAENDTYYFNIYDTGYRLLMHPFRKDLVGKDMKDFRTDDGVRIYYDQVEAAKAGGGFVNYRWAKPGSKGDVEKVAYAGLFAPLELGGQQRRLHGRRAEAGAGVHCHHGPGSSATASPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYZ5</accession>
    <name>A0A914XYZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12436.t1">
        <property type="protein sequence ID" value="PSU_v2.g12436.t1"/>
        <property type="gene ID" value="PSU_v2.g12436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12436.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24369" checksum="8E6477927BAF1A9A" modified="2023-02-22" version="1">MYCCLKFWNVKDSRRRRLSIRSTDIRYVQQIHKLMERQKEVEKMRIAGTKVVSKHEDPKLLKPKSKAISQPPPLLVPPARSRSASPGTRSRSSRSSSNTDPQTIKKLAKLREELEHYKIDHKIQVRRPRQPPFSSSEGGTPLLGGGRKRTWEDLPNIEIDTDYVDIEAALTPTLKRIHLPNLVDVGVQTTNSLEREYPSSRKIFQTSFETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZS4</accession>
    <name>A0A914XZS4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZS4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12464.t1">
        <property type="protein sequence ID" value="PSU_v2.g12464.t1"/>
        <property type="gene ID" value="PSU_v2.g12464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12464.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10631" checksum="E7364D343E240A6C" modified="2023-02-22" version="1">MNTRLQTGAEKIKTLESQLAKARKPNPKFEKLRNEQSDLRSRLQASVEKVRTLESQLSEARKGNPELEKLCRETSDLKARLQAGDGKENYVGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0A2</accession>
    <name>A0A914Y0A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0A2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13634.t1">
        <property type="protein sequence ID" value="PSU_v2.g13634.t1"/>
        <property type="gene ID" value="PSU_v2.g13634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13634.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28848" checksum="FB27CACC851F2D40" modified="2023-02-22" version="1">MRVAHLRFIERISQLFGEIQSSQDIIPTDNEINHRRGKRSIVAASLGAIATSAIWYFVDNVRNVNSNLNQINKDIEAMKNIQQDMMASIKTLAKANIENQLQIEADFGINGISKMMNGGLHPEFISIAEILETFSNRYFIFESLIYKKHPSSIFSFAEVAVERWDTTLEEASLKVCLPAIKEQQLYVSTTIINIGFFVEHEFARYNTPELSVTVNGTEYAYSLKNCTMKVKLIVTTLIINFTRIIGFISFMSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y292</accession>
    <name>A0A914Y292_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y292"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13355.t1">
        <property type="protein sequence ID" value="PSU_v2.g13355.t1"/>
        <property type="gene ID" value="PSU_v2.g13355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13355.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20204" checksum="30C5258B9189767D" modified="2023-02-22" version="1">METERVSMENFALIKVLGKGAYGKVFLVKKVGGHDNGRFYAMKVLKKERVAHKQKTLEHTLAERTVLERLKGQPFLVNMVYAFQSDAKLHIVMEFVGGGELFTHLCKKKQFDVPTSRGVLAELVAALELIHRNNVIYRDLKLENILLDSDGHIKLTDFGLSKELKEQRIANSYCGTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2Q9</accession>
    <name>A0A914Y2Q9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-conjugating enzyme E2 J2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y2Q9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13734.t1">
        <property type="protein sequence ID" value="PSU_v2.g13734.t1"/>
        <property type="gene ID" value="PSU_v2.g13734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13734.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25330" checksum="E34C398D69D6BFB1" modified="2023-02-22" version="1">MTGPSMTAVTRLKKDYQRLVKDPVPYAIARPLPSNILEWHYVVRGAKDTPYDGGYYHGKLIFPADFPFRPPSIYMITPSGRFQTDTRLCLSISDFHPDTWNPSWTISTILMGLTSFMNENTPTYGSIQTTVHERQTLAKKSKRFNLKSPRFCEIFEDLAEELRKEVAEEDIASNGIKVDQENDKTSKSRDSYSMTANIVLFTGVVALFFAVRYVIISAHLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Q7</accession>
    <name>A0A914Y4Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Q7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1518.t1">
        <property type="protein sequence ID" value="PSU_v2.g1518.t1"/>
        <property type="gene ID" value="PSU_v2.g1518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1518.t1"/>
        </source>
    </evidence>
    <sequence length="712" mass="80336" checksum="64A1C17870B7B3CA" modified="2023-02-22" version="1">MLTTDEVYLVEKIVDYRVTEDGIKEYLIKWEGFDSNGVPYDDTWEDEKNLECQQMLKEFWETRKKCRKRSRTRSSSKTKTATSSIIQPPNVLSFEDTCLSPPSIDLEDVFDIAPSTPPRSIIECFRDATTAANSPPNKKSKLNEIKKCLNKSNEKYRKKSKRDKSKCRDEASTSTSSFSKSKKKDKKKKKDKHRDRDETGDKATSKKSHENSSAILSKEKALVDARKVPPLIIIMSDGTSEVDADKNKSNNTNANENVVDEALIKTEAVNMHNNENQARITVESSTSSLILPSPSILTSAVETLPTSDDVNENNQTSQTLSTAIEDSNSSDVTVLSDPLNNLQITQNNESGLHFCISLLNIPDQNETTNIIIDTESPMNDTSESLTSVEIVEVIEDADTVQSSESCLNDKSSNVSTIPKTLLPILSFAEMNGEQTFIASKASLSLTTIVAIEVPHNCPPPPPSPHSPTAEPSLSPTPPKQQHKCFETEPTVNEFVKNATIFNINHHQIIDISSKLWKVICPECTQKCSVTDNSVEYAFALLKYDTKNYFLIKIKNFLNELFLIDGDTFKDACPKIYSNFASDTREYFDTLGDLEMEIEDQKSIIASHHEPNGILHHFNNNDEATFQNTQISYESERVRQAARDIVQLFLLELQFEIGKFMAKTVEFSDLKKFALEYFHERIPMYKIVKQEAVEKNFESFYFNLFKNPSSSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y564</accession>
    <name>A0A914Y564_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase FkbM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y564"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14379.t1">
        <property type="protein sequence ID" value="PSU_v2.g14379.t1"/>
        <property type="gene ID" value="PSU_v2.g14379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989:SF3">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989">
        <property type="entry name" value="UNCHARACTERIZED DUF13 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14379.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26765" checksum="DDFE17C7EB0A9729" modified="2023-02-22" version="1">MCTNNFTKMLPMKEFYNEDEIKYGFLPYSPEDECNVITLGIGRDVRSERELLRKFNNCKFFGIDPDAKRSGRIYKAVLNGTFVEGLVAAKSGEYEASILDKFDDLSYKKEKLKHFSFENLLAEKYEHDVIDYLFMDIEGAEFELMKELIYFPSKYPKICQINVEYHNPFLENRGMDFFEVISKSILDGPYIPLKVDTKMNFLFNRIFFVNMDKICVDKFLRNVTHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5B3</accession>
    <name>A0A914Y5B3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5B3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1443.t1">
        <property type="protein sequence ID" value="PSU_v2.g1443.t1"/>
        <property type="gene ID" value="PSU_v2.g1443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1443.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18268" checksum="3FA2C7AA58740FFE" modified="2023-02-22" version="1">MTVDGMNQLPDNSSYGPPNGFIPNLMNSSWRDPPNSFNNAWVQPQLPLSNSWKPSDNTMPSMSLPPPVTEYVILDQDPHKMGMDLPPPPPPPFIPSSFSQHTASQLNSAQEFYFFNPPNPNVYHPPRCISESSHTTSSSPPVNLDGEADMSISSGSRNSTPKNMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5K9</accession>
    <name>A0A914Y5K9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase class I/classII domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5K9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12968.t1">
        <property type="protein sequence ID" value="PSU_v2.g12968.t1"/>
        <property type="gene ID" value="PSU_v2.g12968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="5"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12968.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26817" checksum="3E7C97B134533F69" modified="2023-02-22" version="1">MTPDTKLLSITVPHNPTGTVIPRGDLDAIISMTQKKNIKLLVDETYRDMTFTDKLPVAASLATNIISVSSLSKTFGLPGIRVGWLICRDKEMMKKFLAAKEQMIICGSIVDEEIAYRFMETRQQKLPAILAEIQSRLSIVKEWMTESSDILEWIEPKGGVVCFPRIIAKITDFEEFYQILNEQFKTFVGPGHWFEMEKCFMRIGYGWPKTHQELKKGLENISKAVRICLEKQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6C9</accession>
    <name>A0A914Y6C9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA 3' end processing protein WDR33</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6C9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13208.t1">
        <property type="protein sequence ID" value="PSU_v2.g13208.t1"/>
        <property type="gene ID" value="PSU_v2.g13208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13208.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="38897" checksum="D903E0D05A7932E9" modified="2023-02-22" version="1">MTLAWHPIHETLFVSGGGDGSIGYWLAEPFSELGLYDGAHDQAIWALDWHPLGHILSTGSNDNNTKFWGRNRPGDTLEELNGMMASAKDTHHQPINNFQYYNYQVKFHEEDLHRDYPIVPGLGVNEHVLNDMKEISILPESIPGSTTLPDDYGPRNTFTSNIGAKRTLIKQPPPKKAQRQFERTWTTTKPGSDIPEELLPASFISPPLPSNGPSTSLLGAPRTSLLPRPGGSLLGRPTIPPAILEQQSIPLQILPPSSGGESWRTGIVSPPIIIKEPPQWFQRSGGYSDGSTFPPPPSSSVSHGIGFPPPPSAGGGGGYGYDGPSIEHPYSNDGRKRRADDSEDPSLNGNGKIHRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7G9</accession>
    <name>A0A914Y7G9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y7G9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15403.t1">
        <property type="protein sequence ID" value="PSU_v2.g15403.t1"/>
        <property type="gene ID" value="PSU_v2.g15403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15403.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16439" checksum="F6ED9D26610740C4" modified="2023-02-22" version="1">MLKERIFHEIYKPAVKQYFTILEEFASKTTRNGFLLSSGISYADFGIANLYEIVNALNPELVLEFPSVKELAQRVFALPQLQYYLKNRPPLAHLKPSPVIFKIPPRIFLKPPMKKLCVGNYNKIDDQDNNVEKGILVCRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7N8</accession>
    <name>A0A914Y7N8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y7N8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15472.t1">
        <property type="protein sequence ID" value="PSU_v2.g15472.t1"/>
        <property type="gene ID" value="PSU_v2.g15472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15472.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30727" checksum="17888357CD48D5C8" modified="2023-02-22" version="1">MAAGGEEAPKPINNPVINRPPCLTSGEKLQNRFIVENLIGQGSFGQIFRGIDLSKNNRKVAIKVEPKFINANAADGNDPRRLIIEKNVLIELRGKRHIPLIFASGKAPSNENPYYVMEFLGDNLTNLRKQKTQQKLSQSTSFRIAQQVALALENLHQIGYIHRDIKPSNCCIGMENKRRIYLVDFGMCRKWRLDDGKTRSPREKAPFRGTIRYASSRALTQQECGPTDDLIGWLYSVIELYQGHLPWAKISDPQELIRLKAEMPITALFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7R6</accession>
    <name>A0A914Y7R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7R6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16245.t1">
        <property type="protein sequence ID" value="PSU_v2.g16245.t1"/>
        <property type="gene ID" value="PSU_v2.g16245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16245.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21482" checksum="6344970838F7A871" modified="2023-02-22" version="1">MVETINFCQLEYCPTHRKTVIEFGENLEFTVSYDRCKVFRINNIKGDLEITKITRDKDGREIEVKYENNAFYSEESADFTFYITAKIEPEELCDDENDIQIDIKNSYDVIIKGKEMKKDAVLKANPKMDANLNLSFRFNPNVYHPTVYTDSVSQILPLNESRPESIIPSYLSNENSKLFKNCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7W3</accession>
    <name>A0A914Y7W3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7W3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15545.t1">
        <property type="protein sequence ID" value="PSU_v2.g15545.t1"/>
        <property type="gene ID" value="PSU_v2.g15545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15545.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13196" checksum="C8E1073EFDC8E246" modified="2023-02-22" version="1">MNGDRNINVSCKFSFPLVNKLLTENEKLQMTSTSNVYVTRFGTFNELMDPANNFIVDDYLIIKMEAILIIAKNKTDTVSNIQQSNCCKLGSKLWERDDKDFVIIVDGKEIKVSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8B1</accession>
    <name>A0A914Y8B1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8B1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15512.t1">
        <property type="protein sequence ID" value="PSU_v2.g15512.t1"/>
        <property type="gene ID" value="PSU_v2.g15512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15512.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10752" checksum="37D090C99AB05B68" modified="2023-02-22" version="1">MSEESQEAIRIRVGNRKRRRQFDDNPDSDAEFNRLLKQHEKTIDEAEKAKEERRATRKATSEAKKAKKPRREAPEHDDTCDACNSDGELILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9J5</accession>
    <name>A0A914Y9J5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small integral membrane protein 14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9J5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15438.t1">
        <property type="protein sequence ID" value="PSU_v2.g15438.t1"/>
        <property type="gene ID" value="PSU_v2.g15438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020309">
        <property type="entry name" value="Smim-14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11027">
        <property type="entry name" value="DUF2615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15438.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10420" checksum="4C4CDA26D26FC60B" modified="2023-02-22" version="1">MSDDPCECVFSHEAMMRRLLSILRQSQDECTEDNCNSDGTGSGTNTMMMMALMGIFAVVMYLNRPNSLRLPPNNTDGKPSNEADRDPPPPPPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9Q5</accession>
    <name>A0A914Y9Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9Q5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16942.t1">
        <property type="protein sequence ID" value="PSU_v2.g16942.t1"/>
        <property type="gene ID" value="PSU_v2.g16942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16942.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28399" checksum="2F4C1B12258361CC" modified="2023-02-22" version="1">MIPFRIARYAEQLLNSVIHQVESCNLKPEFFDTRASRAQSTRPQSSLYLASTPTKKSRFDETVLNGEGYRYFAAVEHEKTQRYPNQIIHKENHENQIYNVVSIVLSAERGAAAFLQERITKFFSPEAIHTLLAFLRFYADYREKDISRFPCHEKLPEIVQKNLEELPSIEDFSAERDALLDNLNIPVLDEPAATTSGAPMEIDQDFDNDFDFHDAPTDFDDVPSSTQQPLSAKESQDIFAHYDDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBF7</accession>
    <name>A0A914YBF7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF19 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBF7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16612.t1">
        <property type="protein sequence ID" value="PSU_v2.g16612.t1"/>
        <property type="gene ID" value="PSU_v2.g16612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037355623" evidence="1">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16612.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25699" checksum="B440E39EED61E320" modified="2023-02-22" version="1">MKTLKFLSFLLFPISLVISSPCDISGEAAVVRCATDLVLHQFGGIKEDAKFSDQPFIAVPLRQISLMCNKYDSFLQCTNFVDDECRTSMLTNLMSLWNFVCAADFTKSVNENLHCFETAENDINIQRCLIEAMEDFDGDIGNTTVSIAHRREHRCALAKKQLNCFTEFQFLKNCQSAVELQHKLLSFIVNNVSDLSSCEIPSFFAIIDKFKVVERGFIAFLKGFKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBH2</accession>
    <name>A0A914YBH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-L-isoaspartate O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16769.t1">
        <property type="protein sequence ID" value="PSU_v2.g16769.t1"/>
        <property type="gene ID" value="PSU_v2.g16769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF9">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16769.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24886" checksum="37EFD66A6FAE835A" modified="2023-02-22" version="1">MVNIFQKLFNIVFNKKIGYDYDEDWLDNQITIKKLKAAGNLRSPDIIAAFESINKAWFMPFKDEYDNSDINMEYKYAESDLLIHLFSPSIYSTILENLDLQQGHSFLNVGSGTGYLSSICGCLIGSKGKNIGFEIHPKLIDFAFTVREKLEAALASKIWCPPEFKCINIFDFKTDEKFDRIFIGASMMENQRTFICRMLKPFGIAILACDNKVCLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBQ7</accession>
    <name>A0A914YBQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBQ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17635.t1">
        <property type="protein sequence ID" value="PSU_v2.g17635.t1"/>
        <property type="gene ID" value="PSU_v2.g17635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17635.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13854" checksum="F35AF97D948726A2" modified="2023-02-22" version="1">MEGCSKYCSFCVVPYTRGPEVSRPFDDVLMEVADLADQGVREVTLLGQNVNAYRGPTDVAGEIADFAMLLEYVHEIPGIERIRYTTSHPKEMTSRLIAAHGNLPKLVPFCTCPYRPAATVFWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBT8</accession>
    <name>A0A914YBT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16223.t1">
        <property type="protein sequence ID" value="PSU_v2.g16223.t1"/>
        <property type="gene ID" value="PSU_v2.g16223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16223.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="11466" checksum="3A4F86863AA307E9" modified="2023-02-22" version="1">MVSADSAPLTIALCGGWFDGIHHLATAVVEPVRGSVGHAVFQLRLVHYLQALVVWGCRSGLGNLDYGGTVFRGGEYALAGCGGRVCRQHLCRGQASALVSGASSPGAGTGSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBU7</accession>
    <name>A0A914YBU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBU7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16762.t1">
        <property type="protein sequence ID" value="PSU_v2.g16762.t1"/>
        <property type="gene ID" value="PSU_v2.g16762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1440.10">
        <property type="entry name" value="SecA, preprotein cross-linking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612:SF0">
        <property type="entry name" value="CHLOROPLAST PROTEIN-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="Pre-protein crosslinking domain of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16762.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12106" checksum="C090309ED096730B" modified="2023-02-22" version="1">MILGRERRIELPANLRPLAKLHIDTLIENCKQAFFLEMNTGYVIDVDHTGKLQTSLEPVVTIIDQNTGADLASSQWTGGLHQFLQLKHGCRLSAMSLKAVFMSNVTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD24</accession>
    <name>A0A914YD24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16640.t1">
        <property type="protein sequence ID" value="PSU_v2.g16640.t1"/>
        <property type="gene ID" value="PSU_v2.g16640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16640.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11421" checksum="D38685D89A55CBE6" modified="2023-02-22" version="1">MDVSGDLLIEHCIQLYEFVDQYQMETIRDIIETYLIKKVSQSNVCNLANSAASLKNSKLSDYCYDFLLKCMKETTAVADLDLLDKETAVKLLKNAFTKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDJ3</accession>
    <name>A0A914YDJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDJ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16819.t1">
        <property type="protein sequence ID" value="PSU_v2.g16819.t1"/>
        <property type="gene ID" value="PSU_v2.g16819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16819.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27435" checksum="93D628B45C1B6586" modified="2023-02-22" version="1">MEEIDQNLQKWYADGVIFDSTKDIAKLWVYEELMVKWSPNATTILSLFIPKINKCDLRSLYIWDQNLTFDEYQFLTSSGSLEELSLFSCTISHSDTTLVTFDQLFEKLHQLKSFDMRCDQNYSSMFKKDTFKKFADILPRLKELSYFKIHGLTEAFDFTSITDFLLKNETINITLDYRFEALSDEYLGILEKFIAKIIENPPEKIPVINSPGLRNCNIYDEYRKLCFGKVYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDM0</accession>
    <name>A0A914YDM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDM0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17394.t1">
        <property type="protein sequence ID" value="PSU_v2.g17394.t1"/>
        <property type="gene ID" value="PSU_v2.g17394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000012">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036950365" evidence="9">
        <location>
            <begin position="20"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17394.t1"/>
        </source>
    </evidence>
    <sequence length="516" mass="56931" checksum="F85B863C145BB834" modified="2023-02-22" version="1">MRKFIALSFVALFVFGVFSDEDAGKEKDKKYGTIIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFSADTGDRLIGDAAKNQLTTNPENTVFDAKRLIGREFTDKTVQADMKLWPFKVTNKNSKPHVNVAVGSDRKEFAPEEISAMVLTKMKEIAESYLGYEIKHAVVTVPAYFNDAQRQATKDAGTIAGLNVVRIINEPTAAAIAYGLDKKDGERNILVFDLGGGTFDVSLLTIDNGVFEVLATNGDTHLGGEDFDQRVMEYFIKLYKKKTGKDLRKDHRSTQKLRREVEKAKRALSTQHQVKVEVESIMDGEDFSETLTRAKFEELNMDLFRGTLKPVQKVMEDADLKKEDVHEIVLVGGSTRIPKIQQLIKDYFNGKEPSRGINPDEAVAYGAAVQGGVISGEEDTEIVLLDVNPLTMGIETVGGVMTKLITRNTVIPTKKSQVFSTAADNQPTVTIQVFEGERPMTKDNHQLGKFDLTGIPPAPRGVPQIEVTFEIDVNGILHVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE60</accession>
    <name>A0A914YE60_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YE60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17579.t1">
        <property type="protein sequence ID" value="PSU_v2.g17579.t1"/>
        <property type="gene ID" value="PSU_v2.g17579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="7">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17579.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13311" checksum="8317864D70D0B639" modified="2023-02-22" version="1">MSLRAFYKNADLLDINTIYSNDITLMLSTYGVEACHRSIVKEMNNVFGVYGIDVNPRHLTLVADYMTFTGSVAPFSRTAMASSTSSLQKMTFETTMNFMRETLVHGRFTEFYFFVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFC2</accession>
    <name>A0A914YFC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18996.t1">
        <property type="protein sequence ID" value="PSU_v2.g18996.t1"/>
        <property type="gene ID" value="PSU_v2.g18996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18996.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13977" checksum="A4F8069758F58337" modified="2023-02-22" version="1">MQLRKAMMGAMFQSRQSMMEPRMQQIMQRIRQIHQNENISFSQERSQIKQVIASAPPEVRAKFQEMRERFRNGGGGAGAGMMMMGRGGGGGGFGGMMGNGGGMFGGGAQGFWTFWKRFSRSIWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFF2</accession>
    <name>A0A914YFF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent RNA helicase Ski2/MTR4 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18044.t1">
        <property type="protein sequence ID" value="PSU_v2.g18044.t1"/>
        <property type="gene ID" value="PSU_v2.g18044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase Ski2/MTR4 C-terminal" evidence="7">
        <location>
            <begin position="190"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18044.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="34305" checksum="2C7E7954E047C06C" modified="2023-02-22" version="1">MKEKNEILFEHSIKYGLEKLIDYGQACDKLELIRNIPYENIIAICNAKFKNFNVKEVTDYFRSIMSRYHSPSQSIINLMTEMDMVIKSYIHNKNDKNFLFKIGEDLTTNDPEINDEICEFIQLRNCLLDDNRYLCRKCFDFDSHIHLVRERKLLEIEYEKLKLQTSFSALTLTDDYINCIKVLKELNFIDKDNILTIKGRVAAQINEDTVLLTELIFENKLQHRTCSEIVALLSPLIAQHNFSRYKEKERTCEIKTKLPEISEIINTLKNEIAKLADKIDLIERKFNVVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFH3</accession>
    <name>A0A914YFH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THAP-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17507.t1">
        <property type="protein sequence ID" value="PSU_v2.g17507.t1"/>
        <property type="gene ID" value="PSU_v2.g17507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17507.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32168" checksum="492BDA9BB0D6F636" modified="2023-02-22" version="1">MSPCPVCGNHVDAKSGKLLPTSKKTLQDYCHSMGIPNTSFQDIETRRYVCYSHFGKNQFYIVDGQKKLNDDPLELEGDIIGGMKFVEHLECGHDEPSTKVALDPSSKSFGVLQKSFTSDSFLHDVQNCSPHFATSLNESFHSLKTNKYCTKNYYYGLKGFTNRTQLAALHHNHNILDTESGKRKKIGKKEYAYRAKHRDGEFVTKQRKTPPDFSWKKTILQKSRIHIPTIHHKKTQGEIEGDITDISENEDEDNPPSRDEYFGRMILNEMGLEEEDNDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGL1</accession>
    <name>A0A914YGL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18456.t1">
        <property type="protein sequence ID" value="PSU_v2.g18456.t1"/>
        <property type="gene ID" value="PSU_v2.g18456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18456.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15162" checksum="E038F581F54B877B" modified="2023-02-22" version="1">MAEILQKKMELENELEQTKIQDEQKSKEWEAAFEARLKSVQNDYQKEIENRRVQEESQIETLKRINEEDEQKLKALTKTLGELQTVVAAKTQEMKDIKIVTHEPKPNFCQQSIKIAENKLIGSSDIGELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGL5</accession>
    <name>A0A914YGL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGL5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18460.t1">
        <property type="protein sequence ID" value="PSU_v2.g18460.t1"/>
        <property type="gene ID" value="PSU_v2.g18460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574:SF1">
        <property type="entry name" value="CLC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35574">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18460.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17272" checksum="A8A2BAC2FAE27241" modified="2023-02-22" version="1">MFKHGLWLDCTKSQRMAGNLPQYNDRSLHCTYKFDQKQSEVIDQNIDDIDGNSAAAEAAHHQFYFWHKACLVCILISISTGALALISGTCSPCSPSCALIFSILTFIAFLASLSAAVIFFFAAHRVDHRFVQGLVGTYEVKKGHNISSNPSKKNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGP5</accession>
    <name>A0A914YGP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH marR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGP5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18627.t1">
        <property type="protein sequence ID" value="PSU_v2.g18627.t1"/>
        <property type="gene ID" value="PSU_v2.g18627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039422">
        <property type="entry name" value="MarR/SlyA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33164:SF64">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR SLYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33164">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH marR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18627.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11749" checksum="FE5D2321A976B5CE" modified="2023-02-22" version="1">MPLLMIGRSGGGIRQVALAQQLGMEGPSLVRLLDKLCASDLVRRESDASDRRANLLWLTDAGHALVSELEDQLIGLRQDVFGELSMDELHAVLKAWRLLAEAADRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGX3</accession>
    <name>A0A914YGX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1858.t1">
        <property type="protein sequence ID" value="PSU_v2.g1858.t1"/>
        <property type="gene ID" value="PSU_v2.g1858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1858.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38423" checksum="FA9ABC0D6D04FFC8" modified="2023-02-22" version="1">MYEEAYNKLVKRKSKEIAELERQLTVKESGALSVEDFNERIVKAREAEKENMAKFNELSKNVTEARRRLEDTKSERKNLFMATLKKMQNEVDYYYKHLYHDSTAQAYLNIVGSEEPYKSKIVFDLIVPGKSRNSIDVLSGGEKAMAILALLFAGKPKNVNCILMDEFDEALDRRNMLLVSRFIDTMSSRGIQFIFISHRLELYAYANRLIGSSIHCKNACNYGSIIFTVDVRDYLGEIGKKQHYDPDDEIEVEKKQRSKEEFSKAVEIKNDEIPTDQGINAEVENLMEMYGTQNVKEFLDGMDEEDAFQKCFNNSDVQDLKELFARMTFGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHR4</accession>
    <name>A0A914YHR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16847.t1">
        <property type="protein sequence ID" value="PSU_v2.g16847.t1"/>
        <property type="gene ID" value="PSU_v2.g16847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13244">
        <property type="entry name" value="PH_PLEKHG5_G6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF11">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="148"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16847.t1"/>
        </source>
    </evidence>
    <sequence length="910" mass="101348" checksum="60374A3F1CC55E1B" modified="2023-02-22" version="1">MSLKLRLQLGKPRSLSTCPVNVLFAEDSSQSLSAATTPIHSNNPLGELVAAYPPRRGSHSIESCPDSVEHHGSMIFNEEHLSGTISARGKTSRKGIFSARDNKLTSAADRTLTIIVGARCTDLSILEIENHWTEIVKKHTQFPESTQKQQAAIWEIIETEKRYIKSLQNMDDLTNVLFELQRQGYLLDIKPAKVFLNYGDLLRNNLEFWERGLLPMILESRESGAPLSPSLMYNGFAQILQWSKFYITFNVGHADSLNYVRKTQKDNEKFGEFVQWCESLNMMNRQTLIDNLSIPMQRLTRYPLMLKNVLKATTDSNEKNNIQEMIDLAELATRQLNYEMNNKDLQIQLIEIMKTIESYDVIDTKEFDELLNLKNSYHHFNLLNPMPYVGTHAYRRIITKGDLKMREPPRQAAKSDVHCILFTDMFLICKSSKKDNTRLKVIKSPLHISTLICIRDPNGLGFNLISINDFGYPIFFKTMLTANFEETRRWMEMIQMAQEEFRRIHTHDIEFVLNEREKNRAQFKENIRSQTPTSAAATSWINEKQPGIAHKKSHSMDSQVVAASRPSSAHLRKSETLNSAEQLDRRHFNDTPGSSGSKASLASSYAEEQSPSLTASASARNNSPARAAQIPSVISMNGHTPNSFESDSVHSSMTPPLAEESSEEAAEAACISPQGNHAIFEDVGSCSSPIDFGTSGDSLTSQNLRQLALNNGRRFEKRYHTVGEIDSQRPVHANGPTAILKRFSWNVSSAMSGSSRKISSKLNELNGRRYSQSTVGSSDSFGSSTSGISSASSQDTGTIVSTTMTDTSTLTNIAAEIADPHISTVLIGGDQLSPRPKNSSPTTEKVSSVSINLEKHSPLPDSKLPSSLSPIPDVPPPESCSGSDDTLTLQKTSSELLKFILDDNIETSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHZ5</accession>
    <name>A0A914YHZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19105.t1">
        <property type="protein sequence ID" value="PSU_v2.g19105.t1"/>
        <property type="gene ID" value="PSU_v2.g19105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19105.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11411" checksum="17A5C4DD523E860F" modified="2023-02-22" version="1">MVPQVTPLSFTQGPIGVAIDASHDSFQMYHSGVYFEPECGNSSEALDHRVLVVGYDTHPEFGDYWIVKNSWTEGWGDKGYILMARNKDNHCGIATRTSYPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIP3</accession>
    <name>A0A914YIP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19177.t1">
        <property type="protein sequence ID" value="PSU_v2.g19177.t1"/>
        <property type="gene ID" value="PSU_v2.g19177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="67"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19177.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29067" checksum="CA92F87CA09FC133" modified="2023-02-22" version="1">MQKSIFFLFRPAEKKLKYEKGDGKTTPVESGDNDSEESSDDDIKDSDSDSSTPIDDMLSIKIDEKEYKISGFIGSGSSGKVYRVTDEDGKFFALKETKSDDVEELICQEYAFLKRLDHPSIVHAIGCTKSESYFYFVMDLITVDDYPQDKNESDIRDLLFKLLEALELIHLENIVHCDIHSGNILYNRRNFIIIDFGCNYGLIQKDLTDMATFFYNILEENKITSPNSVAFIKCLENEYSPDKARESWKLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJV7</accession>
    <name>A0A914YJV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19150.t1">
        <property type="protein sequence ID" value="PSU_v2.g19150.t1"/>
        <property type="gene ID" value="PSU_v2.g19150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19150.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21990" checksum="01B1DFCD7A96E435" modified="2023-02-22" version="1">MFRANAYGQPSYYSNMMPPTFQQEPLNHYNHVPYQPNQRGSIIIIHHSNHYESMYPAFKPTLNFSQPPMGTFPAYFFYNSYAKPSFNQMQAPFVAPFFGPYNFGNSMKFGVAQPPSTHFPLAQIDSVYCMDFMDDESPHASISVTTALVHTESTEKTVIDSELSSGTENYYFEEYDPTPTPSISFMQQKIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJW2</accession>
    <name>A0A914YJW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19814.t1">
        <property type="protein sequence ID" value="PSU_v2.g19814.t1"/>
        <property type="gene ID" value="PSU_v2.g19814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19814.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23930" checksum="31B9CEBD1502DB34" modified="2023-02-22" version="1">MSSEGRGKPVLPPVQRQIIKYCIDNSKDDLGERIYRRVMDKRDDFRGFVESLPKAQRIELSYGLRDFLLKKEFGEKHVLFRSNGFRPDFFAVTADAMTTECVFLDSAVHQSTETLTAWSTLTSTMFSSVRDGFYAEMRRIRRASNCINNAKNKGSVDLSSDTSKDDDQSSRRSNSPADDDARVNSSHNSSGNTTNPLQGSESAGNFLCPPQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKF2</accession>
    <name>A0A914YKF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g200.t1">
        <property type="protein sequence ID" value="PSU_v2.g200.t1"/>
        <property type="gene ID" value="PSU_v2.g200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g200.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34584" checksum="05ECDBDD3644B4EC" modified="2023-02-22" version="1">MSSGEGPDHYDSPLIDIRPVDIENDNSRLCPDAGIPLQTYKNDDTKYVVELEASGNLECQVFMELPLDMKIEDVILVEAPRLPLNASFAGHDASYWWKSEGDAMLHPSVKFDGSGNIQIDLLNVTKAVPYFLRIGQNQPIPSLQFTFNGCVGSKFEVYLNLRDNLECRTGIYYTSNGLEISTKNSAWKTINDTTKTPVLIFSGTKLFVKVKSPLSIHEFDVCEIPNPLNVPLDQLVLQLGQYETLGGCTKAQVLLPRHDVFNGTEVLINSPRVASTASNETNDNATIAATKNKTGDDAAAAQLQWWWFAVIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKS9</accession>
    <name>A0A914YKS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17930.t1">
        <property type="protein sequence ID" value="PSU_v2.g17930.t1"/>
        <property type="gene ID" value="PSU_v2.g17930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17930.t1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50635" checksum="EB38D0818B5C032C" modified="2023-02-22" version="1">MDIEVPMKLSNVSASFNTANRSNYNVPPPIRNSYNQQFAPPPPQQEPYIRNDQYQRYQDVQANRHSGTQNSYNTLNSQHLSNQEPYISDQGYRTIPPQSFHSEPRRDRYDNWMPNYEQYRPRRRVWRPPVTNNFNFINVPFNHQFYGYPQQAQQMIDYAQSAASMATLRTSFQHDYNIARNTQRIITVKEEDEDDGDVVYVGTHQKNPKLISSKRKRKSSSTGTSSSSPQGSDESVTIETASNSTLTSQVPSKQSRSDSKMQQWPRSPSSSSAYSLEPNPFSSAPELTTYQREVQTPIPEMIGLKISTVADAKVDDDVEDGEIVAENDCAKIFPTKSEIPLDRLPEFMPKPAKEIEPNNEEHNTSVVSTILPPSHPDYNPLLDDFDDDGPTTFDASSFALDDEDDLLNDYDAEAEKKAQEDEDHVLKKFPDLKLTDNSDDHMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL07</accession>
    <name>A0A914YL07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20033.t1">
        <property type="protein sequence ID" value="PSU_v2.g20033.t1"/>
        <property type="gene ID" value="PSU_v2.g20033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038650">
        <property type="entry name" value="PADR1_C_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20033.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11221" checksum="C0F7B596F763BDA5" modified="2023-02-22" version="1">MSKFLCYFHLFQYILSTNEHDYKCDGGDKKGCSYSIPNPSRKALKIPKDLKSKGFLKGRKLPLLKERAYPPGSEIHMNALSDNPIDKMKRQRQNSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLQ3</accession>
    <name>A0A914YLQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L23/L25 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20492.t1">
        <property type="protein sequence ID" value="PSU_v2.g20492.t1"/>
        <property type="gene ID" value="PSU_v2.g20492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20492.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16554" checksum="06F6AEAAC7E85676" modified="2023-02-22" version="1">MAPKAKQVAVAPKKDATKSKAAAKAAAQHKKKIRTRVQFYRPKTLKLSRTPKYARKAVPTRTKLDSFGIIKHPLTTESAMKKIEDTNTLVFICDVKANKHQIASAVSKLYNIRPLKVNTLITPLHNKKAYVRLPSDVDALDVANKIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM49</accession>
    <name>A0A914YM49_9BILA</name>
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        <submittedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM49"/>
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        <property type="protein sequence ID" value="PSU_v2.g21410.t1"/>
        <property type="gene ID" value="PSU_v2.g21410"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF61">
        <property type="entry name" value="SRA STEM-LOOP INTERACTING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21410.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12376" checksum="FD6B1FBBDC15CA7A" modified="2023-02-22" version="1">MRLTIVRFLRQATTGYVSNRENSIMVKNLSWLSSPMEVKEFFSKYGQVKHVFLPFDEKQGIYCGYGFVEFENQSSVQDAFADDYHRPQLDGNYLKIAKRHIKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMI4</accession>
    <name>A0A914YMI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21544.t1">
        <property type="protein sequence ID" value="PSU_v2.g21544.t1"/>
        <property type="gene ID" value="PSU_v2.g21544"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21544.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11286" checksum="5CF2C7A263EDED5D" modified="2023-02-22" version="1">MSAFARVTLASYQSYTRDPAAWVANADNIGKLSRLTGATPQEIPNVLAGSGFLTAADQIKTLGQPTAKALADTSAFLKEQGRIDEVLPDYAGYTTSKYVEAAASQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP87</accession>
    <name>A0A914YP87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19170.t1">
        <property type="protein sequence ID" value="PSU_v2.g19170.t1"/>
        <property type="gene ID" value="PSU_v2.g19170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19170.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9419" checksum="3F970F167304ED6B" modified="2023-02-22" version="1">MKAFNAPPSDLSSKLNTLLLSQIGGLPMITVGWKEMNWDNFWQTLGKYESQYGVGSIFSSYVSVDYGHTQQHALYINQYVSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPV0</accession>
    <name>A0A914YPV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPV0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21049.t1">
        <property type="protein sequence ID" value="PSU_v2.g21049.t1"/>
        <property type="gene ID" value="PSU_v2.g21049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="12">
        <location>
            <begin position="880"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="569"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21049.t1"/>
        </source>
    </evidence>
    <sequence length="958" mass="109043" checksum="59D53A9E8BBD2F68" modified="2023-02-22" version="1">MFVLLHHYYMATKDNYMPVKNKQKKDHDNANLNLNQNLGISKEICCLESVKNDSRKVEKVEKVENYDLDYSKTKHNSNLWNKSNKQLPSISLNNDSEEKDEFKKAKHSNINNGSTLSLNIGIYEDLDQFMKLKEEANTFFESHNYTEAIEKYTTILRILNLSPENQALIFSNRSAAYQSINSESALTHATADAKNAIALYPNWWKGYYRMAEIAMKKSEWGLAKEYLLQAQVLQEASENLGEKLKMVNREMERLKLDTYKISPSKPSEMEITSDTPEVARRSPKKVDASSNSQTRSSSPETVLLSDSEVVPQTPEAASEPPKAPQTPKASLLEGKASKYRAFFDKGGKCKLCGESISIKKANNLKRHLERKHKKEFQELEKSVEVVAKNQKIINFPVVKNAGPLEDLVSFASTTTFSLHLVDNRHFKKFAKRIPNFKAPGKRKLRSLMFKKLKKGKYDLKKKLQGLKKKFSIIIDLGTTKSMRHSFLGVIAYYIDPTTFEPRVEAMALKLLEGGVSHTGSYIRTAVEGVLQEYGLVLDDVNFIVTDGASNMSKALKDLKESVIVEIENEAISREESEGNSNIDTDVEDNDSEKSDDPESMDEEEREDDILNTSLEDFLDNDRSYTFVMIKQLKCLPHSLMCSLKDLFKADELAKALHKRVMAIINKFHHSHKATDSLKRRAGKLLISPAATRWNSLCSTYERFLEIKTYIESICLRQNWEFLTTVEIRRMENIVAACLPLKIFTKTLEGEKAPTVSLVYHGLKHLIAALKEQENAYAKRLADKLASRFEYIIDEKHPAFDWKFKLSTLFDPQVAHLLTENEVVEMLPKLYQQFVNIGEDVQSVPIPQLQMPSPFGFGTIMVQSTDTDTSATPFNDEMLAFYKDIRRSYKSTAAEYWKASQSKFPSALKLFIHYLSVPASGNPVERLFSQMTLHSVGHKANAGPLYLEAKTLLSFNDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQC4</accession>
    <name>A0A914YQC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQC4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2228.t1">
        <property type="protein sequence ID" value="PSU_v2.g2228.t1"/>
        <property type="gene ID" value="PSU_v2.g2228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053031">
        <property type="entry name" value="Cuticle_assoc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34396:SF25">
        <property type="entry name" value="BOUNDARY ELEMENT ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34396">
        <property type="entry name" value="OS03G0264950 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="211"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2228.t1"/>
        </source>
    </evidence>
    <sequence length="468" mass="53352" checksum="8645BC844B0C190D" modified="2023-02-22" version="1">MTLGKALQNDLKSQRLQREQNENSLSSTSSPAPTELSDDQKTSDTKNKEKSPKRKRPRRNPVWVYFEIRDNIAYCMEDGCKYNTGSVYSTNLKVHLKSHHHEKYREVLLAEYRNQMAQQTQQGQSLCLAAPAVMGTTLMIPNNVDQTEKKEITERHPTLGSMLQVKKPVVPQIIEKPLASSPLLAAALKKSTSPCSNDESFNDRMKKRKRLRRHPVWNFFDDLDDKNIGCLQCDFKTSSGFTTNLKMHLKAHHRNDYIQVMQMECEQRKEEGCIDSAPQGKKKKRTAEELETMLEAYKAKHGTELDDIQGNISPQALENIATLLSLSNNLKMEYDTSTPIDYDDESVSSPEELQPAEMTFESLKAQLEDEKPLISEEIEKDEKDDESLAKFREFMANLTQLSIDNNAARDLIKQTRDVALGRVIKEIGIQNISLITSHVFRQLLIALDPSYKLPGDIDHLRQLAENSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRC4</accession>
    <name>A0A914YRC4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paramyosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRC4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3313.t1">
        <property type="protein sequence ID" value="PSU_v2.g3313.t1"/>
        <property type="gene ID" value="PSU_v2.g3313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-0518">Myosin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="12">
        <location>
            <begin position="5"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="11"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3313.t1"/>
        </source>
    </evidence>
    <sequence length="659" mass="75895" checksum="628E9C86444CEE03" modified="2023-02-22" version="1">MILLNNVNVQLDNLQHVKYQLAQQLEEARRRLEDAERERSQMQAQLHQVQLELDSVRNALDEESAARSEAEHKLALANTEISQWKNKFDAEVQLHHEEVEDLRKKMLQRQAEYEEQIEIMLQKISQLEKAKSRLQSEVEVLIVDLEKAQCTIALLERAKEALERTVGELKQRVDELTVELEAAQREARAALAELQKMKHLYEKAVEQKEALARENKKLQDDLHEAKEALADANRKLHELDLENARLAGEIRELQTALKESEAARRDAESRAQRALAELQQLRVEFERRLQEKEEEMESLRKNMQFEIDRLAAALADAEARMKAEISRLKKKYQAEIAELEMTVDNLNRANIEAQKTIKKFSEQLKIVQASLEDTQRQLQQTLDAYALAQRKVSALAAELEECKTALDNAIRARKQAEVDLEEAHGRINDLQSINNNLTAIKNKLETELSTAQADLDEATKELHAADERANRALADAARAVEQLHEEQEHSMKIDALRKSLEEQVKQLQVQIQEAEAAALLGGKRVIAKLETRIRDLETALDEETRRHKETQNALRKKDRRIKEVQMQVDEEHKNFVMAQDTADRLMEKLNIQKRQLGESESITMQNLQRVRRYQRELEDAEGRADQAESSLHLIRAKSRGSVVAGKGSSPRVYVMEDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRQ8</accession>
    <name>A0A914YRQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20080.t1">
        <property type="protein sequence ID" value="PSU_v2.g20080.t1"/>
        <property type="gene ID" value="PSU_v2.g20080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20080.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12463" checksum="4700B41F56016742" modified="2023-02-22" version="1">MPAQQALDMIPPAVQSLTFDTFCFTEGDLVTTRIEALCNPGASVTLFTSNVPNDAVVGPLLAWGFLGFYVHRRTFGNLYEMYHLEGNQRILVGFILPAVVAVAAPDDDDDDGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS70</accession>
    <name>A0A914YS70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g302.t1">
        <property type="protein sequence ID" value="PSU_v2.g302.t1"/>
        <property type="gene ID" value="PSU_v2.g302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g302.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16625" checksum="846FBA40E3BCFEE3" modified="2023-02-22" version="1">MESCMKNAIIALKHGQMAEICEIVKFLAACRQFKLRHSESAVMQICSLIYRNDAEIREFVVTAGKNIFFSGNSNEVVSEKSTVQNLMQVMQHAKLEDRCVLSDTLVFIFESEHLKQGSLKFLWETAERSSFDLSTVAVQILQPYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSB5</accession>
    <name>A0A914YSB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSB5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3613.t1">
        <property type="protein sequence ID" value="PSU_v2.g3613.t1"/>
        <property type="gene ID" value="PSU_v2.g3613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3613.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22700" checksum="FF8EE2B5948329A6" modified="2023-02-22" version="1">MSEIIKPLGSNLLKMKPKKFFAKYKSPICSMDFSADGKKLVTTAENNYISVYDVLEGDLNKIINSKVYGAGHVLFGAHPETIVVSSTLKNHTVRYMSLYDNKCIRVFTGHNERITNMTLSPIRDVLITCSDDKTVRMWDIRQNECTHKMECGTFGALTSVTPDSLVIAIALDSKNIKLFDFRSMEAGPFQTFPFEDKLYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSW2</accession>
    <name>A0A914YSW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3091.t1">
        <property type="protein sequence ID" value="PSU_v2.g3091.t1"/>
        <property type="gene ID" value="PSU_v2.g3091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3091.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21096" checksum="45E5D2952A1B2FDF" modified="2023-02-22" version="1">MEDKGIGILKKAQYWKFDGTFEKRPPGFAQVYTIVAVFCDYPERQKSFFCGTVFVKEKDTVAYERLFQKLKDLVGEDIGPKEFGFDHELAALNGANIIFPDAKIILCFWHYPKNLKDYARSKKCSNHLATDKNFQRWLNQLIGSSFLPLEWMTGVVDYLLDNPPELHELLHFHSSLNTLIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTP1</accession>
    <name>A0A914YTP1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTP1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3035.t1">
        <property type="protein sequence ID" value="PSU_v2.g3035.t1"/>
        <property type="gene ID" value="PSU_v2.g3035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3035.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="26149" checksum="6274EF9E63DD4CEC" modified="2023-02-22" version="1">MKPVESLFTQYSKEVIRITECSKCKKVADKYIEYDAVLIFNDLFLQYSAAYRHLLLNTNFDSYARIGMLFILADAYNKWILRQTHLHSARVYDLEWHFYEALIKSTVECLTYLLTAYFFSTIIIGKNEKMHSFKFFFGRSLVGFFGYIFVVFSIIWHLHEYFSYRLLMTFFIFISQIQVQKTLCPSLTTPICIFIVLFSMAARYGSGWTFSYLISTFSTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU18</accession>
    <name>A0A914YU18_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914YU18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4148.t1">
        <property type="protein sequence ID" value="PSU_v2.g4148.t1"/>
        <property type="gene ID" value="PSU_v2.g4148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038162184" description="UDP-glucuronosyltransferase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4148.t1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55265" checksum="58D3322C88D5A636" modified="2023-02-22" version="1">MILFKILLFVTTLFGLRNAYKIGIFIPGVSSSQIIFNQRVGDILSDAGHNVTFINVEMFEFKKNTKIIAKSGSEVWNIDAKSDQACERLVKNTEFIERLKAAKFDVIFAHMADFCPIGLQHVIKAPTWAWISSGPLLDHMASSAGLSLPASYAAPVMADLGDTMTFFERFKSILGHTVTPYAVRAMSADAETEIFRKYIDPNFPHLFEIAKTAPLIFVNTNELYDLPRPTLHKIINIGGIEKPSTVSKALPAEYAKKIEAAKNVVVFTFGSIANASKMPESWKNAFMGAFEKFPYTQFFVRFDGSNLKPPKNVHLNKWLPQVDLLQHPKTKAFITHGGFNGLQEALVAAKPLLVVPLFGDQFKNARIAEKHGFGITVKKSEMSEEKVTAALKALLNDPKYSNAVKQMNAMIKKQPVAPETLLIRWTEFVAKFKNLDNLRPVGASLDTITYYNIDVYATVLSVFSFILFVLYKFLTFLFLKIARLVGLRKEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV79</accession>
    <name>A0A914YV79_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV79"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3879.t1">
        <property type="protein sequence ID" value="PSU_v2.g3879.t1"/>
        <property type="gene ID" value="PSU_v2.g3879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3879.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11827" checksum="53710BA9D80CD16D" modified="2023-02-22" version="1">MPLFHKQIWSTKWYIVVMLILPIICVAHRFTAEGMYQINPAGYISVGYVDKNFETFGLTVAAIIYGINAFISICLAILTVIKHIQLRNATALLTADTSVKLLGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY23</accession>
    <name>A0A914YY23_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YY23"/>
    <dbReference type="WBParaSite" id="PSU_v2.g50.t1">
        <property type="protein sequence ID" value="PSU_v2.g50.t1"/>
        <property type="gene ID" value="PSU_v2.g50"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="9">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="10">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g50.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33065" checksum="D993F3FFAC0BDBDA" modified="2023-02-22" version="1">MVGISYDNVIYKTVKNAIIAQANAAGFVKAEGGVIDEITNIVCSYMMSISVGCKQYSELAGRSTSNSFDLISALTDNGCELIKLKEYMLKNPSVKSIKVPTITTLPSEHVIKVGEERSLPSHIPSFLPRFPNPHTYVSTEITSDFETSYAKARELQAQNKRNAENSLFRYALSTHDSYCLFRSLHETVKDKAKSELEKQEAELQAKRARYSDNVSDMFELKETTNSIVRKTIPDYYFVLKPFPVTNPTMLALCDDQEDESHSTMDDQMDESKLTDGVEISLDDMLSPDSTMSDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY32</accession>
    <name>A0A914YY32_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YY32"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5008.t1">
        <property type="protein sequence ID" value="PSU_v2.g5008.t1"/>
        <property type="gene ID" value="PSU_v2.g5008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5008.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="27240" checksum="E4C99084F8F62421" modified="2023-02-22" version="1">MEDESENIVVEENVLQDAVEDIEAGLEENVEPQTAMNSSIPLNFVPGHVLQDAVEDVEKELEELKICEQVYCNKNSEPKPKKQKSNHLIYAPNFIFKHFIRNGQSRSRLFIFPTADKKLCYEYFYDFNREKYMCCGCNNKKRQTSATIEEDENGEDFVKCIRIDHICKLRPFNLDKWESDLIIKAPNFRQITEIIDGESKKFLLLFTSADKKKFFKFAWDHGQQIMYPTRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY40</accession>
    <name>A0A914YY40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YY40"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4866.t1">
        <property type="protein sequence ID" value="PSU_v2.g4866.t1"/>
        <property type="gene ID" value="PSU_v2.g4866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4866.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20671" checksum="247856C371E8802A" modified="2023-02-22" version="1">MCDDAETKLKKVEEDLAFATARSSEQQIEIERLKGEVGMTTKILKEKDQALHDYVELHIQTNEALGSTTIGDEAKLKLDFVQMKVKNDKLQQELRTMTNHRDQLIQEQRLIATHWYQTMLERHGDASSRSSQINGNKNIFEETQPPLSSRPSTSLSTTSAATESTGGFIRQASRRFGIFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYW9</accession>
    <name>A0A914YYW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 54 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYW9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5687.t1">
        <property type="protein sequence ID" value="PSU_v2.g5687.t1"/>
        <property type="gene ID" value="PSU_v2.g5687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5687.t1"/>
        </source>
    </evidence>
    <sequence length="710" mass="81428" checksum="F8BEE97DE3EE9BA4" modified="2023-02-22" version="1">MAGKLSSSILYPPESAMPATEEAIAEVFDEIDVVYFMEDGFDATAYELGKMEGNDFDMGVLGKEMFKLKKQLQVVSKKISGLIAKNSKQFSSQTEGYRSIEEEATEMVKEIAFIRKQLNTAHKEVLNGLGIIANQRKREMLADLKETINSIKTLYETQFRLQELIQEGDFPLAIRLCVEATNATQEFLHFDCIKEVSQKFTKILGTMESHIDDVLATLTLSYDQDRYALVYSAYGMLDNVKGASAKLLAFFRGTIENSARTVLVDRLRKSHPIEKTDSMSYEELCEAIIIDEFIDSIRELGFVLSRCLFVYHEILKFHIEEDERRLCSLPPSDTVDIDSTPIVEKGIMQKSLCDGLYGIFKTASAKFNTLLCCHDLSQLKFDNFLDVVEMANRFRKFGRRYFGNSCGEIAITLEKQTCLYFGRYHRERMDELKMFLENEVFALCPVPVQFTLFELQEFQFLKESCDAFDDDDVHVHHLTDHIGLGEQLDYILLTPETDNPFCTPQRHSVSSSKTIDNDETLRDSLSRSSSEDSCIESFSQVLQSTPNICNTALNLLRFFGRYIRMTSLLHSVAEEAITAIIQLFEYFIYSIFNFFAKDLITEHFEAITFTSLHLRKLIEAIRIRLILENEANEEFKQMQNDRLAPCHLSVCLDISSCETGFGLSERVIGVESVIFLKKQFEFLRPVLQSLLPQNRQLVVLEKLYKEVTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZF3</accession>
    <name>A0A914YZF3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">KCTD8/12/16 H1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZF3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5326.t1">
        <property type="protein sequence ID" value="PSU_v2.g5326.t1"/>
        <property type="gene ID" value="PSU_v2.g5326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22204">
        <property type="entry name" value="H1_KCTD12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057093">
        <property type="entry name" value="H1_KCTD8_12_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23110">
        <property type="entry name" value="H1_KCTD8_12_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KCTD8/12/16 H1" evidence="7">
        <location>
            <begin position="111"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5326.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26206" checksum="C4159F1DF40C7136" modified="2023-02-22" version="1">MEDIILLLCASNKSILTTRKVITRYPECLFATLLQEAGKEESGIIKLNCLERDGILIRHIMNALRHPQEIFLLPDDFSNYNLLIEEIRHWHLDNLEKQIVALTRSNAIPSSILISYHGTLTFGKQGFSTDVNFRKIHRILVSGKMSDCRQVFGDTLNLGRDGDMGEDRYTSRVYLKHTFLEQAFDYLAANGYSLITASAHTPAPNAYTQHKDEQECYMHYSQFTFQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z034</accession>
    <name>A0A914Z034_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z034"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6102.t1">
        <property type="protein sequence ID" value="PSU_v2.g6102.t1"/>
        <property type="gene ID" value="PSU_v2.g6102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF27">
        <property type="entry name" value="PROTEIN CBG26503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6102.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31518" checksum="D9BB797B693E05C7" modified="2023-02-22" version="1">MLYTDTKLLLVKLKEYNISDGNCSKVIKDVFSLASVTANSLPSASTALRSVFLTKVLTSEQLKEILTAALTNGLSSTTGSDETTKHAQKLQAYIYRAFNGKEIQDYCLGILQVLNKSANVSFDTLKKLVDDLGADFADTNKLWKDFLLSIKNAISDQASTQLKFNHLLKQVKRGIVALQEGWDALSDSEKADLCQIRSFFFGERASSLHMIYPKWKAYAEQHGIKHYRNPDLKGHRFNIIFTIANSIYYLKDDLLKFIEFLSTSSVKLDHIKTFLGDPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z094</accession>
    <name>A0A914Z094_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z094"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5301.t1">
        <property type="protein sequence ID" value="PSU_v2.g5301.t1"/>
        <property type="gene ID" value="PSU_v2.g5301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000233">
        <property type="entry name" value="Putative zinc finger protein 362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001172">
        <property type="entry name" value="Zinc finger protein rotund"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5301.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33744" checksum="BBABCAAB85153613" modified="2023-02-22" version="1">MTMREPKPYKCPQCVKTFANNSYLSQHMRIHLGVKPFGPCNYCGKRFTQLSHLQQHIRTHTGEKPYRCKIGGCDKSFSQLSNLQSHSRCHQSDKPFKCNSCYKCFNDEATLLEHIPKHKDSKHLKVHICHYCGKSYTQALYLDKHMTKHNDRRTTEFRIPKQYYGNELSADNFDTLNQLNQFNQLSGFARFQMDAVANVSAANNGANASAAYAYPTVTNPNALIGNAASLSSQLNLFQQQITRQNFRSNGSTPNGNNNERNGSIPGFNMITPLEKINSFNQAPTNGTVAASTNGTNAGGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0X2</accession>
    <name>A0A914Z0X2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Epidermal growth factor receptor substrate 15-like 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0X2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3921.t1">
        <property type="protein sequence ID" value="PSU_v2.g3921.t1"/>
        <property type="gene ID" value="PSU_v2.g3921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF176">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="127"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="272"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="378"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3921.t1"/>
        </source>
    </evidence>
    <sequence length="668" mass="73649" checksum="F5B5B6721EA5CFC5" modified="2023-02-22" version="1">MSNLSEVEIAQGHLQYYEKLYRELNTNNVLDIPAGQAAEFLRGSGIPIPTLSVLWEVADYRKIGSLDKRGVFIALKLVAAVQQGQPPIEASLKLPLDAPKFPNIPPSARASPSVTPGLNEWEITPVEQAKYEAIFNSLGPIGGKLSGEKVRPVLLNSNLPQGQLAKIWELADLDRDGMLDLHEMCVAMHLVYKCIETHTLPDRLPYSLARKGSLAGSRRTSAVQSPTSSRILPPPLSSNSRASSVASVHSDYSRQAGIRSIFDATNSDFPVDKQLWEEDFNRLDLDHDGYVTGMDTRITLMGSGMPQQILAHIWGLVDIVKTGRLNSEQFALVMELIKEAKLGVKLPEILPAHLVPPSLRISLPHMALSPSEKANPKVKELNDEIQKIIDDRRKADIDLAQMEADITIKSSTVKNLEIELNTLAATVKQLQNQKGEASKRLGEMDQKIEAFKATLEEGRKRLALEEDRLSKAKADVAQAKENANAEEQIMFSLREELRNLDNTVYQKKLELNKINQSISHAANEISDMEKKIQKNNTESAKIREKKEELKKILEELERATSPTNDDPLLLKRFDELNPSGNAIGSSTSTHSNLDNAFVSDPFKSVDPFGEDNFDPFGAKRNSNAGATGNFGSFGKDPFAQADPFGSSPATATPTNNFADFAKFSAFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z199</accession>
    <name>A0A914Z199_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 38 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z199"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6136.t1">
        <property type="protein sequence ID" value="PSU_v2.g6136.t1"/>
        <property type="gene ID" value="PSU_v2.g6136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 38 C-terminal" evidence="2">
        <location>
            <begin position="223"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6136.t1"/>
        </source>
    </evidence>
    <sequence length="609" mass="68994" checksum="7DE88DB8EEBC783D" modified="2023-02-22" version="1">MMLGTSKENVTKDYERRLTEGWKKGEESLKTSFSKLATLKENETLPPQTICLLSNESICLLTKSNKRLALTIYNGYSQAVSTVVRIPYYSESADVNGPKGEAVHFEVVFNYLNFVNFTFKLQVVKAFLPKNQLISNDSAEYEIHLPVDLPALGFKTFFLNRSKNKTSPRLPSTIRGSPRGRNYRLKQLRFSRKITGFEEIVKPSVPAPSSTPAPPPPNSPTKITNGIIELTFDESGRLSNYKNIKTNFSRELSQQFYYYESVKRSKENSQASGAYIFRPVMVADSFDENVTIEVINGKHIQEVRQTINEWVTQIIRLISNQNYIEFDWIIGPIFKEEKNATGKEIISRYSVKGLKNNGVFYTDSNGRQLIKRIRNSATFYTFEKTEPISGNYYPVPSRIIISDDKTQLSILTDRSQGGTSLTDGNVELMLHRRMYDDDSFGVEEALNEPGNDGRGLVARGRHWLILESKTTNPNLNLNSQKAQRKSAMELFHSPLISYSPITSQSKYRSLALTEFSGLHKSLPENIHLLTLKQLSPTQILLRLEHFLQNGEDGILAQPSTINLSEIFSTLTILSVEELNLAGTTKVKEMHNLPKSWNRSSRIISSVQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1A7</accession>
    <name>A0A914Z1A7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein KTI12 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1A7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6502.t1">
        <property type="protein sequence ID" value="PSU_v2.g6502.t1"/>
        <property type="gene ID" value="PSU_v2.g6502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01983">
        <property type="entry name" value="SIMIBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6502.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31366" checksum="56FCBB1F487ACB1F" modified="2023-02-22" version="1">MPFLLITGLPSSGKSTIVNRISDYMKQKGIKVAVIREEDYDDFSRASYNDAKKEKQWRSSIRRDVSRNLGKETLVICDGLNYVKGYRYELFTQAKNNKVTFAVAYVNAEVSTCKKLNNFEKKYSDEKIDELASRYEVPDASKRWDSPLITIDIADSCLPQEVEVDFDQIYSLLFETVASKPNLCTVEAVEHSESSFKNAEIVTHEINTVVCKNQKNVHYGGKLQLPHAEKEFIVKKYRSPAELSRLRFQFLNIAKTRTGLQAAGDLYVDFLNSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1U8</accession>
    <name>A0A914Z1U8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RIH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1U8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6084.t1">
        <property type="protein sequence ID" value="PSU_v2.g6084.t1"/>
        <property type="gene ID" value="PSU_v2.g6084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ryanodine receptor junctional solenoid" evidence="2">
        <location>
            <begin position="85"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="RIH" evidence="1">
        <location>
            <begin position="547"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6084.t1"/>
        </source>
    </evidence>
    <sequence length="820" mass="94209" checksum="2AA398C68EBD31A5" modified="2023-02-22" version="1">MLRTSAKSLASYCPPRLTVEKMYPVHWARVPNDCLRTTALKLSDVRGWSVLCDDPVRMLMVYVPEKDMSYDILELIEKEELLVFHRQTLDLYCKLAAHGNQRVAHLLCSHVDEDQIMYAVKNHYLSGPMRQGLHDFLIAVHLQTHAYSRQTTSQEYVIPLITELTGKNVFDPDCEDRYPKILGPVVSILPEMKSEPLKSQITKDMEMKLLPPKINFEALKLHVMTAIRNTTDNAVMSCRDLIGGNNCNHFEPLLKLFDALLLIGLITDEDIIEVLKLIQPAAFDEKYLPGTTSKGLTDIELSEEVKIQLCNILDHMCDIQLRHRIESMVSFCEGFVADLQQDQCRRYMDIKQTDMPPAEAAKRTKEFRCPPKEQMFRLLNCKTKEDRTNMLMDDDVEYDQCPMSESLQDQLRDYCGIIVEKLGCQSEPTAVDKVLPFDSLIGIDPEEEPSWVDNFARLVISMPPEPKKLDLSYNKKGTENFRVMIVQTLRRWACESMIQSNELIRKMFKLLLRQYTGVKELMDGMKQTYVLHDRNRQDVENFIVYLMQIRELLNVQFETCEEAILKRGLWQLMNNRIFFQHPDLMRLLCVHENVMSIMMNVLTAQQSAVSAAEHDGIIAEDGTVVQTNVRDASEMVVACSRFLCYFCRTSRTNQKAMFEHLSFLLDNATMLLARPSLRGSVPLDVAYSSFMDNNELALALKEEELDKVTVYLSRCGLQPNSELINKEYPDIGWDPVEGERYIDFLRFCVWINGENVEENANLVIRLLIRRPECLGVALKGEGQGLFAAFKEAIALSQDIRALEDGEDPQFLHSAVLKEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2K5</accession>
    <name>A0A914Z2K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ATP-binding cassette sub-family D member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67073"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2K5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6123.t1">
        <property type="protein sequence ID" value="PSU_v2.g6123.t1"/>
        <property type="gene ID" value="PSU_v2.g6123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005283">
        <property type="entry name" value="FA_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00954">
        <property type="entry name" value="3a01203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF62">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="118"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="446"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6123.t1"/>
        </source>
    </evidence>
    <sequence length="665" mass="75787" checksum="F14D5F50BC0468AC" modified="2023-02-22" version="1">MAAVFSRLAITGPQIRRLTPTLFGVGAFLIVINAYRRKHGLGRLRSNVPHSKKQENGGKKAAEKSHVDVKFIKKLIRISKILIPNFFSTEVFYMILIAVTLLCRTYADVWMIMTSTGIEAAIIDRNKTLFRDSVFHYLLCMPTVSVVNALLKFSLSELKLRFRERLTNHLYSQYLDGFTFYKMSNLDNRIANADQLLTQDVDRFCEGIVELYSNLSKPLVDVALYCWKLGGALGFQAPSRLFFYLLISGVFLTYLRRPIGRLTVVEQQLEGEFRFVNSRLIMNSEEIAFYQGNEREKQSVMTAFQRMISHLRSVILFRFGIGFCDNIIAKYAATVVGWYTVSRPFFNKSNTNMMAKSKNELIQDYYNSGRMMFKLAEALGRLALAGREMTRLSGFTTRVDTLMEVLKDLQTGKYERTMVADGALAAASSKLLSPGSGELIIRDNIIKFEDVPLVTPNGDVLIPSMSFEVPSGRNVLICGPNGCGKSSLFRILGELWPLFGGTLTKPAKGKLFYVPQRPYMTLGTLRDQVIYPDKPSDMRKKGITDRDLIEYLDRVQLEYILQREGGWDSVQDWMDVLSGGEKQRIAMARLFYHRPQFAILDECTSAVSVDVEGAMYNKCRELGITLFTVSHRKSLWIHHDYYLKMDGQGKYEYEKIDDNVEEFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2R3</accession>
    <name>A0A914Z2R3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2R3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4545.t1">
        <property type="protein sequence ID" value="PSU_v2.g4545.t1"/>
        <property type="gene ID" value="PSU_v2.g4545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="73"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4545.t1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41530" checksum="C2C2AF1CB89FDA8B" modified="2023-02-22" version="1">MNENASRHCDGVQEILSACESALSFLRVQVANIDGSLAHQPDAPSTSVAAPEPQNSIFFQSKSFYEFASLNIKIRKYRYAAYEAFFTSLQALTQRRFPNVRMYVHGSFQQGTAITGSDLDISFDCLNGATYDLGNILVFVKENYRALNLNGTVEYIAARVPVIRLRADGDLFIDISSPGPRHLSRQAGSFIKVLMDARKDLNLYVCILKQAFSQSRVYGGRRLALGGIGITVLVAWVMQQMNLLPFFDRFDAVAEELRPGSPSWKAYWNAHRVQSSDDEAISDNAVRQRFAEILRRLIATDLYYVFSLCGQYPRTILENGLVIFTPPNNAQNAANVVSKQTRLNDLVPLMKHFLTEWIKDPYAFLIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z342</accession>
    <name>A0A914Z342_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z342"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7114.t1">
        <property type="protein sequence ID" value="PSU_v2.g7114.t1"/>
        <property type="gene ID" value="PSU_v2.g7114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037367504" evidence="1">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7114.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14532" checksum="ABAAEBE57E35FEC1" modified="2023-02-22" version="1">MKTLLVIFAIICVSYAFVDVDVDEDAAHSSTTESPTDKPPVEVSTLPPPLSYTKNGTINGIGTVFFEIPVQKSQGIVLTITTNKKIALLFVSLDSNNQLPNADKSDYSVACYGDNSFTAQIQIPSNKFDELPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z399</accession>
    <name>A0A914Z399_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z399"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7171.t1">
        <property type="protein sequence ID" value="PSU_v2.g7171.t1"/>
        <property type="gene ID" value="PSU_v2.g7171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7171.t1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52603" checksum="F7568890FF4168A2" modified="2023-02-22" version="1">MQQQQQHQQMSSQQQQQGGVQDPLSNLRMSLSQQKQLTEEEIKRQQLDQEQYASRFLAAVQERVSQPRPSSASAASQSQSHLNGVANNTHGTSLQNLAATLQQEGLTGGYFDQDVNTYDFEAQHNANPPFQLSHDLLEKIGSLPNKMILYEVQIGLEQLLAEPSEFDAWIVAIRDCLARKDVTTDDLEAAAWLVIEMGIISENAQYNFAKVCTYLYERLSPFKESLLSQVKEFHTYRSQYPLDTVLNILVFIAELYVQAFAPVGIRNHPIPTILYEEFVEILNAEPMTDTLVKRVVQTLKLCGRHLETDIGEKAMGDIFKKLEEFTKEGSRPETLTDNGVCFITNLMHYRSSGWGGSTNDTNATSATSAAIRFAPDNNMDLTEEEIRFLESNGAMEGGSSFSSGPSSNDIYDAEILEDYEKFLRDHAEQTAISAAEKALERLSMEEEDDFESHVPHRDDNKTPTPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3S3</accession>
    <name>A0A914Z3S3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3S3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6541.t1">
        <property type="protein sequence ID" value="PSU_v2.g6541.t1"/>
        <property type="gene ID" value="PSU_v2.g6541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6541.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27044" checksum="810F2E7C59212528" modified="2023-02-22" version="1">MTVIPPSGATTRIHVVSARTTNNPYALIDLRCAKVKTQEHSRFIGIVSFALFICLTVISFMIYEADAIFFIVFGIFIYAFLTESLFRIPRPCGVLLYLVFETLQIGFYIATMIFILVQMAFSSSYYDEDDLCSNTPSFSSAPTTTATTTTTTTTTTHLTVTGNGIKTEAKQFPLTTTTHPPNADCITPITTTEAILDIIVFLLLMTIKIYFIKVFTQFYKYINYQEQHSNELRAQYVNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z494</accession>
    <name>A0A914Z494_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z494"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7515.t1">
        <property type="protein sequence ID" value="PSU_v2.g7515.t1"/>
        <property type="gene ID" value="PSU_v2.g7515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7515.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7241" checksum="58D4E3A2B0B007DB" modified="2023-02-22" version="1">MTATNLIKATSTSILAENSSAPVVGKQQFRIPDDANVNEYVAAFGSRPKVVRTPEAGEKPKPTVFMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4E4</accession>
    <name>A0A914Z4E4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proton-coupled zinc antiporter SLC30A5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 30 member 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zinc transporter 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">COPII-coated vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Secretory vesicle membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4E4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6868.t1">
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        <property type="gene ID" value="PSU_v2.g6868"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Golgi cisterna membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:antiporter activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc transporter 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF1">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
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            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="23">
        <location>
            <begin position="341"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="658"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="664"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004205"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00008873"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
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    <evidence type="ECO:0000256" key="16">
        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00040846"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00042038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
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            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6868.t1"/>
        </source>
    </evidence>
    <sequence length="697" mass="77632" checksum="AD8AC2323F1E2241" modified="2023-02-22" version="1">MRLISGSILMPLQKPCTSGISIRRALHVRIGQLALLNILIELLWFYGITFCGPLRAILVFELNPKIIAIALEALFLGSRTPSQTRGIFMLAVGALALIIMDEDSTVELNHADAHGHQSGFNHIFYHIMGWFGISDHKGGVFLLVIALCLKYVYDATFRSLAVEIGGPKRLYSMVSVISAVFLVPFGVLAMIMTESFYTSLLHFLFLATVAAILVFIVDFFTESTVFERLPQPVLASARWAPVTIYVWALILSWLYYPIGPAGHSLSSGVLVTIICFFAASFILTSPSTTKTVGGYHVSVNREGELFFTRGEAFLQKKSQSILKFCKETVREILANDDSKKIFYFLCVNLLFCGVEFFYGFINGSLGLISDGFHMLFDCTALVMGLVAAVMARSTASRQFSFGYGRVEILSGFINALFLIVIALMILLEAVQRLLNPPEVDTDKLMIVAVLGLCVNLFGMYALHGGHDHHHHGHSHGHSHGGHDHHGHSHGNANMEGVFLHVLADTLGSVFVIISTLLIQFFGWQWVDPLCSLILSFLILGSVWPLLKGSASVLLQCVPNELSHELEHAIEDVLNIEGVISYSQLHTWQLKSDNNILSIHLQITDEANDQNVRQRAIQIFKTAGVQHITVQVEKERFFRKIQNLVPMFRIPARVDKGIYISNHPHSHDHSSHNHSHEHSHSNHSHTHEHNHSSSHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4M7</accession>
    <name>A0A914Z4M7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A914Z4M7"/>
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        <property type="gene ID" value="PSU_v2.g7309"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7309.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8140" checksum="9F4207E947710A7B" modified="2023-02-22" version="1">MITNHGSTAKYVSEWPSSGAVAAKEDQIDPLNAMPPPSQRPSPDQPFPLSTKRQRSSIPKSTTPNDASVPCIFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4V5</accession>
    <name>A0A914Z4V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7010.t1">
        <property type="protein sequence ID" value="PSU_v2.g7010.t1"/>
        <property type="gene ID" value="PSU_v2.g7010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7010.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29100" checksum="AB9A31779FFD3082" modified="2023-02-22" version="1">MGDVQTSYLLSIAENELGVTTACGENGETMIPKDLHTVFSAKSGYEESRKVAQIPKPFMSGEGRPRRSAANSNKAWASLMSKGGHEGDEDFVDEAAAPDTPKGAVKRSASKEQANTPGNTRGRKKKAKLSESGETDSEQQVTSQEQLNSPPHETKPEVKTVVPKAAARSPKKLPPPPKVTKVTPQPAPLPQGNDNIDMIHQDFDRHQADLAEKMEEGDEEEEEELVLVPAHRATTKIPTKGRGRPSVAAKPPPPSMTGMDDANDEVKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5E8</accession>
    <name>A0A914Z5E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5E8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7117.t1">
        <property type="protein sequence ID" value="PSU_v2.g7117.t1"/>
        <property type="gene ID" value="PSU_v2.g7117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="3">
        <location>
            <begin position="158"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7117.t1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29344" checksum="341EAF079F100C3C" modified="2023-02-22" version="1">MIRYSHGFRGDKVAAAQQSGAIGVILFSDPGEVAKEGTDADHVYPNTEWMPEGDVQRGSVIHIFGDPLTPLSPAKSDLYPSRTIDEAKAAGILPKIPVLPLSYRDAYEVLIRLSGDAVPSEWQGGLNFTYHLGPGFREIDSKIKLSVKAKYEKREIRNIVGYIYGKHERDKYVILGNHYDAWVYGSIDPNSGTATLAEVARAMTQTMAEKNWRPARTIMFCNWDAEEFGLIGSTEFVEEFEKILNQRAIVYLNVDLISANNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5P0</accession>
    <name>A0A914Z5P0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5P0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7662.t1">
        <property type="protein sequence ID" value="PSU_v2.g7662.t1"/>
        <property type="gene ID" value="PSU_v2.g7662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF62">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="10">
        <location>
            <begin position="20"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7662.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43512" checksum="A782A0F529F775CD" modified="2023-02-22" version="1">MEAMKEIVGMFEDVPKDRMKNHNYDEMTSWLRHFADEYKSITHLYSIGKSLQGRELWVLIISDNPTEHELLEPEFKYVGNMHGNEVVGRETLLYLIEILCKNYGKNEFLTNMINSTRIHIMPSMNPDGYEIGKPGDRNDLSYLGRANAANVDLNRNFPARYPSHKEESGGYQFQPEVIAVMKWILSYPFVLSANLHGGSLVANYPYDDSDSGKDGIYTPSPDDKLFVELAYQYARAHRNMWKTGRRCGLAAMGDSFYHGITNGAGWYHLAGGMQDWQYLHSNAMEITVEQGCFKFPFDSMYPALWNEHKFSLLSYMEMVHRGVKGIVTDEKGNPLGNATIRIGEGSITGGKNISTTSAGEYWRLLSPGKYKVCFFLYFLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z665</accession>
    <name>A0A914Z665_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z665"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7404.t1">
        <property type="protein sequence ID" value="PSU_v2.g7404.t1"/>
        <property type="gene ID" value="PSU_v2.g7404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="278"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7404.t1"/>
        </source>
    </evidence>
    <sequence length="456" mass="53113" checksum="56C833FE7555637C" modified="2023-02-22" version="1">MANLSDEFHLKLDDGVELKSVEQYKDVNFPSGLIDNLRKSSFSQPTELQQDILKCMLSGVCIAGNVPDNLGAESAYISYAIAACIQAKEKKTYNPEEYQPFALFIAKNEEMAQKLFTLAEELAKDLEVNTVMLTLQQFDNEVHCELALQKCDLVFLTADGFNKYVKDELVKFENLKYLIVHDLDWESEKKRITQFQDMFRYHDFPNAGERVILFFDKNYASVAEDFFRNDKKCYITFGEEDEIRMPRFVTGVDERDLQVVETDEKFEIKVTVAEKDAELTSFFKDLVEKYGTNAETFPRTLVFVNGKETTGRHVKYAIERAGFPYAIIADGNRKRRETRDIIENFNDKCYPVLVACTNLNFSTKFVNVSNVIFYNLPDHFYYYFTFSQLLSEPYNRPQKVISYADGMDYPLFQNFLADAERQNKPTEQYRTMIDALKPIFDALPKRKEDYDDDDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z781</accession>
    <name>A0A914Z781_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z781"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6105.t1">
        <property type="protein sequence ID" value="PSU_v2.g6105.t1"/>
        <property type="gene ID" value="PSU_v2.g6105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6105.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8461" checksum="9478C74B01C0E280" modified="2023-02-22" version="1">MGINAIKDVISEIQSRTNAVIYYANAREELIDLLLYSKVAGSHDEFVSSVDEFLTLMNLRPFQRTETTPNLLGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7L4</accession>
    <name>A0A914Z7L4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7L4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7893.t1">
        <property type="protein sequence ID" value="PSU_v2.g7893.t1"/>
        <property type="gene ID" value="PSU_v2.g7893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7893.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="23857" checksum="802786193B86C701" modified="2023-02-22" version="1">MSWRYIEIKYPDPISEDEKPKDGEEATEEQQDAQILKPPKQMPPRREKEFFIKWKFMSYWHCTWVSELMMDTYFPQLLRMYWRKFDPETPPEVDDGSNEDVQTGQYDYLVKWKELMYDQATWERDDQEIPGYEEQIFKYWLHRERMTGESVPKAIVKKINAYAAEHGGQKYDEDDMKKKRKKAAEKPTINVRILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z815</accession>
    <name>A0A914Z815_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase 25 family member</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z815"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8825.t1">
        <property type="protein sequence ID" value="PSU_v2.g8825.t1"/>
        <property type="gene ID" value="PSU_v2.g8825"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:procollagen galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037884521" evidence="4">
        <location>
            <begin position="23"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="299"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8825.t1"/>
        </source>
    </evidence>
    <sequence length="566" mass="66017" checksum="2D317FA3069BE6F9" modified="2023-02-22" version="1">MVMNFLKYFFILLAVIERKVIANIFANLQPDDGDYRHLYPKVCLSMGIKKHGHILPYSIGMIENLRYPKDRMHISFFILDECDDFNAIKDAKIWSEKMAKIYSSTAVFEDRDNWMEASLQWGRKKTCDYLFIINEDNILMKNVINQLINLTFVAVSPLMNDPFGKHSNVNGLLDTFFVERKKVGSQQVYYFNLPIFINIKSMDSSYLTFDSENVRNFHQTDPTQIFAHSAYSMNIPLFVDNKNFYGYVLDSNFYSPKYHKQLIGYFLANLISEKGAISFPYSNILNPWYPPSSSFGFDMIYVINLKRRPERLQKMDLIMKLLGIKYQVFEAVDGKALTNEDLSDLRFMPEYEDPFAKRPMTLGEVGCFLSHYKIWEDMVKQNYQNVIIFEDDIKFVVNSTNVLNTVMEDLMKTQLEWDIIYLGRKKMTPQGDEFFVQGHRYLSTLAYSYWTLGYALSLNGAKKLIKAKPLENLLALDEFLPIMYDKHPNTQWSKHFNLRDLKGYAIYPVIVTPERYTHDTGYISDTEASTIITIQKSKNQTNFKSIDIADQQSNMHAPTTLAKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8J2</accession>
    <name>A0A914Z8J2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8J2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8995.t1">
        <property type="protein sequence ID" value="PSU_v2.g8995.t1"/>
        <property type="gene ID" value="PSU_v2.g8995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8995.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10517" checksum="BB5879E37CD32A58" modified="2023-02-22" version="1">MDSVVFLVQEKTEDWFEMIKEDEKWRDVCDNVEKDGRTLHEKSIFGFKSGCLVKIESFGRERKVVLVEKRKALWEEVHCGQLGGHFGAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8V9</accession>
    <name>A0A914Z8V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8V9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6682.t1">
        <property type="protein sequence ID" value="PSU_v2.g6682.t1"/>
        <property type="gene ID" value="PSU_v2.g6682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010463">
        <property type="entry name" value="DUF1057"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533">
        <property type="entry name" value="PROTEIN CBG21859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06342">
        <property type="entry name" value="DUF1057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6682.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36682" checksum="BA6B792E2C141C2B" modified="2023-02-22" version="1">MIEKYINETNESNLFTTPVTIKTKNNDIVKLDAIFQDTKPEGSNLGTVVNSHGAPGSHKDFKYINPKLEESGVRIVAVNFPGCGYTEYDERLQNDNYERIQFVQQIIDALNLSQKLIFIGHSRGSENSLKMAANNPEKSAGIISVNPIGIRPHRGTKPIFLFHLLAFLWRIQWLRFFSNWLMYQIYNKFARFKVNNGEICGVAMNLMAGLQYSDALPYIEKFNQSNAKAILLYAGKDWLIEPSVSREFRSCFKDNIEVISKHRGDDSETTENVVNELKNGRKTIGVFCQRDGHFLQKDRADLIAEAVLTILKNHSENSRQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBG0</accession>
    <name>A0A914ZBG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBG0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7589.t1">
        <property type="protein sequence ID" value="PSU_v2.g7589.t1"/>
        <property type="gene ID" value="PSU_v2.g7589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7589.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24059" checksum="BEE91719185B26FB" modified="2023-02-22" version="1">MSNKRIPNLFNFDENNPYFIDFMKKYAEQRESFKFIRMTEDIQHMSNYLNDIRICFIAITVTIYIVLLLWVVLFCIRRNRRNVNGGNRPRPRSQWDYQGENQNPGQTDDLVSVRSDGQVGMSAISTTPAPYTMGRNHRGPTPSFMRHGLQMNHAQQTTRLVADSNEGAPNDTVTTSATTSTTNGRNFDRTITSAGGGGGERSTRHKEAISDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBL6</accession>
    <name>A0A914ZBL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-catulin</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7640.t1">
        <property type="protein sequence ID" value="PSU_v2.g7640.t1"/>
        <property type="gene ID" value="PSU_v2.g7640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030045">
        <property type="entry name" value="CTNNAL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342:SF1">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7640.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24282" checksum="8875933739FDB7E8" modified="2023-02-22" version="1">MDIEDQQKIAKVGLEMKLLTAEVEAEAEKWDEYAENSIVKRAKAMSSMSYNMYLFTKGDGPLKTTHDLFTQAEFFAEQANKMYRTVREFAFEVPGSAEKNDLQIILEKIPYHCQQLQVLVKSPTVGKTATFSKVDSVISETKSLMNEIAKLVTACFVCATKFEIEFRGHSASRGALNDGDYPQRNSRESTLWRRTPSIRRTVPPQLHLSTSENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBQ6</accession>
    <name>A0A914ZBQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9751.t1">
        <property type="protein sequence ID" value="PSU_v2.g9751.t1"/>
        <property type="gene ID" value="PSU_v2.g9751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051357">
        <property type="entry name" value="H3K9_HMTase_SUVAR3-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45660:SF13">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="109"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9751.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33723" checksum="54FE17614D0911DE" modified="2023-02-22" version="1">MRPIPVINNLNNKIPQHFTYSNYNVPSSETRKLIGKTIIQGCQCENENECDSNCACEKSSIIGFDPEARVVSNPINYDYYTDFYVECGVHCGCRGDCKRKILPNNKALKKLEVHWMNGKKFGVVAAQPIAAGMPIAEYTGEVFVAKVEDDIFPPSHYQQDLLIDNDYNKLIIDARRFGNIARLINHSCFNNVLQICVYPSIPDLKRSRPLPKVALVAFRDILPGQELCFDYRAMYFLDRSMPCLCYEPNCHVPPYDHAEKAKSVEDVKKEVIENKQKMLKLFSEAGDVQPVMIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCD1</accession>
    <name>A0A914ZCD1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCD1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9377.t1">
        <property type="protein sequence ID" value="PSU_v2.g9377.t1"/>
        <property type="gene ID" value="PSU_v2.g9377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037668336" evidence="1">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9377.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31701" checksum="D30A5C44EF905262" modified="2023-02-22" version="1">MINFVGKISLFLCIFYVVDSIENPPLNTFVALNQCFELKKGFKIDITEAHMTGTDSIQFKDDCLRACLKTLFQNNFTCRSLMHMPRDDDCVLTSMSEYTGAKVEKVEDFGFMSTINYFENKCAKSPFGKPAATAEASMSSYKGNRAIFQIGEVAGKAPLILALIDGIRANSLVDINIKHEHVKDCFALKRKDVKLSDRLLQMFTDSSGMAVYPWGEADLKILGKNYLGSTVIIIDTMSQKVIDCGIIQIKGNPDEYEAIKSFSSSFSLKFIVAFTFFTFLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCM8</accession>
    <name>A0A914ZCM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8015.t1">
        <property type="protein sequence ID" value="PSU_v2.g8015.t1"/>
        <property type="gene ID" value="PSU_v2.g8015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8015.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13339" checksum="B47553A28E37E9FB" modified="2023-02-22" version="1">MMEKVDKSKHVWFGLRWNAALSNDSAIPLKTPYDKFYKYFVDKMAYNVDGTPVTYFQDFDKKTQQPDGWKQTSPGTITVENCVLCEADTRKWHDYNCDTTTGFSLCRKMASTQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCY5</accession>
    <name>A0A914ZCY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCY5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9809.t1">
        <property type="protein sequence ID" value="PSU_v2.g9809.t1"/>
        <property type="gene ID" value="PSU_v2.g9809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050998">
        <property type="term" value="F:nitric-oxide synthase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF17">
        <property type="entry name" value="CAPON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9809.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8594" checksum="42E2D2A25FCB8EE1" modified="2023-02-22" version="1">MEISRPSSRIEIVAAMRRVRYEFKARNIKKKPVDIVVSVEGVKVVLQRKKKQQKEQTWDESRLLVMSHPIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD17</accession>
    <name>A0A914ZD17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZD17"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9842.t1">
        <property type="protein sequence ID" value="PSU_v2.g9842.t1"/>
        <property type="gene ID" value="PSU_v2.g9842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9842.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13371" checksum="D54A442BBD7DCB94" modified="2023-02-22" version="1">MFILHWAQMVLTGKVEKYDYRSAKKNQQHYGSSKPPEYDFTLVNAPVYLYWSDADWLGDKKDIEEYLLPSLPPQYLVQNNHLSDFNHLDFIWGLNAAKMIYEPIIEICKNDAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDA4</accession>
    <name>A0A914ZDA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator LacI/GalR-like sensor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9923.t1">
        <property type="protein sequence ID" value="PSU_v2.g9923.t1"/>
        <property type="gene ID" value="PSU_v2.g9923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30146:SF148">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REPRESSOR PURR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30146">
        <property type="entry name" value="LACI-RELATED TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional regulator LacI/GalR-like sensor" evidence="5">
        <location>
            <begin position="13"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9923.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15203" checksum="E3375B68B8FDB9DE" modified="2023-02-22" version="1">MIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDK1</accession>
    <name>A0A914ZDK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDK1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9752.t1">
        <property type="protein sequence ID" value="PSU_v2.g9752.t1"/>
        <property type="gene ID" value="PSU_v2.g9752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9752.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10507" checksum="B90899A8C072EC45" modified="2023-02-22" version="1">MSSSTLVPFTSREWQIVQNLYNKNGNDLVLATEILSMWRIRQGSNTPVIFQITDHLLHIDRLYQSTNFKDDFSVKTLLNNYSTVLVRLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEC3</accession>
    <name>A0A914ZEC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZEC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8616.t1">
        <property type="protein sequence ID" value="PSU_v2.g8616.t1"/>
        <property type="gene ID" value="PSU_v2.g8616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8616.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21966" checksum="7C0D4009E5B5366F" modified="2023-02-22" version="1">MFPTTNNYFSSLFYKLINVKKEAVSDLIPIKNEKYCKILLERSKCLERVDSSCLDPEHLAQAAGEKKPELLDQIFFDYAYQFSCLHGYKPTKADQKCSDASILRQACDPVPLFLVKISRNCLAKKKQLDCRRKVLEQKCKNKDFVQFQDDKERWASEAVLPHCNFNFNIKIKAEAPQKKGIFAKIRGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHR3</accession>
    <name>A0A914ZHR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9846.t1">
        <property type="protein sequence ID" value="PSU_v2.g9846.t1"/>
        <property type="gene ID" value="PSU_v2.g9846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9846.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="17988" checksum="0D2F5F212ECDD50C" modified="2023-02-22" version="1">MDKIVVVCYDAQNVISSVKGECESNQCVFQAGVSEDMGKSILWFMSTPMAKTFTSNICETAVLKSSKVIPSFVTSSSYDSCQLSKSNGNVVKLFVRALPSGCRLKVKNAKIWSPTTPSATTPSESATPEDSSKIGSTVWIILGILLFILVIGFIAFGLVFYVYFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSF0</accession>
    <name>A0A914XSF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Deoxyribose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XSF0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10200.t1">
        <property type="protein sequence ID" value="PSU_v2.g10200.t1"/>
        <property type="gene ID" value="PSU_v2.g10200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000034">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000001">
        <property type="entry name" value="Thymidine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="entry name" value="Pyrimidine nucleoside phosphorylase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00592">
        <property type="entry name" value="DeoC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023649">
        <property type="entry name" value="DeoC_typeII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013465">
        <property type="entry name" value="Thymidine_Pase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004490">
        <property type="entry name" value="PRK05820.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02643">
        <property type="entry name" value="T_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515:SF0">
        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="8">
        <location>
            <begin position="253"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="7">
        <location>
            <begin position="326"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10200.t1"/>
        </source>
    </evidence>
    <sequence length="621" mass="66343" checksum="67EFE8EE24623C5D" modified="2023-02-22" version="1">MTDLKASSLRALKLMDLTTLNDDDTDEKVIALCHQAKTPVGNTAAICIYPRFIPIARKTLKEQGTPEIRIATVTNFPHGNDDIEIALAETRAAIAYGADEVDVVFPYRALMAGNEQVGFDLVKACKEACAAANVLLKVIIETGELKDEALIRKASEISIKAGADFIKTSTGKVAVNATPESARIMMEVIRDMGVEKTVGFKPAGGVRTAEDAQKYLAIADELFGADWADARHYRFGASSLLASLLKALGHGDEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSENGYPRAGDGSGCNGRRSSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSV4</accession>
    <name>A0A914XSV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10353.t1">
        <property type="protein sequence ID" value="PSU_v2.g10353.t1"/>
        <property type="gene ID" value="PSU_v2.g10353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10353.t1"/>
        </source>
    </evidence>
    <sequence length="417" mass="46084" checksum="1FF1F16C080C8F76" modified="2023-02-22" version="1">MRRAASPDSRISSRSPSPNSSGRTSPAITANFLRLKSTNPSTSSGMRKLSSSPHLLGICEETEETIEPLKIPFHSTPRSISTISQKGPHLSRGNRSASIGLGNVTFSLKPSFTKEDSSSAPTTYSSVRVIRPRQAVVSPDMARRYDQHPRLLSRNRRSTSCSSENSETSDDDVNERKLSLIGSKYCKRNSDDKNNDDDAPKGGGGGGGGSNNGPRRSNSMKEQTIPEEENTNEKERSEKEQSSKKAAASKGCSFFLEASPSSSSISDSECFIPFGRQLSTPLQPIMEDNNFNLFNKSQATEDALFDWLKESKNCWENMEEIEEAFKECNKNEKFNFYRLLRRSKSMESLKATDSGLSYTGNSNTVIIVNVDEEIPRTESLEMTTTDSGCSSDNEERQPSFNNPKLVDNCKSTPIIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTD0</accession>
    <name>A0A914XTD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thyroglobulin type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTD0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10225.t1">
        <property type="protein sequence ID" value="PSU_v2.g10225.t1"/>
        <property type="gene ID" value="PSU_v2.g10225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thyroglobulin type-1" evidence="4">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10225.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19959" checksum="5DA636A8E54F73B4" modified="2023-02-22" version="1">MRLCKSDLDCLFDDEVCSLGKCCSSCIARRRQILREHPQEALVGYHVPECSEDGRFYQLKQCIHGFPGECFCVSLYGQRSNPSGISGREIVCGNSIDDNLNKPPPKSPYPEEPPPRMDPFSAAPTRTTEAQAQSDHFLTLGKNGFGGNGKFIFDRKKTRSIVWLQNFSKKPTLDLENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUF9</accession>
    <name>A0A914XUF9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dual specificity phosphatase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUF9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11588.t1">
        <property type="protein sequence ID" value="PSU_v2.g11588.t1"/>
        <property type="gene ID" value="PSU_v2.g11588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF3">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dual specificity phosphatase catalytic" evidence="4">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11588.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11406" checksum="61B21DF097BB5E8E" modified="2023-02-22" version="1">MFPKPPSKKLAGIESSKSKIFSICKIRPYLYIAGCGDLSHRKIKELGITHAVDATNISKTQRTPDVEYFEVKIDDDERADIKKYFIEAAAFIQKAKDSVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUP3</accession>
    <name>A0A914XUP3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10968.t1">
        <property type="protein sequence ID" value="PSU_v2.g10968.t1"/>
        <property type="gene ID" value="PSU_v2.g10968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057493">
        <property type="entry name" value="PH_RdRP-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25359">
        <property type="entry name" value="PH_met_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH-like" evidence="1">
        <location>
            <begin position="121"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10968.t1"/>
        </source>
    </evidence>
    <sequence length="380" mass="44377" checksum="9FC647CF4FB73FBC" modified="2023-02-22" version="1">MSTIYCRLIFHDFPEIYINEFVKLAHEFQYRTVHQLIIEPAVSLDSDSFEKKTEVPFSFELKAAAEGRRLGKTERYQKICLALAELSTAVESFRGHCFHYGLSKSATAIMTILSRNIYPQFFNLQNVFSMEKLAFGSINNRRIFAPTFIFDEPTNERNEDQIFKQYLDEQRGLQDIGSNMLICFEHDREMLTVCFPDVFRNGRSDNNNDSSLNRIIDIRVSYSAIRRLIVTMSTDESGEIKVSFTFQLAYPPTIYVCQMSTGGVGEYNTKFKQPIRFLTWNQGYDIQRSVAHGSCLVADCRFVDARTLLDCLDRLRKINNCAIEFRALFRERCVNIKNYERNRFMHPDDLPSEYAKLKEQKYFPFDLCGSSVDFSRWFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV09</accession>
    <name>A0A914XV09_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XV09"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10377.t1">
        <property type="protein sequence ID" value="PSU_v2.g10377.t1"/>
        <property type="gene ID" value="PSU_v2.g10377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10377.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8397" checksum="3C0268E06C669A4F" modified="2023-02-22" version="1">MILTNISQWLQTPIFAQSDIPVWFLTVWSSAINPICTMLLMGSYRKVIFNIFGSTSTASKVSAIPKQTFINAISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW68</accession>
    <name>A0A914XW68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XW68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10777.t1">
        <property type="protein sequence ID" value="PSU_v2.g10777.t1"/>
        <property type="gene ID" value="PSU_v2.g10777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10777.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31697" checksum="EA2A86BB33A4D61F" modified="2023-02-22" version="1">MAEFVQRHLEELLPAFTGLQRTKILSDEEVKTLIQKVRQFEYSVNKRTKRPKDFLKYAEYLNDLIELINIRRQALGNKNKRNEIEKPLKSHAAHLLRICSERFKKAEYYHKEIEFLDNNALYHILTKTYTRFLRLHGTNPRNHEEAGRWEFFKNKSAENARVIFQFAVRKFPKDIGLWVAFVEMEIAYVVMLAERRARLTSSDGKAKEDENETLIALDDGVSDEVFQFKLVEIVLNQGLENVDDKNGFKDICREKIKQYNVESPVLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXQ3</accession>
    <name>A0A914XXQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11308.t1">
        <property type="protein sequence ID" value="PSU_v2.g11308.t1"/>
        <property type="gene ID" value="PSU_v2.g11308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11308.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="35250" checksum="287F31B56119F45B" modified="2023-02-22" version="1">MILRLLHINIININIYIITQQLLRGHSRSRSPSPGDNNGTPRSGRAVAGGTVYDSEVRYPSYFGHYPSSKPGPYRHIGQAPGDQYQMAHFATNPSGHSSYRTPPNSATTSTGQPNSSRRPRQQPNITEYPPSGALFDPDSSDPPSGYLTTRSGRYPSTPRSTYRSASQHPEYSDEDEDDDEPSESEPMTQRSSGGNYAPPNSANNTRRLPLIGQTMSLGYGGTRSHNDPALTQPPLPQRRPRPMSDNFSSSQPPPQTSTTRYGHIPPSPTPRSPAELHMYSDPSYPSAIPSTSGSNPQPSGNYSTHSLPPVAAPYGPTGAPRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXW8</accession>
    <name>A0A914XXW8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXW8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12046.t1">
        <property type="protein sequence ID" value="PSU_v2.g12046.t1"/>
        <property type="gene ID" value="PSU_v2.g12046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="62"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12046.t1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33738" checksum="216059BAFCEC437B" modified="2023-02-22" version="1">MVEPKQEVIETPVEHPYYNQEQDEEDVVVDDVVDDSNNGYEQEGELEEVYEDEEQSNFNNPRSQRSLSHLTEQFIKYLQSKPAGLVDLNLCAEELKVTQKRRIYDITNVLEGIGLISKKNKNIIHWKGGQLRKPGGGIELKPGEGEKMYKLKSELTELEREERLLDTHIKWLKQCATNLAEESDNYKYSYLTLNDVTTIFPENQTIILQAPKGTKLVVPNVTHDGTYKLQAVGTSGPVAASVIQHGGMHLFQDPASGAEIEMMIEPKSIELEPPPHTDYYLVSGKESEVPLLHELYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXZ8</accession>
    <name>A0A914XXZ8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914XXZ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10595.t1">
        <property type="protein sequence ID" value="PSU_v2.g10595.t1"/>
        <property type="gene ID" value="PSU_v2.g10595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="113"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10595.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35029" checksum="CB3F54CC6E1ECB08" modified="2023-02-22" version="1">MIDPEVVAKRMLLNGPHRYNIPAEFILTLIDRVEPLFRREPTLIRLHSPIFAVGDLHGQYSDLLRVFKRCGLPFSGEKFLFLGDIVDRGKHSLECLVLLLCLKAKFPKHILIIRGNHEIPSVNKTYGFYGELRQRYARTGEWQLIYDRINRLFSYLPLSALINSKILCLHGGLSPELTSLSQIEAIRRPLYEPSGLAECLLWSDPDSECNGFATNKSRGVAYIFGKDAVVEKCKKLGVEKIIRGHQLVDYGFDTFADGKVITIFTASSYHETINNYGGIAAIDRNGNIEILQLSPQYPMTDDETSDPIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZA4</accession>
    <name>A0A914XZA4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1186.t1">
        <property type="protein sequence ID" value="PSU_v2.g1186.t1"/>
        <property type="gene ID" value="PSU_v2.g1186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16226">
        <property type="entry name" value="EFh_CREC_Calumenin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000090">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038007943" description="Reticulocalbin-3" evidence="12">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="262"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1186.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36564" checksum="4D5D70AEFBDE82BB" modified="2023-02-22" version="1">MRNTIILALCLGVYLVSANHPEALSDKDHFKGNEHDNKFDHEAFLGKDTAAEYDQLTPEKSKERLAKLVPKMDINGDGFVEENELREHINFMQKRYVNNDVERTWKNYKDEKIKDGKLGWKDYREMVYGSTDGEGQELSPEYSKMITRDERRWKVADYDSNGMLDRTEYGCFMHPEDCDHMRDIVVQETVEDIDKDKDGFVSLEEYIGDMYRPEDYPELNGKEPDWVGSEREMFQEHRDKDADGKLNKDEMRDWIMPVGFDHADAEAKHLVGIADDDKDGKLSPEEIITHYDTFVGSQATDYGEQLQKHDPAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0F0</accession>
    <name>A0A914Y0F0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0F0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12941.t1">
        <property type="protein sequence ID" value="PSU_v2.g12941.t1"/>
        <property type="gene ID" value="PSU_v2.g12941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12941.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19141" checksum="1C1BA8F312D4D52B" modified="2023-02-22" version="1">MSSNLLSYKCHFKFTYRKLVIYFENDEISYVTFESCYGSNVHGKCIHSATYKRFSDMSFEANFCLMEVYIAVANALSVQSIYTFKNYGIEGLTIRFMANKKIHCEFDDQFILCTNDGQVLVASDAQDKMPEFELLKNILADLSKMSENFEKTSNKKFTITFTEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1Y1</accession>
    <name>A0A914Y1Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1Y1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13240.t1">
        <property type="protein sequence ID" value="PSU_v2.g13240.t1"/>
        <property type="gene ID" value="PSU_v2.g13240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037276682" evidence="1">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13240.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11986" checksum="3D7CAD9EAE2F4915" modified="2023-02-22" version="1">MAWKHTFVNLILFLFVVNLVNDVVLSASCNSNEYCPLGWSVKRKNDSSTQTCVPHSETDKCPKPYMCVASKCGINFCCISDKMLARLEEMEDEKEEPDDEENEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2V5</accession>
    <name>A0A914Y2V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14511.t1">
        <property type="protein sequence ID" value="PSU_v2.g14511.t1"/>
        <property type="gene ID" value="PSU_v2.g14511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14511.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29691" checksum="9AB267307BDCDAF7" modified="2023-02-22" version="1">MVYQYFVNNPQQPSIDKEEELQICDECDQLFCNSYDYMITFEDESSTTIKSITKLKTKKPCLPVVAKAVEKSDKKDGIKCPVITFYDNLSFISVYNEDSGEYEALEEWNGDEGAQLFISFDEEKPKYCDEAAEVYDIKPSFVVYDLVKIMSIPPKNLKAERSHWCFRITKDDKNPVLIEFDNFDGTKKAASPEFLMALLLKQHLKVITAKLGTKQKHLSYAFPDLTDKEYNRVIGSLHKASKLINVKVVPFSRKKCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y395</accession>
    <name>A0A914Y395_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y395"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12241.t1">
        <property type="protein sequence ID" value="PSU_v2.g12241.t1"/>
        <property type="gene ID" value="PSU_v2.g12241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12241.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26252" checksum="63524067CC601B2D" modified="2023-02-22" version="1">MKVPKKRQKLDESVESEESVKIYVANKIFVQKGLKILANYRKLIQDDFGSELEEVNFEENFASIEKINKFVKNSTKDMITEILSPNDINAQTKAAIINAIYFNGLWEKPFDGREKETFYSNPKREIDFMTTRPENGDWNFQKGINWRALGIPYRNRKTWIQKSKSLGVTIPLIEVSTTLDLPENLNKLGIIDAFDERCNLSKMFLVGEEPTFIGKAIHKAAIKVSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4A9</accession>
    <name>A0A914Y4A9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4A9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12576.t1">
        <property type="protein sequence ID" value="PSU_v2.g12576.t1"/>
        <property type="gene ID" value="PSU_v2.g12576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12576.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16009" checksum="C5BEC022EEECDB65" modified="2023-02-22" version="1">MLRCCNNISILSVRYTHPSRLKPEIIRCLPSDQSPVIYRDHVVDKLIRVILKDGKKEIARTAVYDALEIIKRRQYRQWLKAATEDEKNKIELNPFTIANTAIRNCRPLMKLQGVTRGGTTYQSYENDARNLSSKSTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4B1</accession>
    <name>A0A914Y4B1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4B1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13611.t1">
        <property type="protein sequence ID" value="PSU_v2.g13611.t1"/>
        <property type="gene ID" value="PSU_v2.g13611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding" evidence="7">
        <location>
            <begin position="62"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13611.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32153" checksum="39B2252D1B204168" modified="2023-02-22" version="1">MAHHHESKGPVGPAPLPHQVVYTTLHYDTPWSYESYLKTGGYAALRKILEEKIPPEQVIEMVKASGLRGRGGAGFPTGLKWSFMPKGNMQKYILCNSDESEPGTCKDRDILRYNPHSVVEGMAIACYATGSTVGYNYLRGEFHHEPFEHFEQALADAYANGWLGKNILGSGVDIDIYGALGAGAYICGEETALMESLEGKKGQPRYKPPFPANFGLYGKPSTINNTETYGSVPADHPQRSGVVQGPEPDRQRRSEVLLGVKAACRMAATSKCRWAPNSTTCWKWPVACVRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4E2</accession>
    <name>A0A914Y4E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4E2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14307.t1">
        <property type="protein sequence ID" value="PSU_v2.g14307.t1"/>
        <property type="gene ID" value="PSU_v2.g14307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14307.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="9711" checksum="320650FC9D06F4D1" modified="2023-02-22" version="1">MLLVIRHTGDEAGSGAFALLSASADIVVAGSSMIVVGDAPMDGGADVSSMNDVGLCNKSWQWCLCITVSFVGHGAAASMTDCGRAPMDGRAAACFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y572</accession>
    <name>A0A914Y572_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y572"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12846.t1">
        <property type="protein sequence ID" value="PSU_v2.g12846.t1"/>
        <property type="gene ID" value="PSU_v2.g12846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12846.t1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45864" checksum="DE3247611F474902" modified="2023-02-22" version="1">MAATNRIFIVEIRDMLFNLNTCIRIHNINTGKMLKKELNYSLIIKEQEKFFSSLPSLIQLHRVKAFVFHLFEFDDILPSKSYAFRLRCVEFCKENGIFCFFTDEVLLCPLAAILHTKTIVDEGQGILVIRPMGHGTNAFMATKLIREKDRYYILDCAPHITVEEYRDIFMDDFVPKKVFIFNETRVRESPDNILFKLKNYFNDAIFLSDDKEKLYTDAMFTKVLHLLGEKISPYDIAVAYVDIFDIRLDSRKTLFKVERFSILPYEKSVVIDTSAAKSVSLFQETTEVPPECLKEIPFASIKSKKLKITLKIDYNSIPEFTVEEESIKKEFPSNPEKARFVFSKQYFSVKIYDENEKEYVLEDSEGLDKTPIYISFTEKKPIIGKSAMEAYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5G2</accession>
    <name>A0A914Y5G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5G2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15440.t1">
        <property type="protein sequence ID" value="PSU_v2.g15440.t1"/>
        <property type="gene ID" value="PSU_v2.g15440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15440.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7817" checksum="013BAF1307981D97" modified="2023-02-22" version="1">MIRNLYRHVQPLTAQIASSSPDSLGIFEDFYEEVFKEIDEAYGRINQMHVCENMGEHLIGNVYIKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5S1</accession>
    <name>A0A914Y5S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5S1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14114.t1">
        <property type="protein sequence ID" value="PSU_v2.g14114.t1"/>
        <property type="gene ID" value="PSU_v2.g14114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14114.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10679" checksum="3B83C7F70CBA77FC" modified="2023-02-22" version="1">MMGTDISSGNYAVMLMAQITSIQDPAQAVTAVRNLASRNADIYVIDESHSALPSNLWGILTQNQPYHVINGTVMTDIDELFITFDATLLQDFSNMHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6K4</accession>
    <name>A0A914Y6K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6K4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15821.t1">
        <property type="protein sequence ID" value="PSU_v2.g15821.t1"/>
        <property type="gene ID" value="PSU_v2.g15821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15821.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26674" checksum="4CDA673DD94F1FD2" modified="2023-02-22" version="1">MNVGTARNQYLPPHGGNRNRAANIPETIRQFNKSIDPSNSEVNRVYPTSSDHYLNGLGLVTKYYYNIIDWSPKNFIAVALLEKVFIINVATTGADLFKDFNSNTYVVTSLKFSKDGALLAVGFENGFMHIFTVDTKQLVRKFNAEVRGIGSVAWTSGGLLSYGNCNGRIQTHDTRQHVSLLSETRHHGNKVCALNWVCNDKYLVSGSSDYIVNVYSKDTIIRQDPVCFYLLFIAVTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6Q2</accession>
    <name>A0A914Y6Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6Q2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15880.t1">
        <property type="protein sequence ID" value="PSU_v2.g15880.t1"/>
        <property type="gene ID" value="PSU_v2.g15880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15880.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21884" checksum="A71899A3DBF6A961" modified="2023-02-22" version="1">MRSRQMFVIDFGVARKSNPSREPFELRKTSFIGTARYASLMSQQGIDDGKLGDLWSIYFSTIENILGQLPWRFEENRSKIIEQKQKLQDLAISKTIVQHPWFSPPHHHPHHLGPPPSILYFLHILQTDDSAGENIDCASLSGALVNLHFYVYDLNMLGIENRSLDWEGKFCDDHISGEYWNNPYFNKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6R1</accession>
    <name>A0A914Y6R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6R1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13329.t1">
        <property type="protein sequence ID" value="PSU_v2.g13329.t1"/>
        <property type="gene ID" value="PSU_v2.g13329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="60"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="2">
        <location>
            <begin position="249"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13329.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45807" checksum="1845DDB0AE4B6CF0" modified="2023-02-22" version="1">MNYLEIRLDEFGSEELFKGKENSCILNPEKLADLRELYQNVRTRVEDAKQFMKSSEEKPILTKLIEILRSEKPTSRIIVFVDMRKVGSDLSKYLNTRPEIIELFGRNKVGYIASTNQASSRFGQTQAEQQLMLEKFKDGSINILVATSVAEEGLDVAACNMVLKYNSVGSEKSLTQRKGRARAKGSKAILLALEEKTMRREFENVRKEVLMNICIQALQVMSEHELTRRIKEKFEEMKAIAVEDKRRDEECKNYRNQIYELCCKECSRVFCKSDEIFSLNNNEYICCNRECWNDTKIKRRIGQKEKGNMVTIQCGEWLCYCGHRRGNVIKYGGTYLPTISSASFTIKLFDGPHETFPTKNTSWDWLKQHKFNVSPITTKELHEMAASLFNLQPTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y714</accession>
    <name>A0A914Y714_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y714"/>
    <dbReference type="WBParaSite" id="PSU_v2.g160.t1">
        <property type="protein sequence ID" value="PSU_v2.g160.t1"/>
        <property type="gene ID" value="PSU_v2.g160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037688910" evidence="12">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g160.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28508" checksum="FB7C03818114BD5F" modified="2023-02-22" version="1">MLLMLGLGSMFGTLEGVITSLNDSHVITVKKPVLTAVLCGTACVIGLLFTTRAGQYWVSLFDHFAGSYALMCIAFFEIIAVIYVYGYRRFLNDLEYMTTERPGRYWTITWRFVSPVIMVVLFFSSIIKSFTHHPVYSAYDPITTAQVDTEYPAWALFVALMLVSLALAPTPFIYFVRKFKIWKIEGDIPAASKCLGSTPSTTYMLKSEPSFNRMVESTASELQAVGINGPSTNGTTKNVDNDRKGNGSSRHAPKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y790</accession>
    <name>A0A914Y790_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y790"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16075.t1">
        <property type="protein sequence ID" value="PSU_v2.g16075.t1"/>
        <property type="gene ID" value="PSU_v2.g16075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033202">
        <property type="term" value="C:DNA helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="118"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16075.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36046" checksum="7DC8B65E25ADDAD0" modified="2023-02-22" version="1">MRQAYIEYQARCDRAGLVDFAELLLRAHELLRDNPALLAHYRARFREILVDEFQDTNAIQYAFVRVLAGDSGHVFVVGDDDQAIYGWRGAKVENVQGFLRDFPGAQTIRLEQNYRSTANILGAANAVIAHNPDRIGKQLWTDSGDGEPIDLYAAYNEMDEARYIVERARQWVRDGGSYTEVAVLYRSNAQSRALEEALLSEQVPYRVYGGMRFFERAEIKDALAYLRLLSNRNDDAAFERAVNTPTRGIGDRTLDEVRREARAQGISLWEATMLVTQGSALAARADPAHDPGRARGPRAGPLAAARALEQGKPQRAGLRIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8K0</accession>
    <name>A0A914Y8K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8K0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15775.t1">
        <property type="protein sequence ID" value="PSU_v2.g15775.t1"/>
        <property type="gene ID" value="PSU_v2.g15775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="387"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15775.t1"/>
        </source>
    </evidence>
    <sequence length="584" mass="67061" checksum="FCE43DBF77567FA5" modified="2023-02-22" version="1">MVEFQDAEYCYKNDCSGADINSTGFIATTIRPFLKSFSSGFRSFMPYPLSEFDDTGAFVFVFFIISTIMYIISWLFSDSGRPDVLDRRALHDSLTKIKEQEVQIEQLKRNASDPAVTAQYGKEIERLRKEKSEIENRLHAMGQAIEQRESESHEAHQEQKRLQNENHQLVADKAELQNKFDNVFTENQDLAKELSLVRSQLAEANERQSNSVAENQENRRLINKLESDINELQSKNSSLQIELDTLTTKCEQLERQNENLKMSESGCMDLIRELEEKLKTSDAKITKMFKKDGIDETGSGESNASNGWSDMEMGDLEASEDVKEEEAKATTESEAIKPAKPTKPVKVVTLGKKDSKATKEKEPSPEQLRKASISGKARASSIDIYEVVNLKSELRRLEAEREDLKRELENEQRNRESVNDQLDQLKKTLAEKKSDLEQTAKDKDYFRTQTETLSQRVAEYTQKIERLQEDREKVFVLEKDILVLSKEKEEAYSKIKDLEKAVRKAEEQSTKLETRYFHEERRLKEQMYKLEEQLTKAKISTIALENAGSGNSSDRGDFLLANRNNVDVPSLWSDLDGPETSFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8S0</accession>
    <name>A0A914Y8S0_9BILA</name>
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        <submittedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8S0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15852.t1">
        <property type="protein sequence ID" value="PSU_v2.g15852.t1"/>
        <property type="gene ID" value="PSU_v2.g15852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF7">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15852.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24216" checksum="305AC0CEBD1CEE5F" modified="2023-02-22" version="1">MLKDRNGAVNILMDGQYDSPGYCAMMCKVTAIDAKSGYAVGIQTLQRTMTENKSARMEIEGVRRIMKEMENNGVHVDRATTDRNTGVIALFREEFPKTQHKNDTWHMVKGVKKDLMNESKKKRSQDLAAYVPLIKNHFWYSVEKANGDGEMCREILLSGLFHLIGIHKWKKGKICKQLKMYILRIIGKDDESYNQFLKKNPDNCSKFFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8Z7</accession>
    <name>A0A914Y8Z7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8Z7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15743.t1">
        <property type="protein sequence ID" value="PSU_v2.g15743.t1"/>
        <property type="gene ID" value="PSU_v2.g15743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15743.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="21841" checksum="30C5364D12C4D98F" modified="2023-02-22" version="1">MKRRINYGKPKYPLEALKSPGIKVHHAKTPSTPKSAPSTIKSPKSPSTLADSSRQHSPDESHFGIIDINPGHLPKYIGDSGRINPGFSGDTPLQTPTGLVRRTPSGRKPPASPLSTTSYPESNHFSFPPQLKFPTSHSNHSMGSGSSGVFPTSMAPGAIVLDKPPAGRGIHKPPPPPPSGTMTRKKPPPPPPPCEPSSCKCDFEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9S8</accession>
    <name>A0A914Y9S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9S8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16190.t1">
        <property type="protein sequence ID" value="PSU_v2.g16190.t1"/>
        <property type="gene ID" value="PSU_v2.g16190"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16190.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17205" checksum="87C16E4E7D3E23D6" modified="2023-02-22" version="1">MPLHRIYHTPGQFSKDQKKDLADAITKIYTNPNGAGLPAFYVVVIFIPIEENNFYVGGETTKNFVRISIQHIARNFDSHEQAKGFLNRYENALAPFIKERGFDWEVEIEQIDRNLWRENGLSPPLPRTDAEKEWGYKLKQKQFHIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBE4</accession>
    <name>A0A914YBE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14808.t1">
        <property type="protein sequence ID" value="PSU_v2.g14808.t1"/>
        <property type="gene ID" value="PSU_v2.g14808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14808.t1"/>
        </source>
    </evidence>
    <sequence length="671" mass="73398" checksum="4949A406FD9A1ED6" modified="2023-02-22" version="1">MEAMRTYTATAQSTASSPIINSTPVTTTNAVATNPLLSHALNTAGIIKNNKNHQATTSSTSLESIINRKRSADEEIIQIDDDQPMPRRHCPNANNQCSGDFSKPLTNITSSTPTVATPSKVSTPSSLPLPLSSYSRTPSSFPLENSNTPAAVEGHRYVTLPTIPPISILVPNDIKIMDKLDEIINSAPSNFNPSTINLNGQTNSAIQEVSAGLMPSTKQISTSVPSQLLLEGLRHQKPHDSRMFKDSFCSDSVTAPSQLNNPISTNSTFNQMFPQNLNNNDNNSNIINFDNNQLLNVVPPPQWIQLIQQPQHNPPQFQKSSLLQQQIQAASSPHNFQQSFQSLQNNQPFLPTITNQPQLRFSVQPLPPTSNAGLSALLSQNNPTNYFKSINENQQNSMTPSLPINTSVGIQILNQPQQNKSESASNLSNNNLINFANFTLPTLTPPQPPFILQAQFQQPQKPQIPDVQQQQQQQLNSKQITIQQQQSTTSRNLFEQIQQQQQRLVPPKTPNSQPQLPPMSRSVQTPTSQSNSSSLNSITKMNFPIEQQPFAQYLLNLPSMSPSGSTSNTTPQLPSVQQSPSDVSTENGSTSSFTPNITEQLFTSTTMSSHFDTSNLKHSPTDQIASSFIDGDGTAENKKTMTVGSVVAPTYLDVLQSNMIILSSTGQQMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBK3</accession>
    <name>A0A914YBK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14869.t1">
        <property type="protein sequence ID" value="PSU_v2.g14869.t1"/>
        <property type="gene ID" value="PSU_v2.g14869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14869.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10343" checksum="769DC2AD5FCE01A1" modified="2023-02-22" version="1">MLKIFLKAVEMALSKKASSVCDEITFRSTNYMSYTDAPFIDGDFLRELLAYSNPDEIMEGIVIPKSLESENPGLSPGYIAFNYLRQLWSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCF9</accession>
    <name>A0A914YCF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCF9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17923.t1">
        <property type="protein sequence ID" value="PSU_v2.g17923.t1"/>
        <property type="gene ID" value="PSU_v2.g17923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="372"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17923.t1"/>
        </source>
    </evidence>
    <sequence length="589" mass="68759" checksum="8D37056266B4F6C1" modified="2023-02-22" version="1">MFCPPWKVLVEETSNKIKENYGKILFQKPQNFVALFFQQCPLNEMRMATMELITKTHKLITSIKDGDSANQIQKILLNFDEWMDVTSDEAVKEAMSATVSQHTWDNCFKIVVYQKLSKKIAVLDLLFCIRSPESEKRKALINAGVRKLLDKEATFRNGIDWIKTFELNNLKEAQFDNIVYKSIIYGYEKLLKRTLEKFDEKLRCVRLIDQCLKRAETDILENQSQKDLVDFITIKKLPAFIGKISNSYGINAEKYKLYACRALFIEKTQLIYSSFDRYYFELYALEALKGRTVENKLDFLYVISDDLQYACCWAKYLKLSTKSMPPFLPNCEQFDADAELFIEKITKTPLTSEDEDCIVDRKFWGKSYKLITIATPEALNNFIDEYFIKSKPKIMGIDCEAGFPVNNNEKQKIAVLQLATSDWCCLIDIQLLSDKLSENQWRNIFEHFFHPDILRIGFMFQCDYYFLCSRFPNLQKFFEQKERKVLCLQKLTDSTINCDGIFKTKLHICCGLADLAKEILNIDLDKSLQNSDWSKRPLKTFQKLYAISDALIVVLIHEKMEPLLKEKLGETVAAEMFEKSYVCNKKYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCJ4</accession>
    <name>A0A914YCJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17019.t1">
        <property type="protein sequence ID" value="PSU_v2.g17019.t1"/>
        <property type="gene ID" value="PSU_v2.g17019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17019.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17656" checksum="82EBC03E9A2E20D3" modified="2023-02-22" version="1">MEKFGGKPITIVKAEDSDAPGPQSEIRYAIVQDSSTNAWKYFRVDEITGGIYPLDKFDREAQDSFIFDVEAMDSMQSSLPGATGTNKDIVKVQIFIGDINDNPPYFTEKRYEGRVKENAEIYTDIITVKAQDLDRRKLNLNLIKIAKSKLSKLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCL1</accession>
    <name>A0A914YCL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small-subunit processome Utp12 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17032.t1">
        <property type="protein sequence ID" value="PSU_v2.g17032.t1"/>
        <property type="gene ID" value="PSU_v2.g17032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17032.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17627" checksum="15C6EFEB24E2AFED" modified="2023-02-22" version="1">MPQKPTTRSRQSSTGSNRSQTRQKNDSESNSIKDDITASLKSNDVLPTSNGAVDKSEAFKDLVTESKMATSGGTSFVVLLSQGIVGNDEEKIESVVKNSDPATVLATVKNLPVIHVIPFLNILEQTFRRDKVKQPHVWMNWVQAVLSIHMGYLSSVCLSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCM6</accession>
    <name>A0A914YCM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17181.t1">
        <property type="protein sequence ID" value="PSU_v2.g17181.t1"/>
        <property type="gene ID" value="PSU_v2.g17181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17181.t1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39161" checksum="590A44B8A50586F6" modified="2023-02-22" version="1">MSKEIASDIKNAITDVFGSFEDFQRIQKRSDSNHCPFLTPSKYSDPNGKLKKMAETIKVNKERQKHEVEKIKKSVEEKQRFEKEKNDYNIWFEKRKSHQSRHSTPFMEPPPKVSQKVLDMYALKDREMLAQSLLPPPLLPLDVVMRNGDSSDIPSSSSASTSLLPSSSSKRPHSKERKSSHREKERHERNHHHIPKESKQTFEPLPMPTLVKEEPKTEIKESPKNEFGDLSPVEEAALRDEKAITEIAISSSTTTTTVTQNESAAKQRNLMSDLFGDDEEFEKLEPSLSSSSRATSQAPEPKESLPCIKEEIIQTFNSTSFFFLCYHNNYFNNDNNVTIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD81</accession>
    <name>A0A914YD81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD81"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16701.t1">
        <property type="protein sequence ID" value="PSU_v2.g16701.t1"/>
        <property type="gene ID" value="PSU_v2.g16701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16701.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37652" checksum="4122A054E55FF7CA" modified="2023-02-22" version="1">MAVCFFVFIFLIIFYYSFRYFRETQILSNLNKRVIFITGCDTGFGRLLAIKCVKAGIPTFAGCLTSDGAKSLEKEIGETELLKTVIVDITSDESVKNALKFVKENIKSQRKLWAIINNAGILIYEGPSEWIGVESYKKIAEVNTYGVIRAFLPLLRESKGRIITITSCAGRIGFPLIPSYAVSKFATEAYMDCLRRDVYDFGITCHILETGRFKTDLVNAENRYPKSKQAWDALPQEIKDIYGKDYLEKVDKTFYDILEKESSARVDFVVDAYFHAITAKFPRLRYIIGYDANFLIIPICFVPTAIQDWILRFVARIPIPDSVKQSIKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDE3</accession>
    <name>A0A914YDE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17317.t1">
        <property type="protein sequence ID" value="PSU_v2.g17317.t1"/>
        <property type="gene ID" value="PSU_v2.g17317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17317.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24928" checksum="ACCCC6B3761A54B2" modified="2023-02-22" version="1">MIENVNVFARVRSLSGEESCLQIHHELSRITVNDKAYYLDDVFGETASQEDVFDIVGRPIIDGFIEGINGTIFAYGQTGSGKTYTMLGPDINGTELNNAGIIPQAVDQIFDTLKGKFEQDPVFFKFSMKCTFLEIYNDEIYDLLRNEDIFSKKLEIRVCAGDVKNVEEKDVTSYSECMELLKRGIKKRKNAETAMNSESSRSHAIFMLKLSTEEIEGDNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDQ1</accession>
    <name>A0A914YDQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-hydroxyoctadecanoyl-CoA = heptadecanal + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:55196"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:74116"/>
            <dbReference type="ChEBI" id="CHEBI:138631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55197"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDQ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16883.t1">
        <property type="protein sequence ID" value="PSU_v2.g16883.t1"/>
        <property type="gene ID" value="PSU_v2.g16883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF142">
        <property type="entry name" value="ACETOLACTATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="6">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16883.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="27144" checksum="C1CEB7949F7C3E1F" modified="2023-02-22" version="1">MTLRGLGALPANHPQSLGMLGMHGTRAANMAVQESDLLLVLGARFDDRATGKLAEFAPFARVVHIDADAYEISKLRSADVAVPGNVGHAIRALRAAFPSPKAHQDAWRRRCAQHRDRFAARYDAPGQHIYAPALLKRLSELAPADAVIACDVGQHQMWVAQHCRFNHPRNHLTSGALGTMGFGLPAAMGAGDHRALPPAGEDRAAGQQFAGHGAAVAGAVLRRALQRNRPVRQPGLRGAGAGVRHCRDPHRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDR9</accession>
    <name>A0A914YDR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDR9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16902.t1">
        <property type="protein sequence ID" value="PSU_v2.g16902.t1"/>
        <property type="gene ID" value="PSU_v2.g16902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16902.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28111" checksum="EC16AA48A8E26E73" modified="2023-02-22" version="1">MLYDILPNTNPDTIVLQYTYFANIDKYIFITLRNGHSTHKNYHILRGSDIVADIAIRKFSTTLAVINGDKIILPKNIQWYLTYVETRKFVECNYESAEKVNLTAPRLVPHRAVELVTEFVDIFIENGQIPFLSFGTLLGWYRDCGIISHTHDIDFNVFATEYDPTIEKIFINNPEFTLKHRIGKREHSIEYTFTLHHKVPGYNATPVDIFYLYNHNETHEWSPFLSDFYQLIRGKSVLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEC6</accession>
    <name>A0A914YEC6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEC6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1765.t1">
        <property type="protein sequence ID" value="PSU_v2.g1765.t1"/>
        <property type="gene ID" value="PSU_v2.g1765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1765.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25401" checksum="711F0890E08FAC1A" modified="2023-02-22" version="1">MRTAEVIDRYISAQFPDPELYPNLFNLVSTHMIHGPCGPRCEKDGKCSKGFPKKFQEETSLDEDAYPTYARPDNGRCVTKSSGFVADNRYVVPHCPNLLLLMNCHINVEVVSSIKAVKYLYKYIFKGHDSAAIKIVDGVVHYDECESYLNSRYMGAAEACWRIFGFELHKQSHSISRLPLHLPNEQTINFTDAENIEDLQAAMDSKNKFLDCITLGHQFQLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGN0</accession>
    <name>A0A914YGN0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGN0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19467.t1">
        <property type="protein sequence ID" value="PSU_v2.g19467.t1"/>
        <property type="gene ID" value="PSU_v2.g19467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19467.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11294" checksum="B1B1AD21A7ADC35C" modified="2023-02-22" version="1">MVGAGFSLNAKKIEDSFNGMALWDDLKNELTKSLSHKGNLDNVDVLDIGQMYVKEYGRSHLDEALKDAIPDNNYEPDNLHFDLLRLPWSDVYTTIMTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH14</accession>
    <name>A0A914YH14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHK kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16599.t1">
        <property type="protein sequence ID" value="PSU_v2.g16599.t1"/>
        <property type="gene ID" value="PSU_v2.g16599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16599.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33223" checksum="01E1A2C85CF834BB" modified="2023-02-22" version="1">MPKIYATKEWIVGKEQGYILMDDLSEEGIVLSKYDSVSPGQIKAVVKEIAHIHAEYIKAGKGDKWKNVFGKNQEVWAGMTDEFLQLIPAFIDLVSNKEKVAKDLNKIIDLAGNKEYHLWVASEANKEIGLPSVLVHGDLWNSNVFFQNDSNREASTEVLAFIDWQLVCEGSPATDITRYLLLDADGVVRRGIEPIIFGFYINCLRSEIPSISFNETQMRKAYLCSFITQVLSLLIITVFNCKSLQHLISANEEIAINCAKKDKIILQAIHAIEDAAGFIENELADIAKRFQKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHV3</accession>
    <name>A0A914YHV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19063.t1">
        <property type="protein sequence ID" value="PSU_v2.g19063.t1"/>
        <property type="gene ID" value="PSU_v2.g19063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19063.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19999" checksum="D5F8C873CE75FA2E" modified="2023-02-22" version="1">MKGGKLKIHTAVPERTSLPVAEKTAPKNKFHRSYSVPPMNAQIATSSKVPQQKASISFEPKSTKHSSSTEHRPSINPSLHSRYDRDRKISTFSRTRSSIRSGSSCGSSMVYPSTAHYPIGYNPSYSSYNNAPCPPRPAHYGMAPFDMLLGHLLTGGQYHPLHPAYAAGTFMGPNRFMGGFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIE6</accession>
    <name>A0A914YIE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19274.t1">
        <property type="protein sequence ID" value="PSU_v2.g19274.t1"/>
        <property type="gene ID" value="PSU_v2.g19274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF84">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="49"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19274.t1"/>
        </source>
    </evidence>
    <sequence length="580" mass="63727" checksum="0708A82BA01EFB07" modified="2023-02-22" version="1">MQAHVGGQNSSEKLVTSKDQTSKEKEHSSQSVFCPPAPGALHDVFPLTLAWHNIHVAREKPSGVTILDNINGQALPNEVVALMGASGAGKTTLLNSLMGRNLKGLEVTGDIYVGGSKEVKIVDVSGYVQQEEMFMSTLTVYEHLSIQAGIRLSGLSKASINERLTEIMDELGLTKCKDSIIGLSGVKKGISGGEAKRLMVASVLLDNPSIIFLDEPTTGLDAHMAQSLMHSLQKLAKDGRTIVCTIHQPSTSIFNSLDKVIFLADGQLAYLGPPKTILPFFDSLHLVCPDDYNPADYIIDMLAIDRTNGQEDIALERIHKVCKGYTESPLTKKIYEEIKTFEGSGAENGIPDNRRRASFLSQIWLILKRSLIDNRRNPALARAKIFQKIIQGLFVGAVYWQIEYIDFIDVQNANGALFYLLAEGISYYMVNLAPGVGNFFVNIGIGILIEQSATAFGVMLSTICPSYAIALSITGPLLTILTLTGGLYANVAKIEPYIRWVQYCSWFKYGFEALTINHWHGMPTTNGTIGTINKTAVEILHEYSFEESNFGMDIGAMIGFILLFYFIGYIGLHVRVRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIR1</accession>
    <name>A0A914YIR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrator complex subunit 5 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19399.t1">
        <property type="protein sequence ID" value="PSU_v2.g19399.t1"/>
        <property type="gene ID" value="PSU_v2.g19399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029444">
        <property type="entry name" value="INTS5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14838">
        <property type="entry name" value="INTS5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037916705" evidence="1">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 5 C-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19399.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="31044" checksum="A24DEC590C3F679F" modified="2023-02-22" version="1">MRAHFFFITLQWLLTVPPEAPESNEIIFDAFALREAANSFIDALCSDKHLSSFYHMGDWYEEKFFLSDHVEITRKLDTIPICFNLMEIFAVSPYPTFFCLAPLITAQLAAIVNRCELTLYKNDAMTKAMLDKIEKVLRLISKAQILTNIMPLIFEVIRRGTMHECSSILIELWRILTLIRPMEEKNLNDLMSELDLQMHESPRGIVQMPECPSFQLLKIMNLIVQRNAEKMSDLGFMIISLFPQEPEEDAWEQGPLFPVIAVNDPLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKW2</accession>
    <name>A0A914YKW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17966.t1">
        <property type="protein sequence ID" value="PSU_v2.g17966.t1"/>
        <property type="gene ID" value="PSU_v2.g17966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17966.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24668" checksum="5810668342FF5B60" modified="2023-02-22" version="1">MEMEPRNMTNSTLGHVHHLWGRFLSESRGVRLHGVFNHNLVLQIVAALGDLTENLDMSHFEFLNRFGRIRSFIIQAPLLRSFLFDSRSTDNPNLLTTMKWLEHCYVRQANFDTLLIVSDDIPNIQHMGFMINNRVMPITHDDSDITFINDVIFDDGVAAMMNHFQMHRYGDTEYHLPGAQYETRAYVMFAGLVKGRHFTFLFLVNEAVDFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLH1</accession>
    <name>A0A914YLH1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLH1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18171.t1">
        <property type="protein sequence ID" value="PSU_v2.g18171.t1"/>
        <property type="gene ID" value="PSU_v2.g18171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18171.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="18702" checksum="03A02F2C4E531FAC" modified="2023-02-22" version="1">MNIIKMSEHFGNGSFKAAVRLKSDSPITDEIFEVVVDFASESSVGVVVGKDSEVDFTVVGSDVDDNSVVEDIFVGASEVVVNPGFIVFTEEFTDTEDVVDFIVVVDSEVIADPEVVVVVVGFVEFVVDAKVVVVDSKVVGIGVVVGTYPISNNVEKSSPKTNLKSNDNILQLPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM60</accession>
    <name>A0A914YM60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21420.t1">
        <property type="protein sequence ID" value="PSU_v2.g21420.t1"/>
        <property type="gene ID" value="PSU_v2.g21420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036781616" evidence="2">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="175"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21420.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32993" checksum="6C8A0017DE792736" modified="2023-02-22" version="1">MFLIFAFFVSAAIFAKSQGYCPPPSVEWQSHCFYFEDESASFPNAEIVCNGMSGHLASIHDGFTNAILAGQAVNFFKNNSESDFWVGGTTLIAAGNWTWTDGTNLDFKDWDPSTKPNATSSSCISVKTNNGLWSSGDCFQTKPYACMVSSSIYIPPSTAVPVFMNCTHGWTYFEPSHSCYGIDSSHQAQWNNAEQYCQDLGGHLPSIHSVEEENFLQTYVFAFNQRLWLGLYSNDSEKTYQWSDNSTVNYIQWAKGNPTLKQNSCTSLDTTGFVDDYCYTNMYYICKKDALTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMH0</accession>
    <name>A0A914YMH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18520.t1">
        <property type="protein sequence ID" value="PSU_v2.g18520.t1"/>
        <property type="gene ID" value="PSU_v2.g18520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037885909" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18520.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8940" checksum="249EC02EFD35F01C" modified="2023-02-22" version="1">MKNILCIFFIAFLAVSNAYTPTLWQAYRELSPFLLPDSDALSSYCSAIMEENSIFSTNNSTRFSTMIPSYFRRFMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNG7</accession>
    <name>A0A914YNG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNG7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20954.t1">
        <property type="protein sequence ID" value="PSU_v2.g20954.t1"/>
        <property type="gene ID" value="PSU_v2.g20954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20954.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18957" checksum="185D3DAFF0678D9E" modified="2023-02-22" version="1">MSLHTGIRPSTSSSARLSVSDSSVLSQQQSHKPLSFRTIPSGRRPLTRTDSDASISSSHHKPSTLRLSRTPSTRSNSNSSVSSNRRMPTTQAPLRPSLSSPNIPFQISLNLVMKVQPIDEKYSMEPIGLRLNDVNILPPKTVRQQPFQQRQRSFSHNLYVDQLFQTHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP14</accession>
    <name>A0A914YP14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21361.t1">
        <property type="protein sequence ID" value="PSU_v2.g21361.t1"/>
        <property type="gene ID" value="PSU_v2.g21361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029827">
        <property type="entry name" value="JDP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21361.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17074" checksum="7A5F87F6B201A3F8" modified="2023-02-22" version="1">MFWYFQMQTLYEILGCNSSATVDQILAEYRARVIGAHPDKIFDENEKAEAQKRFHMLQYAKEILCDPSKRKHYDTYLAMGSRMPLKEWMNNQDKLQQTLHWASPSQAQPMLESSEPPQRMNPSATKIGGWVRHESATLSAFRNYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRJ5</accession>
    <name>A0A914YRJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AdoMet activation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRJ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2630.t1">
        <property type="protein sequence ID" value="PSU_v2.g2630.t1"/>
        <property type="gene ID" value="PSU_v2.g2630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="entry name" value="Vitamin B12-dependent methionine synthase, activation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050554">
        <property type="entry name" value="Met_Synthase/Corrinoid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="Methionine synthase activation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AdoMet activation" evidence="4">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2630.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16914" checksum="55DAD4CF25684AB0" modified="2023-02-22" version="1">MDDYASIMVKALADRLAEAFAEWLHLQVRRNYWGYSKNEDLNATDLISIKYEGIRPAPGYPTQPDHREKITMWEIMPAEKEADIILTDSLAMHPASSVSGLYFAHPQSEYFSLGKIDRDQVEDYANRRGESIEEVERWLSPNLGYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRK3</accession>
    <name>A0A914YRK3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRK3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2286.t1">
        <property type="protein sequence ID" value="PSU_v2.g2286.t1"/>
        <property type="gene ID" value="PSU_v2.g2286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005428">
        <property type="entry name" value="CD36/SCARB1/SNMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF103">
        <property type="entry name" value="SCAVENGER RECEPTOR (CD36 FAMILY) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01610">
        <property type="entry name" value="CD36ANTIGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2286.t1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56489" checksum="86FC95B48D61213F" modified="2023-02-22" version="1">MDEKPQKFQLKKWQVVVISLLTLSLLGFAICLTILISLAPLIEKNIRATTYLEPGSSVFEKWLNPHYMLETRMWTYSVKNPDEILNNHKPVVKKQGPYVFDQVHKRKIHSIENSTVKYETFSYYYFNESKSCETCYLYNRVWIPNMIYQKFVEAASKPSMKAATAALLVQTPFLEVEVSEMLFEGYADPFLDQVCSLPFVNFVCESVLDLPDRIGFFFDKNGSTSGVYVVDSGLTDADLIGNIRTWNGQNRVPDGWWSNYEATEIHGTDGTLFNPFLSKEQKITVFVKDLCRSIDLYFKEEIDYKGITAYRYVIPQKELDTTRPENKGYCNENNKIIYPEQAKDCLPPGLIDLSRCQRGEPPIIFSLPNFLYAPKYVQDSVEGLDTPNVENDEIELDFEPRLGSLFRAIRRSQINIAMWRGANLTIPKFRNVIIPVIRIDDIAEMDTPTFDLIKEKLILTERLVRTITITGMATAVILAILTGMLCFYKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRX4</accession>
    <name>A0A914YRX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRX4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3498.t1">
        <property type="protein sequence ID" value="PSU_v2.g3498.t1"/>
        <property type="gene ID" value="PSU_v2.g3498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3498.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="30881" checksum="E706ECD4FF8DA652" modified="2023-02-22" version="1">MRRATGLPASMNAWVLEQYKTPLVKKEVPIPQITQPDQILIKVKAASVNPIDTWIAKGYGKNILSTWRQFEKGSLQSTSLLPLTLGHDCCGEIVDIGSNVKNFKLSDEVIAVIPGTWQGTHAEYVLTKANAAAPKPIKANYIEAATMPFVACTAWAALVTAAQVNPNNASGIRALIHGGSGGIGSAAIQMLNAWGAEKVVATCASNNMDYVRSMGGIPVDYEDSSAKERLKSEGPFDVILDCVSSDLAKWSDNVMKSWKNSVHLLLFHLMVDFLLMHIFGQIKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSF8</accession>
    <name>A0A914YSF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AXH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2946.t1">
        <property type="protein sequence ID" value="PSU_v2.g2946.t1"/>
        <property type="gene ID" value="PSU_v2.g2946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043404">
        <property type="entry name" value="ATAXIN1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003652">
        <property type="entry name" value="Ataxin_AXH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036096">
        <property type="entry name" value="Ataxin_AXH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13392">
        <property type="entry name" value="ATAXIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13392:SF13">
        <property type="entry name" value="AXH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08517">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00536">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102031">
        <property type="entry name" value="AXH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51148">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AXH" evidence="8">
        <location>
            <begin position="443"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="747"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="768"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2946.t1"/>
        </source>
    </evidence>
    <sequence length="808" mass="88296" checksum="C5E0F6C31072156D" modified="2023-02-22" version="1">MQVPGSTNEIQNVPNNTTPPDLASIQQYVMLMNQQQQQHAAAVASLQNHQHQNSGTNPLATNALLFNALNRSNDPNFALSALQSPSVDLSQAAFVLNNERRPSTHFLPPHSAPTTAGGQGPQTSNIHPQLTPVHQTPPMLSPLLQAAVQQHHHQQQQHHQQQQLQQQHQHLQQHHPSLSQQSLEELAALSQLNPNLIQANLISELQREVQRQQSAAAAAAAAHQQAQQFQHLQAALQQANVPPGHAQQLLSVLQQQHQAQQQQQHQQQQQQQLMAQQSLASGLFTPGGGMRQAIKPSMQPPQASPLLKQVTSINSSPINGMRFMEDQPSTSAKKLSQPQLPSIPMQIGGGLPKRASFSSQPSTSGTSAAAVAAGIHSRKSSAATIPNLPKPIPTPISKAPPPIPPLSIPSTSSSSSQQQQHQQPGPSTSSTTTSLMQQLPTPPGLPQQPYYPTHFLRGTSIRLESGEIRLIEEMKAEDFYKSSQLTSEMRVCIGEISEIKETQCCRFINLSYKMDIDGQAALGSMTASAEYPFYEIESGWSSYDPFKTLNLYGLKCKKIEIGDKCILLSKDFVDKDDSELKKKWQKQFKGQFKGYSKTQPTLAGATAPNDDEIKDFPMELQHQQQQQLQHQRSSHNNNGNNHGQNRLVRKSIPPPLAMNSTTGFPFIHQTNGPTTSQSSTSDSATPLTSTISAPADTYLSNHAFSLSLPSNEPFSAPAAMDDLTVDAQMAQEAAAAYANLQQQQHLLQQQHSSLNDGEAMQIDDEDPSPASSSSTIKQQPSSSSQQQQQQSQQSQMPSQEDVFLDFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTD0</accession>
    <name>A0A914YTD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTD0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2924.t1">
        <property type="protein sequence ID" value="PSU_v2.g2924.t1"/>
        <property type="gene ID" value="PSU_v2.g2924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2924.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8587" checksum="DB76B54B29DC0C82" modified="2023-02-22" version="1">MQFLEQTEMWGGNGNKMSCNGDAGALAFRICRRTCGFCDFDLYDNEKYSKNCPKINATRLSFMDPFQLLFLVGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTG7</accession>
    <name>A0A914YTG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Asparagine synthetase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTG7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20730.t1">
        <property type="protein sequence ID" value="PSU_v2.g20730.t1"/>
        <property type="gene ID" value="PSU_v2.g20730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="369"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20730.t1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54994" checksum="D3079C6E7467C045" modified="2023-02-22" version="1">MNLIDPLLINLLRRFSPDDISEFLRQYSVHGKTGTLFCTFWTGTEIVDDHLRFVDLPTLVFGRDIFGKKSLCYRIRGSLIECKRIPGEINSGWRDVPQGTVVIIRSLEMTRNGIILAQPDAALHLQFGFKDLWQAQAYVFSFIRNDAVNLFIERLKNSVRDVSFYRIPGGDSLLELNTELFPQEDIEEMKKNSVNEFINLFETILPLRYLPSTPETLLFLFSGGVDSLFVTVIAAMAANEEFEIVLVNVSFSESGGDFEAAPDRKRGLEAYEFLKQKFPKRTFNFLRVNVTKDELQKKRSSIIGSVVAPGSTVLDDSIGCVVWFACRAKGIQDGLETRYDHVERVFVGSGSDEILGGYSRHRGIFEREGYDELFNELRSEIQNIGNRNLGRDDRVALSNGRMMLAPFIDEDVVRFVNLLPIQLKVDFSLPRGIGEKIILREALKQLGAPETLYTAPKKAMQFGTRIAKLENRSEKGSDQCVRLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU55</accession>
    <name>A0A914YU55_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU55"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3524.t1">
        <property type="protein sequence ID" value="PSU_v2.g3524.t1"/>
        <property type="gene ID" value="PSU_v2.g3524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3524.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17481" checksum="5F3353ADF883F1FF" modified="2023-02-22" version="1">MADTVLIETTQKVAGETHYFGEPLALGIIAALIVIGIICIAKMWHRRHSPNSSDSAVPDLHNPQKQKGEDPSSIIISSSWSSGEEHVYYPPPPPLQNGQKLKPLSINRVETKQQQQLQNVLPKLQETHFPNSSKANDSSTFKCHNSNNTFKSKIISNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUG4</accession>
    <name>A0A914YUG4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4272.t1">
        <property type="protein sequence ID" value="PSU_v2.g4272.t1"/>
        <property type="gene ID" value="PSU_v2.g4272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="176"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4272.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38463" checksum="6605B3436ED6768F" modified="2023-02-22" version="1">MSCQSGIRADNELMTFFEDCKRGKYRMGKIVINKEKLVVNYHSQPSNDWKADWKRDLPNCVDSYEPCFILFRLETPHDWILISFADDKASSRDKMVLAATKATFKSDFGQSFIQGEFQISSTHEFNLDTFERRLHKGGIRENETSAMTSFEQDRSAASRERIALPLAMQATQTLRGVQFPVDQDATALIKKFGKGEIDFVQLSVDTLNEAIKLEGNEERLDASSLNSKVTKQKPRYTLFRLREVDEHPVFFIYSIPPSAGCTIKELMLFSSCKAPFLTEVEHNCGVKIDKKIEVDSRDKLDAEALISYWRPAAIEEKKPFARPPRPGSGPRRITAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV37</accession>
    <name>A0A914YV37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial folate transporter/carrier</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YV37"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4463.t1">
        <property type="protein sequence ID" value="PSU_v2.g4463.t1"/>
        <property type="gene ID" value="PSU_v2.g4463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="102"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="203"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4463.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33370" checksum="6B567852900E2B55" modified="2023-02-22" version="1">MGIADYEQLIAGFSGGFAATIVCHPLDLLRIRYSVNDNNASLRPQYRSYFHAIKSIVKAEGVRGLYQGLTPNIIASPLAWGLYFQFYHQMHPHFNYLSNAVSLPFQNLVVGCAAGASVMAVSNPLWVAKTRLCLQYENEAAKTYRGMIHCLRKILQEEGIKGWYRGFVPALFGTLNGAIQFAIYNYLKDWRYRTQNLSRDKPLGTLDYLVFSSASKMLSTASTYPYQVVRARLQDHHTNYSSSREVMYRIIKNEGFTGFYKGMFMTTLKQLPNGIVTYVVYEHAKQLIEKFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV84</accession>
    <name>A0A914YV84_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the methyltransferase superfamily. METTL16/RlmF family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YV84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4505.t1">
        <property type="protein sequence ID" value="PSU_v2.g4505.t1"/>
        <property type="gene ID" value="PSU_v2.g4505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017182">
        <property type="entry name" value="METTL16/PsiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037350">
        <property type="entry name" value="Mtase_ZK1128_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037350-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4505.t1"/>
        </source>
    </evidence>
    <sequence length="468" mass="53567" checksum="3F11B4F941FFE3D6" modified="2023-02-22" version="1">MALNHLMHPRNVYKNRPPDFRVLAEKYPDFRQYATFAPDGKVSLDFHNSDAVRCLTEKLLKEDFKLDVILPVDALVPRIPQRLDYILLVQDLLNASNLYDNVLGIDIGTGPSCVYPLLGAKHCKWNFCATEVNEESVAVALKNVEKNQMNDKITIFQGDESTFFKEIFKAYPDKIFSFSMCNPPFFNKEECEERFQRSDKSDFKNNPNASNTPRAPPSSATVARNSELWVHGGEVDFVTRMIHESALYPSKVQLYTSMIGKKMSISPLKKVLEEYKNLIYATHCIAQGRTKRWVLVWTFNPTIKVNSRLANKTLSFSKNKDDVISFFCQICKWANVEVSKHSSGYLICFIPSSKMLSFKPWKTKKRKNDNNEVPKKFMKIHSPNTQDRAEINSNISDKNNADSQLSVTEVTVNQPQLVDAKNIRLVVNKNANSSSQLNVEFFNNDMAGFRWLESLINYVNGNPNIFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVB6</accession>
    <name>A0A914YVB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVB6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21448.t1">
        <property type="protein sequence ID" value="PSU_v2.g21448.t1"/>
        <property type="gene ID" value="PSU_v2.g21448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21448.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16222" checksum="C2122F424AAE5B0F" modified="2023-02-22" version="1">MRQVSEESESDSEEESRPNVPRKAPSQAKKQRPNNDAVVEPRRPATTNDERSNNRAQNVPIVCDSSDSESSDFEAIAHRRPIKGEFGEANICRDPQIPEKELFFHYGVKSITELRKLRQMVVPHLINDLDDFHKFRSTLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVG5</accession>
    <name>A0A914YVG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVG5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3653.t1">
        <property type="protein sequence ID" value="PSU_v2.g3653.t1"/>
        <property type="gene ID" value="PSU_v2.g3653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028460">
        <property type="entry name" value="Tbh/DBH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00767">
        <property type="entry name" value="DBMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="4">
        <location>
            <begin position="107"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3653.t1"/>
        </source>
    </evidence>
    <sequence length="483" mass="53918" checksum="B668FCAD46545C49" modified="2023-02-22" version="1">MSEGLTLLTLTPDNLDGYVDISKSLITDIQQDCELISSDQNGFSFKRKWITCDPRDIILSKGATYLFFASDVTEASNINEISSHKAKLFSPNISPTQLESDIVVLSITASNLTVSDNKQWCLIKKLSEDLRTKKNHLVRIEPLITVGNEKVIQQIELYYCNNFDGKDSIEYNGTCQGEKPKNCTKSVFVWSLGASPFDFPKEAGLPIGGSEIFGGFIMLKIEYVNQNPINDSSGFNLYYTPTLRSNDAAILELGISPTTANAIPPKQKSFALNGFCLPECSAKFPDNGITVFGSRLHTHSLGKLVRTSIYRNGKRVGNLNFDQDFVYNWHIVDTLEPQITVEKNDMLMTTCVYNSQNREKITFGGDEPTDEMCSNIVYYYPAMEISACKSAIEDDALQTWFAKKGNADASKTVKEKYESLSAAWNASLIDDLIELYFTSPLKAECLNQSGVLLDGMKNLKKPFISKISEESRIKYECPSIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVH9</accession>
    <name>A0A914YVH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVH9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g459.t1">
        <property type="protein sequence ID" value="PSU_v2.g459.t1"/>
        <property type="gene ID" value="PSU_v2.g459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g459.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18165" checksum="34F1F356FEED0AC4" modified="2023-02-22" version="1">MQILIFQEQAGIPVIPLSGIRAQNLREEAIREFRDNNVSVLTVTDIASRGIDIKDVDVVINFDMPLNYTTYVHRVGRAGRIRNGKSFSFVVPESDGSVVIELKKAMEAAGHEIPQSLNNVIDQCIIAESGLQPTGFGNGFKKQTNATVPAAVDKSKEAPSAAVCHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVJ2</accession>
    <name>A0A914YVJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVJ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g400.t1">
        <property type="protein sequence ID" value="PSU_v2.g400.t1"/>
        <property type="gene ID" value="PSU_v2.g400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.20">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g400.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="9925" checksum="AF660F4859C7E545" modified="2023-02-22" version="1">MKKLLNGLHYCHVFSSSSQIGNNHSNDAEMEDTDNVEVNGSEVDGSEVVGSEVDGSEVVGSEVDGSEVDADSVDDESESETEGPAVAILHDQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVK4</accession>
    <name>A0A914YVK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfate adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVK4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3691.t1">
        <property type="protein sequence ID" value="PSU_v2.g3691.t1"/>
        <property type="gene ID" value="PSU_v2.g3691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000027">
        <property type="entry name" value="Sulfate adenylyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000031">
        <property type="entry name" value="Sulfate adenylyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP-eEF1A C-terminal" evidence="3">
        <location>
            <begin position="120"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3691.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28112" checksum="EA3262CDBFD3D61E" modified="2023-02-22" version="1">MAWYSGPTLLEVLETVEIQRVVDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSGVESNVARIVTFDGDREEAFAGEAITLVLTDEIDISRGDLLLAADEALPAVQSASVDVVWMAEQPLSPGQSYDIKIAGKKTRARVDGIRYQVDINNLTQREVENLPLNGIGLVDLTFDEPLVLDRYQQNPVTGGLIFIDRLSNVTVGAGMVHEPVSQATAAPSEFSAFELELNALVRRHFPHWGARDLLGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWK6</accession>
    <name>A0A914YWK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWK6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2464.t1">
        <property type="protein sequence ID" value="PSU_v2.g2464.t1"/>
        <property type="gene ID" value="PSU_v2.g2464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2464.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27826" checksum="164BDFFF6A6E0F46" modified="2023-02-22" version="1">MKLKDSLISGKEIHEKLNRELTDTTNEFENLHNKNDELSEPSEELEIQLQAALNKKARLEKQNSEMAKRVQDLSVMTEAQETILQYKNEVENVTAEKNKLSQRVKELEDALLNSSKSNRIPKTENDDDSSMNFLNSIIAEQQKKIEKFESFLDSIGQRLPSLTAAPSVSARVGQPPTQSAPKSYVAPANREYCDICEEFTHDTKLCPNRPISPLPTFIPITKIRAFCDECDMFYEDKCQLHSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWM5</accession>
    <name>A0A914YWM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g495.t1">
        <property type="protein sequence ID" value="PSU_v2.g495.t1"/>
        <property type="gene ID" value="PSU_v2.g495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF3">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g495.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8302" checksum="78D7DB2EDD67E4E1" modified="2023-02-22" version="1">MYLVIKEHLSLREAFIEIDKIRPFISPNLGFWTQMIEYENKLRGEASVKILAEEKVPIPDVYLYKNMIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWT6</accession>
    <name>A0A914YWT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWT6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4423.t1">
        <property type="protein sequence ID" value="PSU_v2.g4423.t1"/>
        <property type="gene ID" value="PSU_v2.g4423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4423.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35848" checksum="5A858AB0B5F08977" modified="2023-02-22" version="1">MSSEKAARRASRRVFKRPKLTNSQRAAYYGYSEFIKNESDSDETTTADEKMQVHESSNRSSQFETSKAFIISSNSALGILDKTKNAANTRDDEQEVLDHTTSYGPSETSKASISFSESVLNVFDKPRLRDATFYDDNENASKIFDDEIEENSTHVSNESQEIFEKSTVEYMEEENEYATKISFDREGTPKITTAYPEETPEMKSPCLKKLAEAAAPVAKEPITTLSQPVKTRAALLLPRFMQQTNASSSRTNRPPVMCSSPVRGKKFVPLPSPKLRAPLTPRKSVAVLRKVADQSFNAAKLPVLDMALFEDIPKKIITDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWY3</accession>
    <name>A0A914YWY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWY3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4617.t1">
        <property type="protein sequence ID" value="PSU_v2.g4617.t1"/>
        <property type="gene ID" value="PSU_v2.g4617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF30">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038100178" evidence="5">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4617.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15919" checksum="D945D0CEEABAF611" modified="2023-02-22" version="1">MHQFFIGVFISGILMAMSSASVQSTAIRGSVVCGRERFGRVRLELWDKDRTDPDDLMMKPVHISYGDTFTLDGKENEISTIDPELRIFHKCGDERARCYKKSIILIPDEYVTKGERPKKIFMAGRIDLRNIKSVDTKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY97</accession>
    <name>A0A914YY97_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914YY97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4924.t1">
        <property type="protein sequence ID" value="PSU_v2.g4924.t1"/>
        <property type="gene ID" value="PSU_v2.g4924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="109"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4924.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38593" checksum="4F1128C27158A11A" modified="2023-02-22" version="1">MFGKIIDKYLGEQRINHFYVENNGEKEIVSVEELALRHFRQEQNFWNGMHSEGQIWHTVFGIICYDIIFDHNIDTVWFSPIQDSPADLNTLDFFLKRKERFEERLSLLLEEGQKEILTDIMKDNFVKNRGRTNAKIDWNMFESFEEFENFMLCINPEALVMIINRIIEDHRHHRSGFPDLTLWDPATKRLAVIEVKGPGDKLSTKQRLWLDFFNKHGVDAFVCQVTANKNRQLPNPSVTKKSKQKKTKKETNEVEGEEMEVESIEDIEDIEIVKADCDLDEFEEEEEDEEVADFNFVSSSKPSSSSSVRVTRSSSRNKLSADLNDNGSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZD2</accession>
    <name>A0A914YZD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZD2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5308.t1">
        <property type="protein sequence ID" value="PSU_v2.g5308.t1"/>
        <property type="gene ID" value="PSU_v2.g5308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036781059" evidence="2">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5308.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12486" checksum="8339D342C13AF306" modified="2023-02-22" version="1">MKFQILFLFAVFVFINGLTDGNRNVRQADFQTDQLEAKLLQSNLQTFNGRTDGVSISQNENVAYGIKGTFVFKAQAGTGQNVIRPANNGQNVIRPANNPSPLVSQPRSSLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0I0</accession>
    <name>A0A914Z0I0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0I0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5855.t1">
        <property type="protein sequence ID" value="PSU_v2.g5855.t1"/>
        <property type="gene ID" value="PSU_v2.g5855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004511">
        <property type="term" value="F:tyrosine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006585">
        <property type="term" value="P:dopamine biosynthetic process from tyrosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF15">
        <property type="entry name" value="TYROSINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5855.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28911" checksum="F0EE4A9ADB525057" modified="2023-02-22" version="1">MIQKLNSVGIALKHVETRPDKAHPGELEILAQIETRKPLLMEVLDHLIADKIDRIEIKSSEKDNTITSSKNVASEENIWIPTHVSDLDKCGHVVVKYEPTEDPKHPGFGDESYITRRAELNSIAKNWKFGDQMPDIEYLPEENETWKISYLKLKELRESHTCEQYQRNIKQMEDIGLITAEKIPSLQAIDKYLRAKTGFQLRPCGGLLSARDFLASLAFRVFQTTLYTRHHSKPNHCPEPDLIHEILGHTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z100</accession>
    <name>A0A914Z100_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z100"/>
    <dbReference type="SMR" id="A0A914Z100"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6035.t1">
        <property type="protein sequence ID" value="PSU_v2.g6035.t1"/>
        <property type="gene ID" value="PSU_v2.g6035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048001">
        <property type="term" value="F:erythrose-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23937">
        <property type="entry name" value="GAPDH_C_E4PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17892">
        <property type="entry name" value="GAPDH_N_E4PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000007">
        <property type="entry name" value="D-erythrose-4-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01640">
        <property type="entry name" value="E4P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006422">
        <property type="entry name" value="E4P_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01532">
        <property type="entry name" value="E4PD_g-proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010058">
        <property type="entry name" value="PRK13535.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="10">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6035.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37299" checksum="4CFC4BD2267EA2A2" modified="2023-02-22" version="1">MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1G3</accession>
    <name>A0A914Z1G3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1G3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6197.t1">
        <property type="protein sequence ID" value="PSU_v2.g6197.t1"/>
        <property type="gene ID" value="PSU_v2.g6197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6197.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33585" checksum="F39A935531AE743B" modified="2023-02-22" version="1">MAEPPSKTSNHQRVNEMMAHLTPKGATIPYNLSFDSDNCIWVASKGGLFKLNPEGDKVLVEKKNIFPKKFAPYCQVIIHGNKVIHAQCEDVADITEFRILDLEGNIEHEQFIDGKIQSLAISSNGDIFLTKQPPKGADEFFIYKTSIDVPLGWDEFVSEFDLCYQSLCSLDDSTLVAATCSIPNNIYSKQNIVFLDAETGKLKKKFSEAGKDAGQVYFPRCIQPYQDGILVLDKTGRIQHFGRDGNLIAESARIDAYIGNGFVVRNDEAVIACSGIVLAADGESVCDDWIEAIKLDGSFWTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1P5</accession>
    <name>A0A914Z1P5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1P5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6033.t1">
        <property type="protein sequence ID" value="PSU_v2.g6033.t1"/>
        <property type="gene ID" value="PSU_v2.g6033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6033.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22824" checksum="612900D5010FFB4C" modified="2023-02-22" version="1">MAAEPNAPWSRWDAPGFQYVSQNTQPPNRQFDTGQYTITNTSLGNNGNNNNIRYYDDGRLVDSRPNANDPAFIDCVYQSVNGGAQIVQQCYKDFGCCDRRCCEGSSWGEKYGWAVALIVIFCILVIIAFLIWLFVWLINRSRDKKQRRELLESPQGMSPAQSQINVGGNGPYNSGPPSMGGLPPPNQGMPGPYYQPYGSKPYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1V5</accession>
    <name>A0A914Z1V5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glycine hydroxymethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Maternal effect lethal protein 32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Serine methylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z1V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6344.t1">
        <property type="protein sequence ID" value="PSU_v2.g6344.t1"/>
        <property type="gene ID" value="PSU_v2.g6344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF59">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="12">
        <location>
            <begin position="51"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6344.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30559" checksum="53A590AF7ED50B44" modified="2023-02-22" version="1">MLAISNRSVSITKVTTFKRFIKMASNGVHTSLIEVERTPYAGKNLIRDPLSVADPEVLQIIKDEKKRQRRGLELIASENFTTKAVLDTLGTCLSNKYSEGYPGARYYGGNEYIDKIERLCQERALKVFGLDPEKWGVNVQALSGAPANFAVYTALVEPNGRIMGLDLPDGGHLSHGFATPAKKVSATSMFFQSMPYKLDPKTGLIDYDTLEKTSLLYRPRVLIAGMSCYSRNLDFPRFRKIANACGAYLMTDMAHISGLVAAGLIPSPFEYSDIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1W0</accession>
    <name>A0A914Z1W0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z1W0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6349.t1">
        <property type="protein sequence ID" value="PSU_v2.g6349.t1"/>
        <property type="gene ID" value="PSU_v2.g6349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6349.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25358" checksum="82CF16B5F0BCD68A" modified="2023-02-22" version="1">MKPYELYLFIYNLFQVFGWGIILVKTFLGITKNQSNEELYNNVAIELAIFQTAAILEIIHAAIGFVRSPVATTATQVFSRVVVVWTILYKVPTSRSSIGVLMLLVAWSITEVIRYSFYALGLIKSVPSILTWMRYTFFIILYPMGASGEVLTMLAALPEIYQKKHLSFELPNALNFGFSYYYFVMILCLYYIPGFPQLYLYMFQQRKKYVGGGVDSKKKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2M9</accession>
    <name>A0A914Z2M9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2M9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6963.t1">
        <property type="protein sequence ID" value="PSU_v2.g6963.t1"/>
        <property type="gene ID" value="PSU_v2.g6963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6963.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15246" checksum="76000498C553AE2D" modified="2023-02-22" version="1">MMKEQGIEESLVKDFELVVGVLEWEMDEKNVLESDLPPLGPESTRFVDISTWSILFFDLLHDNMHRIVDLNYSLKMLTKTRRKQLKKYEEKAAKILEEFENNVASFNLDGESAKAYKKGVSEIRKNCKVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z366</accession>
    <name>A0A914Z366_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z366"/>
    <dbReference type="WBParaSite" id="PSU_v2.g470.t1">
        <property type="protein sequence ID" value="PSU_v2.g470.t1"/>
        <property type="gene ID" value="PSU_v2.g470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g470.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30171" checksum="744E3D70C0AB53A2" modified="2023-02-22" version="1">MWCVLVSGASGYLGLHCVKQLLEAGYIVRGTVRSLNNSKKVEPLRSLPHASERLELVVADLEKPDSWPSALQDCTYILHTASPFQINPDESCIKTAVDGTLNVLSAAARTLTVKKIVLTSSCVAIMEGHEDSTKVFNESDWSVTTPTTNPYFRSKVSAEKAAWNFVKNFGNDDNKFELTVINPSFIIGPQLSDIEGASANTNSKTDGERIIAASQPSIWMKEIAKALGNEFTSQGYCVPKHKAPDMIIKAASLFSDQAKMVSERLNVECKIDNSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3F9</accession>
    <name>A0A914Z3F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LAGLIDADG homing endonuclease</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3F9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4786.t1">
        <property type="protein sequence ID" value="PSU_v2.g4786.t1"/>
        <property type="gene ID" value="PSU_v2.g4786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056053">
        <property type="entry name" value="DUF7636"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24642">
        <property type="entry name" value="DUF7636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7636" evidence="1">
        <location>
            <begin position="164"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4786.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="31484" checksum="FEA2D782FBF420FE" modified="2023-02-22" version="1">MTKYQIRSEGELFANAFLELTGDFKNQKRFGEGSVTAIVEQKVSEIFEEFRIKMLDRFQLNWKFDMQQKQISFSNYQIMNVTEEMISLAKRYYAVSEENRNFFSFPWILWEGLDAWWQLDPNRKALNIPTLNNNQGYSLQVQSIFIKYAFLPNDNSNINLYQQIINYRPFVVYIPNVWAEGFQQNYRILERKSGCNEIVVGLKKTFQNYHHYTVMCRGTLESCRKLEAMLTPFINPDVDNTVPFSEMKNRKNAAMQNVLQNLFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3G9</accession>
    <name>A0A914Z3G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3G9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7239.t1">
        <property type="protein sequence ID" value="PSU_v2.g7239.t1"/>
        <property type="gene ID" value="PSU_v2.g7239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7239.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14147" checksum="099A8AE26546F1A0" modified="2023-02-22" version="1">MSKESEKFPACSISFDSYALQRLERLENQTRRLNDELKIEIEFSSRIEKEHADLTKQLEKMIEKEMNKERSWRKNIELAVKVDEIAKIEKASENALHVAQNNQTEKKKVKRKTKDKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3K3</accession>
    <name>A0A914Z3K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3K3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6475.t1">
        <property type="protein sequence ID" value="PSU_v2.g6475.t1"/>
        <property type="gene ID" value="PSU_v2.g6475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF268">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6475.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="29330" checksum="344EDCA41088B2E9" modified="2023-02-22" version="1">MLLSKIDSITTNLEIDMNEFRSLQSEIWVKAVGNGKSQAAGVLLPYLRQKRQYDARSEPGQCVCQLENKCTPGPAGKDGVPGEDGAPGIPGAPGAPGLPGNHPPVPLDVANNCRSCPGGEPGYPGPPGKPGDHGPLGMPGTKGNSGHPGYPGPRGPRGSIGEHGESGKMGPKGPNGMPGIMGGHGESGRPGNPGSIGPPGFKGPAGMPGHSGQPGMPGERGPEGLPGKEGQPGHPGPRGGDSIPGDDAGYCPCPKRTEQQQPTEEVSNKPAEGGEIEVEGASENSYGTKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3P4</accession>
    <name>A0A914Z3P4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3P4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7317.t1">
        <property type="protein sequence ID" value="PSU_v2.g7317.t1"/>
        <property type="gene ID" value="PSU_v2.g7317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7317.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15791" checksum="E7BE461E2C9B7D2B" modified="2023-02-22" version="1">MVLVGGKKVKIVHKHTRRFTRHESDRYKRLRPNWRKPKGIDNCVRRRFKGTRRMPKIGYGNNKLTRHVLPNGFKKVLVNNVRDLDMLLMQNHRYAAEISHGVASRKRKEIVERAAQLRIKVTNGTSRLRTEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3T0</accession>
    <name>A0A914Z3T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3T0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7360.t1">
        <property type="protein sequence ID" value="PSU_v2.g7360.t1"/>
        <property type="gene ID" value="PSU_v2.g7360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7360.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11217" checksum="3DE4A8041E0088E9" modified="2023-02-22" version="1">MKDVEKLVDTLDDPHQQLYHQFMDESDKTQQTKRDAIHKTVDGMSVDAQGQFAKISAILTNPTLPEEERWNRILTIYGKLEPSLRNEFEEKFKPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4A6</accession>
    <name>A0A914Z4A6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4A6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g672.t1">
        <property type="protein sequence ID" value="PSU_v2.g672.t1"/>
        <property type="gene ID" value="PSU_v2.g672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g672.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26000" checksum="CDAFEF82540410F9" modified="2023-02-22" version="1">MESKLRRVKESTIQKWKKSRSNDNNNQLQKPEINENESIKIDENCIQIISRAPSQVVIEKSEGNEIKRVNGKRKMIKALNDKTEEKDSSEFQLENGCLKVNENLQPDRLHVESNAASDIESIFEADSESLHSKKAENRQQNNLKSSSFGGCEEICTPSEDHLADTAQNTYNLDSNDDETSHHDNSTNVPHKKSSNLLDFNYIIDRVGSRVIRVYKDSDSSHFYCNAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4F1</accession>
    <name>A0A914Z4F1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4F1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7230.t1">
        <property type="protein sequence ID" value="PSU_v2.g7230.t1"/>
        <property type="gene ID" value="PSU_v2.g7230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="11"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7230.t1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46638" checksum="F36F3453104A5C5B" modified="2023-02-22" version="1">MFSDFEINFTIEILKLLNADNKPNAFSPMSIFNSLAIILAGSEGPGANQICTVIGKGKSRDAVIKNYASLINFCKALNESAIGHVYCKNLFLSDEPFTSPAAEVMHKFDAEYKQLNFDADAFLREINDFVSQNTKNQINNCITNKDVSLMKKSVTIVNALYVDHIWDNPFTYESLFQFLEPPFKHYSVRKTRCIFRQIENEGWNLTQGENWKCLGIPYKSRKTWIHILLPNEYGDLNELLQKFDVEMFKKCIAKQAARKMKVIIPVFEVETKICLNEILNKLGFTDIFNAENVSNILSHPCYVNNFFHSTKINVNQTGLETPFYMNLTKEERFKLAEEQEYEPEIDFEGWKRLEREERDEDAEIEDLEIERFNANHPFIYFVTLVNDSVEDLKTIITMGKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z721</accession>
    <name>A0A914Z721_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z721"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6046.t1">
        <property type="protein sequence ID" value="PSU_v2.g6046.t1"/>
        <property type="gene ID" value="PSU_v2.g6046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161270">
        <property type="entry name" value="PspA lactotransferrin-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6046.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14778" checksum="606C96AF921CA123" modified="2023-02-22" version="1">MSQSSKIGNGFEPQKKMSALQKQASIIEESNSKLSDLKAQLSECRNENTAFKKEVNDLSKNVALKDYKIEELENKISVITKQIEILNGSTEDIKKLRAEVDKSHGLEDYRILEFYFLQQEKFKDIEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7V5</accession>
    <name>A0A914Z7V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8412.t1">
        <property type="protein sequence ID" value="PSU_v2.g8412.t1"/>
        <property type="gene ID" value="PSU_v2.g8412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01371">
        <property type="entry name" value="KISc_KIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000029">
        <property type="entry name" value="Kinesin-like protein KIF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1213"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="27"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="386"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8412.t1"/>
        </source>
    </evidence>
    <sequence length="1236" mass="140791" checksum="8AC84CF49CA0384F" modified="2023-02-22" version="1">MTQLTQELSAAPESLLRSTASNGGAETVKVIVRCRPLSEQEVKNGHDKIVSMDTTRGVIEVKNPKDPSCPPKSFTFDAIYDENSKQIDLYYESFREIVESVLTGFNGTIFAYGQTGTGKTFTMEGIRDDPDLRGVIPNAIDHIFRHISQSTNQQYLVRASYLEIYQEEIRDLLDKKGNNKLELKENPDFGIYVKDLTSYATKSVDDILQIMQAGNSHRSTGKTNMNEHSSRSHAIFMITVECSQPDVTGKEHIRVGHLNLVDLAGSERQSKTGAQGERFKEATKINLSLSALGNVISALVDGKSSHIPYRDSKLTRLLQDSLGGNSKTVMVANIGPASYNFEETLSTLRYANRAKNIKNKPRINEDPKDAMLRLYLETISNLKSKLDERSSSANRKRRKQDGINENENIEESEEMNAEEFLREQQRKLDEDRLALEQNAGMREEEKQKLLKSLEERQNQIADERDAQKRVADRIKSMQSKLLSGSRNLLDQTKEQQKLLQARRIELAEQKRREREILQQLEAQEDNTAEIHQTFASLQQEVEVKTKKLQKLFSKLQQIRLEIQDNAEAYSKERQQLEQSIGEMNKELKLKWLIVENFIPVSIVEKLRERAVFDENDGNWRIIKPGERPGSREMLEKIEPKTMIDSGLGPGISEVSTSIEEPVKLTPIKRPVSMIGLRRPATNFERDAIMHLRQRVRSARKNHALSPFFSNIQLESHSLDKAFVPDSVIRFCGENVITFGSLEAFPTKVKENPDEIISSDRLNSEASKDSDNNKLSQNVVIEVTKIPAPNRSSTNLRQTFLQNTNSQAAVDDAAAIEMVPLYCQTFCEEKKNHIGSQASSPELFTISSSSSSNDQGLGDEIPDDSDCFENSVNELETAINKRFSFYENIPNMDSSLNFSPTTFNENNKGIKWRQNIFPTGKPPIYTPMKKTKIPKLTSMSSSISEANTRAFNTQPDAKNICRTLTSGGQSFNLSQSYHGSTNASNHQWQLPRFSLTTQGSAEQLAERILTPKEECSKLLRRCKEDWRRPLASTTSYFPERSVIMPIKRHFPIPEILTSFSHDCDYLPPQQEISQTIQNCLSKIMKAGETLKNIEDDILLPPRPFTKLKEKPKLERNPDADKYKNPFGGKIQPIERQLALFRNPRTHCICCRCERALHRLQQRIYRHRKPVTVRITKRYVVIRDRCHCFANKDTDLNGISTLNSKPSLFVNEPPFAYIIWLAALSCIIRVLLFIFYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z874</accession>
    <name>A0A914Z874_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z874"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8879.t1">
        <property type="protein sequence ID" value="PSU_v2.g8879.t1"/>
        <property type="gene ID" value="PSU_v2.g8879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000052">
        <property type="entry name" value="Lysine histidine transporter-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="54"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8879.t1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54964" checksum="88A37DCEC816982B" modified="2023-02-22" version="1">MGKTRSRGNSVTFSTNKDIIYDAWSIGDKKSDSADSDENGDGRFENGVFIKNHGLNWFITGLFVVGDLAGGGLVALPTAMIQLGFVVGIVCNIVMNITVMITAYMLGVSWNVLVRRWPEYRSHCRKPYPEIAYRALGRQCRLLVSICIDVTQFGIAVVYLLLSSKNIHDAIKSFTDKEISFCYVILIVAVCLTPVLFLKSPQDFWWAVVLAMFTTSAAVILILLGSSLDYGECSKVRHEPKFRITNYFLGLGTLLFSYGGHSAFPTIQHDMKKPSDFTKSSIMAFIILFFMYTPVCIIGYLTYGDSLRDSVINSLQVSWIQQAVNLLITVHCILTLTIVFNPLNQEVEELLKVPQEFSIKRVFVRSGMMVAVVIVAESVPNFGPLLDLMGGSTLTLTSIIFPSLFYLFLAAGEKKAQRQKDSGEKDEEEFKPLTIREMIAETPKWVVALAAIIMGKKKIINIQTMLEIFFFFSFWDIWWCRCHIFCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z890</accession>
    <name>A0A914Z890_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z890"/>
    <dbReference type="WBParaSite" id="PSU_v2.g855.t1">
        <property type="protein sequence ID" value="PSU_v2.g855.t1"/>
        <property type="gene ID" value="PSU_v2.g855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF121">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="9">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g855.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19005" checksum="5D7FD2E8BE6CCE3F" modified="2023-02-22" version="1">MDRSISHEPSRPAFSREATIESVASCDIPLPPPSTNHLTPDRSQPLNLPNGINSSSNDPLFKLNIGGKSFKIRMDAVMTCRQPSLLTSLIKASHEQRILVVDGYIEETGEYYMERNVRVADHILDYYVTGLLHKPNDVCNERFKEELDFWKLRHDQLNIKQTKQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9A0</accession>
    <name>A0A914Z9A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rapamycin-insensitive companion of mTOR N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9A0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8394.t1">
        <property type="protein sequence ID" value="PSU_v2.g8394.t1"/>
        <property type="gene ID" value="PSU_v2.g8394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8394.t1"/>
        </source>
    </evidence>
    <sequence length="554" mass="62318" checksum="195102B616EFD641" modified="2023-02-22" version="1">MQKKKDLNLLKLSFACLAILVEFAINDPILVLECAGTDWIVRAVVGPGATNQTLATLVCRVLLKWLDTAEIRTKAKLHLVMEQIFAPLIDLGFFHQNQNELPKSDQPAMKINQILECVSTIFLSIFRSWTGVLSCGYVEENGDLASNSPFRLLHYLGLGTNVDITMVKIRNMVIDICCEFVDTPYATRKFVSWNDAVLYYSRLHLPDRYKTSLRDDFVVAEMECLQTSGAFHPDVVDCLMSFRAVASYILINVGLPQALARLIMASPDDPGGIKATLLLADMLRSGASFLPQDRRLMLLSAPSLVQAVSERIQYSAKLATGKSYDAQVTFPHSDNAMLLLNRLDQLNDTSFNRLSLESQLHNIELFVCGGKALDLENKNRERSTSQVSPEDRLEHLFTSEPEFFSKVTAKELDLTRLESIIDCLECDQGTLLTKHRYNDKLHSFYSRIFTIILPQNYRLVKNSSSFNAQIIKCICCAVKILVPLAKSEPYYGELIERFLHQFSEQLNPEVLYKGVFSPKNILNTCAHYYFAVLAAIGSSQNGIQLLEDAGILQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAB4</accession>
    <name>A0A914ZAB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7190.t1">
        <property type="protein sequence ID" value="PSU_v2.g7190.t1"/>
        <property type="gene ID" value="PSU_v2.g7190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036950976" evidence="4">
        <location>
            <begin position="29"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7190.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25905" checksum="83E8E68299608641" modified="2023-02-22" version="1">MAHNAMPLMVKNFLLAIFAFGFITFASAQCPNLQPPCRCAPSIYEPVAIICENAGSLSNALQAIEAARDIPIDSLLILDTAVTTIPANAFQDFTILRLVMNRNTLSQISENAFNGPLLDSLVELDLTDNQLGQIPQTGIHQLRNLRKLYLNRNRITTLSPNTFAQFESREILLKLELAGNRLTDEALSDSTVFRPLRSLQQLSLETNALTQIPSGALVNQRETLTNLNLGLNQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAN5</accession>
    <name>A0A914ZAN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8827.t1">
        <property type="protein sequence ID" value="PSU_v2.g8827.t1"/>
        <property type="gene ID" value="PSU_v2.g8827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903569">
        <property type="term" value="P:positive regulation of protein localization to ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8827.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45884" checksum="122CC0EC4CF235BA" modified="2023-02-22" version="1">MVSDHPSRASSADIQQQHLLKSVTKSIALQKTNGQNHSVGHVFTFHEVRNLRIEVRINDKIESELHRFENAIYGILTRMETDKIIALTVRKKGNIIATEKLTLLPGTYLFVINFCRRIPDSIPRRRYAIKEPSTGKLTSQYRLYTMNIFDMFDLNDDQVLDFREFSLYNILSGGGNFEGDEWKALIDNFDHRDDGLTLKAFVEMHHMEAESYETDDLKDMWLSVAELGFDEGFEPSKCCPVFIDYYLSDDEILIERYDTEHWKKNEKEDERMAEWYWNNGTTLPYLKNYALRLWKNDYFGALIAGPTSDSTRYELTVAGSKNVNLLVGADLVINRTIEANTFETLLIGLAVDTSKDWFISVRKLRRDRLISSEVPSAMNTQRSSLNHDHLQQLDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB96</accession>
    <name>A0A914ZB96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9929.t1">
        <property type="protein sequence ID" value="PSU_v2.g9929.t1"/>
        <property type="gene ID" value="PSU_v2.g9929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000202">
        <property type="entry name" value="Short-chain dehydrogenase/reductase family 16C member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF742">
        <property type="entry name" value="PROTEIN DHS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9929.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36423" checksum="DBDA6B1960038FB0" modified="2023-02-22" version="1">MKILRKRLTLVVSKKFPTAAFITSFYEYFVVLFWLTYYSFEGIIKALLPSGILPRKSVRGKVVCITGTGSGLGRLFAIEFGKLGARVVCWDINERLNLETLEILESQGIDAHAYTVDVSNRHSIYENAERVKKEVGDVDILFNNAGIVSGKKLFDNSDEMMIKTMEVNTMSLFFTAKAFLPKMLEQNSGHIVTLASMAGKSGTAGLVDYCASKFGAVGFNESLRAEMQALEKNVKVTTICPYYIDTGMFDGVETFAPYLLPILQPQYVVDRAIEAILTDQEELFLPRACYLLFAFSGFLPVKAGQVAANYLGINQTMDHFKGRTKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBG4</accession>
    <name>A0A914ZBG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GH18 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant self-incompatibility (S1) protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7593.t1">
        <property type="protein sequence ID" value="PSU_v2.g7593.t1"/>
        <property type="gene ID" value="PSU_v2.g7593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060320">
        <property type="term" value="P:rejection of self pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010264">
        <property type="entry name" value="Self-incomp_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46073:SF1">
        <property type="entry name" value="GH18 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05938">
        <property type="entry name" value="Self-incomp_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0713">Self-incompatibility</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="211"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7593.t1"/>
        </source>
    </evidence>
    <sequence length="579" mass="65507" checksum="0785CDDA189CDA3D" modified="2023-02-22" version="1">MVYEQMCELSDFECETYCLWKYYGDEDGASFGFASLNLLPIFGWDGWPLIDEQFGEPQKAGCKPGTYASVLVSNRRTCDKNVWIRCWSGDDKKKEWKILEKEGFGFQFKPVHNTLFVCEWVLDSTRQKIGFDVYGGKSDKTGKKNFYYAVKNDGVYFGTEKGKEDELKEKWDSPCEGNEDEEENNNNNDDTDVNSAEPTGESSVPAAACGKRIVGYYTGWSKREVDEEQLKKLTHVVFAFVAMRGDGSIAFDKKARKVNAGVHILFALGGWDNSQYFSTVAADSSRRTTFINNIIQFLKDEKIDGVDLDWEYPVTGGATEGVAADKENFVALLKELRGALDNLQKETNRKQPYLISYASAAGDWTMRPAYDLESIIKYVDFINIMTYDYYGAWGSKWGKYTGPPAPLFYGSPKGFSGKLNADFTTKYYSCNTKKPSKINMGVPFYGRFWKNVGAAIGDDEMWRVADEVGGKYEGGYVAWRDIGQSWNMGAAKIHEKVKSPYIWNSGSREYLGFENEESLKNIGGLMIWAIDQDDDANTLLNLVSSADLWNPGTLTEKTLTERTLTERTMTERTLADREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC61</accession>
    <name>A0A914ZC61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9507.t1">
        <property type="protein sequence ID" value="PSU_v2.g9507.t1"/>
        <property type="gene ID" value="PSU_v2.g9507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9507.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23867" checksum="1627C589715BAD0A" modified="2023-02-22" version="1">MNCVRDNDGRIELGNKDAVGRKIIERDDYGEAMRSAYMNDDNIYKFYDDNISMDIQVVAKVMDDVYEYKADDTFRIHVPKVDACNISVIYPSFDKLRGSCRIDREDIIIGMVNIGDGTPTEEEEQQTQEDDVQSHDADNLIQPEEVRCPRLSIDEQAHNTVMAAAEVYQQLIHAVDTANNMLVAMKKPNQKIREDLLAKVQLYLTDSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC98</accession>
    <name>A0A914ZC98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZC98"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9547.t1">
        <property type="protein sequence ID" value="PSU_v2.g9547.t1"/>
        <property type="gene ID" value="PSU_v2.g9547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF405">
        <property type="entry name" value="PROTEIN CBG12249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9547.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16307" checksum="EFF2E05385FA01FD" modified="2023-02-22" version="1">MVLLAGVADCVVVALLTPMLANASFYAIFIARLVMGLGEGFIFPSMSSTAARWFPPSERSTFAAIYTSGNQVAGVLGLLISSYLCGTNFLGGWPSIFYLFGLLGCIWGVAWLIFASDSPERNSFITEEEILYIKQQTAGQNTNQKSGSRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHK6</accession>
    <name>A0A914ZHK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHK6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9784.t1">
        <property type="protein sequence ID" value="PSU_v2.g9784.t1"/>
        <property type="gene ID" value="PSU_v2.g9784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9784.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19783" checksum="B78754AD64400D79" modified="2023-02-22" version="1">MSFSKLLQNSLVYTAAHCSICETKTAKMRQIGQNGDYIYSTLFFCKDGCTDRNLKLKDILKHPKVPATGDAVNNSGHVAVVGDVCASFTYPGVERKKIDPVVRAEGAERVVLGDVNNEIKNMKKRTRGTLGTLETSSDDDEATREAQKDTCMYKTCKYVSTFECPKKTWIKTKTFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRS2</accession>
    <name>A0A914XRS2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase OMA1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Overlapping with the m-AAA protease 1 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XRS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1069.t1">
        <property type="protein sequence ID" value="PSU_v2.g1069.t1"/>
        <property type="gene ID" value="PSU_v2.g1069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="10">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1069.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35271" checksum="DA838F471C68A911" modified="2023-02-22" version="1">MASPQAGMAALTGTLVGTRQGMISFTQQNEQEADRIGIQVLQRSGFDPQAMPTFLEKLLDQARYSSRPPEILLTHPLPESRLADARNRANQMRPMVVQSSEDFYLAKARTLGMYNSGRNQLTSDLLDEWAKGNVRQQRAAQYGRALQAMEANKYDEARKTLQPLLAAEPGNAWYLDLATDIDLGQNKANEAINRLKNARDLRTNPVLQLNLANAYLQGGQPQEAANILNRYTFNNKDDSNGWDLLAQAEAALNNRDQELAARAEGYALAGRLDQAISLLSSASSQVKLGSLQQARYDARIDQLRQLQERFKPYTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT16</accession>
    <name>A0A914XT16_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XT16"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10416.t1">
        <property type="protein sequence ID" value="PSU_v2.g10416.t1"/>
        <property type="gene ID" value="PSU_v2.g10416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000070">
        <property type="entry name" value="K+ channel tetramerization domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="108"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="257"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10416.t1"/>
        </source>
    </evidence>
    <sequence length="568" mass="64753" checksum="D6EFD9A9FA2C175A" modified="2023-02-22" version="1">MNTAVLQGTIMATTSHGIHRINRHANRSRNRHFTTTRIANYLNQIKSEYALSILNRTSLDIEDPLNGMPFTSPLNDPNDPGSSIAEVSDEKKMGIIIPKLKDTEELFNVNVGGVRFVYRIDTLIHRNQGLLSSLANLPHEKRLPHVDAYFQETNEYYFERHPLLFYSVFQFYLLGRIHHPPEICPQDIMEEFKYWEIDPSPFLCPWCCMDSDDEDEYEKRSDTSTQNIDEFKNLKFGPFRRCVWRIIEEPASSVYAQIFAIFSVLFVLISISGLVLGSIPDFQVAAKKSKTSLNVTLEREPHPILIQVEYVCIIWFSLEYFSKMLVTPNRWATFRQLLNIIDLLAILPFMIEMGLKIIGIDTEQLQDLKGAFLVIRILRVLRVIRVLKLGRYSSGLQMFGKTLHASFRQLGMMAMVVMTGVIFFSTLVYFLEKDDPTSGFHSIPAACWWCIVTMTTVGYGDLTPVTVAGKLVATGAIACGVLVLALPITIIVDNFMKVAESERRPGFSENTGVKRLGPRARVLVSEDPDAQQQQQEIEQKSIRKRKLIEQISKPIKTESSTPMLKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTG1</accession>
    <name>A0A914XTG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTG1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10253.t1">
        <property type="protein sequence ID" value="PSU_v2.g10253.t1"/>
        <property type="gene ID" value="PSU_v2.g10253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10253.t1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31617" checksum="B6A1F25E6F9977B0" modified="2023-02-22" version="1">MTMMHGNIINYADTFLLKASIDFNQIHDFGDLNFDEKQLSVNGYPYRFGVANKIDGKTFYRCMECRNIKNKKKLKNEIVGTLIFHTKEKLLKSDVNAPGGHQHLCNDPIFRPLPTSANNNIIASLASRILIESTFYHFEKLVLKVANQRYIFKHIGCTEGVRYYACLACIEQKSLQTQITENTDHRFENDAAVSDSGDDFDDAVSASDSASNVGIKRSHSQDLPPFDDHNFDDIDSVVMLDEIPQSVPSPAHSSDIQPPTKRRTFSSYFNFSFIPSLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUU9</accession>
    <name>A0A914XUU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUU9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10314.t1">
        <property type="protein sequence ID" value="PSU_v2.g10314.t1"/>
        <property type="gene ID" value="PSU_v2.g10314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10314.t1"/>
        </source>
    </evidence>
    <sequence length="487" mass="53124" checksum="F3281BC7C05A6C0D" modified="2023-02-22" version="1">MDEKLKAVSAAGESAEKDEALLECIKEVWNLIDNRIQNLEEKEVNIQSSLASSVCRLNNDESQIKLCENKQMVQQIVLQDDFKRPKSNLNPEPVKSKSLAEYVHDSVQSGLRIIDQKQICVEVHSEMTDETLKVFEDVNPYLIRDLPPLIGSSVFETGSFAKQHTNNAVSPVEDVIIELPQPLIHQNMSSAPSNGIQITVPPLAPPPPPLSVSTVIPFPSNQISLPSPKILTPKTITDVMDDKVLSVKRGPVIITPLTPSPVPSVKSNGNVQNSDTVSQNSHISNDTKSDTSTVTPIPVNNRCPPNLAEIIKNAPIINSKKKQNMSLFDDEEEEPLTKNLAVASNSSSVPQKPSPPISEPHFNSVESPKVSIPQSKPRTVLPPPQPQAPPRRSSPIVPSKESSPTMTKVVQIKKHKSLFSSSDEEDEIPVSRMSKPKIQETSNAVKDIPSSSTSKPVAPKRGQIVNNVNNLAQVQNSVSSGNKQVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVY5</accession>
    <name>A0A914XVY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVY5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11393.t1">
        <property type="protein sequence ID" value="PSU_v2.g11393.t1"/>
        <property type="gene ID" value="PSU_v2.g11393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11393.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38208" checksum="1F13C335363126A3" modified="2023-02-22" version="1">MSIIPTYNIILLGKTGVGKSTFVNSIANYSTYDSLEEAIEVNEPQGVIPVSFEITLKNFKKIKITQLGCNRRDVENENLNTKSSSCTQEPRVYSFYNENVGFNVIDIPGMGDTAGPTQDARNIQIIMEKLSQFTVIHGIFIMLKAFEPRLTADVKYNLNATLMMLHANAIPNIMFIITTSRGADYNPGETMTTLEDYVANLEASNGIKIELSENTVFCMDNEAYKFQCGWNKSDEYRKEFGPLIKNYSKSWDISSAAFFKLFERMYTMQGHHVQLSCAIGHARTIIHCLIGPLAAITALIQQALSPASREANIKALTKNGQQIKDEIEVQDTSSRTVYYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVY8</accession>
    <name>A0A914XVY8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretory carrier-associated membrane protein</fullName>
            <shortName evidence="5">Secretory carrier membrane protein</shortName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10691.t1">
        <property type="protein sequence ID" value="PSU_v2.g10691.t1"/>
        <property type="gene ID" value="PSU_v2.g10691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10691.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="30509" checksum="D66716812BC662DE" modified="2023-02-22" version="1">MSNLNDNPFADPFADPSITSATRPSQNTSEEYNPFAQQSGATSVPHGPTSAQTASIPPTSTTIPMSNDEIFRQQEELRRREQELQRRQQEFERRQNQGGAGTPRGGQPHNWPPIPAYLPVEPCFYQDIDVEIPVQFQETVRLVYYVYLIYVMALLSNVVASLFYSIFGDGSIGIFFLAIIQTILFTPCSFLFCKSIPVALIMLISAVSFSIAFAGMVFSLIKVHRFYRGAGFSVDKARKEFSDGVMNDATVRNATNQAARAAANHAVNEAVSGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW54</accession>
    <name>A0A914XW54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12166.t1">
        <property type="protein sequence ID" value="PSU_v2.g12166.t1"/>
        <property type="gene ID" value="PSU_v2.g12166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12166.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33571" checksum="CD1E41C2B95FA3C1" modified="2023-02-22" version="1">MSKRKINSTGSSPIIPRKAPRMPSNELAISTATDLLLELQNCENTELNAKTQMALNLLLNDLNMLKELLDSKDETIAAKNDIITVQTLRIEEMQQKNDQIQQIIDAPKIAEHRRSIVIQNFQESKFKSADESIQDDTIKVQQLISDIGAYAKVVACYRMGSKNEKEDDQRNQKKNFNRLMKVQLQTSSQARDILSNAKNLKGKVTYEGISIRRSMTNEERSIQSNQFQDMKNRIDELKKQNAGVNYCIFRNKICTKYLDGRTPTAVVNEKLNANVSGANSTPLNPRQFPTTSPMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWG3</accession>
    <name>A0A914XWG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11305.t1">
        <property type="protein sequence ID" value="PSU_v2.g11305.t1"/>
        <property type="gene ID" value="PSU_v2.g11305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11305.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24790" checksum="712C2E1FA418BF1A" modified="2023-02-22" version="1">MQFATSECQYSFAVQILLEISDEEINICENIIEIRRLAMGFIQKIFLTAPNVILTVHYQGYPLKYIPWMVELVPSVYIMVEHMEELIKHFNVERRIFAVYLIAHIVSSLSMPKHVHLAQMILLVVENQMALLEPHEKAIFFFNILPAFEIMSKKLEFVRPQIIGYIQKGIKIAHTRASVYPSMRLAMKQPERIIIEAAKETMQKIQEMQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXB4</accession>
    <name>A0A914XXB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1185.t1">
        <property type="protein sequence ID" value="PSU_v2.g1185.t1"/>
        <property type="gene ID" value="PSU_v2.g1185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157:SF4">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157">
        <property type="entry name" value="PRION-LIKE-(Q/N-RICH) DOMAIN-BEARING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037816493" evidence="1">
        <location>
            <begin position="27"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="278"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="337"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1185.t1"/>
        </source>
    </evidence>
    <sequence length="422" mass="46796" checksum="62D88F1B5D676531" modified="2023-02-22" version="1">MKHWFFKIFIFIFCQILLLNVQSIFATFGVPCTQKLVGSKCLFDEECYGTNTVCREGRCTCPTNFEEFDVNDRITVCRLAPSNIGDSCQRDCKPPLLCRDGKCECWGGSVVNGKCVVPCPAGQQLYGVECTRVAHWGQTCEKESHCVDPFTSCLGGTCQCAPGTARDLMRNKCYAVCPDNMHPHQSCRRLFLNDIDMLDNAATTDSCPIGFRCVTYGSPYIGHCCRLRCPYGEPDLSQSCDNSAPEDQKCRPLTHFCFTISEPGWKTSLCCPRPCRDPTPLYINGQCLSIAHRDDPCQTDEQCEGGVAMTCTLGTCECRPGFHATNDDRFPTCEKTCNIEEVAIVDKCLGKILLGERCVSNKQCPNFAECRFGICQCKCGFVQNDSLLGARCTNPDDPFSFNSILTNVEHLFGNKNRNSGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY22</accession>
    <name>A0A914XY22_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="4 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4 11"/>
    <dbReference type="AlphaFoldDB" id="A0A914XY22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12850.t1">
        <property type="protein sequence ID" value="PSU_v2.g12850.t1"/>
        <property type="gene ID" value="PSU_v2.g12850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="40"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="225"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12850.t1"/>
        </source>
    </evidence>
    <sequence length="529" mass="60909" checksum="AEAFCBD13F42ACAE" modified="2023-02-22" version="1">MSRALRRPSASEPLNAESVKFILESLKKSHCGFQGPHVFVLFGASGDLAKKKIYPTLWWLFRDKLLPENTLIIGYARSELNVGDIRKHFEEYCKVRKDDEQQKAAFEEFVNRNTYISGKYDTDEGFISLNNAIEQTEELYKKPAKRLFYLAVPPNVFEPVSAMISKHCMDKGGDAWTRVVIEKPFGHDDVSSKKLSDHLAKLFKEEQIYRIDHYLGKEMVQNLVILRFGNRFISPSWNREHIAAITISFKEDFGTQGRGGYFDESGIIRDVMQNHLMQILTIVAMEKPASLSPEDIRNEKVKVLKCIHPVTEKDIVVGQYTANPNGDNDDSRTGYLEDSQVPKDSITPTFATAVLHVNNERWDGVPFFLRCGKALNERKAEVRIQYKDVAGDIFVEGQLKRDELVIRVQPNEAVYMKLMTKKPGFGFEAEETELDLTYNSRYKNIRLPDAYERLICDLLSGIQYNFVRADELEHAWRIFTPILKTLEEKKTKPHQYIFGSRGPEASDKLMHEHGYIFSGTYKWTPPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYS1</accession>
    <name>A0A914XYS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12366.t1">
        <property type="protein sequence ID" value="PSU_v2.g12366.t1"/>
        <property type="gene ID" value="PSU_v2.g12366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12366.t1"/>
        </source>
    </evidence>
    <sequence length="406" mass="47040" checksum="2742395BC8368BEF" modified="2023-02-22" version="1">MANPAHAIFFEEAIEERALEPIPENISFTFGWVFSVPNADTDIRMIQTSFGTNFKAGACEWNVQLRLRQSPFSLSGFGGHPRRRAHHSMSQAHIMVETARNTKILGGSCRIAYTVYHDEDMRLELHSSPKVDAIASSGMITDGLRFRTPSGQYIEKLVAAFKKNEGKKIVVYIEMILPSRYFLRHFEETSIFAHRRLHGYPSDIEQDFRFDFSTNGDYTIKCPDGDLKANRQALYLSSLFFRNFLPSSHSKEFIVRHRIDAVKPIIWYFHSLCFEMPATYDFEFVRRIIDAIEFFHPISKLELMNGVHRSLCQKLADEESPNFDTVLRMASIASRHRFQELKNMACSLLANEFYGKFKAIFPQGEQNIANPQYRDLFMTQHFIGQTPFDYVEKIYRSGFRTNVIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ05</accession>
    <name>A0A914XZ05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12448.t1">
        <property type="protein sequence ID" value="PSU_v2.g12448.t1"/>
        <property type="gene ID" value="PSU_v2.g12448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111503" evidence="2">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12448.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10973" checksum="5526E113C5DE8182" modified="2023-02-22" version="1">MMFKQTICLLIVLTILSATLVNAAIVNVPSAFNNAVVTGAPGVKKPSGNGKKGEWRRRKFPKPVEKKNEDAKMDDDDDMGMDKRSYYGDYYYYYYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZG2</accession>
    <name>A0A914XZG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZG2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12601.t1">
        <property type="protein sequence ID" value="PSU_v2.g12601.t1"/>
        <property type="gene ID" value="PSU_v2.g12601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF4">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12601.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35667" checksum="27B3D32D5342F6B6" modified="2023-02-22" version="1">MHNLDQVLKGSQIVFVAFGAEWCPFSRRLKPIWEESAGKWAKDRPGTSVTWAFVDSVQNADVADKYFKTVALLREDCTFYSAIDQALQAVTENQIIFKVPGTDDEQKYAGSFTDYDFMKQWVTDKCVPLVREVTFENVEELTEEGLPFLIFFRDPKDKEGDKIFSELVMRELPDQKAGVNALLADGHKFAHPLRHLGKTAKDLPVLAIDSFQHMFLFPNMQELDQPGKLRQFILDLHSGKLHKEFHETLDQRIAELQKLALEQAEQFGEEAAKSGEAKPPAHLPPADTTPKPSIFKELKPSNKRYSILQKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZS1</accession>
    <name>A0A914XZS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12703.t1">
        <property type="protein sequence ID" value="PSU_v2.g12703.t1"/>
        <property type="gene ID" value="PSU_v2.g12703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="172"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12703.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24474" checksum="43C6178FEF0C62A2" modified="2023-02-22" version="1">MPLTTKNEITLEKSPAYFISKSVPERVFKMNPKMKLIVVVRNPITRAISDYTQAVTRKKRSIFTSKFEELVACFNETSPSCQRGVNASWGAIRIGVYQKHLKRWLEYFPLSQFLFVDGEKLITDPASQIRLTEKFLNLEPVVKRKNFIHDPIKRFPCIKRNGGNVHCLGKSKGRQHPQVRPIVIQKLADFYRPENEKFFAMINRRFEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0E0</accession>
    <name>A0A914Y0E0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein argonaute-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y0E0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12678.t1">
        <property type="protein sequence ID" value="PSU_v2.g12678.t1"/>
        <property type="gene ID" value="PSU_v2.g12678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000005">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="9">
        <location>
            <begin position="214"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="10">
        <location>
            <begin position="503"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12678.t1"/>
        </source>
    </evidence>
    <sequence length="845" mass="94818" checksum="EF1ED2A7D673086F" modified="2023-02-22" version="1">MEGRSIVLKANHFKVGMPAANIHYYQIEIQPDKCPRKVNRDIVNTMIDSFPAYFHNLLPVYDGKKSMYTKNPLAFPPNINRVELEVVMPGDASVDRRFKVAIKYASTVSLGKLEAAMAGTLRSVPADAVQAMDVILRHLPSMRYTPVGRSFFSPPLAAGMPGGGGASGQYHSGDSKLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYRKMPVIDFIADVLELPVQALIDRRPLSDAQRVKFTKEIRGLKIEITHCGQMRRKYRVCNVTRRPAQSQTFPLQLENGQTIESTVASYFKEKYNMTLKYPHLPCLQVGQEQKHTYLPPEVCEIVSGQRCIKKLTDTQTSTMIKATARSAPEREREISNLVRRAEFTNDPYAQEFGVTIQPAMTEVKGRVLNAPKLLYGGRTKMTALPNQGVWDMRGKQFHTGIEVKIWAIACFAPQQFVKENDLRTFTSQLQRISADAGMPIIGQPCFCKYAVGVDQVEPMFKYLKQTFTGLQLVCVVLPGKTPVYAEVKRVGDTVLGIATQCVQAKNVIKTTPQTLSNLCLKMNVKLGGVNSILLPTVRPRIFSEPVIFLGADITHPPAGDSRKPSIAAVVGSMDAHPSRYAATVRVQQHRHEIISDLTYMVRELLIQFYRNTRFKPTRIILYRDGVSEGQFLNVLQAELRSMREACMMLERGYQPGITFIAVQKRHHTRLFAVDKKDQVGKAYNIPPGTTVDIGITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNNLSADELQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDREHDSGEGSQPSGTSEDTTLSNMARAVQVHPDANSVMYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0M1</accession>
    <name>A0A914Y0M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0M1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1233.t1">
        <property type="protein sequence ID" value="PSU_v2.g1233.t1"/>
        <property type="gene ID" value="PSU_v2.g1233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037297109" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1233.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12300" checksum="A50CF15DA1A83F85" modified="2023-02-22" version="1">MNSQLIFLTFIISITFTLAQNNLPDDDYNDDPYNPTSRDFTARCNDIAEYAGPNACKAFMKCCSEDFSLNRLNGDRCQVADSNNACTLKADVSVYSLVNRPQFIISKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y155</accession>
    <name>A0A914Y155_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y155"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12955.t1">
        <property type="protein sequence ID" value="PSU_v2.g12955.t1"/>
        <property type="gene ID" value="PSU_v2.g12955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12955.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21688" checksum="705F0D519943F92C" modified="2023-02-22" version="1">MIPEKSATQILWQISDGMEYLASLGILHKDLAARNILLSQRLEAKITDFGLATITATSSCSDETSKFTYEAPIQRRLPLRWMAPEALKNRSFSEASEVWSFGILAWEVFSKGEIPYGTFDGNDILEYILAGNRLKIPEKVSEDWKTLLLKNCWSEKKEARASFKEIKSKIGAFLESQTLSYGYLITTFDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1U6</accession>
    <name>A0A914Y1U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1U6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11789.t1">
        <property type="protein sequence ID" value="PSU_v2.g11789.t1"/>
        <property type="gene ID" value="PSU_v2.g11789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11789.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21133" checksum="2F3D336DC9C9454B" modified="2023-02-22" version="1">MRYKIFLHGFGIFLFILSIIIYFFVFQRIYQPNYDLSYYSKLPIAEIPLIKAGTKFFDSPLLENMGIKTGLLKDCPKQCNFMDEKMVILKTKVDITLLHARDLKDEKLEEIKYASNMNFLGTKVLYSIESPLYTPVNGFNNDYIITYHSNSYGLLRKYDFFERITATSGATDVWSDAQYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y221</accession>
    <name>A0A914Y221_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y221"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14227.t1">
        <property type="protein sequence ID" value="PSU_v2.g14227.t1"/>
        <property type="gene ID" value="PSU_v2.g14227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037173410" evidence="2">
        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14227.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14089" checksum="F12EDC5EC1A2376C" modified="2023-02-22" version="1">MYRCLLLSLFVGLQSFHFSNGACKNGIPIIPKLSTTSTTTTTTLPPTTTSTTTTTTTTTTTPAPTTTTTTPAPLACSTCGNLPFAPPPQGYQTVQSDGIISQSINGAGCKQYVVTCYAFGAKYIVIGVRYSFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2A5</accession>
    <name>A0A914Y2A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2A5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11934.t1">
        <property type="protein sequence ID" value="PSU_v2.g11934.t1"/>
        <property type="gene ID" value="PSU_v2.g11934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF79">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11934.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30039" checksum="71315F3CAF80D10C" modified="2023-02-22" version="1">MSEAATDSPIIFDDSLAIEESVEISVADVTDEIETIEIDDSVTVDANTTTTKKKPIKSNIPTVLPLSKVKKICKLDPEINLVTADAVKLITFCTERFIELLAKSCVSCAKEQGRKTVSNADFHRATRRSWLFYMLDEAIDEWPDNGPPTKRSKSAASNRSNDDDGKDIDEAVEDEENDLIVDEEVAADTEEVIEDDEIIEIDTETIEVERDLTSVEELPMEEEEDVAPEIEPSNVVEEEEEESSEESDIENHDDTINDESFVKDIEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2A7</accession>
    <name>A0A914Y2A7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y2A7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13588.t1">
        <property type="protein sequence ID" value="PSU_v2.g13588.t1"/>
        <property type="gene ID" value="PSU_v2.g13588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13588.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16695" checksum="2998A58D52055118" modified="2023-02-22" version="1">MKKTNLLTSQKFRNIVFVSLAYRQAFFGVSNFNHKLNLSTDLNCGFHDLIHGIKWVKNEIHQFGGDPNRLTVMGDSGGASNTRVLAMSPQTKYLINQIVLCSVASDYVLVRDKNQNASRISAKIAGCANFLPNSSKWDNLEIVEKRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3F3</accession>
    <name>A0A914Y3F3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BolA-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3F3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14718.t1">
        <property type="protein sequence ID" value="PSU_v2.g14718.t1"/>
        <property type="gene ID" value="PSU_v2.g14718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050961">
        <property type="entry name" value="BolA/IbaG_stress_morph_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229">
        <property type="entry name" value="BOLA TRANSCRIPTION REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229:SF2">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14718.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12705" checksum="01F708EC45646BC4" modified="2023-02-22" version="1">MFVTRCLRNMTSRTEIIRNLLTEKFKPTLLEVKCESDQHNVPKGSEMHFYVGVISDEFNGLSILQRHRQISKLVYEQVPGIHALRIHAKSPSEVSDLSDAPDAPKCLGGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3I8</accession>
    <name>A0A914Y3I8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable transcriptional regulator ycf27</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">OmpR-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probable promoter-specific protein mediating the interaction between DNA and RNA polymerase.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3I8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13797.t1">
        <property type="protein sequence ID" value="PSU_v2.g13797.t1"/>
        <property type="gene ID" value="PSU_v2.g13797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17618">
        <property type="entry name" value="REC_OmpR_PhoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000001">
        <property type="entry name" value="DNA-binding response regulator PhoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111:SF40">
        <property type="entry name" value="PHOSPHATE REGULON TRANSCRIPTIONAL REGULATORY PROTEIN PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="REGULATOR OF RPOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13797.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13862" checksum="9FC46380F44A6D54" modified="2023-02-22" version="1">MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRDIPVVMLTARGEEEDRVRGLETGADDYIPSRFRRRSWWRESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y673</accession>
    <name>A0A914Y673_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y673"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14942.t1">
        <property type="protein sequence ID" value="PSU_v2.g14942.t1"/>
        <property type="gene ID" value="PSU_v2.g14942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037295897" evidence="1">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14942.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8640" checksum="7319DFBAD179C98D" modified="2023-02-22" version="1">MKLFVILAFCACIFVSVQAFRYPFFLNGASDNAKEAFMNIVTKDGLTPTQKEAKIAELVSQLSESVQVWLPTSYKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6L8</accession>
    <name>A0A914Y6L8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CNNM transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6L8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15837.t1">
        <property type="protein sequence ID" value="PSU_v2.g15837.t1"/>
        <property type="gene ID" value="PSU_v2.g15837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="3">
        <location>
            <begin position="161"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15837.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23656" checksum="674E4903F9BCFC70" modified="2023-02-22" version="1">MLILSLRRLANIDIIVTGALNAGGFITTEKKAQLSGLRVETEAGEEGFIGYTERGVSIVHPDIEVRIVLFGWWLDEVQTFGFTLHDNCSQTPTNVSQADFTIQTEKRVVIKYMFESTKEIFKICMKQKPRESKNGDLIEQQYLLVDDLRTSISTDIPPRKYYFHMGIQIAIISVLLVCSGLFSGLNLGLMALTPQELMLISNSGKSEYKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6M3</accession>
    <name>A0A914Y6M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-54 factor interaction domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6M3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15846.t1">
        <property type="protein sequence ID" value="PSU_v2.g15846.t1"/>
        <property type="gene ID" value="PSU_v2.g15846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32071:SF117">
        <property type="entry name" value="PTS-DEPENDENT DIHYDROXYACETONE KINASE OPERON REGULATORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32071">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15846.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21941" checksum="6C525278358A98A9" modified="2023-02-22" version="1">MLQAKLLRAIEAREILPIGASSPIQVDIRIISASNQNLAQFIAEGKFREDLFYRLNVIPITLPPLRERQEDIELLVHYFLHLHTRRLGSVYPGIAPDVVEILREVIDSTLLPPNLLNNGTTEQSDVTEVSEAHLSLDDAGGTALEEMEKQMIREALSRHNSKKLVADELGIGIATLYRKIKKYELFKHITSVNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6U8</accession>
    <name>A0A914Y6U8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6U8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15934.t1">
        <property type="protein sequence ID" value="PSU_v2.g15934.t1"/>
        <property type="gene ID" value="PSU_v2.g15934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15934.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="18894" checksum="BA9D8061017A1613" modified="2023-02-22" version="1">MDTVADNPTLPSFVDNYYEPWNQANPGAEKIYESSDKNAVPSPQLSMPDNQCLIIPEPANTDKSNQSPKSAITDEHEKFVKNPLSDQQISDNFDKNSKVIEAAHEDIESILDKVIDIKPLSSPLPSSSSSASTSNNITTNNDNILSPLSPSSNLNILDGCADSDDKVNSINVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7P9</accession>
    <name>A0A914Y7P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7P9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16226.t1">
        <property type="protein sequence ID" value="PSU_v2.g16226.t1"/>
        <property type="gene ID" value="PSU_v2.g16226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16226.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19545" checksum="7DFE55237562E94A" modified="2023-02-22" version="1">MALFSRLAVSNCGWNALVDYLVIPTVSNLKFWRAIPRGFFTGKEWKQTIETSEGAYCRAFECFIQFCLAMASNLYWRTISCPLLEAIEANQELTNQLIRTHPTLSLTKNIALLVFYIHSLDDNAKEPIETTKCLNDFLLLHTQGAPTTGYELTNLPTRSAFNLPLNLFSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y805</accession>
    <name>A0A914Y805_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y805"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14881.t1">
        <property type="protein sequence ID" value="PSU_v2.g14881.t1"/>
        <property type="gene ID" value="PSU_v2.g14881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14881.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15051" checksum="77EB1E05A7D93DD9" modified="2023-02-22" version="1">MLSSPLKSQKIYLSDFTLMVFDECHHCNESHPYNVVMNHVRGSKICPQIVGLTASTGSGRAKGGKINPEDTLNHIIALCARLMAVTISSVKIKQNVEDLLSTISQPVDGKYFVYKVTVLIYIFLRFYCCSTSFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y824</accession>
    <name>A0A914Y824_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y824"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14900.t1">
        <property type="protein sequence ID" value="PSU_v2.g14900.t1"/>
        <property type="gene ID" value="PSU_v2.g14900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF48">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038032304" evidence="5">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14900.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16965" checksum="40151C22FCA058B4" modified="2023-02-22" version="1">MFKLTLLIFIVTIFGAVVESTVDAGISTRSAEAKGTLMCGNSPAAGVKVYLKRELSTDIEEIIGHSVTDDQGKFTVNGNTERYGGSKSTIDPVLSFYHKCDKADAKSFQIFHLRFPRTYVTIGRISRRPYDIGTFNLQIKYPGQSEDKIAPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8B7</accession>
    <name>A0A914Y8B7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8B7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15518.t1">
        <property type="protein sequence ID" value="PSU_v2.g15518.t1"/>
        <property type="gene ID" value="PSU_v2.g15518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053287">
        <property type="entry name" value="PP2C-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586:SF0">
        <property type="entry name" value="PP2C-LIKE DOMAIN-CONTAINING PROTEIN CG9801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586">
        <property type="entry name" value="TIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15518.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="30808" checksum="D1C40BCFE3112082" modified="2023-02-22" version="1">MRQQPIVRMANLDDELSLSSYEEDGDGEGEDDDEGDGRTARLNISADAGMNPSHSMEALGFHPTDLAPCCSTDTFDWTTCNPLRSFGASTSLYEKHPVTGMNAGTPIADVFGIISRENNAIIALADGVNWGEGARLAARCAIRGALDHVNAAVEKDSFETTTDVFHCMLGAFHAGHSLILQEGGALTTLCVAFVAPIKNSDNYALCVANVGDSLCFVYNHVSGVREVTLASHDIAQMRDMRDAGGALGPVDGRNPQLHNLTCSMTFVQEGDIVNCTKNKVRLSHTDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8R9</accession>
    <name>A0A914Y8R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoinositide phospholipase C</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8R9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13977.t1">
        <property type="protein sequence ID" value="PSU_v2.g13977.t1"/>
        <property type="gene ID" value="PSU_v2.g13977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF159">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13977.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20430" checksum="4C584EE5AC587C2E" modified="2023-02-22" version="1">MVALNYQTPDLPMRLNQGKFLANGGCGYILKPAYLMDPNFCYKDPETLNGKNFPINLKVEIIAGRHLYRADQSKGICSPSIKVEIIGLPFDDKSFRSTSINSNGLNPLWQETFEFEILCPEMALLRFHVEDGDYVGAKMDPFIGQAIFPIDCLRGGYRSVPLLNQSAEPQELAALLVHLEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9V0</accession>
    <name>A0A914Y9V0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9V0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14304.t1">
        <property type="protein sequence ID" value="PSU_v2.g14304.t1"/>
        <property type="gene ID" value="PSU_v2.g14304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14304.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14355" checksum="6422719C4FAA4EEF" modified="2023-02-22" version="1">MILGDSIIYYSYKRSPKEGCCQLDPNLFNCILGLICDGYGLNKDSQKDNEKDKYLRECIAEELNITARKVFKNAADPQKFKSSNQFGIIEPPSSTPQSRPHSNITVSVKAETEPDPPVYCIDSDEDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9W2</accession>
    <name>A0A914Y9W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9W2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15550.t1">
        <property type="protein sequence ID" value="PSU_v2.g15550.t1"/>
        <property type="gene ID" value="PSU_v2.g15550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052079">
        <property type="entry name" value="E3_ligase/Copine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751">
        <property type="entry name" value="COPINE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751:SF48">
        <property type="entry name" value="COPINE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="329"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15550.t1"/>
        </source>
    </evidence>
    <sequence length="563" mass="61788" checksum="75AB649EF8374808" modified="2023-02-22" version="1">MIFNPFFCNIGQSLDGPGENVAPQGPGQKIDEPDDDPKRLACADIYIQDAIDYIESQRPATSHSNNGGGFIIEEDMLESDKISPLPPKDFPSGPNLSELEKQLQSPSEAAAAAAAKQLSSQQNISADPTSKMIRTNEVFTRPEPSFDDADDAITSAPEIQSIEIPPDQMSENSSNIMDNYDFRPGSSGAYSPPLLKFHAEPSLPGTNNNNLINNNPSTRNVNFELDSDRLMAISPSSPRPSSQTSSFSRHGGSSSHSPAPAPEAPQLWRVSPVPYDETPSLSISERHVYMRKQSSLLSVLHVTSMQEMLLTLTNLEDLAAALRKAGLESTNIIFGIDYTASNKYQGENSFGGKSLHSVNDSSIENPYQQVIRIMGHSLASFATAGSIPVYGFGDASTGDWSVFKLKEGSECQDLEEVLRVYNEVTPKVELSGPTNFAPLIYEAMKICQRIQDYHILVIIADGQVTNERATRKAIVKACEYPLSIIVVGIGDGPWNLMRVFDESLPKRPWDNFHFVEFNEIVREHERSSTDNELAFAIQTLLEIPDQYAMIRRLGLIGGGSRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAA9</accession>
    <name>A0A914YAA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16364.t1">
        <property type="protein sequence ID" value="PSU_v2.g16364.t1"/>
        <property type="gene ID" value="PSU_v2.g16364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16364.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="18745" checksum="013CE1B0475A4860" modified="2023-02-22" version="1">MEYKKGDSVIAAVAWMIIFGDGLHNFIDGVSIGASFTESLLSGFSVSVAVIAEEFPHELGDVAILVSAGMTLRQALVYNLLSALSCYVGFAIGALFGNLDENFAPYIFAFAGGMFLYISISCMIPEMKKAMEEGLQVSLKNGLEVFILQTMGIISGLCLMYTMARYGSNIIISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAL3</accession>
    <name>A0A914YAL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAL3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14541.t1">
        <property type="protein sequence ID" value="PSU_v2.g14541.t1"/>
        <property type="gene ID" value="PSU_v2.g14541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14541.t1"/>
        </source>
    </evidence>
    <sequence length="347" mass="37156" checksum="30FC522717C668C2" modified="2023-02-22" version="1">MFIGSYAAGFVPLAFTFSESKVRLLSILGAGLLVGTALAVILPEGVEALQPKHSHVSPHNSHKDTHIAKQILEESNGENDAHPPRIVPKDAEMHADVPMDVNAHGDGGNSQPKREKRQAHAEFDKETDQQVHTEETHHEHAEIGPTIGYSLVFGFILMLLVDQITKSKQTGRQRLTATVGLVVHAAVDGIALGSASVVNKSDIQLIVFVAIMLHKAPASFGLTTILMVEGLERSKIKKHLFVFSSAAPVGALLTYFLIPKGSIDSSSSTTGIMLLFSAGTFLYVATVHVLPELASRKSESHLPLPTSPSSSTSTHSHQNGADFTCKELIILIIGSLLPSLLASGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC15</accession>
    <name>A0A914YC15_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16300.t1">
        <property type="protein sequence ID" value="PSU_v2.g16300.t1"/>
        <property type="gene ID" value="PSU_v2.g16300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="241"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16300.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32516" checksum="C22A3FB5A66D4331" modified="2023-02-22" version="1">MNTRNGHQRNLSENSEADDLFNFDIKKDKTPKRVNTNSGQRPTFGDLKFFNITPNNSANMDNEELLLAPALLTKTPLTEVPKSETLKTPTNKSGRRTPTLRKRKASEDAETPAKLAKVDTDDAFVTPKATPAARSSVKRKLLKIDEEMPVLQAEEQLSDSVTAVNDQENVSQSGGRPRRSAAVKAAAAITLAATPSTSSITTPKTKSRPKSKKEDTKVVEEESSSRGTSELDEANREGDIAYDKIFNELQFILTSAARNSSSSTFVKKEVRKQIESRGGNVVETFESMNPDLTTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC44</accession>
    <name>A0A914YC44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YC44"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17784.t1">
        <property type="protein sequence ID" value="PSU_v2.g17784.t1"/>
        <property type="gene ID" value="PSU_v2.g17784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052854">
        <property type="entry name" value="Serpentine_rcpt_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47518">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS EPSILON-13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47518:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS E (EPSILON)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17784.t1"/>
        </source>
    </evidence>
    <sequence length="534" mass="61846" checksum="0104715E3FECDA13" modified="2023-02-22" version="1">MRLIVAINELISANFVAISDISINYMIISGTNEYTVFGLFRLAAINAVLSTLGTIVFERIYATVYLETYEKTVSNPFFFYCVLYHALEYCIATFSIYQEWIDLAIFGTVIIILNVIGYLMFTCLEWFNLRKYRTSLAHRKRYTLSERFQLQENIRTAHLMKHVAGVVVFLDILVGSAMIISRFYEFDEIAKDETRIDTVSSSQSPYGLRKRSSVSYVENTFEEVDGEEEDNEIEKGDDSDTHEQSETAPSRSSYGLRKRSRVSYFGNDPARHGVQQKDEKKKPKNHYSCSNFELRTLVHGYKHLFIFPSDDHSTCYRFTPDTNKRFTCSQCFNVFKITSSAWLKRGPGGVEFVEMIEGHLCEPLKYYESNVQRITNFEEYIDEYKKELFVFGSDDKSTYYRYCYHKDKYVCILCNKMKKVTEAVVKSENGETVVEGETIHACQPIPYIQKIKVPDFELRQNVNGNPQLVIFDLEDRSLCHQFNWHKTQKVFCCFRCISKTGTLASASVKKLPSGEEFVQQYNPHGCSPIAYVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCW7</accession>
    <name>A0A914YCW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysosomal-trafficking regulator</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g17135.t1">
        <property type="protein sequence ID" value="PSU_v2.g17135.t1"/>
        <property type="gene ID" value="PSU_v2.g17135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF86">
        <property type="entry name" value="LYSOSOMAL-TRAFFICKING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17135.t1"/>
        </source>
    </evidence>
    <sequence length="1301" mass="150810" checksum="F3D827EFA7E9ABCD" modified="2023-02-22" version="1">MEPEFLKTLLSTTELWKFEYFRYWAKLVHLTATTLDTCKAKFCEFNSQILHRVDFLTPLLHALLDMFSNKNLFSATSLAHDLTEIYESRDPLIIVSKSLVSSVCTIISELVSSPYRCPAVVQLWNFILLSHPAQDTYLDYTLKGHAEWVRPEDIESSAADEAILEPQNSLLSAFFEKVLMNFDKDKIAELWKETNSATTVRKEILKSENDYRIFAPSAMRLDSLICDQQHPDNKDYWSSDDSAAQFEPSVTKSVDHWLITLRADLISSMCHILLACEDSLMAVIELDVITWKTIIVQLTNQTHLRIRNLIFLLLQNFFLRCTDKYRQEFIKQHGFLILANHLRRLSVTYEIADSLFSIFCGECVKILDGLDEEHLEKMETTCFRYASFHGLFALLEASVTDHALFWTVCSTLQKIFVANNLFRRAMIDCGIVDTMMNVLRLLCVEQPSVQTMIGPVFPLLDCWISFSRSIINLVIPCRDPYMYSRSEDFIWLCQIADYQLSNSVASTTPSERLRKFSSLTAPPPSKLCSNCAKQMVRRALSGLLDCWFDSIQSVVVDSSKMIPVDERYDDDNEDSESDSSAFEIYYGDSHFTSTSYYGDETKAERRRRFEFANAEELSKRLSFGLEMANNLFVFGQIPESMSEKEEMLFQSYIEILLAPWKKRQTGEYHEEWYNVLLGCKERARVLLAQLIAYVLFPVQVRQKQLFYDPLAAPIIDEQGLLRRRLLIVKLLTAELSNNKTYLESLLEVNLDYQYAMKIALHELALCPQYYEIWDEYSEDLERMIKFLRACQLESPLANLTRDEVRSLTTDEVILLHTFKEKRSKFVESLKKESLRLMEKDNSLVKAVSDNAMILTCSIAELQNEPRKFYIQSRKDAINACAKANEVLANLVEELCHPEAPFFDESSWPKGYSLDTTENLRRERKRLKPDHYRFEKKFLQKNRQNEVGDTVTNLAPLQRLRESCPNFATTDYIEASNAVRLSLSANLIRTNWTCSGEIIISERKIHFLGEEAKSTQKGAKCSPVTFAWSYNQLSEIYYRFYLLKDTALELFTTTGDAILIVFATTTDRDMFIGQLKKMGLGHLMADEENQLKLINQQWRRGNITNFDYLMTLNKLAGRSFNDLMQYPVFPFILSDYRSTILDLNASQSFRDLSKPMAIQYKHMEDYYIQNYESLAEENKRTRREGETFYSSMFGAYHYGSHYSNTGIVAHYLVRLSPFTNVALEYQDNNFDIPDRLFNSLDTTWRLSASESTTDFKELIPEFFFLPEMFCNREKLELGTRQAGIVVDNVELPPCIRIPTCYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD85</accession>
    <name>A0A914YD85_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g17259.t1">
        <property type="protein sequence ID" value="PSU_v2.g17259.t1"/>
        <property type="gene ID" value="PSU_v2.g17259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF34">
        <property type="entry name" value="CHAPERONE PROTEIN DNAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17259.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47931" checksum="7170AB7BA1FAD701" modified="2023-02-22" version="1">MKLKKVLHRWSSGSERSSNGPTLAGERLLPSYVAFNEKNVICGKLVVTRLQNYPKSTVFDSKRIIGRNINDLEIDSIWPFTIISDNKNNILIKVKGPNGNENKTAEEVSAELLKHIKKEAENSHGEKLSKVVITIPADFNEAQKEATFKAALLAEWKEIKLLPEPIAAAFAYFIDSPMPTNSTVLLFDLGGGTLNICIFKYQNFDQIQIISNIGDSKLGGRNFDTVLINHFAEILDRKYGISMASNDKKYKLMTECQEIKETLSVIEGTSLDVDIFDPSLNQEVIQINREEFQRMTQPLLNKIKNILSLALTSTGIGANEIEKVLQVGGGSRMPMIKELLIKTFPFAVQSCHKHPDEVVAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDR6</accession>
    <name>A0A914YDR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDR6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17441.t1">
        <property type="protein sequence ID" value="PSU_v2.g17441.t1"/>
        <property type="gene ID" value="PSU_v2.g17441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548689" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17441.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10519" checksum="EAB0396DAF39DE80" modified="2023-02-22" version="1">MASLLSLIILFLALIAAITAAALPAFQVPGINLFEPNDGPVIEKRVPHPSWRSNVRINHIQHHDGSPHFNNYENGQARSFYNQWAFRPFQQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEE6</accession>
    <name>A0A914YEE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome activator Blm10 mid region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17671.t1">
        <property type="protein sequence ID" value="PSU_v2.g17671.t1"/>
        <property type="gene ID" value="PSU_v2.g17671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17671.t1"/>
        </source>
    </evidence>
    <sequence length="536" mass="61018" checksum="BDE48A2F09589157" modified="2023-02-22" version="1">MQSCGLSVGGNQLGTDGTNVQLTATLIAFTLGGQNDTVQEKLTSLLNSWEDFFHPSNFGGHVSNLLTFLAKLVANVVNRVSRERYFPNRHYVRIPQEQQLTDIQLDTFVKSLLPCLHYAAFAKSKHDISRVFRHCAFLAPGIVLPTLLDLLYPALETVTEPHRLLQSLNIMMNVLVPLARDEPTPGRERFNMKLLEGVENNQSLRSHFITILNNILPGMDVNDSTKSALTFQIIATIFALMPVVDCSDAPSECEDLTEEERELCSATAGLEGIIDQVLQKCFSVIETYGSVFNPANTRQFSMEHSVQKSTEELLSERGLYVIFRSLTKNCSTQIYKQALHSFFDFMKDHVFDSRTALESICRIASIFVNVNPRYAFPIFFNYAWENLQKVTTEESLKQEELNISTVWYYSLLCELLQRVRGDVVVELKEQILPVLHVLLQFHCKDAFLRGVYALEGLLYSLTSVYSDMEEYYLNVNDQAFDKYLPIRNWAKTVKKNNWTMKWHVPSPEEVALTKDLLDTYMIGSLKQLQSPGTLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF47</accession>
    <name>A0A914YF47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF47"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17383.t1">
        <property type="protein sequence ID" value="PSU_v2.g17383.t1"/>
        <property type="gene ID" value="PSU_v2.g17383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17383.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27502" checksum="DB4CB19C1D78F1D5" modified="2023-02-22" version="1">MEEDGAAAFDFCGFSDTDEAITLESTSTAAVFNYDEFEQSGYISLDPENDLEHEKEKSYLQILEGLHENLKNATNSMILRLYENFLANKPDHLHPPKIEDVLLKPCCGNYCGISFSPESIMRARLLIPVVAAKERVYSVVLDFHFMLLKLCINGTQLTPKIGNLIVCAEFFRRVYAIPYGRYNRLCNQVLMNFTRPVPHGNEDRIRTTVSSLERVGTLVNILATVAEPLPDGNGYILPSSMTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFT2</accession>
    <name>A0A914YFT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFT2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17617.t1">
        <property type="protein sequence ID" value="PSU_v2.g17617.t1"/>
        <property type="gene ID" value="PSU_v2.g17617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17617.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="43908" checksum="6456CF74316EBDFC" modified="2023-02-22" version="1">MGFYENTPINLFNDLCFDLMSRRRFFNLKRYSIHVVDKLFNSSTTDLCQLPQKSVDHPLFEQLIGIKSEVFQHICQDDRLFHYLLYSLGTHCMKSKIQCDVLYSSLYLWYFNSVLSYLLPDNDSALICLKKFDWFSAINKLSTLKSALRLIKRQVIAANYSPNLFARTDGFQSPYPRVFDFSKFMIECLSDRNAIPYEGQVVTLKHMVLYYMNFLLASTNDADFNCFKEKLRGFNWVTTRVKPILVRWLQNRALDDLYMELVDFWACLVAPDDRLKTREQFTKFFQMFSKEFGDIFYIIMDRCLNADLRIPSHVKFLSFIVDHVFSPVMILWYQKMGFAVDDKMTQIQNKIFKYQVELDVKEMQKVVSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG27</accession>
    <name>A0A914YG27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG27"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16298.t1">
        <property type="protein sequence ID" value="PSU_v2.g16298.t1"/>
        <property type="gene ID" value="PSU_v2.g16298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="196"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16298.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41367" checksum="9F951A0097634C8D" modified="2023-02-22" version="1">MEPVKFDKIKNEFVVVKHDEKQKQELCDFAISINAECKKVDFEETIVRIPYTLFIPDYNLRDLNVYEYLEGVICLQDGLKFTYYVNKSKEDKVEIIVKNEYLAEISDKKSENQPLAKKQKTFRHQACDFKDLELTLWFMFNKADIKSLKLEKENDKIIDKNQEDEKDEECLNEPDFVMLKNNTAPKSMKKLSLYDVMSDTKYSDVIFIASNGVEVPSYRCILSKYSKYLADHFEETKLLPVKINAEEFTENTIKAAIEFCNGKNNASTGKEIVIYDFAEKFCFEKLKEICLLNIESQLNLENVYEVIKIAYSKDLDSLKKLCTEIMRENKGNLDPSKLFKLPRKIGDDLNLFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG53</accession>
    <name>A0A914YG53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17747.t1">
        <property type="protein sequence ID" value="PSU_v2.g17747.t1"/>
        <property type="gene ID" value="PSU_v2.g17747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17747.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="22119" checksum="7951F6DFFC779BB3" modified="2023-02-22" version="1">MYFSITYIYFRFLGLKPALEEELLNLSDGYEVWSRFNSFLQTETNIAFDKLKAYFMSERQKLIKVALALMFQQHRAVLRVLLETEDALLVYCARFSTIESELCCGLRERDFRRVFQESQSDVRELVEFFLKPQAYRPPYVGGNRLGLILMELRRQFILGGCYPSQYEILPMPIESKLGTDSPTENYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGH2</accession>
    <name>A0A914YGH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18417.t1">
        <property type="protein sequence ID" value="PSU_v2.g18417.t1"/>
        <property type="gene ID" value="PSU_v2.g18417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18417.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12621" checksum="C97390BE6FDC207C" modified="2023-02-22" version="1">MKEAAKLHYNDADRFFSKFSDCLKTHIPINDTQLDFFNNRVNDENKVFLTMAEGYQQKTCKWLTAGIGGSSRAEELVLNKYSNCEIYGVDPTNVGNFSKIGKVLPFGVGKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGJ7</accession>
    <name>A0A914YGJ7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Metalloendopeptidase</fullName>
            <ecNumber evidence="14">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A914YGJ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19427.t1">
        <property type="protein sequence ID" value="PSU_v2.g19427.t1"/>
        <property type="gene ID" value="PSU_v2.g19427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000045">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF827">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038156022" description="Metalloendopeptidase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="16">
        <location>
            <begin position="73"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19427.t1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40647" checksum="22E4927293FD6264" modified="2023-02-22" version="1">MLHFLSILLITVVFHGTNAEISDGTALTDEDFSNADKLTKKDIYKTNVPIEAVNGYKSDIRGPERDKKRFRRNGVSRPTKLWPHARIPYAISPHYTTHERALLARAVKQYHDKTCVRFVPRAAGEGDYLFIGKVDGCFSEVGRTSGVQVLSLDNGCMEYPTIIHEMMHVVGFYHEHERWDRDNFIDIIWQNIDRGALDQFGRVDLSKTSYYGQPYDYKSILHYDSLAFSKNGFPTMLPKKPGLASTIGNAKDFSDVDLAKINRMYKCERQIPDSLRTIASSPKARVSPIYAPPLWKSVNRPHLEGHAFYDEKEKTQKVCEDRITVCWWTQDRCLSPNIYLMMKSLCAKTCRFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGS8</accession>
    <name>A0A914YGS8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
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    <dbReference type="WBParaSite" id="PSU_v2.g18660.t1">
        <property type="protein sequence ID" value="PSU_v2.g18660.t1"/>
        <property type="gene ID" value="PSU_v2.g18660"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="33"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18660.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25934" checksum="156A7B6C875946E8" modified="2023-02-22" version="1">MAKFVVTFLYVNRTPACIDVTKLFEENGLLAAIPDITVSACKVNHTSDAGGYIITTKGSKSRKLVFSGDTTPCDLLIEAGKDADVLVHEATFDDDREIEAQKKRHSTMRQAVNVGKAMNAKHIILTHFSARYPKVPTLPQYLDENNVGISMDNLVVSMDSLPKLSKLNEIWRIVYEEELFNIETRNYAKGIKALKDSVTTTTITAAATEDDTATPPQPLSEPPAKKRAFGNNGDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH28</accession>
    <name>A0A914YH28_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18091.t1">
        <property type="protein sequence ID" value="PSU_v2.g18091.t1"/>
        <property type="gene ID" value="PSU_v2.g18091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18091.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14481" checksum="DCCDFB9B6131C8E9" modified="2023-02-22" version="1">MTQAINDNATDGIGLGRPATQEFDLPNNLINGTFQSTPFWRFGDDFNAALFACACQMSQAGLTEYFPDRGVNYGIMDLSNDKTFEEYQNAYNEFIKIITKKGEAGKFYFGIVPYQLNGRAIICEGAVSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH73</accession>
    <name>A0A914YH73_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18139.t1">
        <property type="protein sequence ID" value="PSU_v2.g18139.t1"/>
        <property type="gene ID" value="PSU_v2.g18139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18139.t1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42201" checksum="B7B9AECAD8103BAF" modified="2023-02-22" version="1">MKTGAVDVFPTERMNIEMAIKILETKFNKENLCEVFIYGLSEINKIVLEVLTHKLPLPQMYVKCRDIATLIAHSFITYPTKLLFIFHQLFLTHLDIDALVVYSVLCRYVNQVFKIANVLREFSAPHLNEINTRFVDTIKQNIVDPFREMIYKVDREFLSKDVVVVALVCNDIGSDQYLDFQKLMLWFNTGFRKMGATVESLTLSADWNNPELLQISAYNAIAMVQSYFKFIIETYPSSKLIVVNYGDPSMFFYHAIHFVERISGVINIAFSTSTFVDEVEHIRGGVEDSILNMTYCPSLFVTGEKAEKSDISHYDQILKHYKTEQAGLIIVGDADDVLNVSSKTLLQYRITPACVKRILLVSLSFINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHF8</accession>
    <name>A0A914YHF8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylglycine monooxygenase</fullName>
            <ecNumber evidence="1">1.14.17.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O</text>
            <dbReference type="Rhea" id="RHEA:21452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13486"/>
            <dbReference type="Rhea" id="RHEA-COMP:15321"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
            <dbReference type="ChEBI" id="CHEBI:137000"/>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
            <dbReference type="EC" id="1.14.17.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="10">Binds 2 Cu(2+) ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="1.14.17.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YHF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16742.t1">
        <property type="protein sequence ID" value="PSU_v2.g16742.t1"/>
        <property type="gene ID" value="PSU_v2.g16742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004504">
        <property type="term" value="F:peptidylglycine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014783">
        <property type="entry name" value="Cu2_ascorb_mOase_CS-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000720">
        <property type="entry name" value="PHM/PAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00790">
        <property type="entry name" value="PAMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00085">
        <property type="entry name" value="CU2_MONOOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0186">Copper</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="13">
        <location>
            <begin position="145"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="166"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16742.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33852" checksum="3A2902077521004F" modified="2023-02-22" version="1">MPGVTLNTNETYLCSTFQLDLQDTHYLLEFEALADAKHIHHIILFGCDEPGNDAKVWDCGEMTAEKNSEYQQSPVCKNNPEIIFSWGKNAPKLELPEGVGYPVGGRTKNQNLILQIHYMHEEPKEDYSGLRIVSTIVPQPRTAATLLIVTGGTVKAHSTVDFEAACVLDEPIVMHPFAFRVHTHSHGVNVGGYIVNENAMTKKDEWFLIGERNPQLSQMFAPVSNKSAIIQPGDIIASRCTMKNDENHDITVGSSGADEMCNFYIYYMVEGTQTLKDNTCYSPGYPEYRWSTSAGLNNIPKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHI3</accession>
    <name>A0A914YHI3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHI3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18777.t1">
        <property type="protein sequence ID" value="PSU_v2.g18777.t1"/>
        <property type="gene ID" value="PSU_v2.g18777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="74"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18777.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25834" checksum="5D3CE65F2A8F4022" modified="2023-02-22" version="1">MNEIANVRAFFNERHITLNSEWEDDAIGYVKAQLRNGDDILKLSKSVFVQWLNSDLRESTQPTLNVPANATGITVVKPALVQLTSILNISESAYSQYRSKIMDLTEDNSEFRDPSETSHEQVEKPKYGNIQPKKPPMYMYKLSDGNITLKAVIAETINGLDCNTPIGAKLLLIPKFLCRYRVLKLTSQNCQFLGGYNEQCIDKDDPLSKLLNRIENTENRQPPLISQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJL9</accession>
    <name>A0A914YJL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJL9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19716.t1">
        <property type="protein sequence ID" value="PSU_v2.g19716.t1"/>
        <property type="gene ID" value="PSU_v2.g19716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="166"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="259"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19716.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39012" checksum="A00CD6C194D44A4F" modified="2023-02-22" version="1">MDREALIHFIGGAVGGTAGTAITCPLEVVKTRLQSSKHGFNSSSSSSPNPPSGKPSTSQTNFPQKGSSKITLNGQRKLFTAFVNYGYPRFFELQRAYLHTSPKQASPFRPMLVSHFLNIVKSEGISALYKGLLPNVVGVAPSKAVYFYTYSSSKRFCNQLDIFVPNTAIVHMLSAGFAGFITATVINPVWLVKTRLQLHHGPLSIRECIKRIYQREGLKGYYKGVTASYMGISETIIQFVLYEYLRAFIDDYHYLNENKKFLNFMLAGGCAKFFACIIAYPHEVVRTRLREEGSNSKGFFKTLKALYREGRVPALYRGLSVQLLRSVPNTAITMGAYETVIYVLHQYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK28</accession>
    <name>A0A914YK28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19678.t1">
        <property type="protein sequence ID" value="PSU_v2.g19678.t1"/>
        <property type="gene ID" value="PSU_v2.g19678"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g19685.t1">
        <property type="protein sequence ID" value="PSU_v2.g19685.t1"/>
        <property type="gene ID" value="PSU_v2.g19685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19678.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19685.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8557" checksum="9030150F8C69607E" modified="2023-02-22" version="1">MSSRYRQTFTHLLVRAESWLRNRHDRRRLDRQIYRRAVLKTSPSFTLPSPSFAQLELARTPLTDEAVELISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL14</accession>
    <name>A0A914YL14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YL14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2023.t1">
        <property type="protein sequence ID" value="PSU_v2.g2023.t1"/>
        <property type="gene ID" value="PSU_v2.g2023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002104">
        <property type="entry name" value="Si:ch211-266d19.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2023.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18404" checksum="803A131E1C71B6AD" modified="2023-02-22" version="1">MLSQTSNSNFVPSSEYAARFRMLNLNAMAPSLAAFGQNQYNKAMIPTFPFIRPDGPPPTNHRLSLGSTNHFERLMSSSSLSSARSSCSSSAGSITNPSTTTSLPSIRSSNVKKYRCDICDKTFSRSNTLITHKRIHTGEKPFRCEVCSRAFRQPGNLTRHRLTHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLN3</accession>
    <name>A0A914YLN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLN3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2047.t1">
        <property type="protein sequence ID" value="PSU_v2.g2047.t1"/>
        <property type="gene ID" value="PSU_v2.g2047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037942822" evidence="1">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2047.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14086" checksum="A9C5E1A3CB039CEE" modified="2023-02-22" version="1">MEFLNFFIFAAFLFFGILAQRFQRHVNNTKLTVNGTLIDRLNNSFPDIPNELAADQLPGVQEGDDVRLIRPGGIEIELKYGELKFEFCSDGCLEKIVVVCFDCENCDLEVQGECGPNRCEFKAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLS5</accession>
    <name>A0A914YLS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLS5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18273.t1">
        <property type="protein sequence ID" value="PSU_v2.g18273.t1"/>
        <property type="gene ID" value="PSU_v2.g18273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030160">
        <property type="term" value="F:synaptic receptor adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06746">
        <property type="entry name" value="PDZ_SHANK1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="162"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18273.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="36871" checksum="9256A3F3AF5EDA6A" modified="2023-02-22" version="1">MSSSSSMMSMSLYATYGRKPPRPPPPLPLPLPFQVPVFIYDSNPSIPPKELKPISLISVPYRGAPKYNTRRRLTNPILRRRSLSQSSICSAQSERYQTPQNLLLRQQQHHPQMGLASPSPSCLTMCPSNSGSTGEYGTLRRYAPDAIPSAPRAGFEPNVPRILVIPRGPKGFGFILRGAKHVDSEVEFEPTPLCPALQFFEGVDMSGMAMKAGLRPGDFLLEINGVDVRCASHEQVVHLIHQSDDTITLKVITIDNNPNNNGNGGGHYGPGMNGTIQSRRNHSVPRNILPPMPPQRHPSTSLSFARGGPVQQSMGFSSKLFFLKGQWHFGILLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLX7</accession>
    <name>A0A914YLX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal lipase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLX7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20371.t1">
        <property type="protein sequence ID" value="PSU_v2.g20371.t1"/>
        <property type="gene ID" value="PSU_v2.g20371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908:SF5">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037941964" evidence="1">
        <location>
            <begin position="21"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="95"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20371.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41155" checksum="9B629BFAF587F363" modified="2023-02-22" version="1">MTRFLYFIFIFFIFIPNFLCIPIRQSRTAYNEVEARALLNLAAGAYANSPEACIKKTFLSVRPRQLHSSTNQICDEFANSCGSYSLADDINQHLYIVFRGTKSKAQLLTEGWHSLQPSRDFYGIGNANTYFFHALEALWPNVEQALVEYPNYAVTFTGHSLGGALASLASLKTVLFGLRSSNYVKLYTFGQPRVGNILLAQRHNELVPQSYRIVHGVDIVPHLPGCAKDEIMGASSHPCDPDNLERPYHHGIEIYYPHEMREDSPYFECLGAPFGEDYNCSDRLTFIPEHHFQYTYAHRHYFEHKVPPFGKLGCQELKEEEEKLPNNFESNSHEAAGNHRHSTFKSIANKIRFASQFLGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM56</accession>
    <name>A0A914YM56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM56"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20463.t1">
        <property type="protein sequence ID" value="PSU_v2.g20463.t1"/>
        <property type="gene ID" value="PSU_v2.g20463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20463.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18262" checksum="E8EF24A2AFC1A4E5" modified="2023-02-22" version="1">MDFWRFMTQCQKDSDESADFEDPDYIAVSLYYVDGPISAVDVFAHVDLSTTPKDSPPNSAVFPHLSLPPKKLRPIHSTRGRETEILHSDRQSLTTHIKERIGKIVRLSVILEMDANLFKTDRYLNAVSPTPVHSFLTANYRARVRSKVWRKKSKASMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN61</accession>
    <name>A0A914YN61_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YN61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2311.t1">
        <property type="protein sequence ID" value="PSU_v2.g2311.t1"/>
        <property type="gene ID" value="PSU_v2.g2311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038062">
        <property type="term" value="F:protein tyrosine kinase collagen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF634">
        <property type="entry name" value="DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="59"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2311.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40663" checksum="57786B29B1008CEB" modified="2023-02-22" version="1">MPQQICFKVNIHLLQQIFGKFFQKQNPTVYSSNRIDDFYSANLISTDEYAPIEICRESLESIKSIGSGEFGNIELCRLDNCLVAVKTLKATTATTTTPINNSEVEKDFLREINVMSQLKHQNVVRVVGASTKQSPILCITEYMENGDLKQFLTTKKDFVELTPEYLLSVTTQIAAGMAYLESRKFVHRDCAARNCLVDSNGIVKISDFGMARSLYASDYYRLDGHFALPIRWMAPESIFEGRFSHKTDAWSLAVTIWEIFYFCKEKPFSKLSDNQVIENLQESYENGTLKEYLQRPPICPPFIYTDLLLVCWRGKDSERPSLAAIHRLLQSAQCRLPTCLDSRPPPPKRAAPSPPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNV2</accession>
    <name>A0A914YNV2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">small monomeric GTPase</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YNV2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2531.t1">
        <property type="protein sequence ID" value="PSU_v2.g2531.t1"/>
        <property type="gene ID" value="PSU_v2.g2531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2531.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21235" checksum="0AAC91DEC6D96762" modified="2023-02-22" version="1">MTEYKLVVVGDGGVGKSALTIQLIQNQFVEEYDPTIEDSYRKQVLIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFALNELKSFENIQHYREQIRRVKDNDDVPMVLVGNKCDLTQRATDQRTIQELSRSYGIPYEETSAKTRVGVDDAFHALVREIRKHREKQKDKPKRKRRCDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNW2</accession>
    <name>A0A914YNW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19045.t1">
        <property type="protein sequence ID" value="PSU_v2.g19045.t1"/>
        <property type="gene ID" value="PSU_v2.g19045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19045.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24274" checksum="B1C57AF609A51449" modified="2023-02-22" version="1">MSDKDIVNDVKGSTFTAAVDFKYANNTVGGSAFQNAGIKKNTGKNSSLKDDSRDYSSPSSDEDDLINKHNQTVPSSCSESEEDTNEKDKDGEKSNENSSENDGDKNKISDDDDSMNGNAKNLKDVDSSDEELAELDNTILTDFDDNNPQKTSNKVGIIAENAHNLIGYGAAKKLFRLVAANPILFFGVIPMVFPEAGVIVAFLLQDVMKAYKLKKKRMLFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP53</accession>
    <name>A0A914YP53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YP53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19132.t1">
        <property type="protein sequence ID" value="PSU_v2.g19132.t1"/>
        <property type="gene ID" value="PSU_v2.g19132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19132.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26246" checksum="2A790DE4D94901EA" modified="2023-02-22" version="1">MKNHIRSKHPEVHAELWPVVKPEIKINKITTFLSTESMQQLKVDKEIIAMIARLNLPFTHVEDEYVRKLLVKEHGENYIRRETYYRITGLDNVHNSWLEVIRKELKDQELGISADIWGNPSLNISLLVITCQYISKNFERKHRILAVKAVKGKHTASCITNLFKSSFKVMELKKENIVYLTRDDGSNIKASATQQELNSTQCFPHCVHLIINDGKKGVEQFFKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQL3</accession>
    <name>A0A914YQL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQL3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3092.t1">
        <property type="protein sequence ID" value="PSU_v2.g3092.t1"/>
        <property type="gene ID" value="PSU_v2.g3092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3092.t1"/>
        </source>
    </evidence>
    <sequence length="439" mass="50067" checksum="38F4A3CC06592023" modified="2023-02-22" version="1">MFDHSTYYKYMPTFWTTVGDAYNKMQRKVINYMQEKEGDVHLAADGQFDTRGFSALMCCVTVMDAVSRLILNTVCLDKNVEKCPSTNLERLGLQRALQQLIDKSLIITTLTTDRSKSVIAMMQSSFSNITHMYDPWHLIKGVATILRKECKNARAKNFKEWCQALLNQLWYSVTSANGNGKLCQEYAVSALLHSIGIHEWEAGQMSKVLHDSQAIALAVDSDEAFYNDPLELPGKLIHENEFEGYLRCGHEFPFTETPSKAIICPLSKSYSILQKTFTNDNFLNDLLHLSPKLATSSLEGFHGLVSNIYRTKNHYFDLKGFNNRTKMAVLHYNNNIFDELNGTRTVVGTVELKAKHRGGDIVTKKRKTPPNFAWKKEIIAEVVSGYEAQLDILLKEGMFEGDFEEEIEEQIEDEIEDSYINVDDRIDGLFESDFEDDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR98</accession>
    <name>A0A914YR98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTH lysR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g329.t1">
        <property type="protein sequence ID" value="PSU_v2.g329.t1"/>
        <property type="gene ID" value="PSU_v2.g329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000001">
        <property type="entry name" value="LysR family transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="LysR_HTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30346:SF26">
        <property type="entry name" value="HYDROGEN PEROXIDE-INDUCIBLE GENES ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30346">
        <property type="entry name" value="TRANSCRIPTIONAL DUAL REGULATOR HCAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g329.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15045" checksum="262726149322832D" modified="2023-02-22" version="1">MTLTELKYIVAVARERHFGRAAEACFVSQPTLSVAIKKLEDELGVVIFERGGPEVAITPIGLRIVTQAQKVLEEGANLREIARQGHDPLAGPLRVGIIYTVAPYLLPKLVPKQIELTPXMPLLLQETFRASAGIAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSJ1</accession>
    <name>A0A914YSJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">26S proteasome regulatory subunit Rpn6 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20377.t1">
        <property type="protein sequence ID" value="PSU_v2.g20377.t1"/>
        <property type="gene ID" value="PSU_v2.g20377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit Rpn6 N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20377.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15535" checksum="1C62CF068F413A2C" modified="2023-02-22" version="1">MSTAAVISPVAASEVAELTKYVQKSLLEATEDIKKREDSLLKLGKLLSEAKELEQLKILIHDSRPFFSLVGAARAVMIIRNLIELCLKIAGGDGNIKVDTCNDMIGWAKNQGRVYLRQVLQARLVRLFNDLQRYTGMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSJ7</accession>
    <name>A0A914YSJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSJ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2985.t1">
        <property type="protein sequence ID" value="PSU_v2.g2985.t1"/>
        <property type="gene ID" value="PSU_v2.g2985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2985.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12565" checksum="CA646297F2171567" modified="2023-02-22" version="1">MEVEGRRCSRLFFGEDDDDQLCESDRGAADDIELMVGQLCESKNGCGVDPARGDLYFWNGDPIDARMYMVGMVDRGDRGIHESQASLASNDYGLNHEGQGNPASHDIFPRGYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVX9</accession>
    <name>A0A914YVX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2237.t1">
        <property type="protein sequence ID" value="PSU_v2.g2237.t1"/>
        <property type="gene ID" value="PSU_v2.g2237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2237.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21857" checksum="5BA2094E4048E996" modified="2023-02-22" version="1">MFNDYRYNSNNNSRLPTSASSIHIPSNYRSQNSLQTDSPVIQSASCSNIIQKTVGINHFEDSSLSKVAAAAGVKNTQAAPLPHSIFRRFRLVSEMEMENSSTPTSEAQQNYSKMHSSSISSITTATTEAAAAAGARIGDGGKSDWYNRGRLEHSQSHGAISHLQQPLKLQVDEYNNNNNNNYGDDMLTDEDGKNCKFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW53</accession>
    <name>A0A914YW53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YW53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2304.t1">
        <property type="protein sequence ID" value="PSU_v2.g2304.t1"/>
        <property type="gene ID" value="PSU_v2.g2304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="4">
        <location>
            <begin position="127"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2304.t1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44745" checksum="4849E2AF4048B338" modified="2023-02-22" version="1">MPLSALLCKNVFVPCYDQVCTRRFHWDVRTPLGPFCEGTVNPTCKRGVEKCCICGACSTKILVTVLSSAVRYNVLICYYGEACFTIISVVNVMDMLWNIGSGGGKRKNDDDGSTEECNNDFFIPPRLNYLQRHVKILLHSEGRHLSIQDLFLQGDHVNGLLTGVAAFVARMKIRKVAVLPAFVSEMLASNPNVDLLRYLQVYRSNFDILLAPVCEVSHWFLVVFYVDTKIVTSYDSMKSGPPLIFNALKRCVESVLHVQFAYEDKSDMVTLQQNGYDCGVNGFRMGEQICFNGENSLIEPFYAEAERARCREILRRLTVNEISDEWVPPVLNATDFVDLNKPFDTEAITVNDSVNDSEIEIIKIDKADDKNNDTVIKKQNEIEEKIKMLNHNHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWQ0</accession>
    <name>A0A914YWQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWQ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4079.t1">
        <property type="protein sequence ID" value="PSU_v2.g4079.t1"/>
        <property type="gene ID" value="PSU_v2.g4079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4079.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="56266" checksum="C652A695BAE144ED" modified="2023-02-22" version="1">MEVDERPQNASRSFSGTTEDKMDSPVGKPTTTTSLSPEKSLFGNSADKLRESNLESIVSNGNTSSNGKETFEETNGKEDPEEMEVDISKDEDNKDESLENKLLLVDDKKIDDKPVKGDKNFIKAGGNKKDEEIEDKANEEICIRREVTPLTDNKVAKVPEESAAAEEEATTKESSPPEDVEMDTKDNEEEDADETPATEDIPEPEAPSTRRSSRRSNATPAKPLTPKATPKNAKKGKATPVVDDKAKDETENDEEKEAEMEEVEETKKDESETPSTRRSLRTPKSAVKEAKTPASSKTKKSEVAPKEETPATDDATSEEPTSSNRRRSTRAVVVKKEAEAKTTPAKTIKKEAGETTKSSAKNTRKRGAPKDKTDDDEKAEEEAEEVSETETKTPAKRAKKEDVSKETKSTPRRASTRAKTAASTPATVKTPSIKTPKGKATTPKEGKQESEAEDVEMESEDEEEGGEGEENEEEEEKNPAKGQKTPKRAPPKRGSATGKRVTKSRKRNVSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWT5</accession>
    <name>A0A914YWT5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Midasin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWT5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5002.t1">
        <property type="protein sequence ID" value="PSU_v2.g5002.t1"/>
        <property type="gene ID" value="PSU_v2.g5002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="67"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="377"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="746"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5002.t1"/>
        </source>
    </evidence>
    <sequence length="1164" mass="129815" checksum="DF291236D23B055D" modified="2023-02-22" version="1">MQFKASQQLLNPNETYASDMGHNKRKRKPFKPSEEGSSKRIKENEETQFLNELHQDATILLADLLTDRKLVFVEGTVGCGKTTLVKRVAEELDLPIVTLQLSDQIDAKTFIGSYQCTEVPGEFVWEPSVFSKAVTKRCLILLDDIDSATTELVSTLFLMNKSWCAPLHSDGSMTSFHPDARIVATVRSENNHSDSSELIRSFPMTVNLKPLSNEELRKIIEHKFPSLISVAEKLLNIFFELSQMMLTDSIIDRDLNANDLIRACRRLTSLPNLKDNQQIFIELSDIYVLSVSNISKRARLAAALGKHLSIPEQQVDTLLCKREPDVVSNTNGAKFGRAKIPVRKGILVDTLSSKHFGFTADAKRLMERIAVCIQQGGKEAILLTGETGVGKTSVVQMMALYSNNILDVVNLSQDSDSTDLIGGYKPIGTLELLTPLIENVEQLLKASFDTVKNSKFVSHFTTLLNEERFSEYLMLTEGTAKKAIENKCGDQLAWADVLVRCQRLSKSLNSRKSALPFAYVEGIVSKAAKNGHWLLVDEINLASSECLDAIIHVFDGNLETHPDFRLFACMNPATDTGKKKLPVGVRTRFTEFFVDEPTDRDQLTVIVRNYLPTIEALHLGRLLNFYKEICAFSPRKYSLRNLCRALSFSGDNLYGNPYRSLFEGVSMSFGSDLDNDGMIKFDRILLKHFENVPTGFARAPTDGKKILVEGSYIEKGDNSPTTDPHYVYTESIKKNLSRLSRAVASGRFPILLEGETSAGKTSMILDLALVTGNTVHRINNHEHTDIQEYIGCYAPDENGKLTFVEGVLLQAVRLGHWVILDELNLAPVEVLEALNRLLDDNRELFVAERNLVVKAHPRFRLFATQNPVGTYAGRKRLSRAFLNRFVVLRFDHPPFGELTQIVCARCGIANSPAVAMIKVLTELKRCRSNTGLFNASDGLMTLRDLFRWANRLAKSESGDWRQVLADQGYFLLAARCRNSNDASEVVRVLEQVLKVKIDTEKLFSIDSPYLPDLIGKQLAENIGHIVSTFGMRRMLVLSAEAWRCKEPILMVGETGCGKTTAAQLLSEGKLLSINCHERTETSDLLGTIRPKADGSFFWQDGIVVQAMKNGSKLLIDEISLASDSVLERLNPLLESSRTVLLTDAGADAEVVVAHSDFQVVATMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWV3</accession>
    <name>A0A914YWV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5019.t1">
        <property type="protein sequence ID" value="PSU_v2.g5019.t1"/>
        <property type="gene ID" value="PSU_v2.g5019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5019.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12012" checksum="8B2043D34784B945" modified="2023-02-22" version="1">MLLNDWKSIEMNKLSFKLWITGTLRVLPENVSNDYVASSIISKIYQCDVKRLALRDQVISLNELSFLCSSVKDLELYCVTVKNDDGTVVAFEKLVEQLPNAKEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXL1</accession>
    <name>A0A914YXL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4840.t1">
        <property type="protein sequence ID" value="PSU_v2.g4840.t1"/>
        <property type="gene ID" value="PSU_v2.g4840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="288"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4840.t1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43813" checksum="8D32782E5649AAE9" modified="2023-02-22" version="1">MGRRHRRSKVTRVVNLVKRIIAFFFSHVGLCALVIGYALGGAIIFRAVESPHEREIQSEVTRARHEVVNVAWNTTFTVNKLDRAQWERTVYTQIKKFQKKCMWAIRRGYDGKEFGVSAQWTFTGSFLYSLTVITTIGYGNTAAKTYFGKTLTIVFAIIGIPLMLLFLTNIGDVMAKIFRFLYARSIRLKYKLILWHKKRRAAKIRRANSLVAKLTRASTNRSYIGSGRLGPGVRDDCSLESLGVPAAAASDVHELLAARVHLDQLEVKESVEAQLQRISVPLSLVLLTLLAYLVAGSILFCLWEGWTFLDSFYFCYISLTTIGFGDKFPGASVGNDKEAQEKLVITSVYLLFGMALLAMCFNLAQEEVVNKVAWIANKFRSKEDDEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXQ8</accession>
    <name>A0A914YXQ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5291.t1">
        <property type="protein sequence ID" value="PSU_v2.g5291.t1"/>
        <property type="gene ID" value="PSU_v2.g5291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5291.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32071" checksum="46C043B16E2DCE77" modified="2023-02-22" version="1">MNTTLTDWENPLDDNKNNNNPSVSLSLQQIANSTSQILGCLMTNPAFQNKSDSVIKQQRPKPYEAASTSKSRRNELQVQNKPTGIILEYTDLMVLNEAVSKLNEVVTRLNEAYEIQTSTTSQPDDLFIPTSSPTPTINDEEDGIQILEGTITTSAATAADISNHLNDFFQDNNAETQLDPLLNVTNGLSSCLKPCLIVLKDDEHVYEYTIQKKRIGNEYYCCSSCRKLPSPRSNLVIYGDGKITCSLHNIECMPISKEESLRRQEKRQIRFAKSCNNNITNNNVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYZ6</accession>
    <name>A0A914YYZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYZ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5331.t1">
        <property type="protein sequence ID" value="PSU_v2.g5331.t1"/>
        <property type="gene ID" value="PSU_v2.g5331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5331.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19746" checksum="D3006BD3E139EF45" modified="2023-02-22" version="1">MGLDLICHEPQLENAIKNLLSFLGKFVTVLQTAFHPDGPKCYKKNNYPQKNSFFRAEIPKLIILTIPYIDNHPTASTYKQKIIAMNDALRNYVKKNKAKLFKDHNFIIEIYDWEKESKNYRQCNRNDMESRFKILTTALSEKYQMFIVEQERPKNSQENDFQDSAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ36</accession>
    <name>A0A914YZ36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5210.t1">
        <property type="protein sequence ID" value="PSU_v2.g5210.t1"/>
        <property type="gene ID" value="PSU_v2.g5210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5210.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13803" checksum="1FD597A4E4E16FD0" modified="2023-02-22" version="1">MENLDPEVFQIVREHMRTGKQITNEKWQNRLDEITAAYKILQAELNQPNDLPHKIDVDESIPEWEIRVIACNESVNKSLHPKVHLNVGEHRVELNAEKLSDLRYSIAQLLHRMQHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0B8</accession>
    <name>A0A914Z0B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0B8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5615.t1">
        <property type="protein sequence ID" value="PSU_v2.g5615.t1"/>
        <property type="gene ID" value="PSU_v2.g5615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5615.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7895" checksum="AD62FFEDA4E38160" modified="2023-02-22" version="1">MLEHDSEVSVPGKINFDDDEGNTSILTNAQQKHKRSKPVQQYLGVELQKKLVEIKKAWEEERIRSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0S8</accession>
    <name>A0A914Z0S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0S8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5960.t1">
        <property type="protein sequence ID" value="PSU_v2.g5960.t1"/>
        <property type="gene ID" value="PSU_v2.g5960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5960.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31806" checksum="6705848C1FF1AC6E" modified="2023-02-22" version="1">MEYYFRYLKGCCFENYEYIVICCSDQLLKLKNEIQRLCSNILFPNTEIYIIGSRAPLFTFWFSQLKRKPNFGELFAVSRIKYADPKKSGMICGLFTRYKIEDQEFLAQIDGINTEKNNFRDLENKIEENMPIYSPTNLNVKIIYVAVYPDGYIFEDTSNLVFKHFSHKDTDRAKGALIFAKNKVNGIFGDYIEIEEKQKSEVKVMKELSIPTSTSWRSSSKSSNIQNVVEKVYQQNYQKGHEKNVVGIDIGTTTCRAVAIIDNENINEKCGIGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z132</accession>
    <name>A0A914Z132_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g5832.t1">
        <property type="protein sequence ID" value="PSU_v2.g5832.t1"/>
        <property type="gene ID" value="PSU_v2.g5832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="1"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="132"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="607"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1143"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="1501"/>
            <end position="1773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5832.t1"/>
        </source>
    </evidence>
    <sequence length="1915" mass="215394" checksum="3E289EEFFFA9246B" modified="2023-02-22" version="1">MQWFKEDRIIKFICVTTDQEIQSKAEYLKMADNIVISPAGANTNNYANVDEIVEQAVRCGADAVWAGWGHASENPRLPEELSRHNIAFIGPPSNAMFALGDKIASTIIAQTVDIPTIEWSGSGITAPEPDPSSSVQEMNIPEEIYRKATVSTADEGLKCLKEKKISYPIMIKASEGGGGKGIRKCTSDQEFILNFRRVQAEVPGSPIFLMKCMENARHIEVQLIADLYGNVIPLFTRDCSIQRRCQKIIEEAPASIAPPEILHRMSQDAVNIAKKVGYVSAGTVEYMYLPDKEKYYFLELNPRLQVEHPCTEMIANVNIPAIQLQIAMGVPLHRIVEIRLFFGLERYGITELPENQIRTDTNICVIAARITSEDPAEGFRPASGAVEVLNFQSNQNVWGYFSVSSTGKVHEFADSQFGHLFAKGTTRHEAVSALMCALKELELRATFQSQVNYLVGLLRDPEFENNAFHTGWLDERIAAKIQNMPEHPLHVIIAVGATVIGYSRMSEVFSKFQNAICRGQILPTSELTETWELELVHNNIKYSVLVNRYGPQNFLICLNDNICHTTVRQFDTGGDLLVTYDQQSFQCYLDEEMDRFKVSIGQTMTIFEKENDPTILRSKNAGRLLNYLFKDGEKVAKGQFFAEMESMKMVIALEISKVGGTLNHVARPGQVLFPGTIIAKLEVESDVSASRPVEFEGGFEQWTKAEERRNKKIRINHRFEQLLKACEDILDGYTVSNHMFKECLAKYVDELFDVLDDPQLPFAMYSHVLASVKSRIGSPDTIKRIEELLKENVFNAAEISDTLENYLSNLNPKEIGIERGHFINLQKICENFSQGSEGHKRIVIQQLFEHFLRTESYFQGVSYEKGVAAMTYDVKDPEQAVRTVYCHTKIQFKNALLEALISKLTDSSIIALQSLLKVLANLDNPENEELAYTVRNVLKRINYSLQNGIIDKSFLQLERLPKGSEETHQSPYFLFKYEDQGIKRFFVRHVIKDIAEAIKVSKYSKQSPLEKVHNKLADVIDGACGEIRVAAHNLKTDKLCNDCNHIFICIDNTTYSSTVGWPKTIKDVLLQHEKMFKKLRITEVEVVYQSNDFGESEDFYVIFDNETGAIPDVGFYKSENGYFKTLGDGSAKYHGLSVNDPHLPIAHVKIQKRRMLAQRIGTTYCYDLPTIFGKAVLNIWNLFQKSHPNSFQKIQQFLNSRQRDSLRLQDSNGFCKTYEMVMESEQGPITVIKDEALLKKRAETVGNDCGMIAWEMEICTPECPQGRKIIVIANDITHQMGSFSMKEHRLYYFASEYSRKHKMPRVYISANSGARIGLASDVKEKLNVCWNDATRPEDGFNALCLDDSAADDNSILSQIEYTKRSDGKTVIDAVIGKEDDIGVENLVGSGLIAGETSAAYQEVPTYCLVTGRAVGIGAYAARLAHRIVQVEHSHIILTGAPALNSLLGKEIYTSNGQLGGTQIMYHNGVTHSVAVSDLQGINKIVRWMTYLPSEGPYFTDDGERLVSTSPSKAQYDPRDILDPTDGGGLFDAGSLDEIMDGWAKTIISARAKLCGQPVGVVAIEPRTISFDIPADPAAAESTTRTVTQAGQVWYPDSAYKTAEAINDFNREGLPLIFLANIRGFSGGQKDMFEMVLKFGACIVDALQSYLQPVIVYIPPYGELRGGAWAVLDTQINPTCITMLADKESRGGVLEPDGIVEIKFRQHQLHDLMMKCDDRLKELKGALDKALTEGDKKLLNQKIQSRKEFLMPVYRTIAVKFADLHDTTARMLAKDAIHDQLTWSQSRNYIHRLLQVHLARLDMARAYLQIQGIRDAITIKDLQKGCNWVDEHLSANNITYRQNTGQSKKDSRFKYDIRAIQSYAQSNEFKRVLEDIDVENSSLSLLKKLDSLSTEAQRKLAQSLLQHIKDKNLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1V7</accession>
    <name>A0A914Z1V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1V7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4237.t1">
        <property type="protein sequence ID" value="PSU_v2.g4237.t1"/>
        <property type="gene ID" value="PSU_v2.g4237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4237.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="24901" checksum="CA8A2C3E79AD9085" modified="2023-02-22" version="1">MKSFLQVKIWFQNRRSKQKKLCKGNGEPLSGDEDSLKDPDMSPPNSVATSIDGGGSNVSNTEENHRNSCNNNTEQNIIASSSTPVSLSSNLINPIPVSQSQQQQQQQQPPQQQPLQPSLMQASLLGVDSNGIDWSSHMNMLPGMANTLASTSLPPHPHMTMHMQQMQLSPHQLGAATTFTQNGGFVQQPGFWDKGSEADMKYYEHMAYYPHQPPPYLTYNPNTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1W9</accession>
    <name>A0A914Z1W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1W9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6699.t1">
        <property type="protein sequence ID" value="PSU_v2.g6699.t1"/>
        <property type="gene ID" value="PSU_v2.g6699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6699.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9004" checksum="CF74BD5151C970C0" modified="2023-02-22" version="1">MNKWLAEGHLYTDNSAALDTELLAAPEDPNELFFAQHAEMQHVNLGETEEEQNEIDEPKLAVFVDDIDEDNGIFPQEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2F7</accession>
    <name>A0A914Z2F7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2F7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6540.t1">
        <property type="protein sequence ID" value="PSU_v2.g6540.t1"/>
        <property type="gene ID" value="PSU_v2.g6540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF236">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6540.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="31277" checksum="DCC994245CAD7E6B" modified="2023-02-22" version="1">MVEWANIATGVTVTLSTSMILITTGIMLALYQDINSLYDEVMLDMNEFNTKTNDAWTEVMMMPLAPMAKTPSENIRNAFESIFRIKRNNYNNLPGHCNCGTQPNRCPPGPPGAPGRDGDDGEHGSQGPAGETGASGIALAQQIYPTPDPIICPAGQPGPPGSPGGPGEAGPPGPRGAPGPNDLPIGPPGPPGPPGDSGAEEGPDGIPGMPGLDGKPGIRAIPGSPGPKGAQGPPGDAGIVGEPGSSIDGEPGPPGEPGEAGLPGMPGPKGRDGEAGGEGIPGADAAYCPCPSRGSAIETFDAKEKYEKLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2R1</accession>
    <name>A0A914Z2R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase-activating protein 39</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2R1"/>
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        <property type="protein sequence ID" value="PSU_v2.g6171.t1"/>
        <property type="gene ID" value="PSU_v2.g6171"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000045">
        <property type="entry name" value="RhoGAP domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="4">
        <location>
            <begin position="342"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="505"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6171.t1"/>
        </source>
    </evidence>
    <sequence length="697" mass="78488" checksum="E58BE538F0076E3C" modified="2023-02-22" version="1">MSQTEPDPQWIEIIDPQSRQRMFANLVTGHCAWEVPTGVAVRRMEANQWWELYDSETRRSYYYNPMTTQTIWQRPVLGDIIPLARLQALKQNTERGGAHLPEPNRPSSSSSTPRNRRRAHIESTTSLNPRNNLTISRTTNASNDFAHIEPSSSLTSRNSRDNSIRTNNVHIEPSSSAFRNSHDISHTANASNEFYANFCNDIASQLPDYPSGSGVNDTSFSSDQKKTRAPSTCSSRSQVSTKSTSTKLQYNNCIQEMVTSQFAAPESSASSTPMMGRAINGSNFPRHFRDCSPTSSVSSCGQSTDILSQTMSTAFIPRDSSLNKPNQRQSAPPVPFDKSECWSKDGIKHALLDPHDKKLKKYASSVFKLIMSYMGDKKSKTVPEQTALSILELRQEKPIINDEIFLQIMKQLTENAKADSVRRGWELLGILLFFFTPENAEVKEKLSKFVDNNSDSLLDGPEVSISQYAKHCLKRLQAPINNLKPSINAITQARFHIFNPSKFGASLEELMEEQSHSNPDLKLPWIEITLIQLILENGGENTEGIFRIAADPEQLNTAMVQLDQNIKPRLKDCHVAAVLLKQWLRQLPTPLIPDLIYPKCLVVSTQAENACCIVDQLPAINRLVLAKLLQLLQLFCKEETVTITKMDVANLAMVFAPNILRCESDDPHVLMNNSRREMEFMKTLILHYDTTFVHSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z302</accession>
    <name>A0A914Z302_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosol aminopeptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z302"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7078.t1">
        <property type="protein sequence ID" value="PSU_v2.g7078.t1"/>
        <property type="gene ID" value="PSU_v2.g7078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10590">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF4">
        <property type="entry name" value="AMINOPEPTIDASE NPEPL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="104"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7078.t1"/>
        </source>
    </evidence>
    <sequence length="424" mass="45339" checksum="2750A48546E7834B" modified="2023-02-22" version="1">MSTISIKSGLSDGYSLPKSQVVIVGTKPYLKTLQFEKNLASKLNGINEDLFKAALILQEKSKSVPLYLNLAKIISLPAEASHGKKLEEKDIKFLQSLIENIRICAQQVDTPCNELHSEAFANEAIKMVESLGVPIQKTVIIGEKLKEEGFGGIYHVGKAAVNPPIFACFSYTPEGATENIALVGKGIVYDTGGMQIKPASGMVGMKSDMAGAAGLLGAFCTLVKNGFKQNLHCLLCIAENSISPVANKPDDIITMLSGKTVEIAHTDAEGRLVLADGVYYAKTKLNANVIIDMATLTGAQAFATGKLHAGILTNCEKWENKSLEAGRKSGDLVHPFVFAPDLHFKDFDSKVADMKNLHSESSVGAPSSTAGLFIGSHIDFGKDCSWLHFDIAFPASSGERATGFGVALISRLLGNYTDVDIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z336</accession>
    <name>A0A914Z336_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g6307.t1">
        <property type="protein sequence ID" value="PSU_v2.g6307.t1"/>
        <property type="gene ID" value="PSU_v2.g6307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1397"/>
            <end position="1410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6307.t1"/>
        </source>
    </evidence>
    <sequence length="1501" mass="175896" checksum="85EFF3B82B4B2361" modified="2023-02-22" version="1">MLQQPSPIKQPVPVQEKLSEMPKTPSLQLPSSSATPLSKSPGKSFPATKAINRRSAAVTRLRRIDPRKNLLMKPKAPPIMISGNEAKIATRLMQPIYYGELVVNKKPRKGFPPVRARLIGGKIVKPYTKLLSVMYTPKRQKPSRKALRRMANERSFTITREIERGERPPFNNAKMNLSEIQSSQPNLPNILLTPSTEASTSSKKVTKKPLNTSSKHRPLQSRTNYIRRQHLPFRRTFFPFSIKPQFYKEKEKAKPKELSEEEKKERMETIKILNNIPWRTLPKKSKSPMLPRIWHPPIQINKGWIVLPKTHSLCRPIPFWHPPLLWPPKTLIAKRKKLFKIDGKIDFFLHPSSNEGIIKDDDVMEVDNNNMQKRIHFAVPLMNIINETNQEIDLTKVVFDPNANPKKSIFAPKKFTDLPSLKEEKEAKARKKIKNKNSKNKSKSKSKKGVKNERRAKSPPLVKKIYQTPTFRVPSLRPPPPPTQEPSEPDIPIDLAKNSLNNQKKIVTRLDEQKCVDLLYEYRLAQVRQTQPKNMWEANNQKMIELMKTKGAGIDSAVREDAGKALKFLEEKASKLTGKHSEIRNRLLQFCVDYGYEYSYEENDNYFYLKIGDFTVQLELQDYLVKNAWFFWSNIEPIFAPHIAKMFCRECWAKIHQSIDRMRHIIPTSITSEEKDLVLRALCCMERDLVRYYEKVEFRSHIFALNDILVRTDIYPFSIILPRSPVEIIKNESKIHSALDKFEKVKNIATLQIQISPLERHKFCIQSSLTPLNHWASPDTYKVGARFVIKFAKPIPIRYGAIKQLESIIGDIISKENYVNVYKYISLKQHGREVLFNLSDYSKQFVMYFDFDQFDKETRNDTILNGFYIDKASQLISAMYIIKREYILNRLCESTCENNPDLIEWRYLSVKNKKIPIKIRLSDIYDGHLCLYFQYRCYLIEARIIIRPSGNVGLGRLKIVHHGNKLDTSYHTVSRYQTFIDEWHLTDSVYLKASQLSDLNGVLQNTWHIPAFVDQLIKFIKNRCADNNVKEIHAFKPVYSSDRNERKKKSAKTKDPKPLEIIHKKKQKPRKSCKKGDGIRKNGDNDDEDDPSKDSNNKKQRKENPSKNGKRRSSGKSKGQQQKKNNAATATTSTTTKNDGKKMNKNAAVKLKMKRKNGKIYKKQLKRYFRNSIKNVLKRYKKVHLKALLFKKNKMVTTTIKKMHMKSKKQFKQSNVYRRFKIRKQLHQKKNYNKSGDFRRDRKKRSLLKPRMLNKEKHGSAWNDFVSKVNDNNEEMYKAPQKILTWPMLADQRVIRRFSNTKIKGDPHMDEAGRIEELDEYFNVSDCEESEQVCSYSYIPRKIVPPLPQRFRNMPATIDNTIGRLKPQIRKYLGKFKLKQVEQKENEKKSPEKEKDAEEAEEKEKEDETEDSARIQWGENWKQEDFMEIYKAAKERPLKKRRKRRIKHLLRPTSFKFISIINRDKQKSQGIFPYKVLRHAAICLRDGPYRGEPRKFKEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z471</accession>
    <name>A0A914Z471_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g5054.t1">
        <property type="protein sequence ID" value="PSU_v2.g5054.t1"/>
        <property type="gene ID" value="PSU_v2.g5054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF12">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218072" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="228"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="358"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="452"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="559"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="668"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5054.t1"/>
        </source>
    </evidence>
    <sequence length="1472" mass="160031" checksum="0FA816B7DF48B68B" modified="2023-02-22" version="1">MILHYLFVVLFVTDPINARRDKRQTGSGRVGDACAFNTDCLAGMFCNAGLCSCLTTYIAAESYCYQKIEPGQPGCVYNEQCSSVWPEAFCDTSAGVGTCRCGDKKVERATRDGHVCLDVHDANENTLAITCPLPEGAGYTSALSDPSHPRQNDGPGPVLCNTESTVISQTMGSDEMGNGNSACLFPSDNSYLADLYDCVEFVSVMDLTSAGYSEKANGICCPNRAFTCVQPTATGPNPSEPRWWYNAVTGMCQQFLWDPFASAAGEHSPNNFRTVEHCESFCRDACARGSPEYDVRATFIEETPVTGCSQTATCGANYECKTIGSIQWCCPSVTSVCGIVGGRPLDPSIHSRGAIYHSGVQKQGTAPSTRFYYDTNSGKCSAFTYFGAGGNYNNFMSRIDCELYCSRLQCDRGNPLRIGEMTQNCQSNADCPSSHECKIDQGVCCPRMQTICTQPLRIGNCDRSVRRYWYSATTRECQSFEYTGCQGNDNNFETLIDCQTFCRNASPEPRCAQGQAYKDHTGTFVTCSTNRAKSTCPANYDCYFDGNMFGCCPTKAFSCSLPSSPGITCGPGISYKYYYNPQTLECETFEFLGCDGNSNNFASRTECEGYCGVGGCANGGSPLRDNNGGLISCSDKSDSSCPPTHECQGVTIGNARSNRCCPSRAYICGLPPQQGSSLCSGGLTVVTRYYFNIVTKKCSSFVYNGCDGNPNNFASLNQCNNFCHAAACNAGDVVYLNPNSHEPITCNDEMQHNCPRNFACQYDKLTDQNVCCGATDMGVCPELEKAYINAMDMTVRECLINEQHSCPNDYLCRFNPQKNRYFCCSSISKTKSYCPVGRAPYREPLTRQPSRCTMNTANSGCPDGYACQSELNGALQGYCCSVSDICPNREEYYLDDTTLMPRACTIGQFVACPNGYTCQASHDGVLGYCCKGVAYMGSSDGCPPGEIVYMERNEVVACDPFNPQNQGCPSSFTCQWSVRSQRYQCCGSEVLPPVTEGDGCPSKQVAFNDNATKKPKICTSASFSCPTGYFCQFSTVNKQFQCCGIISDCPAGQVAFISISGEPQMCNMNGGAPCPDGYSCVRGRNGKELCCTGKNHKVGIGQRCFDQEQCTGGSKCSDDGKCQCPSGWMQEGQECVRKRINTKCPEDHINVENICLPLVDIGGSCTTSLQCRGGGICQGHVCRCPKNMVNKNGKCTSKEDKRGRPMPPKDGSFEHKPLTTGKVTTNDVCPHPLRQYLSNGVPKSCLSGKPCPIGYRCTFSKKAKGYFCCSNSPIFGQMKSTNAAAQGCPSGTALLFPRTSHPVVCSPHNKCPTGYQCLRSSVGKHYQCCTVSLIQSTSTTLTPVVAKPHFHNSKTSISMSTFRMLQKWNQFGRRGGLPTSITEGIHAIAQASPTWESYEKVKKPKTRYIEDENSAAELDVVPKHHALTKSLPCPSYMVLVETKINNKPVRRCQTSCPSSMTPIGGICRSVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5F0</accession>
    <name>A0A914Z5F0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z5F0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7576.t1">
        <property type="protein sequence ID" value="PSU_v2.g7576.t1"/>
        <property type="gene ID" value="PSU_v2.g7576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7576.t1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34023" checksum="9233660D14D175C3" modified="2023-02-22" version="1">MYGKDSVILSDICKRPAGFEHLTPFCYVNILDKTSIEEAVVNNNIDTLIHFSALLSAVGENNVPLAISVNGRGVENVLEISKSHNLKLFIPSTIGAFGPTTTRDGTPDLTIQRPRTIYGVTKVYAELLGEYYHEKYGVDFRSLRFPGIISTVEPGGGTTDYAIKIYYDALLHGKHICYLKPDTELPMMYDTDCMTSVIQMLHTPSEKLSLRTYNVTGFSFTPEQIAESIRKRIPNFQIEYNICPIRQKIADSWPRSLDDSTARRDWAWKPEYDLEATTEIMLELLTAKLLPPSESEPKLATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5N6</accession>
    <name>A0A914Z5N6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5N6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7658.t1">
        <property type="protein sequence ID" value="PSU_v2.g7658.t1"/>
        <property type="gene ID" value="PSU_v2.g7658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="3">
        <location>
            <begin position="153"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7658.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25001" checksum="C9E014E8C05C6A3E" modified="2023-02-22" version="1">MDSNLSSISTWPRNQTPPRIAKPLDSNNANSNRAIFTATLANLKQYAKKHDSQKARELIQAIQNFLSVTDITDYNNAGAGDRYQSNTIREEPHFDSMILCDTERTAETRRIDSGETNISNVLNFPVTPSIEEESHEPVWIRAIPQILLTFLCISYLIIGAWIYQYYDPELAKLPFHTVLTLTFQICTTLGWGNFAPTDQASRFFTLPYAVIGIPLTFACTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z645</accession>
    <name>A0A914Z645_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z645"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5714.t1">
        <property type="protein sequence ID" value="PSU_v2.g5714.t1"/>
        <property type="gene ID" value="PSU_v2.g5714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339:SF6">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="322"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="426"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5714.t1"/>
        </source>
    </evidence>
    <sequence length="1217" mass="131515" checksum="EE5E1F35A93423C5" modified="2023-02-22" version="1">MYARTGTSYCCQNPTNFQQANSDITCNGNQVTFYEPLTGEPRICVLSSSGGSSSAASTACPVGFGCNLVGGTMTRCCGKDFGCPYNSAGFLNPHTGGHVQCTIGDEATCPEGFVCAQSTMFNGGVCCSETSSTINDACMGDTPLASPNPCSANNPCPNGYNCRNGRCCPSKGMCPVGQPLAGVTTCSAENPCPNNYQCITNDGQQFCCPAPEHVCHQPKDTGIICDMPQNSIVRYYFDEGTGSCRSFKYSQCGGNANNFDTLEQCEGFCVSSQCPQGRPYQSGASNAACSPLTPSTCPNGFTCMQPLFGSNHICCSSETLSCRESASAGTDCFGAALTILRYHYNSDTGRCESFQFYGCHGSSNNFFTRHECETTCQMNLKDICNGVSPLMNPSHQPQRCNPSMPCPAGNSCNLEGFCCPHSEYACRAAKNVGNTCTINRPGTFWFFDTMALECVPFTFSGCGGTPNRFTSKEACERICQNQMGECPKGMGIAEVFPGGGPQRCNLNLAATGNSGCRTSNADCVLSTSNTPICCISLAQCPVPSQAYIIPGSNSHVVCDPSDDTCPIGYECIRSATVAGFYMCCSSNPIYGNSINPRKAPVNRYLQAASPGKCPIGLDSNGQRCVVNAIGGCPRGYICLGAGSHGVCCRGLPKCTQPRHKPYYFSGKQVLICGEDQILCPDNTVCSESTIDGVDICCQTSSSTRYSHLSNSNLNVARCRDNHLPFFEIGHREPKMCDETSHINECPDDYECSRASDGQYYCCPSWEKCPKGASPFLVEGTRKPLGYGEEEMVQDCPNGAAYGNPYNHQKQICTPGMSTCPSGYICRKSLASHEHVCCTSESLNILERKFEGYCPPGQIPYMQPNTIEPSPCHMALSPCPTMAPYQCIYSAEKQNSYCCTLSGTANIPFTFHSRRQGIQMHPQQGGQQQQQQLQQMPPQNFPQKTMTISNNNLPSSSDNSQMFINGPNGEKIPKSMIPIQLLSAEKMLPAALPGAPVSGCPTQTQPLLNAESRQAHPCSTMSRCPDGFTCYSNFHDGRNAQCCTTMPSNEDDATFMRAMMPGKIREPIKVCPQGFIKLGSVCKRRIVQKSLFYVGQPGCSSDEQCQSMSNSTFCEKGYCRCPDRKLIHQSECVDSCPEGYVHIAGRCHDLTTIVFMDSVEDRANGTIGGYCGETVVAEEQCIVPNSYCNERSITCHCKPGFELQMNFEDKNDTVRNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z651</accession>
    <name>A0A914Z651_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z651"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7390.t1">
        <property type="protein sequence ID" value="PSU_v2.g7390.t1"/>
        <property type="gene ID" value="PSU_v2.g7390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000029">
        <property type="entry name" value="Kinesin-like protein KIF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="14"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7390.t1"/>
        </source>
    </evidence>
    <sequence length="683" mass="77336" checksum="3412B3EA9BF074AB" modified="2023-02-22" version="1">MNGSPEGLVGESDNVKVAVRCRPLSKQENEQGFTSAVAIDEYNSTVSVINPLNHEEPPKTYTFDEVFGFTSNQITVYNKVARPIVENVLEGFNGTIFAYGQTGTGKTYTMSGEMDESDKRGIIPNTFVHIFDHISKCQQDKTFLVRVSYLEIYNEEIRDLLAKNQKQSLQIKERPGLGVFVKDLTMSTVLNADHMYNIMQYGSANRHVGATNMNEMSSRSHALFTVTIECSYGIGNDASIRKGKLHLVDLAGSERQSKTGATGERLKEAAKINLSLSTLGNVISALVDAKTSHIPYRNSKLTRLLQDSLGGNSKTLMIANIGPATYNYDETISTLRYANRAKNIKNVARINEDPKDALLRQYKEEIEILKRKLENDEGGGVESEEDENTAAMTGSKHPSTHHNWDEKIREMEEDIQIKRDQLEKEKGLADAEKRQLAEEILLQEEELKKTKEEHQKLAEKLATIEKKLIVGGENMLEKAEKQAQLLEESNRELEKAKSSENELRKRLESRQAEHLNIEEKYNSLQEEAAGKSRKLKKVWNSYMQAKGELADLDGEHQREMEGLLDNVRQLQKELKLYGTLIDSYIPPEYMKMIERYVFWNEDIGDWQLKCIAYTGNNMRAAKHNPPLVYRSNESQIKAPYLSYADLLDSPAQAQQISAPSRSTFRPKSAKKDRNAARIKALLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7L7</accession>
    <name>A0A914Z7L7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7L7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6235.t1">
        <property type="protein sequence ID" value="PSU_v2.g6235.t1"/>
        <property type="gene ID" value="PSU_v2.g6235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6235.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17158" checksum="57DB5F01AB55B870" modified="2023-02-22" version="1">MTNIYQQHFLNLNNDFEARNDLKKSKSANNSTLSLHIAAYENFIEDNADSERDDDSKSKTEKIALIKKWNTSKQRYIRSLSFIKNPFEFPRQQEDRPNLPEVMQFKASQRLRNLNEENLNFDEKAATVSREQTNRLPTTAGMERNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7R4</accession>
    <name>A0A914Z7R4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="1">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.3.1.41" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z7R4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g629.t1">
        <property type="protein sequence ID" value="PSU_v2.g629.t1"/>
        <property type="gene ID" value="PSU_v2.g629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Beta-ketoacyl synthase-like N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g629.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10527" checksum="39629F631393DEF9" modified="2023-02-22" version="1">MKRRVVVTGLGIVSPLGNDLASSWEGITQGRSGIGPLTNVADAYLDRFTTKIAGEVKGFDITADNELFGKFRVSGKDAKRWDPFIPLRPRCLVHGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8V1</accession>
    <name>A0A914Z8V1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.179</ecNumber>
            <ecNumber evidence="3">1.3.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-xylose 1-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Dimeric dihydrodiol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16729"/>
            <dbReference type="ChEBI" id="CHEBI:10702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="4"/>
    <dbReference type="EC" id="1.3.1.20" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z8V1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8261.t1">
        <property type="protein sequence ID" value="PSU_v2.g8261.t1"/>
        <property type="gene ID" value="PSU_v2.g8261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047115">
        <property type="term" value="F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="12">
        <location>
            <begin position="161"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8261.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="38026" checksum="F33E42198C67EC55" modified="2023-02-22" version="1">MLEKLRWGIIGCGNVSGDFAKAINYTTYNHSISAVAARDLNKANEFVKINNLGDNVKAYGSYTELFKNETCDIVYIGVLNHCHKILVLEALENGKNVVCEKPMGLNYFETKEMIEKAKEKELFLMEGYWTCFFPAFKAFHENLKKIENLNLAISECGFANHAPNKLEKSLGGGDLMATGCYNIMAILSVFENENIKKIISNGCKNESGVDVWSSILIEFENDKIASIFNTSLATTPSSFFVSGNNGYVKIPEKLWCPTKILVNIDNNLEGFCFKLNKSKDGNERDFQYPRAQGFCYEQDHVFECLKKGFKESPTVSWEKSLKIAKLLEEIRQQLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCH5</accession>
    <name>A0A914ZCH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZCH5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9627.t1">
        <property type="protein sequence ID" value="PSU_v2.g9627.t1"/>
        <property type="gene ID" value="PSU_v2.g9627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9627.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24451" checksum="EB54BF2EDE4DEC0D" modified="2023-02-22" version="1">MLKKKAIKLNVVARKPVVVPKTIKKKTKISKKPDPQSLSPFIVIRNAPYGFFEEPCYNYFSQYGQVKRVRVMRNKKGGFSGKIYVGFKYAEVASVVVTVLNKSLMMGENVIKCRQLLNSEVPAAVRFGSQFGKRGLKKSTYVKKRIQKAHVKKYKENPQAVADFINKQLTKAKENGIDYSFDFSKKFTTALEEQKVRNAQNQEKIAKWLKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDK4</accession>
    <name>A0A914ZDK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HotDog ACOT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDK4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8347.t1">
        <property type="protein sequence ID" value="PSU_v2.g8347.t1"/>
        <property type="gene ID" value="PSU_v2.g8347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000008">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007970">
        <property type="entry name" value="PRK10694.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF5">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YCIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8347.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="10758" checksum="5CEFA481CDDF9AD9" modified="2023-02-22" version="1">MSTTHNVPQGDLVLRTLAMPADTNANGDILGGWLMSQMDIGGAILAKEIAHGRVVTVRVEGMTFLRPVAVGDVVCCYARCVQKGTTSVSINIEVWVKKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDS5</accession>
    <name>A0A914ZDS5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDS5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8423.t1">
        <property type="protein sequence ID" value="PSU_v2.g8423.t1"/>
        <property type="gene ID" value="PSU_v2.g8423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8423.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12465" checksum="9696EEC1855FD247" modified="2023-02-22" version="1">MAFASVIYYAESLPDIPTPDEEATKLQNSTSFSNATGKDDSIDFCVTADNQATTTPAILTTLPMTVLSTTQSFEITTTTAEELETTPSTSPSTTTTPTKGITTTTIPTTLQGSIFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFA5</accession>
    <name>A0A914ZFA5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZFA5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8960.t1">
        <property type="protein sequence ID" value="PSU_v2.g8960.t1"/>
        <property type="gene ID" value="PSU_v2.g8960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="87"/>
            <end position="362"/>
        </location>
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            <position position="94"/>
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        <location>
            <position position="96"/>
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        <ligand>
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        </ligand>
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        <ligand>
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        </ligand>
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        <location>
            <position position="216"/>
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        <ligand>
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        </ligand>
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        <location>
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        </ligand>
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        <location>
            <position position="359"/>
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        <ligand>
            <name>Zn(2+)</name>
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        <location>
            <position position="361"/>
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        <ligand>
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        <location>
            <begin position="8"/>
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        </location>
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        <location>
            <begin position="109"/>
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        </location>
    </feature>
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            <begin position="285"/>
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        </location>
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        <source>
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            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8960.t1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52632" checksum="CFCF7281941F9647" modified="2023-02-22" version="1">MCVKKNTCVNLQIEQPYVCDKIIEEFGNEIYFAIEHSYLEPHEFCGAFIKECGTYENPLNQPWPLIIPGNKPSVKPWPIVPDGKPKMRVLHLADIHVDREYAIGSESLCSNDEGLVYAFCCRDYPPESNVGKADIKFPAPKWGIAENCDIPFITFDESMRLISLQEKFDYIIVTGDLESHAIWDYTKETTAANIANITATLLKYFPGIPVYQAVGNHEGVPMDAFAPHSIPEYEIRGPQWLYTVLNDNWGHWIPESVKESLQYRGSYSFHPFDGLKLISLNTVYCSHWNFYLFINASDPDMTLDWLAKELLDSEQKGEKVHIISHIPSGDSYCLKSFSANYYSLINRFENTIAAQFFGHTHNDHFYMYFDDANPKNRATHTAFVAPSLTTYSYLNPAYRVYTIDGNYPGSSFTVIDEENYWANLTEVNANDKLEFKLEYNKRVSRLALPHFIPEQRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZH82</accession>
    <name>A0A914ZH82_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9640.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29604" checksum="687211BF4ADFC9DD" modified="2023-02-22" version="1">MSNKTFQKRPVLTAASSIASSSSGQSRLSSPDSPQDRRAVAAAFLNAQKIDGLSESAALRRKSQFITSKSLDEQNNEKNAPKFQEFLKVSSPNRPSTPLHNKSLELQRACSIPAIIVGEIPKLIITGEICTPKQSQKNNQIESEKGQNGYQQCNDDTTHFTKNHREINNSNEFILDLHQRLCVFYLDITNVLSCHEASWHQNVVQPNAPPILLLYSLVEANGEMVVFGGMKDPTEANPFLHVNSLNESDYATNRTYLLKPNYFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZH85</accession>
    <name>A0A914ZH85_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Panagrolaimidae</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
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        <property type="gene ID" value="PSU_v2.g9645"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F59C6.8"/>
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    </dbReference>
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    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9645.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28781" checksum="19CA0D084139AFFF" modified="2023-02-22" version="1">MKSVSVNVPIRKAYENKHDVISCFSPLFYNERWQLIIPTLEIYRQYGVNLQVFYIQSIRKEIYNFLKVYKNANLIEIEPWISINLGSEHQKLKDPNSELEWRNQAGAHTDCFLKYREAAEFIIVADIDDILFPRIGKNYIQEFRSLALQYPFAAGFTYNRYNTEVVASKSPMDFSLYKLIDSARIANEWEDGKSVIRPSRVQTAWIHWPSIYESGYHIVTVPEKRNFMVHLRNWTMVKSLYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT79</accession>
    <name>A0A914XT79_9BILA</name>
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        <submittedName>
            <fullName evidence="6">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT79"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1117.t1">
        <property type="protein sequence ID" value="PSU_v2.g1117.t1"/>
        <property type="gene ID" value="PSU_v2.g1117"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="231"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="506"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1117.t1"/>
        </source>
    </evidence>
    <sequence length="740" mass="83454" checksum="1B4EBE37A92383F9" modified="2023-02-22" version="1">MVLTEEQRQRIAANKAEALRRQMNVRAANLANAQPQPRPQVPFPRPSTNSLPRPSTSYANPRPSTFPVRPPARPPYSGNRFGFPRPGQPFNRPPIPGYYAKNSFSKAPSSFNESKKKSFNVVSLSVYNSERFRLDMKVILDVVLQFAKGIPDRNYDGTKKCWHFPWNRYEEVRAGLRAIKEVDFEMEVLLPCVVEFFRNKKPLEKPDADNLANLKVTMWSTLYDYQRDGILRGIANNGRILIADEMGLGKSVQALGLAFYYRTEWPLLIVSPSSVKGSWDQQIERFLPNMCEVTMIEKTSDILPTSRSTKTVVIISHSMMVLKKDALLKSGFYVVIFDESHMLKDEKAKRTKAAMSLARSANRVILLSGTPAISRPAELFTQIQMIDPKLFPKFHDFAVTYCDGKETAHGFIAKGAARTDELTTILQEAVMIRRTKDNIVLPSKTRHIIYLSEKNIDSQLKELRDAKEQATKATSDRRIKKKDAHESMMEYYRVTALVKSSAVSTYLKNEYFKNNDCKRKMLIFGHHQVVLDAISSMLVSSDVCHIRIDGSTKDRTNLVEEFQTNEACKVAVLSMTAAGVGITLTAASLVIFAELHWTPSAEDRAHRVGQTRPVDIHYLIARNTVDEDMLNLIKQKMKILTSVSLNTGSLDNAKKSYEEPGVSKITTFFQALAEKENVNSDDGNKKKGNAFGAGEVITLEEDEDDWNDDEIFIEEESSSGAKKRPSVGDGDEDIPSKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU64</accession>
    <name>A0A914XU64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XU64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11496.t1">
        <property type="protein sequence ID" value="PSU_v2.g11496.t1"/>
        <property type="gene ID" value="PSU_v2.g11496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019825">
        <property type="entry name" value="Lectin_legB_Mn/Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00307">
        <property type="entry name" value="LECTIN_LEGUME_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="632"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11496.t1"/>
        </source>
    </evidence>
    <sequence length="722" mass="83540" checksum="286D96793ACC4DB9" modified="2023-02-22" version="1">MCIATFNHLALNPYIKLSLGLSSLLSYLTEGMDEKFVKQVHLDLRQILNGHYNIFMASEDDDEEVINHDGYLVYKGRLGKMKSLEIIKMVQSGELIEGEKVSDIFARLIYAENKLEAAAICLKCRKVFAKFTTSRNTFYTHSAYHTRSDDPDFVIPVFIKELMTESLAEMCATDMVPFYTVEKPGFRQVLQTMFTLSYNLGLQQSKNEIIPTQLPDNIIDEILPCSNTVKNRVIEQVKYLTPTFSEHVKRHIVNFGGAVSIDFTTKGSNYFVVTVHYLSEIWELEHWQLELVEYKEDDSSGASVLESFLATMNNHGIDRETVKKNVIITTDRGSNMINAFKNNFVRLDDNCHQASIGSKRVTEPYKNGFLTDDYNLPQDKRETVAIVSKLLKDTTRIIKSVNARTRLKLKLQDDGIFLSKHCEVRWLSRYKSINSFTKLNEIQREKIFKSLWDEKANGRYLFREAIKNIRENYIMLVDYCAVIEPFNHFIKVLEAETYCTVNRTLIEYHKLEIHFRSCLTRQNASVEMKAMAESGLLVLQYQKTVPTTVSDYHFLGLLLDPLRKDEMANFTDMTEEELRKMKKLFIDYVRKYNEVAQNPSQISASPFRAITNPSNDIITVEIDSFLNLDSSVMRCEYEDVLDFWRKCSSNYPHIAKLARRVLPITSSCPAERSFSDLGNTLTPQRLLMAPETVTSLLNLKNLKKFEKEEEERKKKNCFECMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVJ0</accession>
    <name>A0A914XVJ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914XVJ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10990.t1">
        <property type="protein sequence ID" value="PSU_v2.g10990.t1"/>
        <property type="gene ID" value="PSU_v2.g10990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF10">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="94"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10990.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35417" checksum="2A21C1E71C0F9037" modified="2023-02-22" version="1">MNYKFNEIKAIVAAAKKVFESESTLLEVRAPMIICGDIHGQFNDLINMFLLLGRPPTERYLFLGDYVDRGAMSLECIILLMCYKIQYPNSIYLLRGNHECARVCLRYGFGDEITNFFNHDQATFLWELFQRAFNQLPIAGLIDGKILCMHGGVSPVMETLDDIKAQKKPLKNPFRGIVNDMLWADPDTSISFWRTSARGSGFVFGDKVISETCRRCNIDLIVRAHQLVVDGFWVFADRQLMTIFSAPAYCNIYKNCGAALKVDSNLHCQLVAFVPNGPKVKEMIVERNHLWETIETAKNASAESEKPLPRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWD7</accession>
    <name>A0A914XWD7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10845.t1">
        <property type="protein sequence ID" value="PSU_v2.g10845.t1"/>
        <property type="gene ID" value="PSU_v2.g10845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10845.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13325" checksum="11E63826A37D0B90" modified="2023-02-22" version="1">MAAPFKSDKPADEAEHRIRITLTSQNVRSLEKVCEQLIRGAKEEHLEVKGPIRMPTKTLRITTRKTPCGEGSKTWDRYQMRIHKRLINMNSPSDVLKKITSISIEPGVDVEVTIADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWG1</accession>
    <name>A0A914XWG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWG1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12276.t1">
        <property type="protein sequence ID" value="PSU_v2.g12276.t1"/>
        <property type="gene ID" value="PSU_v2.g12276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF28">
        <property type="entry name" value="D-ASPARTATE OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12276.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38527" checksum="D876A40504BB21A1" modified="2023-02-22" version="1">MALNIAIIGQGVSGSSTALSILEIHPSMKITLFADRPFEDTCSFGPAGHFEVMEAEHKKWGLISFERFAKLEREYGSKIGVKYVSGFVQSDNATFMEKMEDFNADIVHNYRKMSSREMKHIFTEPLKYGIHYSTYSTQGRLYVPWLKSECEKYGAKFIRREIHCIEELADEGFDIVINCAGLHGGKVAKDDNEMSPLRGIAFEIDAPGFKHFSFSELETFVIPLDNTVLAGTVRQPGRFDRTITEEDRREVLHRIYKLHPTLKSHKILQEWCGLRPCRDSVRLERQSRQSIKGKPFEVLHNYGHGSNGFTLSWGCAQEVLGLLNQILFESHIDTPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX14</accession>
    <name>A0A914XX14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial mRNA-processing protein COX24 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10294.t1">
        <property type="protein sequence ID" value="PSU_v2.g10294.t1"/>
        <property type="gene ID" value="PSU_v2.g10294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10294.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29812" checksum="F1F9E24083FCFD47" modified="2023-02-22" version="1">MQSSTSKLGNIRHFSTTLKSLRSLVGVSHQECALPIAAVSPQKLFRSVNLNVPPMYCPTAQRPVKVYSFPTPDKAIIEAPTILSLLIEKVEPLIPIAPIMDPNQSNKLPMIAGVRMLTIRRKKMKKHKRRKRFNRDWFKYQKYHRQKKMKAEKVFRARMNDLMKSLEKFDPMEHVTDTIKKAKREWSTDLTPSGKKKYPHWADLMTIEELYNIEKNDYIDKRAGLPNEEDAQQIAQLRQKYELQYSRKTKVDGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX68</accession>
    <name>A0A914XX68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11126.t1">
        <property type="protein sequence ID" value="PSU_v2.g11126.t1"/>
        <property type="gene ID" value="PSU_v2.g11126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44115:SF2">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44115">
        <property type="entry name" value="PROTEIN CBG09704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11126.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="12859" checksum="9B0FD1363762EFB0" modified="2023-02-22" version="1">MAHDFNGKVVIITGSSSGIGQAAAILFAKLGASVTIHGRSENGLKKTEDLIFEAGISKERIHSVRGAVTDSEVQKGLIDETIKTFGRIDILINNAGGVKDDETNQRSMAALDYCLDVNLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXT7</accession>
    <name>A0A914XXT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXT7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10547.t1">
        <property type="protein sequence ID" value="PSU_v2.g10547.t1"/>
        <property type="gene ID" value="PSU_v2.g10547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10547.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20228" checksum="3747F74CDD80A966" modified="2023-02-22" version="1">MIVVTNIPEQIDAPNEDELDKAAINNLIKNIDPGVEIDSLARMGRKTNGKKRSIKVKLQSNQQKKAVLSKAPTYIKSNPELLKNNTFINSMRSPESHRMQVKLQRRLNELRNNAKESKMDVRLYIQRNQIHLNDISNPEKNGILNDAVNEEVAAFYKQQNIFRGRTQSTTSDFEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY60</accession>
    <name>A0A914XY60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12141.t1">
        <property type="protein sequence ID" value="PSU_v2.g12141.t1"/>
        <property type="gene ID" value="PSU_v2.g12141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037893152" evidence="1">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12141.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18688" checksum="77D497E0301F0164" modified="2023-02-22" version="1">MELHIIALTVCSLFALGFGFAENDNFAFTDKVGQGNFAFAKLFAFADDGSMYRLTKRSLQEPKSNFAFNSNGIRNKFAKHRSSQPNEFAFAFAKRSAPFAKRFALMDDASTEWEEVDSTKPEFAKFAKRAADSDEASFAKFAKFAKFAKRSSDKFAFEQQPQTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY96</accession>
    <name>A0A914XY96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11506.t1">
        <property type="protein sequence ID" value="PSU_v2.g11506.t1"/>
        <property type="gene ID" value="PSU_v2.g11506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11506.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28443" checksum="04C7C123430A3E73" modified="2023-02-22" version="1">MFFYSPHPKPNIRRPTLGPQQLQVGQLDSRITAQIAEVLARSPPFHPESTRRSDGRRRSRPISDEISDEQIFAAAVHRASLAGLAVDGTEAILVPPPPPPPNIPQQIAIGRANNNLIFNNNLPGIPSQSSSHKPPPHIYYADVTSPQDSLFSLTESRRQSRANIHPRALILRRPTISIHEDGRILIDHVTARWDGVPLTSQSGLLDADEGGTIITDTLKEEERKEPKNCKQQTFKEFFLCYFFPSVFPSVILEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y021</accession>
    <name>A0A914Y021_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y021"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12565.t1">
        <property type="protein sequence ID" value="PSU_v2.g12565.t1"/>
        <property type="gene ID" value="PSU_v2.g12565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12565.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10589" checksum="31578BA93BDEB802" modified="2023-02-22" version="1">MYNKAARWADAYKLAVEFLGVDQTHEMYLQKAEELEQSGRFKEAEQLYISFGEPAKAIAMYKEANRMDEMMKLVEKYHGDRVEVISLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1F3</accession>
    <name>A0A914Y1F3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7515 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1F3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12617.t1">
        <property type="protein sequence ID" value="PSU_v2.g12617.t1"/>
        <property type="gene ID" value="PSU_v2.g12617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055937">
        <property type="entry name" value="DUF7515"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24359">
        <property type="entry name" value="DUF7515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7515" evidence="2">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12617.t1"/>
        </source>
    </evidence>
    <sequence length="379" mass="41553" checksum="0A6ED27B2E56DB02" modified="2023-02-22" version="1">MRHSAKKNVNPAPEAEIPEWNKLQSQINIVIGSVRDNAITIAQLKKDILDTFAYDLNRAAQTYEYTSIEEMLSDMVGYVHVRHTPGGVIVSAAVVGSSAHVTEMIQKTKGKTRKKTNRATTLMRSGYRPHSHLPQPSRGRGQRRRGAAPFRTTHTVPSFGSSLPQSSVRPSSSRCYFGNQPSSSHVYRPAPVYESPFFDSPPLRTNVPSFGGPPQPPLSTQDSSAKLRPSVPSLRSAPSQSSSVRFATSASARLPSSQNFSFRPLLHKSFSSLSTQGSSINLRHSVPSFGPPPSQPLLSTQDSSVNLWRHLLLGSKRPSSNRPVPPPRSAVPSHSTFIPEKTEDPLKPRILSPSEALLWKKKTFADYATKVSFKSAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2G2</accession>
    <name>A0A914Y2G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2G2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12971.t1">
        <property type="protein sequence ID" value="PSU_v2.g12971.t1"/>
        <property type="gene ID" value="PSU_v2.g12971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31873:SF6">
        <property type="entry name" value="ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31873">
        <property type="entry name" value="L-ASPARTATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12971.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22330" checksum="C6F1D1486FAC4786" modified="2023-02-22" version="1">MPSLHKRDEMIEKAKTSGFKLKESIDLGEETGFPFYYCFTSSPLFMWMVESPIISTLIKIGQAIKILPSGFHRFNDTFLAGTVAKIVKGGQMGILSGAEILKAMNTRKIGIIGYGHLGEFLSVELKNRQEFDVVKIWNRTPIENENVLPLEDITDETLKDLDLVIEVAHPQIVQDYAELILNHTNFFYWFTYCSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2G8</accession>
    <name>A0A914Y2G8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">guanylate cyclase</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y2G8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14370.t1">
        <property type="protein sequence ID" value="PSU_v2.g14370.t1"/>
        <property type="gene ID" value="PSU_v2.g14370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme NO-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Haem NO binding associated" evidence="5">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14370.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20498" checksum="F0DFA3BA159DEC5E" modified="2023-02-22" version="1">MYGAFLIEYTMEIGWDELLRTMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCEEGDDNSIILHYFTGRPGLYPIVKGVVREVARRVFNMDINITIAGRTQRSVQMSTGERIEEHVIFNIKMGQSKQDGSSIIPPPLSPSDLDSGVLRVNQEDFCLAFPYHIIVDRECKVVQVGKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4M8</accession>
    <name>A0A914Y4M8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4M8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14396.t1">
        <property type="protein sequence ID" value="PSU_v2.g14396.t1"/>
        <property type="gene ID" value="PSU_v2.g14396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14396.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="40763" checksum="CEB31EB4169CD38A" modified="2023-02-22" version="1">MNELQYPFFTGILYHTGSPALSILLWLLCGLYALLGALCYAELGTTIPKSGGDYIYIYEAFGSLPAFIFLWIALVIVNPTSLAVIALTFAQYCLKPFFPNSEVPDESARLLAAWCILALTFINCYNVRLSTRIQDILALSKIFALGMIVFAAIIYLAQGHLEHVTIEKLTENSNTGPIGIALAFYSGIFSYSGFNYLNFITEEIKEPNKNLPKAIYISLPIVTLVYILVNMGYFCALSTSEILNSDAVAVTFAHRAMGPFAFLVPIFVAFACIGSLNGIIFTCSRMFFAGARNGHLPELMAMINIHNYTPMPSLIFLGSTSLIMLFIKDIYILINYLAFSECAIVTMAVAAHFTHFIQGLLLCVPGETPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Y0</accession>
    <name>A0A914Y4Y0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Y0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14292.t1">
        <property type="protein sequence ID" value="PSU_v2.g14292.t1"/>
        <property type="gene ID" value="PSU_v2.g14292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14292.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8053" checksum="654AFE5972B1BEBC" modified="2023-02-22" version="1">MQLRPKIIRCNIDNLGLLYPCTLTFKEYKFLTTNIGHLTLGNTIVKDENDQVVPVEDLLACIPNCYHFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5K0</accession>
    <name>A0A914Y5K0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase</fullName>
            <ecNumber evidence="5">3.5.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peptide:N-glycanase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.</text>
            <dbReference type="EC" id="3.5.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.52" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y5K0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14714.t1">
        <property type="protein sequence ID" value="PSU_v2.g14714.t1"/>
        <property type="gene ID" value="PSU_v2.g14714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1020">
        <property type="entry name" value="Peptide N glycanase, PAW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038680">
        <property type="entry name" value="PAW_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006588">
        <property type="entry name" value="Peptide_N_glycanase_PAW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04721">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51398">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PAW" evidence="13">
        <location>
            <begin position="172"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14714.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="42452" checksum="C55F266D9F23E668" modified="2023-02-22" version="1">MLKKEKMMLNVPIKLLETRNGRCGEWANCFALICRAIGLETRYIMDNLDHVWVEIWAQELDRWVHCDPCENVMDTPLMYESGWNKKYAYVIAFAKDHVMDVTWRYTFDRKVTSKRRTQCRPAVFYNFITKLSNRLAKNLPQERQKELQRRYLCEMIEFLWPQNNKRDGSEAETHGRISGSKQWREARCETTNSACVIKPTTNEIDAKCLEIHYNSATDEYRRPHDASTSKGFKSLAFESKNVFRKVEIDWKKAYLCRTEGSEKGELVWKIEFNGEKPKSVTINFGEPFCRDNGNVLGVVCCGEQCVRVNDTVTLNEFSDDATYLEFRIEMSGGKGNNAWQHAQILRCDLDNTKTNFSIRVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6G6</accession>
    <name>A0A914Y6G6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y6G6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14352.t1">
        <property type="protein sequence ID" value="PSU_v2.g14352.t1"/>
        <property type="gene ID" value="PSU_v2.g14352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14352.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="25692" checksum="4D442DD69161B363" modified="2023-02-22" version="1">MSFRGGRGGGGGRGGGGGRGGGFGGGGRGGRGGGFGGGRGGGGRGFDNGPPSEVTEAGFFSHPCENDLVVWSTSGKIPFFNANIYFENIEPIGKVDEIFGGPAENGFTVKLNDGLKTKSFKKDQKVYIDPAKLLPVERFTNPSAGGRGRGRGGDRGAGGRGGGRGFGGDRGGRGGGRGNFNDRRGGFDRGGRGGGRGGFSDRGGRGGFDRGGRGGGRGGFNDRGGSRGGAGFGQKRFGNNDNNTPQNKRIKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y724</accession>
    <name>A0A914Y724_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y724"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15254.t1">
        <property type="protein sequence ID" value="PSU_v2.g15254.t1"/>
        <property type="gene ID" value="PSU_v2.g15254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15254.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9456" checksum="636838E85E1FADFD" modified="2023-02-22" version="1">MNLQSVAKDADVELLRWSFSEPQTGKSGSDRKAAVVKERLRAFVDDRHDVTSEEDVFTGLTVPDILPHATIVHAEVEILEKAEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7I1</accession>
    <name>A0A914Y7I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7I1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14706.t1">
        <property type="protein sequence ID" value="PSU_v2.g14706.t1"/>
        <property type="gene ID" value="PSU_v2.g14706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14706.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10705" checksum="5D1A41969CD5D98E" modified="2023-02-22" version="1">MENLSKLWITDYLSVYTANDSNNSVVLNFPKIYQCDATYLLLKNQVISLNEFMFLCLSVEELGLEEVTVKNDNGTVVLFDKLAEQFPNVKEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7X4</accession>
    <name>A0A914Y7X4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7X4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15374.t1">
        <property type="protein sequence ID" value="PSU_v2.g15374.t1"/>
        <property type="gene ID" value="PSU_v2.g15374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15374.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23244" checksum="294BD08288413439" modified="2023-02-22" version="1">MTIQSKRDQEKIKERFSNKEPLPGRKRARSVFNDTLDNANDTIAETTISNTTSSARSRRTRTLINPNYREDNNLNESRNTLKRKDESRLSESFDHLSNISFSTPSSTGYQEVPSSAWNYGYDSLGRFQKRIIVMDLNDKKYAHEYGIYKGCGTRCLGCYRVKNSYRNAKFDNQKKLFVPTNHLCTPKLYAEIKEEQKKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8B8</accession>
    <name>A0A914Y8B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8B8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1569.t1">
        <property type="protein sequence ID" value="PSU_v2.g1569.t1"/>
        <property type="gene ID" value="PSU_v2.g1569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1569.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9526" checksum="9E02F75F7405BBF0" modified="2023-02-22" version="1">MEVFKFAIEYDIDDILDACCTFFEKFVNSTNVCDYIQIAYSNNFEELKKKCLKFLIEKKKEIDSSKVADLPKNILSDLLTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8S5</accession>
    <name>A0A914Y8S5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8S5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15857.t1">
        <property type="protein sequence ID" value="PSU_v2.g15857.t1"/>
        <property type="gene ID" value="PSU_v2.g15857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF37">
        <property type="entry name" value="TARGET OF EGR1 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15857.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22631" checksum="C511BE77E5AF65FD" modified="2023-02-22" version="1">MSNDNYIVEPDALAFLSKHGFDFNRLINSAILYSIKDRTGPLPILLKDILSSGASVIFHNGFVDLAFLYHHFFNEIPETVGVFQSNVYDWFTTEGIDSGTFGGRGLFFDSKFAAASDQYFSTFLEYVFRKSQRSNVLEYRDNRLYVRVKFSKDYGSAEIDASDIDVVDCSMSPHFLKNNFALNKESTDSLCPFYAVSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y972</accession>
    <name>A0A914Y972_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y972"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16744.t1">
        <property type="protein sequence ID" value="PSU_v2.g16744.t1"/>
        <property type="gene ID" value="PSU_v2.g16744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF96">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16744.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11483" checksum="C92171FEBADFC9DC" modified="2023-02-22" version="1">MLEKSLLKDIWSVTVALFFVGAICGSLSINGLAEKLGRKRALIFTYILSYISLFLAILSYFINAFELYAFIYPLDPCIYLKYLPDIFGVCWDVNGIAVQLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9F4</accession>
    <name>A0A914Y9F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9F4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16829.t1">
        <property type="protein sequence ID" value="PSU_v2.g16829.t1"/>
        <property type="gene ID" value="PSU_v2.g16829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16829.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8080" checksum="9DD4664F23117AFD" modified="2023-02-22" version="1">MKNLDGCDKTPIYIAFVEKKPVIGKAAMEVYGKEPQFVVYDLIKLCSISSADVTNTNWGFRLSKENEKFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBS8</accession>
    <name>A0A914YBS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16743.t1">
        <property type="protein sequence ID" value="PSU_v2.g16743.t1"/>
        <property type="gene ID" value="PSU_v2.g16743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16743.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26372" checksum="84CC9AB9625F0ED5" modified="2023-02-22" version="1">MSIFSPKHAKEVVNAGGISPFIYLIDSNNLAMKEESLWALQAIAHRNKKDRDYAIANGIISKIVKIVMFDEPAMNIEHRVAELIKAILVHSDISIPALKELLPAINKLLSSNNDEVISQILQSLYFTIKNDEISQLFLDDGIAEKLVPFLNSENSKFRAIALPVIGNLCYSKPEKIKIFLDLGILKFLPKLLNHKDTRENALLLKSTMKSDEELKEILNDYEINEIQNTKMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBW4</accession>
    <name>A0A914YBW4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBW4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14970.t1">
        <property type="protein sequence ID" value="PSU_v2.g14970.t1"/>
        <property type="gene ID" value="PSU_v2.g14970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037573028" evidence="1">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14970.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7230" checksum="60C9F25057DBD62C" modified="2023-02-22" version="1">MAGCISCFMTASLAGVLVEDAKYCDNSVESHCFNVAEYIEIMDNNFTSYANSSSSGQAFLPFREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC14</accession>
    <name>A0A914YC14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NTR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YC14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16968.t1">
        <property type="protein sequence ID" value="PSU_v2.g16968.t1"/>
        <property type="gene ID" value="PSU_v2.g16968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03577">
        <property type="entry name" value="NTR_TIMP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF29">
        <property type="entry name" value="METALLOPROTEINASE INHIBITOR TAG-225-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="NTR" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16968.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12459" checksum="F2D3BF7372B27379" modified="2023-02-22" version="1">MPESSSRAGLNNIRYNVEYGKIFKSPADLNGELPKEIYTPSERPACGLLMDAGKEYLLAGRYENGTMTTVLCGQILSDDPNKESFENVLEWKNVPNSLRNRLDIKAFEPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCK1</accession>
    <name>A0A914YCK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCK1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17023.t1">
        <property type="protein sequence ID" value="PSU_v2.g17023.t1"/>
        <property type="gene ID" value="PSU_v2.g17023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF13">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17023.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29113" checksum="241C035FC567739C" modified="2023-02-22" version="1">MVKPGRTLGHAPPARDQYRIGISEDLGMEHLWDPDDDKFKVLCRMIHVTKAALHIGYVQMMISFVFSLFFGYHYLMAISGNVSTEHWINQYTARYVSQLLFAVAVQLCLVVVMIHGVRSEKRCFLLPYIVFAAIAIIAGCAQLGNDFVNVERNNNIRGNNANTSQFISHLIATMIHAWCLSVVWRCYGYLGEKKVARQISEQLNATHAAFHYPDQFFGYVQMPQPPPYADTVISAPKQNASRSIIKMEEDKQPLTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCK6</accession>
    <name>A0A914YCK6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="4">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">NADP(+)-specific ICDH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YCK6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15203.t1">
        <property type="protein sequence ID" value="PSU_v2.g15203.t1"/>
        <property type="gene ID" value="PSU_v2.g15203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15203.t1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36454" checksum="4D009153EB352DB3" modified="2023-02-22" version="1">MWKSPNGTIRNILGGTVFREPIICKNVPRLVTTWTKPIIIGRHAHADQYKATDFVVPGAGKLELRFVPDNGGETVNHEVYQFSGPGVAIGMYNTDESIRHFAHASFVYALDREYPLYLSTKNTILKKYDGRFKDIFQEIYESEYRKKYEAKGIWYEHRLIDDMVAQAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVEAEAAHGTVTRHYRQHQKGEETSTNPIASIFAWTRGLEHRAKLDNNEALKNFASNLEAVCIETIESGFMTKDLAICVKGTNKVDRKDYLNTFEFLDKIASNLVQKQKSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCX3</accession>
    <name>A0A914YCX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18085.t1">
        <property type="protein sequence ID" value="PSU_v2.g18085.t1"/>
        <property type="gene ID" value="PSU_v2.g18085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18085.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9047" checksum="BB00D073825D9F58" modified="2023-02-22" version="1">MLERWTYEFCYNNQVDTSVLDKPSLLSTAEKYAKNGRELLEMFFETGGSFNFFEDVEIRSSKVNYSNNSCLRGKNIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD30</accession>
    <name>A0A914YD30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18131.t1">
        <property type="protein sequence ID" value="PSU_v2.g18131.t1"/>
        <property type="gene ID" value="PSU_v2.g18131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18131.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15192" checksum="5FA5F3890203DFB1" modified="2023-02-22" version="1">MSFCEPNDNEEDLSLIFSDLGISYTELNIKNIQEFITLKCCRKRYITILTSDNQIAFINSEMLENASIFIKSFIESKEPLKINFSSKIVNIAINLWYGKECQEFEGNEIEVFEFAKEFNIKSVKDKCIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD61</accession>
    <name>A0A914YD61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17233.t1">
        <property type="protein sequence ID" value="PSU_v2.g17233.t1"/>
        <property type="gene ID" value="PSU_v2.g17233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17233.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27484" checksum="FE3FDF4A350F0B0D" modified="2023-02-22" version="1">MSDNQKTCADNVDGEKLIDGCSFTVKWLLESLRKNDKEFQQKFGNKNVKKVTAYDISDGRGVASVVLRCTVFFTDSDESYSTILKVPGLEVFKQVQIKYNGKCDMLDESLIKRFNVNHQKECKFYNIMAPLLKGSIPKVYKTEDWILNEKERCVHMEDLSQKGKTFTYFESVNLNQIKSFVRNLAKIHKSNLVADEKIWKGKFVEDDQFFTFYHEILETQIEPFLKTCSRESKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDU5</accession>
    <name>A0A914YDU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17470.t1">
        <property type="protein sequence ID" value="PSU_v2.g17470.t1"/>
        <property type="gene ID" value="PSU_v2.g17470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17470.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15656" checksum="285AA06D56A5660A" modified="2023-02-22" version="1">MRYDEFYKLITLKMDVIGKAREESYNKLHKAVEGMPPNDPAFCETVKTLIETEKNLQDMMKVVNVVVDRQLEAYDAVNTLALELPKKRQEGKQMNGKQRVKFVDEIQDGEEADDGTYDVEKNSEEDKSIMAFSGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDV1</accession>
    <name>A0A914YDV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17607.t1">
        <property type="protein sequence ID" value="PSU_v2.g17607.t1"/>
        <property type="gene ID" value="PSU_v2.g17607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17607.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="14499" checksum="BD39C26108E1000A" modified="2023-02-22" version="1">MGLVGGSIFHSFNGYRHAPKGRLVNSMIREICTKSAVTGVQFAAWGGMFSAIDCSLVAIRKKEDPLNSIASGSLTGALLAIRSGPKVMAGSAVLGGIILAMIEGVGLVSSRWMSSMYDPTQQLSPPPDDYNDPNVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEQ8</accession>
    <name>A0A914YEQ8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malate dehydrogenase</fullName>
            <ecNumber evidence="11">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914YEQ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18753.t1">
        <property type="protein sequence ID" value="PSU_v2.g18753.t1"/>
        <property type="gene ID" value="PSU_v2.g18753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="172"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="33"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18753.t1"/>
        </source>
    </evidence>
    <sequence length="338" mass="34976" checksum="A6ECD524254CE6DB" modified="2023-02-22" version="1">MAFASKTVLNAASGICRLSVRNTSSAPKVALLGASGGIGQPLGLLLKTNPKVASLALYDVANTAGVGADLSHIDTAAQVTSHTGPENLHAALEGADIVVIPAGVPRKPGMTRDDLFNVNAGIVRDLAEAAAKACPKAFVAIITNPVNSTVPIAAEVYKNNGVYDPKRIFGVTTLDVVRSQAFISELKKLDVSKTVIPVIGGHSGVTIIPLLSQVQPSAQFSDSEIEKLTARIQDAGTEVVKAKAGAGSATLSMAFAGARFVDALISGLQGKKNVQCSFVESDVVKGVDYFSTPLELGPNGVEKILGYGKLSSYEQSLVEAAVPELQKNIAKGVKFIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFI0</accession>
    <name>A0A914YFI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFI0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18206.t1">
        <property type="protein sequence ID" value="PSU_v2.g18206.t1"/>
        <property type="gene ID" value="PSU_v2.g18206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18206.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16053" checksum="3734C707B7668253" modified="2023-02-22" version="1">MYMTDISLSPANEYYTNISISRQFAWSSDPSLYYQNVSSWPGCSTIDGDCSFVYQDGVIWQSYNVMMAGELVVFDLMTWYMIDQGTYYGLYETFDPKQPPCLPDVGGNANFTGRYTYCCTKFTYFTIPDNDPINRYKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFY2</accession>
    <name>A0A914YFY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucan biosynthesis periplasmic MdoG C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFY2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18225.t1">
        <property type="protein sequence ID" value="PSU_v2.g18225.t1"/>
        <property type="gene ID" value="PSU_v2.g18225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051274">
        <property type="term" value="P:beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014438">
        <property type="entry name" value="Glucan_biosyn_MdoG/MdoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007444">
        <property type="entry name" value="Glucan_biosyn_MdoG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30504">
        <property type="entry name" value="GLUCANS BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30504:SF3">
        <property type="entry name" value="GLUCANS BIOSYNTHESIS PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04349">
        <property type="entry name" value="MdoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucan biosynthesis periplasmic MdoG C-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18225.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24796" checksum="B7786C0D2648C605" modified="2023-02-22" version="1">MDRRRFIKGSMAMAAVCGTSGIASLFSQAAFAADSDIADGQTQRFDFSILQSMAHDLAQTAWRGAPRPLPDTLATMTPQAYNSIQYDAEKSLWHNVENRQLDAQFFHMGMGFRRRVRMFSVDPATHLAREIHFRPELFKYNDAGVDTKQLEGQSDLGFAGFRVFKAPELARRDVVSFLGASYFRAVDDTYQYGLSARGLAIDTYTDSKEEFPDLPPSGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGK1</accession>
    <name>A0A914YGK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGK1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18445.t1">
        <property type="protein sequence ID" value="PSU_v2.g18445.t1"/>
        <property type="gene ID" value="PSU_v2.g18445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0868">Chloride</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18445.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24497" checksum="E30EC841C1C2B52D" modified="2023-02-22" version="1">MPDKIVVPAFSKTSLYKVHSLFSLLDLNRAYVTDRGRLVGVVALRDLRIAIQQAANGIQPIKQQHGEFIEEEPNVLDIEKGFINGPPKSPRLDHPHPEFAQHFVAGMELQRSAEEDVVQHNDILTPALKVVHPSSASLHHYNNHPLLTIQEENDATSLKSAPHSYERPSSPPRTSILKKKEPPLQKRDQVAKAVAYLRRKSISLDKTNDDLLPGREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHQ7</accession>
    <name>A0A914YHQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHQ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18853.t1">
        <property type="protein sequence ID" value="PSU_v2.g18853.t1"/>
        <property type="gene ID" value="PSU_v2.g18853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF32">
        <property type="entry name" value="GST_C_6 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18853.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19122" checksum="C0D49DB8718D6E26" modified="2023-02-22" version="1">MLEENLDTEQRGIARAVDRMIDTSTSRALTYFRVFENATNLFNPNVSGLPIPGFLSFIPRNAYYKAASRQLYSEGIGKHPREEVVEILRRDLQAIDDILGDKKFLLGIRPTIPDFTMFGHLASCYYLPFRQPVTDLIDDNFPRIREHLDRMRIHYWSDWKRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI96</accession>
    <name>A0A914YI96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18532.t1">
        <property type="protein sequence ID" value="PSU_v2.g18532.t1"/>
        <property type="gene ID" value="PSU_v2.g18532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18532.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="33550" checksum="BAAF1CC9860B8FD8" modified="2023-02-22" version="1">MQLDDLKMQCERSKREATESKAEFKKLQEIAEKYISQSEKDAAQEKKRADETILEAKKINAELLKANAEVLQLQKKLKEEQEIVEKVNLKSNENDEKILNIKNWYENEMKQARMREQQLENEILEYRKQINELKENGALQLEEAENQLQETKESFQLKIHKLNEVGKMRYEKYVNLKNQLKDVTQKLGNKSTEKEQEILETSSQIKTLKDEVVKYQNWINLKDQIIEDLQKQISIQQTLNAKNIEESQKTAEKLKNLYSTVTNLEKELMDEKKSSKVNLKKTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIB9</accession>
    <name>A0A914YIB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NFX1-type zinc finger-containing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18559.t1">
        <property type="protein sequence ID" value="PSU_v2.g18559.t1"/>
        <property type="gene ID" value="PSU_v2.g18559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18559.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39607" checksum="6208B033EDBC885C" modified="2023-02-22" version="1">MVTREIPNCRHVVEIHCSADVNVVKCHAEVQKEWPLCKHITTAKCSDDVSKIPCKQPCNASLPDCGHKCKGTCGECRNGRIHIKCTESCKKILICGHECEEKCSKVCPPCLKLCETACGHSQCGNLSIKGERQKKVRKILDDKNSKKRGRTCGEPCPPCKEPCLNICEHRQCDLVCGDPCTVFPCSEPCEKLLECDPSKKGKNVEDPDYVPHLCIGICGDDCPKICKICDPKIFAAIKETFLGYEEEENARFVQLKDCKHMIEVQGLDQWIESLLPNPEENEAATEIVKINCPKCKTPIRRSKRYISLLNQRAIDIENIKQIIRGLTFEEKIAENEKFGKEVVEAFESIEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ08</accession>
    <name>A0A914YJ08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJ08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19496.t1">
        <property type="protein sequence ID" value="PSU_v2.g19496.t1"/>
        <property type="gene ID" value="PSU_v2.g19496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="entry name" value="YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050423">
        <property type="entry name" value="UPF0337_stress_rsp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026042">
        <property type="entry name" value="YjbJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34977">
        <property type="entry name" value="UPF0337 PROTEIN YJBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34977:SF1">
        <property type="entry name" value="UPF0337 PROTEIN YJBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039008">
        <property type="entry name" value="YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19496.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8445" checksum="48678070D83AD297" modified="2023-02-22" version="1">MNKDIISGKWSQLKGKAQAKWGDLTNDDFDVAEGNAEYLAGRLQERYGWAKDRAEKEVREFQDAVSKDYPDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJA0</accession>
    <name>A0A914YJA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17393.t1">
        <property type="protein sequence ID" value="PSU_v2.g17393.t1"/>
        <property type="gene ID" value="PSU_v2.g17393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17393.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12493" checksum="E2F8CFE32EF8171F" modified="2023-02-22" version="1">MFAYYKVSHSAEFRLIIKKEDERGEQVIFEAPRTTIESRRWFREIRKLEIGRYNYITFEVRNLPANAYVGIDEFLILNESQQPFCSVIPESRFIESFVDPTIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJJ9</accession>
    <name>A0A914YJJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJJ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19698.t1">
        <property type="protein sequence ID" value="PSU_v2.g19698.t1"/>
        <property type="gene ID" value="PSU_v2.g19698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF14">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19698.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12164" checksum="0EC53FEA60E6BB2B" modified="2023-02-22" version="1">MASHTVTTSAGIKMPRFIYGTAWKKDRTTELVVKAVLNGFRGIDTACQPKHYQEDLVGQALVTLQKEHNISRESLFVQTKFTSIDGQDPQKIPYDRNAPLPDQLCMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKL0</accession>
    <name>A0A914YKL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FOXP coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YKL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19415.t1">
        <property type="protein sequence ID" value="PSU_v2.g19415.t1"/>
        <property type="gene ID" value="PSU_v2.g19415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FOXP coiled-coil" evidence="6">
        <location>
            <begin position="270"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19415.t1"/>
        </source>
    </evidence>
    <sequence length="426" mass="45003" checksum="386A6710B8C449E9" modified="2023-02-22" version="1">MATVSKVKSPPQPFGSQKIRRTASVADLTPNKGRGLLSGSSSAFHKPIINFDNFHSSQGQPSSRQQPTVTNAVSALTPTTLIYSQSSSSTGGHHNNSNHHYHIPTTQSSSNNLVENLAAAAAAAAAAAGSGVQQQQQHQSLTSSNQLGSASTTPGLSATLENVAALASLAGHNSQQNLQIEQLLMLAIQERVAQQLVASPIDRLWQNMLSLGGAATPNTGMPSPLDLSAAIPGAQSSNTSALSSLSNLSALLTPNANTSSLNHPQSTHSLYQHGMCIWPQCNTPCNSYGSFIHHLSQAHSPERSTHQYRAQIELVDDLEHRIVKEKQLLNAMKAHMHMKLSPELSRHSVGPPTSNDVSPLVSPKPTIATTPIGYPSSSSAPTSSIPQNIIKNDNISGHSGPTNLITSTISGVNLNAVSRFYHLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL86</accession>
    <name>A0A914YL86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19649.t1">
        <property type="protein sequence ID" value="PSU_v2.g19649.t1"/>
        <property type="gene ID" value="PSU_v2.g19649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19649.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18186" checksum="CB001C8F68F70763" modified="2023-02-22" version="1">MHKYNHYYTSRGFKYLCRASKYITEDEYQNECKKIIDGKKFHDGPVHAVTADFGVLESIVESEARNFKVTSFFQFLLNLYDSNPAIFIGTQLWSMRQAVYIAEIMAALLCLKHAQNATVTNSFLDQITQMFESVIGAGTVFEAFQQIRQTYGLEGALTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNK2</accession>
    <name>A0A914YNK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20992.t1">
        <property type="protein sequence ID" value="PSU_v2.g20992.t1"/>
        <property type="gene ID" value="PSU_v2.g20992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20992.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10588" checksum="B2F52E651F512ED4" modified="2023-02-22" version="1">MSETPLLSLTTSSQEESESLQLTGRILGSAEFHYFASKTKLSMDCLNKSLDKAVMLLKLSENVKELKAEMDKFRANIDHLAETNDSSALSELSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP18</accession>
    <name>A0A914YP18_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YP18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21366.t1">
        <property type="protein sequence ID" value="PSU_v2.g21366.t1"/>
        <property type="gene ID" value="PSU_v2.g21366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF112">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="75"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21366.t1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44745" checksum="B4DFA90BE0E2F53D" modified="2023-02-22" version="1">MNAGYLPNEAIEIFGSNLTKFEKVEILNYERIYFIGSETARKNKHGILSMVQNNKFDDENGHLILLLHDHIGYRYEIIELIGKGSFGQVVKALDHKTHQFVAIKLSQKNVTNMFEKEIQILEHLQDSEGGSKYINQMIEAFNFRNHKCITFELMEMNMYQRIKLFNFRGFDIRVVANFARSLLKSLKFIHSKNIIHCDLKPENIMLKKKSISNLKIIDFGCSCFEGQTIYSYIQSRFYRAPEVIIGAKYGAPIDMWSLGCVLVELITGAPLFKGEDEFDQLACIIELLGMPPTKMIKNGKYSKKFFSSNGHPRYCSQTTLIDGTIFLENGISKSGKIRGIPASQSWRRATKNMADKLFIDFLKKCLVWDPDSRITASAALQHPWCKKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP95</accession>
    <name>A0A914YP95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP95"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21459.t1">
        <property type="protein sequence ID" value="PSU_v2.g21459.t1"/>
        <property type="gene ID" value="PSU_v2.g21459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024:SF3">
        <property type="entry name" value="C-TYPE LECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036917815" evidence="2">
        <location>
            <begin position="18"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="318"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21459.t1"/>
        </source>
    </evidence>
    <sequence length="664" mass="72614" checksum="C7C42097F6DFAA5B" modified="2023-02-22" version="1">MYLSKLLLLLFTTSILGKFIHHKAGYACQEPSSLSKYTPDCFVDLTVAIDMSLSMKSDSNIAKLADSILGDFMPSFNFKETYTAGLAFGALSIGASNYFNNYADICQYIHSAQEQAIQLGLGNANLSEVFETYQISLLNSGRNYKKVLVLLTSITDVKEIAAAKHYSDQLQASGVYIIVGVLGNASITLYSQLGNHVFSSPHFTLSVTNITENICQFGGITVTPAQSSTVHPTTAVPQTTHVKTSRPSIHPSTHPSTMPSTTTSSPPTTKKNPPTTKIPLPSSTASKISPPTPPHPTIISNHGIGTSCSKNVKNAWLDIALVFDVSAAITDGQLEQLIDETQTYILKFTLNQIGQHTTRVAIISYASDATITYSFNDNQSNQSFFDALQKLKNRTTPHNQIVNVQNALQVAFEHLLESSTYRPQVILLTAAAYQRKGFQGADHTAEQIKLNEITIFTVNFNAADGVLNGHLSGLASPGYAYNSSDVGLAEDLPLSLTQVNCFCPGSRVQFKIFNSISKRYTKYADCISGYAGETLPSIISKYGCDSGILAAITSEEKLDFVIKNILEHELFGKNQFTVGGHKIGNNEWVWSGYNGTFPFEDFPPFTEVSPSDKYTFFNILPESTNGFTFKSTGDVARPYLCESRACDADYICDQSVEKKIFKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPB1</accession>
    <name>A0A914YPB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPB1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21269.t1">
        <property type="protein sequence ID" value="PSU_v2.g21269.t1"/>
        <property type="gene ID" value="PSU_v2.g21269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036973468" evidence="1">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21269.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15813" checksum="0677D99BD5B79BAE" modified="2023-02-22" version="1">MQSFLLVFVVATTFFPIVASIVALDFATPYTSFPIGCHTFEGKISCGNGNPILSDAKITLFDKDFITGDDKLVEDTPHGGVFVIHKCATDFPTPNLELYFQFVNICQKGDKKQSGILKENAFMEYVIYDNEKFAHTAINDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPI4</accession>
    <name>A0A914YPI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g21540.t1">
        <property type="protein sequence ID" value="PSU_v2.g21540.t1"/>
        <property type="gene ID" value="PSU_v2.g21540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21540.t1"/>
        </source>
    </evidence>
    <sequence length="1465" mass="161202" checksum="7F98C937D1C2F3FE" modified="2023-02-22" version="1">MDGKKDCFDGSDEDKDYVRLLTSCLYPPKSPSNIPNNGFIPQQPTGLNLPTNANNFIPSPTSPSLLLPNNQYPGGGGSYARITRPPTFPWKPPQETTDKYSPFSISNELVPINPFVRGPLTLKPPNNGETINPTISTSIETETNNYGQGEIDNYGLPDFGQNGVQSGGGIYGAPITPIIPVNKFTKPPYPFEEGSKVTGPNTKGRHTTKRPGDQPGESEETNEKEPTEKPPWINIATFPPPKHTHPTVSPHSTKQTINPEDEWIIQPIEGIPSIPNESTKPHPTEHPTQRPSPIHPSTKYRTKATPLPHRTRTRPSSTSPATSVSEFIPTKFETVVSDPYYFAQGIDSQLTTSSSPQSLNCTEKIKKAANELVPHPICECPAGQMKTKDGQCVKAEISTFRARLLHLCNVGVRDNYVENEAQILTWKLAATFDYPVCVRKADDIIIFNTVCNGCEFSDLIDRYASNNDLSEIDVKLSELQKSGCYEFVINDCDEKAECIPDGLRYRCKCLPGTTDSDGTGRFCSGVVIANECVKIFGLCVLFWIILLLLLALLLPIIGYLLWKYCKKRNYKVFDRFSKKKNQTDIALTPRTGNIEAGGEITGVTTESSGAQWEGYNRGNIPTITTTNATTPRSTPLNQHIPADEYSIIENEDDDEKDSSKGDNESLAASTDSTTALHKPALEARVITSPDRRSSTGSRSATPTIWETYKILGQQYTTSGSERRKSSTHSLEMLIRKRQEEELKKRATAMSLPDVDIGVSSKPPIGKERGSIESARSAEAEQAAKLAEMLGVDTSTVAKVEEVKDVSILNVAGEPPTAEVATIEEKLHEQRQFSAIVPEINLGSVPSTPEIIKAAENAVNDALKNVMGSHYEPPDTTVNTSQSAQTAIDERLQTTTKASPTGSREDLPIIGNEAPQRPPSGNSIRSRSALPNPTIESTDITEELDKVAEALSQLPALPVSSLSKNEENKRKIKTSKTQPSTARGSKTSFDLVPKSARSLNAEKLPKIMGSPTRNSQKTISSTMKEKPTIKRTRSSKSVISDDIPSTAGTIVIKPKSALSSPATPKKNMVTKPKFRPIASSSLSGTQLPPIAPKRKLPPVPRQPSSTSLKPKKFLSNPSTRQLSNISENSDGTPSKSSITLSKQIPHSVSLPNTARSGKSKLPRLVDAKKVNENNHNYDEPNYILADLDLDLPGPFMVPGSLEDLRNVGFGTSKLPHLDKNVSTQSAPSTDRRGKSSEILNRQQSTKSDEFWKYNTLPPIDVDLEDLSVPDFDIDTSRTEKPIRHSTIARKIASRKAAGQNYPLQKPTFQQQQQQHKDKDKDKDKEDIDIVYEYRRPRSNSSHIHDGCLINQPPWDSTPLKEGELDQIPLDWNLSRSSSLLSFTDRKTQSFTDLHKITTMQVTTTSTKTNTNLSRTKSESGTSLTNVFHFKAKIKNNNNNNGNGNDVDWIDDIKKSLGQTNSWLDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPJ8</accession>
    <name>A0A914YPJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20926.t1">
        <property type="protein sequence ID" value="PSU_v2.g20926.t1"/>
        <property type="gene ID" value="PSU_v2.g20926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037594720" evidence="1">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20926.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27887" checksum="D6E19AC5236DB4AE" modified="2023-02-22" version="1">MIFLKFLSAFLVLFVASVAGQGIYVTLPPLLAGYNINENQERFARQMQAAIQNPYENGYNYNNNNGLQQGYGGSIYDQFSGKSTLDRQNGQIPLNPFEKRPNSGGFKYPSQFFAAQNAARREDQQNVNKEYVNPGYEFGNYPNGPGYLIKNYVNQGQYRVKPQPYEPEFYTTTATSLSISQSQGIARERENEKWQNLRTYGIKTNQEPQGLLQEQLREPWNQSYENQVGLTEHIQQIASRGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ36</accession>
    <name>A0A914YQ36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maturase K</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19479.t1">
        <property type="protein sequence ID" value="PSU_v2.g19479.t1"/>
        <property type="gene ID" value="PSU_v2.g19479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19479.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35581" checksum="BEF12265C81A0E98" modified="2023-02-22" version="1">MVTSNLFHMINLLITKSNSNSTLFLTCEIFLALIGLSLETEDIISGKELLQITTIFVLALKSRDSSDDSFQLLSRTFLHFVGLLFSKFYQIMIQRNSAPLSQLEQKGMIILPSLCCIESYWDSFDDKLSPSDSYLSKSNLLDFSIVRKNIKLLGHLLYFYVGTLNISVKRANNETASENIYVLPEIILCCMGSRFPVKTAPLQLNTTQKYSETFKTFLIRVLLVQDLLARMVKKEYFGINSFYEYCPGLYGNEISRHIYTLFESNDQQHKRYPMRAQQNIPKVTPVYPVGVIPPHYISPRNGVWIKDGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQB8</accession>
    <name>A0A914YQB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21230.t1">
        <property type="protein sequence ID" value="PSU_v2.g21230.t1"/>
        <property type="gene ID" value="PSU_v2.g21230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21230.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8741" checksum="273A28E161CA71CE" modified="2023-02-22" version="1">MKEIQPLWFTPLFQRYIEGEIQFYANITQLEYEEFAKYRDEDNEYIVDIGIAVKEFNIHDEFYFEFQLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQT0</accession>
    <name>A0A914YQT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HSF-type DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQT0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3141.t1">
        <property type="protein sequence ID" value="PSU_v2.g3141.t1"/>
        <property type="gene ID" value="PSU_v2.g3141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3141.t1"/>
        </source>
    </evidence>
    <sequence length="467" mass="54232" checksum="33D5A4CE44E36EA2" modified="2023-02-22" version="1">MNAHFPEDVHVPWMSAEAIKTLPVFLVKLIRMLEDRNLDEFICWDRSGTSFHILDAPRFCDNVLPHYFKHRNLNSFVRQLNFYGFRKLAAADRATLTQIESPSDDLHFMHPKFIRGRSTLMYGIKRQTNPTKKLTAVAADKTVTTANTPLDGQFVSVPHQEWVDTNNKLTDLQGRHDELQFTVESMDKSQHLLFEEIRILREMCKKQSDCFNKLMSYLVTMMNPAKRVHRRPRHYDPYVDNSEENFAITTRNGGDMLALIQKEFQEGLHISKQSIFDEGQKDVQFEYYEPAEFYNEQSFDPLHGQETSLPPTLEKQNNQQLALTRPKQTYHFLPQKPKTEIHVSPSRLNKIQPTSLMSEIEQHPSTSYVMSEEPYGYYEDAPLEFLEQRTPPAPGESPIYLSKVEPIIGNPQYDGEYDDGNEQYDDGENEHEQQAEDLDDMMDILEGVPFHLEGDGHEWAQNSMAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQT2</accession>
    <name>A0A914YQT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQT2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2379.t1">
        <property type="protein sequence ID" value="PSU_v2.g2379.t1"/>
        <property type="gene ID" value="PSU_v2.g2379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44115:SF4">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44115">
        <property type="entry name" value="PROTEIN CBG09704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2379.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21380" checksum="5AA37304B3799DF5" modified="2023-02-22" version="1">MDFVTDGLKKTFDAILAAGVPKDRIHSVKGSITDSEVQKSLINETVQKFGKIDVLINNAGGVKNDEKDQRSMASLDYCLEVNLKAIPFYCIAKAALDHFARNYAAILAPQGIRINNLNPGLTDTAGVKRSGASDEMIQKMRNFYISQIPFRRAAASEEMGEFILFMASEKASYMTGQCINVDGGMLINSPSIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRL5</accession>
    <name>A0A914YRL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRL5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3401.t1">
        <property type="protein sequence ID" value="PSU_v2.g3401.t1"/>
        <property type="gene ID" value="PSU_v2.g3401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="124"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3401.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36481" checksum="882D5C300EF150AA" modified="2023-02-22" version="1">MVFLSADLKCMEIYAYRTLKGCNLTLKLDFLKIFSNDKKYAYCWAKYFKISDKKLPDFLKNCGCYNKDAKKFIEKLNDILFSLDEDCIVTRKIWGKFHKIITIVTPVAVVDFILEYFAKSKPKIMGIDCEAGFIDGKQKITVLQLATTDWLCLIDIGMLADKYSDNQWKTFFEHIFHPDIIRVGFSFSSDYNYICNRFPFLQSMLHEKERNVLCLQKLMNQNRFNNEFNSIFKKDIATNCGLATLAKEVLGITMNKKLQSTNWEKRPLTDDQKIYAVADALAALLIYERIETLLKQKFGNVKAMEKACYLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRT9</accession>
    <name>A0A914YRT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRT9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2889.t1">
        <property type="protein sequence ID" value="PSU_v2.g2889.t1"/>
        <property type="gene ID" value="PSU_v2.g2889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2889.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="23422" checksum="3F234ECCEAFD8EAF" modified="2023-02-22" version="1">MQKLSLLLHLKELCGTQTTTKKVTNVIAREGKAANPGAKTKTTATATKIEKKVEKTKKLGKKKIKEVIKEEGAVIAGGTVAAAGTIIAASEIIKHKSPTPSPSPPPPPPPPPPPKTPVKSPSPKDSPRPMTAASKKDESEEDEKEESDRESIVHHHEEEADNNESSEGHSETASETDEEEEVDHIERTESEGSGRPGTAVSKASRRGSLKSNKSIKSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRU9</accession>
    <name>A0A914YRU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRU9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g29.t1">
        <property type="protein sequence ID" value="PSU_v2.g29.t1"/>
        <property type="gene ID" value="PSU_v2.g29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g29.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32873" checksum="38063B44E61B9B3C" modified="2023-02-22" version="1">MLCEICFEEYGSEEFQHLACGHTFCNTCLSMCTATVLCPHLMCPAVRSMDIVVQEADAPLDPDLMDDQDNDAVEKHQNRIAFAARLPLVMRLEEKIRCDGRKGQFQCFNVARITYSCRHSTCFDCFGKRLTLIAKYNDPPTCPTQRCSNRLTKTEIKKMSERSGFAEICAKILNSMRDDLPREDRVPGKDEVRVYCSIYGNDPSTKLMYIPIVCTFGDMINAFMQVLRIDKTFVSSELHIYVQTITESGKTKFEQLNLKQLSRKSIRDSIIADKTHVVFDLKSEIGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSL4</accession>
    <name>A0A914YSL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3002.t1">
        <property type="protein sequence ID" value="PSU_v2.g3002.t1"/>
        <property type="gene ID" value="PSU_v2.g3002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3002.t1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41518" checksum="394044B1FC8B4B98" modified="2023-02-22" version="1">MVEKADNESKAALRRIKKKYYKMIIRRLPYEMTEEDLLQLLSPLPSHERFWFRKGEEYLEDDAFPYAFIIFDDFDEAAKFQKAYNGQLFTDSEGNESTVIVEKAANQDFSKEPLKPKPGVTPITEDIGFIQFLEEAESKSITKKVDFDVLVNEITERERRHAEGICQDTPLTDYFIKKAHEKIVKNRPKPKKLEPKGAKLEKGESRIIKANAKDKKENHGRGREPKYRGEPLPKEKDDARLNETAEKKKRERLPRRTFENRKAQKEAASNSENAGPSKEFIRKQNSSSPKTEAKEVQKAVSNNATAKEDEVPKERKLVGPSQRNKDRPERAIYQPGRGRRGKPTTTAPSSKAPNENVEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSZ8</accession>
    <name>A0A914YSZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSZ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3818.t1">
        <property type="protein sequence ID" value="PSU_v2.g3818.t1"/>
        <property type="gene ID" value="PSU_v2.g3818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3818.t1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20750" checksum="4A0CFA3C2C01C563" modified="2023-02-22" version="1">MPQQVNKTTYTAGTSTSSTAGSNAEVAKEKSTGNIEEGVKNAAHAIGIGSSHHHHDAHCNKATCTTYETETAHYTEVDDHARNARLLREQAEKTLKNNDKEIDEAQRAQVQARIVAEHANIETAEALTHQARGQELLAEAGAEIIEAGSKFPREAAANSHQAPYNVHAEGEVRQTIMVSSAGQEAALHAHEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT87</accession>
    <name>A0A914YT87_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YT87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3208.t1">
        <property type="protein sequence ID" value="PSU_v2.g3208.t1"/>
        <property type="gene ID" value="PSU_v2.g3208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3208.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9104" checksum="B84C17AAFBDD9403" modified="2023-02-22" version="1">MEQFDQLHCQQGIFVTCDSAMRELIKFLDATRALGSSFVIAELDENHLFLDARKVQDLEKVLEQRREELCPDLYDRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTC4</accession>
    <name>A0A914YTC4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1758 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g3938.t1">
        <property type="protein sequence ID" value="PSU_v2.g3938.t1"/>
        <property type="gene ID" value="PSU_v2.g3938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1758" evidence="2">
        <location>
            <begin position="493"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3938.t1"/>
        </source>
    </evidence>
    <sequence length="853" mass="98399" checksum="5F98D8B2A5C574BE" modified="2023-02-22" version="1">MSERIQIDLQRTVKEVLKIQHEYNEMLLTHPPPWSTLLNIRFKSKLQLMKQHHSFILQALEKWGDIAKKTKDFNDKKQEYHDLDEWRDKDENTTLLKELSEIIMEGSDYLTLEIDSDDDRSSINTNYSKENQNMITGTVPHINLPKFNGDYLKWDQFWQRFEHSVHSRPYHKIEKLISLLGYLEGKAMEEVEGFTVSEENYDTIIEILKDRFGKKPLIIKELQAKLRAIEPAKSNPESLRNTVNMICTMCRQLENXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRQLENYGVDIDNDSMKLDIIEKLPYREKEKLNWMLTSEPEKATIEELMKKMKDMALRAEVAPKKQIKPNFEPKHSNNFRSDITGNESVSSLKPTETVGKFKCSFCDDPQHKSSKCPKFISADSKLKQLQSRNCCTKCLNSNHDTKSCTAKLSCRFCQGDHYPFLCKNNDSIKSNAFITVEKKQGMLLTREVMVINPETKKSTETVVIFDSGSQQSYISNKLIEQLKLEKIQEEQLHVLGFGAKSLNYTSSLVKFQLKTINDCKEVYANSTNKIATTVPVVQTENLDFNDIKPIYKTPDLLIGMDYFFEFITSFEKIDNNLYTVNSTVGKMICKNVPKIHKTTVASLAIEQPEFLIEDENDLQKFWNLEQMGIKDNSENDEEAFVLEKFKKNIKFKDNRYYVSWPEKENHDILPTNAGLALGRFKSTIARISKVQNLMKDCDKIVADQNQKGTIEPAPKIPQGRLIHYLSPQAVITPNKTTTKVRIVFDASAKISKFAPSLNDCLIRGPLNMPDLGGILLRIRRGKYMLVGDIEKAFHQVYLNENDRDAYRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTI6</accession>
    <name>A0A914YTI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3998.t1">
        <property type="protein sequence ID" value="PSU_v2.g3998.t1"/>
        <property type="gene ID" value="PSU_v2.g3998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3998.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19050" checksum="3F17DF445DC25708" modified="2023-02-22" version="1">MAENNLLAAIKIPKYPPQSIFPSDVLKWMKCNAVAYPRQALKPFTDNNEKWYIKRLNDEWENEMEFNELPKNIWLTNSFVVDKLNYIPQLLPKITVFDIKELALTSIDCQTLRLSDLKILTSNGFNKILRFFLHKIIILDTNDEIVPLVDVLELVPNVTYLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTU1</accession>
    <name>A0A914YTU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTU1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3410.t1">
        <property type="protein sequence ID" value="PSU_v2.g3410.t1"/>
        <property type="gene ID" value="PSU_v2.g3410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3410.t1"/>
        </source>
    </evidence>
    <sequence length="469" mass="54599" checksum="7FA2FE6E8A7D1435" modified="2023-02-22" version="1">MPEISVRSFWKNRLMFNQSCAHKQQGFTQKHFIPAFLTQDLCILDYKYIGYSDRPNKNNVEYRTNNGEITYSLTLSYTDLYAYDIFHDIGDEVCQISFDLEPGKQFMRFFCLCTQYLCTLKITQKNPLRFCPYSLEIEIDTSLNYSNIQRTSQYMEADLFFMQDENNDFCYLSWTGKATKYNGFVGITGTPLRLGYEFDPNPKMPWFCIFTLYQKREIDSLKSWFYSNDTWELRKTFIDTIIDHSNLINDVYPIGANCTLEGPLSHPFYSSKYKSNSSMFPCYKYFEIDTLSPVYPIMGLNVIPINIVAKGKDCYYYTVKKDEKHFQVCRFLFGTPPIMTFVACPENAKYNKTEVQRIKNIVRACPSMEAGETQWKYVSTKNGICGQFLRGIKLENGKYVPEEIEFKEVTKSDFKMTGMTEKRVEHGCGFNATQTLTLCTCYSALGGCDDLFTAGRVHLLRLINFFVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUJ0</accession>
    <name>A0A914YUJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUJ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3336.t1">
        <property type="protein sequence ID" value="PSU_v2.g3336.t1"/>
        <property type="gene ID" value="PSU_v2.g3336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3336.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11296" checksum="33FCF6CC2078D94F" modified="2023-02-22" version="1">MASNPPSSSRKRKISNAVDISDDEDTDGPKPTFSFKQHCEFEKFAIKATSKTEASKLPSKRSAETLKEMNNRLKTKMYIKEAEKLMDNIFVEKSSKMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVD7</accession>
    <name>A0A914YVD7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YVD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3942.t1">
        <property type="protein sequence ID" value="PSU_v2.g3942.t1"/>
        <property type="gene ID" value="PSU_v2.g3942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3942.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34988" checksum="895ACAD12AB3B686" modified="2023-02-22" version="1">MDDGITFTGSKNKNIRYYTMPKNPNLVNDFENDTKQDNIWEEESFGKMKKMMSMINKVKSGFCDLVLNDDENLEKLKAENFDLGISELFESCGFGVFKKLGLKKYITTFGSSVFPSSASLLGIKLHPSYLPGLMSTSTDDMSFFERIANFVFYFVENWWIKSMFTNGVQKVVQKQFPDFIMDDAIADSAFYFVNSDEHVDYPQPITHKIIYMAGLNKIQAQPLEKKYTDIFDSAKKGVIFFSFGSVVQSSFMKAEMKTAFLEAFSEFPEINFLWKYEIDEHEIAKGYKNVFTGKWLPQNDILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWA0</accession>
    <name>A0A914YWA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3935.t1">
        <property type="protein sequence ID" value="PSU_v2.g3935.t1"/>
        <property type="gene ID" value="PSU_v2.g3935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3935.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="8994" checksum="07D5B2A099744CFD" modified="2023-02-22" version="1">MTDPAAIAGILSKCLKINVTFKGGNFCAHCDCVDSLITLLKNSSIKMTLLCFDITIFNKGNNKFAITNNGTFIGNIYAVKNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWM7</accession>
    <name>A0A914YWM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g451.t1">
        <property type="protein sequence ID" value="PSU_v2.g451.t1"/>
        <property type="gene ID" value="PSU_v2.g451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g451.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27805" checksum="4E15D1D4975DDE68" modified="2023-02-22" version="1">MNPDFGGDVDQDLLELWESDTSLNSINSFNDSINDYNSDNIDANITFSAPQSDDQLCAAFQENYLSFIEPPPPPTLILPLSDHLSLRSSSRNSKKVSFSSSSESSLSFDYSSEESFVPSTPPPKQRPKRSTRAKSTPPIKKASSPREFCSPRGRGRPKKDDDDVDDDKLIHKRKYARAYREQHQQAVKNYQLCAMDFYNTLVASGINVKQKFPQHSKIIQKLIEKMPVTKSTANAKASKKCSRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWS6</accession>
    <name>A0A914YWS6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4414.t1">
        <property type="protein sequence ID" value="PSU_v2.g4414.t1"/>
        <property type="gene ID" value="PSU_v2.g4414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000009">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="43"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4414.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40019" checksum="887C083795B69971" modified="2023-02-22" version="1">MAPHKKDEGNEKATPVVEAPIPGGTKTNSCASTIHLNLPVKKVVVHPLVLLSVVDHFNRVSKTQNVKRVVGVLLGSMKPDKTLDIANSFAVPFDEDDKDKKTWFLDMDYLESMYGMFYKVAAKEKIVGWYHTGPKLSKNDIAINEQLKRFTPNPVLVIIEAEPKDLGLPTEAYIEVQEVHDDGTPPIKTYEHVPSEIGAEEAEEVGVEHLLRDIKDQTAGTLSQRVTDQLMGLRGLHTQLRDIQRYLREVSEGKLPANHSVIYYIQEVLNLLPDVTQPEFVEAHNVQTNDQLMCVYLGSLVRTVIALHNLIDNKLALQKSEKDREDAESDKKKATTNEKDATTISTPVKTEEKTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX68</accession>
    <name>A0A914YX68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2682.t1">
        <property type="protein sequence ID" value="PSU_v2.g2682.t1"/>
        <property type="gene ID" value="PSU_v2.g2682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2682.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11695" checksum="1C2B174ED89E2C6F" modified="2023-02-22" version="1">MELYALYEVGVVRVEVKTVNVNSEVFKRNFLGAQPPIMIEEEKGMTYSDNREIEGRIFHLAKEFRVALFEKDLLVEKSIQNIYRNFKVFLRAKVDHDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXL0</accession>
    <name>A0A914YXL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4386.t1">
        <property type="protein sequence ID" value="PSU_v2.g4386.t1"/>
        <property type="gene ID" value="PSU_v2.g4386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028092">
        <property type="entry name" value="RD3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14473">
        <property type="entry name" value="RD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4386.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13720" checksum="BCF02BCE172589C2" modified="2023-02-22" version="1">MDWKLKAKKHLSFKESSEIESLCQKLKPYEWKEVITTWRDRLAECKNRDEIITSYRDIASEIINARIERELQMIKEAEEPPQVDEGGITLKILDRIQDFSKLQQAEISRSQNYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXW9</accession>
    <name>A0A914YXW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXW9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4946.t1">
        <property type="protein sequence ID" value="PSU_v2.g4946.t1"/>
        <property type="gene ID" value="PSU_v2.g4946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4946.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8965" checksum="6FEF0B8B9EA22B75" modified="2023-02-22" version="1">MSNDSIGIQFYSNYTTSEWEPQFISSIDVPQHDETFFYPLKDNTVLVSFDLLLVHYKLMKFKEMGNVSSRLQLCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYA1</accession>
    <name>A0A914YYA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYA1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4929.t1">
        <property type="protein sequence ID" value="PSU_v2.g4929.t1"/>
        <property type="gene ID" value="PSU_v2.g4929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4929.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="21891" checksum="B3B5952C9C494156" modified="2023-02-22" version="1">MVALHAGVMYCTEITDALWRRYLSQHPENLIEEDSALISFARTQSVRRTRRISGESSGGPGPLSGSLQPNHNGSHQRLSRFLSHHTGSFRLHRGKQSSSRSLSKQQSGPSRSQSPGESHSSGGPLSAPPTGGGIAPTVIQITPSSRPSSRAGFHTQLSSIDSNPQSPTTAITSSEGGGIAHRGSAKAATAFRSIKSSSKGSASDSPVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYI8</accession>
    <name>A0A914YYI8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">legumain</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YYI8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5163.t1">
        <property type="protein sequence ID" value="PSU_v2.g5163.t1"/>
        <property type="gene ID" value="PSU_v2.g5163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037633839" description="legumain" evidence="9">
        <location>
            <begin position="18"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Legumain prodomain" evidence="10">
        <location>
            <begin position="339"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5163.t1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50176" checksum="F05C2801A8564C57" modified="2023-02-22" version="1">MRLSLLVLFFVFGFSACRPNNDDSKLENIWAVLIAGSNGWYNYRHQSDISHAYHILLKHGVLPEKIIVLMYDDIAHNPQNPFMGKIFNKPHGNDVYEGVKIDYRGENVNSEVFLNVLKGDAEGNAGKGTARVLKSKPNENVFIYYADHGGTDVLGMPEGLLSRKDLNEALYHMYENNMYKKLLFYLEACESGSMFEGLSPKMNIYAITASRHNESSWATFCDNDMNLPCLGDEFSVNWMHNTEFHDILSETVGVQVDDVVTTTKKSHVCQFGNTVVRNDMVSDYQGKEAQLVPPQNIELESVFFDEVQSSAIDSRQVPLVMAERTLRRLGASPELVASKMTRYIEKRAEMTEFIHQTAQTVAPQSGLIKHVMTKIPKRITQLDCHDEAIKAFDRYCAPFDRNPFAFKLSAAIANLCEIIRDSEPILAHFNKECSEGPIFYDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYN9</accession>
    <name>A0A914YYN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYN9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5069.t1">
        <property type="protein sequence ID" value="PSU_v2.g5069.t1"/>
        <property type="gene ID" value="PSU_v2.g5069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="46"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5069.t1"/>
        </source>
    </evidence>
    <sequence length="398" mass="43703" checksum="76F9894A21605229" modified="2023-02-22" version="1">MLFLKSKFAIQFERDSIGSPSKKSRSSPPMQSGTGNGLERITPPEIGSDVIDNLMDMEARVNLEMSNRYRNSVITSNGNVMGHQGAETSTPLSQNNSEGLSAFSQPKQGTMQCTTDDLNEISRTTLLLMVEWAKQLPPFPDLTMEDKIILLKNYAPQHLILMPAFRSPDTTKVCLFNNTSMSQDQTNELNGFAAFKTSNITPRVLDEIVWPMRQLQMREQEFVCLKALAFLHPEAKGLSTTSQSLIRDARNKVLKALYSFILAQNPEDAPTRYGNILLLAPALKALTQLLIENISLTRFFGLNEVDSLLSEFILDDPSDQTAAPSSLKERLTASSFAPSSSNSTTTVPSTSTPGLDSRRNMPVSTSMHQLLTGNLLQPSTSGQSSTSQGGQDTVMTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ26</accession>
    <name>A0A914YZ26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5200.t1">
        <property type="protein sequence ID" value="PSU_v2.g5200.t1"/>
        <property type="gene ID" value="PSU_v2.g5200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF548">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5200.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30609" checksum="58540BCB6CC41342" modified="2023-02-22" version="1">MYKNIFRVGVKTGMRLASSIVAASNFATEVAVEGQGPAQYPSWRISPNLLEVDYTKPLGKGSSATIYGAFMNCKAPLANSNDSEQFNNEVKSMTILGWHPNICPFLGWSMSRDRPCLIFESIPNDLLRYVKGFRNLGFPATKDILLITWQIANGMAHIAQHKLVHRDLACRNVLLTEDLRVKITDFGLCCDCDHSYTYTGSISKRLPIKWLAPEALLDRLFSEKSDVWSFGILIYEILTCGIVPYATMSNEEMLEFLRDGKRLEAPDGSPEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2B4</accession>
    <name>A0A914Z2B4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2B4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4391.t1">
        <property type="protein sequence ID" value="PSU_v2.g4391.t1"/>
        <property type="gene ID" value="PSU_v2.g4391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037782695" evidence="3">
        <location>
            <begin position="24"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4391.t1"/>
        </source>
    </evidence>
    <sequence length="489" mass="51950" checksum="ADAB0B703FADCE42" modified="2023-02-22" version="1">MVASNRFSLLLLFVVVAFATIYGYPAATFKHHQEGHVLSTDGPHRVTTVDDESLIVKAAKGVKDTIIEKKEEVKEVAANTLGWIFQKLHHGIDGVHHLKNVTEEKAIEAKDAVVDTAVNIKNKTVEKAEDVKDAVVDAGEKVKEGAEVAKDVAVGGAAYVANKTAHGVEKAIDKAEDVKEGIAEAASLAKNATIEKVAEGMVAVEEFQENAEEKKENAKEDAAKAAERMKEEAHKIAETPEGQAVKAGAEKVKEGAEVAKDVVVGGAAYVADKTAQGVEKVIEKAEDIKDAVAEKKDEIKEDIADAANNAKEFKENAKEDAAKAAERMKAKAQKLVETPEVKAVKDNVEAGAQKVKEGAENAKDAVVDTAVNIKNKTAEKAEDVKEAVVDAGEKVKEGAEDAKDVVVGGAAYVANKTAHGVEKAVEKAEDIKDAAIEKKDEIKEGIADAANNAKENKEAAKEDAAKSGERMKAKASRLFGGENVDENVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z346</accession>
    <name>A0A914Z346_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z346"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6316.t1">
        <property type="protein sequence ID" value="PSU_v2.g6316.t1"/>
        <property type="gene ID" value="PSU_v2.g6316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6316.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14579" checksum="C6F355CFC7311D20" modified="2023-02-22" version="1">MAVTPKNFKWSNSNWGKMIPFICEVPRFPKAFCEPGWILHMKSRSCLYLNKIVSNFPTAAMKCRELGSNVASINDETENELALKMINKAGSNEQVWIGLRWDAARSNIADIPGKNPYETFTFLVQIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3T7</accession>
    <name>A0A914Z3T7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z3T7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6673.t1">
        <property type="protein sequence ID" value="PSU_v2.g6673.t1"/>
        <property type="gene ID" value="PSU_v2.g6673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="9">
        <location>
            <begin position="301"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="458"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6673.t1"/>
        </source>
    </evidence>
    <sequence length="927" mass="104765" checksum="4C432F27E5679927" modified="2023-02-22" version="1">MTNVNKVWPPQAFDGQVRFDVWEMQLEMYMKVQSITDEADKAIALLQHIGLPMLQKLIDWANPKKPFNMKYQELITLLKNHCAPATNIFAQRVRLFNERQLQGQSVQDYISHMSQLLGQCNMSTMDPQQYGILAILRGLESDELRQFLMNPSNKLTDVETTRSLAVSFEQSKIAAREIKSRDDKSRAVGMNVVGKGYSCSYCGGNHYKGKEKCPAKGATCNKCGKKDHFAKVCRSKSASDQRSGNQQSRFSPRRQNIVEDVSEDEVEHLNGLYGILKVTSDPDVDIPPPIMLEAKLNGIQVNFQHDSGAATTVINERTWKRIGAPAVEETTVKLRSYNGNIAVLGKSKVMVEIENKAEALWVIVVKEGEALLGRNWIRALNLKVEDQLHQACHQVETTDRLKQILEKYDSVFKNELGSGKLKVALKLTDGANPKFVKARNLPYAMRERVGKKLDALVEAGIYTKVQHSDWGTPLCVVLKPNGDIRLCGDYKATLNPVLDVAQYPLPRVEDLFHEMNGAAYFSKLDLFDAYHQIELDDESKKLTTLTTHQGLYQCNRLPAGIASAVALFQEKMEQTFQGIPGMVKFVDDLNVTGGDINENLDRLEAVLERCKEKDLRLKKEKCEFLLKKMEFLGHEIDGSGVRPSPKKLAAFTNMPPPENVKQLEAFIGFVNYYGRFVKDFATLASPLNDLRKKDAKWEWNKVHQQAFEDIKAILLKGDLLTHYDPSEEIILATDASEYGIGAVIYHRYSDGREKVISNASRKLTAAERNYAQIEKEALGIIYGVKKFETYLLGRHFTLLTDHQPLLRIFGPKAGDNAIAMKRLARWAIILMNFDYGIEYRKTEDFANADALSRLPDPSEFVSAEMQDDEDDFEQLFAIEEEQSPLNLDRIVEATAEDELLKKSRIFAFQRKAGHSRKTAIGSFKSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4T9</accession>
    <name>A0A914Z4T9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Activin types I and II receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4T9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6912.t1">
        <property type="protein sequence ID" value="PSU_v2.g6912.t1"/>
        <property type="gene ID" value="PSU_v2.g6912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037479850" evidence="2">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Activin types I and II receptor" evidence="3">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6912.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17257" checksum="4337D00F60CFF35F" modified="2023-02-22" version="1">MKLLLFSFYFIYLFSTINCLKCNSSKNVSEAIVTCSNPFCYKLLIIDFGIGNGVKYFEIEGCGAEIEESAILKPFNVTCKDGIQSGNKTVFNTTFNGTLYCCKTDLCNAEIPGLILPSTITPQNPSTKNPLPNNGIIVSHPTFFVVVFGSIISSFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z527</accession>
    <name>A0A914Z527_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SLC26A/SulP transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z527"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7072.t1">
        <property type="protein sequence ID" value="PSU_v2.g7072.t1"/>
        <property type="gene ID" value="PSU_v2.g7072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="67"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7072.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19436" checksum="01B9FBA3325F0BDD" modified="2023-02-22" version="1">MNEHHERSNRIKDMQYHDYITSNSQKSIPKVLKSYMQPCSSPSNLFHSIKSFFPIISWIQEYPSKYLIHDIISGIVIAILHIPQGISYAFLSKVNPVNGLYASFFAPLIYLFFATSKHMSVGSFAVIALMTGAATYHWCYFDSFLCIFSDPLVGGIFYLGFCACSRSQFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5S7</accession>
    <name>A0A914Z5S7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5S7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7694.t1">
        <property type="protein sequence ID" value="PSU_v2.g7694.t1"/>
        <property type="gene ID" value="PSU_v2.g7694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7694.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12403" checksum="2598C56BD217F31B" modified="2023-02-22" version="1">MSLGLGWMSAGKHGKLLHNYIIKSLVFDEIPEHLNQFKTYEICQFVINTVCGDSDGFAITEHFTLCSEENWKYLHNVCVEVDFQIRAFHTYINDRLVMLANEIKECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6R5</accession>
    <name>A0A914Z6R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein phosphatase 1 regulatory subunit 16A</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6R5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8378.t1">
        <property type="protein sequence ID" value="PSU_v2.g8378.t1"/>
        <property type="gene ID" value="PSU_v2.g8378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017020">
        <property type="term" value="F:myosin phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF29">
        <property type="entry name" value="LD46604P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8378.t1"/>
        </source>
    </evidence>
    <sequence length="511" mass="57365" checksum="169C2AC855A5CC1C" modified="2023-02-22" version="1">MDHSQLISELPQLEAMAPVERIALAKERRQQQLIRFLDYDRSNPITRPKKQKLEFSPGVALLEATSRGDLHEVERLLKAGSDPNSHNEDGLTPLHQASYKNFKNCAIDDNENLVRILLKYNADVNAKDTELWTPLHAAACCGYIEIVKLLIANGADLLAVNSEGNMPYDLCDVEQTLDVIESEMAHRSITQELIEEKRGEPERQMLSEMKLLRQRGEPLDSRQPNGSTFLHAAAANGYYDVVAFLLRVGVQPDLKDNEGWTSLHAAAHWNQTDIIELLCDYGASVELKTFASETAFDLAEDVGTRAVIQTMQQQDHAKKKKNPFGLRDSRRQSKRKKKYESLQPMPSVTGENPFSARGAIRRQSLRDRSGLTPARLDAQFEQHNLVRTWSGEDVSNNPDDVSHHQGGRDNSKSSPNKRSLKSGAQKTKPMSPDEWVKKLDAENEDDDDMEGQLNRSARGRSGSRKKQKKRIPGGEHELSDMRGQQPVTTGKGPNFGSTQHQEKKVCCCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6U6</accession>
    <name>A0A914Z6U6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6U6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8058.t1">
        <property type="protein sequence ID" value="PSU_v2.g8058.t1"/>
        <property type="gene ID" value="PSU_v2.g8058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8058.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29538" checksum="D91902FB72B62F97" modified="2023-02-22" version="1">MSDEDLEDELGIRPGAPIDSSKAVYIIDHMLGEGGFGAVFLVHDEKNKDVQYALKVEKKLDTRRHSKLKMEIAILKAVKEFKGKSGKDNDRFMRHFTDIVDRGKKEKYFFLVMQLVGKSLADLKATRPNKIFSIGTGLGVAHQCLEAVEGLHGAGYIHRDLKPANYACGPGTKAHTIYILDFGIARMFQKRNETGGLELKTPRQVVGFKGTVRFASLACHRNLEMGPKDDCESWFYLLLDLVVINGLPWRKESDKKMNWPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z727</accession>
    <name>A0A914Z727_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M13 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z727"/>
    <dbReference type="WBParaSite" id="PSU_v2.g770.t1">
        <property type="protein sequence ID" value="PSU_v2.g770.t1"/>
        <property type="gene ID" value="PSU_v2.g770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="40"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g770.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="24846" checksum="1D3A354804ADFF1D" modified="2023-02-22" version="1">MSNIIGLSVPPITALTTTTQTSTLSPIIDPGTITPTSATIINVAGHELTHAFDSAGVHWGPFGEPINWLDPETQKHFDEMAECVIEEYNNFCPLNSSYTPHCVNGTKTQGENIADNGGIHAAYRAYRNIIDFKGPDPLLPGTLASQFTHDQLFFLSFAQAWCQTPDSIEKTIASLTEDPHSPSKYRIQGTIQNFPAFRSAFNCPIGSASAPKDHCNVWISDINIPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8G3</accession>
    <name>A0A914Z8G3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8G3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8193.t1">
        <property type="protein sequence ID" value="PSU_v2.g8193.t1"/>
        <property type="gene ID" value="PSU_v2.g8193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8193.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11153" checksum="A2ABE4ADA6791AE8" modified="2023-02-22" version="1">MSVNKATVGAITFSGVTLLACLFAISSIYSDVQSIWSELDAEMDGFKVLADDLWRDMVQMGAGTPSNRIRRESYGGYGASGSNTGGYGGGPSGPGGPGGSGQPTLPGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8I6</accession>
    <name>A0A914Z8I6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z8I6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6560.t1">
        <property type="protein sequence ID" value="PSU_v2.g6560.t1"/>
        <property type="gene ID" value="PSU_v2.g6560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007172">
        <property type="term" value="P:signal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036137">
        <property type="entry name" value="Focal_adhe_kin_target_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005189">
        <property type="entry name" value="Focal_adhesion_kin_target_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03623">
        <property type="entry name" value="Focal_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68993">
        <property type="entry name" value="FAT domain of focal adhesion kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="14"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6560.t1"/>
        </source>
    </evidence>
    <sequence length="577" mass="65721" checksum="49A5EF89B40420DA" modified="2023-02-22" version="1">MISESEFHLDRSSVRLEELIGDGLFGNVYRGSYVDVRLKRHSVAVKVCRVDNDSQDLHTSNKYLLEEAYTMQQFRHPHIIKLLGICSGPSISSSDESESDSGTVSTNNNNNNNIPAFGVWMVMELAPFGEMRQYLQREKSIIDLSVQILFAKQIASAVTYLHSRAFVHRDIAARNVLVTNSRCVKLSDFGMSKLLAEEEVYTSSSGKLPIKWMAPESLNFRKFTTQSDVYSLGVCIWEILMHGIKPWQGIRNHEVIKKIEVGEILQRPSECPLAVYDMLRAMWVIDEYLRITAIETTHFLEHLLEEIDDGKNFCELSVPDFHTLRKKIDALPKSNATTNGRKKSVPILNVDASEVPFSTLWRTMESQRQQCEEDEKWLEGEVEDEKSNNNVPSTSSFTTKVSPVEDLNIISSEQQKSKRSPPPPLPEDIELDRASDSIHEAVLRVVQAVTHLTKTYSTQMTNNEFVEKIKKITNELSQLFSESVKDIQKLGNDDRKKVKMVEALLGADLRNMTKAMTHVVDENEKLQCDYYRRHVLKTAHMLAVNCKNYLDTVDEARIRCGIARLCPRSPNLTPSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8N3</accession>
    <name>A0A914Z8N3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8N3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8268.t1">
        <property type="protein sequence ID" value="PSU_v2.g8268.t1"/>
        <property type="gene ID" value="PSU_v2.g8268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8268.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="21287" checksum="A39E4F54431E8A76" modified="2023-02-22" version="1">MGYNDITAGLVSLQSHLTNLRPNHKLSVILITYNDDYFDIINAIPEAKKIPGNIIIVAVNTIAGNLYYLSGTVIQTDKYFNWNTAAQINAAICQGGVSPSPLPTTPSPSPTSTVTGPTRHGVSIYTLQTVTPQSTPQSSVPSSPPTGSSSSPTTSVVTQTSVSTSPTSTPAPGSYYPCQNWITVLADNSNKLSAAQFQVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z957</accession>
    <name>A0A914Z957_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GB1/RHD3-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z957"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8350.t1">
        <property type="protein sequence ID" value="PSU_v2.g8350.t1"/>
        <property type="gene ID" value="PSU_v2.g8350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003207">
        <property type="entry name" value="ATLastiN (Endoplasmic reticulum GTPase) related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.420:FF:000001">
        <property type="entry name" value="Atlastin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="13">
        <location>
            <begin position="38"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8350.t1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59677" checksum="D527EF887FB68E40" modified="2023-02-22" version="1">MTESPGPVRILSLNEEDHSHILDENALAELLLDQRYADKKVSLISVAGAFRKGKSFILNFFLRYLTWREKGDESTDWLTSADKLEGFSWRGGADRDTNGMLIWSRPFLIKDRNNEDVVVLLMDTQGAFDTLSTVKDCATIFALSTMLSSVQIYNISQNIQEDDLQHLQLFTEYGKLALEECKGKPFQQLLFLVRDWSYPYDADYGFLGGDRILSKRLEVHEKMHPELRQLREQIRTSFDKISCFLMPHPGLKVAQNPVFRGELEDIEDDFKSNLKTLIPRLLDPNNVTIKSINGQHVTCRELLEYFKIYITIFHGEDMPEPKSMLQATSEANNLAAVSSAKALYVRQMEDICGGDTPYMNTEALEKENSRCSNDAIQQFKNTRKMGGVEMSLKYLEKLDEEMAEQYKYFARQNNSKNLFKSMRTPAVLVLLMIVDYFFQEVFQFIGLDSIAGIFTSICFLVTIALISWCYVRYSGNGREIGTAIDGAVNWTWENLLQQAVLPASQVGFQIAANATANASKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9I6</accession>
    <name>A0A914Z9I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9I6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8580.t1">
        <property type="protein sequence ID" value="PSU_v2.g8580.t1"/>
        <property type="gene ID" value="PSU_v2.g8580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8580.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16465" checksum="88057EF4BA5F4486" modified="2023-02-22" version="1">MEETRKKLQNGIKIPSGIGGDEIFKFVGQTFKTSKSPSLTFLCTYINGTTMKFQINFDMKQSKLISKTITLVSAAQKMKQLNETWTNLTKPGGKISISLKNVNPGFQLSVNDVVITKFINDKTIKSVNLVTYGGAWTMNAASIIGKTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9S1</accession>
    <name>A0A914Z9S1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9S1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9073.t1">
        <property type="protein sequence ID" value="PSU_v2.g9073.t1"/>
        <property type="gene ID" value="PSU_v2.g9073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9073.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16047" checksum="BAF9650EB1BA2AA1" modified="2023-02-22" version="1">MIIFFLENDNCKVNGWQTVCKSKDPNAICTDKVKGYNCTCSDDYTGKDCETSIIVWKVIQDLGGGEEDIINLLEEVVQSPGLIKDIMPFILGQQSLANQSAMSWDYEDLFVWAAYEETELDIKYFLELDIYKWYDITLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA28</accession>
    <name>A0A914ZA28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8779.t1">
        <property type="protein sequence ID" value="PSU_v2.g8779.t1"/>
        <property type="gene ID" value="PSU_v2.g8779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8779.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="24372" checksum="79E2B37F6B8E78AB" modified="2023-02-22" version="1">MDQPDFQSNFYLVYPNEKHPNFESTVIERSRSIYYFSKGSVIRFFILIFATIFPFYLFTKILKKFQYATVESEVHLYKLSHRINQFEPRILKYKQALNKLDAEEIFYKKKIAIMARDLGFDIPEWYWDPHYWDEIREHRKKHIKIHKEFLQVMAGKIQPPQGWYPEYLRTDLFPDRKEGDEEVTKKSKKIIDKTQINTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA36</accession>
    <name>A0A914ZA36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7103.t1">
        <property type="protein sequence ID" value="PSU_v2.g7103.t1"/>
        <property type="gene ID" value="PSU_v2.g7103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7103.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="31913" checksum="392B174BCB634170" modified="2023-02-22" version="1">MSGDWAWIDGSEFNFSHWDSSEPQNQSDTICGALSLAGGKWSAQDCFKVKPYICEFFIKENATTTTINTTPKTTTTKTTGTPSTTSSTTKKPSTTDKPVTTAKTTTSGTSTSPEDSTTTIYATPTTETSTEGSTTTSATPTTSTTEASTEEPGTSTTTGVNTSPEDSTTTIATSTTSESTDPSGTPMTAAPTTNSPTETPGTFSTSLSDSTTSDTTEPSQTPVTDTTEPSQTPVTDTTEPSETPVTDTTEPSQTPVTESTDSPATVTDDSSESPDASSTDGSTESAETSPPTFPHSPETGSSASIETPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBB7</accession>
    <name>A0A914ZBB7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9215.t1">
        <property type="protein sequence ID" value="PSU_v2.g9215.t1"/>
        <property type="gene ID" value="PSU_v2.g9215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07996">
        <property type="entry name" value="WGR_MMR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035242">
        <property type="entry name" value="DUF5329"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050458">
        <property type="entry name" value="LolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049809">
        <property type="entry name" value="YehF/YfeS-like_WGR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30634">
        <property type="entry name" value="OUTER MEMBRANE LOLAB LIPOPROTEIN INSERTION APPARATUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30634:SF13">
        <property type="entry name" value="PROTEIN YEHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17263">
        <property type="entry name" value="DUF5329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9215.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20717" checksum="798F7CCA2E741272" modified="2023-02-22" version="1">MTLPVYAKLTAHEEARINAMLEGLAQKKDLIFVRNGDEHTCDEAVSHLRLKLGNTRNRIDTAEQFIDKTKEFDNEEQCLKEASKLIAAKMKKGYQEAPNFNFMDRYYFDDEEIGLHLKTSHPNFQCHFTDPLYMCCWDEESPFGSDEGADALNELENSLRKKPDLDCADFPQMLIELCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDP0</accession>
    <name>A0A914ZDP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDP0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8385.t1">
        <property type="protein sequence ID" value="PSU_v2.g8385.t1"/>
        <property type="gene ID" value="PSU_v2.g8385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8385.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13595" checksum="AAEF0C26E5F3F967" modified="2023-02-22" version="1">MTDVEHSHSTKLNGILNVKHAEINIKQPHDTTTKVTFQGGSGIENDDDENEFNNQPSAFIRGTSRDSQYLGGVGHRLSTVIRRSLRLGPKRSVTTGSRSSSSRFPPHVTVEEKFLISYKDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFB2</accession>
    <name>A0A914ZFB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Decapping nuclease</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZFB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8965.t1">
        <property type="protein sequence ID" value="PSU_v2.g8965.t1"/>
        <property type="gene ID" value="PSU_v2.g8965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8965.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="32407" checksum="E6C992AAC3038353" modified="2023-02-22" version="1">MEYFGISNKDPVNDPFIKDFSQFPFIFEKDLFNTIIIEEKELALDNTNYHNCSVPVLFEHRNNVALKNIWDGIKNGDIVTNRGAKRSLAADKKNQKIEQKVVNVNGNEKWIYLVTRGQKKKLSVAKFNSGFYAEMNVFQCPFNDYTIYRYTKAYNRELHCFEHYTSEIDGFIKMDGNYAPVEFKSIRSFRGTTVDNFERSWNIDAVIQCRLAGINNVIIGYRNGNEMKLQRFHIDEFEINVKNSVQCSLLRMNRNMKEFVKNKKVLDAHYPRGDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZG31</accession>
    <name>A0A914ZG31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZG31"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9241.t1">
        <property type="protein sequence ID" value="PSU_v2.g9241.t1"/>
        <property type="gene ID" value="PSU_v2.g9241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9241.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14331" checksum="78F61098E9F7DE7D" modified="2023-02-22" version="1">MEAEKSSAENYIPKKATQQEEFLQKYPEFDGRGLLIAVMDFGVDISSPELQKTSEGLPKIIDSFNFNKDVKIDTSVIREVDTDNILIGLSGKKLKIPSFWKNPSGKWHLGIFLSEGDTEVRFEKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHV9</accession>
    <name>A0A914ZHV9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S13</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZHV9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9888.t1">
        <property type="protein sequence ID" value="PSU_v2.g9888.t1"/>
        <property type="gene ID" value="PSU_v2.g9888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9888.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17340" checksum="8140B8B4945FD6E4" modified="2023-02-22" version="1">MGRMHNPGKGISRSCLPYRRSVPSWLKLSATDVEEQIVKLARKGLRPSQIGVILRDSHGVAQVRRVTSSKIVRILKAKGMAPELPEDLYHLIKKAVNVRKHLERSRKDTDSKYRLILIESRIHRLARYYKTKRQLPPTWKYDSSTASALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSB5</accession>
    <name>A0A914XSB5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM GPCR serpentine receptor class x (Srx) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSB5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10165.t1">
        <property type="protein sequence ID" value="PSU_v2.g10165.t1"/>
        <property type="gene ID" value="PSU_v2.g10165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718:SF11">
        <property type="entry name" value="7TM GPCR SERPENTINE RECEPTOR CLASS X (SRX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10165.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20091" checksum="71840CD298920477" modified="2023-02-22" version="1">MLLQFVTSMNRIFLYYKVYSFAYLRTDFNIADFAIDLPINILCSLIPVICYWRIYIFVRASNNQILTSLSEKDAASRKQKETKYALQFAACTGFCIFAWISFRIIPLLVPINLVEIFAIVTCLELAHCISNSLVFFLFNPEVRRKFLIPTNQSYESTTHYNNGGNVASTATSKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT48</accession>
    <name>A0A914XT48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT48"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1014.t1">
        <property type="protein sequence ID" value="PSU_v2.g1014.t1"/>
        <property type="gene ID" value="PSU_v2.g1014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1014.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="13700" checksum="36430A34214C5A91" modified="2023-02-22" version="1">MTDCKADIVFKDSAGKSVQESVSFMFFDTSRSGYDVEIVRSGDDPSLVTLDLGVEKLWDRIFTLGVFTVLLIGGAIAVIVAMIRANDTPALAVLPQGCDVPVLLDENLDRLDLTADEKQAIHNALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTP1</accession>
    <name>A0A914XTP1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTP1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10337.t1">
        <property type="protein sequence ID" value="PSU_v2.g10337.t1"/>
        <property type="gene ID" value="PSU_v2.g10337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10337.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38139" checksum="1EEB31C17BAAE257" modified="2023-02-22" version="1">MWFDADIINEEENNIIDDGGGSDCDSGVNDNISDINTISDIEDNLEPVDMEVINYVYNNQQQQLEYHQLHHLHPIIEADDETASIDSGADFSENKLELLDADVCNVEDCNDIDSIIADPTIRVAGIANDWINFDDKNKKYNITYKIEPFISEYGNIFTNKLEYMLHVVIPKLHQHADSDIFAKLKPQRINPNFKGSLERYLSLEVIEQRILHCFYSDYGHCLNDFEMLLFFNTFPKEIYNFEHKDSIGIFFRKLLHRLPHEEIELPPPQYKSSISSSTTSPTITCRRRKRKLSFSSSINDDEATASKKKRALIISTNDLLNRFKAFSPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUC5</accession>
    <name>A0A914XUC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10569.t1">
        <property type="protein sequence ID" value="PSU_v2.g10569.t1"/>
        <property type="gene ID" value="PSU_v2.g10569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF314">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10569.t1"/>
        </source>
    </evidence>
    <sequence length="423" mass="46087" checksum="EE26D30F93AD341F" modified="2023-02-22" version="1">MARVLTGFSDALLQPSTNSMITRWFPPKERTFAIGIITGGRQIGTLLILPTAGFLCEKKQFMGGWPSIFYISAFIVAIILIFWVILSADKPAKHFCVSKKEQSFIQEKIQEENLGKRKERKSVPWKSIATCVPLYAGVAALICHEYPLVIMLQLLPKYMDDVLKISVQMNGIISALPIIVLFVSKTLSSSLASVIGSRKRGRFLLSRTAIVKIFNGIASLGLGICIGIVPLMNGQGHSAGAISLLCLANVFAGMHTPGVQTALLQLAPAYSGIITGIAFGFVAIFSILNKVISNVIVKDGSLSEWTLVFEISAVVAVLPVFFFTIWGSADRQPWASQKHATKNISTVTSESNDTKKPHFTVGGESTLKNSQNDYSIANGIRFTMFLNEVDDLNDVDYDERDTSGSGSLNSNETETTSVEEGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVB2</accession>
    <name>A0A914XVB2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11878.t1">
        <property type="protein sequence ID" value="PSU_v2.g11878.t1"/>
        <property type="gene ID" value="PSU_v2.g11878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF3">
        <property type="entry name" value="MSP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="102"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11878.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21498" checksum="686BAC2BD2425C72" modified="2023-02-22" version="1">MDSQIAAEKVVAATDTDTEIVGRKRRKRKSSKNAGGGGAEFLVERSKIVENVWKKFIQDDAIIIRKKNEEKIGENNKIARETAAKVKDFEWIKKLSKINSSNLDTKFCHRIYCHFVQISSAGGSSTHQLVNSGASRLAFKVKSSNNTEYRLKPVFGFVEAGASAPLEITRLPFKIWKGTENNINPKLPIYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVF1</accession>
    <name>A0A914XVF1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914XVF1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10951.t1">
        <property type="protein sequence ID" value="PSU_v2.g10951.t1"/>
        <property type="gene ID" value="PSU_v2.g10951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000283">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10951.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33520" checksum="3C6FF1DB110FCB51" modified="2023-02-22" version="1">MEVQKNDKYFETVFSDTRLSILNRYRDLFVIGSGAQGLVLGAFDNVANQKVAIKKLTRPFSNVTHAKRAYREFVIMNLVNHRNIIKLLNAYTPQDNVQEFSDIYLVMEYMDANLCQVIQMELDHERMSFLLYQMLCGIHHLHKSGIIHRDLKPSNIVVNLRCQLKILDFGLARTKERETAMLTPYVVTRYYRAPEVILGIGYNANVDVWSIGCIFAELIRGRVLFPGSDHIDQWTKIIEIVGTPNAEFCERLQPTVKNYVENRPYCPPKPWNTVFPSSIFPAVVESRLTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW89</accession>
    <name>A0A914XW89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XW89"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10048.t1">
        <property type="protein sequence ID" value="PSU_v2.g10048.t1"/>
        <property type="gene ID" value="PSU_v2.g10048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008131">
        <property type="entry name" value="PRK10879.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10048.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37856" checksum="83C22A2DD6744BBF" modified="2023-02-22" version="1">MQPGSAALIFAAPEVTRSADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQLLNGLDVVYHAQGEYAYADEIVNSALEKLRKGSRQNLTAPATMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPFFYAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW94</accession>
    <name>A0A914XW94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XW94"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10053.t1">
        <property type="protein sequence ID" value="PSU_v2.g10053.t1"/>
        <property type="gene ID" value="PSU_v2.g10053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF39">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037172405" evidence="9">
        <location>
            <begin position="22"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="34"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10053.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36837" checksum="15D2F6CBBE1B32E1" modified="2023-02-22" version="1">MRIKEIWIGIFFVFFFEIVSAKFPNEIADVPIVNCESDKILIKIRTTASNPSHIYAEDFRDNSGCQSRNMNNIAILHGECGMTSEKLSNPDGIMYRICISVQIHPLFVTESDRSYCAQCVYMDSTVVNDLQQNLAISDALPDELEPQFDETSNPQCSYTIRKGSVDGPEIHFATIGDSVFHVWQCQNAFQESHVFKFADKTLTRFTCQIRLCMKDRKNGCDKITPPKNCKSDGEVVDSDAVGKDQPLPPAKLISEPLKAETVGPPSITPPQHHHHQQQQQTKTIGRSSTNNNNNNKSTVVINGIPAAQRGVTNVKNDNDNNNQKQSSYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWE5</accession>
    <name>A0A914XWE5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914XWE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10854.t1">
        <property type="protein sequence ID" value="PSU_v2.g10854.t1"/>
        <property type="gene ID" value="PSU_v2.g10854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000004">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="299"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10854.t1"/>
        </source>
    </evidence>
    <sequence length="527" mass="60592" checksum="ED3A7D230C38BFD5" modified="2023-02-22" version="1">MATPKEQQQAFDSLIKALTSDPILVAPDYNKPFVVITDASITAIGGTILQKGDDGQLHPISFCSKVLSDAERNYSTIEQELYAIVFTLKYHKHILYGSEIFLQTDHKPLISLITKPSTSTRLNRWLVELQEFNLAEMKHVPGRDNVIADFLSRPPVETQMLAIHGETERNSKRLQMATEEDKTLKMVLKQIKEDWKNVDLTLQPELKPYYYVRKELKYDEEAKVLKKSNRIIVPESLQPELLKILHRSHFGQERMKLMCREILWWPRINSQIEQIASTCIPCNQHRNKLSPGPVHPWPNADGPWQRIHIDFFGEKWNSTWLVVVDSYTKYPIIVKMKSTDSAATIKALQTIFNNFGYCKTIVSDNGPQLVSNEIKEYYASKQIHLMPSPPYHPQSNGLAERMVGTAKKSATKILAANPKMTPEAAIQQFLDDYRATPHKTTKRSPNELMFCTPPTHLLSTFVPRKDTENEPKPRPTKSKLNFAPGDLVWKRAFRKKVKWEAGTVVQRESNYIYVIQDEWGSNSHKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWP9</accession>
    <name>A0A914XWP9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15 16">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A914XWP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11391.t1">
        <property type="protein sequence ID" value="PSU_v2.g11391.t1"/>
        <property type="gene ID" value="PSU_v2.g11391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000003">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000043">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase, platelet type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000064">
        <property type="entry name" value="Phosphofructokinase, platelet b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 15 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="59"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="448"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="15">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="15">
        <location>
            <begin position="448"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="339"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="574"/>
            <end position="578"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="619"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="707"/>
            <end position="710"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11391.t1"/>
        </source>
    </evidence>
    <sequence length="822" mass="90984" checksum="D0E3C14A82ECE280" modified="2023-02-22" version="1">MGEPVESPDGPSHLQDDLAPLLISAEKAKKLKIRQESIIPTAGREGTDIERLLYKGRSMAVFTSGGDSQGMNSAVRSVVRMGIYLGCKVYFIYEGYQGMCDGGENIREADWNLVSDIIQRGGTIIGSARCKDFREKEGRLKACFNLIEKDITNLVCIGGDGSLTGANTFRQEWPSLVKELLQQGKISKEKAEKCGNIQIVGLVGSIDNDFCGTDMTIGTDTALQRIIEAVDAVMATAQSHQRAFVIEVMGRHCGYLGLVAALASEADFCFIPEWPPPTNWREILCAKLHHTRSTGNRLNIIIVAEGAIDREGKPITVEIVRDVIKNTLHYDTRATVLGHVQRGGNPSAFDRLLGCRMGAEAVLALMEMTPESEPCVVSIDGNQMVRVPLMECVARTQAVQKAMDGKEWELAVKLRGRSFQRNLDTYRLLTKLHTPTEKDNLSEGKTFNVAVMNVGAPAGGMNAAVRSFVRMGLYHNCNVYGIHNSFDGLASGLVKKMEWGDVSNWVMHGGSFLGTQKQLPLKNLPKIAEQLKKFKIHALLIIGGFEAYNSVLQLARHREKFEAFRIPMSVIPCTISNNLPGTSLSLGCDTAVNEICHMIDKIKQSATGTKRRVFIIETMGGYCGYLATISALASGADNAYIFEEKFTVDDIKEDVNVITSKMQHGVQRYLIIRGENANRHYTTEFVQQLFAEEGKGEFSTRINVLGHAQQGGNPTPFDRNMGTKLAARTLEYLVTQAKEYVDLEKGENKAMDSDTATLLGLRGRRVVFTPVEELANETDFDHRLPLDQWWLKLRPLLRILAKHNSTYYTEAMDVPAIEGEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWR6</accession>
    <name>A0A914XWR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWR6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12388.t1">
        <property type="protein sequence ID" value="PSU_v2.g12388.t1"/>
        <property type="gene ID" value="PSU_v2.g12388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12388.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10160" checksum="16547052E7556380" modified="2023-02-22" version="1">MPTISNSITYGAKRNRSRAIRVSFLLVAAYIICWLPYNALGLIQFIDPETFSKHANKVYCLHGMMVFNSVVNPYLYGLFGGVCRPKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX06</accession>
    <name>A0A914XX06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein let-4</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX06"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12479.t1">
        <property type="protein sequence ID" value="PSU_v2.g12479.t1"/>
        <property type="gene ID" value="PSU_v2.g12479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037309023" evidence="5">
        <location>
            <begin position="21"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="684"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="552"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12479.t1"/>
        </source>
    </evidence>
    <sequence length="777" mass="86865" checksum="FD701CF8AACF1536" modified="2023-02-22" version="1">MARNFLFLAIFSYIFITIYACPQLISSYCQCVDETDGVLLNCTQIDADQIVQILKTSQAEVGLIKWLILQKTNIPKLNENFFNGLYIKRLDLINNGMSELDDQAFNGLGSTLQELNIQYNNLSHIPVKALSKLNSLLRLDLTHNNLGKLEVEDALPTLTKLYDINLAYNKITDVHKNLFENNKNNLQTINIGHNQMREVPASALRGFRKLMALHLHNNKFAKLPKLSFMNLPVLSLLNLASNRIESIDRQALLNVPSLRYFYLTGNKLATILPYQFNSFEELEMLDLSNNQIQSLPTNAFSNLPKVRQIYLGENHINVIKDHAFANSSTVILILESNQIQEVTANMFDGMIALQQLSLKDNQIKVIDSNAFRNISTLQMIDLSKNQLIDFAPSTFMAQMNMLLIDISQNKLIRTPYSAFSRRVATVLLQENPLVCSEKVHMLQQGLGVYVPNSEDKICAGQKSIDEVIESHKVENPVENVFKTDDSENIPAFNPLQITPKVPAAVETMSKNIHPINIHSIPSQNGGEPATTIIRPVNQNSVPIVPERSAIEENNQNKNLQQSKPDINSTSTKPILPYPDDPDHPDNHPNIYYPLPVPFLKTPPKMHPAYTVTQTLPPSIVIADGSTEADETAKEASENTSETKIEKFEAPTSAVFDETNLINEGERKPYELEDQRAAQKAEQKLPIAILIACVSIVGIVMLAVFVGLCVARQRHNHFVGSSSSSTTARTNAQFSAQMNAVYGTLPHQRAGTLPRLSAQEDIYNWLYGHGGCNAYPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYI6</accession>
    <name>A0A914XYI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12020.t1">
        <property type="protein sequence ID" value="PSU_v2.g12020.t1"/>
        <property type="gene ID" value="PSU_v2.g12020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12020.t1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38667" checksum="01E1518A3BB34057" modified="2023-02-22" version="1">MSLKLVFILFEFPRQQENEKTKTTEVAQFKASQKLLNPNESIDEHTRFMTTYLQWAELYLNALKSPYLLLAQNKWIEFNCDYNAIKRYINTMQEEIHRYYDKSLNSTLSSLSESQSFLQSIVSTYDDEQKPSSNDADIIKSNCKKEKEKFNKRTKFSEKKIIEMLLVMPVDEEFENASEKLIKLMKTSPYDDDEEEENYDSFSSSNVESTEHIVKAMELLKISDDDMSDTSDLHDVSDWKSDNLSCSDREVARNSPEYVIDYNCNDVNDEANISLISDIQKSPAKEYEYELLEISDNDIDSASAEVENNEPKCISDNLSSKDLLKIALNMDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYK7</accession>
    <name>A0A914XYK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10778.t1">
        <property type="protein sequence ID" value="PSU_v2.g10778.t1"/>
        <property type="gene ID" value="PSU_v2.g10778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10778.t1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50383" checksum="DEA45C05E2A34A19" modified="2023-02-22" version="1">MFSSSNGIFPKSLSNLTTLILHSCNILTLNENVFVNLRSLRYLYLTDNFLSTFPKALNAVSGSLEYLNLGHNPNITILKNDGFKIFKNLTSLDAYSTNLERIEDCAFCNFPNLKEVDLSESKKLSYIHENAFGAISNEKPIQIGTFLIGSCNISSLSEKLLDWKNVSIIDILYNPITCNCSMAWLINDFNATTPMYVNKLRTFEWRPYKAELRCTNPPELKGEHLYKLSGDFCLNETAEIKEEEKIYQVCGGDKNDEERDPACVCENENLRCNFVENTNIEIINKTFEIKSILIIIGNITKLNLKKLVPEKQHLIENLHFYHSHISSIENGTFDNFTALKTLDLSENSLTTIDETILTKQLGSNLIELDLNFNILKNISSKTFMHLTKLKVLKLHHNREISNLFTSELFSESLKSLEHLDLSDCNITSLKEDVFVNLRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYT7</accession>
    <name>A0A914XYT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYT7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11696.t1">
        <property type="protein sequence ID" value="PSU_v2.g11696.t1"/>
        <property type="gene ID" value="PSU_v2.g11696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037977852" evidence="1">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11696.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12371" checksum="AB3AAAB316142B95" modified="2023-02-22" version="1">MYKFGVVGLTAILLFLFNSATPSSATTSNPSECGEWSEWSCKCCGGCPTQRCTRICQATSECPTCSGEAKKEDSAPCSSPSETCKFPLPVCCEGQEAYANSEVQPIAKWCRTATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYU6</accession>
    <name>A0A914XYU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYU6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12124.t1">
        <property type="protein sequence ID" value="PSU_v2.g12124.t1"/>
        <property type="gene ID" value="PSU_v2.g12124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12124.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10322" checksum="34A3C39379AFFB6A" modified="2023-02-22" version="1">MLQLNGRLNVCDAKIDVNLLLSHLHSCHLKDLRLVDQTISENDFIKLVSSKTIQKFIFCRNTVINDKEKRSMKMEEILKHLPNVEKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZG9</accession>
    <name>A0A914XZG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RUN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZG9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13351.t1">
        <property type="protein sequence ID" value="PSU_v2.g13351.t1"/>
        <property type="gene ID" value="PSU_v2.g13351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="1">
        <location>
            <begin position="84"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13351.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19946" checksum="7F6C18C9614D4B63" modified="2023-02-22" version="1">MLQLFPRRQISHVEQSTSKIPKIPQRKISECYLERKTRHGSVISIEMSEVPLEGADLRKDQLIKALKREVKRIMDESGIKKRVCLYSNIVSSICVAVENCLLDGLRRRLLGLFGVKTTFALLHCIAKNCGPAANVIKRTTEHGNAEGSRNTYLWIRVALHERALSSIVDHIFNSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZH2</accession>
    <name>A0A914XZH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12364.t1">
        <property type="protein sequence ID" value="PSU_v2.g12364.t1"/>
        <property type="gene ID" value="PSU_v2.g12364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12364.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25745" checksum="BDF94A1ECEAE199A" modified="2023-02-22" version="1">MRQLLSIFPKKALEAVIFCFTNSRGTFYKPGDSIGPITKLIKNLQEESGAKLNFGKNNVFCMDNEGFRFLCAKACRIDYTTATHDDYEDSWKQSRQATFDLVRRIKDEKPFDTRTINFYTELASVTKKWAEWLKHCRMSAERCKRFGTVAHELEKNLIGSNVKDLVQLAEKMKFKYPRHISDLRGLMIILHEEFVERDLDNNVANEIRSFIDRYIFQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0B4</accession>
    <name>A0A914Y0B4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable arginine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y0B4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13644.t1">
        <property type="protein sequence ID" value="PSU_v2.g13644.t1"/>
        <property type="gene ID" value="PSU_v2.g13644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000002">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="13">
        <location>
            <begin position="145"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13644.t1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44799" checksum="394AE5DCE809A4DA" modified="2023-02-22" version="1">MSSNNVYTEEDAAKARLSSYEEQLIKLKKQFELVQQGTPDEETLDHMVDLKAALVTNAKLKYHKNFLQKSIENVENEVKSGTFKKPTDDSQSSAAPAEQKKSDNSGKKGKGNEQPPVKKDKKETKPSVPKINYVVVEDYGDSLMNRLKEIFTEAQKTAYPQVTNFPPIMTEATNPKFGDYQCNSALGLSKKLKEFGVNDSPPQVAKNIANAVQKGEYIKDVEIAGPGFINVHLQPEFLGARIGKLLQNGIQPPKIAKRKALVDFSSPNIAKEMHVGHLHRFPNYLNETPPIGDLQAFYKESKKRFDEDETFKARAYDRVVKLQNHDPEIIKAWKMICDVSRADFGRIYEKLDIKITERGESFYQEYMVKLVKELEEKNILITEEGRKIFFPTGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0L9</accession>
    <name>A0A914Y0L9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y0L9"/>
    <dbReference type="SMR" id="A0A914Y0L9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12759.t1">
        <property type="protein sequence ID" value="PSU_v2.g12759.t1"/>
        <property type="gene ID" value="PSU_v2.g12759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002632">
        <property type="entry name" value="PRK02304.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002633">
        <property type="entry name" value="PRK02304.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="31"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12759.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19859" checksum="AB45F0B5A219480D" modified="2023-02-22" version="1">MTATAQQLEYLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIDLLVERYKNAGITKVVGTEARGFLFGAPVALGLGVGFVPVRKPGKLPRETISETYDLEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVADAAFIINLFDLGGEQRLEKQGITSYSLVPFPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1H0</accession>
    <name>A0A914Y1H0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1H0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14041.t1">
        <property type="protein sequence ID" value="PSU_v2.g14041.t1"/>
        <property type="gene ID" value="PSU_v2.g14041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14041.t1"/>
        </source>
    </evidence>
    <sequence length="504" mass="58270" checksum="2482EDF7064B8783" modified="2023-02-22" version="1">MDCGKIRVSNEKKLGSMFTIPSSNPKWPEIEENTNPGETRSDLKCRVFLTKAQEFLDDLFKKNIFGKVQAYHVVMEFQKRGMPHLHVLLIMEDEVTVKEVDNYISARIPECPADDDKSDGAEQQREYHKLVIKHMLHVCNANSACQVNGKCTKHYKKNFSNCTIIHSHKPADYQRLKPQSAADKNASEIKIDTKNSDENVKINASQDNIDWEDDSIFNELKEKTETENAKEKVKVKSETFEAKVDDDWEDELPFFDELRKDFDEELSHVEYKRLEPPPKDLELNEENKHLFGFTGRKPIRGKADLVVDDSVVVPHNKYLLLKYDCHINVECTIGQTGSPKYTCKYVTKMGDVVCAKLQKVKLNKDGEEVIDFDEGERHLIARIMTGCEAWMRASNCWIIKQSHIVECLQVHLEGGNTKVFQPGYEAEAADKDDKSQLIAFFALCAKDKSAEKYTYREIPQHYRYTNGAWVKRKRATNRFFVRIRHVSPKNSELFALRMLLMKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1K6</accession>
    <name>A0A914Y1K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1K6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11700.t1">
        <property type="protein sequence ID" value="PSU_v2.g11700.t1"/>
        <property type="gene ID" value="PSU_v2.g11700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11700.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14524" checksum="0C783793A8704AF2" modified="2023-02-22" version="1">MKNYLRRFRQYLSESGPHPDDDFDYPGSDLEASRRSDRLAARSGGGGISKKKKSSTIKKKKKSTATGGEGGGDGGDEDGQSSSVFESSEEESSTARLSRRSSVLVDLFALFRRSSSFGRRTSGRYSSRGMYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1U5</accession>
    <name>A0A914Y1U5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1U5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14154.t1">
        <property type="protein sequence ID" value="PSU_v2.g14154.t1"/>
        <property type="gene ID" value="PSU_v2.g14154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14154.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="8326" checksum="12AA50E3E25150A2" modified="2023-02-22" version="1">MAVALAGRGDRAAMQFDQLLHDRQAQAQAAMASGGGAIGLAEAAEQMIEEFGRDAITGIAHGDLPVVAVGPQLQVECGLQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y234</accession>
    <name>A0A914Y234_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y234"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13297.t1">
        <property type="protein sequence ID" value="PSU_v2.g13297.t1"/>
        <property type="gene ID" value="PSU_v2.g13297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13297.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13213" checksum="453B07262964CF27" modified="2023-02-22" version="1">MWRILQHDKPDDFVVATGQFYTVRLFLELSFKEIGKEIVWQGEGVDEIGIEKGTHITRVKVNPKYYRPTEVEELIGDPTKAKTVLGWEPKVTIEELVKEMVESDIKLMKHNPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2S4</accession>
    <name>A0A914Y2S4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H oxidase (H2O2-forming)</fullName>
            <ecNumber evidence="3">1.6.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NADH + O2 + H(+) = H2O2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11264"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1375.t1">
        <property type="protein sequence ID" value="PSU_v2.g1375.t1"/>
        <property type="gene ID" value="PSU_v2.g1375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042335">
        <property type="term" value="P:cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042303">
        <property type="term" value="P:molting cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009886">
        <property type="term" value="P:post-embryonic animal morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09820">
        <property type="entry name" value="dual_peroxidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000195">
        <property type="entry name" value="DUal OXidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000020">
        <property type="entry name" value="Dual oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000004">
        <property type="entry name" value="Dual oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034821">
        <property type="entry name" value="DUOX_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF175">
        <property type="entry name" value="NAD(P)H OXIDASE (H2O2-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1045"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1146"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1182"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1211"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="874"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="1232"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1375.t1"/>
        </source>
    </evidence>
    <sequence length="1520" mass="173908" checksum="642E17CB84AEF8C5" modified="2023-02-22" version="1">MNHKRKKLNKCAFLALDRIHEFQRYDGWFNNLANPQWGSVGSRLHRDAPSNYQDGVYLLPTNLPSARVISDLVFKGQSGIPSQRNLTTMLAFFSQVVAYEIMHSTQNSCPLEMLKIPVPKCDEVFDKECEGKTEIPFSRAKYDKTTGHGLNSPREQVNDRTSWIDASFIYSTQEPWVAELRSWQNGTLAEGPMKGYPPLNNEHIPLNNPAPPQVHRLMNPERLFILGDSRVNENPGLLSFGLVLYRWHNIQAKRLQEIYPDWTDEELFQGARRFVVATLQKIVLYDFIPALLNNTNAVPPYERYKPFMPPGISHSFATTAFRFPHSIVPPALLLRKKKGNNTECEFRTEVGGFPALRLCQNWWNAQDVVQEYSVDEIVLGMASQIAEAEDNIVVEDLRDFIFGPMHFTRLDVVSTSIMRARDNGIPPYNELRKTFSLPPKTFATINPTFTANHPEIIANLSALYNDNIDILDAYVGGMLESNGDGPGELFTEIIRDQFLRLRDSDRFWFENKLNGIFTDEEIQYVFNITLRDIISETTSISPSEIQENVFFWLAGDPCPQPFQVNTTGLESCVPFMRFDHFTGNEVAFIFTCIVLATVPIVCIGIGYFLVQKRKKMGILFDQSEKVKAKLSLAHFAANNIIHPSAETSDIMKINGKEPKFTFPAIEWLNETFCRSVTVTLDVSVPLIKISKRRGGTLRRLDMSQTHVVTITVTKKASRPVHGPFVCISVPKNYDVVLRLQSETHWLQLRTAIANCLAKHKKAFREIEAENDVLLEEAETKDKRQAKLDHFFREAYSKAFNAPSLSDNSTKQFEDVPSEEVLQMKLTKSEFADAMGMRDNDLFVERMFACMAKQESDSVCFQEFLEVLKRFTKGGQKEKFQLVFEMCDRDGNGYVEKSEFCDFIKSLNMAVGVKIDQYTQEDVVESILHNAGIKPEQKSLSYKDFEAIFNEVNHPRRPLGVHFRKAQLKVNLEETDSLNSFAVTAEQSNCFEANWMSLIFSYLETYRQHIAIIFMFIAINLILFMERFWHYRFETEHRDLRRVMGYGISITRGAAAAISFNMAIVLLTVCRNVMTILRETPLGEYIPFDAAINFHKIVAITAGFWATIHTVGHCINFYNVATQSQEGLACLFQEAVFSSNFLPSISYWFFGTITGITGILLVVVMSIIYVFAMPAILKRAYHAFRITHLLNILLYALTILHGLPKLLSAPTFWYYVTAPIIIFVLDRIIGMRQQYKQLQVTEAAILPSDIIYIQFKRPYFFKFRSGQWVRVSCPAFSCTFNEHHAFSLASAPQSPVLELYIKAVGPWTWKLRNEIIESQSSCLPYPVINLNGPFGDGNQEWTNYEVVVMVGGGIGVTPYASTLSDLANEVAAENHSNIRCRKVYFIWICPTHKNFEWFVEVLKKVEQADTRNIIETHIFVTQFFHKFDLRTTMLYICEQHFRGLTNSNNSSMFTGLKAQNHFGRPNFDVFFKYLQSKHQSINDIGVFSCGPAAVNKQIRKACTEANRVRNAPSFVHRFETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2T7</accession>
    <name>A0A914Y2T7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2T7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13553.t1">
        <property type="protein sequence ID" value="PSU_v2.g13553.t1"/>
        <property type="gene ID" value="PSU_v2.g13553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF16">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13553.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24682" checksum="6307DF6749C0216A" modified="2023-02-22" version="1">MEKRISFILALFEDELKQFRIEELCGRYSGFNDIPSIYWQVSTCLIAFGCLLTTTLTLILIPSCCFKHIVSKNSAIIIGLLQAVAAVCVSCGCLLYPLGWDNQEVRDACGPLSGRYFLGECQVGWAYICMLIGSALLLTCGALSICGGREPDADPQFTSYRNRFRPTAIGQPPTRYSFDAETLIDHNLRRHSLATSTGRRTSTQRIFRPLIPTSSHLPQCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2Y3</accession>
    <name>A0A914Y2Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2Y3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13808.t1">
        <property type="protein sequence ID" value="PSU_v2.g13808.t1"/>
        <property type="gene ID" value="PSU_v2.g13808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13808.t1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43812" checksum="13A595C71DEB0B18" modified="2023-02-22" version="1">MNPPEGYTFKILSLFADSKVLIVANDEKQYIQSHLPFYFNTTNLTLACTANYENALFTDKTFLARISIVNLKRSESNDYCTFNETSSTWSSPPNKYTTKVKCQKYFTIVPGHQLYADVTSLETTGVTDIETFIDVLRYYVDEDLLYPVPFAHTGLYAFSPFNNNDTKRNITFEYTSDESLIYQGFSITFKDFVFPDFDERYSASIQITSDKHVLINTDGIYKRIWEGRHQKALILSNRNTTLIFKSSSKSMGYISVPIGSLRLWATSFNDEPLYIFKSDEILGNQVLTIELSEELKAKNETLEMFYETSNAKHFLHCLTFYKEETMETIIKINLINSDFVINSGITIYKYAECEKDLTKLFVRGKTITQTHWIHGKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y301</accession>
    <name>A0A914Y301_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y301"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13826.t1">
        <property type="protein sequence ID" value="PSU_v2.g13826.t1"/>
        <property type="gene ID" value="PSU_v2.g13826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF1">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13826.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="29399" checksum="A460022456A602D3" modified="2023-02-22" version="1">MLTIFYNSAPFIPCTQIFEYIVSILDSYRRVLIIWDKIFGTFEPERDAEKPVYGLITNVKSFDALWLQFFEFKAIGWDKGWMKNKKGEDRFPGIWNKIKCVVAPPGWFRGLPTKQFFWWRCMEDPGKGIPKIEKDVVRYSQPLNLYETLYVVVLFLTSFGCSTEFYPHRNEMSWQLFIAYSAYLLSNIQMVGYYLDKRPVAIPLDILRLTVTCVYCILQSNITILAFSLFSLFYVIYFLRNPTKSVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3C6</accession>
    <name>A0A914Y3C6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3C6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12269.t1">
        <property type="protein sequence ID" value="PSU_v2.g12269.t1"/>
        <property type="gene ID" value="PSU_v2.g12269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="5">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="4">
        <location>
            <begin position="445"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12269.t1"/>
        </source>
    </evidence>
    <sequence length="728" mass="82649" checksum="913FDE6286C829FA" modified="2023-02-22" version="1">MELVCKALEFDDSSKATAVNVRDAACYICWAFARGFGKDTLDYEILKTLAFKLVSTALFDRSVNVRRAAGAAFQENVGRNIFSKETEKFPEGIVLSTMIDYQAVARIELCYSSLCLEVANFGKYVHPLMESLLNVFSGHWDEKIRILAASAIQGLVKFDALYSVNILLPKFYEKLSSTDVDVKQGALMCLGSILKGLYESRVYKVEEIDLTKIKEIIPNFAKTFKSAYVHGSLLMLKAIGSFVEAFAATKLPLNDEELAEWHRIADRIIGDLNPQVRVIGKKAIKNIMEYYALDIDRSRKFMNVVKEYFPKLEAEEYEYTRVGAAIALGGIPAKLLKENITENKMLAVEIVEKLITVVEDEKFVHWIDARVAALNSIEKIISNVGITNFNISIIFVCLKRSIRDSTKTIHGLVGQHVRCAAISAFVQFLPLLEEAKMLKQETLDQIISLILEQCCERVDKLREFSAFQLRDLLQRHVLSNIVEREKLYSIFVNKKDIKWMIDAFEPLAPLLNCEFYHESILRGFINSVGGATGSWTQEKGLVKLEEFYRNNPEKANQLFQVFLNIFDEHHDKLIHLIIPVTAFGRLFSEGCFPQIEQEPDNFPSFVEVVKKISKIAYGGSVSVRNAALSSLATVFQTNLNSDTFKLAASTLMFLLTSRMPVIRSEAAKCFAQAVNVLDVTNDISMEELEEIYSLLKQTQWRDNESNFQEAAKRIQKEFNKVIENHRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3E8</accession>
    <name>A0A914Y3E8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y3E8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14713.t1">
        <property type="protein sequence ID" value="PSU_v2.g14713.t1"/>
        <property type="gene ID" value="PSU_v2.g14713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038169938" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14713.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22477" checksum="445BBD2868D5507A" modified="2023-02-22" version="1">MKYLLVVVAILAATISLATSETSPPKGPKVTDKVYFDITIGDEPAGRIVIGLFGKTVPKTVENFVELSKKSKGEGYAGSIFHRVIKDFMIQGGDFTKGDGTGGRSIYGEKFPDENFKLKHYGAGWLSMANSGKDTNGSQFFITVKKTSWLDGRHVVFGKVIEGMDVVRKIENTKTEAGDRPTKPIAISASGHIPVETPFSVEKEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Z6</accession>
    <name>A0A914Y4Z6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Z6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15273.t1">
        <property type="protein sequence ID" value="PSU_v2.g15273.t1"/>
        <property type="gene ID" value="PSU_v2.g15273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15273.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12803" checksum="BAAAF94F8E84429B" modified="2023-02-22" version="1">MILTIIQNGYSSDERETCSLFKGNHTITVTKADENGHKCNGIIAIAVCGGMCSSSEKGTHFFPHRENENSACVPIETTPIRHELTNCEEEALPTARWIEFNETKQCGCKSIDNPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y509</accession>
    <name>A0A914Y509_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y509"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14319.t1">
        <property type="protein sequence ID" value="PSU_v2.g14319.t1"/>
        <property type="gene ID" value="PSU_v2.g14319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:protein phosphatase type 2A complex"/>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14319.t1"/>
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    </evidence>
    <sequence length="265" mass="30718" checksum="52FF61CACF19952B" modified="2023-02-22" version="1">MGPVSPQKSRRHSSSLFNISANRELQKLPSLSEADPNAKEELFLEKIRQCCVVFDFSADPLSDLKYKEVKRSALNEVIDHVSNNHNVITEVIYPEAVRMFSLNIFRVLSPPSNPSGAEYDPDEDEPSLEAAWPHLQLVYEFFLRFLESPDFQANIAKRYIDQKFIIKLLDLFDSEDPRERDFLKTTLHRCYGKFLGLRSFIRKQINNIFYTFIYETERHNGIAELLEILGSIINGFAMPLKEEHKTFLLRVLLPLHKAKSLSIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y581</accession>
    <name>A0A914Y581_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Polyprotein allergen nematode domain-containing protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13929.t1"/>
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    <sequence length="126" mass="13759" checksum="5A11AC1C5D63AD74" modified="2023-02-22" version="1">MKVLAKKSLELKQKTEIDKLKVEGNFAGIKARVNTFFEAATGETKVKATEELKGACRELYHDILGEKAAEVKALKESGATDSELAKKIDELIAGVTDEAKKAKAEEYKADCKKIYGKIILKIITAG</sequence>
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    <accession>A0A914Y5X7</accession>
    <name>A0A914Y5X7_9BILA</name>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
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    </dbReference>
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            <begin position="1"/>
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        <location>
            <begin position="129"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
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            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15604.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="34897" checksum="B429D32A3351F793" modified="2023-02-22" version="1">MQISQFTETPLQGIDISTKSANTESFSTSDDESLTGTGTTDGNIENAFSSTSSLPGTKDSETTIIESEVSDQSSSTVFQLKNQSEMTTIVDPLENSDVSSSVTTKTLSYEESTGITKVSDLIDSTISTNTESLKETEKYETSSSSSTIKSETTKLTSESSTSLSLSLSESENEESKLSSTTTLAATIETTSSNLESTNNNNMLEKTTTSQQLSTKATVHELSTTSSMTTSDANKNVKTTMPSKTSINPISVDVSDSSDSNENLTNTFSTTTTISSLKNFTKIPSSSESNINATENLNLSIPTSSASPPNSNRYKFNIILWLPTLCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y740</accession>
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        <submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            </authorList>
        </citation>
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        <location>
            <begin position="1"/>
            <end position="40"/>
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    </feature>
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        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
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        <location>
            <begin position="14"/>
            <end position="24"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15090.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18949" checksum="CCA1EB6C2B2A8ACB" modified="2023-02-22" version="1">MKSDNPGMPKITRGDSTTSTQSIENEAEIMPSKILIPPSPLPALRKKSAPLWLNDYIESWVHEQRQIETCSIDAGSSHDTTADSIYSKSSPDESATSSSTTSTYNSEDNLNESICSDTNKADELITEVQLLRLVNDRQKEQIEQMNGEKRELLREVERLRQITNYVSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y848</accession>
    <name>A0A914Y848_9BILA</name>
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        <submittedName>
            <fullName evidence="4">Beta-lactamase-related domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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                <consortium name="WormBaseParasite"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14924.t1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27469" checksum="EDA9C6C7518547D0" modified="2023-02-22" version="1">MSEKISTLNSVHFVIQTCLKWFKAIAILISLWIFGIFKRKPKMIHVQGFVESGFEDVKEAFVQNLESNWEHQGASLTVFHKNKLVVDLWGGYSDKECRRLWQKDTISVAFSSTKAIASLCIALLVDKHLISYDDKITKFWPEFGKHGKGAVTIQWVLSHLSGLAYFDTPITESDARDWKKMAKIIENEKPKWEPGTAVGYHAITFGWICDQIIRRTDPQQRSLTQFFNDEIRGNSGKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y874</accession>
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        <submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGT"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16398.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28466" checksum="BEEBC8600970249C" modified="2023-02-22" version="1">MAGGNNSETNENHQKAAQTLIEEGDECVKASKFNDAIEKYNEAIKLNRDPLYFCCRAAAYCRLEEYDLALQDCRSALEIDDKCAKAYGRMGLVFYHQNRYDASLEAHETALALDPFYMLDENYKSHLDVIKEKVGEAQNFCATLFGGTGEVSDFSDFMNNEYVMQAAMQMMKDPNMQNRLESMMEQFMGGSAAAGESFGELFAAGKNMAQQMQQANLELLEQLRDRFASTSVFEEGHQQIEDSSSAENSQHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8V7</accession>
    <name>A0A914Y8V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8V7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15886.t1">
        <property type="protein sequence ID" value="PSU_v2.g15886.t1"/>
        <property type="gene ID" value="PSU_v2.g15886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15886.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13981" checksum="319952D93ABC08D2" modified="2023-02-22" version="1">MTVSLPTEQADDRKPFSVEVELTDDFDYNLITQHILSKKECKTLHTSAQLSFKTSSFIPQLLDEISIRIKERYGSKPMFQSLTCQTESEKSGCERGAFVISVDEERCSAILSDIFNGCAIVFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9H3</accession>
    <name>A0A914Y9H3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9H3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14192.t1">
        <property type="protein sequence ID" value="PSU_v2.g14192.t1"/>
        <property type="gene ID" value="PSU_v2.g14192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14192.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9808" checksum="8B593F83C46A6C58" modified="2023-02-22" version="1">MGQRATDMWTSYSPYQMSRPMGYPTTTMQYGAAAASAAAFGSMSNQGIQFADSEDIYRSLQRSQQQAVAAAANNPLQQYQNQNNNQNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9R1</accession>
    <name>A0A914Y9R1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Concentrative nucleoside transporter C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9R1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1550.t1">
        <property type="protein sequence ID" value="PSU_v2.g1550.t1"/>
        <property type="gene ID" value="PSU_v2.g1550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037157106" evidence="2">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1550.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="23527" checksum="0060D1C6602C7EA5" modified="2023-02-22" version="1">MQVVLKWMAWFMQITLGTTAAESLNSCACIFLGQSEAPLLIKPYLMKMTASELHAVMTSGFACIAGSLFAAYISFGACPGYLLSSTVMSAPGSLACSKILFPETKRSKLQNIEDLELPKGEESNALECISNGAVMAVELVMAIVANLIVFLALLAFIDNVIGWTGSLIGYNDWSFELIVGYVFYPLAFVMGVTEDSEQTKTVAQLMGTKTVLNGKYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9R9</accession>
    <name>A0A914Y9R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9R9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16958.t1">
        <property type="protein sequence ID" value="PSU_v2.g16958.t1"/>
        <property type="gene ID" value="PSU_v2.g16958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF58">
        <property type="entry name" value="PEROXIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16958.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14967" checksum="2DD1E3CBC1B6D3BA" modified="2023-02-22" version="1">MLVSIYLTQCDRYMKSNIILENIDMYVGSLLEDPIEGALVGPTLACIIGRQFRHLRDGDRFYFENPDIFTEEQIKELHKASLRKILCDVGEDMKEIPRNAFDQTKDPSDLVECKRLQSPDWKVWKDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9X5</accession>
    <name>A0A914Y9X5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-type ATPase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9X5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15565.t1">
        <property type="protein sequence ID" value="PSU_v2.g15565.t1"/>
        <property type="gene ID" value="PSU_v2.g15565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF215">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="9">
        <location>
            <begin position="426"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15565.t1"/>
        </source>
    </evidence>
    <sequence length="489" mass="55550" checksum="BCBAC955D060008F" modified="2023-02-22" version="1">MVANQKYDQINNGYMEGEAFRISNSLFYLRPEDYPPTAESTPTNERSGRSTNIQTPSSSRFVSILNPADIVRRLSSLNISSLFRKEEKVKLKSKKQLKIYEAESPDEYCLVNAAKSYGFKLVSRDLSHVNVTLPTQREYPRERRLRLSVQKILKFDSNRKRMSVVLDLGDRKLLFCKGADDEILANLCQKTLEQNLQAKTIVENSKVFLKQYSRNGLRTLCMAMKFMSNEEYNRWEVQHEVIENSNIPDQDEQLSQSYRRLETNLKFLGLTAIEDRLQDGVEETISSLRKAGIQIWVLTGDKKDTAINIAKSCQLFDSQTEICACSTEEDLINLLSFPGKYNVAFSAPIVKLLENGNLTAIAAIQKASAVLCYRMTPCEKETVVKTVKKYLKGKVLAVGDGANDVPMIQSADVGIGISGQEGLQAVMASDFALARFKFLKKLLLVHGHWFYYRLANVLLYFLYKNAMFVFVLYWAQFYSGFSANGIMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA08</accession>
    <name>A0A914YA08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16271.t1">
        <property type="protein sequence ID" value="PSU_v2.g16271.t1"/>
        <property type="gene ID" value="PSU_v2.g16271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16271.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24463" checksum="073620FAF420C397" modified="2023-02-22" version="1">MRTAQSIFMKKPKIVWYIFFGIAAIVAVLCIPTYYVHHVKPILLRSESGKLLEIIDYYTVDISDFALQNKCKLFKTNLWIIGICLKAIPCFLLLWFTLALMMRLHRNNTRRAMLLYSKSNKGARKRKQNYDRTTFTLIVVLTVFLTTEMPQGAITCLNGFYTNDVHMVIYMNLANVLDLLSLINCYVGFIAYCFLCSKYRQTFMIMIVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAC2</accession>
    <name>A0A914YAC2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein orai</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Store-operated calcium channel</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1623.t1">
        <property type="protein sequence ID" value="PSU_v2.g1623.t1"/>
        <property type="gene ID" value="PSU_v2.g1623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.140:FF:000003">
        <property type="entry name" value="Protein orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF7">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1623.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28448" checksum="341F1A01B2CFBEE3" modified="2023-02-22" version="1">MHSHNKSSAKEDSEDVKMNPALFNPLLFLPSFNAQNQRDEESAGNELDEFNLHRGELSVSEKYRYDLSRAQLKATSNTSALLAGFAMVALVELHYDEKMPRYLLIILGIVTTLLVSFHLIALMISTCLLPYIDANGCTKDSPHNRLKFYIELSWLFSTCIGLLLFLVEIGIIFFVKFLAIDFILGAYITTAILIPVFIVFILISCLLHRERYSHSVERVNTKVKFLENIIESGNSNPLLSTKQRPANFEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB79</accession>
    <name>A0A914YB79_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YB79"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16017.t1">
        <property type="protein sequence ID" value="PSU_v2.g16017.t1"/>
        <property type="gene ID" value="PSU_v2.g16017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="645"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="604"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16017.t1"/>
        </source>
    </evidence>
    <sequence length="865" mass="96671" checksum="21123B81DFA4020F" modified="2023-02-22" version="1">MDSESKEEGSGRFTSDSSPEEWEDISRENIDAEAKKDVLNIKADQKSDKPITDNSVQSKSNSSNVNKSDSSSDQNSDNSSKSSSVSEAAINSDEVDIIESEEVQTNQLDASAQGFDPESVHHMHDGSDDESAAEFHPHPKPKLHVLTKPIDNTEVETDSVDTPRPEEIMKITDKMVLGFDREAYKRRKDDKIIEEEEVSSSTGGNNSPVIAADAKVDSSSESDSSNNNKEDAKDKIGISKEAECILSGTIKIEKIIDKPYEVEDVLEIIDETHESDGNPVESEEIKNQLKSEAKEMQDSIHLKILEVREKENVENDEQENENKKVVDANVQPPLSSSDAKIVVKREDHESTTDESDKSESSESDDDSESNKSGEAADNERKKDKNINIKKEQQKDFVLGLPLPLPLHQQQQQQQQQQKKAESDDSEDEDKIGIETAARKRLDLREKRKRRETTSPRPQDLIEAFKFANFQTRQKLDKQQSLETPMAIKVPPPTPSEGFESVKLKAPPEFAAPGPEVFHEVPIDVVDEKRHIAFDIDDITESIKKRINDDDDEEYNHPYEKSRLEKFVNYLLCRKDLVDQKLTEKPVKFWDLFKYGNRGDTILVIFGLLLAAICGICQPLFAILSGRLANVLLLSDIDDPEFFSEGTQACILFVVIGAFLVVIAFAQFLCFNIACTRITRRIRNAYLLSILRQNPAWFEKNHSGALNTKLNDNIERIYEGIGDKLGLLTRNMVQYVTGIIVALFKISKASRDEMKVYGQAGCIAEEAVTAYRTVAAFNAQETEVNRYRSELENGVKSGVRKALYTGALSGVLLALVMIFMGTALLYGTFLHSIGVIKTPGDVFIVLMAIMSGAYHLGNASPHLMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBG4</accession>
    <name>A0A914YBG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1676.t1">
        <property type="protein sequence ID" value="PSU_v2.g1676.t1"/>
        <property type="gene ID" value="PSU_v2.g1676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1676.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17262" checksum="855D86AE1DE5A3AD" modified="2023-02-22" version="1">MVGMDTLSRKQLVEIIRAAKSEHTVLLATHYMDVADDVSDRIIILSNGKIVCNGSSNFLKANVETGFLLTVEFTRAIGMESYQQFADVVLSIVTKHCKNASIDGSANRQFTIFLPRGTQRSFPLIFNELETQKDALQIDSYDIRANTLEQVFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBP1</accession>
    <name>A0A914YBP1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBP1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14901.t1">
        <property type="protein sequence ID" value="PSU_v2.g14901.t1"/>
        <property type="gene ID" value="PSU_v2.g14901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14901.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12401" checksum="30663FA9C119649C" modified="2023-02-22" version="1">MADVQSPAIEALSVGLKKGHAVTKIQKKTRASAFKGRLTKKTRIVREIVREITGFAPYERRVMELLRISRDKKALKFIKARIGQHTRAKRKRDEIQSIITNMRKHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBS1</accession>
    <name>A0A914YBS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gag protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16872.t1">
        <property type="protein sequence ID" value="PSU_v2.g16872.t1"/>
        <property type="gene ID" value="PSU_v2.g16872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16872.t1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29825" checksum="425EED7C30A9C5BA" modified="2023-02-22" version="1">MTPTPSVQQASGDATVKTSVHIPTIPVFVHNPTNPSSASTWLKQIEMKFKLAPGLTAEHKIAAVCAAFDETTFDRVTSALLPTDIETMTDWAKFKDVFINLFDMKRSLFADRYNTFQIEWLGPAHESLQECVSRIRRSVTHFDFSNFSANELSTLLLLMSMKAAALEPLRSLLLNALIKNPKESLEDVATLLENALLTERDQKLPEQKHINFVKKVGPSNSSKPPPRTPCPCCGAAHWRADCKFKNAICHTCGIKGHISKLDLSMLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBT9</accession>
    <name>A0A914YBT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBT9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16752.t1">
        <property type="protein sequence ID" value="PSU_v2.g16752.t1"/>
        <property type="gene ID" value="PSU_v2.g16752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036903483" evidence="1">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16752.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9299" checksum="69D54AB9321F2B2D" modified="2023-02-22" version="1">MIQRNIFVLFALSFSIVCFAAPVITNDAKTGEDDGIKISLEKLKFIPAELLCTLCHRVVIKLQHDLQENPMDFQIVSLSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEC0</accession>
    <name>A0A914YEC0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">limulus clotting factor C</fullName>
            <ecNumber evidence="9">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914YEC0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17790.t1">
        <property type="protein sequence ID" value="PSU_v2.g17790.t1"/>
        <property type="gene ID" value="PSU_v2.g17790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037386944" description="limulus clotting factor C" evidence="11">
        <location>
            <begin position="19"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="35"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17790.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31336" checksum="1982B412A0023B49" modified="2023-02-22" version="1">MVKTFITVMALAITVVYAQQKCGQTPIPPNIGSKVVGGQIATQYSWPWQIVWCSNGWFGCDLECGGSIIGSHWAMTAGHCVYGNTNSPGNFRVKTGVFDERKANEGGEVVHKVKKIYLHPQYNPYPDPLYDIALIELVEDVTFNNHTQPICLPIQDNSTIVEPNMAWATGWGTTTEDGDISNKLRQVNVPFVNYKTCEDEYPGDITEKVMVCAGTKGKDTCQGDSGGPLVVKNKNGAWFQYGITSFGAGCAEYKHPGIYSRVTAYCDFIKTTTNGAITCQDPDTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG08</accession>
    <name>A0A914YG08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM91A1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YG08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16278.t1">
        <property type="protein sequence ID" value="PSU_v2.g16278.t1"/>
        <property type="gene ID" value="PSU_v2.g16278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="4">
        <location>
            <begin position="410"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16278.t1"/>
        </source>
    </evidence>
    <sequence length="834" mass="93725" checksum="6B7E3B5860D2F621" modified="2023-02-22" version="1">MSVVTSTDEIEDSIQKRIPWLRLPESQRVALGNSQKEYDKRILDFSIRNQIRYKGNLVKQVKKNEEEYYESLLNYSRKKLMLFPYHLSDVVVKGLRVTPFTYYINMMADIMEAEKSYDSLPNFTAADGVRLLGIGRNQYIDLMNQSRSSRRLFRRNKNVRELLPIHPVNFHIEPWFLICDGCIVENDIRVLTPIEKEIVDKLLDTGPIICGTVDKDLIRSLYNKGLVYFEVPITNIDYVYVPTLDGFVMNRVQGDFLETLLYKIFVTLDGQMTAKDIAEVLDTDDELVRNAISVFCRLGFAKKRQTGVESMPLHATWYGTSPDNSINPSPNISSLKDHHHPSNAVTNNTVDLSSSLVSGDKTEFDEDEDLVSALDSILSESPSESSNVNNQSGITSALPTPTPSVSDTGSKRIAFIFDSTLTAFLMMGNLSTSLKSHAVTLFEVGKLGDEAVDNFVEELHNVKFFAEGEAQRYSEHALTLLHTIEGLRTSNELDLIRGESLLNLDKNARQRVIQKSYRAIFSMAPINPEACSLPPISSVAFFGTPCVEVGSPWFRLWLYEVVGNGLPSVYIPMGTRVRRIPPLLWTSPKVVLSTGTHEPLILPTGNALLTLNETLLNAAVLLQGYPDSVDDAEVINIPFSFKDDFDEKNDAAIGRDERAFVNHPSVQKLRKVLSLDLLCGYIVLVKYTPKVFYPKSFYPIPKLSDDETDSDSDDFENVKKDSSSTAADASTLISSNKDQQERIESPRSSAQSPDSLFAIPTTASWSNSVTKDPRKIVSKKFRLDDGESFEDYRLFDCLFGAPLFDEHLNKQICIKIITADLLSSEKKVLELELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGA6</accession>
    <name>A0A914YGA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGA6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18481.t1">
        <property type="protein sequence ID" value="PSU_v2.g18481.t1"/>
        <property type="gene ID" value="PSU_v2.g18481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18481.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="11033" checksum="281176C53A51E1FC" modified="2023-02-22" version="1">MVSDENAFSGYRTIYEIPAQHIRLFAPWIFDENMPLVEVYKSVLNSSDQKLLRDALNENRDDRRMMKLFDASIKILCEDRKSQDVLQKYLESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGH4</accession>
    <name>A0A914YGH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGH4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16439.t1">
        <property type="protein sequence ID" value="PSU_v2.g16439.t1"/>
        <property type="gene ID" value="PSU_v2.g16439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036745650" evidence="2">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16439.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17052" checksum="D1950DDE9B81449D" modified="2023-02-22" version="1">MKFDSILLIFAFFFILAPSIFAVECSSSDMPYFEIECPACTFYICGKKNGAGCPDDFFHDCSNFGEAIKFIDSKNYLYLNYFDGFVTYISGCEQELDGQPCLRDKKENFEKEIEKYESGILWNNSNCQKSAFKVIGIIGIAWIFVIFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHL5</accession>
    <name>A0A914YHL5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small integral membrane protein 14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHL5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18286.t1">
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        <property type="gene ID" value="PSU_v2.g18286"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="PANTHER" id="PTHR31019">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF2615"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18286.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11010" checksum="B131646D64B3FDED" modified="2023-02-22" version="1">MAYEDDPCECLLSHEAMMQRLLNILRQSQDECSEGGNCTTEINISTNTFTIGLITLLSAFAMLMFYTRPNSLRSSSNLSNEKSRNNFGGRDQQPPPSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI14</accession>
    <name>A0A914YI14_9BILA</name>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="157"/>
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        <location>
            <begin position="623"/>
            <end position="644"/>
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        <location>
            <begin position="220"/>
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        <location>
            <begin position="706"/>
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    </feature>
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        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1912.t1"/>
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    </evidence>
    <sequence length="772" mass="88257" checksum="BF0DB6FEC0204EEC" modified="2023-02-22" version="1">MSFLADYAKSAIIQAQKRIDTVLDIRPEEEADDEEEENVLQNDSIEAEQEEISNVENGITKVGEEEAKAEKHDTWQLEGPSQNDPIVTEEPNPMRDLHVHGDVVICPDSPNSLSPTDDGRYPHASRSHTNTDDTQVSDFKSELPDPSEQNSLQPHFDPNRDEIVTIASSDIEVIRANDEWSTVSSHKPMKTDALSVSNIPPSIHHVVQSLNSHGNDEHQLASLKSQINMKDRQIEDLSASCKSLTQINNTLKQQNKKLTDKLSLMSKMQKDLVAKEVQIDELFAEGQKLSELNGRQSKEIKRLRQELSQLEIVTTARDAAILELQTLSKKLEAAEQNIAELEAQVDAAESANEKVLMEMSQNQEDADMSSKQFAEQQNKFEEAERIIHQLKTELALSKKEKNDIIAERDAEQRARIKFQTDMAIKDEKTNGILMDNESFKLKNERLKESIHELELRIQKYMENERNAAEQLAVATGPLLIRIDELENELKASRYDYNNILTRCKTLEANRDESDVIKTKFETKFQEQHSEILNLLRENQNLKHQLQTLEAKNSAVEQDSSFQLKALKKQLAEESEALSKIKKNFQNIMHDLKVQNEKNAELSPKVAAQEGEIQKLNSKISELSQTKSTEMFTPRPESAASFGRRNTSSNLSDDFVNTSHLGFVDYNYSGTSNEFTALQSELLNMTNLYNQTLNRVQILQTELFGQHKEYQLQIKLKEMDYERLNNDYEELLSEYGARVEQIEELQMDLDEVRKIVAQQAETVAKLEHELRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIE2</accession>
    <name>A0A914YIE2_9BILA</name>
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        <name type="scientific">Panagrolaimus superbus</name>
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            </authorList>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19082.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11830" checksum="9057DCFBECB4887A" modified="2023-02-22" version="1">MKEKIERSSKDFMVRSVSRLPKFTAQEKRDLLGSADFLGVNYYRSQTVRPRKPNEYAYLDNYLMNMDAGISTSYFNNWELFDWIWNTPDGLRQDILYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJY1</accession>
    <name>A0A914YJY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
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    </dbReference>
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        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17613.t1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37697" checksum="28CD9D01DD10A4B9" modified="2023-02-22" version="1">MISVCRSTMLKDEKKLFNVEAIKLAPQSIKRKMEQRFPKLLSAIIGIYHTDIPYTIWRCTKIQDEEDFKKLLPLLACASSNAKVFSKACNTYLRRKTETLKLSGTLLSLTDSKTINAALSKIIGSDWTYLLKQKESFDELKDEEEQKLFIMGSVQAKKPDSDAVLEKFLQTSVARKVSNKNKYPSIEARQEYLKSKFQEFKFSDQVESNDDEDTEFDELVEPQRKKPRISLKRCNKQSCKQFKTDPLVQKFIQKLDDSNMITAFACIMKNFNAACTACLSEICSVKEDDFDENGVLNVEKVMEKLPFVESDESSTSPLSDSDESSISLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK68</accession>
    <name>A0A914YK68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19726.t1">
        <property type="protein sequence ID" value="PSU_v2.g19726.t1"/>
        <property type="gene ID" value="PSU_v2.g19726"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19726.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9354" checksum="ACECEA3E3B403F1B" modified="2023-02-22" version="1">MKLRGVTITAEVAKLLHYKKFKHMVKNYGNNECVIIRFPQITPHRTGHVYTRDAVKRYVGIFQKGLIKNDYTIVPFGYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKA2</accession>
    <name>A0A914YKA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BED-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YKA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19957.t1">
        <property type="protein sequence ID" value="PSU_v2.g19957.t1"/>
        <property type="gene ID" value="PSU_v2.g19957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19957.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="36277" checksum="72144690EAB97204" modified="2023-02-22" version="1">MSNFTSKYDKYFSKIYTENKHLYQWTCRLCGLVTAPTIHTTTEIRRHHLKTRHPEDFADIEPRKVKAPIGVKKRKVKDIIIANTSLKKVRTENDINSDKIDNTIMELISSSSFPISTINDPAFDRLLKLLNPIYILKRWIFTFLTCFYNSFFKNDELKPQHFILALQPINLDKIMLKLYERLEEIFGEFNLDWSKVTHIIQAGNLESEDLECDPEWHVEICLSLGLQVSIEDAMKDVQALDTVILKVKKLLRKLRKSKTLKQAFIDYQKLEDFPEKCLDSEVQIFWDILYSIFLSFQQNKISLQVFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKF1</accession>
    <name>A0A914YKF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKF1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19819.t1">
        <property type="protein sequence ID" value="PSU_v2.g19819.t1"/>
        <property type="gene ID" value="PSU_v2.g19819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19819.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23521" checksum="68FB60AFC208549C" modified="2023-02-22" version="1">MKLEEGKAESKGLSKGDQLKLEALGCKDIPDLINRFRQLQVKKETIVQSKVLGSSAQLAPLTRAQSTVSITSSEACQSQQKTIAKGGSLSCDKSRIANEVSAKVPIPMPEKFNGKSRIELERYLRYYVQAVNSRGYTDSDKAMMLGNYAPSLQFVHDKLIYNNASYAEVKSGLLDALGTNSSAATYTLRASLDRFKKADDKLYKATLEEIEPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKN4</accession>
    <name>A0A914YKN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKN4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20902.t1">
        <property type="protein sequence ID" value="PSU_v2.g20902.t1"/>
        <property type="gene ID" value="PSU_v2.g20902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF194">
        <property type="entry name" value="G PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20902.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="40077" checksum="BC250C2A85D48CFA" modified="2023-02-22" version="1">MDRIRQRFSDLMGQLCCRSERDFNHSPEERKNKDKSDNVMRFFMAGMGSAGKSTLIRQLQLLSNKNTNYKFCNDDWTELQTTEIETEAWQIAIRKNILDCFDIFIKQIKKREEEFDDEENENFAQIIEDICDQDNAFDEIIFDESFKESIEVFDEDYDPSDEDKVHSRKPTVNMHNYKFMLNDTKLEIHDVGGQKSELLKITDYLHKWSADSKEDDKNFILLVVSMSDYNVPHSQYPQHTLLDESMEYMKLLLNNAVAENCKLLIFFNKKDRFKEKLNDEHCRQDIDYLKEYLSSSQYKEYIKTGKYEPKIMYNAITAKFIENIKIKYPNKSCYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLM6</accession>
    <name>A0A914YLM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18224.t1">
        <property type="protein sequence ID" value="PSU_v2.g18224.t1"/>
        <property type="gene ID" value="PSU_v2.g18224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18224.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11720" checksum="682850D2C346368C" modified="2023-02-22" version="1">MQQKDYREISAVPSSKPYVSHMQYKDSRGQSVTLFPAFRSVDTLHDISRIQSPIKLNTVPLISRNQDKWANKYHEIVREYGPSKDDPESLFLFGKDELYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YML9</accession>
    <name>A0A914YML9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YML9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18574.t1">
        <property type="protein sequence ID" value="PSU_v2.g18574.t1"/>
        <property type="gene ID" value="PSU_v2.g18574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18574.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17753" checksum="7050D4691CE6A8E7" modified="2023-02-22" version="1">MEESLKSIDDLLLILNKSSIALQNAKEIRKNVEADYQKAALLELKAKNESIKQDQLEETVRNIAIRMGSFEVVNDEILGEFEGMMDESQKALRKRITKKLKAQKEKYNLEKNRDDIKRDFLLLKKELQQLQNIYDSIPDKCFNHVRLEQSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN96</accession>
    <name>A0A914YN96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translation initiation factor IF- 2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YN96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20871.t1">
        <property type="protein sequence ID" value="PSU_v2.g20871.t1"/>
        <property type="gene ID" value="PSU_v2.g20871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF5">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor G-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor IF- 2" evidence="6">
        <location>
            <begin position="57"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20871.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19488" checksum="21A8638BC4C53149" modified="2023-02-22" version="1">MLNETGKSLNSAGPSIPVEIQGLTEVPAAGDELVVMADERKAREIALFRQGKFRDVKLSRQQAAKLESMFDNLGEGMQTLSLIIKTDVQGSQEALVQSLVKLSTDEVRVVVVHAAVGGISESDVNLAIASNAVVIGFNVRAEQSAKKLAEANGIDLRYYNIIYDAVDEVKAALLQRVAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNC3</accession>
    <name>A0A914YNC3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914YNC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18832.t1">
        <property type="protein sequence ID" value="PSU_v2.g18832.t1"/>
        <property type="gene ID" value="PSU_v2.g18832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF52">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="92"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18832.t1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47708" checksum="E3104FB5D7271427" modified="2023-02-22" version="1">MKTVAAYFDRKPIENEDEEEESQISSGNGNNSQGLVDNFKRNIGNAWNSLAYGKWRRKEDILEDCNSQIWLLGRCYLPEGQGSSYEENCPLFFQDYHSRIWLTYRRDFPPLIPTNKTTDCGWGCMIRSAQMLVAQALTILFCGRAYRRISKPNIEMLQTIIKLFEDKDEADLGLHRLMSIATSQTDEKAVGQWYSPSRSLALLRDAINNSEHHLLQNVQIYLSADNCVVTSEVEILSCGWTKAIILVVCVRLGTKKINECYKHHVKSVLSMESSIGLVGGKPKHSVYFVGFHGDYLFDLDPHFAQKYSNLDENDSKIWETFHCQKPTRMLVEEMDPSCAVGFLVKSQTEFNQLIQQLSDSGIIENQSNRALKRSKSSHEGNSLFSVIDERIPSELMLCEYETPNLADDEDELHGFEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPB9</accession>
    <name>A0A914YPB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2684.t1">
        <property type="protein sequence ID" value="PSU_v2.g2684.t1"/>
        <property type="gene ID" value="PSU_v2.g2684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF21">
        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2684.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18723" checksum="2E82D01E83E383C4" modified="2023-02-22" version="1">MQAAINAAGTGQTDISQAQIFGNIEIALLYLPQERELIVNVLGALDLPPRRDGALRNPYAKLFLLPDRSEKSIRQTTVLAETISPQWNESFYYRNLTEPILMSRVLEVTVWDYDKYEANAFLGEVLIDFSTVLLDNQPFSYTLMEMDDENPVRLVRDLIYPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPF8</accession>
    <name>A0A914YPF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amine oxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21323.t1">
        <property type="protein sequence ID" value="PSU_v2.g21323.t1"/>
        <property type="gene ID" value="PSU_v2.g21323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21323.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26344" checksum="14A72FDCC9178EB6" modified="2023-02-22" version="1">MGFGSLNKAVLFFEKPFWGIQEDIFSRLSETTEARGECFQFFAVPKEPVLIALISGTAANIGDGPENDKLLKNRTMLFLRSTFPNCPVEPIEFIVTRWHRDKFARGCYSYVSVDAQDRDHEVLGEPICDTHGTPRIFFGGEHTLCRWPSTIHGAMLSGMREATRIADTFYGTLPVVAHEELISKVKLESMNGVKRGEDCDVKIEEESDIDFELSDDDPMTGENIDEKEAEKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPN6</accession>
    <name>A0A914YPN6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YPN6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1932.t1">
        <property type="protein sequence ID" value="PSU_v2.g1932.t1"/>
        <property type="gene ID" value="PSU_v2.g1932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.460:FF:000002">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000004">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.460">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036944">
        <property type="entry name" value="PPIase_FKBP_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008150">
        <property type="entry name" value="PRK10902.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="151"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1932.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="27477" checksum="5FB643D6B0760E18" modified="2023-02-22" version="1">MAVALHAPITFAAEAAKPATTADSKAAFKNDDQKSAYALGASLGRYMENSLKEQEKLGIKLDKDQLIAGVQDAFADKSKLSDQEIEQTLQAFEARVKSSAQAKMEKDAADNEAKGKEYREKFAKEKGVKTSSTGLVYQVVEAGKGEAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPGIPPNSTLVFDVELLDVKPAPKADAKPEADAKAADSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSE1</accession>
    <name>A0A914YSE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSE1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3084.t1">
        <property type="protein sequence ID" value="PSU_v2.g3084.t1"/>
        <property type="gene ID" value="PSU_v2.g3084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3084.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21630" checksum="8F755B5EACE75B5F" modified="2023-02-22" version="1">MAKRTAEAETTAAGIPDEPKEKAAKLDSINIEDEETPLLDVDVEAIKHGETEKAEEELNNKVEVEVLEEADENDAKENGGGEEPIIDEPEDDEGHQHQQQPQQHHNNNNNVQHLHEEGEVEEEEEEEITKNDEDNEKSSPPPIILPEDVVKDVEFKVPHLPPAKIPHDSATTVVSTKESAATSDATKDSEENGSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSH3</accession>
    <name>A0A914YSH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20355.t1">
        <property type="protein sequence ID" value="PSU_v2.g20355.t1"/>
        <property type="gene ID" value="PSU_v2.g20355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20355.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13747" checksum="12FDC7922F75C84D" modified="2023-02-22" version="1">MNSQDYIKVMEAHLLPFLRGPRRRMFAYQQDNAAIHVSRQSKAWFESKNVKLHEHPPCSPDLNPMEKFFGGYLVRKVYANGKKYQTVAKFETSIIDAWESIPQSLINNLIQSNEKSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YST3</accession>
    <name>A0A914YST3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dopey N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YST3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g322.t1">
        <property type="protein sequence ID" value="PSU_v2.g322.t1"/>
        <property type="gene ID" value="PSU_v2.g322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g322.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15774" checksum="57FE171DDC5E2CA4" modified="2023-02-22" version="1">MGDSLKPSLPGFIATVSLGLEEGTEFFPRSNDLLQRLIEAVGNEAFFASLWEAVLHSPSVRLPALYFVNSRFDKRKPLGEQFFMVAGGDHVDHMIAALCAVAEDFSGPVLMHRHLLDFLLSAFPLNSAHGYVFNSTNISMAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTE9</accession>
    <name>A0A914YTE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTE9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3964.t1">
        <property type="protein sequence ID" value="PSU_v2.g3964.t1"/>
        <property type="gene ID" value="PSU_v2.g3964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3964.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16291" checksum="B46629C7FF587E7E" modified="2023-02-22" version="1">MSAIESQSQSQAPTPAKEVSVGTAKTKQELPGGILLRSIGLSFEKCTAHGTDLCDLIEEVFEYVFEELHGIYDGLNLDKNAIYRYEFRSSALTVDKYFGFQAPEFKQATCRDMIKKMMNIFDCDQFFNLFRSVMIVNLTYTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTP8</accession>
    <name>A0A914YTP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTP8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g405.t1">
        <property type="protein sequence ID" value="PSU_v2.g405.t1"/>
        <property type="gene ID" value="PSU_v2.g405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g405.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22752" checksum="7E8CBAB4902A54C9" modified="2023-02-22" version="1">MLYGTDWAGNHAHDAIKGQAHTFFTGVVDFYDPAKNTIGFLGEEFHGPVAFALHGMMAPAFMLTVAGFLLAALFYLWKPDLSGKARKDLRSAGVGAGKQVRLRQAVDRWLCRWQRQAGQGLALDRQQHRRRRGQSLGTCCGRRSRRAASYPIRFPLSLRLRDDHRPDCPAGRADALPALMTCTDKKTCRTGLYSVSSSGCRSSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUM9</accession>
    <name>A0A914YUM9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial</fullName>
            <ecNumber evidence="7">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aminoacetone synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glycine + acetyl-CoA = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:20738"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YUM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3375.t1">
        <property type="protein sequence ID" value="PSU_v2.g3375.t1"/>
        <property type="gene ID" value="PSU_v2.g3375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005394">
        <property type="entry name" value="PRK06939.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="61"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3375.t1"/>
        </source>
    </evidence>
    <sequence length="415" mass="45886" checksum="B8F0A2DD79AC2841" modified="2023-02-22" version="1">MLRFFPVIRISTRGYSSARAELVSQLKDELKNIRDAGTYKTERVIVGRQGMEIDVEGFKGKYLNFCANNYLGLSSHPDVIKAGKDVLESHGAGLSSVRFICGTQNIHRKLEKKIAQFHGRDDAILYAACFDANAGVFEVLTTKDDAIITDELNHASIIDGIRLSKAKRLLYKHLDLADLEQKLNEAKDCRRRVIVTDGVFSMDGDLAPLKEITALAKKYNALLFLDECHATGFIGKTGRGTEELYGLNGQVDIINSTLGKALGGAMGGYTTGPQEFIDLLRQKSRPYLFSNSLAPSIVGSTLKVFDMLLEHNTFAHALHDNVDHFRKAMNEAGFKVLGNPTHPICPVLLGEARLAEQFAKQMLDEGIYVIGFSYPVVPNGKARIRVQISAAHTKEQIDKCISAFKKIGRQLKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVF0</accession>
    <name>A0A914YVF0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVF0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3957.t1">
        <property type="protein sequence ID" value="PSU_v2.g3957.t1"/>
        <property type="gene ID" value="PSU_v2.g3957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3957.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13575" checksum="814A03834688C62D" modified="2023-02-22" version="1">MLRSIIRLGPKFIKTKDYVFEDKSSIKPNLVKTWCIVAVAATFGSVIIVNFAVPTPDIQFDIKYYTSPDFKQYVDTNGTMTHSKETKNAVRAYYRDEESSKFYKTMLDYRSSFTEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVV5</accession>
    <name>A0A914YVV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Semialdehyde dehydrogenase NAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVV5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2213.t1">
        <property type="protein sequence ID" value="PSU_v2.g2213.t1"/>
        <property type="gene ID" value="PSU_v2.g2213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18129">
        <property type="entry name" value="ASADH_C_USG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17894">
        <property type="entry name" value="ASADH_USG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005957">
        <property type="entry name" value="PRK08040.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46278:SF2">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46278">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2213.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="28863" checksum="3D1C59E68DF003EE" modified="2023-02-22" version="1">MSEGWNIAVLGATGAVGEALLETLAERQFPVGEIYALARNESAGEQLRFGGKTITVQDAAEFDWTQAQLAFFVAGKEATAAWVEEATNSASAQGKKAVDALAGQSAKLLNGIPIDEEDFFGRQLAFNMLPLLPDSEGSVREERRIVDEVRKILQDEGLMISASVVQAPVFYGHAQMVNFEALRPLAAEEARDAFVQGEDIVLSEENEFPTQVGDASGTPHLSVGCVRNDYGMPEQVQFWSVADNVRFGGALMAVKIAEKLVQEYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX62</accession>
    <name>A0A914YX62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX62"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4236.t1">
        <property type="protein sequence ID" value="PSU_v2.g4236.t1"/>
        <property type="gene ID" value="PSU_v2.g4236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF14">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4236.t1"/>
        </source>
    </evidence>
    <sequence length="671" mass="76644" checksum="FFBC8759A68736AE" modified="2023-02-22" version="1">MSLKRLSSFKKQLCGNGAIQASDECKKDVSYLFCSLNDFINYYSIECPGKENVEACTTCQREADEVYQKNSWISTWIDSIGKMPSGISDGNYHWLGDYEQCQMLKLENKFNGHYCMIEFEVPDTILNTQCDNQPLEVHLGICLPASCKLNETKAIIEDVAQHKMGVHCEPPSEWHTREITFLIVILIWCFIIFAATIWIWKFGAPESKTYVDNIVEALSLQHNLRKCLRTTRKRTMFHSIDGLQVVSIALLVNGNIFFLIMEYLENVSFSYTSSEDIFMQPVINYSVYADGLLAFLGFRIGLHVLRKGYSDSSTFWKHLLSRFFRVWPPYAFVTLFVSHLYIRLGYGPMWSHNDLPYRCEKTWWENLLLINNILGFKETCLDGGFLFALEAQFYLVAIVIIYIRRNSKTASNTVIGMLITISTAYIFIVTNIFKTYATLIPTAPAFNANHESKYANYVNLIFLNPISRISPFLFGLGAPLWCPIKFNPTMKKLIGLFSFLIGLSVALIIWFPHFVKKFETINSYIDGVYAALHRSAWALAIIALAYVFENLNEGNVIRVFASWKLFYPMSKLVFLVFLLSEPVALSLFASLHRPINATLFSIILTTVGTFVCSYILAVIVEVIITLPIRHLFDFICPIETPPDTVLSGTQNRGSIPSVDREIEPFIRKNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXV3</accession>
    <name>A0A914YXV3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arylamine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.5" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YXV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4931.t1">
        <property type="protein sequence ID" value="PSU_v2.g4931.t1"/>
        <property type="gene ID" value="PSU_v2.g4931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004060">
        <property type="term" value="F:arylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4931.t1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35522" checksum="A7B03BC65D45E948" modified="2023-02-22" version="1">MENFVEEYLERLEIDFPKNNADKEYLNALHIAHLTHIPFETFDLIDLKELNISPNYIFYRLIQQKRGGVCFQLNGSFERLLKSLKYNVQMIPCCVYGIKSKAYGSCNDHLALLITLEDGTKLLCDVGFSRNFLTPLIFKVDCVQFAKSGFFRLTKTDEYFVLERGYLGIEQNDNKVVLPSLSKLETCIVDIDPKQFKWTPSYRFTVDFDKLSTKLEDFEGASVHVIHSPDCILNQLSLCRIEAFQPPSFIGGFGIVGNDFVEYSINENGIEAKKYFPLSNDDDNNELKKILKEKFNLQIERKLSLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXY6</accession>
    <name>A0A914YXY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4502.t1">
        <property type="protein sequence ID" value="PSU_v2.g4502.t1"/>
        <property type="gene ID" value="PSU_v2.g4502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4502.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8698" checksum="2EEB90BDC86188DF" modified="2023-02-22" version="1">MESVIPMAPADVQMVGMEKIAINVFHYQVVMEVAQTRMNVFALQVLKGNIVMKVSALFQKWIIANNMMIVTEISEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYD6</accession>
    <name>A0A914YYD6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YYD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3072.t1">
        <property type="protein sequence ID" value="PSU_v2.g3072.t1"/>
        <property type="gene ID" value="PSU_v2.g3072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3072.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22120" checksum="77606D42B7782CF0" modified="2023-02-22" version="1">MSPPATSQFGTKAIHAGQDPEKWGSNEVIPPISLSTTFKQTHPGVYKAHNYSRISNSSRDVLQELLATLENAKYCHTFGSGLASVMSTINYLKTGDHIICADNVYGGTYEYLTTVSVPQHGLTVDFIDFTNLDNLKTALKSETKMIWFESPSNPLLKLVDISEAVKIAKSYNKDILVVTDNTFMSPYFQNPLSFGVDIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ21</accession>
    <name>A0A914YZ21_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ21"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5195.t1">
        <property type="protein sequence ID" value="PSU_v2.g5195.t1"/>
        <property type="gene ID" value="PSU_v2.g5195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5195.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35731" checksum="6364FF7E3E92EA7E" modified="2023-02-22" version="1">MQFNSEERWTKAMKLLLMDLKRLVALAPHTVVQKVPTSSKDHEEEGPKPVNDTNAAEASFTPSSTTCQPFEILWPRLPSLSRPSARTTASTEIAHKISKKKKEQRWNSAFFYFSLLLTQQIFIQPIKNHLINSTDNFKSGIKLQEDSTTTTEYFSSSFKELNTKMYSYGETEQYNDGSHQLFDPAIGKFQMGQNNFFAPRFRWRNDAELASYAWNRQEKAQVNMMMTENRVPSYGPTTSDKASCGSSCAPRDPSLLDYDAIDVSWRNDIEREKSRPSEYTSRDMYDAQFERDLQVLHEKGYIATQSTSGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZG6</accession>
    <name>A0A914YZG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZG6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3428.t1">
        <property type="protein sequence ID" value="PSU_v2.g3428.t1"/>
        <property type="gene ID" value="PSU_v2.g3428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3428.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15585" checksum="039F698109CE4E98" modified="2023-02-22" version="1">MMLWLPLVLLEYFTTALIILDFCIFDAKHNPDFNLIKMIFAAYLSILSSMILFISKKRKHVKRQNTVYSAFSVASTPLSQCSSRLTASRIHNMSHLSDILSQTSKSESVPDLVEEYKNAPEILENHTVNRLNDLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZU3</accession>
    <name>A0A914YZU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZU3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5142.t1">
        <property type="protein sequence ID" value="PSU_v2.g5142.t1"/>
        <property type="gene ID" value="PSU_v2.g5142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF533">
        <property type="entry name" value="TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5142.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="46901" checksum="879AF490BC773E35" modified="2023-02-22" version="1">MSSSLILNADAESADNTFDYGFVPAPRNSSDNPIEAEDLIMYKSRECQNGTFQFYALVNGFRNGHVVAEHVGNALVQRIFFNDDIGNLDTSDSDTARHVDKVITSAVKDAFIKTDSDYFNAKIDSVLAERLQQQLVANKEMTYDSFEQLSETEHKIAGGAVAILAMIINKRLYIANCGNSVAFLTKIGKDPDELHAFQASELHESHEIKEIDRLQRAGVDPMNIDGPSRCFGDYFRKTGFHENPSIKTALAEPVCVEPAVAGGLEVDENYCFLLLLSPSLGQAILKIETDRKVSEYIIQLFVNHIREEGSLKGAAQAVLESIHQELQVKIEQGHLRPLETSLSLVVVPLNDDIVELLRESEKSIHAQSHGDNTVDSYVDFSEYFVDTPEMQDKRNDIEAKIASIKQLYKENKKLRPISED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z055</accession>
    <name>A0A914Z055_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z055"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5728.t1">
        <property type="protein sequence ID" value="PSU_v2.g5728.t1"/>
        <property type="gene ID" value="PSU_v2.g5728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF20">
        <property type="entry name" value="BESTROPHIN HOMOLOG 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5728.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34442" checksum="C9CB0F051C0DF130" modified="2023-02-22" version="1">MVLTQILILRDISLQVRKRFPTIETVMEAGFLTNRERDAIDAVDDQYTRYWVPLKWVYQHVRQARRDNIISSDTFYNRITLEVQIFQQGLANLLKYDWVPVPLIYPQLISLSVRIYFLLCLISRQFLKDSPIDIWVPILTMIQFIVYFGWMKVGEVLLNPLGDDDDDIECNHIIDRNLITGFKLVESTVAPKMEKDVWWNKNQIIPLYTVKASERSFSPLIGSAANVSLLKKGTTTIEMKPHKNEFRIMSDTEKKFFTKRVHIKPLSTKIAIAKASDDEKRVSMLEVEEENEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z172</accession>
    <name>A0A914Z172_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasminogen receptor (KT)</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z172"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6113.t1">
        <property type="protein sequence ID" value="PSU_v2.g6113.t1"/>
        <property type="gene ID" value="PSU_v2.g6113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019319">
        <property type="entry name" value="Plg-R(KT)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411:SF6">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10166">
        <property type="entry name" value="DUF2368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6113.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13347" checksum="914CC777A178EECF" modified="2023-02-22" version="1">MERQIALKNLQFETETSCKTKSQESFIWESLAAMTTIFGTIFQAHLTKNRAFALPIVPITMYIGYRWDEIYGTTSEKIKADAEKLYKQKRDLFKPVGGPITLEELDRRRMAWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1S6</accession>
    <name>A0A914Z1S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1S6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5850.t1">
        <property type="protein sequence ID" value="PSU_v2.g5850.t1"/>
        <property type="gene ID" value="PSU_v2.g5850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5850.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30225" checksum="182099F9465EB6F3" modified="2023-02-22" version="1">MPLDGFFIDYRPVDEFSRDEFDIKNFGFADLVAFFPGWKFELYANDIAIILLPTEINDIEPVLLAKNFIEGENDMGVNVGYGDMDIDMDIENISKTLLKIDIPILPFEECIQSNVYSVMCAGTSEKRSDHGDSGGPLFFNASDGKEYQIGIANGMALKSGNFPLPWDVPDYVAYIRISAYCIWIEQTTKGEAKCVEIGGMSTSNQNPQVPENGDEPDVPPNTNKLNDTTAKAQIAGITEVQKSDENNGAVSKNCILLTLFFSFILNFFELVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2I8</accession>
    <name>A0A914Z2I8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2I8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6926.t1">
        <property type="protein sequence ID" value="PSU_v2.g6926.t1"/>
        <property type="gene ID" value="PSU_v2.g6926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6926.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16836" checksum="D1F1E6F8E6FDB0BD" modified="2023-02-22" version="1">MATVEKPAPGPLPVQVFGRKKYATAVAYAKKGKGIIKVNGRPLEHLQPEILRLKLQEPLLIVGKERFANLDIKIRVTGGGFVSQIYAVRQAMAKALVAFYHKNVDEQSRRELKEQLAEYDRTLLVADPRSTESKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z328</accession>
    <name>A0A914Z328_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z328"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6298.t1">
        <property type="protein sequence ID" value="PSU_v2.g6298.t1"/>
        <property type="gene ID" value="PSU_v2.g6298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055230">
        <property type="entry name" value="PH_Tiam1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23014">
        <property type="entry name" value="PH_Tiam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="140"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6298.t1"/>
        </source>
    </evidence>
    <sequence length="494" mass="56575" checksum="C4D528E2A37AA217" modified="2023-02-22" version="1">MTTSTSSSSGIDLSADPRLPGNAIAASKHYMETLYSLKYMLIFRIASLKGFMPNSNFSEMIYPTELRARVSSTHLPNYVHLYCCLHTQFSIKKQLKEISDSSQFLRVIETPIKSSPVTTPQEPKLDASKDVETRRIIDEKLLKSIIELVQTEETFVKDLEKLMEQYVIPGQMKYLECTEKLIKTHSIFLSSLQDASGDLLTASSSQSLEYTQIKDAVMRISALFINKCNKFKIYSEYSAAYLRFQHLQKADEKLKNKLEELNASGQHKESVQSLLIKPIQRVLKYPLFLEQIKDFCTKDSMEQRQCIQALNRMQTLATYVNEMQRIHEEYGSELERLAKLPELEEKNLWMDLRDLFMFAHLKWILPGEKKYTDCVAFVFMSLVLVLGPVSVGKKKQPRLHKIFPILEIEANELDSEVTSLASTSTNDSSQHYFTINHLGPSQSEIIYPISCCHVDIKTHFIKSVKKALRVYLKQKPRPISGSSQSDWGYSSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z355</accession>
    <name>A0A914Z355_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z355"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6326.t1">
        <property type="protein sequence ID" value="PSU_v2.g6326.t1"/>
        <property type="gene ID" value="PSU_v2.g6326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025615">
        <property type="entry name" value="TILa_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12714">
        <property type="entry name" value="TILa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="488"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="5">
        <location>
            <begin position="524"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6326.t1"/>
        </source>
    </evidence>
    <sequence length="786" mass="86629" checksum="140EBD654DD315A5" modified="2023-02-22" version="1">MCNILNPQITKFINLSKAELAATATKIPALTTAIPKTTLPVTPTTKSTKTLTTTTSLQPQAIMMTNTASFQQLAGARLVRQQVLSTTTAPFTACPICNTGPNPCKNNGTLIITGPDTVSHITEITLKTQKHEFRVDANTNYYIDGIITYYPNYWPSETDPRIVATKPGARVIIQDNLSGAVITFANGYLCVEVPLNEMFYGNDTMCGIWGNINDVCGDDIEDKNGNQFIQPANGCRIGTNSEAFHFMDSWVVDSTVNNCVEAEVLTNITTTAPCDIQAAQNQCDLIRQAINGQGPFAACTVMGHDAIDKTFHDCAFDICHSFQLCDTLNAFALLCNNFPFTNIDNWRDIANCPYTCPPNSHFSMKTPKCQNSCSDPNYSNSSNCQDGYEQGCTCDANYYFDSNGEHTGFAFACRALNDCGCVDGNGNYYPAHSKWLDANCTIERECNDGNLTSNPVTCSTDAQCNIVDGFSTCQCDAGYSGDGYICNDIDECQDSNMCSSHGNCTNFPATYKCTCYSPFSGLQCENYTPSRHCADLQIYHKITHSGAYNISLAANYTMQVTNADLTWTEVFCDMESNGGGWTLMSHESGSAATKKINCGKTFREYVRGFGDPISLTVWLGLENVHAITAATPTSLRIIIEQCAAEFAPYQKDECTYPYFSVSDSNSQYAIFLNNSCIGPANGRNDDWITWDRNQMGPKFYAFDEDTPYNCSNTYLQTGWWFNYVNNGDLCGAANLNGIRYACNENEYQYTGKHLSWGNSPVNDAYMYLRPRDFPNYDSTTTSPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z403</accession>
    <name>A0A914Z403_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Magnesium chelatase ChlI-like catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z403"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6732.t1">
        <property type="protein sequence ID" value="PSU_v2.g6732.t1"/>
        <property type="gene ID" value="PSU_v2.g6732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007365">
        <property type="entry name" value="PRK09862.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00368">
        <property type="entry name" value="YifB family Mg chelatase-like AAA ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="COMPETENCE PROTEIN COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="MAGNESIUM-CHELATASE SUBUNIT CHLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13541">
        <property type="entry name" value="ChlI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Magnesium chelatase ChlI-like catalytic" evidence="2">
        <location>
            <begin position="196"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6732.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="29336" checksum="50A95BEFE30B403D" modified="2023-02-22" version="1">MVTQGGLMSLSIVHTRAALGVNAPPITVEVHISKGLPGLTMVGLPETTVKEARDRVRSAIINSGYEYPAKKITINLAPADLPKEGGRYDLPIAIALLAASEQLTANKLDEYELVGELALTGALRGVPGAISSATEAIKSGRKIIVAKDNEDEVGLINGEGCLIADHLQAVCAFLEGKHALERPKPTDAVSRALQHDLSDVIGQEQGKRGLEITAAGGHNLLLIGPPGTGKTMLASRINGLLPDLSNEEALESAAILSLVNAESVKNNGGSARSAHLITVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z427</accession>
    <name>A0A914Z427_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z427"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6757.t1">
        <property type="protein sequence ID" value="PSU_v2.g6757.t1"/>
        <property type="gene ID" value="PSU_v2.g6757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="11">
        <location>
            <begin position="162"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="247"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="806"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="912"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="963"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="806"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="837"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="916"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="999"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1021"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6757.t1"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116410" checksum="6CE4D33782D22481" modified="2023-02-22" version="1">MQKFFFYSSTVSTLSSSTSTSEQGGDSSASSSGVATMSSNDHIPCSNVNGANLLTSGSQSSSSNPSPTLVPLHLDTFTKKNSGFGIGFFTNRSISQNEKNSECNKALEPPGISQRCSSRASSGKNSPLPQLTSPQPASVFSAESAKEMICVPLRTIVSQNRRRFQSDGFNLDLTYITDRIIAMGYPADTAESLYRNNMKHIVKFLEKFHPDKYKVFNLRGQYAYDEKNFHYRVVSYEMKDHHPPRLELMAPFCREVHDHLEKDPTNVVAVHCKAGKGRTGVMICAYLYYIKFFENPRQIMDYYSIVRTHNNKGVTIPSQRRYVYYFSHLRDKQLNYLPLKIELVGIYIERPPKTRALLGKGSINLRVANGDIDVFHGAELSLSADEYDKEDEMWQKYPNMIGEDSYDPYNPQPGKNCISRRCYGWTVPSNARVFLEGDIRVDVVKSPPLSFLPRKPDKIGHIWFNTMFTCPSFCGGAYMHGDEAFPYPDDGATIVSKVTKQKSSTSDSPIDNIPKSSSVSEHRVHSASSFSASVPNSPPCHKLNFSLGMPNRASAPDTEPIDSPPAVISSSTRSGSRTPSIGQHKSSSGGLKLNGVAKKLAEALEPKKAIRHSDRSSAAQDINLKCERWSSQDGGIAVKRNEIMDATKPSRASLDCVTDYDNNENEAIIVRKPPGLDDHCPEESLNHIYPHGNAPRHNIEEMLRVAYRKNLIKDGYNARRLSVPKEGNLMPKAENSSSRPLVGGPFCLMRKPDEHVSTYPVMEIDRAYKNKEIDCGFKIHIVTRCLNTSTPSDIKLAESFINVTRKKQEEKDSKKHETMKGKKYAEEAKRFKGTGTVSSESDQNDDNSSVENADIKNDPHLKKFFFRQRVTSASKHPNYRYNCSLYKAETIGGTRVAIKPDRPTIEENLNELRNDSFGSNLDTQNSSPQSDTTIIPAVHGRSATISTTGEEASKQLEVAAPVKPTLRTRSARSATVDKSIKKQSMASTTSNQTDDIHPSDCSWTSSSTSSSCRSLDEAENNDANSSNSDSATIRRPAESFSDDKRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4I6</accession>
    <name>A0A914Z4I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4I6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7603.t1">
        <property type="protein sequence ID" value="PSU_v2.g7603.t1"/>
        <property type="gene ID" value="PSU_v2.g7603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7603.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20891" checksum="62A94F4122EF62CE" modified="2023-02-22" version="1">MVGVTTFYCEDYCYKLNVDVTKLLSSKKTVDPRFAPSDGFPSSASSNDRNAPQKKNVATTPNHNRVVLGDVYGQERLSERRRLANRYEPDAPTGSSARARVDENAYEGFDVTQNGNMVYQTPASRKDMGNICNAPKKPMQSRKRFPDRDACEEELLPKKLNFEDLEPVELEHAELEHAEQPWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5N9</accession>
    <name>A0A914Z5N9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5N9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7218.t1">
        <property type="protein sequence ID" value="PSU_v2.g7218.t1"/>
        <property type="gene ID" value="PSU_v2.g7218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038114969" evidence="1">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7218.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15522" checksum="D438882CD95F0E2C" modified="2023-02-22" version="1">MEYCKFVFIIILLFLGTGGQRFHRHLLNDTQNEFGLGNIDFDNSDKLASEGSYQLGELLSGDDNFDINTVSDAPLEFELLHGDLKFQMCTYNCDDNVVILCFDSDEPNTVQRSNQCGPNQCTFQAGFVKDSDGKNMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6M6</accession>
    <name>A0A914Z6M6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6M6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7574.t1">
        <property type="protein sequence ID" value="PSU_v2.g7574.t1"/>
        <property type="gene ID" value="PSU_v2.g7574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7574.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10495" checksum="69B8BA69126FAA77" modified="2023-02-22" version="1">MAKMEALTKEQIKEVMREARLMRGFDHPNIVKFYGVAAGTEPLMVLMELVDCGALDSYISKNPNLEPIKRVEIVLFIVILLHEIVFMEMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z858</accession>
    <name>A0A914Z858_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z858"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8086.t1">
        <property type="protein sequence ID" value="PSU_v2.g8086.t1"/>
        <property type="gene ID" value="PSU_v2.g8086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23342">
        <property type="entry name" value="beta-trefoil_FSCN_ZgPorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052883">
        <property type="entry name" value="Hisactophilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33351">
        <property type="entry name" value="HISACTOPHILIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33351:SF1">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8086.t1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38301" checksum="23272B8CDADB6ECC" modified="2023-02-22" version="1">MHQIQTGRGTSFIINNEFRDVRLSINDKVKELQNVINLIKEYKVRHPESDLSELKLPHAVDEIKTFLSTCAQYDPKLKHAFIRGIHGKFLSSQNGTRSMTAGDRPVPLGWEVFAIEERENGKVAIKSCGKYVSSQNSDRDFRCNSVDVGAKELFEMIEHENGIYSFKGSNGKYISSSDKEKAVTCNSADINNDEKFNIEWVGDLTDEINISWAYYHKYFKRLCIKLNTAVEEKKKINPENYFINNEIEVYNNGANNPYFTHHQQQIFSQKDFKEAIKEADNKIREVKWETLNERNYLLGLVWGEKHKNEQITEMVNALSPVFAYLGVNANIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z865</accession>
    <name>A0A914Z865_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z865"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6444.t1">
        <property type="protein sequence ID" value="PSU_v2.g6444.t1"/>
        <property type="gene ID" value="PSU_v2.g6444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037725473" evidence="1">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6444.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12658" checksum="AAE6466113014186" modified="2023-02-22" version="1">MKLIFVVALICLSSTAFAVTLNQRPDGITDSFKCILCQDVCKDTESWEGQEEQNHEAGQIAKCEKLLGQSTIAKIICEDFLKNDLDAIIQHMEDPNTEKSDCKKACQDIKMCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAH2</accession>
    <name>A0A914ZAH2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAH2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9322.t1">
        <property type="protein sequence ID" value="PSU_v2.g9322.t1"/>
        <property type="gene ID" value="PSU_v2.g9322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9322.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14180" checksum="D0DDC48BF0902D3C" modified="2023-02-22" version="1">MSTKPADLEDEVAEAEASKKVTGFDAKAIEKASTQMEDTSQEERDDLKDADVNGLSVSAQQEKPQIKIKRDDINYFVENFGIDKVAAEALLTEGGGDLYKTVLTYIEYDKMPEPPTFEEVSKSSSQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDC9</accession>
    <name>A0A914ZDC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDC9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9949.t1">
        <property type="protein sequence ID" value="PSU_v2.g9949.t1"/>
        <property type="gene ID" value="PSU_v2.g9949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9949.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14404" checksum="C8E1C0E428545407" modified="2023-02-22" version="1">MHKGRFVEAGTHHELLERKGGVYAKLVAAQELHNLNIDKKDDGEHVEEELLSPDQPNAALTIASKTVRESIRESFMRDFLPSDHLGDAQTEAYDVSSTDLIALHQSGQLRRMVNSCSRKAAAVAAVAVAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDS0</accession>
    <name>A0A914ZDS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDS0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8419.t1">
        <property type="protein sequence ID" value="PSU_v2.g8419.t1"/>
        <property type="gene ID" value="PSU_v2.g8419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038047197" evidence="7">
        <location>
            <begin position="20"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="266"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="552"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="700"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8419.t1"/>
        </source>
    </evidence>
    <sequence length="748" mass="83176" checksum="9CA40718C1AC1F46" modified="2023-02-22" version="1">MIKWLICLLAVGAFTYGNAFRSGTGQQMKPKLNCTEVGNGNFVYGCSKVFWMCSNGILYSQQCHSELFFDPVSNACEREENIELCNTQNSTDLHKPSKATEAFNCKGKVDSAYELAPCLYRFAHCKNGFVFYEGCPTGTVYDDNKKYCDWPANVAGCQDKERLSSRSPLDGETAAASPGYGPDDVPPPSIIHQQSAYGRQFKLGSSPVGASEQNDTLQHSSPTHSPPIQQQQPVGPPHTEHRQKQPQPPQQKQQQKLSEQLSLKNEFDCTGKKDGTYPTPQNACATFFYKCSLNETYKYNCPHGLYFSTQKVHCEFLSKTPECNGHVLPYPNGPLAAPPANYTKIPVQASPYPPSNSNQQQSGASNINAKPALKVDFNCRDKADGFYAIGKCRNDYIRCVHKTSYLQECPKNFVFEADILTVPPQSNGQQQVQSSLQLPQQPVVPAPPSQSYTFKQAQQRAINQTQNSYIHAPSTAVSSQSKQQDMPQKSSSSYDPQQPLYSQQQQSEGYLQNHRYTEVKPKPQSERIYAQPKSQTEGSHSQQTPPVAQIRDTFCQDKGLVHGYYSSGCSSYYFACVPRNTIKVPCPANLFYDSETEKCDYKTNVPACGGSRPSQQQPQSPPAYGQSNTQASLVVAHQQENQPSQQQQNSSVVTQPRHQSASPQLQQLYDDHNSQQDIIHKSANLRSFIQNSEVYQPIQSSIVQQQPAAPTPAPAWVPYSGQQQIRQPEIQRNQMPAQQPASNPAPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFC1</accession>
    <name>A0A914ZFC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZFC1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8975.t1">
        <property type="protein sequence ID" value="PSU_v2.g8975.t1"/>
        <property type="gene ID" value="PSU_v2.g8975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8975.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27486" checksum="3EC12E2090C8299D" modified="2023-02-22" version="1">MKKIVNPNWIPKNGKISLRIEIIDPSDLELITYFYNDHYVNHGNLWKSIKITSKECHPLSFDIVSLAIEKPVSLAAFDGNQLVAVQLNRVQSPDEFSKLFDGQLHHENPKLVIKDDYAKDIKNGPYNLQANRIYVILQETLKQAGKFLPKTTKNLGYFKAASVHPDYQKFGLGSYLGIESLKLFHVHHCEYIMGFTSVDATYKFSKKLGMKECFELPYSKYKKIQSLFLVNYQKREDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQC8</accession>
    <name>A0A914XQC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XQC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10220.t1">
        <property type="protein sequence ID" value="PSU_v2.g10220.t1"/>
        <property type="gene ID" value="PSU_v2.g10220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051098">
        <property type="entry name" value="NeuroDiff_E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793:SF13">
        <property type="entry name" value="PROTEIN DAUGHTERLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="165"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10220.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="26137" checksum="8E9161336AE4296A" modified="2023-02-22" version="1">MPQNDGFSTGGGINGTLPNPELYLPLGSMTVNSTSGPNSAQYAPPSLPSNNLGTLPPLLPQQQQQQQVVAPAEVVLPPQLQQLQQLQQIQQQQPTIPINGGQTSPDFTSTTPRLCSSVGTSNPTSGRVTGGGGGGGGGGGSRGRRSRSTFKDSDDDAKSDDRDCERRTANNTRERIRVRDINSAFKELGKMCTQYMPNSAEKGQTKLGILHQAVKVISDLEEQVRQRNLNPRTACMRRREQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS67</accession>
    <name>A0A914XS67_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methionine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XS67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10829.t1">
        <property type="protein sequence ID" value="PSU_v2.g10829.t1"/>
        <property type="gene ID" value="PSU_v2.g10829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="39"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10829.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40085" checksum="65A346E4C260FA40" modified="2023-02-22" version="1">MADYLSSWKSEPTYFDESVKKKSNGTNDYRLPQEGKRNVLITAALPYVNNVPHLGNIIGCVLSGDVFSRYCKIVGHNSIYISGTDEYGTATEMKALKEGKTSQEICEQYYHLHKQIYEWFNIEFDNFGRTSTENQTEIAQDIFKKLHANGYTSVASLDQLHCGKCDKFLADRFVSGTCPNCKYEDARGDQCDKCGKLIDAVDLIDPKCHICSETPVVKSSNHVFLDLKQLSPKVEEFINQVTSAENSHWSANAIAISKSWIKSGLEKRCITRDLKWGTPVPLEGFEDKVFYVWYDAPIGYLSITKTLLGDNWTKWWKNPENVELYQFIGKDNVAFHAVMFPSCELGTGDKYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTT2</accession>
    <name>A0A914XTT2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTT2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10672.t1">
        <property type="protein sequence ID" value="PSU_v2.g10672.t1"/>
        <property type="gene ID" value="PSU_v2.g10672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10672.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13148" checksum="1EA8B58C4B830EB9" modified="2023-02-22" version="1">MLSLTEQHSAASPLRDEFIDRAAFDDWFARYRGRLQQDEVSDSERQQLMQSVNPALVLRNWLAQRAIEAAEKGDMTELHRLHEALRNPFSDRDDDYVSRPPDWGKRLEVSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUZ0</accession>
    <name>A0A914XUZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10359.t1">
        <property type="protein sequence ID" value="PSU_v2.g10359.t1"/>
        <property type="gene ID" value="PSU_v2.g10359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="124"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10359.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="30975" checksum="4875E95254E8D985" modified="2023-02-22" version="1">MHRDSEASDVIGQDDGNILETVKAPSNSSIALSPRRSSSTSSSDIKRCPSNYYCVAVFDLPKQPNLYQGFCCPIPAPDIPVCPVGIPHVSSSPPDYGCAECPFDHFCHKDSIATHKEICCPKPCVSPDDVYVDGQCYSIAYHGDSCHVPEQCIGKFAGSTKTGEEESIHEEIHEMECRKGICECPKGWLIDNGLCKRVECSVGLKGEPIVNSLGGILKCHRSSDCSQGSMCDPFSKVCCKGFNKCPASFVETGEMCKEEKCRNPNDICIVPKNSKSKICCRKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVX1</accession>
    <name>A0A914XVX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1138.t1">
        <property type="protein sequence ID" value="PSU_v2.g1138.t1"/>
        <property type="gene ID" value="PSU_v2.g1138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1138.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9650" checksum="4EA5D5FB2116F52D" modified="2023-02-22" version="1">MTGEEDHDEDALRKELTKHVRTEIGPIATPDMIQFAPGLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVDDLIEHRQNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW34</accession>
    <name>A0A914XW34_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW34"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11182.t1">
        <property type="protein sequence ID" value="PSU_v2.g11182.t1"/>
        <property type="gene ID" value="PSU_v2.g11182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11182.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11934" checksum="488A6D33023239D2" modified="2023-02-22" version="1">MPNVRWHIKCYPEDPRDNGYIGVYLNIQSETEISYIIDNVVNKFIRGHEKRLQNLRTIKNLAKKTTIICGNDEYRLELIQGYTGYSANINLIVQVRATFTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY89</accession>
    <name>A0A914XY89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY89"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10674.t1">
        <property type="protein sequence ID" value="PSU_v2.g10674.t1"/>
        <property type="gene ID" value="PSU_v2.g10674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003742">
        <property type="entry name" value="PRK05339.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PYRUVATE, PHOSPHATE DIKINASE REGULATORY PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756:SF3">
        <property type="entry name" value="PYRUVATE, PHOSPHATE DIKINASE REGULATORY PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10674.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19785" checksum="9BB37FC13E4F22CA" modified="2023-02-22" version="1">MKLDPTPIAHRTHGLNPNNLNKYDARIAAIDYTLAHDDGISLRNLDQAQVILLGVSRCGKTPTSLYLAMQFGIRAANYPFIADDMDNLVLPASLKPLQHKLFGLTIDPERLAAIREERRENSRYASLRQCRMEVAEVEALYRKNQIPWINGTNYSVEEIATKILDIMGLSRRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYX3</accession>
    <name>A0A914XYX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13142.t1">
        <property type="protein sequence ID" value="PSU_v2.g13142.t1"/>
        <property type="gene ID" value="PSU_v2.g13142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13142.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32832" checksum="F5BBE2A4F23E7F5A" modified="2023-02-22" version="1">MKKSQLSFLNRKRNVDVIKDMETDPLADWKNGFLLTPKRRSLSQNESSNFNNSTPAPLATLDEDDGECKENEHNDEEKIDYEASTSRKTPDTPRIRQRMRRSLSVPLVNKSRGSSTSDDGNKYTNTTCDSPPPPSGMCLNRIDSRRHVFERKRVFIKAVCYICYSNIRFGIEAVKCQLCKSVSHQHCSRRAPIPCIPWAPPPKATNGRLRLGDYCADGVVPKLPHLIIRCVQYLNTEKYSRGLYTNYDYSTEADFLLKLVQEKIPPELKGYGPQATAHCVIKFLSDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZE8</accession>
    <name>A0A914XZE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZE8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12332.t1">
        <property type="protein sequence ID" value="PSU_v2.g12332.t1"/>
        <property type="gene ID" value="PSU_v2.g12332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12332.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8106" checksum="5ED7B807C161FAE0" modified="2023-02-22" version="1">MGSLTSGDTPSLHKFIKYNRHMGIKSPIVKKLHSDYLMTPIIEKTTSHEALDGVKVNKIWHHLISKILKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZH1</accession>
    <name>A0A914XZH1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XZH1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11928.t1">
        <property type="protein sequence ID" value="PSU_v2.g11928.t1"/>
        <property type="gene ID" value="PSU_v2.g11928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="17"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11928.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38338" checksum="213DA2E4B9EE2A9E" modified="2023-02-22" version="1">MEKIPKKQKAQVITEYGLDLKFKEIDVPIPKSDEVLVHLLYSGVCHTDICFMKNSLSQYQMPLPMVAGHEGAGVVVAIGDDVKSFNIGDKVGAKMLNRICGYCENCHISGRDNKCENRVDLMVHKFGTFQQYITIAEGDTVRLPQHVDLKIAAPLVCAGVTVYKGLKETGCIAGEIVALHGASGGLGSFAIQFAKNAGFEVIAIDLGEEKGKHCKNLGADHYLDASKSDLTKRIHEITNGRGPHGVVVIANDIKAFEQAFEYVRDYGTIVCLGVPDKNEFHADLMNILNRHLTIKGTILGNRTDYKEAVALLANGKIDIPVEVRGLSELGEILDRIHKGEIMGRVVLDTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y035</accession>
    <name>A0A914Y035_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7596 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y035"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12142.t1">
        <property type="protein sequence ID" value="PSU_v2.g12142.t1"/>
        <property type="gene ID" value="PSU_v2.g12142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056017">
        <property type="entry name" value="DUF7596"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24524">
        <property type="entry name" value="DUF7596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7596" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12142.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40517" checksum="A030E0296D757D62" modified="2023-02-22" version="1">MLATTEIRNLLQNTKIERVLGGNLLPANNNSSFLSLEDVYTVTVVEDNPKGSIPIAFGLFNRCSPNQVYCAVITLKKGYETKFVALERVKNEMGVDAEDVRRHACYRISRVEEKEVDTGSLPQYYSAFAVREVYPLHQCVVDALIDNTIGHKNMDMKRNITVDLYDTHSGRFAEVRDELWRDRDGFIVGDRLRYAEIEISRASLLNTLQKNKKDETITYETLNSKTSAAFLEYDSEICVSDRSEYLEYLFSLTGIKGTVALDKSKRPAGYVLSLGNHILQCYGDSPEIANATLAKHVSQMIEPALSMFIRYDKNWASNELVAAASASRRVRRFHSRIVPTQVKWNKVFALNMGTHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1D8</accession>
    <name>A0A914Y1D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1D8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13269.t1">
        <property type="protein sequence ID" value="PSU_v2.g13269.t1"/>
        <property type="gene ID" value="PSU_v2.g13269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13269.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27485" checksum="D1B5B09C532EEBAE" modified="2023-02-22" version="1">MILFCVRTIQTCFSDKITDAKKDKKCFFDHDLLQSKGLAWSSRGPLKNCPLCVHFAKISIDAIIGADQSVARCVRKIIYPAIGREGGECLKNNITDFSDKEIPEIPDFEIESMKNPNEALESISIEILRNFRLAKCRTRNPEWAENTEKCLKNPKLENFMPKHCKTVDTCKKEVSKNCTKKLEEIEGPTCGCFKITGEEIKKKLQSVGADLKQLYSARPHDQKLGAASRPEIDKCVETIRNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2W8</accession>
    <name>A0A914Y2W8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2W8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13123.t1">
        <property type="protein sequence ID" value="PSU_v2.g13123.t1"/>
        <property type="gene ID" value="PSU_v2.g13123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13123.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26590" checksum="F1D6FAD8DF43AE90" modified="2023-02-22" version="1">MPGISPTNHGLNRRRPTRRFRRNNKNAVVNNSDHDYVRITWMKLIEGKAKDVKKTNSEKIKEMVLQSENVVEVFDLMIKEGRINITKAEVPKKKSNGIQNSTELLFVPKFLKALQCKGFKKQEIYIKNPQNWYEKMSKYFTSQHTVALVVPDHWDADSAVEIITQMGNIVKCLKVLLPSYRQLLCQNLLAQNITVAICDTIEEYKNAIKNMTENDFHEDNYPSELKFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y314</accession>
    <name>A0A914Y314_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y314"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12163.t1">
        <property type="protein sequence ID" value="PSU_v2.g12163.t1"/>
        <property type="gene ID" value="PSU_v2.g12163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12163.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36025" checksum="AC8C48265473C3CC" modified="2023-02-22" version="1">MPSLSVKSIVNLITAGTKSVDRAIQSTRRGSNKIRPKKSSVADVKIKPSKVTIPLPDECWNLICDNLSSFDQIKLRRVNKQLHGIVEKRLESQIYLDIVKCDTDEILLDEQNQKIIRVYDFHKHRKNNVLLHMSQRNTALIVDDRWSSRDVYCTFGAIQFFSKYAHCITMDVQIAELLIVGCSTLKLSRWHSFECYVNAVGMIAGDELHMKLSKSPPSKSALFSNAKEITIRALITDLSHLSRIPDYSVAVEALFDSNKIELFRINIIDNSTQCRSELGSNVRLIRRPHKHLHIFKKWLNTNELREKYVQQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4J8</accession>
    <name>A0A914Y4J8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4J8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15119.t1">
        <property type="protein sequence ID" value="PSU_v2.g15119.t1"/>
        <property type="gene ID" value="PSU_v2.g15119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15119.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11861" checksum="CA393CC8547F626E" modified="2023-02-22" version="1">MSYDNGEALGDLSTNIEEPIDFIRFALNEHVMVKMRTDRHLTGILQSFDQHLNMVLSDVVETITTTETDPDSTEEIVKTTTREIPLLFIRGDSVVLVSTPNRNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5M7</accession>
    <name>A0A914Y5M7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5M7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14741.t1">
        <property type="protein sequence ID" value="PSU_v2.g14741.t1"/>
        <property type="gene ID" value="PSU_v2.g14741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14741.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26813" checksum="62D9C68955B0356B" modified="2023-02-22" version="1">MADIDDLVTQLAALTAALNTAHTAPQAPHIDALAAAIAQLQQQQQAPTPTPSACVLPVFVLNAANPHFTKSWFAQAEMVLQLHTHNDADKVRMVVSSLDTSTFDKVRRALLPDIITELQDFAKLKKEMIKLFDAEDSLFARRFAALQVEWSGPEKESIREYEARIRECMGSFDMDNFGENEMASLIYVIGMKARALEPLRTMCVDALRKNPKIPLKELSEMVAASILTRQEQQEKSSTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y607</accession>
    <name>A0A914Y607_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y607"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13100.t1">
        <property type="protein sequence ID" value="PSU_v2.g13100.t1"/>
        <property type="gene ID" value="PSU_v2.g13100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11882">
        <property type="entry name" value="SH3_GRAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000006">
        <property type="entry name" value="Rho GTPase activating protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000055">
        <property type="entry name" value="rho GTPase-activating protein 26 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047234">
        <property type="entry name" value="GRAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552">
        <property type="entry name" value="OLIGOPHRENIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN GRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="62"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="526"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13100.t1"/>
        </source>
    </evidence>
    <sequence length="588" mass="63420" checksum="F2EE4C39B18D28AF" modified="2023-02-22" version="1">MSNNLFLTKSRSASWSDASAILSAAAADGQPVGSTYNIARGLLTIYNGSAFLPAFVVDDCYAMLDDTGFEFVRMCLKAIEEKGLREQGLYRNCGVTSKVQRLMQLALDKRKGTLEKLNLQDDSEWETKTISSAVKTFLRNLPEPLMTFELHNLFINAAKLDDIQQRVNHIHYYVYKLPESHRKMLEIIIRHLRIVADNCNENLMTVGNLGVCFGPTLLRPQEETMAAIMDIKFCNVVVEVLISNCQTIFNTPSPMHINLPCPPKPAHNILASSNGAQTTPSKNSGGGTTLPDGYVQNSARIFSSSGSTTSSQSPGSGTQSSTASSAAAAAMIRQRQPPPPPKGVMPQYDKVPYESRSSDDLTVAVPNASSSSTSMYPALAAGSQNNRYQPPRIIEGGISTRVPSNSDDRIGTSSSSSGIGGASNTLTRNKYSATYAQPYNPQACDKLQKRHSGGNLMSNSVHANLAGHTQQSSTGGISVNGGDAVNQAGPSRAAPQPPTFNTLQPIHTTRIPPQYSSLINPEVQCQPSRRVKTLYSCTAGHETELSFEPGQIITNVYESKEEGWMVGTLNGKTGLIPANYVEPLPGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y649</accession>
    <name>A0A914Y649_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y649"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15670.t1">
        <property type="protein sequence ID" value="PSU_v2.g15670.t1"/>
        <property type="gene ID" value="PSU_v2.g15670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15670.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10051" checksum="6FB21023817E13BD" modified="2023-02-22" version="1">MQVVQEQQQPENPTVVVEEENAGSRVKRWGGYGGNYGGYGGGYPSYGGNYGGYGGGYPSYGGYGGGYGGGYGGGYGGGRNKVVIIKKIIIRDPSMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y766</accession>
    <name>A0A914Y766_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y766"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1605.t1">
        <property type="protein sequence ID" value="PSU_v2.g1605.t1"/>
        <property type="gene ID" value="PSU_v2.g1605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1605.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20273" checksum="E553CBE73FA936EE" modified="2023-02-22" version="1">MSFIFPWEYDFPPFFTIQPNAATREKQLEAWAQLVLHYCHQNNIYTADITQLAETELFNNRNLNRRLDYNGILTVLDYLEAKNCVEWSDRQKRQCHIHWQSPEQWAEVIHSWARANGFLNSVVTLEDLIDGDDTAQESFHGINRRTLIKALEALQKKGLAAIIEHEGAVAGVKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8G4</accession>
    <name>A0A914Y8G4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8G4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15736.t1">
        <property type="protein sequence ID" value="PSU_v2.g15736.t1"/>
        <property type="gene ID" value="PSU_v2.g15736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036757242" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15736.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14042" checksum="613761EA8780CAC4" modified="2023-02-22" version="1">MNKNLLAGILICLIISTYSAPARDNDEEPCDTMKCRDGEKCTHITPACARGAKCELQGICIPAQYAPPDSDEVKNSNFNARFGRNLNADPCENMECEDGEKCLSVLPFCPEDSICHPKGVCVAAPDELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8J0</accession>
    <name>A0A914Y8J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone DnaJ C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13904.t1">
        <property type="protein sequence ID" value="PSU_v2.g13904.t1"/>
        <property type="gene ID" value="PSU_v2.g13904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chaperone DnaJ C-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13904.t1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26727" checksum="E3A0CBF12623973B" modified="2023-02-22" version="1">MSFSYTRISRDNGPGGIFMETFSHRRTSNTNAETFQEENFNRSSRPTATAKRQLQDPIVQYDLKVSLEEIYKGCVKNIRVTRKIFSRDGSSKSEVKMLKVNVKPGCKDGAKFIFPKEGDQIPGHIPADIVFIIKDKSHPEFNREGVNIRYTQKLTLKEALCGTTIYIPTLDGTIEQVEIDRIVKPNTTQRLAGHGLPNPQMGNQRGDLIITFDVEFPNSLSLQRKELLQKSDHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8Q0</accession>
    <name>A0A914Y8Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxin-14</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8Q0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16570.t1">
        <property type="protein sequence ID" value="PSU_v2.g16570.t1"/>
        <property type="gene ID" value="PSU_v2.g16570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16570.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21840" checksum="99FA76DBB0D73560" modified="2023-02-22" version="1">MVVIGGASYMAYKVMRTWVLPKFFNIPEPGNEKLEYLQNQVNDLQNSTKFIMDSVEQTLQTVSAQQEQLNRALLLMSNNNGGNKNNEMNKLQTDVSIIKSLLLNQNQFPAIPSSPNPSSATIPTANSTTTTNGVLKQPKTVRWQTNSIPSWQLAENGNNNHSNGTHSNGKHQNAEEEEDEKQEDEEFLEAQNYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA29</accession>
    <name>A0A914YA29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA29"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16142.t1">
        <property type="protein sequence ID" value="PSU_v2.g16142.t1"/>
        <property type="gene ID" value="PSU_v2.g16142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16142.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16971" checksum="6581B6FC583CDC7C" modified="2023-02-22" version="1">MYSFDYGYGIYQLTIPEPKCDDIWNWKHSVNTGITVIHQKIKIASDWMKRQRGQAFNNTGHAVPVPCLKVKNCVFQESTSEVIDDAVAIKAFNGAPLHYCAWNNAQKCWYFVVVDNNNRNYVESVCSQVPATLKTCPSPDPYANNLCSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAG9</accession>
    <name>A0A914YAG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3686 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAG9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17200.t1">
        <property type="protein sequence ID" value="PSU_v2.g17200.t1"/>
        <property type="gene ID" value="PSU_v2.g17200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020958">
        <property type="entry name" value="DUF3686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12458">
        <property type="entry name" value="DUF3686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3686" evidence="2">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17200.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15937" checksum="453070C6802F5A07" modified="2023-02-22" version="1">MSDTHPSAESTAPEAGGTTVDQAVAQGGAYEVLRRRLAEQGQRLQGLAETLNRQRLAEFGDSRLEVVGRFRIRSENNCVGRDIVQVGPDRLLFGYNVFIGLKTPDPHRGCVRPVPAGAGRRRLRRGRAGAEGQLPRPAWLRARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAT1</accession>
    <name>A0A914YAT1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAT1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15872.t1">
        <property type="protein sequence ID" value="PSU_v2.g15872.t1"/>
        <property type="gene ID" value="PSU_v2.g15872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15872.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18222" checksum="C638390A5DAF7141" modified="2023-02-22" version="1">MNSFIDDPGSHVYGSIMDGVFDGHIILSDGTSLTVEKASRYFSPDERPKNYHSVIYHDEKINHDKYRRVKPHDGCGLTKSLKRKMQDIQDAGEGPYATPNYYSTIDNEPVSHLSPRHQDSIFGKFVSNNTKKEQQKRKKRSVFGGIGTSPINGKNIHKVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB42</accession>
    <name>A0A914YB42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Luciferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17429.t1">
        <property type="protein sequence ID" value="PSU_v2.g17429.t1"/>
        <property type="gene ID" value="PSU_v2.g17429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17429.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17576" checksum="6869830CD4CCB414" modified="2023-02-22" version="1">MLPIARWIGYGGETDFHGYVLETVTWATALLANTRNISVFATVHTVANHPVVIAKQIATMAQMSGNRVGLNIVAGWNKPEYDALGVKLPDDHETRYGYAQEWFDLIKKIWHHDGRFDWDGKYFQAKGVYGNPRPEFDPPIFNAAGSGQGLGALQERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBQ5</accession>
    <name>A0A914YBQ5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynamin</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1672.t1">
        <property type="protein sequence ID" value="PSU_v2.g1672.t1"/>
        <property type="gene ID" value="PSU_v2.g1672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01256">
        <property type="entry name" value="PH_dynamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000045">
        <property type="entry name" value="dynamin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000008">
        <property type="entry name" value="dynamin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="17">
        <location>
            <begin position="29"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="517"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="16">
        <location>
            <begin position="651"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="744"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="853"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1672.t1"/>
        </source>
    </evidence>
    <sequence length="899" mass="100941" checksum="D0348DF84753E825" modified="2023-02-22" version="1">MWANQGMGALIPIINKIQDAFAAVGTSLNFDLPQIAVIGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLINDRSEFAEFLHKRGEKYTDFDQVRKEIEDETDRVTGSNKGISDVPINLRVFSPHVLNLTLIDLPGLTKVPVGDQPADIEHQIKAMIHRFIDRESCLILAVTPANSDLATSDALKLAKEVDPQGLRTIGVLTKLDLMDEGTDARDILENRLFPLRRGYVGVINRSQKDIMGRKDIKAALDAERKFFLTHPSYRHMADRLGTPYLQKALNNQLTQHIQDTLPTLRDSLQKKIFALEKDVQEYKHFHVNDPSRKTKALMQMVQAFTADMERSIEGSSSKLVSTNELSGGARINRLFHERFPFEIVKMTIDEKEMRREIQYAIRNIHGIRVGLFTPDKAFEAIVKKQIERLKEPSTKCVDLVMTELSSVVRQCSETVTRYPRLRDCIEQIVTSSMREQEAYTKQQILQVVDFELAYMNTNHEDFIGFSNAEVKASQGQAKKNLGNQVIRKGWLGVHNISFVRGSKDCWFVLTSDSLSWYKDDTESEKKYMLPLDGIKLKDLEAGFMSRQHKFALFYPDGKNIYKDYKQLELSANNLDDVEAWKASFLRAGVYPEKEQQPVDENGTEEDNSSMDPQLERQVETIRNLVDSYMRIVTKTIRDLVPKCIMALIVNRIAEFLREELIMRIYQAGDTETLMEESQVEAQKREETLRMYQACREALAIINSATSSIQSAATGQMPAPPPGQYNNGAPPAMGGMMGDYRSGNPSPVPPRQAPQPPGPGGRAAPPRPMMGGPPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMMGGPPPGNRPLPGVPPMGGAPMPPPTHRPMLPERPIIPRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCV5</accession>
    <name>A0A914YCV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCV5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17119.t1">
        <property type="protein sequence ID" value="PSU_v2.g17119.t1"/>
        <property type="gene ID" value="PSU_v2.g17119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047234">
        <property type="entry name" value="GRAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552">
        <property type="entry name" value="OLIGOPHRENIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN GRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17119.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39121" checksum="10274D1DDCBC90D8" modified="2023-02-22" version="1">MVLKPLEFSDALSDSPWFRQNLHEHEQALDETAKSIKLIADHCRKLISSMRKVCQSQRGFANSLVDFKVATVGSTQTDDERAIAHSVKDFGNLLLKIEDHRSRILSDAETLYLEPLKELVENINTILHDSKRRYDKESQRFYSNLEKHLHLSTARKTDFREADAQLGQQQQTFCQASLQYVSEIQSIQEHLKFAFVETLSTFLSHWLTFYKVGNDANEKFRPQLNGIQQKVQKAKQSFETTQAEANILKTKMLTTHLKTTPFASGSSSDNSSSSTTTSTGNIKQGYIYMQEKSKIPTKISRDVLSRPWTKYYCVFSKETRIFTMIPVNSSAKTVKKKAFWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD67</accession>
    <name>A0A914YD67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15399.t1">
        <property type="protein sequence ID" value="PSU_v2.g15399.t1"/>
        <property type="gene ID" value="PSU_v2.g15399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15399.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26689" checksum="1EB11C0A2D26C45D" modified="2023-02-22" version="1">MPESSVYDFIGTTKYAPREAHKGLPQSRKSDIEAWIYVILELFVPDILPWRDCSKNKDVLYMKELLFTTCYSRRISQVPTCFSSILPLIESTTVVAAPDYEKYFDLIQKDVESRKIKLKQKFKFDATLLDLEIELWKTGEEQSHELEKTKGSMDELKMDSEKSPSKMSTLKSTTPSRTTSITTEHKEGGEEQAILHSSMKCRVVVPPIGHSNGGASDDDSEQAGKGSVKQSNNNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD90</accession>
    <name>A0A914YD90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17263.t1">
        <property type="protein sequence ID" value="PSU_v2.g17263.t1"/>
        <property type="gene ID" value="PSU_v2.g17263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038030943" evidence="1">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17263.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31355" checksum="49B5E5A45E5CCCDD" modified="2023-02-22" version="1">MITCLFVIFIFFRNEHVNVSFDSVYYGYEMKTNIDKILECDVPSLKDLCEKLLQIGLGQLPLSDLNKADTQRIIDSDIQQLLTISTIFAWWKSNFSTFQFETVDLFKKALVPVTSVIQAMFQVHGFPVHAFNVLAKENSVPIIPPSSENGSTAEVKYERHDFPHLDDVSLKLVSNTRYGRELLVEMKEFEPVNEMVGDIDTILKFIFDKNTLALQDHFCFESKTTEAAKRIKCVEKWNSRNKKHVLPAFFKIRFLSNTKVYEEAKEAMKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YES8</accession>
    <name>A0A914YES8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YES8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18773.t1">
        <property type="protein sequence ID" value="PSU_v2.g18773.t1"/>
        <property type="gene ID" value="PSU_v2.g18773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18773.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7437" checksum="3A44BDCD8936F99E" modified="2023-02-22" version="1">MGERKYFGLLKNVQHVKALEAEDKNIIDLIQSNLFAQLSPITGEDCACPSPNLSTDKCVFAGHCRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF66</accession>
    <name>A0A914YF66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17400.t1">
        <property type="protein sequence ID" value="PSU_v2.g17400.t1"/>
        <property type="gene ID" value="PSU_v2.g17400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17400.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24639" checksum="0E8BEF9FFC635DA9" modified="2023-02-22" version="1">MVDDGQGLKQDLLDNDGCPVDTVLLDSIDYKGDLEAGKDSFVFKFADKPTVFFSCQLRVEPKDADTGLCVRTSDHCSDNTEDFENSEDTTSMVSIEPDFPRPSTPRFKPTTPSSSMTEAFTDMLPSEMPSNSFENLSENNQMTDESMMMPETTTPQMPKRKKIKARRPPRKIIDEGRPFPEFVGVQRDLGIRRKQPSPDAIEMDVNAGAMEVIDPPEICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFY4</accession>
    <name>A0A914YFY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18364.t1">
        <property type="protein sequence ID" value="PSU_v2.g18364.t1"/>
        <property type="gene ID" value="PSU_v2.g18364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18364.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33241" checksum="AD9DC785CA1D9CD0" modified="2023-02-22" version="1">MKCWKCPCKEKVMCLMENKTFNDDSDDDNSDDDDKQTEKKREVTPPPSIMPFDTKKSKKSPEKEHPIQPPPSLIPLEPEFLGPKKLDIKVNETDKVKIVTYPTDEDGKVGEKEYLVYKLLKDAFNYSPELPPAANIFTRKGFESVNFSYDSVKNRYQLTYDPEYVRGIHLSQGFSSALGFKQLIFNDNIATNPPKIENLHSHIHIYVNNVICPIFCGTNQESILDILPITPDANPISKTYERPNYLRIHLNSINTIEMEFKDIHGNPIIGDNATGHFTLEFVKFYKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGB6</accession>
    <name>A0A914YGB6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGB6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18494.t1">
        <property type="protein sequence ID" value="PSU_v2.g18494.t1"/>
        <property type="gene ID" value="PSU_v2.g18494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051503">
        <property type="entry name" value="ComplSys_Reg/VirEntry_Med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785:SF2">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="194"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18494.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40510" checksum="C12763B9CD960ADC" modified="2023-02-22" version="1">MTPLLQAGAVECQNGQWVSKLFPCVSLNRTAVAPKKRRTDSRLCPPPMLDKKFIALNVENWAQNHEAYFPHGTTLEISCTSFSPVEKATFWKCRRGKWQIQGTTPNCPSIDSLCNYKVDRSARVQVFHVETRQFVVFNQQFGIGAKLLFTCANHFMDQLRGSTLMECTGKNEWSSSSPPHCLPLDPEHKQAEPPPVHFTVDSGSYTVSPENELIVNQSATIHLYCFFPKFQGQPKWETTSTYRSLPKSWTKGIHPQFMNFDAYSLTITVAQPEDSGYYYCVLPDHRRTLVQLFIKEESCQHLTETTNLQIIYTTKTLFLGTVAQFSCSPGFQLQGHASIVCLKGGRWSNFPPRCQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH77</accession>
    <name>A0A914YH77_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YH77"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18143.t1">
        <property type="protein sequence ID" value="PSU_v2.g18143.t1"/>
        <property type="gene ID" value="PSU_v2.g18143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18143.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25941" checksum="04A984A036C8E951" modified="2023-02-22" version="1">MIVHEKQLYIIDVSQSVEHDHPNSLVFLRSDIANVSKFFKDHQVPVLSMRRLFEYIVDPTVSDNQAEQMLETERTAEALEEDVLFMNAYIPHKLDNIADYERDDEDEKEGLELNNPFQKIIGKIVDKDNDEDVDDEEDCGNEDETDSSSVTSVEEDLDKLALEAEKERRRQIYHRDRHESPTTKNERKKLVKEEKRVKRTQKIPKHVKKRHENQKRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHQ5</accession>
    <name>A0A914YHQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHQ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19012.t1">
        <property type="protein sequence ID" value="PSU_v2.g19012.t1"/>
        <property type="gene ID" value="PSU_v2.g19012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34851">
        <property type="entry name" value="PROTEIN CBG05235-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19012.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21117" checksum="0958F53B539BBF0E" modified="2023-02-22" version="1">MAEEIFNPSDPKYRCCCGCHVTTGTKIICYMSFFICLLSGIFGGVGNPQYVVPAIVWLAIISFVCLSPIYGIHKQQPGWLIPYLVLSAIGSIFIGLSLISLTVALIPNTTVGERLRLSARERLSYEDKSDGDFTYPLLFLFFQNLISLGLSIWYFMIVYRCYQYLVERKNVYLAQTMYSPTAVLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI43</accession>
    <name>A0A914YI43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI43"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20.t1">
        <property type="protein sequence ID" value="PSU_v2.g20.t1"/>
        <property type="gene ID" value="PSU_v2.g20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15308" checksum="C4A4F2E37D15413E" modified="2023-02-22" version="1">MFSPNEDFTELPSNSLQLLLVPVYLGYIAENITGDSDKRPTYLKAARAYYRSYLERLLAYNVIAFKLPWLDDEGQIIEEKETTELPKIDHSTRRQQKIQRIETQNKLEEALAKLKKERERNDDEATLVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIU5</accession>
    <name>A0A914YIU5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyltransferase</fullName>
            <ecNumber evidence="14">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A914YIU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19433.t1">
        <property type="protein sequence ID" value="PSU_v2.g19433.t1"/>
        <property type="gene ID" value="PSU_v2.g19433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19433.t1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44783" checksum="4AD1E3F6CB192812" modified="2023-02-22" version="1">MATINALDSKQQQSEEECYLSNVVKNDLKTAEAEWNELVTLLSEKLREPTNTKFLPEPSEMLWAPLNIPLERRIQTTAVCYFVFVFILAPVVAVIGPLYLLFFTSYWWLVAIYGGWMVYDRNSHVRGAYPKEWFRGQIVWKYFANYFPIKLHKTTDLLPEQNYIIGSHPHGILGISSFANFATEGTGWSQIFPGVKPSLVTLPTQFQFPIRREMVLMTGTISSSSQSIEHVLTQAEKGRAVCVILGGAEEALDSHPDNFDLKLSSRKGFVKLALKTGSDLVPVYNFGETSTFRQMKNSRGTKLREFQSKFKEIAGFSPPLFMGRGIFNYSFGLLPYRTPINTVVGKPIPVKRNQNPTQEDIDRLHAEYCAQLTILFDENKTKYGINSDAKLNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJC5</accession>
    <name>A0A914YJC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18957.t1">
        <property type="protein sequence ID" value="PSU_v2.g18957.t1"/>
        <property type="gene ID" value="PSU_v2.g18957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037666308" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18957.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17339" checksum="55AE02E05F1EB31A" modified="2023-02-22" version="1">MMIIYSYFLLTIFLMDIPESQGSNFTCFHSEGYFEQYNISQEIIPCPSRTCLMLRTYCDNYWAATCFDPSRPMAIFEDFEMAKKVYETRTHWILSRCPGFKENCNDVYVHYRYSHLRDFPKPITSLDNLIWTNLNLPKPKYLMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJN7</accession>
    <name>A0A914YJN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19530.t1">
        <property type="protein sequence ID" value="PSU_v2.g19530.t1"/>
        <property type="gene ID" value="PSU_v2.g19530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19530.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8907" checksum="D94F7204C5AE8CB0" modified="2023-02-22" version="1">MTLIQNLSCVIIISLTTFVIFTYYIEFEEKQQRTKKSTSSISQINSKSSLKSRKENSQIKVITATPKNAEDGNDADDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK01</accession>
    <name>A0A914YK01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19650.t1">
        <property type="protein sequence ID" value="PSU_v2.g19650.t1"/>
        <property type="gene ID" value="PSU_v2.g19650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19650.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17112" checksum="9867AF65D70723C7" modified="2023-02-22" version="1">MNFTLFETTYFPGAKTNSSEKVCTTGCKDIEWLLTLISTKILQSLTNPSARIRKKRISIITNYYYASGFDEILYSTFYDKFNLTFLYLFVPSKDFLDLPALEASSVPITIFDMSDKNMDFTKANEKYLNQFIGLFYFGKCDLIPWGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKX7</accession>
    <name>A0A914YKX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKX7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20191.t1">
        <property type="protein sequence ID" value="PSU_v2.g20191.t1"/>
        <property type="gene ID" value="PSU_v2.g20191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20191.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="12964" checksum="7522144870550CDA" modified="2023-02-22" version="1">MAMARATVSGPRAAMTASTEGDGSAGNAAFRATGNEPGWLAVVDGDAPGLQVEVDYGERRFDVAKPTEGADGWSGKASDGTDVKLSFQRTTCQDDMSGEAFDAKVNLTIGTRQYHGCGNFGAKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL44</accession>
    <name>A0A914YL44_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL44"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19603.t1">
        <property type="protein sequence ID" value="PSU_v2.g19603.t1"/>
        <property type="gene ID" value="PSU_v2.g19603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19603.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20505" checksum="BC8A3B4CC6FB0B2B" modified="2023-02-22" version="1">MDTKNLKIAELSKSIPDQNAAYTFKNPRPQLFSLSYPIMKYILQNSTGAAWKKLIMTCKYFFSKNPIFPVRQLTTGYEIWNADGKTFNPNQALSHLWLYDVFHGNNAFEHQDNQSMDITLEYVKDLQLSDGYKQMLGNCIAKIIENPPKKIPKIWFPGFINSGQYEEYQKLYRGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL71</accession>
    <name>A0A914YL71_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="7">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YL71"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20100.t1">
        <property type="protein sequence ID" value="PSU_v2.g20100.t1"/>
        <property type="gene ID" value="PSU_v2.g20100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000028">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20100.t1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41058" checksum="41EDCF18E74D168C" modified="2023-02-22" version="1">MTQNSFSRKLSSSRLVKQFAELNFDEDDANDQGFRAKAENRIVFECSWEVANKVGGIYTVLRTKAPVSTDELGDQYCMLGPYNEQQVKLEVEVIEPETAHMKYTLEQMTNWGFKVVYGRWLIDGYPKVVLFDIGSAAWKLDAWKHELFEKSNIGVPYYDKESNDCIIFGFLVAIFLKTFVEAEEGAEPFVAAHFHEWQAGVGLIMSRFWQTRIATVFTTHATLLGRHLCAAGADLYHNLDKFDVDHEAGEKQIYHRYCLERAAAGMSHIFTTVSEITGLESKYLLKREPDLLTPNGLNVVKFAALHEFQNLHAKNKKKFMIFNKGGDMFIESLARLNHLLKSFFKASDSVKAYVFEESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLR8</accession>
    <name>A0A914YLR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLR8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1986.t1">
        <property type="protein sequence ID" value="PSU_v2.g1986.t1"/>
        <property type="gene ID" value="PSU_v2.g1986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1986.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12759" checksum="E5CDCEA5E5D41A3B" modified="2023-02-22" version="1">MASANLKTVAVRFTRSLLLNTGKKINHLDSDSDDSDNNENYHYENLMEVAKKTLTSSNSLTLLKSLTSENDLNGDITKHSTILDEFEEKPIFQIDDDFELPSSSHEHGTVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMA9</accession>
    <name>A0A914YMA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMRFamide-like neuropeptides 14</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20520.t1">
        <property type="protein sequence ID" value="PSU_v2.g20520.t1"/>
        <property type="gene ID" value="PSU_v2.g20520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002544">
        <property type="entry name" value="FMRFamid-related_peptide-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051041">
        <property type="entry name" value="FMRFamide-related_np"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986:SF21">
        <property type="entry name" value="FMRFAMIDE-LIKE NEUROPEPTIDES 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986">
        <property type="entry name" value="FMRFAMIDE-RELATED PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01581">
        <property type="entry name" value="FARP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036836107" evidence="7">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20520.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14297" checksum="94EA5C45DBC14579" modified="2023-02-22" version="1">MSLAHSQMCLSIFLLITIALSSKVVAQSTAAQTCNQILANSSENDERLLLCQLYESSSLLAQLGVLVTEGLDRLMINQGLVTEGENAVAPDAREKRKHEYLRFGKRKHEYLRFGKRKHEYLRFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMG6</accession>
    <name>A0A914YMG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMG6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18515.t1">
        <property type="protein sequence ID" value="PSU_v2.g18515.t1"/>
        <property type="gene ID" value="PSU_v2.g18515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18515.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="12895" checksum="382563275E77873C" modified="2023-02-22" version="1">MACPHTCVRLFALGHHGQGRGIPAGAPVACPVGHHGMGCHYWRRWPVFPDAGGLCGHVPARHEGRTGLFHHQPPGSDYLAVGPEQPTGSGRGAVSHDESRDVQGLPVHGCRYRGPRDRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNL0</accession>
    <name>A0A914YNL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20553.t1">
        <property type="protein sequence ID" value="PSU_v2.g20553.t1"/>
        <property type="gene ID" value="PSU_v2.g20553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20553.t1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36943" checksum="34AB93595E40718F" modified="2023-02-22" version="1">MYRLSHSVDRLPVHLENEQTIYMGENPDEKEMDNAKNKDSKLMAFFKVNEEREKEIDKVKAMIEELKAEGKPINHIKIPDKFLYNKIGITHVWDGKIGKWNLRKKTTKPKLCRLYNVNPKRTNCFYLRRLLMAVSGPTSFENIRTVNGKIYESNREACVALGLVLNDKLYEDTLFEALNHTSSNQFRYLFARLLAHCDLGDPLELFDRFEDHLISDFLKKWQKDDAKKVAWRKIVKSMLNQDKQLSDYPQLEAYMQEIGFENEETIDLKVLLSDALGEYGTMNKEQKAIVDPIVEKLKSLTQKAEKSCTFADGPGNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNT6</accession>
    <name>A0A914YNT6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNT6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20635.t1">
        <property type="protein sequence ID" value="PSU_v2.g20635.t1"/>
        <property type="gene ID" value="PSU_v2.g20635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20635.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13924" checksum="764F2D1F33491262" modified="2023-02-22" version="1">MSNPNVSRFPLILYKRILRLHYGLPTKEMRIMGDSYAKDEFRRHKDATGEHALHFLKEWTDYCMTLSKQLSLKGIAKNREIGRDLDTLAIESLDEQKLLQLYELKVEADKWKKGDKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPF6</accession>
    <name>A0A914YPF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPF6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20874.t1">
        <property type="protein sequence ID" value="PSU_v2.g20874.t1"/>
        <property type="gene ID" value="PSU_v2.g20874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20874.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="23235" checksum="341A65600840C246" modified="2023-02-22" version="1">MIMSKGSLEEINETVCHVSSSPLSPTTNQAILDREASGDLAKEVMLAYAETIIEKKMAARGAPLSPPSTITSPTSAAAIMDVSNNNIPIKKKAAEIIPSDKAVAPEKKLAPKAVEEVSDESQASDIDFEAPKIIEKLPPKMNNNNNLSPALSVTSTNSSSDSSELQAPIKPSTVESIPATAAAKPSTAPSKLAISKTTRSRFNQLQQHRQQHQLLQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPS6</accession>
    <name>A0A914YPS6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gustatory receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2192.t1">
        <property type="protein sequence ID" value="PSU_v2.g2192.t1"/>
        <property type="gene ID" value="PSU_v2.g2192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2192.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33195" checksum="5C762D59DD2ECE8E" modified="2023-02-22" version="1">MFSTQTLEATLHVIESALPLACIIGMMYCSYYMNTLLSALTDIHCRLFPNRHVRRVKFWRYVLYVINGFFVFATLMELPQNFLIELRHPDANNTENLNGFSELHQTPLGHISSTSDKIIVFLDRYYFPLINFGVVKVPQLFIMMIAIRIAVMFRENKKILQKTAVLSRATLEAYFSQLMEIINVLNLLELCFDKLIVAIVTTSVIKIIFTSYGTMREIFNGDPYGSSTGIMSIIKEMENSKSDTNDSFITKDQIVQKLMDQSWGLSLGGFFKIDRAFAMTVNKIKINQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQT9</accession>
    <name>A0A914YQT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQT9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2383.t1">
        <property type="protein sequence ID" value="PSU_v2.g2383.t1"/>
        <property type="gene ID" value="PSU_v2.g2383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2383.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17664" checksum="6F242218EF109443" modified="2023-02-22" version="1">MSLWLYDPFRASHRLQHPFNELAQIERQLDHFFDAPSQQIKLRDHAGQLIHDENGLRYRIDTRGFKPEELKVDIEGDHLVVQAEHKEEHDGESVHRSFVRSVAIPKDIQKEALKCDLDEAGRLVITAPKAGLPDAQKRNIPIEFKKSAIQESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQX1</accession>
    <name>A0A914YQX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21474.t1">
        <property type="protein sequence ID" value="PSU_v2.g21474.t1"/>
        <property type="gene ID" value="PSU_v2.g21474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037379114" evidence="1">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21474.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27191" checksum="A7D38798CC8896D3" modified="2023-02-22" version="1">MKIWILPCLLFCLLIFKPSTASESDQVPKKWDLVRDGCVAEDKNIDACRNTQGAEKKTCSYTKTTGITYSSGTEQTETKEESKEISKLKSHEGTVGVSASFLNGILGANAEATFREEVNRASGKMQSWSSTNTVEASFTQGTEKTEEIIAPEYATAYITARIVTCGPFKIFLGTDVKTEYAKERPDVETEKPKGTSKECDEVFLKEGGKGPHETEKNKYYECMYGKRLLQSCPPGTEFQRSSSGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR12</accession>
    <name>A0A914YR12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Receptor ligand binding region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YR12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2455.t1">
        <property type="protein sequence ID" value="PSU_v2.g2455.t1"/>
        <property type="gene ID" value="PSU_v2.g2455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2455.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10010" checksum="94BFFF6AACEE97FC" modified="2023-02-22" version="1">MFGTSLALTVDAVSVIGKALTSLYSHGNLPVPDTIICESDDTWVDGEFFNEALRQVTLDQSMTGKIIFDGHGSRTNSTITGITRTNEKFQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR96</accession>
    <name>A0A914YR96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19905.t1">
        <property type="protein sequence ID" value="PSU_v2.g19905.t1"/>
        <property type="gene ID" value="PSU_v2.g19905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19905.t1"/>
        </source>
    </evidence>
    <sequence length="773" mass="89099" checksum="28DCDAAA63390563" modified="2023-02-22" version="1">MSEKEDMVVPRSWKYVHRESDVFLDNSDDQNTSKKFYSRIVKQHVYSKWVCYLMRKEVAIERCEYRVNAAICYNGRSSDKLRSIKTDFYINNALYTKMEDNEHMKEYLVLVGDDRIMFWKVENGDCAVISVPFRIEKVFSSEFGIIIERARVVGEEKSGEIPCTIYSLVHPFSEILPVIYKDSYGEDTWYAFSHQRMTLIPSTFDNTGKYFLGYDTEHEKHYVFALRRCTPSEKTDAAKVLTSPFVLPTGSPGSNSTASFSHIRSAVLGSNRSSQSLSARRNAHGTDTPLRRSFRNRAKPKSSKTPVPELNVSYVSSIYSCRSHEQSMLRNIRHTFRVFDLNGVETDELDVDYMFDCVWFEKWGNGIITPQNCCTPTNLTPKSILSRRDNITPTFPAVNFADKVCEENITPSPLFHKRPIQHTPVKPVSFKNDLSSKNSMEIPEEDTCDFKNAKDYSNERLLAVLDQLILRHRNRILQTTIPKEAQKEPRDEQPIAAKDYIKARKNIMKYYTRLMQKGVRSGNKSVKAFYALLLYRKELYQVVKNELKAKASGYVPSRAASRFFVTTDLSGQKYLCFLPSNESTLKMLKWNFEKDALIFLSTVTAFDAVNIPGNNMMAVLNNSAVTLYTGDNVIGTLVTKPFRHSTHELLQFIESYDKTIIVKAQNKKRLFVQNVLFDLDLISSTQIEKLFKAIFSTLPIEKSVKFYSTWYSVNRFGSLDNTVLIKKSFLLELPLMIDHFFTSLGLQVTGLTCMAFVCFFPKHSDMKFTFFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRI0</accession>
    <name>A0A914YRI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRI0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3368.t1">
        <property type="protein sequence ID" value="PSU_v2.g3368.t1"/>
        <property type="gene ID" value="PSU_v2.g3368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3368.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34477" checksum="E77A576A0C10AE49" modified="2023-02-22" version="1">MERKHSLISQCVRTKTINNVMKKSPLSLENIVAKTNVKLGGLNYNIILENYPIDPNVLFIGLGMNHPAGGMADPDGPRVTSVSVLGFSANDGILPNEFIGNFFFQPMSRDENVGVLDTLLVEVLERFKLNRKCAPSRVIFYRSGCSEGAYGSVLRYEIPIIDAVVKKYAPSAPITVIIPSKMHSFRFFKKNINASDRSDDQNIRPGSVIDGVVVNNSYAEFFLNSHLAIQGTAKTPKYTIIYSTEKDASLDMFERWTNALCYDFQIVTSPTSLPAPVYIANRYAERGRQIYNTFPNSAKINKTTGRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRJ2</accession>
    <name>A0A914YRJ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRJ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20000.t1">
        <property type="protein sequence ID" value="PSU_v2.g20000.t1"/>
        <property type="gene ID" value="PSU_v2.g20000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20000.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7769" checksum="3A1CC447A5E277B7" modified="2023-02-22" version="1">MISGNPDLIYLETESFLSQKIIVKIENEEIKSFEIGEILPLQYSDILNNISGYSGLEIEMANSKIRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS71</accession>
    <name>A0A914YS71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS71"/>
    <dbReference type="WBParaSite" id="PSU_v2.g25.t1">
        <property type="protein sequence ID" value="PSU_v2.g25.t1"/>
        <property type="gene ID" value="PSU_v2.g25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g25.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13266" checksum="EC8A11A262593BCA" modified="2023-02-22" version="1">MGCFGSKEFHEKEIGINDNELKKVIFEPQPSDIFDDLDTDNDQKGKVAVDHIFRPTREVYGQPAKDLSDYLIDWGTEYRIALKKRPSPSDFPAFAHEKQQDERKGGDQDGPYKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSJ9</accession>
    <name>A0A914YSJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SLC12A transporter C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSJ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2629.t1">
        <property type="protein sequence ID" value="PSU_v2.g2629.t1"/>
        <property type="gene ID" value="PSU_v2.g2629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="5">
        <location>
            <begin position="57"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="5">
        <location>
            <begin position="261"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2629.t1"/>
        </source>
    </evidence>
    <sequence length="403" mass="45762" checksum="9008AB187BB65229" modified="2023-02-22" version="1">MILHYQAPIGSWGSISQALIYHQVRKYLLLLDVRKEHVKFWRPQILLLVNRPASCCPLMDFVNDLKKSGLYVIGHVNKGNLDSEQSALDPLQQVYPYWLSLVDYLKIKAFVELTLTENIRSGIQQLIRLSGLGAMKPNTVVIGFHELNASETVLQETHLLKDLKFSKIGRSEVVEYFTASDFLPKEMNVDQGRSTPNDYLHILNDIMNLNKNLCIARHFSRFDRELMLKSGGKQYIDVWPSHLFKPEDNGLRWDNSSLFVLQLACILSMSSKWKSASLRVFICVNSLQDMHIQEQQLKLLLQQLRIKAKSVMVPWDHVVAQMKEGTHASANIAEFPKTFVSAVNEMIRRNSSDTAVTFLNLPVPPSPSLNRSDEYMDALRLLTADLPPTLLVCGLSSVISTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTU2</accession>
    <name>A0A914YTU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTU2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20866.t1">
        <property type="protein sequence ID" value="PSU_v2.g20866.t1"/>
        <property type="gene ID" value="PSU_v2.g20866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20866.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23968" checksum="3340DCD3084D6DB4" modified="2023-02-22" version="1">MAIRMLSDNKNGSASNKKQSQNLNQRYQNLNLNQNRASSVTVSPSLSSNNHSNGFGKTKMPKNNENDFDVSQNVSWKNPPKETSRDNFEWKLMHSELNEKNKKAAEKRQNEKDLNSNAINNSTLSLHILAYENGDKRICNNNKTVCANPAEPERDPFNPRKINLKRKSFGGDNDNNDGFNQPETVPFNRKVLNPNEMITDNFDGNDVSKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUY3</accession>
    <name>A0A914YUY3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUY3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3784.t1">
        <property type="protein sequence ID" value="PSU_v2.g3784.t1"/>
        <property type="gene ID" value="PSU_v2.g3784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037663658" evidence="1">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3784.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="36684" checksum="0D819E417D205BB0" modified="2023-02-22" version="1">MHWSCFIPFFILLHTVICDICHDKPVCPSEWIAHKSCGRWFCYREISPLPANKKNIIGVTNLCEQTWPRSHAVSIHCKDENDYIKTNFGNFLIGLTIPANTSTRSFGWSDGSILDYLNWATSEPKNIQTNDIVEFSTAWSATKTATLTKLLCKKKPDRILRTCTPEPDPTCPPVVPPLSFTCDNTNNFAGIQVAGGTFVDNKGYGKADILGMCPTVGGPFIYYDGRTPAVPTKDGKSAAGTVMMSGCTSMCVCDDAGKCYKSDNPSSTEITMYPHCDESTGACAVYAVLKGTGKLVPDSGGATATFTSQNQMAANGFPLPVTNTAYLKVAKLGCFGCPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV23</accession>
    <name>A0A914YV23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV23"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3827.t1">
        <property type="protein sequence ID" value="PSU_v2.g3827.t1"/>
        <property type="gene ID" value="PSU_v2.g3827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF25">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3827.t1"/>
        </source>
    </evidence>
    <sequence length="722" mass="82880" checksum="AF5FB835CE6865D4" modified="2023-02-22" version="1">MKARKARKDLASARVESLQMKNLISENSKLKSKNEKLEERCALLNNRIFELEKTLNIVNEELAALKKDWAEKDEQKKVFLKAGIGFTPEANVAFGELSIMCGIPQDKVGTALLTIAKLFNVEVDSIPSARTVGRSYFAVSSICAKQIAELLEYGENLTVLSDETSKFFQKFQAFVAAGHNKLTGEEFLIYLGVFEVPDKSALRSLEELETVVKGIANTVGIDPDLFWKKFVISVKNLGSDRAATQLCFNRILAELRKLFLEESQEFNDMSEEDKAKFIRINSIFCILHIIQNLTKVVLKILLEHEKKETNNPSLKKSSIEWLIVEIARYFGARSAAKHRSARDWKILAEELQWEFANFSSFHGHRFNIIFVIASQILFNREKLIEFIEKYASDLEDTFKLATALKNPLLIMHLQILATIDSLITGAFWRLAENNDNFLKSKNYVEELLVFLNRVKEEPMLFFACEAPLDHFEDGKPQSKESKAFRQMLEDSEPIPGSSEVVFSLAVAVHSYFIEQFDFQLSDEFKTISEDEFKGAPSTNRVCEAAFGFLDYLFKRAPNMSTSIRSITIVARKNNVFKYLSSLSKDKYDLVVKEASEARSELAKKSQEKAKQLKAELVEQMERHALNRQTVNLRNQERLTRIREEVNKIGFWRNPEEMNESILLLSPRQKFEAVKANIRYRKFIHQVGFEPELLFRFSVNSRQHNLEALQENLCQLMLSSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV77</accession>
    <name>A0A914YV77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV77"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3568.t1">
        <property type="protein sequence ID" value="PSU_v2.g3568.t1"/>
        <property type="gene ID" value="PSU_v2.g3568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037759018" evidence="1">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3568.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="16572" checksum="F7DF658801D7F07A" modified="2023-02-22" version="1">MKPFIIIAFCGILAVYGQASNETVVEVVSNAGNTTDVVSVEIPDASVAVVEPIESKQTVSLQSAEKPIVKAADDDNSNLVANAVDSTNNAIKDASDSIASAAESAKSSANSAADTISRKATEVRQSAEHGVNGVVENSSASTFIASSLVLVFAFINSIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVB3</accession>
    <name>A0A914YVB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4533.t1">
        <property type="protein sequence ID" value="PSU_v2.g4533.t1"/>
        <property type="gene ID" value="PSU_v2.g4533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="12">
        <location>
            <begin position="304"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4533.t1"/>
        </source>
    </evidence>
    <sequence length="422" mass="47542" checksum="8141592E949F9870" modified="2023-02-22" version="1">MLKLLNKLKYRQVVVLSIEGDVNGQEFTTAFEDYRIEYEIHVQKYIELYLNESLTEIIAKEFEEVTSNTIIMCAKKANAETIFLHAQNLTGFGKMWIVNEAASQASNLPKGFLSVHLKQNAVSALRDALIVLKNGVKILENFNGTILPPSQCSNTLISNEWTNTVGTMFYRHLISSTIFGEKNQIKFNSKGDRISIAYEILNRQLEKFLVVGFCNDEGDLFLEESAIIWPGTTKIKPLEITLPKHLRAVTVADPPFVYIFEVDDPNKCSSFKIIPVDDVYVPGPWLPCPIHRSDSDSASKVVYCCAGYAIDLLSNLSISEAGAMIDTGFTFELHLNTSYGIVQLGENGYSLNGIIGELDADLADIAVGALTINSEREQYIDFSEPWLYHGIRVLEKWVRVSLFPRIFILLHASFYLFSFFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVP8</accession>
    <name>A0A914YVP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVP8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4655.t1">
        <property type="protein sequence ID" value="PSU_v2.g4655.t1"/>
        <property type="gene ID" value="PSU_v2.g4655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4655.t1"/>
        </source>
    </evidence>
    <sequence length="747" mass="83679" checksum="25080B52A76C15B4" modified="2023-02-22" version="1">MYFFLNVFFVIKSYNFLDDRSISTSLIESHPRPPSVSEGTTSALYTELQKTAATTTTTTNSSSQQPSPLDGADSGIGSDSPKQTMAPPVPPKPRRPSSSIDLDPDDPMRSAYEDSTIGRDHSVLPASIRPSSRTSNHNQQQSNHRASSPAESTATGRSATPRIEPDLVAKDRYDPSSKCFSYVPAKALKEHYTAPKKPPTSRRQSLERSDLDIPTMDKEALRNISITPTTELIRRAETPKWDSVVDKIAPKIDLPDVRKDFRQLEKERYNGGGDYFSKTLPNGYIGGNGNGYTNNYEDEFEKPVIVDQAKKAPPPRRRGRYGSYSTTNDDYNSDMDDLMDPEFYLSYSAAPTPPPDRFASGSKSVELPRKQMKTISQRDLDEIDSIIESTTTTTLPPARSCYTPKPEPPRPSAERDAFRLRNCRSVNSGPTTRKLFSNERYDSITDADTPDDWLKNKLRTLHSKRGGYPDAMQRKNTEKKLLEELKNANPNNQLQKGEYVSEGIGQQQQQQQQRNGGNMNDSQIDLIEEYQKEEERLRNTRSPFTAIDDFRSMNRAQTGTPNSMIGYNGNNSRYGRGTTPTTQQQIIRSKPPTPPPRERSKSPTIRSPQPFRKSQTPSAYQQERSRIASTEYLSDDDDDTTEFSHLHSLVNDSNNKRAQTAEPSNYYSSSNGTGTKSILKRGNNNNSRQSQNGTPISYADSSLMDDRSEKKDIYASPVPSSRRFGGTSSATRTASFGEVCFILFCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW35</accession>
    <name>A0A914YW35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YW35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4334.t1">
        <property type="protein sequence ID" value="PSU_v2.g4334.t1"/>
        <property type="gene ID" value="PSU_v2.g4334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000658">
        <property type="entry name" value="Protein CBG12184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4334.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36482" checksum="3737D1D7C469EFF9" modified="2023-02-22" version="1">MTFPDPQNLIHPTESIASINVREKLSSNSINLQNKILGAGSYSKVRIGHHQGMGKYVAVKQIDLRQENEYIRRFMPRELKIIEKLKHPNIVEVYQLIRTTNYVCMIQELAAHGDMLKLIKAKKRLDEPESKFLFRQLVEGLKYLETLKIVHRDLKCENLLLDEYDNLKIADFGFARVLKDDEESYTFCGSRAYVAYEIMTSKAYRGNGVDIWGAGVVLYIMLNGVMPFDDKDIKSLIQHQQKQKIPFSRKVSKPAKDLILSMLHPTPTRRATLKSILASEWLDGTRYFMRGLVEEETTCSTASLISDTQLRRMYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWA9</accession>
    <name>A0A914YWA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4399.t1">
        <property type="protein sequence ID" value="PSU_v2.g4399.t1"/>
        <property type="gene ID" value="PSU_v2.g4399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4399.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28810" checksum="2F6F5963344C3A60" modified="2023-02-22" version="1">MQKKKEQKMKEIKEESEEAKKKETTKIKMLLLQKQKKSKRKREKKKETHEVEMIKIGVEVTATIYQRFSKDQKITFNTSTKDFIEHLETPESGSLTGGQLPYTPMTTLRGHRRGLMNRVLACGPSKDLVLHRSLITTKTNLPMTNSFTLDISILLSIPVAPQMSAQDREILQLLQIIARHHHSGYANEFEYIVDEMTRLAEILEVRPDSTLRIMILTAIMSKKNLSQRSQKILFNTLNNEIEIDRVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWZ8</accession>
    <name>A0A914YWZ8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YWZ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4630.t1">
        <property type="protein sequence ID" value="PSU_v2.g4630.t1"/>
        <property type="gene ID" value="PSU_v2.g4630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008726">
        <property type="entry name" value="PRK11728.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF2">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4630.t1"/>
        </source>
    </evidence>
    <sequence length="422" mass="46661" checksum="A46064A933154063" modified="2023-02-22" version="1">MSLAAAAANASRKSFDVIIVGGGIVGCATARNLKIVKPHLNVGLIDKESHVAAHQSGHNSGVLHAGIYYKPGTLKAKLCVQGIDLAYEYLQKKQIPHKKVGKLIVATEENEVPHLLTLYERAQENKCREIQLIDGDKIKEIEPNCRGLRAIWSPYTGIVDWGLVTKYYAKDFTDDGGEILFNHKLQRIELSSGEYPVRIVTSGTNSQLECKYLITCAGLHSDRVAQLSGCSRDPKIIPFRGEYLKLKPHMKNLVRTNIYPVPDPRFPFLGVHFTPNMNGDILLGPNAVLAFAREGYNYSKLSPKDVIDAVFYPGMLKLMMKFAVFGSREMWRSVYHRAQVKLLQRFIIPELKASDVERGIAGVRAQAMDSEGNLVDDFVFDGGIGDLGSRVLHVRNAPSPGATSSLAIAKMVVEKASEKFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXN1</accession>
    <name>A0A914YXN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2849.t1">
        <property type="protein sequence ID" value="PSU_v2.g2849.t1"/>
        <property type="gene ID" value="PSU_v2.g2849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2849.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20125" checksum="7E000E0BD703E0E2" modified="2023-02-22" version="1">MDKYQKKLLPKNEQLHKTALKFARKSSSYEVIKEVANNRNKLQNDRFAEMLIKTMKDCVDSAYIFASFRRQIRENANFEQILENQDIMKQSLNLLVRNMHLNPQRLPPAGIPTLDVAPQNNSFLRDERVITPPPAPAQRNAPRTQLQQLHRPTVPPNRAPINSNGNYLYFFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXN7</accession>
    <name>A0A914YXN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4408.t1">
        <property type="protein sequence ID" value="PSU_v2.g4408.t1"/>
        <property type="gene ID" value="PSU_v2.g4408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037480485" evidence="1">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4408.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22940" checksum="411B81B11E71239E" modified="2023-02-22" version="1">MRYLILFTVFGLSAAKQLTIAVRDNITHACPNVKSDIIDSKSMKLDFQMIGTPDGSQKSDQVTVISQNGESRTMTFPGCYRVTLSFKLKQKLENPYIESFLQMGTNLPCQSGDQEPIGSISNVCTNITQSNWCPLSQHGQLRNMLQAKSTCRFCNLCGSLKAEESTLRKYITPENGADKECKTTADYQTLTFKVQLFKLQSLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXZ7</accession>
    <name>A0A914YXZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4516.t1">
        <property type="protein sequence ID" value="PSU_v2.g4516.t1"/>
        <property type="gene ID" value="PSU_v2.g4516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4516.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22206" checksum="4415F9FF7EE5A295" modified="2023-02-22" version="1">MDSENDSSNNTNVSFQQLFAHSFILWPTSKVFEKTLFGPLAHKGPIPVLRHSYENFKEFLIFMYLGKCNITMENVMALVDLGEFYDVKLLKDQCDEFLTENSTKFENVLKVYESAKVYLLINTMKKVMEFVAQNTVEILKMAEFLNVQRETIVDIAKMKNLNAKHEEVFEASADLMGRTSQVRVQFCTNLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY52</accession>
    <name>A0A914YY52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g503.t1">
        <property type="protein sequence ID" value="PSU_v2.g503.t1"/>
        <property type="gene ID" value="PSU_v2.g503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g503.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14828" checksum="DCBA14EAEFF6E241" modified="2023-02-22" version="1">MTPIQNDALLASTPEEEEAXXXXXXXXXXXXXXXXXXXXXXXIEPDPASGSTIEEDPENPASEDDSDALLASTPEEEEADEEDDDEAMEGSDNEDSHEATDEQRPESLQELNRPSPVPSSSSPFDDDQPPILEPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZJ1</accession>
    <name>A0A914YZJ1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5514.t1">
        <property type="protein sequence ID" value="PSU_v2.g5514.t1"/>
        <property type="gene ID" value="PSU_v2.g5514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036860471" description="histone acetyltransferase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5514.t1"/>
        </source>
    </evidence>
    <sequence length="500" mass="57254" checksum="76B9CD5217B84125" modified="2023-02-22" version="1">MDIAVVIFAAFCFLLSRVEKIPGTPERPLSEAADFLYYRYYYESFLEMVFSWWQCNERDGIDSEKQSFNLGLIEQWTGISKRDMLKVLHSEGIVDVVRFPEDPTRQPKLKFNIDQQELIDHMEKQMAKKNRYWIKKIYLQWKPDFGNIEERIHFPLIQAEYEAREAGLLFENPATIDEEEEGEEEEEEPAKQPVKKGRKKKGEKKVPKSKKKKKTIIHFRHGDTNEEFDAKNPFEDLTRSAVFTNKDFLYQTLPYIRPSKKSKKRPTTTGKRRRKAKKKDSEAAAAATTATKKVEEEESDEENIPNLFTDPDDDDDNEIEKNKVVKKSKNVDETISDKNEEEDEEPESESEVEAEEDDEPQPCSSKTPIKKVLKQPKSTKKPPPPKKKSPPKRRGRKPGAGSSCKEKSPKDKKPPPSSDEDSDDEDGPKPRRPPTRPRGRKRTTTPKANKPTETKPAESADAPGSCNVMSDLPKSSMAPSAPLKEEKEVLKGSSGKLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0C6</accession>
    <name>A0A914Z0C6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZIP11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 39 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Zrt- and Irt-like protein 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0C6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5799.t1">
        <property type="protein sequence ID" value="PSU_v2.g5799.t1"/>
        <property type="gene ID" value="PSU_v2.g5799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF211">
        <property type="entry name" value="ZINC TRANSPORTER ZIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5799.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="33377" checksum="11CABBAF97AFFC7F" modified="2023-02-22" version="1">MILGYPPVLQALFASLFTWFVTALGAALVFVLPSNSKKILDVSLGFAAGVMVAASFWSLLAPAIEIAETKFEQWAFLPVAIGFAIGAGFVELSDHLIPSCVNTELSILNVLTDHTHSDANKRSPGVVQNDAASNQRMISEHSTVDRVANPRDDPDSQSYSVSWRRLMLLITAVTVHNIPEGMAVGVGFGSIGKTPVATFEKAFNLALGIGLQNFPEGLAVSLPLAGFGYPKWKAFFYGQLSGMVEPIAAVLGAALVILMEPVLPYALSFAAGAMMYVVFDSLIHEAGRNGNEKMASASAIFGFVLMMSMDVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0M7</accession>
    <name>A0A914Z0M7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Cell membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0M7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5437.t1">
        <property type="protein sequence ID" value="PSU_v2.g5437.t1"/>
        <property type="gene ID" value="PSU_v2.g5437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090533">
        <property type="term" value="C:cation-transporting ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
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    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.1110.10:FF:000038">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
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    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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        <property type="entry name" value="ATPase_P-type_domA"/>
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    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
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        <property type="entry name" value="P-type_ATPase_IIC"/>
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        <property type="entry name" value="P_typ_ATPase"/>
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    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
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    </dbReference>
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        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cation_ATPase_C"/>
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        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 19" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 19" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 19" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="74"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="822"/>
            <end position="845"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="886"/>
            <end position="905"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="925"/>
            <end position="946"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="958"/>
            <end position="974"/>
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    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
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    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5437.t1"/>
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    </evidence>
    <sequence length="996" mass="110789" checksum="46075E4249AE23FE" modified="2023-02-22" version="1">MVKKNGRSDLNDLKQEVSMDEHQIPLEQLMRRYESDINKGLTTSKAAEIMTRDGPNSLSPPRTTPEWIKFCKNLFGGFAMLLWVGAILCYIAYAVDYFSMEHPSKDNLYLGIVLMSVVIITGCFQYYQENKSSKIMESFKNMVPTIALVYRDGQKVQLPTEKLVVGDVVEVKGGDRIPADIRVISAYGLKVDNSSLTGESEPQSRSPECTNENPLETRNLAFFSTNAVEGTAKGVVVNTGDRTVMGRIAHLASDLDAGMTPIAREIEHFIHLITGVAVFLGVTFFFIAFALGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHTWYDKNVVTCDTTENYGGRGASHDRGQTENALLRIAALCNRAEFKPNQDKTPVLKRECTGDASEVALLKFAELSLGDVIGFRSQNPKIAEIPFNSTNKYQVSIHETSDGKQGYLLVMKGAPERILDRCTTMLLNGTEVKLDDKLRADFNTAYLDLGGMGERVLGFCDYRLDENKYPRGYSFDTEEVNFPVNGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISEESETVEDIAVRRGILVEQVNPREANAAVIHGSDLREMSADQLAEIINHHNEIVFARTSPQQKLMIVEGFQRQGQIVAVTGDGALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLMYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRLPRDPLHDKLVNERLISLAYGQIGMIQASSGFFTYFWIMADNGFLPWDLYQIRAEWDSRAVNCVVDSYGQEWTYANRKILEYTCQTAYFVSIVVVQWADLIISKTRRNSLVQQGMSNWTLNFGLVFETILAAFMCYCPGLDRGLRMYGLRFSWWFCALPFSILIFIYDETRRYCIRRWPGGWVERETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0V6</accession>
    <name>A0A914Z0V6_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="PSU_v2.g5515"/>
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    <proteinExistence type="predicted"/>
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            <begin position="744"/>
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            <begin position="146"/>
            <end position="161"/>
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        </location>
    </feature>
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        <location>
            <begin position="193"/>
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            <begin position="206"/>
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            <begin position="224"/>
            <end position="235"/>
        </location>
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            <begin position="300"/>
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            <begin position="712"/>
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        </source>
    </evidence>
    <sequence length="769" mass="84066" checksum="A8919A976B2A5F0B" modified="2023-02-22" version="1">MQVKIRGSSVEHSSSDSDGPPRPLPLQKPLDYHTFSPPLDDAFQMSPIAATATTSPRRSQKRSSRNRSVSFSRNAKESRTSSDYDDAILTHPQPPPITIAPTTLQRSTVGNDSHINLNFITDNSCYQNQPQQQQHENQRQLRHQHQQNFSYSDSNRNAAAASDKDIPGKEEIEMPKLIPTTALEVPIQRMEINDNNADNNDNNDTINDDDDDDDDDAPPMLSPNFATTNPSNHSPQEGDDDDEEEGGRGGERYTPPNLHNNNSNSNEAPLPMMEEGPPILKNTSSIPGVESVPSHRAPESLQNSGSRRSSTEMQKQSHSVPSQGTLIHQLPPQQPSQPQQHIQQQQQQQMQQQNAWQIQNEMYNSQAAPLSHLSSQQQQHLQLQQLQEQQQQLQLQDQPRSHPQQMTPLQQQQQMTPQQPASMPMPMSDPNSVYSMHSVQSQPPPPTIMPPHLPLPLPQQQQQQQQQQQMHYPLLQQQQQQPQHQQEARKSVEHIHQQLQQQQQQLSHSQQTLQQQMLQPLPQHLHQQPEPPKSKPKPKKKKKEPASSATSSSSAAAAAAAAALQNPMFSQQKYYDAATAANFGFFPPSYMAAAHMAQFQAGPGYSPYSNPYSSTMPNPTNSYQTQHFNPARFNPWTGQPTAAGGYPGYPPFMQPSAAAAAAAAAAAAAHQNPSRLYSQIGGAGAAGGNPFAAIGGGSGGGGAGSAGPSTVTPQNPTAASAAAAATQLPTNAAAAAVAAAQWAQNPTQNPSTTNPYLPPSYPYNMFQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1D9</accession>
    <name>A0A914Z1D9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHK kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1D9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4084.t1">
        <property type="protein sequence ID" value="PSU_v2.g4084.t1"/>
        <property type="gene ID" value="PSU_v2.g4084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012877">
        <property type="entry name" value="Dhs-27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07914">
        <property type="entry name" value="DUF1679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="158"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4084.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="49879" checksum="6BBE4BE6550BE4ED" modified="2023-02-22" version="1">MSDINVAVNGDKFDLSQPIGDYSFTFKWLLDSLNENDEKFQKFHKNREIEKITFSDISDGQGYFSAVLRFIITFTDSSKAPSDDAYTTVLKIPGTVSFKKANSKSGGNNEVFEAVANVASIHQHECIFYNQIAPILEIPLPKVYKTVEIDLQNLEGCIHMEDLSNLGKTLSYFESVNLTQIKCLIQTLAHMHKNLLTTDDAIWKNKFMKHQRGFADITTFFEDLIEPFLQKCKRRNAFEQYLEKYRKFAFNKDYMIYVHQQSHQDLEISPVIVHGDIKSGNILFSIDANGDIQNGIASIIDWQVLREGSPMYDLAYFLVHNTDGVVRRQAEVFAIQYYHECLVKEFDGDKSKVPYTIEQLKHSYNYVFLTQAFFIPFLAVFMFNGMESKIKSQSLKDAFFDFITLKSLHAYEDADRLLKNEMKQVFEKYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z266</accession>
    <name>A0A914Z266_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinase</fullName>
            <ecNumber evidence="8">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.140"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z266"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6456.t1">
        <property type="protein sequence ID" value="PSU_v2.g6456.t1"/>
        <property type="gene ID" value="PSU_v2.g6456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051765">
        <property type="term" value="F:inositol tetrakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF51">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6456.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="35509" checksum="0BAF4792F55108B2" modified="2023-02-22" version="1">MIYSLSMEMYENEELPATLEWYKDQIAGHHPSVVKNGIRQIGIVKERGKEQNLLKLVQDGMRGISEVQFYDSIFQKDQSNHTKAQAVALEGLRNFVPHYFGKRVIEIASRSYEFIELEDITHQYRKPCIMDIKIGKVTYDPDASEDKKHTESIKCPHQKEFGFRILGYRLHPDERGQIRVRDKNWGRTRTPENIQIAFDEYFQAIPSKKLKSDAIKVFRKELAKISEWFDTQQEIQMYSSSLLFVYEGDPHYHTPAKMKMIDFSHVFYEKQYDENYIHGLKFIDNVFQCIEKTDINKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2G2</accession>
    <name>A0A914Z2G2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2G2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6545.t1">
        <property type="protein sequence ID" value="PSU_v2.g6545.t1"/>
        <property type="gene ID" value="PSU_v2.g6545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6545.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15504" checksum="DDA6094D203F32DB" modified="2023-02-22" version="1">MVLSSQRQPSLAGINTSNMTKSFGNFENTVTTRATSLPHHILSTSLHNGTTLIDHHTTLPRKSIHEQEPLLTNNSKSSTPAMMRPPGISPTCPRHGRAAQQQAQMIISAQHQQQQYPSSRANSIGSALTLGTNMGPTLEEVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2I9</accession>
    <name>A0A914Z2I9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2I9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g611.t1">
        <property type="protein sequence ID" value="PSU_v2.g611.t1"/>
        <property type="gene ID" value="PSU_v2.g611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17097">
        <property type="entry name" value="FERM_F1_ERM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g611.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="38297" checksum="4951D22CA335B13A" modified="2023-02-22" version="1">MSFLFSGRNKRLIYVKVTTMDADLEAIPIEANCYGRDLFDMVCRIIGMREVWYFGLQHTNKKGFPCWLQLDKKILSQGVVRQADGSYFFLFLVKFYPEVIEDELVQDITRHLFFLQIKQSILSMDLYCQPEAAVLLASFAVQAMYGDYEENIELELDKLLPQSVIDQYEMTSEMWKDRIRNWWLNNSGLTVEEAEMEYLRVAQDLSMYGIQYYPIYNQKDTDLLLGISAQGLGIYETSSRMSPRPFFPWSEIKNIHFNNKLFTIKVTDKSKIKFRAQETSVNHSILDLCIGTHNLYLRRRQADTLEIQQMKAQAQEQRAKRSVGIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2M4</accession>
    <name>A0A914Z2M4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z2M4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6959.t1">
        <property type="protein sequence ID" value="PSU_v2.g6959.t1"/>
        <property type="gene ID" value="PSU_v2.g6959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6959.t1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33269" checksum="68FC5C6A6943DCBA" modified="2023-02-22" version="1">MLDAFTSHDNVSDFTDVYFVMEFMEGDLSQLRNVSLAQQQISYLMYQMFCGVHHLHKSGIIHRDLKPSNIGVTSRCELKLLDFGLACVKDSPMMTEYVVTRFYRAPEVIIGEKYGPKIDVWSMGCIFAELFLKTFLFPGENHIHQWTKIIQIVGSPDLSFYENLPKTSKSFLLSLPKYSPQSWETILHDLLFPAPSESKPVLTAINARELISKMLVIDPNNRITVEEALEHPYVNLWKETSETEDIASVVTTLNLDDYSIDKIKNLLFNEINECFTPELPESSQTNNQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2X3</accession>
    <name>A0A914Z2X3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2X3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7052.t1">
        <property type="protein sequence ID" value="PSU_v2.g7052.t1"/>
        <property type="gene ID" value="PSU_v2.g7052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45580:SF6">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45580">
        <property type="entry name" value="PROTEIN CBG05369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7052.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29609" checksum="30EDF12C11FB2EE6" modified="2023-02-22" version="1">MGYQFRFIARDSGENAIAPRSYEEMLKETLPIPVLSGTVAKEFLYSAKTIIKLPNGTLGINKTELQIWAKRSIENFHYLNPKPTTIVTAAEEYNSIPKSAYIFDDVEQYVPTHNFAVNQVRRGSDVYLYEYIYQDVGDAFDTGPQKIPRYKSPKHAQELSYLLGLHVGNYTAKDHQIRYLYSQIFVDFINHGTPNNSKRKWTKFNPSKNNYFVIDFPDPDLKSPGDKNGYHSEAVNFWNTVLPRVRSRLRSRFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z329</accession>
    <name>A0A914Z329_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Myosin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z329"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6458.t1">
        <property type="protein sequence ID" value="PSU_v2.g6458.t1"/>
        <property type="gene ID" value="PSU_v2.g6458"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g6459.t1">
        <property type="protein sequence ID" value="PSU_v2.g6459.t1"/>
        <property type="gene ID" value="PSU_v2.g6459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF5">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6458.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6459.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18548" checksum="62961CB09A7194D0" modified="2023-02-22" version="1">MISAVLLLGNIEFIKRPGYHSDENAYIGNEELIDVIAELLNIRAQQLHQALTMRRTVLRNDTVITRYNVSEAVFNKNAMAKCLYNALFHWIVLRMNQALIKRDTAIRKKGYYIGILDIFGFEDVGAEWNSFEQLCINYANEHLQAYFNQHIFQFEQVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3D4</accession>
    <name>A0A914Z3D4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3D4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4763.t1">
        <property type="protein sequence ID" value="PSU_v2.g4763.t1"/>
        <property type="gene ID" value="PSU_v2.g4763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4763.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18702" checksum="8EA6588E4386E63E" modified="2023-02-22" version="1">MEAMDEKPAALPFTEPEDILRVLGFIIADADGQPQQQQQQPIAPPQQQPIILVPAFLGFGNNENGFQDIVNNEDDVANDEDDMANNENDLANDENDLANDENDMGRNDIRDMVNNYVQRNDSDDAEGRSEGDNDVEQDEQDLDYDLGEMNDFDDVMVTNIHISYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z519</accession>
    <name>A0A914Z519_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z519"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5351.t1">
        <property type="protein sequence ID" value="PSU_v2.g5351.t1"/>
        <property type="gene ID" value="PSU_v2.g5351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="entry name" value="secretion proteins EscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="EscU C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5351.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11215" checksum="7188988FCD8C776C" modified="2023-02-22" version="1">MSAPKVVAKGAGLVALRIREIGAENNVPTLEARRWRERCIDMRRLVNKSRVNYPCRTDFDPVDLVDDGAATARIHTRPVVYLQYCLVDHGVAGGDVYPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5A2</accession>
    <name>A0A914Z5A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5A2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g543.t1">
        <property type="protein sequence ID" value="PSU_v2.g543.t1"/>
        <property type="gene ID" value="PSU_v2.g543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g543.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7965" checksum="511FB4509C72989F" modified="2023-02-22" version="1">MAESDCHKALRGNCRVRILVLDHTKFGRRAPVRSGSLDDVDILVSDQPIPEPYREQIPARVQIVIADEVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5W5</accession>
    <name>A0A914Z5W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PD-(D/E)XK endonuclease-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5W5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g564.t1">
        <property type="protein sequence ID" value="PSU_v2.g564.t1"/>
        <property type="gene ID" value="PSU_v2.g564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22352">
        <property type="entry name" value="RecB_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g564.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13701" checksum="E85A359E3E811C98" modified="2023-02-22" version="1">MIDLTYVRDGRWYVLDYKSNRLPGYSPDLLAIAMRHSEYDLQALIYTVALHRWLRFRLGAAYDYERDMGGIRYLFCRGLDAAGNGVHVDRFPLALVDALDALFAGGEQAQAELAARARGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z663</accession>
    <name>A0A914Z663_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z663"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8171.t1">
        <property type="protein sequence ID" value="PSU_v2.g8171.t1"/>
        <property type="gene ID" value="PSU_v2.g8171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842:SF1">
        <property type="entry name" value="PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842">
        <property type="entry name" value="PROTEIN TOLB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8171.t1"/>
        </source>
    </evidence>
    <sequence length="696" mass="77796" checksum="59CEC4747474610E" modified="2023-02-22" version="1">MKLLKNKMQYSCFAKKKRAPDGKRVAFGTLGNLKQVYTVSTEIPFSRPHRISTGLGNAMPLDYRPDGDFVYATDAFQYKNLTEAFNATMEGKLLSKNYEIVVTNFLGNFKHRYSTLLPTVIIAVSKNAKYLAVMDNGFQVVDILSGTRTTILTTQGVTSAVFSPNHDRLFFIQTIPGGGSELITAFTNGTGIRSLFKASNEFYALSDVTKDGGNILLTHCKVGMNKINNDDESDSCFLATYNYLTEKMQWIFLSGNRVQGTHASFNNDESKITFVRLDEDDKNDVFISDWMGNSANIINNNNNLKPQRKGKKIISKNIIEGGLKKKAAKSSRYAGFISSNQSSTIVFEGEKHLQNIRQLTFTGQNAEGYFAFQSNSIVYQAAGGDYGSQCDGIYRLNYNPDSEDITPQRLSTGLGSCTCSYLMPDDKRAIFASTFLEANPAKISDPKLGTCNEKKCQSQQAQTDPILKQLCNTSYTWDLHPSYDIFLVDEYGNFLERITDSPGYDAEGAISPDGKLMVFTSIRSGDPEIWIYNFETKKFKQITHDLGYDGGPFFSPDGKKIGFRASRPQTPAEISKYKQLLSYNLVEPNLMELYTINVDGSGIRRINKLGNSNWSPFYLNDNRRIVFSSNMGQQTFGIFNLYVINDDGTGLEQVTNSNGFEAFPMMSRDGRFLIWGSSRGAKASTDLNLFIAQWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6H2</accession>
    <name>A0A914Z6H2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TNFR-Cys domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6H2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7529.t1">
        <property type="protein sequence ID" value="PSU_v2.g7529.t1"/>
        <property type="gene ID" value="PSU_v2.g7529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7529.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36537" checksum="19322FCDC8AA411A" modified="2023-02-22" version="1">MKCPKGKFALNECKKFDNTECASCSDKGYSNTRAYRANCRGFPVKSGAYTIRNGMRKLEPTDIEVPWNNIGESTIRDRREDIDFDNEIPDLPGPFDDDVVDDDEKDDSLDDDDIEEFYNGLDLSEEFGDEPETLDAQIILPNARPIIDQTGVLEVMAMSDDSSSDSDEDLESDSKSLESVEKLRIIVGPLKEEKLKHVNKIVKDSDEEELDRIDETDDVTTQTPKSFNLSESFKELKKNVLVWNLLTKFFVFIAYCFAVMALFIAFRYAQNMRRQRTFNVQPLVMTSDQHYDLVRSVNYLQNKRRGPFKYEPLEEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6W5</accession>
    <name>A0A914Z6W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6W5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5991.t1">
        <property type="protein sequence ID" value="PSU_v2.g5991.t1"/>
        <property type="gene ID" value="PSU_v2.g5991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5991.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22562" checksum="12B11999AE4C80FA" modified="2023-02-22" version="1">MLRLLLRGTIDNFKLRYLITDALGLSIPDLLNQLSINNFSLSSALRLAYETFESLEELHKINFIHRDIKPAAFAFGLKSLNTKLFLTHFGLAKKFRGSADAKLLAPRKTVPFMGTVKYASRTVHERGERSRKDDIESWVYMISELVDEKSLSWRKIVNRDEQNDPWEWEGLEEANEEAKKRKNNTCDSTQQVPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z762</accession>
    <name>A0A914Z762_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z762"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8534.t1">
        <property type="protein sequence ID" value="PSU_v2.g8534.t1"/>
        <property type="gene ID" value="PSU_v2.g8534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052969">
        <property type="entry name" value="Thr-specific_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763:SF4">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8534.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25659" checksum="57EA21C3C958B904" modified="2023-02-22" version="1">MSTAEDFQRKKELARNIDLCFLLDVTGSMQPYIDQCRDSIKQIVEILMPTKTRYSGIAKLLRLSIVGYRDHGDEKQFEILEFTESPEIFRNFVSSVPADGGADLPEDVFGGLEKALDLSWSDQCGTKVIFHIADAPCHGNKYHNLRSGGDDYPNGDPKERTETMLFGRMKEKDIDYHFGRINQTTDKMIQVFSEAYGSEIKQYDILKITMAESVISAVCHSVTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7L3</accession>
    <name>A0A914Z7L3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7L3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8314.t1">
        <property type="protein sequence ID" value="PSU_v2.g8314.t1"/>
        <property type="gene ID" value="PSU_v2.g8314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037503103" evidence="2">
        <location>
            <begin position="21"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8314.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="39465" checksum="CACD98BCC446820D" modified="2023-02-22" version="1">MRLFFVLYFLCLIFITVLDAKTTTSEPIILTVKGSKTTKAPETDIKDSVEEVSAVKNTPKVANKETEEEVVVPINDFKSAISYITTAATVAGKTTSSITTTITTTTTTIKPATKTTPKTVDEEDIVLPINDDKKNAKTTKTTEAVEIGIVKGGKVTTTTIKPAAAAAKATTKVVEEEETEEVIKSGKATTPGKAPPNPPVDPVVTTTMKSGKGGAATTTVSTIPVTTIKPAAAAAKTTIKQVITTTTIKPGKAPTTTIKAAAKTTTTTKKTTTTSTTTTTTTTPAPEGNKFLTFVRDAANIRPTFSICGYFCNILGVKTRKKRLMDYSALLAGLNQREANFKTINKSDFKLAIERNHGLPSPALAAIQSQDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z841</accession>
    <name>A0A914Z841_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z841"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8034.t1">
        <property type="protein sequence ID" value="PSU_v2.g8034.t1"/>
        <property type="gene ID" value="PSU_v2.g8034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8034.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13127" checksum="ABDACF2646C04A80" modified="2023-02-22" version="1">MTRLDTVLSCMVDDSGDHIKQDVVSLTSLSNVLQNNLAMLATIARASRSYSIGLKNCDIELAWALQFSHTAARQSEDELEFILEHFGFIRTNPTIANVGAAVVEFGGYPIERPIERNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8R5</accession>
    <name>A0A914Z8R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8R5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8723.t1">
        <property type="protein sequence ID" value="PSU_v2.g8723.t1"/>
        <property type="gene ID" value="PSU_v2.g8723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8723.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30364" checksum="A1A9F80BF6C72270" modified="2023-02-22" version="1">MAERDNSSSSNNSNSLKKNESRLARSPLNSEKKKQTKKSDDSTNKGPIPQPMKYKPKSPPPANEKVSTPEEEESDSENLKSCERSPTPKVTVISFGSNKNKSSRKSSKKSCAPQLDPDAFFLTVETIMTAAKPLILSVTKSKTIGSVKTAIRAKTKAKNFGIYLNNKELAPEDSTLESHGIISDTKVRLHIKTQSGTSDKEDINSLIRLTKSMNDLRNIIQALPSTSKESKNKEKNIPRNKQVINPEKKAEEDQKSRDKMAKLREKFCTKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9Q4</accession>
    <name>A0A914Z9Q4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9Q4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8536.t1">
        <property type="protein sequence ID" value="PSU_v2.g8536.t1"/>
        <property type="gene ID" value="PSU_v2.g8536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8536.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="20118" checksum="A23FE641110CE55E" modified="2023-02-22" version="1">MALLHVFVAILIWILFYNFYWKRRKFPPGPTPLPILGNIQPMKRIRNGHEVFIQWQKKYGPIFTFWISEIPVITICDYQLMQETFVKDADSYTGKFTVPKMDNFFRGGTFGVVFTEGELWRDQRRFALSVLRNFGMGRNLMEQKILDEIIAFTETLSEDVNESSYLKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA07</accession>
    <name>A0A914ZA07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZA07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g862.t1">
        <property type="protein sequence ID" value="PSU_v2.g862.t1"/>
        <property type="gene ID" value="PSU_v2.g862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006589">
        <property type="entry name" value="PRK09121.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g862.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23317" checksum="B7313AED033760B9" modified="2023-02-22" version="1">MTMIDTLYDAHYKSREKLAWEFAKILNQEAKELEAAGVDIIQFDEPAFNVFFDEVNDWGVATLERAIEGLQCETAVHICYGYGIKANTDWKKTLGSEWRQYEEAFPKLQKSSIDLISLECHNSHVPMDLIELIRGKKVMVGAIDVASNTIETPEEVADTLRKALQFVDADKLYPCTNCGMAPLSRQVARGKLNALSAGAEIIRKELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBQ0</accession>
    <name>A0A914ZBQ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBQ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7678.t1">
        <property type="protein sequence ID" value="PSU_v2.g7678.t1"/>
        <property type="gene ID" value="PSU_v2.g7678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7678.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21368" checksum="4E333A8145923D4A" modified="2023-02-22" version="1">MRSLHTLIRDESPVLELKVDEQVDSPLVLYNRYESGLICGWDVESGEILHSFTDLQSNGITRAEMALTSTALVAFSEDGQLFIWNKFTGDFIIRLVAEETFINETAFFEISQGRILSLGDNNTVVTSIGTCVQFWDVELKALIRQVELPTSIETLLIIEGKAILCVSTNTIYRIDLPLGNLLLLRNRITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDZ5</accession>
    <name>A0A914ZDZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8497.t1">
        <property type="protein sequence ID" value="PSU_v2.g8497.t1"/>
        <property type="gene ID" value="PSU_v2.g8497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052749">
        <property type="entry name" value="Alpha-tectorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160">
        <property type="entry name" value="ALPHA-TECTORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160:SF9">
        <property type="entry name" value="PROTEIN PRY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037571688" evidence="9">
        <location>
            <begin position="21"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="450"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="490"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="11">
        <location>
            <begin position="529"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8497.t1"/>
        </source>
    </evidence>
    <sequence length="794" mass="88132" checksum="26FFD76CF232C808" modified="2023-02-22" version="1">MKVTTLLAVVFFALCATSLAGNNHDYCTSSECQTNRRLSVFERETLKQEVAKYKKILQESSCSVCNIDGDTPCKNNGTCIVTDTYTYICNCPYDTVGDHCENVLSCDDNPCGSGAICTVFNHKKVCTCPPGTDGDPMKSCEFRTKKACMSGDPHYTTFDQTYFHYMGTCPMYVMKACDDSVDWSIIGTNAFFSYNKQVDEALNLYFDDIRVYYPYYWPSQNNPKIVATKPSNQVIIEDTENGAIINFYQYTLCVQVRTTPFFYGNNTMCGVFGSIDDETDSAIAQCGLIKQAIDGQGPFAACQAMNNTEQLYDECVFDICQGFSQCDALDSFAKACISAVPWANIDNWRTGDFCPPTCPPNSHYSMKTPKCQNSCSDPNYSNSSLCQDGYEEGCICNPGYYYDSNGQLDGLPFECRLLENCGCLDTSGNYYPPTSHWLNPNCTAETTCFNGQLVTNTTACSIDGQCNNVNGIYTCQCLPGFTGNGTTCTDIDECLDPTVCSANLNQGICTNFPGTYNCTCYSPYSGAQCTDYTPSRHCADLQIYHGITTDGAYSVSIGPDYSANYTDADLNWTMVYCDMTSQSGGWTLLSHGNNTAGKNFSEYITGFGDAASQNVWLGLENIHLMTQTATSLRLIVTSCPQENIPTDDCTYPYFVVTDATAQYAVFINSTCQGSIYGFRDGWVSWNKNQLGPVFTAWDNDDRSYCSKNFHNTGWWFNHLNNYFSCGYANLNGLRFACGDQDDQYNGQYVMWSNSPAEDAFMYLRPSEYPTYDPLHPAPFPTTEPVEDVTTSYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEI6</accession>
    <name>A0A914ZEI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZEI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8692.t1">
        <property type="protein sequence ID" value="PSU_v2.g8692.t1"/>
        <property type="gene ID" value="PSU_v2.g8692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8692.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="36778" checksum="EE1A00E39C2BA282" modified="2023-02-22" version="1">MDEQSEYLKQTQSQLKTLNESVSKLSGELDLMGAIQVLDGQLSEWTAEARLDIELLIAHGKITTYDPAALPSHETLGHEVVLQKCLPSSGIVLFEQIKTFTKKEHIMPMVNILHVGKYSGDRTSFARINFNRSCAVINGLLVPMLKSHCTPPKTDNFFNKVHICPKVALIHDGCSPDSILSCTVTTEQVTRDHLAIETIKDEYVIATLLKTYTVVNSITGTTQTNQVPENGTFVLKLVSNYYASFNGHQIFGLATGNVSNYVPISSNIIVEAAAEMISAKSSRPFSIVDINRDHVYSTVIGICCSGKGGEHRLEPGVRYISGREDEAKKIFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFD6</accession>
    <name>A0A914ZFD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZFD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8993.t1">
        <property type="protein sequence ID" value="PSU_v2.g8993.t1"/>
        <property type="gene ID" value="PSU_v2.g8993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8993.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17304" checksum="2C8743F0ABDAEAFB" modified="2023-02-22" version="1">MFSDSPNQISNKHKVEWYESPSNNDLTNSGHRQYTQRIPLRTQHEANLRKEAALKSREIKTGDFDLSADDDDDFNNDSLFAKSLMKPLSVDKTSPDLVWKKEKTEDNTLASKMLAHLPGKNITQEFLNLSKIVSSEPSTSLANSDIISSSSSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQA9</accession>
    <name>A0A914XQA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XQA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10204.t1">
        <property type="protein sequence ID" value="PSU_v2.g10204.t1"/>
        <property type="gene ID" value="PSU_v2.g10204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037195491" evidence="1">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10204.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33799" checksum="A4488763089B9D63" modified="2023-02-22" version="1">MKILLCFFLIICHFSTAFSGDVKPPSILDIETEFGYFNASFWWSIKRLHLHNFGSNDEIKSLKSPIFKAFDYSDSDKEYQAQFKISTVYNENILTSYSVEALFSAVPTAFTFCYKIDEEWKCPVENPFTLESTVIKNKMEFEIKFYLKAEFNNNKKTNTVKKDYPPTLPYHGKVESLRNELLKMFDEDEASKFVIESGGEEITAYKSIMQARSSLFKELLSNGTDRLRITDFQPKVIQKMIEFCNSDLIKNFENEETSLFAIGYDYKIKSLMANIYFAKHIFIFFYCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS88</accession>
    <name>A0A914XS88_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XS88"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10141.t1">
        <property type="protein sequence ID" value="PSU_v2.g10141.t1"/>
        <property type="gene ID" value="PSU_v2.g10141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF495">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10141.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36362" checksum="FF39216A64D80AAB" modified="2023-02-22" version="1">MDELWQIAFVRLTKPDEKDRDLVKSSRSMLSSISSTSTKLTHASKKDTEHFEFYFLDKETVVAKKHASRPKFSEHDHVVFRAMQQLSHDNLCRFIGLSMDGPMYFSLWKYCSRGCLRDVIERNQVTMDGFFMISLIRDIAEGISFLHNSSLFHYHGEISSRTCLIDERWQVKITLYGLYPFHYYERKDPENLLWCAPEIIRSDGEIYGSAAADIYSFAITASEIVTQKPVWNLGESELDPEEITYRVKKGGKSPLRPSLTIDTAFDVNTSLLHLIRDCWAEEPSDRPTIKVVQTLLKSMHSGKARNLMDHVFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSJ7</accession>
    <name>A0A914XSJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSJ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10952.t1">
        <property type="protein sequence ID" value="PSU_v2.g10952.t1"/>
        <property type="gene ID" value="PSU_v2.g10952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10952.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30082" checksum="F769FA65EA83F63F" modified="2023-02-22" version="1">MRENTPVSSQEAAAQKNDSEDSVETDNDKPIPAKANVASVVNDQDTNESSDTDDEAPGQKPSENAHKHREHSNHLENVVEDEDSKTKIINDKTNSDKIVKSVDDNVINEKSQKVDDDKTKAAAAALEADKPAATSESEEEEAVESDNRKPLADNTYPKAPAATVAEDRQQQSRESSSSLTDKNAKVIVGDKDSEVDDDSNQKNEEVPAPEKPSGTLTQEENEGVANLTEDKQMDIRKDGEDGLAAVATTTTMKSPNAAPSISVSFSLIFLSIIFFLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT97</accession>
    <name>A0A914XT97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XT97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10190.t1">
        <property type="protein sequence ID" value="PSU_v2.g10190.t1"/>
        <property type="gene ID" value="PSU_v2.g10190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037525463" evidence="2">
        <location>
            <begin position="19"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10190.t1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56394" checksum="39EDDFE250D4D3C8" modified="2023-02-22" version="1">MFFTFLLLLLLLSNLDNAFSLSSKTLVFNNTIDNVPAYYQNFSEIKDKHLNLIPLKRGTLLKLIRPSNAPIKFQLKQSRTCFSKIGFYFYQKGKSKFCQVLVDVAENFIKLEGVSSQIMINGTTKIEIIIKKNSFELKANNTGNVISRTKQCELNIDNPYNQQSVIADFFLFDSNDCEHKLVLPETSQLATWFINTTKSVTTTTTTTTPRTTVTTTKTTTEKEVENAEFGIHWYIVILIAEIVVCIFIGAFSTWLYDKLTKRFKAQQSLSIEDSHDEEIETALEDLQAQSGEVVNQDDKTGLKSLSKNSTGPIVVSSHGSLLQTARQPSNNNQRIIKGKNVESVGISNITLPTHVPHTPMQPQKSKKSFLERMGNKFKRKNKESNSKKFYFQQPQISVSGFSSSTTMNIPFGESKEKKSIKKIKAQAPLSKEYNIDQQGCEPTQASREESYQAEVAEISQGKKNAEMYARIFAPGGRIRTAKELAEYDAQKAAAAASASKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTI6</accession>
    <name>A0A914XTI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TOG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11270.t1">
        <property type="protein sequence ID" value="PSU_v2.g11270.t1"/>
        <property type="gene ID" value="PSU_v2.g11270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="4">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11270.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25024" checksum="87ADDA88A634012C" modified="2023-02-22" version="1">MDDGWDFADPVDILPKLPENFQELVASKKWQERKEALEGLLTLVTENIRLDPKAHYSDIVETLSKILAKDANINVCAIAAKCITQLAKGLRTKFSPHVLTITPIVFEKFKEKKALLRDPLIETIDAVYASSNIEVISDEVAAALGKPNPNIKIQTNQFLYRVFKTFNAQTAPKKVVKALTPLIAKCTGESDAEAREASFAALGAIMKAIGKANAMTICRRSQRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU58</accession>
    <name>A0A914XU58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11491.t1">
        <property type="protein sequence ID" value="PSU_v2.g11491.t1"/>
        <property type="gene ID" value="PSU_v2.g11491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11491.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9969" checksum="89CEA8C470240EEB" modified="2023-02-22" version="1">MLKKLPHQNYSDSQASLLIYAATTAGATVKVLSEEHNTEEIAKALIRQNFGFGGAEMSFAAHYPHDVQHYATYFCKDNDRFIMIGFLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUY8</accession>
    <name>A0A914XUY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10783.t1">
        <property type="protein sequence ID" value="PSU_v2.g10783.t1"/>
        <property type="gene ID" value="PSU_v2.g10783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10783.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20085" checksum="9F6F3F3960DC64DB" modified="2023-02-22" version="1">MSMRGSCMETPLKIQRQVMEVNFFGHVLITKLLLDSIPDSGAIVVIGSLQGKVAIPYRSAYSASKHAIQAFFDSLRTEDRPNLQILTISAGYINTGFGSRALNTDGRPMGVEDENQTNGLSVEYAASTIVKALINRETELLMAPFKLRIAVGLRYFAPNFLFWMLHKRGQKDPHQSKKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVE0</accession>
    <name>A0A914XVE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVE0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11906.t1">
        <property type="protein sequence ID" value="PSU_v2.g11906.t1"/>
        <property type="gene ID" value="PSU_v2.g11906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF452">
        <property type="entry name" value="LD03691P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11906.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29081" checksum="E1862B1BF1E45647" modified="2023-02-22" version="1">MGSFSRWSAYGSIGRLTKYLFIITSITSMILLLVVFVYGCWLNHNRAQYAELLAPSLYVDVSRIMIIVSLIAIINSLIAIYSVSKELRCMIYSYATASFILFIMLLMGGIMGFVFYQKLQNQIPLNLKMLTSLKELYGSADNKPITEAWDDLQKNFHCCGVSDNDNYNVWKTSKWYMHQKSVPKPMLPLSCCIPSLEAACIEGKDINAFYTETCYMPLKTDLLNVVNIAAWILIIASFFMLIPAIFAGVYARLIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWZ4</accession>
    <name>A0A914XWZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWZ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11490.t1">
        <property type="protein sequence ID" value="PSU_v2.g11490.t1"/>
        <property type="gene ID" value="PSU_v2.g11490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="131"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11490.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43848" checksum="44E6B0D0603F5F72" modified="2023-02-22" version="1">MANKESVTENLLQTLSNINYVPLTRQVTSKPYYRRRQVSPKINNDNNNNSITSSFLDEISSINANFSANYSSLLNSFQSFQATSNETSSTLGSSSSSNSPLISVSAAPISIDNLTNILIDIVKPVIPPPRKAFDCLICYTKFYEDEGALACSAPPELETSNENAVKHLICVTCIRGYAHNSIFDGQVAHGGSGLKCVTGECENVLLLSDFEHYLADEDYIPLKTRLQEQCLLDAGLADLVTCPECSYKIIVEESLIFYTCNCGRIQCRNCPRIYDEQHQNKTCEQMAQLELQQASMRRIEPQMSEIMIRKCHRCNLNFVKSHGCNKMTCRCKATQCYLCRQPDIDYNHFCNCGSSARTHGACRVCGKSCRNNENVADLDRQAINRLRNRGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX95</accession>
    <name>A0A914XX95_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX95"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10369.t1">
        <property type="protein sequence ID" value="PSU_v2.g10369.t1"/>
        <property type="gene ID" value="PSU_v2.g10369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038091844" evidence="1">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10369.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9139" checksum="AF73C2E32F4E5137" modified="2023-02-22" version="1">MKAFFFFLTIFCFLTNICLSLECFYSGQIDQFFEECSDTDRFCIQISVNGSDINQKVPSSYQGCSDEMKDLQSVGIKCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXD7</accession>
    <name>A0A914XXD7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Solute-binding protein family 3/N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11874.t1">
        <property type="protein sequence ID" value="PSU_v2.g11874.t1"/>
        <property type="gene ID" value="PSU_v2.g11874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11874.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14605" checksum="E40D2A5C45CCBCF4" modified="2023-02-22" version="1">MNPWALLGTICQYKTGATFKWTTLQLDAFIYDAVVLDYQAGKDADCELMTIGKWSSMTGYGIGFPKNSPHVQKVNQLMLQYHQKGDLERLQNFWLTGACIHSSNSQTTSEPLGIENFMSAFFLLGVGIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY36</accession>
    <name>A0A914XY36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12114.t1">
        <property type="protein sequence ID" value="PSU_v2.g12114.t1"/>
        <property type="gene ID" value="PSU_v2.g12114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12114.t1"/>
        </source>
    </evidence>
    <sequence length="86" mass="9612" checksum="95D2A39E2C4BD381" modified="2023-02-22" version="1">MTTSYNDVQKFLAENKYPNQDTDVAVTQPPQPIAPVQPLISPEQISAQDIPAQCVAQIPVKSSHLRRYCTIFWNEKLCCANCPGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYY4</accession>
    <name>A0A914XYY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4140 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12426.t1">
        <property type="protein sequence ID" value="PSU_v2.g12426.t1"/>
        <property type="gene ID" value="PSU_v2.g12426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="1">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12426.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21609" checksum="9053C3080D2B8609" modified="2023-02-22" version="1">MSSQPSITSFFAPEIPIKSVTVFTKGAEIHRTLKVSLKVGFNEIQILNVVETIKPNSIRVEGHGPATIHGVKLSNEYVYDETCNPQKLKDLKLLIKDLENQIENEKYYAKIYDTQIDVLNNAVKAIGNNQSKEGINPETMEKLFEYHENKYVETKIKAKKIQEKINSFDAEKCKIKVELNKYDSKCIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ08</accession>
    <name>A0A914XZ08_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ08"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13173.t1">
        <property type="protein sequence ID" value="PSU_v2.g13173.t1"/>
        <property type="gene ID" value="PSU_v2.g13173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13173.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18290" checksum="A3CF4E7186AC9849" modified="2023-02-22" version="1">MKAVIIDRNDIIECLLEKGAKCDPPMEVKNSLEVRTTPLMEAILQRNVDAIRLLLQHDANPLLKNRNGETALDLLNEQLKTGHMFLTASNTLLGPKRAKKEMPMSQETFDELKEVEKLLKKAEKEYAENHPEILLRNESVGLIISRKRRHESINPVENIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZM9</accession>
    <name>A0A914XZM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11985.t1">
        <property type="protein sequence ID" value="PSU_v2.g11985.t1"/>
        <property type="gene ID" value="PSU_v2.g11985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11985.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19112" checksum="7B76D975D2AF6638" modified="2023-02-22" version="1">MADSKGPTIENVMAKITDEDIKKLAIFVAVKADIERHVQDVNFQPLIHIVDESLRGRSMPWNLMQTHIHIKTTEFVKNTTLNERFMKQVEQVLVSEDYHIELERILIPIIAELTGHYPDKEHEVVDMEVSNGSSPECDKFPVHTSTIPLPPGPPPFPPNFYSGQFSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0I3</accession>
    <name>A0A914Y0I3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y0I3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1272.t1">
        <property type="protein sequence ID" value="PSU_v2.g1272.t1"/>
        <property type="gene ID" value="PSU_v2.g1272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF347">
        <property type="entry name" value="PROTEIN KINASE C DELTA TYPE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1272.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13949" checksum="A6B8630D3B54912A" modified="2023-02-22" version="1">MALDKSLKHYLKNHAYGVDQTETEEYMNNLWSGGDGPVKKYKLQHFNILKVLGKGSFGKVLLVELKGSSRFFAMKCLKKDVILEDDDTECTFIERRVLILSSECPFLCQMFCLFLSFFLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2L2</accession>
    <name>A0A914Y2L2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome-associated inhibitor A</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPF/YfiA ribosome-associated protein family. YfiA subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2L2"/>
    <dbReference type="SMR" id="A0A914Y2L2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13688.t1">
        <property type="protein sequence ID" value="PSU_v2.g13688.t1"/>
        <property type="gene ID" value="PSU_v2.g13688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.100:FF:000002">
        <property type="entry name" value="Ribosome-associated translation inhibitor RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="entry name" value="Ribosome hibernation promotion factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050574">
        <property type="entry name" value="HPF/YfiA_ribosome-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007654">
        <property type="entry name" value="PRK10324.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33231">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33231:SF3">
        <property type="entry name" value="RIBOSOME-ASSOCIATED INHIBITOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="Ribosome binding protein Y (YfiA homologue)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13688.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12785" checksum="562901F819836A87" modified="2023-02-22" version="1">MTMNITSKQMEITPAIRQHVADRLAKLEKWQTHLINPHIILSKEPQGFVADATINTPNGVLVASGKHEDMYTAINELINKLERQLNKLQHKGEARRAATSVKDANFVEEVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2R6</accession>
    <name>A0A914Y2R6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2R6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13535.t1">
        <property type="protein sequence ID" value="PSU_v2.g13535.t1"/>
        <property type="gene ID" value="PSU_v2.g13535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13535.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9341" checksum="477EBF5B4E97588F" modified="2023-02-22" version="1">MARIVEELLKNFGISIDKIFLILRDGASAVVKLCNLLGIDSSHCFAHLLQLAINDALKIVTSFDELLKKIKKVTSTKIEKKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Y8</accession>
    <name>A0A914Y4Y8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Y8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15263.t1">
        <property type="protein sequence ID" value="PSU_v2.g15263.t1"/>
        <property type="gene ID" value="PSU_v2.g15263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15263.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8197" checksum="5002586339238F75" modified="2023-02-22" version="1">MKSRNSIPTFSGKNRNPLKTQPKMVQKRKKAESAKHAKTNIGAGLYAGEDCPKPRIAKRFHENATRDADLAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y525</accession>
    <name>A0A914Y525_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y525"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15300.t1">
        <property type="protein sequence ID" value="PSU_v2.g15300.t1"/>
        <property type="gene ID" value="PSU_v2.g15300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15300.t1"/>
        </source>
    </evidence>
    <sequence length="521" mass="59509" checksum="7344E5787ADC7B00" modified="2023-02-22" version="1">MMMAMEERNAIIGAVVLNNSFFLTCNFTEPEDFHIDIPNIIKDVKSPSKFFQELSTLFPLKRIKAIVMVLMDFTNPSLQLQSAFKQRYWDICKQNGIYFYSPSLVPASLFCALFATQTLVNDGEYVIIVNSDVGCTHRNVVKRIDGKYKLHEAGLIDVPTNRKLLKERILGSFKSSKVILMTIFPNDVKRNSDELNRLMTIKNSLKGCSFEVMKKCFMENILEVATALYQHLVDEKKSEFFITPGCFEMIGANYNKKWIIKADGTTLLPFEESVIIDFVRQNKFIDSGVSLYGNIESNLSCLEKLYFKTKKAKVTLKIDINMIYDFKVEEYVVDSETSDITEKLGKNLNIKNPVEKAKIIFGKNDFSIMIWEKGSMKTLKDSNGFTKIPYYIAFDEEIPVFGEAAKEVLKTKPTFVVYDLLKLSCMENVNEKDSIWPFNVTKNAEGDIMVDFDTFRGRRKTRPGFLLALLVKYCLKLITDETGGDLLTDLEVGFNGLDTENKLIFNILEAAKTSKINLLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5P1</accession>
    <name>A0A914Y5P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5P1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14084.t1">
        <property type="protein sequence ID" value="PSU_v2.g14084.t1"/>
        <property type="gene ID" value="PSU_v2.g14084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14084.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21629" checksum="23C315BCEF3EBD82" modified="2023-02-22" version="1">MIKGVSLSGFLIKNDFDSKSKDDSRLSDKYDKTLNPFSTEYLNVFESQKKQKQKDSSAINRSTLSLHIAAYENSVEAAATDDKKQLLLLSSESSTKKTANICGKTWKGVKQLFSNSSSSMGAFEIPRQQNEDKVSEPEIMHFKSSQKLLNPNEEKATLKTKDERKKDKEKNEFEKLKEEANKLFKVNFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5Q6</accession>
    <name>A0A914Y5Q6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5Q6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14575.t1">
        <property type="protein sequence ID" value="PSU_v2.g14575.t1"/>
        <property type="gene ID" value="PSU_v2.g14575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14575.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38325" checksum="6317A9F8036B8FCE" modified="2023-02-22" version="1">MALRCVSSQWTITVSPDSFVHQYDVDIVFGRPETINDENGRGVKKLSKSNNAISKSICRQIVQGLPELNGIIYVYNDRAILLTNKPLKDDIKVTISQSNLDESLRKILISRESVLKIAITKTKTIKLSDFPIDAASTLKEDRTWRTLIEMIISEDAVTRVNDKYIPIDGAICENKFTNFCCGLIYRNGVKKGVEVIELDNRPQLALTMDYCCKFLYPGGIIFLDLIKRFMSENGTYKDAEAFFKNIKLCPTYDRSRILIFYKFTEKSMRFLKTQNGGTLEEYYRSWNIRLRYLDEPAAITNGYGDFPLELLEVLANQSVSIGKMPGGSISRKRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y667</accession>
    <name>A0A914Y667_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CYRIA/CYRIB Rac1 binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYRI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y667"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15689.t1">
        <property type="protein sequence ID" value="PSU_v2.g15689.t1"/>
        <property type="gene ID" value="PSU_v2.g15689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039789">
        <property type="entry name" value="CYRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12422">
        <property type="entry name" value="GH09096P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="5">
        <location>
            <begin position="30"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15689.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37582" checksum="C24082137E34DA30" modified="2023-02-22" version="1">MPTISTGCTDTILALLRTNNTNYDLYKSIDVFLDVEHINPTADEKQACEMVTNFLIRSEEVIKYLQDYKNGALNEMKHAFENPDKPEIQQQAFELLQHSFDQTKKCLEVAAHLKQIVPCILWSMVKGPLPLVEQLNVCQALCCQFSLIIDFVHRFDELKMNTPNVINDISFYRRMMNRADSVAQCSQSYNIEEGNEVLFFFSEPTPMLKALVDSTKTFVANAELKIENTVDTLTCFVSVCRQMLERKSNVEKLSANSQNFFTRVLVGAFILLDHTDPNGAFCRQSPIDVKSLVTVIKMNSTESEGLLSAMKFTSKNFNNPKTPKAIKALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7S8</accession>
    <name>A0A914Y7S8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7S8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15509.t1">
        <property type="protein sequence ID" value="PSU_v2.g15509.t1"/>
        <property type="gene ID" value="PSU_v2.g15509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20177">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047462">
        <property type="entry name" value="Dpy19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF1">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15509.t1"/>
        </source>
    </evidence>
    <sequence length="691" mass="79713" checksum="1BC784A2D9530301" modified="2023-02-22" version="1">MARQKTAPPAPEIPKSTASSSYSFLNSIFIVLAVIVLWIYHFRHLSTLFENDRQFSHLADFEREMTYRTEMGLYYSYYKTIINAKTFTQGVIEIMYDNKTEYGHTINTLERFNLYPEVVLAALYRTFTTITKNLGMITQNCYIINRGDDLSPVESCEGIGNPHYFYISGAFFIAGSVLPSMYLLGYLLSDSHIGGFMSAAAFMFNHGEATRVQWTPPLRETFGYPLFLAHIVTVTYILKHGTNIGIYFFSMILNACFLLSWQFAQFALFTQLAALYAAYMLEYISLSALRPLFRSYLAPFVVAYCLLFGNRMLLSSLYFTSIVAINIALILRPVLNRIQTRPLYILVHIIVYVFATFGTKALVKYVFTIHDDDHVFDILRSKFTEYANFHTKLYTCAAEFDFLGPEYIKKLSQTALLPFSVLAACLILFMLLRWEIFTAMFWYRNPEHSNHGKPFAELVYHFGQFAFFALMAGLIMRLKLFLTPELCALVAILFNKKLFLMLFNFRPTMWRIPLAVAIFACMAYKGMKNIEEQRSITGSYSNIEQENLFNWITENTRTDAVFAGSMPVMANLKLSTDRPIANHPHYEHEEIRNRTLKIYSLYSRKSLKEVHQTLKNMGINYYVFQPSSCTGQHPKPNCTYIEMWDMEDPKNIGNPSLCDIFGIALGRREYSKIKPFKVVYTSSAYIILELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7Y2</accession>
    <name>A0A914Y7Y2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Extended synaptotagmin-2</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the extended synaptotagmin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7Y2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14858.t1">
        <property type="protein sequence ID" value="PSU_v2.g14858.t1"/>
        <property type="gene ID" value="PSU_v2.g14858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008429">
        <property type="term" value="F:phosphatidylethanolamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08391">
        <property type="entry name" value="C2A_C2C_Synaptotagmin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04050">
        <property type="entry name" value="C2B_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21670">
        <property type="entry name" value="SMP_ESyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000025">
        <property type="entry name" value="Extended synaptotagmin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037733">
        <property type="entry name" value="Ext_Synaptotagmin_C2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037749">
        <property type="entry name" value="Ext_Synaptotagmin_C2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF1">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="17">
        <location>
            <begin position="104"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="281"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="428"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="679"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14858.t1"/>
        </source>
    </evidence>
    <sequence length="816" mass="92372" checksum="ECF55D48E3D4F8FA" modified="2023-02-22" version="1">MPSILDPSTEELQTKELIMSWQNYIVPISCSVALMALCWGVGYYNLSFLWIILFSILYILKQHMWMKRENKRLRLRQFISQEREAIMAQFAQNDDLPAWVQFPDTERIEWVNKVIHQLWPYIGEYAKQFMVEFIEPQVRAQMPSPFKSFKFTKIDMGDLPTRVGGLKVYTKNVGRDRILVDMDVVYAGDAEFSVKTCGFSGGMNQIVLTGKVRCVLMPLLPYPPMVGGISGSFIELPKFDFNLTGMGEFVQLPGLIDAIRSVVNAQIANLCVLPNKIVMPLAPNVDITKLYFPEPDGIVRLKIIEARNLENKDFSILRKDKSDPYCEIQVGAQIFKTKTINNDLNPVFNEYFEAVVDQASGQTLRIDLFDEDSTGKDEELGRLSLPLEIVRRDGVVQKWFHLEGCKHGELHIKVQWFDLANDKNSLGKQAWDDEWLTADKPVHPAMVMVYVDTVSDLPYPKAGLEPSPYVEVSLGRAIQRTHVREKTVNPLYQSKFTFFVKQPEGQNLHFAAVDDGTKRPLGELEIPLLSVINQPEMEFFQQTQYLTLGIHTSPVVLTIRLRAFKPTKGTHSEVLDFDQTAKSYGTASHIERAERRTVAPGKSVPSNGTLNVAIPAEPGKTVEANGDPDVSALKLEANNTLSASSPSIAESSLSQATDHTLMSKFKRPKHSKKKLDKHDRAQLHINLHYNADRFKLVVDIIQAKDITPVEKNGNVSPYVKIKLVPLTGGSEKATRKTPVIRNTTNPHFDNTFEFDVHYSDLKNYKLRFAVKDDLNYGVLHRPPVLGYCDVPLDEFDHEKPLTDHWLVLTPGGRTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8M7</accession>
    <name>A0A914Y8M7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8M7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15622.t1">
        <property type="protein sequence ID" value="PSU_v2.g15622.t1"/>
        <property type="gene ID" value="PSU_v2.g15622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15622.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21401" checksum="C377D9C1CCA9AEB2" modified="2023-02-22" version="1">MQLRAYTTINGSKPTRSLVLFSFERGTVSDLCAFIAEKFFCPFGSTFSVSVKSALEPGGDPAFYKVTPDVVLEDASEMSVVVELPTSDPAAFQLSQSVSQLQLLAHLHSSQMFPGATGTAVVTETPSDDAQFLEQVTAIFSTNTSSDPDEPPEKAASYSTLLHAVYLSQRQAVDESYVAMKPANPVLLCHVMVLLFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8U6</accession>
    <name>A0A914Y8U6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease</fullName>
            <ecNumber evidence="9">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y8U6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16613.t1">
        <property type="protein sequence ID" value="PSU_v2.g16613.t1"/>
        <property type="gene ID" value="PSU_v2.g16613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="11">
        <location>
            <begin position="100"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16613.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22451" checksum="44796BFCA10FACF6" modified="2023-02-22" version="1">MHSVHRKNDMKKLSQIAVTATIATGSFIVGHYYNDLNEYFPSFLPIKNASAATALISAERTSPTLDMPSSKTTVEPWVQPSRAAEIMKWGWPGFDNLRTYEDFVLSYDRRTRTAHWVIEHLTPDRMTYDASVDRGKCAFMPDNSIHEYFRSTNEDYFRSGYDRGHLAPAGNHRKTQNAINQTFYLTNMSPQVGKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y939</accession>
    <name>A0A914Y939_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y939"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15959.t1">
        <property type="protein sequence ID" value="PSU_v2.g15959.t1"/>
        <property type="gene ID" value="PSU_v2.g15959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15959.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19379" checksum="A9CE258637CE1A35" modified="2023-02-22" version="1">MAHKITLRSSIDPKFSIEVDDRVIQSCTILRNVQEHTNDDGEVDVDMTQRQLQNFVDLHNHFPSADAPKDLEWTNNFFREMPETEFKELCWKADYLDSQRFLEAAGDFVLNQMENFDVPEIQSYLNVVDDYTPEERRAMEEHPLEFFTGVSIQNDDNAPSTSGEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9P4</accession>
    <name>A0A914Y9P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9P4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14258.t1">
        <property type="protein sequence ID" value="PSU_v2.g14258.t1"/>
        <property type="gene ID" value="PSU_v2.g14258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14258.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8148" checksum="EEA3189BBF551D34" modified="2023-02-22" version="1">MKLGDLGFYFGEPKPQKDYMNMLIERMKKLRVLGDLPPVFPNGWYCIAESSELKPKQIKPVIFMVNSKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB01</accession>
    <name>A0A914YB01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15945.t1">
        <property type="protein sequence ID" value="PSU_v2.g15945.t1"/>
        <property type="gene ID" value="PSU_v2.g15945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="297"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15945.t1"/>
        </source>
    </evidence>
    <sequence length="604" mass="69018" checksum="ECE2E436F784C7D1" modified="2023-02-22" version="1">MCTCHIKERASIVRHVRSEDNPADIGSRGCMIDELVKSKLWWHGPNFLQLPEDKWPKEAVMAVDFAKQHINNDLPEDEISIIMDKNSKVPKLTSSLKVAAKSITVADKVESLCVEIDSTRFSKWSKLLMSHSAVLYALYKFGKSAANPSNLFEKLLKLKVNSHQQPSLIMEAEVNLIKQLQQKCPPTVNVQRNLMLKLNQAGLIVCNHRIAATEKTPDLIWLPDCYEVHLLILHIHAKLFHAGPRETLNELRSLYWLCQGKRITSKVINNECQKCKLLKLKPYKMPVMPELPCERTTASAPFKHCGLDYAGPKMIKVDSETKKCWIILFTCFSTRAIHLEVVKGLDAHNFILAFRRFTARRGRPDLIVSDNQSTLKAASTLIEPCWHQNEGELQDFIARERLSWKFIIECAPWMGGFYERLIGLTKKAISHAIGNRILTFDEFNTVVIECETIVNCRPISPVDPEFKPGQAKQLALRPVDFLMPHGNINNGLPYYCFDNDPDFLPKETTGDTLMRLMHKTAAIVERFWKIWSIEYINQLREVNQNFHRQNKIADAAPEIGQVVMIKEENAIRNTWKLGIIEELNSSKDKAIRSAKVKTPNAFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBI3</accession>
    <name>A0A914YBI3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBI3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16779.t1">
        <property type="protein sequence ID" value="PSU_v2.g16779.t1"/>
        <property type="gene ID" value="PSU_v2.g16779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16779.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15017" checksum="D67E4DC64BE4CF7C" modified="2023-02-22" version="1">MNCTEGWFYFEPTHSCYGHDGYNYRYGHWADAEQYCESVNAHLISLHSYDETRFLTTVISFTGGVPWTGLTSNDNEVSWKWSDGSPFDYRPWASGHPYRNVSSCAYLYLNGLYDVDCISNYNFVCKKPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBR6</accession>
    <name>A0A914YBR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaminase EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBR6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16864.t1">
        <property type="protein sequence ID" value="PSU_v2.g16864.t1"/>
        <property type="gene ID" value="PSU_v2.g16864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041541">
        <property type="entry name" value="Glutaminase_EF-hand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17959">
        <property type="entry name" value="EF-hand_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminase EF-hand" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16864.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10424" checksum="40F88D113A4ED701" modified="2023-02-22" version="1">MSKTAEALSKSYEYKTTSAEDLVFDLFKAQGPKEEASIGKLLSVLRSFGLKEDDPRLKNTMDKIRDYDLMNEEDNDVRHYRLNRNQFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBV2</accession>
    <name>A0A914YBV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA/RNA-binding protein Kin17 WH-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBV2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16767.t1">
        <property type="protein sequence ID" value="PSU_v2.g16767.t1"/>
        <property type="gene ID" value="PSU_v2.g16767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000021">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041330">
        <property type="entry name" value="KN17_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041995">
        <property type="entry name" value="KOW_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18131">
        <property type="entry name" value="KN17_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25092">
        <property type="entry name" value="SH3_KIN17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Kin17 WH-like" evidence="7">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16767.t1"/>
        </source>
    </evidence>
    <sequence length="391" mass="45265" checksum="2E2B0F59B2A8FBFB" modified="2023-02-22" version="1">MPRAEKGSAKAIANKVKSKGLQKLKWFCQMCNKQCRDQNGFKCHLTSESHQRQLLLFAENQNSYLREFSREFESSFMRILRHQFGSKRIRANEVYQEVIKDKGHIHMNSTVWHTLTGFILYLGSSGKCKIDQGEKGWYIQYIDQEEELRRNKIVQRAKKEKDEEDRNNDLLERQINRALEKEKETGVEDEEPVQRDLIRENDDEKIKISLAPRSLVKPENEKVELKATKVFETADEKGSSNSMKRPSSSKSEASSSKKSALDKIMEEEERYKERKNRKDYWLHEGIIVKVVTKKLGSEYYKAKGEIVELVDKYTAKVDVDGDILKLDQGHLETVIPAVGKDMLIVNGGYRGTKAILLEIKERDYCLLLKLKEGLKHGREVTVAYEDASKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCR0</accession>
    <name>A0A914YCR0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase metallopeptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCR0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15251.t1">
        <property type="protein sequence ID" value="PSU_v2.g15251.t1"/>
        <property type="gene ID" value="PSU_v2.g15251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF329">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036790385" evidence="8">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="9">
        <location>
            <begin position="58"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15251.t1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26560" checksum="8F4F1A61510922BD" modified="2023-02-22" version="1">MYFIVFFSLLISSTHGFHLRDYILDINKESNVKRQAVDESKIRFSCGVSDFQGVKLRDTVPWQNDRVTYMVLIESKKLSQDIVRRTLRQAFDIWSAEIPREFVEVNDESSADIKIGFVTGKHCDMEPFAKNSNVFAHANPSGVLHFNDDIPWKSYSNADNIELKSIDFFWVALHELGHVLGLAHNTKVPKSVMENIYKHPADQKGRYREPRLIPEDVDDIREIYGARIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDK7</accession>
    <name>A0A914YDK7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16836.t1">
        <property type="protein sequence ID" value="PSU_v2.g16836.t1"/>
        <property type="gene ID" value="PSU_v2.g16836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16836.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14480" checksum="192D5B77EB3373F4" modified="2023-02-22" version="1">MNGTSSAQIESVELCLSNMPDEFLPYFIFYMVGFGFIIPGFIIALCYIFLIRHLRNKNGKNMFVTAYTGRVVRSILKVVIFHFICWSPFWLFVILPILPKYFEEYDWSILLSPYVDKLRMSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEG2</accession>
    <name>A0A914YEG2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEG2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17688.t1">
        <property type="protein sequence ID" value="PSU_v2.g17688.t1"/>
        <property type="gene ID" value="PSU_v2.g17688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17688.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21437" checksum="6CE69C9636D72DCD" modified="2023-02-22" version="1">MESSRRRQSQFRADNLLLAIRPTLQKGYKTGGVCFAQICISLFITCIGLIEGFHAQRTISGLICFQYSIFFGLLWILHFFGWKYNSPRLLIAHTVACALLAISSLLFVLLILFSDIYNGAIMNFPPIRHQIQVAIIEALSSLPLFVIFGASSWNHAERGRNYSDKRRRFLFAMKALESYILQKVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEQ6</accession>
    <name>A0A914YEQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15873.t1">
        <property type="protein sequence ID" value="PSU_v2.g15873.t1"/>
        <property type="gene ID" value="PSU_v2.g15873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAMP" evidence="1">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15873.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13816" checksum="9871B05448C4615A" modified="2023-02-22" version="1">MDQTLLGNLKAHGVARRPMQYGDAQFAQVVSTIRNEGGDTVGYVVEWRDRTQEAQVEAEVARVIAQAAAGDLSGRIDATDKEGFFLQLAQQINGLLDANAGSIEQISGLLAALSQGDLTVRMHGDYQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEY0</accession>
    <name>A0A914YEY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEY0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15941.t1">
        <property type="protein sequence ID" value="PSU_v2.g15941.t1"/>
        <property type="gene ID" value="PSU_v2.g15941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765294" evidence="1">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15941.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="11021" checksum="7F6123D6FA4A2DE8" modified="2023-02-22" version="1">MFAKLFIFFCLILALFEMTSAQLGGHHHGGHMGGGGIGHGGIGGGHMGGGHMGGGHMGAGHMGGGHMGGGHMGGAGLGGHHGGGIGGGHMGGLGHGGIGGGRMGGGGIGGAIHQAAHALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFL7</accession>
    <name>A0A914YFL7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFL7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16155.t1">
        <property type="protein sequence ID" value="PSU_v2.g16155.t1"/>
        <property type="gene ID" value="PSU_v2.g16155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16155.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17801" checksum="3AD67A31A506124B" modified="2023-02-22" version="1">MPGGTSNNTAADAPDDTQKSLATKNIGIPIVQLQENKVVDKSSSSSQWITEVPTRSSSEFSDPTGFSSFVTTKESKLTSLKSSELSETQSKQKHRKKSSSDQTSESSVSDTSEDHPSLPRLNLTQEDYSNQIATDKKWQEAVNVFLQHDPVAKTPRRRTVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGG9</accession>
    <name>A0A914YGG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IRG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGG9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16434.t1">
        <property type="protein sequence ID" value="PSU_v2.g16434.t1"/>
        <property type="gene ID" value="PSU_v2.g16434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143:SF1">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="2">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16434.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11473" checksum="42B2CD7CE8A093DF" modified="2023-02-22" version="1">MAKEAARLKHNIDTKYMNFGFAGHSKTGKSSLINSLRGLKNNAEFAAGVDTIEKTHKVQMYPFTEAEFKMIRLYDIPGCGTVTHKTDGYYMIFLLFCFFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGH5</accession>
    <name>A0A914YGH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TMC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGH5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17885.t1">
        <property type="protein sequence ID" value="PSU_v2.g17885.t1"/>
        <property type="gene ID" value="PSU_v2.g17885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF40">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17885.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36285" checksum="23EAFFC85E694FF4" modified="2023-02-22" version="1">MENWHPRLALRLHLARVLVLYILNYCTFIYVLYEKYATNAYDLKNEFSNDEVDNNNNNNNLDQARSRRQLGGRNPNIDRPPPFASRNFVNRTQVIQFLNRTTKKLPDGFGTTKRPNIISKTDAVTVRSQFGPIGVNNPTVLVRNATLSPSQRRFETRRLGPPPLPVFSPPPPRVRPKDGQIYKGQQFGPDWENIGSEEDPNYVRRRPPYGSKGEKEVKLPSENELSKNSTSNDTVTGEQAKISTKEFFNQNICWETMVGQEIVKLVTIDLYITIGSILVIDFLRGLWIKYCSSWWCWDIETVFVSISRDFNYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGJ6</accession>
    <name>A0A914YGJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGJ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18577.t1">
        <property type="protein sequence ID" value="PSU_v2.g18577.t1"/>
        <property type="gene ID" value="PSU_v2.g18577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="872"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18577.t1"/>
        </source>
    </evidence>
    <sequence length="1165" mass="134780" checksum="A38074873D14A1EC" modified="2023-02-22" version="1">MSFLQYFQRKNLESKQPPNVQALQGEKRELQIALEREESEKHELFMQINKLIAELADLRGNAAENAAAKDLKQEIDQLRGKLQIAEHERDEIKRSISLLEAEKNSAKEELFVVNNELEKIKVNAETEKQKLRQEIELHQKEVQVKSAALQSLKLAKASEPSTSAEEFDRVIQEKNQISHELETKKKELTELSRSENDKQKALEISEAKIKQLEKDLEEFRHNVETIQKELSQKSHEIEEYKSQMVSSSTSASAKVHEIQEKYENSQRKISQLEQSLEMATKNGNEIEQEAAEIEERLAQAEDTIDELNKEIQRMKESGKSDELRISSELQIAKEAISNRDKEIEVEGKKIKEMEDSMKKLREEVDNYKNEIVSLNEDLQKRSSEITQSTSTIHELQTRISQLEKENNKLMEKASVEEELMTLVNSLQEARARISGKENEIHELRQRLNDQQDETDKVSSELRQTLSALERAEEECKKFAETDVELAEYRRESEKRLEEVRRELNEEIVKAKSEANKLQNELESSKRTITKMENEIKDLANLGETRLEKLRAVEIEKGRLETKIVEYESEIESTEDELSRLRQNQSEASQNAEKELAKIREALKIAEKSLESNKAEMQKLEVELREAHSKEASHAKESTEAKNQISALETSLSQIKSEKEQLKKELLEVESQHETYRKQSEDFKTLITSLEGKIAQIQTEKDQLESELREAESRHIVYSKEGADFKTLITTLESTVSQLKSEKRELESDLSQARSREEVHSKEGADSKSLITNLEVKIAQIQSEKNQLEAEVHETQKRYHGTESSKDSEITQLKSELASKDSQLQQLSNTALELDVIRSSLNEQHSKMGVMEQEKTILADKLQEVKNALERKQEELEAEQAASASKMGNRESELKSDLERIKREKETLEIELNNQKELVTDLKRSHDRLNENLERFSELMAADGKRFDTVTKEKEMLFQEKQILADNLRRTEERIKIYESEIEDLKAASSTPPLGDEAELRRKISELTEENARLAGDLLKQSGKDDATQFRGEFERALQEKQRGWQQEKQSLIQKLEEQENDIQKLHQSKVDLETDLQRIKLSYNDTLTPVPKPRRANTSLTNLTMDTYSERSITPSADEEEVRKLRGELDKQKRIVTVLRKKLQQQQVETLRQNKMNTSSTASFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGX6</accession>
    <name>A0A914YGX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGX6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19561.t1">
        <property type="protein sequence ID" value="PSU_v2.g19561.t1"/>
        <property type="gene ID" value="PSU_v2.g19561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037966845" evidence="1">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="190"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19561.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34358" checksum="5FF9A2E5861DA379" modified="2023-02-22" version="1">MRLLLTFLSFFVGTFAACPNDGIEWQSVCYYFQGNISAFVNAEEACIHLGGHLASIHNGFTNAFIAQQASLLLHSSTIADIWIGATDLMNPDTWTWTDGSNFTFIDWSQNKSASGEDCGSLNLSEGFWQAQDCFKQKAYVCAINERVNANTSTSTTTTTTTTTTTQKTVTVPSFYDCGWDWIYFPPTHSCYGALTKISWNDAESYCEDHNSHLISIHNSLEYRFVGTLRDIIDDDLWLGLVSYNSGNDWKWTDGTSMNNEYWADDYPKTGSNLCGYMWKDLHWYNDRWCSNSVKVMCKKTVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHE3</accession>
    <name>A0A914YHE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YHE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16728.t1">
        <property type="protein sequence ID" value="PSU_v2.g16728.t1"/>
        <property type="gene ID" value="PSU_v2.g16728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16728.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17583" checksum="F10C07A3054B4A43" modified="2023-02-22" version="1">MSRLSEPYGSCTNDKPDGYLFDRNYSTEGCQRTRYQAQMVSNCQCYDPHFPPPKNSTETKPCTVKDNFDCWLQESNVTTSDNACTQPCNEGVYDVTVSSAKWPSGSIKTVGKCEEGMYGNTTCLGIFKQNGALVEVFYEKLNYETMEESASYTVGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHG9</accession>
    <name>A0A914YHG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHG9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18916.t1">
        <property type="protein sequence ID" value="PSU_v2.g18916.t1"/>
        <property type="gene ID" value="PSU_v2.g18916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18916.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8534" checksum="B07B66D16B0649DE" modified="2023-02-22" version="1">MQCASIAKGKCFIGHTPDECCPICVGCLDDQNGKREIDENWQKDECTNCTCNVNFTTTCITPICKTDCINPRKVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHT8</accession>
    <name>A0A914YHT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18886.t1">
        <property type="protein sequence ID" value="PSU_v2.g18886.t1"/>
        <property type="gene ID" value="PSU_v2.g18886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF4">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18886.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19814" checksum="DBC3274C0DAAC401" modified="2023-02-22" version="1">MIYLSSLGETKEAPFAHLLKDAEGNMSIVAEFVKNIFGKSDITYPSLLLLGIDKLPPLDPETQKFLESSRDQLRREINDLLKDDGILIFPSWPSLPPFHNKPLASWWSFMYTGIWNALRLPAIICPMGLNENGLPLTVQLIAGHDNERLLIAAANDLEEGFGGWRPNHAPKHHYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJR3</accession>
    <name>A0A914YJR3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2058.t1">
        <property type="protein sequence ID" value="PSU_v2.g2058.t1"/>
        <property type="gene ID" value="PSU_v2.g2058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF20">
        <property type="entry name" value="BESTROPHIN HOMOLOG 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2058.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13602" checksum="6FB717C492B2E6AB" modified="2023-02-22" version="1">MTITYNLDAPHLIFKGVLSILFRWRGSVWRAISIPLLSWLIAYYLVFCIYFFLLRPYDKYVFDKVTEVFEKKLDQFIPMTFILGFFVSSVLGRWQECLKNIGWIDRVSKNNGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKQ9</accession>
    <name>A0A914YKQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNF-p1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKQ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1993.t1">
        <property type="protein sequence ID" value="PSU_v2.g1993.t1"/>
        <property type="gene ID" value="PSU_v2.g1993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044866">
        <property type="entry name" value="HNF_P1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51937">
        <property type="entry name" value="HNF_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNF-p1" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1993.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11279" checksum="C36C5EBA968E36BF" modified="2023-02-22" version="1">MNVSLSNLSGSSCILPSPIGTLSSGTIAESSIQPQSSIPTSPISTGTMTTGSLLQQLSNASFVNPAMAAAAAAAASVNHLLPLPSPLFTVEQLELIRRLRMTGISADAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL94</accession>
    <name>A0A914YL94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solute carrier family 35 member F6</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL94"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20316.t1">
        <property type="protein sequence ID" value="PSU_v2.g20316.t1"/>
        <property type="gene ID" value="PSU_v2.g20316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20316.t1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42751" checksum="560EDE3F96295082" modified="2023-02-22" version="1">MVVIVRNRKMTDDLHRKRVVNLMIAVLMVVTGSLNTIAAKWADSIKVDNTTFNHPFFQAICMFIGEFCCLIAFFIIYVVQKVSWRRRNIEGEGGIVAELDGDVEPTIPKFNVFIFLPPAICDIMGTSLMYIGLNLTSASSYQMLRGMSIVTAGLVVVGVSDIVFDDRPTDDTNGIITGNLLIIMAQIIVAIQMVTEQKYLTQYDVPALLAVGLEGLFGMIILSVLLIPMYYIHVPSTFSSNPYGRLEDIFFAFKEIGDNPTILAALALTIVSIAFFNFAGVTVTKRLSATSRMVLDSVRTLVIWIISIPLFGEQFIAIQLLGFALLLVGMFVYNDLIFGPVFRQKVLPKIENNSLSLCCASFCGADIEVADRESLLDDDDVEHMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMI7</accession>
    <name>A0A914YMI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMI7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20143.t1">
        <property type="protein sequence ID" value="PSU_v2.g20143.t1"/>
        <property type="gene ID" value="PSU_v2.g20143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20143.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17040" checksum="A1D53656338967FF" modified="2023-02-22" version="1">MRTELQSAIVEEIQKITEKDSGHLFEIQSLEILPDDHRFLTVLDYLERIMKERDDYANGILEMAQNNNRSDLDEYENVSNGTTTSSSSTNGDCPSTTATTTTTTLINGNGKMYKEVQYITRSPSPSTQERHGNIEVAELKAQVRRLKYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMP2</accession>
    <name>A0A914YMP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMP2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20659.t1">
        <property type="protein sequence ID" value="PSU_v2.g20659.t1"/>
        <property type="gene ID" value="PSU_v2.g20659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF5">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20659.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17381" checksum="C58DDE441C42DBC2" modified="2023-02-22" version="1">MMSTEAGNLMPLSSRARGEMPSVRRIYLIRNGESCDRLCPEWRHKVFRDDGIYRCIDLNQPSKIIARSSPDLFRNDTPLTQIGSVSSQLLGRGMLMKSAGVHTIYSSPAFRCIQTASAIIGNLNMKKTPKIFVEPSLIDPLSFYSQVKTDYRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPE4</accession>
    <name>A0A914YPE4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YPE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21308.t1">
        <property type="protein sequence ID" value="PSU_v2.g21308.t1"/>
        <property type="gene ID" value="PSU_v2.g21308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="51"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21308.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36450" checksum="79BF2EE1A2FA21A3" modified="2023-02-22" version="1">MLLNKHHRKIESIFRCFHKVSTRISDQSYVHGASEIPLLNNTVADRFRIALEKGSDKLMVIFKEDGIRKSYQQVFDDARQLAASLINLNLKKGDRIGIWGPNYYEWVVTKYAAALSGFILVNINPAYKADELKFALQKVGVSAILSPIKYKTCNYYRTLTEVIPKMLKGQDGIGKVHCKDLPELKHVILFKTDKRFQGAWNFDELIQTPGSEAFKLLDEYESKIRVDDPFNIQFTSGTTGRPKAATLSHHNVVNNAYFIGLRAGFDRNREKLIIPVPLSHAFGFVIGLLNAVCHHQTVIFPSPSFNAKSVLEAINDEKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPY0</accession>
    <name>A0A914YPY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPY0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19420.t1">
        <property type="protein sequence ID" value="PSU_v2.g19420.t1"/>
        <property type="gene ID" value="PSU_v2.g19420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19420.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26079" checksum="2CD958E042EEF7BD" modified="2023-02-22" version="1">MFDNPVTQPFMELIKIYVKSIATVLSQTSEFSVENVFENLPPVSKFQKCVDGKFLIVFKLKNGMFLEISTFLYDLFHQKFNIIQRIRALTDAIKMTRYMARLIETSFEAIGKYLNVENIKDFGKIDKYKSIFIRFRQYSIELKLLIEIIKSLAVKFDKHLLNSVQPFNAKSEDEENNMPSATTKLVVSCYANLRNNEYQSSLGALIVHCEFSSLIEIGLLKPEISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ60</accession>
    <name>A0A914YQ60_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ60"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21167.t1">
        <property type="protein sequence ID" value="PSU_v2.g21167.t1"/>
        <property type="gene ID" value="PSU_v2.g21167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21167.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15070" checksum="8942FD37593247AA" modified="2023-02-22" version="1">MARGHVLALEGEELATDREAGVVLRFRNARHLQQLQRGATGTDEHEAAVGGGLGAGLEVLHRHVPALVGVLPQRAHFVVQVQAEVRAALQAGGQLAGDHTEVDVGTERHPGRGDLLLRITALHQQRCHCLICAGSSEYCMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQA2</accession>
    <name>A0A914YQA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1954.t1">
        <property type="protein sequence ID" value="PSU_v2.g1954.t1"/>
        <property type="gene ID" value="PSU_v2.g1954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06579">
        <property type="entry name" value="TM_PBP1_transp_AraH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32196">
        <property type="entry name" value="ABC TRANSPORTER PERMEASE PROTEIN YPHD-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32196:SF32">
        <property type="entry name" value="XYLOSE TRANSPORT SYSTEM PERMEASE PROTEIN XYLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037710290" evidence="10">
        <location>
            <begin position="19"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1954.t1"/>
        </source>
    </evidence>
    <sequence length="362" mass="37884" checksum="FAFA5DCC28682D16" modified="2023-02-22" version="1">MIAAIIAIMLFFTWTTDGAYLSARNVSNLLRQTAITGILAVGMVFVIISAEIDLSVGSMMGLLGGVAAICDVWLGWPLPLTIIVTLVLGLLLGAWNGWWVAYRKVPSFIVTLAGMLAFRGILIGITNGTTVSPTSAAMSQIGQSYLPASTGFIIGALGLMAFVGWQWRGRMRRQALGLQSPASTAVVGRQALTAIIVLGAIWLLNDYRGVPTPVLLLTLLLLGGMFMETRTAFGRRIYAIGGNLEAARLSGINVERTKLAVFAINGLMVAIAGLILSSRLGAGSPSAGNIAELDAIAACVIGGTSLAGGVGSVAGAVMGAFIMASLDNGMSMMDVPTFWQYIVKGAILLLAVWMDSATKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQS7</accession>
    <name>A0A914YQS7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQS7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2374.t1">
        <property type="protein sequence ID" value="PSU_v2.g2374.t1"/>
        <property type="gene ID" value="PSU_v2.g2374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF12">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2374.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16289" checksum="12F8C8082995E0C6" modified="2023-02-22" version="1">MLAPSKIFFWADDDSYVFLDNLRHYLTKFDPSQPHYLGFRFRPYLKHGYNSGGVYVLSKAAVKLFIQKSYLNSTLCPYMEFEDVAMAKCLESIGILPVDTRDEKGRQRFTPYDVDQMFAGALSEELSRIWFMDKPNEVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRD0</accession>
    <name>A0A914YRD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRD0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2569.t1">
        <property type="protein sequence ID" value="PSU_v2.g2569.t1"/>
        <property type="gene ID" value="PSU_v2.g2569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2569.t1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26090" checksum="D699EC30BEC03F3A" modified="2023-02-22" version="1">MFRLTILRFSITKNYIKNAANFINADKFVTDYNEHFPREILHKMKIKNDKIITFQKANLEIDKPLITNFFGLSDDDSLELMTMLTNGATDAIMAKDEGKFVGMATLNFIDGMTLLKKMPKRLEDYGSEIDNGPFKSRQANQVLSFVLASELLIPYRLKQQQQQQQEQPCKYMFGQVTQVHPKYHGNGIAKTMEMLSYFLAMRKNADHFVVSCSAEASAKMVGNMVSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRE5</accession>
    <name>A0A914YRE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THUMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3334.t1">
        <property type="protein sequence ID" value="PSU_v2.g3334.t1"/>
        <property type="gene ID" value="PSU_v2.g3334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="129"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3334.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32981" checksum="DB0CF37F1ECF2516" modified="2023-02-22" version="1">MSRPSNNQKRSNYYTQNQGYKTPKQLEWHKYGIWFTCEFEREGVREAQNIVSKFLNEPSVSEPAPVGGGGDASGEMDIADELKKQIEEANRPKNLKRIRQQPTGVKHCLFFTVADIPRAKIVDFVEKLVDECQKTQQCRYLLRVLPIEDISPSESGDLKTKLRQILKHHFDEFSSKSENEGKHATFAVDYKKRFSDQISRQQALDIVCEIVAEIDPESKVNLTQPDFTILFHVVRKAVLLGCLKNFNQKRKFALKVQEEKDEDGGSSPAKKKKEEEADEEGEEEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRF8</accession>
    <name>A0A914YRF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2763.t1">
        <property type="protein sequence ID" value="PSU_v2.g2763.t1"/>
        <property type="gene ID" value="PSU_v2.g2763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2763.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19034" checksum="4BA5D19CB3421790" modified="2023-02-22" version="1">MGDKSAFKLLIVLFAIFVGIYAGFATPDFAYSWTKGPRPLYLLDEKCYLIGESVIEAYKKNPNDFGSAFDVYSFYQKLLKYVKSRNDYYSVDPLHLMAYIYVAATVIFIFQHCALKCPKKNGFVFCVFFDAYFLSLLLIGFYKLLIFYDYFHTGANDCLRQIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS88</accession>
    <name>A0A914YS88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS88"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20260.t1">
        <property type="protein sequence ID" value="PSU_v2.g20260.t1"/>
        <property type="gene ID" value="PSU_v2.g20260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20260.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="25101" checksum="D02F6EE7733367A4" modified="2023-02-22" version="1">MPVATGLGQHRQRVGHPAQPVQHAGMAEHAGAAQRQAQHGAQVVLELRSLAAFDGPVAGVVHARRHLVGQQLTITAEQLQREHADVLQVFGNATGIADRCLPLGVGQHGRGHTGRQQAVDMPVAGDRPRLEAAIAAAHGDHADLALEGHEAFQDQSGALDLRAQRVPRGIDVGFVAQAELPLAVVAQAAVLEDARQAEFGGLRRQLVTAADVGEGRQRNAIAGQGFSLNRSWATASAAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTW6</accession>
    <name>A0A914YTW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTW6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4106.t1">
        <property type="protein sequence ID" value="PSU_v2.g4106.t1"/>
        <property type="gene ID" value="PSU_v2.g4106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007767">
        <property type="entry name" value="DUF684"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05075">
        <property type="entry name" value="DUF684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037631572" evidence="1">
        <location>
            <begin position="22"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4106.t1"/>
        </source>
    </evidence>
    <sequence length="561" mass="64862" checksum="D6B8E663B4BB43D1" modified="2023-02-22" version="1">MIFAKFITLFFVAALPFFVGSFVVPKTGSKVCEIGKVGADSVKDLAKHLSDFTIAITAASKLLPDGKTVRAVAGAVTTALLHEDVIKILSYIGPIGGMIGACLGVGKVVLDKKDEELKNAMFDLSKQLDSIVVHIDKSVIKILSHQDELQFQQLVTSPAKVLQGAFRDYLHSLHHEDLKTMKRLCKKNMPIQIFENMNTLLEKNSDNILASHYYTDLAFANLRIIYMTLFLELTPLHFVCEDLMHKPKDPPEDEQEKLRRRTKTIERKYIQISERFGAINARRAQDAWRVMPNRLNEWYGEYKKLKDGREFQHNFTRAVAEQLNEDYYNLGYDYAFGVAKNRPKYIHFACHETACHYKREKDFVVWVLRTKPCRNDTKTNMVTRASTCLQFEMLLYARFNAEFEYNNITAVTEMLQRNCRIRNIIGFASVRVKLNSSSAGEARKANIFPNSRNRVPYNILTERNHAVIRKSSFDDWQFWADCKNENREPFNFIDEYCTPESAWPTCRLKERAFQYHQLKNAEQLAMSMAPIPYVDTWAPEKERSMVATFNEDNKTIKKIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU29</accession>
    <name>A0A914YU29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-spectrin</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YU29"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3652.t1">
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        <property type="gene ID" value="PSU_v2.g3652"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
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        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
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        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
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    </dbReference>
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    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="316"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3652.t1"/>
        </source>
    </evidence>
    <sequence length="466" mass="54396" checksum="4B96B566A039795E" modified="2023-02-22" version="1">MQRKFDDFLKEVESNTYRYTDVNTAANKLVDEGHPDHEAVNNKREEVNNAWHRLSTLTTTRREGLFGAQQVQRFNRDTDELLSWIAEKETNLSSDDFGRDLNNVQALQRKHEGTERDLEALKGKMDKLERDADQLGHQYPDRRDQIDSKLQEAQQRWADLLRQAQRRKEDLNRSYNLHRFLADYRELSDWVKGMKALISANELAKDVAGAEALLESHQEHKGEIDARADSFAQTAEAGQKLLDDGVRESSDVRNYMNQLAEEKASLDNLWEERRILYEQCMDLQLFYRDTDQAETWMNKQEAFLANDDLGDSLDSVESLLKNHQNFEKSLAAQEEKIHALDEFATKLIEGQHYAANEVAKRREALLARRQQLMNKARDRNDRLKESYNLQAFDRDCDEMLGWINEKLKTAKDESYLDPTNIRGKLQKHQNFEQELRANRNRLDEIQGNGQSLINNAHFAQDHIQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU78</accession>
    <name>A0A914YU78_9BILA</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21021.t1">
        <property type="protein sequence ID" value="PSU_v2.g21021.t1"/>
        <property type="gene ID" value="PSU_v2.g21021"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
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        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21021.t1"/>
        </source>
    </evidence>
    <sequence length="254" mass="27551" checksum="7F8043CCD9A5F091" modified="2023-02-22" version="1">MEIIALMKSYFGGLLCLAWSSDGKYIATGGEDDLLTVFSVLEKRVICRGQGHKSWISRVAFDSFVTAINDTGSSSSLDDVLNGITESSEELRNNIVYTTASVNKYGYDDSMIYQNTNGIQHVTPIVNIVEPTASASTSHPIEHSPFEHGTQFTPSQSQISIAEMKNNSISNNSMNLCGLNTSQNSIHGGYRIGTVGHDTQLLLWDINDDILSSPMTTTIINPKSGGNTTIINVGLSSGPDTVSSLLINLHNFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU82</accession>
    <name>A0A914YU82_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRAPPC10/Trs130 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU82"/>
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        <property type="protein sequence ID" value="PSU_v2.g3226.t1"/>
        <property type="gene ID" value="PSU_v2.g3226"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3226.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17848" checksum="B761AD0B3961E377" modified="2023-02-22" version="1">MEDCPLLTTRKKSAFQISWNGSQECMQKYEKLIYESLKNGDGLIWRRHEKPIETKFEIKFVQFSEDQISLLDEVSFSESIAFVHLFFVCVSSPDEYRTQIRHRISEWFGMLNKAANSQWLIIFDSTKAKEKKNRGSVLEKIKSDFSKHQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUA7</accession>
    <name>A0A914YUA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUA7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3728.t1">
        <property type="protein sequence ID" value="PSU_v2.g3728.t1"/>
        <property type="gene ID" value="PSU_v2.g3728"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="10">
        <location>
            <begin position="408"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="648"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="963"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3728.t1"/>
        </source>
    </evidence>
    <sequence length="991" mass="111807" checksum="DD626B1ECE12F22D" modified="2023-02-22" version="1">MEHRVSEQMLMKTLETLYNSINGDLENCEARILALIMSVATIIKIVYGMRPNFSPWEKLLEKCPTFLTSSKSSVFKMKPPMISKRVVQIKGHSFVLNPVNLIVHCYQCREAVWGVNAQAYFCQNCDVIVHKQCATHLSDHCYPATQQKNKSSTTKNVKKPFTSSSSNLFGGSVSTTTQNRHESPSTSSTIDNLRTVGASQPMLSGGNNLGHLDRSTPDLRSIHPPPIPSSSVPPVPQQLPWTNNPSPNPPSSSVVVENAKSTSSDSGIGTEVSDRPVLRSQSVRAKTEIIRQSSRGKSAPTAWNAAEQLGPPPDEAYEEPINFRRNENDFDDRSLAVLKRIELASVSGSSSLSQTSVTEEERRRMIEKLDETVLAEGDSDLEIETEVPPLESIVSWEIIRHLKPKEKKRQEVVNELFHTERTHVRNLKIISRIFYKPLLLNAQIGSGEVIKLIFANLDEILEIHVEMRKKMKEALDRWRRDPSLNGLYGDIGELMEEIFSGPNGEKMIKATSVFCQHQQHALDRLRQCYGRPKDDAFASFLSEAESNPLCRKLQLKDMIPMEMQRLVKYPMLLETIAKYTKDPSPEQTQLLNSVTSAKKILQAVNGAKRNAENYRRLDELQRRLDTSSFDRNDQFEAFFQNFDFTKHKLIYEGPLTWRISRTKMVDLHVVLLETLMVFLTKGDGSKLQLKVHEAGLTPLLKLQQMIIKDKANDKRAFSILNRKDFRIFEFVAATATERKTWHRLIEIQVQEIGPQNEDITPEIPFDSNSSSLTPRPHSAFDDKKIERVHVVTHPRLVNANEITIQQPTVFEHAQPILTPTERLRRDDKLIVDALVDKQKILASFLGNEKDVNELEKMADSLSTLSVGDLKQKTSKELAMSAIVQGNRLLDIINKGMSAKKENGEKKASLPESDSSLPSVPCYQLTTISAHLMNHLMALLQVIQDQQSEMSGIKQQLYHYKDLAENGPGDRTVSEETLTEPPSQPPPLPPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVE4</accession>
    <name>A0A914YVE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3634.t1">
        <property type="protein sequence ID" value="PSU_v2.g3634.t1"/>
        <property type="gene ID" value="PSU_v2.g3634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3634.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16272" checksum="31F52C6E4C3DDE11" modified="2023-02-22" version="1">MKYILKNSTPEVWEKLIQTCKYFFSKNPVFPVGALSSRCTDGKWDGDCGIVNTNQPIVKLWLYKSLDGDFPATLTSLIPKLSKCSVKHLLIRGQNLNWEEYQFLTVSGLVTLFKFIGSTVKYSDGKIVTFDKLLENLKNVKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVK8</accession>
    <name>A0A914YVK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4167.t2">
        <property type="protein sequence ID" value="PSU_v2.g4167.t2"/>
        <property type="gene ID" value="PSU_v2.g4167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4167.t2"/>
        </source>
    </evidence>
    <sequence length="454" mass="51709" checksum="3E7FD5763955E37D" modified="2023-02-22" version="1">MAFRRSLPKTVEYLEKKMGAIVLNGYNIVGDGTPQAYIPILTGKIETELPLTRKRYKNANFVDIYPFIWKNFSDNGYVTMYGEDCANIGTFTYRLKGFKDQPTDHYARTFFLLSEKHFPTYQCFGSETQFTAWIRYCKEFMEKYPKETPKFSVMHHSALSHDDISLVKVVDDDLKAHFEELFEGGYLDNSVVFVGADHGHRFSVLRETQQGQMEERLPFMSVFLPESFKSKPEGQKVYQNLKANADRLTSPFDIHETFLDILSLSDDLDTVQSAANRGLSLFRPIPETRTCDQAGIEAHWCTCLQWQKANASVATELATAVIQTINSYTEDERKLCAPLRLQTVVDSKELVPDEKVMKYGGIKDKDGFVPKFSGNATVTYATYMITFTTLPGNAKYEATVQYDSKAQEVTVDMLTISHVNKYGDAPHCIIDKNYFLATYCVCYDKIGVSYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWF9</accession>
    <name>A0A914YWF9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWF9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4304.t1">
        <property type="protein sequence ID" value="PSU_v2.g4304.t1"/>
        <property type="gene ID" value="PSU_v2.g4304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="378"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4304.t1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51741" checksum="A4D9C2CDBD038476" modified="2023-02-22" version="1">MDESVTNFMAITGCTNDDDARRFLLSYDNDMNRAVDRYFNQKNRNFVNRAPSSSSSSMERNGGVEVIEAMDTNDAANEPGPSRRRQPIRRAVAVRNNHPAPSAPEVILDDDEEDIRRPIAPISGQLVNESFQQTWRAGVSRPTNGIFQATTDFRALARQQEQRMYANRVNGGPPNGLDRKPKTLQTLFQPPAELLFIGPWEAARHQATFQSRWLLVNLQNNSEFSCACLNRDIWNKEMVQELIKKNFIFWQVADDSPDLMEFLERYPDFAAYDQSFAQNLIKPGPSVEDIVIEEAAINGTKKQGSKRKLVDDETPSSSKRSRISQSNSQPNSQASAVDVDMGEIDELCNNGTKLTTVDREEWKNFIGPEEVGYQKIQIVFRLPNNEREKIEIPDTTELRALFCFLDGRGLNSRDHVLVLTYPRREYFYNRHSSQSLRQLGFNRQELIHVDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWH3</accession>
    <name>A0A914YWH3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YWH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4002.t1">
        <property type="protein sequence ID" value="PSU_v2.g4002.t1"/>
        <property type="gene ID" value="PSU_v2.g4002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21775">
        <property type="entry name" value="MobB_NDR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05599">
        <property type="entry name" value="STKc_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000057">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="87"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="384"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4002.t1"/>
        </source>
    </evidence>
    <sequence length="490" mass="56317" checksum="6F996D6284A772DA" modified="2023-02-22" version="1">MTASGSANNGEISQYIRDKANRTRLAIESYYAQTMLQCADRDNRAARLEKQIAGCSDSEKEEKRKTHASKETDFLRMRRTKLSVADFQSLKVIGRGAFGEVRLVQKVDTGNIYAMKILRKADMIEKEQTAHVRAERDILSEADCEWVVTMYFSFQDHINLYLVMEFLPGGDMMTLLIKRDTLTEEETMFYIAEAALAIQAIHNIGFIHRDIKPDNLLLDAKGHIKLSDFGLCTGLKKIHRTELYRNWPSQLPSDFVSKPFESKRKAETWKKNRRAFAYSTVGTPDYIAPEVFLIEKLGYTKTCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVVNWQQTLVFPPEMPISVDAKATIRRFCCDHDKRMGHSNGLEEIKQCPFFRRVDWDRIRELPAPIRIEVRGIADTSNFDDFSDADLSFPEVKEPPSGATNFAPTDRGEFLDYTFKRFQCLTQIMRYGGTNPTAQQAFMPSQQQQNANPKSVQQATPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWV2</accession>
    <name>A0A914YWV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWV2"/>
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        <property type="protein sequence ID" value="PSU_v2.g4131.t1"/>
        <property type="gene ID" value="PSU_v2.g4131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
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    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_6"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4131.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41839" checksum="89C575DDF8614FA0" modified="2023-02-22" version="1">MKINSTNLNSIRNADAVLTLTIKCSQKSEQVANPEARLFSRLRNLERLAIDRCKMEKIPPELFYGMLKLYNLIVKNADLKDIPANAFQYQSNLMSLDLSGNKLQSEPHALFSLKKLLQLDLSKNSINFVSNILQSSTTIKVLSLSNNELETLDFRRLPKSLTDLNLSNNKISTIYAYPESVMNLSRLDLSRNNLGFIAAKGAMNELPNSLNILDLSDNKIREIQENTFQKMTKLSMLDLRNNSINEITETALEVKIRYRYQLYMGGNPLKCACDNYWILHPKSKSSPIIADISNVTCYHVLDDSRKMTLLDAELMSGFLCKYDSNCLDGCECCQQRHEKKCNCYHACPAGCGCWGSAGAHATKVYVKYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX23</accession>
    <name>A0A914YX23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX23"/>
    <dbReference type="WBParaSite" id="PSU_v2.g263.t1">
        <property type="protein sequence ID" value="PSU_v2.g263.t1"/>
        <property type="gene ID" value="PSU_v2.g263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g263.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29156" checksum="28B807FDD205D2B1" modified="2023-02-22" version="1">MSKSRVHFDFDEYKSANFGRYDSGISLGNPLLSLSPSSLKSNISTTSDEIIDKQICTIISSCDVLSDNLKKLKERPKTRERGCQTDESGFDPIQMEECRNLMHKIDEIKHGLEHYKEKCEEQAAIIAQQNRALRGQEEIVQELTNMFNQKLDQLRNDFSRKAKTFVGTNISQKTTEVDQIRFENEISYLQAQNVQLRKELKMPSSPSSCSSFDSAFVEASMKSKEKDQKWQNRILNVCQNFKRTKSYRRRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXA8</accession>
    <name>A0A914YXA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXA8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2724.t1">
        <property type="protein sequence ID" value="PSU_v2.g2724.t1"/>
        <property type="gene ID" value="PSU_v2.g2724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2724.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10657" checksum="822CD706C0FB5550" modified="2023-02-22" version="1">MGFEKVLDDRGYDSGAYYVKDGKKWIFDIVALKQKQGATSDDELKILGYDVDTYNLVKNESNELAELYQDIAVEDGEPMYLEGGVYLYPDGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYE2</accession>
    <name>A0A914YYE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYE2"/>
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        <property type="protein sequence ID" value="PSU_v2.g4657.t1"/>
        <property type="gene ID" value="PSU_v2.g4657"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4657.t1"/>
        </source>
    </evidence>
    <sequence length="579" mass="66626" checksum="B5902CE09B944B14" modified="2023-02-22" version="1">MASTQNEIITVDDDNADDARLDEVVNNAVQIPLTMYSLNKVINRQWIDDATVDSLIYKDVIEGHDDRLMVSAVVWNQSRIESWGHDRRTPNRLPTMPRYSQTFTKAVISVNNDNSHWSLAILDKNTKLCTYYCTIRSRIGPNLQKLKLICRLLCDGEECEVVEAPANSFLLQTDGYNCGPMICMLAYRILNNESLSFGTAEANAWRQEVYNYYRPFVANSTTVEQDSYLKIIDEDAKKFQSDATTNVKKGMKRKTEISDKSVIARKHAKIAESVKNDDENMILLSDEKVKLENEVKEDFISFCNRKKKENAKIRLHSISRLTEINRIVKEGFSSSNDFELESETIKTVQTVEDDSKEISIDFEKKIEKELTETFEQFCKRKKISKKTSKSKNLYLSAVQTVEQKMVLNIKQKEAKRISRANLSETQKAVENETTRERMKEHYETLGDAEKANKRNRAKLNARERRSALSQTEKLVESNKVKQAMRNHRNPQNLIAAGGKEIDDNLEAHYLGPMDQICSNENCKAKHFKAEKVQGKTTFYSCCQHGKTVLPKQKPYPEALKKLFDLRTNLLPNKYSFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYF4</accession>
    <name>A0A914YYF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYF4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5127.t1">
        <property type="protein sequence ID" value="PSU_v2.g5127.t1"/>
        <property type="gene ID" value="PSU_v2.g5127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5127.t1"/>
        </source>
    </evidence>
    <sequence length="557" mass="63339" checksum="DD9A4C1D6D63999C" modified="2023-02-22" version="1">MADSYGKQWHHVQKHKKVGRFNCEICKFGVGSIQSYNDHMMLHGIIAGTNSVGPLEHTVSTSIVALPSTTLKQTSVESATTTDISSLGTDRRTTPDATSITSTSSEKDKSEERSTTNSLPGIAIAQDFELDMDWSGASPIPPPILSQRETRNNTESPAAQISGGPTTRGKYNKSPSKKTPLKQQQPQQQMPQLNGPYKNNIQIELPPFPAAIRPRRKRHLSDSSLQPSSSRDEEDDEKLHECKHCPFTCLDSKMLKFHTRMHDGERPQKCAMCTFSCFNIDALYSHMNVHAPQLPETMLNILKKKVAQRRRNGSLMERETISPNATNIFLCEQCSFKTAYQDRFLQHRMEHVQLLQQRLMTQMKRAANDDRDGRKSKIINRKKVERKWNYCTQCSFRCDTIVALMNHQEYHGSRNNLFKCRYCDYSANSHDVVTYHENTHHMDLPATNQSLNFNAINGIIDTDEVSEKRQKYKCTRCLYICHELSDYISHFEKKHIGEPEFEEIIQKLKMGLLPTLPLRSTNIISQQTCHATIAAQQQQHQLDSTISAAVALSEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYF6</accession>
    <name>A0A914YYF6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone H3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYF6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4671.t1">
        <property type="protein sequence ID" value="PSU_v2.g4671.t1"/>
        <property type="gene ID" value="PSU_v2.g4671"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000047">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="4">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4671.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11256" checksum="EA8A1D17C8529DD0" modified="2023-02-22" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQVSIFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZB3</accession>
    <name>A0A914YZB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAN domain protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5436.t1">
        <property type="protein sequence ID" value="PSU_v2.g5436.t1"/>
        <property type="gene ID" value="PSU_v2.g5436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF18">
        <property type="entry name" value="PAN DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="106"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="198"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="427"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5436.t1"/>
        </source>
    </evidence>
    <sequence length="618" mass="69516" checksum="DDE8C8CAD5A7E469" modified="2023-02-22" version="1">MLGSYGEIIQGCDDLNRTSYLRSEGMRIQELPRSTIRAVSLNQCAKHCSSKNNAVDCHSFEYNAASQICSLQSVQGQPFGPSIVANTNEPGISFFQQICIASEELCAAPYAFERFPQHVLVDQALETFSADGLSECLSLCLEAKRKLKLDCRSLMFYYETGECILNRETKKDLPKKFTNDTKFQLVDYFENNCYDVTCFGSSDIHWIRAEDFNIGIEKDVIMNGLTIDECKQACIENMVGAEMFPCKAFVYSTAKQECHLTAESGLTRKMSTSITTDDDTTSNRLNAELSAINAGQYYEKYCIEGPTKCKETSFEVIPDRMINNECVLNKKSQYSDPEIFVPAINVDYFDNICEYLPNSLPTTIGEAPRNVFSLDTESVQTDDKSIEEALYTFKEADDKNQSETRLKPVFQPLREPIEKVKGTLATECRLDGIIITAHFEEPTSGALFIKDHSSTCRKVFNNIVESQLEIPFPSSVDSNPDCPGIELAPNLWSFIVVIQKNNIGIPSLMTESDRIFNVTCDYSNTAVSASKLDSNQQSEVFVTSKTNEEFIGKIKMAILRDGKPVTTVSLGEELELKWNIENFKNDEKKQKLHCSDKLSTAAYQIAYRYNNVLDVINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZJ8</accession>
    <name>A0A914YZJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell morphogenesis protein N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5367.t1">
        <property type="protein sequence ID" value="PSU_v2.g5367.t1"/>
        <property type="gene ID" value="PSU_v2.g5367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5367.t1"/>
        </source>
    </evidence>
    <sequence length="1099" mass="124036" checksum="537E748B81B6D753" modified="2023-02-22" version="1">MAARRVGNDLSRRKSDPTSSKLGNNEAVVAAELPWGSLKVVGNMSIDFHSLPAKFTVQNLLLEIFSMFEKKIQYACIEEPLDKFLNKSLKRCDDTYLDNLLRTLGNVSEVCLPSILEALIKWYEEQISLRKRSSTRAAYGVNLHNCLIVAETFAEVIGVLSQTHAKLVQKTFFTLLNEYRKETPLTQSVVTNIISLLMALKFFRIKTSQVSEIEQGVSFLDELASYYLEIDLKQKDLKHAIVGLLVEILLPVAAQIKTEANIPALIAFVDKLYVPTLELINKKQHKMAAYPLLTCLLCISQSKFFLNNWVQFLNTTLSNLKNRDPKISRVALESLYRLLWVYIIRNNCEGNTQTRNRLECICNSIFPKGNRSVVPRDAPLNIFVKIIHFIAQQKLDIAFKDIIFDLLGCTRVTRSNTITIYPERMNIGIRALMVIADGLQQKEGPPGMPRTIVPVASGTIQRMRKTYLTRPLTADVARSIGLELYYLPCRKAFDAILRTLDTDVGKCLMLTSSRTKGKEPDDLIGSDMKPKLDLFRTCIAAIPRLLPEPMPHHDLIDLLTRMTVHMDEELRQTAYLTLQNLITECADWREDIIHTYINFLTNHIQDTFPVLLESAVRFLLQLLCFWKSAIQQEKKKENLQPTLNGIGTIISSIGRGTTTISNSAGVMIPPNSVTNASSHQSVQSEGGNAIGQPHLSPLMNNASAIALHNVEGLALALLCQTRVQGKKMAISLLREVKSLFSLMELHDKPVLTVLDEATPYVLNKYIEHVPLAERQSWNQDFASACDKICTIDTDDNLVNSDKGNEYMHWDTWACALSGYCEYKFLPEQCPTAVNFAWPTLFVRLNACNQFVDPNNPQNENRASLLRSSRSKATASTLCGEALDQGSYLSLWQKYLVMSCALTQPPSQHTSVLARSFSPNGNLDSIDSVRSMTSSFRGHRTSAQVNCVHLFQKISSMLRWEQTRDMRDNVVLGIGSTNPRCFDLLLEELLTKGILREAQERKNESNVRRRKRRDLLRLQVVRVIEIAMFRGLLSASNLVDSQTGQLSHILLDLFSAIRVNVESDSDRDISTITSLRLHFAKTITLMVNSIPRKLYHSFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2P2</accession>
    <name>A0A914Z2P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2P2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6157.t1">
        <property type="protein sequence ID" value="PSU_v2.g6157.t1"/>
        <property type="gene ID" value="PSU_v2.g6157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6157.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13955" checksum="05BCB8E9FEAF907F" modified="2023-02-22" version="1">MVLLVSALYAGCWAPQNLLMNIWITYDPSITSHPYILYIWWTSHTLAMFHSIVNPFIYYSQNRRIHEGVNYILRFLPCVKFTGLHLLEDKKGGTRAVRIVNMVAYLPIAGKETVHSTVSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3G8</accession>
    <name>A0A914Z3G8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z3G8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6443.t1">
        <property type="protein sequence ID" value="PSU_v2.g6443.t1"/>
        <property type="gene ID" value="PSU_v2.g6443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6443.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35649" checksum="9014AD313C40A418" modified="2023-02-22" version="1">MKEDDSIKKWVESRPDTSCIDLRASLQGGRTGPSRLSAKSVVGKEIIKYFDICSLYPFICSFFDLPIHHPRIVAGSQPYRTPEDVPFGLIKCKVLAPNQKIPTLGVKRHSMLIFANCNKCIELYGKPDKKKPKKNVGRISCTCTDEEREMVVTVTSEELKFAMMTGTVVKEVYHSLEYDKTSNKIFLPFIQSFLKIKTESSHPPADFNTYEGKRRFVDTYKSLYGITIDPENCAFNPGKRFISKIFLNSIWGRFSFQANQAEKDIITPQEFVALTKDETVFDLAAFEFEDNVLMANYKRDVNFIVAAAFYASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3Q0</accession>
    <name>A0A914Z3Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3Q0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6984.t1">
        <property type="protein sequence ID" value="PSU_v2.g6984.t1"/>
        <property type="gene ID" value="PSU_v2.g6984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6984.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="34855" checksum="AAB00FB77ADCD077" modified="2023-02-22" version="1">MIMDFPRDWELMKIVKKHRLVQILPQIPPPIRAWEMIQENTFKGFQGLSALIVDKWKESLKANLEQVFEEPEILNYDLYKINAKDYFTQKSKYHPEMPKLNSNMDSRVKELYLKQLRDRRLRQSEQEKERNWLQMFGEREYLRVVRNLIIRERTKVSVLRMMRDSDACNPIVYDSFRPRIETPSMKPETKEQVLEKILYLSKNLFNKHRMENDNLQMLQKDELEKALQNWDLIPPTKKIENKAVPRVKVMKVDFKYLTEEIKDSDEKMVESKRVEASREENSSRSGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3W6</accession>
    <name>A0A914Z3W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3W6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7393.t1">
        <property type="protein sequence ID" value="PSU_v2.g7393.t1"/>
        <property type="gene ID" value="PSU_v2.g7393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7393.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27631" checksum="78FC72CBF1BDF91D" modified="2023-02-22" version="1">MTKTRSQNDEITDLATTSSGGTLETTNTKASTPTTSATTSAATSSTATTAKTATTDRSTSSSESRKKPEYEIGTIIDGKWKVLSELGRGGCGIVYCVERCDDSNLEHPKAALKAEYVLKHYTETLAAEANILRKLQWSRHVCQLFACGRISNEINIVCMSLAGPSLSYLRRHSPQQRMTFSTGLRIAFHCLNAIEDLHCIGFLHRDIKASNFAIGYYASETRIIRILDFGFARSYVSTCIFGGYIFLVVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z411</accession>
    <name>A0A914Z411_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z411"/>
    <dbReference type="WBParaSite" id="PSU_v2.g663.t1">
        <property type="protein sequence ID" value="PSU_v2.g663.t1"/>
        <property type="gene ID" value="PSU_v2.g663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036972700" evidence="1">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g663.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14862" checksum="6CA76952D2D8F34F" modified="2023-02-22" version="1">MNYVKFVLIFGLFCFSLTQAYPLSPGSYTDLRFYRILGSRPFPRHSQWLPSKRSLIFPSFFNQGQQQQKRDIDTMADFDPSDLAIKFGKRALSARDRFWLGKRRSSVGQDYDSMVFPENAAELAVRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4B8</accession>
    <name>A0A914Z4B8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4B8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6842.t1">
        <property type="protein sequence ID" value="PSU_v2.g6842.t1"/>
        <property type="gene ID" value="PSU_v2.g6842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019265">
        <property type="entry name" value="RTRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15924">
        <property type="entry name" value="CLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10036">
        <property type="entry name" value="RLL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6842.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25434" checksum="373698A2DAAC65A7" modified="2023-02-22" version="1">MSHMKLWALRYAKPQLDFNDETDVCDLITFLDHKYFHHGFAHDAGNVMELDEHLKQYITDVGLEYSNEIRSSLIDVLLNAAVTRNLREKLVGHAGDACQAANQLRLAKILESMNQEELAAFDELVRSKAAELKITSYPSTMRMAMAILSCNTEPSPENDSAFKLSEVPSGIKSTGDSKVDDALKILRMINVYRYRDLQTQVNEHLASLQEITADPKADTKIGRVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4J4</accession>
    <name>A0A914Z4J4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HIT-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4J4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6816.t1">
        <property type="protein sequence ID" value="PSU_v2.g6816.t1"/>
        <property type="gene ID" value="PSU_v2.g6816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6816.t1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56198" checksum="FCF8E0C5E49879DC" modified="2023-02-22" version="1">MANVGTQSPPTIGPPAEKKIKSEIDCQLCGLVKSKYTCPKCSFRTCSLPCVKLHKEANNCDGQRKPFEVVKKFSQFDDNISVKDQEYLNTLKSAVSGGIRSTNNIVKHAKPEEDLSRKRPYPEESLPLNEEEISLQSDPNETINSHTTNIQHEASFAESTPSEEVEENEFLKKHGSGPSDPNVLSHIERYLITSAVRRRIFITINSPAEADGSRHEQHSDTIIWTAGLKFLREVPIKKDEEETNDSLIDDVGEEFVQINGYTTSKHNDIVEYDCVARSIPENLTVNTLIRQFVKPKEFGTVVSKKELDEEKLQPFWDAGLDGVLVFMKVPVGEKERYYMVDKSKSILDNLRNRYIIGHPEFIVILPNQFQQWQTLSEMEAQELHDERRVQNKIRHQNDGGNRGHRGNFNRRNGGRGNNFGGGGGFRGGRGGNGNRGRGFRGGHRGASRGQNRDLASRDLSEIFEPFSSPSNARISRPNYSSNNNDAALNGWASAVNRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5H7</accession>
    <name>A0A914Z5H7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5H7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7932.t1">
        <property type="protein sequence ID" value="PSU_v2.g7932.t1"/>
        <property type="gene ID" value="PSU_v2.g7932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7932.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14825" checksum="BE654535FBD5F91B" modified="2023-02-22" version="1">MLLAPMEATKVRIQTSPTAPPTLRGCVPMIYKTEGLSGFYKGLPPLWMRQIPYTMMKFACFERTVELLYKHIVPKPRADCTKSEQLVVTFIAGYIAGIFCAVVSHPADTVVSKLNQDAGASAGQILKKLGPMGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5M2</accession>
    <name>A0A914Z5M2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5M2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7199.t1">
        <property type="protein sequence ID" value="PSU_v2.g7199.t1"/>
        <property type="gene ID" value="PSU_v2.g7199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7199.t1"/>
        </source>
    </evidence>
    <sequence length="742" mass="84563" checksum="A74FA2F88B35000F" modified="2023-02-22" version="1">MRRRNTQNCAELVNSHIYEPRFHLCEPISVVEYVDEQATIKKRVAQSDGVAVEIVKSYKVTHNSVEATFDEQENNCFESDALKILEKDGNAMSQNDVYPAPERLQNNLSNIRGASKISQSDSGCSVSVSSSEPSISCRITRSRTKKRESETHVESVTKLIDGNFKYVHEDNGKRNKIFVFEGSREFGRIYNYSFGMWYCNGCYLTNGQRVCGSFKKGVFHHPSLHLCEPITVKQFEKDQQRIQKKHNLASPKVKPTNESLMEIHSNETSEASNVATSSKSDYSEQLSTSIMSVDVPVRIVDILNFEYAFNEVAQIRKRFTVYEINRSFVRQYKVEENEKWYCINCKTGYVKKNDDTAEIFGAHQCEPIPASEYRKRDKLQREKYNALKKAENVILTGSPSSTSNNIESLRQLNFYEWEYKTNDRSVIIVYENYSKHLIREYKYDKDSQQYVCIGCFNATPSTPCIGKRNDDDFSIMVPTSENHICSPHLKEEDNSKNNGCKKRGRIDDKEDESSAIKKARNSATVGCEESEYDSAANRRDILTSPEKPSPLISNAQNASVSPCASSNLVEFHYPSGKALVDFCMKLKLPYSCDAVMFWSRSAITHVAHDSVPGECFSVVEETASAFRCFSVMFTGTEENFLELKTTLLPYLCSNIRFIGDKYGLNLTQTDTPLFTEHVLGNEASEVHFEALSAFLECRIGIFENNQWKRYGDWSEINAQNHNICTFLLQKVGSKYSIVLSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5W7</accession>
    <name>A0A914Z5W7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z5W7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7305.t1">
        <property type="protein sequence ID" value="PSU_v2.g7305.t1"/>
        <property type="gene ID" value="PSU_v2.g7305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7305.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27609" checksum="7B86702006FA459D" modified="2023-02-22" version="1">MFLVMLHQCFPQLATKTPRGENEQQDANECWAELVRCVNNELDVDINGKKVNFRKFIEGVHQIHFKNTEAEDEETHSVETFTELSCYLSQEVKYLQLGINKTKENITKRSEKLGKDAVFEKTTLVSRLPGYLCIQMVRFFYKEKEKINAKILKDVKFPKILDVFELCTPELKERLAPKRTAFKEYEDKAVEILRQSKLDEGKKGKPESIKYAPFSFDDDPGSNNSGFYELQVRNCYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z697</accession>
    <name>A0A914Z697_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z697"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8208.t1">
        <property type="protein sequence ID" value="PSU_v2.g8208.t1"/>
        <property type="gene ID" value="PSU_v2.g8208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8208.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="42145" checksum="CD1CC5B3F6D01B10" modified="2023-02-22" version="1">MSRASFLSRDSPLKNGTKIINNINGIRNGHFIPNGSSKPPLNNTMPKILTDGNNRKRSFEPARQQQQQQPTTSSDKRPRISALGKKDIHGSVNYIVSEPNHGFPAQDGEEFAGQFRCTSLNCNKVLSNNVSFMYHLWAHIAFFQRREFSTDYDQMTDEKFTRMCSVCLTVFETAFEKTRHYLEVHRGVFATYRLCHLCETVDHDGKHVTEIKHRQNELPYECRKCKFRSSSRMSLIDHFSKVHIGTTMLMCPFCPFSTQISASERMKPVVLAKNYVQHVTEHGNVIAKKCSCCSYKFIDEERFEKHTKCHQIEQHRWPIQFKAFKTLKEEALKTKPRHEQLTLLKCVECSTQFPKAEDHFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6T8</accession>
    <name>A0A914Z6T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6T8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5967.t1">
        <property type="protein sequence ID" value="PSU_v2.g5967.t1"/>
        <property type="gene ID" value="PSU_v2.g5967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5967.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48732" checksum="80A663136FE0DD5B" modified="2023-02-22" version="1">MIPLRPDQVHTLIFMDFETTGMIPGNIENSRPTPGDKSRSIAHMVTRNCNVHDNPSEMPQITEMAFVSVPRQLFASAVEDIHAEAIFDEDGPLLKKIPSNIYVSQIKPNLTFNQWKQYEETQRHCSAMHLSQMDLKYKNSFVVEWPAVHAFLKNQKPPAIIIAHNGANFDFRVLYSELVKNKLLEKYPLPDGMYFMDSYLAFLDIEKQHLDNLAVTTSLINWEKVDGVMGLAKRTSIIEEEVEVNSNVAEAATNAAGTIKNDNNVVDIVEDSMDIFQTDDISMEPQTSATSLLRPPMDGMRTPPQKRKVPVGSQSVDSGLKRKTSETNWEFNKIGAREYFFKGNFKLESLYKQISKSSYDAHHALDDCHALMQVSLAYGEDFINYMENRKEKIPLFYAKRFPTPVAPRRITPTPAEATITVNENFENST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7T6</accession>
    <name>A0A914Z7T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protection of telomeres protein 1 ssDNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7T6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8393.t1">
        <property type="protein sequence ID" value="PSU_v2.g8393.t1"/>
        <property type="gene ID" value="PSU_v2.g8393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="9">
        <location>
            <begin position="304"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8393.t1"/>
        </source>
    </evidence>
    <sequence length="684" mass="77014" checksum="91C7BE8C5D7C460B" modified="2023-02-22" version="1">MAKDKYVYTKLNEIEGSNLKEFNIYGIIKDVFHKQSYDRKGEDQDEYRLKVHDGTTGDEDICVTAFVPLDQMPSNVFAEGKIVRFHRLQKNFLKDNGGFYLCGRIGPISSVLLFDVPTPGSRFKFNPCYRSSVNYSQTDKDDEMLKDIISKADAILSDQQHHPTTSLAPPIQNTPALRRSPRLSPQKVNATKTQPPSATKTPAQKQQQFHSQSVTTSSRRSARLKEITSPVISVTIEESSEEEVNEPAAAEEENLQQKPQQSQISPVSQPIQSQQRQQRSNKKSPKTNEREFFTEISYLICGNSNYYNILCQIVSCYRNSRGDIFLRVWDGTRNPRSTHFLNFNKSDLIYGDSIKEKRIAADKKLYEITCYSEHGVDAANLRTGDYIALINMHFFVPKSCVKPTMVMHDGDGTIRTEKGVVSAGRKVIKVTSAEHRTAFTHIDGLIRMHEPNLPILEEEENDTTVDPQERNVAPEVSDETWNEFLGISPKKNVAPTVVSQRITTQASTITLSSDGSTQNIRLSQFSPDRDFEVISTELAGSSSLNDHFYPRPSFSQLSAATSSSFVQRPAASNATVPQVQGTTKGIFARRPAPIPFDTTTQTSQLQPTLPKRFRLTQSPLKSQDSCSTQTLLDKFKINNEYDEDSSSQSQHDELRRLEAITDTQLENMWAEVENAELQPSPSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z830</accession>
    <name>A0A914Z830_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z830"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6407.t1">
        <property type="protein sequence ID" value="PSU_v2.g6407.t1"/>
        <property type="gene ID" value="PSU_v2.g6407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022559">
        <property type="entry name" value="SUP-1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10853">
        <property type="entry name" value="DUF2650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6407.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15205" checksum="BFE72FE1CA2B6314" modified="2023-02-22" version="1">MMSEKPVEHQNSRVVIIARPSDTESARRRESPAYISEQVIYPETDTFCLLPSRMRFLCILLTILLIISLAAAIGNSIQSAGFKSTSFCKADWQDFGPDVLCPKETMVHYFICCEEEFGSTQKLVCCAQFKIWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8K3</accession>
    <name>A0A914Z8K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-mRNA 3' end processing protein WDR33</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8K3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9003.t1">
        <property type="protein sequence ID" value="PSU_v2.g9003.t1"/>
        <property type="gene ID" value="PSU_v2.g9003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9003.t1"/>
        </source>
    </evidence>
    <sequence length="383" mass="41767" checksum="E79FD4CFB0B895F4" modified="2023-02-22" version="1">MCYSNLVKRIRLSFFILMPIFLALAWHPIHETLFVSGGGDGSIGYWLAEPFSELGLYDGAHDQAIWALDWHPLGHILSTGSNDNNTKFWGRNRPGDTLEELNGMMASAKDTHHQPINNFQYYNYQVKFHEEDLHRDYPIVPGLGVNEHVLNDMKEISILPESIPGSTTLPDDYGPRNTFTSNIGAKRTLIKQPPPKKAQRQFERTWTTTKPGSDIPEELLPASFISPPLPSNGPSTSLLGAPRTSLLPRPGGSLLGRPTIPPAILEQQSIPLQIIPPSSGGESWRTGIVSPPIIIKEPPQWFQRSGGYSDGSTFPPPPSSSSASHGIGFPPPPSAAGGGGGGGVYGYDGPSIEHPYSNDGRKRRADDSEDPSLNGNGKIHRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8W8</accession>
    <name>A0A914Z8W8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8W8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8776.t1">
        <property type="protein sequence ID" value="PSU_v2.g8776.t1"/>
        <property type="gene ID" value="PSU_v2.g8776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8776.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8965" checksum="B412EDC0AFEE2A3E" modified="2023-02-22" version="1">MKEFNGEEIAKHNSEDSLWVIINGKVYDLTKFYLNHPGGVGVLMDAAGKDATKEFEKADHSLDSKDIMRDYMIGFLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9Z7</accession>
    <name>A0A914Z9Z7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mon2/Sec7/BIG1-like HDS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9Z7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8610.t1">
        <property type="protein sequence ID" value="PSU_v2.g8610.t1"/>
        <property type="gene ID" value="PSU_v2.g8610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HDS" evidence="1">
        <location>
            <begin position="911"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8610.t1"/>
        </source>
    </evidence>
    <sequence length="1142" mass="129000" checksum="E9CC66B13FC1C88F" modified="2023-02-22" version="1">MDAIISKLSTHSDATKGVSNLLELCTLAKGLRERDDMPAFEKRKRCLSLFECAVGSGKPKLAHMGIEGLQLLLRDSAFNSDSDSSKDEQRTAVQTLSHLSSLPTWDKGIQCQAVTVIVQLISNTEVKVLLSDLYAAIQLCANTYKTSEDQSVKLAVRAALTQLLNSFCINRYSNVGPESQDEIVVFMDMTALIKELLTRIDSGQQASADELQLGLDALYSTVSVQPPHFYKHQPLFNVFTTELIPSLLCLLQFSGEKQEKAKSFLERARSTTKSQRATIFTTSDMARSFYQLIEHILKLMAPLQQTSRSLTVELFRSAMVVPPPEKRYEPLRLLKRFTTTPSFLSSLLSLMALDDSVWPVIAECVEESAKQTVSTEVSVDAIRTLQIMFDAFDSISTTCDETNFTKEFFERIKANNDFEAQKNQKPEESEIHETAVVKKEISDSAQDFVNRLRNAAIEWLKVESSTELDQKFQKFASDFISHSSSETSESNGSETQLLNCDAAYICIYAALSFSLRFSETSPKKREFLSTFICDGCIVYASDGWISSVYRILQNDPLFASDNDKVSLSRKSVLESIIEDFDGHRNKLLIYQSIRSEIPAADDAAPPVIIEEREIKSKEMEQIDIWMHRLLSNCWRTIEIILGRFPLKADKKLSSEKFCVEGAEATLEAMRSFSRILRHFSMKREILWLYEKFGEEICNLEELREFINSNGAEKKSWPMSRVDALGLDLLFENALISGSLSFNCWKHVVRAIEFCSELERHQFCLTKSANTSYEQTNEIHGLRDLLGKPSQKDLSLKTIGKVLDELMLKIHAFFENAARQLNLPSFVALLDYIVAANENNLKYSDNGRIPESCSLLQRISKLVVGAAARPQIHLMKIWSTVSGHLAESSGARFPEEVSRLAVVSLGDCVQALLRDEIPGFCFNQGLFGVFQNMLCSDSCGAETQEHIVTILCSFIQERPNQIGSGWKMLFGAIKAIRIGNIKEKKKSKTSLSMVHFAVLEVLKKYFEIDDPKIFVPTALEFIFCVNHYLQSTIENGGGDDQSVDANISQNEEREGAIAETILQFVEVCQKLFIEYFDSNDLPAFQPLINRLKLREKSIDFVEDNYDQRFFDLPPLSSILREEDQLGVFPSDLNESIKSMKKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA12</accession>
    <name>A0A914ZA12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8626.t1">
        <property type="protein sequence ID" value="PSU_v2.g8626.t1"/>
        <property type="gene ID" value="PSU_v2.g8626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8626.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18168" checksum="710BD5ED72C85797" modified="2023-02-22" version="1">MGYKQLTKFIYRTPYLVDFASSQVDEAMNRFIMDNHVRIDKREEDMILSGEDVVHNGVNKALISDNVLIIGNPLNGTRLRFDDILGFIDEQILAISPLDPEIREELEEAIRKKFRNDLAIIDLPLGGAANDEGNCGIYTAVMSTNKLVLFFSSVFLHKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA19</accession>
    <name>A0A914ZA19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3456 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZA19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8769.t1">
        <property type="protein sequence ID" value="PSU_v2.g8769.t1"/>
        <property type="gene ID" value="PSU_v2.g8769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382:SF8">
        <property type="entry name" value="CANOPY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382">
        <property type="entry name" value="CTG4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="4">
        <location>
            <begin position="69"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8769.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16637" checksum="8175C3FD73C0748A" modified="2023-02-22" version="1">MQLLPLPQSFAPLLYLFFFSTTILMKIIYAKEIEKYSQIDPNNIQMPTKCEGCLILSREIETVLLKLNTKIGKEDAEIWLIEKLETVCEEMLHLKIHKEKPGIDRFSPDSSKTMKTLKNLRKKGVKVSFIHFFKNINIKFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB97</accession>
    <name>A0A914ZB97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9581.t1">
        <property type="protein sequence ID" value="PSU_v2.g9581.t1"/>
        <property type="gene ID" value="PSU_v2.g9581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9581.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16381" checksum="224BCFE010463FC0" modified="2023-02-22" version="1">MEEIIKSEAFSIFVNLHKNENLQIRRNIAGTLTLVTHYGNVKHILMLYQMKLFPAFCNLLIKAEKIADKKLLNTILAGIFGVSLKAQEYSCSIFEEFEQCGSIDIFIRLKSHDDENIRILSQGIFVFLMIIMLTDNTCSKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBH7</accession>
    <name>A0A914ZBH7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="5">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZBH7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9664.t1">
        <property type="protein sequence ID" value="PSU_v2.g9664.t1"/>
        <property type="gene ID" value="PSU_v2.g9664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000007">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000031">
        <property type="entry name" value="Phosphoglucomutase-like 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="134"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="250"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9664.t1"/>
        </source>
    </evidence>
    <sequence length="505" mass="55117" checksum="56778F52CF7168B4" modified="2023-02-22" version="1">MDVSYLCPQAVSVIIKICAANGVKKLIIGRDGIFSTPAVSNLIRKRKTDGGIILTASHNPGGPKNDFGIKFNCNNGGPAPDGMTNKIYDLTTNIKEYRLCPDLNVDFGVIGSDSFQIEGVGTFDVEVIDSVEDYVELMSEIFDFNKIRDLITGKATGEKLKIVADSMAGVTGPYISTLLVDKLGASPDSLLRTVPKPDFGGGHPDPNLTYASHLVDILKKGEHDIGAAFDGDGDRNMILGKNGFFVTPSDSLAVIAANLECIPYFQKTGIRGFARSMPTACAVDRVAKKLGHKCYEVPTGWKYFGNLMDAGRLSLCGEESFGTGSDHIREKDGIWALLAWLQILAEKKKSVEQIIKEHWQQFGRNVFTRYDYEDVDAGGANLMMKYLEPQLPNFVGKKLSANGVEFTVKAADNFEYTDSVDKSITKNQGLRLLFDDDSRIIFRLSGTGSAGATVRLYIEGVIDNNVGLQKLFAPADDLLRPLVLIALETSKLQQFTGRDKPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC57</accession>
    <name>A0A914ZC57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9502.t1">
        <property type="protein sequence ID" value="PSU_v2.g9502.t1"/>
        <property type="gene ID" value="PSU_v2.g9502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9502.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23570" checksum="4089837C8F66C7D3" modified="2023-02-22" version="1">MQAIEANDEQQVITGVFELPAPNRDTLAYLILHLQKVAKFSSSNKMPIENLARVLAPTIIGYSKRFTVKMSEEFTISCHQTMILHRLLNLPSQFWSQFIENNISHFAMATSTEEEEEDEIVPTRKSTTRSKSDADILAAAARPTTPIMMIPRSFSSRQSRRIITNNNSKTGLRDTHSEEKPRPKRPSPIMRSFSYASSFVRSFRSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHR1</accession>
    <name>A0A914ZHR1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17341.t1">
        <property type="protein sequence ID" value="PSU_v2.g17341.t1"/>
        <property type="gene ID" value="PSU_v2.g17341"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g9841.t1">
        <property type="protein sequence ID" value="PSU_v2.g9841.t1"/>
        <property type="gene ID" value="PSU_v2.g9841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324227" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17341.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9841.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="6547" checksum="9DEF0AA871E403B4" modified="2023-02-22" version="1">MKFFYILVVFFAFIGSTAAFGFGGGGGGGCGCAPPPPACGCAPPPPPPPPPPPPSCGCAPPPAPCGCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XPX6</accession>
    <name>A0A914XPX6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914XPX6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10069.t1">
        <property type="protein sequence ID" value="PSU_v2.g10069.t1"/>
        <property type="gene ID" value="PSU_v2.g10069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10069.t1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37876" checksum="1A199F100C25A01A" modified="2023-02-22" version="1">MHVLVTGGAGFIGSHTVLELLNSGHTLTVIDNFANSIPDSDGNAVSLKRVETISGKKIPFKKVDVLNVPQLEEVFKTEKFDAVIHLAALKAVGESSAKPLEYYINNLCGSLNLISLCKKYNVKNFVFSSSATVYGSPKSLPIREDAQTGPGITNPYGQTKHMIEQILIDIAKAEPEWNIVILRYFNPVGAHPSGLIGEDPKGVPNNLMPFVSQVAIGKLPVVKIFGNKFDTPDGTGVRDYIHIVDLARGHVSALDRISREGNIGLEVYNLGTGKGYSVLEMVAALEKASGRKIPTELSVPRPGDIASCYCDPALAAEKLQWKAEYGLEEMCRDLWNWQEKNPKGFAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQM8</accession>
    <name>A0A914XQM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XQM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1031.t1">
        <property type="protein sequence ID" value="PSU_v2.g1031.t1"/>
        <property type="gene ID" value="PSU_v2.g1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1031.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10136" checksum="53019ADDEA139D3D" modified="2023-02-22" version="1">MLALLATQTSAAELPGKFEGVTINAKLIGGQQYEALYSRIAEWEKATGAKVNILSKKNHFELDKEIKSDIASGSINWRNRRLRAIGDQGFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS96</accession>
    <name>A0A914XS96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NHR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XS96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10857.t1">
        <property type="protein sequence ID" value="PSU_v2.g10857.t1"/>
        <property type="gene ID" value="PSU_v2.g10857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000005">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase NEURL1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF6">
        <property type="entry name" value="PROTEIN NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NHR" evidence="6">
        <location>
            <begin position="38"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="6">
        <location>
            <begin position="267"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10857.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36073" checksum="191690C953D0C2B9" modified="2023-02-22" version="1">MPDNMCFFKGSGGASNRTFSAFDETVINRGTIASPRPLIKFHTVHGSNITLSDNRLLARRRQNVFCKGLVFSDRPIEIDEIVCIRLTEVCNSWSGVLRFGVTNVDPASFRDIELPKFACPDLTAKTGYWAKALADRYSIQGSVLHFHLSTLGTLYIGCNGYSKGSYLHEIDVSKPLWVMMDIYGKSVAVEFLNEINDATRTTAANIEEGRLTNLSNNRNRVPNPATSLTTSSTSSIPAPTPSAPSFSALSHPVSSPSVTNPALETLPYRFHTLTGVNVTRVSDFEIVRKDNQYDRAYCFLSRPIVIDEVVSIKLNKIFTEVWHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTL5</accession>
    <name>A0A914XTL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTL5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11300.t1">
        <property type="protein sequence ID" value="PSU_v2.g11300.t1"/>
        <property type="gene ID" value="PSU_v2.g11300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11300.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9593" checksum="F7F6B4DEE92AD963" modified="2023-02-22" version="1">MSKNFFGSNWSSQDNGDENHDKNEKDKEDEKTSSKYGHWGSSDDEKESKYDSYGYDKSPGYQSSPDRSPPRKIDDNEYYFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTS3</accession>
    <name>A0A914XTS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10663.t1">
        <property type="protein sequence ID" value="PSU_v2.g10663.t1"/>
        <property type="gene ID" value="PSU_v2.g10663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037679086" evidence="1">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10663.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15256" checksum="D7B34BA0C20CE3AF" modified="2023-02-22" version="1">MSKQNYIRVREICLLFYCIIFVSSASVKHSLPETPKVLKDESLYYDRSIPDYETVLTPSDFEMSTHMSEVMLFSNEQTDIWDSDAMYNLDKFEGDIANDLNASTIPLFVQGGPTNSNGTNQHNAIRNLVTGKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU66</accession>
    <name>A0A914XU66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10510.t1">
        <property type="protein sequence ID" value="PSU_v2.g10510.t1"/>
        <property type="gene ID" value="PSU_v2.g10510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10510.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11894" checksum="8D7D225041827F94" modified="2023-02-22" version="1">MTSPYSTSNIAMNQGNNVTTTTDPIKQSKVYPNSLFRLLAPRKLITLSTCPDCADQIFKSQKTGGIIHDPASDTVTLTIKLCRSCVAENQSSSFAQLKLVKKSDQNVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUW9</accession>
    <name>A0A914XUW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab5</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUW9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11039.t1">
        <property type="protein sequence ID" value="PSU_v2.g11039.t1"/>
        <property type="gene ID" value="PSU_v2.g11039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003486">
        <property type="entry name" value="Major sperm protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11039.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11849" checksum="125C6C66BDBEEB54" modified="2023-02-22" version="1">MANRPTPRAGNGGGPSKTCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV56</accession>
    <name>A0A914XV56_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XV56"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11818.t1">
        <property type="protein sequence ID" value="PSU_v2.g11818.t1"/>
        <property type="gene ID" value="PSU_v2.g11818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF101">
        <property type="entry name" value="SERINE PROTEASE F56F10.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11818.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29504" checksum="09FADC9E89838D1F" modified="2023-02-22" version="1">MDMKLHQNRHRNKFLQISKGAAGAEDCAEESYFTQILDHFDNKSTVTWNQRYQINDKYFDTAKNSSFVGPAIVLHIGGEQETIDERVICYEIFPMVKMAKQHNALLIQLEHRFFGKSFPIIKNGSMADMSVPTLRQFLTVQQALEDLANFIRNFKYKNVEWKNPKWILFGGSYSGSLCAWSRAKYPDLTVGGICSSAPIWPKMDFFEYSQVMEFAITNYSAIKYPNCAKSVTNGFTQLRQMSYTDDGRNTLNNLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWN1</accession>
    <name>A0A914XWN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MoaB/Mog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10171.t1">
        <property type="protein sequence ID" value="PSU_v2.g10171.t1"/>
        <property type="gene ID" value="PSU_v2.g10171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050101">
        <property type="entry name" value="CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE AMIDOHYDROLASE PNCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939:SF0">
        <property type="entry name" value="NMN AMIDOHYDROLASE-LIKE PROTEIN YFAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10171.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15825" checksum="937BAA890E54559F" modified="2023-02-22" version="1">MSSNSFEATVKRKTAGIIVIGDEILKGSTADTNSNFLCRRLHNRGVCVKKISVVADEVSEIAREIAEFSKAYDIVLSTGGIGPTHDDKSYEGIAAAFNDTLLLNSELKAVFDDVLAKYKQRPDAEESISKFCSVSFKVFFVMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXE0</accession>
    <name>A0A914XXE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXE0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10418.t1">
        <property type="protein sequence ID" value="PSU_v2.g10418.t1"/>
        <property type="gene ID" value="PSU_v2.g10418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10418.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22007" checksum="46A759930D04E173" modified="2023-02-22" version="1">MTASSDTVSVIGGLYITIGVIGFLCNGATVFMIIMKRVFRLSAYTIMANVALADAIMMIVAGIACGMGILWSDSNCNIIDANGISMENISSKNMTSTTYAFLSLSYKTGTNCSFLSFCLAFFEIAAWTAGVVSYAYLGLNRCVAICFYGTKAKTFNRVTVALIASVSTWIIGIAAACVGTFPAPLVGNRTEMWSVSFLSTEGKRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXS1</accession>
    <name>A0A914XXS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12744.t1">
        <property type="protein sequence ID" value="PSU_v2.g12744.t1"/>
        <property type="gene ID" value="PSU_v2.g12744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12744.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9856" checksum="69AD570544BDE55C" modified="2023-02-22" version="1">MITASSGTGFEISPIGVRETFVNGLSLEYTFFRPEFCFIGDVAPRKSRGERFDNCRRKAGMKGLRDGVTEADRGCPNFGSKSGIVDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXX3</accession>
    <name>A0A914XXX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH La-type RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12050.t1">
        <property type="protein sequence ID" value="PSU_v2.g12050.t1"/>
        <property type="gene ID" value="PSU_v2.g12050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12050.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17873" checksum="36420112F528EB6A" modified="2023-02-22" version="1">MNAKLIDQVEHYLGNENLSHDKFFRDEMKKDHGWIPPLTFFLDAMLLKELPEIRQLSRQHWKIAILLMSQMMDKKFVVILKKPLPENMPQYWHELKCRTVFIVSFQTGFKTIYPKWGRGDTAAYVEQENPDFCMTTFMNIPYKGTQQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYH3</accession>
    <name>A0A914XYH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PhnB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11585.t1">
        <property type="protein sequence ID" value="PSU_v2.g11585.t1"/>
        <property type="gene ID" value="PSU_v2.g11585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007537">
        <property type="entry name" value="PRK10148.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990:SF1">
        <property type="entry name" value="PROTEIN YJDN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990">
        <property type="entry name" value="PROTEIN YJDN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhnB-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11585.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13828" checksum="7FE7506DEA4575F5" modified="2023-02-22" version="1">MPLSPYLSFCRFGEMPKSAQDSAENCPSGMQFPDTAIAHANVRIAGSDIMMSDAMPSGKASYSGFTLVLDSQQVEEGKRWFDNLAANGKIEMAWQETFWAHGFGKVTDKFGVPWMINVVKQQPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZW0</accession>
    <name>A0A914XZW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WW domain-containing oxidoreductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZW0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g135.t1">
        <property type="protein sequence ID" value="PSU_v2.g135.t1"/>
        <property type="gene ID" value="PSU_v2.g135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g135.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35685" checksum="10A5DDAC28BAEA6C" modified="2023-02-22" version="1">MAEVTLTTKEIPKATTVTTTTTTTTNFPAPPAQGLDGDVSAADLQKDEPVYHRKYGSRTDAMTIVEGMDLTGKTILITGTTSGIGIETARTLALKGAHVIMANRNIIQSEQLRDKIYAEYPDPDKRNNIDLVHMDLSSLQSVQAAAKEFISKGWPLHVLILNAGIISGPTKTTIDGYESTFGVNHLGHFYLTYLLLEKLRENAPSRVVIVSSNSHNHTRIAPQLPVDQKLNKLIPEPATTENGYSLYAYSKLCNVLFAQKLHREEHKNGINVYVLHPGSMINTNISRGYPVFSKIVSIITKPFVKTVQQGAATTVYCAVSPDCTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0N9</accession>
    <name>A0A914Y0N9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y0N9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13021.t1">
        <property type="protein sequence ID" value="PSU_v2.g13021.t1"/>
        <property type="gene ID" value="PSU_v2.g13021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040053">
        <property type="entry name" value="JOSD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291">
        <property type="entry name" value="JOSEPHIN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291:SF0">
        <property type="entry name" value="JOSEPHIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="7">
        <location>
            <begin position="14"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13021.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="22017" checksum="5ABBB21F046EF622" modified="2023-02-22" version="1">MGENGSEMEKKEPEFIFYHEQQELQMCLKHALNNLLQRPAYTKELLNDYCLHLDDRNWFNPHRSMLGLGNYDVNVLMLALSSVEEDLTLVWFDSRLKYKNVNNEKVFGYIFNKPNTGLLSLITRGRHWFTVLPIDDGRHYNLDSKLARPERIMDFPEFFNDHLAKGGEILIATKFEHDGVIKKPTEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y100</accession>
    <name>A0A914Y100_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y100"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12462.t1">
        <property type="protein sequence ID" value="PSU_v2.g12462.t1"/>
        <property type="gene ID" value="PSU_v2.g12462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="172"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12462.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33440" checksum="6990C122D6E16C14" modified="2023-02-22" version="1">MRDSIARNDVVIEKANLTIMSTQKEVEKTLKISDETRKKIQKATTDKGFIETQYKALVKKQNDKYMAAGEYCPKCSATKIVLKEFGDDVKKLKSDVSRLEKECQAISTQKSAIESEHINLQKAYRNVVYERDIYKKDDKMLREHLAKAKKAITETTNSPNRNLKLLEALNSPARLEHSPIQTKETPPPLIKAEKSPTPPDKTLVEKSNEPPPKKRTNGTSLSREEGEVTPEDETTKSPQIKRESPPLKTNESRKRPLSPMSTKAEKPKQMDYVYVINDRQKPPDKMPKPEPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1I1</accession>
    <name>A0A914Y1I1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1I1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12649.t1">
        <property type="protein sequence ID" value="PSU_v2.g12649.t1"/>
        <property type="gene ID" value="PSU_v2.g12649"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12649.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17312" checksum="C05560A2B32C0DB5" modified="2023-02-22" version="1">MHFYRKDKHYVSKDDLQEVINKNDVNVKWTGTKFTMKDLKLQRINTKTLQSLGEIYYKRVVTSNSVRTKKLPILPDPSRNDNVIVDKPPVYYEMLESKFESFSASLNAQIAQITQKLATLEANNEATKTRLSTLIECSHATSTCTQLPIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1K4</accession>
    <name>A0A914Y1K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1K4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13338.t1">
        <property type="protein sequence ID" value="PSU_v2.g13338.t1"/>
        <property type="gene ID" value="PSU_v2.g13338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13338.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10804" checksum="1934380D1A1327A5" modified="2023-02-22" version="1">MMPKFKDLMEKKARFVLALDYQRSKSHHNLKLLEREFQVLTMQVRIETATRPGGLGQTLENLVLKANAKTMGVNFMPQIEKCGYVFKNLNFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1U1</accession>
    <name>A0A914Y1U1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cns1/TTC4 wheel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1U1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11784.t1">
        <property type="protein sequence ID" value="PSU_v2.g11784.t1"/>
        <property type="gene ID" value="PSU_v2.g11784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="3">
        <location>
            <begin position="128"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11784.t1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29176" checksum="916E591F256E9EEC" modified="2023-02-22" version="1">MIRCCELLSEFEKTGKRTLQFATNFIEKLESPPEGREKEFAEAKEKLKVFKEIAAKLVAKEKEEAPKRQAALLKDLQKKEKLLQMFKKRGLEFRPEIDFVNFREFEWTMLDVNFPHRPTTRVDFEAGSDILEWPLMLQYPETAQTDLLTECPETYTIETLIQPVLEQPAEWDRNHAFKLPNIRVFIALDIFDDEQIKEISLDDTLGNVISNKDYLIVQGLPVIQIYTKNYIASKLAPVEGKIGIYKFKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2J1</accession>
    <name>A0A914Y2J1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2J1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12008.t1">
        <property type="protein sequence ID" value="PSU_v2.g12008.t1"/>
        <property type="gene ID" value="PSU_v2.g12008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="12">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="171"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="398"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12008.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="54525" checksum="3D8D0190E9F46547" modified="2023-02-22" version="1">MTNNTRNVRDKAYIEEQKEIIRNFLEIKSSELDPKCLTSPTTNHFQALFEFIYSHLDPDYHANSCTIKDEFPTIMKSLKYPLQIKVSTMQSVSSGTSWPYLLDALGYLVTFVTKVETMNIMSLVDDEGSDSSRRSLAYEYFTKCFNKQKAGNVPEDGFAAEYKNFREAVMQNENIDEAEEISREKHALQEELAELKKNVYKKIVTYNEDANGCYTGRLDKNKKLQDVINEKETVLKTIQNDIITKRQTIDNQPISAQKALEATNKLKTVRDRLKSANSEKNDAADGSTALQGTLFKLFESLNQRVAAVGGNICDIAAGFYSHEEHSQHGFSELGINRPMDLDSVKDRFKHFSELYDKLLGKIAQDLEQKRCDTKRNKDAVAECERAIERINISTKKFVQDGEAKINELQRRNNELQFETKKLEIRAGVFDEKQLLADEKLNKVRKELEKLQRLIDQHSELFDSVDKFQDDGTTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2N1</accession>
    <name>A0A914Y2N1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2N1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14436.t1">
        <property type="protein sequence ID" value="PSU_v2.g14436.t1"/>
        <property type="gene ID" value="PSU_v2.g14436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14436.t1"/>
        </source>
    </evidence>
    <sequence length="608" mass="68753" checksum="818E40863E1869AB" modified="2023-02-22" version="1">MLVYESIPTNEHLQQISSGTIRSISAHSPSPPCVPSPNVNTMDMRFGSMSLHSRRGTKNRLPYYWERIVTKNNLKFSHERFQYTQGYFKFIRDMTRFAALQCKEKMADTKLAKQAIHVFACFLFSTAIRCPNDFRIAQMREWQYTIEILFENSDVAKWFITHFLIKGNIIHCAVLQPNSTLEMRKFMEHLITIPTCICMAISDSNGEEFPSADIEADSAADEIIKKILQVSKSHTMDFWNNGFHVLHILIVIASQSVQSARRLVSQNALYAMLVLLNHRDETRIRNFCRDNPHIFKFLALLFTSCTSMKKPAKDSPIIANPFSRPSKKAFFVPENAQMWFGTGSNVTRFFHLCIDSVLEIQQLLDLCCYLCWQSLPISFRLISILPLGANDASVKTTMILFKKLLEIDDIVQSERIKVACLGNEMSRIKGALVECATAAQISQINRILPVLIEFLPMTKEIPKIKESLFGNPIFSNSLEKINVCLEKFIDPSGVGGGAAATSKASWNIGIRDYLPILSDIHESLKELIAENQAYLIQNSISSSSFGITNSVSATASMASECGEISIEEAVIPEEIDETLEPTTIGMFNTTYRQRGGYEREVPRESDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3L7</accession>
    <name>A0A914Y3L7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3L7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13824.t1">
        <property type="protein sequence ID" value="PSU_v2.g13824.t1"/>
        <property type="gene ID" value="PSU_v2.g13824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13824.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23117" checksum="3A134C77389F54CF" modified="2023-02-22" version="1">MENLYDRYSPISSGFFNESYGSYQNIPSDPAAYIPQGHFYSSPDNSWNNPSSNHPQSVSPSEGFSLLNLVDNCYSQAVAEKEQGIKPDYTECPWLKNPEGKRGRPAEYTKEERKWAKWRNNWIYNEKQEMTKSIQRADQLLTHKTNQELKNEYFQLCLEAIVLSENLCPHNQSTVHAAMENPKIEKQICICEGNQSHGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3M8</accession>
    <name>A0A914Y3M8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3M8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1338.t1">
        <property type="protein sequence ID" value="PSU_v2.g1338.t1"/>
        <property type="gene ID" value="PSU_v2.g1338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1338.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35398" checksum="8BA89B94B3FFC793" modified="2023-02-22" version="1">MPNSSDNYYADSYYNIPPQRNNVPGRGRPLNRNRQYGQESENERRKRSFVIIGLPELRGGSENEMREQDHLAAMDIVRYLGINDVVPKTHVKRARNGPVLIITLESIESRDLIIKRSHFLRRIEQTRHLKLDRAYTVQDMVQRYGRLPNEDDLDDPNSEYNSVYRRGINRRPPPSSNGNYSHPPNNYGSSGNRNNQSRTNSHSDDYHIPSNNDYGYDQRGSNNNPRGRGYSQNNDDTYSNNIPPNQRAIRGRPISRNYDDRYGYSNNDNYPSNQNDSDTFRRNNNNPRGNPRGNPRGNPRGGGNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4N1</accession>
    <name>A0A914Y4N1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4N1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14193.t1">
        <property type="protein sequence ID" value="PSU_v2.g14193.t1"/>
        <property type="gene ID" value="PSU_v2.g14193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14193.t1"/>
        </source>
    </evidence>
    <sequence length="460" mass="53429" checksum="745BC55C2B8D0646" modified="2023-02-22" version="1">MVRNATTVYLPAKYATYDVPWLQQQHSIFLYKSPTLTYNWSWFKELKIQGLDTTLSTVIELLDQHNCYFVAYGRGVKNIIIGAVKDRSLLEISGETTCNAFKIYNICKEYFDIDNCGEKPFTSKDEITMGNSNIMKMYDEAIIGPITLYPWGSTYETDRLQWSFSVNRGGIFDDGVGFTRFIDVTGHSQFDICHKSIIIPVQQKYWNDWCANSLLKTLEFYNLIADGFDASQSLHQFLTASIVKYFDTAIFQNYYCVNVLGGEFTPSQTLSYQRRTHPFCRYLTPDARRNRLIGIINTTLRRNLGDFWHRNVEKALADLHQFKVNGKPQRTIKIDFVNEIRQRQYQSSAQNNNYRVPYYPSLTPSPTMTSYYHPNRNYNNDYPQHTSNNVGYNRQTHEATTVTYNPPESTVISHEVKHYALGEYPKVLSEHVPDLLNPPTIDPPKNFSNPFQWYLTVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y659</accession>
    <name>A0A914Y659_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y659"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14252.t1">
        <property type="protein sequence ID" value="PSU_v2.g14252.t1"/>
        <property type="gene ID" value="PSU_v2.g14252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14252.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17823" checksum="D413517844201727" modified="2023-02-22" version="1">MSTGIKIQSIKEDSGYHALIHGLSECIKVVTVGCDTEDIKPRLSFVTKDAKKFLKDFAKTFKPPYKSIVFNVFQSFHGTNFDSIAFCDQLKEEVQKLKIPYYFISSETFLPAAFLAASKYTSEIGDIIFVPTLLPNIICSWAYQREADGYISIRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7L6</accession>
    <name>A0A914Y7L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7L6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13603.t1">
        <property type="protein sequence ID" value="PSU_v2.g13603.t1"/>
        <property type="gene ID" value="PSU_v2.g13603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13603.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12900" checksum="EABCFBAFC1B8559B" modified="2023-02-22" version="1">MSPGWVRDGWLTGTHWSPQDFMFHGWKKSKLGGEWHWPFSNETNMGNFSSCKFADSEFANFKYLPKFIKSNSEINEILGNKVKAVAKDYENILKRIHPMCSKPCLTAIPSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7V5</accession>
    <name>A0A914Y7V5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16284.t1">
        <property type="protein sequence ID" value="PSU_v2.g16284.t1"/>
        <property type="gene ID" value="PSU_v2.g16284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16284.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11146" checksum="338F909DE881BC1E" modified="2023-02-22" version="1">MFQSPQSTTSTSSSNLKDKNLDSIEVSERQAACAKCKHYKALEDAIESIESPLFPFYNELKWILYGSLWIGISFLFITLIFRNQFCVALDRLEKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8V5</accession>
    <name>A0A914Y8V5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15701.t1">
        <property type="protein sequence ID" value="PSU_v2.g15701.t1"/>
        <property type="gene ID" value="PSU_v2.g15701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="67"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="266"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15701.t1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52141" checksum="FC26AE2C91EA430A" modified="2023-02-22" version="1">MREIVHMQAGQCGTVIFFTKSLKKQNKIDYILGNQIGAKFWEVISDEHGIEPTGAYNGDSDLQLERINVYYNEASGGKYVPRAVLVDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDNVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLTTPTYGDLNHLVSMTLSGVTTCLRFPGQLNADLRKLAVNLVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTSQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGVKMAATFIGNSTAIQELFKRISEQFTSMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADDDAEYDEEGHDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9A1</accession>
    <name>A0A914Y9A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9A1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16016.t1">
        <property type="protein sequence ID" value="PSU_v2.g16016.t1"/>
        <property type="gene ID" value="PSU_v2.g16016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16016.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13249" checksum="D975024854B388C4" modified="2023-02-22" version="1">MYIEKEGDKMDRVAVYDLCRKIDKIDKNTAEIEVALNAKRREGEDIETESNRIQNIKQEHVDSGACRLNSDHTAPSQIDEIMQENNLDKPEVVIVKEKLNGPNGNLIISRIPMDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA02</accession>
    <name>A0A914YA02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17044.t1">
        <property type="protein sequence ID" value="PSU_v2.g17044.t1"/>
        <property type="gene ID" value="PSU_v2.g17044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF122">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037087722" evidence="8">
        <location>
            <begin position="19"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17044.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24005" checksum="A8789AF8048357F8" modified="2023-02-22" version="1">MGFRFGTILCVTPFLVLAISVDDAYLMINSWQRIRKEKRELDSISATIHGKIPSPSEDDETLQSILAGVFIDTAPSITITTLTNVLAFGVGALTPTPEIQLFSIGNAVAIIVDYIYQWTVYGSFMAIYGRIELSANGKILKKENIEKDEIQIENKSRTKIVKGCNNKALTNPFISSLIMALLAVYFYISLYGILNTKAELQPTKLFLKTSDVLEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAX1</accession>
    <name>A0A914YAX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14639.t1">
        <property type="protein sequence ID" value="PSU_v2.g14639.t1"/>
        <property type="gene ID" value="PSU_v2.g14639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14639.t1"/>
        </source>
    </evidence>
    <sequence length="348" mass="41884" checksum="45CC2A100030016A" modified="2023-02-22" version="1">MSHLRLIRKRPHSKAVNGVFWRGKYKAAFFKQYDVKQDDNLYKDFRPNFMKLPEVVHRHVLEFLSVSDRIAMEQTCSYFHYISRATPWIIKKCEITEDNKIFHIKLDDICHRLEYPEGNRNEMIKSIHCFMRNVRVIDKFKYSKPHLNDTESYIIIESFLPYIYNIQEIELQSMKVSVNFLKGLLKKLPNCKAYSLKDVKFNKKTMIEEIWPSLKQMEKLTLHNISNFVYENSVFTLLQNRTEPKRPLKSISFLLKNKGIDPQQIFLFSRRLEEFDRTQMAKIRIMFPSEWKQRKREGANRDKLYNLLTDNYDEFVRDRVLVSILMIRDDEFHTASNGNLFYGKYPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBJ4</accession>
    <name>A0A914YBJ4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YBJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16642.t1">
        <property type="protein sequence ID" value="PSU_v2.g16642.t1"/>
        <property type="gene ID" value="PSU_v2.g16642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="15">
        <location>
            <begin position="53"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="248"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="356"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="356"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16642.t1"/>
        </source>
    </evidence>
    <sequence length="453" mass="48042" checksum="37AE1E416B99FD41" modified="2023-02-22" version="1">MRLQNSPSDKDTEEQVDKMEDDAFLRCVEQNLLSDLTLQGIEAIGKVYMHKPNTDDKKRVVMTSDGGFQMVAEWILETDQVKVNGSSSALLKVLSEPQVDPIRTYSNDICEVFEVLGIEAVRKAIEREMNHVISFDGSYVNYRHLALLCDVMTAKGHLMAITRHGINRQEVGALMRCSFEETVDILMEAAAHAEVDPVKGVSENIMLGQLARCGTGCFDLVLDSEKCKQGMEIQSNVGYAQPIYGGDALSSPSSSSMSPAQTPWSGATPGYGGDWSPMNGMTPGASFSPAQVGSDGGYSPSYSEGWSPRPDASPAHSIGGMSPGAMSPGYGGSRSPYSYSPMSPGGGIGYSPTSPSYSVKSASYSPTSPGYSPTSPSYSPTSPGYSPTSPSYSPTSPGYSPTSPSYSPTSPGYSPTTPNYSPTSPRYSPTSPSYSPTSPSYSPTSPAGSIIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBS2</accession>
    <name>A0A914YBS2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YBS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17650.t1">
        <property type="protein sequence ID" value="PSU_v2.g17650.t1"/>
        <property type="gene ID" value="PSU_v2.g17650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17650.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21571" checksum="FED2B419136813EF" modified="2023-02-22" version="1">MYEFCPIGMQFQGNAKTWVWVNSGALWDYVAYFMGLPLPPSYAAPQMADTGDSLTFVQRLKSIIGHTLTPLFVYKFTAGPQTEIFRKHFGSNFPHLTEIAKDAPLVFVNSNELYDLPRPTLHKIVNIGGLGMKQASAKPLPKEYSELIEKVESVVVFSFGSVANATLMPMEWKQAFMGAFSKFPNTQFFLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDZ7</accession>
    <name>A0A914YDZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17523.t1">
        <property type="protein sequence ID" value="PSU_v2.g17523.t1"/>
        <property type="gene ID" value="PSU_v2.g17523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17523.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15474" checksum="FB36A8130945DEC7" modified="2023-02-22" version="1">MSMLRTPENPKRQRNGFNPTFGINLDGSSLNDSSMLSSSSSPSFIIPEDEQTRRRQQLYGLKVLKKTNTTTRKNGQNSTIFTETNTTTMNFLLPQIPVFKQSRFPRLEESADEDDDEEEENEMEDSMLNHEDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YED6</accession>
    <name>A0A914YED6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YED6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17660.t1">
        <property type="protein sequence ID" value="PSU_v2.g17660.t1"/>
        <property type="gene ID" value="PSU_v2.g17660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000018">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="entry name" value="Formyl transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="2">
        <location>
            <begin position="212"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17660.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33749" checksum="B5D9510BA7E10486" modified="2023-02-22" version="1">MKLAIIGKSAFGADVYSRLLEAGHEIVVVCTEPDKNGRADLLALVAEKNGTPVIKVARWRKKNAEGKFEIVQDVFEQYKSFGAELNVLPFCTQYIPQELIDAPKHKTIIYHPSILPAHRGASAINWTLINGDEEAGLTVFWADEGVDTGPILLQRKCDVEENDTLNSIYKRALYPEGVNAMVEAVNLIAAGKAPRITQPEEGASYEAYITTKPELAEIDWKKSQREIHNFIRGNDAVPGAWTILNGEKFILLGSSLWKRDEPPLSARKVEAKGAVGDAVYVHDRGVLFPTSDGKFVCHLFLSFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEV1</accession>
    <name>A0A914YEV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17989.t1">
        <property type="protein sequence ID" value="PSU_v2.g17989.t1"/>
        <property type="gene ID" value="PSU_v2.g17989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17989.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17365" checksum="9671DF20D8198666" modified="2023-02-22" version="1">MDAWEPDPANSRFITKVNRRKTYLIVIAVVGIILFIGGLTTMIILLVKDNDSSPNTVDVTVAPNTTLAPLTTTPPSTQNETIIIAFNIGFQSVENETLQKVKTSVITLIDGLPWEAGNIKVKLVPYSDISDNDYAVDNLKTADDVKLYLNAFLKLLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF12</accession>
    <name>A0A914YF12_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Letm1 RBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17899.t1">
        <property type="protein sequence ID" value="PSU_v2.g17899.t1"/>
        <property type="gene ID" value="PSU_v2.g17899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="1">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17899.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14705" checksum="9217DFDFBF3A6CCA" modified="2023-02-22" version="1">MNQTSASHFQPLIEQLPAKQAKELHFPLNMKEIKDVNVMPLDELDFKQMYHLSLMKNDLASLDDMSTDELYTQMFIRCLNFNGLSDDEMRNVLRNWIKNSADISSNDSLYIYAPVLLQYKKKNANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF75</accession>
    <name>A0A914YF75_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YF75"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16028.t1">
        <property type="protein sequence ID" value="PSU_v2.g16028.t1"/>
        <property type="gene ID" value="PSU_v2.g16028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16028.t1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35163" checksum="66848FD731B3391D" modified="2023-02-22" version="1">MEEVLSMKSSGASTSVIVSTLVQGNTNFSERTNYSKEKYVSKKAKHHSDQVYILAPTIRMIAQTIYRRNSETASFLRPDMLSSMLYYASIIGGSKVLVYDESCGLISAAVLQRLDGKGELYLLYKNLTFNSHEALQAMNFNPIETMPFRPIRLSNLAKVIVKETPLPPHGMPTVDTTTASTAVSAAPPKESFNYSDENLFAEVDIKEQLIWIHERILDRSFLDSIIIVSNAVSPLELLQHTFKSLRSSGTVVVYTVIQEEICEIYTFLEENGAINIQIQEQSNREMQILRDRCHPMLQTHVASGYLITAIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGL8</accession>
    <name>A0A914YGL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGL8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17934.t1">
        <property type="protein sequence ID" value="PSU_v2.g17934.t1"/>
        <property type="gene ID" value="PSU_v2.g17934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17934.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23043" checksum="8A3D7DBEDCEC6C91" modified="2023-02-22" version="1">MNSTQDPHCSNDSIPDSTLPSDHPLYIDPTKKLTRFDLILMNNYKSIESYSSPYSTVSDTRSSTTYTSSKSLNDIDKTLNLNSDSNISEASTSIIMIPNITTTTCSTDDNEDDDNDEDEGASLSTSSDDENTFSSHHGYHHYQPPQQYSMERSFSDFGSLSTIPEVPTPITPASNVDNISFKNYCGGKEDSYEISFDNDRKVSTSSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH46</accession>
    <name>A0A914YH46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH46"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1663.t1">
        <property type="protein sequence ID" value="PSU_v2.g1663.t1"/>
        <property type="gene ID" value="PSU_v2.g1663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019176">
        <property type="entry name" value="Cytochrome_B561-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21780">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21780:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09786">
        <property type="entry name" value="CytochromB561_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1663.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="45075" checksum="6A49D31F5F0B57EC" modified="2023-02-22" version="1">MRKSVTPSSLAVYTDEQLGKLSKMETAHAYILFEPKYNKYPNYEYHQSVNVEEDEDQNFNSLNRSQLDLLDISEHYSTHPDEHPLEPVKRKTASSSGFKRGKSPAPVSETGTRLSSSYHLHTLPKNAPMTRSPKFLMAQKPTLTPITKVFTQWRVDGTSLITMTENIRKFLSRHIIHPLAKEINEINAFFLTNQRTRNISIGKTPIADIEKMFGQIQGNKVANLPYVLAFLRLHSNYVHFVKRILTWARSDFIFDYCPDTITLHSTSWPEIFPASKTILPTDSELIFRLFCFYMDTQCGLYPITYPYPCDLPFTHLHTLQEGKKPSDAQLSTSGYYVEFSDAQPVTFKFYASRYPAIVTPATPNALLTILMLLVYGHGREWYDVLSRTGRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHN5</accession>
    <name>A0A914YHN5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="4">2.5.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3-deoxy-D-arabino-heptulosonate 7-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">DAHP synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phospho-2-keto-3-deoxyheptonate aldolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YHN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18992.t1">
        <property type="protein sequence ID" value="PSU_v2.g18992.t1"/>
        <property type="gene ID" value="PSU_v2.g18992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="12">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18992.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17480" checksum="21EA45A71444A052" modified="2023-02-22" version="1">MDYARRLTVERKRFAPELEIVMRVYFEKPRTTVGWKGLINDPFMDGSFNINQGLRTARELLLAVNQLDLPAGCEFLDMITPQYIADLVSWGAIGARTTESQVHRELSSGLSCPVGFKNGTDGNIRIALNAIKAASQPSPFPVGHQGRSLRHCVHRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI80</accession>
    <name>A0A914YI80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YI80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1852.t1">
        <property type="protein sequence ID" value="PSU_v2.g1852.t1"/>
        <property type="gene ID" value="PSU_v2.g1852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1852.t1"/>
        </source>
    </evidence>
    <sequence length="575" mass="64560" checksum="A00D13393DC02E49" modified="2023-02-22" version="1">MLGSFAYKKIPPKENIIFRVVKTIKTALVNKFRKGAPQRVHWLDHSLDKHTCATNDKCNNTQTKPFYTSLCIESRFVEDVKSLIRVLIMMLPVPFFWSLYDQQGSRWVIQAIAMDGQITDNFALLPDQMATLNAILIMSFIPIFQFLIYPGVEKIGIRTHYLRRMVVGGILAAMAFVISGFVQIGVNQTLPDIPKRDVSFVSLINSYGSNCNVAFNIPGASQTILPRNTVIILNLIFCYKSVNLQSLIDNKVEKIQTLLRLKPNTYLIQITSTGDCQGNHGAVTLTAKFEGGKSYYVAATPQGVFYDSTKWDKPTEGQGESSLRMTLLSPCNTIMNLTVRSWGCNNSGDTSSYFGRIALCRYNPENVEHPCDPRDTSKYFYYAWKTENDDYKRIPVYDYNGGGNLKANGTAYSFIDMKPGIYKAYYVKYLLGDSDRTPAKEEIAVVEIQGSTFEITGMGGVYSLIISKNGQVSSNISPNNSNVLNIYTIVPRNHLSILWQVPQYIVITAAEILFSITGLEFCYSQAAPSMKAVLQAVWCFTVALGDLIIIIIAELDLFPNLVRLKIFFQKFISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIT8</accession>
    <name>A0A914YIT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19219.t1">
        <property type="protein sequence ID" value="PSU_v2.g19219.t1"/>
        <property type="gene ID" value="PSU_v2.g19219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19219.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8971" checksum="6B3E661224B163C8" modified="2023-02-22" version="1">MIKANANQINWKISDNFIQFKNFICFFSSVCGFALVFDFVKDCQHVYKVLDRKKLNYGNSQLTIIILNLTLIFDVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJI6</accession>
    <name>A0A914YJI6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YJI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17474.t1">
        <property type="protein sequence ID" value="PSU_v2.g17474.t1"/>
        <property type="gene ID" value="PSU_v2.g17474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07958">
        <property type="entry name" value="Anticodon_Ia_Leu_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.290:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.590:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="135"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17474.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32698" checksum="B506410FCC80CDEB" modified="2023-02-22" version="1">MRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGHTAKGDVAALNVDALTEDQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJZ6</accession>
    <name>A0A914YJZ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJZ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19853.t1">
        <property type="protein sequence ID" value="PSU_v2.g19853.t1"/>
        <property type="gene ID" value="PSU_v2.g19853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="entry name" value="YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050423">
        <property type="entry name" value="UPF0337_stress_rsp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026042">
        <property type="entry name" value="YjbJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34977">
        <property type="entry name" value="UPF0337 PROTEIN YJBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34977:SF1">
        <property type="entry name" value="UPF0337 PROTEIN YJBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039008">
        <property type="entry name" value="YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19853.t1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7867" checksum="93CB87C3F31AF5B4" modified="2023-02-22" version="1">MNKDTIEGKWKQLAGKARSVWGEITDDEWAKVKGDATQLAGLVQERYGRTREEAEREVKDFYDKYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL39</accession>
    <name>A0A914YL39_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914YL39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g196.t1">
        <property type="protein sequence ID" value="PSU_v2.g196.t1"/>
        <property type="gene ID" value="PSU_v2.g196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g196.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13223" checksum="2790D47131501D10" modified="2023-02-22" version="1">MPKKLIDYVNDRGGKVRFFNVNQPDGEWGCLLHAFQSAVALEKKNNASLLSLHRLASENNDPDLTNLLEEFYLREQVIEIQEMTRKANQLRRIGAGLGEHIFDRELLQEMQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL90</accession>
    <name>A0A914YL90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB-dependent receptor plug domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g21115.t1">
        <property type="protein sequence ID" value="PSU_v2.g21115.t1"/>
        <property type="gene ID" value="PSU_v2.g21115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042912">
        <property type="term" value="F:colicin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042931">
        <property type="term" value="F:enterobactin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044718">
        <property type="term" value="P:siderophore transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="entry name" value="TonB-dependent receptor, plug domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="TonB-dep_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069:SF51">
        <property type="entry name" value="FERRIENTEROBACTIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="TONB-DEPENDENT OUTER MEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52016">
        <property type="entry name" value="TONB_DEPENDENT_REC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037965830" evidence="1">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="TonB-dependent receptor plug" evidence="2">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21115.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17293" checksum="AE15ED23FB67E78E" modified="2023-02-22" version="1">MSRAVVLSPRPLALAVAALLAGSALTPQAETDATDIDTVHVTASQIARQALGTSTITAEDIAKRPPANDIAELLRTMPGVNLTGNSASGQYGNNRQIDLRGMGPENTLILVDGKRIGARDAVRMGRSGXRNTRGDTNWVPAEMIERIEVLRGPAAARYGSAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLB3</accession>
    <name>A0A914YLB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20338.t1">
        <property type="protein sequence ID" value="PSU_v2.g20338.t1"/>
        <property type="gene ID" value="PSU_v2.g20338"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g5694.t1">
        <property type="protein sequence ID" value="PSU_v2.g5694.t1"/>
        <property type="gene ID" value="PSU_v2.g5694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20338.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5694.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14777" checksum="87816DE5FD986144" modified="2023-02-22" version="1">MLFMFVVPCVVTAYFFAIFWSSMFEISFGKLEDVLISALMGSPRRPPAPEAAANEIPQSPKPGDPDMSMGQIPYDQTTTGAGAKVSPETNGTEGNLKLESLRKRNGGYNSEIPVFNTNEKVATIRLTKLEEQAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLG9</accession>
    <name>A0A914YLG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zonadhesin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLG9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21186.t1">
        <property type="protein sequence ID" value="PSU_v2.g21186.t1"/>
        <property type="gene ID" value="PSU_v2.g21186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21186.t1"/>
        </source>
    </evidence>
    <sequence length="770" mass="84938" checksum="D11FA957B78F5428" modified="2023-02-22" version="1">MPLFFQHNHCRHRHHGHIDLLNNRQFAQPTFNQAAFEKALPPTPTVVKNEYTPPTPPIRTDFNPYIPPSPRPREGFGPVQPAVTRPVNPQDQWPANTRKPAGGSYGMEEIPHRENNHIQIQPINPTPEVPNVQQHQWPTTTQQPLTSGPVVAQNKPENLVPIFAASSHLPQPVPTTTPTLTRLPMKQINTVEHVQPTAPIAPPRIIQPINKEVNNQYSNIRETVEITASPVAPTKPERIETIAPVAPSTTPQTNSVPDEYGRERETVESVSPVVEPKAPEHRVNEKINNEYSSGPESFKPIILPQPDGKPINHEYSSGPETIEKPSSSPAAPAVEKSESAPVTSAPTAPERNTEATVKSPQAPNVGGYKEAQQETTKFPTLKPEAPTTSDSPKDNVEAQKPETETETPEESLVVLNKASSEAAPTPPEEEIEKSAEKTKEVEKLQTVPETYEISDITASSTSAPPAVKEKINNNYEVKATSNVNEYRVFGEKSNSQNAIEPSKIPEEKTLGKPKIALENNVIRLQVIDGGSDRSVGRKPIALPEGFVNIPINKEMEKALLEETIIPHHSVFEGKEKTKSEGEEKVIETKSENEVRIEAVTNPSPIPPRAPPTMSTPPSRLVFAEKHERIEILNSSTNSPKPEFEAQTSTDSSITTTTATKKLIRIQPIHPTPTTTKPEFEEVEVETSLPTITTTLKPLSPSVHLEEKILTPIIEGDIEEHHPHGMLEEIVIPHVRQEEVSEIPTNEFVEPIKTEVVTESSSTTTAPERNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLN9</accession>
    <name>A0A914YLN9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLN9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19821.t1">
        <property type="protein sequence ID" value="PSU_v2.g19821.t1"/>
        <property type="gene ID" value="PSU_v2.g19821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19821.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7651" checksum="E4F5320F36919DA9" modified="2023-02-22" version="1">MLGLFSLLSALTPKSNPWMYRSLWFIANDILCSTNAPILLALNKPIRKKFLKLIGFKIASTQKSSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLR7</accession>
    <name>A0A914YLR7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLR7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20507.t1">
        <property type="protein sequence ID" value="PSU_v2.g20507.t1"/>
        <property type="gene ID" value="PSU_v2.g20507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20507.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38626" checksum="B200DBC3849344E6" modified="2023-02-22" version="1">MPTLPASRVNKSKPFQSTGVDYCGPFKVKGSNEKVWVILFTCFTTRLMHLEPVSSMTAEDFLLSFRRFVARKGVPQYVLSDNAKQFKTASTALDELWSKAISDSKAIDYCNEKHIIWDFITERAPWKGGLYERLVGLVKNALKQSIGRKFVNFNEFWTFLTEIESTLNSRPLTYVNAEDAFVIRPIDFVSPNLQINLPTNLSDDQSNDPAYFPSSACGGERLVERYYKTVEYLDKFWNLWSQNYLNFLRERNINQHKNRRGAIERQPIVNEEVLVYEPDQPRGLWKVAKIMKVVTSTDGEVRSAEIQYNDGFVTRRAVNHLYFLEEPTPSVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLY6</accession>
    <name>A0A914YLY6_9BILA</name>
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        <submittedName>
            <fullName evidence="3">CheW-like domain-containing protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19928.t1">
        <property type="protein sequence ID" value="PSU_v2.g19928.t1"/>
        <property type="gene ID" value="PSU_v2.g19928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="CheW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19928.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9843" checksum="972D36CFA20A49FA" modified="2023-02-22" version="1">MFLPCNVWRGTPPRRGPDYSEIFMSNDFTSHSEAAEAGGKEYLVFTLGDQEYGIDILKVQEIRGYDSQTVTRIANVPNFIKGLPICVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMH7</accession>
    <name>A0A914YMH7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMH7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2059.t1">
        <property type="protein sequence ID" value="PSU_v2.g2059.t1"/>
        <property type="gene ID" value="PSU_v2.g2059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2059.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="38077" checksum="B1B31626FB847B93" modified="2023-02-22" version="1">MPVEKIFALNLSKQCNTVHLSPTINLCLYSTIYGDKNAKHTEWRNQNNVIAQLKNYTSKNRFELAEEALSFPHRYIEAIYGKYLFYSVSPITDDVKYKYDTNKRIYDNINEIRHDINKWIKCIKGIQDKEVIIQNIELKLGKYSNYKNKNLWKFYFKFLKKNNLKEILEAYRKYTRLFISDKEAIEKYRQEIIKFTHLKESTTKYWIDTIKYEMTFGNLEHAYGILECGMEVVVGTQYNFLAKDEKHLNGILLICRILMMQAETNPTPAPAPATISNHQIEVKHLLSQTPTVYFECANRQSLPFRQSYIQYILNNANAIIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMI5</accession>
    <name>A0A914YMI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMI5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18533.t1">
        <property type="protein sequence ID" value="PSU_v2.g18533.t1"/>
        <property type="gene ID" value="PSU_v2.g18533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18533.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8180" checksum="59A32A43513C6317" modified="2023-02-22" version="1">MNLPFSGRSQTLHLEILDIDEPPTFLNSPKPFLAVVPYDRPIGYQVYQFVGRDEKGDGDNRIEYRLINSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMN5</accession>
    <name>A0A914YMN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20198.t1">
        <property type="protein sequence ID" value="PSU_v2.g20198.t1"/>
        <property type="gene ID" value="PSU_v2.g20198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20198.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16289" checksum="5C1ED2786E558BF8" modified="2023-02-22" version="1">MPKKVTKDKVWKDLCIHANPDMSASSAAGYQLRRHYVKYLLKLECAETGKNPEELIAVADKQKKKKKEKDPAGAGAGGTPKQEKHNEKVAAAAAAAAAAEAAAVAVAPPPQQPPSQMPQQPQPQQLPPPPHQTLQPPPPQGYSQQQPQHPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPI7</accession>
    <name>A0A914YPI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPI7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2748.t1">
        <property type="protein sequence ID" value="PSU_v2.g2748.t1"/>
        <property type="gene ID" value="PSU_v2.g2748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2748.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="18293" checksum="099581473DDD8E30" modified="2023-02-22" version="1">MEIIPATSITLPLIGKYLLFTMIMVTLSVIITVVILNLHFRTPTTHRMPKWIKVVFLRWLPKVLFMRRPIDESEESFRQVKHNKTIQNERIMINCHEHRVSRDLTRTLANAPIDERIQRLYYSPPVVKAFENICFIAELLKKKDRDDKVSFFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQB2</accession>
    <name>A0A914YQB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19549.t1">
        <property type="protein sequence ID" value="PSU_v2.g19549.t1"/>
        <property type="gene ID" value="PSU_v2.g19549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19549.t1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43557" checksum="CA8EC6F5EB81F95A" modified="2023-02-22" version="1">MDEEIIEINDDNNNQAPAPQIQPIIIYPPPQPPPNQSPPIQQPQSRPIPIPVQPPQIPKPAPISQGIQPSPAPLIIAQKPSTRPSVIVQTRAPPPPPPPPPQPVQVQPMIIYPQPLPGILPPWYPQQQFPPFPPFPPYPPVTRYPPKPVPKKTTTASIGNGVNKISTTTVKTTTLFLEDPDDVVGGGVMIPKRGRHGPQGQSFNQSTTTTLRYRPLTRSTETGTTMNSSTTFYDSTMFPTTTIKYPSVGEGVANISKTTEDFNFDKVTDPSSFNQPEELSSQDSDTDCCISLTAGWLTVGIFMFLSILILLACLYCMYYFRKKEKQKCRDAVKRYNDIYRENSKMPNFNSHFMPPGPAVMTPQVKMDQLTKNMIVCFFKFLYYYYQVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS77</accession>
    <name>A0A914YS77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">30S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YS77"/>
    <dbReference type="SMR" id="A0A914YS77"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20251.t1">
        <property type="protein sequence ID" value="PSU_v2.g20251.t1"/>
        <property type="gene ID" value="PSU_v2.g20251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_bS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_bS18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20251.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8959" checksum="6E681A5AB548A4C4" modified="2023-02-22" version="1">MSKFFRRRKFCKFTAEGVKEIDYKDLNTLRQYLTENGKIVPSRVTGTKSKYQRQLATAVKRARFLALIPYTDNHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSB8</accession>
    <name>A0A914YSB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2548.t1">
        <property type="protein sequence ID" value="PSU_v2.g2548.t1"/>
        <property type="gene ID" value="PSU_v2.g2548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DDT" evidence="9">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="979"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1066"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1139"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1244"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="979"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2548.t1"/>
        </source>
    </evidence>
    <sequence length="1263" mass="146204" checksum="B2C8CA775318D43F" modified="2023-02-22" version="1">MFTVAPEETILCPWIEEVNVPQLMLPRPCHDLIVDGRLLMDLIQVYETVTTFYRLIQLTPFIFEDFCASMRSENQTKLIADIHIALLKALLRDDEEQLTIFAVTETSVSFQILGQLLEPATYGEVLRQYAESDSRFPKEIVEILRSNYPFVSLGDRLKVLFWLCERLVESALVKKEIKAEGKILNESYCRECAKPGDLLLCDGCEASYHMKCLSLDDVPAGEWYCSVCRQQEVHGVTDCEISNEKGTIHRKTPLGYDRHGRVYWFLIRRIIVEDLAQNTVYVYSTIPAIYELISTIDASHYESRLCANIYRILDKIAEQCDITLKMTHFRRDELGQKLVGNKELEQTYIDKDNAHRMIYIVYNIVTNLSVKHEIMEIDESTQDGIQNNLPLKLERKILKYLGFENGILTSTTWSFGVEQEHLVERRNEFVAALEYPPDIKALPLLDDYCRELNIAFRLSFSDGGYRKYDNIYDSNEYAKPTIQRIKEKDRKKYMSTRFSLDEPFLWAVTKGKNMFVDQNLFGRHIQITLRRIVERLPDELYHRLWKGHNKEVFVSKLTKATTPELLRECLLQFEACLRKPAFTNAWWSSLGHTSLIRQTSHDRERRQFLDNLRKKEERELAIAEPSVVNDIVWVNTPRQKNICKNLWRMKNEQYRLNGKGALGGWMWISAQYTRDIVDSAEKPELGIDFQTPIEQLLTTASRKACRLDKLVKKFSCWREAQEEEALLRSQPNCFSPSCSKTSSFIKISGQKIPTKCYSYNCPKCTAEELDTQSQNPDTSAIAKAFDTVRRRAFFAELKKTSANTRGEGIPFPFPVPFHYTHPKTKQQSILILPKYTLKKLSKTGGVKSFHIHGFNRSQKSNYTVWPYLCHRPIFDNCWRYLTHHSKSLHSIALQLRILFASIRWSDLDADDFDEGESVIISHPDYDEKRFVIGHRENPPDGYYEQYKLRVELIALDDDGIPPHIEGDIELDKDKIDISSIPSSTPSSKSTRKSVRRKSKKLNDSALSLRGNVSRKFVERWTDGVQLKLFEIVAYWKRYNEKKPQIRILSKSTPSENRDLRLFSNLQGLPAPRRSSPPPSLVTVTDSRKRFHESDSPEIPKKVVILDEPETTPRQLPRIITIDRRKQDLSGSFIHRIAPSSSSEHRNVFPVTSSPSQNGSNVQRQLKIVRRSDGVRFPTSGTTNGTPLSYVNMNIRPRQPLTSGPRFVTVYRSAGPTPYRDIYRPSHAVRRILVHPPGRQVFMRPLRPTQIHSNQSQNPNDYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSU6</accession>
    <name>A0A914YSU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSU6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2733.t1">
        <property type="protein sequence ID" value="PSU_v2.g2733.t1"/>
        <property type="gene ID" value="PSU_v2.g2733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037356181" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="2">
        <location>
            <begin position="12"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2733.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13439" checksum="5B5C33880DF4B34B" modified="2023-02-22" version="1">MAFSASAAMALIAIIYRITVNLPDMPFSSNLKNKTSTDFNDSAQQVVDAVNFLIKPIPGFHNVTVKEFRYQQVVGTMVIMDILSTNTHDIESFKKLFEDSIQEGHIGWSHINKIYPKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSX1</accession>
    <name>A0A914YSX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g310.t1">
        <property type="protein sequence ID" value="PSU_v2.g310.t1"/>
        <property type="gene ID" value="PSU_v2.g310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00142">
        <property type="entry name" value="Shadow ORF (opposite yadG)"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00159">
        <property type="entry name" value="Shadow ORF (opposite uvrA)"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g310.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17095" checksum="358FDF4302DA8FF6" modified="2023-02-22" version="1">MAAFRTKVDDPVGGLDHVQVVLDHHHRVAFVAQLVQHAQQRFDVVEVQAGGRLVEDVQGTAGIAARQFLGQLHALCFTTGQRGRALAQLDVAQADVDQCFQLACDRRHRLEQLQCILDGHFQHVVDVEALVQDLQRFAVVALAMADIARHVHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSY6</accession>
    <name>A0A914YSY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3113.t1">
        <property type="protein sequence ID" value="PSU_v2.g3113.t1"/>
        <property type="gene ID" value="PSU_v2.g3113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="40"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="7">
        <location>
            <begin position="531"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3113.t1"/>
        </source>
    </evidence>
    <sequence length="773" mass="85564" checksum="C68D94FBE2B00244" modified="2023-02-22" version="1">MEEIGLNNMENELVFPSKHYMPKEITQQSEFLKKYPKYDGRNTVIAIIDSGVDPSLPGLQTTTTGLPKIIDCLDLTGAGDVDTSTIKKVDENGILIGLTERKLQIPKSWKNPSGDWHLGTKILYELYRKDIKDRINPSIIEDFKKKNKSVIAKELKELNDHEKKVGSKSKKILDKEDREEINTKLEYLKEAEKLEIQSPILDCIVWNDGEKWKAAIDTTYIGNLEDAKVMSSFCTDKEYGFISDKCLLTYCLNIHEDGNLLEICVPNGSHGSHVAHIAAGHFPDDPEKDGLAPGAQIISLGLGNAYTEQAFIRAFNKCIELKVDIINLSSDTPSNCVGSGKTEKLIKNVVEKYGIIFVAAAGNDGPGLSVAGFAGGRIHSSIFYVGAYLTAEMKEAMYSHFEADNSVVFPFSSRGPSVDGSLGVTFCAPGAALTGVSKHCLEGMQRKQGTSMSSPNAVGNIACLLSAMKDESIPISPFRIKLALQNSAMMPEDGSHHPFSLGAGIIQISSAFELIKSAAFLSIPPNITDIRINVGSKKLGIYLRDPSEIASPQAVIMDVKPLFMESGDNEARVDFGCSIMLKLASGSEKDFVKFPKYCRLPSSDFSVIVDPTKLEVGKVHYAEIVGINPQKQSLGPLFRIPITVIIPEEVTSENLYRYKKQLILEPAVPERIFIKSPFGCKYVGIKIKSLESQIAQNIRIQQIFLNQKIRCRLAKSYQRLLPKDLVFCHFISPENQTIEYCFTQEWSNQNVTNIKITIQFFGILVQPQIITDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTD3</accession>
    <name>A0A914YTD3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTD3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3421.t1">
        <property type="protein sequence ID" value="PSU_v2.g3421.t1"/>
        <property type="gene ID" value="PSU_v2.g3421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3421.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10415" checksum="BAB294326FF68181" modified="2023-02-22" version="1">MYFITERYFKSRFIKKDDQQQKADSPPQMRTAESPSTANPEEIQKITRESQEKATTKSSSSIQDSSDTASYNNASKNDKPSMDVSGKKNLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTN3</accession>
    <name>A0A914YTN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTN3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3352.t1">
        <property type="protein sequence ID" value="PSU_v2.g3352.t1"/>
        <property type="gene ID" value="PSU_v2.g3352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038030944" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3352.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="12712" checksum="308FB9A4185AB3D0" modified="2023-02-22" version="1">MSVLKFIICIIFSFFFILIKADDGGLSDIPFNGTPDQVQDAYRTKLAVELAEKGKIPLPSSRTLAKVGNAGIFDSPTGGTGGVAANPVFATLGGAPAAATNRLVGVRTGGTNTYSSVYNAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU11</accession>
    <name>A0A914YU11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4143.t1">
        <property type="protein sequence ID" value="PSU_v2.g4143.t1"/>
        <property type="gene ID" value="PSU_v2.g4143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4143.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26292" checksum="6E475D5D5E063A04" modified="2023-02-22" version="1">MDVPKDSVSSDNSTLENSEARLPPTNAFPTDQMQPSNAGINIPCEKCSQIFVSMKLADAIKLSNDIKKLEIMIKNKPPGRPLKNFIKSQADGSRKMATTKYGKKIDQKRRELKKNAEDLMETNKALKEMIKVNQSTFSPVQKQQIVEILYKECNLLKESTSEIDDNKEIRLSQTPGATAKRRFDRKKRNEKADWEKKVQVLPMIHKELHNVFGVIDWMGIAASKTAMSFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU83</accession>
    <name>A0A914YU83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21028.t1">
        <property type="protein sequence ID" value="PSU_v2.g21028.t1"/>
        <property type="gene ID" value="PSU_v2.g21028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21028.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17030" checksum="2D3D6D9C9767029F" modified="2023-02-22" version="1">MDDDFNYGDDAFMYSQGMEFSFLNEPEPEPQPLSPIKKSPRKNQRFGTSSEMHKSFCSPQKKDISIIDLSESPLFARRPLSNTGSPIPSKRPPSISGSPVFAKRPPSINLDDPTTFSKPKELKFNIPENVPFSELDDEVSELISFNRNKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUG3</accession>
    <name>A0A914YUG3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid-binding serum glycoprotein N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUG3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3305.t1">
        <property type="protein sequence ID" value="PSU_v2.g3305.t1"/>
        <property type="gene ID" value="PSU_v2.g3305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF144">
        <property type="entry name" value="BPI1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3305.t1"/>
        </source>
    </evidence>
    <sequence length="486" mass="49890" checksum="A8447199810FF078" modified="2023-02-22" version="1">MACLIATALSQNHTHRPVQHGFTTRQRSLGAPSRIHGVQQGYAGPYGGGGAGGGGGGGGLAPQGGGGGGDFAPQGGGGGGDFNPQLQACGRGNPGIKARINQRGFQYFSSLIAPILDQEIKRAHIPPINQCIPEVSGCIQVYNLFVSRYRCPQRVIIYPGPPNQIVIAVQNLDVGVTGNLGGQINIILPLKLFGIVQVNAHQVSITVQLAITRGPSGGPYVSVVGCQASVGYLDAYIQNGGLIGDIANSQFRGQISNRVRQMIPSQLCAQIPTIVNEKINGQLGALPQSIALTQILQVAGGALGLGGGGASGISGGGASGAGGCGGGASPGPAPQYPSTPCHSAQKTPQLSKPLPLPPPAVIAVTKKPQILPPSSKPSSVPASFSTAPRAQTSSQKVPYYNSNNPPPPPTYAAGVPPPTARSLPQSSNSPYSKRHVILSNAPFINYHPISNTRFINSASTDPRVANRFIRDTRPHGHLSPSSPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUR2</accession>
    <name>A0A914YUR2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUR2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3876.t1">
        <property type="protein sequence ID" value="PSU_v2.g3876.t1"/>
        <property type="gene ID" value="PSU_v2.g3876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF354">
        <property type="entry name" value="GM14138P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3876.t1"/>
        </source>
    </evidence>
    <sequence length="439" mass="49137" checksum="4D1DD7A5117E07C2" modified="2023-02-22" version="1">MLAKVRSVISPRGQPPPKPSSEEASSSQIPPPKIGMVVDMADTHYIGGLIPVITGSDKLPHPYCRPEFLYLTEDEISLSGDQSIRPVMTPKYPTQMPVYAGYAEVINTGKSKENEDMAAAKVLNFVQQGYEAEKAVELEDKSKDLNKKKQEKLQRKPSDDDLLVISQSFSSDDGPVAPKAEAAFFGLFDGHAGSGAAIMTANCLHEHIKSRLNEVLESVMHLNRQEQLLRASRKSSFYSMENENWEEPKHQASINSDSLVIGALEAAFVDMDEQIAEEKTYIKVTGGCATIVSLIFLGKVYVANAGDCRAILITPNKVLQLSNDFNPVHERKRLQYIAYQNNDIISQHFSRLEYSRYLTSKDLNRKVLFRDWYMDGWAAKTVREPDLKPPLISTRTRKPRLLNTIGVCRGFGDHHLMTADDKIAIKTFLSPFPEVSFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUW6</accession>
    <name>A0A914YUW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUW6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21282.t1">
        <property type="protein sequence ID" value="PSU_v2.g21282.t1"/>
        <property type="gene ID" value="PSU_v2.g21282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036972699" evidence="2">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21282.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19055" checksum="BD13E7AC4ACE8C6C" modified="2023-02-22" version="1">MLVFNLIIIIRIYGTSHQTTSCSSDVGSSSSPDYESFPLIKSETVVCDNFVLNNRLRARNTIFGGSMRAPRPTSGCHPHPSLRNSIRIRPPPLQGPSPEEDIYSLCGSERGIDVPSPLIPNGSIRHTRSVSNAMSSISVTTVNRASYALSKQSSKAIIKPPPPYPGRVMVSFMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV05</accession>
    <name>A0A914YV05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YV05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2133.t1">
        <property type="protein sequence ID" value="PSU_v2.g2133.t1"/>
        <property type="gene ID" value="PSU_v2.g2133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2133.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18482" checksum="B763838969CA8907" modified="2023-02-22" version="1">MILDRLGHRSPIIMALLVSSLFSLFIYADIGDSKILNVLMMTVLGVTISGPYNLIVGTIAVDLGSQPALAGNEKAMSTVTGLIDGTGSAGSAIGQFFVPIIQNSFGWSWVFYSFIIMNFLSVLCLVKRFYIDSRIVVQNYRRRGTISMRQRLLEDEPLLSSATISHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWE8</accession>
    <name>A0A914YWE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWE8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2407.t1">
        <property type="protein sequence ID" value="PSU_v2.g2407.t1"/>
        <property type="gene ID" value="PSU_v2.g2407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2407.t1"/>
        </source>
    </evidence>
    <sequence length="653" mass="77051" checksum="9D408FE29D426E8B" modified="2023-02-22" version="1">MDVYGKVKKLLIVLNPKNKKLCYEYYWEQKCQYFVCCGCVINRKTCVARYHKNDKKDGDEYVTFGRAPHVCEWRKYDIEYFFKDRKRIDSTNFEVHEEIKNGVERKALIILSESDKTKCYKLYYTAASKCFSCLECKKLKHCVSARVFDDPIDKKQYAIPGKNDHICNLQEYIPAKKIDDEIVESSGFLKLQNQSGPLKIIVFDQKNKKLCYEFTCRKGTNIFSCLGCHEKDNRKLEGNALIQLCTRENGEEYLTLKKWNHCCKMRKYEAEKFQEIIFREPDFIFYREPKDPIINLAIFCSNDKEKFYKYRYHPSQLRFCCLNCRKIKSACNNFAKVCQDENGKEYLYHGKFQHICKPIPYSTITKNKNIEILKASGLPPKKPSKSGGRPCNKNIPPKNIDKSRIIKAEDFELQWSKKGKPDGKLVIFCPENKKLCYELNHEERNLYRCNKCVLYPSDYHITEMDENEDPIKFVIFIDADKKKCYTYTFWTIGKIFRCRGCMRSGTMVNAKIYKDKNEKNYMKLSPNNHVCVPEDYVSEGKDILPPQRFTLMPSKNGTVNGKLFLFDLEKPFYGYWFNFSKTVYYCCSCRKEGKQVKAKLCEKDDGEKYVEMYHHPKHVCEIRNILEENKVVKAENFKIDTNSSGEKPQFVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWU6</accession>
    <name>A0A914YWU6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWU6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4576.t1">
        <property type="protein sequence ID" value="PSU_v2.g4576.t1"/>
        <property type="gene ID" value="PSU_v2.g4576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4576.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18904" checksum="121C9B5669616F2B" modified="2023-02-22" version="1">MNDMGDIRKLASIYGPSDLYLMMTQYDEDMLIPQPDEELDIIHLSSQTSLKTDLRIQKTNFDNEIIQTEALTTDKKADLNKTIAPFDEEIEILETSSTYSSVKPDTNIRKADEENVQTSTPPKTLTMSAKTRKIAARLGSGVKVIKVYDVTPMPTYEKYTDDELKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX31</accession>
    <name>A0A914YX31_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YX31"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5079.t1">
        <property type="protein sequence ID" value="PSU_v2.g5079.t1"/>
        <property type="gene ID" value="PSU_v2.g5079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000283">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF88">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5079.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29726" checksum="82319D43128FD897" modified="2023-02-22" version="1">MNNGQQQQQQYPQQQQQQQPIRMQDQSSQQQGSNQMGMPSSSSSSQQQQESSNSSPGPALIDETSRWKKCDATNQSIYDFQIESLNGTFTDLSAYRGQVLLIVNVATFCAYTQQYTDFNPMLQQNSANGFKILAFPCNQFYLQEPAENHEIMNGLTYVRPGNGWKPHNDLHIFGKVEVNGENNHPLYEFLKESCPQTVDRIGKRSELMYDVIGKNDITWNFEKFLIDRQGRPRVRFHPTAWSHGQVIEPHMQELLAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXC6</accession>
    <name>A0A914YXC6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hypoxia up-regulated protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXC6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2746.t1">
        <property type="protein sequence ID" value="PSU_v2.g2746.t1"/>
        <property type="gene ID" value="PSU_v2.g2746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2746.t1"/>
        </source>
    </evidence>
    <sequence length="519" mass="60075" checksum="0CF14552176D74BA" modified="2023-02-22" version="1">MLTSNLLDVDDYDPENEEDIIPITRDEFEKMAESYKVRITKVIFQSILKAKLTKEQIEYVFQVGGGCRMPMIKQLLLSTFPNANHQCNLYPDWVVAHGATLYAYHLENLKRNQQTKKYKIPSQCETYDPTFNAVGIDFGTTECCAAVVRKDGPYSILLDTCINLNRVMPLYVSFAEGQALFGQLVINRMKYFAKNSVFDIQKIIGKDFEEIVHNSLWPFKLVKNKEKVFIEVETVNGRENKSPEEIISLILEHVKTKIETFQDLQKFSRAFHVVLAIPFSYSERQKLSLQRAAVMAGFNSINFIPASIAAAFAYCAKNNILDQSNILICECEEGSTELCIAKMDTNEFEILSYENDSHLGGEDFDRLLFNHFDAILKRKYEINVTRTNAKYDLNQICRKIRHELFFRNEAWLHLDDFIFDNEEQIKITREDSENMSAELLLKIKRIINRVVLKANVSKESIRYVFHVGGGCQMPMIKNLLLDTFQMAYHKFHEYPEEVVAHGAALYAYHLQRSKIERGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXQ1</accession>
    <name>A0A914YXQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXQ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4737.t1">
        <property type="protein sequence ID" value="PSU_v2.g4737.t1"/>
        <property type="gene ID" value="PSU_v2.g4737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037955248" evidence="5">
        <location>
            <begin position="23"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4737.t1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43219" checksum="9F691E08463FFE95" modified="2023-02-22" version="1">MAFKFGQILCLLFLAKTFATDAEIETLDFDFFESLQNEPDKVVKDLQSSDPDIQLKAIVEVQTLFKQKEYLDEFVENEHLPILIKCLNSENTTIQLEAIKALSEIVISSVRNVKEVVREKAVPHFIRLYHSSNSSISAQSIRTIGNIILKDSRLRASILKLGLLDHLIEEPIESFEVLNETVRVMLILTLDKDHPLPQDVVERLVPVFEVLLLHSNFDIVKYATWAFQLLTAADNSRHNIFFDKDTIKLLINLINHREPEIQSAAIGVITNVVNKKNEQSKMVMDYGILKVLPKLLMHENDETVKNALTLLTNLFDVSYSKTTLIFDKEIIPLIILHLSRVTNDEVQEEAANAITSATKFSNPEQISYMIDMNIINAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXR4</accession>
    <name>A0A914YXR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4893.t1">
        <property type="protein sequence ID" value="PSU_v2.g4893.t1"/>
        <property type="gene ID" value="PSU_v2.g4893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4893.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32808" checksum="A0B4866C56449BEC" modified="2023-02-22" version="1">MNDQSLPQNLSDEHLHRLAPTPTWSPPPPIDLSLVQPYDSFDDNYQDNDIQVYSTLSPANVSFRNTYQNSGSAIINDSYFSPQVIAINEAPLHHPYGTKNEKEEAKKESNRKSKAYERGHKNRIEDSHISNDKLINGIKQQFRSWNGEDFYLQNLLQKLFNEYKPFPVKKRRTKTTTPQIGNLNDVPSSSVSPYNLSRRINQLGFCENPNIEHHCGIEFHSLSIQSNVEIDEERRLAFDDDENADKVQHPCGNTSDESEDANDSESESSDIFSELGDLFELFLSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z024</accession>
    <name>A0A914Z024_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z024"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3630.t1">
        <property type="protein sequence ID" value="PSU_v2.g3630.t1"/>
        <property type="gene ID" value="PSU_v2.g3630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF326">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER SNF-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3630.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39282" checksum="FF98352A41D0519D" modified="2023-02-22" version="1">METLGGINYKILVCYAIAWIITAICLRKGVKLVGKLAYFTATVPYAIIAILFVRSITLDGAKTGMDYFILKPDFSRIFDPTVLRNAASHICYSLSIGFGGMISMASYNPSHHNPYATAATLTIADGLMSLFGGLSVFSVLGFMSKQLNVPIDEVIQSGTGLAFVAYPEAMSRLPLPWLWSFLFFVMIWILGVSTQFGFVETSFALMVMLFAEIILVCHVYGIKNYIYDLRSMLGNPKTKFAEWFGPTGYYPAFIWTVISPIVCVIIFVLALMTQITHNMTYGKGSRIYVYPDWSIAFGWSWRELFRLQPKWPSYSRHQINGTGGTANSGRVGIADPHQSVPKEFSSKQQTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z096</accession>
    <name>A0A914Z096_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z096"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5597.t1">
        <property type="protein sequence ID" value="PSU_v2.g5597.t1"/>
        <property type="gene ID" value="PSU_v2.g5597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="94"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5597.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23402" checksum="5F8566E1B7A05C0E" modified="2023-02-22" version="1">MTNSCMPEVSPGSSSGSSGVSSSSDLQRSLPLPPPPQQQPRIHEVQIRRIPTNNRPSTKRTSLNGLPRMGISSSYPLQNTTSSLERIIRTHPIWYLPHLGRAAANHLLRPMPAGCFIVRASTRPSSMALSIKLPPEYGTDTDHYLLERHGASTVKLEGSPHIFRSLPLLIEHYCQNADELQCKLTLPPAIQLCSNTIDLQRIALMGQGKREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0Z3</accession>
    <name>A0A914Z0Z3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cathepsin propeptide inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0Z3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3941.t1">
        <property type="protein sequence ID" value="PSU_v2.g3941.t1"/>
        <property type="gene ID" value="PSU_v2.g3941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="2">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3941.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25956" checksum="805CC052F5C37F1E" modified="2023-02-22" version="1">MIFLVITQQLLNKELARENERLRKSGAHEFIDNELLSHPYFEKYGNEFEEFKQKYEKYYETKHEEHRRKLIFLNRMQQIDELNNDESNLLGNSYASNQFTDMTDDEIKKYLMPLDYYSNLRKHATFLRPIDNDFTETAVNHPPRFDWREKGVVTAVKTQDYQGVHCGSCWAFATAATVESAYAVAHGELRNLSEQELLDCNLENNACNGGDVDKAFSYRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z101</accession>
    <name>A0A914Z101_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z101"/>
    <dbReference type="WBParaSite" id="PSU_v2.g640.t1">
        <property type="protein sequence ID" value="PSU_v2.g640.t1"/>
        <property type="gene ID" value="PSU_v2.g640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g640.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="13826" checksum="21B1A198727B0D18" modified="2023-02-22" version="1">MDVDQLVVVAVDEIAVHVQYVGQAAGEAGAEVQADLAQHQYHAIGHVLAAVVTGTFHHRQRAGVAHGETLTRAASGKQLATGGAVQAGVADDGGAARLEAGATRRAHHQAATGHALRRNRWLRLPLPGAGHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1P9</accession>
    <name>A0A914Z1P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M13 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1P9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5821.t1">
        <property type="protein sequence ID" value="PSU_v2.g5821.t1"/>
        <property type="gene ID" value="PSU_v2.g5821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="94"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5821.t1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35606" checksum="C5AA8A5997F53D40" modified="2023-02-22" version="1">MLDDLPWINQDKKTQQSARDKIMNLQINLAYPNFIFNNTQLDIYHSQLGADFETLNYFEMLKRLTVFNQYQNYINLTSSHIDRSNFLGPPGTVNAWYQPELNSITIPEGILQQPYFDPDWPASLKFGAMGLIVGHELTHGFDDQGVQWNGEGILKPWMSAEAQTTFTNMAECVVDEYNNFTAITNSSYNPQNINGEQTQGENIADNGGIHSAYLSYQRWIQLNGPDPKLPDSNYAQFTHDQLFFLSFAQVWCQTAPSDETTYKQLLVDPHSPSKFRVFGTIQNFPAFQQAFNCPLGSNYAPKDHCSVWVPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z325</accession>
    <name>A0A914Z325_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Thymidine kinase</fullName>
            <ecNumber evidence="12">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>thymidine + ATP = dTMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19130"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer. Tetramerization from dimerization is induced by ATP and increases catalytic efficiency due to a high affinity for thymidine. Tetramerization is inhibited by phosphorylation at Ser-13. Interacts (via the KEN box) with FZR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z325"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7100.t1">
        <property type="protein sequence ID" value="PSU_v2.g7100.t1"/>
        <property type="gene ID" value="PSU_v2.g7100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001270">
        <property type="entry name" value="Thymidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="THYMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441:SF0">
        <property type="entry name" value="THYMIDINE KINASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7100.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19668" checksum="47142B8C78E874D4" modified="2023-02-22" version="1">MATNDQCYCRQNGGIHLILGPMFSGKTTELFRLSTRQNLAGKKVGIVKYARDTRYDENMASTHDCKKMEAIAAEKIADIYDQLLSYDVIGIDEGQFFSDIVDYAEILANRGKVVFIAALDGNFAREPFECISKLLAFAESACKLTAVCHNCGKPAPFTYRKIEDEQVSIHPNHFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z396</accession>
    <name>A0A914Z396_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z396"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6834.t1">
        <property type="protein sequence ID" value="PSU_v2.g6834.t1"/>
        <property type="gene ID" value="PSU_v2.g6834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="448"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6834.t1"/>
        </source>
    </evidence>
    <sequence length="573" mass="64097" checksum="365349AECA974F13" modified="2023-02-22" version="1">MVAAISCPATISSLDEESRDKILETVNRDRELIRRGELVLTNGENALQGAFMQNLTWDCNVEANVAVKAEALCNGSWGQYSFFEVPYTVSLYRYGNVGNPIIDHVNFWTSSESFNASTYIQLASDTRYLLYSKQFTSYYLSDVGTTLGCASYQCPAKNWTQLICKTSPSVTINETIYVSGDPSVVTTPVPEPVCSIPETFLTSAHRTKLINSINEKRSQALNGTLRLYDGKFALQAQQMPMLTWDCEMEAQVSKVIEERCTTAALSARPNESTWYDSETYNTIDYYVHEFSKTNIDEVGFKFLSNTTYGTFGRNVIDARVLHDKATKIGCAIFQCNHIVAGKPSPLTNMICTFDVNWTPLTNGTRIKIYEPRTSVSTTLPPVTIPSEIQTTTALNTAPPTGESTGYTTNCGDSTVASTPSQQIVTTTVEPEANNCSPGYIYFEPTHSCYGRDPELGLTWNTWPKAEQYCEKQGGHLASIHSEEENRLIVSLGAIHGWGVWVGLYSVDENYTWKWSDATPIDYVPWFYGYDHPLYPDVNISCVYAYPYYDPRGSLVNDMCNNKQYFVCQLPAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4A7</accession>
    <name>A0A914Z4A7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hcp beta-lactamase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4A7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5086.t1">
        <property type="protein sequence ID" value="PSU_v2.g5086.t1"/>
        <property type="gene ID" value="PSU_v2.g5086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040239">
        <property type="entry name" value="HcpB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5086.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28920" checksum="4F9DAFF5B63A94D9" modified="2023-02-22" version="1">MSTRLTKEEILAELEETQKERREYVKNIGIEYRFGCLEEKRGDSCHLLGEYMEAIEQNYKKSYELFRDNCEIRKYPKSCFKYAMYLLNGKECEPSFIKMLKPLEIACADNLPPGCRYLGLVNWNGVENQKPNSKKSEEAMKKACDLEDPEACWMLSTWYLGSQTKFKTKGKDLDKQKQLGELEKNPERALEYGIRACEMNVPQSCANVSRMFRIGDGIPENVEKAKEYHDKAAEIITLLKSRNANAGFTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4H4</accession>
    <name>A0A914Z4H4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4H4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6896.t1">
        <property type="protein sequence ID" value="PSU_v2.g6896.t1"/>
        <property type="gene ID" value="PSU_v2.g6896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705">
        <property type="entry name" value="AGAP000321-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705:SF1">
        <property type="entry name" value="PNP_UDP_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037732842" evidence="1">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6896.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26535" checksum="A77A366DFE77A9E4" modified="2023-02-22" version="1">MFLFLVLGVEFLITQVHNLIFKRNREDFHNIVNDVNVRYWGPKANVLAKTVEGFSENDTLRWHQSTEKLVESLKVNNPDTNFSRPDEDVLALPISGGGVVVVNHPDTRNEPILHLAPIGAICSIQYPKKQENGHDESYENGTNGVQHNEMDSEEAWNQSIYKVRQDFIAKENLRALDAGFDSVIAAIEGSRIDSWSVVLGIADYFQGNSRGAQEWKPYAAANAASLLREAILRFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5B7</accession>
    <name>A0A914Z5B7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative H/ACA ribonucleoprotein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5B7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g754.t1">
        <property type="protein sequence ID" value="PSU_v2.g754.t1"/>
        <property type="gene ID" value="PSU_v2.g754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="179"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g754.t1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37222" checksum="6103ED560CC82D0A" modified="2023-02-22" version="1">MKCGTLDPKVSGVLIVCINRATRLVKSQQSAGKEYVCVFRLHGDVKDTKQINQALEKLVGAQFQRPPLISAVKRQLRIRSIYDFKLFDYDADKHMGVYWVKCESGTYVRTHCVHLGVLLGTGAHMEELRRVRSGVTSENDHIVSMHDVMDAQYLYDHHKDETYLRRIVRPLESLLTGHKRIIMKDSAVNAICYGAKILVPGILRFEDGIEMNQEIVLVTTKGEAICLAIAQMTTSSIASLDHGIVAKIKRVIMERDTYSRKWGLGPYASKKKELITSGLLDQHGRPNAKTPKDWSSVYHYTNKEASGEKSKKSKKVKEEAMEEDEEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5J9</accession>
    <name>A0A914Z5J9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5J9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7173.t1">
        <property type="protein sequence ID" value="PSU_v2.g7173.t1"/>
        <property type="gene ID" value="PSU_v2.g7173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007026">
        <property type="entry name" value="CC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04942">
        <property type="entry name" value="CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042091447" evidence="1">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CC" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7173.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="13921" checksum="75587914667A9608" modified="2023-02-22" version="1">MVKNVMKLTIFSVVIIVIACVISVEGCPAGQTAVGPCIGNVCPLGSICNNGNCCNSAIGPCVGGECPPNYTCSNDQCIGGNRACPVGKVALGPCIGNECPSGSICDNGNCCGNKIYGPCLNGICQPGAICNGQQMCEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5K0</accession>
    <name>A0A914Z5K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IRG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5K0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7959.t1">
        <property type="protein sequence ID" value="PSU_v2.g7959.t1"/>
        <property type="gene ID" value="PSU_v2.g7959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF17">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="6">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7959.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17608" checksum="D407A014FEDE9E57" modified="2023-02-22" version="1">MKNAHTDQVVGLLTQHLSQRNEEVERLTADLKHLHTEFNNSKDNFVTYFKEKPKSDIEVPKHLKKIIEKAKKDLNLDTKNFYNIAFVGHTNTGKSSLINAIRGIDDGEKGAAPVGDVECTMVIEPYTFADPQLKHVKIYDVPGAGTISHDALNYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6R2</accession>
    <name>A0A914Z6R2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z6R2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5937.t1">
        <property type="protein sequence ID" value="PSU_v2.g5937.t1"/>
        <property type="gene ID" value="PSU_v2.g5937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5937.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25184" checksum="4AA9ADE8D0B46346" modified="2023-02-22" version="1">MPIPAWIKNAMEEFERLFVNYTLTLYGFLPFKTPQINNLQTELTKVSSGALMAEIYDRLSLKIKCQNSIITAAEFRTKECAEINSQKLYTYSTHDLTVVSLFAGLGFKSFLFEKYSMPAFGSTVTIELWKHSETNDKNNNQLLSEQNYYIKIYYYKNFYVKNPINLAEMLKPECTEKGCPFMYLKKRAELLRPQPDWKGMCSDRVPPTPTPTTTIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8G2</accession>
    <name>A0A914Z8G2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z8G2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8141.t1">
        <property type="protein sequence ID" value="PSU_v2.g8141.t1"/>
        <property type="gene ID" value="PSU_v2.g8141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="268"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8141.t1"/>
        </source>
    </evidence>
    <sequence length="563" mass="64295" checksum="51AA8FDC91DE4B53" modified="2023-02-22" version="1">MFPTLFFRDRELFVFDDGEVAAHNFGNYQRFLNQTFTTKNNLTNGKIHRFLSDNERNGRYDGNKIGGINFVSATIEWIENVCKQPIDENNTLPNICIIELTYSGIIGEHDLTLFNLALNHFKDKKNQFMHIHISRIVGGHSDGILKSIQNLINIRWAPDMIVCRSNHSISDKVKEEIARHASLQTNQVINLVEVENINYVPLLFQHTNVYSMIAEKLKLEYRPNKNNIMQEWSEAVKLADNYKNTIKIALVGKYFKNPVAINGNQIFRDSYASVINALNDAGLSTKCKVETIFVWAEDLEAVSHLEKQLAAKKLLEEANGIVITAGFNVPGFEGMMEACKYAREKKKPLLSICYGMQCAVIEFAQNVCNIKGAWSTKLWQEQNDKCNNELPPLKPEQKVIIRMFEGGNKFGRLRLGRRTTYFIKKDSASYHLYGKKSSIQERHRHGYEVNPEFVPKLVEAGLLFTGMGVDERSGNSDNMPESSQILSIIAQDDKINYDQKIQTLCNYSITNNTPVRMEIMELKDHPYYVGVQFHPEFQSRPFEASPPFMGLVLAALQHFTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8Q7</accession>
    <name>A0A914Z8Q7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8Q7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8223.t1">
        <property type="protein sequence ID" value="PSU_v2.g8223.t1"/>
        <property type="gene ID" value="PSU_v2.g8223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8223.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35639" checksum="79B5C951A1D980D3" modified="2023-02-22" version="1">MLFSNLYQLLHERFKPRRQHIQLKDEYDLQNLAFIEYPMGDYLLRISSNFTPSTNCLFFTSWPKTVQLQVPHHSTAATKASIEAPPNYEIFDEKCVAEKRCETLNQESGISFPDKGIVEFAMALIDQKKTFELFHPSGIHSPIYTIEGIFSCTDYTTNISFNDLGFILFKRKSDKIDIEMEFKPNAQNELGDKNLISRESNIQFYFYKNLLNIFFFDPDDNFRMRTFILPEGIIEKMENSTTKIHINHTNADTFCSPLGNNVKLLLPKYAKLTSTNPPISKSTVPSIFETTKDASSMASFPLAAIIAICW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8W1</accession>
    <name>A0A914Z8W1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8W1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9109.t1">
        <property type="protein sequence ID" value="PSU_v2.g9109.t1"/>
        <property type="gene ID" value="PSU_v2.g9109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ESSS SUBUNIT, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9109.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="21234" checksum="EEBC698CB46C5D0F" modified="2023-02-22" version="1">MLRILKPYPRQVLAVRHAGGHGHHEETNIERKPDNYRPGSDSYAYENPWPKLNSGRLDWLFQDGWRRPLAKDQGAKMRREWLWFGQSAHDEHSDWYRFHYMSFFAFTVMTMWLTWWIVILRPDWPQGNEWALREAHLEIVRRKKAGLPLISKDLVDPQRVALSLPSDEELRDFEILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z951</accession>
    <name>A0A914Z951_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z951"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8855.t1">
        <property type="protein sequence ID" value="PSU_v2.g8855.t1"/>
        <property type="gene ID" value="PSU_v2.g8855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8855.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="9756" checksum="C40E965EE725A6C8" modified="2023-02-22" version="1">MRFLGGDYFPGSAAGERRDYLASLFCACFLNPGDPIRVNAAFICRSGVNCGYHGAYLRRPLGERHDYRHGGRMGYQRLGEETSPALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9E9</accession>
    <name>A0A914Z9E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9E9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g93.t1">
        <property type="protein sequence ID" value="PSU_v2.g93.t1"/>
        <property type="gene ID" value="PSU_v2.g93"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF82">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="62"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g93.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27350" checksum="609C9A3CCFBA1504" modified="2023-02-22" version="1">MTVPPITSLQECSDTGHGTLICAGYSKEIFVRNVYPPIQELQSRVLFVVIIFVICFIVGICGNASVWTIIRGILNERKNSRSLQRRNRDNAILYIAALCVVDFLMSLSLPPAILDNIIGFWMFGTFICKLHHVCGSVGRIVSTFLITAMSFDRYMAVCHPYKQWYRSKKFVLSTIFTLWSVAFILLLPMLFYAKANELLLHQLQHNEESTGIENVTRVRVYKCSDMMPPYIFLWFTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9M4</accession>
    <name>A0A914Z9M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9M4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8504.t1">
        <property type="protein sequence ID" value="PSU_v2.g8504.t1"/>
        <property type="gene ID" value="PSU_v2.g8504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8504.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10905" checksum="5847F0454437C9AD" modified="2023-02-22" version="1">MSINSITGSTTSDSSPFKAAHVKITVKKGYWYFAKLKTVTGIHSHAWTQQQLDNQDPGVDNFKASINNFNTRIPTILKEITIGEQKAFDKYDARDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAF2</accession>
    <name>A0A914ZAF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8762.t1">
        <property type="protein sequence ID" value="PSU_v2.g8762.t1"/>
        <property type="gene ID" value="PSU_v2.g8762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF9">
        <property type="entry name" value="CATENIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8762.t1"/>
        </source>
    </evidence>
    <sequence length="519" mass="58999" checksum="BAF2B43A9724F2AA" modified="2023-02-22" version="1">MLEIQKIMDKTDRVKNLIDRISKARTADELTEIVKDLHLEMQELTELTKKRLKDMKSDSEKDDLQVAMALLKITTPIMIASSKAYIHHPELREAEYNRNYAMTEMRDALMGVKCALNGEEVPSHIGISQKGYLNDLVNNLELFDRKIYIPHKSYQENTNRPQLEELLEKIVSGAARIADFSDTRHSRKGQIVDATNNLRDALQRLLNEYEQNVRLSEPSDDLGYCIENVVLKTRDLRRHLRRAIADLVSDAFLDTKTPIRMLIEAASTGNEDITIQQAHFFKEHADRMVAQRICEMSTDQDANRVVRYAALCCERLIPQVIHAAKLLCEKKDSPFTQENMAVFKSTWEDRVNLLTMAADRMISVVDFLAVSEAHIQEDTKQAIQGIVEKDPDTIDRAAGAIRGRSLRVCEFVDSEMDSYPPCAYADNVRMATRILRDSVLPTFVSKATKVVNAVSHHASEMSPEETERETDEMISACELIDNAVKDIRTAVLRNRNPEDVDSDNEYIEDGGTTAIDNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAI6</accession>
    <name>A0A914ZAI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g726.t1">
        <property type="protein sequence ID" value="PSU_v2.g726.t1"/>
        <property type="gene ID" value="PSU_v2.g726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g726.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10852" checksum="156F818EDB511898" modified="2023-02-22" version="1">MAIRCSDLDADEKHNLQEIVYDRLAFCSSILQDLFLLLDPVERGATLEPEKQNLVMQHVRETFGVHPSLVGIVKEFRQWIFESRYFSPGLSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCV4</accession>
    <name>A0A914ZCV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9520.t1">
        <property type="protein sequence ID" value="PSU_v2.g9520.t1"/>
        <property type="gene ID" value="PSU_v2.g9520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF185">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9520.t1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38409" checksum="E6E58CF7F6DA1A46" modified="2023-02-22" version="1">MSSPTGFLNQENPQLLQNRSNSQNSIPKNPKLYKTELCRSWMDHGRCNYGERCQYAHGTDEKRQIPRHPKYKTEACSSYHKTGYCPYGPRCHFIHNEDPALLQQLIAQNAAAMGTLGSEDSSPTLTPTLAQRPRNLNLQQTMSAPPSTVATPQQPHHQGHQHQQCHRQYSTILPIGSRPSLPQTPQQQQYFVQKQLGSDGESPIPSSTDSGSESPLGSFSPGLEESLCRLSPTSFRRSLSTTTTRWSPTSGISPATTISTTNSSAAVTGNIVNIVGGGMFNNANDPWKDSSLINSLSSLSFGDHHQQQHHHPHTPTTPIDNPWESTKSTNIISPAAARLPVFERLSNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD85</accession>
    <name>A0A914ZD85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Paired domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZD85"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8224.t1">
        <property type="protein sequence ID" value="PSU_v2.g8224.t1"/>
        <property type="gene ID" value="PSU_v2.g8224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF52">
        <property type="entry name" value="PAIRED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="10">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8224.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27874" checksum="CEB8FC9A4ECFCEDE" modified="2023-02-22" version="1">MEFDDLFIQRKVNKFGGYYFNGKPLSLQIRKEIIRQLNDGIGVTQIGRNLQISHGAVSKIVQIYRATRSIEPKIRSSPYNRKASLSSQKKSFRFSVNEILIDSLPQKHRNSFTEDQKAVLLENFEISPVPDQTMKEEISKKTGLSDKQISAKTSFVTTDTERSPSCESSIATTAKLSSPTSPCYSQISSIPLPSTSSPLSQMLHLSPQFSLLPTSHMANMNYMLQLQQLLAAQYYLTTLMQQMPQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHQ6</accession>
    <name>A0A914ZHQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9836.t1">
        <property type="protein sequence ID" value="PSU_v2.g9836.t1"/>
        <property type="gene ID" value="PSU_v2.g9836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9836.t1"/>
        </source>
    </evidence>
    <sequence length="603" mass="67860" checksum="2C6818FA1C9BD427" modified="2023-02-22" version="1">MFENCDENQILEWIDVVFGVKQNILILLKDEEIYKCIEEVQRRQPNIDFSLIDKEIRAIFRSLFVDCLNFKGIIEIYRILLYCETHTKCSTVYWKAVTELWKKLGNENSLNLTKNKKATIYPEHESLLELVKSYEECQCEIVKDLIKNLFKTSVTVVCKCKTNSEKIEARGYTIYLSTINDKIEELMNDEIREIEINAQEDIIFDQDIYLPGKNLILIAKNRLVFLNPQVCNLSGKMAENDILISPQIGRKMGEDGLDGKDGKAGQSSGNILISAKTIEGKDNLKISLNGGNGSDGQDGGDGVDGEDGKGKDFDTVFGWAYTFSKGIKYLTLGAVPRMLDNTLREKVDKSGANHITSDSAYYLLTHTIELYGGSDGKLGGRGGINGCGGEGGKKGSYDILINGERCDNIFEICAQNGKDGRRGKPGQNGRMGLDGWDIALTAKAFGDRQEFGKMKNEKLRIIYSDYRSPDSVYVKEKDKGIGSQCYAKIISSPCERKILRDQQVEVKTDSERSAEACATKSKPIDIEAISQQQLTTAQVINVENEEEQNANSEIERYHETGRIMDFYKPLEIDNYVFKQRHHTPIIIDEKLEGSSPFWTLTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSA6</accession>
    <name>A0A914XSA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSA6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10866.t1">
        <property type="protein sequence ID" value="PSU_v2.g10866.t1"/>
        <property type="gene ID" value="PSU_v2.g10866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF330">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10866.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14226" checksum="EF794AF58FE4C20A" modified="2023-02-22" version="1">MGSIIGVIGPVGAGKSTLLLGILGETELDGSDSTSFLERGSIRIPQRCINEGFAYVGHECWLRRGSVKENILCGSPFQANLYNAVIRATALEHDIEKMPNKDEYQIGDDGTTLSGGQRARLALARALYQVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTV4</accession>
    <name>A0A914XTV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1040.t1">
        <property type="protein sequence ID" value="PSU_v2.g1040.t1"/>
        <property type="gene ID" value="PSU_v2.g1040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001857">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1040.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16702" checksum="102063EE1BF3B376" modified="2023-02-22" version="1">MSAKDKVHVNLVVVGHVDAGKSTTTGHIIYKCGGISKRQIEKFEKESAELGKGAFKYAWVMDKLKAERDRGITIDIALWKFQTDKYYFTIIDAPGHKDFIKNMITGTSQADVAILVIDGSNYEAGISEDGSTREHALLTHTLGGEVQRDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUI7</accession>
    <name>A0A914XUI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUI7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10198.t1">
        <property type="protein sequence ID" value="PSU_v2.g10198.t1"/>
        <property type="gene ID" value="PSU_v2.g10198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10198.t1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25222" checksum="D812E317828E3287" modified="2023-02-22" version="1">MAEKAGVKVGDTVEQIFGRKPSDLNDAQQKIQSSNEVSMNLKRFVANPPNMPWTLEDKNNQIVVNHFDKGGRMSGVSDHNTAGYQNSFQSSQALGGAPFAEEIRRTTTTKRTETREGPADQIAKFTSSNNENLPVSNTVKSESHSNWDQDEGNIKKHYETNRTYTRTESSNVTGGGGSGGAAQQQSIGAAPFNHGSNFSSSINANNWQSQQSGGGQEKFFMESKSKFSTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUQ5</accession>
    <name>A0A914XUQ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUQ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10699.t1">
        <property type="protein sequence ID" value="PSU_v2.g10699.t1"/>
        <property type="gene ID" value="PSU_v2.g10699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10699.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10588" checksum="DE69ADCF934DF483" modified="2023-02-22" version="1">MKPFYETKNGENLKLYYLEEESNGMPKIASNETNFQNIVLQLTTTTTSTVEPTVAPVQTAKPTMAPVQVVKKSDEISEASCLSLSILIPIIVVSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVS0</accession>
    <name>A0A914XVS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVS0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11071.t1">
        <property type="protein sequence ID" value="PSU_v2.g11071.t1"/>
        <property type="gene ID" value="PSU_v2.g11071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF165">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN FBXL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11071.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14809" checksum="5B2E72752F42BE35" modified="2023-02-22" version="1">MDLEDCNQITDTTLHNLNIGCPQLSSLSLSHCELLTDNGLSEFCGTHRDIIQILELDNCPLITDAAFEFMKPMKILERVDLYDCQNITKDAIKKFKQYRPDVEIQAYFAPITPPTAAQPSRQGICRCCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVW5</accession>
    <name>A0A914XVW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemotaxis protein CheD</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVW5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12073.t1">
        <property type="protein sequence ID" value="PSU_v2.g12073.t1"/>
        <property type="gene ID" value="PSU_v2.g12073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="CHEMORECEPTOR GLUTAMINE DEAMIDASE CHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147:SF2">
        <property type="entry name" value="CHEMORECEPTOR GLUTAMINE DEAMIDASE CHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="CNF1/YfiH-like putative cysteine hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12073.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12448" checksum="0E40142924B026C4" modified="2023-02-22" version="1">MNASLRTDDVMRYQDARFQTIAAKLLPTQYLVVDDTTALTTTLGSCVAACLRDPVLKIGGMNHFLLPEGNAGDGAPARYGSYAMELLINDMLKRGAHRKRIEAKVFRRCQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWE4</accession>
    <name>A0A914XWE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11287.t1">
        <property type="protein sequence ID" value="PSU_v2.g11287.t1"/>
        <property type="gene ID" value="PSU_v2.g11287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11287.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="9061" checksum="57D0D073825D9F40" modified="2023-02-22" version="1">MLERWTYEFCYNNQVDTSVLDKPSLLSTAEKYAKNGRELLEMFFETGGSFNFFEDVEIRSSKINYSNNSCLRGKNIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYD8</accession>
    <name>A0A914XYD8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYD8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11551.t1">
        <property type="protein sequence ID" value="PSU_v2.g11551.t1"/>
        <property type="gene ID" value="PSU_v2.g11551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="131"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11551.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33981" checksum="6FDF9F6DFB7AB886" modified="2023-02-22" version="1">MCQTFGGHIVTAESVAEFRHILSYFHVSFRNTWFGVWNDNLANGRWNSIDGSVVELVKYIRWCTKHPWMHIKGKRCIGLGYDGVSVCWFDQDCVNENNMQVVCKAPPIIDVQKSFSPTKYGCKLGWSYLPSTGYCYGANAGKTSSITWTNAENICQSSGGHLVTIESMAEFRHIMSYFHVSFRNTWLGVYSHSLAGGKYESIDGTVVEFAKYNRWCATHPWKQYGGKRCIGFGYDGISVCFFDQNCATDNNMQMLCKAKPILLEPIKEDPKAPIFEELEENPPIPTIPTIATTRKMSCYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ52</accession>
    <name>A0A914XZ52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1249.t1">
        <property type="protein sequence ID" value="PSU_v2.g1249.t1"/>
        <property type="gene ID" value="PSU_v2.g1249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1249.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11064" checksum="9E6E757F46E4B975" modified="2023-02-22" version="1">MFVGILAYIPGAEQCDGFKQAWIGLYSNDNSLSWQWTDGTPFDYNKWGVSQPDKPELQHCVQLFSSSNQCNWHVGDFNNFVCTIKLSSYICKKAPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0F2</accession>
    <name>A0A914Y0F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y0F2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13682.t1">
        <property type="protein sequence ID" value="PSU_v2.g13682.t1"/>
        <property type="gene ID" value="PSU_v2.g13682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036896192" evidence="6">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13682.t1"/>
        </source>
    </evidence>
    <sequence length="472" mass="53911" checksum="A55EF66C9A4A2FCD" modified="2023-02-22" version="1">MFFISVFGFILLIHESFGVCNLPPDFWCDHPKIAIECTGSLQYCDGYRAARAHQPINLRLSFESACPDSQQFITLRLYPQILSKPYLLNMVNFKGIPWGLAKREGESRVRCHHGERECIGNRLLSCAFLYYSNNPMKSGKLFNCFMSSMAYKPPPKRAITECLQHLQTPPEAQASILHCAQSSQADTLQRHDEVETRSVLSTPRFVPFISINGRSHIHMQAYQLFLGDKIPIWNRTLSTIAPTNSRASRCQLPPDFWCSDPSFTNECYNSAGCSAYERAAYGKPIKLKIIYDSSLKHSVDYILHYIKPHFSKDGRVTVEIEPTPISRCAASDPSCSDHAIQECVTNKINEPLERNKLFYCLLDAPSGGMKMAWAQKCHFLLKSFDPRLKDSVLNCANTNEWQNLASSRSQSHRIKLQPHPKQSDPWLIINDHSMQSAQAYQKILHQTICLWYRGPYHNRDACSRCEYEATHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y133</accession>
    <name>A0A914Y133_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y133"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1293.t1">
        <property type="protein sequence ID" value="PSU_v2.g1293.t1"/>
        <property type="gene ID" value="PSU_v2.g1293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1293.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24810" checksum="09DA5435F2F19F86" modified="2023-02-22" version="1">MSADSGDEEIQLSDETKKALAEFYADQQKAESSNEITENWQLSQFWYTDDTSIRLAKECIAACLQEAEENESRRIACVSCPSVMEKLLECEEVISGRIVPFLFEYDTRFAAKYGDSFSFFDYNNQDMIDPKLIASFHLVIADPPFLSDECQLKTAVFARRLLRQNGNTKLILCTGATMETMAEKAFNARRSVFKPEHRNNLANEFACYTSYKPVTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y274</accession>
    <name>A0A914Y274_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13335.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="7955" checksum="B1811FF920AE5616" modified="2023-02-22" version="1">MNIVEAISENAVVIVSSETGSGKTTQIPQFLYESGYTSKGHLIGITEPRRVAAISMSQRVGVELNDPSIVSYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2G9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13433.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22518" checksum="4348A416ACE1B196" modified="2023-02-22" version="1">MLEQIENLPVTLTNAVKTKVPVIEFFDNSSVICVWNKKRNCYEFAKKWNGVFGKDLFLSFENATPKLTDKFAKNRCSVVYDILQLLAAVPDENISIDSDWEFKVINNEKENDTVMVEYETHSAKKATSTPSHLMNLLLKEHFKVIKEETGGDLTEFGIYISGCCWFTSKARKILEKRFAEICENMKVKCEFIKFC</sequence>
</entry>
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    <accession>A0A914Y2L0</accession>
    <name>A0A914Y2L0_9BILA</name>
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        <submittedName>
            <fullName evidence="4">10TM putative phosphate transporter extracellular tail domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="WBParaSite" id="PSU_v2.g12024.t1">
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        <property type="gene ID" value="PSU_v2.g12024"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="2">
        <location>
            <begin position="145"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12024.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27812" checksum="60635680A8BFD79B" modified="2023-02-22" version="1">MRGRFYPRALLQLFVGIYLGELCLVALFVFKQNWAAIVLEVIWIVVTAAVHIYINWKFLPLFDIVPISAIKYAAGDATCNYPYHDHGSSEKEFVGKNYWEGENRFEISQYDQALINLPGEAAPQSADPEANTSQKLSPLNYLIRFFNPKKETFEAIRKIMPQTYFKYVEYNPRFLSTAYYDPAVSDEKPVIWIAKDPMGISEKEMNKTRQYGVDISNDNATINDKGDVIVTGSPPNYQLPPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3B2</accession>
    <name>A0A914Y3B2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="PSU_v2.g13938.t1"/>
        <property type="gene ID" value="PSU_v2.g13938"/>
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    </dbReference>
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        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13938.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9010" checksum="9FD3831E8104265A" modified="2023-02-22" version="1">MVNILEDVEFVVQKLVNNVVQGKIPKPIKPKRRPPRKNPNLSLDVRRSGRTSKEIPFEAMDSPVIGTFQQPTNSEPVTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3P1</accession>
    <name>A0A914Y3P1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SBNO family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A914Y3P1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1481.t1">
        <property type="protein sequence ID" value="PSU_v2.g1481.t1"/>
        <property type="gene ID" value="PSU_v2.g1481"/>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000342">
        <property type="entry name" value="Protein strawberry notch homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057332">
        <property type="entry name" value="SBNO_a/b_dom"/>
    </dbReference>
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        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF30">
        <property type="entry name" value="PROTEIN STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25373">
        <property type="entry name" value="SBNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Strawberry notch AAA" evidence="6">
        <location>
            <begin position="48"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Strawberry notch helicase C" evidence="5">
        <location>
            <begin position="745"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="SBNO alpha/beta" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1481.t1"/>
        </source>
    </evidence>
    <sequence length="1247" mass="140818" checksum="3F8746A2182BA684" modified="2023-02-22" version="1">MAQSLQGNSAIPPKQQPQENEEHDNGVQLSAASTFVECFPRKVRTGGPHPHTIVETAAMNAVEPPDVTINVSIPEAWIDNGALSCVQMEAIIYACQSHEQRLPNGWRKGFLIGDGAGVGKGRTIAGIIVHNYELKRKRSIWLSVSSDLRFDTQRDVEDVAGKDYCPIHHLSKFKYGNIRAQQKSTSKGIMFATYASLVGKSKAGESRLQQLIEWFGENYDGCIIFDECHRAKNLCPKSGTTGSSMIGKCVVDLQRALPNARIVYASATGATEPRNMAYMERLGLWGAGTVFHDFGAFLDIVNRRGMGAMELVAMDMKRRGLYIARQLSFFGVDFNVHEVPLTMDYKKVYDESVAFWTILQTQFTRAFELLAAQNKKSYKNAWTHFYSAAQRFFKHLCIAVKVPMCVEISKKALEQGKCVVIGLQATGESQTNEALGENEGELETFVSTPKQLLISLIEKYFPVDPDDDFDGKDPLKSLFRGIDSEERKWKRKHAHFDVDEMEKEAKRSKLIGDDESEEADEQDNKEESGESSEDNESEEEDSEEEEEEKDADMEEEEVDSGNEDDGYGEIDNSQNDLVAELMNELSTDSEADDIENSDTEGSPKNADSDEDERAIKLFCTDYSNMDHDPWAKRQRFVSETTFEKPIPISKNNNKKSTIKKIKKKPKEIKPKVEKISDYAKKITEEMKSADQECSNSESYDSGFNNELLTMDLSKIRPTDVSSTLLAIKEELLDRASKIGETLPINTLDALIDQLGGPECVAEMTGRRGRVVRDAEGVTSYKRRNDGENVNLDLINIQEKDYFMNGQKFIAIISEAASSGISLHADRRAINKRKRVHITMELPWSADKAVQQFGRTHRSNQEQPPEYLFLISELAGEKRFVSTASKRLQSLGALTHGDRRAVAESDDLSRFSIENKYGKQALQMLYKTFIDPKECPIRPKNLLADVQFFQEARGQMIRNGILKEINGLLNVDRENGLINKFLNRLLLMPVDIQNSIFDYYMSIFAYLVRRAKLEGTYDTGTLDLGSTSDHITRAETRIFGGRLTGTSFELLLHKIHIDRGMTWDDVKGTAALYSDGVFADSTTSQRNGRKNICFVYENPATEIPMIVIVRPNINRTQKPGTIETFLSNHQKYTDMEECKKMWDLQYKSTANQCLHKFNNATGSSCKQGGKCEVGQRIRSYFVCSGAVLTAWQAVEKTFEKFKRNHIQIVRIQTNENQKLVGLLVNPLIVEHLISELKNLYHAKLIRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4P9</accession>
    <name>A0A914Y4P9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4P9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13750.t1">
        <property type="protein sequence ID" value="PSU_v2.g13750.t1"/>
        <property type="gene ID" value="PSU_v2.g13750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="entry name" value="TonB-dependent receptor, beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="Beta-barrel_TonB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13750.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17825" checksum="AA87D5525BA8F537" modified="2023-02-22" version="1">MRRDSDQSNNGVYGNAYAGEKDRNVDALLQWKLSDAQELSLEAGHGVQQAFIDASLEKQDEGAWGASELKRSSLALNHDGTWSFGTSKLSAYWTEYKNDIGATGRSEATDTIIEGSLTTPFTLGVEHQFARLQPGSGYVGAVRRRRTEAAPHPGPDRGRAFGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4R3</accession>
    <name>A0A914Y4R3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4R3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13766.t1">
        <property type="protein sequence ID" value="PSU_v2.g13766.t1"/>
        <property type="gene ID" value="PSU_v2.g13766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13766.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20551" checksum="CF04C2FB32F8AE79" modified="2023-02-22" version="1">MKKAQRLREDLVSEKCRIGDLLSRLRTVCNAIRSNGGKLSNAEDLMNDDEKLIDIIDDVIMQALNAARREADALRLQQQLQIAELDDLKKDIESLRRAEGELNESDDKVKELIMENKNIKEQVTLLQERLRKLQVDDSAKASELQSIKRDMEEIHNKNVSFRFFNSNNFLFFAKNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Z9</accession>
    <name>A0A914Y4Z9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Z9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1431.t1">
        <property type="protein sequence ID" value="PSU_v2.g1431.t1"/>
        <property type="gene ID" value="PSU_v2.g1431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1431.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11171" checksum="F2C795604E8C0293" modified="2023-02-22" version="1">MVELSEVFPLMSDYIELKFPSKNSEKVVNYAPDENKYEPPSNLNIYNASKYLKISGIYMQSFKFFEEYKSDIKKLLECNPILKEKVKVEAANMWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5H1</accession>
    <name>A0A914Y5H1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5H1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1545.t1">
        <property type="protein sequence ID" value="PSU_v2.g1545.t1"/>
        <property type="gene ID" value="PSU_v2.g1545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1545.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="23979" checksum="199FBD8F9D74ACB6" modified="2023-02-22" version="1">MLSTPITKTIIPKKSPGSAVVSNSFMNALSAGSANAVELQKKRKKPPPVIDLPLNSPLEPVTVTTPGATVPPSTVPESDPNGPNPARVPIPGSKRRIHFADDKGEELVLIKYIENVLLNKTHRPSSDMKHADAEAERISMKQRKTDVEEEDDEDMQIEMQSSGNNDIADWQPIAYCDPDVKEFCSELVEEENIREGSAMRSFIPQPDGTTKHSCRFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y605</accession>
    <name>A0A914Y605_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y605"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14680.t1">
        <property type="protein sequence ID" value="PSU_v2.g14680.t1"/>
        <property type="gene ID" value="PSU_v2.g14680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14680.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14494" checksum="70EAD03B4F79D31B" modified="2023-02-22" version="1">MPKERHRSIFPWYSNGLPLIASAFELLSSLPSSSAEDIYYGRLSRDYQGRESRRQSGGGGNGNDRRQSGASGYFYGQQPLVHTFETSSSCTRRCALPCVVQNVEDLMMPRWICPSQIKAKLILMKTNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y763</accession>
    <name>A0A914Y763_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y763"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1347.t1">
        <property type="protein sequence ID" value="PSU_v2.g1347.t1"/>
        <property type="gene ID" value="PSU_v2.g1347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF5">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1347.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37558" checksum="35E839B2289F6192" modified="2023-02-22" version="1">MAFVVGVVNWPDGIGNYLGGRFTFREVLSDFISNCTMSEVNITRHGCSDDIIYRWTDDEDISESHRVLPTLFGYLFANFFLIAICISLAIPAGIFIPSFVIGACCGRIIGETMFLLFPQGIRGLAGTQIYPGLYSLVGASAFTGALTHSFSIAVIVCEASNWPKSGLLPMLVGLMAANAVSHFLSPSIYDSIIRLKNYPHLADLPRNHQIDIHAVTVEQIMVQDCVFITTKTTYKELRDLLIATPQLKSYPLVNNSTDRIMLGSVGRKYLYYMLTTQIGPDPSLLQRRASGNTSDLYSTYRKGSAINTNSVRFTDRHIQGNTLLSTSPLHEDHVSRKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8E2</accession>
    <name>A0A914Y8E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8E2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15543.t1">
        <property type="protein sequence ID" value="PSU_v2.g15543.t1"/>
        <property type="gene ID" value="PSU_v2.g15543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF194">
        <property type="entry name" value="CUTICLE COLLAGEN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15543.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="29170" checksum="A3339A0BBE1711E3" modified="2023-02-22" version="1">MSETKIIVGFASFCSTIAILACLIVIPSLYQTINEIHEEVQEGIQVFRIETDSAWTQLMDIQISVTPPSRPRENPFNSIFRQKRQDFSGLPAWCQCEPVKPKCPPGPPGPAGEPGTPGTPGEPGPRGEDNTSTYAPITCPPHDTSCVKCPAGPAGPPGPDGPAGPPGPDGQPGAPGIQGKNGQPGPEGPAGDAGAPGAPGVPGAPGDKGADGQRATPVPGPKGPNGAPGAAGAPGTAGNPGTDGAPGPQGPPGSAGNNGKPGPDGQPGAPGGPGLPGADAAYCPCPPRSAVFVHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8I6</accession>
    <name>A0A914Y8I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8I6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15760.t1">
        <property type="protein sequence ID" value="PSU_v2.g15760.t1"/>
        <property type="gene ID" value="PSU_v2.g15760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15760.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19846" checksum="2973CA1928610559" modified="2023-02-22" version="1">MFKSLLQRFVTFFGVLLRSTVKKRHADLPSEIEELNESVGKFEMLERDLTQVLPLVEKMEALLNETAEDLNEIEKVEKQKVLKEKEKETSRKKLEEARKKLDTAKNLLGDAKLLDKLIEDKIAAKDNVETARDNLFDFEVNGSWTLEQFEEAREDAQVCRYFIFVKTSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9T4</accession>
    <name>A0A914Y9T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Immunoglobulin I-set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g16971.t1">
        <property type="protein sequence ID" value="PSU_v2.g16971.t1"/>
        <property type="gene ID" value="PSU_v2.g16971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104:SF1">
        <property type="entry name" value="GENE 9195-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104">
        <property type="entry name" value="GENE 9195-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin I-set" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="688"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1505"/>
            <end position="1549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16971.t1"/>
        </source>
    </evidence>
    <sequence length="1610" mass="180908" checksum="96BDD4672012CB2E" modified="2023-02-22" version="1">MKLQEGMTFAQHEANTLKDAHDASIETASDKPTFSRSSSKQQKSSKKKMLERHASGISQGAGEYSEAESVQSAVDFALSQSNIIESGNESVTLDAEFSINRGVTDKDAEIFRRHQARQKAAIFKHLRQSSEESISTEEHAVSQNEARASRKGKTKKSTKESTEESISMSKELESGIYAEGAEQKLAEMAISEKVKKHITPEGEKSMIYEKVLAKPDTMQFVVEALKEKLEAADAKSLREPLTQNVSVEFIMDSDRESECSASSTQSSTADTLRAKKKMQESKESTTSVTENIITAPKTLHVETVHRRRSSERSEKTVLTSKEAFTENKQVDQEDAETQHKKSLKAKKVYSEATEETTTVTSVFKLQNKEAATESVRSSKSPKRAKTAKSLKMAVEEAEKIVGKDILKDSEGGSLTPPASPSKTPEVGLEAELGPSPEEESIEVFLSDEVNIGARKRIKQPMKEVDREVDITKLPENAKAKGAISLKETIQMSKSAKVPEPDEEKKAAAIAELKDTLDVSKQPRKKKAYKKSVSAESMHSEYVTASEGYGEEDIEDETFEATEAIKHSVGLRRGDTVEKAEETFSDEEAESIASTVEESKDEATTSDFEITSNKPKVPPKTAERKVKVATQKQMLSKTIIALPESDAELENAASKLAKDAEKVALDSPTIKDKILPLESDEDTSINPQLERMSEQADALANRTLEEREKALKDLHEAKQVTTSLDKTLSADNEAAEEAKSVFKKRPPVKIRKRIIQHEESIYDVEALAKPEEKYETVEVTLKMEIKLQEQKSLRSQSKERKQAAVEQHVEVEEEKKPVPKLAAKAKKLQKHRKKTRHPSSERESEAEVEPEPTTFNFPEERIEAMQTVADKLEEYGSVNAVLAVKQKYKEQNEAYIKEAEKESEDLFVGMRKIGDQGLAEVIIRDVYGTKLDVFKITKTKIQKLDEELEKRGIGKVVEMYIEQSPESDADDEMSLSSKIIPIDNREILKAKVDEMVGGTVTAGKKSKVAPPKENVIKPSFLQKKQRITAKKGQNLVVKLKLMSNPEPKMSIYRNEAYMEEDDRINIIVEKDKYLYTMILMIDSIDQTFEGEITFVATNEHGHDEAKVILNIEEVEQKVDLTKRVSYARGAPKFMAHTRVLDANEGEAFELIFTAKGEPTPVLTLDLDNEPVDLTKICVAENSHGHSYCRTTVRVMSKEERAAMAQKAKETEEEEKRAKSKSPSPSRGGKKKNIPKPLFIPDEIHSRFGDPSTFVSEANLTAKLAGEEASAIESIVSPVKNPLSASVERSFETVKITDAKDEVAVEAVISKPEVEEPKKKKTLKKRKSSIEQLQKPDDTAVPEDAKTTDEDSKRVEELQKRKDELEKRKQEELEKQKGSGDRKLSLAEAKKEAEQKKLEEAKKKADEEMKAKRKAAEEALQKKKEEEERKKKEAADAEAAKKTEIAAKKKEEQERKKAELEDKKRKELEAKKQAEEEARLKLEESLKQGKEAASKKERPSISDASDDEAKSLAEELKRKREEAAIRREEEEKRQREAEEKARLDEIERKRRAGELLDAEADELIRKAAAEFREKDRFAADEAERQRRQAELDAIEASKEELQRLLEEQHLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA28</accession>
    <name>A0A914YA28_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA28"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15615.t1">
        <property type="protein sequence ID" value="PSU_v2.g15615.t1"/>
        <property type="gene ID" value="PSU_v2.g15615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15615.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9131" checksum="FF3E8B0B0AD33A59" modified="2023-02-22" version="1">MKTMNDEFHKEKSKEWNDSKNVNNSTLSLHIAAYENSIEDTGESNCDEKGGPRNKSEKLTWIMGTSKQFLTGSASDIQVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAT7</accession>
    <name>A0A914YAT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAT7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17318.t1">
        <property type="protein sequence ID" value="PSU_v2.g17318.t1"/>
        <property type="gene ID" value="PSU_v2.g17318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17318.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32291" checksum="C5DDC7742376A809" modified="2023-02-22" version="1">MIENVNVFARVRPLSGEESCLQIELSRIKVNDKAYDLNYVFDESASQEDVFDIVGRPIIDGFIEGINGTIFAYGQTGSGKTYTMLGPDINGVEINKTTDGIIPRADPFFKFSMKCTFLEIYNDEIYDLLRNEDISLKKPAIRVCAGDVENVEEKKVTSYSECMELLKRGIKKRKNAETAMNRESSRSHAILMLSLVTTETNGVNIHHIRTSKLNLVDLGGSESHKHTNNSGIRQQEGSKINQSLSFLVKVIGQIIDRNPHVSFRDSKLTLLLRESLSGNAKTAILYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB88</accession>
    <name>A0A914YB88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB88"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16027.t1">
        <property type="protein sequence ID" value="PSU_v2.g16027.t1"/>
        <property type="gene ID" value="PSU_v2.g16027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16027.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15557" checksum="1C52361E350FE197" modified="2023-02-22" version="1">MSYEPAKTGGSAGWNDPPASAFLQGRPAGSVRPNMRPKAVPQQYYQQYNPVPQQQMSQYSEHQYQQHPRPHPSYQQHAGHQTYQQYPHPGQPCLVPPHQQTPAVGQQQQPLYPTTSQYSGGPHYPPQQYPPQGGPQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBZ3</accession>
    <name>A0A914YBZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1695.t1">
        <property type="protein sequence ID" value="PSU_v2.g1695.t1"/>
        <property type="gene ID" value="PSU_v2.g1695"/>
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    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1695.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22549" checksum="AA6BCA2E7AA4AD9F" modified="2023-02-22" version="1">MGEQIYTDQNGFQFVYNPINPTNLEDGRPMPVSKKRNTSSASSRYKADPLRSHQSNTFDTRLTEVDTDEENYLVPNSAEMVKLDPNGCKYTKVNVPVINDSSIIINPTTTNKTSEEEEGGEEEPQKHHYQNDGIGAAEIASSEYLNVDETTTEEDEIAMAPFGGDTVKQQQQQQNPSIGSTNDNNSSSFSKLGNAYINQAESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC78</accession>
    <name>A0A914YC78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YC78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17820.t1">
        <property type="protein sequence ID" value="PSU_v2.g17820.t1"/>
        <property type="gene ID" value="PSU_v2.g17820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17820.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16983" checksum="D0FFF14581E246F3" modified="2023-02-22" version="1">MKCRRQCQNHFNKDYDDDLHRGKSVYWVKVNKVTVGNMEMLKAALNITIESNEIIIKREIITNGPVLACFVVYEEFQHYKSGIYKAQTSSLSKDLYGHCAKLIGWGESETGMKYWQFMNTWGRSTWGENGFFRMADEPEEVAAGIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCE8</accession>
    <name>A0A914YCE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCE8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17096.t1">
        <property type="protein sequence ID" value="PSU_v2.g17096.t1"/>
        <property type="gene ID" value="PSU_v2.g17096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF15">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="320"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="497"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17096.t1"/>
        </source>
    </evidence>
    <sequence length="1106" mass="125486" checksum="09EA7A83E7FC709F" modified="2023-02-22" version="1">MYIYRIQIASIIKVLQKIVFQLLTLDAIRDLLDSYRALPQTLERAAVEKGSLTRINGRGVTPTTGRQYIAKTATDMGLLEVWATPRQSIVSDDDSEDELMNTDIEELRDAVESIQSLQRVLKLPNQHSNGSSPTNDSNPILHGSTSESSSMKGITTNLGGHPRGVMQFLPSAKNNQFQPTLDSYTWTKQQPTTIPQLLRRKASVPENYLQFSGSERSSPRPRPSMRIFRASETEPDLFASSNMGNNKGVDSIAGISRFSKLLNSLRSAKQDPEQWQYQPNFLMPPETNIAQRQLQQSLMQADQLLWKRRSRASLRRHQDIRNMAVRELFDTERTFVESLEYLVQKYMRPLKQPLECTLIDADLVDKIFYKIPEILAHHQVLYAALSSRLEFLQNDTVIGDVLLAHFTKQSMIETFMAFVDNFKHAKQAIWDARQRPAFEKYYMRCSREHRNKLDLDSLLILPIQRVPRYELILKQIVKHTSVEHCDYEKLILVQDHVHQLAVAINCQREEKEKMEQRLREIEAIVDGLDDLVSPGRTFNRYDVVTVRDTKNEKKQRCIFMMSDQMIVTSIYRRPLITRGSGRGQTYSQSPDFLDNNRFKLLIKISLYDVEIGQDTIPLLQNAEQQLRNAQEDVNIVSKIMDLTKLLKSEHNKLSEHLDEMYTQRVTHLKALQDQMTSNPDLTTVNLQVTTFEGIETFTIQFPNAEKRALWENGFLEAKNVLRNTLHNEQSPPLLKSILVHRARQGLTFNVAMPAIIKGTEGAPNVWLCSSDKFSGQIAILSAVGDPTVESTTNLGNSALKAICAVPATGRRRTRSKITETIKSDKSEIELDSSSSDLDYSDSESVSPAQSTMWIGNEDGEIFIFNYLDNVRLKAREKAVRLPLPIVDITYVEERVFVSLSSKSQNQLVYFTRSKGTKTSALTSDTSEIITIMASLGSIIFVAFEKQTNVKLLNAFTLDCLSEFSITPVINKTLSTKEDIIRNHKLGSLRITTMLCARNQLWVGTSAGILLTTPVNRNKSNWVPNFNVCSIGHIGPCRFLTSVNISPLASAINLNKRRMSLNAPSLQQYDQIYVISGGNGVENYSMSNNNEETGVDDACNHLVFWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCR5</accession>
    <name>A0A914YCR5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydroxy-acid dehydratase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCR5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18031.t1">
        <property type="protein sequence ID" value="PSU_v2.g18031.t1"/>
        <property type="gene ID" value="PSU_v2.g18031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43661">
        <property type="entry name" value="D-XYLONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43661:SF3">
        <property type="entry name" value="D-XYLONATE DEHYDRATASE YAGF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18031.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16699" checksum="F5630D5E8DC67212" modified="2023-02-22" version="1">MPEYRSRTSTAGRNMAGARALWRATGMKDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEQVGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADAQLRQDHSRHADGRAAPQHPGGVRLRRADGSRQDQAVRAQAGPGRRDGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDQ9</accession>
    <name>A0A914YDQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDQ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17567.t1">
        <property type="protein sequence ID" value="PSU_v2.g17567.t1"/>
        <property type="gene ID" value="PSU_v2.g17567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17567.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33403" checksum="2DACA4CF27E62C5D" modified="2023-02-22" version="1">MVDEYLSDQFAYTFALENLCQSIENSFLEPLEHPHQIYLPENPLKDFCNDFYEIGFVIPQRIISNIKDFELIDFEDFENPEQIKSRLYGYVPKIYYQKHGIFTLTSLSTYFKNQYQKDNFDIRTLMDNGLKVVVSERKEQAGSWLINRIVAAANFVWNKVKAAATVVKNFAFSVVKTGFNLLGKAVSFAGSVVGKGAQLAGNFVAKIAKPLMDTKVGKYISDAVNDVKELGIDAAYVALGGVETVIKYAKKGANIAGEYAKKGLNAAIDFGKATTEWIPGMSILKNTAEKIGKEQWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDR2</accession>
    <name>A0A914YDR2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDR2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17437.t1">
        <property type="protein sequence ID" value="PSU_v2.g17437.t1"/>
        <property type="gene ID" value="PSU_v2.g17437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17437.t1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36564" checksum="609FD12F2286D3C4" modified="2023-02-22" version="1">MDGVAAGKSAALGALCRIVCEKSSFEELSADQLAQFYLIIHKALVERDRLTLCSILYYGNELFKLGLKGVEILLPNYLMAIDIILTESMKLRLHPSIQEIEMRHTCLQALSSIVSWPTTFSASAIIDESIGCKLGNGNTNLLEQRPTFLDLRQRLLRTLVHSLRNEADPTNLHLTLSSCAVFCHECSRHDLDVHSARKTSASSDAGLDSDEDKCFAVSALRAVVSAICDNIYKTQWTTELMIPLAALDCLNSLAALPNMILFSNDDMSTGSLIVTSLSRFIDVQLRKPPMYHSRDLHSSVVAAYSSLGQKQLNLGLPVAKIYLHLNINQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEC2</accession>
    <name>A0A914YEC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15753.t1">
        <property type="protein sequence ID" value="PSU_v2.g15753.t1"/>
        <property type="gene ID" value="PSU_v2.g15753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15753.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="23616" checksum="0851A5BF2F998FDE" modified="2023-02-22" version="1">MPTEVSSTNVPVKTESTVETAEKLTTISPIETTTLEKSTESVPIIVGIVGESSATPTVTTIASESNDETTASVTEEKTTVANLKATTNAETLQPITEINVETTILPVLQTTINAAENIIGAEVKEAIENANVTAKPDVETTTNLVQSEVKDAEKEIIVKVPKTISADIPSATISSESTITEKSVTDSPTTILQNVDETTTAGVTEVPIVLSTTESTSATSEAIKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGE2</accession>
    <name>A0A914YGE2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YGE2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18386.t1">
        <property type="protein sequence ID" value="PSU_v2.g18386.t1"/>
        <property type="gene ID" value="PSU_v2.g18386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18386.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="20419" checksum="A48CAA0DC291A61F" modified="2023-02-22" version="1">MNKGEISERAFDLTTECTRLNPANYSVWEYRRHLLRKLSKDLIEELDFCEESVQENLKNYQVWHHRREVITWIGEKKIDMEFINSILKDDPKNYHAWQHRVFLVRHFDVSLEAELRCTTEFISRDVFNNSAWTYRYCIVAEMSDNFENAKILDDEIKSVYSYLYQSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGZ1</accession>
    <name>A0A914YGZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone DnaJ C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGZ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18596.t1">
        <property type="protein sequence ID" value="PSU_v2.g18596.t1"/>
        <property type="gene ID" value="PSU_v2.g18596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18596.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16023" checksum="5B578F7C9C5AB4D8" modified="2023-02-22" version="1">MVIKQLDGRKLLLKKKEECGVLHSGLSFKINNEGMPIPNGKKKGSLFIKFELILPSSYFFKDESLYKQLEDALPPKENVEPLGEEVTLQEYDKSRYKNTNNSKHRNAYDSDEEEEDDDEDDVNGMKYEYEFRPGCPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHU1</accession>
    <name>A0A914YHU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHU1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18365.t1">
        <property type="protein sequence ID" value="PSU_v2.g18365.t1"/>
        <property type="gene ID" value="PSU_v2.g18365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="99"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18365.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20240" checksum="079CCFCC198D3067" modified="2023-02-22" version="1">MSKPTIDNSRNSPEAHVIQGRPFTFHCPVNGYPVPKISWLKDHKIVAVEKHSDLRLIDNGQGLEILSTQPIHKGLWTCQAENDAGDSEINVRLDVWTGPKASVRAGKDGVTRPLGTSVTLFCDTTGNPTPIVTWTFEDRVLLHSPNGTQISEGNKRLDIPVLKLEDSGNYTCKFFLVHKSTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ86</accession>
    <name>A0A914YJ86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJ86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17379.t1">
        <property type="protein sequence ID" value="PSU_v2.g17379.t1"/>
        <property type="gene ID" value="PSU_v2.g17379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036789140" evidence="3">
        <location>
            <begin position="21"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17379.t1"/>
        </source>
    </evidence>
    <sequence length="593" mass="67090" checksum="D3A3D256F0AAE32E" modified="2023-02-22" version="1">MFITSKSLIFLLFITVVINGRPTLNNLSSDPSNTAAKQVSDDVVELIGPGAPVELILLDGFLDVKIDLFNCLGLVKFCYSSLDENREAASLCRDNFCGFNVFGKFDEIELVRGKHILKSHLQQNCDAIRMNSIQTPYCGIYDASCKPFMDNENKITIIVESISCPTFIQRAKIYVPPTPSSSLSPSEPSSPDVADASTKWYIWIIMVGVILLFIGGIILGIVFCWKKQLCCFEQKKEIKKKITISETVNSTLITKDENILEANLPKSPPKPTQKTAEEIPPSPKAATKDTKKVEKKAKKVEEEKKEKKIPKKETVDDVPSSAPETQSAPPAPVFSNIPPRPIITQEQILEEDYSFRKPPKEWSKRIKNTSNSHSSKNSYGQVERNTPKMQMEPHYSCMRRQGLIMTQKYRELKKNYKVDAAKKPLDVEISLLTDCIGDIFVTINRLIEQSHAVLKERGAEFDENGKSKKYPPSVFEYLSDPETPEYMRFVAMAAEIEEIIPVDDIHLKQYSISLLLFIGFTKSFPDAKRRHALAIFRRKLPKIRAKSSVEERETFGYPANAIETAFKRDSRCFDDLKFIKTDSTVNLSEVTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL79</accession>
    <name>A0A914YL79_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914YL79"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18077.t1">
        <property type="protein sequence ID" value="PSU_v2.g18077.t1"/>
        <property type="gene ID" value="PSU_v2.g18077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000108">
        <property type="entry name" value="Ethanolamine-phosphate cytidylyltransferase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="202"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18077.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43669" checksum="F119340D6F4138C2" modified="2023-02-22" version="1">MAEEKIVRVWCDGCYDMVHFGHANQLRQAKQMGNKLIVGVHTDEEITKHKGPPVFNEQERYRMVRGIKWVDEVVEGAPYSTTVKTLDQYNCDFCVHGNDITLTADGIDTYAEVKKAGRYKECERTAGVSTTDLVGRMLLLTRSHHNLNDELDLVSRERTESLSTDSDSHSPWTRVSRFLPSTQTIMQFAEGRPPAPNDVIVYVCGSFDLFHIGHLSFLEEARKLGDYLIIGIYSDNIVNEYKGNNYPIMSLHERVLSVLSFKPASEVVIGAPYSITQELIDRFRINVVVQGNRVQHHPTIDDIDPYEVPKRLGIYKPVDSKNDETTEGIVDRIINHRRIFEKRNAKKEKKEIAAYKALQKLQQEKCSSHGSSGTTEVVCIEDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL93</accession>
    <name>A0A914YL93_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YL93"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19661.t1">
        <property type="protein sequence ID" value="PSU_v2.g19661.t1"/>
        <property type="gene ID" value="PSU_v2.g19661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="11">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="177"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19661.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="31554" checksum="1D2ABC939BABBC70" modified="2023-02-22" version="1">MQISVVLKKKDDLVFEETPIPTLQTPHDCLIEVKYTGICGSDVHYWTHGSIGKFILEAPMVLGHESAGIIVEIGTAVTSVKVGDRVAMEPGVPCRYCRYCIEGKYNLCLNMKFAATPPYNGTLTKYYVLPEDFCHKLPENVSLEEGAVVEPLSVAVHACRKAGIKPSTSVVVFGAGPVGLLCAAVAKAFGASKIINVDIQQSRLDFALKYAATNTFLPSKDGNAIENAKAIIEQNDLGDGADYIIEASGAPSSIFTGIHVARPNATYVQVGCGNDVVEFPIIQMGNWITSRSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLH6</accession>
    <name>A0A914YLH6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLH6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18177.t1">
        <property type="protein sequence ID" value="PSU_v2.g18177.t1"/>
        <property type="gene ID" value="PSU_v2.g18177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="355"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18177.t1"/>
        </source>
    </evidence>
    <sequence length="906" mass="102564" checksum="C646C83E1247846B" modified="2023-02-22" version="1">MARRALSNDPFQLKLSDSDEESDEGEIPQRPPRAVSSSEDGSSSDGSTAPEPRREPAEILEGREPTPPDDFNPDPVKKLVSLTEQELERFIGYARGTPTPDVTKRAAWMMELPAVDSFSATAPVIDSSLHSKNIKVSMSETQTASLQDGLFKILGLINIASSEAYKEPAKRDQMLVCASRLTSFLIHDLTVARRSAAVAALNLTPSHIAGIRSAKLEMINTEHPTIPDEDSHRLFGSNLKKTVKALLSEKEKEKKERKESRPRWVPFYLHSGISGMTLEKAPEFARICSKKIAGRLQDYAKNWKLITKDKKVLQYIKGYKLPLMAAPPRQLASRPQSAASKEALRQEVKQLLQKGAVRPISKTAAACISPLFTIPKKDGTLRPVIDLRGLNKCVRIDHFKMEGLLMLKDLISQGYYLAKLDMKDAYFSIPIAKEHQKFLAFEFEGRYYAFRALPFGLATAPFVYTKIVKQVLLFLRRKGILTVVYLDDWLIMGPTKEECKRSVSIVVEVIESLGLIVNEEKSHFEPVQTLEFLGLLVDTGTLEFKVPEKKQEKIKKMAMQLIKRQTPKAIEIAQLCGLLASIDLACNWARLRSRNLQRMLRGIGTDSIAFKQRLMITEIEEAELVFWASAEREIFSRAIRPPKVTFSFQSDASLEGWGVASKEERSGGRWNSQERKLHINVLELRAIYFGLRIFCHDMYKTGIRVESDNTTAIAFINRRGGTKSVRLLEQATELWKWLLERKLWLVATHIPGKNNVEADKNSRVFKEKHEWSLDRHIVKGLFQKWETPEIDLFASRLNRKCNKFFSLNPDPEATATDAFAQCWTGLYGYAFPPFNLIGRVLKKAIDEGAKLIIISPDWPSLPCWPELCRNAKDNPIFFEGKVTDSYSQICHPLSIGKSMKLVAWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM42</accession>
    <name>A0A914YM42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18390.t1">
        <property type="protein sequence ID" value="PSU_v2.g18390.t1"/>
        <property type="gene ID" value="PSU_v2.g18390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18390.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11594" checksum="7DEE7EF9EE54B8CC" modified="2023-02-22" version="1">MDALAHLLNETNNLELRQTFINHSVVVARTQEGTLVRKIDALEVFNIPDMEMLIGAFAWQHKCNEMIEGQLQPVLKWRFTVDEGKHTFRHYDFAVCFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMQ6</accession>
    <name>A0A914YMQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20869.t1">
        <property type="protein sequence ID" value="PSU_v2.g20869.t1"/>
        <property type="gene ID" value="PSU_v2.g20869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF27">
        <property type="entry name" value="AQUAPORIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20869.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13866" checksum="BF8E4160E1DA4F11" modified="2023-02-22" version="1">MLIGMAWGMNSGYSLNPARDFGPRIFTYFAGYGLKVISYRNYKWFLVPLISPFLGGPLGAWLYQFSVGFHIPSELDEIEEEFRRIQDNKMHQTVVLQDSETVTPQSSTHQHVHRFVKNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMU1</accession>
    <name>A0A914YMU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin-binding type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMU1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20707.t1">
        <property type="protein sequence ID" value="PSU_v2.g20707.t1"/>
        <property type="gene ID" value="PSU_v2.g20707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="2">
        <location>
            <begin position="79"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20707.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14426" checksum="14BC5A343E0F8AFF" modified="2023-02-22" version="1">MCGKSAPLINGYYPVCDPDDPGYSCCGAAGYCGSEDEFCACDTCIDYRAEPDKIIQEPIKPSRSIQWYLMDAPDGQRGRCGPTAPSLDGKPAICNPDDDSKHCCSNGGYCGSGDEFCKCEGCVNFRENPNHQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMV4</accession>
    <name>A0A914YMV4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2224.t1">
        <property type="protein sequence ID" value="PSU_v2.g2224.t1"/>
        <property type="gene ID" value="PSU_v2.g2224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2224.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11299" checksum="A3C4B415BDAA7129" modified="2023-02-22" version="1">MATECWKKAKLLGIIAISLYGLAFILGFNISSYLWLLFGFLVAFGVYSFVTVMTMACSFNDCVEAKNELSEEVKEALAYFEGVGFSRSIAENSNSSTHSSSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMZ0</accession>
    <name>A0A914YMZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20762.t1">
        <property type="protein sequence ID" value="PSU_v2.g20762.t1"/>
        <property type="gene ID" value="PSU_v2.g20762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20762.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43223" checksum="D9B9993A51C1885D" modified="2023-02-22" version="1">MNLSSSNPYYLALMNDIPINNSIVVCAGMSNTDLFISDGQYESFCLYDSSNLENNIPFGSGFNLNPMVSNSGCFHLYRWNSDDTTAVVFIRSRADQAKNCQDFKNVFQVGTQGTATSGTNGTCEMIFLATNYKEMSTILISDISTADTNLTIYGRETLTLRSPVNNKNIHDIQLQDAYLWKNFGIFYTFALSILVPSDATISVTTKTQNEPYTIQKKGCDIIQKGLVASPAYTGSNFNLTDIIYESEIDREHIVELNVLKMSDNDTVFLEYYDNDGNETVKVLENGFSFNFTANVETGFKLIINESFNDFLIQYTLTSNISPIYKTIYLSENMPYYLNVLENINVNDAIVICAANLDDFELFVTSGNHQDFWLHDSTNLENCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP50</accession>
    <name>A0A914YP50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21202.t1">
        <property type="protein sequence ID" value="PSU_v2.g21202.t1"/>
        <property type="gene ID" value="PSU_v2.g21202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21202.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16534" checksum="094A8D3497E00F1D" modified="2023-02-22" version="1">MILTPESLPLDPMLELHNELKNVLEENATVIILFGQEDKMCSKLLKTKLNYHTAGYFIIAHNNELSDIDTPNKVFDQYELYKNQIDGRKFYIGCRFGWYGERQLMEKQVDLDCIDADDLFWTYSDGINKFILPLQGLGINLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP71</accession>
    <name>A0A914YP71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP71"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2640.t1">
        <property type="protein sequence ID" value="PSU_v2.g2640.t1"/>
        <property type="gene ID" value="PSU_v2.g2640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25464:SF2">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25464">
        <property type="entry name" value="TRIPARTITE MOTIF-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2640.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20831" checksum="A95476FC7AD4BF88" modified="2023-02-22" version="1">MEVLPNIKYYQNVKILGNENQIGISVEALECKICFDLFDKIPGLLKCGHSFCYKCISLIRAQTVFKKLNAFQCPLCTKSLSLSDWIIPNYAFDDILQYASIFASQNKNIVFVNSDDQTKLLKKMKTQKHLYSEACKLLGSEKLRSQNKMTEVKKVENNLIFIIFTAIFLFILFALFKLAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPM7</accession>
    <name>A0A914YPM7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="4 14">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="4 14"/>
    <dbReference type="AlphaFoldDB" id="A0A914YPM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2141.t1">
        <property type="protein sequence ID" value="PSU_v2.g2141.t1"/>
        <property type="gene ID" value="PSU_v2.g2141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="672"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="42"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="338"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2141.t1"/>
        </source>
    </evidence>
    <sequence length="716" mass="82027" checksum="E32356E210348752" modified="2023-02-22" version="1">MVPPRCKGDDYITIVIDKKEHIVNLKQGNISSCGYGLAFQRWYWGNATRDMVATAMIGQPDGTFVIRDASTDGDFTLTLKVRGTDRLIKVICVNGKCGFNVESLEYDSVLHLMDAHRECPLTEYNPDLNVPLTFPLGRLICLGKKSSKLLIDDTYKRMYFALRCHMEGLQADYERIASQFDNLFWRKITLEQSIDARINKIYTCEEVTEIVAKNLQVMANKEQKCAAWVKDAYKRTMKRLNKHIKRYTAVKPLFDIDRGIFQAYLDLVDDALEAMENEVLHAYEVAQDWKQIIADHGGMNADEIEDIADDVGYLVSIEPIKMSDTLLEIALKWDPTCWMSIDSNKDHATNRIMSIADKMPDNSDGVFLIRPSASQDGFFVLSISMGGRVHNCLIEYRAQPPPGEYEAGFAFLETANYFPTLVDFVKFYSKFTLKEHNEMLDTTLKYPAFPGLNATDYVMKSWEAEYLRIWNIIRRDPRVRAGVICYISSIIFHCFCSSIFDLSTTIYYSFFCAAIFALLTGWRYYMFSLQSYFLGFVTFFSVYSVTHSLMDFPLCVNMYIMASFHYFEFFAIGISNPESLSQDSFLLNHSVAYWTAMFAGWGEYLLRNHFYPGTSAIIMFIGIMLCIAGEVFRKLAMWHAGTGFTHLVAFRKNKSHTLVTDGIYSICRHPAYLGFFLFSVGTQVLLSNYICSIAFAYYQKDVPIGLPFINGFTHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR03</accession>
    <name>A0A914YR03_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YR03"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2446.t1">
        <property type="protein sequence ID" value="PSU_v2.g2446.t1"/>
        <property type="gene ID" value="PSU_v2.g2446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.950:FF:000001">
        <property type="entry name" value="Methyl-accepting chemotaxis sensory transducer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004091">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt_Me-site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051310">
        <property type="entry name" value="MCP_chemotaxis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43531:SF16">
        <property type="entry name" value="METHYL-ACCEPTING CHEMOTAXIS PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43531">
        <property type="entry name" value="PROTEIN ICFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00538">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="57"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2446.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="25198" checksum="03D555A15A16FC15" modified="2023-02-22" version="1">MLLTPLAKIIAHIREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQALKRDQKPSLKTPSHALIPVRCWSKSAGETMNNNRQCCHSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS27</accession>
    <name>A0A914YS27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Osteopetrosis-associated transmembrane protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS27"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2458.t1">
        <property type="protein sequence ID" value="PSU_v2.g2458.t1"/>
        <property type="gene ID" value="PSU_v2.g2458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019172">
        <property type="entry name" value="Osteopetrosis-assoc_TM_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15644">
        <property type="entry name" value="OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15644:SF2">
        <property type="entry name" value="OSTEOPETROSIS-ASSOCIATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09777">
        <property type="entry name" value="OSTMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037068618" evidence="3">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2458.t1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34563" checksum="428C31ADE23C0F65" modified="2023-02-22" version="1">MFLYLIFLFSLLRPSLTIGETWDLDGPCQIHIQKFAEAQAKMVRCATNFSSPPKVCTNCIDEYIDFKQIEYDTHHLDNVTSLDNTTCTNVIYGNYLLSYSWEITNALTRSVWDKSRCSSCLDINWDFQNRNSTIQYDDKTVEFQSVLYAWRDCVTNYSSTIEGENTTTICAQCAKPYETLFLFYWKIYTDPTTDFCVDVETTMNDTMHVWHKVWQCPDDTKKDRESDVVMLLVSVAVLMVILTLFYGGSYVQTERAQRNLIRYSRLEAPRGQRSRLVSSSSFFSSPGASAVSEEPTGRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSL3</accession>
    <name>A0A914YSL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GED domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSL3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20402.t1">
        <property type="protein sequence ID" value="PSU_v2.g20402.t1"/>
        <property type="gene ID" value="PSU_v2.g20402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="351"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20402.t1"/>
        </source>
    </evidence>
    <sequence length="442" mass="50642" checksum="DD0390C507577404" modified="2023-02-22" version="1">MNPGTNAMNELMGQTIPVRLGIIGVINRSQEEIAQNIDIETCLTKEQTFFRENYPSIASRNGFQYLRQRLNQLLIQHIAQNLPSLRDGINNMVIEHEAILEDLGEPVEEDQSKLAIEVIRKFAKLFENLIDGWNELDTTQLAGGARIGREFRNFSSFNSIAADGGLTEMVVITAMRNAHGTRVGLLAPGNALEQLTKRQTSRLREPSIKFVDVIKAILLEIIDYCTIKIKEEERNRFPLLYSRMNKIACGIVNARFQPTKEFVEKIVDMQLNYNNFKHPTFNEELDDETKQNIANCIISAPQRTNPFSDDENENDEIASSGASEGYGTQRNSPLQQNSLQDKILIDEVRDSIKLRYYIKQYYNIVRISLQDLLPKAIMTELVNHVKESMQRLLEEKIFALEDVQKLTKESEAITNRREETKEKLEDLEHAKELLQGIVEQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT61</accession>
    <name>A0A914YT61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SF4 helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g335.t1">
        <property type="protein sequence ID" value="PSU_v2.g335.t1"/>
        <property type="gene ID" value="PSU_v2.g335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="2">
        <location>
            <begin position="369"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g335.t1"/>
        </source>
    </evidence>
    <sequence length="635" mass="72844" checksum="BD8A0773B6C84D14" modified="2023-02-22" version="1">MDSGRFTSRSSAREERARKRRIKALFRADENDGNNSPGTSQIEDEEEEEVYRGIENSDDEEGDDDNDDLFMLPCLAERLSARGNNGVGSGAGIGGGMVENDDSGDSVIVPSNGGGRHSYHHQPPDPNIRLIWQDAIDLGEIRNVQDQSDFRSLRIQLGIDRIPSDTLSRYHLKGHMDSYEQPAICYPRYFGPSGRTRTPGGLKLIRRIGDKLEKENYPESENDYGKSRFSGIFGYHMVTPSDRRVIITTNERDALAVYAATGGLLCLALPNAEKLDHSVIPFLEDFETIHFWFPAIHEKYARDYASYLSGARCYIITKKERPIELIREERIKEIKRAIHEEAVRVRNPGFRCINDVREDVKNEIIQSKTKMAGFAQWKRFDVLNHYLKGFRPSELTVLTGGTGTGKTTFVCEYSLDLYAQGVRTLFCSFEMPEEKILKWMLVQLPLHRVENHPSVEMWLDRFERTKGDLIVMKTDEFRDKTVTEIANAIREQVIAGGIQHVVIDNLQFLVNLATLHNDKTSAIERYHQQDRFVGLLRSLATDYRIHITLVVHPRKVEGEEIDINHIGGSSRVIQEADNVLAIQRHRDEIDKRKFRKFLYILKNRYGMRRIESDQIEMVFAPSTYTHTLIDYAQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTR9</accession>
    <name>A0A914YTR9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTR9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3549.t1">
        <property type="protein sequence ID" value="PSU_v2.g3549.t1"/>
        <property type="gene ID" value="PSU_v2.g3549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3549.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14617" checksum="71F9FF2C03A56518" modified="2023-02-22" version="1">MKQAQAQARAQAKDGNKKENSAKKSGGAILHVNNYRNGVPEAKCKMSKNPNFPSSLKPGYIVRSKGSPAGPENSFVVEAKLAARVYMVRNQRTDKFCSLKIEPYYNEGDVKQLKRDVFILLEAMKLDRSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU25</accession>
    <name>A0A914YU25_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YU25"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20963.t1">
        <property type="protein sequence ID" value="PSU_v2.g20963.t1"/>
        <property type="gene ID" value="PSU_v2.g20963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20963.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12685" checksum="D103BBBE8A29EE4B" modified="2023-02-22" version="1">MPARPRVDRLKTIYTAARQLNFGFRLQGYPSAPNENGIFGFKPQLHRLTIRFCKQNDASMGIRNFIETSLKDFAAENPQTVVYVIPARNSVPTLRGEYANGREVHINAKGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU65</accession>
    <name>A0A914YU65_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YU65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g419.t1">
        <property type="protein sequence ID" value="PSU_v2.g419.t1"/>
        <property type="gene ID" value="PSU_v2.g419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g419.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="30368" checksum="1131768383C16EDB" modified="2023-02-22" version="1">MQFFRYLSRTLPKTIFRFQSTTASATNNIATAKEKDEDLIPESDPEKPIINLQPGGPLAEFFDAEENFGVSELRPKLRPGRPWTTEELRLKSNTDLHKLWYVLLKEKNMLLTMQHAYKIRHKMFPNPERLDRVHESMENLEEVVHERNDALLRLETGDSANPSERTVTSFAGFTYKKQAKEHYLPFEITGKKEYEVPYLDEEPYLTQKLWAEKQHLKKYHADDQRRYRERFADKDSYHHLRGSRKFFNRVEHLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUF6</accession>
    <name>A0A914YUF6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUF6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3771.t1">
        <property type="protein sequence ID" value="PSU_v2.g3771.t1"/>
        <property type="gene ID" value="PSU_v2.g3771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3771.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27251" checksum="49264CE80F6783BB" modified="2023-02-22" version="1">MTDIDVQPPVAVIGKHCTYNVYVQGNLEERHGKTVIVTVHDVGTNHKSFIRFVNHPAMADVKQKAIFLHVCIPGQEEHAPDFTGDFPTLAQIGEDLVCALDKFDIRTCIAFGEGAGANIICRFALASPNRIMGIILVHCTSTTAGIIEYCREKVINIQLENGVMTSGAWDYLAAHKFASSDKKEREAYLADLKNTLNPKNLSKYLFSFSKRTDFSTVIGAKLDNMDALLVTGARAPHIHTVYTTQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVJ3</accession>
    <name>A0A914YVJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bystin</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVJ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4153.t1">
        <property type="protein sequence ID" value="PSU_v2.g4153.t1"/>
        <property type="gene ID" value="PSU_v2.g4153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4153.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39891" checksum="6C4CA493F4C87DAD" modified="2023-02-22" version="1">MDSTSENAASRRSTRKRKSARKHSYSPQPPPYRKKVSDPPIDEASLMQKKEKTEDGLIRSQETNEVQQKKYKKTIKKEPETAGIESENEGDSGNYDTSSVSELEDSDELPPQLYSIISLQKGTQSGERDEYVDKSNEEIKPSTLKSQVNRHVQNSSVDTFVKVRDEASITKNKLTEKAKLCINLSIDPLAALKDLNPELFNSALKEPLREDDTLIVVIKLLENASTPSTSDTVVSFLQDAENLSRKFIKDLPLSLKKPRISLEKAWEAIAVTYGLFGPTVVPIILHFIKQQNILETKYFNRPAALFLYTLTIVKYFHEHLMPLLSPQISVTHSWILDTLEQPFLRSYLTMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVU5</accession>
    <name>A0A914YVU5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVU5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4105.t1">
        <property type="protein sequence ID" value="PSU_v2.g4105.t1"/>
        <property type="gene ID" value="PSU_v2.g4105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4105.t1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22811" checksum="E94B457233FF1374" modified="2023-02-22" version="1">MNADQSSPISQEKIRRIELLTFDKEQKVYYAGYCNIFINNALKVILVQPENEGKNFKPISASFSWTFIQVKQLLWVLSDGVIDNFALVFENETDCKNIMEIIHNSEIPNESSSNIISESQKELYEEKCILALLDQFYNPNIAAIVYHLIKYFNENEKQKLINLLKSENLYETLYGLIFEEKKLKNGKVKAVNNSTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVZ0</accession>
    <name>A0A914YVZ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4147.t1">
        <property type="protein sequence ID" value="PSU_v2.g4147.t1"/>
        <property type="gene ID" value="PSU_v2.g4147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="315"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4147.t1"/>
        </source>
    </evidence>
    <sequence length="678" mass="77357" checksum="36411268CC6AA8E1" modified="2023-02-22" version="1">MQEKNYIHDQPHRITGTLPKYNSFIHGESRNGRNNRQNMAAQPLKPLGHGSKSLSEKNHDAFKLFEDGVGLTLNERNELEIIKNNFKRANQQNFSTFVQDAFKRADFIYEKGNKIISLYSLLEKELEKAQSVTEFSRIIIFTNSLSEICDVEYVLGKVSQNIPYLSFSSASSELIDDAAEMLLAGQIKVLILTGIYVTGNHNIYCDLVINFSLPSDVENFVLLLQNIKMYSKCITLVTTKFDFDLIRNFAELFKITDSDVPQSIIDVLYGKQNHALSDATNQLSINDTLVNLFDNVEHEYKVLRPYEKYYECATYLKNLLNGSNDIPRVIIITDSYNEIDRLLQRLQNQNIPFVTINDYTKDDEITSNLHKFYGGYFLISKDTHISGRDISCDIVINFSLSDSVEKYAKRLRNIKHKKCLTYIDGYNNRFLLRNISNILKSSNSEVPESLKNVLCWSNCGTVKIDDVFADTQIDGDKDEDEQAMLMASKCKKIEVISDMKKPQMCYNYILDCYRKVLDVPAMPKSLIFVNTAEEAKEVYKVIEGCGYPCRYLPENTSAEMIKEACNIPVLIVHDNICETVKNLYFKMIIHCSLPADIGTFINRLKTIKHESSYIYACVGRDTAIMNKIVEIVGASKYLKHDEDNSDETLKVETAETKSDENDGTVEDAGEISKTQALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW19</accession>
    <name>A0A914YW19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4760.t1">
        <property type="protein sequence ID" value="PSU_v2.g4760.t1"/>
        <property type="gene ID" value="PSU_v2.g4760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="2">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4760.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19333" checksum="D42801D8DB2AE8A1" modified="2023-02-22" version="1">MFKRLSGPATNLWKPKNFYSIEYLKYLHGVLYKNKVVNDNNKDLIIEALRLLAEVLVWGDQNETAIFDFFLERQMHQHFISIMQQKCDVLVHIQLLQTLNIIFENLKNESALYFLLSNNNVNTVIQHTFYFANEDIMAYFISFLKTLSLKLNSKTVHFFFNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW48</accession>
    <name>A0A914YW48_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW48"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4203.t1">
        <property type="protein sequence ID" value="PSU_v2.g4203.t1"/>
        <property type="gene ID" value="PSU_v2.g4203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4203.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40918" checksum="CD944F47069B1924" modified="2023-02-22" version="1">MMSSSASTSSTSYYNTSKEDEEFAKPLITKSFFGIKYSNPPSFTTWKGLPSFISLIRWFFFEKDESHLPSKEFVAKALPVITPKFDLKSKLSATWLGHATVFVQLEGLNIITDPVFSSRASPLFTMFFAGPKRYVKPPCPYEDLPPIHVGVISHNHYDHLDAAAVIKISALNPKIKWFVPLGVKKLMDSIVPDAEVIEKNWGEIEELQMNGILYKVLCTPAQHWSQRGFFDHNRSLWAGWAVMGPNYKFFYTGDTGFCEEEYKKLGKKYGPFQLAAIPIGCYCPRWIMQSQHINTEEAVLIHKHVKAENTIGIHWGTYLMGSNEPYLEPPKLFGEAAAKHGYTPKNLFTVRHGESWSYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW86</accession>
    <name>A0A914YW86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4826.t1">
        <property type="protein sequence ID" value="PSU_v2.g4826.t1"/>
        <property type="gene ID" value="PSU_v2.g4826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4826.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20674" checksum="71964B059D2543E9" modified="2023-02-22" version="1">MEVDRVILTPKKSYTLKTIKTEPVSPKINFNDSIISATVGATPVTTDNEADNELSFIETRENAKFSGFKTCVLDGAKCVVLKNRYTADPSQLMTVETNGKQTIMHKTDFTPKKKDNLRFKVTENPDDKTSVTVELQKVISPKKIKTLSKYVVKKPVAKKNSELNSSDSSFIISPKKKVVIQKECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWJ5</accession>
    <name>A0A914YWJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DOCKER domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWJ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4341.t1">
        <property type="protein sequence ID" value="PSU_v2.g4341.t1"/>
        <property type="gene ID" value="PSU_v2.g4341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF26">
        <property type="entry name" value="ZIZIMIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4341.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22275" checksum="E7FF940F73888BD8" modified="2023-02-22" version="1">MNINQIFAYLSVEGPFPSKTRRQKVVVRNEIVLNPLELACDSLRQKALQIRRILAAAGIAPRCAFVGVEAAAIARLDFKGLQLFLQGAVSPTVNVGVLAYAEAFTSPSQKERYGQNGIDKLVTSFKILMTELQDALEVNAKAIRSDQHEYQEMLQKSFIGMLERLKDFFGDQEFINRSDSSMDNTYDAAYVLNSIGGFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWN5</accession>
    <name>A0A914YWN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PD-(D/E)XK endonuclease-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4065.t1">
        <property type="protein sequence ID" value="PSU_v2.g4065.t1"/>
        <property type="gene ID" value="PSU_v2.g4065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008297">
        <property type="term" value="F:single-stranded DNA exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340:SF3">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK endonuclease-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4065.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33235" checksum="821F032EFE7A8AD4" modified="2023-02-22" version="1">MVKRTTSGTNFHKTVEFLLSELQKNGNMSDESCDKALNEKALAENHGYIASILPVLKKIPKTDWMKLEKATKNHYYCFQGRFDAIVEIEGEPTLVDWKTVSADSYKHNTTSKVNDLQRLYGVPLQVAAYIASVNTDPDYKTMPKIRQGAVVLAYESVIEDKEPIIKPADVVIIRPDDLKEYYKILAEKLNSFWWKMMHPKKGDKDINGNINFVFNPALRPPASKKLDKKADVIVLEDEVIIDSPTTASEDQKLQEKEEPPKAAKYYAIFDSKNNKKVASGKEDDKSSNKAAFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX58</accession>
    <name>A0A914YX58_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YX58"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4231.t1">
        <property type="protein sequence ID" value="PSU_v2.g4231.t1"/>
        <property type="gene ID" value="PSU_v2.g4231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395:SF23">
        <property type="entry name" value="GEO05642P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395">
        <property type="entry name" value="SHISA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037250081" evidence="7">
        <location>
            <begin position="18"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4231.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="42090" checksum="11712ED21F914063" modified="2023-02-22" version="1">MNFYFLMAWIPIVINYANEITSNDDQVPSIMSISQFVLTLTFDTPITDERKLYSDLQIIADNVQYNMTLGSMILNGSKTFTFSEDSQIDETILNPFETIIINSLFVFEYYRLQNVDVVIQPLVSITPYNYSADTWISVTQSGENILPHILWNVTFQYKKSCQNQNYGFHCNNQIDSTSTSATATSTTSSSLTYTDFSSTSPISDCLQQIHDLESQKNDEKRLKNLFLWLMIGLFVLSVILLILMILFCCCWLRNRGRVAQYAEEHSNQRRVRRDRVDIVHPHVYPEDQRVEHNVTVRQRTLPPYRPPQPQQHQQQQKSNQGPIDASSNVVFPRTQHSRQQPSRPFQYPSDDDDWSIPPNEHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXL8</accession>
    <name>A0A914YXL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTP synthase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXL8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4705.t1">
        <property type="protein sequence ID" value="PSU_v2.g4705.t1"/>
        <property type="gene ID" value="PSU_v2.g4705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4705.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17483" checksum="142C36E52DA824A8" modified="2023-02-22" version="1">MKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTNRLSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYC1</accession>
    <name>A0A914YYC1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA (guanine-9-)-methyltransferase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYC1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3059.t1">
        <property type="protein sequence ID" value="PSU_v2.g3059.t1"/>
        <property type="gene ID" value="PSU_v2.g3059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18102">
        <property type="entry name" value="Trm10_MRRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025812">
        <property type="entry name" value="Trm10_C_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF5">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3059.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29610" checksum="D52426DFB11438B5" modified="2023-02-22" version="1">MENQKEDMRLFQSISLKETPHLVVDCRYIPYLSERAQNLTSIQLGYMISANRRLQTPWPLYFVNFDLKNNILKECKRKHLGVLDNDRKICAFTSEKNYTEIFDPKKLIYLSPDADEPLKNIELDKTYIIGGIVDRVVEKDIPRYASLEMSQVDGIQSYRLPINENIQWQSGTQFLTLVTVMKILQNTFENNGNWKETMQKLIPTRHVKPLEDRRDLPKQLQHNHAQYDMEVLRILEENLGKDFDRKISKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYU2</accession>
    <name>A0A914YYU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase-oxidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYU2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5278.t1">
        <property type="protein sequence ID" value="PSU_v2.g5278.t1"/>
        <property type="gene ID" value="PSU_v2.g5278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000002">
        <property type="entry name" value="Nif3-like dinuclear metal center protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF14">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1 TYPE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5278.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12276" checksum="0DAF0A0920934107" modified="2023-02-22" version="1">MPVPGLELASWIEARLGRKPLWCGDTGPEVVQRVAWCTGGGQSFIDSAARFGVDAFITGEVSEQTIHSAREQGLHFYAAGHHATERGGIRALSEWLNENTDLDVTFIDIPNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZT7</accession>
    <name>A0A914YZT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZT7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3546.t1">
        <property type="protein sequence ID" value="PSU_v2.g3546.t1"/>
        <property type="gene ID" value="PSU_v2.g3546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3546.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9505" checksum="12CD545DEA3A1056" modified="2023-02-22" version="1">MGVYLSGQRELRRSSLPFDRVYESSNDMAFNVAYKVKEILTSFLSADEKIHVTITNAVPSEGIDFIDRFYEFSDNGKAIFSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0F2</accession>
    <name>A0A914Z0F2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0F2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g583.t1">
        <property type="protein sequence ID" value="PSU_v2.g583.t1"/>
        <property type="gene ID" value="PSU_v2.g583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g583.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8044" checksum="3B8A2AEDBBE7CBA7" modified="2023-02-22" version="1">MHESMKLLGRLTSTTNNSEPFYRALSPRFMPLMPLNEGKRQPETYLSPTIMAMYDEPNKTNEISIGNVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0N5</accession>
    <name>A0A914Z0N5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">USP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0N5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5917.t1">
        <property type="protein sequence ID" value="PSU_v2.g5917.t1"/>
        <property type="gene ID" value="PSU_v2.g5917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5917.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46270" checksum="89F40034D5095EA5" modified="2023-02-22" version="1">MNCLLQFFLHNRIIIQWLIFHKCNYSGDIPGCLLCELQKLLKKFYDPLRTCIPAPSDIFTVMLNRRPEFLATAHLQHDVQEVFSWLIQDISSQEDRHSQTFSKLFYGNIQSLLKCENCNKKQIHYESCFNFFLPYPDSNASMIDCLAEFLEDVSCSVVCKSCNQKCSKIFPSKFISLPQIFVLAISPFNTSKKRVVKTTTKIAIEKEIDISAFISTAIDDEFPSTSKEAAAEEIFSLKSLKRRRGDVDRDDEYLYAEEKSIKRLFIPSSDMMIDAARATTLTPDSDGDSGLGNENCSPPSLEPSDLQPTTPHHHRSHKNKQKIAAIKNTKYKLEGIIYHRGDEKGGHYYAKVINHMSSSTTIKEEDEWIECNDTKVSHTSINDSQCDDQPYLFFYCLNNNNNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0W4</accession>
    <name>A0A914Z0W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0W4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5526.t1">
        <property type="protein sequence ID" value="PSU_v2.g5526.t1"/>
        <property type="gene ID" value="PSU_v2.g5526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5526.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15362" checksum="99D1B57B41035F9E" modified="2023-02-22" version="1">MVGQERGSENTFSVLLDDMIELGHDYTFTDCNIRDSAAPAPSTSYASNSADPPSSTERGTPTTPPRATFARPPATPTTPTTSRPTFERYRETPTTLTSAPSTPTHASDGRTAVFIPVSFDSVSSPTALPMSANNTPTSSHLLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z147</accession>
    <name>A0A914Z147_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z147"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3996.t1">
        <property type="protein sequence ID" value="PSU_v2.g3996.t1"/>
        <property type="gene ID" value="PSU_v2.g3996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3996.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10323" checksum="56AF4AE1EB2CD2B5" modified="2023-02-22" version="1">MSTPAPIVLNSGTNVKGFLIKRKLGEGACGTVYLVHSIKNDKIRGAMKVEPQMKSKEDEILKMEVFVLRKIQSSNHACRLMASGKHTGFSFVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1C3</accession>
    <name>A0A914Z1C3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1C3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5689.t1">
        <property type="protein sequence ID" value="PSU_v2.g5689.t1"/>
        <property type="gene ID" value="PSU_v2.g5689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF16">
        <property type="entry name" value="HELICASE WITH ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="307"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5689.t1"/>
        </source>
    </evidence>
    <sequence length="507" mass="58267" checksum="B714B2EB0A823E7E" modified="2023-02-22" version="1">MKMENEYYLDFLLNEKSARSTIMEAFMPDSESNERIYQIPNKDREARKDKKIKAGDSTFAQFIARNEINAGKPIVIIDGPPQTGKTDLLSYIVPDILKSLITSSSSDSDKCFALVSPAYTLRNLVIKIKQHSKYQQICHKIKILDLTVWPADECGSFLSVIQVTLKRSIGDYDAQEKLRKAHTAFCSKVQPQNLEIYDSFDSTDTDLITSKELKVFQDAIKVIFAYYHPNFVIASNETFISLLPSMANYISHIAIDEAGKASYLDCFAMVLEAPHLQQLILIGDTNQYPTHRRIKQSQLPDCFKNVMFEVNWKSPALTYIQLNKTFYMNPGTVEIINKLFCPERILTPLYPTTLTKSPLIRNPELGIAFYDTDGWDAHVKPTSRKNFGHHFQALQIIYQLLDLYPGQKITVLCYYVAQKLMMEKTLRCEMIDQRVEVSTVDGYFGKNSDICIIITTRTLDAVKFLRHYTRLVKHSRVFFRKLPMQHNIELGKDVGEFLSFLTVIIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z289</accession>
    <name>A0A914Z289_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FANCI helical domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z289"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6012.t1">
        <property type="protein sequence ID" value="PSU_v2.g6012.t1"/>
        <property type="gene ID" value="PSU_v2.g6012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
        <property type="entry name" value="FANCI_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6012.t1"/>
        </source>
    </evidence>
    <sequence length="929" mass="104812" checksum="11B65A431BAC728B" modified="2023-02-22" version="1">MSALMPVVIQRDGLRKKIFESLKVQMISVSKVSTALPIMFQLLRSLTEQPENKRAFQCSQSFASFSSQLSGSQQEASSNMLEAIPIIECIKRCMHQSAATKCLVYKGIVDLCKKNNYFVLHGLDLLLVELTSLPKLNVGEYTVKIDRVYYLKFPCPHLLKATLAILSAATIGCENTVQFCQSQLSQNGADTVVKAEVAVEKYIEYILSVHLEDLQLDNNNSQLSNPTTGSDTMRYKTFGSMIIQLYDVIIERLWVFLNSDEHGDETLEKIQTLILRRKSLSELLETKPKSDKDASAKKSPKAKNGKKMDAKKESVENLKLIVQDLQIDIPKLSKMLKDLDLPALDVQAANNGSTVKDIFMSWLIPRIHDSVSLLDPKSSTCLASKISLTSMACSLLKFFSSSLTSSASADAKPFVIAQTKAIEAYSKIIIYILSKYEGKCAETLKEIFEKVIFSEYDAGTDCRQYSQVGRRVAEVAEMEIDQREDDNINAAGFDSDFRVYSAKHIAAYYQKILPGIFSTRSLFEKRKTLAEYCKQICSFIAVASKLSSMLTSSSDEIRKNVIRLILEIAEKYEIGDKNATNEFWKAALDIIAHSNCDDYWMELFDKLINDMIKITSRDNSDYVIYKSLNTDTAPQFYVTIVRTVSRLLAKVRTAVNVKTEIGDEITDEFLEIICCTVEIFAAKILKIIKIDDSIVTENEQMVTAAVEMLTDFYSTMNSIAQQFKAAKGDKVKSWESLYVFDRVLGDFVDKIIKESANKFGRSKYTGLKSSKSTKESAAKKAKTDEERQQAESVRRNKKDERLFVRLDKEFETFHGALIMIEEKYGCEALLLNLPSAKDKAMRVFKIDEKALARVFGGKRKIIESGEEDNNDKSDVESEKDEDKNRNDKSDEEDKNDDEEEECNKSEEEGDKSDQDIIDSDDNAGSYDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2V7</accession>
    <name>A0A914Z2V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2V7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6215.t1">
        <property type="protein sequence ID" value="PSU_v2.g6215.t1"/>
        <property type="gene ID" value="PSU_v2.g6215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6215.t1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53421" checksum="4874328BE0E0B162" modified="2023-02-22" version="1">MANVLKLQKLKERCDGEAYDAIKRFNTDAGYQEALAKLKQRFGSDAQAIAALRKQLYVPVKDKTDLLAVRKSFDDFECCLSKLDEYNQDIDSIEFKLALLRKLPDIIISKLSDFEISLKREATVAEYCEHADLQISAHQKNFGNKFQQGFQKSNKKVEISKAVANTTRDPKVKRHQDPNLGDRKPQQHQQARVKYPPKCSFCEGQHRNDNCPVVTTVEEAKLIASDKRLCFTCFRSNHRTPDCRKEIECTHCHKPHHTLYCHSLRPDLRHNSRKDSKGSSPVVAAYKAVSSESDTEVLLFTREVLVSHPGNPSLAQKVLVFVDNGAQIPLIDYTLSASLKLPCANVSTTCQGADGNQFVASGKYKLNIHLEDGTTLPVYPYGAANLVQRISVPKVPVEKYLRATKGKFPLPIKLGLPLLLLSMREYALLFIDEDSKKLDNGFVLWQSKLGPFISGEGKVQRECIRSQSPLFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z334</accession>
    <name>A0A914Z334_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z334"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6463.t1">
        <property type="protein sequence ID" value="PSU_v2.g6463.t1"/>
        <property type="gene ID" value="PSU_v2.g6463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6463.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28531" checksum="E566A461FE111C62" modified="2023-02-22" version="1">MSGPIVDVTESNHELAKFSISNIDLSVANSLRRIFIAEVPTIAIDWVSIEVNSTVLHDEFIAHRVGLIPLRSSGVVDAMQYSRDCECSEFCPNCSVEFTLHIEQNEEGTLKVTSDDLVSSNPQVSPANGEDSPAITIVKIRKGQALKFKAYARKGFGKEHAKWNPTAGVAFEYDPDNALRHTIYAKPEDWPKSEYSELAKGQQADYDPFSKPNKFYFGVESAGPLAAKEIVLSGISILKDKLNNISSQLQVELLREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z362</accession>
    <name>A0A914Z362_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z362"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6795.t1">
        <property type="protein sequence ID" value="PSU_v2.g6795.t1"/>
        <property type="gene ID" value="PSU_v2.g6795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF22">
        <property type="entry name" value="TESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="226"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="291"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6795.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47602" checksum="8EF7AB3A086D35F0" modified="2023-02-22" version="1">MNHFYDLKDQLIKICTACFCKLDDHDIPKFDHKGCDIVICSLFGSKHHHNHFISENDSTLRHASRDWSTLDGSESNSSVQTALGPEIPFETVFRRDSSTTTATTSTGAENARSIAYSWEPPIILAKNNNTIMKEEQTQTIPSAIIVDVNKNEEAKRNFNQLISNAKEKHFGIAKAIQCNFPSIDLRQQQHQKLPSDSDNQQLQQQHVQHSIDVEEYQSRIKTTDKQSCEKCGDQLKSGEIGIVTPHGKDKEIFHQDCFRCSDCDKLLNDLLYFFKDSKYLCGRHFGDSHFPRCSACDELILTREYTEANGQAFHNDHFCCSRCDVPLGGMKYVQVENEQLCFECHNKYFSHRCNTCKKMIQPDETKLSHKGTFFHNKLDCFRCSTCNIPLVNRKFIFKHEKTFCSYECKTNFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3A7</accession>
    <name>A0A914Z3A7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3A7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6844.t1">
        <property type="protein sequence ID" value="PSU_v2.g6844.t1"/>
        <property type="gene ID" value="PSU_v2.g6844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6844.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23926" checksum="E4C8ECD5217B604E" modified="2023-02-22" version="1">MANVSSKFWITDTINIYDEIDVAPNRLSSIIPKVYQANITKLNLKNQIISYSDFLFLSSNVENIDMFCTTVKAGNDSIVPLEKLVNGLPKIKSLWFFDNSSASSITTTTFKKLLENPHFFKCAEIVMQNLPEKFDIETFFSYAKKNQTTKIFLHFNDSTSEAYKTRLETFIDLVVASQTHNYLPPLIHSPRIDDERWQKITSLYHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3M4</accession>
    <name>A0A914Z3M4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3M4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6493.t1">
        <property type="protein sequence ID" value="PSU_v2.g6493.t1"/>
        <property type="gene ID" value="PSU_v2.g6493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12164">
        <property type="entry name" value="GDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000110">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF012013">
        <property type="entry name" value="PRK15469.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="26"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6493.t1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26400" checksum="E54F9C8CDECF0169" modified="2023-02-22" version="1">MLNPSVPLFRLEDTGMGEQMQEYAVSQVLHWFRRFDDYRIQQNSSHWQPLPEYHREDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVLINLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFNREPLPPESPLWQHPRVTITPHVAAITRPAEAVEYISRTIAQLEKGEKVCGQVDRARGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4Z7</accession>
    <name>A0A914Z4Z7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATPase protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4Z7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g697.t1">
        <property type="protein sequence ID" value="PSU_v2.g697.t1"/>
        <property type="gene ID" value="PSU_v2.g697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000003">
        <property type="entry name" value="Atp synthase f complex subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="15">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g697.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="11718" checksum="3182061A212F57B5" modified="2023-02-22" version="1">MYCQRLAVPLTRALVARATLQAESALATRCLHTTVARKDIDSAAKYIGAGAATVGVAGSGAGIGNVFGALVIGYARNPGLKQQLFSYAILGFALSEAMGLFCLTMGFMILFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5N2</accession>
    <name>A0A914Z5N2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z5N2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7256.t1">
        <property type="protein sequence ID" value="PSU_v2.g7256.t1"/>
        <property type="gene ID" value="PSU_v2.g7256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000029">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="293"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7256.t1"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117782" checksum="168EFAABA6FA5D46" modified="2023-02-22" version="1">MTIDEFVVVVAAAALSRSKKHSTAATTTVAAFKGIGGNVSSGGVPLVDANIGDNVTNLQQQQKIRNHQNQNFATASTINIKETSKINNKTGYQTQKQVFKAAPVNNKLDTLTKASSTFNNNNFQKTGSGIIPATNIGIQNQFNTELFGKFFSPLLNLKQQQQKEVTSGIAQKAPSSSFQGVMPSIPNGAASSSSNSFNNNGRFVNGNSNNNNNGVIYGDIQKGRPGVSLDYEKILTQHLPVTNVQRSQNVNQNIKANNTQQKATTTARSRTTGDGEYQLVRHETLYSPYDNAYEVLEFLGKGTFGQVVKAWKKGSNQMVAIKILKKHPSYARQGQIEVSILSRLSNENAEKYNFVRAFECFQHKNHTCLVFEMLEQNLYDYLRQHKFQPLPLKNIRPILQQVLTALEKLKELELIHADLKPENIMLVDPKNQPFRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFKEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRFITTTQGYPSNAMLRYGVKTNRFFYKNGENYRLKTEAEVEKEGVCRPKETRKYIFSQLEDIMMVHVYCDGNPYNFISERDDRVAFVELLRQMLSIDQTFRMSPSIALNHHFVTMRHLDEISHTTEYFEESKNSMAVCNLTDRFCYRVMERGNKHVMQLDTGPLPPKMLPTGAPAFDEIKQEKVIPKETMQNIFKPFTSAQFMHSPVAQQTQIKQELSNNRKIIKPEPQTIPHQTVAPIPQNPIPAASIANYAPDLANRFLCALASQPKPEQYGYPPDVNNLFPSSGTKFVMPPTYLQQIIPFPVMHQPVVMGQTTLDHPIYGKISQPIGAALTQNRIDWPALIPAVQYPTDFTTQPQFNIQHTQSYQLAPQSLENQVQYVQAAAAPLWTTPLNNLAELYNTRPDVFSQANAFQISSNNSMQNVIHSTTVLPNSSNNSFQALNRTPSSSIITSAAAATTNSNSNLNGFSSLMATSKRKNSKCAIVRPLNEPRQENNNVIINKPSQISLQYPPPHTSDEKVIVSNQGLYNPPPFLPVWPMPVYPFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6Y1</accession>
    <name>A0A914Z6Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6Y1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8092.t1">
        <property type="protein sequence ID" value="PSU_v2.g8092.t1"/>
        <property type="gene ID" value="PSU_v2.g8092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8092.t1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30115" checksum="562E72B67C4999ED" modified="2023-02-22" version="1">MAYLENDDEERDLDKETVIPNDIVKTDITNENTTTSCSRNSSDVSQSDLPNEPMQASESESSISSSKKFLFNPDAPTFLPRMQPQPPSVPFVTFAQPQYITTQQFSQGYATHIPPHSLTNTLPPGYILTSQGVGMQHNPSMIQPTFIPQQIQYVPTGGVPMYNQQIVASSQGGGGYPSFIHQSQQPQTFVVRGNYDITNGGGYIQTNHHQPPQQLQYAAMPLQYQPPPQSLQQQHHHHHLPPPQQQQFQPQLPYSQQQPPNGLRRYGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7K7</accession>
    <name>A0A914Z7K7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7K7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6225.t1">
        <property type="protein sequence ID" value="PSU_v2.g6225.t1"/>
        <property type="gene ID" value="PSU_v2.g6225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6225.t1"/>
        </source>
    </evidence>
    <sequence length="777" mass="86886" checksum="C2B0332C9791F90F" modified="2023-02-22" version="1">MFSNKYYKFFNKPNNNEYLILDIQGAPPNFPATGVPQEFARQFTSQLANKKMTEEALNTVYQQFVQQQQNPQNPSSSMGISNQHNGISFVPPSDLGTRGNRTGRKNLKREMYYKKQTSSGADDDEYDGDSEQKSVQAKHVSEKFCSDEPLVCEWEDCNQTLLGLKNLVEHVVALHIQPQTTYCCKWSKCNRGRPFNAQYMLLLHVRRHTGERPHECFYPTCKKAYSRLENLKTHIRTHTGERPYQCEHAGCGKAFSNASDRAKHQSRTHSDVKPYVCITVHCDKSYTDPSSLRKHIKTQHGDKAYDLCKISKAQGAKDGKIYRLYIPSKSANPNEEMRLVTDEELREMGVVEANRLPKPIPIPADRAPIPTTVAQTPPISTTVTVTPSNGIQLPNVPSSNALLSKPVISGTGAFSPVSRTAFNHPNGTVTNTQGDEDVDPNMPVDVENCTPSGSPNHSSIGGRDENDSRGTSSSVNSNSNQSFVSFNTNRSSTSSASSSTTSKRPTFTVEQNMLALVQPLSNLNVKPTGLVRPRVRFAEPLNDIVKRPDPAFESITERTDENDDVVVVTIQNSPLTYHFDAESYATANEEEFSTVVTCVSFEEAKSFFEDLVRSTDYSSDMEEVDVVLHPSQAILIPNFENFEEHQNEIRHVLQSALDDGGKLIATYGEIFKSFKEYIESGKTISCTFFEEEFASSFAEPLLSDNISSHLLDFDDNESTNSLINNEIIATEFTQLQNYQASNEPVIEISNIPLSPEGEVTWLTESMQQINPSQWHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8G8</accession>
    <name>A0A914Z8G8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8G8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8199.t1">
        <property type="protein sequence ID" value="PSU_v2.g8199.t1"/>
        <property type="gene ID" value="PSU_v2.g8199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12384">
        <property type="entry name" value="RRM_RBM24_RBM38_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000077">
        <property type="entry name" value="RNA-binding motif protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8199.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="19804" checksum="3F8D75DF2C6D1EE2" modified="2023-02-22" version="1">MLPAIYGQLAAQNALSDPLLQAALAQNAAAVSAAQQQQQQQQQHSAAAVSAASSDTSPTGSRDTIHTKIFVGGLPYHTTDKTLHDYFIQFGDIEEAVVITDRQTQKSRGYGFVTMKERPDAEKATRDPNPIIDGRKANVNLAYLGAKPRNNVQLAGKLFFCGGGSVKFLLENLNLLETFRISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8Q5</accession>
    <name>A0A914Z8Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8Q5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6631.t1">
        <property type="protein sequence ID" value="PSU_v2.g6631.t1"/>
        <property type="gene ID" value="PSU_v2.g6631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6631.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21258" checksum="E6BD0515AE7ADA8E" modified="2023-02-22" version="1">MLAPIVTKDMKLFQTKPIPTRIKNVRSRAQSLQDFAKTTSTSQRIKIAPTQKRNAQSVGNLSLPNLSRSPPKLSNSRMPLAAIAEGIEVPSSSGGNLTNVPASEPNVHSPQKAVVKPRTVALDDLRVISQKNFVDPTQSLTNSENASAENSGTVSPSSTHGDKVSPSANKKSFINKLTSVFKSNKKNSIDDDGPTSPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z915</accession>
    <name>A0A914Z915_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z915"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6736.t1">
        <property type="protein sequence ID" value="PSU_v2.g6736.t1"/>
        <property type="gene ID" value="PSU_v2.g6736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037288322" evidence="1">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6736.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25346" checksum="2BA2E0E159151F18" modified="2023-02-22" version="1">MNPIILFIISLILIIFKVVAAADETCTTTDLQNIESCYQKYAPDGYQLFFQKRQSQFGTSQIINNWYNPCRSKKNLNKCLGNIVVQRCFNIANMSTLPFLNNSTDAAKVIISDFLKIDYVCQKIFNFTDNDAICLSEKLPKSIDKICKRNYSSCETINAFSSCIKKLAYKKCRKYVGCFVQKTAMLETCEFSSCGDCATINANKNPIENLCNDDKSNNTIFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z983</accession>
    <name>A0A914Z983_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-lyxose ketol-isomerase</fullName>
            <ecNumber evidence="8">5.3.1.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-lyxose = D-xylulose</text>
            <dbReference type="Rhea" id="RHEA:14201"/>
            <dbReference type="ChEBI" id="CHEBI:16789"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="EC" id="5.3.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-lyxose ketol-isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.15" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z983"/>
    <dbReference type="WBParaSite" id="PSU_v2.g848.t1">
        <property type="protein sequence ID" value="PSU_v2.g848.t1"/>
        <property type="gene ID" value="PSU_v2.g848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010864">
        <property type="entry name" value="D-lyxose_isomer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07385">
        <property type="entry name" value="Lyx_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g848.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13758" checksum="040E9D75C6B65FDB" modified="2023-02-22" version="1">MHRHVMKAEDIINRGGAKLVLEMFNSKPDGSIDEEGDVVVACDGRIKRLPAGGKLALAPGESVTLMPGNWHAFWGEGGDVLIGEVSTVNDDLTDNIFREPIGRFSDVEDDVTPVHLLVSDYDKWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9F0</accession>
    <name>A0A914Z9F0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z9F0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6876.t1">
        <property type="protein sequence ID" value="PSU_v2.g6876.t1"/>
        <property type="gene ID" value="PSU_v2.g6876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="30"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6876.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23009" checksum="802C17867A67BFC8" modified="2023-02-22" version="1">MLTNPGTVPKGTLDDHVKTLESQKGEVFLKCTKCSSVRPERAHHCSICDRCVRRMDHHCPWINNCVGEGNQKYFILFTFYICLVSFHTLYWTIWQFVQCINENWHNCSLFSPAATTILIIFLLFESMLFGIFTIVMFGTQVSSICWDQTGIESLRNERGKSQDKWKNLQVVFGGPFSIQWLNPFDRPFVSERAFEFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA31</accession>
    <name>A0A914ZA31_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">MIF4G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZA31"/>
    <dbReference type="WBParaSite" id="PSU_v2.g70.t1">
        <property type="protein sequence ID" value="PSU_v2.g70.t1"/>
        <property type="gene ID" value="PSU_v2.g70"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g71.t1">
        <property type="protein sequence ID" value="PSU_v2.g71.t1"/>
        <property type="gene ID" value="PSU_v2.g71"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="2">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g70.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g71.t1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19996" checksum="87078407FC85F32F" modified="2023-02-22" version="1">MMMEQQADKKDEQYQRMSWEKLKKKIHGQVNKVNVGNIVLVVRELLQENVIRGKGLLARSIIQAQTFSPSFSHVYAALVSIINSKFPNIGELIIRRLIIQFKRAFKNLNKATCVTVSTFLGHLANQRVVHELLILELLLVLMKDPTDDSIEIAVNLLKVCGQMLSQVTPQGTFGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBH1</accession>
    <name>A0A914ZBH1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZBH1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9273.t1">
        <property type="protein sequence ID" value="PSU_v2.g9273.t1"/>
        <property type="gene ID" value="PSU_v2.g9273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9273.t1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27260" checksum="4F9F4049A7A8CC41" modified="2023-02-22" version="1">MMEKIREIEQIKEEQFKEARDPKHWKLGKADFQKCIAEMTDGKVADYIPQLSRFDPNYWGVSICTVDGQRASWGDSKIPFCVQSVSKAFNYSIAASDLGADMVHQYVGQEPSGRLFNDICLDSNNKPHNPMVNSGAIIVSSLIKNTWNTADRFDHMLTEYRKIAGGEYVGFNNAVFLSERATADRNYALSYYMKENKCFPEETKNLSEALDFYFQLCSMEVTCETAAVMAATLGFYFKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD84</accession>
    <name>A0A914ZD84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZD84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9902.t1">
        <property type="protein sequence ID" value="PSU_v2.g9902.t1"/>
        <property type="gene ID" value="PSU_v2.g9902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9902.t1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48119" checksum="55AD6CA77256FF91" modified="2023-02-22" version="1">MVIKKGHTDIIVFIPQFRRETARSDCPITDQHILFELESEKKLIWTPARHIGGRRIVCHDDKYILKTAEEKDAIIVSNDEYRDLIKEQPSWRSMVEQRLLMYSFVDGKFMPPDDPLGRRGPTLNQFLSFSNPTVTTQLCPYAKKCTYGNKCKYYHPERKNGVRQSVTERLMSNNSYGGKVKQNLRERPSMIYETNISRNTRPTALQSPALCGSLNNRNVVGRTQSLNLNQSQQSFSPQQNAFKQQFQNYQNAITIEPQQMSNNINCSTLWNSHAALERNYSNPIQSSNYGQQMQNHYSSTMMMQQQQKQQFEPECVTSRSSSLSDFMFAAPENSGFYGSYTPSSGVWGESIFPSMQCKLQHQHQNQSAQDNSRLKLQYHLCQLFPEASVFAVMNSHPDEKDPQKLCQKIIALQKGFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDD6</accession>
    <name>A0A914ZDD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9684.t1">
        <property type="protein sequence ID" value="PSU_v2.g9684.t1"/>
        <property type="gene ID" value="PSU_v2.g9684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9684.t1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42311" checksum="97C76DA804B8BE02" modified="2023-02-22" version="1">MVLPLLFDHCVEEEKIRSLGCSYKQWSYSMLKPGHCPECHLRFKEPVALSCGHSICQVCCDALLEKCNRDTVAGKKESRRQTIRMGMSSFAHPISKRRKSVKLQKSLSIIQESDLSFPKSSTSERSIGYLSPQCPACLAPPRFQAPIKNFALEKLIEAWERYKSTKGRSSAQSRKLPSPAPSSTSSSGFDEAEDHYQNAVSDVPVVDFSIKKCNIAVLGAAGVGKSRIVRTQHLNNLFFGKIGSDNEINGDSSNSITELQAKYMIEILDNNDLDGDLEDADAIILAYSCNNHDSFVTAFKIFEQIKQRGMSHVPLILVATKCDIDAHRRTVKQEEAESLARHIGCQHMEISARKNIGVNEVFAEIVKQIENNSEETLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZFQ9</accession>
    <name>A0A914ZFQ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Origin recognition complex subunit 5 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZFQ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9112.t1">
        <property type="protein sequence ID" value="PSU_v2.g9112.t1"/>
        <property type="gene ID" value="PSU_v2.g9112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9112.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38949" checksum="302FFFE380CF656B" modified="2023-02-22" version="1">MNTENIFSTICTPSEVPSAVLKHFHIRCSDAHQQIEFIEKLSKHVKNENLGYIIGDGNCLLIDKSPKDLFSVITQAFDKKSSASYRSVADFIKHFHDILCKHLSSQLILCLRRAEYLQDIEAYPIIADLFRGFGDSMFKKRVKFITLSTLPWNMMLSNSSSLSPICIFIEYKPYGDKRDCVKAVMKLQEKKLSTYTVATDVDGKTPIKFCKEFAKQCCGSFEQKTTDPHKLLSLISRVATMCADKIDPSDKGYNINVVKQAIQRLDDDIFYFNVSDLLSDRKSKEEKHQESINSVPYYAKFILIASFCCSFNRKSTDLRFFDMVSFTVTVSLNNYSTFLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZG47</accession>
    <name>A0A914ZG47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZG47"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9256.t1">
        <property type="protein sequence ID" value="PSU_v2.g9256.t1"/>
        <property type="gene ID" value="PSU_v2.g9256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9256.t1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43674" checksum="C4F5A1918A442965" modified="2023-02-22" version="1">MAHGFSPSFSGDLKLVKSEDGYVNGIKFEAKPGAKAYRNHIRITAVLPDGRERCLTERKSKRDEKKDLPISAHELRVNNLILSDAYDHTHGFGVEGMERVYDNRAMMYTPVSIPCNTIEIPVEKLIHAKGYVTGQKVIVDIRNNDMGFLDLNDRKFFGVTTSTGQEDHELRSFYELLVVQGSLDLKECVAVGSELYISCDQRHQIMYTRGISFINGFKKNARIVQDNGKAVVKLVVDPVDSAFYAQQRLADSFHDVTNGDYSNPRAIEHFFSLYKNVRVFLSFNKSKILPVHGLSKQKLEDIRFDKDGIPTSVMEHFRNEYGFSSRAGEMPALEVRFMNGQHGFYPLDCLEILKCQKVPMFKYTLVSPTLHDDILKVKGFLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGB2</accession>
    <name>A0A914ZGB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylyl-sulfate kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9324.t1">
        <property type="protein sequence ID" value="PSU_v2.g9324.t1"/>
        <property type="gene ID" value="PSU_v2.g9324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9324.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9688" checksum="038E582BE68B3027" modified="2023-02-22" version="1">MDAFINKCLSFADAATNVTFQQHKVERNERAAILGQHKGFRGCTIWFTGLSGAGKTTISFGLEKTLNQPTQKWLVDSTFNLPNRIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHM2</accession>
    <name>A0A914ZHM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9803.t1">
        <property type="protein sequence ID" value="PSU_v2.g9803.t1"/>
        <property type="gene ID" value="PSU_v2.g9803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9803.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10857" checksum="26118CF9555001B7" modified="2023-02-22" version="1">MECTKTWQQIDIPWMVRPIDENNSILPHSAPSTCGFFTSNCRRAASFPLAHAAAPLPSALKVRSQSESAGLNKIKVSRLTAMQMQMLELENGVRVQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZI66</accession>
    <name>A0A914ZI66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZI66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9997.t1">
        <property type="protein sequence ID" value="PSU_v2.g9997.t1"/>
        <property type="gene ID" value="PSU_v2.g9997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9997.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32204" checksum="81B71392EED6F3B7" modified="2023-02-22" version="1">MEDLEFLEHNINNSVDISLQQDENIMNIGDELFLDDIDIKPSSNALPKAVHQCNICNKIFVSFKGLQQHAIIHTDIKPFTCEICNKSFRFKSNLFEHRSIHSGFVAHACPICGKTCRLKGNLKKHLKTHLSENETIDELWKPFASNRRPPAEVPHDAIIVRSSGDSLSTPVIPRHRKRKLGLGTSASIWIDKIQRGLILSNTSLEVKMQHFLDMLENLQTNGASLKTVFDQARNIAYENFQCPICNLMFPSRGECSEHLDLEHPLARVERPMFCEICLKSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSF5</accession>
    <name>A0A914XSF5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10205.t1">
        <property type="protein sequence ID" value="PSU_v2.g10205.t1"/>
        <property type="gene ID" value="PSU_v2.g10205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="941"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="16">
        <location>
            <begin position="1215"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="514"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10205.t1"/>
        </source>
    </evidence>
    <sequence length="1303" mass="145050" checksum="10BA4DDD30347281" modified="2023-02-22" version="1">MDYHKHHQLNRDQNLDLEGPRRRPFIAENVVRKALGVKVDRFGEECSRFEQDGIYDNDGKAINIDNDISLMDGNNAGYKKEFALAPVHAFVGMIGDEDFFGSGGGDDLRNVVNQPPVDEEDHIKETEDAEPKSIANARSLVAEAREFCVTITAEIRKANVKLKTMNHPRDMIDEESIETLNSMLNGSLSILLEGMLSREASISLLQQDFNELNSYHQNLKEELAYSDSVVARLQNEQKGLSAGTKKRLIGFGCNTVEDLINKHMILQDRFEVLERNIDNRSRISGDSRATSHISLTEKCLNPQAQLMQMEKNKGMSFFIDKKGVSADIKVQLPMPEKFTGKSRTELERFFKLYEAGTNSRGWGDDERAVFLGSYIPRLQLYHDSLTKRNASYKEMKEELLNALGSDGAIATFNMRSQLDRVTKAPNKLYKQLFEEIEMQVTEAFGADCDSREDELKKILLRLTEDDPDPVYRTVVITNVNASYFKLKELVLGMEASQVMHKKVKSEGIRSSLAKANVQVRSSTGKSDVVTPKPQAGGQQSGSGSQQSFSRPQGGSGCFQCHKPGHLARDCPERKPEGTNYVKLEDMKLCVSGIVPVGNVDAKGSLEEPLFGKQALLDVWFDGFKVNALMDSGASTSIIKDTVVGQILSAKDKDGCRIVELPRESYEDKRLIGADGNALMVVNCVKIPIAWGTCPTKVAKFFVVRGLQQNALIGTNVLQDDAGWIEALGSALKSGVKGIQSVGVVQESQKQAFINRVGYDVVAAKTIVIPPQTKVFVKVKTPKTGSVSLIESKRVGIESGVCRSRKGAAWMEFSNQSNELEVVEKGEVVGEAWPTRIVHDIPVEGTNESILTVEADEGQRSFNVKELLDLSAPAFSAEGKLKLTHLVEKYHQAFAASDDEFGKTTVTEHVIDTGDARPIKQPARPVPVPMIPEVKRLVESLLKQRAIERSSSPWNSPVVLVMKKDGSIRMCVDYRRLNAVTKKDAYPLPNQDALLMSLRNKKFFTALDLASGYYQIPMADKDKYKTAFSVLGELFHFLVLPFGMSTSPACFNRMMRIVFGDLIGESVFVYLDDILLATETEVEHLFLLEEILRRLIKFKLMLKPKKCEIARTELCYLGHVISDRGVELGKDKVAKVQNFPPPRSVSQVRQFIGLASYHRKFIQGFSTIASPLLALTRKDTKFCWGDTEQEAFDALKEKLVTAPILAQPDYESAIDGSKPFIIWTDASKTGVGAVLTQEDDDKRLHPLFYVSKACSEAERNYSITQLEALAVVVAMRKLRTLVMGAKVIIRTDHQPLMGLVTRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT43</accession>
    <name>A0A914XT43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Junctophilin</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the junctophilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XT43"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11134.t1">
        <property type="protein sequence ID" value="PSU_v2.g11134.t1"/>
        <property type="gene ID" value="PSU_v2.g11134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000001">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF16">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="499"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="582"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11134.t1"/>
        </source>
    </evidence>
    <sequence length="806" mass="89010" checksum="C71BB7796ED2D938" modified="2023-02-22" version="1">MTETSKVSGVYTWPSGSTYAGQWQNGRRHGLGVEARGRWIYRGEWTQGQRGRYGKREVINASTNTITANYMGTWSAGFNDGYGTETYPDGGTYVGQWQRSMRHGYGIRRSAAYHTALKQKPRSSQRNASLSSLRSVFEEDPAEKPTKDKTDTPECVDGRAGFVLRARSDAPAKRRRSLSERSLAMKRSILSNLRIKKQHSTGDIHQKVTSMTGSLRSSGSLVSCTSDDSEHQRNLHAEMGEPPEERIEPGVIETYKGEWKNDQRSGFGICDRSDGLKYVGEWLANRKNGYGITYFKDGTKEEGRYKNNVLVSSTRRKALLFVRNSRMREKIEASVEAATRASSIASQKADIASSRTQTAAERADAAETMASRAKGDCDVARITASQFDPSFIQPGVQALRRNRDPQRAMLNHISGHPNHVSFDSMLSNTSTSVGGGGPPSISALGARSTQSYQHIPMGGPNRSNNAATAPHNAILQNHLPNPQNRIADSQHQLDKYSRSFDYTLPGPSTSTHTGAGHVNDGYYEQQQQQQQLYHAAQQYGGPSSSSISGGGQQHSDRTPTALHHTISTSNAAGPEDYRINDGASTSTRLDNKSHTSGSHFQGDQASASSLDTSPRIAPLRRNRAGGGSVISLSDDHFDQYTMGKSEDGSRIRRNRPSLTRQSEVNPDALGLNRRSTLASARDRRDAGPTKSTGLGDAKEDRGSLPNLAELEGQGVKLNREDAARLASARRQEDQRLREEEELLRVNPLRYIYHPSLRAWIAKWKVPLLLAIANFFLLYILFHLLTFERSSKITTPSTTKQRPNPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV62</accession>
    <name>A0A914XV62_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynamin stalk domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XV62"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10856.t1">
        <property type="protein sequence ID" value="PSU_v2.g10856.t1"/>
        <property type="gene ID" value="PSU_v2.g10856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin stalk" evidence="1">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10856.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9094" checksum="2CE3EA636C3F3FC7" modified="2023-02-22" version="1">MDRGTNANDMLNGKTIPVKLGIIGVRNRSQEEISNNQSIEECLEKEEKFFLNNYPNIAAKNGMPFLRVQLNKVSYLWHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVE8</accession>
    <name>A0A914XVE8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVE8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11917.t1">
        <property type="protein sequence ID" value="PSU_v2.g11917.t1"/>
        <property type="gene ID" value="PSU_v2.g11917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF19">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11917.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24183" checksum="6A672AC3359BCF58" modified="2023-02-22" version="1">MANHGPSYGLSRELERKNQARFCIEEAQEVLQWLQDVTKSRFEKNPKDFQTAEEVSDALKDGVLLCILYHKIVNKANNVAFRFNQNPKMPFHKMENISNFLNAIKLYGVPEISCFQTVDLYENKQFYKIIECLRALAAVAQSKSAPIPFPNWVVKISQKQKREFTNEQIKGGEAVIPLQYGTNKCASQKGMTPYGLSRQIKQSDTLLNNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVQ1</accession>
    <name>A0A914XVQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVQ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11050.t1">
        <property type="protein sequence ID" value="PSU_v2.g11050.t1"/>
        <property type="gene ID" value="PSU_v2.g11050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11050.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="14241" checksum="5FE994846ADFB63D" modified="2023-02-22" version="1">MYVQQLNDIIFILIQELQTNQLDGQQLLENDSLEYLNLFTVLFCKVRFNREKIVKIHYGIKPELIKSIVNLFQSFDYNPLSPIQYMASIEEVIISKFETRDKSIAMFIIVYHCLQSLCGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWP4</accession>
    <name>A0A914XWP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11387.t1">
        <property type="protein sequence ID" value="PSU_v2.g11387.t1"/>
        <property type="gene ID" value="PSU_v2.g11387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF48">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11387.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11789" checksum="D456DF431F9D989E" modified="2023-02-22" version="1">MVTFGGYNVTNNVQIVPTPGHTTTCISALVNNAETMNSNSVQPLGLVAITGDLFFKVEDLTDATIWKASSTDITKQEESRKAVLCDVDYIIPGHGAMFKVPAAQKVGCPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX50</accession>
    <name>A0A914XX50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CWF21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XX50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11787.t1">
        <property type="protein sequence ID" value="PSU_v2.g11787.t1"/>
        <property type="gene ID" value="PSU_v2.g11787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21373">
        <property type="entry name" value="cwf21_SRRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11787.t1"/>
        </source>
    </evidence>
    <sequence length="429" mass="51052" checksum="B19E751C216824C2" modified="2023-02-22" version="1">MYNGIGLQTARGTGTNGYVQTNLSHLLFSRQREEYNAEADLAKNEAEITKGPNKELLMHEYKRRIEIKCVEFEDLMEEKGFPAEEVAEKVTEYRKLLLTEFEAGKMDLEKELDDRNSHSRAHLAKVGRDRFRNAMGIDDEYKAGSSFEKIRKPGDESEKKATEEVKKEEKEAEEKQAKIAQLMEEIKKEEIMAKLAKNAKKEEKDKKKKKRSRKESSSSSSSSSSDSDSTDTSSSSSSDSEEERKSKKKDKKKKAEPLVRVKEEPQSVREEVPYRPPASERRDDDRQRHRDREDERRHRREKDVERSRRHDDDVDERKDRRSPSYDGGRKERRSRDNDDGRKERRRENDDSRKERRSPSYDDSRKERRSRDDDRKERRHRDDDGDRKERRHGENDDGRKERRHRDVDDRDDRRSSHRRRSPSPKRRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXZ1</accession>
    <name>A0A914XXZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXZ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11821.t1">
        <property type="protein sequence ID" value="PSU_v2.g11821.t1"/>
        <property type="gene ID" value="PSU_v2.g11821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037780725" evidence="2">
        <location>
            <begin position="16"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11821.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31297" checksum="C186AAAEDC6F9E2D" modified="2023-02-22" version="1">MLLAFIISLITYSLAKTISSINNFYCYTDYSIADKPFNFLPKSSRIFEITCGCQHEWKKTFCNNFKRYGKMKTGHSPHVCICRQINDKDSTCDQFMTRCFGDKITKYQSCSCCFNQPDDHCNQLECKNLEPDFGRGSNTSCICHDQSNYPKHICDNEDISPRKKLRPLYTVTGKPYYGITDGTSGFTITDSDNPENSEFYKTILKAVQTNKLILAFIIILIIGVLAAIIFGCCIICFGKKQSNRRTNTRREKRAVNEKRLLEITQNDIEGYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY11</accession>
    <name>A0A914XY11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XY11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12089.t1">
        <property type="protein sequence ID" value="PSU_v2.g12089.t1"/>
        <property type="gene ID" value="PSU_v2.g12089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000604">
        <property type="entry name" value="Splicing factor 3B, subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="26"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12089.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10763" checksum="8606460A5FB9930A" modified="2023-02-22" version="1">MATPLRAGLGGGTGGRSNRLPPEVNRILYVKNLPYKITSEEMYEIFGKFGAIRQIRVGSTPETRGTAFVVYEDIFDAKNACEHLSGFNVSNRYLNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY24</accession>
    <name>A0A914XY24_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914XY24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11857.t1">
        <property type="protein sequence ID" value="PSU_v2.g11857.t1"/>
        <property type="gene ID" value="PSU_v2.g11857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11857.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17373" checksum="804A6C7D04B88E7E" modified="2023-02-22" version="1">MFLGTTQVIDTLFDSVKILCLINTFEKQIEKRAIHVNATWAKRCNKYLFLSYNENITLPYLDLGLPERRSNLWSKIRALFRWTLENEIDNFDFFLKADDDSYFIMENLRFMLLPYNPDEAYYFGSRFKYIVKHGYMSGGAGYILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYB3</accession>
    <name>A0A914XYB3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYB3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12197.t1">
        <property type="protein sequence ID" value="PSU_v2.g12197.t1"/>
        <property type="gene ID" value="PSU_v2.g12197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12197.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18724" checksum="AF577BC532264ED6" modified="2023-02-22" version="1">MTSKSHHHSINVFATVIAFIGFLGSICWLITARWILKLEDGYLIHPILSILGYLYLLIAIRTDNLQKYGNAMGFLILNVLYGIAAVWIVPYVPDLWKPTTENYWGLIIVALTAVYAFMTILVALVAIKSLEEQSDIAMKAAVKYFEENPHLLEEDDEDSKTSTTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYC0</accession>
    <name>A0A914XYC0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XYC0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1153.t1">
        <property type="protein sequence ID" value="PSU_v2.g1153.t1"/>
        <property type="gene ID" value="PSU_v2.g1153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038171485" description="Peptidyl-prolyl cis-trans isomerase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1153.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="10742" checksum="9A96F66747561A3C" modified="2023-02-22" version="1">MIKAFLVALLALVALAAADPAITNKVFFDVAIDGAPAGRVVMGLFGEDVPKTVENFRALCTGEKGLGGSGKPLHYKGSTFHRVIPQFMIQGGDFTHHSGTGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYX4</accession>
    <name>A0A914XYX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYX4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10883.t1">
        <property type="protein sequence ID" value="PSU_v2.g10883.t1"/>
        <property type="gene ID" value="PSU_v2.g10883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10883.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25604" checksum="3371300C953C6F37" modified="2023-02-22" version="1">MTLDLMHDVLEGCAKYLMLYVLKTLPLNELNDAWSLFPFKRNDKSNASMSFTIAQLQKDQLTGLTSSMMLTLIRFLPLVVKESDVTISTKTPWWSIYMDFLTLMDILMAQSYTEERLVDLQNRAESYLERYQRAGGHMTVKSHFLLHEADVIRQMGPLRWSWCMRYEAAHRPIKQYAVVNRNHQNVAMTYAEKIQHSKMNLYQSMNESKLLIAFFDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ02</accession>
    <name>A0A914XZ02_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914XZ02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11765.t1">
        <property type="protein sequence ID" value="PSU_v2.g11765.t1"/>
        <property type="gene ID" value="PSU_v2.g11765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF89">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="87"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11765.t1"/>
        </source>
    </evidence>
    <sequence length="509" mass="54788" checksum="12BC111555FA66AC" modified="2023-02-22" version="1">MPLKNLSYHRAKITPSIAAAIVLHAAAAPSPTSSRDFHSSSSLITSFLGEGKPQHILSSHVLKFKKIQSYRSSSSGGSGNDTSLPSHIKVNLPALSPTMESGTIVSWQKKEGDKLEEGDLLCEIETDKATMGFETPEEGYLAKILIPEGAKDISIGKLLCIIVLNKEDIAKFENYENEIPSEPAAPAVAGKTVVAPPKESLNSVAPQPAEPGDIAVTATPFAKELADKQGVDLHDVIGSGPDGKVLAADIISGGLKSQSPAGSNVEGFVDLPISPLRQTLAKKLVDTKFNIPHYYLTSEILLENVLLVREKLNNLLEKTTGKKSSKPQKLTVEDFVIKAAALACLKVPETNSFYMGTHVRQNQSVNMSVAVNTGHGFVTPVIQNAQSKGLIEINKEILDFSKRAISGEILPHEFENGTFTISSTTFFGDGEANFSAILNPPQACNLAIGKSTKKLIPRTSEEYNEEGITSVSNLTVTLSCDHRVVDGANGAIWLKYFKEYLENPQLMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y089</accession>
    <name>A0A914Y089_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y089"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12198.t1">
        <property type="protein sequence ID" value="PSU_v2.g12198.t1"/>
        <property type="gene ID" value="PSU_v2.g12198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053964">
        <property type="entry name" value="INT1_R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038902">
        <property type="entry name" value="INTS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053966">
        <property type="entry name" value="INTS1_INTS2-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22927">
        <property type="entry name" value="INT1_R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22929">
        <property type="entry name" value="INTS1_INTS2-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 INTS2-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 R3" evidence="1">
        <location>
            <begin position="683"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12198.t1"/>
        </source>
    </evidence>
    <sequence length="844" mass="96027" checksum="C827F47D09A856EA" modified="2023-02-22" version="1">MAIQILIGDITTEEHPINAFSNLPLFNSLSDRICRELSYSVTIESDMKLVMDNISFIAKHMKSGDIHLIALRLTKIVERVGGKSEDHKKVHHALLEFFASYLKSLLSHTAAAEIPKEENDSINEILAVKIPKHSEQFNISSKVLTGMMTLLCESSGATEESNNNRELLLNTWFGTDKNQKPSVRRCSDNAEVNILPDYLKRRMLASIDERIVNAALLGMTVECALDFLQSSAITPFAYSKLLSLVNANKPARGNLRAIATFVRAYKLKGAQGADEFLSYVDEVEGSSSNEQMAFSQQPSFTLDPPPSIQHSLATPEITSSKTIKSFETSKNILSYLEDIKKSNINQLIHDPNWYNFTKVLKQKEKALIVAKFLKSFEISEELLKLILLSFMDGYRIDNITFEPILEDLAETFKAKPNISDLLMNFAQKDVEMDEGKEDIRKLSADEILTRLGRTNEDTPQSEITRLLLRYRILCPEIIESNLSEAEFKRKVLKIFTANVPLMVKLIEELATSEIRQTTRKILNVLLEAYIQSIVPSLVINFVVKCIKTIDPYLQIIPTTSQTIVLIDYVIADMSSFDQSTISILPEFFNVLEALNSKYGMSEFQKVLQNISERIEISLKPPMDEPHLLVLNRLVEELGNVFYGCREVVEQFQKDSSNFTSKTYQPKSMISANLESYFAVIEIFAATESTEQPRIDSAIENLKRMSKNVPKVVAGHLQVITDRIVPILAMTDKKHRDNQHIKLLEIGLEIVMETVPFSFQNSKSLNLLLRPYLEFFYGRITYSQRFERTFELLVECCLGYIMHSPKIGKEFLKNESEFFKAMKGCFKIDELSVLIRQIDDLIMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y099</accession>
    <name>A0A914Y099_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">I/LWEQ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y099"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12206.t1">
        <property type="protein sequence ID" value="PSU_v2.g12206.t1"/>
        <property type="gene ID" value="PSU_v2.g12206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000001">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="I/LWEQ" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12206.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22421" checksum="E6C1C30E9D1F69D1" modified="2023-02-22" version="1">MPDQVSDDLSFDGQILSAAKSIASAVQLLVKAASEAQRELISQGRLDPRPQLSTDDYQWSEGLISAARTVAASVHQLCEAANGLVQGHGTEEKLISAAKHVASSTAHLLVACKVKSDINSTAKQRLQSAGHAVKVATEHLVAAARQAVPQDDRTLVISQQMVSSIAQVMDAQEIVIRKERELYEARNRLAQINKSKYRQSPDDSENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y118</accession>
    <name>A0A914Y118_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase 3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y118"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13901.t1">
        <property type="protein sequence ID" value="PSU_v2.g13901.t1"/>
        <property type="gene ID" value="PSU_v2.g13901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF12">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="35"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13901.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38458" checksum="9E945865D8A52172" modified="2023-02-22" version="1">MINHSGSEGRIDILERQPSAKAFKDAVHNHPIFGPLFGNSGLGVEIFLVLSGFLAARSWYRSSQRKTSSFWGHYFGFIVKRALRLFPSVAVFVWLAQSSLSAEYMPRFYNSMVSTCGVKGLASHLTFTSNWQSTPTCLGYLWYLGLDFQLYIISPLFMAVLLYNSTLGIALIGAVVSASSIYRGYFCWAHDICNKSDVDIPFISFPGQTEAELQKIYYGLWDIYSRPQTKCGPFLIGLLAGFFSLQYSKTVPSIPKLALKYLNFVAIFGVIFCIFGILPEYWYPDAGNTVYNTFYTATFRSIFALCTSWLLFYGIYWFNASSIVFFNVLATITFQVKILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y125</accession>
    <name>A0A914Y125_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y125"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13148.t1">
        <property type="protein sequence ID" value="PSU_v2.g13148.t1"/>
        <property type="gene ID" value="PSU_v2.g13148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13148.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12983" checksum="F45ABDD6F9F0C83B" modified="2023-02-22" version="1">MDTEKALSECPSNASATILMEHQPNGVASVLRTLEKINKRVDLILAGHTHAGQMFVVWPIGYLMNHFFYGLYTYPPSGVQIYVSSGINFWGPPIKMFPSLCEIVKIRLHRDFTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1E3</accession>
    <name>A0A914Y1E3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1E3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13273.t1">
        <property type="protein sequence ID" value="PSU_v2.g13273.t1"/>
        <property type="gene ID" value="PSU_v2.g13273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13273.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25210" checksum="1B5CCBD42C739645" modified="2023-02-22" version="1">MGNRTLDFFQYWIYFQWWKDLRAWGSRNIYTPLAKKLAIVWDGFVYVFGGYWMLPVLQFCGRQAKKAGFITLGYLNQLAIIIGNSVLWPVAVIFYDQLKAGYLIFHAAAVQPVIDVVYLKYKYVEDLTYIHVLGPVCQKVIDNVPEKNPFADDSESELQDFIPDASEAASDSEFSTLSAPETDDEEHAFAKGLHKIAISDSESDNEELSLHHRRSRNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1P6</accession>
    <name>A0A914Y1P6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1P6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12704.t1">
        <property type="protein sequence ID" value="PSU_v2.g12704.t1"/>
        <property type="gene ID" value="PSU_v2.g12704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12704.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16619" checksum="8EF9BE7FA720099A" modified="2023-02-22" version="1">MGQNVSSLINHPLAGFAFSIGAMWLQSLSSPKDKVFGEQLLLQTLKNSSMNFNNNDLKTIMPQQENYIEKMNAMQDTIATLKKALDKKSQESFAKVKQDFDSQLRKNVPMETYFMGTPRKGVKIPGEFKKSAMNAANENEIDRVSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y230</accession>
    <name>A0A914Y230_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SMG8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y230"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12838.t1">
        <property type="protein sequence ID" value="PSU_v2.g12838.t1"/>
        <property type="gene ID" value="PSU_v2.g12838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12838.t1"/>
        </source>
    </evidence>
    <sequence length="747" mass="86013" checksum="18B3B0D26B864C42" modified="2023-02-22" version="1">MAQSFRSFLENASELYKSLLDESLLIVSIIGKDSKTWKKSDIVNNLCGTQACIGQIDSENPEIFIEAYLSTEDSTLFFVLHGVHDFDLQTKLFASDEYKNKSFFEKLAKAEYDELSLLHLLFLLSHLVVVVEQGRYFDTTYMKTFADVNQMRLSAKDHLVDELLHNPQLPKMWSDYGRLSCPRICFLFPDRCIRHELPYSKKKEIAEKLEVGWEAQIFNNLKHIRIVDTSLINCLIVLPEDVRYVHVAKSPSEEPRDLIVDLLSRFLDNSNSSKDDEDIREPDYCTFLRSAMQNILRYGDRFKNFNCFPTLKEFIIGAQITYNTLIEDVTVIKLEEFVPELAIAQSIETSHWERAIHNYRTNCISNGGCFSKAEHLNELEKATDSVKAMVDTGESLREALIKVTETCTEYWENGHQRCESVSVTGHYCKHKIHENDVEHDSGYRFTSSCNCGKKQITRMDPFNLKDANYDFFLQFPCCSNMDSFKFQLFSPSSPVEPTGNVSPDDSERLESPVVNRPNLHRRAKSTASESSKITDTAALSGETIDDEELEDEEVDTVFDRYLDDDKLKELFLDEKDKNKVQRQGTSLMEDEELNDEEEDSDEDEGEEDEEDVEGIGSYLDNYDDNLKLDKPKVLSYDKLLKHYKGQFIEYLPHSNAPPGLLPGFPSWSLKAIGPSNRYSHQHGLRLPNFKHGCDFLLPLDVYLRVNSKDWENDLKKLNPRLDLSARSRRKPLGLDEEEGMNTEKVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2C1</accession>
    <name>A0A914Y2C1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2C1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13386.t1">
        <property type="protein sequence ID" value="PSU_v2.g13386.t1"/>
        <property type="gene ID" value="PSU_v2.g13386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF423">
        <property type="entry name" value="PROTOCADHERIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="136"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="233"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="338"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="441"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13386.t1"/>
        </source>
    </evidence>
    <sequence length="670" mass="74893" checksum="05C914D8F65A9404" modified="2023-02-22" version="1">MNLCKSTGNSERSSSTLVNVLIEDVNDNSPIFVPDTYNITVYEDLPIGTALLSVHAIDEDQGKFGEVHYKIENDNSFFHIDSHNGKLYSDKPLFSFAGQTINVKVVAKDSGGLTSQTSANIEVQILPAEIDCPHFARGLYEFTISEDILPGIVIGTVEAISSRALSYRIISGNNGKFQLDSKSGKLIVSKEQDADKSDIVLLNIEARASDNCASFSQIKIRIHDTNDNAPEFDMPEVETNVAENFPIHEPFFAVQAIDKDKHENGKVTYELIKSEPICPVIVRPLTGQLLLAAPLDFEKIKRYKIIIRAQDQGIPPKTSMTVVNLNVLDTNDNAPEFENQLYDFEVPEDASLMTSIGFVKATDKDSDNNAEISYRFVDERVVDFGINSKTGEIFIRQTLDREIKQDYSFIVLAEDKGIPPLSSNTSIHIRILDINDNTPNCTNISKLRVSEYLNQKDIVGQIEAFDPDAGLNGTVVYRLQQSNEFFEIKRSGEIVLQKRLRQGIFKSPFQLAVIAEDQGPRPRPAVCIIIIELDETKSDVELLEPVERTIKINTNDEIGTKLVNIKALNAYQWNIEKSGISNFFVINNGTLSLNQKPDEIKFEKPQPLSVAIADSKGRKRYLSFIVRLHHLSTPDNETIVTKVKETTAIGTKIIKPFLSPSELYLILTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2E1</accession>
    <name>A0A914Y2E1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2E1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13620.t1">
        <property type="protein sequence ID" value="PSU_v2.g13620.t1"/>
        <property type="gene ID" value="PSU_v2.g13620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038057464" evidence="2">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13620.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="20019" checksum="489A34148E2DE556" modified="2023-02-22" version="1">MIFSVIFIFCTLVELAIVCQLNRWERERQIGSKVLGHWLNQIRKTRKSDGKSNGSDNDGVRKRFLLTPIHKDDDEVAKTNFVKRAFSKATTDVTVITPDDEIEDIRQKKYHWWLSLSERLSQTLCPPDRDWTVTSVQVDRCSMIMFPFSFLIFNIIYWCIYFTKMDRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3A2</accession>
    <name>A0A914Y3A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3A2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13928.t1">
        <property type="protein sequence ID" value="PSU_v2.g13928.t1"/>
        <property type="gene ID" value="PSU_v2.g13928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13928.t1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37830" checksum="05E6171B8005A308" modified="2023-02-22" version="1">MVETASDIINLGNRTLSNLEIDHLKTAFIGLSAQTRHETPPRTITIHSISTESADSKMIAMPDGDKSVAAYFLERYGIRIQYPKVNLVIESGPQKSEFPMELLQICDNQRVRTEHQTPELVQNMIRACAVPPSTLIPQNLRNGRALGLFGENRSPHLAAMDIDVVGTPVTVNTRVLPPPYIQYRNNSTATPEPARATWTQRAYYLLPCDLGKWAVYILGSAPRNRSRFEQQELQQFLSCFQQQCGKVGVNYVAPAYMSAIPIDVGKVEEEFAECKRAGINFMFFIHADNDQSLHKVVKLLERQYEIVTQLVKMQNAGDIVSKGKQQTMENIIHKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3C9</accession>
    <name>A0A914Y3C9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alanine--glyoxylate aminotransferase 2, mitochondrial</fullName>
            <ecNumber evidence="28">2.6.1.18</ecNumber>
            <ecNumber evidence="12">2.6.1.40</ecNumber>
            <ecNumber evidence="5">2.6.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">(R)-3-amino-2-methylpropionate--pyruvate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Beta-ALAAT II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Beta-alanine-pyruvate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">D-3-aminoisobutyrate-pyruvate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">D-AIBAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">D-beta-aminoisobutyrate-pyruvate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="40 41">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="41" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="38">Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77339"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:18393"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.40"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:18394"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:77355"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate</text>
            <dbReference type="Rhea" id="RHEA:77363"/>
            <dbReference type="ChEBI" id="CHEBI:35177"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:58455"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate</text>
            <dbReference type="Rhea" id="RHEA:77359"/>
            <dbReference type="ChEBI" id="CHEBI:28644"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:58441"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>3-oxopropanoate + L-alanine = beta-alanine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:14077"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.18"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:14079"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77331"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58802"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77327"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58802"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77315"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:197308"/>
            <dbReference type="ChEBI" id="CHEBI:197310"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77307"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:197308"/>
            <dbReference type="ChEBI" id="CHEBI:197310"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate</text>
            <dbReference type="Rhea" id="RHEA:77351"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77311"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:77343"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77303"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77323"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
            <dbReference type="ChEBI" id="CHEBI:197314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77319"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
            <dbReference type="ChEBI" id="CHEBI:197314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24249"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>oxaloacetate + L-alanine = L-aspartate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:77347"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 39">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.18" evidence="28"/>
    <dbReference type="EC" id="2.6.1.40" evidence="12"/>
    <dbReference type="EC" id="2.6.1.44" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y3C9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14695.t1">
        <property type="protein sequence ID" value="PSU_v2.g14695.t1"/>
        <property type="gene ID" value="PSU_v2.g14695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047305">
        <property type="term" value="F:(R)-3-amino-2-methylpropionate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016223">
        <property type="term" value="F:beta-alanine:pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019481">
        <property type="term" value="P:L-alanine catabolic process, by transamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000055">
        <property type="entry name" value="Alanine--glyoxylate aminotransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF3">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 39" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="40" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00043777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00043798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00043825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00043826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00044055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00044257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00044258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00049480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00058068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14695.t1"/>
        </source>
    </evidence>
    <sequence length="431" mass="46852" checksum="5083C9A04419E11D" modified="2023-02-22" version="1">MVTYYQKPILIEKGSMQFLYDSNGKKYLDMFGGIVTVSVGHCHPKINEALKVQADKLWHTTSIYYTSAMFEYAEKLTATMPENLSVCFFVNSGSEANDLALELARLYTGRFDCLTVRNGYHGMTQTVAGATNLGNWKQPLPSGFGLLKTMCPDPYSGPWGGSKCRDSPIQTKRNCDCSSSDDCKAGKEYFRQFEECLQFDFPAATGPAAFLAESIQGVGGTVQYPKTFLPKAYDAIQKSGGICIADEVQTGFGRLGSHYWGFQANDVKPDIVTMAKGMGNGFPMGAVVTTPEIASVLKSALYFNTFGGNPLASVVGKAVLDVIEEEKLQENCEKVGTYFLKELAAIDSPLIGDVRGKGLMIGVELIDENGAKMPASRMANIFEFIKDKGVLTGKGGRFGNVLRIKPPMCITKSDVDQAIDAIAEAIKTVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4N6</accession>
    <name>A0A914Y4N6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4N6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14198.t1">
        <property type="protein sequence ID" value="PSU_v2.g14198.t1"/>
        <property type="gene ID" value="PSU_v2.g14198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20552">
        <property type="entry name" value="CYCLIN_TFIIB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000019">
        <property type="entry name" value="transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14198.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33246" checksum="67DA716D429F02F0" modified="2023-02-22" version="1">MASLTCPRHPDAHLVEDHRAGDIICPECGVVVGDRLVDVGTEWRSFSNERSGTDPSRVGAPENPILGTGDLSTSIMVGFGASESSQGLANAQRKNTNNTERQLNQALGIIRDMSERIHLTRPIQDSAAKVFKQILDSKALRGRSNEAQAAACLYFACRKEGVPRTFKEICAVSRVSKRDIGKCFKLILKTLETSIEQITSADFMSRFCGNLNLHVSVQAAATRIAKKAVELDLVAGRSPISIAAAAIYMASQASTEKRSAKEIGEIAGAAEQTVRQTYKLLLPRVRELFPQEFKFDTPIEQLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5P2</accession>
    <name>A0A914Y5P2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5P2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14756.t1">
        <property type="protein sequence ID" value="PSU_v2.g14756.t1"/>
        <property type="gene ID" value="PSU_v2.g14756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14756.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16793" checksum="3A501E4D7151ADB1" modified="2023-02-22" version="1">MGYPFPSKTLTLAHVKTGSVASFDANSMFTFGPRTYKRSREEESQVHDLLKSGHDKYTADVPNTAFYLIRGPTGCGKSTLTPIMILKAAPSKWVLIEEPSRLLVEHTSKNINDLTGSITAGYMHRYGNSVNLSNRATGSFVFTPGCGKVFLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y660</accession>
    <name>A0A914Y660_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y660"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14929.t1">
        <property type="protein sequence ID" value="PSU_v2.g14929.t1"/>
        <property type="gene ID" value="PSU_v2.g14929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14929.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11108" checksum="8BA08739E45F6009" modified="2023-02-22" version="1">MFSFDALQEKATTVDASELPGMLETLESWTTYTESFLKHIEAAVSESDKNLSVRMQKEREIEKFAAQHKENGRTTENISELISFDGPKDTVKRSKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6D3</accession>
    <name>A0A914Y6D3_9BILA</name>
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        <submittedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6D3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15008.t1">
        <property type="protein sequence ID" value="PSU_v2.g15008.t1"/>
        <property type="gene ID" value="PSU_v2.g15008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF176">
        <property type="entry name" value="CORIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15008.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26979" checksum="91381880C5F50A6E" modified="2023-02-22" version="1">MNRIRNGEFTPDDLFQFTVKVHNPVSVCTGSIISKRYVLTAAHCIKEQESSPKIKYDTYEVYQNNINYAEVRPLNIFDKSKMPKSINAYITKNFSQWYSNDIAILEFPEGTDFGIEPVKLAKDYFEKEGDEAYITGFGAWWEEGNKTSGGSTVLRHASVPFVMECLGTLRICDGNSTHHGLQGDSGGPMIIQRNNQWYQIAVASGYSHQDGHKYDLFMAFSFLIFVQKMLNQVLQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6R8</accession>
    <name>A0A914Y6R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6R8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14448.t1">
        <property type="protein sequence ID" value="PSU_v2.g14448.t1"/>
        <property type="gene ID" value="PSU_v2.g14448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14448.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12988" checksum="4078EB3336618A44" modified="2023-02-22" version="1">MNLIFYSCVHVSTLIIFKKQATCLEDWDSFVCRIKRTPINTHQFLSYNGTEKPKNSDEVNHILVIRGDKQPNKLRECSRGCTFSDISHPNYITIETELQGDPTLQTQVTQPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y722</accession>
    <name>A0A914Y722_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y722"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15068.t1">
        <property type="protein sequence ID" value="PSU_v2.g15068.t1"/>
        <property type="gene ID" value="PSU_v2.g15068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15068.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13764" checksum="21219B6E0BBEA7A2" modified="2023-02-22" version="1">MDFTGDNSLIYRDLYGLIHINKFFVEDLKEFPRSDDAEMIKDLDVFLDQHYEDSVILFLEPDILERQAHWNFDLRWGKKDLKTIVFDFLNDLTDEIHSIIEEIAYTHFSANCVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y723</accession>
    <name>A0A914Y723_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Parafibromin</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y723"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13428.t1">
        <property type="protein sequence ID" value="PSU_v2.g13428.t1"/>
        <property type="gene ID" value="PSU_v2.g13428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000002">
        <property type="entry name" value="protein CDC73 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032041">
        <property type="entry name" value="Cdc73_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16050">
        <property type="entry name" value="CDC73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paf1 complex subunit Cdc73 N-terminal" evidence="8">
        <location>
            <begin position="68"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="7">
        <location>
            <begin position="349"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13428.t1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57662" checksum="C46067CB3C49982B" modified="2023-02-22" version="1">MDGGVLAAMHQCIVQGDTFKKVEKDGKLYYKILDTYYPFDTPSNVKTFDSEGGFYSVGTVGTFYLNHENQAYTRNALELNVELVPRPHRKAISVYIQKGIRNPDLVLADAPTIAITSAEFEESETAIEEIDKSSLNQSSIDDTGRQMDTTTTSVRDLSNDLTAERIAQLASKAKQVRTQKSKTDRGFLLDAEISDKSLDSIDKYFKHKTRVHKNSTNCMDTAATFTSILSLMSSMKSREPPANAIPKPPLAPNLQSNVQAKTNASAQNNRGYSRYDQEVFHNDEADEFQIQTGMSFHGTSLKKINNLKTAAKPIADPSRQALKRPYPSMSASSASNNAAANNKPQKRISKTPIIIIPASGTALISMYNAMDIFQDLKFVSTEEKKRIIQRRENELLIHRRKENGHTVPYRIVDNPSRLNDEEWDRVVAVFVQGPAWQFKGWHWGGNPTTIFSHVCGFHLKFEDAKTDANVAKWAVDVLSLSKQKRHLDKAIFIRLWQKIEQFIIRNKPALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y798</accession>
    <name>A0A914Y798_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y798"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13501.t1">
        <property type="protein sequence ID" value="PSU_v2.g13501.t1"/>
        <property type="gene ID" value="PSU_v2.g13501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031053">
        <property type="entry name" value="ALC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="33"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="321"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13501.t1"/>
        </source>
    </evidence>
    <sequence length="485" mass="55542" checksum="8578F8CF203E84E9" modified="2023-02-22" version="1">MNNLCKVDDILPLLKNSGLTLREHQINGIETILKWINNNHGGILADEMGLGKTCQAVIALDLFAKSLPNAKFLIICPLSVIEHWENELTRFGCGILKIFTYKGYKDTREKLRPRFSANDWNICLTTYTYFRLDHDWFNFSIEIVIIDEAHSVKSQQSQLHQLVRKKQCHFYILLTGTPIQNNLNEFYSLLSLADNKEFDESAEEREKFFDLPRKNLEKKLKEATEKYVLRRLKSEVCKELPTSQEVILLHSLTSFQKQLYNAVLVANHGFFEQTTSQRQSLMNVLAQLRKAVAHPYLFPGVEPEPFTEGEHLITASGKFMVLDKLLKFLKAANHRCLVFSQYSRNLEILADALSFRGYKYEHLDGSTKAEDRFQSIDNFQRPDSDIFCFLISTKAGGQGLTLTAADTVIFLDSDYNPQNDLQAAARCHRIGQNKPVKVIRLLAEHTIDNVIRKRAEGKLKLSDFVLDDNSGLFIICKCSSRSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7G5</accession>
    <name>A0A914Y7G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7G5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13561.t1">
        <property type="protein sequence ID" value="PSU_v2.g13561.t1"/>
        <property type="gene ID" value="PSU_v2.g13561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000055">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000052">
        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="241"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="449"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13561.t1"/>
        </source>
    </evidence>
    <sequence length="599" mass="68421" checksum="4574F0AA67450F29" modified="2023-02-22" version="1">MDMNITDTSMMPSTDIESTSIDGVSEGGTTISTSKTSLNEEITHSGITEAPNEENIPQRVILRLKRKAPTSSEEGSKIDDDDWLEDITFESKEILSINKKLLDRLEEENSTIPMGSAWIQIDATDEASPLMYILSNEAANCLNLKVPKHHFQRYEKVVLYLPGICSDYVPTAIDAFNASDFEGVEIEGPIGVNISALEAAGVNLTELAEKLRNDTEVDEILTRTNGTTRTLGGSYILPVLHKNQYDPFSAPIVFQGSAVAVRFGIYIESMSNFQTSTMDYDMDISLLMAWRDARLVNPYDKPILVKEEEILEKIWRPDPFFANAKEAEFHEVTFLNFLMRIFNDGLVLYETRVKLKPACNLILCKYPHDKQTCELAIKSFAYPMETVRFEWFTRKHDAIDKNPDVKLPELYIDRYEPSICNRTRKSGEFSCLRAVFRLKRDVGFHIAQTYIPTSLALMFSWVGVWLPEEFMEGRIGVAITVLLTLSTESAGAREHLPSAIDLWFGYITGFVFFTLLQTLFVIGFDKRANQLKKWATKKRLDVTQEARDSMLNKASRYHKTGRYLDNFCRVFYPLSFLLFLIMYYFVFTEGRQDDCISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y858</accession>
    <name>A0A914Y858_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y858"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15634.t1">
        <property type="protein sequence ID" value="PSU_v2.g15634.t1"/>
        <property type="gene ID" value="PSU_v2.g15634"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g15635.t1">
        <property type="protein sequence ID" value="PSU_v2.g15635.t1"/>
        <property type="gene ID" value="PSU_v2.g15635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15634.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15635.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27902" checksum="F0738EAC4C44A4EB" modified="2023-02-22" version="1">MNLSQQPKKELIINEILVMRENKHENIVNYLDSYLVGEELWVVMEYLAGGSLTDVVTECEMEEGMIAAVCREVLQALDFLHSRNVIHRDIKSDNILLGMDGSVKLTDFGFCAQIQPGSKRNTMVGTPYWMAREVVCRQQYGPKVDVWSLGILSIEMVEGEPPYLNENPLRAIYLIATNGRPDFPSRESISPLFRSFIDAALEVDVDKRFSSKEMLRHPFLKCARPLNGLRHLIEAAKRSILESNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9M3</accession>
    <name>A0A914Y9M3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal lipase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9M3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15980.t1">
        <property type="protein sequence ID" value="PSU_v2.g15980.t1"/>
        <property type="gene ID" value="PSU_v2.g15980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="131"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15980.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34275" checksum="9FFFDD57A56019C4" modified="2023-02-22" version="1">MKSELFLETPILNRSNFVSNLSKKWCTSTSTCFLSIENSKCPNADDRVKLGYECVIEPPKGDEYDDGFVRTKILPYIAASNALNMDQIQTCLDNHFVGAKAFKQYYQICDKQNSTCAAFLAVSPDDKAIILSFEGSKGWSQLVNEGVDFMFDKTVEFPEVGGKIDKYYYDGFYTLWNVGGIKTDVANLAAQYPDYEFWCVGHSMGGSLASVTSAIVIKDGTFKAQKVKLVTFGQPRTGDEAYAEAHDNLVPYRFRVVHNKDKVPHLPWQTNPADQPYHHRFEVWYPNDMTPGSSYKVLHPCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9V2</accession>
    <name>A0A914Y9V2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bleomycin resistance protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bleomycin resistance protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9V2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15540.t1">
        <property type="protein sequence ID" value="PSU_v2.g15540.t1"/>
        <property type="gene ID" value="PSU_v2.g15540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08349">
        <property type="entry name" value="BLMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000335">
        <property type="entry name" value="Bleomycin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19581">
        <property type="entry name" value="Glyoxalase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15540.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13472" checksum="9B7FE9E10E514414" modified="2023-02-22" version="1">MPQTVIPQLRMRHADTTLPFYVQGLSFVVDWEHRFEPGFPLFVQLTRDGQTIFLTEHSGDCEVGGAVYFIVEDVDALHRAFSAAGVPIEQPPHDTEWGSREMLLRDPDGNRLRFATDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAW6</accession>
    <name>A0A914YAW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAW6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16567.t1">
        <property type="protein sequence ID" value="PSU_v2.g16567.t1"/>
        <property type="gene ID" value="PSU_v2.g16567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF18">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16567.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14035" checksum="FEB58F59965C8F97" modified="2023-02-22" version="1">MKRPPRDSKVDRLVNFRLMRFSYLQIGMIQTLAGFLTWTAVMAQNGFCLDRLFNIRTHWDNKAVENLEDSYGQEWSFHDRKTLERSCHAAFFFAIVVLQWADLLISKTRTNSLVTQGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBR8</accession>
    <name>A0A914YBR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBR8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16205.t1">
        <property type="protein sequence ID" value="PSU_v2.g16205.t1"/>
        <property type="gene ID" value="PSU_v2.g16205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16205.t1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11604" checksum="9FA17F2B0FEB7DA7" modified="2023-02-22" version="1">MCNVAKHAGGRFATGAAIIRAVRANKDGVDKATQQGQFPAHLGMDGIERGHGKQTTRQTGLVGGNDHLPAVFGQRAKASRLPGMASHSCGLFKGIAVMVDDTVPINDGKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC38</accession>
    <name>A0A914YC38_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC38"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15041.t1">
        <property type="protein sequence ID" value="PSU_v2.g15041.t1"/>
        <property type="gene ID" value="PSU_v2.g15041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15041.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10061" checksum="8DFEBB136B045C2B" modified="2023-02-22" version="1">MAQQPNALGQQSGTFGQQSGTFGQQPGALGQQSGALGQQMNNGVGSAGQQPLGPAGIPIVGNAQGGNMQNPNQPQQQPFGSNLGFNSMQQQPGMNPSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC84</accession>
    <name>A0A914YC84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1690.t1">
        <property type="protein sequence ID" value="PSU_v2.g1690.t1"/>
        <property type="gene ID" value="PSU_v2.g1690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003800">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF247">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-6 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="151"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="220"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1690.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35314" checksum="80B43BE262050952" modified="2023-02-22" version="1">MKILHLNGFTDVDKANFIDPIRRNTIDSLLQLLAACKEIKIAHDYSIQIALHEFEIWACQMKTIQENIEIPDRMIRCIQIIWKSGGIQTAYKKRWSFYLLDSAKYFLDSVARIGGDDYLPEVQDIVQCRFPTQGTEEITFRYENMNFCMVDVGGQRSERRKWIHCFDNVSMLLFVAALSDYDLLDPENNNQKRLSANRYIFKTIVQSSFFKEAAIVLFLNKFDTFTEKLKHQPLSKYYPEYTGSSDPNEASDYVGSQFRKCVRDKNKYFMFCTTATDTRNVEFVFASAVTHIINQNLRATGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCL4</accession>
    <name>A0A914YCL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16491.t1">
        <property type="protein sequence ID" value="PSU_v2.g16491.t1"/>
        <property type="gene ID" value="PSU_v2.g16491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16491.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="11238" checksum="BB34668E53C2F5EA" modified="2023-02-22" version="1">MSPEARQYLQGPKTPFLTVYFAFGAEYSEYITDDMDVLPKLSVAHQLVIALQPRFPEFNRRKALTWLRRELPRIRENYTSFERKTMPFPFKWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCS2</accession>
    <name>A0A914YCS2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YCS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16545.t1">
        <property type="protein sequence ID" value="PSU_v2.g16545.t1"/>
        <property type="gene ID" value="PSU_v2.g16545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000023">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF495">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="496"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="847"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16545.t1"/>
        </source>
    </evidence>
    <sequence length="1033" mass="116395" checksum="7F081076774BC1A2" modified="2023-02-22" version="1">MFPRGISSLDATISYSRTAGGLTVAMNKILDAKIWQNINFTVIYYFDQCNEALAAGGAVKLIRDEKVDVIIGPACSASVAMAATVAAFYNFPIFAWSTVLAADLSDGTKYPTLASTSINSYTLSQALGDLFAYFQWNEFAFFYSIILNSASPRCSYYQADLDRYVSVNDITMVYKKQTTADSYVELRAALRRMKTQARIIVTCYESSSKKREFIAAAMDEGMTTNDYVFVYLQTAQNGFGTIPFWVDTSAKPDGRDEQIKKASKNIIILDLEQLPSTFKTFNTEVYNAMFEWPINCQESNDCPPVGANMTKQAAYLTDTFFLYASALNKTITQYPNDPDAVRNGKIINGNTAKTKFAGYSGQVRINENGTREPVYNVLGLDSNWNPQLYFVIERKDNETSNIIPQFKDEKTTLWGHRGGFRPLSHPVCDFDGSACPPSVLETYLGFIIGGIILGTVTILNHEKMRIENRRKMDELWQIPFVRLSKPSEKKQSHSPRSTISSLGSSSARLSASNKEATEHFDFYYFNNELLAAKKHNSRPKLTEKDNILFRKMQQTSHDNLCRFMGLSMDGPMYLSLWKYCSRGCLRDVIAHSNVTMDGFFMTSLISDIVEGISYLHNSPLFQYHGDISSKTCLVDERWQVKITLYGLYPFKVYEKRDHESLLWCAPEILRSDEEFYGNAAADIYSFAITASEIVTQKAVWAIGDNNELDSEEVVYRVKKITKTPFRPALSVDTFLDVNPSLLHLIRDCWSDEPKDRPTIKVIQTLLKSMQNGKSKNLMDHVFNSKIFYVFLEQYANNLEQEVEARTKELAEEKKKSDILLYRMLPRTVADKLKLGQSVEPESFDSVTIFFSDVVGFTVIASKCTPIQVVNFLNDLYSTFDTIIDEFNCYKVETIGDAYLVVSGIPIRNGNQHAVDIAEMSMGFLKAIKNFKIGHMPNEKVNIRIGLHTGPCVAGTVGLTMPRYCLFGDTVNTASRMESNGKPGKIHLSPSTNHYLTKLIGGYQSVSRGEIIIKGKGVMETYFLCTGDENKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD18</accession>
    <name>A0A914YD18_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YD18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1733.t1">
        <property type="protein sequence ID" value="PSU_v2.g1733.t1"/>
        <property type="gene ID" value="PSU_v2.g1733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040022">
        <property type="term" value="P:feminization of hermaphroditic germ-line"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="399"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="588"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1733.t1"/>
        </source>
    </evidence>
    <sequence length="851" mass="96396" checksum="68A4EB859D798483" modified="2023-02-22" version="1">MDVKRWVNDELHSIFGLSDPQLASFMISIASSAASVDSFLNRLKEMEDELAANQRMRQFAQQLIGKVRQPAKPTSSAPRETAQQKKLKELELANARYHALSSGSDDEDTRIKSIPKSKKDDKRPSKNLRQRKESSSEEEVVIPQKNRNTRQMDDNDSDDGDIDKMDAEDEDDARGRDEFHIRVREKDKRNTRKIVSKSDAKAAAEAEKRLNIANTNDKSLIKSARYASRQQYLEKRTADKQYELERLVADDEGMFDESELNAKERADRKYRKEVLQYVNEYNKAGDIINKKRYHVPDATTKSIPTDYVEEEELPGGDGRRWEDERLTAAVFRAGARDRIKEDFTDELMLEEEIDFIQAMKMPGTSEHVEPELSATEKKKMSIEETRKSLPVFAFREEFIQAVKDHQVLIIEGETGSGKTTQLPQYLYEAGFCEGNKRIGCTQPRRVAAMSVATRVAEEVGTKCGIKVGYSIRFEDCTSEKTMIKYMTDGMLLREFLNEPDLASYSVMMIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATLDAEKFSKFFDEAPIFRIPGRRFPVDIYYTKAPEADYCDAAVISVLQIHLSQPLPGDILVFLTGQEEIEAVQEALLERVKFLGSRIKELIVLPIYANLPSDMQSKIFEPTPPNARKVVLATNIAETSVTIDGISYVIDPGFVKQNSYDAKSRVEYLNVVTISKAAANQRAGRAGRTGPGKCFRLYTAWSYQNELEDQPIPEIQRTNLGNVVLMLMSLGIYDLIHFDFLDPPPHETLVSALEHLYALGAVNHKGVLTKLGRRMAEFPTDPAMSKMILASEKYECSEEIITICAMLSDFGLPSVIISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDX3</accession>
    <name>A0A914YDX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chloroplast protein-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18431.t1">
        <property type="protein sequence ID" value="PSU_v2.g18431.t1"/>
        <property type="gene ID" value="PSU_v2.g18431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1440.10">
        <property type="entry name" value="SecA, preprotein cross-linking domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612:SF0">
        <property type="entry name" value="CHLOROPLAST PROTEIN-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="Pre-protein crosslinking domain of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SecA family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18431.t1"/>
        </source>
    </evidence>
    <sequence length="528" mass="60249" checksum="157143871F19CB90" modified="2023-02-22" version="1">MIQKFENSEAYQKVISEKVRNVDVIANLIKGVHDSDLLTRKQASQRIANIIKNPGKSKVMRLLEKFDNCMKVLRKGISLRDTQKMAIMYAIESNSNLLSQVNTGEGKSYIVAAIAIIRASQFQSVDIITSSPVLAQRDSAEMKDLYEAMSINIDHNCHEDVEKRKQAYKANVVYGEIGRFQRDYLLHHFYRKNILGDRSRENSCVIVDEVDNMLLDNGNNMLYLSHSVPGMEMLEPLFVHLERMIFIPTCKGNKEKTFATETIEASVLSDLLGRLSMDDIELMANTSEAKTKCFAVWTHLIHEQIIDSEGYLLLEKDSDFEVIRLQISSALKNLTTEIHAKKIITCLKAIVNRRREIFVPRYLIPFIRRHLSDYIENAKRALFMKSNEAYVVDVDHTQQDSDITPKVTIIDQNTGVDLATSQWSEGLHQCVQIKHGCRVNPISMKAVFVSNVNYLKGYSRINGLSGTLGSHEESRTLVDLYQADLIKVPTFRAKRLYEHVPVIAKDEGEWLDAIFEEVADQLEILKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE98</accession>
    <name>A0A914YE98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE98"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17764.t1">
        <property type="protein sequence ID" value="PSU_v2.g17764.t1"/>
        <property type="gene ID" value="PSU_v2.g17764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009502">
        <property type="entry name" value="SecM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06558">
        <property type="entry name" value="SecM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17764.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8087" checksum="ADF41E26D62E0368" modified="2023-02-22" version="1">MAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEW6</accession>
    <name>A0A914YEW6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEW6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17294.t1">
        <property type="protein sequence ID" value="PSU_v2.g17294.t1"/>
        <property type="gene ID" value="PSU_v2.g17294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17294.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="48369" checksum="2C45CCE075F27230" modified="2023-02-22" version="1">MNATKATEKLRAIAKAAISRATNKSIEASTTTSSSTTESTTTAPLATTATEAEKVVKEEKIVQEADEESEEEAEEEEEATEAEETPEVDETSTATTDPVVFKQAPIRIPEAEEEEIPTKDQEHVEVSFQETGTTSTTRAPLSGQTVYNLNANANSASDPAISNVFTPVNAIVDGIGPLILPLIGYSRQALQYYPRAQGANTYQPDNSGKPVQLRSLPKGYGFGGGQEQQQQASSAAANYARGTPIQQQQTLSSLKTATTDQLIEAFHRASKANNLATSPPRPYSRYVPNPSSVNSYYTQGNSQQNLEQLRKAFVQSNQPEYNLKQPQEIFGTTLATEPTYYGPQIDRHIGQNLFTQGVRHREETPKSPLPIEENPDPAYAEGLKKVTAFVGDSGVMTGDENAAEALQESGLPPVRKSSNGFGGGHGPNASFDEVVKNTEQEPSYSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGV1</accession>
    <name>A0A914YGV1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="11">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A914YGV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16546.t1">
        <property type="protein sequence ID" value="PSU_v2.g16546.t1"/>
        <property type="gene ID" value="PSU_v2.g16546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16546.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32276" checksum="0A4E53795C3A1DC7" modified="2023-02-22" version="1">MKFYIFDDSVIISGANLSDQYFLNRQDRYVLIENNPKLVDFLENVFNTIAASSFQLKENGDLDLSDNCIHPFEGNKAAFCEHVSTQVRSILSTLHTESSDSMISPSSTPASDTRIYPFLQFPPFKINDEVEILMKLFSHSDNDIDVTVATGYFNLYDDYLDAILKKSNYPLTFLTAAPDANGFYNGQGLSGYVPSLYVNTSKFCFDQAKIHQKQIKILEYSRPNWTFHGKGIWIDDEKNGLTATMIGSSNFGYRSVSRDLEAQIMLVTSNEKLRSRLKEVKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHP9</accession>
    <name>A0A914YHP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16831.t1">
        <property type="protein sequence ID" value="PSU_v2.g16831.t1"/>
        <property type="gene ID" value="PSU_v2.g16831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16831.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10017" checksum="A98DB05D56C4824E" modified="2023-02-22" version="1">MHQGLVPAINLFQSCEPKIDGVDKMVKLYVDIDSKCPIKVINAKIHVPQVPTPNPSSNSTSNDESSTASVPWWAIVIMVFVGIAAIIIIVGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI11</accession>
    <name>A0A914YI11_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2">1.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dihydrolipoamide dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YI11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18439.t1">
        <property type="protein sequence ID" value="PSU_v2.g18439.t1"/>
        <property type="gene ID" value="PSU_v2.g18439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="3 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="16">
        <location>
            <begin position="171"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="15">
        <location>
            <begin position="328"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18439.t1"/>
        </source>
    </evidence>
    <sequence length="449" mass="48406" checksum="5F2F129CA904EA0B" modified="2023-02-22" version="1">MYSVCRHTLTRQPVWNISLRAFSSKQDADLVVIGSGPGGYVAAIKAAQLGMKTVCVEKDMTFGGTCLNVGCIPSKSMLNNTHLYHLAKHGDLKARGIEGDVTLNLDTMLKAKEKSVKELTGGIAMLFKANKVNGVKGYGTISSPNEVTVNKEDGSTETINTRNILIASGSVWQRLGAEVTAVEFLGHVGGMGIDADVSKNFQRILTKQGFKFLLNTKVTGAKENGGNITVSVEGAKDGKKQDLECDVLLVAIGRRPYTKNLGLENVGLKTDERGRVEVNDRYQTSIPSIFAIGDVIHGPMLAHKAEDEGIICVEGIAGGPVHLDYNCVPYVIYTHPEVAWVGQTEEQLKEKKIAYKVGKFPFAANSRAKSNNDQEGYVKSISDKETDRLLGVHIIGPNAGEMIAEATLALEYGASSEDIARVCHPHPTLSEAFREANLAAYCGKPINSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YI61</accession>
    <name>A0A914YI61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YI61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20021.t1">
        <property type="protein sequence ID" value="PSU_v2.g20021.t1"/>
        <property type="gene ID" value="PSU_v2.g20021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20021.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8517" checksum="FED1201AF7B7F1D5" modified="2023-02-22" version="1">MDVGNGQPRLPNCRQQIAQVMTLFAVGQGVEQAHAVGSALQSQRFQRSGQGADRLGQIQAQGFTAQAAHQIVFGFHQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIJ7</accession>
    <name>A0A914YIJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S2</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIJ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19327.t1">
        <property type="protein sequence ID" value="PSU_v2.g19327.t1"/>
        <property type="gene ID" value="PSU_v2.g19327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19327.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="26637" checksum="C2355F4126D1E5C2" modified="2023-02-22" version="1">MYYIAKNPKNAEVYQKMIKICKYFFVKNPILVISNLHYYQNGWGTRKNDGWNSIDMNRISAKLWITDRLPVYRQHVSNNSLVSSIIPKIYQCDAKYLILCDQVISLNELIFLCSSAEALDFKRVTVKNGTVLAFEKFFEQLPQIKVIYYTFSTPSNNTTKNTFKDTWKISHLSNSFHFYLFNIPQNFDIDIFYSYMKYCLFFGFNNDSHILSRHIKYFLEKQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIM6</accession>
    <name>A0A914YIM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18676.t1">
        <property type="protein sequence ID" value="PSU_v2.g18676.t1"/>
        <property type="gene ID" value="PSU_v2.g18676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18676.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14872" checksum="87374B4F9245EA61" modified="2023-02-22" version="1">MNRVPLTVYSTPACHGYCHHHFGSSSTSFAYQYPSISIFDQVSIAPSFLYVPVPIQQLPSQYAPSYLPTNYSNILPGQSAHLYPNGGSDNPNPFYEPLTTPEMPSPPPRLRRGLRDQNEVVAKKPKTEHNDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIP9</accession>
    <name>A0A914YIP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1870.t1">
        <property type="protein sequence ID" value="PSU_v2.g1870.t1"/>
        <property type="gene ID" value="PSU_v2.g1870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1870.t1"/>
        </source>
    </evidence>
    <sequence length="72" mass="8008" checksum="FCDA9666A9FE8B64" modified="2023-02-22" version="1">MGSTHSTKKNILYPHPIVETEYGLIEGMNVLIPKDSQKRIAKVFLGLPFAAPPLGNLRFEQQVIIIQKFAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKR4</accession>
    <name>A0A914YKR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19934.t1">
        <property type="protein sequence ID" value="PSU_v2.g19934.t1"/>
        <property type="gene ID" value="PSU_v2.g19934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19934.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10165" checksum="E20FB148F6E967EB" modified="2023-02-22" version="1">MGPPTGNGVGSGNNNNFNQNNSNQSSSTSHHQKKYASTFGGGGGGSDDRRNCALCNSSLGEEAVVAMNRLWHPDHFLCNGCKKPIRQTFQVSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL65</accession>
    <name>A0A914YL65_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crossover junction endodeoxyribonuclease RusA</fullName>
            <ecNumber evidence="14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Holliday junction nuclease RusA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Holliday junction resolvase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RusA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A914YL65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18061.t1">
        <property type="protein sequence ID" value="PSU_v2.g18061.t1"/>
        <property type="gene ID" value="PSU_v2.g18061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.70">
        <property type="entry name" value="Holliday junction resolvase RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016281">
        <property type="entry name" value="Endonuclease_RusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008822">
        <property type="entry name" value="Endonuclease_RusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036614">
        <property type="entry name" value="RusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05866">
        <property type="entry name" value="RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001007">
        <property type="entry name" value="RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103084">
        <property type="entry name" value="Holliday junction resolvase RusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18061.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8542" checksum="19FC3BF701084E8F" modified="2023-02-22" version="1">MLDIGLAMPVKIRIECHMPDRRRRDLDNLQKAAFDALTKAGFWLDDAQVVDYRVVKMPVVKGGKLELTITEQGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLY2</accession>
    <name>A0A914YLY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g2038.t1">
        <property type="protein sequence ID" value="PSU_v2.g2038.t1"/>
        <property type="gene ID" value="PSU_v2.g2038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2038.t1"/>
        </source>
    </evidence>
    <sequence length="2034" mass="230895" checksum="4E82CD642C7DA8F3" modified="2023-02-22" version="1">MNPLPSGPGMYSIPPDCYGYPPPTLPETPSKTSRTPRKKTTPPKESALNRLLSTPAPMHIMQQQVPSMRPQVMQQQPPHSLSQPIYSHEEMVIQICKNVTNQQQMLGPHQSLQQAIQPQHQQYPHQASLPQQVQFQQLSLSSPQQLQHHTPQSEQLETYIPPQHQQQQPMNIMPQQNKQRASSLSHIHQQRYSNSGRDSLSNNPIMPQINSPYSNGPMPHPSTPILSNPLPANFYSSPEVPLNESPEMFQFSPNNPQLPNRLSNFNSTLIYNPNINTTATASPPKTQQGKRSYSRTNNDEIGETSKRMKENFSTQSHAVRASAISTVEQSLPPNNCIIDNPIIQPSTSSIQGYPQASGTYVSSSMNQRTPNISYASAFTQQVNPQLKVAYGLQEHNSPFAEANNFYNCTAFDSTRIKEPLVEVAPKNQASVSVSSRNLSHPSSDLMDQSNPTSSTNSSIPVSTEQIVYNLQTDESNDIDPCEEFMDPEVIHRVSQEYSMRDTIQGSKEPESKRNVEDVVLADVNERDNSQMTEIFGEPIVSNDKQIVPSQIEEPEHAVEAEKDFESSSYLSLTKETEECGFNGNHKSMSEPVTNFVETAQMTNVSEENVVQNNDQNDTIEELEVEKEVVSVPLLNETSEAKEDESDAHAEAPVEKYFADVSVEENNSLMTEVFDETKVPTVQHKNITQMEEAEVEKETELFSPLNITTEGEGKEAEQNITDFVEIENSQMTEIIEEITVPNDEHTDALESEKQQSEEKTESSPIISVMKEIEEIEEGEIVDSEEESTKSNDEILDSEFDKRKYRKRSRSVESDEPPVVEEKRHKSSTEPSIVSPKSVEDNALQQEFEKIDIIELNEAEFCVKNDEENTDNLPNEAAILLLADSPVVNPPTPTVIQNTNESDDVVQSSIHIPENEVNSKDSENKIDEASLLSEIPAIEEPMDLSENPVEEIFIANTSENHDDEIMNEVVRDVQMMDIVDDNNEDTPPSYEELLQNCEEDLSIGNDENLSRFGANAAMDAATTIVTLNVMRNEVYQLISDLSSTTSVEQSIMINIVSETVDSELAEIKNKYLNVIKVIDKSLETSTMKCGMHHGTTYEGAMYEVLIPLYTAAVKWEKQSNKKPEFYLNIGYVKKLLLSIIANFGSNDSSNIYHELFALQMFTVSKRLDIFYQLLTKSINICPFMDEYFSLTNNLFNVTQLAPVLFINDYEEFKTRDPRLANVIIAAVQQVRELSPELRSRIIFQFQLHLNNFLHKFEKSNILPEAYSFVSTLSWDAKTFGNSWDLPQGYLPIIQTINPTVEKIFKETLQKLHKSGTLEIKGWTYNLSKSIMQSNFMTKIIRNTNNLQKEVQEALFAEIIPSLLKLVLSVPHLFVAADPYHSLELIPSVFEDALPILNKAAEDIHEQMSVPFMPFATIIGALKSHQSQSTTSLLKICHNLYLTLKNAATNIPEAIQAERRRCSNKTLYEKIHREYVRRQMANYDFEKYENDANKLDLKHLHLLISKLFTTKTLETPPRIIAGIKEGVKEPVSTEKVFRARIISKCCRILKEALDSVTVEQKLKFMIDHPLLNENLKIDDILNVHQFGEDMLGCFTAFIGLLSLPDNKVLGDPKSSTFFNSIKERRNAIYYYAIKNSALIKNHKPPIPIQILNKDVPIYEILVQIFVTAEMKRILCCPDNVTSYLYLALIINDIPGISIGDASQQLFDVCGITENKVEFFATANFSKDLEAKIETMMNKELEELVKNVSSHVASPGIPRITHHQLSSCQTRINQLKCLIIEITATFWNPHKLLLGVGLTLECRKKIEDGIKELGKQLLTGFYHMGKTTVTVADLKDMIFEEMQHIQGESFMNYENSSLYGFVIYIQKIFNVESTVSSILIILYMLTITHEKQVYAQRLTLSQRIAIEPTLLKIFGLKNSELIPLGIINDMNQLMKVEELFEADYIFHASETDPHIFHMFLDRSFKKQYKELIFALESDCIEIKRRFRFHVNNQRNLYHPNVIPLKYSVDIPLINPLPKNIEKLGAKEVPEDFYYFTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM33</accession>
    <name>A0A914YM33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM33"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1838.t1">
        <property type="protein sequence ID" value="PSU_v2.g1838.t1"/>
        <property type="gene ID" value="PSU_v2.g1838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1838.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="41351" checksum="A6F9A4B51919B4EA" modified="2023-02-22" version="1">MNEQMAELKASHQAGIEEVKTKQQHEWDERLKQISADHEQIEESYNQRLQRARQEAEALRADISKQRDAAHELQNELIAEKRKFIEKENEITEFSKKYESLEKEIINLTQQLQEKEVTIVQLEKIGTDFEDKEKQNAEKMNELQSEKETLVQENSQLIKDLNDLRSDIEELNTQLETAEETTKDAQISIEEYKQQINELEKLNVHTRMAVTDLEVKIENTSDLNRTLERELTEERKEVTKNLEIIGEMHKEKADLINAKETLQLELEQLEKNFGEERNKKIDMDKKYADIEQKLNDSEDKIDRLEEAKETLTLRVKECNAQITSLKGILASFLTIIPRNIFRILIKIRIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM66</accession>
    <name>A0A914YM66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20473.t1">
        <property type="protein sequence ID" value="PSU_v2.g20473.t1"/>
        <property type="gene ID" value="PSU_v2.g20473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20473.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20931" checksum="3BB7A4B0CDE8E778" modified="2023-02-22" version="1">MHHFAPPMNRAPYNHPPQGYLSFEERRRRFEEIGTSPPTKDNIQQNRFLHDRKRRNDGEEIATTHTPKKICKSAVFLPPPPAASTTINVFPKEVINELKNKLDKRPNTVQPSSSIMAPPASCQKGLVQLMERNRKAPSYSTSSALLEYLCKSNSPSYSASTAFSSTAAVDIIFLHYQGLSGNSMSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YME8</accession>
    <name>A0A914YME8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YME8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20755.t1">
        <property type="protein sequence ID" value="PSU_v2.g20755.t1"/>
        <property type="gene ID" value="PSU_v2.g20755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20755.t1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26699" checksum="D310CD6FB6566E3F" modified="2023-02-22" version="1">MRDVLLSACFYAVCTQCNRAEDVEVEQPSFENSHSNLILFQRRLSDVMNKQIPFEHVSKEAGILVEKLTFLLNTFSKLNITLEAYVCLKAITLVHYGNPPNDDPKTSHFHAIYSKKVQIIQDQFVKALQIHLSQCENGPRLTDLFNFLPLLSSTAAILLKSKMFYVPFLICREPDRFIDSSCLKEEEESRKNLQHKIQNAITTTTTTTSTSSPTQSQPFIAANSTSSSISDVEMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN37</accession>
    <name>A0A914YN37_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase NAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YN37"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21012.t1">
        <property type="protein sequence ID" value="PSU_v2.g21012.t1"/>
        <property type="gene ID" value="PSU_v2.g21012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050136">
        <property type="entry name" value="FA_oxidation_alpha_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612:SF3">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21012.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11127" checksum="4FFB6864DB360BE6" modified="2023-02-22" version="1">MVKQVARKAKKDQYPAPYALISTWQRSGGKPIQARLDAERRAVVKLASTPTARNLIRIFFLTERLKGLGGGDSGIRHVHVVGAGVMGGDIAAWAAYGASSDPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNA4</accession>
    <name>A0A914YNA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18808.t1">
        <property type="protein sequence ID" value="PSU_v2.g18808.t1"/>
        <property type="gene ID" value="PSU_v2.g18808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18808.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18302" checksum="1EA43F9EE5781E97" modified="2023-02-22" version="1">MAETLVLRSIIDPKFSVEVDGRVIKSCSILQNVQDCTNNDGEVEVNMTQKQIEKFVHLHNHFPSADSPKDIEWTNNFFREMPENEFKEFCFKADFLDSQRFIEASGDYAVTLIDEFDIDAIQDYFNIVDDFSSEERSIMEEHALEYFTSANILTPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP22</accession>
    <name>A0A914YP22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g26.t1">
        <property type="protein sequence ID" value="PSU_v2.g26.t1"/>
        <property type="gene ID" value="PSU_v2.g26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037294972" evidence="2">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g26.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10463" checksum="37DD528AFAC0021D" modified="2023-02-22" version="1">MVLFQCILNLIPSIFISWLICLCLKRSKPATPARPVSSAPQASSGAVSDSLNQTTAPTTANQNPNAPKKVQFLSDNDPRGDSLYNIKTDMAFPKKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP25</accession>
    <name>A0A914YP25_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP25"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19107.t1">
        <property type="protein sequence ID" value="PSU_v2.g19107.t1"/>
        <property type="gene ID" value="PSU_v2.g19107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19107.t1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33391" checksum="E73A96418357A6F8" modified="2023-02-22" version="1">MRCRSSVSQIGQQIYGVASLPFKRKYIFTRKESQIAMAPPSITTSTTTLAGSSSSPPIVITREHVGCKLKYLCAGFILFNFVYGTALFIASPAFSEIVVAYAFFFALHALAAITAAFGIYDQRDFLLYPYLIMTLPFIFISFLTFAFHLTSSYYCAFLKNSSNHTFNYPQTNHSLAFYDCSFFSPNEKGWHAIKFSALAAFTFLFVGIEKMIEFYCFRRLQHHLYRIKCPRIHATHTQTLRINEIIKNVENNDSDDDMIIYERNNRNFHIRGYPNVHDPPFGTSSHRRTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPN2</accession>
    <name>A0A914YPN2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPN2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2780.t1">
        <property type="protein sequence ID" value="PSU_v2.g2780.t1"/>
        <property type="gene ID" value="PSU_v2.g2780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2780.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17927" checksum="CFC42BF0E231BBD1" modified="2023-02-22" version="1">MSDHEHDHDFNTGDSGAAVTYPKQCSAIRKNEFVMIKGRPCKVVEMSTSKTGKHGHAKVHMVAIDIFTNKKLEDICPSTHNMDVPIVKRKEFQVLSVNDDGFLSLMDLENCDTKDDLRLPDGELGDQIKTAVDKDDNGILVTVVAACGEEAILGWKNMPNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPT6</accession>
    <name>A0A914YPT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPT6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2201.t1">
        <property type="protein sequence ID" value="PSU_v2.g2201.t1"/>
        <property type="gene ID" value="PSU_v2.g2201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842:SF1">
        <property type="entry name" value="PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842">
        <property type="entry name" value="PROTEIN TOLB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037938718" evidence="3">
        <location>
            <begin position="17"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="815"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2201.t1"/>
        </source>
    </evidence>
    <sequence length="874" mass="96250" checksum="A8800258F08B1309" modified="2023-02-22" version="1">MLSFLGIIVCLTLVKGDNLLFSDEKYFSNVKQLTFGGDHSFPDFSDDGRQLVFSANGGPYGIGCDQVFRLNLDDHNEKPARLSPGFGVATRPKFWPNTKDVVFQSNFDKTSYPSDFIATATCPLSTCRPSNQQKNTTIANLCKSPTWDIFKDQNIFRVTKYGNIVQQYTNNTVYAGDAWGKKDNQMIYYSANDDNGINVYTANIKLLSTPSLITHQGINYFGGIAKDSDDRRIVYHGYRPSTAADKANLLQSLSYNLIPASRMDIYTSEFDGNDPQIVKVVQGYISHDPVFANSNGNKIVFASNYNRSMAESLFLYNINYNDGSSGDEMKGLQSLSTMQGSIATKYAAISNDFNKIVFASNRNSTNSNEFQLFIADFNVTGSSPDPFDGGHFAVASRLAQKTMLDPRNSDSKDATNEQCWQNQPVASQYDGILHYPGEKRLKNIKQLTFGGQNAEGYFSRDNKRLTIQATGNKMYGTGCDQIYQIDLCKDPAKTLPHKMSTGLGACTCSFIYPDGKQSLYAATFKAVKIGGSTTADSTCPMKQCSDANPALTTDQTLNQLCNTSYTWDIFPDYDIYLVNEYGIITQQLTNSPGYDAEGVISPDGTMIAFTSMRNGDLDIYIMDLQGKNVRQITNVTGYDGGAFFSPDSKRLIFRASRPKPGPELEKYQQLLKYNLVEPISMELFVINVDGTNMKQITNLTAANWAPYYYSDNKRIIFSSDFAATAGFGAFDLYMINDDGTGLERITWDNGQFDSFPMFNYDGTKLVWGSSRNGSEYDLNLFIADWVDSDATQSSSTLSSTATVPSTIQTSSITLTPGSSNTPSSGVVTTSGPSTTGVTHNGGQSTPSTTHTSSAPSPIFVNFSVFLILIFKALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR43</accession>
    <name>A0A914YR43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR43"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2646.t1">
        <property type="protein sequence ID" value="PSU_v2.g2646.t1"/>
        <property type="gene ID" value="PSU_v2.g2646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2646.t1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47431" checksum="1B020F4321FEC15C" modified="2023-02-22" version="1">MLKLYYKKRGESLNHHRFQDQQQRTRAQSEMAAAQTMIPSHLSHQLQQQQQQQQQQASGLLPSTIIHGNEQLLLSSSGPTREEVLSAQVQSLQEQIQNMAITNAMNRPPTGMSHAISQPSIHNDLMYPGTSPLYRPPMQHDPHQMYAMPYGYPPQQPQPPPPSIYDQQPYAMPHQQPPQQAPPSYYNSPMRYGTQTLPHHNSGMSYSMYEPQQQHLQTSISPQNHHLYGGQSFDDYQQHHLQQQQQQMIPNANNTFHLHQANASNSRLDPPLELNRNLTNWGLTYRAQTRTPRKTWAEFKSEHDLRNSDTSNSQGFSQDIIPQQPPTQKHSQAFEIPATLSLQEQQQQQQQQQHSPPRDPDLRPLQSSQSTMAMHETTTPMRRRPSTPKYENGSTEKSPAAGFTIKDSPASVVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSD0</accession>
    <name>A0A914YSD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSD0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2921.t1">
        <property type="protein sequence ID" value="PSU_v2.g2921.t1"/>
        <property type="gene ID" value="PSU_v2.g2921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2921.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10365" checksum="80FDEF91ABDC7DCB" modified="2023-02-22" version="1">MPKTVIDDNIKRGQKGKRAGLWVMPNTNTNFTCKMCYPDDECDHDMEFEANHVFMDDEKIRTIGVGLPQLRNHMKKQHWVEYLVCYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSI7</accession>
    <name>A0A914YSI7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSI7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2975.t1">
        <property type="protein sequence ID" value="PSU_v2.g2975.t1"/>
        <property type="gene ID" value="PSU_v2.g2975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2975.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10512" checksum="98FFF74A03F9A4B3" modified="2023-02-22" version="1">METTAATVERKYYMMPRTPYIFDSCSVITFGIGGDILSEQHIKMMLPQCTFLGFDPNGKYISLFEKDLSGKFIQAGVESKNGGNIILQSKHVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTK9</accession>
    <name>A0A914YTK9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTK9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4017.t1">
        <property type="protein sequence ID" value="PSU_v2.g4017.t1"/>
        <property type="gene ID" value="PSU_v2.g4017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4017.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12915" checksum="28A8398665C2D6CA" modified="2023-02-22" version="1">MVKFTIKIDKSVTEINITFKYVEVETQSIDETLTDDDNEKEKEDSKENVPDNADKRDSPSHVPDNADKRDSPGHVPDNVDKRDSPDQSVLSSIENQQHLTRDVSLIKKYKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVV2</accession>
    <name>A0A914YVV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVV2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4254.t1">
        <property type="protein sequence ID" value="PSU_v2.g4254.t1"/>
        <property type="gene ID" value="PSU_v2.g4254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052129">
        <property type="entry name" value="Spermadhesin-Link_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46908">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46908:SF4">
        <property type="entry name" value="TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="132"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="257"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="369"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="493"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4254.t1"/>
        </source>
    </evidence>
    <sequence length="565" mass="62879" checksum="62570FEB8C7E3035" modified="2023-02-22" version="1">MDFTAKNGTISSPNYPTASTIPFKCSYRIIAMSHQAIRLVFRYIGIMADINTCFSNTQKQKESNDYIELQGGHKSNEQINRRYVCARYPFVSPYGEIITSGIAPLSITYSTSGDSDYNTGFSFDYEIIDVGCGGVFFQSTGTIKSPNFPERYHPHMYCIYEIIVAWDQRVRLNFDIFDVENVANQDDCGFDNVQVYDGIYVNEDEHGELLGRFCGMSKPPALLSKGNKMSVVFLSDRSVNGAGFSATYRGVEAADDCDQTFTNLEGIIEFNSSVHPRATQCNYIVMLPKMHRIMLTFENLTLPCTQGSLIPRNGMSFDSPAFPGISNLCDSKILPTLITQGNRAFLQFSTTAPASTYFRLRYEQFAAGCGGKITGISGFISAPQYPLKDSRSLNCDWAISVGEGNRVKLSFQFIDNLDSADTRGICNSFGANYIDVSDGPYADYNLIKRFCTKQVSTDAIISEGNQLSVKYVQHGGSYHGALFGFVAHFDTFCKDIILTEHHGSIQSPGFPGPIDDNTHLSCKWTIQTTPGSRISLQFHSFDLKSRPTGMICSNYLMVRFFNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW65</accession>
    <name>A0A914YW65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Groucho/TLE N-terminal Q-rich domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YW65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4808.t1">
        <property type="protein sequence ID" value="PSU_v2.g4808.t1"/>
        <property type="gene ID" value="PSU_v2.g4808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF21">
        <property type="entry name" value="PROTEIN GROUCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="9">
        <location>
            <begin position="16"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="473"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="515"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4808.t1"/>
        </source>
    </evidence>
    <sequence length="575" mass="62222" checksum="43AF616CEA4AB5A2" modified="2023-02-22" version="1">MYQNRHNAHGGNNTKTVKEHLDRVFEEYSKLSNENQQLRTEMDKLRGENEQILRHQVGGSEQIYNLNCEVLRNQEIAKRLAGAINQFIPMLPPDQQASAIAITERAKNVSPQEVMIQQSQQQFGMLPGLFAGPGGMHPLMHMMAGMKPEDAMAAMMAGQKHPGMMMPPHPNMNSMLAAAAAAASGQMPPSSSAAVAAAAAAAAASQHSGMSIDEIAGRLNNRPPRSGSGTPSKKPKIEIQSDPDQELEIDVQNDDAPTTAHTNGTTTNSRKDGRESAQSMSSRDSATPKSVRNNNSSSAGAGAGGAGIIPPTPDMQFLMQQFANGNRSIDPRTLMYNNNNSNSQSTETNSCYSYLCKDGNTVPATFPPDAFSSSGIPETITKSFELCPDEVVCAVTFAPSNDKVYTGGKGCVKLWDISSAEAAAKPISYIKCLEDNYIRSCKLLNEQSWLLVGGEAQNIVIYDTTANQIVQELDTESQACYALAVSNDSNMCFSCCADGKVILWDIRSKEKVASLSGHQDGASCIDISSDGTTLWTGGLDSTVRSWDIRERREIDKYELQSQVSVFLKEIEILIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXA3</accession>
    <name>A0A914YXA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2718.t1">
        <property type="protein sequence ID" value="PSU_v2.g2718.t1"/>
        <property type="gene ID" value="PSU_v2.g2718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="78"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2718.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28560" checksum="9374E2C3747C5DFA" modified="2023-02-22" version="1">MNDSNETNPYCVLTKRSDFSVNWVSDRISKGCDCYELAQINIGRVQLYCVPFPFVHDIFVQFFYILLFSSLILCSIAGNLTVVWIVLRHERMRTVTNYYLLNLAISDLAITVLNTGFSGTYNLYYNWVFSDVHCAINNLMGITPICASVFTMIVMSVDRYLAIVYPLRRRPGRGATVTIIICIWVLALICGLPALAATKIETHFFVDPEKNTVFEDHLCLADKFPDGNSQTSTIFSMFVITVIFLLKYLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYD0</accession>
    <name>A0A914YYD0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYD0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5104.t1">
        <property type="protein sequence ID" value="PSU_v2.g5104.t1"/>
        <property type="gene ID" value="PSU_v2.g5104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5104.t1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44986" checksum="456D6DB6E269982B" modified="2023-02-22" version="1">MNFDALKSHGHCDPPRLCAHPPRNCNRPQLGSPPPVKKKKRDNKPDGSLHEVALNDREAWLNNTLSLGERIDLEEGSPVSFFDDDNKLIQGTLIFKGSEDELKTYLEQIPTTNPIEESTALARLSAAEDLIATLTRALTETKTSFTNLERRVKKLEGKKKKGGHKAVETNSTWQTMIAGIPQLISSLPDITTELMAKILAFRGRSSAIPSQSRQDLREMLYRNQAFFILHYYDANTCAGAVYYLLFGPTVAKQAFLPTPFYSQGPRAIAGQRKPCLSFHATSAFFLALDLVIANVFTPDHRLTFITKGRDYINRNVNTMKKHGRTKAKKFDVKAYDDGFGFLEDESLVDDYVNERDTVATDPAVIYNWAIQLGLNYEQQVAPVANGDDGGDDDFHESSEHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZE7</accession>
    <name>A0A914YZE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZE7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5472.t1">
        <property type="protein sequence ID" value="PSU_v2.g5472.t1"/>
        <property type="gene ID" value="PSU_v2.g5472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5472.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9406" checksum="9F2FB6CC4D06B873" modified="2023-02-22" version="1">MTVAGYLLCSTNLRIKDARGFNLLGLPIGPPSKGWLTPSKLKDRAERVFQLVPEKMKNLVIVNSALSDFDMIQTCLSHHFWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0F6</accession>
    <name>A0A914Z0F6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0F6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3754.t1">
        <property type="protein sequence ID" value="PSU_v2.g3754.t1"/>
        <property type="gene ID" value="PSU_v2.g3754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3754.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28730" checksum="308143E2534E0855" modified="2023-02-22" version="1">MMPSTFQQEPLNYYNHVPYQPNQRGSIIIIHHSNHYESMYPAFKPTLNFSQPPMGTFPAYFFNNSYAKPSFNQMQAPFVAPLFGPYNFGNSMKFGVAQPPSTHFPLAQIDSVYCMDFMDDESPHASISVTTALVHTESTEKTVIDSELSSGTENYYFEEYDPTPTPSISFVSSSSSSDLKFTTAPPSPAPKDEAAENHLLEAAENRLLEAARFYLQEVAEHDLQEAAQNRLIEAAESYLQEAAENGLQDASKNPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z226</accession>
    <name>A0A914Z226_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z226"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6758.t1">
        <property type="protein sequence ID" value="PSU_v2.g6758.t1"/>
        <property type="gene ID" value="PSU_v2.g6758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6758.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16852" checksum="90755DC92E6690D3" modified="2023-02-22" version="1">MSSGKRKTGTKTHTAMELLDSKFNATNCEATDIWSFGVTIWEIFNETEQIPYKDILKRVTEVTLLDYFYAKNHLETTYWPPKETSDALVTAESYMKRCLVHRQEFRPSFDKLWHLFETMLPEGQRLKCNDEKCEKSFSDFDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z267</accession>
    <name>A0A914Z267_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z267"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6804.t1">
        <property type="protein sequence ID" value="PSU_v2.g6804.t1"/>
        <property type="gene ID" value="PSU_v2.g6804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6804.t1"/>
        </source>
    </evidence>
    <sequence length="557" mass="62107" checksum="1A21E91DF5AABD2A" modified="2023-02-22" version="1">MSNETTASLKTYNLLSQTRVDHAGLPMNGNITDCFICCQPSDVFGVGKCFHPICMECCIVMRVLDISNTCPQCRFPIEMLYFVSAPYSWDNFTFPSGEVHHPDSKKYGLKFTSDYTVKCYDSYVKHSCSICAKINSEKVYPTFAALKNHMTNVHQRNFCSICDQHLQSLSKNRVAFTKTEMENHLKGTNNEASGQKGHPMCWICSGRFFDDDFLNRHLKSEHFFCQLCEDFGSIVSFGTTPELYAHYALEHFPCDSRDCQHMGIVFSTEEELELHKADEHGFSLRNLTALFTGRSNQSTPRDVLSTPQRESQPLASEVQPSSAARNASIQSIRTSLLNIARTRPSASSQVSNNPSIHTAILNLSQREAHHSPRPPTIVRHAPSNQSVQTAVLNLSQRESQPSSSSRHPPTIRNAPSNQSVHTAVFNASQREAQPFSFQPTPIVRNVPSNQSVQAAIPSNSQISSTSRTSTPQTRASEISIASSRTVTASPARNMRTPPLQLVQSSPQRSTSSNDRLMPSTYVSSVQRQRRQVFVCCIAAVFLVIIFLLIIKAMAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z293</accession>
    <name>A0A914Z293_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z293"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6017.t1">
        <property type="protein sequence ID" value="PSU_v2.g6017.t1"/>
        <property type="gene ID" value="PSU_v2.g6017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037340493" evidence="1">
        <location>
            <begin position="24"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="448"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6017.t1"/>
        </source>
    </evidence>
    <sequence length="783" mass="88641" checksum="DBE10C2BE27400B0" modified="2023-02-22" version="1">MLLRFRVQTAFIILCFYISTVSSCMPGYEGEREKLRQYLGIEWVPNGLKEMDAQKHKAVRHPEELNCDFTDPSKCRWMNNKNLDTLNFHLFEKQDHTVFPALQVRPGPSKLEPGDKLIFVGDKKKKDQSALITSWPIRCQNTTGKLTFNFWVFNGANVEVIILEENMDTGVLQQSGEKIYVDCGTVTMNTECTVDIPPRELPFRIGIRAYDINNPEGSFVMVDNIYYYASFCKVSIEFGPNFKTENLMTGADGMPVENSHHLNCDDFDKTCRWRNGGHGKRIWKKAITAPSEQLMFNETGTYTVPQVPFAFMYIEEDSKKDDFMALISDPITCQSATSSTISFRLWATKGVQMSICTMNFEMKPIECQKISMGRSPAPSIHHFEQTNDFMYGFRVDSANPDFDNFVAIDDITYEATMCNEAINALDFGSNFYSTAMLSTLLNRPVQSSKDLECSFSKRALDCFWANLEGEKGQWEIGVGTIDKTKFASLTRRLTYPDTEFAVARLNQRNLSAVLASETIRCMSDKAVLSFRYWHTGAAVLSICIIKSISFDVIDCQSIGSVSNEHVYVDIPQMDETIRIALRADSLMGEGIIAIDDLKMEGKFCPTVAFSPNSGFGSKKSRRPAERHIQGSPDSNVCRLLSCNFDKENLCLYESKRVANSLSMFSVHNGVAHTMLFERSRVSMLESTSFHLNAAARLHFDYSIVKGFAQIFICEDSVVRELDTCYKVTASKQTEKGEFVHDFIEILPSDIKLYIIVKLEEGSRKASVRIDNISLTDIENHPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2K0</accession>
    <name>A0A914Z2K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein Asterix</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asterix family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2K0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6936.t1">
        <property type="protein sequence ID" value="PSU_v2.g6936.t1"/>
        <property type="gene ID" value="PSU_v2.g6936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193">
        <property type="entry name" value="CGI-140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT ASTERIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6936.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11942" checksum="C1A8C23110F131B0" modified="2023-02-22" version="1">MMQSSNDPRRPAKIVRYKPIDPQTSPVSSEDSLPEYMNVLGMLFSMCGLMMRLKWCSFAALLASCISFANTRVTDDTKQIVSSFMLSISAVVMSYLQNPSPIVPPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3B4</accession>
    <name>A0A914Z3B4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3B4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7188.t1">
        <property type="protein sequence ID" value="PSU_v2.g7188.t1"/>
        <property type="gene ID" value="PSU_v2.g7188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7188.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27999" checksum="D170B1D638B15EDE" modified="2023-02-22" version="1">MPWRFTTPSPPPLPITVISKKDNLEEILQAIDTTSYKINNGSLSSSSQNDTEVVVIENGSETFRIIDDEHVFQQNNETFSTTFTTAERVTTPSPLPPTSTPGSPSKPFHRRLPISTTPKCERLSEKQKYAKLESIGGRNQQFMANTPEEASKNFPHLIPKTEIDSPKIKSNSRIMMSDAAGQRAYLETEYCDETCEEIRIKLHEAIDLRKKPMRNFMRLYDSGPAEVQEGKPENWKSGCYLVSVKNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4H1</accession>
    <name>A0A914Z4H1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine-hydroxylase NDUFAF5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Putative methyltransferase NDUFAF5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4H1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7590.t1">
        <property type="protein sequence ID" value="PSU_v2.g7590.t1"/>
        <property type="gene ID" value="PSU_v2.g7590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="6">
        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7590.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20124" checksum="DDE6E6AF9342F930" modified="2023-02-22" version="1">MIFDRKTKLKQRNWAAAHPDFDVCQYVKDEIGYRVADKVFDLTKFNDIVLDLGCGGGHIGQHLIKENVGVLLQCDMSEGMIRKSKGAPEDELPTLRVIGDEEKVPFKSQSIDLIVTSLSAHWINDLPGWFQRCYNILRPDGAIIGALLAGDTLYQLRVALQLAENERLGGMGTHISPFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4W5</accession>
    <name>A0A914Z4W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4W5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7020.t1">
        <property type="protein sequence ID" value="PSU_v2.g7020.t1"/>
        <property type="gene ID" value="PSU_v2.g7020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7020.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15416" checksum="E44AB4D6781BB87A" modified="2023-02-22" version="1">MYDKSGKNYRCLACVGKFNLSVSAKVFTNDEGNLAVKLGSNEHKCKPQEIRILQKSNFKTEMIIEKNGKEVKMLTITDPIYYNKVFTYYFHTYRQCYYCKNCSKTKTYIKANLRVENGEEYIELSADKHVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5B0</accession>
    <name>A0A914Z5B0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BMP family ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5B0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7145.t1">
        <property type="protein sequence ID" value="PSU_v2.g7145.t1"/>
        <property type="gene ID" value="PSU_v2.g7145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036954817" evidence="1">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7145.t1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11851" checksum="4C702FF37F0DF026" modified="2023-02-22" version="1">MTGNFMRKALLAAAIASPLAALPVSAQANDQEPLKIGFVYVSPIGEAGWTWQQDIGRREMEEALKGRVVTQQQADLHHLVWLHEPDAESGQAVSGREVRALYRLQDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5C5</accession>
    <name>A0A914Z5C5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z5C5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7885.t1">
        <property type="protein sequence ID" value="PSU_v2.g7885.t1"/>
        <property type="gene ID" value="PSU_v2.g7885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="581"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="821"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7885.t1"/>
        </source>
    </evidence>
    <sequence length="882" mass="101026" checksum="96259E29410951B0" modified="2023-02-22" version="1">MKNWIKAFNLKAEEQLHEKCYQVDTVDRLHNLLDGYSDVFKKEYGTCKVKVSLKLKENGEPKFFKPRVIPYAYREKVSNQLREREKAGILTKVQYADWATPLVVVPKPDGDVRMCGDYKLTVNPVLDVNQHPLPRVEDIFQELNGCKYFTKLDMFDAYHQIPLDDESKQLTTISTHEGLFQYNFMPFGIASNPAMFQELMEKALHGIPKVAIFQDDVTVGGETIKDNLDRLEQVLKRFYENGFRLKKEKCEFLKTHIELLGHELDGDGIRPSSKKLNAFKNMPVPVNVKQLEAFVGFVNYYGKFVKDFAILAAPLNDLRKKEAKWVWGDIHKKAFEEIKQRLLKGDLLTHYDPNKELVLATDASEYGIGAVIYHREADGTEKVIANASRKLTSAERNYAQIEKEALGIIFGVKKRTAEFANADALSRLPDPLEDPSAEMLDGEEEFERLYVIDETKSPLNLDNIVEATKTDKLLQMIMKWTKDGYPNEAPKDYKDWWDRKENLSCRNGYLLFKDKVIIPESLQLKVLKILHEAHVGRNRMLCIAKENFWFPKMNAAITQIASSCEICNGCFKGQKERLHAWEEAEAFWDRIHIDHAQFHNKQWFIVVDSKTNWIEVMPCKSVDSATTIKLLKSLFARYGICKQIHSDNGTGFTSNEFKEFCDSRGILHTKSPAFHPQSNGYAERAVRTFKEFSEKQFQAGHNLEDAVANALLIHRASTSDSTKLSPAEAAFGLKLRTRMSIHKVHAIMQGKEKQEFGVNDKVWVRFYSSGPRWRPGHISKIVSKTTFLVDSNGEILFRHRDQLRRASESLFIEKKSCHEKSLVEPTTTTTTTTAVEENNQDKTNDSNNSTSKSNNRVKSRTNLSSTVLGTRKSARAPVPKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5K6</accession>
    <name>A0A914Z5K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5K6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g763.t1">
        <property type="protein sequence ID" value="PSU_v2.g763.t1"/>
        <property type="gene ID" value="PSU_v2.g763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g763.t1"/>
        </source>
    </evidence>
    <sequence length="517" mass="58769" checksum="6227203F44B1FC1D" modified="2023-02-22" version="1">MVNPPEYSLENLKIEYEKAENKWKKESILLLMKLQGFDEKEADILKFDNAFANKNAVELASLIEALHYSAPTNGIKERLKAITDIIFDGKNDEFVRVYIHEIPAIREVMPQNPELYRGMINASILATLNPKLFNKDILSPFGLPFLKLPSEQLHLGLSCLSLKFNSSQSTFDETKILKLFETLILNNNDDKDVIISALLYGLSIWKNMLGDNLLLLLPANVYNMQIKTFQNFNGFPLKFDVDLIHRGIGKKNSECQQLINSLKITILLLKKHSKIIAHAKFFHDYMGIEHSSIWNYLLTCLLLFNEYQLATTLLAMQTDVPLSNLLLLQIEFAMGRIPEALSVANEIILSSSVSDFHNSAFREAVLIENCYLSLSKGAVIQYTALIQSHICFLILVRTLSTKPQLRDFALGNIMVMSQVLQRFGQGEVITRLIAGIIKTNNSFIFPNFDQYICQSHVFTSFFNEATIQWQISESHRSLEGAIQGRLLSAQPSDLDPVTVAKNFIRNNSVLFNEFKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5T8</accession>
    <name>A0A914Z5T8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5T8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7311.t1">
        <property type="protein sequence ID" value="PSU_v2.g7311.t1"/>
        <property type="gene ID" value="PSU_v2.g7311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7311.t1"/>
        </source>
    </evidence>
    <sequence length="676" mass="75457" checksum="1933F9EFBDCA1EB4" modified="2023-02-22" version="1">MELTKVPIVTRKGENTWSTPRPTTQRGEEYKTWGTPKILPITKPTPSHPDISRTTPVPRTTFIAKFSVLPTKTEKQPAKKPEVKTTSTTSEEIPITKLKKFFTRRPTTSTESTTEAPTESVSTKKKQLFTRRPSTTSSSTEKSKEVTKSRERTTSKSVETITEEFTTDFTRKSFKKPKTTATTASASEETVAASTKKKQQFTRRPSTTSASSEETISSTSRKQFTRRPTSKSTEAASTETSTETTKITRRKFTRKPTSTESTTESSTTEASTRRKFTRRPKPSSTESASTESSTEVSTRKKFTRKPTTTTTSSSEEHSFKTKGFFTKRPTTSSSSISTESEATTTKRKFTRKPKPTTTTEEVTTMLPLKDRLRPILTTREPTPTMPRRFRVFTNPAPAEPPTEELNPQQEIENQRKLKEKLSFNAEFNQEFSSKHKFAQRFGIQRIIPSSFATTPQASIIVTPVTASPIVVANTNNIGNGVEQTVRSNAIILQAQKNPFFLPSNVTSNPSLFSSSSSSTPAPQVLHRWSSSWSSWSSWDANGQKVTGSTKTFSTSETSEATTTPTTSQSNSKQISRTRTEQSSTISSSKHSNRAPIKPHIIHHGRHRYRGPTYNCRVLTPNEDGRPSSNNDPTCKLKFPGFPADDSCRCRYDVEARDDQGCATGFLYTCKRISQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6C1</accession>
    <name>A0A914Z6C1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6C1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7457.t1">
        <property type="protein sequence ID" value="PSU_v2.g7457.t1"/>
        <property type="gene ID" value="PSU_v2.g7457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11397">
        <property type="entry name" value="bHLHzip_MITF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7457.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26340" checksum="2FD49678F6AA5A80" modified="2023-02-22" version="1">MGSNHIGSGSRPIPSGGSSGNSLQSGSPNGPMGIPIANSASFRQIVSSSAPTSSFDMEAFVRGGRGSSNSSNQSTNPTVDSDFYRDRRKKDIHNMIERRRRYNINDRIKELGLMLPKSTAEEMKLNKGTILKASCDYIRQLQQDRDVMLKQQHERQQLEEATKLYAKRVRELEDALQKNGLNIPEGTNPPPLPNKTSSENSSNNRPIKQEPFEEPLSPSQTPTGSYVKICQFFILKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7Z6</accession>
    <name>A0A914Z7Z6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7Z6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8807.t1">
        <property type="protein sequence ID" value="PSU_v2.g8807.t1"/>
        <property type="gene ID" value="PSU_v2.g8807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8807.t1"/>
        </source>
    </evidence>
    <sequence length="435" mass="50087" checksum="3CBD532940A57EE5" modified="2023-02-22" version="1">MGNKPIVSFNSFELIQEAFVKNADAFAGRPNTQLKVLRGGIYGIVMTDGELWHTHRKFALHVLKKFGMGKNLMQERVINEVRWMIDEMKEEELKNGENEMSVHKKIDVAVGSIINLLIFGYAFHEQYLEEFFKIKNFMRDFIKVSGNPLFRILSADTSGILQRLPGFKTAYNEGKRLGDELRTFFNYQIQERRQKIDFSQDSEPTDYVEAYLREQQKNEKAGEDLEMFSNEQLFGCVFDMWLAAQETTSNTLSWMVLYMMTNPESQNLLHQELDKIIGSDRIITIEDKMNLPYVNAVVAETQRCCNLMPNNVPHRLITDINFHGYSLKADTIVVPQISSVLYDETIFPEPLKFKPERFIDANGKFISKPELIPFSIGKRACLGEGLARLELYLITANLLNQFELSIIPSKPPNMTPIIGGVKISQPFLTHVKQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8H6</accession>
    <name>A0A914Z8H6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8H6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8977.t1">
        <property type="protein sequence ID" value="PSU_v2.g8977.t1"/>
        <property type="gene ID" value="PSU_v2.g8977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8977.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24903" checksum="19DD079F02C8F6DF" modified="2023-02-22" version="1">MCIDRSGDKLFALTSSEKILEYDTGLGENPLFAYKYPHQRATKVNLCHSPISDHLLVGNNAGSSYIYDLQKETYYGDLLHNNQNPVVKDHVHPRFKLPAPSIPEIFSIVDWSCNGRYMINVTPDNTVIWDNEWLEDTEFTPIKCDSKDSTINTEINGRPINLERMLYVEEYAQKIKDQKWNYTIARRIGLKETDMKIPLNVLKEEEELERYDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8V0</accession>
    <name>A0A914Z8V0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8V0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6672.t1">
        <property type="protein sequence ID" value="PSU_v2.g6672.t1"/>
        <property type="gene ID" value="PSU_v2.g6672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6672.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16318" checksum="2D8A49E5CB36FCC1" modified="2023-02-22" version="1">MAVMEEKYEIVSFLIKSGASLDISTTDKLSKVPSKRTPLMEAVSLGSSALIRLLISNGANPFLKDAEYKKASFYFDEEEFEKNFAVAEFDDLKEAMELLKNAETEREVREGENDQQDDDVEESNLRKRLNEGTLNVSKRTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z980</accession>
    <name>A0A914Z980_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z980"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8370.t1">
        <property type="protein sequence ID" value="PSU_v2.g8370.t1"/>
        <property type="gene ID" value="PSU_v2.g8370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8370.t1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47607" checksum="3D2983C229432CA9" modified="2023-02-22" version="1">MYPDLDQSEVVFVHKLASGEPTARSRALKKLHAFLKQRSEDSSLNEETFKRLSKGLHYAMWMQDKPILQQELAENIASLIDDFGTHDEGALFVKIFFQALSTQWHLVDRWRMDKFLMMARVMIRKTFDVMSKNKWSKDITATYLSVFKETLINSQSNIVQSLKTHFASLYLDELSKTEKVTKAVSEKFIEPYLEILQENRATDFFFKSICDEIFQTLIYTASEEIRRGDLEDVDSEEEDVDDIVQLLRIDNPIPCDFDKLGDRLFEIGAQPTVNSKRRQRLYALSKKFKAIVQGKNPQPEPMEVSDKPAISKSKMHKAAERLLGMQQKLHMDRQKFKMEMKEMKKKQNEERIADLLTSIITSKGTKKIKSSNKFKPNAIKKKGHLKTSSTASRRHAGSSSKGKTSKFSSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA47</accession>
    <name>A0A914ZA47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA47"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8798.t1">
        <property type="protein sequence ID" value="PSU_v2.g8798.t1"/>
        <property type="gene ID" value="PSU_v2.g8798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8798.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8328" checksum="3DAB63395A54A299" modified="2023-02-22" version="1">MARGNQRDLARLKNAKKQQEMKRAQGASAKDGNAGVSTDKRLERDAEVMRQKQEKALEKKKLKKLQPPLLQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAM2</accession>
    <name>A0A914ZAM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8818.t1">
        <property type="protein sequence ID" value="PSU_v2.g8818.t1"/>
        <property type="gene ID" value="PSU_v2.g8818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8818.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9216" checksum="E27F06651E0ED1B9" modified="2023-02-22" version="1">MDIEKTVVKFTDEMDVGTICDTLRIQDTKTKFNRIRSIKTCRPKIENGIIHLFLKSAEPGCHVEVVNAEIKYPEIPTTTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAR3</accession>
    <name>A0A914ZAR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING-CH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g734.t1">
        <property type="protein sequence ID" value="PSU_v2.g734.t1"/>
        <property type="gene ID" value="PSU_v2.g734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g734.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22984" checksum="C4E8F55CB7C4FC04" modified="2023-02-22" version="1">MAANTNIDAVSKDLEEVSLKTPNSTWSDYDCNIAEKQCRFCFGDEESDRKSGLPSSWMTPCKCDGSIKWVHERCFKQWLNLAPFPQQSACSTCGFIYRKSWKMKSLSEWSCPPLRITFWDIIEIGLDFYSTFKLFRGMWQMLEGKKAVFGQICYFIFWKTFIFTDRRILYYKSIAAAMATSFFEPQVRDVDDEKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB98</accession>
    <name>A0A914ZB98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB98"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9032.t1">
        <property type="protein sequence ID" value="PSU_v2.g9032.t1"/>
        <property type="gene ID" value="PSU_v2.g9032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9032.t1"/>
        </source>
    </evidence>
    <sequence length="255" mass="27967" checksum="807C8F0EBC217550" modified="2023-02-22" version="1">MKRESNESVENAKRESTSSNSASASTPSGMNGVSTSETINGHNGGPQSNDSKTSSNESKTPRLQEQNGHPPPPPPPQQQQQQQPQPSQSAASTSSPSENRGFKLTQAPTGNAIDSVSLNVLQQKTTTPAHKKKEIYRFTGKDPFYACAWSNKYMGDSFRIAVCTCLDDTDNFDKNRISILEYDEYKNELIERCNFEHGFPATSMMMNPSKSLDSPEILATATNGLKLFRYDRTSQSATLEATMISVSQLILSKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD05</accession>
    <name>A0A914ZD05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L37a</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZD05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9564.t1">
        <property type="protein sequence ID" value="PSU_v2.g9564.t1"/>
        <property type="gene ID" value="PSU_v2.g9564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9564.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10205" checksum="DF3829237295E0CD" modified="2023-02-22" version="1">MAKRTKKVGITGKYGTRYGASLRKQVKKMEVSQHSKYTCAFCGKEAMKRTCVGIWKCGKCSKIVAGGAYVYSTTTAATVRSTIRRLRETKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDP6</accession>
    <name>A0A914ZDP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDP6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9802.t1">
        <property type="protein sequence ID" value="PSU_v2.g9802.t1"/>
        <property type="gene ID" value="PSU_v2.g9802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9802.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19892" checksum="32C935302CB60FFB" modified="2023-02-22" version="1">MTTTFYARYFSRPIQENDYDIAIKKLKNILQLDEDENDWEDISSDEEDDDEPEEQNDEYVVEKVLAEKVDGGKLKFLVKWVGYEDEEDQTWEPLDNFFTKGSKMAIFLFYKRKWKKQMKLEKKDHGDVGASSASADVQGKKNGKDKEKKKKASFFYYKYLRKYPEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE19</accession>
    <name>A0A914ZE19_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L13a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZE19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8523.t1">
        <property type="protein sequence ID" value="PSU_v2.g8523.t1"/>
        <property type="gene ID" value="PSU_v2.g8523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8523.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22955" checksum="D77CBF599B551476" modified="2023-02-22" version="1">MSFSAKPIVIDGKGHLLGRLASVVAKQLLQGQKIVIVRCEEINISGNFHRSKLKYLSFLRKRCNVKPTRGPFHFRAPHKIFWRTVRGMLPHKTARGSAAIKRLRSFDGIPTPYDKSARFCQPNCMRHIALKPRRKYCTVGRLAHEVGWQYQGIVAKLEAKRKVKGAAHFEKKKSATKVEAKAKINVAKKIEAYDKILASYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEA4</accession>
    <name>A0A914ZEA4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZEA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8598.t1">
        <property type="protein sequence ID" value="PSU_v2.g8598.t1"/>
        <property type="gene ID" value="PSU_v2.g8598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="157"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="389"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8598.t1"/>
        </source>
    </evidence>
    <sequence length="500" mass="55514" checksum="8EFD8387057DD577" modified="2023-02-22" version="1">MASAAIDVNQGITNHKTATIRNYTTQPRLTYKTVTGVNGPLVILGDVKYPQYAEIVQLTLQDGTKRSGQVLEVTKNKAVVQVFEGTSGIDAKNTICEFTGDILRSPVSEDMLGRIFNGSGKPIDKGPPVLAEDYLDINGQPINPWSRIYPEEMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNEIAAQIVRQGGLVKLPDRPHHEGDDNFAIVFAAMGVNMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALTAAEFLAYQCQKHVLVVLTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRDGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTREDHSDVSNQLYACYAIGKDVQAMKAVVGEEALSPDDLLYLEFLIKFEKNFISQGNYENRTVFDSLDIGWQLLRIFPREMLKRIPAKTLDKYYPRGGAATTKSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQB4</accession>
    <name>A0A914XQB4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="1">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914XQB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10209.t1">
        <property type="protein sequence ID" value="PSU_v2.g10209.t1"/>
        <property type="gene ID" value="PSU_v2.g10209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Methyltransferase TRM13" evidence="2">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10209.t1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26455" checksum="28394A5C4D7B5327" modified="2023-02-22" version="1">MKNKLLENDPSKAVFELGVGRGQLAFYMASQAPETKYILVDYSGIKHKADNKVKNKNAVDIKRIRCPIEHVDASKIPSLTSSTSVSAVCKHFCGSATDYGINCITNAMFNNVPINGFCLAPCCHHRITISQYVGHDYLKAIKIDSPQLISSLRLIASWATCGPPVSETAFVEAIDDGENFKFWSYEKKLILGRKAKALIEFGRVLYLRKVCGFDCRLLEYIDVNVSPENLMIVGVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSI2</accession>
    <name>A0A914XSI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10939.t1">
        <property type="protein sequence ID" value="PSU_v2.g10939.t1"/>
        <property type="gene ID" value="PSU_v2.g10939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10939.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20183" checksum="663243DDA804413E" modified="2023-02-22" version="1">MSLGFDDNEILSQSIGENEDYYFISITNNTNLTFDLSVITEYNAFQGYIINDDWNVGCPLESISKIDPYSFSKNPNEILYLRSTFLLDDQFGDIPSKCIWNFVAPDDDYQFKLVVLNFPSDLNTTLLLSYGDNVNQNLTVAHFPGNRKKGGNFPGNSREMPGKFPAISRNFDFGNLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTM0</accession>
    <name>A0A914XTM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTM0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11306.t1">
        <property type="protein sequence ID" value="PSU_v2.g11306.t1"/>
        <property type="gene ID" value="PSU_v2.g11306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11306.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15486" checksum="EB6462F5B3746342" modified="2023-02-22" version="1">MRLHRAFSDMNNPDDDIPDEAAGMLAHEAQNAGHLANGSSGHTLAEQARAHSSSPRRIPLFERASARWWNPQFASAILETQYWKCSFPLLRDRFRSGLIYIMLTCGLWMLYVLIFDEAAYHHWVKSSYQSTPLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU59</accession>
    <name>A0A914XU59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XU59"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10785.t1">
        <property type="protein sequence ID" value="PSU_v2.g10785.t1"/>
        <property type="gene ID" value="PSU_v2.g10785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000518">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10785.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24344" checksum="F1A79F0B2193F48E" modified="2023-02-22" version="1">MAFFNSPYSVLNHDDIECTKKIGEGAFGEVSLGRLNMKGEKIEVAIKLAKLESLTKEQIKEIMLEARLMRMFDHPNVVKLYGVAAGQEPLMLVMELADKGALDSYLQKNTLSNEKKIEMCAQASYGVEYLHHMNVLHCDIAARNCLYGNGKVKISDFGLTREGQTYEMLPTKRVPIRWLAPETMVYYIYNQKTDIYSFGILCWEIWHNGNCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWH5</accession>
    <name>A0A914XWH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">5'-nucleotidase domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWH5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12291.t1">
        <property type="protein sequence ID" value="PSU_v2.g12291.t1"/>
        <property type="gene ID" value="PSU_v2.g12291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF12">
        <property type="entry name" value="FI20020P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12291.t1"/>
        </source>
    </evidence>
    <sequence length="511" mass="59683" checksum="A03A4D1349D1DDF5" modified="2023-02-22" version="1">MIKTKIFFLNIFRSFSSKSGEDIPTKLRAVYVEAKAAVNHEPYTHRVNPRGVFTNYELNLRNVGVYGFDYDYTLAIYTKNLNNLVYTCAMNRMVKDLKYPKALLEITSDLSFAIRGLHYDIEHCVLLKVDAYNQIQRGTVYRGKRKLSDEEVKDIYGDFSVPDNKGKNLPQLIDLFSLPWAGLLSRIVQYFDDRKLAFDPVLLYEDVADCVQRVHASGEMYQCVMDDLPHYVHKNEGLSDYLHMLRDHGKELFIITNSPFQFINSGMTFMLGEDWRKIFKYIVVSARKPTFFQGKAAFRRYNEETNGLDYEKVTHLYPDQIYSGGNMKDFSEKAEFKSRGVLYFGDHIYTDLADPILQLGWHTAAIVPELAREIRVQNLDTYHYIIVWLETLTQLIETYQKYGDRDPLCCNVITEWIHERAKLRDNAKAMFNEQFGSMFRTHHSSTYFYRHLNRLADIYTSRLPNMSTYGPEHTFFPRRNALPHESKTSVVEIADEIVTKTESVHELSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX96</accession>
    <name>A0A914XX96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11155.t1">
        <property type="protein sequence ID" value="PSU_v2.g11155.t1"/>
        <property type="gene ID" value="PSU_v2.g11155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024:SF12">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="255"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11155.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38699" checksum="20E51DD2798C657B" modified="2023-02-22" version="1">MKNNNSVIHEIDFIDKMISNWTWGDDGVNVAFLSYGFLGQFSMNKFYKDLTSAQQVLASLRQLANFGILSPTTLTAAVKFVDEVYTNTYPHRPGVEPRFICFTATNDTVDIANAAIYFKNLYEKNYETLINVIFSDPQLFKNLESLKVINMEDFAPQYYENITETIWNTLCVHDIRFTPLPCTTTTTTTSIPTVTTAKTTTFAPIPTTTTTTKLPMTTTTKNLPLTTTTSSGGIGPGGNSGEGECRCVSQHLWLDIVIVMDASQSIRQEGLSELQAHILTLFGAYMTIDPLQSQSVRVAIVSTAERAQIEARFDQIKSLEELQYYLYGVTWKKEQDTINIEQFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXI1</accession>
    <name>A0A914XXI1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXI1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11918.t1">
        <property type="protein sequence ID" value="PSU_v2.g11918.t1"/>
        <property type="gene ID" value="PSU_v2.g11918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11918.t1"/>
        </source>
    </evidence>
    <sequence length="689" mass="78366" checksum="8DE594E8D1625853" modified="2023-02-22" version="1">MMVSEVAVAEMAQPRAPTEERSNSIESDISANHNKAETSSIVVEKALPTVSKEVECIDIDDDDVQAISPPPAKKAKIEENGSSNNNKLNGTSTDVKKSPKAIASYDDLLDKVYDHVHSQVESKKDLGRKVMDIMLAAINQEVLNDPHSVRKLIIDKQLVLPNTITHPPSQYVHLLIEHDPEHLLTRIIQKLYGEEKPKETEQERQEKLRFRREFAAPTMTRVVAQIGQELVQEYTYGDIVHARNLPDMPKDIEGYKRVAEQLKPVWQSLKEKNAPYKSKYHVCRVCRFKTDSLIAFSKHQWTLHYDGKKYSCTMCPEFNNNVARIRKHYMDKHEIVPTPVEEPSNRLDCPICEEDFKFKGELHNHLKDCKRQALNQRRILHPTENDKLAVNQWLWTKPTLEPRVARTQPKPPQPPKPVKQQPIHVAPPLRPSFPGPSHSRPPTLPPAAASPAVPQNITQLLPLIQSLNANPAALEKIKNEHPQVYRQLQTQLANIRNNPHAMAQIRTITPGSRPTVPSSRNAAAPIRAPVLQRAAPPRPTLTKLSCEICDTTLDRLQAYLEHMQHNHKKLEGKTLSEMVQGPPLACSRCKDRFWCYDGLERHLVMAHGLVTQEFLRKAQNKQDGGRCQICKKQYAFNMLQHLVQEHNKNLCSAEIRYSCDVCQFSCTVYTELSAHLENSHPKTNGSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXT2</accession>
    <name>A0A914XXT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXT2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11339.t1">
        <property type="protein sequence ID" value="PSU_v2.g11339.t1"/>
        <property type="gene ID" value="PSU_v2.g11339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11339.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46486" checksum="426A30AFA1172557" modified="2023-02-22" version="1">MHFHLDNTQKGTINEYHHVFEQIQRKEKNFKRAKKCQVQQAGRLLINYVSFLINKCYTETLDRPDYCQERLESEVDFLATTLKSVGDAALGDDITETWKNYKNFCELDNAAIIGQDKLLEQALELAHKRATENVYQSAIRQIHERIKELEEVCQKRISEIVSVSKVLKTAVINPGNTLKNLKGFIKDPKGSIKALRKYAKKHPWRFAAICIGSLTIGLVCGGAVAATVAIVDIFVPFSIPVIALAAVAIGTGAVSSTALVNVGVTAEAVVKIENEVNEEIGIEIAKEAEILNQNIEDGKQIASDIKFDQERRKEINKLEKKIFEQKKVEQETREKINKMALVELEGTKEQLDVAVKQLTAELEEFKKDSEKSENMVNEIQEKMSKIDEGKAAASWFVQDAQEKNSSSRMDESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXZ4</accession>
    <name>A0A914XXZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXZ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12816.t1">
        <property type="protein sequence ID" value="PSU_v2.g12816.t1"/>
        <property type="gene ID" value="PSU_v2.g12816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12816.t1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50486" checksum="47967968F55B7393" modified="2023-02-22" version="1">MFPLLSKSDEEKQLFIELVDDCSKTSNQNYTLNSFTAITTETIINSTIVHTLQNSYLKLFKDTELIFCKQILPANYLSANGMNALSIDGECGILLPKFGFPILTTSLFHPVIGKIHLIKTSKEYFVVSDFQSIFDVNETLATLHFSTTPTLSSSCFNFSSSYTVKDSIPIRGFSTKNSKNNIQSFSRFIEFDNIKSVQVDLGWIKACANLTLLPLGVIKGNAILRTHNIAASRHLADIEIFEYPLFNETEIIGFRSGGEPKNNVKNLYFYKRPIDMTISTAPPCSESTFGAKTKLGWENELIEKLGSNKSERLFLKNKALTGNRSIIGLTIMADFDENVVGCGTIELKGQKKIAMAIFNDTNITGFIKLSPTKLFWEIVAMNGGICQTARPFDPFKVQDHNKCHEDIDFCPVGQIVNRSELLTQNSKKHFILHGFSIVDGAAAVLYTLDLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYF1</accession>
    <name>A0A914XYF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYF1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12235.t1">
        <property type="protein sequence ID" value="PSU_v2.g12235.t1"/>
        <property type="gene ID" value="PSU_v2.g12235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036964217" evidence="1">
        <location>
            <begin position="31"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12235.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24814" checksum="D5DF6C202B3E9BD0" modified="2023-02-22" version="1">MDRRRGRLQPFWMFTAALFLISENIQYLKAVRLESDRWIDFDVSKALPSELRDYKKHLSSMLEKVDTAIADYERLKSKRFIPISSTIPDDKSAFILDRVESLTEKNEKQKNISLPLPEALAATDTATQFSPLPSSHYKTILYYFFLQQNRSVEECRRLSQAELVTELKQKGTYNPDLMAWDATGIFRFLDRSIVDQYEVRKDKSVIHFHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYF8</accession>
    <name>A0A914XYF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12989.t1">
        <property type="protein sequence ID" value="PSU_v2.g12989.t1"/>
        <property type="gene ID" value="PSU_v2.g12989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037850982" evidence="4">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12989.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10836" checksum="D7669E4752160C52" modified="2023-02-22" version="1">MTKLLFVCFTVICLTLFIIQNSDAFPAKNINADGLQPEDCRKDEDFLECGTCPKTCTDPNPKCDSKCKPPMCQCKEGTVRATDGQCIKPEECPPNTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYI2</accession>
    <name>A0A914XYI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12266.t1">
        <property type="protein sequence ID" value="PSU_v2.g12266.t1"/>
        <property type="gene ID" value="PSU_v2.g12266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12266.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22312" checksum="3B2628C0755041FB" modified="2023-02-22" version="1">MISKSNKAALQLCAGNKSTSIEPSVPRNYLMMPKIEFDKFFGDDKKWLLWLKRYSTIHNNPTIPDEDKLNMLLSLRDGEPKELLSNLNITAENYALAMSMLTAKYGESKQTVKKLLAEFNELRCFGVTVAETRQCFSSDELILNQLEIMGENVNDQKSIQVHWENNVIPDWLYESCLMRISKDSIYKILSFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYP3</accession>
    <name>A0A914XYP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10809.t1">
        <property type="protein sequence ID" value="PSU_v2.g10809.t1"/>
        <property type="gene ID" value="PSU_v2.g10809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10809.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11714" checksum="B3C5EC744887C0AF" modified="2023-02-22" version="1">MDPTHIPFEPKQISKDLSQTLYNVTLNIAKVNITLNFIESILCNVVIICALLILLLIYWNIKMWLTHKNKEDDFIQRKIDERMFDVQQRQKPSSQNGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYT8</accession>
    <name>A0A914XYT8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XYT8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13107.t1">
        <property type="protein sequence ID" value="PSU_v2.g13107.t1"/>
        <property type="gene ID" value="PSU_v2.g13107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13107.t1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26970" checksum="533889A6A33B5119" modified="2023-02-22" version="1">MDKAYFRSYIRRYACSPQEIRTALKFSLKSSSTDYDEFEEILSQEAIEEEIQNATDSNYGDVGDPVFIAKSCPPESANNYCRNGGTCYAEYHTEEHFTLFCKCAPGFDGRHCQYTYNPKIYESAQVAPDVENASVGSLITVILVGLIIFSGLVYLSKTFCKAHDLRDYMYSESSIDPATMTPVQMYPFSQRSSPSSSLTPISTYTVSHQQQQRQQQQQEQQQNSQITLNSYNHFPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYV0</accession>
    <name>A0A914XYV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYV0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12393.t1">
        <property type="protein sequence ID" value="PSU_v2.g12393.t1"/>
        <property type="gene ID" value="PSU_v2.g12393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12393.t1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20539" checksum="C4810AD821E60217" modified="2023-02-22" version="1">MLFTSNLRKAVDHYQGSPSKTLEQKRAQLIRRHTCSIIVAPSEGSNPVILSQTSIIHKHGLTSSGRQVSFREPFIEEENEEVPSAPPPSNPPPPLPPTYAQPPASNILPPLPAQFGAPPPSAHDEWADPRISTTPTYPILPPEASFPNPASAPPLPHQALAPTQSAAQLHDDDFDDDWSDEDEEVACKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYV5</accession>
    <name>A0A914XYV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYV5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10864.t1">
        <property type="protein sequence ID" value="PSU_v2.g10864.t1"/>
        <property type="gene ID" value="PSU_v2.g10864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="127"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10864.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33180" checksum="D62290DAA6860D05" modified="2023-02-22" version="1">MELLKAKWNATIKVGDLWNTGDEDFTIVVDKKEIEAHKCVLKFHSPVFRAMLSDEFENKIEISDFSFEIVEKIVKILYDRNLVPDFTINEAILILKFAERYSIAMLKPNQKWNITKNFKDFWNIGDENITIIVDEKEIKVYKCVLVCYSSVFSAMFKDNSLNKVEISDFSYEIVEKAVKLLYHRDLVSDISVEEAILLLKFAEKYSIEMLKDNIEEFLGDEITVSNVSEIANCAFGVNAFKLRKKCYGFFINCLSMKYSVPKMELLEKDFLISAISNFSCIKCQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ75</accession>
    <name>A0A914XZ75_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914XZ75"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13246.t1">
        <property type="protein sequence ID" value="PSU_v2.g13246.t1"/>
        <property type="gene ID" value="PSU_v2.g13246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F59C6.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13246.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10684" checksum="197F0450873CB4F4" modified="2023-02-22" version="1">MLEVHSRNQHVAYNDCLMKYRESSDFVIIADIDDILFPKSGSYFKDFSVLNKLHPNAAAFMYDRRFAQINVGMIYFKGEESPLTNFLLDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZM5</accession>
    <name>A0A914XZM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12661.t1">
        <property type="protein sequence ID" value="PSU_v2.g12661.t1"/>
        <property type="gene ID" value="PSU_v2.g12661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12661.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16373" checksum="E4CD0B2E69F8671B" modified="2023-02-22" version="1">MAKYEIFKAQNPENGDFDVVFEIEGKKLYAHKSKLCEVSSTFNEMLSERWTTPNEPINIQKNTFDDFKTFVTFIYSGEFEFDSNNIFTMVDIAECYDVKIFKKACEDYLLKTEWDLINVFPMLDLAFKYSLEDLKKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZU0</accession>
    <name>A0A914XZU0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 22</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12721.t1">
        <property type="protein sequence ID" value="PSU_v2.g12721.t1"/>
        <property type="gene ID" value="PSU_v2.g12721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12721.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17824" checksum="EFDDBFC831E0F35A" modified="2023-02-22" version="1">MNRPGPSGGGGKSAPSGGNSKIMMSKTQLLSDYRSRLRGALRSAAENIQGLALAAKVPSDDSHKHLSQTARTAHYNTVRNELVNRATLIVKAAEELLTLNNDVKSFTILRDFKSVNEAIIQSESAFKQEINRGASSYDGMRLVNAGMSTDLDKELNDHFQRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y037</accession>
    <name>A0A914Y037_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y037"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12821.t1">
        <property type="protein sequence ID" value="PSU_v2.g12821.t1"/>
        <property type="gene ID" value="PSU_v2.g12821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12821.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="11904" checksum="5A56E5632ACFF383" modified="2023-02-22" version="1">MASQSGGPASGEINLSTTRVPSLQLLIDPANMSATNSTNPTSDGGGGGLSGGAIAGIVIGVIVGVIIIAIVTFLIIRKVRDQRKNHGEYRPQLEENLHAKDLPYLPPPNIEGHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1A5</accession>
    <name>A0A914Y1A5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1A5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11615.t1">
        <property type="protein sequence ID" value="PSU_v2.g11615.t1"/>
        <property type="gene ID" value="PSU_v2.g11615"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8206" evidence="2">
        <location>
            <begin position="324"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11615.t1"/>
        </source>
    </evidence>
    <sequence length="577" mass="65862" checksum="FB7A018154C61C06" modified="2023-02-22" version="1">MMLKTYNILVMGQTGTGKSTWINSFANYFEYESLEDALSDDLIWLIPSTFQLSTTDEDGNFKMHTVTIGDHLCESIAESDTQVPQVYSFRHQSFILNFIDVPGIGDTRGIETDNINMKAILNTVGIFEELHGICILLKSSDTKLTTEYKFCLNEVLMHLHRKALDNVFFIITHSQGSNYLPGNSFTTLQAYLKELKSKKGIEITLTPKKLFCIDNEAFRFQCAYKQLPEFQSYDYSTYKKSWKQSRMATMKLLKEMKELKPHEVLQTLSINQARAIILSLIPSLATITAIIQTNATNFEQNFDEIISKLQHSLIITEYTIELEELSKPRTVCTATKCIGVEKDENGKFTTFYKQICHSSCHLTGVPIKSFPEPQLLNCAAMCGQGNCEKCGCHYTLHMHIDFNQKKVAKKSRLGSSCNSSSSGKIITKEDAKELVQKELKNLEHEQEVISDAMIQFSGYLKQNAIFEYNSAFEERMKMEIRNEEAAVKSGGDRVILEKLQNMLDEYIDRKEKLEVALAHATDEIIDPTQISELKNQLFELPIYGGKIKELYEKSTSANYKRNESHNFIERDINLSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y259</accession>
    <name>A0A914Y259_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y259"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12870.t1">
        <property type="protein sequence ID" value="PSU_v2.g12870.t1"/>
        <property type="gene ID" value="PSU_v2.g12870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF256">
        <property type="entry name" value="GST C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="81"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12870.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23701" checksum="3974348C5FA9706A" modified="2023-02-22" version="1">MVHYKLTFFDQRGLAECIRLMFHYGGIEFEDNRISHTQWLKIKPTTKFGKMPILEVDGHPLCESLAICRYLAPKLRLMPNDSWENAQMESIVETYIDFHRDIKPYWIAAFGGPKVNDTLYKDLYIPLSDTYFNRISSILNSTKAGFLCNSGISWGDFYLAEACATLKGIDPDFGKRFPNIIEYQRKVHGLPQLQSYIVKRKSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y419</accession>
    <name>A0A914Y419_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y419"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13978.t1">
        <property type="protein sequence ID" value="PSU_v2.g13978.t1"/>
        <property type="gene ID" value="PSU_v2.g13978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13978.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="10484" checksum="BD242DA360744D99" modified="2023-02-22" version="1">MFAKDAVVDTAVNIKNKTVEKAEDVKDAIVDAGEKVKEGAEVAKDVAVGGAAYVANKTAHGVEKAIDKAEDVKEGIAEAASLAKNATIEKVAEGMVAVEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y420</accession>
    <name>A0A914Y420_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 11 RING-H2 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y420"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14185.t1">
        <property type="protein sequence ID" value="PSU_v2.g14185.t1"/>
        <property type="gene ID" value="PSU_v2.g14185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14185.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8351" checksum="AC26D579EA7CCEFA" modified="2023-02-22" version="1">MAEEGKMDVDETNQDKTQASTGGNLVATNKKRFEVKKWNAVALWAWDIVVDTCAICRNHIMDLCIECQANQVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y437</accession>
    <name>A0A914Y437_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y437"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13996.t1">
        <property type="protein sequence ID" value="PSU_v2.g13996.t1"/>
        <property type="gene ID" value="PSU_v2.g13996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF30">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13996.t1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29522" checksum="04AB64A129611E95" modified="2023-02-22" version="1">MGGTESKPSKEDENNIGVGGGRFTEDKEYRLYRLVDTNSNGGELLPWMRYALNTGDYSLIDGYLDSKLKDFMHNGGKGKLESVAELVKLRNKERNAMLGTFSRKKGKGKSGPNILDDFNQEGNQGDLKKALKLLDGGKSGKGDAKYREIVWKLDDRGRMGENIVGACLMQGSALHNKLAIKILSAYPKLINDIFISEEYYGLSHLHQAIVNEDPYMTNYLLQHGADVNQRCYGAFFCANDQKSGRTDSLEHEYVDLPEKTNYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4A1</accession>
    <name>A0A914Y4A1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4A1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14059.t1">
        <property type="protein sequence ID" value="PSU_v2.g14059.t1"/>
        <property type="gene ID" value="PSU_v2.g14059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14059.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10455" checksum="246CDDCA28B4D98D" modified="2023-02-22" version="1">MQIRDDDKVAGAVFSNPSRSRTSVTKTPITKTNTEVSKDNAANLNRSRTAPNRSRTRTTKSTIEYDCKIIGGEKVFNVNRKLLSEKSIGIQNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4I0</accession>
    <name>A0A914Y4I0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit dss-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4I0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1511.t1">
        <property type="protein sequence ID" value="PSU_v2.g1511.t1"/>
        <property type="gene ID" value="PSU_v2.g1511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1511.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11666" checksum="571BAB48E5691244" modified="2023-02-22" version="1">MSSNQDKSEKSDKSDKTTPKKMSFSLNNPNDPKPSAAANKNIVALDDDDEFEEFPLHAGHIEPVEEDEKDTIWEDNWEDETVGEDFSTELRAELEKMGHKAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4K0</accession>
    <name>A0A914Y4K0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4K0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14158.t1">
        <property type="protein sequence ID" value="PSU_v2.g14158.t1"/>
        <property type="gene ID" value="PSU_v2.g14158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14158.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36197" checksum="406716C74CDE8217" modified="2023-02-22" version="1">MENSVFNNAYLPEKVLHLEIIKNVDDYWPEGLTFRDVFILQMPVTQKLLNHLEEFNTRPVPAWMYLAYPEAKKLLKNRDPLMVIHMDLSKIMKLENQLNPNTVPYPFNMWLKQIADAKSEFENIKILKKDKIAYTVSGDYCNATLTYTMSANFPFEQPIIDGHFLIGWLLDGILIIRQTLKIYCERYAGHIKTFEPLFEYISSLCLPGARVILIGDNGDPIEMNEMQQLKIIQVKYLEIFCKTLPSSFEMDALYVEVLIDIDKFDLYPHKIDILPRDLGLIANEEFWKQENTLEQNLYDCIIGHEPMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5M0</accession>
    <name>A0A914Y5M0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5M0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14538.t1">
        <property type="protein sequence ID" value="PSU_v2.g14538.t1"/>
        <property type="gene ID" value="PSU_v2.g14538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14538.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12272" checksum="E3F6ADE7D9073984" modified="2023-02-22" version="1">MKISSNIIDMRWKEIHFIQEAIEMMKEQGIEESLVKDFELVVGVLEWEMDEKNVLESDLPPLGPESTKFADISTWSILFFDLLHDNMHRIVDLNYSLKMLTKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y762</accession>
    <name>A0A914Y762_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sulfatase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y762"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14583.t1">
        <property type="protein sequence ID" value="PSU_v2.g14583.t1"/>
        <property type="gene ID" value="PSU_v2.g14583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF53">
        <property type="entry name" value="ENDO-4-O-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Ser)" evidence="6">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14583.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13002" checksum="3589A9D7CA0E95D8" modified="2023-02-22" version="1">MDDLGYGQLPFDKGSFDPKTMKNREVVDTYKIGIDKAIEAAQKSTPTLLSLMDEGVRFTNGYVAHGVSGPSRAAIMTGRAPARFGVYSNTDAQDGIPLTETFLALKFIPESWLLHCSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y765</accession>
    <name>A0A914Y765_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y765"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14588.t1">
        <property type="protein sequence ID" value="PSU_v2.g14588.t1"/>
        <property type="gene ID" value="PSU_v2.g14588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF49">
        <property type="entry name" value="NIM1 SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="157"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14588.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="29503" checksum="D8253C66FDA65188" modified="2023-02-22" version="1">MTMIVEKSSCQLPPASPLYEQSLSSSMESLEIRTNPKLSNESDESEGTAATTATTTTSPSFSSASSGSGSGIIPNKPMPKSVAAIAARHKFEKAPTLTCSSSEDHPSDDIPRHASTSSLPAFPVIPSQSLYEKTKLQLEEDEGVQREISLGKRIGFYRLGKELGAGNFSKVKLGVHCLTKEKVAVKIMDKSKMDQKAQRLLSREIASMELLHHPNVIRLFEVIETLSKVYLMMEYAAGGELYTYVHENGKLTEETAKPIFAQLVSAVAHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7R4</accession>
    <name>A0A914Y7R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7R4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15315.t1">
        <property type="protein sequence ID" value="PSU_v2.g15315.t1"/>
        <property type="gene ID" value="PSU_v2.g15315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15315.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8754" checksum="F4116DE17902BF6F" modified="2023-02-22" version="1">MRFGNVRGLYDHDIVFWLGDLNYRLDSPYGYEHVVNVIESGNTNTLLEYDQLRKQQQLRHAFLGFKELLGMGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8A3</accession>
    <name>A0A914Y8A3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8A3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15676.t1">
        <property type="protein sequence ID" value="PSU_v2.g15676.t1"/>
        <property type="gene ID" value="PSU_v2.g15676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15676.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13795" checksum="1CC9EF99C563E734" modified="2023-02-22" version="1">MQAGLDGAQVAVVPESDEFWDYVLNGTYEPAGSDSELSRDETPVVHSLRVSEQQTVQGNTRFTQLTITFDVHGELASAEIWAGPEGHELVHVADTYTRQATFRIDVAGNWMVQVRPMGHNRAGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y967</accession>
    <name>A0A914Y967_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y967"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16739.t1">
        <property type="protein sequence ID" value="PSU_v2.g16739.t1"/>
        <property type="gene ID" value="PSU_v2.g16739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037540661" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16739.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17608" checksum="83686668E3D12FC7" modified="2023-02-22" version="1">MKLLLLFGICLILCFQISHQFPSGTKEVKAPFRKDDEISVNTFSELQNKRLGKYWKTHGIRSVGESEDGIGNGVKIDSNTNADAKETELSKRGLIKKVYKKMDEKVKDPRNYVPILLKRNVKDELTDNNETPLVGVPSDFDLGSGVITDKDNIKPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9Y7</accession>
    <name>A0A914Y9Y7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOB-like protein phocein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9Y7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1434.t1">
        <property type="protein sequence ID" value="PSU_v2.g1434.t1"/>
        <property type="gene ID" value="PSU_v2.g1434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1434.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="26594" checksum="E891AB257CDFF53B" modified="2023-02-22" version="1">MEQRILRRNDPGCKKADWYNWETQKIDDLKSLLFIQEWIQQTIRENYKDVDGILKCPQGVEEGVWKYEHLRIFCMELNRLTVGLQEECNPACCPQMTATEQWIFLCAAHKNPKECPAIDYTRHTLDSAATLLNSYRYFPSRVRIKESSIAKIGSICRRVYRIFSHAYFHHRKLFDTFEENTYLCRRFTMFVIKYSLMAPEHLIVPILNEPSTVSSPENVVDKDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB86</accession>
    <name>A0A914YB86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saposin B-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16680.t1">
        <property type="protein sequence ID" value="PSU_v2.g16680.t1"/>
        <property type="gene ID" value="PSU_v2.g16680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044194">
        <property type="term" value="C:cytolytic granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038847">
        <property type="entry name" value="Granulysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15541:SF2">
        <property type="entry name" value="GRANULYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15541">
        <property type="entry name" value="GRANULYSIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038126154" evidence="2">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16680.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10860" checksum="06FAB5F22B8BFDB7" modified="2023-02-22" version="1">MIFAFLALIVVDAVVLQTKGVGCTLCKDFVKDLETELQNDEGTIEEKANKICDKLTHNNSFLDPLCKSLVDNELETIVDGIEKKDPPEKICKKIKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBC4</accession>
    <name>A0A914YBC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBC4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14785.t1">
        <property type="protein sequence ID" value="PSU_v2.g14785.t1"/>
        <property type="gene ID" value="PSU_v2.g14785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14785.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21786" checksum="659B8A79CD1AD74B" modified="2023-02-22" version="1">MITNIAMDYAATEDGSQEHIVRSAERMFFARGRLSDSFDTALLRFNECLQTMNSLNTDPVPQIFPAYGGIDEFVPVIDDDINDPFGIESVSFRAFIFTDANENQDFVNAFEEHDSTQNYPVSDSSDYADDQHYNNNPANDNDQHDYHFNNSDNVDYHNVPTYDEEYDDFRPGVWAPLSQLFSLSRVNHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCD2</accession>
    <name>A0A914YCD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCD2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16957.t1">
        <property type="protein sequence ID" value="PSU_v2.g16957.t1"/>
        <property type="gene ID" value="PSU_v2.g16957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581:SF3">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45581">
        <property type="entry name" value="PROTEIN CBG10435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037204329" evidence="2">
        <location>
            <begin position="27"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="162"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16957.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28723" checksum="C6CC92A46C6746D0" modified="2023-02-22" version="1">MITKIFMYLFYLFRFATVWLNGMVNGKIIEMNESGNKFWIANENLAALTGDVPAAGLVYTRLVSMVSSRYNEAIKSAKEKPDEIKPKENDQEVHPHGHGKTHEEHGSNHGHQHGHNHSGGHGHDNHAEQFPLMELLSKTMYKKHLIPDFMPLFGVREKLQNGGIEILDVGCGSGFHICEFAREFPNCNFTGIDISQSAIKRAQEVAKEQSLSNVKFEVISGEEMPAEWDNKYDWVFSWNSIHDHKHPKTVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCV6</accession>
    <name>A0A914YCV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCV6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17265.t1">
        <property type="protein sequence ID" value="PSU_v2.g17265.t1"/>
        <property type="gene ID" value="PSU_v2.g17265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17265.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25307" checksum="D2D64D1CED3469BE" modified="2023-02-22" version="1">MFLYQKQKKPATIFDEKPKEILAENKTILESQKIEENVGNGKSEKPKEAGKANKETTEEKQETVEEKLVKKDVPKKQKKVEKPKQKTIKIKIENVPAKKKAASVEPNLDDPTTEASIVQKPKVKEHSRVSKELILTVPKSHVKRIKPKNGASTKTDSLSRRHEVGMIGLVESPSQTDSQSLKLHGKGLCRYHVIEKLAFFTLPTHLVMNIKDCCRQLQSGVIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCZ4</accession>
    <name>A0A914YCZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCZ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17301.t1">
        <property type="protein sequence ID" value="PSU_v2.g17301.t1"/>
        <property type="gene ID" value="PSU_v2.g17301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17301.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13589" checksum="146CD11035EF665D" modified="2023-02-22" version="1">MKKTIVADIIAKKLNIFGFPAVSVHGKQLFRVRQKLLQKFIDGEVQILFATNLLTRGTDIDVQYVINYDLPEDYANWVHRCGRTGRNGKIGVAITFIDKENTNDYPILTLQQIALVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD77</accession>
    <name>A0A914YD77_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OBG-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD77"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1541.t1">
        <property type="protein sequence ID" value="PSU_v2.g1541.t1"/>
        <property type="gene ID" value="PSU_v2.g1541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1541.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23605" checksum="E60DB46EFCD88530" modified="2023-02-22" version="1">MKAEVGGQGECVNYDLEMRVMATAGFVGFPNAGKSTLLRAISRAKPKVASYPFTTLQPHVGIIHYDDFEQVAVADIPGLIEDAHLNHGLGFSFLKHIQRCQCIFYVLDFSLSSLTEQYESLKRELRLYNEEMIEKPSAIVINKMDLSKDSTENVQSYFPNMKVFPISAKNKENLEPMLIYLRQEYDAYVAEQQTKINAEEDDYVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDY2</accession>
    <name>A0A914YDY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AAA+ ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDY2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17509.t1">
        <property type="protein sequence ID" value="PSU_v2.g17509.t1"/>
        <property type="gene ID" value="PSU_v2.g17509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="174"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17509.t1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44768" checksum="5656502858CAF3C8" modified="2023-02-22" version="1">MVDTSMPSVGDEKEKALSHYRRKLNEHRDIDARLKELRKKESQMQKEHDKSENDIKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRSINKEALKQGTRVALDMTTLTIMRQLPREVDPLVYKMSHEDPGNISYAEVGGLSEQIRELREVVELPLINPDLFKRVGITPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDSLGKVKIIMATNRPDTLDPALLRPGRLDRKIEIGLPNEQSRLEVLKIHATNIAKHGEIDYEAVVKLSDGFSGADLRNVCTEAGLFAIRAEREYVIDEDFMKAVRKVSDAKKLETKLDYKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE14</accession>
    <name>A0A914YE14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1754.t1">
        <property type="protein sequence ID" value="PSU_v2.g1754.t1"/>
        <property type="gene ID" value="PSU_v2.g1754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1754.t1"/>
        </source>
    </evidence>
    <sequence length="376" mass="41775" checksum="84F8A282F6E8C1C6" modified="2023-02-22" version="1">MALKDTTPNAAKLERVLGCTACPSSFAIDQTTGMIAYAAGSTVVLITKNNGQFHFVNNSKNNITCITFSSNGKYLATGEFGNCPMVRVWEICKDGTFQGQQIAELKYHTLGVLCVKFTHDSTQLISVGIQHDKSVAVWDWRGQKKIAENRLTSQVNAMDISEDGNCFVTVGVRHVKFWMLNGKEKALSGRSAILAEQRNNTFLDICCASGNRAFALTDTRLLVEFFDKKIVNTFELTGEIPYSITLGPLNHLLIGFSNGHVRAINTETIEVQQLPGIPHFLHHDISTASEHETFYQEGINAVKANERFPDVKALLFHQKSKTLTALYSDRSIYQYLLTDTFGQSLLIGYRNHVGAILDLEMVPKNLPWLPAGTFMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE40</accession>
    <name>A0A914YE40_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE40"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15682.t1">
        <property type="protein sequence ID" value="PSU_v2.g15682.t1"/>
        <property type="gene ID" value="PSU_v2.g15682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15682.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38323" checksum="F0AF384FC484E42E" modified="2023-02-22" version="1">MKFLRDATAALEEVPHEIQAPHYEDHFAASDDSYEVYEEVLPETVVVEPSTSEYYESSNGQQKVIAKADPATEYILDPTLHVIDVEDINELHDNKELITVVDVPVEMAPEASAVNKTFYSPTRRKHRKPKNLEWIINAVAAGKRLDDATPHRRKKPTIKDCEICGLTLKYPSKIAAHMRTHTGEKPYLCDICGRGFAMSTTLRMHVRRHLNAKMFPCTYPNCTKSFVNGALLNYHVQNRHFTRRKFACLRGCGSTFYSNKERERHEKDCIPSMVQEDDDNLDYEEFVNPHTGETEKWVFNGYSGESWEDSLMDNGMVDESDHIQILDDDEDGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEN3</accession>
    <name>A0A914YEN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEN3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18727.t1">
        <property type="protein sequence ID" value="PSU_v2.g18727.t1"/>
        <property type="gene ID" value="PSU_v2.g18727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037985108" evidence="1">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18727.t1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7732" checksum="3FD2918DC4D14982" modified="2023-02-22" version="1">MAENVLLLTWLDFLLADSTDAALAFVKPEHEKLFEPLKTHRDCIFALPLLEKRLQERKELQKNQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFL1</accession>
    <name>A0A914YFL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17547.t1">
        <property type="protein sequence ID" value="PSU_v2.g17547.t1"/>
        <property type="gene ID" value="PSU_v2.g17547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000358">
        <property type="entry name" value="Tau tubulin kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17547.t1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42586" checksum="34F5801FF904154E" modified="2023-02-22" version="1">MAAAAAAAVGTDEPGPVELPIGKTVAKKWKVIEKLGEGGCGAVYLVEDTKSRARAALKAESNFVAGGSVLKLEVQVLKRLAGRKYVAQLVTAGKKERYCYMVMTLFGHSLGRLFKFCKREFTPSTQVRLGLQMLYGLKQLHEVGYIHRDLKPANLAIGKKGKATRVVHLLDFGLSREYIIKIDGKTEIRKPRENTLFRGTTKYCSAHANCRGEQGRVDDLWSMVYVLAEMRGPLPWDQLRDKHEIGKMKKATSDEKLLSKCAPPMLEIAKHLRELDYYKRPDYAKIYHILDGIMVDLGVNYADSFDWEVLPNYNQLTTEKKPSKGTRKTKIITVSEDVSIAKTTESSGKHRKDPTLQSEECDDKPPFNPAEFEKNELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGY4</accession>
    <name>A0A914YGY4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGY4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18719.t1">
        <property type="protein sequence ID" value="PSU_v2.g18719.t1"/>
        <property type="gene ID" value="PSU_v2.g18719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18719.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31428" checksum="A3899F6FE0A200CF" modified="2023-02-22" version="1">MDTENQQKSASIPSTNAASINNGPNAHFDYLKGWYNYVNEFNVVKTAKAGYDIAKHSTALTENAFNKVENGIQTGLTNVAAPVYANYCYPATDRILQYYNKSVDTTKCAADKAFDATSYAAALSIGLAVVATQMGVLVTTSAVNAFLTSLLYTKQAGTTALESAAHARSNVENIIHSALEQSQKIAKVPAEKANEHANTFLDVANTVFDRLLGLPEASEPADSQISDRIIFLSNRVTKFCHSEIWRGSNIVVENIFDSDDNEDFFERLHYNIPNPHRQRVIALHNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHA4</accession>
    <name>A0A914YHA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18846.t1">
        <property type="protein sequence ID" value="PSU_v2.g18846.t1"/>
        <property type="gene ID" value="PSU_v2.g18846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF7">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18846.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29428" checksum="2A856D93EBF0AEC2" modified="2023-02-22" version="1">MNDMPMPICTYTIRKDEIDGPILKYAKVGDQVVHRWECDSDIYGILVHSCYVEDGQGVKSMVVDDKGCHKDRTILGDPTYAEALNLAYRESYVFKFADKIGVRFQCEIRLCVKESGGCNGITPPTCDDHPSREWMNNNNTSTKNTRKLSKRSNPSTTISPKMTIDTDLISQFVYVIDDDGEVSPLINGNEQLSSAASVIPLFSSQRICLSNVFFIFFACLFLALFSVTVALGIFFVRKQNRAKLATVVDSTPRIRPFTMVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHE6</accession>
    <name>A0A914YHE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19748.t1">
        <property type="protein sequence ID" value="PSU_v2.g19748.t1"/>
        <property type="gene ID" value="PSU_v2.g19748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19748.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="16696" checksum="A35F5281CFAF038E" modified="2023-02-22" version="1">MYGGGGGYSGGYGGMGGMGGMNSMNSMNQMSSMGSMNSMNSGYNNMLLNPYMDSMSGMGGMNGYGAMSPLAANPLNAMGGMGGGIGGLAMSPYSAYGGYGMGNSSPQYYNNGLSFSNYGNTGTPSNNNLNGLQTQATGSGGSYRSQPSTGNCGGRRCAWETTATKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHS1</accession>
    <name>A0A914YHS1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YHS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19876.t1">
        <property type="protein sequence ID" value="PSU_v2.g19876.t1"/>
        <property type="gene ID" value="PSU_v2.g19876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="246"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19876.t1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45071" checksum="BB6D6F87E42F5514" modified="2023-02-22" version="1">MAWSGIAASLYPKGRTCHNVFRLEFPFKSDSNSLLNEEIKEAQKIRDAKVIFWDEAPMAPKQALKVIDLKLRDLMGIDSPFGGKIMILSGDFRQIPAIVENGGPMDVVNASICNSPLWPLFKKFELTENMRANKNEKQFTEALLKIGNGETIDEDGCVDIPDHCVVQGNLAEEIFGDLIAEKKFEQLTSRAILAARHDDVRGYNDEVMQMLPSEGEMTFNAQDAVKHGDGELHWHGVPQYFKDNHINGFPSHILTLRINSVIMLLRNLSIEEGLCNGTRLLVTDLRPNVIAARKLLHDGTLSAEKIMLPRITLKHDAGPFELYRHQFPVIPAHAITVNKSQGQSFDMVGVYLEKEVWSHGMLYVALSRTKSWDCLKIQLKKDRVNKTKNVVYPELIAQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIC9</accession>
    <name>A0A914YIC9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Receptor ligand binding region domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIC9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19251.t1">
        <property type="protein sequence ID" value="PSU_v2.g19251.t1"/>
        <property type="gene ID" value="PSU_v2.g19251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038010067" evidence="12">
        <location>
            <begin position="25"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="13">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19251.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25021" checksum="B313BC2DF5EF528B" modified="2023-02-22" version="1">MNNFISAFYDAVLLYAIALNETLAEGLDPRNGRNITSKMWNRTFVGITGNVSIDQNGDRYSDYSLLDLDDNQDKFMEVAYYSGAQNALRQVSDFHWVKGSPPKDSPICGWDHSKCPEGYPFYYYALFAALVVILLLLAGVLLFYRRYKLETELAAMSWKIRWEELEGDDVARKEKKKKRARKTDFYNHPDQSVPFLRSNSRTSNNSDKVGHFFIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ74</accession>
    <name>A0A914YJ74_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJ74"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19357.t1">
        <property type="protein sequence ID" value="PSU_v2.g19357.t1"/>
        <property type="gene ID" value="PSU_v2.g19357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053295">
        <property type="entry name" value="Innate_immunity_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324">
        <property type="entry name" value="PROTEIN IRG-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036903265" evidence="2">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19357.t1"/>
        </source>
    </evidence>
    <sequence length="311" mass="33948" checksum="FD0EED6C112CDA15" modified="2023-02-22" version="1">MTASFLLCVALATSYVVTGNGFHMFETKSAHSCLNDGYSNGTDACECKDPNYISGVNCEIWKCINFGKSIARPDSGNQFLKGCDCPPGFRGLHCEPTACIPNSDGFIRAFNPVENIFSIIITYNQRFIDVINRGDTIIDSITEMLQGAPFNTSAIDSLHVHLIGGSVYPLDCPSSTSDPLAISKCFKQEMSDYVNYFGPFNDTTLTTSILLSQVQAASTYSSVLLVTNIGISDNDNSQQINLIAQSAVARQIELNVIIVEPIDTQGRNIFFSPRYIPLIDLVHKTLGTFIVPYQINGGPNGLPIKDVIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ99</accession>
    <name>A0A914YJ99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJ99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2041.t1">
        <property type="protein sequence ID" value="PSU_v2.g2041.t1"/>
        <property type="gene ID" value="PSU_v2.g2041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2041.t1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45741" checksum="9B11BCE290A6048C" modified="2023-02-22" version="1">MEFFSFGGGGTGPESSPLNTALQIPNDTFVGRIIPDFKYTFPVNFSLIENYPTENYAPNFFCIDALYGTFVSLYWNQQHPKNLPEAHYYIINEKDIKKTELIDRIVLKDFDQDVLKDIFNNVIDSYYFPTFSSYGRQIFIWFKRPSENRIFNGIWKNETAYNTHFQDVVVHWNYQNISLRKLFYAKKDWIQYDRPVGRHDAVSLPPPVTVPPSNYKPPTTPIPTTSTSVTTSTPVTTSTPVTTSTPVTTSTPVTLKPTSELSSSAPSTTKNSYSTSSQDPTMDNDLYSTATIATSNFSTVTASDDLAETSTTSNLTATNNQPSATNNETNSSNHQSAKLSSQKLPIPNCSDIIYNNLWFLILLICIIIIEVIILVMLIIFKYRGAKKMKKAMVKKSMHSNKTEAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK50</accession>
    <name>A0A914YK50_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YK50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17687.t1">
        <property type="protein sequence ID" value="PSU_v2.g17687.t1"/>
        <property type="gene ID" value="PSU_v2.g17687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17687.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15516" checksum="5F5BB1389681C73E" modified="2023-02-22" version="1">MILSIAILASDQPPLYFRCSSNESSREDDLRLFVYSSLDVFDEKVSSTVSKPHQELFLGSLFLNNKYRSYGYLTNTQVKILVVVDATNPNLKEQDIRALFKKIHNYFCAAICNPFYELGSPINSRPLNALVDNKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKU0</accession>
    <name>A0A914YKU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20965.t1">
        <property type="protein sequence ID" value="PSU_v2.g20965.t1"/>
        <property type="gene ID" value="PSU_v2.g20965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20965.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17098" checksum="D64A41CD5E657DDE" modified="2023-02-22" version="1">MDIYQTENECDFSSEITDNVCNDSSFNNYDDVVGAGEDQQLQVLLNSAGHAYIAMIMSDSQLLLIECPFKVGSDPLKEVFLQGSRRLTILWKNNDERNGVVDVSSLLDGDDIYFFAIYKNAKIRVWSAVQKKALVTTSVSSLTANADPIEVTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMY9</accession>
    <name>A0A914YMY9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YMY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20303.t1">
        <property type="protein sequence ID" value="PSU_v2.g20303.t1"/>
        <property type="gene ID" value="PSU_v2.g20303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20303.t1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16613" checksum="30E9A89D459D4A00" modified="2023-02-22" version="1">MNFDENNVCVSFTEPLIHTFCKNSSVITGERPFFHHVRNRSNVILLGDSLGDIHMDVGMINEGCALKIGYLNWDFDKLYDKYLDSYDIVLLDCQSMEVPLEIFRFCGIAHTPSEVNLTDYCHSAEAGKTSSEDDTIVIASVIASANVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNB4</accession>
    <name>A0A914YNB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18823.t1">
        <property type="protein sequence ID" value="PSU_v2.g18823.t1"/>
        <property type="gene ID" value="PSU_v2.g18823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18823.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11908" checksum="677A396B73E791D7" modified="2023-02-22" version="1">MATPVHELCAGYPEAFAEYLNYCKNLQFEEIPDYNRLRQLFRQLFHVQGYSYDYVFDWNLLITKRHHQIHQTAPPQPSIPILPANHAANHLTQKTSRVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNS0</accession>
    <name>A0A914YNS0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNS0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g190.t1">
        <property type="protein sequence ID" value="PSU_v2.g190.t1"/>
        <property type="gene ID" value="PSU_v2.g190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="73"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="166"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="369"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g190.t1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55369" checksum="26DDB9512F538F27" modified="2023-02-22" version="1">MFCFNVLKLNTSKNAKIGVKEGDLQIPRLPTGISYFVRIKVLGDENQVLVETPEIRARNEIVSIKCEADEITSPRDIETKQKGQFSVALSWHPPECGSVGEYQIELRGLAEGKFDVHHQTVAQPSASVTNLLPNTEYEVRVRAVDRSKTVGPWNSDAIIVTTKGDAPESSEAIKLEYTSDTDARIHWTHTDEERLQQYEVVLVEFENNEVQRIERTRVSPDRDSFLFVDLTPNSDYEIGVVAYVDHEPRKVYRLSLTTAAQPALLVDIEPIIVKDGDNHYTVHWKKPDGVAATKFIVEYKPANETRWMRLQEDRNVNEDEENYSVSATELNNAFSVRVVVVDDEQRAVAKTKEALVSGGIGSCEGNAGAPNEIRVQPSGNSITFSWKAPTCDQDLSSILGYEYMIWDQENGVPPETTSFTPKSSVTIDSLNPSIQYSFRARSRLTNGHSSWSETIESVNNQKSGWFLIFFKHCSISVLDLSPLFIFCFDVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP88</accession>
    <name>A0A914YP88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP88"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21237.t1">
        <property type="protein sequence ID" value="PSU_v2.g21237.t1"/>
        <property type="gene ID" value="PSU_v2.g21237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21237.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8469" checksum="3AB0084D578F79A8" modified="2023-02-22" version="1">MEMYEQWPLLEFSNIKDSILSKFSIDAGTSVAHLLVKELADNIDTPTNATISTEQDLEWIMQVRFWITVTMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPE3</accession>
    <name>A0A914YPE3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPE3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2702.t1">
        <property type="protein sequence ID" value="PSU_v2.g2702.t1"/>
        <property type="gene ID" value="PSU_v2.g2702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="175"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2702.t1"/>
        </source>
    </evidence>
    <sequence length="462" mass="53130" checksum="BE6248FD159CBD4C" modified="2023-02-22" version="1">MDEFFVRRLDNNQMKVMAREWRRRFQGNKQRAVIELAKFFVKCCGVEMDLDENDLSDDEAKVALITQIEEEVQGKPEILANGNLSTHDFQINLIRFFMQWTKVVVPEVFVDPFCETFYEFLIDLSECGAQSVRLTATLALTKIGTELLGTCLTLHGSTHLPALRGFSRDIVSRVFALRYLDGNWRVRLVIMKELAVWFSEYSNAISSETLLKYVSCNITDPSSAIRTECASILNEYVSRIHVLPDFLKTMFEEKKNVFIQMTFEPSHSLSCSAIALVTNVFTIYPELFEVEEHKAIMMNIYDPDPLVAKQTAKFFVATFPTALETTVEKIDFLITYFQSLEFYPEILGSVLYGEFEPLSDFDAMCDHIQETEDLNAALNYFKLVTYAVLALNKESSTPTAPKRKKRKMDDAEQDKTNFIHAFQPCINEIIEKYGQLNDDWTKTCGIFLHVFDLLVETELPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPT9</accession>
    <name>A0A914YPT9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPT9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21478.t1">
        <property type="protein sequence ID" value="PSU_v2.g21478.t1"/>
        <property type="gene ID" value="PSU_v2.g21478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21478.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="21865" checksum="B994039C2CFE59C3" modified="2023-02-22" version="1">MRLGFALAGQRQFGVARQWLHQARGDDDHQLLVLALVIEVAEERTDDRQVAQQRNLADVGDDVGADQAADDETLAIAQLDGGVGAAGGDRGDLHVVEHDGIAVVQVARFGRHLQRDAICRQHGRGHGQADAEWLVGDGGGAKPLRFQDRQFAAGQETGALPGQRHQRRLGQHAGHAIALQQFDVGVPQALGRAEHQAECRGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ47</accession>
    <name>A0A914YQ47_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQ47"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21152.t1">
        <property type="protein sequence ID" value="PSU_v2.g21152.t1"/>
        <property type="gene ID" value="PSU_v2.g21152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036767946" evidence="4">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21152.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24314" checksum="7239A133017B88CD" modified="2023-02-22" version="1">MRKFIALLLLFVFVSDEDAGKEKKYGTIIGIDLGTTSSCVGVYKNGRVEILVNEKDNRITPSYVAFSADTGDRLIGDAAKNQLTTNPENTVFDAKRLIGREFTDKTVQADMKLWPFKVTNQNGKPYVNVAVGSERKEFAPEKISALVLTKMKNIAESYLGYEIKHAIVTVPAYFNDAQRQATEDAGTIAGLNIVRIINEPTAAAIAYGLDKHNGTLFSLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS85</accession>
    <name>A0A914YS85_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat EBI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YS85"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3591.t1">
        <property type="protein sequence ID" value="PSU_v2.g3591.t1"/>
        <property type="gene ID" value="PSU_v2.g3591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3591.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12964" checksum="DCCCB22D457F0D0E" modified="2023-02-22" version="1">MDLETTENFSISWNPKAPYLIGIGFSHGNARYWYLPLENPIVKWDAADLKTRWRHLVYPNNTNSQEIDKKASIPSTDWNHDGNLLATASRSGVVKIWTSEGLLPPFFMRDTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSB9</accession>
    <name>A0A914YSB9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YSB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20296.t1">
        <property type="protein sequence ID" value="PSU_v2.g20296.t1"/>
        <property type="gene ID" value="PSU_v2.g20296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="143"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20296.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38262" checksum="9D4BB90BE2C14DD6" modified="2023-02-22" version="1">MSPPATVAEEQVVVMDSQGPEGDSLPPTIIKFRGKEFNVDKWLDQVSLCRYLPEDEMRTLCAILTAKISMYPNIAAVSSPATIVGDIHGQFYDLMVLFEKGGSPTDSTYVFMGDYVDRGYYSLESLTYLFLMMLKFPGKVVLLRGNHETRRVSHQYGFYEDCHKKYCHNAVWKACCEVFDALPIAALIDEKIFCVHGGLSPNLPTLDSVMCLQRNIEVPPNGPLCDLVWSDPEESVSQWCMNPRGAGWVFGRDVAEQFVRKNNLTLICRSHQLVQEGFKYIFGNFLCNVWSAPNYCYRCGNVASILKIAPDGTRDVVIFSAVENDDRRIPERNAAPYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSG9</accession>
    <name>A0A914YSG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSG9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3110.t1">
        <property type="protein sequence ID" value="PSU_v2.g3110.t1"/>
        <property type="gene ID" value="PSU_v2.g3110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3110.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15343" checksum="C74516EFD890CD28" modified="2023-02-22" version="1">MGRSGKPKPPKPQSINQHPKPNETSLRISFLQQAAKLMAEKSHSKNDTPSLLSKLYMEELNEVRNIQQTLLSKDLRRSYCRYCNRIWIPDQSGENGIDVKITKDRIYRKCKDCNSMASFVRNPKYQSRNEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSX7</accession>
    <name>A0A914YSX7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSX7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20534.t1">
        <property type="protein sequence ID" value="PSU_v2.g20534.t1"/>
        <property type="gene ID" value="PSU_v2.g20534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042421">
        <property type="entry name" value="C3orf33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434:SF1">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20534.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35179" checksum="B63BBC5142C0B764" modified="2023-02-22" version="1">MAAPAGDLPNTTQIRVIDPVDRYSALIVRGTIVGTGILGAVLFIRNSRLFAKFEHVSKIPKDFIRKELELKGTVREVTPSGYIRIEHRPIIRLPSIWPSKSKKPIGLLNLRLAGLDISKAGLSYIQKDIRLDNKPVTFTVVKPTEGNSDAYDGVIQMKKSTLNRVNLNVDLVRRGYARVFAPENPIHLKALQHNSAYSRLITKLLTSEKVADRRGIGVWERDTWVESVSSIPSQTGQLLRSNPITKLLILLYHVLRDLSFIAYQLAKQGYHLGVTISQYSAVGYRRFAHGVDKLTGFYASSKNRLAGPKAVAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTB7</accession>
    <name>A0A914YTB7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tartrate-resistant acid phosphatase type 5</fullName>
            <ecNumber evidence="2 6">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2 6"/>
    <dbReference type="AlphaFoldDB" id="A0A914YTB7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2909.t1">
        <property type="protein sequence ID" value="PSU_v2.g2909.t1"/>
        <property type="gene ID" value="PSU_v2.g2909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036719514" description="Tartrate-resistant acid phosphatase type 5" evidence="10">
        <location>
            <begin position="19"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="176"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2909.t1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41361" checksum="036BA47592013AAA" modified="2023-02-22" version="1">MKVLIISVLYLIVKLVSCGEKLTELQNRLACTSVDGCSTTDNLIDFILIGDTGGLPPPFYTSYAQRKVAESVDKLATEAKAKFILGLGDNFYFNGVRDLDDSRFWRSFEDPYKVPLLPWFVLAGNHDHLGNVTAQILHTNRSNLWTFPRLYYSIKYRFGNPSKTLQIVMIDTIELCGNCIDVEGEDIISWIWHKKLVPDHPANQEVADKQWKWLENELSQSKADYLFVAGHYPIYSVCEHGPNTCLISQLDPLLRKYNVTAYFSGHDHNLQLLRHTNDTDQTSLMYIVSGAGSRSDRSKKHLNAIPEGSLLYSYPKGWNPFSQIGFSNGGFVKVSVGAENGSFSFYSGSLDNHYKQTFYPRRINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVZ1</accession>
    <name>A0A914YVZ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVZ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4291.t1">
        <property type="protein sequence ID" value="PSU_v2.g4291.t1"/>
        <property type="gene ID" value="PSU_v2.g4291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4291.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19408" checksum="A646F6195C39FF67" modified="2023-02-22" version="1">MQKNTFSKVVNKSLIIMSIFESSDNSNSSSNCDDGECFSIEELRTKLKLDEESVNWLKNTGLPEEDPLLIVEIHCQRCFTDKMLIFAALVANGAQKIGPNSFQFNTWNDIYRTKNILWGQYRWAFYNSDPLTAQQLHISSEPTITTTAITSYTEGKNKLVVNPYQFFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWI4</accession>
    <name>A0A914YWI4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FLYWCH-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g447.t1">
        <property type="protein sequence ID" value="PSU_v2.g447.t1"/>
        <property type="gene ID" value="PSU_v2.g447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g447.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10778" checksum="ED72155A60435E2D" modified="2023-02-22" version="1">MLKNIVKQWKKMALFTNCLKNGFHFNVICRGSTYNFSHLKNNGLAVFRCVNDDSDGKRCQGLIHVKNYDKDNITEGDTVNVSTFGKKHSCRHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXJ4</accession>
    <name>A0A914YXJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Apple domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4686.t1">
        <property type="protein sequence ID" value="PSU_v2.g4686.t1"/>
        <property type="gene ID" value="PSU_v2.g4686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="919"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="324"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4686.t1"/>
        </source>
    </evidence>
    <sequence length="944" mass="107064" checksum="F97327853587C777" modified="2023-02-22" version="1">MKNATNSRIRIDKPKPKPTNATVEEDITLPPTIVAVSEDVETTKSSSKKDSIKHLLKPKSSKSNKTKKAKKTLTPKTTALPSTTLDTPTFSFNDSSIEEENEFGNFSEKPEIVVRGIEELCVRIHNNTAFAGIEPFETQLLKNAYECQKACVATFPRCVAVMFFYVHNQTNEHICYLFDHNSIDPDVQLIEEKPKHDEDIIRALEIVLDCHQFDPFPPLGEDGIVSSTDKVPRSKRQDSKYIEIETSGPWSPWGQCLPSGVQARSQACEYGRKIQRRGCPARNYYAQQQQQQVDQQYQQQQQQYFSQQQQHQQEAQERQRIIDQQRQQQQYDPRQQQPQQQQQQQQQYDPRQQQPQQQQYDPRQQQQQQQQPQQYDPRQQQPQQQQQQYDPRQQQPPQQYPSQEQLQVQAAPTIRTSEPVSYPPQGYKEDHDRQREDMERKREEHMKEYERRQQEYNRLVEERRLLESERAQQQPQGPQVRPPPPSPPQQYPPPQQAYPSSGQQPQQSQQVYPSSDQQQPSNGQEQLHPAVLASQVVQCPSVNCAPAPQQRPPPPPAPACRSAACIPTRPPLGVWQEWSDWSGCSCTCGDGMKQRRRYCTTEDCGGGEAVETAPCSMGPCETWSEWCEWSPCSSTCGRGEKQRTRYCLLGTQMCEGKDFESEPCDAGPCPEWSQWEDWGQCSTSCGHGIQSRQRTCLGGTYGYQQCNGEKVEQRPCDHGPCSTWSQWQEWGLCSVSCGDGVKRRERVCQGGTDCVGESVEDIFCSGPPCAAWSVWNEWSGCSALCGPGQKIRSRQCQSPNGQATEDCLGDKIETILCNERECASWSEWCDWSPCDRECGGGISLRSRVCEAPGSPYGDNAQCPGPDRETRRCNEHPCAPQCQWTEWCPWSPCSALSACDTGISSRSRQCVGEPGCSCRGPAEESQQCQGTIPCTPPPPPQPQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXM4</accession>
    <name>A0A914YXM4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates sugar transport across membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXM4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5257.t1">
        <property type="protein sequence ID" value="PSU_v2.g5257.t1"/>
        <property type="gene ID" value="PSU_v2.g5257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF245">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5257.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25855" checksum="EB28B8AA5BAE8F51" modified="2023-02-22" version="1">MGLFEIFTAELMAFSVFFTFLPMVLIKQWKERGTAEGFTSVNFVLPMLMQACWFRHGWMTNDKVNIYLNGFNLIVFSFYIAAFAYYQPRRQYLIGQVSGLLISLFFLFSYVDQEPEDTKRHELMSGVAATTQIFSLLGGVYEIKRAVDLKTTEYIPAAIQFGIFLLVSQWTVFALLIGNYHMFLANLAGLAVNVATIALYFIYPPLTWKVPIFNIPPQKKKNENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY99</accession>
    <name>A0A914YY99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YY99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5476.t1">
        <property type="protein sequence ID" value="PSU_v2.g5476.t1"/>
        <property type="gene ID" value="PSU_v2.g5476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5476.t1"/>
        </source>
    </evidence>
    <sequence length="245" mass="26007" checksum="0F2DA72C45189D60" modified="2023-02-22" version="1">MASVSVPTVDAACTYTTDAMCTPTTLSVQFNAGPPLLMSPQTITCDTGTMQYTFDNAGTPTQVNSIDCACDVNPCPATPTGTRVILVSPPMADGNCEYTVQADCMKGDGALTVFRYNGAAPDVNGIQTWTCDPTTMEYTYDNAGTPSQINTVTCRCSTSKCFMTTGPGIAAPGPEPQDPTTCIFDRTFACDPGYTIAAFRQTPVAPYDLFPAPKQMRCPGGSGGNWQYELTPGVWVEADRGECRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ82</accession>
    <name>A0A914YZ82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4941.t1">
        <property type="protein sequence ID" value="PSU_v2.g4941.t1"/>
        <property type="gene ID" value="PSU_v2.g4941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4941.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25622" checksum="980CD25EE9A51CC5" modified="2023-02-22" version="1">MSRVIGDYLTMDVSSNNLQLLHLRHATSPFEDIIEMKLWEDYGEVYLDSGFFAEVIPILSHLLHPFTFGKTLKLESRDGASMAQWFSPRDNGFYERCLVEVESLNVHGKWQEDLLRSFIHCCLNLKKLSLTYWSCRNIHQILRSIPTKYLTDLTIQVDSTTNTTVEIMEALNEIGRVSPNKMERLMLFLNKEFNGEDPFRQYGQVNFCSNILHVFIYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0N2</accession>
    <name>A0A914Z0N2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0N2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5442.t1">
        <property type="protein sequence ID" value="PSU_v2.g5442.t1"/>
        <property type="gene ID" value="PSU_v2.g5442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5442.t1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30336" checksum="CCC831B4B2CDA6DE" modified="2023-02-22" version="1">MGQVKPNISNLSTSTIAGQGMYDEEDFLTILNHDVKMSLIGDPDYNSDEESGIMSIDDEIILVSKLEREAERQIRIQNDFREALNPNIGLELNGMYSDHKHVMDSIVRLRSDAIEIYNDSIVANHDKTLPPPEVLTYKYKGRIYKLVTLFQWMYSDDNTHLPSEHREKRVNKIQKFYLHLPPPAMLPMRKRLFNVMEIPASCSPQKMRKPSFNLTINGVKIGKSSSSKKTRGNLNTSEIPGTTSVKDLSHDAVIDKDNDDLGNSKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z243</accession>
    <name>A0A914Z243_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z243"/>
    <dbReference type="WBParaSite" id="PSU_v2.g678.t1">
        <property type="protein sequence ID" value="PSU_v2.g678.t1"/>
        <property type="gene ID" value="PSU_v2.g678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g678.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17282" checksum="C3DDF08BD3FE8CB6" modified="2023-02-22" version="1">MGKCLEKIGVKAGDSRDSDGHYRFFPFIPEHHLSPNHLSPKWFSTYIYYPSKEGPECCSDYAISFHYVNANLMYVLEYMIYHLRPFGTGTSVDSVQRYKTNSSDLLKTAYEMSISNMGPDDVFKKKVEDAEKLMNEQSLPNFPNNSTRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2H2</accession>
    <name>A0A914Z2H2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z2H2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4448.t1">
        <property type="protein sequence ID" value="PSU_v2.g4448.t1"/>
        <property type="gene ID" value="PSU_v2.g4448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038165001" description="Metalloendopeptidase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="54"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4448.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23097" checksum="304C0A9CC1B823E0" modified="2023-02-22" version="1">METRFFILLFFVIISLCIDVTQSAKGPRADIFNTQDIGQFRDISKSSPNGIAENALPFTSRFKWKTRDAYGNYQIPYIIAGPFKREEYRMIISAMVRIQANTCIRFIRRTNERDFINIESVDGEGCFAYVGNHGGRSSMNLESSGKASCMFHDIVIHELLHSVGLWHEHMRHDRDKYIKVHYENIARGKNSEGIYEIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2K8</accession>
    <name>A0A914Z2K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2K8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6588.t1">
        <property type="protein sequence ID" value="PSU_v2.g6588.t1"/>
        <property type="gene ID" value="PSU_v2.g6588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6588.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="54464" checksum="7E3FB37468055FD7" modified="2023-02-22" version="1">MSEKTILCFTPKLNDILLHIIDVGTFKEEIRVFSLSNLEDILQKLPSLPLDTVIGVLFRLTVNEIKEKSKLAKLLEEYYSKHNIALFCCTWNSIFISSIIMACIDEHGIESTPDGIFCIITCNEDNITITHGTNSKNIPNDESLGHNYYHIFSAQSLPSKNIKRDLLKVVKGTTTNIFVTCQKELHLQSITNEQKKIQKLVENTLQSKTITIINKNIHEFIAQAICYKVMKFFNLFFTPFDVANNGFYNYAIAPSKENITQLTSTSFNKCLVSVNAVEGIPFYNMIICYEKFQNLTFMKTIDQSLDVETLENFSVDEFGTSLIISIDRFYESHLIIEKDNKQIKNGAIICLKEKTFSVEIIKDGELKDIGINKIPLEVTIADGQAYYIGEDRLKIKKHSDTIVIPDLLKIMTSNIPKISPKKGVKIVKDDDGKILLEFETYLGRRKVNPSFIFSLILKWSVRQAKMKLRQMPQMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z318</accession>
    <name>A0A914Z318_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z318"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7092.t1">
        <property type="protein sequence ID" value="PSU_v2.g7092.t1"/>
        <property type="gene ID" value="PSU_v2.g7092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7092.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17415" checksum="45A6A53798BE59F8" modified="2023-02-22" version="1">MIFKLLTAKNNALESKMFTISEENTELTETVEKLQKLAEKNVPQKPIETPLNVMSESFVTDYNGLQDKVDELNEDKITLEAKVREMENFMKEMVQKLEELESVNAELTEALSSVNNKKQQLLEENKYMAESVTTMQMQLDTLGTPQKIKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3F7</accession>
    <name>A0A914Z3F7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3F7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g723.t1">
        <property type="protein sequence ID" value="PSU_v2.g723.t1"/>
        <property type="gene ID" value="PSU_v2.g723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g723.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21501" checksum="802196BDD165112D" modified="2023-02-22" version="1">MEKGMAIQSGNDAAIALAEHVAGSEEAFASLMNSYAAKIGMKDSHFVNAHGLTAEGHHSTAYDLALLGRAMVRDYPETYAYNKIKEFQVGNIKQPNRNLLLWRDGSVDGIKTGHTSEAGYCLMSSAQRGDQRLIAVVLGGASEKQRADDSLALLNWGFRFFETHRLYEPGKAVAEHKVWKGTTDKVQLGWPSRCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4C2</accession>
    <name>A0A914Z4C2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4C2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7203.t1">
        <property type="protein sequence ID" value="PSU_v2.g7203.t1"/>
        <property type="gene ID" value="PSU_v2.g7203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7203.t1"/>
        </source>
    </evidence>
    <sequence length="746" mass="81734" checksum="E28D5B3D76B49CAF" modified="2023-02-22" version="1">MPDTKEERECITPESIEDSCIIQKEDLQNGYCRSDSLVSKEEQEDNMDKGNDSDSSSVINQDMDEMIVVTKKRRNRIKNNVDNNAGQLPAAPTHSRSLPGTRSRGSDRQRQRVSKSNNDSKLKPLKISTASFDMDQDFPPLNSHPLSATIRREKVQSPPKNVDKVPVHPSKSDSNLAASSKQKLQEAFVENQVLLFSENFSNAVEEITNEDEETNVDKKMEEKVDEQIEKENQQNVKPSKEQCEVNNFECETDAVDQPSEQPGPSYSRNKGRRSGDRRSRSQNTFTSQNNQKHRPRFINSNAGPRRLRYPAFKNYSNNFGYMNPMMNVPYISSTQTASGFPFVYPSASSHGYGYAQLPSLYPYAPTGFVPHQTFLPMHLPYPASNFERFQGPSFLTQYPRGYPVPANGAPPGITKFSGNKNVSSSSTVVSNENDDKSSANVSPATTPVADYNGQRAPSVPVTLSASSRPFGENVKNIDRGHLSTPSAPATTEIAFNIPSSLPYGTAPISAVDSTMAKIADTNISPLSQSPESATSSTTHHATTTDSSNSDPSLVNPSCPRSIDTLTLSPELQKTVCEAFGLQSNEGIFYIYATDEKGEHTRQMRVILHNKTPIKFGKFASPVYLSPTVGPAGVLSPMGFYYAKQEKFSVPSSEGHPSVVHTVTQHHPVLSFSATIPEQYQIPLMPTYYQDVIVLPTPPPPTAPVLSSNPASTPPSTPLILEPTSSSKLSPSACELSSTSSNDTSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4E6</accession>
    <name>A0A914Z4E6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stc1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4E6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7226.t1">
        <property type="protein sequence ID" value="PSU_v2.g7226.t1"/>
        <property type="gene ID" value="PSU_v2.g7226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7226.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14525" checksum="2164B4FFA6F9B11B" modified="2023-02-22" version="1">MFYSNISAVAASRPIVPVQPGLDIPSGPSSPASSRSKSEARRCNFFSSSVVEEAGIGAPGPSQRADWAAPVPKRKHMKQRATRALHTCYFSGDGRPSRKVKKQTCLDCGEPKPDDFIDLDSPDDADNLDSSDDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4V9</accession>
    <name>A0A914Z4V9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z4V9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g529.t1">
        <property type="protein sequence ID" value="PSU_v2.g529.t1"/>
        <property type="gene ID" value="PSU_v2.g529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000002">
        <property type="entry name" value="Alkyl hydroperoxide reductase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="12">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g529.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19861" checksum="B7C4267D8ABDEA3F" modified="2023-02-22" version="1">MMSLINTQIQPFEANAYHNGEFIKVSDNSLKGQWSVLIFMPAAFTFNCPTEIEDAADHYAEFKKAGAEVYIVTTDTHFSHKVWHETSPAVGKAQFPLVGDPTHQLTRAFGVHIEEEGLALRGTFIINPEGVIKTLEIHSNEIARDVAETLRKLKAAQFTAANPNPGEKTLTPSLDLVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5N4</accession>
    <name>A0A914Z5N4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5N4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5567.t1">
        <property type="protein sequence ID" value="PSU_v2.g5567.t1"/>
        <property type="gene ID" value="PSU_v2.g5567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="47"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5567.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32635" checksum="4750082B9FC27CC9" modified="2023-02-22" version="1">MPRWDSVFTKIKRPLIVVLLPFLLSSIYFISQTKASVCACVVIYMSILWITEIIPMAATALIPMVAYPVFGIIEAKELCFEYLTDANFVFFGSLIMAIGIESVKLHERIALMILMATGTNPRWLMLGFQVSTAFLSMFMSNTATSAMMLPIVTSVICELDYCRRRHKKGAENVVKRDIEEICFKDSKEKDRNTYKCLLLSICFSASIGGIATIIGTGPNLIMAAFLDDDPNEKEIEEVLHQVLEKKYTDLGPIQYSEKVISVLFASMVLSWFFRDPKIFPGWGYLFPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5S9</accession>
    <name>A0A914Z5S9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5S9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7302.t1">
        <property type="protein sequence ID" value="PSU_v2.g7302.t1"/>
        <property type="gene ID" value="PSU_v2.g7302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7302.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30795" checksum="1DED93D4201C3D94" modified="2023-02-22" version="1">MVGLTRYDGNSLRPVRTVGDPAISIFPRVSLPGDGHLHEMNLLNRSTAINPALQPPPGTYGHQAGQIHQGFLPGTTTIVDDIDPDWESILHNIQEIGIHRFLTIIKKVPAIGLLLISLWIVWGRGFNTVLEDVEKNMGIVGLVSGGITAVGVTLTAQHHSNNKNSAKYQTWRRIIVCSLNFLCSIVVIVFGVISLSDLHGKKENNPKMTFGAPRMTVNERTAHAGALTGVGLLIAIFSLLSMAFGISALMKVNKAEHKVKQAQRRQRSVEYLNPAYGTVDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z706</accession>
    <name>A0A914Z706_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z706"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8110.t1">
        <property type="protein sequence ID" value="PSU_v2.g8110.t1"/>
        <property type="gene ID" value="PSU_v2.g8110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052499">
        <property type="entry name" value="C.elegans_NHRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47630">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8110.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23834" checksum="DC25259ECAC153EB" modified="2023-02-22" version="1">MITPTGSTIAILSDTTHDWKRCFVLYSDWIRALPDFQLFSPADKIALAELRYPAFHWWLVANWTIQTNCDGVCYCNGTYFPKDPSLQCLFDQRKCVERMFSLLVKPLKEMNISEGERILLGILTIFCSDTNNMSPEGRQILRKIRSRYIEALRLHLIHRGGMENEIELATRIGSQILMIASISLMNCEVNEIPQLRSFSSFSMMGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7S2</accession>
    <name>A0A914Z7S2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7S2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7947.t1">
        <property type="protein sequence ID" value="PSU_v2.g7947.t1"/>
        <property type="gene ID" value="PSU_v2.g7947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7947.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40803" checksum="44DEDC4B3154DA75" modified="2023-02-22" version="1">MLDLILLTLFVIFIFHQCYWRRLHLPPGPTPLPILGNLLSLDANDIDNQLIEYKKQYGNIFTVWIANATVIVGGHEAMKSIFIKNGDKVVGRTNFVVLEDIFGGMLGIANASDSLWKNQRKFFLHVLRDFGVGKPVLENAIITQASDVCAYFKSLNGTPISLTKIFSTCVGNIIYQLMFGTTVNLEDDSIYKNRNDILEISKVFHHPFTLLATIWEPLKYLRVFAGPSYHDKIKISKNMAEYFTKQIVEHRGTCDFDGEPRDYIDAFLIEQRKQNPSLNEGEWSDRQLVAIMFDVFSAGFETTGTTLEMFILYMLYYPKVQTKIHEEIDRVIGKDKTITISSTNCYRNTAKFISSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7V2</accession>
    <name>A0A914Z7V2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7V2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7979.t1">
        <property type="protein sequence ID" value="PSU_v2.g7979.t1"/>
        <property type="gene ID" value="PSU_v2.g7979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036734993" evidence="2">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7979.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="16082" checksum="B6409602CEC4836A" modified="2023-02-22" version="1">MNLMLIFGIGILSFQIVVGQFFNDPVVNQYSGHPMQIILDKPPPKLYDSQEVTEKDLLKIISASQKGQNDGGKQGGGGGGRKGGKGKGGGGNDGSDEDEGLAGNLGSLIEMFSGGKDDDDSGSNEGVGDIFGDLIGGVLGGGGGKGGSGGDILGGLIKNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7X6</accession>
    <name>A0A914Z7X6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7X6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8789.t1">
        <property type="protein sequence ID" value="PSU_v2.g8789.t1"/>
        <property type="gene ID" value="PSU_v2.g8789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8789.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="32992" checksum="5135D70A0B894D1B" modified="2023-02-22" version="1">MCRNPSIKGKILHEPDQKSNINGVDKFLDVIRNLFPDNLMEATFRQISTEYVRVNISDPESPEVLKIKKSDGMNILGIIVVCIGVGISLSYLGDKGKPLADIFISLDHVIILLVRLLMWYAPFGIASIIAAKIIEIKDLTKTFQSLSIFMGTVILGLFLHLFVTISIIYFIASRKNPFKFFKGLIQAAINALGTSSSAASLPITFQCLEKNGISSAFTKFVLPVGAVVNMDGTALYEAVAAIFIAQINGINLSFAQVITVSITATLASIGTAAIPSGGLVTLVIVLSSIGLPVEDISIIFAVDWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z897</accession>
    <name>A0A914Z897_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z897"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6476.t1">
        <property type="protein sequence ID" value="PSU_v2.g6476.t1"/>
        <property type="gene ID" value="PSU_v2.g6476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6476.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17505" checksum="8F44D8CDE7FAD0C5" modified="2023-02-22" version="1">MNNLAQCYFAAEGTGSIVPTDEDIAEGMKWLKIAAENGDMVSAKEFERRQNLTPTEAKVESMKDFFISTSGLGPKVNHLDEKQFRKEVEKAAKNGSIIAQRQLDIWVNLNIAMESFRNNDSARLFAALSKAIRLHHQLVEVPEIFKPIILVRFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8M5</accession>
    <name>A0A914Z8M5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8M5"/>
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        <property type="protein sequence ID" value="PSU_v2.g9026.t1"/>
        <property type="gene ID" value="PSU_v2.g9026"/>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
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    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9026.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15376" checksum="96432FAC729E085C" modified="2023-02-22" version="1">MSVARKVTSYFARYSRKEWMDYFLSTHFWGPVANWGLPIAALRDLKKDPEMISGNMTGALMLYSSVFMRFAWHVKPRNLLLFACHVTNFSAQTGQMARFLNYHYLHIVEDPFYSAVAPPPTPLPTDALPLMAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z928</accession>
    <name>A0A914Z928_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g8424.t1"/>
        <property type="gene ID" value="PSU_v2.g8424"/>
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    </dbReference>
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            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8424.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7428" checksum="F6D2978746EE3461" modified="2023-02-22" version="1">MDVEDVDDWKLKEGVTCLVIDSGCRILAVIGSLTPGEADGRRYCVLEADDKGDPFRLSSSNKFSLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9T5</accession>
    <name>A0A914Z9T5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flotillin</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Panagrolaimus</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g701.t1"/>
        <property type="gene ID" value="PSU_v2.g701"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g701.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12546" checksum="C4AFA172B0C5A90A" modified="2023-02-22" version="1">MDVANITRERISIDKTVAQEEERIKEVREVSEADRQKQVLILEAEAKAQESLVREVKEAQARETASKHRAVELTTLAQAEHEAAGKQAEAKRLLADAYRAEQAAPGLAEAQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAL2</accession>
    <name>A0A914ZAL2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g7289"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7289.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="32337" checksum="D6DCC8CB748A5B85" modified="2023-02-22" version="1">MHFQLNKSNIFQFNLKWKIGLWKTIKAQKDFVAEYKEHFFIFKFVQKENEEFLITIEYSPSDLALIKTVNCLWNCDFKNEDSNSDSVIVTNKSFSNFEISSPVTILHGNFKDVAENLILTFEFTSTYSFITLANIGLPNIDYSKQMLKEYGIKPNCNVVVNEKSFKVHNFMLTAGSDVFEAILNSTKNQKRIDIPDFEPAVVKDAIKFIYGQKPPQAYYQLYRFSTLYRIRQLMDFCELYFEKNLGPNNVIQIYQQSVENNRGHLRHFCVVFYKK</sequence>
</entry>
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    <accession>A0A914ZAT8</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g8880"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8880.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16304" checksum="C375C8527420A53C" modified="2023-02-22" version="1">MMILRIQLSQFRPPEKHVCKPRSLKEVREQQRTFEKKGRKRERIVDDNYESEVEGPQEIKRTRKSAQIATEKLTNCFKDCDNIVTENDESNIEEPENNKRILRSARFNDSKFKSVASDDADGEEKSGVSKPTSKIRTNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBG1</accession>
    <name>A0A914ZBG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g9262.t1">
        <property type="protein sequence ID" value="PSU_v2.g9262.t1"/>
        <property type="gene ID" value="PSU_v2.g9262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9262.t1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38118" checksum="02EC0EEA5E3FC11E" modified="2023-02-22" version="1">MNSINCTTKEQCPETTTNCRRELQALLHEVNRQLWHSYKTDPEYLADADLYTITILCLFASVILVLMVRSIKPSESIDDQVTILLNSMRVRVEFEDNARQRQKLREAKRKAQRWLAEAKQKSCKKLSFSGSFRLRTKSDSDALQQQGTSSITDECQPENISMKSNPIQITTPSTSTKTRKKSSSTSTTAPYHHQHQHQHQQQHQHTSISISSSIPTKSMTATTKTFPRKPIIYQRAASYQFLPEIVVTSTHHNEDPPPPLSATTTTTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQQPQQRQKDIIGNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBR4</accession>
    <name>A0A914ZBR4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZBR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7691.t1">
        <property type="protein sequence ID" value="PSU_v2.g7691.t1"/>
        <property type="gene ID" value="PSU_v2.g7691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000023">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000030">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000027">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000042">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF240">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038155629" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="343"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="53"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="394"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7691.t1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55080" checksum="18ABBD05CAC4F347" modified="2023-02-22" version="1">MLKLVVALLFITAFAYAVDVEEEDNVLVLTKDNFDGLIKEHEFLLVEFYAPWCGHCKSLAPEYAKAATQLKEEGSAIKLGKVDATVHSDLASNFEVRGYPTLKLFRNGKPSEYGGGRDQASIVAWLKKKTGPVAKELKTADEIKDFQDSADVVVVGYFKDADSSDAKVFLEAAASVDDVPFGIVHEKSAADGAEFTKEGVALFKKFDEGRVDFDETLAADKIKAWIQASRLALVSEFSQETAPVIFGGEIKSHNLLFISKESPDFDKLLGEFRAAAKDFKGKLLFVFINTDGEDNARIMEFFGLKKDDLPAMRLISLEEDMTKFKPTFTDITTENIVKFTQDYLEGKVKPHLMSEEIPEDWDKNPVKVLVGKNFDEIARDQSKNVLVEFYAPWCGHCKSLAPTWDKLAEKFKDHENIVIAKMDATTNEVEDVKVQSFPTIKYFPANSNKVVDYSGDRTLDAFVKFLESGGKTGAGLSDAEKAEEEADDDEGHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBV5</accession>
    <name>A0A914ZBV5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9806.t1">
        <property type="protein sequence ID" value="PSU_v2.g9806.t1"/>
        <property type="gene ID" value="PSU_v2.g9806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000188">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF190">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1082"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1122"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1147"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1197"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="969"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1238"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1323"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1323"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1340"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1425"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="623"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="917"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="923"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="943"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="946"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="947"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="947"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9806.t1"/>
        </source>
    </evidence>
    <sequence length="1453" mass="165896" checksum="80968591075B6970" modified="2023-02-22" version="1">MAEIFSNCFGNGSKKRNNSNSSQSEIVGEQERVLKANDRTFNAQFKYADNYIKTSKYNVLTFIPKNLFEQFQRLANFYFLVLMILQFIPWISSIVWYSTAIPLFIVLAFSAIKDGYDDIQRHRSDSQVNSRISYIVRNGRLEEEKWMNVKVGDIIRMENEHFIAADLLVLSSSEPHGLCYIETAELDGETNLKTRSALPETVSLGDIVRDISNFDGQIHCEAPNNRLDRFEGKLTYKGTPYPISNENLLLRGCRLRNTRWCYGVVVFAGRESKLMMNSGKTTFKRTSLDRFLNILIMGIVLFLIAMCLICTILCGVWEWVTGRHFTDYLEWDRTIVPNPEEKGSRQIAIISFLMFFSYIILLNTVVPISLYVSVEILRFVHSLWINFDTEMYDEKMDTSARARTTTLNEELGQVQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVYTPRGEQVDIDENTPSIDFSYNRWSEATFKFYDKTLVDDTKRKITEVEQFWRLLALCHTVMPERKAGSQLEYQAQSPDEAALTSAARNFGFVFKSRTPQSITIEVNGKEEIYEVLHLLDFDNVRKRMSVIVKDRKGKIKLYCKGADTIILEMINPNTSSLLKDATVKHLDKFASDGLRTLCVAYKEIEESYVREWLKRLKEANLDRYNKDEKVDKLYEEIEKDLNLLGATAIEDKLQDQVPQTIAKLAAANIKIWVLTGDKTETAINIGYSCRLLTEDMKEIFVIDGKTEEEVEVQLKDIRRRIERGTSQPLFDTMSIDSDDSVKRYIEEQYQILKTHREREEEIANKNRDNPNLPSPTGHIRLFEPTNAPGNSAFYDNTSRGPNYNYNIAQFHSEPGSIPTITTNDVVLPKPKEQQQVPVEQSREEDPNLPPQEGFALVINGNSLVHALKPKFERMFLEIGCLMISVICCRVTPLQKAQVVDLVKRNKKAVTLSVGDGANDVSMIKTAHIGVGISGQEGMQAVLASDFSIAQFRFLQRLLLVHGRWSYFRMSKFLRYFFYKNFSFTLTHFWYSFFSGYSAQTIYDPVLISCYNLFFTSLPVLAMGIFDQDVNEEYSLAYPKLYIPGQYNLFFNMRIFIYSVFHGIASSLIIFFVPYGALFEATDHSGRDMNDYPMLAFTTFSALVVVVTGQIMLDTAYWTVFTYVVLLGSLAFYLGLVIIIYEVMPVKFIANTVASMSYGVVFRALSSSQFWFSLLMVTVVLLLPIMLNRFFWFDTHPSYADRLRVRHKLPKDARGKEVPSKQLPRTAVTRRSRRGSLRSGYAFSHSQGFGELIAKGKLFKNIEHLRMPSNRSSPTKKGLAPIIETPPGLIAAVATVPQSNQQSRPTSRDESRSQSVMSTPHSIIVNQDDEPLPSFLRNDNPSKPAHPGYTSATVPRQTPREVPTHFPAYPPNIPPTSNAHRRQSNHDHVISSPMPLPASSNSSTSSASQGPRFVGRQRRQHLETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDP8</accession>
    <name>A0A914ZDP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDP8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g84.t1">
        <property type="protein sequence ID" value="PSU_v2.g84.t1"/>
        <property type="gene ID" value="PSU_v2.g84"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g84.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19525" checksum="6F0CADFE1B019104" modified="2023-02-22" version="1">MPKVNNIDDSPMIKHMESEESGNFFNSINDQTYNVRNSPTSHHPYLGEGVAVVEFPEENQQQNQQHQSRQNLNFDGLRLLPPPSPTTTTSTPTPTTTQKSIGKKAVQLSPINEETASSMNSDECNPRQDCCPLVDMSNRKGRGCTLGYKINQYNQQEGCVPESCRNKIPSEFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE91</accession>
    <name>A0A914ZE91_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hint domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZE91"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8589.t1">
        <property type="protein sequence ID" value="PSU_v2.g8589.t1"/>
        <property type="gene ID" value="PSU_v2.g8589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hint" evidence="2">
        <location>
            <begin position="275"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8589.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41193" checksum="245D65149EC52D92" modified="2023-02-22" version="1">MKEFYSFTNETAECEDDFSSSKCMGDGEWVGGIKEQNDIGSDEILFRCCYHSKAKTAKFLTVYDIKINEKFEGGEVFDDDTGEQLFFDYINNIVKFVTDKGLINYEIFVNRLPCIPLQKSFKKMIESNATIYSNNIKESSRIDTTKLFQAPTFVAAGEFLPIVDGGSSIPMQSAIPPPPSFMQNNAFANVNNDLQIPQNPQLQSPIQNNLQVTPINNNNAFQVAPLQSFQPMNNFVSFIPNSNPSVPVPSSGQASYPYPYYNYYPVETANPLLRFLCFSGDTIITALNGQEKRLDQLEINEWILSSGENVAVGYSKVNAWIHRMPKVEAEFIKFILEDGKELKITNKHFMYRGDCSRKFFYPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGA3</accession>
    <name>A0A914ZGA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="PSU_v2.g9315"/>
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        <property type="component" value="Unplaced"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
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    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="568"/>
        </location>
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            <end position="135"/>
        </location>
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            <end position="190"/>
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        </location>
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            <end position="325"/>
        </location>
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            <end position="382"/>
        </location>
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            <end position="512"/>
        </location>
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            <end position="44"/>
        </location>
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        </location>
    </feature>
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            <end position="267"/>
        </location>
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            <end position="292"/>
        </location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XU16</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10747.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="9968" checksum="DCA9E45CB1170793" modified="2023-02-22" version="1">MHLRLEKTHFTKNYFSEKGLPGFQGERGHPGAPGTDGPEGPLGAPGMQGAEGDYGDAGPKGVRGVRSLPGSPGRPGNAGLDGLIGSKGESGIPGCNGTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV06</accession>
    <name>A0A914XV06_9BILA</name>
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        <submittedName>
            <fullName evidence="9">DM domain-containing protein</fullName>
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            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
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            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
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            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11772.t1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19192" checksum="15A9C4DF956A8CEB" modified="2023-02-22" version="1">MLKCRKCAAHEIEVPVRGHARTCPYRMCSCDKCVKVVNKRLSSVKRRYKNSDVVFVNIECNSGNVRVQAIPKTLIDTLKSNKDCQLTSSTSSSSNDKTESTKEISPPPPVLQTPLESQLSPSPPLIEPSLLLNMMQILPYFRMSAEQQLNLISTYAWILQSAKYMEEIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVJ2</accession>
    <name>A0A914XVJ2_9BILA</name>
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        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVJ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11959.t1">
        <property type="protein sequence ID" value="PSU_v2.g11959.t1"/>
        <property type="gene ID" value="PSU_v2.g11959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000145">
        <property type="entry name" value="Chromaffin granule amine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11959.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="37748" checksum="A12316E345088B54" modified="2023-02-22" version="1">MTQEQRDKYMEEQRQHRHETLSEENVHVGLMFGSKALVQLITNPFIGPVTNKIGYTVPMFTGFVVMFLSTLMFAFGSSYGMLWFARALQGIGSACTSTSGMGMLAQAYPDDAERGSAMGIALGGLALGVLIGPPYGGVLYGWAGKELPFILLALLALGDGTLQFFALQPKIDRGEPEGSGIKTLITDPYIIVAAGSITIGNLGIAMLEPSLPLWMMESWQASSFERGAAFIPASISYLIGTNIFGPLAHKIGRWLSGFIGLVVIGFCLLMIPSAESVKGLIIPHFFMGFSIGMIDASMFPMMGYIVDKRHVGVYGSIYAIADAAFCFAFALGPFFSGPLVRSLGFGGFELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVN1</accession>
    <name>A0A914XVN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11997.t1">
        <property type="protein sequence ID" value="PSU_v2.g11997.t1"/>
        <property type="gene ID" value="PSU_v2.g11997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11997.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32958" checksum="EB50D0824391D133" modified="2023-02-22" version="1">MDFDFFEFYLLPEVCQWQFFETLSPLTLQRISTVDKYFNYLANRQLKTCLNRITINANVHIKFDKNGDITVINDPTVFNLNFDENGIRNILNKIESCFPCKVLQLQKSDKNDEINNVAEICEKILNYYIFTFKTLTEIRFESINLNSTTLLTTFINAPNLHTVNLSNITFDQSIQFADILSYLPNLRDLSLINVSSIKYDTDSLSLLVKHSKTKSLLKSVKIDPFEEIPNEDDFEALLRSVTKEIEIIWKPNINDLAKFFPKDFIDFCVDPFYTIILHRKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVS3</accession>
    <name>A0A914XVS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1063.t1">
        <property type="protein sequence ID" value="PSU_v2.g1063.t1"/>
        <property type="gene ID" value="PSU_v2.g1063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF174">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="150"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1063.t1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39117" checksum="6D573A89F8502C48" modified="2023-02-22" version="1">MAGLLEESNNLLSEAATHPEALSTTRFWHKRLTLTGHAKPRTPVPWMILYMIIDVGTYMLTIVSFYYLLTRYLILPVERGFYCNDPEIRRPFHENTISTTLLLIITLFFPYIIIFGDFWIRKDLFSNGRTLFQSIFNPSFQTCRSTCYVYLDYVLSFGILTYLLEIVKCYTGRLRPNFIQLCKPSTLFECEENPLGYITSFICQTSFKHSRNSRLSFPSGHAAASIFSLLFLAYFLQRTERKLLAQFHDAKKQQQQQRSSKTTDFKLRLKTKLSMLYTKGMIAMYGGFCVICCASRVLDNWHFMSDVIGGILFALLSFFILLKSYTKIGKPINQKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWB1</accession>
    <name>A0A914XWB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PEP-utilising enzyme C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWB1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12224.t1">
        <property type="protein sequence ID" value="PSU_v2.g12224.t1"/>
        <property type="gene ID" value="PSU_v2.g12224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000010">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030:SF1">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-utilising enzyme C-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12224.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27587" checksum="467D035ED73462FC" modified="2023-02-22" version="1">MKGFDSPREFYVGRLTEGIATLGAAFYPKRVIVRLSDFKSNEYANLVGGERYEPDEENPMLGFRGAGRYISDSFRDCFALECEAVKRVRNDMGLTNVEIMIPFVRTVDQAKAVVEELARQGLKRGENGLKIIMMCEIPSNALLAEQFLEYFDGFSIGSNDMTQLALGLDRDSGVVSELFDERNDAVKALLSMAIRAAKKQGKYVGICGQGPSDHEDFAAWLMEEGIDSLSLNPDTVVQTWLSLAELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWS3</accession>
    <name>A0A914XWS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XWS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10212.t1">
        <property type="protein sequence ID" value="PSU_v2.g10212.t1"/>
        <property type="gene ID" value="PSU_v2.g10212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF113">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10212.t1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48584" checksum="C6D621DFEDF10BCC" modified="2023-02-22" version="1">MDNSLHVSKRFSTLCEYVDFKTQLLPSLTVEQLLHYHARLALNCKSDTVNYRVFTLMQQFDLGPIADRTLASLREADRRRLLIAMHLVKDPVLIVIDDPIKGLDALSAFQLMSSLQDYTKRQARMAFITMRCPRSDIYQLLTQITLLFYGEIIYSGPTKQMPHYFSDVCMLQCPPRENPPVYYLSLASVDRETPESYAETHTKAMKLVEIFRDRKDSIGYLCHNLPPTTEMPILSSFYGVPSTISRFTTLFSRHLSHIGRSPSFCLAQIILPFLILIISIFGATVTNKSWHIPKSINGTFFSMTLFTALASVSYGSFLSLSYYLSYLTIPSIERFANIRAAFEFVNSTIVSNCTRNEFKNFTSLDSFCRWTKGNDYIREIFPDNITVPEWWNGPLIAIFAFLITSVFCVLITQKCAYRKSGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXA3</accession>
    <name>A0A914XXA3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914XXA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12582.t1">
        <property type="protein sequence ID" value="PSU_v2.g12582.t1"/>
        <property type="gene ID" value="PSU_v2.g12582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="12">
        <location>
            <begin position="450"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12582.t1"/>
        </source>
    </evidence>
    <sequence length="612" mass="70712" checksum="E9C0B597A963659E" modified="2023-02-22" version="1">MPLLLLCGIPGAGKTTIAKKISENLGAPYFSFDDFIETQLQQPSTASCFSNDICAHLPKPITDNKEEEDLLKPMKIYRKSWENSIEDYLNQLITMGVSNPFILLDDNFYLQSQRRDFVKIGKRFGLKICSVKVLVDVKEAQKRNLERNNCKTDKRMLPKRLWINSEIIKKMDQKFEDSGIDYFYNSASSATANIFTFIQNFQKTYPDNFSMTKTTVPDSQPEHDESAIQAIDLLSREITSRIIASGYQRRGKEINDIRREFVETFKKKKLYPNLTADIVKLYSYFYLSRLSRRLCDMASDQIIQPCCSTTSEEPTTNFIKCDSKELNLDVVLLNGQSFRWKKDNNNDESEKLIGVACHRVWKIWRIDENQIAFQVLAKFPQAKVFSGESKDDEEVLKDYFQLNVNLSTLYTDWQTLDPHFSSIFQSNDKKFEGIRILQQPLLETIFSFICSANNNISRISNMVNTLAELYGNKITVKMEKDEKIQDFYDFPSIEQMENGLNGMEKILREKGFGYRAKYIAKSVETLSKIDGGFKNWEKKLKEMEYGNAKIEIQKLDGVGPKVADCICLMALNQHHVVPVDTHVFQITALHYLPELKKSKSVTDVIYKRIILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXB1</accession>
    <name>A0A914XXB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXB1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11171.t1">
        <property type="protein sequence ID" value="PSU_v2.g11171.t1"/>
        <property type="gene ID" value="PSU_v2.g11171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498:SF1">
        <property type="entry name" value="COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11171.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20193" checksum="D2094B18647BE3CC" modified="2023-02-22" version="1">MIKDYLINKWGLSKDEFTDNQNWPYALYVREARRLVGDFVMTQKDVIETDLTKPDPIGMCSYGLDVHPVQMYADPIGTLIYEGELDTEADREYWRSTGNSICQIPYRILLPKKTEASNLLVTVCVSASHVAYASLRMEPQYMIMGHGAGVAAAMAVKNGQNLSWNTLYPLYPLLRHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXH0</accession>
    <name>A0A914XXH0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXH0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10446.t1">
        <property type="protein sequence ID" value="PSU_v2.g10446.t1"/>
        <property type="gene ID" value="PSU_v2.g10446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038164686" evidence="11">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="93"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="318"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10446.t1"/>
        </source>
    </evidence>
    <sequence length="510" mass="59279" checksum="AE429025F59A3F44" modified="2023-02-22" version="1">MILLSLIFWIAGILPTLIFGQQDRLRQESLETYYMKVYRQNQAIMSNLKQRIQKENPNAYLPTSQPYTSGRSSDGPLLSIESEDSQCTSDKVIIEKLLANYKTHKTPSELGVIVWIEVWVQEVNAINEITSDFDMDIYVTELWVDYALKYEHMNPCKNNLSLNNEILEKIWKPNTCFINSKSANIHKSPFTNVNGTVWINYRVQVRGPCAMDFSTFPIDTHQCFLTLESFNYNNQEVDMRWLKSPTQPPLTLLKESIELPDFVLTNYSTFMAHVVYPAGIWNELTMTFTFSRRYGWYVLQAYIPTYSAIFISVYKYFKPRVSYVKALDVWMLSILTFIFASLLELAVVGSLVAKQDKRAAAASVQDIRRPSMMSINNVLPPSASPKLCRHNAGNRETSPHSCRLYGSTNNDPRTRRRTFFSPTEGILSSPMQTRQTEQMLLLETKDNFNQPKSFKEKIVRPLRRWKARQSEPWTTEQVDRFSIYAFPTAFAIFNIFYWGYYLTRPVILQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXN4</accession>
    <name>A0A914XXN4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g1197.t1">
        <property type="protein sequence ID" value="PSU_v2.g1197.t1"/>
        <property type="gene ID" value="PSU_v2.g1197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050059">
        <property type="entry name" value="ATP_synthase_B_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33445:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33445">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT B', CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1197.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24661" checksum="83DDD387CC19E114" modified="2023-02-22" version="1">MSRVVLPRIGGVIETRRDRIAQDLEQAARLKTDADNAIAAYEQELAEARKSAAVIGQEARDKAKNDIDAERKAVEASLEKKLAEAESRIASIKEKAMSDLGSIAEVTTAEIVEKLLGGKSDKAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYGRNILGPDWSGHFPRDLSLSQSSGYDGSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ39</accession>
    <name>A0A914XZ39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10941.t1">
        <property type="protein sequence ID" value="PSU_v2.g10941.t1"/>
        <property type="gene ID" value="PSU_v2.g10941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10941.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13108" checksum="165B0F7E27E777B9" modified="2023-02-22" version="1">MFMESNALENPYGFAPKSCFASVFPNEPVHPGTNFANYNLSNTTLSGEAGPSPQVSQSQPSSSSSSSSSSSSSSSSSSSSSSSTPRSQANYRLVKFEPYSETIYEENDETADTSADEKEENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZF2</accession>
    <name>A0A914XZF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
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            <end position="492"/>
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            <begin position="254"/>
            <end position="268"/>
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            <begin position="514"/>
            <end position="523"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12340.t1"/>
        </source>
    </evidence>
    <sequence length="555" mass="61939" checksum="FD4DEF64FA1DCDE3" modified="2023-02-22" version="1">MASKRHRLSLSPPTPLKSSSSATTSTSSTSHEEACFSALILQAAAIQTLKEMMGETDWRMTTPSTINRGQQILSRFAETNNFSSKSPASSCYQSSSNNGSGIPKKRLSHAGAMINGMHSNDLSSPSTSSSSNSSTRNAMLLNGRNGNNAGGGNVDFSTSNSSSSISGINYNKRGAAYKRFTLPSIMTTSDSNSEISEPISLDPIDYHYLYADEAPIDSMTEEHQQQQQQTQQPRQRRQRRNIGSLDSNMPLTHEEDDDDDIDDEENEEENHINDDGLRFKNIAVREIQQDVKKVGHKFGGFHPSVRRVASFTSPPTKTQIAKAAEKHQREQRRGFLGKTLHFLRNKVDTTLSQPSLIPTREEVKSWHEKMENIFESKFGVMIFREFLEKEFSAENLDFLLKCREYQKLFENEKKNSKKIARHAKEIYDDFIAAEIAPKEINIEAQIRASTKAAVNETLKENTFSLAKKQIQTLIENDKYPRFLKSQEYQNLLQSVTLGSQCSIQSALPELPFTDSDSSSTPCHTGNEDTPLAPANRTLRSASALETLGSISTINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0H0</accession>
    <name>A0A914Y0H0_9BILA</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A914Y0H0"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Armadillo"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11362.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20039" checksum="C3BC6B979AA18718" modified="2023-02-22" version="1">MDKLLMHPKEKINKEAVWFLSNITAGNEGQVQAVIDAGLIPLIISLLDRGDFQTQKEAAWAISNVTISGKPEHVLFMVDMNVIPPFCSLLGIRDAQIVQVVLDGLNNILKKAGNRTEEICQKIEECGGLDKIEHLQNHENEEIYKLAYEIIDAFFSSEDDDVEQDGHFNEAQGAPGGFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0H3</accession>
    <name>A0A914Y0H3_9BILA</name>
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        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
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        <property type="gene ID" value="PSU_v2.g12710"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:nuclear receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
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        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="525"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="773"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12710.t1"/>
        </source>
    </evidence>
    <sequence length="817" mass="90753" checksum="D4D3C71EE0D75964" modified="2023-02-22" version="1">MITPDDPIIHSPPSLRPIALQQNQGYNMGCQQQQNDIQQFNPLSRPPPSAAPSAGPPQSYESPGSFQRSDSLSGDESSSSRSKRSKLCRVCGDNATGYNFNVITCESCKAFFRRNANRLRKEWILNEDQLKRRKNSRLNHTMKSSCGTRTSPPQQQQKRAYSPNLPPSQPKLISQLSPQSKVAKQEKLVRNASASMENSNSMINGVDRMNAGAIVNRSFSVQSSMDLTSPASINASTPVSLSMMSPVNSMSPSSSSPISTSTPPQMSPKVETLSPMKLLTLNEIIHGFQLHISPQSYQMPSPSNTQTVKVVVQSLRLFSPQMIQYFGCGDFVRVLLPITDYAQLITVCGNNLNQTMELQNGDIRLPDEAYEPLKRMIDEYTNRSLQLQHPQQQQQQCSPIIPQQPPAAAFPHSQGVAVPTTPTLASPNFHSGPLAIPTSDGYTPNCNEIRTTTILTSTIPQYDPLSSVNVGPQPEVDPELLPEKFRHQWAVIDQAINDEFHSEDMKLSPLEMPKIEKPRIILNTAELKELDSIRSAFTCMDEPLTDFKAASYLQKAVHDPSDIMNIMDITIRRIVKTAKKLSRFQEISNDGKLVLLKSSMIDMLTIRGVVLLDEKMKNFSTPVLGKETKVSMDMFDKLTDPMQKQRFMTFCSAIHPVIRKNQMAVMLVALVVLFDDTRASKLAESDRTIVRHYHEMYYHLLQRYIESVYGDYAPDMIKTVPIALQSLAKTSATSINLFLGRVNTKDVAQLPTEFFKIESGINNVLGVCAPSTSSSSTATITRQHTNTETSSTTVSNSGTDYNSSKNDDENEMGSVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0Z4</accession>
    <name>A0A914Y0Z4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0Z4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11511.t1">
        <property type="protein sequence ID" value="PSU_v2.g11511.t1"/>
        <property type="gene ID" value="PSU_v2.g11511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11511.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21506" checksum="0100B92DD1E0371F" modified="2023-02-22" version="1">MGISSFRASQYSILYPLTQLTIFSAFRLPIDNSTMPSRKSFILGGYGICLVIFFCFLLSIQGIEEDKTKLIHNSGISAALFLVFAVLQAIPCNTSFCFITERYPDRESRVKALVKSRMLLWGLSTLESATFLPILKATNLFIALIPYFVISVALFVFLLMLLGSMPEEEENDEYGEMTETVQLKNYSTCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y173</accession>
    <name>A0A914Y173_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="3 8">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="3 8"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y173"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12973.t1">
        <property type="protein sequence ID" value="PSU_v2.g12973.t1"/>
        <property type="gene ID" value="PSU_v2.g12973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF64">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="10">
        <location>
            <begin position="205"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12973.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="33562" checksum="9571E15512241F02" modified="2023-02-22" version="1">MNDEAELMESNLLTHLDSLCLPSHRRMLVFGGGKMALAIVEGIVKAGLLFKENIFISTRTEASGKIWKDLQYRNVFTNNAHLCEACWSPDPKFWIVLIAVKPQTRFTLFDQLRDDMSFDRITRSFADGQMLVISVLAGVDTPTIRQEYTQHLFYNGPILRVTPNVACAIGSGTSLVCSDPLTPRKFVDIGIELFQAVGVVKEVPEGLFDAASAVAGSGPAFIFLIIEALTDGGVAAGLPRELAIDLASSMVKGSADLVIATGREPAKLRGDVCSPAGTTICGIRELEKGNVRSSFIEAILSTAARSKQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1K8</accession>
    <name>A0A914Y1K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1K8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13111.t1">
        <property type="protein sequence ID" value="PSU_v2.g13111.t1"/>
        <property type="gene ID" value="PSU_v2.g13111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13111.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23816" checksum="6D831A75876B3A61" modified="2023-02-22" version="1">MSKLDEPRNSIFDAAETAGLMTLNPSDLVFEANQRGIAYYDFVLSSAKLPDGSFQLFLAKFDSKTNLEWLETATASEGIIKKNNLPDNDLAMMTLGILTWRQRLARSKILCLVNELGTESSVELEALKRAANKFKCMHHVLTIGMKRRNSSVNNNSSTIRRHSSSSQDGMRLRIMMCQTRAEIELPAQAVRETRYLLVPNSNPLLCLCFPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2I4</accession>
    <name>A0A914Y2I4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinoblastoma-associated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2I4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1366.t1">
        <property type="protein sequence ID" value="PSU_v2.g1366.t1"/>
        <property type="gene ID" value="PSU_v2.g1366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002720">
        <property type="entry name" value="RB_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024599">
        <property type="entry name" value="RB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF17">
        <property type="entry name" value="RE32990P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11934">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01858">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01367">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein N-terminal" evidence="2">
        <location>
            <begin position="138"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Retinoblastoma-associated protein A-box" evidence="3">
        <location>
            <begin position="448"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1366.t1"/>
        </source>
    </evidence>
    <sequence length="696" mass="79730" checksum="69A51098FC5F9D3F" modified="2023-02-22" version="1">MRTRSKRQAATTTTAAAALPPPDVNKDEDENDAEENEVADEEEEILSTPEEENESKEESALDNLDPVVPCKDSEGSNTTAHNDLAAIFDAFGIEKTHEVFDKTLRQFDVVKQQCIMEALKEPQKTWLACCLYTTAWSTSAVTMKPAVQFSVIGLVDICELSVMEFFDKLERWAILMNASSRMVDHIERVQGNLSVSIVVFTKFLPIFRQIFVPNQEATLEDPDDSATNTAITTFKIYDYIWVTYCAFKKQLQKGNEDLMNSVHLLLIVTDLILGDIIAHDLMQFINKSFLVELSKSGKTVLDFYCDLYNGVPLDAKHFRSHWFYAQAKTFYEAEYLKFNAETYTEFLDNIDYNSGYLNTVYEEAIYERLEIDERIFVTRIQPENLFDETVDFGIVTNIRPIPDGTFSRNRDLLSRKASEHSLSKVNTSRCMKTPLSGRAYLATSDMVNPVTENLEMSRHQRLMLLVENHDEHMNEIYADIMNKKFDGEVAAAVDAILNKLNDVLILKVNTEKENDPNFDVAFTHDIQTHVQTIYQLLVRFLQRITLTEHQRLMNVATTIECLAGVFQRPEFITSLYICCLELVIFSYSSKREFPWSLEMAEIAPITFYKVIEPVIRCDGDLSRDILKHLSKIEERVLEELAWDRASPLWKTLADGTKIPSYEEVMIPDKNGEPLTPRSMAPLQSNVLTRYAKIGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3L0</accession>
    <name>A0A914Y3L0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3L0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12350.t1">
        <property type="protein sequence ID" value="PSU_v2.g12350.t1"/>
        <property type="gene ID" value="PSU_v2.g12350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12350.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9276" checksum="A2512F1C04341BF0" modified="2023-02-22" version="1">MKKRKNKRKKNKNKANGGYDGTSADDSRISEKDEEVEVNRSNGNEPKDKTHKKKAKIQQHEQMEADEVELNGILSSDIYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3T4</accession>
    <name>A0A914Y3T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3T4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14856.t1">
        <property type="protein sequence ID" value="PSU_v2.g14856.t1"/>
        <property type="gene ID" value="PSU_v2.g14856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14856.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11076" checksum="76A5F8D67DE71E5F" modified="2023-02-22" version="1">MIHRALLSVNRFAITRRAGASGIQMVRQVHKGHESVPPMRWMPISERMGLFFFIAFTFLSYPTYVLMNLDNLRPKGENSLGEEALEERERRIAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3V9</accession>
    <name>A0A914Y3V9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SecA Wing/Scaffold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3V9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14119.t1">
        <property type="protein sequence ID" value="PSU_v2.g14119.t1"/>
        <property type="gene ID" value="PSU_v2.g14119"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Helical scaffold and wing domains of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33747:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE-ASSOCIATED CAP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33747">
        <property type="entry name" value="UPF0225 PROTEIN SCO1677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="Helical scaffold and wing domains of SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SecA Wing/Scaffold" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14119.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13765" checksum="F2A3BD93ABDDF632" modified="2023-02-22" version="1">MDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEELEQQRRMEAERLAQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCPCGSGKKYKQCHGRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4G0</accession>
    <name>A0A914Y4G0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4G0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14327.t1">
        <property type="protein sequence ID" value="PSU_v2.g14327.t1"/>
        <property type="gene ID" value="PSU_v2.g14327"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14327.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16748" checksum="B16DC1AB37F0DE3F" modified="2023-02-22" version="1">MVNENDVKLADFGLCCKCNETETYYAISHKKLPLKWLSPEALTEKKFSEKSDVWAFGILCYEMFSCGKEPYFTFSTDEMLEFLQSGKRLMVPKDTPEPISLIMADCWNENPADRPTFAILEQRIKGILEVETLKYGYVTIIESFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y593</accession>
    <name>A0A914Y593_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone deacetylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y593"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14606.t1">
        <property type="protein sequence ID" value="PSU_v2.g14606.t1"/>
        <property type="gene ID" value="PSU_v2.g14606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF45">
        <property type="entry name" value="HISTONE DEACETYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14606.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24710" checksum="0E86AB55A698D168" modified="2023-02-22" version="1">MGLKKVLIIDFDVHAGQGTQYCIEDDPGIFLVSMHRYESGHFWPNLPESNIENKYKQTLNVPLQRTGLGDAEYATFIDLLVRPIITDFDPDLILVSCGYDAAFGDREGEMKVTPAGYGHIIGSLASLKIPLVVLLEGGYFLDAIPEDAFYTVKALIDQKPTSLPLGFPLLGTVDEIFMKNLLTIMDKIKKRFPTFGILLEQFVKFTGNTVPHQVYCSFIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y711</accession>
    <name>A0A914Y711_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y711"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14531.t1">
        <property type="protein sequence ID" value="PSU_v2.g14531.t1"/>
        <property type="gene ID" value="PSU_v2.g14531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14531.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14945" checksum="C28AE9CE66D66E2A" modified="2023-02-22" version="1">MPQGGSTSKEEANLGKIEVGELKSLHLKDVQEFHAKRTTLFNMSKHTPADRAAAPEPEEDNEAVLQEYVSTYAADPATIRPCFSYSLVSALGWTGFFSHCHKIADDTAATDKMKCKKCNAVYQYLLTIKRGLSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7P4</accession>
    <name>A0A914Y7P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl peptidase 9</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7P4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15296.t1">
        <property type="protein sequence ID" value="PSU_v2.g15296.t1"/>
        <property type="gene ID" value="PSU_v2.g15296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="623"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15296.t1"/>
        </source>
    </evidence>
    <sequence length="821" mass="92356" checksum="846E47D8FA56648F" modified="2023-02-22" version="1">MAPNSVLSYDVLLNDMSWNDCLRHSRYFRLAVKKSFGDTMNNMQIVKLRDGGGPVLFGVGGCEPQTVISAQIPETLEPSVAIHAPIPEVSLKPLFSMNHQQEENNVQPSAEVQLFYERMRSNVVSGITGFTWHIETGALLLSSYNKVQILRKGEIQPVAEWFSGAIMNATLCPCDAEFVAFCANGQLFIDCKNSQFYSTKVTPNHTSGIASFIAQEELERFEGFWWNPKTTEILYEEVDETDVAELSFEIPGKRVGDPMRYPLAGTQNPLSSLKLITLDKQTASVNERKLGASLEELFPWYEYLVRAGWADSEHIYVLLMNRKQTQEALILIHKGAFQAHGKSVEEIRTEFVFVIYAETSSVWLNSNNLLHFLPSIGSELHFLYGSEKKDFCHLYYRSCKLTNTCDNLGLNITDLYETPITGGSWSVMKEAPLSVDRSRRHIYFLSNQISSLITSLCVSSYSVVSGSKILTPVDLCYRVERGQFSLNINPDIGFVAWVSSTKQLPECRFYRLMHSGHPAPNSPLPEAIYHCRLSVQPTIISNPTKDSLDEADYLRAALTDCFEAKFIEYQSRESGFIHHAVAFIPTVKSNSVNGLYPCIHHVYAGPSVQLVKENWQFVAQFLKFLTLGYVVVVVDGRGSANRGISFEAPIKNALGTVEIHDQVEGLLECINRCKVIDRTRVAVTGWSYGGYTSLLLLCNYPNIYRASIAGGAVTEWALYDSCYTERYMDLPKDNPIGYKASSITKFAHKFPNEEGRLLIVHGSIDENVHFTHTEQFMNALIAAGKPFEQLIFPSERHGIRQGSAVEYFHAKMLTFFQKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7Q8</accession>
    <name>A0A914Y7Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7Q8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14783.t1">
        <property type="protein sequence ID" value="PSU_v2.g14783.t1"/>
        <property type="gene ID" value="PSU_v2.g14783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14783.t1"/>
        </source>
    </evidence>
    <sequence length="477" mass="55430" checksum="AA6A7F5C7F105E43" modified="2023-02-22" version="1">MADYFFDDLIDIKEDIIIIQQEYDGMIQQFPPPWTEFQKADFHVLRTALMRNRDKWDEEFNLIKVKIDRLQNNDPAKNLTRQRLRTFKRNDENKRIQREMSMQIDRIERYLLLEQRFEQPYTDQMSSRSSIAFSEEETQLDDESVSNAVVLPQAPIVVNNYSTSPGKHTLASVSSSLIEKPIVLTSDIPIPSRPSTFHQIQVPSLNIPKFTGEYLKWNAFWQTFEIAVHQQNYPQVSKLIALRSYLGGRALEEVESFTISGENYETMVNTLKSRFGNPQFIIREFDLKLNALRPAQSNAESIRLIVVSVTNICREMKNFGINTDNYSLKNQIVSKLPPKEKCTLELMLFKNPETSIDIILEKMKEMEIEAEFFSSSKSRQQMPSSTRPLIDESVQAPVWQPTSSTNQQHQRPCSFCDGSHRSFKCMKYKTTEERINCLKAKKCCINCAAADHLQSECPKTSLKLTMCSKIFYFRQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7T2</accession>
    <name>A0A914Y7T2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7T2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14807.t1">
        <property type="protein sequence ID" value="PSU_v2.g14807.t1"/>
        <property type="gene ID" value="PSU_v2.g14807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052448">
        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14807.t1"/>
        </source>
    </evidence>
    <sequence length="507" mass="59330" checksum="A4BCBD82C2A574F1" modified="2023-02-22" version="1">MTDGVLLEKLRVTTLPSIVVLVEGRVVHFRKSFNGINAKSIRLFARDVIPTTFLHRITTHVMLRRFLDQWKTTNRISVLMLGTKEEPRLRYYLTAMKYSHFARFAYVFLGSHQEDIQSLKTALNIKCRDCENVIIFKEEPEKGEAARITVSTNQFSQDELQGVIEKNKFLQLPRLSSMQYFDELCPTSSRSLRHYCIILPVTDAESEEPFVSALYRFINAHPRSDKSRVKISYIFSNRQDFFLQHFSAPKISDDTKRKSILVLWRNEYVKAKYAWLEGIWNGDELEEYKTFDLLKEKLHLIERGNLRLEETAKIVNLLDEHIPSWFTRLSRRVIRMVETVWFYIAKEEALPVLSVIGSFFVIMLCGYILNAAFNPDKKQRVFEKQPSSSDWHPDDPRTPPTRNESMRSTASSRQTRILKEMEPMIHELRAETYFGLIRLLKPGCRSIIVLVDKESKEVLLHQFARHVYPLRNNKTFSFGYLMIDKNLAWFKTLLEQILPGEDGEGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7W6</accession>
    <name>A0A914Y7W6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7W6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13694.t1">
        <property type="protein sequence ID" value="PSU_v2.g13694.t1"/>
        <property type="gene ID" value="PSU_v2.g13694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13694.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="7651" checksum="864727B43143E317" modified="2023-02-22" version="1">MMLFVKLKSGHALSVDCEENDTVETLLREISAEKSDDDIAVSHKGNVLDRSRKLSDYEIYEGAVLHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8K1</accession>
    <name>A0A914Y8K1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8K1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15081.t1">
        <property type="protein sequence ID" value="PSU_v2.g15081.t1"/>
        <property type="gene ID" value="PSU_v2.g15081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15081.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23715" checksum="572E43177B7FDF9F" modified="2023-02-22" version="1">MLREMLNVLKIRAGGDFSMTKWTGGARNITANNIDQIIHTREEANYLCACIHYMASEMVSKSMFGVYYQDMTLSGILFTEENSLVIPSINFAPKFDAKKAFVNIVPRFDSIYDAKTIAVYLRHFIHVMERQASGDFSNNFYNTAGGLWNTAVRHALSSFLDSAITTREEANLMVALARLYALRVIETYPPHFSIFFRDMTMSYRRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8X0</accession>
    <name>A0A914Y8X0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transporter transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y8X0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16636.t1">
        <property type="protein sequence ID" value="PSU_v2.g16636.t1"/>
        <property type="gene ID" value="PSU_v2.g16636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1710.10">
        <property type="entry name" value="abc type-2 transporter like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051449">
        <property type="entry name" value="ABC-2_transporter_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30294">
        <property type="entry name" value="MEMBRANE COMPONENT OF ABC TRANSPORTER YHHJ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30294:SF44">
        <property type="entry name" value="MULTIDRUG ABC TRANSPORTER PERMEASE YBHR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="155"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16636.t1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45292" checksum="E16C6B93CF41F898" modified="2023-02-22" version="1">MTGSPYIDATISDNPDPLLLSRDAGDVAVYAGVSVYSRRAVSRVAADSVFYLQPVFTQYPGDGAADFHDNPQPVQCRSGRSERGFSAVDYAFRLYFSDRQYARGDPRGDVHYSRSLFRQHPAKPVPRREYSSGAGGKRAVFDRFGGDVYRPDVILFPFAATLEVTNATIAIYDEDNGEHSVELTQRFARASAFTHVLLLKSPQEIRPTIDTQKALLLVRFPADFSRKLDTFQTAPLQLILDGRNSNSAQIAANYLQQIVKNYQQELLEGKPKPNNSELVVRNWYNPNLDYKWFVVPSLIAMITTIGVMIVTSLSVAREREQGHHCAGDWYLGVSNPLRRIAGAVLLYDGDLRFIAGGIRSVDFITLLDTTAGVYRRVCLYDARHSPFRLRFAGGKHASLAAKPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9A8</accession>
    <name>A0A914Y9A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9A8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16782.t1">
        <property type="protein sequence ID" value="PSU_v2.g16782.t1"/>
        <property type="gene ID" value="PSU_v2.g16782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16782.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="20077" checksum="C9938FF2958CAC28" modified="2023-02-22" version="1">MEKGTGSNLVVVSSGSTLREALATSPICRAEGGTGAPLVNVNAGGFDFEGEEDPELALALRVSLEEQRARQRQEEANANPTEGSGAAVMEVDKPASTDAAASATSTASVAQPLSVDPGAMTEEQQLELALRMSLQDAAPAPSTNKDEPSASTMEVDEPAPGTSGLDNLITDPSALQDMMDDNADSKKSDNKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA39</accession>
    <name>A0A914YA39_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YA39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16151.t1">
        <property type="protein sequence ID" value="PSU_v2.g16151.t1"/>
        <property type="gene ID" value="PSU_v2.g16151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="9"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16151.t1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28308" checksum="108D6502F93FD0AD" modified="2023-02-22" version="1">MAIAGDFGKVFTIGSVFRAEDSNTHRHMTEFIGLDLEMAFNFHYHEVVETIGNLLIGIFKHLQENYKDEIETVRKQYPSEPFIFNEKPLILHFSEGIKLLRDAGIEQGDEDDLSTSNEKMLGKIVREKYQTDFYVLDKFPLAVRPFYTMPDPTDERYSNSYDMFMRGEEILSGAQRIHDPVKLIERAKHHQVELDKIQSYIDAFKYGCPPHAGGGIGLERVTMLFLGTGNIRLSSLFPRDPKRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA42</accession>
    <name>A0A914YA42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14387.t1">
        <property type="protein sequence ID" value="PSU_v2.g14387.t1"/>
        <property type="gene ID" value="PSU_v2.g14387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF106">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14387.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15805" checksum="4989E8326200B6E8" modified="2023-02-22" version="1">MHSPSLGMTENVHKKFFTISDTPFKERCATLIFYESDPFIHEITMAHDPKCHPPWSDTMPSKLSDFICAKSLNPRSPTSLRTCHGDSGAGLEQRDSYNVSTLIGITSFGSKGCPANELARFTRVSKYLNSICEFTGVCYTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB18</accession>
    <name>A0A914YB18_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YB18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14689.t1">
        <property type="protein sequence ID" value="PSU_v2.g14689.t1"/>
        <property type="gene ID" value="PSU_v2.g14689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="13">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="15">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="14">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14689.t1"/>
        </source>
    </evidence>
    <sequence length="729" mass="80212" checksum="AA45E956A5991E38" modified="2023-02-22" version="1">MLSNSSKLGTRLWSLQNRAAATSIRQQSTAPKKVEVFVDDKKVLCDPGMTILQACALVGVDIPRFCYHDRLSIAGNCRMCLVEVEKSIKPVASCAMPVMNGMRVKTNSDFSKKAREGVMEFLLVNHPLDCPICDQGGECDLQDQSMAFGSDRSRHQVQYDGKRAVEDKNIGPLVKTIMTRCIQCTRCVRFANEVAGVPDFGTTGRGGDMQIGTYVEKLFATELSGNVIDLCPVGALTNKPYSFQARPWELRKTESVDVLDALGSNIVIASRGGEIYRITPKMHDDINEEWISDKARFVTDGLRRQRLLIPLVKHEGNLEQSTWEEALFTVAKKLRQTSGNGVAVIAGGLNDAETLIAAKDLANRYNSENVFTEEDYPTASGGADLRSNYLLNDSIAAIEEADALLLIGTNPRYEAPVLNARIRKAFIHSDIEVGVIGSDVDLTYDYEYLGSSASAIDELAAGKGAFGDRLKNAKRPMIIVGVDALKGHDGNAVLGKIQKLADKLRGQSGDRKVLNILQRNAGQVAALDLGYKPMSEFEKNKKNIKFVYLIGADEHNLKRSDFAEDVFIVYQGHHGDNGAEIADVVLPGAAYTEKQGTWVNTEGRAQKGYNAVAPQGEGRTDWRIIRALSEVAGRTLPYDNLQEIRSRLIEISPHFGHYGSVESSSFLKQALELAETKAPSKSLEVKQKELADYWMTNSISRASPTMAECVKAARRYVKDPHTEPLRLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB65</accession>
    <name>A0A914YB65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17452.t1">
        <property type="protein sequence ID" value="PSU_v2.g17452.t1"/>
        <property type="gene ID" value="PSU_v2.g17452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17452.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8762" checksum="7E08664DD2403520" modified="2023-02-22" version="1">MDVSLYTLKQDVIEHFMLQNVNNVPVFYLDGDSIIEKLDGIGGDLLGEREVGDISYPHQHDDNFPLSEFFKMMKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBG8</accession>
    <name>A0A914YBG8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBG8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16621.t1">
        <property type="protein sequence ID" value="PSU_v2.g16621.t1"/>
        <property type="gene ID" value="PSU_v2.g16621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16621.t1"/>
        </source>
    </evidence>
    <sequence length="380" mass="41644" checksum="19CB0A8BD6BC8A4E" modified="2023-02-22" version="1">MIKCPLHGYGGDLEWESDQEGLVLAAQNAGSLLMIITGLYADKVNGKIMVSISLVLCTIGNLTLPWLAEKSFWYAIGARISIGIADACMTPSVNSLITRWFPQSERAAAIGIITGGRQIGTLFILPTAGYLCTRKDINGGWPTIFTLSGIISALVVLFWIPMGADKPSKQYCISHRERLFIESKIACESIGKRTQKRNVPWKHLLTSLPLWVGIFSLICHEYPLAFNAVASLGLSFSIFAVPFFGKEHAGFAIVSLCFAMAFAGLHTPGVQTALLQLAPPFSGIITGISFFIVAWFSICNKILTKWIVQNGTREEWGVVFFVSSGVAFLPVIVFSLWGSNERQWWAAPSSRTSFYTLSRQQSRSSFGSSFTAKSTKSLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDH9</accession>
    <name>A0A914YDH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxine 5'-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDH9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17486.t1">
        <property type="protein sequence ID" value="PSU_v2.g17486.t1"/>
        <property type="gene ID" value="PSU_v2.g17486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000042">
        <property type="entry name" value="Pyridoxine 5'-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003623">
        <property type="entry name" value="PRK05265.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003624">
        <property type="entry name" value="PRK05265.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003625">
        <property type="entry name" value="PRK05265.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003626">
        <property type="entry name" value="PRK05265.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003627">
        <property type="entry name" value="PRK05265.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PYRIDOXINE 5'-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456:SF0">
        <property type="entry name" value="PYRIDOXINE 5'-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="Pyridoxine 5'-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17486.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27015" checksum="FF47719BEECE610F" modified="2023-02-22" version="1">MMRIVMAELLLGVNIDHIATLRNARGTAYPDPVQAAFIAEQAGADGITVHLREDRRHITDRDVRILRQTLDTRMNLEMAVTEEMLAIAVETKPHFCCLVPEKRQEVTTEGGLDVAGQRDKMRDACKRLADAGIQVSLFIDADEEQIKAAAEVGAPFIEIHTGCYADAKTDAEQAQELARIAKAATFAASLGLKVNAGHGLTYHNVKAIAAIPEMHELNIGHAIIGRAVMTGLKDAVAEMKRLMLEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDY8</accession>
    <name>A0A914YDY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein disulfide-isomerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17514.t1">
        <property type="protein sequence ID" value="PSU_v2.g17514.t1"/>
        <property type="gene ID" value="PSU_v2.g17514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17514.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13353" checksum="2AE764B3CF5E7A0E" modified="2023-02-22" version="1">MYLFLGLLIVNTFAFNSSEHDVIELTAKSFKKQVLESEHNWIIQFYSPWCKHCVNFIPEYKNAAKALKGVPTIMIFGNDKKKPLEFNGARTSEALVIAALEKDSSQIEKKHFSPIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YED5</accession>
    <name>A0A914YED5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YED5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15762.t1">
        <property type="protein sequence ID" value="PSU_v2.g15762.t1"/>
        <property type="gene ID" value="PSU_v2.g15762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF27">
        <property type="entry name" value="PROTEIN CBG26503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15762.t1"/>
        </source>
    </evidence>
    <sequence length="530" mass="60808" checksum="AC28F8F542BF8E0E" modified="2023-02-22" version="1">MKGIDKSANTILELLEKLVKKLYSDDGCKYWEIFMMNLGNLMTDQASTNTKLAKELPKLKELIAANDENWDQLTIEQQQKLIKVRSFACQLHILQNMTPVVIKSLLDHEKHHRNDNELKQPLIFILLQEIARFLGNRAASKYDVAKSWKSFCENHNIKFANVPDFKGHRFNILFAIAAAVFYLLDDIIKFYDEHKTQMHDAKIDIGAALKDPLVLCQLHLLAVLNAYVTGPMTRLTENSPTISSLTEHAKSLIEFLKRVDEEPMELLHGYAPFEDYEEAEEVTARSKAHIENLDYVSPVDPEIICDAIQYVCEDLLEYCQKKFAAFLEGGEHFQTTSDLRSVPRSNRRCESIFGFLGSDYSVAPQKRIARRDIKIQTKVNKTFDWYKAKPQEERERILKEAMAAASKLRADAAEEETILGKAIWKKLLEKKQNDDKLTLIKSRKAQEAFNKVQQNGGIWRDAEQMDNVLNSLTATKKRKAVEDQLRCHKLYLQTLEATSPLFKFSAKKVTKDIGTLMRNLTSLMAIAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEY5</accession>
    <name>A0A914YEY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEY5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15946.t1">
        <property type="protein sequence ID" value="PSU_v2.g15946.t1"/>
        <property type="gene ID" value="PSU_v2.g15946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15946.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22946" checksum="87AC8C0FB8F71C36" modified="2023-02-22" version="1">MDLVFLIDVSETMTEERLNIVKSQLISAITQNGIKWESTDNNTARVGIILSAGLFSTERAMPRRFLDFQGHQTDIYRSPKIVSRTHHLKQAFRDIIFDFGINDIGLSMNFSINGDSVGDFPFGDPIFGGEGDRPNVPNAMIVITGADTSNATVPSTLLKNSNVQVYAIGFQDVSIAQLQAISGDPTRAFSSSPENLANDITNICNGFLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF87</accession>
    <name>A0A914YF87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17982.t1">
        <property type="protein sequence ID" value="PSU_v2.g17982.t1"/>
        <property type="gene ID" value="PSU_v2.g17982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="1">
        <location>
            <begin position="117"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17982.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28246" checksum="D8BA559429C4B980" modified="2023-02-22" version="1">MVITEPAEIKHASVGDAVLAALALSSKGPIKEADLKPLLNRGRFKDWQDGLNDLNAAITHAFGTTLVHDGPSHLFFIRNDLYHIREELTELFLDGSLDGVRIDDGPATINPILDYEEFSEDDKKGLLFALLTSIMMSNNIEMGHKHWLVDDDILHKLCKQMKVSDDIIKKLLSGYNAEFIRSGWIRKVEEKDANQDVNIRYTWGPRAINTISSLTIFKKYCIINKQSELEFGNYLEILKKLDEKCGFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFF1</accession>
    <name>A0A914YFF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFF1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1818.t1">
        <property type="protein sequence ID" value="PSU_v2.g1818.t1"/>
        <property type="gene ID" value="PSU_v2.g1818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF9">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1818.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="38366" checksum="5AD631C405F1EE04" modified="2023-02-22" version="1">MQVLNNTNISKPVVVVVIEKESQLENYQLAHNTLACYCKIYGYRLIQFVMDKSPEMQKLCPQKHIWFQRICVPMKILQLNPDINYLFFFDADIGVINPNHRLEDYINPKYDLSFYERTFTYDIMSGAAIIKNTKYAIEFLQDWVKLEDTFKRDYGTNDQAAIHQVFLDRFYPNHPRKEKCEKIWAKGVVLADHTPYVACARSILNDTLEFDRIIIYPKGSHKAWVRDIWLTGSEWAPRDFLVHDLEQFKITNDPELISKEPWWYFPNPFLSDATFHSSRCTFPDGLNCWKYNSTFITSNETVDSKIMKKAAEVRQWYLDYLKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG17</accession>
    <name>A0A914YG17_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YG17"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17709.t1">
        <property type="protein sequence ID" value="PSU_v2.g17709.t1"/>
        <property type="gene ID" value="PSU_v2.g17709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF3">
        <property type="entry name" value="PROTEIN DISPATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17709.t1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40615" checksum="0CA6AB25D8AD0E52" modified="2023-02-22" version="1">MRKPLALNHPDRRLPPPPTSPIISHSERRKQLPHPSSFSPKAHQKFNHLPSSNSTFPLSPTDPSERRFPRSPVVTPKAHQKFNQIPPSKPIPLSPTDHSERRFPPPLSVTPKSRQRFNHWPPNPIQLSPTDTVYAQPYGHQHLHQHQQLQLQQQQQQQQQQQHQQQQIPSTSTPAATTSTSTSSSQRGEEIFQPVKVIGIANINEKRDFTLPQKRPSKIRWYSNLIFNYPATVLAVTLLLFCALPLTILQIFPLSLDQNPEKGFDTRGTEYSNARLTWTKLQPFLVQGSRVIIHQPPPPLEELKIIEPLKILEERQKMSKADNRSKRSFEDELAALSSVQKILCEYSGMGGEQGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG97</accession>
    <name>A0A914YG97_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YG97"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18339.t1">
        <property type="protein sequence ID" value="PSU_v2.g18339.t1"/>
        <property type="gene ID" value="PSU_v2.g18339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF6">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18339.t1"/>
        </source>
    </evidence>
    <sequence length="454" mass="49282" checksum="B29A97616825BA28" modified="2023-02-22" version="1">MATAEISPEASSSVSIGMLPPTDAMHFQGSPSTSSEENSNLMLTPKKIEPFIPRRSETISLSSATEPPKIGQKRSLSQAEFKNLPRFTANVPEGSSLPAPSARIPSSPSPKNDIIRISRPNSPSNAGRIVLPRSRIANIRRESDCSLETEVAHERYIKTAVQVSVGFEDFSLDDKSEDRKRAKSFTDPISITILGSSFPTSSNSPTRANVDQAKQCYSPATQQLVRPNISYSPSPSPTPSSPKRSRVMRSMSPIVTRQISKRRYTNNSGNCSGNSDTEGPPLSSKRQCTSFSKSCGSPLVREVPTFYNPNAPPSNCSDTSFNEPTVTQRTSSPTPSESSTTSSVTSFFKPRSYSDQLLNTSNQTNGDSDESSFVNDDQEVQYAQKDDQCSTTFSSRACTPVDEGDIRLPDEAPVQCTTPTGLIRTFTAGSSSPFRFTLPPSPLASQRLRDASDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGB8</accession>
    <name>A0A914YGB8_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g17818.t1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17818.t1"/>
        </source>
    </evidence>
    <sequence length="244" mass="25363" checksum="63AF007626B8B930" modified="2023-02-22" version="1">MESIPDRNRKKECPSCGSLVEGAAYNDGMMKGIANITKSSSSPCRQQISCSRLDASPDGLAQISVTIEASGSPQTVEYGDPTAELTLECGTAGKYIIVGNPDYPLTNTIQCESTPAAPTTTTTTTTTTAPSTTTTTTPAVPTTTTSPISTTTTPVLPNACPNCGSLVEGAAYSDGMVKGYANITKNSGPPCTQQIICSRLDASPDGFVQISITIESSGEPQALEYGDPTASLTLELSPFKYYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGI8</accession>
    <name>A0A914YGI8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ATP synthase regulatory component factor B</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="PSU_v2.g19418"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19418.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23122" checksum="67B0A502D3E857D7" modified="2023-02-22" version="1">MARFLIRASDSFKNKLASHEIPGLRWLIDGFNYRDMSRLKEIGPDRLAAEWVVKNNGAIKFDKLSTRFDDYNMLIRATAELDPRVPKEQVHLIEIDATDSSVSGFGCYHFEGLNDIKSVAFIRCKSLQDFGLEYMGRYAGNKISYLTLESCPRITEYGLEHLKQFSALESLILKDLKNVHRPKETIDSIRRSLPNCDIHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGW3</accession>
    <name>A0A914YGW3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriophage protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGW3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16555.t1">
        <property type="protein sequence ID" value="PSU_v2.g16555.t1"/>
        <property type="gene ID" value="PSU_v2.g16555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024459">
        <property type="entry name" value="Acb1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06381">
        <property type="entry name" value="Phage_portal_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-CBASS protein Acb1-like N-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16555.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12831" checksum="61CB02F0A240C8F1" modified="2023-02-22" version="1">MQTPNQHSASTYRANFTSRNRMLVEWSYRSSWIIGEAVDAIPDDMTRKGIRITSEIDAKDRGILESQLDELQIWDALNDVLKWSRLYGGAVGFIMIEGQAPMTPAATRTIGRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH81</accession>
    <name>A0A914YH81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NFX1-type zinc finger-containing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH81"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18683.t1">
        <property type="protein sequence ID" value="PSU_v2.g18683.t1"/>
        <property type="gene ID" value="PSU_v2.g18683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18683.t1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44829" checksum="4EFE8677A18210A0" modified="2023-02-22" version="1">MGLFVICNMEFLAKRSEMWKRIQESVEEVDALDGALTVKCEMHGKEQVITCGEDFDAKCREGGCDDPCNTRLNCGHMCPKPCHVEDMDHLVMKCLKPCAQTCPAEEKHPCKKRCYQACGDCKINVTKFLPCGHTKMDHCYLEAGEVLCVERCTETLQCFHRCDQLCGAPCTTKCQVIIKRQLPNCGHIVLMKCFDNPYTFKCHVIVPKQWTICGHTVDVPCYINVLTTTCPNPCNTALPGCEHLCQGTCGSCRNGRLHIRCEEKCKKVLICGHECESNCSNSCPPCQKLCQTACAHSQCGKKSLQKRSRRNRRKNGSKGNDKDPTSGRVCGDPCPPCAEKCLNKCWHRSCSKKCSDPCNVEPCNERCQKLLRCNPKRKSKNKKNAKANGTEGKVNKHFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHJ7</accession>
    <name>A0A914YHJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase F0 subunit 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHJ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1879.t2">
        <property type="protein sequence ID" value="PSU_v2.g1879.t2"/>
        <property type="gene ID" value="PSU_v2.g1879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010876">
        <property type="entry name" value="C1orf43"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07406">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1879.t2"/>
        </source>
    </evidence>
    <sequence length="150" mass="16939" checksum="4346A8B53D79E3AD" modified="2023-02-22" version="1">MIGFDEINRSVDRQLEFINPHIVRSPGQSTYAFLKELREMANLTELDENFIERLSFLHESCRFRTVVPFGDEHLEELRGILKEFLKILGNNQAHLSSISPLTGKAQNNDGGRRPSAGITLRRGIRSQKGTKMVEEIPLLHVGGIVDKGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIE4</accession>
    <name>A0A914YIE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18588.t1">
        <property type="protein sequence ID" value="PSU_v2.g18588.t1"/>
        <property type="gene ID" value="PSU_v2.g18588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18588.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19409" checksum="F21EAB9A41A5DAEE" modified="2023-02-22" version="1">MVKAKSRGNSVISYGGQNRRFSNHHRSHANTFARTPSSPLFGLNSTVTNLNGTTAVEVVRKENNTPNGDTTPIINNNNNTKRSSTSGAMKRTSFAIGNGQINYENENNNHPLRNRRKSFIPDDFVEPSYSVENGCSNRPPTDLANNIDACAAKAFPAFFAFFNIIYWWYYLHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIZ7</accession>
    <name>A0A914YIZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17286.t1">
        <property type="protein sequence ID" value="PSU_v2.g17286.t1"/>
        <property type="gene ID" value="PSU_v2.g17286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17286.t1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41361" checksum="A29A002FCF9A403B" modified="2023-02-22" version="1">MDEKRKIERISSKQDASNASAPSAPTWSSIAAPKKDTDNFKPVAATCESKPSENRESEAARQQEVANLNAVRKNTDIAGEKLPQIAKKDNTVSEKDDVSKNEEDEGNPKQEKYEGKNDKHQGTPKHDRYERSNNGNNSGPRNNFRKGRNRNNNEDTRNYTSRPSGNATLFDHIRTQMVNPPPESPIRQHDNTQGNRRNNGSRYDNREGYNNAHQSSSSTVASDEFAQMKVSDVPQDPPHGGNNYRNGGTRGRGGRGKPFYANYSNPYQQHAPYPQQQFPPIFAAPPHPSMLPPPAGYVPPMPQHIRNPNVTGIEIGKQVLAPFTDNNYYLGVVLLVDEVNGMSLVQYTHCPLPHFIHTEYLQLCHVQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK90</accession>
    <name>A0A914YK90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19753.t1">
        <property type="protein sequence ID" value="PSU_v2.g19753.t1"/>
        <property type="gene ID" value="PSU_v2.g19753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF354">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19753.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="21675" checksum="413DCD3BAB4BACBC" modified="2023-02-22" version="1">MFKRNHKGDCNCDAEPGPPGLPGRSGIKGAPGVPGTQGKPAILPCQPPPDYAKWCPEPCPGGPQGPPGNRGPLGDKGIKGEAGKDGTVGENGKRGPAGPRGKPGTPGFDGEDGAPGIDQEPKPFIPGPAGPQGDPGPQGPPGPRGMPGIEGPQGPMGMKGQGGRHGVPGQRGLPGLQGVSGDPGKEGEKGVCPTYCANDGGVFFVEPPEWFFNEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKL4</accession>
    <name>A0A914YKL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17859.t1">
        <property type="protein sequence ID" value="PSU_v2.g17859.t1"/>
        <property type="gene ID" value="PSU_v2.g17859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17859.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7614" checksum="E1DB6AE7F21B118F" modified="2023-02-22" version="1">MEKGQDILNNVTGNTNPTQPSHQHTTNCAKGKCDVDHENHAGKTEVGSSSGESCCQTKQFNEGSHISTTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLL5</accession>
    <name>A0A914YLL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLL5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19798.t1">
        <property type="protein sequence ID" value="PSU_v2.g19798.t1"/>
        <property type="gene ID" value="PSU_v2.g19798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03714">
        <property type="entry name" value="RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="376"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1215"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19798.t1"/>
        </source>
    </evidence>
    <sequence length="1242" mass="138046" checksum="A2CAAC5E247B1F18" modified="2023-02-22" version="1">MALSTSSSDSESGIEEAIGRGSSQKDNSVRVSRSLSRTPTSSVDGEVHGPGVAAPAAPPDLEDSVSKVRVEMTAADLDKFRGFAKGSAPNGRDRDSWMDALPIVNDVASLSPRLDKTLRGNDMKISLTERQTIGIHDGLFAALNLMTLSNSQNIRGTEEEVKYRDRAQRVISLLIQDVTVLRREAALTSIGVPHAVVPGIRKRTLDLAPEKHPSVDNEFVHNLFSIDMMNDINKAIKKKEKDSKDTRWVVCNPGSLLATVTPDSISATPMVKEGKTPLSKAVTQLTQDKEITQKDNAKNLMLPKFAQIQAPLTAGRLKFFISNWKLITQDRWVLKTIKGYSLPFKSLRGQLSSRFRTPKITSEVIEKEAKELLAKKAIFKIREKKARWISPIFLVPKKDGSQRPVINLKGLNKKVIVKHFKMENLLMVKDLITKGAFMAKMDMKDAYFGVPIKREYRKYLCFQVNGQMYAFRALPFGLATAPRVYTKVIRPIAAYLRKLGINLIVYLDDWLFLADTAEKLEIDLKLASKVLTALGLVINKEKSILVPQQKIEFLGLEIDSTTLSFSVPVAKQVKIKAQAKALIDNPIKKARTVAQFCGLLASIKLASNYSSLKARFLQKMLKGVSYKAKGFDAVLDLSSEAIDEARFWSAATLEVFSRRILPPPISMVVRTDASSLGWGCAFIGQKSGGRWNLEEAKLHINILELRAALFGLQLACKGIKEVGVRLESDNISAIAYINKRGGTKSRELLCAAQELWEWALENRIYVIASHIPGIKNVDADTASRKFSENCEWELNQVVVSRLFDKWGEANIDLFASRANKKCENYYSFQAEPGALGTDAFAFSWKGIKAYAFPPFSLVGRTLQKALIEGVSLILVTPAWTSLPSWPKLISVAEGPILINGSNVFIALAGDEKKYLKHNFHLAAWYIYPSALRKWHIFCTNQEIDSKKPQPQDIINFLQEVSDSGIGQSAIGTHRAALTSLLSAAGNLEAIKAAEPFLSRFSKGLLRTKPTDPKRSDIWDVDEALIWIRKCWPLESLSPKTLTLRTVLLLALCSPKRANELAALSLEKLKQSQSVWEFRLIITKNRGFGIPHAARYLKFSEEESLCPIENLKYYLKFTEQFRESDKLLLSYQKPFGSVGSSTISRWLKCALVEAGIEGFTGHSTRSAATSAAAARGLSTAQIIGAANWSTRGRHEISIPSSSGKKRNYSASGSGGRHSRHSGHSGHRDHRKNDKKDSKRFRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMN1</accession>
    <name>A0A914YMN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YMN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21593.t1">
        <property type="protein sequence ID" value="PSU_v2.g21593.t1"/>
        <property type="gene ID" value="PSU_v2.g21593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21593.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18288" checksum="94686BC75E8AFD59" modified="2023-02-22" version="1">MKVKEFKQVKIKKFSGDIYVDVTFVLDKNGLLTVTAKSPTSSAEETIDYRKVRQAGKPIEQLFKELALNADSDQQKKILIEARTELRSNVENIKNRYQNEKNVPHNKKQSIIESCEEVIEWLDEHPDETLDEERINLAKKIEKDAKELIDLRLMTISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMV1</accession>
    <name>A0A914YMV1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMV1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20264.t1">
        <property type="protein sequence ID" value="PSU_v2.g20264.t1"/>
        <property type="gene ID" value="PSU_v2.g20264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF2">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037687170" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20264.t1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8882" checksum="4D08390FE5A35312" modified="2023-02-22" version="1">MNYIIFFGIAAIFGGCLAQNEISEFESPTDCGNKESEWKPCIERKIGDQVFSACCERFVPAECRGLCIYETHPIEARVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNU6</accession>
    <name>A0A914YNU6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNU6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20646.t1">
        <property type="protein sequence ID" value="PSU_v2.g20646.t1"/>
        <property type="gene ID" value="PSU_v2.g20646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513:SF27">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20646.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13894" checksum="02F84041FE891090" modified="2023-02-22" version="1">MSADRAFLLNVDPKNEVIFNGDPLKELTTILKITNKSESKQAYKVKCTRNDLFRIRPPSGILDFNASIEVQVSFKPTGDQPESDKHHIGIYHIPAPNGASASGAWAEHYGPPQGEKRLKICFENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP98</accession>
    <name>A0A914YP98_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-actin binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP98"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21251.t1">
        <property type="protein sequence ID" value="PSU_v2.g21251.t1"/>
        <property type="gene ID" value="PSU_v2.g21251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015015">
        <property type="entry name" value="F-actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08919">
        <property type="entry name" value="F_actin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-actin binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21251.t1"/>
        </source>
    </evidence>
    <sequence length="68" mass="8178" checksum="CA9E19E3EE22736E" modified="2023-02-22" version="1">MQRFHDICKIYAENISPHSKFRYRELLNRIESNVRQLRQCVATHTDSETKALTDAEQTLRHIMQVIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPQ7</accession>
    <name>A0A914YPQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">STML2-like C-terminal extension domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YPQ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2100.t1">
        <property type="protein sequence ID" value="PSU_v2.g2100.t1"/>
        <property type="gene ID" value="PSU_v2.g2100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STML2-like C-terminal extension" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2100.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="7859" checksum="20CC000AAAF14846" modified="2023-02-22" version="1">MEARCKALDQLSTTLEKGGAHSAASFITADNYVKAFGQLAKTNNTIIIPSNPADVTSMVTQAMAVYKQVSNRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQL8</accession>
    <name>A0A914YQL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g2315.t1">
        <property type="protein sequence ID" value="PSU_v2.g2315.t1"/>
        <property type="gene ID" value="PSU_v2.g2315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053295">
        <property type="entry name" value="Innate_immunity_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324:SF1">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47324">
        <property type="entry name" value="PROTEIN IRG-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038102236" evidence="3">
        <location>
            <begin position="18"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2315.t1"/>
        </source>
    </evidence>
    <sequence length="1580" mass="174913" checksum="1E4700E500AD38D1" modified="2023-02-22" version="1">MLFNFLLLALAVLGSNGNEWLDASSCKNGGTPTNTTDCICFEYFTGSDCGTIKCLNQGYLSNPSDLNADRCICPVGYFGLFCESYQQAPAQTDLFLVKTPDLIIFLNTRVQTLYNTFQFYKNAVLADPAISRGLNGNYSKYFLYEFDNEDPSRTKSLNFDNRNGFLTEFNRSDLTLRSTLTKCSPEPLFKTLLPWIKDNKFSQQTINIFTQLPSTTENFEELENLAIAFNLQFNIYFQYTDVLCHSDKTYDTLFPFELLAQRTGGFYWPFYQFDDSANMVTDLVRSTFNLQLLGYQAYADGNCPTSLSATFNHALGPVDIYTLVKSASSAVSINSSLSPPISTTAAATGTTFISLFPPFPQGTVTVTGATGACSIEILGIKRNPLEIEYLGIKAYLSFTDSIDADSSYFAMKSGVRQYIRLHLENIVSPLFGLTPLSAELSSDCKTNISTNSLSKSPSSTFDYISSASTNCLDQYGTCMSTKHWLTVTFSIQQVQNTFTVIRHIPIKCLSSNDNEVPTTEAPATTQPMTSVNPVTTVAAEITTSSAEQQTTTQDSTTETPTTEAPTTSEVITTEAATTVAQETTEAASTVPSTPFACPNDANLPAMIIGYSMQYDAPTVRAFLSSPLVFNSSTADPNYGHYVIFTTDSDSDIYDNNHANRETFSDFQTLVTSYSAAYQQGDPNRPTNVISILKQLLSDPLIKDRSAIFLLIGKTEVVGDENDKIEIMQLATSKQIRVNFYIDKALYQSTADPEIFKFYEQVSAISNGHFIIADVNKSTPGGFYVPQKIFSLLFFDSFPHKLAMSKTVSIKGADDLGTLDLSGQTGDRDFFITAAYSPYTNDVNSVYLMVIFTNKNGGQSPGPFSFVCQPETCENNPTPPPWATCSYGNVGCGAMLSIPAGVEYDITIINTIYNENSTLTYRLWEHWQDNEEYKIKNEYMDVRSQYQSSLSGPIYEIAAVPKVALSQFAVEKIDKLEVEFYDCDGKYVYTYDHYNYASVISNDSICGTTFMVNPFICNFEQTCSLERDILQGFYTTKYKIRTTDNTVLQYSTNFWCKKNEIPMSCPNADPTAVGLTSTVPSTDDVCQCLTRDAPHLRGPVCTVSDCSKNGYLQYDSSEEDFVCQCKDGYNGTYCEIGICSNTASRTAKDVNYRTFTIAIVHSNRDEFNNIVTELQNANFGNLNNIWQFNVFTVCNGNTKTRYFGTSKDTFTNILAGFKSNFDADLLSYCGSDQGINFTSVVKYGLNSFGKEVRGVFWIATHNSDIVEVDSLMDFYHVVQGYRQEIFLTAVLNVGGTTDLSSFNTTLEAVRVTGGERIDFGSYAGSTYAKYIENIVLSKTSLNYYDLITDSITNVEIPIEESAYLTISNGGYTDGVTVTPNCVAQPTVGKAFVYLCSTPGPVTVTANIQDGASLVTVRVLNGYTPAWVFINETNQDNLEAMPVLNTYPSIAFDFEDNNVIPHDTTPYSIARQAERVNCAFKYTSTFQLPVTSTGYDNFEITIEGQDYKKIIPYVITETLENRCKNGNVTIGDAKCTCPEKWSGADCSRPICEYGSLNIMQNACYCDLTHGGQTCSAPQLMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQR6</accession>
    <name>A0A914YQR6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQR6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19713.t1">
        <property type="protein sequence ID" value="PSU_v2.g19713.t1"/>
        <property type="gene ID" value="PSU_v2.g19713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19713.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19541" checksum="C90336576F978D3E" modified="2023-02-22" version="1">MTDQEQSHTGRPLQLCACDVSERGQGSEEASRVVFILSREALVSIEPDPSPKPTGPGPAALAASGKTEACFSYPDRRHRGRGKAGELCARPRPPFADHQQYGAEREAEPDCESVLGGDRRVPARHADFNLLQHELCLYADSAMGARRDSGDYFHRLVLHVAADLCETPGLAALERAAFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRA0</accession>
    <name>A0A914YRA0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRA0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g218.t1">
        <property type="protein sequence ID" value="PSU_v2.g218.t1"/>
        <property type="gene ID" value="PSU_v2.g218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g218.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24654" checksum="F3652EBA10F50476" modified="2023-02-22" version="1">MEPPEAKKARKDSSTSKNQVLKEKLEAQKALFQQFKNGEIDKVIEEIKAKKVFLKLKKSNIKVFFDDEIEKFWQYETFFTMLASEMLAEPSKCNEKSFEALHEVMKLLTAGCVSSSISARSTPTELFSSRNKNVSVPKLFTQILETGGDRMSTKTRVLLFDYISGLCTRKEGVIALSAFSAFVDQIAICIESSNKEIRAAALSTVILVSNKKNFLKTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRU1</accession>
    <name>A0A914YRU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRU1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20116.t1">
        <property type="protein sequence ID" value="PSU_v2.g20116.t1"/>
        <property type="gene ID" value="PSU_v2.g20116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR NPR-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20116.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24949" checksum="678023547DF4B941" modified="2023-02-22" version="1">MDLKEIDKRCSRGLKSNITKEAWENEPFSDKCLQNFFNEMNIHLRPFSEWESTLYTTIYAIISIFAIVGNGVVILAVIRKKDMRTNRNVLIVNLALSNLMLALTTIPFLWLPSMSFDFPYSNFFCKFANALPGSNIYCSTLTISVMAIDSFPLLVYYNTSMLYVFKDVWVYDEIKNVTSLKSYGWRQCRLEPSKNLDESEDNGGGGFNETRTIQVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS68</accession>
    <name>A0A914YS68_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914YS68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20240.t1">
        <property type="protein sequence ID" value="PSU_v2.g20240.t1"/>
        <property type="gene ID" value="PSU_v2.g20240"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g20241.t1">
        <property type="protein sequence ID" value="PSU_v2.g20241.t1"/>
        <property type="gene ID" value="PSU_v2.g20241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF452">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="41"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20240.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20241.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20138" checksum="DD5B908BD8D05890" modified="2023-02-22" version="1">MGDRYFPDQSNQEQVREQSKILDDFSNEHGLTFVEMDAHGKLRYCYQCSLIKPDRSHHCSSCGFCVVKFDHHCPWINKCVSYRNYKYFLLYLFYGTTFLVFELITSLEVLIRFGLSDNIMRDLDDFIPVAVSILIHIGFSYYPLGELLIYHARLVWDNETTCEQAKPPLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSM7</accession>
    <name>A0A914YSM7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YSM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3161.t1">
        <property type="protein sequence ID" value="PSU_v2.g3161.t1"/>
        <property type="gene ID" value="PSU_v2.g3161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF33">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="552"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3161.t1"/>
        </source>
    </evidence>
    <sequence length="1177" mass="136069" checksum="1162F76162C164F8" modified="2023-02-22" version="1">MGASSSTVSYDTLKNHRPNDLCELLCYSEGNIIYSVWGNRKTLNYDEFCTLFFPQQKVDDTLKKRLYGVFTDGKGTVDITQFSRNILFLRHGDRACLEKLLGDALPPEIDLSTIHWLKKDTIFDSFEEVITAVTHFSESDVIAINHFLTRSNRPEVLSFQEFGSMISIPCSDTVKEGLFKVFNVYNRPALAFTEYVSGISSITRGPETERLRTFCRIWDGKKKGYLDLNDIKQLYTDLNLSETERTLHQNFQEKVTYEEFVIWVLTNSSVNSMLLKLMFMIGCVCLGAPLEDNTSAATFINSFILDCEPNHFDEWIILNIGQYRSIIEALKDSKKFNGRSGEKIFSYLPLFKEFNHKLQHCFHKNLVLKKDFVAMPTFVFDTVCWWLKMDEHLGLPIRSSCHIKGLPTEWPDDWYRPKPTTNYFFDIYTPYAAFITLDHTKIVSGKYLQKLNRIIPIERLIPVYDVVQSLIEKDINQSHFRIRLLSVDDVPRDELITSKSTIAEYGCWRTVIFLIEERPEGWTQWPSHLQVGVSDIPTVNNNNKKYKAPGVTGLINMRRTCYLNCALQMIAGIKSMEVLRSEEFWNSMSTTLDNNISLTLELSRVYCSLVRNEVPFAPKEFKDIFLQKSGFQDNTENDCHEALESILNIVHDECHPYFQKEESDLLDKTGKTPQEQSDIAWAKYRNEGISFISNGFEGQMRSDLRCSSCCKVSYSFEPFKSFNLSLQDHDITVKVVIANLAQTVFVEKALHLSHDFKLDALFIRVANIIGVSSEKLFVLIPNAPANEQKNVMGNTEDHLLRNVIAMNDNDALIFYQLPNPFKELSNEICIVRQRLIRDCRTGLVDRIHRYSIMDAGAPFVFKYESGLTGQGLYKLVNDYFNLIKDECTLDKQFSMLNRALYESEKTEEYPFYLVYSDPTGLFCPSCHWTLYCIGCEIPATSDLIPYEKAKFISVQWKFMPYFLKWSGILHHSRIIDPSAQKLFYQNSSHRKISITECLSNAVSPETLETKLTCENCKTKCYFDKTIAFTRLPETLIINLKRFMCINGVFVKNKSSVKFPLKDFDMSPYMVDGTSETLYECVGYVIHRGEIHGGHYVCYTKRNNDWYFLNDEDVSKVDEKDIDQDDAYMIVFQRKKPGEILIEQELEDIEQEELPMDINSSFDHVVPTDDCDDDVHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSN7</accession>
    <name>A0A914YSN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Orphan nuclear receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3170.t1">
        <property type="protein sequence ID" value="PSU_v2.g3170.t1"/>
        <property type="gene ID" value="PSU_v2.g3170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052496">
        <property type="entry name" value="Orphan_Nuclear_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="97"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3170.t1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56676" checksum="73DE19D1C5ED5ED6" modified="2023-02-22" version="1">MIGIKIVLNFRLKRTKEYSCRYNGNCVVDRYERNSCRYCRFKRCLEVGMDPKAVRPDRDAAGRSHPIRHRRSRNSLGEIALEVEDETDDWIRKLPVDMRTLLMQIMNMDLLVAHGDTTEDAKKIYPLPYTSIRQILEEPHLLDGKRTEIRYETFRQIQADELHAIAHRRLIACIDTVEHLFSLMDLHNSQDKIAIIKNSYAPLSIFSFSAATAKMTKQRDILCLCNYGYVPRDIQNTIDDLFHLGNRVVDRAIDELVEPFRSFNFKDQEMALMNAIVVLNPHIKTLSTEAAEQIADLRDRVQETLYNVVRESHPKEVASSRFGNLLLFLPTIMMLGTIIYENLQFAQTFGKQQVDSLLGELLDNLEPVHDGNGLNVEEVLLMADNSDQFIRSQSSSSICSLNSHCSGSSFEQGYSSSASGSCNRIPSTANLHVSESDPDYNVTLTQQRYADIRQNIGSQPMDVDSCCGNSIMSGSDVVIRNPSNPSNNNNNNKLDINNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSP5</accession>
    <name>A0A914YSP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSP5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3032.t1">
        <property type="protein sequence ID" value="PSU_v2.g3032.t1"/>
        <property type="gene ID" value="PSU_v2.g3032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3032.t1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52737" checksum="07A29A8C44A26E60" modified="2023-02-22" version="1">MRYLQEIIRNHQTNMYLSSLNEMIDSLINYLRKSGTQYDNDSISDIREALQTIICWIDNQIINIYIPCEPCSSKNNYDSAIGLEKLSVLEKSLLQKRSEREISKVLVEEPDSSDERSSSCSDSGVDAENITPTRKGDPNYSFTSSNGSSLGGEDTLADLLQQLQLRKIERFEPQFPSVWPDSDEDDNDLHVDEESEEREEKHGSQTCEEEIERRPDGREIRMKKTRTVNVSQSHKSITIRTHGGGSNDIVKKFRDGSQSFNDDSNFESSDFFKKRPFANFKTDRPLGNNTSASSFSFDDEPSSPLSPDISTKTKTLQHSSATLQSVARHAKRDGKLISDNAAHKLDTSDLNAKQIDTYQGNTLLDRKGDGSYEESIIIRNGLPGIECTSNSAFAPIKKNVIEVTKTIGDNSLEGKDNFFQATTLASYISLNDNLRLFEEQHRRKVTYTFGTSGELYFCFFSIEKGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSV0</accession>
    <name>A0A914YSV0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSV0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2738.t1">
        <property type="protein sequence ID" value="PSU_v2.g2738.t1"/>
        <property type="gene ID" value="PSU_v2.g2738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2738.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8537" checksum="2C25A4D3FB968E8B" modified="2023-02-22" version="1">MLETIEDEEAMPLEPLNSFNFYPSNLQMPDIIRPEKRGTFQFYGARGKKSSAASSSGFNFGTMESKRFNYMPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTA6</accession>
    <name>A0A914YTA6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Achaete scute target 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTA6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3238.t1">
        <property type="protein sequence ID" value="PSU_v2.g3238.t1"/>
        <property type="gene ID" value="PSU_v2.g3238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="22"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="12">
        <location>
            <begin position="421"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3238.t1"/>
        </source>
    </evidence>
    <sequence length="522" mass="59477" checksum="FC85446335444702" modified="2023-02-22" version="1">MGNKKHYKFHDFHSPALDDPDFTAKPMILLVGQYSTGKTTFIRYLLEQDFPGIRIGPEPTTDRFIAVMDGDEEGVVPGNALVVDANKQFRALTRFGNAFLNRFQCSTLKNEVLSSVTIVDTPGILSGEKQRLDRGYDFSGVLEWFAERVDRIILLFDAHKLDISDEFKRCIEALSGNEDKIRIVLNKSDMVDHQQLMRVYGALMWSLGKVFKTPEVSRVYIGSFWNEPLHYDVNRRLFQDEQHDLFSDLQSLPRNAALRKLNDLIKRARLAKVHAYIIAELRKGMPSMIGKEKKKKELIAKLDKIFEQIQREHNISPGDFPDINKMREHLQNADFTKFNPIKPKLLEVVDAMLATDIARLMAQIPKEEAIQVANGITPKERETVHGGAFDRAAEMETPFGFGKGEGFDKGRDESEWVVSRERFKFDEQFDSLSPVDGKVNGRTAKDHMLKSKLPNSVLGKIWKLADVDKDGFLDADEFALANYLINLKLEGHELPNELPKHLMPPGKKDLESSEGVYPQLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTC1</accession>
    <name>A0A914YTC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTC1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2914.t1">
        <property type="protein sequence ID" value="PSU_v2.g2914.t1"/>
        <property type="gene ID" value="PSU_v2.g2914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2914.t1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11959" checksum="E4B89440F81F9F1F" modified="2023-02-22" version="1">MNAQEILYKFQMEKFEIFKSQDPENGKFDVVFEIDGKKLYANKYMLCTTSTTLESMLSDRWTKSNEPIPLHGHTFEDFKEFLTFLYSGKCSLTDNSIFAMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTQ1</accession>
    <name>A0A914YTQ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTQ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3535.t1">
        <property type="protein sequence ID" value="PSU_v2.g3535.t1"/>
        <property type="gene ID" value="PSU_v2.g3535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3535.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23966" checksum="4860BA2031FE6A11" modified="2023-02-22" version="1">MEDPNKNDRILSEVSPADLKVKKNLEDDLKKAKDIAELGAQAINSAYIASLFDSEMSLAGLLTENPLLSDIYKNVQKLVYYSLKLKEDNLKLNNRVTNLLESSDNNNSKTIVQELQASKSTLEKENAELTEKIKIMKKSNEEWQQKMETLNIKVQTAKEKKKNLNVKDVETATEKLEEDVEVQTLKTTVQQSFKCKKHFGRRGFSCCYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTR1</accession>
    <name>A0A914YTR1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTR1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3053.t1">
        <property type="protein sequence ID" value="PSU_v2.g3053.t1"/>
        <property type="gene ID" value="PSU_v2.g3053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3053.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12071" checksum="6074587A97619230" modified="2023-02-22" version="1">MSWQDLVNNNLIGTGNVSKAAIVGFDGSVWGKSDNFNLDQAEATQAAKAFVNPDAVLASGLRFEGQKYFVLRADDERVIGKKQGDGFFLYKTAQVIKDIKLLISVKKLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTT6</accession>
    <name>A0A914YTT6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTT6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4081.t1">
        <property type="protein sequence ID" value="PSU_v2.g4081.t1"/>
        <property type="gene ID" value="PSU_v2.g4081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8 10" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="210"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4081.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="50750" checksum="E39F263C10CA6C1D" modified="2023-02-22" version="1">MFGYGAITFPAGIGQYLAGERLFGETVRDFFGNCSWVLSNTSEPFGCTQAQLGVWSNNGRSMPMDVLMLFFVFSFIFITLCSTLPVPLGAFVPSFVIGGSIGRAFGEALLILMPHRAAIIFPGIYAVVGAAAFCSGATHSVSVAVILYEVTGQLHYTIPILIGVIVAHAVGKHLQPSIYDSIVQIKKLPYLPDISHISQDFIGITAEQFMVKDVKFLSHDSTLADVREIIMKFPNVHTFPICDSNKNQILIGSCKRTNLRKIIDRTIGPKAYSAELARRLTNVNPDGTNTSTHSAPSATDLDVVNGDPNPTSNNKGEKDSLLSKDQQPSTITGWKLRSFINRKKNHDNGVFGFNSKERAIWEANALEASLELNEIEFDSAPFQLMERSPLLHVHMLFSLLGLKRAYITKCGRLEGLISRRELRKGIEDVRQGILVARRISGKLDPSLFTVASVKPELQFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU06</accession>
    <name>A0A914YU06_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU06"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20942.t1">
        <property type="protein sequence ID" value="PSU_v2.g20942.t1"/>
        <property type="gene ID" value="PSU_v2.g20942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20942.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="18299" checksum="779063D6C340CC0E" modified="2023-02-22" version="1">MNDAQMHGNNGGGYVPLGGIMPSYGLAPGPPSQQQQYSQQAQQQQSINEMMFSGMPPPPPQQPQQQQYISASGGAGGGGGGYDRPPPSLAPGAPIGGGPGGIPMGPGGPAGPGGDDGSGGPPGPPIAPQFQCPRRPNIGMEGRSIVLKANHFKVGMPAANIHYYQIEIQPDKCPRKVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUQ4</accession>
    <name>A0A914YUQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme NO-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUQ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4352.t1">
        <property type="protein sequence ID" value="PSU_v2.g4352.t1"/>
        <property type="gene ID" value="PSU_v2.g4352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1520.10:FF:000005">
        <property type="entry name" value="Soluble guanylate cyclase gcy-36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme NO-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4352.t1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22499" checksum="8AE3EB6FA01F5B0F" modified="2023-02-22" version="1">MFGWIHESFRQLVTRKYGRETWVKIVTLAKFEEGLEPDIGHYYKDEDTLRMVHAMGNVIGIPIEEVWEAYGGFLIQFTMETGWDELLRAMSSDLEGFLDSLDSLHYFIDHVVYRTKLKGPSFRCDPQNDGSLLLHYYSRRSGLYPIVKGVVREVARRIYDTEILMRVLERKQEHLETFVMEHVVFVINQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVM8</accession>
    <name>A0A914YVM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4634.t1">
        <property type="protein sequence ID" value="PSU_v2.g4634.t1"/>
        <property type="gene ID" value="PSU_v2.g4634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4634.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15704" checksum="BE96BBCE38317637" modified="2023-02-22" version="1">MASQQTPKGDNPSSSQNVRKDNLSDHGNLNLLNQNQNQNVVPVISHTNSSHSHPAAPVIEETYSRQHQVSYSTAPSTSGSNFNSILNPIPPSTPPRPIRGLVARAQNMTSEELEEFSKGFEEQAQSYQSTPPKKKVKFLNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXC4</accession>
    <name>A0A914YXC4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exocyst complex subunit Sec15 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXC4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4757.t1">
        <property type="protein sequence ID" value="PSU_v2.g4757.t1"/>
        <property type="gene ID" value="PSU_v2.g4757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4757.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15335" checksum="23797E1C409DDCD2" modified="2023-02-22" version="1">MQTCKYLADQLHSALLSPDVKAVSMGALDQFSLDVMQCEMFTAQCPVVGFDDATLSITFAHLRQLLDLVMHADWTTYLAERTQQNSKYARVKASDAATLLEKMIEFEKKNSSFFSRSGDRKKLYDTILRQLRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ72</accession>
    <name>A0A914YZ72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ72"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4932.t1">
        <property type="protein sequence ID" value="PSU_v2.g4932.t1"/>
        <property type="gene ID" value="PSU_v2.g4932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36649">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36649:SF28">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4932.t1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43325" checksum="84F78D974B6F2EAA" modified="2023-02-22" version="1">MSKPPIKKTKISETVVSNIMDEYDDDEEEEEEEDGNDDDDVEPFRVAFTKHLYEEDEPEPIELPTWLIELKVQIMDGKSFKIKVNQFSNVSELKKAILKMHSIPPNHQHLFYNCKLLNDGHTLIYYEVDNGVTLKMYVAKTVERCEFYSIRADLLDPEAEQLELPTETLLSLCHFGQTRPPSNSHAELTIQIMNGQSFTIFTSTINMVGKLKEEIAEQEKIPIEHQNLFFNVTRRFAIKVRGKYEDMKWLGQPSTSTREIPGEWPMAYHGTSEVNILEIVNSGFDLRKCVRMAYGKGIYCSPDPKTALWYSKDYSCEINKSGTYRVILQCRANPEKIKVVRAADNRLGEYWTVPDGADLRPYGVCVYFYPVGKMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZN3</accession>
    <name>A0A914YZN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZN3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5955.t1">
        <property type="protein sequence ID" value="PSU_v2.g5955.t1"/>
        <property type="gene ID" value="PSU_v2.g5955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="145"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5955.t1"/>
        </source>
    </evidence>
    <sequence length="551" mass="63243" checksum="5CD566922E9D9817" modified="2023-02-22" version="1">MNKPKIEINFIQKHLLIPPSKCDRIARRIYDLQRNFNVKIRFTNNQTSNLTITGAPNKVAAVHQRINNYLVDLPSRDGTSFSSYPVAFGYPSLFRRNLSPAKCGGPHSASYGLRQEISNDPPSESASSTLATVLNENTSDAQNPQLFECSICFESFKIEEKCIKCSKHSEVVGVSDDIDEEGHTICIECIKRYAHSSITENSVAFGGIGLKCVEFECENTFLLSSFESFIENIDCIPLMERLQQQCIIDANLEDLVTCHECGYKVCVPKNNQYYICECGKKNCRKCPRLFDHKHFGKTCQQMDQEEANNVILRNLESKISEVVIRKCHKCGISFVKNEGCNKMECRCGAKQCYICGKQDIEHSHFCCCGNVTEKHGPCSKCKRSCRSWENYEEIDETKIDTILSSFSNLPQNIRQELRQSHRPFSSHGLPEVTFQEAFGNRLLRRGENVEQIPEFNRYIPPPQLLLPLQPLPNYQHQFRQPYMNYLPSNICITTTPPFHPTPQMQQQQPSMNFQNYYPIFGYPSPLVPQQQQFMAQQNYFYQNNFVNPQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0J0</accession>
    <name>A0A914Z0J0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5397.t1">
        <property type="protein sequence ID" value="PSU_v2.g5397.t1"/>
        <property type="gene ID" value="PSU_v2.g5397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048643">
        <property type="entry name" value="Itf52_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21178">
        <property type="entry name" value="Itf52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 central" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 52 C-terminal" evidence="2">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5397.t1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19450" checksum="07441B02906B1A43" modified="2023-02-22" version="1">MKAFDSSLYALDLDLWPEVIRAYEKVNVPYEPLTIVKPSLEVPLPPLQPAVFLPGFRELPPPQLELFDLDDAFSTSESRLAQFATRCTENEVERFVKEAGELLGVGRGLPANERTAKRILELVVAQLIEFKRGQPDAEAADDGHLFATVEDHEEEDEEHYFSDLDEYDDLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0L1</accession>
    <name>A0A914Z0L1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0L1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5690.t1">
        <property type="protein sequence ID" value="PSU_v2.g5690.t1"/>
        <property type="gene ID" value="PSU_v2.g5690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056967">
        <property type="entry name" value="Fn3_Dep-1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056968">
        <property type="entry name" value="Fn3_Dep-1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057482">
        <property type="entry name" value="Fn3_Dep-1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056970">
        <property type="entry name" value="Fn3_Dep-1_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056966">
        <property type="entry name" value="Fn3_Dep-1_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24942">
        <property type="entry name" value="Fn3_Dep-1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24943">
        <property type="entry name" value="Fn3_Dep-1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25300">
        <property type="entry name" value="Fn3_Dep-1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24946">
        <property type="entry name" value="Fn3_Dep-1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24940">
        <property type="entry name" value="Fn3_Dep-1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="218"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5690.t1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60542" checksum="DA201571DFC469AD" modified="2023-02-22" version="1">MLNVIYFLATPDLPKYLHDFPESFKIQKDPTDPSRLLNVFLPSNFEKFKQFIAKVTDISPEIEYPIKDVNRTFLASPTDSSVINVHGLNAGHQYSIAVYGRIEGDSQLIKEESVIMDPLSLDFHSHGSSILVTHNNITMRTMKPEKALQDTFRVEYVQLDPPKRYPILDVHDIMEQKDVELYLGNLNPGRDYDVMVTSLRNGLPSQPWKGVITTRPLKPGQLLVQEINATCVNFSWILPAESGADRFKIAYGILKDKTDNMIKIEVQYSQQQIELCNRIIPGYPYIFVVIAEKSNQISDASTISHTIKPLPAEDLKIVPDFDKGKYRIETILPSKSQSKIDKCLITVSSEKLEKMEDISKVEEFDNEKVRCISYMALTPGQRYEISAATQSGQSVGTKIFRSLAVDPGFNMKAFGLILAENKGILRLEWPPSEVSMLKIKDLWAKIVGNATQLHLKVDPHIYPTSASTSSLIGQAGLEAQMKDSVRQVETSPSASETSVIVDHLRRGACYKIQMYTVTSSGIVSTNRFEQYLRMSAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z250</accession>
    <name>A0A914Z250_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z250"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5975.t1">
        <property type="protein sequence ID" value="PSU_v2.g5975.t1"/>
        <property type="gene ID" value="PSU_v2.g5975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053124">
        <property type="entry name" value="Notch_signaling_modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35015:SF1">
        <property type="entry name" value="NOTCH LIGAND OSM-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35015">
        <property type="entry name" value="PROTEIN CBR-OSM-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5975.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24568" checksum="2445959476B60CB6" modified="2023-02-22" version="1">MNLVAIACQRNPDLAMCAGNSDDATFRAFDAPEDSETRNMRSFPKLDFDELQVERYCDRHEEHYLHYCAGEGTIERQLQSKILKFCPSFEKYCPEIATKLNSATIKRSLDSFRDSGIPLVEPPPLPSSSQMGGMSFDSPISDSSDRLDQIPQRRPEAALSPDLIKTCTPDCTAPHCTRECKCANTHPAVHAKCNPPENAALAGVCQAWYNKCPMFRPVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2S9</accession>
    <name>A0A914Z2S9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2S9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g619.t1">
        <property type="protein sequence ID" value="PSU_v2.g619.t1"/>
        <property type="gene ID" value="PSU_v2.g619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g619.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21810" checksum="7B0D527BD3E35160" modified="2023-02-22" version="1">MAERSKRLSTATAELYYDDYIQRRNKELAKNRPSSKNSQRSVSSGSGVRPNSKSSNRISTGSSRKSSASAASKIDGPKPYEFEAHKYKRNGYKNFDTQLGADPVTAIRTLKSRLRELSISSATIDRPVKSQICQQACDKLTEAEVEMGNLSHQRSQAILHGKVEDAKKISSQMSELRDRVTYSAYTDLLIDRDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z307</accession>
    <name>A0A914Z307_9BILA</name>
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        <submittedName>
            <fullName evidence="4">WASH complex subunit 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC53 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z307"/>
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        <property type="gene ID" value="PSU_v2.g6734"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015">
        <property type="entry name" value="PROTEIN AD-016-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6734.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24822" checksum="79407977BC9BF324" modified="2023-02-22" version="1">MSREPDLSFIQPDVNLKDVSRLETKKVIHLTNEFLLRIADISNSFMQNMETKIFELEKKLEALDTVLILVETKLENIESKNTVDNLPPPVSNFEEPKVIVTEPLDNVTTISDSIPIPKAPVLPTVVVQEPHNNVQQEIVPSAVVAEIIDERKIKISEHPTFSKYFKMLRLGIPELGVKQKMTSEGFDANLLDTPNALIDPPSAKPQDSDEESDSDSSFSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z351</accession>
    <name>A0A914Z351_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z351"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6320.t1">
        <property type="protein sequence ID" value="PSU_v2.g6320.t1"/>
        <property type="gene ID" value="PSU_v2.g6320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6320.t1"/>
        </source>
    </evidence>
    <sequence length="380" mass="41573" checksum="92D132F26AECAC6A" modified="2023-02-22" version="1">METLIATTEAAAAAAAEINRHESIPSKVTTTGGDSGAFISSLSIDILQPPLSERRRSNFSSRASTVSECESLKLEETIERLEEVVEKLTARETASSIELDKSNPFDEPLSDAEECCTNDYGGGGNCEEDGEEEEEEEIDQFPDIIFLPSLPNSNTSTVRVTDRSAASTVSSGMASEEDFDYDQTKNPFSPYFRPSAKKASQPNPFECSSFVTDAFTTPPIIPKLDLQEHFSTAARPSEALNILSKTNNNNNPNPFRVEAWGPDSRDVQTARVDAWHQTSIDSDDEDAVAAAAAAEDDIYEVEIKEGSHSAPNTQRKLAPCAVTYPQTEAFINLVMGDIHGFMEIESTAKFYPDGCFTVSSPFLISDFGNPNKKYILICHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5C0</accession>
    <name>A0A914Z5C0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5C0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7880.t1">
        <property type="protein sequence ID" value="PSU_v2.g7880.t1"/>
        <property type="gene ID" value="PSU_v2.g7880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7880.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14317" checksum="1DE65AA0C3B25378" modified="2023-02-22" version="1">METYIVAFVLVIVLYVIYEIHKNRRRHGKRGIPILGYIFDSFTLSVCEENDCETSGTSKSGKKSGEHKKHHHKHHKHHKCSKHHKHPKSKQLQLGSTALDLVEDNTQRSEMKSSKALKGVPINNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5Q5</accession>
    <name>A0A914Z5Q5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5Q5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7676.t1">
        <property type="protein sequence ID" value="PSU_v2.g7676.t1"/>
        <property type="gene ID" value="PSU_v2.g7676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7676.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10646" checksum="6737A074F98A7302" modified="2023-02-22" version="1">MKDNYDYGKNDNFDKAKTSSTNESTLSLHIANYENSLETYGNDSEGDEEEAALKIKKNEKSDMIKSWKNAKHGLTGAFSEVGVNFTFFGDGSVMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5X4</accession>
    <name>A0A914Z5X4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cleavage furrow</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5X4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7348.t1">
        <property type="protein sequence ID" value="PSU_v2.g7348.t1"/>
        <property type="gene ID" value="PSU_v2.g7348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="35"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7348.t1"/>
        </source>
    </evidence>
    <sequence length="428" mass="49092" checksum="E0674FF00BD376EC" modified="2023-02-22" version="1">MVVDIQREPSQASTKSEFMGFANFPNQVFRRCIKNGFHFTIMVVGQSGLGKSTFTNSLFLSEVYDVKPHQMPIPSTVKIDSKTVCLVENDVKLYMTFVDTPGFGDAVDNSNCWDPIINFVDQRFADYLAEETKIERPENIADNRVHLCFYFIAPTGHGLKELDIEFMKALQDRVNIVPIIAKADTLTHQEMLTFKQNILKDLDTHEIRIYKFPDQEGTIVGIKNAPTKCEDNRKRIPFAVVGSNKVIDIGSKRTRVREYPWGTVEVENLAHNDFLALRDIVIRSNLVDLINVTRDIHYENFRYKQMCKGAKGNLERDPFTQLEEERRTVEKEAAEVRRTKEKIFAEKVADREHKLADRGKALDEQEKENRRILHEKHGMLQKSLEELSEFRRAAGINDSGSSIGHIGRNSPPDGKKKKSSTLNIFNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6F4</accession>
    <name>A0A914Z6F4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z6F4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7909.t1">
        <property type="protein sequence ID" value="PSU_v2.g7909.t1"/>
        <property type="gene ID" value="PSU_v2.g7909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041201">
        <property type="entry name" value="PTPRJ_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18861">
        <property type="entry name" value="PTP_tm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTPRJ transmembrane" evidence="2">
        <location>
            <begin position="241"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7909.t1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43701" checksum="ACDCC7A43C31BCAA" modified="2023-02-22" version="1">MAAKLYTLTVRNVSRELEIASPAKGLRQITPPIITSTVYPGQISNNAININFGESDPEHSFDTYELTFSGSAKNITKKLKKDDEKSFTFNKLIPGKTYHFELFTLYRGIRSRPVIADITTYPLKVTKLYPVLGPGYATLFWDIENVADNDCRYRLGFTTDNSMFKGQSVELKNIDHYRFNNLEYETYYTFTITVIMGSGEAEAESESESVTVAFAQEPTSSPSLQRYGSRELSITFENDQRIFTELNGEIKNFAVIVAEDLKKPGDAFDLKSYYEIKNEDKWPAYRASSSNYNPFNNGKTKSATFIIGEEDCDRRRLDEPYCNGALRSHTDYYVKIRAYSVANIAMETEWASVNGLVDEAPKGSLAKCASMTILSIIGEMSLNDTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7A9</accession>
    <name>A0A914Z7A9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z7A9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7793.t1">
        <property type="protein sequence ID" value="PSU_v2.g7793.t1"/>
        <property type="gene ID" value="PSU_v2.g7793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="114"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7793.t1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32172" checksum="1861452B518318A1" modified="2023-02-22" version="1">MPERPEQKEILEKEMKYLVMKNRAVYYFNEEESDDLRLLVPYTLRKKVVNEFHEDALQGGHLGQQKTLEKLKKRVYWPSMTTDIKEIIKSCAVCQKSKVNAGNRSREPLQPIEPPTRPFDRIHTDICGPLPKAMDKEQYILVTIDAFSKWLIASPMKNQTAQTVSTTFINDVITKHGCPNSVTTDCGRQFTSTIFQEMAEIFGFEHNTSTPYHQEANGEVERQNRTLATMLRGSVALGGDDWPETLQMATFAYNTAVQSSTHQSPFFVIHGREPRLPTGCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7M7</accession>
    <name>A0A914Z7M7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7M7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g625.t1">
        <property type="protein sequence ID" value="PSU_v2.g625.t1"/>
        <property type="gene ID" value="PSU_v2.g625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g625.t1"/>
        </source>
    </evidence>
    <sequence length="708" mass="78677" checksum="2A787110AE99C35D" modified="2023-02-22" version="1">MKVSFKFMSVSSSFIHSVDHPPFALVPNDTVPLVTRLARRKRCTCGCSGCDLFPNRACCGSDCCSSEPVPLACCPPPPPPKPCCQPNFGPCCPATPNCCKKPCCRGQRPDIYEDEDDFGAPPPVPPATDRTCCPPATPVQPAPPPVPPPPPPEPPVECCAPPASKKSPCGCSNCGCGRPCCYYRDAECCRTKPCCPPELPCCPPLPTLPVCCNMAPPCLRACPTCPCRKRIHLGTRAKRQGFPGLHCQQCLAPGANTAPGAPKQYAANTVVVTTTPKSNPLLEPTEPRDIVEEAPRARGGNLFERNRHIRVKRAGCQVCIDGRPLKREKRHACVQCSYLHPVYGNTPNSSPYGDGNRIQTPVPIPLQQHLREKRNGCIPPPTCLTMRRRSKRNFNSQYCEPCPNGFHGRVKREEERQQCMDRRKKRATDGEQNCEEEDSHEFGSSITRMKRQAAYSPNGALDIMKVLSKLTTNRAVGGGGCMEFPACVLAQKKRRKRHAARVIKHQKAMKRYKRAIKEHEKVVERHKRQFFAPDAAGANCAPCPAWVTLALTSRKKRDTEQSTADLEDIKYALKDIRRRQKSLLYEEDECEQTGDCMNDAEYGEFMRKYHLGKRKKRQSSSFTENHERRRCVHCHGKQSKGRAKRAFGGPTINASAGNCYAFPACRTRVKRHNFECNVCTSSANPLKKKKRTKRNFGSVQCYPCGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z888</accession>
    <name>A0A914Z888_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z888"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8108.t1">
        <property type="protein sequence ID" value="PSU_v2.g8108.t1"/>
        <property type="gene ID" value="PSU_v2.g8108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF32">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8108.t1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45371" checksum="E6B1FD5D78A3A91C" modified="2023-02-22" version="1">MPAEIDTSPPEKHVQSLPVVGSFYLRFGAFIFAIVACVYYIFSAHWGIFTAVDICAIIFTIFQTHLLFFSSTMFDEKVYIISCFGTMHLVAVNLITWVQFLFAKNQSTEESIAKYFKKKKNVTDKIITGITTTISSLNSNEEDFEEFQRSVPSNSRSRIPYNSECKGLECVFGLLWGLLFVIGTALSMIFFYVNWYHDEHKEAAYNFNITDIVQNGIGMIACIFAFWRLRLLDFAHHSSHDPHHDIHANQELLDMILLAIGIIGELAFSISGLAGICSNKAWNTLTILLAIARILRIIQSIFQTFLIAFASKLKSTDPDRHPGRQTITFLIILNMAMFIYQWFISDKAGTYEGVISLYGEESWAFFVSIFSPLTVFFRFHSSVCFVEIWKHTYAKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8S7</accession>
    <name>A0A914Z8S7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8S7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8737.t1">
        <property type="protein sequence ID" value="PSU_v2.g8737.t1"/>
        <property type="gene ID" value="PSU_v2.g8737"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019428">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Str"/>
    </dbReference>
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        <property type="entry name" value="7-TRANSMEMBRANE DOMAIN RECEPTOR C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22943:SF248">
        <property type="entry name" value="SEVEN TM RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10326">
        <property type="entry name" value="7TM_GPCR_Str"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8737.t1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16675" checksum="B3195A3DEAD24BD6" modified="2023-02-22" version="1">MVILRYKINQKLMKYKLSMSHRSYKARKQLLMALIIQMIVPLIFIVIPVGGLYICIILEIPDIEDLSQWVLQFFGLHSCGNAITIITMIKPYRQAIKNAFKRFKCLLFRETSPTISVSATAVSYPPSLAIPVTKTTSRMYNRFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z929</accession>
    <name>A0A914Z929_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Propionyl-CoA carboxylase alpha chain, mitochondrial</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Propanoyl-CoA:carbon dioxide ligase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA. Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA. Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z929"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9177.t1">
        <property type="protein sequence ID" value="PSU_v2.g9177.t1"/>
        <property type="gene ID" value="PSU_v2.g9177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041265">
        <property type="entry name" value="PCC_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18140">
        <property type="entry name" value="PCC_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0092">Biotin</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="23">
        <location>
            <begin position="57"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="176"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="21">
        <location>
            <begin position="649"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9177.t1"/>
        </source>
    </evidence>
    <sequence length="724" mass="80228" checksum="013657D493AC1775" modified="2023-02-22" version="1">MRFTTFLSIAALKRSSPSLIIPRYNQNFAKLFSTAEDKGTYDHELYTLDPINLKEPKFDKILIANRGEIACRVIKTARAMGIKTVAVHSDVDSNALHVKLADEAVCVGSAPTAESYLRADRILEAVKQTGAQAVHPGYGFLSENTKFAAQLEQAGAKFIGPNSKAILDMGDKIHSKKIAAKAKVNMIPGYDGEIKDEEECVKVSNDIGYPVMIKASAGGGGKGMRIAWNDKECREGYRLSKQEAASSFGDDRMLVEKFIDNPRHIEMQVLCDKHGNGLWLNERECSIQRRNQKVIEEAPSPFVDPDMRRRMGEQAISLALHVGYDSAGTNFYFLEMNTRLQVEHPITEGITNIDIVQQMLRVAYGHKLNIKQSDVGINGWSFECRVYAEDPYKGFGLPSVGRLTKYEEPLNVPGIRCDSGIREGSEISIYYDPLICKLVSHGKNRKEALDRISTALDHYVIRGVTHNIPLLRDIVEEDRFRRGDITTKYLQEVYPEGFQGATLSADEERKIIAVSSALNARKVARAQQYTNQSRQKSTLVNPYSKHYSFVVSLGEGVEGKKKQVKVEAFFENGDPEKARVKIDGKEIAVNGNMNLASSVLNLEVDGKPLVTQISSKKAGVFTLIYKGSPFKLSVYPAIANEYVKHMKEKPKVDLSTVVLSPMPGAIKSVKVEVGQMVAEGQELVVIEAMKMQNSLHAGKTGKVKAVNCKEGSTVDEGEILVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9J3</accession>
    <name>A0A914Z9J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell cycle checkpoint control protein RAD9A</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9J3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9343.t1">
        <property type="protein sequence ID" value="PSU_v2.g9343.t1"/>
        <property type="gene ID" value="PSU_v2.g9343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9343.t1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48007" checksum="0FECC4CDB170318E" modified="2023-02-22" version="1">MTQESECQRFHGSPNETQTQTIPAHYVFNEKVEIFADTVKFIAKFSDSLMVEFGDGSLYIEALTATKSAQANALFEGNSIAEWSYGDLGTIVDKRIQLSTKQFVGALRSVTKHDTLYFKIKGVSCNRVAIEYTNNRDVVRQFELQARDVSLTYNKLKCPRHQYSNKIVCSTKFFKVLFAQLNETDEMCLQFYPDHSVITKFINETNADNVATLHSTQSRDSYELYEIAVPMSLVLSVRELKVALKLINVHSFLVHIFFGLGGKPLLVTFDDENKDEKCKALISIAEVHELTEEDEYEPIQNNSMSIAEVRDVNDQNDQGRLVERNFNSNDEIREINGENDHAELVERSFNSYDEMREINDKDEYEIVKRNSTSPYAAALRLLGIEDQISDPEAEDVLETYNLPATDPSEDLYILSQMPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9T4</accession>
    <name>A0A914Z9T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g9431.t1">
        <property type="protein sequence ID" value="PSU_v2.g9431.t1"/>
        <property type="gene ID" value="PSU_v2.g9431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9431.t1"/>
        </source>
    </evidence>
    <sequence length="410" mass="44507" checksum="04F3A518F89A1EB1" modified="2023-02-22" version="1">MPAVEAEIPEWDKLQSQINIVVGSVRGNAITITQLIKDIFATFGYDLTRAAHVHGYTSILAMLSDMVGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMLSDMVGYVKVRNTSEGSLVSAVVVAASAHVSAMIQKTKGTTKKNPKPMLARPGYQQPQSSRGRRQGVSSNYVPRVAVFGSSNPLFCASKSQYPVGDSSSRGQPSSSHIYRPAPPYQSPLVRPAFSQDISAQLPSSPQTSSVHTSPYQGFRPVLLSSSSRKSTMSSSLSTELSTIKNSGFQPAPFQGLWLASSSSPALSQSLESTEERTTVHGSTNETFKLLSPFSEKSRRPSSGKVIPAVSIEELNYWREVHLGSKRPVPPPRPSIVKPQGSDKPRILSPSEAVIWVRIILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAA2</accession>
    <name>A0A914ZAA2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine and histidine-rich domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAA2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9249.t1">
        <property type="protein sequence ID" value="PSU_v2.g9249.t1"/>
        <property type="gene ID" value="PSU_v2.g9249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="5">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9249.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35506" checksum="01CC9F7E9EAC10FF" modified="2023-02-22" version="1">MAQLCCYNKGCGKKFDPAKNEEDSCKYHPGPPYFHDAYKIWKCCDKKFTDFGTFLSHPGCTLGKHSNEKVEDIVRLSATKEIRPEKKEEVIVWSGLNKPSERSLASGRMQNLTKEITPGASAAVEKYLAIVKEKENNGEIPIGAACVNNSCKTTYNGPETNETSCIYHPGVAIFHEGMKYWSCCKRKTSDFSSFLSQEGCTTGQHKWSKNERVDKIREDWFSRLGFIHLNVYCKGSMGDQCVFETDGLTLRTTIVHGFGDKITDKNYDLFGAIVPEESKIIIGERKIEMVLKQAEPIGWPKLVYIPEENQVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBI5</accession>
    <name>A0A914ZBI5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBI5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9673.t1">
        <property type="protein sequence ID" value="PSU_v2.g9673.t1"/>
        <property type="gene ID" value="PSU_v2.g9673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9673.t1"/>
        </source>
    </evidence>
    <sequence length="513" mass="61028" checksum="55313013816363F3" modified="2023-02-22" version="1">MESETKETLIDDDEKEFNNLITRGITMHFEDDEESNEKNNKAAEEEEEKLECVVEGIIPFKYVGICGPYGERIVDRAIPLRDPLPNEKPPIVYDIEEIPKHLIADKQGFFGLIELAKKEIVIIKTDRTADGHLKGYYGGRITENIYYPLEIHDNMVHMGYKHLFKQWNQSIFDFYEKYHFLPRVPEHRKQPQYLKYRYFDPNKTFYENLDFFLIDTFFQRESRNGADVLLIKDLSEVFWTAVLLERRILIYTFHNETIEFKRKLQIYSFVKRMTIFYYPAHREADRYFDRYGKPQINLLPEIMPPVHDIYIPAEDFFELYEYNYTNICPITDNYLCNTFVPLHESEGMPCYCALIEPFDTDPRYEWDEGCIRRSEFVENLQYISLTISSFIPNELVPSNAHGLLFAELITVALVNATILPGAFQPKFLHFNPTVIFRLHCSSLMQEFTIQFGIITRKFTIADDNIYETDYLFLSPKRFWEEVEDQNTLQYLENMGIKIVRYGIVRIFDLKIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE24</accession>
    <name>A0A914ZE24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IgGFc-binding protein N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZE24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9914.t1">
        <property type="protein sequence ID" value="PSU_v2.g9914.t1"/>
        <property type="gene ID" value="PSU_v2.g9914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9914.t1"/>
        </source>
    </evidence>
    <sequence length="333" mass="36568" checksum="B78E8FA090B05741" modified="2023-02-22" version="1">MDGQKGFMITPGFTGGMASTDVSHFYNIQYPYNISVNVKVKAFRGNPYVVFQSQNIDKWINTTLTSDIKSFSENATSFGLYASEKPGEGVLLEYSFNDYFHPNPIYVNINAANPTFVMWLDDMKVNDAYTVCSSGGKLAIQVTSTIDKNALSKYRLFDSTSTLTNYTTDLNAISTSSSLNGYVPGNFKSKSGCFTLFREPGNNTYATALFSIPSIQNQNCISEGNVLQTKNHSLSSDDINLFQVGASHSGPCEMIILTSQNSLPLISIENVSVTADTYFVFKNLINQKQLFNLSSNDATSFKKVGIYSNALSIMIQAGTIMNMLAYNSNGTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRZ5</accession>
    <name>A0A914XRZ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear hormone receptor HR96</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XRZ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10050.t1">
        <property type="protein sequence ID" value="PSU_v2.g10050.t1"/>
        <property type="gene ID" value="PSU_v2.g10050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06966">
        <property type="entry name" value="NR_DBD_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000042">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF508">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="662"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="543"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10050.t1"/>
        </source>
    </evidence>
    <sequence length="896" mass="98809" checksum="02039D3863BA6EBE" modified="2023-02-22" version="1">MGVGLAPGHQFPTNFAGIGIASNAAQLSSSLPSTSNADGILPQDSQQSTQSNNIGIGPRKRTFSTSESQPAGDKRTATKICRVCGDKAYSYNFNVITCESCKAFFRRNANKEKDIRCPFNDQCDINIVSRRFCQRCRLQKCFRVGMKKEWIMSEEARMEKKQRILDNRERRAAERKSDDGPPALSSQQQQQQPQQSQHQQSHHHNHNHKISNGSSAAEELAAAINAASAQQVPILQQQQIPPSQPAAPTLATLLPTAATAFTSPPVLQQQSGPPQIPAPTEVAAQQLAAAVAAVAHQNPVAAAAVVAASQLPPQAFHPSIQNNPGQMATERALAASIVANASVPTTDYPTASSSLSAAAAHQQQQIVSQLVMQNQLQQQAVQQMAAVQQAAAAVQAQVQINHLQQQAHQQAHQQLAAAVVAAAASTMVPTEIQQQQQQNSMNYSNAPVPQTVVTVPSLQQQSQQVIPTTTVVTNDPSTDLVAVPRDVLIKLVEQKIESEQQAQQQAGGGMAPLKCQCHCSCGRYPSELLIVDKVMTDLLENSTKYNNSKPMGQLSPKSDQQTPPTLMSTTPPSFYSQTNPLQTLSGPSGVAYHHHHPQHQHQQHLQHHQICTPAATVGNGLPIPMEEDYVFKKSQSDAAKVLLNSKMEKCLVDPDCCMLTNSDIEILNELQNANTIWDTVLDKKDSERHAKPCHTKLDLVNMADGAIRRLVKMSKKIFVFRQLPYDDQMILIKYNHMGCLILRGALTYIEAENVWSGPSQKSNYNIKLETMKESKFDLMGSAVTFYVSMRKEWRTNESIIQILIAICLFDPSAANLLYHADVRLHNLRYHSILKRKLFMLCEKDQRKACQEYDLLMKNLVELKNLSYQAFKFVDEIRDCPLEPLVKELMLDLSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTM3</accession>
    <name>A0A914XTM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10614.t1">
        <property type="protein sequence ID" value="PSU_v2.g10614.t1"/>
        <property type="gene ID" value="PSU_v2.g10614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF338">
        <property type="entry name" value="CYTOCHROME P450 CYP36A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10614.t1"/>
        </source>
    </evidence>
    <sequence length="483" mass="56439" checksum="1041B89E24F96FC2" modified="2023-02-22" version="1">MIWYILFAIFIIFLFHQLYWRRRNYPPGPFPWPIIGNILMIDPNNFDHQLLKLKKQYGKVVTIWLPVPMIVILDAQLLKDTLIKQGDKFAGRPHSNLMVEFIGGNYGLIFSDNSFWREQKRFALHVLRDFGFGKSILEQTIIDQAQAVCDRLKILDEEPIDLTKLLTLSFNKTEDFDDDLVFNFRNEMLEIAAVFCHPFAFLLELFPRLKFLDPLFGGIYQRALNLNNNVMNMMRAHIKEHRETINFDEEPRDYIDAFLIEQKKQNPEMKMHGEWSDLQLLGAIYDLFGAGMETTSTSIRTFILYMVRNPDIQKECHQEIDKIIGRDRTIMMADQIKLSYVSACIHELQRIAVILTLNLPHLTTDEAEVDGYLIPKNTQVIPQFQSVHLDSDIFSDPEKFDPTRFLDSEGKFTKDDRVTPFSLGKRACLGESLARMELFLFCATFLQKFEFLPEEDGVMPPLEYQFGVLKSPIPFKIRARERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTN1</accession>
    <name>A0A914XTN1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XTN1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10328.t1">
        <property type="protein sequence ID" value="PSU_v2.g10328.t1"/>
        <property type="gene ID" value="PSU_v2.g10328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10328.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15977" checksum="1C53C1ED57CBBCED" modified="2023-02-22" version="1">MQNNRNQSQIVLWEGSPNYVSVYPIENDNSIVTIENAKILSYTGTKLNGNKIQYGPTESIAPFTSNNVSIQYEILPYKSQPTSVNKILTNIKAYKIETFLEGNILLIIILMAILVFICYLFFTRLLKKLRKPYVPAKKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTT7</accession>
    <name>A0A914XTT7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTT7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10677.t1">
        <property type="protein sequence ID" value="PSU_v2.g10677.t1"/>
        <property type="gene ID" value="PSU_v2.g10677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037364333" evidence="2">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10677.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13213" checksum="B44EB51315A98EE1" modified="2023-02-22" version="1">MVRKFIALVSIILIFFCTTSFVNGQGSDLDDVENSLEILTTRIAKLFQNLVLNLEKWLAKLDKHIIGLSGIVIFSCIIFIIGIILLCILAPCVYSVTSCIESCTHCCTGNKETRANEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWB0</accession>
    <name>A0A914XWB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10067.t1">
        <property type="protein sequence ID" value="PSU_v2.g10067.t1"/>
        <property type="gene ID" value="PSU_v2.g10067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10067.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11203" checksum="F7B1E55BA16B4FBD" modified="2023-02-22" version="1">MLIRFPALPQISKTTQDLADKIIEDASIKLHEYYTKELRVRDYAARQAKLYKIGIMVEGIIQNKTEMLKAWSLFNFGKNAFSFPKFEIDYFIYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX49</accession>
    <name>A0A914XX49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XX49"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12525.t1">
        <property type="protein sequence ID" value="PSU_v2.g12525.t1"/>
        <property type="gene ID" value="PSU_v2.g12525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="475"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12525.t1"/>
        </source>
    </evidence>
    <sequence length="761" mass="85169" checksum="0D3C5DD21E595296" modified="2023-02-22" version="1">MDTVDIEKLKVKDKNDKGNQNAAAAIGGDSKDQKLSDRKNSQEEWENISEEINIDYDNDNDNDKNEEGSIKTISDETSDDTIVELKDGKNNDGSGDDKFNKDILETSTDKSIDKIATENLNTVDVEKADTPKRNENDTNDGVLQSEIFVPGLPDVLINVEKINEVVEKEDTVFNPEREKTESDSDEDKTKIYSKSNGDIRRDNQKEDINARAPDESKNDNENRNEKLDQKNISKETVTNVKFEAASEGSTTEEEILAKQLVAEALENVEHFNSANLSEGYSGSSDDGDESSDKMDLGGKRKTSFRHMKRKRRDATPRPQNFLGGPRKSIDQESIPQKPPRQNEDTTTMTIRVTPPTPGEKLGSQNLKNVKRLPDAGAEEEFHEVAIDVPNPDKRQHITFDVDEDSIGDSFKKKMAELAEEDNDQPDQPYEKTNMEKFLNILLCRKDLVNQKLSEKPVRFWDLFKYGSRLDTILVIFGLLLAAMCGICQPLFAILSGRLANTLLLIEIDDPRFFAEGTQSCILFVVIGTILVTIAFIQFCCFNIACTRITRRIRNAYLLSILRQNPAWFEKNHSGALNTKLNDNIDRIYEGIGDKLGLLTRNMVQYVTGIIVALFFSWQMTLPLLAFSPIITFAMAFSSRKITQASRDEMKIYSSAGCIAEESITAYRTVAAFNAQETEVNRYKQELEKGVKSGVRKAVYTGALSGILISLVMVFMGTAILYGTFLHSIGVIKTPGDVFIVLMAIMSGAYHLGNASPHLMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ07</accession>
    <name>A0A914XZ07_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ07"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10912.t1">
        <property type="protein sequence ID" value="PSU_v2.g10912.t1"/>
        <property type="gene ID" value="PSU_v2.g10912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10912.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44263" checksum="5DFB885ED7E6DB4D" modified="2023-02-22" version="1">MKLEVNDCNLKHICPRYGRLEYFTGYTAGFKNHISVKQNVALKHLSFVPTKILSVPKTRDRQKKAEERTTASKGRLILTTDRSFQDTKRWKTKYKIHDYDFILKQSHEKVHKCQCCARCGTQCNDQLGIIETFMVMDFTQIVETPASETNTGKEAINESGPGEWKTLVKTKMCSECINQIKLDVLLHYDDIPLKHKTCEKVMNSGAFTEAHPKVQPFAQPFSLPFQISNMDVSTPECDNRLQFLQSSSGFNIHERVNEYTQMDGSIRYEEPQKQNSFFDYLNMDTQEEIYNSGVPIHDLSGHDLNWNGSNQQYHNNQFNPMEVPQSSDYYDNKNGVILQNLNSHVFVPQQSNVLEEQLQNFQNYFFTDEVNDEEFDRNEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZB8</accession>
    <name>A0A914XZB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12553.t1">
        <property type="protein sequence ID" value="PSU_v2.g12553.t1"/>
        <property type="gene ID" value="PSU_v2.g12553"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12553.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8703" checksum="C6A1AFEDC2F93C59" modified="2023-02-22" version="1">MDSSDLQTTNSTESLSSDISDISPMIIPCDRDIFLSTYRRQRFSLTDPIMYYIAKNPKNSKIYQKMVQSCKYFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y029</accession>
    <name>A0A914Y029_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y029"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13564.t1">
        <property type="protein sequence ID" value="PSU_v2.g13564.t1"/>
        <property type="gene ID" value="PSU_v2.g13564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13564.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12117" checksum="5C38CA7640C8A257" modified="2023-02-22" version="1">MEYGVKRSQAVVEDYDMSEFGLKKKRSQPAESESMDFGVKRKRSQPSGNQMEEFDFGLKRKRSQPMEQPTYDQEFVFVSKKRSQPIENQGNEDLASDPFIVHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0B7</accession>
    <name>A0A914Y0B7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0B7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11313.t1">
        <property type="protein sequence ID" value="PSU_v2.g11313.t1"/>
        <property type="gene ID" value="PSU_v2.g11313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11313.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9673" checksum="8D6E1F55FE60BDDD" modified="2023-02-22" version="1">MQLQIPAHLGQDIEQGLGLARLSAKLLIRVQDRIQATPGHQADQGHDGQGHQHFHQSEAFLARVCHGKDAKVACNSASTGPWGKKACTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0I5</accession>
    <name>A0A914Y0I5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-L-isoaspartate O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y0I5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13714.t1">
        <property type="protein sequence ID" value="PSU_v2.g13714.t1"/>
        <property type="gene ID" value="PSU_v2.g13714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF9">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13714.t1"/>
        </source>
    </evidence>
    <sequence length="380" mass="44622" checksum="E851516B5FC403FE" modified="2023-02-22" version="1">MDSDILYNQTMIRKLKATKKLHDSNITNALYSVNRSWFMPLRINDGTYEDIEYRSPSWFYYSDVPIHLFSPSLYVTILKQMDFQHGHSFLNIGSGTGYLSCLAGCLIGSSGKNVGIELQASLVHFAFIQRQKVIAFLEEADWGLPEILCLNIFEYKTKEKYDRIFVGASVKEHHRTFICRMLKNYGVAILAYYNELQKITNIGDNQYIVQTIEEVDFDEILEDDCKMPVKSCVYKPRETLDEWKKKVWEICQDYEAEFFIDYINGNACFYTFEEKANSAIKLIVGKYQIKYETRMMKQKQEKEAEKFGQELRKLKENQRMMEEKIEKVIADKENQDLEIKEFMKNENTSTADKIKNAKEFYGITDERSFNFAIAGHTKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y297</accession>
    <name>A0A914Y297_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal transducer and activator of transcription</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y297"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14298.t1">
        <property type="protein sequence ID" value="PSU_v2.g14298.t1"/>
        <property type="gene ID" value="PSU_v2.g14298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09919">
        <property type="entry name" value="SH2_STAT_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14801">
        <property type="entry name" value="STAT_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000493">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47655">
        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0010">Activator</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="469"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14298.t1"/>
        </source>
    </evidence>
    <sequence length="691" mass="78858" checksum="6C18C17FA001B457" modified="2023-02-22" version="1">MMHYADVKNGLLELAKECQVLWEENKDTQARFVNYLAELQRYQMAIGQLENEGKHDQAQNFRSTMMENQKRASTLYEQLTERRMTLVKKLNDGVHCIVNLQQHLINDRLFEWKNHQKLSQIGVPFDTRDMALDDIQMEFELLAETNWQLRTFACWQLDLLGRSPQLSDNTAQSHITNLKTVLDSLTKMLCVLVSQSFVVAVQPDPVLKTQHKFVAEVRLLIGDKLGIKQHLVNTNVTVKIIAEEEARMLSNGQISEKDVKTVGTISNDFEKLTHDEKGHMAAKFNNSKLTRIAHRKPPPKGMQTDCKNQPVQTATDQKYALLFHITPFQLGNLGKFDVWTLSLPLMVTVHGSQDCDAQGVILWQRAFAKVNRSQAGEDVTAVSWNDLAHVLQHKFSLFTGAHRTLSDSDLQYLAEKLIVPQNVDNKLITFHRFAKQNLRDDVSFSFWEWFFLIMQLIKQKLLKFWDEGWLIGFISKHDASSRMLNAMQPTFLLRFSDTQTGAVSIGFVCEEDGMKGIEKVPFHLAPFTIKDLDQLSLAQRIASCPQLRDIRYLYPDIDKEEMLRYFDSEDRTKSESPTGYIQSEIVMVAKTGKIGSVFSGDSPSPMSNNGKLDWSPGEVIPHANSMDMDYNSDELVSMLSQSQLDSTNVESLLGAGFRPQLPSQPLQQVDLSFIDHTFANPYNMSHHPDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2F9</accession>
    <name>A0A914Y2F9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2F9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11981.t1">
        <property type="protein sequence ID" value="PSU_v2.g11981.t1"/>
        <property type="gene ID" value="PSU_v2.g11981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11981.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="21313" checksum="BD62489E4E092B95" modified="2023-02-22" version="1">MPPLDQDETQRRINEAKAKTAQARKAMKDASDLANYITKPFENGMKSVDKVLGYVETGIDIFNIVMVVVICGSIMLCIISPLIYIITTLITSISQCVAQCKSNKNQETDDYTKLNERILFIETNNGLKPAATGDKNQNDVTGEGGGGGHGKGASQRPSAKKGVQEGSGGATSGAAASGPGVSGGGNSTVKSTAKSVDAKEQQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y433</accession>
    <name>A0A914Y433_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y433"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13538.t1">
        <property type="protein sequence ID" value="PSU_v2.g13538.t1"/>
        <property type="gene ID" value="PSU_v2.g13538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13538.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11483" checksum="5E3276FF06FDE17D" modified="2023-02-22" version="1">MNTFSAKPAHPYSSYYDGGNEYSMYASGGGVSGQQQQQQQLRQGPPPELSGYMQAPRSSMNPNAAAFMPRQYDMPNVSRAPQQQQQQQQSYNPFGYNTSSVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y486</accession>
    <name>A0A914Y486_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g13589.t1">
        <property type="protein sequence ID" value="PSU_v2.g13589.t1"/>
        <property type="gene ID" value="PSU_v2.g13589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13589.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18940" checksum="98D1CA4263F1BB4A" modified="2023-02-22" version="1">MPFSKEEAEKVIKHFHDEAMKYIVAKDAKGLTSLYHPDAVLIHQGKWCVYGKDEILKKNEEVVKMSWDFDMEEVSTEGTGDGKFVIHKSNFKGKSDPSKTGWFAQIYMKGDDGKFLIVHDIFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKVIQIIRDGLQQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4E8</accession>
    <name>A0A914Y4E8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y4E8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14100.t1">
        <property type="protein sequence ID" value="PSU_v2.g14100.t1"/>
        <property type="gene ID" value="PSU_v2.g14100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14100.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17230" checksum="2D531F49FF999AA9" modified="2023-02-22" version="1">MPWILIRKRPAPNYLTHTSAPPKKKQQTIQKPQFRLISFCSRDLAEPTRLIFAYAGIDYEDINIENYKFFQPDLRPTDFPMLDYNGKLIRENDAIARMLARMYGLAGEGYFEQAQVDTIIAIMKELSNSIMGYFEGVLGFKVIDKVGGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Z8</accession>
    <name>A0A914Y4Z8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y4Z8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14512.t1">
        <property type="protein sequence ID" value="PSU_v2.g14512.t1"/>
        <property type="gene ID" value="PSU_v2.g14512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14512.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20606" checksum="0121AC6B45AC11A9" modified="2023-02-22" version="1">MAFYPPPSQKLQQEYPPPARRYQIREKIFSLGDNFKIKDEAGEPVFTVRSKIFSIGDKLVLEDMAGNALIKIRQELFHLMPRFTILSAQDDHELATVKKKLTLLRPKFSIDSIYGNYDLQGLDILAHSFMIVKDDRVVASVGKKFFSFTDSYGVEIVGDQDHAFIMSLVIVLDQVIYDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5D1</accession>
    <name>A0A914Y5D1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5D1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15411.t1">
        <property type="protein sequence ID" value="PSU_v2.g15411.t1"/>
        <property type="gene ID" value="PSU_v2.g15411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15411.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28809" checksum="7A7F5A4423725EB6" modified="2023-02-22" version="1">MKYYLSPACNLQLEEGHYINHNDQNVFLGQLNFDTTTASRRNTGYKATSILPEPYVDLLNKARCSGSKALNEELFRQPELNQRFLSKLSRFPKNVQKSAEKFEIFAYLHLVQDVIEADMPVVQNVTISINNKSTHGLDRNTISSIKNGKKLKSIIFINVPYQRNLSIKDKFATMVPVHLVRTKEVEAASKNPKLYKVYIAKVISPSQNQGSTTLIATLEAKIKKEFEGINANEKFSIFILQMLMQQIQFYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5H3</accession>
    <name>A0A914Y5H3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5H3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14687.t1">
        <property type="protein sequence ID" value="PSU_v2.g14687.t1"/>
        <property type="gene ID" value="PSU_v2.g14687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14687.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9572" checksum="8EC4FE110AB5A03F" modified="2023-02-22" version="1">MPKKKDAEKDDGEHLIIEPTQQSSHLEPIQENEELEVKLSRGNMIQKTFVCFDGKDWHEPQTAETEDFSFEIESGNTFSMLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5S6</accession>
    <name>A0A914Y5S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5S6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14795.t1">
        <property type="protein sequence ID" value="PSU_v2.g14795.t1"/>
        <property type="gene ID" value="PSU_v2.g14795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14795.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18419" checksum="805F5D971569B757" modified="2023-02-22" version="1">MDISIAVIHLKNSSTFNLKNICSPDKFDILLINGNQNGKIIKNLPKRRIKCQEDISGEAIKVAKELYGTSSIACHRAIPIPIHLDPNAYDFPTTSSTSISTASTSSLSYSTLFCIPMLDNDLKRIKLPKNFEYENLSNLLNDALNMSWKMETETRHFIERIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y663</accession>
    <name>A0A914Y663_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y663"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14257.t1">
        <property type="protein sequence ID" value="PSU_v2.g14257.t1"/>
        <property type="gene ID" value="PSU_v2.g14257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14257.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12837" checksum="46F6B6DC1242CC82" modified="2023-02-22" version="1">MNHATIPPPQMTNQFQLPSQPQQIQGLPPMNSSCISPMYPMAPQNPNMNFMQDPNFMQQMAMFMQQMQQMQLAQQQNGSMPMPGYQNGQANYGNGQTRMILDAKKDKNSLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7B3</accession>
    <name>A0A914Y7B3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7B3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15164.t1">
        <property type="protein sequence ID" value="PSU_v2.g15164.t1"/>
        <property type="gene ID" value="PSU_v2.g15164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055113">
        <property type="entry name" value="Med14_RM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055114">
        <property type="entry name" value="Med14_RM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22981">
        <property type="entry name" value="RM2_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22984">
        <property type="entry name" value="RM6_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM2" evidence="9">
        <location>
            <begin position="311"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM6" evidence="10">
        <location>
            <begin position="833"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15164.t1"/>
        </source>
    </evidence>
    <sequence length="869" mass="98878" checksum="52D3D6459FEE86D4" modified="2023-02-22" version="1">MDSAQNSVQHVVVSPGSEDSEFSQNLPQVPKEAGPQTISLAVLMDFAIQQSLHELTILSEMLLVKDQPERKKAIVQFAHATRLMFVKLLAVVKWLKQSKKFERLSGICYVLDQQAMCFIETADKLFELARVELQQARLPLFQVSTAIDVLTTGTYPRLPLIIKDAFVPEEKLTPFETRQTILLLNERLVFYLTKAAPTLPKRVSVFKIHNGTIIMRVTGEFQIRVTILPREKPEFVLLSVAILVKDHEIGGGMDLVHPLQLNTVHEVVQSRIAFSNEPFVEAFTFLHYFSLGLMLDVFECQARKLSAEIASNYVRVESYDPYEGTLVLRYWINDKIEQQQHQRNQPRINKLASNSIIYKMRIYIDREDRDAGLRIRHNPPSVVKLVDRIEAEREVSINSVISAVIEVRIRERVRQVLLQVPPHGPVFLAGDASPSIVYELLVHEKRSHVDEHLIVCVNAFFGHVVCQVHCLGQNEELRNLERELNGSCLLSEVIKIINRIRILLMISRYRNAAAVSQVKLVTEAQIPALVTLKNLPKDRLIMHFIREPNHFMIVSFEASNTIGVKVGFKMVSKTLENKLISLDVDPISIISETPIPSFYRSVFTGDQEVVRDEAIEYINGKLRTPVTEVVMEAMQNGDIDVLEPRLQSPWVGSEDQVKAVIAAIEDRLAFLKIAEELDKKGVKYDPVTIDPVVGGPVLKITDMSSLGSPDCEDFFDTVISASIRVDSRRNVYWPFEYTLKDQPLISNFYQNRALGKLKIVPANTLIAKMVNYENKRVAADHSIRCIVQEISTSIKDTIGESIASNVVDRVAIYSHLYGPVRRFSRVYHHYEKAIDVLAYTYHKLILAYGPRRSYTVHLSWKPQPTNAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7K6</accession>
    <name>A0A914Y7K6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CN hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7K6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15437.t1">
        <property type="protein sequence ID" value="PSU_v2.g15437.t1"/>
        <property type="gene ID" value="PSU_v2.g15437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15437.t1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36088" checksum="306161F25338847E" modified="2023-02-22" version="1">MSDPEIASLDSTLSDLTLDTSFGKIVKISIVQAGSIIYDTPKTLDKLERLTVEAASTGAELVLFPETFIGGYPKGVDFGVRMGLPILDGREEFKRYFDHAIDYNGIEADRISYVAEKCKIYLVVGVVEKEGTTLFSSVFFFGPDGTKLGKHRKLMPTAFERVVWGCGDGATLPVLDTSIGKVGAVICWENYMPMLRTCMYNKGVQIYLAPTVDDREVWVATMRTIALEGRCFVISACQYLTSAAFPRGHSAHTKEEKVLISGGSCAVNPFGEIILKPSYTSETIATIECDLSDIIAAKFDIDSVGHCSRPDIFQLVVNEKVQNSVTIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8D9</accession>
    <name>A0A914Y8D9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8D9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16466.t1">
        <property type="protein sequence ID" value="PSU_v2.g16466.t1"/>
        <property type="gene ID" value="PSU_v2.g16466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16466.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23824" checksum="885BCE74FF438693" modified="2023-02-22" version="1">MSEIASFASNIFAGLEYIHLRDMIHTDVKFGNIIIADNDTLKLIDFDRATPFVEAAQNSISNSRVRGTLEYEAPELSAGKNFDLKVDSWSVGVVLAECVLQTDYLFKRKSGENQNDSYRRTLDSSWQEILGECSLIKQDAKVKDSFFLLLQSLIVLDPSARLTSKDARTSDFLSKCTHLPIDPTKVTKYDPAVEKKFVINSQKIFDEELTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8G5</accession>
    <name>A0A914Y8G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8G5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15045.t1">
        <property type="protein sequence ID" value="PSU_v2.g15045.t1"/>
        <property type="gene ID" value="PSU_v2.g15045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15045.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22393" checksum="6886E1D72CE3630E" modified="2023-02-22" version="1">MRVPKPLSESQFESTIAEGRKIEESLATRATTEEETGNGYFVDKKVDNDQTTEGISKEVLNESTKAQMKAAGDEKKQIDTSFMSSEEQEKTQGIMKSASQAEIAAKLKESQETMRNLIEQHEIIDSDLSAVQKVRESPRSSQERSMKASSDEQKQIDTSLEAKSQDHETYAIRKSPSQTDIAAKVKAAGNEIRKIDTTLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y944</accession>
    <name>A0A914Y944_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y944"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15963.t1">
        <property type="protein sequence ID" value="PSU_v2.g15963.t1"/>
        <property type="gene ID" value="PSU_v2.g15963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15963.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10366" checksum="0ED95A85E64E1985" modified="2023-02-22" version="1">MSTIASPKNLPTNSELLEFIKKQDDVINELSKQLEKALLNQNNEVESSDENEISEVLSVNQKLLIEMKNKLKESVEIMEQLQVGHTTKINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9S6</accession>
    <name>A0A914Y9S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9S6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16034.t1">
        <property type="protein sequence ID" value="PSU_v2.g16034.t1"/>
        <property type="gene ID" value="PSU_v2.g16034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="128"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16034.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27773" checksum="FF84FC8A061B18C4" modified="2023-02-22" version="1">MEKLVVLPPLNEKALLKQLPNAKIGDVTKLMTNVKDIRGNVKEMMDIARECEKSLTPKQCTVLDAALDAIKECFHAGGQGLKKSFFEKSPELQSLKYALSLYTQTTEQLIKTFITTQKNQDLFSIEQPVGEVSVQVDLFSHPGTGEQKVTVKILAANDLRWQGSSFKPFVEVHLVGPHLADKKRKMATKSKNNDWAPKFNETFHFFLGNEGEPEHYELMFQVKDYCVFAQDRIVGVGGNIVTTCTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAK7</accession>
    <name>A0A914YAK7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YAK7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1724.t1">
        <property type="protein sequence ID" value="PSU_v2.g1724.t1"/>
        <property type="gene ID" value="PSU_v2.g1724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF217">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="6">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1724.t1"/>
        </source>
    </evidence>
    <sequence length="447" mass="52809" checksum="D6DA666D091CEE78" modified="2023-02-22" version="1">MEEEIPQVYLSEKDIIDQAPPEHAKILKAHFEEEDNIMRKKLEESSGGVQPQPKYIYISGKQMEIEQKCVFFQNVQLYDTLFVCEQCVEYFSDRDTLDRHYKCCIPNPLAGKEIYRDREKKFVIREADGFYDSSFSNRLCQIGRCFIGHKQLQYDIEPFSFYVLYEITDDNKYRFVGYFSKQKYQHTSCNLCCLLVLPCFQGKGYGRLLIDFSFLLSKTEHVPGGPEFPLSESADHIYYKYVLESIYEATFNVCYEELKKGTKIENVDLNLLLFQSLTGIAAKLIVKVLLEEKIMKVKKSKAKVEFKFDWEIILNHMEKQKSHPNRIFLHDEYLQWGPQELYVYEELLHFPEIEEERIRNSRGDNTMPEHEREKDIPGHHIFYHGDTNEQFDKRNKDLCASRSRIFVSKNGEKGAQAENIEIEFLKIQSIFTLKFEHCYSNHTVFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBE5</accession>
    <name>A0A914YBE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g166.t1">
        <property type="protein sequence ID" value="PSU_v2.g166.t1"/>
        <property type="gene ID" value="PSU_v2.g166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g166.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23567" checksum="7DEBAA8C955F2078" modified="2023-02-22" version="1">MENLEEEEEDLCTIPSLVLRLDSTRDSAGSKPFIKLAQLEGKAKRVFVVINTSPSTPKGTNSAIGRNTMMSLATNWGRRRRSAPELTETSVPTWVQNELNDAEYLSYSQFIPGPKPPIPISSENLQTEKQLHSEIEELKRQVQKQSTTFKGHETQMALLQKKLAELQALHSRAPNEAPPPYPQSAKDQRKRIIRNSFTPETQTKVCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCN0</accession>
    <name>A0A914YCN0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YCN0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17052.t1">
        <property type="protein sequence ID" value="PSU_v2.g17052.t1"/>
        <property type="gene ID" value="PSU_v2.g17052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="13">
        <location>
            <begin position="42"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="661"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="661"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17052.t1"/>
        </source>
    </evidence>
    <sequence length="717" mass="82277" checksum="0C58B5B8C56A1C1A" modified="2023-02-22" version="1">MTSSSIAPTSGRRKMPPWEPFSSKEAPQLKIYNSLTRRKDVFRPIDGNQVKLYICGPTVYDSAHMGHARAYLSFDIIRRVLSQYFNYDVNYVMNITDIDDKIIKRARQNFLFDEYQAKNKGDFYTVGRDVMKALEEFREKVEVETDPDKKKMLSDMLAKVNTVAMSIEKKLQEKSLSPSNMENETVDLLANAKDIISDSLDKRLGSTVNDQSIFAKLAKKFENEFMQDMNLLNVMPPHILTRVSEYVPEIIEYVEKIINNGYAYVTSDGSVYFDSTTFQANPKHFYAKLVPEAFNDTENEAKHMKEGEGELSISADRLQEKKSNSDFALWKTSKPGEPFWESPWGKGRPGWHIECSAMSTAICGNKLDIHAGGFDLKFPHHDNEIAQCEAYFDDSHWVNYFLHCGTLRIAGSKMSKSLKNFISIRLAIEQYSARQIRILFLMHSWNDALDYSPQTMEHACHFERVSKEFFLLVKDLLRKKKESDGNEASSFKKFDNDALQLFNKFYASKAVIHEAMCDSIDTRKVIETIRSILTESNTYITTTEATGTINADLLFTIAQYITRILKIFGVIPEGNDIGYPTDASGGCENKEELLMPYLSALATFRENVRNMARTAKNSDILKECDVIRDEVLPKLGVRLEDRANQTTLKLEDPEVLEKERLEKDQKELEKKQQKEAARLQAEANKKAKEEKKKQQELQKKKKQEEASKKQPPPSEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCU8</accession>
    <name>A0A914YCU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g18059.t1">
        <property type="protein sequence ID" value="PSU_v2.g18059.t1"/>
        <property type="gene ID" value="PSU_v2.g18059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12790">
        <property type="entry name" value="RasGAP_plexin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1182"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1380"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="15">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1562"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1562"/>
            <end position="1573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18059.t1"/>
        </source>
    </evidence>
    <sequence length="1862" mass="210713" checksum="6250E5F532682492" modified="2023-02-22" version="1">MPWQITNCDPNVYVKALAIDKIEHELIECSSVKRGVCRRRILGNISNIVEESNRKLVPSGPDGQVTAFVTMTCGSDICENKELNKQTLFLGITPTVREDTQYLVAGYDLKKGDQLNLLSNAFQGLYLSFTNAKSQAVNQIDYVMAFDYEKYVYFVIRQNHANSPSKLARICKDDPTFYSYSEIPLNCKTSTGEVLSYVQDAYVGNPQYYLAEEFHGSTIDNIQLIFAVFTDKFHHEFTDYSTSGICVFNMEDVSRQFTNAHKYCNAGKGIRGFDYHPSGIKDCTLNALTNFECGNEVNPHVFGSEFPVEATTFIHREKEFFTSIYVHGVKGTNVGFIGTSTGSLHKALIINSTSSKIFKTIQLTDDGSPILQDKKFVMSHASSINTPTLFLLSKYAIHKIKVDHCDKVDNCIDCVQQENPFCGWCLKSNTCSRDSECPEDVTLIDGFKQYITYQDSRSCPSILSISPNQQYIAVSRNLTISTQNIASSPSLECVFDIENVQRQRKKAENVTDGTFRCATPTFSSLVEAGVLDSQSSSVQSILSIVDRRATLISTNFTFFDCQQHKTCHECASSQFPCDWCIKNDKCVANSEDVCLGDLMVVSKTKEPASRRGPESCPLFDHRNHSNFYIGLGKNRQISVTAANLDDATMQHFKCNYTYGGGFVRTVNAVRRRNNIECLEFKFDNFEGSSILDPTLPIDLSILWAKEEKSRTARPGTELAHYRALDNPHKIKVIVYMCERLADNCGKCLTLSRDYECGWCEKTSKCTFRAACASDFLTILSPSVRCKNPQILDFWPRKGPLNGGTRLNITGVNLGLDASNVQVNVANQRCEVDRNEYRQAESIICTTGRVSTPQDGHVIVRINGGEKTADYAHAAVTEFRFINPELVKFRPVRGPINGGTDITISGHNLDSGRDAVVKIGTVNCRVRERTEHELICRTEKADYPGYKENIALTVDGAAFSLPSKISFEFKENPTVTRVERSASIVSGGILTEVYGKDFNLLQRPRMVAEYEDELQFGDICDVKSGGMMMICTTPPIAIKQHTRFSNEKPLLLRYGFSLDSREKAYTEYFGEDEEDDSNKLKVFPDPKILHFGKVQTAQAGADLVIKGENLTSAALVRDVRVRVGGTPCDVTALAEFTLTCQLSPEIDEVFADRDDLDVLVEIGNKVENVGIVSADAGIGASNYLILAASIAIISLFLLLIVFILYRRKNSSHNRQLRTLKHQMTSIEMKVAQECKEAFHELQTNLNAIAGSLPEGTSFIPFLSYHDYSARILFPHSFNNHPVLRELEVDQERAHQVESGLKQLYVLVQNRTFLLSFVRTIDENKYLLQKDRVYVGSLLMVILQERMDYCTEILKQLLKDLIKRNLEARFQPKILFRRAESVAERMLSVWFSFLMYRYLTGTAGEQLYQFYWATKQQTEKGPQDAISLEARYSLSEEKLLRSTVQCRELTVFVVSEGTGVICDTQVTVLDCDSITQVKEKCIDAKYRTIPFSGRPTVSDVDLEWRLPNGNRKLLLDLDQTSRHDNGYWKHNTLAHYKVDNKAMLALIPRQANSSSYNLSLLSDRSDKSSSSFNNSPTLTRPFGTHSSNGHSKDTMRVFHLVRQQAEHDTQEKMMSEIYLTRLLHMKGILQKFIENLFEVIFSTSNRSVRLPACVKYMFDFLDDQAREHNIVDEDVSHAWKSNALPLRFWVNLIKNPDFIFDIPKPTKIEGSLNVVAQTLMDACSTQELHLTKDSPSSKLLFANDIDKYKHIVHNFYEDVAKLPRIPEADMNSFLLQESQTHQRNFLVYSSALNELYVYVNSNRDMIFEELSKNEYALHEQLPERFQKMLETMDVVPDTNLINNGSLDNYNSKSRLMSNSNSRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEI0</accession>
    <name>A0A914YEI0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEI0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17162.t1">
        <property type="protein sequence ID" value="PSU_v2.g17162.t1"/>
        <property type="gene ID" value="PSU_v2.g17162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF13">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17162.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14360" checksum="D25922718DB6E803" modified="2023-02-22" version="1">MVNYTVCPGETRQLSDTYALFGQIVNGILTTLCVVLGSIGNIHSIKAVHFTNFDKNRGVVLAVSLLALALWDTILLWCAFFYYGMKSITQSPRSDMLNLMTPFIHAFSQIANTASVNFIHLIKITVTTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF03</accession>
    <name>A0A914YF03_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arp2/3 complex 41 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">p41-ARC</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YF03"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18854.t1">
        <property type="protein sequence ID" value="PSU_v2.g18854.t1"/>
        <property type="gene ID" value="PSU_v2.g18854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="11">
        <location>
            <begin position="106"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18854.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21787" checksum="827ADE39D93B6D70" modified="2023-02-22" version="1">MAAPVKNFKLDKGPIHSFAFNADRSQVAISVGNENVYILHLVGGKWIEKHVLAEHDMAVTSLDWAPKTNRIVTCSRDKNAYVWTFENNKWNACLVLAKLTFAATCVKWSPHENKFAVGSSQKLVSICHYEKENNWWIARQIKTEFKSTISCVSWHPENVLIAVGCYDYKARVFSAYVKDVSYDLLELFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF26</accession>
    <name>A0A914YF26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18882.t1">
        <property type="protein sequence ID" value="PSU_v2.g18882.t1"/>
        <property type="gene ID" value="PSU_v2.g18882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048170">
        <property type="term" value="P:positive regulation of long-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099577">
        <property type="term" value="P:regulation of translation at presynapse, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22426">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF7">
        <property type="entry name" value="FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="212"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18882.t1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54434" checksum="162D01FAC9051454" modified="2023-02-22" version="1">MEVEYRDKSNIYFPALVTQIGDKKVLLKSKDDAFPEGWYPFEDCRYVRNVETKPIRQIAAGDLIDALIKQSSSDKKAYQRAKVREIKGNFAVVENVEGSTISGVVNADECRFADQVEQLTESSLKKTTLALPEELINYASAVCQTITDNIPNTFAQFNESKKNIDIYALDTKTIRRISVASDMLLTQAKQKVSLIQKKDEVTKKFEQSSAATQAVIEFSVARDLMGLAIGSEGSNIKAAREVDGVTSIAIDESRETETHCFFKIFADNYDAAENARALLEYLTESVKVPSEMVGKIIGKNGKTIQDIVDKSGVIRVTIGEASPDEDNNMIDFFFTGTKESISLAEMLIDIHIKHVKEMESIRESIDETQRRLYPNSDNNGYFNRGYSRGRGNFPGGFNNRPNRFRDSRREQTNGDEHPRVQSPPENYHSTNEDDDAPVERKTNGFAQNGRGRGGRGGSNERFRGRGNRGGGRGRGSFAQQQQHNGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF81</accession>
    <name>A0A914YF81_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF81"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17416.t1">
        <property type="protein sequence ID" value="PSU_v2.g17416.t1"/>
        <property type="gene ID" value="PSU_v2.g17416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17416.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15993" checksum="5E5A06118C0168C0" modified="2023-02-22" version="1">MAQDNFAAFHIEKACAAIVDNSRYNKTYSNAISLLANVATDYMRKIATKAYALTEIAGDNETTVEHVLMANEAFGIKTSDLIQYIKSNKPFTTKALPVFPVLPPSSISRSKLPDDILDCLCNTFCSCLIDENNACCKTPSSAKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFI2</accession>
    <name>A0A914YFI2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prohibitin</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFI2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17517.t1">
        <property type="protein sequence ID" value="PSU_v2.g17517.t1"/>
        <property type="gene ID" value="PSU_v2.g17517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17517.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8794" checksum="457D2C87B96D51CC" modified="2023-02-22" version="1">MAAEAEATREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNSISAEKNSTIIFPFPIDLLSSFLHRPAPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFU0</accession>
    <name>A0A914YFU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17627.t1">
        <property type="protein sequence ID" value="PSU_v2.g17627.t1"/>
        <property type="gene ID" value="PSU_v2.g17627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17627.t1"/>
        </source>
    </evidence>
    <sequence length="573" mass="64524" checksum="A600DC27283773E7" modified="2023-02-22" version="1">MPRFPAAKKLKQEQMRENQRPKASENQRPKASQVSPNVMTTAPDSEEYCGTKSYSNPLSDAKKAHLRRLHETNDLKRQITAAKKNATVAKLTLISHKRTSSVFMNSSSDTESSINPDNQEIEPARLKHSSSINLIPVTPSRTPFISRQVLTVHTPSLASSLKSPENLSRSGFYKRLKATRERTKHELGAGYRITNSPERKVSVEEAAKYKVMKRLTDEQYQGLDSRHYPGLTAVRKYLKELSEKLEALEKDGLAQAIINHVNALEEFSRDVIRINIGIDKGSDTVKIVCFFTGDCKIKDEVTGLQGGSATCPCVYCMVPSAEWQATEFIPEWMLRSIDELLVAGEEVENAEESGTLKPTQLSNLKKTKKSVKARPMLKNIPITRFCPPIVHIGISAVSATVKYCKGKSTVIQDEINTLGLKTHQGTSDYTGPNCQRILKHFEENPEINGLGTDLLRSFAKIESYFVARDLKDEEIVELDEAIKTYFALIDDKYPDFLGKKTKLHILRHHVITFAIEFGSLGRFSEQSLESIHRIKNLCDTRIPGNSEAAKERKVQYFTKQQRLINHFTNEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFV8</accession>
    <name>A0A914YFV8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16233.t1">
        <property type="protein sequence ID" value="PSU_v2.g16233.t1"/>
        <property type="gene ID" value="PSU_v2.g16233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="4">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16233.t1"/>
        </source>
    </evidence>
    <sequence length="432" mass="47969" checksum="2410E92D96C77EB3" modified="2023-02-22" version="1">MGIILGVVLIVMCGISYYEELNTVKQISSFQSMIAIDCTVIRCARKLIVPASDLIIGDLVWIQNGDRIPADMRLIYCDDLQIETSWLSGEVEPLPYTDEPATEDKGVFESQNVVFSGCSVTSGHGLGLVIRIGNSTVLGNLVEITSKEKSHKAPLQIEHHRFVLFISISAIIVATVSFLLGLILTNFSHILSTFVNGFLIVLVAWVPQGLPVTLTAQLLIVARRLAKFGMYLKRLECADTLGITSILMVDKTGVLTQNDLRVTDLWTLENSVSAKTIIESHQKSLETSNSSENNPKYHISDGNCNLISGVDDIFGILITVMSICDKAIIENSHHSAKIALPRKTPSFRRKNLLSLNPEDLTKSTKSQIRQTQFSLKHKDLKEKSVIGKSLDVALVKFVENVTSVDKIRDDYDIVFEVPFSSQRRYHLVPQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHJ6</accession>
    <name>A0A914YHJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vps72/YL1 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHJ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18267.t1">
        <property type="protein sequence ID" value="PSU_v2.g18267.t1"/>
        <property type="gene ID" value="PSU_v2.g18267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 N-terminal" evidence="3">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18267.t1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33900" checksum="38FA23FD30525B24" modified="2023-02-22" version="1">MPRPAPRTRKRKIEEVEEQHRERELSEDIFDTPEKTNDESSNESSNDNDGSSSDEFEFESLAATRSRRSAAGTKMQELIEQQKEKDAKEMVQSEEVYKDFFEVENDEDFEADDGYLKSESEVDSDFDEDEADDDPEDVGEQQLRNERLTETSTNTDKARKKRERMMKELATSLLVEDNVVDDRTHARYIKEAKLVAKKNQEDLRRIELELEKQRNETLEFLRPKNRIERTDVIRTKEYFDENGERIRQIFIPNDSIHVWQPSEIWLSQQHLMSPKPSDFDKLSPEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHQ3</accession>
    <name>A0A914YHQ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHQ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18322.t1">
        <property type="protein sequence ID" value="PSU_v2.g18322.t1"/>
        <property type="gene ID" value="PSU_v2.g18322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="34"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18322.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18352" checksum="9BAA42397CFAD3E2" modified="2023-02-22" version="1">MVVNLKMLQIDAKISPFYTKWSLLEYIHSKWGLGANDDLLSADINAELQQLRGIYVRTTHKTINDVFRIRSVSIVGANQITFDVYGARTNVADYFRTRYNRDLNFPHFPCVIKGPDDKQEFFPLEVLMIEKGQKFPKTKMNSKQVFIILVSFSNTCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHS2</accession>
    <name>A0A914YHS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18343.t1">
        <property type="protein sequence ID" value="PSU_v2.g18343.t1"/>
        <property type="gene ID" value="PSU_v2.g18343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18343.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17314" checksum="B471B0AB5429369F" modified="2023-02-22" version="1">MTRRISRSDYLQSRNNVISQRKPKRIASSSAARLLPSQPPPPLPPPVTIEPYFEQVQEEKGGETSSNSSAPIIVQDQQNLPSGRAYHPSSSGATGWQASATIPPRTPSQNEFFRDQRFRFSTSPRRQVSNIRGGGALNAEGLQKHPSYLAYRRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ43</accession>
    <name>A0A914YJ43_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJ43"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19528.t1">
        <property type="protein sequence ID" value="PSU_v2.g19528.t1"/>
        <property type="gene ID" value="PSU_v2.g19528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19528.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10087" checksum="17AA67A74834527A" modified="2023-02-22" version="1">MIRISEEGPESEMKEYQQDEKALIKKLQQLHNGSYLLIPKNSADILILGLKNAGKSAMANALQKLEIVDGGKSIEEMSYNEMDCCDEIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJC3</accession>
    <name>A0A914YJC3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19412.t1">
        <property type="protein sequence ID" value="PSU_v2.g19412.t1"/>
        <property type="gene ID" value="PSU_v2.g19412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19412.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="11719" checksum="D0958E704C9BEF08" modified="2023-02-22" version="1">MASNHELAVTYAALILEDEGIAITGEKIQAILTAAGVQVEPFWPSLYAKALEGVNVKDLISNLSSGVGTGGGAPAAAASAPTGGAAAAAAPAKEEKKKEEAKEESEDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLB2</accession>
    <name>A0A914YLB2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase, mitochondrial</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Kynurenine aminotransferase 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Kynurenine aminotransferase IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Kynurenine--oxoglutarate transaminase 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Kynurenine--oxoglutarate transaminase IV</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YLB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18106.t1">
        <property type="protein sequence ID" value="PSU_v2.g18106.t1"/>
        <property type="gene ID" value="PSU_v2.g18106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000160">
        <property type="entry name" value="Similar to aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="49"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18106.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="23819" checksum="1786B4790838CC5F" modified="2023-02-22" version="1">MLSRQVSTLPKTVVAGVRQSSAWFGNVTMGPPDAILGVTEAFKRDNNPKKVNLGVGAYRDDQGKPFVLPSVRSAEEQIINGKMDKEYAGIIGLPEFTANAAKLAFGEDSPIIKAKRNATVQSISGTGALRIGSEFLSKWYPNNKVVYQPAPTWGNHVPIFKFAGVDVKNYRYYDKSTCGFDEKGCLDDIAKIPEKSVILLHACAHNPTGVDPTVSNNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLC7</accession>
    <name>A0A914YLC7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20352.t1">
        <property type="protein sequence ID" value="PSU_v2.g20352.t1"/>
        <property type="gene ID" value="PSU_v2.g20352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20352.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24542" checksum="E7E04A2818D4F680" modified="2023-02-22" version="1">MNIFRLAADSAHLVAIAILLAKIWMTRSCAGISGRSQILFLIVFISRYLDLFTNFVSLYNSVMKILFLASSIATVYLMFVKFRATYDKNHDVFRLELLIVPSFVLALLVNHEYSVMEIMWTFSIYLEAVAIMPQLFMLSRTGSAETITAHYLFALGSYRALYILNWVFRYYTESFLDPIAVVAGIVQTVLYADFFYLYVTRVIQQNRNIQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLD2</accession>
    <name>A0A914YLD2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLD2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1813.t1">
        <property type="protein sequence ID" value="PSU_v2.g1813.t1"/>
        <property type="gene ID" value="PSU_v2.g1813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="135"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="312"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="515"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1813.t1"/>
        </source>
    </evidence>
    <sequence length="625" mass="70263" checksum="32D6C638E3A6CA95" modified="2023-02-22" version="1">MSTRICVKGLPPRLYNENQLEKKFSGCGVITSIDLPALAKGKSNGIAFVGFKDKDAAEKAVKLFDKTFMGTTKIQVEYAKPLQKNVNKRPAPVEENTKNSKKAKKSHTQAATNNEGDRFEESANTDMIDKISKNGRLWLQNLAHCCTEEDLRELIGNKDVEEIRCLFNKQSGECNGNAYITFTNRDHAVEMYKVLDGTDFLGRKLKIFPCDDRKELSRSKKLQNLPFVPKSHVDHGTKSWNALFISGDVVAETFSKKVEMEKSKLLEGSKNLPAATALALAEMRIMQEIRQFLLDNNVNIYSFGTEQERSRKILIAKNLPPDFTEEDVQRTFKPFGGIKRIIFNPDIGLTAMIELNESGAKAAFDRINGAMLRGRPLKLEFAPISIFGKLPNRELMSCELIQKLMDMTKERAREGEQVALDVFSLMNATILVTFTNEVSNDFDFQKLFGKQKSKIIACGMLADQNPKCGFVFFDTIEDAQSAMEIKKSIINRDDILSIAIATEEIVLNGERSARKTLVVRNLPFTIQESEIMPLMKAVGEVKEIRLPEGVTGQKRGFGFVEFVDSGDVQKALNMFEGVHFAGRRMVIEISRMKETIKEGKAVEKKKQKITKKSLSSAMSSLRQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLH9</accession>
    <name>A0A914YLH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLH9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20406.t1">
        <property type="protein sequence ID" value="PSU_v2.g20406.t1"/>
        <property type="gene ID" value="PSU_v2.g20406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20406.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29545" checksum="7C8880E03D9BE096" modified="2023-02-22" version="1">MSVVCEQCNKSFTKRGLPSHIRQKHPKTDNNLDSKELDKSITESEPESSSSKSDIHWLDISTEDGTLLSSNATPVGLRKKGFYKLDKNSGNFVEADYDEGADWFRVSCKYCGQTCKRWDLRKHYVEAHLQANNDHFVLPNIFNVQTTSFSGTLSRSDAWPIDFSLAIQDDPLLKYDQITYSSYFSPDSNFKSSNELQKCFKYSVSMERIYSFNYVCPLCDEKISCVALNIMKLVVLVHLRVRHRDNGLLIKMCEEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN19</accession>
    <name>A0A914YN19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YN19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20994.t1">
        <property type="protein sequence ID" value="PSU_v2.g20994.t1"/>
        <property type="gene ID" value="PSU_v2.g20994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF7">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20994.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18710" checksum="74BC04C0EB6D7E3A" modified="2023-02-22" version="1">MEATKTTVNLTVCQDGVFSDHQTEYRLYGNMPISVIGIFANLLNIIVFADSEMRTLLMNHFLLALSLSDSFFLRDLYPTVVRYSYPLALTTQTCGVYLTVLVSFHRFLGVCHPFRTKRWVTRRPVQYAIISAVIFSIVINIPTWLELDIESCWSKEFNRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNC6</accession>
    <name>A0A914YNC6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Headcase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNC6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20466.t1">
        <property type="protein sequence ID" value="PSU_v2.g20466.t1"/>
        <property type="gene ID" value="PSU_v2.g20466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026066">
        <property type="entry name" value="Headcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054537">
        <property type="entry name" value="HECA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425">
        <property type="entry name" value="HEADCASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425:SF3">
        <property type="entry name" value="HEADCASE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15353">
        <property type="entry name" value="HECA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Headcase N-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20466.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30044" checksum="75CD8E95F3E613A6" modified="2023-02-22" version="1">MRFLFNFLQNLFEFPRQQENEKTKTPEVAHFKASQKLLNPNKVKNMRQERIRKEDRKEERRLKKEAAANSQKDDGIIRRADGIICCIPLVQCSRIGHPLPQTLEEGVKLNCTNPDCLHTKHLVHKECFRSLEQGLMTILQNQGSARGWTEGHRRRNLWGKKGLSLVQRSLRCPCGKGQMRRDEEAWKEREELVEPQKEKKDKPKKPKPKATQLPALQFAKKGIPPPIDLKKVHELDSHYLSTHSPQASDTFIEVKIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNH9</accession>
    <name>A0A914YNH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNH9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21161.t1">
        <property type="protein sequence ID" value="PSU_v2.g21161.t1"/>
        <property type="gene ID" value="PSU_v2.g21161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21161.t1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25522" checksum="6F037CCCB7F3FA42" modified="2023-02-22" version="1">MLTILATVWIIYFEDFEHLVQKDSLNVIETATSENFWNNVNRPELVENEEGLFVCPEEPCIGTFVNNSDLQSHLHIGIHIFSKGNQADYAMKRFKKRLEEMVSDQSTLSRDNVVHIALSQFSGAENVLAHYPRGWALVEEKKTVKRFTEDQKAFMTELYDRGVKNSKDKVRPEEAETMMKSAQKDGEPRFTVAEVLNKKQIKSFFGNIRQEKEGQNNTTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNM5</accession>
    <name>A0A914YNM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21016.t1">
        <property type="protein sequence ID" value="PSU_v2.g21016.t1"/>
        <property type="gene ID" value="PSU_v2.g21016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21016.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16144" checksum="AE14D36AD54345F8" modified="2023-02-22" version="1">MFQRQTHKKALSSCVVDAQTDVARHFSIGELRTLFELKTNIASDTHDKIKCKRCVNGLEVIEPPTNADTSSDLSNWFHSQTNPRKIPDSVLKNMWNCGVISFVFHQKSHEQTEEMKQKIKEEEEDAKDENYDPEKDCDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ22</accession>
    <name>A0A914YQ22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19465.t1">
        <property type="protein sequence ID" value="PSU_v2.g19465.t1"/>
        <property type="gene ID" value="PSU_v2.g19465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19465.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33132" checksum="07E75F48E4323B81" modified="2023-02-22" version="1">MGIVFRNDVELGVHKASEHGNASRNVNIDFQFSGRNLGSRNLRNGAQNERDYPTPVRQERLSVIPSDAAPPSLPSRIVPSAQAQQRQLVPSNVINTQDFPTLTSAPSSSSTASLPNWRQEVQSLRRPPQQSSQVRLQISSGEQFPTLGGGGTSRTAPAAETFPSLGGKSKNNNSAANSVWGKGKPIQLFTPNNPPPPKPKAPETPRRQFIPLPDPGPQEPETIDPLFRVEAAKKEKRKAAKKKSKTVPVSAFANREQPEDFVQPSKFDALAEDDEPKSAKKNKVNKINYALTSDNTVKIVIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQA3</accession>
    <name>A0A914YQA3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YQA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2121.t1">
        <property type="protein sequence ID" value="PSU_v2.g2121.t1"/>
        <property type="gene ID" value="PSU_v2.g2121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="11">
        <location>
            <begin position="114"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2121.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32682" checksum="3757DAF82495E27F" modified="2023-02-22" version="1">MPYDNKKESEYGFIYGVSGPLVTAENMSGAAMYELVRVGHSELVGEIIRLNGDYATIQVYEDTSAITIGDPVLRTGKPLSVELGPGIIGSFVDGIQRPIKDFKNMTASKYMNGQALGRDIKWEFVPSKDVQVNSHVVGGDIFGFVHETVLIKHRILLPPNACGTVSYIASAGSYTISETILELEFGESKKAYSMLQVWPIREPRPVNESLAANCPLISGHRVLDALFPCAQGGKVAIPAAFGWVKCYALIFVTPCAQYYTLLRQICQPQKQICLYTRKSKIEKNRCFALILSILNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQU0</accession>
    <name>A0A914YQU0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YQU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3151.t1">
        <property type="protein sequence ID" value="PSU_v2.g3151.t1"/>
        <property type="gene ID" value="PSU_v2.g3151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000016">
        <property type="entry name" value="Aerobic respiration control sensor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000032">
        <property type="entry name" value="Aerobic respiration control sensor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000025">
        <property type="entry name" value="Aerobic respiration control sensor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.970">
        <property type="entry name" value="His Kinase A (phosphoacceptor) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027460">
        <property type="entry name" value="ArcB_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040642">
        <property type="entry name" value="HKR_ArcB_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008302">
        <property type="entry name" value="PRK11091.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18415">
        <property type="entry name" value="HKR_ArcB_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037540966" description="histidine kinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="129"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="202"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="265"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3151.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="54469" checksum="2DBBED0D0DFEB9F4" modified="2023-02-22" version="1">MLLALALVVLAIVVQMAVTMVLHGQVESIDVIRSIFFGLLITPWAVYFLSVVVEQLEESRQRLSRLVQKLEEMRERDLSLNVQLKDNIAQLNQEIAVREKAEAELQETFGQLKIEIKEREETQIQLEQQSSFLRSFLDASPDLVFYRNEDKEFSGCNRAMELLTGKSEKQLVHLKPADVYSPEAAAKVIETDEKVFRHNVSLTYEQWLDYPDGRKACFEIRKVPYYDRVGKRHGLMGFGRDITERKRYQDALERASRDKTTFISTISHELRTPLNGIVGLSRILLDTELTAEQEKYLKTIHVSAVTLGNIFNDIIDMDKMERRKVQLDNQPVDFTSFLADLENLSALQAQQKGLRFNLEPTLPLPHQVITDGTRLRQILWNLISNAVKFTQQGQVTVRVRYDEGDMLHFEVEDSGIGIPQDELDKIFAMYYQVKDSHGGKPATGTGIGLAVSRRLAKIWAAILRLPANRAKVQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQU1</accession>
    <name>A0A914YQU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinogalactan endo-beta-1,4-galactanase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQU1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19740.t1">
        <property type="protein sequence ID" value="PSU_v2.g19740.t1"/>
        <property type="gene ID" value="PSU_v2.g19740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF17">
        <property type="entry name" value="GM01519P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19740.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9695" checksum="A68FB6234CA91A36" modified="2023-02-22" version="1">MELMARANETIHIGSYYWSLNYNDTGDGYSTFDPSVQPGLDFYNALIEAGKRGVKIEIAQNSEAGGYAETAYLEAAGLAQIFDTGLSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRJ8</accession>
    <name>A0A914YRJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2798.t1">
        <property type="protein sequence ID" value="PSU_v2.g2798.t1"/>
        <property type="gene ID" value="PSU_v2.g2798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2798.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13670" checksum="318D1680856BA794" modified="2023-02-22" version="1">MAADGTDDKLDGGSPITQTAPTYAEVENLCKALFEQTIGTEKYDHLEGVKWNKQLVESIAQGLVGMSRPFKYCVSCIIMEVGVASGVGLNVASTCFWDKQTDASYSIRCETKNVLAVCTIFAVNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSI9</accession>
    <name>A0A914YSI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myotubularin phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3129.t1">
        <property type="protein sequence ID" value="PSU_v2.g3129.t1"/>
        <property type="gene ID" value="PSU_v2.g3129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14507">
        <property type="entry name" value="PTP-MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF75">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="146"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="305"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="365"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3129.t1"/>
        </source>
    </evidence>
    <sequence length="761" mass="86264" checksum="DD960F740B1CE211" modified="2023-02-22" version="1">MQNGNSCINGMNNLTIAGGAIDSLPGEELEKYDDVLVCSDLYFSTYRIILVMKNRQGLAVIPLIMLDNVEAKDNVYLLLNCKDGRVIRMKANTAEAALTLYKRFTQISTVKRDLRKLFAYNFCTQVQKGSKPAWLKNGAGALTNLQVTKNSLLAEYKHLDFDEKLWRITDANAEFQICKTYPQYLIVPKNVTDEDLERTHIGRFFSRFPVASWRCKSSGGVLLRSAQPTISWLGIANDSDVKYVEAITSTISPIIEESGEKKVNKLLILDMRSYTAAWANRAKGGGFEGSDTYANSEIDFMSLPNIHNVRYSFSQLRNVLHSLDDTNYYQNLNATQWFQYLGLLLKTAIRCIEAVYAGKTVLVHCSDGWDRTAQIISLCKIMADPYYRTFEGFKYLVQREWIDFGHKFADRNGVFNEDPNERSPIFLQWLDCVHQLWQQNPKEFEFNQRYLMKLAQHCYSGMFGSFLFNSVFEAQQNGFIDGDATETTETIPPTDGSTSIVQIQNINAFELFNIWDYLDIHNRIFVNLCHKSKSTTLKCNPNIPFMRLWTEVYRCSEFESLTNNIVEESKDSVPPTIPSGNQMDPDRISNYSRSQSVSSLVSMNEIHGLSHSSGLHNAGVSGSPHFSNFPAYIYRCNQGISSLSNWKDFIDEDGLTKVPIELEDSVLPLVTQLMTEERTPPHSQSMTSSQYQHHPPPKRLSSLSSQNNHVEFNIGENHVKPSNGVSYPAKRMNGRTSETNSSPCADAENVPTRSGERISVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT16</accession>
    <name>A0A914YT16_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galaxin-like repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT16"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3140.t1">
        <property type="protein sequence ID" value="PSU_v2.g3140.t1"/>
        <property type="gene ID" value="PSU_v2.g3140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056601">
        <property type="entry name" value="Galaxin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24748">
        <property type="entry name" value="Galaxin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038069436" description="Galaxin-like repeats domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Galaxin-like repeats" evidence="2">
        <location>
            <begin position="49"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3140.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26567" checksum="9628A05A84743DF6" modified="2023-02-22" version="1">MSQYFIISYLQIFCIATVIFGQQLILRACCNGTENCREYNQPEEMFGVACCGNEPMNQFESICCENVTRSRRQGNTFIDKCCGNQTLAYDQTCCQGVVHNIPNGECCGSVAFSRTNAKALCCDGSLSLNAELGSACCGTIPFDGGIRESCCAGQVYLKDIYDGCCPVPDSIPQSYNPYNSKRQICCDQPILKIGNNKCCYLRNSNGTFAPKSFDYNTSCCAYPYIEITPKTNNACVSSTPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTX4</accession>
    <name>A0A914YTX4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTX4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3443.t1">
        <property type="protein sequence ID" value="PSU_v2.g3443.t1"/>
        <property type="gene ID" value="PSU_v2.g3443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052749">
        <property type="entry name" value="Alpha-tectorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160">
        <property type="entry name" value="ALPHA-TECTORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46160:SF9">
        <property type="entry name" value="PROTEIN PRY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="65"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="495"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="534"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3443.t1"/>
        </source>
    </evidence>
    <sequence length="783" mass="86402" checksum="2C32B233CD00D735" modified="2023-02-22" version="1">MYEKSCDCPDYTTGYHCENILSCDNDNKCGPNAECYVIHHKKICQCLPGYTGSPDTPEGCTLRTKKASLVTDPHYTTFDGTIFDYMGTCPYYVMKACDPTVDFSIISSSWLLPGETKYKTYTKDMTFKTQGHEFRVDNYLKYYVDGVVQTLASTNYWPDSLDPKIIATKPGDTVTITDTVTNAVITFSQAATSNPYALTVDVPLTPFFFGHNVMCGLFGSIDDNCFNDIAAANGTVYQTSNCTFPFGYVNATVASFADTWVTNSTVDNCIEGAVIGNITDNCNITVAQAQCGLIAQAIDGKGPFGACQAMGHDVVDKLYHDCTFDICHNGTQCGSLDIFAKLCQQSLPLANIDNWRTTTFCPYQCPPYSKYSMNTPTCQDSCSDPHFSNSNTCAYQEGCKCDVGYYFDSNSDVDGYNSVCIPLEECGCVDDKGNYHSPDSQWLDINCTVASKCVKGQLSSEVVECSISGKCIIDAGNPTCECNSGYTGSGFNCTDINECNDTTVCNADLHQGVCINLPGTYKCSCLAPFDGPQCTDYLPSRHCADIQIFHGLNESGTYNVSIGADYTLGLMNEQLNWTLVYCDMTSLDGGWTLMTHGNITAGKTYLQYINGFGDPTIQQVWLGLKNINAMTRDPTSLRVIIESCPHDSIPIQDCTYNSFHVTDNTNKYAVFINSTCQSNTDNSTIKGWITWDPTQLGPAFVNYDMDDVNGCSDMYYNSGWWYHNTSRSNKCGFANLNALHFNCQDDNSQFVGSYLTWHNFPVKDAHMYLRPSGYPNYDSHYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTZ3</accession>
    <name>A0A914YTZ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTZ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3462.t1">
        <property type="protein sequence ID" value="PSU_v2.g3462.t1"/>
        <property type="gene ID" value="PSU_v2.g3462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036848626" evidence="1">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3462.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21781" checksum="66C35BF638E1C726" modified="2023-02-22" version="1">MNCCFKILFAAFLLLNFIGAANFQENASKNVQFLDGKIYAKSIDEILSDGADVGIQQGNDVMIIKEGSINLTLTFNELEFEVCKDDCIGEAQICYESLNGLDDTNAVGSCFKFPSSCDFGLKNGKYNDQIYFADTLVYQDSGCLKSKMKYRLAEVKHNLQFKSCDPNINPTDKMIKLQFIYLSSWPIIVVSMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVY0</accession>
    <name>A0A914YVY0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Granulins domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the granulin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVY0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3810.t1">
        <property type="protein sequence ID" value="PSU_v2.g3810.t1"/>
        <property type="gene ID" value="PSU_v2.g3810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.160">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000118">
        <property type="entry name" value="Granulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039036">
        <property type="entry name" value="Granulin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037277">
        <property type="entry name" value="Granulin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274">
        <property type="entry name" value="GRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274:SF3">
        <property type="entry name" value="PROGRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00396">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00277">
        <property type="entry name" value="GRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57277">
        <property type="entry name" value="Granulin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111507" evidence="5">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3810.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10761" checksum="4E652425B6540F2D" modified="2023-02-22" version="1">MNKLFVSATVLLCFHFLFITLSAQDANHVCGESNYQCKAYETCCTFSDGNYGCCPYAYANCCKNVNACCQSGFNCQKNSTGCVRADTNDNPKDFDNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW04</accession>
    <name>A0A914YW04_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YW04"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3835.t1">
        <property type="protein sequence ID" value="PSU_v2.g3835.t1"/>
        <property type="gene ID" value="PSU_v2.g3835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="393"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3835.t1"/>
        </source>
    </evidence>
    <sequence length="807" mass="91072" checksum="2B521B7628AB7B1C" modified="2023-02-22" version="1">MESGFIMESSTSFEDFIECYPHDMVDDGADNSGHEFLVNSEEEDASINAIGKLVSDVIADNQFHTSSLEDSSCQEPQDISSKSIERLLNDVIAESQLVTQISALDDVERFNNSLFGLFTGVYRPATSTEIVTFTDCCVKKCTMFLSRFLIDHLRCALPLEKSAMQEFQFHLTKQFVINGQFNPVVASRDVCETIFASIYCISTSRLQTLLKEINDGQTQTLPHGNFGSSPKTAKFYERMAKIVVLLEEHAQDLPNKSGYVMSRGITQKDLMKLVSPDESKQLLPKHYLSGIKPALHWRASNDLTKCKYCSVFRCSLFHQKVINKEEVRQHRENHWANINADRLDYFVRKIFSLTHPQWLLSITHDGMSKHKSKVPHFLWNRAKFIIDADLAFCNLNGVIIHRKDKNGGDFVVDGYFNLSDVFPGGTNLVASQLIMSIVKTAPIPPVVAIQLDNCSVNKSYSMIATLGWLLIKQTTVKEFYLCFNEVGHTHIDVDALFGRYSQALSKKECPTPQALLDLFQKQQGVRQSTVDLKVYDFTTFLAPYQNNFGNLKNNHMFRIFIGSDNTPKVQIAHYIRSSKWLKSVPDAETWDYNVFKKLPPLNEEPPALLPSVDKLQKLQHTASAARQLLSEEEMKDYLSLVADIRAYVPTPFANILSLFSETVSETHNEAASNVLLDPHNKAIEKFMKEHKENISKIWNSLEVTNLEEAVYSNDTAELLAEESTVPEEEPTVSLGTINDNIELTPPPLTAPKKRGRKKNIPEERQSAQNAAASLPAEQLIVSLDEIESDATLPPPKKRGRPRKNPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWJ9</accession>
    <name>A0A914YWJ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWJ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4484.t1">
        <property type="protein sequence ID" value="PSU_v2.g4484.t1"/>
        <property type="gene ID" value="PSU_v2.g4484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4484.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11473" checksum="B4A671697A451E78" modified="2023-02-22" version="1">MLFWTSFKNFQPCYKVMNFEASKGLINPNETVNMSDLHNSFMALFRNWAELKTRFDKSAREFAGEKAWKELNNDIVQIKLKMTFWTSEIEKHKICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX80</accession>
    <name>A0A914YX80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4255.t1">
        <property type="protein sequence ID" value="PSU_v2.g4255.t1"/>
        <property type="gene ID" value="PSU_v2.g4255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4255.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20080" checksum="6BF80811D0E6F406" modified="2023-02-22" version="1">MSPFVSESRSAPETYSATIVPYNNVRIVDNTFLRQAFQNRQQNNEILGRVGAFSARIRHMPPPSPPQLTFAEPNNIGGILNGRVQDFFPREAIQERRSTPEIFVIEMAVEFRARSRRRSIVLQRIVDILRYEVGLERERYRANFYGYVAAEALSSIEDLFTLESKTPEYHRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXB0</accession>
    <name>A0A914YXB0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXB0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4288.t1">
        <property type="protein sequence ID" value="PSU_v2.g4288.t1"/>
        <property type="gene ID" value="PSU_v2.g4288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF35">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4288.t1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32765" checksum="B6C5E30BD46F0376" modified="2023-02-22" version="1">MDLFLVPQQIIIFVHEVSHDYLNTAGVVDKDFEEWLSSIQPYLNKSIVIVFSDHGNRYDSIRKTVIGRLESRLPFLSIKLPNWFLKKYPEMTENLKANSKVLTSHFDLHAFLVHILQANFSSSAPPNLPRGTSLFSSIPSNRSCFTAEIPSQFCPCFKEYEISPSNETTIFANLILSKIHNYFKEKNVLDKCAKMELDSIKTISLSLPPSKLSIDELQPTFKGDLYHYRIQFTVKSPSNAMFEGVVVKNKFTDEMNVLNDIERNNRYGNTSNCVDDALLKKLCYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXF2</accession>
    <name>A0A914YXF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2002 family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXF2"/>
    <dbReference type="SMR" id="A0A914YXF2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4784.t1">
        <property type="protein sequence ID" value="PSU_v2.g4784.t1"/>
        <property type="gene ID" value="PSU_v2.g4784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.40">
        <property type="entry name" value="Protein of unknown function DUF2002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018994">
        <property type="entry name" value="DUF2002"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007844">
        <property type="entry name" value="PRK10556.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007845">
        <property type="entry name" value="PRK10556.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007846">
        <property type="entry name" value="PRK10556.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09400">
        <property type="entry name" value="DUF2002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159894">
        <property type="entry name" value="YgaC/TfoX-N like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4784.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13066" checksum="D5BFDDB9E8AA6D2F" modified="2023-02-22" version="1">MYLRPDEVARVLEKVGFTVDVVTQKAYGYRRGENYVYVNREARMGRTALVIHPTLKERSSTLAEPASDIKTCDHYQQFPLYLAGERHEHYGIPHGFSSRVALERYLNGLFGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXS9</accession>
    <name>A0A914YXS9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CCR4-NOT transcription complex subunit 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXS9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4906.t1">
        <property type="protein sequence ID" value="PSU_v2.g4906.t1"/>
        <property type="gene ID" value="PSU_v2.g4906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="13">
        <location>
            <begin position="546"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="256"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4906.t1"/>
        </source>
    </evidence>
    <sequence length="676" mass="77125" checksum="14BB7D92AC4DF028" modified="2023-02-22" version="1">MAEKRKLLQEVDKTYKKVDEGIEIFEEIMTKMYEANSENQRDKFQDDLKREIKKLQRLRDLIKGWQFSSDIKDKDNLTKYRRLIETKMETFKDIERENKTKPHSKQGLSAEEKLDPREKEKAEAIEWFKTKIRQIQDEVDRTEVKMEAALSAGSGRKRKGKDESSKEKIEELKKHIEGLTYHITNLEVCMRLVTNDQKDPKEVMDVLQDALDNYVDALDPDSDMDPKECDPFGVYEELEIEEYIPQLAGVVTTSIDDEKDENSGTRSNNHSPFPEERPRNLSNEKPAAPVTTKLSSQQASEERTSISSPPPIATPPPSIPYNAVAAGVHLKSPAPVTAAAAPSSPAPTVSAATIVKPPAPAPPTPVSVPVPISPPSQTSIIRETPVTVPDTVRFQHPVPESPKPIAEPINNVAEPQIPMTPTRPPSLLTQNLPQSLMSPQPPPLSSLRSLNLERVIPNSPVLPTHSSRSNESQITQSSTQSITNAPPTMMEDSLIREFNPHSDANSDNRSSDIPSWLGVSPLGRRELSADEQMHIKRLEDAHRTMPHRFDSEPQRPAMPRIPYQGFPSYPQIQQPLFQTLDYYLRLSPETLLFIFYYMEGSKAQLLAAQALKKLSWRFHTKYLMWFQRHEEPKIITDDYEQGSYVYFDFERWAQRKKDAFMFEYRYLEDRDLTTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY18</accession>
    <name>A0A914YY18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YY18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5395.t1">
        <property type="protein sequence ID" value="PSU_v2.g5395.t1"/>
        <property type="gene ID" value="PSU_v2.g5395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056656">
        <property type="entry name" value="DUF7754"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24937">
        <property type="entry name" value="DUF7754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7754" evidence="1">
        <location>
            <begin position="209"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5395.t1"/>
        </source>
    </evidence>
    <sequence length="529" mass="61570" checksum="D54450ABAE65C4CE" modified="2023-02-22" version="1">MLCRTSKPDFVKPSLNSDQEEIHIYGEAREENIEWRFLAQVRILAAINEAHSSLRVVDYDIFEFSNRTKPLTLINRDHRLSHIRIEIRYVNQFYEKLPNFTEESRSGDILLNFSDGKPSLKVHSSLMALYSPNMAKNLEKFQTSEFLHSGKQAEIDMTECDREDFVEVLYQIYSQARPLWADFRRLSRGAVAYQILPVMERIIKHLIEFDMPIIQKIKEAIKLGVEDAIGELAFTAEKLGIWSYLIGTGFDPKAEFGDDIYHRLICPALIQAKRTPHFARYRFPYKLPYSLENPTEMEMPFMVPLKVSGKTFFVNKGILQLYNDSEMATGNNGERYFRINVELSKYLESKDLTIQQVIEAMLNYMNPQNHRIRIEFVRPVIMIANEHKMFKLVKEMEQFLVDEPPMTSELLLDQLVFAQRYNLKNVIGQTLLRIEVNFVNIAYNLIETEIFKKHISKDLQNKIMDRIVSGWGQSSWRLADCIPTKKLRRFIEGDCGGPTSNHDADLVTFNEINSHYAFGEPHAAKAEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZV8</accession>
    <name>A0A914YZV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DOMON domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3564.t1">
        <property type="protein sequence ID" value="PSU_v2.g3564.t1"/>
        <property type="gene ID" value="PSU_v2.g3564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36516:SF6">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36516">
        <property type="entry name" value="PROTEIN CBG04168-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037088207" evidence="1">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3564.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11862" checksum="7983481042961A9E" modified="2023-02-22" version="1">MNQFVIFMLAVIFAQTSAICRYTNGQYDLSWVVDHSDNVHFQLIYRNFPRLNAWTGVAFGQSMAGGLDAVIVKVINGRVSVSDEYVRGYSPISTRLFTRYPTSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z004</accession>
    <name>A0A914Z004_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z004"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3611.t1">
        <property type="protein sequence ID" value="PSU_v2.g3611.t1"/>
        <property type="gene ID" value="PSU_v2.g3611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3611.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18395" checksum="71893419937347F1" modified="2023-02-22" version="1">MLMLGFFVATVVDRWKNMFANIGFIDNVAIYVSTTIIGVEEELKIIRRNIIRYCCLTQVLVLRDIRFLMPHELKQMEDLESLHPKYWIPIKWVFNLLTDLKRRNKMEPEGYVNMLMGEVINYRNCLQNLCNYDYVPIPLVMILVVSGILLFITRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z084</accession>
    <name>A0A914Z084_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z084"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5289.t1">
        <property type="protein sequence ID" value="PSU_v2.g5289.t1"/>
        <property type="gene ID" value="PSU_v2.g5289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5289.t1"/>
        </source>
    </evidence>
    <sequence length="695" mass="77486" checksum="9DB7850942833501" modified="2023-02-22" version="1">MAVQEAGTRILHEHGNSKVPSPHRTQTLEDGNLQQQTSKEVKKSKDESTQRLIDDGNPIAPDNVPPRQSDTFFKELMVYIFGLIAIIAVWLIIADISHVSNQLKINDIYQLSWIPASLGVGIFIGSYLIIPLLLKVYALFIIQFFASFAVGVAVLQYNYLNFSSLLFAMVFLGIGFGVIERFLAFGLVFANLIVLNSTVLPMKNIANSDSHIRVKHDVGLHALNLSVYNPENQMTTQAYRPTKPSSAIGISENQDTKTAENAEKRKLAEQKKENMVAALNATADCLVNPNAENCTTTLTSTSTIESTTTSTSTSTPTTTFYTSTSTIVLKKDSIFDGTPLEPMVSSNPVDPIPRNRNRQNKIPAQNENSKQQKPNFTAPASKESTTPTFVASIIFIFFLFPFNFSAFICNHFWSKETVLNLSIASETFKQPSFVTRITSIILWFLSDFLTSGLFSLSPFIYASLFDKKIDEFSFYYGILIWGLVFFKRILLYIFSDFAVSKRCMQILIFSSLCCSIIFFVLTKSDLSFIIFLGIGITVSSLPILIALHQQATMNLSPYITSWRYMLWSSMGRIFGPLIMGKILANNSVHILTNLVFLIIIIMLVAFYYFTKNVTSTARHQQLQDLTMDISSPQNNVTNSPINNGAASSSSISSTIKTRSTQYGTKYSLIDAGDTDSLSNCLISDSEEDELLSYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0Y3</accession>
    <name>A0A914Z0Y3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein asunder</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell cycle regulator Mat89Bb</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Set apart in position or space protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13, IntS14 and IntS15. The core complex associates with protein phosphatase 2A subunits mts/PP2A and Pp2A-29B, to form the Integrator-PP2A (INTAC) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Integrator subunit 13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0Y3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3931.t1">
        <property type="protein sequence ID" value="PSU_v2.g3931.t1"/>
        <property type="gene ID" value="PSU_v2.g3931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019355">
        <property type="entry name" value="Cell_cycle_regulator_Mat89Bb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-95-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10221">
        <property type="entry name" value="Mat89Bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3931.t1"/>
        </source>
    </evidence>
    <sequence length="715" mass="81910" checksum="A2B6B6976DFB222C" modified="2023-02-22" version="1">MEFVRNSAHKTILILDRGPKFAKFSEIEFEVSYKDGTKQKKAGFAPKTLWNCSLDCTVEFHRIISDIFPSGTHLVRYIVSEVTSQFVFNRWHNVALNQEEFIQALYDLGCVEANPETDQSTCSILNAVGLAVDAFTQWSPHQKRADAFYKTKFNTKTQNAFHIVNSDRELEPICEDDNNDFYLLENSCTLIVITSFDDIDHEFQKLVETIEQNMNDKNRIIDDMKNDDETPLDSLKVFILNIVDDVDSVKDPVIPIDKIANERLKFRMFNINGKMMASYLHRVLLDAYDLVSTTIKGIPMKEDAQPGKSLDYDVEIFHPGCLHNQLRDEGLLKENSPIISKVATGGYNTVTLKWCNPVQKLRKDAYPIRESCAYSTPADLLSRPTICVVTFMKKGKCIWLELPETSISKTEANLAGKVVSHILTFDASRQGMALHAMSLGANLGALQYQINNISTEEGDNFSSGMLLIDEAFLTKLDEEPMVEIMSRMEAVYIDEPDPFMFEFPSEKFPEKEPDIFPVQKDNLTLMKIIFKDLVFSLGFSPDTFSCYHENREFADIRKLLKKKEVTTEKFKDVLTKTQKNIDKLLKRINKNPGHCYPKITIDACLFSINTLLDRLRNDFPHLYYQFFNDISKMFFKLADNRGLTKPFKLNRKRRPIYEDDGETSDEEVLEPSPKFYCISHPTDNEILKPTLAPASPMEDGEHIDDTIDDIDIVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z111</accession>
    <name>A0A914Z111_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z111"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3960.t1">
        <property type="protein sequence ID" value="PSU_v2.g3960.t1"/>
        <property type="gene ID" value="PSU_v2.g3960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3960.t1"/>
        </source>
    </evidence>
    <sequence length="640" mass="72372" checksum="C2F36B3A9F69CF54" modified="2023-02-22" version="1">MQKTAEKIDNVRTRQIAALKQILNLNQPVSSSLANEPVWKVLILDKYSQDIISPLITIKILRDNGVTLHFLVNSQRETLPDVPAVYLISPTDENIQYLCDDLKKSLYDQFYINMVYPISRPQLESIASAAVHSGTMNQLQRLTDQYLSFIALEDDLFMLRRYSTGSPFTFKAINDHTISEEEMEKLVDGIASGLFSVCATMGVVPIIKCPKDNAAEQVAIRLDQKIRDNLRDARNNLFTQEHIRGGQFSMHRPVLVIADRNIDLATMLHHTWTYQALIHDILDMDLNRVRMTDSNGKKKEYDMDQSDQLWKTYKGSPFPVVAEAIQNDLEEVKANEKSIKDLKSSMGFDNDTDEAVIVYSDTTSKISSAVGTLPELLRRKGFVELHTNVATTILSHIKQRKLDVLFENEEKILNGQTDVKIMDLLSNSIEPEDILRISLIHFLCSPNLSSSEKEELRAYLAQKEIDGAALRYIERLRSFSSMSRMSELHYGAGTKSESMFSNVLKNTSKLFMEGVKNLVPKKHNLPLTKLVDQMIDTRPSGVNMAGIPISSSASNEDDFRYFDPKLLHSSNKDAARSRGGQLAMDVIVFVIGGGNYVEYQNLQDYARSKGIQRMTYGCTEILTPKQFIEQLQQLGQHIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1C2</accession>
    <name>A0A914Z1C2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1C2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g592.t1">
        <property type="protein sequence ID" value="PSU_v2.g592.t1"/>
        <property type="gene ID" value="PSU_v2.g592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07087">
        <property type="entry name" value="ALDH_F3-13-14_CALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g592.t1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52266" checksum="9A760D2169A27352" modified="2023-02-22" version="1">MASYQVLVQNLRDKFNQGVLSSIESRKEQLQAFHKLVSENQDALCEAMWKDLHKPKIEGLTHETDFLLGEISETISNLKSWTSPTKVTRYILQAADAAYIQKDPLGVVLIIGAWNFPVRLLLGPIIGAIAAGNTVVVKPSELSVATSELIAELIPKYLSEDVIKVVQGGAKETTELLRERFDHIFYTGNPAVGKIVMRAAAEYLTPVTLELGGKNPVIIDKDADLQTVARRIVWGKCANAGQICVTGDYVLNLHPKRDELVKYLSEAIIEFYGANQKESPDYGRIINERHFDRVSELLETTKGKIAYGGEKDRDSKYIQPTVLVDVKLDDILLKDEIFGPILPIVDMETIEQAIDYIKSKEKPLALYMFSQNSSRIDKVVKNTSSGAVCINDLIMHMSLGTLPFGGVGNSGMGRYHGKFTFDTFTHEKSVLHRAAGLEKLLFMRYPPHNENKLTWTRRFIAKLKVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Y3</accession>
    <name>A0A914Z1Y3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Y3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6111.t1">
        <property type="protein sequence ID" value="PSU_v2.g6111.t1"/>
        <property type="gene ID" value="PSU_v2.g6111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019319">
        <property type="entry name" value="Plg-R(KT)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411:SF5">
        <property type="entry name" value="PROTEIN CBR-TAG-281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10166">
        <property type="entry name" value="DUF2368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6111.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17476" checksum="7D83C4A836ADCFCE" modified="2023-02-22" version="1">MLEWLFGNSKDSSPHINTEEILKELEKTRTERALALHEAMVERKNAYKLAEAKERFNWIASTGLLTSILSVVASFHHKNLMYSLPVVPISLYLAHQAHYAFGNKLDVIKQLSDQIILDPNAKLSTLPISLREIEARVEREKDISILECVDYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2X5</accession>
    <name>A0A914Z2X5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">26S proteasome non-ATPase regulatory subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2X5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4608.t1">
        <property type="protein sequence ID" value="PSU_v2.g4608.t1"/>
        <property type="gene ID" value="PSU_v2.g4608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000426">
        <property type="entry name" value="Proteasome 26S subunit, non-ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4608.t1"/>
        </source>
    </evidence>
    <sequence length="675" mass="73944" checksum="60E31E0B47CB162A" modified="2023-02-22" version="1">MTSFLLSQWKNQPGGPQNPVPFMLSLGNATTTPREKELIVKTFDDWGVLTSTWYEVADYLSTIEKLSDDSSFSERRRAALLSSKVAYCLGDYAGALQLVLGAEDLFSLSPRPAHPEYGQQDELYVNKIIEQAVDTYKIAKRDNTKIDQRLENLLDRIFNLNMESREYRQVVGLALDTRRLDQIERAVKASEDSTTLLSETVTKVLGSQLDRAFRSKVLDVLLRLFSELDEPDFVSMCQCLIKLEKPGDVAEILNRLVKNQDGELLAYQISFDLYENATQQFIQQIEKALIPETEKTGASTSESTTETSTSSTTETSSATTTTTATSSATATTSAVTSKSADDSSGSTSSSSDSAETVASGTMSSEVRDKLRSILSGEETIKHHMQFLIKNNHTDMLVLKHVKDSVRMACTHNGTVIANGLMHIGTTCDDFLRDNLEWISKATNWNKFNAVATLGLIHRGHESNALKVLDPYLPKGEPDQFGYKEGGSLYAYGLIHANHGSSNVIEYLQKQLASATTASVRHGACLGLGVAALGTHNDAVYAQLRETLYQDDAVVGEAAGTAMGLVMAASLDNTAFREMVQYISDTAHDKIQRGLRTGLSLLAYGRMEEVEPWVNELLEAKSNAVLRQTAVCMLAMAYAGSGKADVVRRLLAKVAADPNQDVKRFAVIAVGFVLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z305</accession>
    <name>A0A914Z305_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z305"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4637.t1">
        <property type="protein sequence ID" value="PSU_v2.g4637.t1"/>
        <property type="gene ID" value="PSU_v2.g4637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="519"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4637.t1"/>
        </source>
    </evidence>
    <sequence length="749" mass="83288" checksum="A6F4708B7DEF9A89" modified="2023-02-22" version="1">MVSAVQSIERQFQIPSKLSGFISSASDISYIPTVVFISYFGGKGNRAKWIGAGCVLIAFAHIMTATPNFIFPVKAPDLNLTKIEQQLNPSPNLLAENVTLKELFEFQPLKDRIPSKTREIVLQKFNGHSISERAIEDMKLKYTNHSNNSPYTVDDELINEAMYHFEEILHGNENDPKNVIAILRQFVVNRTKDHKNDLKTVRRAAIAHFAFCGKLVNDLRDTVDQLKCFRDGGNFGPLLIIFCALLGLGIGRTMPWSLGIPLIDDNVKRKSMPVYFAGISFIRILGPITGFLIGSFCNKLYFTAPAPPPAGLTPSDPTWIGAWWLGFLIIGFANIIPSLALFFFPTGDKSNKIVDSEVSTTKKRQSLKLFDRHKDENKKNNIGGREEDKTASDKFKTFATSYKEVVKSKVYMGSVIGRVMDVLAFKGYMFFLPKFLENHFGLPQYKVQQYMAMFGVFGFACGTLCGGLITRKFKLNGRNAAFFVFAISVANTAVFFSKSFLGCHSVVNGIGRDGVATNFNYTTSCNSECGCHSAKLFPVCDSAGNAFYSPCHAGCRHVSVQDLETQKLEFTNCDCAVNGIVKKELCHDDCKIMWKVFFGTIILGAFIAGTGVVPGMLILLRSVPPSTRSQSLGLQGFLVSLFGTLPSPVLWGALIDSACLVWDRSCTSSRGACAIYDPYILRMRMHIVYVCIRLVSCLTDLYVWYYAKDLNILEEEEEEDAKKTDIEKTEKDAAEVLEKDGAIPLQPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z382</accession>
    <name>A0A914Z382_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z382"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7157.t1">
        <property type="protein sequence ID" value="PSU_v2.g7157.t1"/>
        <property type="gene ID" value="PSU_v2.g7157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7157.t1"/>
        </source>
    </evidence>
    <sequence length="295" mass="30573" checksum="A19381E1354570EF" modified="2023-02-22" version="1">MGRFVARGGGGDRGGGFRGGRGVDRGGRGGGFGDRGGRGGGFRGGFGGDRGGFGGDRGGRGGGRGGGRGGFGDRGGRGSPRGGFGGRGSPRGRGSPRGGGRGGAGGMRGGRTVIVEPHRFEGAFIVKGKEDALATKNLVVGESVYGEKRVSVEEAENKIEYRVWNPFRSKLAAGMMAGLENIHIKPGAKVLYLGAASGTTVSHVSDMVGPEGLVYAVEFSHRSGRDLINVAKKRPNIIPIVEDARHPLKYRMLVGMVDVIFSDVAQPDQARIVAYNAQYFLKNGGHCVISIKANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z412</accession>
    <name>A0A914Z412_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z412"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7434.t1">
        <property type="protein sequence ID" value="PSU_v2.g7434.t1"/>
        <property type="gene ID" value="PSU_v2.g7434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7434.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="7581" checksum="AFE62003E672F7F0" modified="2023-02-22" version="1">MSTTTTTTQLTNDPSSSSSNSTTPRPSPTMPSTPLPSASATEGGASEEVPGAAPKADGEKVETAPNGMKKNANFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z453</accession>
    <name>A0A914Z453_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phlebovirus glycoprotein G2 fusion domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z453"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7128.t1">
        <property type="protein sequence ID" value="PSU_v2.g7128.t1"/>
        <property type="gene ID" value="PSU_v2.g7128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009878">
        <property type="entry name" value="Phlebovirus_G2_fusion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07245">
        <property type="entry name" value="Phlebovirus_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Phlebovirus glycoprotein G2 fusion" evidence="2">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7128.t1"/>
        </source>
    </evidence>
    <sequence length="324" mass="35384" checksum="80C5CA62A86011F5" modified="2023-02-22" version="1">MEVFQCVEWHIIAAVNVTISTQTTTTTRILTLSEGHSAEVGKVKIALIDANVENTIPSVNQQFIATEKSVALLDEIGVKAAELVKCESSIVAETFMNCTLLADACRCLPADGTVACSCLENKVLLKLLNKNALPLKVHDHWLEPTADKSVIARLSAKPRLQVSVQGLMLRTVIDQNSCKAEMHKLSGCSNCPEGAIASFTCTTDYGNAEAHVLCENSVSFPLKCSQRGYLQNINLFFDTVNVDLNCDVKCPSNTGKVNVHGILHQSVLENPWSTRTAAEVRPTTSFFMPILHALKDFWQQSYLIMIITLVVAGILAIIVLKIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4T6</accession>
    <name>A0A914Z4T6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4T6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5265.t1">
        <property type="protein sequence ID" value="PSU_v2.g5265.t1"/>
        <property type="gene ID" value="PSU_v2.g5265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5265.t1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15561" checksum="EAA5A8C6773B9ECB" modified="2023-02-22" version="1">MSNSERALLTSKYQLIENIKSLNLLFPQAIISFVIANTSITSSLILGEVYEPFRAPIFFQLYCVNVIVMSLYWTFQSTRFTFKLSTLRKSFLNQITDAPEIISLKATFVKTALGQRVKAQQTIDEHFLDLKNLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4U2</accession>
    <name>A0A914Z4U2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Choloylglycine hydrolase/NAAA C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acid ceramidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4U2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7375.t1">
        <property type="protein sequence ID" value="PSU_v2.g7375.t1"/>
        <property type="gene ID" value="PSU_v2.g7375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.60.10:FF:000006">
        <property type="entry name" value="N-acylethanolamine-hydrolyzing acid amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016699">
        <property type="entry name" value="Acid_ceramidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF3">
        <property type="entry name" value="ACID CERAMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017632">
        <property type="entry name" value="Acid_ceramidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="9">
        <location>
            <begin position="61"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR017632-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7375.t1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35370" checksum="1A0995F5FCA4EDD7" modified="2023-02-22" version="1">MGTIVTGDWLIPLIEHLMQFAHDELFPSKYAKEIDGIAESTGLSVADLAMMNIYYELSRFCTSIVAEASNGQVFHARNLDFGQLFVWDIEKKSWHLTEALKKITVNLNFVKNGKVIFKGTTFAGHLGIITGMKMDQFTLSMNAKVKPDISNVIKWLLGGYNGTDIHFAMWAEREVMEVANSYQEAKEYLSDIVQLAGCYYILGGKNHNEGVIIVRNETDVLDYVEMNTESGQWYVLQTNYDPDQKPLFIDDRRTPGHNCMKTLGQGNVSASGIYEVLSSKTTLNKTTVHTVIMSIATGLYETFIQNCPDPCWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6A1</accession>
    <name>A0A914Z6A1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM242 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z6A1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7855.t1">
        <property type="protein sequence ID" value="PSU_v2.g7855.t1"/>
        <property type="gene ID" value="PSU_v2.g7855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009792">
        <property type="entry name" value="TMEM242"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7855.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15074" checksum="DFF41C55FD082952" modified="2023-02-22" version="1">MNEPAVQRHEKEKSRWITAIKIACTATTATFFGLGIRAAFRQARPVEPTDLTRFKVMSGVGFASKALGIATLLTVSGYGLFVMGIVTFMDVNTPSQFGTKMKDVFGDRLRISKGNSIQTYESLSELFEAVGKKENDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6S7</accession>
    <name>A0A914Z6S7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6S7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5953.t1">
        <property type="protein sequence ID" value="PSU_v2.g5953.t1"/>
        <property type="gene ID" value="PSU_v2.g5953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021010">
        <property type="entry name" value="Cytosolic_motility_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578:SF3">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578">
        <property type="entry name" value="PROTEIN CBG21223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12150">
        <property type="entry name" value="MFP2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141739">
        <property type="entry name" value="MFPT repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5953.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14243" checksum="3BA9873C275BC342" modified="2023-02-22" version="1">MKVERLVAANFGWFNNEYKSNIGSIQVLIELSDQIRGFDYAWKSFKEAAIFGEKEWYPVHVEYHKGDISPCVLTVEGGKQLLGKVDVRNERATVAYGGKEHIFVGPTVHPFMVLCRKARPGHKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8B4</accession>
    <name>A0A914Z8B4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8B4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8572.t1">
        <property type="protein sequence ID" value="PSU_v2.g8572.t1"/>
        <property type="gene ID" value="PSU_v2.g8572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000080">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="312"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="410"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="522"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="626"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8572.t1"/>
        </source>
    </evidence>
    <sequence length="722" mass="81402" checksum="1F2C74DE58040941" modified="2023-02-22" version="1">MTAFRVLKDGTPIDETLIGVKYFPTKDTSRFSLRLRNIDPSDQGVYTIRLERGSTILQSDGKLIVKHLAPIEDEEDEKKREAETNGIEKKSKMPKKELSDDQPTFDSPPFFHYKLEDETVNINDRMILSVTNTTLPEPIVEWYKNGEKVYEDIKYAKRKDKGRYELIIASCEMNDDAEWQAIGTNKFGKCESSCRLTVLNPDKAEKPEFRHPLDNEIVYEKTQLKLEVTVVSTLPVKITWFKDDEKLSHTDEYRIMAVDTRHSLSILDCKRRHSGEYSVEAVNAIGKVSTNCKVTVKTGKPRGIDDEEALAPSIRMPLPATRELPENAEVKLVCAVTGIPTPEISWYKDDREVTFAELSYDNGLAQLFIPKAKTTHSGVYTVHAKNEHGTVRSVGMLYIEPSNELLNIAPKFKDTLINLSVMENSEIILECSASGRPPPQINWYHNGLKMIMTNRMLQYVDRRGTVRLSIMNAKPDDEGEFTCEAENAFGKDWTHCQVKVAATGLSNQRSRSPSPNRTAKPPMITRHLCDAKVHEGNRELLECEVDAFPEPSIEWLHDGNLVAESRTLRTYFDGRIAFLKIYQAHKDHQGIYECKIENKLGEATSSATITVESAMESKEEYIPNMPRFTKKLTNMQILREGENVELQCSVEGNPEPAIKWLLNGKAVHAGSGAESTKIGNLHCLKIANFTRDLSGTFTVIATNVYGDTHSSADILLPAIGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8E5</accession>
    <name>A0A914Z8E5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8E5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6524.t1">
        <property type="protein sequence ID" value="PSU_v2.g6524.t1"/>
        <property type="gene ID" value="PSU_v2.g6524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6524.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15357" checksum="99396D9A5CF60418" modified="2023-02-22" version="1">MGPTDRTTTFCGTPEFLAPEVLTETSYTRAIDFWGLGVLIFEMLVGEPPFSGEDEEEIFDSIVNDDVRYPRFLSIEAIAIMRRLMRKNPEKRIGSGEEDAAEVKRQRFFGLINHQFDALLRKDLKPNFIPTIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9J0</accession>
    <name>A0A914Z9J0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromodomain-helicase-DNA-binding protein 6-9 tri-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9J0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8990.t1">
        <property type="protein sequence ID" value="PSU_v2.g8990.t1"/>
        <property type="gene ID" value="PSU_v2.g8990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051493">
        <property type="entry name" value="CHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056342">
        <property type="entry name" value="HTH_CHD6-9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23078">
        <property type="entry name" value="HTH_CHD6-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromodomain-helicase-DNA-binding protein 6-9 tri-helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8990.t1"/>
        </source>
    </evidence>
    <sequence length="700" mass="76750" checksum="A71ECD8157B41A44" modified="2023-02-22" version="1">MLLAWGWGRWSLIKEKLENNLEEREIEHMARCFLLHCLREYRGDEKSRDYVWKLITPKGENVIKSDDKKDTNIFQQGWASNPEYNPPGFAIDHSFRRHHEIITEKWAEKCANPEISHTEINIKAPALGEFPPNTKWDSECDKSFLIGVYRHGNENNELIKADEKLCFIEKLEDGGFLSTTDINNRFKKLLLQHIRQTEMTLQSQTSIRNMIKQNSSQRGNWSVEEEDDFIRVLINYGVWDQTVNDKVNIKWTKFRERATSLAKKTDAQMMENLYCVLARCSKVQNSALGEADEARAEILSRIPAKKCTIILHRLTLMRKVHINGMAKDENYRRTHIRMIPLLSMPKGWTYELDERLFNVADTFGVNQLRKKLSTLSEFKTIELPSNKELWQRLYEIVLTLESGKYGGTVDHLQYDEESDDEREDELWVLALSNAGKQAAALPTATPESSSGGGGGGGGSSRRTQNKKKANAAAAAAAAAAATAVSVTPSSSSSSSKKDINSAHQNFVKQMDQAALQQQNYLMMHAAASLAGAAGSSTGGSGGSGGGSGKQTSNSAAATNDIVAQIAQLQAILQFTSSAGSGVTNASFNKAIEDAMNLSKKDSAHSTPTTSTSKTSNLNASTPSSSQKVSTTSSVSQSQKASTSTASASTPSTSAASAAAALAYPQMNCAEAEAFEKAALDQLGIGFAELMVLQSLDPSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9R5</accession>
    <name>A0A914Z9R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9R5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6993.t1">
        <property type="protein sequence ID" value="PSU_v2.g6993.t1"/>
        <property type="gene ID" value="PSU_v2.g6993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6993.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28333" checksum="9B251B2A5D33FF3F" modified="2023-02-22" version="1">MEPQKITQVRKVKIIYINDPGSDKPRPVYVTATSQPNTYQILSNPVIVTSASSDGQMRYATTISSTMPISTSTTTVSNYQSQQIPLSQIQPQTFFSRPPIVHHQQHLHQQQQQQFSTARRALIPQRRIFNPSQQPSQHIRFSKLPKLPAPFDFPEIKNFVSSKILPILSADYVDNFFMELNYSPPIIEKDFNVETLECPMEAPIQETQTSKKVANINVKNIPSTQTSKTLKKPNEQRKAPGIMRKATQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9S3</accession>
    <name>A0A914Z9S3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9S3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8550.t1">
        <property type="protein sequence ID" value="PSU_v2.g8550.t1"/>
        <property type="gene ID" value="PSU_v2.g8550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09331">
        <property type="entry name" value="LIM1_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09332">
        <property type="entry name" value="LIM2_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09333">
        <property type="entry name" value="LIM3_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09334">
        <property type="entry name" value="LIM4_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000011">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000017">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000094">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000141">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047944">
        <property type="entry name" value="LIMS1/2-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047946">
        <property type="entry name" value="PINCH-1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF0">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038003">
        <property type="entry name" value="PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6 7 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="242"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="302"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8550.t1"/>
        </source>
    </evidence>
    <sequence length="407" mass="47308" checksum="04C3859A168E51CF" modified="2023-02-22" version="1">MDHHHQHHQHQSPHQHQHHQQHQQQQQYSNNTADLDFYNDSHQHHQQQQNSGNNYVDSNACERCTEGFNVNEEIVNSGGRLWHAECFVCSQCFQPFPDGIFFEFEGRKYCEHDFHVLYAPCCGKCNEFIVGRVIKAMNASWHPDCFTCELCDKKLADIGFLRNLGRALCRECNEKEKAAGAGKYVCHKCHAIIEEGHIKYQGDSFHPYHFNCKRCGTELTVDSREIGGELYCLRCHDTMGIPICGACHRPIEERVITALGKQWHVEHFVCAVCEKPFLGNKHYEKAGLAYCELHFNQRYGNMCFRCSKPCGPESFSALQKTWCKKCFSCHLCDKKMDEKTKFYEFDMKPTCKRCYDRFPTELKKRISDNLKEKDVETLRRRSQSPARKPPPSSQSQPHPQSQPPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA57</accession>
    <name>A0A914ZA57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZA57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9207.t1">
        <property type="protein sequence ID" value="PSU_v2.g9207.t1"/>
        <property type="gene ID" value="PSU_v2.g9207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9207.t1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28473" checksum="7033BF267488826E" modified="2023-02-22" version="1">MGVHQVHTLGFNIAEATNFISQDYRKIARRRKACQCPGRLIKEQHLEKDQSLEKDQSLEEDQSLEEDQSLEEDQSLEEDQSLEEDQSLEEDQIPRNVFFSTIITRAACDSVTHLDGQVLPYKFDENLCARDLVKYFADKHALDDAYMFQVKCRSHDINGNPKVTTLVPTSFVNDGETYCIIISTFGECETETNPSQMVPPSPMTPMALSPHMTPRTSQQHRRIFGNFSSPSRIKYLITSTQPLTIPLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAD5</accession>
    <name>A0A914ZAD5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GMP reductase</fullName>
            <ecNumber evidence="1">1.7.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="1.7.1.7" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZAD5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9619.t1">
        <property type="protein sequence ID" value="PSU_v2.g9619.t1"/>
        <property type="gene ID" value="PSU_v2.g9619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9619.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22174" checksum="6793FD9A4B2F93DB" modified="2023-02-22" version="1">MPRIEMDKKLDFADVMLRPKRSTLKSRSEVVVTRDYDFLHSKGHYEGIPIVASNMDTVGTFDMAKTLAGHTLFTTIHKHYSVEEWEQFADSVNRDAKILDHIAISAGTSEADFTKLVQIVDKIPELKYICLDVANGYSEHFVHFIHRVREHFDKHTIFAGNVVTCEMVEELILAGADVVKVFKILFRGYILKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAN3</accession>
    <name>A0A914ZAN3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAN3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9380.t1">
        <property type="protein sequence ID" value="PSU_v2.g9380.t1"/>
        <property type="gene ID" value="PSU_v2.g9380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9380.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13509" checksum="FBB10595682BC6B8" modified="2023-02-22" version="1">MTSWNSDIEQHKSSNSVLKYFAKAAAPSTSNAGASSAPSTSNVATSSAPSTSTLNTEKPKPAQEACIKKIEDLKNEYEYITKKNFKTIEDHEKLKFLKKSLKQEESNLKNLKVCHNWPIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAQ7</accession>
    <name>A0A914ZAQ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAQ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9404.t1">
        <property type="protein sequence ID" value="PSU_v2.g9404.t1"/>
        <property type="gene ID" value="PSU_v2.g9404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9404.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24845" checksum="AC898E4D12450ED9" modified="2023-02-22" version="1">MLCLNNDVLFEVAKNLIENDVQENVYLFGLSGRQPWHALRRAFASVKIVELYDKYYKIGWDRKLAKFEYTGDKPHAKSLLNCIGNNVKELRIDSNNVIYSPILRTIMTAKKITSLRAYRKCSAKEITHFILSCSSSLEILKIAPSLMTKELQNQFTIDTLTLLDMDGLDFFPYCCKISTLVIENIQGYSLWRAFYIRYKFSFDSGYSISHIYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB64</accession>
    <name>A0A914ZB64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9156.t1">
        <property type="protein sequence ID" value="PSU_v2.g9156.t1"/>
        <property type="gene ID" value="PSU_v2.g9156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037734952" evidence="1">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9156.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22948" checksum="F74630F8A2FD041D" modified="2023-02-22" version="1">MFWPLLCVTILLLSFKTAKSCDNGTIEFDGNLEKCATEPLHFLDDFNCAFFWHDNCGGRRLGICDENPDFSKQNFEYDASAVVVRDGCIATACHGYNFTDGCATFGPGYHNFWFSKQFTSGNLEEGIPGPDSFNDRVKSAKCHCIIPTTSTTVTPTVTPTVPEKLKTFEISNANDNNNKDVYFLDILLIPKKASVKPKKIFSLITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC52</accession>
    <name>A0A914ZC52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9497.t1">
        <property type="protein sequence ID" value="PSU_v2.g9497.t1"/>
        <property type="gene ID" value="PSU_v2.g9497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9497.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28912" checksum="4FEE9A73E0BDEEE2" modified="2023-02-22" version="1">MEEFSTSIGLPTLSATTPFATINFGLPASMLQLYHTNTPVNTNELTIYHPEGNTPKGWQTIHPTMNPFVPHPLPDPPKDLLELQNDRSNISMTAFPGSVTSQMDIDMIEAEQPLPRPIPTRPFNNYCRSPSSEQSDHSESNNNRKLSQSSSPPKNNNNNKKKPRNSSGGGGSDDRAERRKKGNTESQARSREHNKIIKGLYELNDKLIDAINQEYLKNGNHNDPLINKLLTEYERLPKKQRPYKKRTPSSSIINEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC64</accession>
    <name>A0A914ZC64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">E1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZC64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7838.t1">
        <property type="protein sequence ID" value="PSU_v2.g7838.t1"/>
        <property type="gene ID" value="PSU_v2.g7838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.570.10">
        <property type="entry name" value="Amyloidogenic glycoprotein, heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008154">
        <property type="entry name" value="Amyloid_glyco_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015849">
        <property type="entry name" value="Amyloid_glyco_heparin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036454">
        <property type="entry name" value="Amyloid_glyco_heparin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02177">
        <property type="entry name" value="APP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56491">
        <property type="entry name" value="A heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51869">
        <property type="entry name" value="APP_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037248745" evidence="2">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="E1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7838.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9492" checksum="06FF9D8CD3090D76" modified="2023-02-22" version="1">MAAARPLLTLFVIGLAFANSAHIEGVSANVDSDSPRSHQPFIPLVAFNCGYRNQYMKENGEWHSDDSKLATCLQGKYDILKYCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCL6</accession>
    <name>A0A914ZCL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZCL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9449.t1">
        <property type="protein sequence ID" value="PSU_v2.g9449.t1"/>
        <property type="gene ID" value="PSU_v2.g9449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9449.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29463" checksum="5BF2E6F08BBCD35F" modified="2023-02-22" version="1">MDISVIATYAGIGVQFFTSACGIIGVICSNRDLLRIYWVFMIPLIAFDFISAIIWAFKFNFIHRDFNSYFNNVIADELQHNRNLTGFCTVFKDVHDELFCCPKLSIRNACRGDWEQCRISNKQDCIIPLLHWLHSEIDPLAGILYFLLTPLKMMVVFVLREDMMELLTEIIYRGDPSLYRKHWMSYDSDDEESMINSSSQSSSGHSSSRHQDKGSEKSLLQIKALAKEPRIIMNPQARDIKRPKIIKDTSSSSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDA7</accession>
    <name>A0A914ZDA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDA7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9654.t1">
        <property type="protein sequence ID" value="PSU_v2.g9654.t1"/>
        <property type="gene ID" value="PSU_v2.g9654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9654.t1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33428" checksum="AD6B83F7E2271DE5" modified="2023-02-22" version="1">MIEKYRSEIERISKIPLPVSQFWIDTILYEYDFGTKETALNILKRALPISAQCSINAEIQNFPLFSTKFFKILKNTDQLQNTTLSEKEDVENLKAPRKSPISCFYPKTEIEALKKSQKFSFHKTIIFYITQNIKCNHRILQKLFNSCKYFFAVQPTPICYRLVLGWREASKYIEQSLFLNIKDLDFPGLDNLYITTTLDILTYGSHRNILSNAIPRFYKCEAKYGHIEEQHITMDEFKFLYNGLPPIGNMIPWDVKIIHKGKTLDAEDHLWNINFLKDNIVENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEE0</accession>
    <name>A0A914ZEE0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZEE0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8637.t1">
        <property type="protein sequence ID" value="PSU_v2.g8637.t1"/>
        <property type="gene ID" value="PSU_v2.g8637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8637.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16337" checksum="4D0EB483BCDE752E" modified="2023-02-22" version="1">MDRERNRLDSCSNADDDDDEICLNDASSSTATTTKQQLTNKIPIVKIFAPHSHECCSSSSSGNQYHEKSEHLFKKLLIACCDSCERRASLIPGSSSNDELDTEDENHTECDESEHEGEGDEDEAENTFECMEENKAEMHDAAKFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHJ7</accession>
    <name>A0A914ZHJ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZHJ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9775.t1">
        <property type="protein sequence ID" value="PSU_v2.g9775.t1"/>
        <property type="gene ID" value="PSU_v2.g9775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="375"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9775.t1"/>
        </source>
    </evidence>
    <sequence length="536" mass="62648" checksum="E22F73A3831E19A5" modified="2023-02-22" version="1">MEYSDAKNGQIEKYVSKSFGSTANLLIIVDKESKKDVNQFCKIINQVLCKHSEKKIVIIGNENSPTASALKTAPTQVPYDIYLDKCNFNDLTPNSQLNIQKNTTVTFQGSNASLCDLIDSNDSASELIDSETLLKMVMGEKIIIGDPIKNFTDTEEQYYHQRKFRLIEIDCKVFKETLLKQNHLFFIEGIKVLKYLKKNGIKKSEIKDYKNSSADCRFIIVKADDSKLQYGSVCENHPNSYIYWLKLVNKRLIWFHSYIPPSACLTQEFVKHIKQNDTYVDESFFYEYVKQNNIVIITDIAGMGKTTVLKSFSKTLDDTTYWKIRINLNQYTDTLMEIKKYIKKHNITVETLFKEISELQLNFAFFDGKDYGKLVLKSLINNQKPDVGKLTFEDRIFNHFFTKNKMLLMFDGFDEINPDYGDEVMALLQKLKKDEKNRIWITSRTNFKEMLENKLNTFAYDLKPFDEEDQEIFLTKFWLNNWKMEKGNDMPNQDRLSLYITELLEEASEIIGDIIGIPLQTKIKTWKYIFALRTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSH4</accession>
    <name>A0A914XSH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSH4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10929.t1">
        <property type="protein sequence ID" value="PSU_v2.g10929.t1"/>
        <property type="gene ID" value="PSU_v2.g10929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10929.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23159" checksum="E8B7A140ACF3A604" modified="2023-02-22" version="1">MANLEKLCDVLGVETPEASQISEKSANSPKRRSTEKPKTKKKKRENNLVGYSDSEYDSIDELSSDGLELLETGDTPIRPSKQTAKKLQKRNRILESSSEDEAKEVPIKVEKIRRKRTATTTSTKNVPNKKGKKNAPITKGLSLRKARQQTITPTPVDFDDPVVEFPESDKENDVAPKKWTAKEKDRFLVYFLIFFFDLFTVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUV6</accession>
    <name>A0A914XUV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUV6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11723.t1">
        <property type="protein sequence ID" value="PSU_v2.g11723.t1"/>
        <property type="gene ID" value="PSU_v2.g11723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11723.t1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14278" checksum="7E88ACB948671B9B" modified="2023-02-22" version="1">MSYPYRQKSIETIQRQKKYYPLEYPRSYSAAPKPYPDPPYYSREPPKDQDSCRQFSKYAIFAFNILFLLVGSATLALGTWLRTDSRFREFLSERYKQVVEEAFWQAPTLFTFSYILIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVN8</accession>
    <name>A0A914XVN8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVN8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11298.t1">
        <property type="protein sequence ID" value="PSU_v2.g11298.t1"/>
        <property type="gene ID" value="PSU_v2.g11298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11298.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19445" checksum="4649BA036070754B" modified="2023-02-22" version="1">MADFVGNFYGFTQRNKFNVKYQSRIDAKVYQFSCVRVTLKDVGTFRCTACKSAYDKNNNESVYTTKGKVNFDDGTVMFFNDPDAHPHCCERIESNVVKGKKIRSEVKKKIRETGKTGGECLKLINEEVLAQDENGDADDVMKKRISRCHYFNLQLPLHEKFVRLFKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWC8</accession>
    <name>A0A914XWC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10084.t1">
        <property type="protein sequence ID" value="PSU_v2.g10084.t1"/>
        <property type="gene ID" value="PSU_v2.g10084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10084.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8582" checksum="3039144BA09C2229" modified="2023-02-22" version="1">MLDYCEPVNRRKLDFKLQKLSGNNKRRQLDHLKSHYDPATGSYDQSHGESPKSAAKLSTPKKENRILDSILRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWM7</accession>
    <name>A0A914XWM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4025 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12346.t1">
        <property type="protein sequence ID" value="PSU_v2.g12346.t1"/>
        <property type="gene ID" value="PSU_v2.g12346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12346.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8157" checksum="6A888DBAAF3724EA" modified="2023-02-22" version="1">MSNQYSAKDVYEQGKGDDYQISNNYEGDLDNAIATPINQDTANDDVETKEGELTSTGQQPDFITVTEYVDQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWV7</accession>
    <name>A0A914XWV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-conjugating enzyme E2</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11452.t1">
        <property type="protein sequence ID" value="PSU_v2.g11452.t1"/>
        <property type="gene ID" value="PSU_v2.g11452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11452.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7742" checksum="4A9B2D9CD679268C" modified="2023-02-22" version="1">MELLTKQGWSSAYSVESLILQISATLVKGKARIAFDGKGNSYSLSRAQQSFKSLVHIHSKSGWFTPPKADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXC7</accession>
    <name>A0A914XXC7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXC7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11864.t1">
        <property type="protein sequence ID" value="PSU_v2.g11864.t1"/>
        <property type="gene ID" value="PSU_v2.g11864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11864.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13315" checksum="C73726C168D2D742" modified="2023-02-22" version="1">MSHKKLKKNSYFKHEYERVNSDPTLNDSDPLTMHSSDDGVKQTLLTPGSNRAAFDPAEIEETVQSTSRRDSDYDLEQYEMDDHIGDIPHSFNRRHRRYFTFLFFKLKISLKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXU9</accession>
    <name>A0A914XXU9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXU9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12773.t1">
        <property type="protein sequence ID" value="PSU_v2.g12773.t1"/>
        <property type="gene ID" value="PSU_v2.g12773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12773.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39391" checksum="31906C8FE470FE03" modified="2023-02-22" version="1">MPLTPTKKRKIPAKNSVESNLPILQEGPNIESFFANEIMINVFKFLPRNVLDKCRLVNRRWNDIIDIHGYNFARRSIDKLNIYSEFCQNFITFGGFSLASRSEIQYVLDGNDHVGVPGIVHILKNSNIKCLVIGPIDLCDSNAEQILSVLQGADTHIMEIQMRRVGLGNITVKLFHKFCEKINTKRYAFSEMRQAQNEYFGNEFFNKMIFKESSYIYIKGLVANALAVPVAVDDETLLDFIFGVNIKSVERKVACLELPSISSQFVTKILNRFANEADITHMVTEATLLLCPPQTVLRSYQSLNIRLGYVNYASYNVTENKELQVEIIKQKGYFVNVFLSLGEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0A3</accession>
    <name>A0A914Y0A3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0A3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12893.t1">
        <property type="protein sequence ID" value="PSU_v2.g12893.t1"/>
        <property type="gene ID" value="PSU_v2.g12893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12893.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12257" checksum="63F2FE8CB93324AD" modified="2023-02-22" version="1">MSLTGSGRFRSVYVDDFDRHSSFSSSGKSGVFNPNGFVNGNNINGNDNNGIISYEPGSGAEYMYSKGWHTRDPYGKPLPTINRSIRNNNNNGGGGVRFDSTKSDDLLARENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0N2</accession>
    <name>A0A914Y0N2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0N2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12343.t1">
        <property type="protein sequence ID" value="PSU_v2.g12343.t1"/>
        <property type="gene ID" value="PSU_v2.g12343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12343.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10094" checksum="ACFCAA183A840DB4" modified="2023-02-22" version="1">MTADTPPDKNTTTENDELGEIKTKLGFKERPGFEPILVEIAYRKGPKLGLIIRNFENCVMISRLDAGSLCAEKLVVSLLVLIIWRGFSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y101</accession>
    <name>A0A914Y101_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">purine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:27738"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27750"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y101"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11516.t1">
        <property type="protein sequence ID" value="PSU_v2.g11516.t1"/>
        <property type="gene ID" value="PSU_v2.g11516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="11">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11516.t1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10334" checksum="C9336AA96902C91B" modified="2023-02-22" version="1">MTGGPNYETAAEIRFLHAIGGNAVGSSTCHEVAVARQCGIKVFGFSLITNKANSEDEDEEEKIDHEKVFDAAKNAEKHACAFVEEFVKQLKFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y119</accession>
    <name>A0A914Y119_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y119"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12480.t1">
        <property type="protein sequence ID" value="PSU_v2.g12480.t1"/>
        <property type="gene ID" value="PSU_v2.g12480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037777925" evidence="5">
        <location>
            <begin position="18"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12480.t1"/>
        </source>
    </evidence>
    <sequence length="571" mass="64153" checksum="CC2652AA0E76348A" modified="2023-02-22" version="1">MKQILIIALSVVAFAAGQCPTTIKAPCTCSTTRFEPISIHCDRADSIESVIKALANPPQFIDSLTISNTPIEQISEGIFTGLSIRRLILQNNGLQDIKKGAFSGTLLNSLRELEIRSNGFEVIPENGITELRSLEALVLSDNNIEKIDDYTFLHYQSRTHLKKLDLSANKISQLPAQSLLGLENLQTLILDKNIFSSVPTEALKNVQTLEDLSLSVNKIKVIEPNALPLPSLKSLSLEIEILRPEVFQDTPGLLYLYLSNNRFSIVDPKSFYYVKQLKVLAMSHNVALKLIPFNAFQYIPSLIRLEMTDCSIGTLEEGAFHKTPKIQVISLARNKLKRVGVSMFSTLPYVQAIDLKQNQITTIDDYSFSRLKMLQKLDLSGNKLESVYPNTFFDTFEKSMESVLKVLYLYDNPWRCDHQIVWLAKWLRQTLDLQITAPGNLPARCTQPPELSGIDLRNAEPMIHVTLTTTTKKAVKPGYPMRAINTNSIEDWSSHTTYNPYERNEQAPVATNPLSTIITIIVIILAILCIVVVIVLIVNFLIKQKIKQVNFTVIQAVNVVITVLIHQMHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y129</accession>
    <name>A0A914Y129_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y129"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12925.t1">
        <property type="protein sequence ID" value="PSU_v2.g12925.t1"/>
        <property type="gene ID" value="PSU_v2.g12925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2130">
        <property type="entry name" value="DEAH helicase family, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042035">
        <property type="entry name" value="DEAH_win-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="272"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="514"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12925.t1"/>
        </source>
    </evidence>
    <sequence length="766" mass="87025" checksum="A7FD9F8E976CD19A" modified="2023-02-22" version="1">MPNIPKPSKKRKASKSVQDDSIKIETSKENENEYSTVGDATELALPSKKKKRKETSEPLQPPEKRENKKKKERREEVTQAKKKVLSKKKQKALETIKKRKEKKQTLESLFESLQEYQFNAGTVQGLVSTAHRQDKIKKPEIEIERDPVFPKKIRSVSSSVINAKPKRIQQNYYETDSSEDENEDEATAVKEEEKLEKDEDEEPEIIEIKQEKIVSKIDKEVDENKKQRKERLNKFYKVLECIKGEHIPVQRDPEIENKRSKLPIFAEEMNIVEAINENAVVIVSSETGSGKTTQIPQFLYESGYTSKGHLIGITEPRRVAAISMSHRVGVELNDPSKVSYQIRFEGNRTDNTKILFMTDGVLLKELQTDLMLSKYSVIIIDEAHERSMFSDVLIGLLSRICFLRAKKSFPLKLIIMSATLRLSDFTQKRLFPSMTPKVIKVEARQFPVQLHFERKTPDDYLEAAYKKVCNVHEKLPDGAILVFLSGQGEVKRLLKLLTQRYPMKGKNVRGHLTKNRDKKKAVKEKLKLSSFAQQASTLLDGKTISTKPEAEDDTKADLDEFGVADCGILDDDFDDSSIHFGGDLPPPPAGLSPLYCLPLYSLLSSAKQQRVFQPPPEGTRLCVIATNVAETSLTIPNIRYVVDSGKEKRRDYDPITGVSQFNIHWISQASAEQRSGRAGRVQAGHAYRLYSSAMFEDFTVFSQPEIMNKPVDQLVLHLKAMNIVKISNFPFPTPPLPDQLEIAEKRLRLMGALSSDGTVISIFLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y141</accession>
    <name>A0A914Y141_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y141"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1294.t1">
        <property type="protein sequence ID" value="PSU_v2.g1294.t1"/>
        <property type="gene ID" value="PSU_v2.g1294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041523">
        <property type="entry name" value="ROQ_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048575">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052249">
        <property type="entry name" value="Roquin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139">
        <property type="entry name" value="RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139:SF54">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18386">
        <property type="entry name" value="ROQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21206">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1294.t1"/>
        </source>
    </evidence>
    <sequence length="819" mass="92177" checksum="C42CC84812477BB3" modified="2023-02-22" version="1">MRSIRSLSERIVTELICVVQNTVHLSAFLWSAVRARGCQFLGPAMQEDVLKLILLTLVNGELIARKTLVMYIVQTLLEDYPHVSKTCVGHVVQLLYRASCFNVIKRDGESSLMQLKEEFREYESLRREHDSQIVQIALEAGLRISPDQWSALLYGDPHHRSHMQSIVDRLHSPQLLSHALKELKTIVDGNSNAQILQSSLDNLATIAEIDSEVEPGWKLLSESIGIIETVIDEYVAFNKKWNINTTENRYLKNKNVYNSRTTTNITSNNERNGQQNISTNFNNFGRYKTRMCRDVLNKGTCPRGINCTYAHIYEELRPPHENDSKNDYSNDDLKGNGIHATKEMNGYSRMNGNERSHMQQQQQEMISMPMIPIQQMHETIIPENSPLMIDNTNGAFINVVPVVMHPQQLSDMSNEQMYNKPPPPPMQPPPPGLSGQLYMVQQPEVVVQHPPPIVIPNQQVQIIRGPPPPMQNHGGVYSYHIGPPQQMMQPPPSHIIYPAQNMWTPPPNQLFRPSDGFYATGLRNPQKTPERKDNNKTPESKSSSDKSSKQSWTSCDEGSLLARRNEVLSRLLQMDISKDECEDDAESHVSYTVANSVLFDDFEIMGGSTLDFPPLPLQSLPNVPNSVSPSIITETYVTSTATWTYPIAFEPYYTGGPAFTVRTVCPTSLLRMDSTKPAYQQSDSTVMSTIDAIEQPLVTSSIQRNNLSPQASYDMVDPCQLTEQLPRVMKANALTPEDPQDFVSSSIDKIITVRGKINEEMGSSRSSAVEKEQLKVELNIANRQLSTLDEQTKQTCLLKELKAIDEKIENLGSTNADSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1L6</accession>
    <name>A0A914Y1L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1L6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12676.t1">
        <property type="protein sequence ID" value="PSU_v2.g12676.t1"/>
        <property type="gene ID" value="PSU_v2.g12676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12676.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24317" checksum="9DDE5C75D70570C0" modified="2023-02-22" version="1">MLNPKKITFEAAPQKSALTPQQLDFHKYNLEAQQKYSKIIQQVEKNQKLISEWIKNGTIKASKVQAGIEKAKANGKSLSPEALQKVFEQGQVVQSNISNYLKVLAKQDSENCQKVDSTNDNNNVETKEAQIIEEEYEVQQQPPKSVSESPKELNPSTLIQLLEEVKLADKQEKPKESDSKLTEELMKAQKQIKFYKKLAADQAESIKKYGIGKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2A0</accession>
    <name>A0A914Y2A0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2A0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11929.t1">
        <property type="protein sequence ID" value="PSU_v2.g11929.t1"/>
        <property type="gene ID" value="PSU_v2.g11929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF333">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11929.t1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22505" checksum="946A6BAE7E0D1CC3" modified="2023-02-22" version="1">MLAYFENPNELATKRQQLNLLYLRQEQFVSSVLQLAENNETDRKVWTDIARMHMHNMSDHLFVAFEKYFLTSTEVKKNSTLEVWTFSTAIFFAVTTLTTIGYGNPVPITRAGRLACILFSLFGIPLTLVTIADLGKFLSEHLIWLYGNYLKMKHYLFRRVENRKEKREHVCEQCQHRGISPHMVPIEEQKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2D9</accession>
    <name>A0A914Y2D9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rotamase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y2D9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12949.t1">
        <property type="protein sequence ID" value="PSU_v2.g12949.t1"/>
        <property type="gene ID" value="PSU_v2.g12949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052273">
        <property type="entry name" value="PPIase_FKBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222:SF3">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12949.t1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24727" checksum="8BD44E32E6D9249F" modified="2023-02-22" version="1">MVMPGLDKGMRGMCDTELRKISVPFRLSRKNKSKVWKHIPNDEHWLNFNIEMLEVEEWSLEKQFKFMDLNNDTYITESELIRLAETMRKEFGKAWTNEDIDNILAAKYYITYFDANGDSKVDFEEFKQIIERDQASMENAAKQKTQMAEIDKTKNAKKIKPEKEGRKRDPGFAWILDFNNDGIVSIEENEMADQVFQGPPAILPIFSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2T9</accession>
    <name>A0A914Y2T9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2T9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13764.t1">
        <property type="protein sequence ID" value="PSU_v2.g13764.t1"/>
        <property type="gene ID" value="PSU_v2.g13764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009689">
        <property type="entry name" value="DUF1280"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06918">
        <property type="entry name" value="DUF1280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13764.t1"/>
        </source>
    </evidence>
    <sequence length="521" mass="59925" checksum="712319C7A62D7B9E" modified="2023-02-22" version="1">MKLQKENLKLKRGDKVNPYAERLKKAREGKRVKREQERQENDKDSLQDDEEVMDIQEAQNFISITSEFNSDRRNAGDAVVENEADENDSVAYVDVKKIQNYLYQEKMLNVSKKEVCSTESDGFTYKNLIKKLKPILDKFPVTQTADGKLIISLITSLKERLKNLIHKLPKNKRIRITIVADKGEKITKICYFFNDVKKPQATENLAVLCFYIGDDDSESIRSICESLNNEIEKLVNDGMVLEKVRYDFEFFITGDCKSICSMIGVQGGSAIRFCQHCLTADYCINGEIRTVSGIFCDARAIAHESANIQLTIARIRNIKKAHNSVNHEPFFTKIDHSHIVPPALHLLMALVNKLIQYFKNARLEEIIRQLKVDPVQGRSEYDGNSCRKIVKYFCDNVPESEGEIPMFHFFKTAAKIQAFSIAKNLSNSEIDQCGDAINRLFDDLDGLRNFKFNNKLHILRFHVMPFIVAHGSWGLFSEQGIERLHCLVNEYRKRVSSKNGHKKNIYAIKMLILGTFFHDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2Z2</accession>
    <name>A0A914Y2Z2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sema domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2Z2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13817.t1">
        <property type="protein sequence ID" value="PSU_v2.g13817.t1"/>
        <property type="gene ID" value="PSU_v2.g13817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097374">
        <property type="term" value="P:sensory neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="3">
        <location>
            <begin position="33"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13817.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31033" checksum="5F2C3D17259E52E2" modified="2023-02-22" version="1">MANMNKRFHILFFRNAQMYLLATDIICLITFLLIPFSYGQSRLISTFHSKTPISNVEIANNTIYIGAENFLYSLNAENLTLIQSVTTGPVLDSHLCNSELSSCIGSRARLSIVETNNYNKILHRLPGSLLTCGSVRQGVCELRSLDNISRVIKNSTVAVAANSQNASTISLIDNKNEKLYVAATYSYDSPYREGFPAITTRLLYNFLPINAGSLDGEAAVHIRAEYRSRFRVNYIHAFRDEHYVYWATVQNKYVVSTAYSKKVTKLIRVCQDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y344</accession>
    <name>A0A914Y344_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">F-ATPase gamma subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y344"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13653.t1">
        <property type="protein sequence ID" value="PSU_v2.g13653.t1"/>
        <property type="gene ID" value="PSU_v2.g13653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000007">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13653.t1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33726" checksum="8B0816A3839591C4" modified="2023-02-22" version="1">MLSKSVKWGSFVAANAVFEQQRGMATLKDISIRLKSVKNIQKITKSMKMVAAAKYAKAERDLKGARAYGVGAQTFYDNISDASTDTDAAAATSAKEGSKKRLLVLMTSDRGLCGGVHSSIAKEAKRILNERPADVEYKIVCIGDKSKAALQRLYPENFLFTANDIGRQPPTFEDASIAANQILNSGYEFDEGHIIYNKFKTVVSYQTTKLPIMSLDHVKSNDKLLLYDSVDDDVLQSYTEYSLAQLIYYAMKESATSEQSSRMTAMDGASKNAGEMIDKLTLQFNRTRQAVITRELIEIISGAACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3I9</accession>
    <name>A0A914Y3I9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3I9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1475.t1">
        <property type="protein sequence ID" value="PSU_v2.g1475.t1"/>
        <property type="gene ID" value="PSU_v2.g1475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037954256" evidence="2">
        <location>
            <begin position="22"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1475.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44418" checksum="512437B71859DD72" modified="2023-02-22" version="1">MILHSFFCVTFSLSILNFCFAIPFNPSLSSNSKDFSSSDDHHLSKPSNVAFIVGNYKFAKRVTTATTFAPPKSTPTSTTTLSPIRSGSGIGKVTGRTASKIEIESSTKPSLDVIGFQQSFNEPQPVNFGFLPVFDRWPKHLTKTVKQINLFPERGNNEWFAPPRADPRLSQFPAPTAPKLANTLNINSANKPFHQTSFNRPKVAFPMSPTTTATPSTTTTTRRSTSTTQRPKTTTISRSTIDINHVWNFAPITRSPFDAHDFQLDFGPPSTTTTSTPVIPKKSKSSPPGIAPPDWNGGFHESNKKARDMPSSKIFSSKSKSDIRKISIHKKEFNKIQKFNSCRTLNPAVDSYLHPKTDRSCEQTLPNFNNDGRCRCRYIVAFRDFAGCAVKFYSLCFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3K3</accession>
    <name>A0A914Y3K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3K3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14024.t1">
        <property type="protein sequence ID" value="PSU_v2.g14024.t1"/>
        <property type="gene ID" value="PSU_v2.g14024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14024.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18067" checksum="439998900436EBE2" modified="2023-02-22" version="1">MNNPSRDNRRYEVQKVKGSYEIIKIIATVHHPEYCGSFEEKVFFKDNILRLPTHLLSFHFHVVTEIELEEVIVYQLQVNCNSYKLLKPRQFFVQNIIFPVRGTSFKCYIKKFELYEPAEIHIVNPDGVTINDQNGDYHCTIEPKEKDMNVTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Y9</accession>
    <name>A0A914Y3Y9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Y9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13945.t1">
        <property type="protein sequence ID" value="PSU_v2.g13945.t1"/>
        <property type="gene ID" value="PSU_v2.g13945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13945.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13561" checksum="B1F0A0F8D516184C" modified="2023-02-22" version="1">MRNRIIDPDDEDNEEEVVTRRQRPRSRQSRTSQSSQGSGATTSHGRRRQIETIEEEDENETTLRPSRGRQIQRQNGEEMSMLQSQGNKSDSISEAVLATFALSSKGPIKEGDLKPLWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y495</accession>
    <name>A0A914Y495_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y495"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14261.t1">
        <property type="protein sequence ID" value="PSU_v2.g14261.t1"/>
        <property type="gene ID" value="PSU_v2.g14261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF209">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14261.t1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36970" checksum="6C3A3B9C529F619E" modified="2023-02-22" version="1">MELIAAFALSTSATSSSRLSKPFNPLLHETYELSNPELGFEFVAEQVSHHPPVSAFYSRGEEFEFYGNVEFKIKFWGRSLEVTPQSSFTLHLKAFNEKYTWQGIPCYVHNLYMGKMYMCWNGTINIKCLATDLQTEIKFAGPVKNGPDTMLYGEILQGKNRIRVLYGNWTEYIASTSLSVYFDMKHQWKKEYRSVEKSGNTELITMFPDSSMIWRVHSKPPGNKDYYNMTYFALMLNEKLSDPSKLPPTDARFRPDIRFMEEGDMDAASNEKERLEEKQRAKGKPRPPAQWFSLDKTGSFVFNGNYWKRDFSNCEDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5Z2</accession>
    <name>A0A914Y5Z2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y5Z2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14663.t1">
        <property type="protein sequence ID" value="PSU_v2.g14663.t1"/>
        <property type="gene ID" value="PSU_v2.g14663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14663.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="30683" checksum="27DB00B53D752689" modified="2023-02-22" version="1">MLLRQLKPSSLTSIYRISTEALKLVKVERVGKNQNVGLVALNKRPYNSLSSDLMAEVTQSLRAFEKDDSIGAIILTSTSPKYFTAGADIRQMLGNDFFEISGGTFLTNWNCFERCSKPLIAAVNGYVFGGGTEISMACDIIYAADNSLFSQPEINIGTIPGAGGTQRLVRSVGKSLAMEMILTGNKITAEEALRAKLVSKVFPVDQLRDEAIKLGEKIAEQSQLISGMVKESVTRSFESTLSQGLNYERGLFHKTFATNDRKEGMSAFKEKRKPKWTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8C4</accession>
    <name>A0A914Y8C4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8C4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13842.t1">
        <property type="protein sequence ID" value="PSU_v2.g13842.t1"/>
        <property type="gene ID" value="PSU_v2.g13842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13842.t1"/>
        </source>
    </evidence>
    <sequence length="382" mass="41827" checksum="FDF1AB316981B6FD" modified="2023-02-22" version="1">MIVRCRGLPFDCTKVQIEEFFASDCENHGIIDDGILFVFRPDGRPSGDAFVLFADDEAGKRALAKHKNRIGSRYIELFRTTQAEVQQVFNRSRASPQAVLQHLVPTVFGQKRDCIRLRGLPYEATINDIADFMGPHSRHITLHGIHMVFNNHGNPSGECFIQMDSEASAASAAHSMHNKYMEIGKKKRYIEVFQWSTDEIPAILNAAAGQISPTTPSTMSCSSGSSGIFPAGLLPQVPLQAFRGAPPTQMGLIPGQNFGATPFFHHPAAAAAAAHALTPDQLLFATSQLGQFPFYYSPEHLQLFAAQQFEAATSAQALYHHQAQLNASQFYHHHQHHSILSNNPAINVSFTAAAAAATQIPQNDFVEILPISAPPPLTLIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9Q8</accession>
    <name>A0A914Y9Q8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9Q8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16012.t1">
        <property type="protein sequence ID" value="PSU_v2.g16012.t1"/>
        <property type="gene ID" value="PSU_v2.g16012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16012.t1"/>
        </source>
    </evidence>
    <sequence length="113" mass="11898" checksum="C67733406ACB113D" modified="2023-02-22" version="1">MSNLARGGFPFNFPMFQGGGGAVAIANGPGAVAVANARGSLSYAEAIAVGENARAFANANSGDSHMTGNIVESNGGFYYWNIFQPFSFLYNFMRGHNTPAAPPSNALQQHEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA99</accession>
    <name>A0A914YA99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15690.t1">
        <property type="protein sequence ID" value="PSU_v2.g15690.t1"/>
        <property type="gene ID" value="PSU_v2.g15690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000002">
        <property type="entry name" value="Phosphoglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050060">
        <property type="entry name" value="Phosphoglucosamine_mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42946:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE (ALPHA-D-GLUCOSE-1,6-BISPHOSPHATE-DEPENDENT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42946">
        <property type="entry name" value="PHOSPHOHEXOSE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="9">
        <location>
            <begin position="97"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="159"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15690.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="29354" checksum="50490457666F45D3" modified="2023-02-22" version="1">MPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDAVEEAIEAEMEKEISCVDSAELGKASRIVDAADCGGLCKRCDLSHRAERAARTGANVIAIGCEPNGVNINAEVGATDVRALQARVLAEKADLGIAFDGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIPFARAKVGDRYVLEKMQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMARNHMSLHDLCKRHENVPADSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAG0</accession>
    <name>A0A914YAG0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase inhibitor</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAG0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14500.t1">
        <property type="protein sequence ID" value="PSU_v2.g14500.t1"/>
        <property type="gene ID" value="PSU_v2.g14500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL/LppC-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007609">
        <property type="entry name" value="PRK10257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00481">
        <property type="entry name" value="YbhB/YbcL family Raf kinase inhibitor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF12">
        <property type="entry name" value="UPF0098 PROTEIN YBHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14500.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14540" checksum="F017DEA26F481E92" modified="2023-02-22" version="1">MGYDGDNISPHLAWDDVPAGTKSFVVTCYDPDAPTGSGWWHWVVVNLPADTRVLPQGFGSGLVAMPDGVLQTRTDFGKTGYDGAAPPKGETHRYIFTVHALDIERIDVDEGASGAMVGFNVHFHSLASASITAMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAP3</accession>
    <name>A0A914YAP3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EMI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAP3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15828.t1">
        <property type="protein sequence ID" value="PSU_v2.g15828.t1"/>
        <property type="gene ID" value="PSU_v2.g15828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF109">
        <property type="entry name" value="PROTEIN DRAPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07546">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036919253" evidence="3">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="4">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15828.t1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20063" checksum="D7228BD411FE4AC0" modified="2023-02-22" version="1">MKIVLGGIYLFILLFSISNSQLTGDNICTKEVDKTIYVTKKVNQIVQLVTTQACPDFTRGFRCPVKKTGTKVTYKTVPEIKRVIETICCEGYSEVDGQCKQCEYGKWGPNCKKTCDCNGNSCDPVSGLCLYCPAGFTGEKCSETCPEGKYGENCLLTCLCENGGKCDAVTGEFVASINGSNVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAR3</accession>
    <name>A0A914YAR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16517.t1">
        <property type="protein sequence ID" value="PSU_v2.g16517.t1"/>
        <property type="gene ID" value="PSU_v2.g16517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="389"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="235"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16517.t1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50647" checksum="2ACBF45F132382C8" modified="2023-02-22" version="1">MQYYYECLEVYEKLVPEVKKHCKILRKLDAKFLVVRESYLEALSEFEEKKEHMTPQAFIQNKKVVDKGNDTLTRLANEKWKTANSLMVTIEYHLSRINGYVREFKCEIDSDSPGTSIEIEKRFLEANRKRVKEIQDLREAYPFLDDLFKIPEAEPETSEPVNEPVIEPIKINGHRQNIAVLLQDIGSVFRDDDATMLTLPEPSPSSNSVSPMEVSPGPHGNLSFTQKAQQMFKENKLGPGRPSNHFPLTNSTGTPEPINSSAPIPQFNSSSYNHGSISQIKTETPHPIASSSYSFPQDYSRLPQQPTSQQQYTLPSMYINSHPANPPQIPLQQQQHQPNATFLAQQQQQHHHQPQQPPQQQYSRPGQVRPPAAPNGNNVDGNEEDEDDREWCFCGEHSYGEMIACENDDCLYKWFHYGCLGITVPPKGSFYCPECQKNLGINRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAX9</accession>
    <name>A0A914YAX9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YAX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17365.t1">
        <property type="protein sequence ID" value="PSU_v2.g17365.t1"/>
        <property type="gene ID" value="PSU_v2.g17365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF154">
        <property type="entry name" value="GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765956" description="glucuronosyltransferase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17365.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42625" checksum="6DDCF3737B7ACEA5" modified="2023-02-22" version="1">MKKVLIIFVCIQLIQSLNILVYQTVPGSSHIAFSGKIVDILVQAGHTVDKLIIEWNPNVISNGTSLARRIRRFTLSKASPWLSATHVVKPFDNVFYHPFDDEPIFYRKTLSEFCEAMIEDESLLEWIKEGRYDSVLSSAYDACGHGLFHLAQIKPVMIYSPTALIDHWALMLGIPAMASYIPNPVRNNGQGDKMSLTQKIAVLADRTYQQQYVLPSYHEVQNSVFQRKFGPSFPSLTELAKQSSLVFVNSHPLLELSRPYSHKIQQIGGITLKKEAGKLSGEFEQILNDRYKGAIVFSFGSLAKTDQIPMEIHEIFAKAFNNFPEYTVIWKFDGENTEFMSNSSNIYPVKWIQQIELLRKCIYQFSKIKSRITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBY5</accession>
    <name>A0A914YBY5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBY5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17716.t1">
        <property type="protein sequence ID" value="PSU_v2.g17716.t1"/>
        <property type="gene ID" value="PSU_v2.g17716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17716.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15420" checksum="40C3936A8A32F08D" modified="2023-02-22" version="1">MSGRRSILQFRARHCFTAFIGVHCFIILLTGIAGFGDISEVYNLSYEKCTLNFTRIPWISTAAIVFFSVAFIELFFLLFYVGIFEEFFIKSLYLKILHSIQLLNTLIHLVKQLYQITPILTMIFLYHQCLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD82</accession>
    <name>A0A914YD82_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18182.t1">
        <property type="protein sequence ID" value="PSU_v2.g18182.t1"/>
        <property type="gene ID" value="PSU_v2.g18182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18182.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22793" checksum="5AB4AC53B78494E1" modified="2023-02-22" version="1">MLTISHPTFDNSGNYDCCVKTAATENGTQAEETTCFRTALTVTEYAHYLVENNANIALSLKRNNYLAIFDNSNVSMVACKFNGTDLQNNVKTMYTNTTFTPYFSIFNQFVIFETDAKNLGPYFCTSIDSNAKVLSKNFTLSEASARVYPWIGRNGGTTDPTYNGGDSNHNNSAIRDYGNMFNTVLPLFLLSAFIFNQIVFLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEF4</accession>
    <name>A0A914YEF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEF4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17827.t1">
        <property type="protein sequence ID" value="PSU_v2.g17827.t1"/>
        <property type="gene ID" value="PSU_v2.g17827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17827.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13529" checksum="1B1C25AFFB8DD108" modified="2023-02-22" version="1">MTLLVARNNSSPPRPYSLRPQADDWVQRYPAALHKDRKAGGLYGKCLFPASSDRPSTDKAFASDGARSGWGRCLLQMALQDCALLPALRPFRRTRACRSSSGSRSRCRARHIQSSGKTVSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEY7</accession>
    <name>A0A914YEY7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trehalase</fullName>
            <ecNumber evidence="2">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha,alpha-trehalase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YEY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1787.t1">
        <property type="protein sequence ID" value="PSU_v2.g1787.t1"/>
        <property type="gene ID" value="PSU_v2.g1787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF5">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1787.t1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12052" checksum="9A4A3642ED69E4F9" modified="2023-02-22" version="1">MTKYANEQWDFPNGWGNLNHMIVEGFRNSKSNKSQATAAFKIARKWINGNYKVFKATGSMWEKYDITGSYPSPGVGGEYKVQDGFGLTNGAILDLLITYKDEMTLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFA1</accession>
    <name>A0A914YFA1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFA1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17998.t1">
        <property type="protein sequence ID" value="PSU_v2.g17998.t1"/>
        <property type="gene ID" value="PSU_v2.g17998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17998.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15195" checksum="96853F2CD463C087" modified="2023-02-22" version="1">MYFFSITSTPPPTIPTTTTTQPDNTYYGSGTITSPGYPSLYPSNLNATYILQASPGKIVRITFNRINTERCCDTITIYDGAFENEKKVITTLSGDHSTPETYQSNGTYMTIRFLTDAVLSEDGFTADFVSYTSKLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFP4</accession>
    <name>A0A914YFP4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFP4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17577.t1">
        <property type="protein sequence ID" value="PSU_v2.g17577.t1"/>
        <property type="gene ID" value="PSU_v2.g17577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17577.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22021" checksum="0447936C12120369" modified="2023-02-22" version="1">MCVTKYILCHSILSSKELVDDPKLFVEGASPNDVTQGILGNCWFVSACSALTHNEELLQKVIPEWETQEWDPSNKYCGIFRFRFWRFGEWIEIVIDDLLPTKDGKLLFARSKTDNEFWSALLEKAFAKLYGCYENLVGGQLSDALQDVSGGVAETISVKKILDGTKDKDEKLFHLIRGAFEKGALIVAAIAVSVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFQ6</accession>
    <name>A0A914YFQ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFQ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18285.t1">
        <property type="protein sequence ID" value="PSU_v2.g18285.t1"/>
        <property type="gene ID" value="PSU_v2.g18285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18285.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24306" checksum="6A079E235C0E2D2A" modified="2023-02-22" version="1">MNKLSSKLWITGALTVYPKNAGNDSVASSIVPKIYRCDLKRLNLYDQVISLKERIFLCSYVKDLILNQVTVKYDNGTVVAFEKLIEQFPQLNVFEFTFTTPSNNISKNTFKELWKISYLSNYHCFYLYNIPENFEIDSFYSYMKKNKNTRVSLEFSDQISEEYKARLEAIVDEIIETQNHEYKPPYIKFPGMNGEKRNILLDIFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG67</accession>
    <name>A0A914YG67_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YG67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16335.t1">
        <property type="protein sequence ID" value="PSU_v2.g16335.t1"/>
        <property type="gene ID" value="PSU_v2.g16335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="47"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16335.t1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45437" checksum="6554CC90A992AE2D" modified="2023-02-22" version="1">MNKLIFKRFFSIHSVKRPIVLGIETSCDDTAIAIVSADKKVLNSKVFVNRIDQQRIGGISPALSAMQHRMFIDNLIEDCLDEISCRLADLDAIAVTSCPGLVICLKVGLERAISLSRISKVPLIQVHHMRAHALSSRLIDDSVEYPFLSLLISGGHCLLVLVKNPSEFDIIGIDSTTSPGECLDKVAREIGLKSKDRHLGAEVERLARLSDDDGCLRFSIKPPSTSGADFHFASIKNSFLNLIQQGKLDKLSQKDTVDLCASLQFQVTSHLCRKLHLAFEYLQSKDILQSQSKTLVLSGGVAANKFIFKAIEKLTNFYNYKLIVPPGRLCTDNAEMIAWTGIEMMEENPNVAIPWTSLPSSIYAHDRYPIGTSILRDEIHASKFKPTRKLKLQSLLQDQIYFTGKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIM7</accession>
    <name>A0A914YIM7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIM7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19359.t1">
        <property type="protein sequence ID" value="PSU_v2.g19359.t1"/>
        <property type="gene ID" value="PSU_v2.g19359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19359.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20454" checksum="2F292AF63DA5905A" modified="2023-02-22" version="1">MSGSSHFQIYNSTELLVNERSVKINHGYYNADNFIQINLMKDNVTTTQFNAYISVVKQNFAKLDGSCIVTNQINGSFTWASNANLSNGYDNNIVCNFAVIVPHGTSYLATVDQYSVETGVDHLNYDDGEYDFELNYHYQFVLESYSDGTNRTYFFEFITDGSYTASGFVISFVENGKCLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJ18</accession>
    <name>A0A914YJ18_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJ18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19503.t1">
        <property type="protein sequence ID" value="PSU_v2.g19503.t1"/>
        <property type="gene ID" value="PSU_v2.g19503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19503.t1"/>
        </source>
    </evidence>
    <sequence length="288" mass="34154" checksum="4B11B6E3041068C1" modified="2023-02-22" version="1">MAAQKKQEFIINVPKRDPLKRYSITRFNTNLHVDINQWPNKEVHLRREDNRREVLNDAIVQDYGAGSEYGAAAREEARRKKYGRLARSYQIDKQPWLLDIKESETKTRKYKSIVERTGEHADYWIFVKQGNKFLAHKVSEWYQFLPQVQHKVLDIEQAEEQFQQRNRVMNQFALKAQIQQQMKDSEEDGGKTVRTNLIIKDKDVISSDEDDDNEDEEDADEEKKKQKQRTNNQKKNQKKDKKVRVENGDEVAAYESDDGDDEGREFDYMSDSGSESDYEYRKSRHNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJU0</accession>
    <name>A0A914YJU0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YJU0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19797.t1">
        <property type="protein sequence ID" value="PSU_v2.g19797.t1"/>
        <property type="gene ID" value="PSU_v2.g19797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19797.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22672" checksum="AACCB48D29A1ADE1" modified="2023-02-22" version="1">MEVAQVKAISSTPNIKLRYNIIEDESNIAYIEELTGRIFLNSTPTKDKYTLKLLGTDGKSRAWSKLELTVKKVNVYEPEFDQPEYIFDLRSADLIGQIRALDRDENDTITYRLLNLQNLFYIDHEGMLSHKPSTSLIPGTTYELVVMAEDSQKHKNFVTVFLRTHGGGKSLDIILLSVLCIAGATIFVFIGMLAARKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLK1</accession>
    <name>A0A914YLK1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLK1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19783.t1">
        <property type="protein sequence ID" value="PSU_v2.g19783.t1"/>
        <property type="gene ID" value="PSU_v2.g19783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000003">
        <property type="entry name" value="endoplasmin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000003">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000003">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036996407" evidence="11">
        <location>
            <begin position="29"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="12">
        <location>
            <begin position="102"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="743"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="746"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="200"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19783.t1"/>
        </source>
    </evidence>
    <sequence length="777" mass="89537" checksum="0C4D5CE2C38C8A3B" modified="2023-02-22" version="1">MARKAKYLVFLVVVLLGVSLFSNSKVQAADDLEDETVTANLGKQKHGSATDDEVVQREEEAIKLDGLSVAEVKKLRESAEKHQFQAEVNRMMKLIINSLYRNKEIFLRELISNASDALDKIRLLSLTDPNVLNDTEELSIRIKADKENHALHITDTGIGMTKADLINNLGTIARSGTSEFLSKLLDTATSAEQQQDLIGQFGVGFYSSFLVADRVVVTTRGIDDKQYIWESDSSSFSIVEDPRGNTLKRGSQVTLYLKEEAYDFLEPDTLKKLVQKYSQFINFDIFLWQSKTETVEEPEEKEEKSEDGAVEEEKEQKTKNVEKTVWDWEKINSVKPIWMRKPHEVSEDEYNEFYKSITKDYDKPFAHVHFTAEGEVTFKSVLYVPKKLPQDAFQNYGKVVENIKLYVRRVFITDDFQDMMPKYLSFIRGIVDSDDLPLNVSRENLQQHKLLKVIKKKLVRKVLDMIKKLSPEQYEEFWKEFSTNIKLGVMEDPSNRTRLAKLLRFFTSNDPEKQATLAEYIERMKEKQDSIFYIAGTSRKEIEASPFVERLLKKGYEVLYLTEPVDEYCIQAMPDFDGKKFQNIAKEGLNLDDGEKAKEQYDALQKTFEPLTNWLKEVALKDKIEKAVVSQRLTTSPSALVASAYGWSGNMERIMKSQAYAKAHDPTQDFYANQKKTFEINPRHPVVKELLRRVESNKDDENAIYTAQLLFDTATLRSGFALQDQIGFAERIEQILRKNVNLSMDEQVEDEQEIEETAEEETEQSETAEVEEEHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLS2</accession>
    <name>A0A914YLS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20511.t1">
        <property type="protein sequence ID" value="PSU_v2.g20511.t1"/>
        <property type="gene ID" value="PSU_v2.g20511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036766623" evidence="1">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20511.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="12678" checksum="9B278C58EA53068B" modified="2023-02-22" version="1">MIFAKFITLFFVAALPFFVGSVVIPKTGSKICEIGKVGADSVKDLAKHLSDFTIAITAASKLLPDGKTVRAVAGAVTTALLHEDVIKILSYIGPIGGMIGACLGVGKVVLDVKKRGFLYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNE7</accession>
    <name>A0A914YNE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNE7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18858.t1">
        <property type="protein sequence ID" value="PSU_v2.g18858.t1"/>
        <property type="gene ID" value="PSU_v2.g18858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18858.t1"/>
        </source>
    </evidence>
    <sequence length="536" mass="60119" checksum="CC7728B32F243F0E" modified="2023-02-22" version="1">MVKEDSKLVVTFSPSSTDVKLGDFVKLGKYTVLVGFLCEMMILCQLGNQLFMMFSGATPKLIACGNYDLSHFDDKEACHQLSLIKANNASEDCLPQLDTQFDTVNMEWNYYCEGGKSVKHSTSVQMIGVMIGSIVFGQFSDSFGRKKAMIIALLGCIISMMATSFTNNLFTFTFARLIVNIFNGGSIAVMLVYCVENLPKKDRLWINNVVSWAPNYILYAIVAYFSADWRTLARVSSLLTIPPLLLLIFMSESAQFLAQKGKLDEAQAVIERMYKINGHKCDTVLLKQTLNREKESFEAKQSAGKTYTFFHLFYTWKFATFTIVLAFGYFVTSIVNYGIVYNMEKVSGSIYINAILIGVIRYALNLVMAFLDYKFTRIGRKLIHMGAWIEIVLACFATFLVHATQTEKQFSGLIRICSVSIVAVSAQLYITNGIVSGELFPTCIRNLSYSHCQFWTRVGVVISPQLFLLNELWGPLPYIAMGCLGLLDAIIFQTAIPETKGCQLLESMPTEDECIVGCRRRKNAAQKAELEKLNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNP2</accession>
    <name>A0A914YNP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNP2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21225.t1">
        <property type="protein sequence ID" value="PSU_v2.g21225.t1"/>
        <property type="gene ID" value="PSU_v2.g21225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21225.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21151" checksum="10B531B9FA632D76" modified="2023-02-22" version="1">MVKTTTNYKSEILRIFPPEEILRFPTNHNLLNDPNTVITTIECDPYQVLFKVSNGFKSTTIPKDRAYEFIQFYTAASTLTIKSLFLNPVMFPDYIQSAVRIMTPRFWSSCEQVIFLGLWHHDVVTSIAATFSGHLRDLIFRQCTVAGPFRLQRMIKRQMTGLEYINFDCRLSDNKDFLKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP05</accession>
    <name>A0A914YP05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19086.t1">
        <property type="protein sequence ID" value="PSU_v2.g19086.t1"/>
        <property type="gene ID" value="PSU_v2.g19086"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19086.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8794" checksum="83836B1922452D74" modified="2023-02-22" version="1">MNNPNHQQFPTALVAPWEPEILNRVFNAEGTPMVEPGIIRIQGNEGLPCDRGDGAPSVPVGNQKVADLQKMCTLVKPDMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPN9</accession>
    <name>A0A914YPN9_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPN9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21424.t1">
        <property type="protein sequence ID" value="PSU_v2.g21424.t1"/>
        <property type="gene ID" value="PSU_v2.g21424"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21424.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9765" checksum="2565D119A84BB62C" modified="2023-02-22" version="1">MSQMFEKDVSKNNLFQTSTDSFEPCSTTMGDETAGDTVDEAFTDYETFDESVREEDGEEKEFEYCDFYFEDDILEFLHFEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPT0</accession>
    <name>A0A914YPT0_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPT0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21027.t1">
        <property type="protein sequence ID" value="PSU_v2.g21027.t1"/>
        <property type="gene ID" value="PSU_v2.g21027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21027.t1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29969" checksum="21D46E76226F4FEF" modified="2023-02-22" version="1">MAKWASTYQTINSIKFVFNYRVCCCFGYTKKEMGFERFVDFSVGQRIICKSEKFPNHCSIWRFEKALDDDNDHTLFYRCSTCQADVNDLKEEFGMDFSSKVPILRVKEDGKLLDDPDAINGHICKWETSEYTEEGRAHARRLIMEFLMDSRMPLDAIQIRQKLKEAKKDQIFAYMNPDQKANAADIFRQFSLNDANKWIEWAANSMEVSPITIAQRDVTPPRPSLSRWQSTLSLFSPSRKKTNGSVTSLFSNLFKTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPY9</accession>
    <name>A0A914YPY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21091.t1">
        <property type="protein sequence ID" value="PSU_v2.g21091.t1"/>
        <property type="gene ID" value="PSU_v2.g21091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21091.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13674" checksum="C035FF98A2C23436" modified="2023-02-22" version="1">MQLVGADLGRLRRAMPDKRFTETTSILVALQTLNRIETLHDLGWLCRDIKSPNFAIGRGNEAGTVFMLDFGFARRYKDNSGNLLPPRNAAALLGTIHYAALASHYNQEQCRKDDLGKYSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQN7</accession>
    <name>A0A914YQN7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQN7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2138.t1">
        <property type="protein sequence ID" value="PSU_v2.g2138.t1"/>
        <property type="gene ID" value="PSU_v2.g2138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2138.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="48323" checksum="0AFB3D49C8FF9423" modified="2023-02-22" version="1">MSQEARKIIMNNIDVRFYCNVIGGRNYEHYKCFHPPSEAVSKFMTLMLKEFPCVLDYICDQHDKIHTILKKEGGECTITKSFSKGAQLCEDVVNIAIQDCFRFCILINNHHFVMPLRPHDVLLSENSFDKIRLGNYRGFFELFFEALIDKFNEKSLSFNPMCQKLLEDYSEAKKRNAALPMLAAKNRIKLENQQQDLKKKLATIIERNEKRVDRIGYLLKIHDKCISESENCMVKAKSSNVQKKSVDDLIAKTAEKEADMERMTKLLAALKDQLLNVKKSGMQRKNSIAILKAEKEKLQELDLTFLQLRFQNITTSIVDFVNHRKCELAHLNKLLSEVSAEQKNLVYENMKLLFVQINEEKEKLKRLEAAYKQYMFQVRQGTMLATLPPIDLKMFQLLKKQRQHQFLNLLKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSS0</accession>
    <name>A0A914YSS0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="4">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADH dehydrogenase subunit 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YSS0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20471.t1">
        <property type="protein sequence ID" value="PSU_v2.g20471.t1"/>
        <property type="gene ID" value="PSU_v2.g20471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="12">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20471.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26549" checksum="C223C020A7A0B892" modified="2023-02-22" version="1">MWILGGVIGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHKASDGKTRITAATKFFIYTQASGLVMLIAILALVFVHYNATGVWTFNYEELLNTPMSSGVEYLLMLGFFIAFAVKMPVVPLHGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFSLPLFPNASAEFAPIAMWLGVIGIFYGAWMAFAQTDIKRLIAYTSVSHMGFVLIAIYTGSQLAYQGAVIQMIAHGLSAAGLFILCGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSV3</accession>
    <name>A0A914YSV3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase family member 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 2,3-saturated acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44704"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:44705"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>docosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47228"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65059"/>
            <dbReference type="ChEBI" id="CHEBI:74692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:47229"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48216"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:64868"/>
            <dbReference type="ChEBI" id="CHEBI:74281"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:48217"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tricosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48220"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:90118"/>
            <dbReference type="ChEBI" id="CHEBI:90119"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:48221"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3244.t1">
        <property type="protein sequence ID" value="PSU_v2.g3244.t1"/>
        <property type="gene ID" value="PSU_v2.g3244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011945">
        <property type="entry name" value="HAD-SF_ppase_IA/epoxid_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02247">
        <property type="entry name" value="HAD-1A3-hyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF35">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="22">
        <location>
            <begin position="259"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="24">
        <location>
            <begin position="590"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="23">
        <location>
            <begin position="720"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="21">
        <location>
            <begin position="835"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3244.t1"/>
        </source>
    </evidence>
    <sequence length="991" mass="112427" checksum="6B853ED7636166D2" modified="2023-02-22" version="1">MSSIKAVIFDMGGVLIPSPMELWAESPQKLSANVSEKVSGKQITETLLSDECKHHFKSLECGEITIPDFEAIFTYFFNKQHGRKDKDILHIFHGMKPNNPSLKLLSEWKPVLEALQSEGIKIAVLTNNFWVDRARQFPTHCLDPKYFNVIVESCREGLSKPDKRFYQKALDKLGVNASESIFIDDLGVNLKSAKEMGFKTIKCQQTGDAIKDLENAMNFSLADYVSGTRQLLPREGIPKELLISYLQKLFNSNASEIIIRRFGHGQSNPTYYLKFDEKELVLRKKPSGKLLPSAHLIEREYQILKALYGHIPVPRVYDYNETILDTPFYIMEFCRGRLFVDASLPDVSPKDKTEMYQDFIRVLAKLHSIDFEKVGLANYGKKEKYMARNLQRWIKMYEMAKREEISEMNKLQKWLENSVPQNGNTTIVHGDFRIDNVIFHPTENRIIAVLDWETSTLGDPYSDLATSLLAHYCPTNSLIPSLARFETTEKSGIPSAQSILSYYHQLLNCQNPLNPEQWIFYVAFVHFRMASISQGIYHRSLQGQNSSTQAHTFKHFPKMFAANGLKLIHELNPASEKFGIFPTVPEALRPEALEIYKKVKNFIDEKILPREKEVEAYHEGPNPWVINPIIEKLKIEAKNEGLWNLFIPHHLDPKHQYGIGLSNVEYSHCCELMGLAQWAPEVFNCNAPDTGNMEVLIKYGNQQQKDRWLQPLLEGKIRSCFAMTEPDVASSDATNIQSYIVKDGDKLIINGKKWYISGAGNPQCKICIFMGKFEGWKKKPLHQQQSMILIPMNTPGITITRAMPVFGALDAPFGHCEMIFENVIVPYSNLILGEGRGFEIAQGRLGPGRIHHCMRLIGSAERALSCMIERAKTRIAKGKPLISFQTVRTDIAESRIEIEQTRLLVLKAAHMIDTVGAKEAQNEIAMIKVAAPNMAYKIADRAIQIFGAGGLSNDFPLASILINARTLKFADGPDIVHLETVAKQELKKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTG4</accession>
    <name>A0A914YTG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3979.t1">
        <property type="protein sequence ID" value="PSU_v2.g3979.t1"/>
        <property type="gene ID" value="PSU_v2.g3979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3979.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11668" checksum="F172FC0BD99F233A" modified="2023-02-22" version="1">MSSGHYTATMCGFDGKSVYNFDDDITRQVAFPNKPIQPYILFYSCNLPSRNLSSSSKSPLPTPAKKPNLNASISQKNPSFTVKKDNDNGIAKRVPANYFSMLNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUA3</accession>
    <name>A0A914YUA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g3723.t1">
        <property type="protein sequence ID" value="PSU_v2.g3723.t1"/>
        <property type="gene ID" value="PSU_v2.g3723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036895796" evidence="12">
        <location>
            <begin position="26"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1243"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="50"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="170"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="352"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="456"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="666"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="772"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="896"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="1006"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1326"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1346"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3723.t1"/>
        </source>
    </evidence>
    <sequence length="1412" mass="155633" checksum="BA0DD2017A2E227E" modified="2023-02-22" version="1">MVNIRWTHKCIFLIFILVYVRLNIAESDVNDLSDNDIKVLSPSQFPPVLKVKSTEGYLPELSEVGTTVRISPSLHADSLQILVDDEDLKPGMPPAIYQYVLTGYGAEKFAVDQRGYLYLNDPEVDADSDSSTYQLHVQAREVDTEPVRSSEPISITIHIIDVNDNPPTFASPIFTANVSASDPRERTVMQVEAKDLDAGKFGKITYRIGQVTGAPYQAFRYDEQSHELRATGPLNPGEQYQVLLEAMDGGGLMGKTVILVSAVDDFDVHTAANMGASLGAAAGAAAATAGQSVVSPQPISGGVSVSAFPQTIVPQAISEFTENSITPAPLLPLVSFTPSSLRRTTLEETTEPVQTLVTEISEATPPKAIVAVLGDDETRSKVYFIIADGNEEGKFAIDQDSGKITTVAEFDREETDMYTLQIEARSRFPDQALYWTILQVAVTDVNDNTPEFLDPQPISLHMSVDDLNEFGPNMRVGTLRIRDLDADDNGRVTLRIVPPMNRLFTINNQGEINVNGEFTTEHFGEHRISVIATDHGDPPLEARTTISVSIDGTFITQATQTPNEIDNNYEEEEEETESTFFTRATLPSFSTVSPHITNGVSSFPIPTTNWLPPSISQTKSTYQSIKPLTTQGQTKIPLIPTRPSPTPAAPSPRPSPPPQRIAPVFGTPVLSVMVEENEGELELATVEAHYPDNQPGTITYVMQAGDPSLFSVSSFTGTITLLKPLDAEADQEYVIKIGTAEAAALATESNLPHIATITVKVIDVNDWIPNFETNNYAFAVNTNTEPGTIIGQVAAFDQDRDEPNNKIRYKLINSDGMEKYFAVNGENGLITLNRDVKEFVGEKMTLRIEASDEGDPPQSTQADVVIDIEPSESEVIPKSEGTDFSSNPENGAIQFSLRNYTASISEAVRPPHLVQILTVLNKPTDTRFIMCNIISGNYRGAFSVSPGADGNCELRTQMQLDRETVERYLLNITVTSGHQTDFSLISITVLDANDNAPRFIFSNGLDLSTYFGGVASNAGPFTRILTVKAEDTDLGNSSLIQYELDSLSVDAKYFTIDKWNGEISTKQSMEVLVSRNRRNFFEMRVIASDSPTSGQQLSAKADVVINVVSEQHRFLTVIKGSQPQQMRSHEDDMVKAIRQFTGLCTLITLERLEEVSGSDDPLPTLRGVWYAVNPSTKKICKKQEFRKLFESSTLDLIAGKLKPWFTLDRILEHASALSSNGFDGDMDLDNIPWIPSDLQTTSVVLIVLAIAIGLIAVCGLFAICICWARYRHKQSTAYNAHPTIHQMPKYGAYYLQSGATIERDKNYETQMLELPISDEDFTMKNSSMRSRGHGIGMPQPQRRGGMMRDDSYGRDDTHSINTVQDHHPHSRQQNLNTRPYGRQHSVHDEGDFSIEESMYAINTPGRMDPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-06-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVF2</accession>
    <name>A0A914YVF2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g21491.t1">
        <property type="protein sequence ID" value="PSU_v2.g21491.t1"/>
        <property type="gene ID" value="PSU_v2.g21491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21491.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16241" checksum="57D1D1BB6E4911EC" modified="2023-02-22" version="1">MNNRKDGQKDVERERFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDVERERFQRVLDHIKEKMNEARRQLEAAKERIAEEVCNEFDTKLNRLIELYYDKLGELENSAPKNNKQMVKNLLEMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVU2</accession>
    <name>A0A914YVU2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVU2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4701.t1">
        <property type="protein sequence ID" value="PSU_v2.g4701.t1"/>
        <property type="gene ID" value="PSU_v2.g4701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4701.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7621" checksum="0EF2E73A0030EB05" modified="2023-02-22" version="1">MHPNTTKITRVSAKNTTTTEETKVAAENKNIVTIQSNTKTKTKTIDGEDTITAATQKTTAPTQTSAENAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVW2</accession>
    <name>A0A914YVW2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4710.t1">
        <property type="protein sequence ID" value="PSU_v2.g4710.t1"/>
        <property type="gene ID" value="PSU_v2.g4710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4710.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11790" checksum="164C1E7D85F3487B" modified="2023-02-22" version="1">MIDEKLGVDGIKHLIFSPAEPGKYLLGTMNDTATNIIEYYVRTRIPITHLSELPVVIKSPVGRQKWELLHDNIQVDKKIGSGENFVFTFKHGINVFSCFRCIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YW67</accession>
    <name>A0A914YW67_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YW67"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2319.t1">
        <property type="protein sequence ID" value="PSU_v2.g2319.t1"/>
        <property type="gene ID" value="PSU_v2.g2319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2319.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21119" checksum="7AE802F510528CB6" modified="2023-02-22" version="1">MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPDVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLDNIPEKWTPEVRHFCPNVPIILVGNKKDLRNDPQTIRDLARNKQEPVKSEQGKAIADQIGAFAYLECSAKTKEGIREVFEKATQAALQKKEKEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWF1</accession>
    <name>A0A914YWF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWF1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4437.t1">
        <property type="protein sequence ID" value="PSU_v2.g4437.t1"/>
        <property type="gene ID" value="PSU_v2.g4437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4437.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13842" checksum="90941C71E7C89CF1" modified="2023-02-22" version="1">MIPDVKTCLFCFEGDISMINASTMKNICKLKNLQNLESFALANLPEIFNVEDLSKFIKDRVNTKIQFSFNENISDEYKIQLDKLIDIVIKTELINCRLCYPGQNEVKNQILNNRYYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWJ0</accession>
    <name>A0A914YWJ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g4920.t1">
        <property type="protein sequence ID" value="PSU_v2.g4920.t1"/>
        <property type="gene ID" value="PSU_v2.g4920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1361"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4920.t1"/>
        </source>
    </evidence>
    <sequence length="1452" mass="166743" checksum="F3BE7A28FC78A36D" modified="2023-02-22" version="1">MAGVEDFFDSDSFDEKPTGASILCTRYLRSSIPIIGGEQIYEIILNDYSDRFWACRICNKADSTLDTVDEHIHSPEHVHAAFKVYKIYDAYKAEVDAAPESEHWAIEYKHLIEHIRQVGPLQPLAYYFTNTPNDLAKTFGITINKNGVKDVVEEITDSINIVHCNSCNEVYFSEIDKEKSFQAKFDHFATVDHQRCMYINNYLKSLTLTKKEGLPATVNAKEECDLLVSAEDNIAYGPPIGFQHCIAFGGQSEYFCNICYCLIRCEHVREHFSSEAHIERFLRSKTPSNYVNIEYEPIEKRRLKIESELAGQFKEFVELHHWDAEVPAPSLLREVAFPEKRNLTLTSFATLPPNVLICDICNMCFSSKQQSWEDHVFDEHHFERLVAKQKVERDPRSFIFENSDLPRLHRQKRAHWKDQGAIHDVQNYGEYALDLIFRDVVACEYICSCCYESFPDDNPQAVIYHTRSLAHIKAALITVNPVFAAKLLTPRNEVELKAMVLDYIQNRAAPVFETKMRVFDPTTSFILNSQVKIPRILLRLSLADPDSRDAIIADNGMANYNGEISIYDDKDYLCLTTALEATNLLLTRIDSKVVVFWCNDCHTSFSAFQRDLKTIWTDHMLTELHWNRTALLKQNELGLDCLLDGTSQYQPALFDQSGIKKKIPWYWNDEKNCFQFVLNNKCHLHDVYQQYNFQGMNRVFCSLCCDIIELSEDSLTAHVRSLKHMIFYLHKYYSQDVVQLEDILADNAKEIVVARLITRDHIADKIRSSETKNSRVLLFDARGGQCQYPVIQKIVEDENRIIKLGLFKVVTKINALPSASIYSIASLHNLPTPKPNKMNIKQQVLLHMVLKNVLSDNFPDKRPASLEDLVKEVPQPAPKPKVIAPVASRVKLGFNGQINVELTSTVAPVPAPIGVPAPVLQPTGVMAPVSVMPVPVRIDEPTPMDISDDEGPIRGRRSRSRTYSPEGRYDAPSWRNIRRRSRSRSPVRLRSDDPREYSRKHEEDNWRERDRGSSRRGDDHYKRDNDPYKQQKERVRSPSSSSHRNRSPPSSRNRSPPSLSSRSSRYEKEPARRAASPSSSARSLRYEKEPSRRGTSPRKYYDDRNDESPPLPRYAEDERPSSHSSRTPRYIEQEEYSNHSRSEMMRNEEELYRQYRLANPSPTPDFNQPPPSMIGDQFGRQRPTSANGSSHIIDLQMGQQQQPQHNDPNYDKILRNLPVITPHTTILPTIDLTKPPPPLPTIRPSVFPITYGAPPPSFGMPPPGFPVGPFSGMPPPQPQQQPIDQAELVKKAKMELYNRDLIKLTGRGQLVEYLMKQSSDPIPSNDPPLLFNEVLKTKQAIVGADQVAQVLCYGEPDYETYLCIMCQYWTTVSDMFKHLKDETHRLNYMNKSYKLQHAKNNFKCNSAFLKIWPEFLDYVDNSWKLGEEEDEMPPIVAKNGSKSFLRFIINND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWY7</accession>
    <name>A0A914YWY7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Electron transfer flavoprotein subunit beta</fullName>
            <shortName evidence="8">Beta-ETF</shortName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.</text>
    </comment>
    <comment type="function">
        <text evidence="8">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer composed of ETFA and ETFB. Identified in a complex that contains ETFA, ETFB and ETFRF1. Interacts with ACADM.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YWY7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4164.t1">
        <property type="protein sequence ID" value="PSU_v2.g4164.t1"/>
        <property type="gene ID" value="PSU_v2.g4164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4164.t1"/>
        </source>
    </evidence>
    <sequence length="243" mass="26987" checksum="143CF646C0E064D9" modified="2023-02-22" version="1">MRILVGVKRVVDYAVKVRVRADKKSVVTENVQHSMNPFDEIALEEAVKLKEAKHAKEVVAISIGPAKSQEVLRTALAKGADKAIHIEIDAKSAEQVEPLHVARTIAKIAKDEKFDAVFVGKQAIDDDANQTGQLVAGFLDWPQAMFASKIEHENGYLKVTREIDGGLDTVKVKLPAVVSADLRLNEPRYATLPNIMKAKKKPLEKKTPKDLGIDFTPQTEILEVCFLYLYMHLLPSFFFLPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXR3</accession>
    <name>A0A914YXR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4431.t1">
        <property type="protein sequence ID" value="PSU_v2.g4431.t1"/>
        <property type="gene ID" value="PSU_v2.g4431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF348">
        <property type="entry name" value="SYNAPTOTAGMIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4431.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21854" checksum="4B2608BD0E04B691" modified="2023-02-22" version="1">MEIGEICVPLKDLTQLHTKKEVRIVEELKFKTNAKKVGKISITTAIQNKVLTVGIIKVDDLPKWGIIGAPDVCVRVKIFQEGAKESIQVKHSRVIKSTCSAVYKESIAFLIQAKPADLTKTQVTVSVHDTSRSATGDDIIGSVFLGPHSIDKSEGEQWKNTIEHLGKEYKGSHNLKPPSINNHNPEVHVSETHSDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYR3</accession>
    <name>A0A914YYR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YYR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3177.t1">
        <property type="protein sequence ID" value="PSU_v2.g3177.t1"/>
        <property type="gene ID" value="PSU_v2.g3177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3177.t1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47397" checksum="624279B9D53CBCAB" modified="2023-02-22" version="1">MSTTALDESDREELCRLRHEVLQLQSSNDTLISSIHHLSGELLKRRNPFPLTPSSSSMIPMKRSKQIDPLNIFRFSQKSALGSQKKEASEKEDIGLPNEIMLHLFKYLSRSDLDRSALVCRRWKKIIDVHRCSLARRRIRLFKIIETTPNVIMFSAATSTQNIKYHFDLNLNGENQSPDVIHRVAKMLKYSKVRRLVMCGFRLTEVMVHDLVTIFKKADILFHRLEMIGVSLRNLSADTFQKFIGEHIIADQYFLDGICDSDSDHFGSRLFERTGIKKAEDVTIYDVSSINDEEVILDVGDDVLLDFIFGKYTDAVDRATVYLDNPAISSAFVYNALVRFAQESDLKHAIIHSEISHCRDQIVHNNRSTRFEYNVEVQAEYSSANKYTNSVLEAKVSKTADDEFVHVTLTIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYV4</accession>
    <name>A0A914YYV4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3228.t1">
        <property type="protein sequence ID" value="PSU_v2.g3228.t1"/>
        <property type="gene ID" value="PSU_v2.g3228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3228.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9384" checksum="700461CD52A38F01" modified="2023-02-22" version="1">MQNDQGEFVDMYVPRKCSSSSRIIHAKDHASIQLDFVDVDPTTGRLIPGKSTRYAICGELRRMGESDDCILRLAKRDGLISNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ53</accession>
    <name>A0A914YZ53_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ53"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5382.t1">
        <property type="protein sequence ID" value="PSU_v2.g5382.t1"/>
        <property type="gene ID" value="PSU_v2.g5382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5382.t1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53646" checksum="DB49171D2A854E44" modified="2023-02-22" version="1">MVVIITAFALEIWVYWVVYKCSKYITAMSLQSGGYGQQAKKHSNLKIDNLQTTSSLLEAIKMYTGYVVIEWLFFSKKTTPSDVVVKQQPKTKTLAIKNVEPQVEAQSPKAEETIQLLKDVTTKLKSEESYLTVQLKNPTVQTKAAENFSIKLKSAEKVLKNVKRQQLPPYKTKTLIKPKTADVIQNLKIEAAELQPFTLNLQQKNPTVHSKEAGVTKQLKIEASELKPMECTLNVHQKNPTVQSKVADDFVIKLKSTEICEKVVIKLSSPKKPFINTLSTSEASKKSHFHKPSIPTSSTPKKLVSIEIQTDETSFNQNIAIKKQQLNDFGYDSEAYSNNINPKSFSSFICDKYCDDQKSPITTSSGFASVSDADFSPNQTVSPNSEPSYSSSPDITDATTTFVTFLFKNDETFAVEVYKNGKKEKIKNVFDNTWTPLYFSMARPSPEIGETAQIHCHQFREHVLYVRRFINITWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ99</accession>
    <name>A0A914YZ99_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase metallopeptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZ99"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5276.t1">
        <property type="protein sequence ID" value="PSU_v2.g5276.t1"/>
        <property type="gene ID" value="PSU_v2.g5276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF310">
        <property type="entry name" value="MMP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036895525" evidence="8">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5276.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24977" checksum="E7F47F26CF65452F" modified="2023-02-22" version="1">MNFLFVTLIFLQLINTCFGGYDLINDLDKQIRKKRYVLSTRKWPIRTLTWTLKKTPYISNSDKFLIRNTLHRAFNLWASVSSLEFVELPEGHRWEPDISIAFVKGKHGDNMPFDGREGIVAHAFYPTLGILHFDADENWTLNQPTGINLYQTAVHEIGHLLGLEHSTDTRAVMYPKNRKYDLNYELSDDDVRGIRRLYPQLKKYRFRKFAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZH3</accession>
    <name>A0A914YZH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5343.t1">
        <property type="protein sequence ID" value="PSU_v2.g5343.t1"/>
        <property type="gene ID" value="PSU_v2.g5343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5343.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28347" checksum="AC2A5017B2023F1B" modified="2023-02-22" version="1">MDKFSRMVFKNVLLIGKYVPTDMNQSIQLPLRKTPSIAFSNDPPLTEMGFRISQLIGKTFAENGIIISAVYSSPSLRCIQTAQNLIKSQIYDLKIRIEPAFYDFAGIKGKGIPIFMSVNELLENNFPIDKSYDPITPVSHLSKFTTETSVEFFKRQSNNIYHLTKQSPNGTVLIVTHPCTIHAAGRELIGKTQHSLNTADMLRVPFNYPYCSAVALKPTPDGLWMIASQALPILNFSHFSNRFNHHFFAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z027</accession>
    <name>A0A914Z027_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z027"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5529.t1">
        <property type="protein sequence ID" value="PSU_v2.g5529.t1"/>
        <property type="gene ID" value="PSU_v2.g5529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5529.t1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46445" checksum="88C88EB74EA99973" modified="2023-02-22" version="1">MLTRFLFHHSFFIFSSIFFSFVQTRELRFVQAIWRHGDRAPGKLPYPNDQYNEDYWPRGWEQLTNLGAAQLEELGNFFRNRYVGKFVNETFKASEIYILSSESDRATASAQAFTDGMFQLNQCNSNGGARMAPVPIHTTGTEDEDFLLKPTSTDCPEYDQYFTENASGFLNELATKYADLYTFLSNVTGFGPGITTDNVADLSNVKREMAHNLTQPEWFNQIWPQYDGNTTLDIISEIDRQVRLNEFSSDNLHKFRGGFLLGDWLQRIKRVANKSQSNPSKMLLYSSHDGTLLSLLYSLKVADGEQIPYAAAVIMEIYEGDVGSFEVEIYYRKNGDLLPRIVPGCDQACPVDKLYGILKENAYFSLDKVLKKCKVGKNNADNNRDNDKKKHDKHKNNKKDSSEEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1I8</accession>
    <name>A0A914Z1I8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z1I8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6219.t1">
        <property type="protein sequence ID" value="PSU_v2.g6219.t1"/>
        <property type="gene ID" value="PSU_v2.g6219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000016">
        <property type="entry name" value="probable D-lactate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6219.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35351" checksum="BDB6C34E13F785FE" modified="2023-02-22" version="1">MDQVLEVNEQDFDCVVQPGVTRTKLNEVLRESGLFFSVDPGADASVCGMIATGASGTTSVRYGTIKNNTKNLEVVLSDGSILYTRGKGRRPWKSSAGYNLTDLFIGQEGTLGIITSACVHLHPRPQAFSAAVCGFKSIKSAIDAVVNIRQMAIPIARIEFLDEEQIKACNLYNEGKSEYLAERHEECPTLFLEFHGASESEVEQQAITAEEICTANNGRKFKWSVDSQVINRLWSARHHAYYATIGTKKGSKGFSTDVCVPISRLADVIVNTKKDLDEHEIYGTIVGHVGEGNFHVLLAVDEHNSDEMKQTWEFSDRLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1L1</accession>
    <name>A0A914Z1L1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1L1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g578.t1">
        <property type="protein sequence ID" value="PSU_v2.g578.t1"/>
        <property type="gene ID" value="PSU_v2.g578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.810:FF:000001">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g578.t1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13240" checksum="66CB09DC4F3EFDBE" modified="2023-02-22" version="1">MEKTMSNSTPTPAAWRLGLVGRKVGMTRVFTEEGESIPVTVLDVSNNRITQVKTPAVDGYAAVQVAFGTRRATRVTKPQAGHYAKAGVEAGSILKEFRLTPLLSPSFSAGSVVAVESIFRSGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1T2</accession>
    <name>A0A914Z1T2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1T2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6070.t1">
        <property type="protein sequence ID" value="PSU_v2.g6070.t1"/>
        <property type="gene ID" value="PSU_v2.g6070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
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        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
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        <property type="entry name" value="Znf_TFIIS"/>
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    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_TFIIS_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
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    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="28"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
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        <ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
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        <location>
            <position position="94"/>
        </location>
        <ligand>
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            <label>2</label>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6070.t1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15805" checksum="393F8B9FB7F89B65" modified="2023-02-22" version="1">MSQISDDFMEEDEESKKKFSGIKFCPECNNMLYPREDKSERKLTYTCRNCDHSEDAENPCIYVNKLMHEIDELTQIVADVVNDPTLPKTYDHVCPKCQNKQAVFFQAQSRRAEEEMKLYYVCTNRECNHRWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z292</accession>
    <name>A0A914Z292_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z292"/>
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        <property type="protein sequence ID" value="PSU_v2.g6828.t1"/>
        <property type="gene ID" value="PSU_v2.g6828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6828.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22713" checksum="D7D80464BAE66AE5" modified="2023-02-22" version="1">MLSTQNNQYHTLDELNGSESDGYVTFGSVSDHIQQSSSYNSEDEIASKKVGATIFNDEESMSIALKKAQILVDQEEKEDESEIDEETRVEILESKGKSAVVIIGEEIIVDYSGCCINKKWASKQTMDLAQKQSLLYQKYYLGPRSDVKAKDACSIRSSWHLYHRIEKSLSDAAASLSDTFQLPSTLHLYIIYRRNDNGQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z295</accession>
    <name>A0A914Z295_9BILA</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z295"/>
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        <property type="protein sequence ID" value="PSU_v2.g4373.t1"/>
        <property type="gene ID" value="PSU_v2.g4373"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASpartyl Protease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
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        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF8">
        <property type="entry name" value="ASPARTIC PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038093172" evidence="12">
        <location>
            <begin position="20"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="65"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4373.t1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47622" checksum="2E4DE9D45390E2BF" modified="2023-02-22" version="1">MFKILSILLLLIVCEIGYGKIIQHQIFKKYDRVTKLIKSGEWKQIIAQSRNSGNETLYDWYDDFYNINVTIGTPPQTLSLALDTNSAVTWVIDSACYTDYCVGWTVSDYDKNQYFTFNTTTYKNASRLFSVKYANGDEASGWVASDVFKFDGFSLSRAEFGLAEDVNKHVGFEPIDGYFGVGWPTFDVDGMTPPIWNITDQMDQQMFTIWLDRHPSFLEYGSNGGQITIGGLDTQNCNVNFNWVPLNTAAQWEFKLDSFSISSYTDSKTVAAISDVGKSFIGAPYWALNKIEKFTYASYDLEQDIYFVHCNRTGLPDLIFTIGGVKYHVPQSEYVLDLNMSNGMCVLAVYELKFNGFSPTWILGDSFIRSYCQAYDMQNRRVVFSTAHHSEIQKKDYNKNNLFSNCIFNKPESFPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2D1</accession>
    <name>A0A914Z2D1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2D1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6518.t1">
        <property type="protein sequence ID" value="PSU_v2.g6518.t1"/>
        <property type="gene ID" value="PSU_v2.g6518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6518.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="9170" checksum="1904FD37542DDED8" modified="2023-02-22" version="1">MSPSKIPKQKKDKKEKKEKKEKKEKKNKKEKKEKKDKHREEDEKNRDHLRESYESDKDKKKHKKHKKKDKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2L2</accession>
    <name>A0A914Z2L2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Microsomal signal peptidase 12 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2L2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6309.t1">
        <property type="protein sequence ID" value="PSU_v2.g6309.t1"/>
        <property type="gene ID" value="PSU_v2.g6309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6309.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12921" checksum="9D7DED48FBFD2BF6" modified="2023-02-22" version="1">MDGIIQMLPAPLRRFSTYIDFAGQSKAEKIFQVIIVIASIIGFVVGYLLQQLWLTFAILGGGFVLANLIVLPCWPYFRKNPINWKPNPVDERPTPAAATKKEGASPNPKKDGKKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z347</accession>
    <name>A0A914Z347_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z347"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4677.t1">
        <property type="protein sequence ID" value="PSU_v2.g4677.t1"/>
        <property type="gene ID" value="PSU_v2.g4677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4677.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24304" checksum="A21A22C1225B3198" modified="2023-02-22" version="1">MPKKASKKSEPSDMEIDKNIGEEEEEGSGEEVEDDDASDEEEEEDELMNDNTEAMEKLTFDFEAFPLDTGDVDGLVNLLTQIFLRTNVDCEAVAKALVEMSPLGCVYRPAEEVEDEDSENAVYGVLSMLELGGIAPFQTEIANLFLNRARKVATPDIVKKFEAIFNNKDNKQKNYLLVNERMLHFPDQIAAPAFKSLKLVHIYLSFLWLKYIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3H8</accession>
    <name>A0A914Z3H8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3H8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6452.t1">
        <property type="protein sequence ID" value="PSU_v2.g6452.t1"/>
        <property type="gene ID" value="PSU_v2.g6452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6452.t1"/>
        </source>
    </evidence>
    <sequence length="399" mass="45451" checksum="55C44E5DD491A419" modified="2023-02-22" version="1">MVEKNDGTQLPEKVEDEMQKIRIERLLKVAEKVLKENKERCLRSFAFYFFILIIFGIPLWWITTSPYRASLERFSFNEAVFGDLMDDQNSEKGFRDNSPDVWNEISISAAYNIHLIFVHEENDNSKWSNIEKSIVNEVNKMVNYLSDTVFFSVTTEHFWDLYQSDIFSKKNDKKLVLNGADMTRFITAIDKHSSPIISTDPLLKLVFVLTNDGIEIDGIQSNGQTFASWGSIINASPGKSDDYLNAIYESFHSLLGAQLSSRDVPSTFKHPDHAAWNNFRHRAFSENIHKAEHFITAINTLASKMPQLVITPEVGELVRKSKNFVKEAIAEEDALKASVARLLAERAADHSSLIGTGDLTSSLKIGIYVPIGMPLLLPVIEVLLRYSWGRYKNRHIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3J1</accession>
    <name>A0A914Z3J1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z3J1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6466.t1">
        <property type="protein sequence ID" value="PSU_v2.g6466.t1"/>
        <property type="gene ID" value="PSU_v2.g6466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="90"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6466.t1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44496" checksum="F9805C4DFA52320D" modified="2023-02-22" version="1">MQYKASQRLLNPNDAAAAINNKRQSAINNQLNQLHLSSSAMPSSMSPSSIQPSTQPIISHATRRRMYPRISKDGTDKALVSMGEMVRQRWLIKGMIGSGGYGQIYYALDTRHNDHVAVKVEPTRRSGKTVRRMILEQKVLLRLQGRAHVALMYGSGVEHDLNYIVLQLLSVNLGELRKQCPLKRFSKSTAGRIMQQAIAGIRDIHQIGYLHRDIKPANMCFGLSESSKHRLIIVDFGLVRKYVNADGRVRPSRDRAGFRGTLRYVSPRVHDRQEQGPADDLIALLYSLIEMVHGELSWRKMNDPTDIKAAKDELIRDEYRTVSCKFGNSFREYARAVSSMAATEEPNYRVLQEMMRDFSGNKSISSEYDWENEFCDVIAETEINRHLKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4D1</accession>
    <name>A0A914Z4D1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4D1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5110.t1">
        <property type="protein sequence ID" value="PSU_v2.g5110.t1"/>
        <property type="gene ID" value="PSU_v2.g5110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5110.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="11086" checksum="DF1E28E56879D58D" modified="2023-02-22" version="1">MSGRGSPRKRKAMTPVSEPLSPEEDGDDYQMKRQRNNVAVCKTRQKKRQEEQETNEKVNKLKEENEVLERKVEAMKSELKLLKEMIVAVAPGSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4L4</accession>
    <name>A0A914Z4L4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4L4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g693.t1">
        <property type="protein sequence ID" value="PSU_v2.g693.t1"/>
        <property type="gene ID" value="PSU_v2.g693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g693.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41814" checksum="AA97D49A404B0E44" modified="2023-02-22" version="1">MDSELDSNVNKPDEDLYIVDTEGNEYIAMPEKAAPQPFPSCNRWLKGDPKIAAKYQWRQGKQFCDGNEAEPSSESEDEDFNKILQTNYVDNDEGEVVKKPKEFKKAMDNTLDKEYYDLPNFEALSLTCLESCVIEPFGKVFQHYDALVMIKAYPNKPYLDMDTMLFTSEKIPAGRIYELMGMVEDPLYNLLFASVKETTKLPVGTELFYAPSADESVTKFLYLEDLRNNSKWQTTDEGLGESDDEVDEETQYYDKLKKQLEEYEQRKRGRSESVSSSTVSKQFGPSQPKQRRGNNFTPRPQNFNQNRHSGNVRAWRGQHSSPYNPNQQVNPFALPPPQPSYYVPHGLFNYPPPRSSTPYPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4Q0</accession>
    <name>A0A914Z4Q0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4Q0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5226.t1">
        <property type="protein sequence ID" value="PSU_v2.g5226.t1"/>
        <property type="gene ID" value="PSU_v2.g5226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5226.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13880" checksum="DB9A18BA5A09BD9F" modified="2023-02-22" version="1">MAPAPAPAPAPAPAPAPAPAPAPAGPKIYSSEQIREATISTCNADAEIYWKIISDSVRLHTEVNGRDFSYICEKLQKIEQKLGGSWTCIASDHKFFSKSQHEDQITNIIIELDDLFIHLFKPIHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5I2</accession>
    <name>A0A914Z5I2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphoenolpyruvate-protein phosphotransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5I2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7937.t1">
        <property type="protein sequence ID" value="PSU_v2.g7937.t1"/>
        <property type="gene ID" value="PSU_v2.g7937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050499">
        <property type="entry name" value="PEP-utilizing_PTS_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46244:SF4">
        <property type="entry name" value="MULTIPHOSPHORYL TRANSFER PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46244">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE-PROTEIN PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="7">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="93"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7937.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22272" checksum="2241AD901081C079" modified="2023-02-22" version="1">MADELTPSQFLELDKNHLKGLLLKSGGTTSHTVILARSFNIPTLVGVDIDALTPWQHQTIYIDGNAGAIVVEPGEAVARYYQQEARVQDALREQQRVWLTQQARTADGIRIEIAANIAHSVEAQAAFGNGAEGVGLFRTEMLYMDRTSAPGESELYNIFCQALESANGRSIIVRTMDIGGDKPVDYLNIPAEANPFSVIARCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6Z1</accession>
    <name>A0A914Z6Z1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6Z1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8100.t1">
        <property type="protein sequence ID" value="PSU_v2.g8100.t1"/>
        <property type="gene ID" value="PSU_v2.g8100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8100.t1"/>
        </source>
    </evidence>
    <sequence length="557" mass="64991" checksum="6EE2BDF1ECE1E2F7" modified="2023-02-22" version="1">MNYEYSIDYKMAYDGDGERRDGGEDENEENNRIKPRGIEWIRKKVENSGPPNVKSAHELRHFSEDRIRNFLEQLVKENEMDISLFLDKLSLISSLTERHYVNTFELFIHNTESCIGTNEECFRRSGNIAALIGSRTQEPANVIMIGCDFGIHGNDLIDYSPIPCGMLMDAMQTIIVSNLSFVNDIIFSYNIKGKKYTDDPYLFLLKTYRVNAFIKLSGSAGREILLSNDKSDMLIEYLNNVLDKPSNMLIPKILEKYLNKKLIQNGTEIEHGNLMELDIYYPKIYDSIMDFIQFKKVGAVQRVGENLLSFVYALSGIPYFNLKRGKFLGFNYSISDEYYGFPFLRSHIYDFGKTVHTVTFIFLTFIIFIISSLSFIYTCWHRKLNPKKLLVLYFTCIGSILGSNVVLYFLSSLFDYLPIQWNSGTSFLRNIFLHFLLTISMYFKFTENIESKFSIDYEQTYFTYGIFFPLLFLTIIFTADIVDTYFRAVMKEHFEGYKLLAAIFGFLIAFLISNLTFVSRNIIFDWGTSEYIPANDCPWLNFPEISQHRERYWQYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7E8</accession>
    <name>A0A914Z7E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7E8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8251.t1">
        <property type="protein sequence ID" value="PSU_v2.g8251.t1"/>
        <property type="gene ID" value="PSU_v2.g8251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="159"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8251.t1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41573" checksum="33EA89CD17651C04" modified="2023-02-22" version="1">MQVFSILLDSDSNAYFGNTIVNSCVILRSNKEIKVRSIAVSIRGKAEASWVQNRGKRHDKYQTFLLYIKEDFTLWKCPDTSNKLPPGEYQFPFQFFIPHDAPPNIYSDYGNIRYWIDANLDIPWGFDKSVKLEFSVCPFVDLNAESRFAIPVMKHVQTTSNPLKNVTIKIPKMGYVYGESIPLYVEIGSNLISSITYVEMGIQRIWEFTAECLEPYIFTPTEPMTKIASKKYPLHRISSFPIEKNYSVTLFHSLCLPPLPPSYDYCGFIKVYYSVFVKLHTKAKFSSGPTVCLPIVIGTIPLKEMLTEVGPCVIGDDDYIHPPIPTSITSEFNFENVQFWEEKSLTDSEADDIYVWQPKSVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7G0</accession>
    <name>A0A914Z7G0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7G0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6181.t1">
        <property type="protein sequence ID" value="PSU_v2.g6181.t1"/>
        <property type="gene ID" value="PSU_v2.g6181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6181.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20969" checksum="04B2DACEF80BE087" modified="2023-02-22" version="1">MGEKFLEIIRRFYFGCESTFDENDEKHFCCFGRVHVLTAAKYIAIFQYIFLALYALFFFCSAESYAYAIFYVFLNVGFTSILTVIFGAFFNYLSGSKIGWFKPHVLIFSGHGLRCYLPPFDTSSLNKEQIISIINSDLFSNGVSEAFLAKYGKFLFQLGPEGIGGKRSKDAKKVSKFQGGGSHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7W4</accession>
    <name>A0A914Z7W4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7W4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8421.t1">
        <property type="protein sequence ID" value="PSU_v2.g8421.t1"/>
        <property type="gene ID" value="PSU_v2.g8421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8421.t1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14137" checksum="8052986CDC201F53" modified="2023-02-22" version="1">MATISRSVTSYFRQSTKKQWIDYFMSTHFWGPVANWGLPLAAIADLKKNPDLISGNMTVALMGYSSVFMRFAWHVQPRNLLLFACHFTNVAAQTTQFLRWMNYHYLHVINDPCAPKMITLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7Y6</accession>
    <name>A0A914Z7Y6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7Y6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8799.t1">
        <property type="protein sequence ID" value="PSU_v2.g8799.t1"/>
        <property type="gene ID" value="PSU_v2.g8799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="808"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8799.t1"/>
        </source>
    </evidence>
    <sequence length="1034" mass="115863" checksum="50CC0957942464F0" modified="2023-02-22" version="1">MAEERTLYICNIDENVTKDLLEEIFTQVGPVESVSLIAESVPFSIKTMDGLKLYGTPIVVKPRANTQQDRLYKNQYGNQRRHSSGPHRRDSYNDYVPDYQPHSARRSVHDNVAHAPSRFSQTPGQYPIHSSLRSQDPLDSHSSHRPRTFGGYYVGPKSNVQPPRSNSAGHRSNSHRNGNSIYGLAMETQLAKLNIADKKLIKPAIQFVSKAQGLAGAYILNIKAGTKIYRYDVEITKVHPTDTLKNKTLTKRAPDDGEASLRKIFCMEVISTYKKSTNNFGIGGKGEYYVYDGGKQLYLAAPMVIDAGKKRKDFTSDEFSPFCKNQLADCSVSVEINASQQHEIDISDMKSMMDTRENPADRSIAQFLDLLTSQYAISSLSYVSLGLGKLFQRRGTVMQNKTMELKSGLSKGVHLIDKDGKNTVALIVDAKKTAFFNADFLHKILRDANVLGKDLRYTLPPMSQLYRDVRCTLKYAQHRSIVIMNIDSECARNVKVNGGSMVEYFKKNYKIDIDPSLPVVRTDKALFPMDTLIICPNQRVPMEKLDDQIRRVILTNTAVLPNERFQRLRDEVAEAKILPTNAIMEFFGVKIVPSMVEVPVQIREAPVIVSSKNGKQLNERVERGAWKMSGLLAPTALLAGGFIVLHPRGFDPKSFVSQIITTAAKHNLKIGTPSYEEVDFSSYQSMMPKFKDLMEKKARFVLALDYQRSKSHHNLKLLEREFQVLTMQVRIETATRPGGLGQTLENLVLKANAKTMGVNFMPQIEKCGIIELRKKDLGDLSSHDSAVVGLTGNCGKQPTTILGDYYYQPSTHEVLDPDLLKSNFSKLLERYVKNRGYFPEHIVVFRDGVGNGQLHKTVQSEYPVFEHVCRELKGQNAFPNIIYIIVTKKHNKRFAIGPVGKETNCLPGSVIDKDIVRPDIPEFYMQSHRPIKGTAKSAHYSVMMNPKNFGLDVLEAFCNHLCYNHQVVTSAVSLPESIYHAKEMTKRGRNNLNAKKGANQGKVPTMPNGLTDYNKVSAALSYGGIGLGNVKFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9J9</accession>
    <name>A0A914Z9J9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z9J9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9348.t1">
        <property type="protein sequence ID" value="PSU_v2.g9348.t1"/>
        <property type="gene ID" value="PSU_v2.g9348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9348.t1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17147" checksum="0F9EFDE9295C391B" modified="2023-02-22" version="1">MSTTERTFIAIKPDGVQRGLVSKIIERFEVRGYKLVAIKMVQPTQEHLETHYQDLKTKPFFAGLIQYMKSGPIVAMVWEGLDAVRQGRAMLGATNPLQSAPGSIRGDFCIQTGRNICHGSDSVESANHEISLWFKEDELCSYKHNSQNLIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9V7</accession>
    <name>A0A914Z9V7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWWP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9V7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8707.t1">
        <property type="protein sequence ID" value="PSU_v2.g8707.t1"/>
        <property type="gene ID" value="PSU_v2.g8707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8707.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="53618" checksum="E6705B7CAD2E296F" modified="2023-02-22" version="1">MARKTASTTNAITTYVSCTLKTGDIIWVPYRKSPKWPAVVKNVYPKKVTYFFLPEPQKGKPATFKTTPKSACLFKDSDMLPPNANKDLQEAYKAAIGIIRGEVQLRCISHNTNKQNSDPDPVSPSTSNTSSLVDVPVKKPRRSIITEGQDLSPFTVILLDTAEIPNWPVLFLEKSDELEVLVRRFPLTENPEGQRYPLNWCHNVTYGGIEELIASNDCKGCPNYVRALVAAQEFMENPQNYVTLPDGFTFPQKPRPLVVETKRTIKREKQEPKNEIKPDIEMDEEKDAKNVSKFNQNGLALANLSLSSSKNDIFKAMLSYEAREHVEKMFAGQYECKRNTEYQRAEDARDATFSFFCGDLLNFAELEMVIAEIHNWIALSPKLPKMSLLGEMHYVSKVVLPELCIFALARINQISPKDAESLFVKSSKEKSSSLSSTAYQGRRSSQTIETSQHPSVSKAGNSFEQLLRAVSIERSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAJ3</accession>
    <name>A0A914ZAJ3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZAJ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8796.t1">
        <property type="protein sequence ID" value="PSU_v2.g8796.t1"/>
        <property type="gene ID" value="PSU_v2.g8796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="113"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8796.t1"/>
        </source>
    </evidence>
    <sequence length="461" mass="53692" checksum="8026DC2F1827CEF2" modified="2023-02-22" version="1">MDVDDYSDNSEGESDYDIDYEMQEEASSPSSSTELQLTVIKSGALVDEMEKTVNEAVAVLGYPSNVCKIVLHTFLWDTNKLFEKFYEAETPEDFFKKYKIDIPKSNETDLVTKKGDCMICFDKKNKLIGLSCQHLFCSECWNSYLLTRFRSEGDPYAKCPDFSCHLYVDDPEKLLNNPEEKAFYRRLLVQSFVNTNPHLQWCPHEKCDKVVKVKSRELGAVTCECGETFCFLCSQEWHEPLTCQLLSRWIKKYSGDSETMKWVSVNTKDCPKCNAAIEKNGGCNHMVCRNKSCGFEFCWFCMQDWKAHGYNNQGCNKFKENTQTDQASKFREQLRRYMHYYDRFANHRKSLQAETDLLIQISLKIEQMQSQLFSWIETEFLRDAVRILNQCRRSLMYAYAFAYYLPSSNEKEIFEENQADLERATEELSGVLEREIENDDIIALKQKVSLTSDVATPTPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAP0</accession>
    <name>A0A914ZAP0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAP0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9731.t1">
        <property type="protein sequence ID" value="PSU_v2.g9731.t1"/>
        <property type="gene ID" value="PSU_v2.g9731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9731.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14333" checksum="4C342D48ED3E3138" modified="2023-02-22" version="1">MIILNTVMLLIELFCGFYTKSVTIIADSFHMISDILALIIALISLKISQRKANSKHTFGWVRAEVLGALVNGVFLLALCLSIFLESLERIYDTQEIEKPWIVLTVGIAGLIVNCIGLFLFHADDIYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAZ8</accession>
    <name>A0A914ZAZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAZ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g909.t1">
        <property type="protein sequence ID" value="PSU_v2.g909.t1"/>
        <property type="gene ID" value="PSU_v2.g909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12797">
        <property type="entry name" value="M23_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="entry name" value="Glucose Permease (Domain IIA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33734">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING GPI-ANCHORED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33734:SF22">
        <property type="entry name" value="MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="Duplicated hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g909.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="30208" checksum="C366B2C1278D26C1" modified="2023-02-22" version="1">MTNAVAASANNAMVQPGETLYGVARRLNVSPNDLMAANNITDPNMLRAGQSLTVPGVKAAGGAMVAAATNSGAQTLGQLKSNGTQAVADAKQAATNKVNNAVASATGGYTVQSGDTLHAIAQRNGVTAAALKQANGMSDGTIRVGQSLVIPASAAAAATQVAAVAKPVQAAVDTTVKTASTPPAAAKQVPDGSVKPYTPPQASNKVIEEAEQDVAMAPSATGISQMRWPVRGKVLTSFGQRDGGVVNDGIDIMVPEGTAVKAAENGVVIYAGDGLKEFARSMLHADRRFVAVKKLPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB02</accession>
    <name>A0A914ZB02_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB02"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8940.t1">
        <property type="protein sequence ID" value="PSU_v2.g8940.t1"/>
        <property type="gene ID" value="PSU_v2.g8940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23312:SF8">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23312">
        <property type="entry name" value="ARMC5 ARMADILLO REPEAT-CONTAINING -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8940.t1"/>
        </source>
    </evidence>
    <sequence length="768" mass="88427" checksum="66A07673DF2A9BD0" modified="2023-02-22" version="1">MAFLNSNGGYYIGALLSQWNFEEIKTKETKVLTLFENFSNFDKRSFGRQIAKSPGEKTLEELLFISDETTVIHKWHKLIIDLLMNAYEFRDAFKRETLDRVVQEYDSSDTKLKLLTVFNQDAWSRNYLRFCGGLKLIMEECSDSFDTKTFFIAKNLSFFMHDSEGLIHICRNDAFLDKILFLLQKYCNETKDKDCPPPESKITLRPDSPNFLQHLEEKRQNMNITNFYVDFADLEASIPAQGSSSPRIRSAWSPSASRTSASPSPSPSPSSSTFSDDESDTAWITHPKKEDIGWYSDSEMDDEQKEMCREKRRDKIVLYLLDVVDWLTHYPENHLQLLRKPVFETLIALSSTELPITAISKACRSIKRLIRSEESLPYLFGLKLHLHIISLIRRPCLMHRYADRCSRCEDRRKFGREVLEELSLQANSGAGWNFMQELLKSDNPDTLFFAFSTALTLIRNVQYRSRLFYFYDILTKLHDALKSILKIAANEGNKFINPDDGNEESNSNLVEDIHTSRVASLKENEPKLEAILFSFASLLSHKMQSAILETQTEPFPLDSTDEICRLENSEIPPEKQIRFKNVNGEILVTADRDSLCAYSEYYRGMFENDFAEKLQGQQDFIFGNEGMYIKDEQFVKFIHLLSGCKKSECVAVDETSTCVSLIYLADKYLATDLLETMFLPTGIAGRFITGSTLSSFVPIILTCLSTHGKFSDLFFFVFLRYASMNEICESLAESLSFSSGDTFCDLFKEFLQRCISSLPIHQSYRLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCC5</accession>
    <name>A0A914ZCC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4005 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9372.t1">
        <property type="protein sequence ID" value="PSU_v2.g9372.t1"/>
        <property type="gene ID" value="PSU_v2.g9372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9372.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17365" checksum="FAA46022C31A5A20" modified="2023-02-22" version="1">MSSSYRRYAPKRDEIPSTSSSSTTRRNLSSTTGEPSTTGTSWASLRFNKPMTDGFRGHSSRLASTFEPSRTTSSSYAPSMASLSSRYSTTSSTTKEKPSAGYVRSALANYQKAVASSDRSTRPKASVAGPLMTYRSQVARDMFKTRFQHQQQQHVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCS1</accession>
    <name>A0A914ZCS1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZCS1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9490.t1">
        <property type="protein sequence ID" value="PSU_v2.g9490.t1"/>
        <property type="gene ID" value="PSU_v2.g9490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037689781" evidence="1">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9490.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18378" checksum="6C0C4043FA95154F" modified="2023-02-22" version="1">MKFGRVFPICVLLFICLQFQISDGVKCSHVAMTGSRDQIDDLLFNATKTKLKEYKGLPGFVHITNGKITCPEACADFWCGTTKETAVFGAGCPQDFYDICSTFSKEITEIQQKGTNDVEYFSRNVFYVSGCGSETDGTKCIKDKQKKAKCFSCLYMHIFAMPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD72</accession>
    <name>A0A914ZD72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZD72"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9894.t1">
        <property type="protein sequence ID" value="PSU_v2.g9894.t1"/>
        <property type="gene ID" value="PSU_v2.g9894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="102"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="302"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9894.t1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39191" checksum="454298163223ECF6" modified="2023-02-22" version="1">MGHGSSHHHNYAYDGSPDQPESNTYRSSIRRHGTNARSTLPPTGHVERPPVIANRRLRERTVNNGRNGTSQVVRVPQRNLIRDRQQSSAHPGNHPSGVTRPWKFDAILARTPPLDQETLEKFAWNPDDRSLNVFVKDDDRLTFHRHPVAQSTDCIRGKVGFSKGFHVWKITWPVRQRGTNAVIGVATKTAPMHLAGYHSLIGQNSESYGWDINRNRCGFDARHESLWKYPTAIPDDGRPFVAPDDIYCILDMDEGFMAFASRDQYYGVAFRGLKGKKLYPVVSCVWGHCEVTMKYLGGCDPEPRQLMEACRNTILGRLENGKDPADVVRLLPLPKSLKNFLLYKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZEX0</accession>
    <name>A0A914ZEX0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BEN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZEX0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8828.t1">
        <property type="protein sequence ID" value="PSU_v2.g8828.t1"/>
        <property type="gene ID" value="PSU_v2.g8828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8828.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34144" checksum="3F25B1126BE7D065" modified="2023-02-22" version="1">MDIFINNHQHHNLHNPLFDAKELQSSLYDDSSNNATTSNFPIIFEQPSNDETPNSEEAVINSGTSNNDAMEFFSLLQSQINDLRAENDQLRTHLKTTDERLIEIEKRLKINRKEIPFDAKFEIARLTLSKIGTFQFFGGPKTVDVASFLRQIAPEEQTFNSKLPRQLFTDCINMILGDSVIYYSYKRSPKEGCCQLDPNLFNCILGLICDGYGLNKDSQKDNEKDKYLRECIAEELNITARKVFKNAADNQKFKSSNQFGIIEPPSSTPQSRPHSNITVSVKAETEPDPPVYCIDSDGDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZHB8</accession>
    <name>A0A914ZHB8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZHB8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9680.t1">
        <property type="protein sequence ID" value="PSU_v2.g9680.t1"/>
        <property type="gene ID" value="PSU_v2.g9680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46895">
        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9680.t1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43041" checksum="B11BE58D20719C01" modified="2023-02-22" version="1">MRMHGTEFEKYLQRYLFPCLAIFGILGNALNLTVLLNRRMRSRANTFLATLAIADVIFLSLLLPNALANYPIFTFNYYFRWFYLHTKVHLLSFANWSSAVAIWCVIAVCADRLIGIRHPLYIRSHVAGYKIKLLIATIVLGPGLFTAYQHVAYKCLVRSYCNGSQLYSRCLPVNQPRWFGNQSNPYSVSFQQFIDISILLNVVLLIICPIILLTALNMLLLCALRQRSHNLLLKGDDMTKPCVDALKHHKTEQRVTLTVALIVTMFTVTNGPSAIVHLLQTVYGSQHENWYNITLFCSALVIFGKASNFILFCLCSKHFRSRLFSLAQKKVHEKLDRRRSSYNMTRKLSYLNPPSRKETPSRSTAVISRASEQSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUM4</accession>
    <name>A0A914XUM4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUM4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10232.t1">
        <property type="protein sequence ID" value="PSU_v2.g10232.t1"/>
        <property type="gene ID" value="PSU_v2.g10232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10232.t1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31922" checksum="82B08D3028544221" modified="2023-02-22" version="1">MLDATTLHKKSNSNKGIKNCIKVTISKTSIDINRQWNILKLKKIISLTFNLDPKQYYLKSNHVSLINESKLVKEYNIVENDEIQIMARGFGGMQKQTSLFTNSKDTIDNSDNFFELNLLTEYNSDHVNVSQNNISITEKVSNRNDNESYVKTDDKSKIQCWNKSSSKDIESMFNNIIPNNDKDDKKEKPELNRSTLSLHIAAYENAIEDILDSNEALETTKLKNKTWKDLKQSSMVVSQNPFEFPRQQHDEKTTDPEVMQFKSSQILLRPDGVCVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVE6</accession>
    <name>A0A914XVE6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10509.t1">
        <property type="protein sequence ID" value="PSU_v2.g10509.t1"/>
        <property type="gene ID" value="PSU_v2.g10509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10509.t1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33282" checksum="A339F88530AC5FE6" modified="2023-02-22" version="1">MPSSTTTDKRLAGFLAKIEHRTIGPSTSKKYWFVLTDDSPFLYWYKNETDISSLGRISLSGAAFVFDPREPTKFEIHSHGEVHILQCTDGKSRSKWLQHLQGNRRKHYERENVDDILNVEVLSITSHSNLTKLGDLSPLNAIDASTLPDSNASSSTMSPIPGPSSVAEFVSDTRFYINADGELNPQSLDIPPPPSPNRDLIKSAEELLFKLADETQSKAHKLEEPAKKAIDRARRSIKLPSFSSNSKTTPCENCKDLTKILEELKDRCYGLTDEVSANQDLVCALRNGIVSAHNQRDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWG9</accession>
    <name>A0A914XWG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWG9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10877.t1">
        <property type="protein sequence ID" value="PSU_v2.g10877.t1"/>
        <property type="gene ID" value="PSU_v2.g10877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10877.t1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39613" checksum="AF64AD1100BE542F" modified="2023-02-22" version="1">MAHKVPLAPSESSTSLSNNLSVLGIQDSSTVDSSELNSSKTEIKQEGLLKEEVVSSPGYLSKPQGVKRRLCKDPIGGSVKKVEKDLADMEEIIRGNKKPKNICLCFKGPASLRKVTTSRGSVLNLTLLDKFGRSVEAVVWPPESTIIEQKLQAFEEDIALEASNDLWVSFPKQPFVFADILHKLNFGPKVIFRCYQLPAGYAASFTKSTPLDLFDLRKKILYHTYKFKIDSMDILEVLSHPKPLSDDLNAVVVGNTDSLAFMKFPKSIEASSMIKFGGNITLKGVHISYDANEIDVDKYWNLFYEESSETKPSHILIISATRSSSIFETDEAATYFVESVSELKHVTPLFLNETFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWJ3</accession>
    <name>A0A914XWJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWJ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11336.t1">
        <property type="protein sequence ID" value="PSU_v2.g11336.t1"/>
        <property type="gene ID" value="PSU_v2.g11336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11336.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33694" checksum="9C39274F778643E9" modified="2023-02-22" version="1">MNNNQGSRIERILLQNKEVFLQNLKTCSINEINIKIDLKFNSLSFLTHSSGGLTQDLCPLAVYPKCMKKIKECFNGFKCLISSQYNVFDKIINFCSDETFTKFNLTFKPAKRPIKTYIDQMNELAKEKIGPIFDSHTTNIPEKYIYTFGNLTFEEFEAVKMISTTIPFLKQYLCDSGLVKEEDVRIVRNFDFVENYLILPESPKLPQKVINIFQTFTAEKYKALKLILMVESILRWSFCSPIFAISPSKELTNIYSQSITLWTLQNCRAMADQNIMTRSAICHGPGLLFGGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWP5</accession>
    <name>A0A914XWP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWP5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10954.t1">
        <property type="protein sequence ID" value="PSU_v2.g10954.t1"/>
        <property type="gene ID" value="PSU_v2.g10954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10954.t1"/>
        </source>
    </evidence>
    <sequence length="130" mass="15456" checksum="34F380B13DE42BC7" modified="2023-02-22" version="1">MRYLLRSFKYQISTIKFNQCEFLITADKLARLINPWKPKSLEFCNCSWNLISEEIETNFDQLFIDFFFSRHQNLDSLIIDFSKMSQQKLEITDKIAQIFNDSTKLPSNLIFKNCLTNITAKTLHNAIWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXY2</accession>
    <name>A0A914XXY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XXY2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1139.t1">
        <property type="protein sequence ID" value="PSU_v2.g1139.t1"/>
        <property type="gene ID" value="PSU_v2.g1139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="56"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1139.t1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45122" checksum="E8F04DDD46160A7B" modified="2023-02-22" version="1">MERNISADFTFLLTSTLTPNVMSSIDFISTIKPSQGVKLNITEATTMPYFPIFEASMIMTIIAFIALVVNLYILNCSRYLRRPIGVNLQLCVSLSASDASCALFYILTYIVPITAFLTLFTVVPGGFRADKAFGFFSNNGCEGGRIFQLLGVRVVIVSPFILFVFIISFLYLHIFIHMKRVSNNPILTSSTSSKTKKTSSRRLLVTIMLLAGSAVIGWLPTLMQYVLFCNECLIHLKPINAFYVGVISQLVNVLKLVVDGFIYASRLVEIRYAMWVFHQQLLSLIPGHKINQYDEIPNEFTRYLSETVENRASRKKDSQRARLAILGKATSQNILRASQNQTTARSCSIIVNNACEKLAHKPLISTNSCAAIVRNHSGGQLSPQTRHKSSDTSATTSCLTVPISDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ36</accession>
    <name>A0A914XZ36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZ36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12475.t1">
        <property type="protein sequence ID" value="PSU_v2.g12475.t1"/>
        <property type="gene ID" value="PSU_v2.g12475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12475.t1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35448" checksum="4A37C9F3F5EF5B56" modified="2023-02-22" version="1">MEASEKPTDVLIKKDDPDIDGDFKNLNINIHFRGADTVPQNSIIPFHRNPSSSSDPEYHKADRKESGVHISPVLPILPEHSGQTPVKSPRKIDPNNDIDIDRLNKIRNYDQAVDATSSDAEFKLIIEVDNSVREPVVDEYLKAKQRQERINLLEKELQPLRGTQFGGGRGRGRAAVVNKGSRSGAVGVDANSGGGGGDLTSHKMYHDIAIIYYKNYELFSQGGSRFPNILQRKEEVWQEINNMLQKNNYTFNVNTIRKNFSNFISKCKEKLRKEDVTGAEPVTFTEAEEYILDFEKKEESLRGIRTSDLGAGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ74</accession>
    <name>A0A914XZ74_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM200 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZ74"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12257.t1">
        <property type="protein sequence ID" value="PSU_v2.g12257.t1"/>
        <property type="gene ID" value="PSU_v2.g12257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018787">
        <property type="entry name" value="DUF2371_TMEM200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815">
        <property type="entry name" value="AGAP005329-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31815:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 200C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12257.t1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11450" checksum="0E81591A7B5C7CA2" modified="2023-02-22" version="1">MQYIGPVCMGFGAFAMIIACVMTLESRDRHAQIIQEESSEYRKLKNKQSDTEGTKTSLLSPFDENLEIIDEVLNANNNSDTKKKVAKENVKSRLFFWEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZP5</accession>
    <name>A0A914XZP5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZP5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12434.t1">
        <property type="protein sequence ID" value="PSU_v2.g12434.t1"/>
        <property type="gene ID" value="PSU_v2.g12434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037434182" evidence="3">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12434.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16137" checksum="E2D7D5A49C32ED88" modified="2023-02-22" version="1">MRAKASLLLGICFLLCVTNLSYAQKLSEEDALEGSANLMSPDDEDFNEHSGELPPEVEEPRKSSTFKPHFVTQPNVNEIIKETVGTDAPTTVITDRPIKDAENADSNHTMLILAIAVIVAVLIVLVLVIACCRKKKSPADYEAGTQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y006</accession>
    <name>A0A914Y006_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y006"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13545.t1">
        <property type="protein sequence ID" value="PSU_v2.g13545.t1"/>
        <property type="gene ID" value="PSU_v2.g13545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005353">
        <property type="term" value="F:fructose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990539">
        <property type="term" value="P:fructose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001511">
        <property type="entry name" value="Solute carrier family 2, facilitated glucose transporter member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="37"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13545.t1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51072" checksum="85DAA01F2368488D" modified="2023-02-22" version="1">MSEVSSEPEQESVSKDVKEQLEPPLKGSLTGLVIWATAVATIGSSFIFGYSIGAVNAPADHIKEWIKINHYEIFGTVLSDDAKGYVFGSAVAIFALGALIGALASGKLADNFGRKGTLHFNNIFAIIGSFLMDYAFYRGFYFIFHLGRFIIGINCGIGSSVVCMFVTEIAPANWRGALGTMQQLLIVIAILFAQILGLKQLLGTATRWPWIFDVALIPAIFQIISLYFVPESPRYTYVIKGDEEKALKDLCLYRNSNENDPMIEREMAEIKKEAEAFKTDAKIGFKDLFRGALFWPTFLACFLQASQQLSGINAAMFYSTEIFKSAGLEDDWPIYATIIMGVTNVFQTTVSFWLVEHRWFGRRLLLLIGTIGMLISTVTLTAAIHVATRGYGDTYKAIGSWSAIGFVMLFVISFATGPGSIPYFYVNEVFASNARATASSLATGTNWTFNFIIALAFLPLQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0G0</accession>
    <name>A0A914Y0G0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0G0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11353.t1">
        <property type="protein sequence ID" value="PSU_v2.g11353.t1"/>
        <property type="gene ID" value="PSU_v2.g11353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11353.t1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36554" checksum="51E9D54C23261039" modified="2023-02-22" version="1">MTYICSLPTFHHFRIGDRKFALSFGSDYSASKFHNKIQKALSHLSRQSKSTIAGSGDSNLDTSDDLDDDVFATDSIETPSIIRQWPQKSILARHVIAPVCPAVSVTNHLNEEIDFYAEDDLAMPLCPMRPTNLTNLTNSINANTVSPQHDSGDGPPMDPEYARGNISDVLSLATPKLVQSSSSGATSAQEKALRFAKMRSIRSSSNPGSIMLIQKLSAKNSRDNEISKSKSLLESHLRSSYNTKEAAYSLRNASFELVQREFCFYCNQWYNVKDNKKGACPEAPDAIEKFIKKYTLYSWASKFVNKKLQTRQNDPCTPVRILILIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0G6</accession>
    <name>A0A914Y0G6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0G6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12278.t1">
        <property type="protein sequence ID" value="PSU_v2.g12278.t1"/>
        <property type="gene ID" value="PSU_v2.g12278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12278.t1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13610" checksum="0F77205D26BC3D25" modified="2023-02-22" version="1">MELNNPMLCEANKCPTLSGAKFNGVISPLFSSPQTLTCDDATMQYTFIDGGGMEQQISAIECVCKLESCVMPTITGIDSNPPLYDPAAIPYIYPNGKCQYSHVLTCQNPLATTMEVCFFSQRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y105</accession>
    <name>A0A914Y105_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y105"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12467.t1">
        <property type="protein sequence ID" value="PSU_v2.g12467.t1"/>
        <property type="gene ID" value="PSU_v2.g12467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12467.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12826" checksum="96D736B86AD06559" modified="2023-02-22" version="1">MLLRDPKNADPYDYQVWKFDRNVPSSSLQEEDYDVLKVLDIEEHYKLFISKPPPFPQSLTTLSAEEMTQLSNELGFVNDAEILAHEQRYFPDDNNLSFDALVRPDIAFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1U4</accession>
    <name>A0A914Y1U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1U4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13204.t1">
        <property type="protein sequence ID" value="PSU_v2.g13204.t1"/>
        <property type="gene ID" value="PSU_v2.g13204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037571357" evidence="1">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13204.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="28619" checksum="4E80DF5B88440C0F" modified="2023-02-22" version="1">MKLLLLIGAFCVAFTFAQETTPENGTDPKVKNIRRQVPAYAAALYAAPPPVFAAPPPPPQPLFAAPAGYAYPAPAPIPLAPGPAFLPPPPPPMPAYQPPPPPQCAPACIGNAACVSGACACSAPIAYSPVIGCAPLPPPPPPPPVPVVTGRLIPQALPGAPCEPGVECTGGSVCSMGICLCPPELVQEGTVCVSRTIYGIVPPPPPPPVFIPAPVPVYAAPAPVALAPGAPCFSAPSPCSPGAFCDPSAGVCRCGPAYAPYGGACVRRKLARKEATSEEKPEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y210</accession>
    <name>A0A914Y210_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y210"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12818.t1">
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        <location>
            <begin position="47"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="114"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
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            <begin position="44"/>
            <end position="241"/>
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            <dbReference type="Proteomes" id="UP000887577"/>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12818.t1"/>
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    <sequence length="241" mass="26152" checksum="38D48D30AE8958CC" modified="2023-02-22" version="1">MGHYSKTEPSVSLESDIKTLNVAEIDNISASSSEVQKPQTDWRSIHVAATVTYVGAVQFSLYAASMFPYLQVLDKTSTENFFGVIIAVYSLGQIISSPLYGYWSNKSHNTKSCLYYGLATMFFGNILYFFAGIIPFQKKYVILVARFVTGFGSSNISLLKAYATSASTGADRSKAIAYVTGGIALGMLTGPGLQLFFTPLGPNGIKLKETGVALPPIDTVAIVVCYVTRFCQMFIISNLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <begin position="1"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13655.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32773" checksum="FA601E4964FDA4DD" modified="2023-02-22" version="1">MSTPSSSKRNDDVSDFIEPTNGFEEDDMLTPADNQHQFLESENFEQELGTTGLEDPFSENFSDIARHNIVEVHSQGDLVARPIIVVYAYRLPPNKEFDHQKFLRYLQHTLDKFVDLDYSIVYCHYGLRSNNKPPLKWLIQAYQVLDRRYKKNLKALFLVHPSTFIRIVWNIFKPFISLKFERKVHYVNYLHELNTYIRIAQLNLPQVIIDHDMSLVSTSKTFFGRTPPPLPPRPTQQFNVSLDFILENHPDYMVPPLVVSLIEFLRNYGLEVCHTFLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y317</accession>
    <name>A0A914Y317_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Gustatory receptor</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
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        </lineage>
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        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="PSU_v2.g13633.t1"/>
        <property type="gene ID" value="PSU_v2.g13633"/>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13633.t1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26296" checksum="E1D69B43C1625DB3" modified="2023-02-22" version="1">MNFGVVKVPQLFIMMISIKVALMFRINATILSKALARTKAFPIRETLENYFEQLLDIIKVLNMLECCFNKLMLAIVATSVIKVIFTGYATIRELLYNEKFDNIGMKSIFLDNDQEFENQDGYLPYLITLDSICSVFSVILNASWTVIFLVPCIYCNEFSRSALPVITSKLVCDDAKNVKDQIVQKLMDSSWNLTLGKLVVVDRTFAMTLISLICSVVVVWVQFPTTVSLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3Z4</accession>
    <name>A0A914Y3Z4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y3Z4"/>
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        <property type="protein sequence ID" value="PSU_v2.g13950.t1"/>
        <property type="gene ID" value="PSU_v2.g13950"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="16"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13950.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="37691" checksum="BC1232468C811651" modified="2023-02-22" version="1">MSVPKTQKAQVCTSLRVDPIYRTDFPVPEPKPHELLVHVLFSGVCHSDVSIVTGDIPMADYIPLPVILGHEGAGIVAKIGENVKGFKEGDRVGIMMTLESCFECESCKSANEHYCDKLKLAAIHSHGTFQEYAVVSAAHAHKLPDGIDLAKAAPLHCAGVTVYRALKQSGVRAGEIIAISGAAGGLGSFAIQFAKAMGMQVLAIDVGTIKEEHCKKLGADYFVDACNSELVKHVTEITKGGPHGMINVATATKPIEDAMLYVRKRGTIVAVGLPKNPNFTANSYVLVQRAITLKGSFIGNRKDMDEVIEFFARGLIDVPIEVHGLSELPKLLKKLQKNEVQGRLVVDTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4X1</accession>
    <name>A0A914Y4X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrator complex subunit 5 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4X1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13822.t1">
        <property type="protein sequence ID" value="PSU_v2.g13822.t1"/>
        <property type="gene ID" value="PSU_v2.g13822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13822.t1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28926" checksum="FB2B661DCB6F6322" modified="2023-02-22" version="1">MLAQLILQCLEVNEFGEQRCKLLHCFCIISDISFVRRVFAAFIYATENSEQLLQFTSFASTVALHFPSAMLEGLKELVKRPNIYISMFNDKRQRFQTFYNIMTLLKWAKETAENSGIQTSMFGLRYDQFVDTISIAELGGLLIRFGVSSLAVFLESLETMNEELYDKFTIAIEFIEEIDGAAPMEPGMSFTISNYLSVVYVHCLRLIKIDDNPRYGTVAVLKLNKLVKHILSQKWAFSKNRFVSTLVKEVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y519</accession>
    <name>A0A914Y519_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y519"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12796.t1">
        <property type="protein sequence ID" value="PSU_v2.g12796.t1"/>
        <property type="gene ID" value="PSU_v2.g12796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12796.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21235" checksum="E3444F3B1891BB10" modified="2023-02-22" version="1">MVSFTCGTCNEVMKKNQVRKHLTRCRTRHVACLDCNVDFNIAQYDEHRKCITEEQKYQGSTYQPKVNKGEIKQAGWAALVGKAKQNAKDPRVKKLLDQIEGFDNVPRKKPKFVNFVSNCARCRDKEVAEKTFDLIKAVETEEKSAVAVPVKPIEDATEQPAKEIAEEVVEEVAEKPVVKKKKTKVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5E2</accession>
    <name>A0A914Y5E2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5E2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14459.t1">
        <property type="protein sequence ID" value="PSU_v2.g14459.t1"/>
        <property type="gene ID" value="PSU_v2.g14459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052763">
        <property type="entry name" value="DnaJ_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14459.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="23010" checksum="6444ED06F9957FA1" modified="2023-02-22" version="1">MNKALLSSTVHLSRLSTIRCVSYVPRKRNYYEVLGIEKTATLDEIKHAFAAESRKLHPDSRDAKTAAHNSTEKFMELKEAYDFLRKPQKRIEYDRELEFSRKVSREMFYENPGSDYETINLNVRGPGGGLHRSPPIKSSRFGHFFDPTKEMEREKQNDRFWWTFGAAVLLIILGNIFYVSFFMKKKKKIDRELTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5I7</accession>
    <name>A0A914Y5I7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5I7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14700.t1">
        <property type="protein sequence ID" value="PSU_v2.g14700.t1"/>
        <property type="gene ID" value="PSU_v2.g14700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="289"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14700.t1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47367" checksum="6BF8ACC1733A9438" modified="2023-02-22" version="1">MFIQNAIKQKHIPLALGEKGIHQNNMDSLIRTLASFQDSVYDNLEINPTLQEYLSNIHIDREHIRAEEDKLYNLSLFQEPQETPSTPRNSSLTRLSHFSWKLTRSSTPRLEIPTTSKEPFKVDPFLKTKSLTPNLSLLKGPSKFKKGHKKTFSHGDETTLGIDNSAFILASTSTEAANLTADSLDNFLDQSCFETSPQNHIPEITDDHLLDSSYTAESPMRRARKDSDSPDCLCNGFDALKLTRNTPRSSSVFGRRKDPRRPPILPVERKGSLSNFATDKILLNGTHLADIQGMLYRSTVRRSKNKPVLLRYSQRIWVELHQQYFFEFERKTIVFHHTCERYLYRSTPRRIINLKDSSWKVIRSFVSSDTFELHHSQTGAIVVYRCQNSHAANEWSSILSCANHQDEDAMVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5P9</accession>
    <name>A0A914Y5P9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5P9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15524.t1">
        <property type="protein sequence ID" value="PSU_v2.g15524.t1"/>
        <property type="gene ID" value="PSU_v2.g15524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15524.t1"/>
        </source>
    </evidence>
    <sequence length="565" mass="64593" checksum="7E5D462A28A5184E" modified="2023-02-22" version="1">MNTLIATQQYVHEMTRLSGPGMKVLLMDKETTSMVSCAFAQSEMMAREVYLFERLDTGAEREPLKFLKCLVFVRPTLENIQILTEELRAPKYAQYYLYFSNIISKADLKILAEADEFEAVREVHEFYIDAIPLSPYLTVLAMPLCYETPFNLSGGNFRRCAQALLALALQFKKKPAIRFQKSSRDAQRLADEFVKMTVREDKLFEACRNDTVIVIMDRSEDPVSPLLNQWTYEAMVHELIGMNNNRVNMTNVPDEGIKNIVLSAQHDDFYAKNRYLNFGEIGQNIKSLMNDYQKKAQTHQQLESIADMKKFVDQYPQFKKIAGTVAKHVQLVGELSRLVGAQNLLEISELEQTIVATGDHSQCFDRLKRLLKHEKTTDLNALRLTMLYALRFEGSSSNSLPALLEILRQRKMSIRQVESVNTLLRYAGARKRQNDLFGNKSAVEMTKRFIKGLKGVENVYTQHEPYIMQILEQLHKGKLSEIIFGASELNTLNTHYDNVIIFIIGGATFEESTFIHLYNERRLTNPGLPRVVLSSTSVHNTKTFIEQLIQLTPDSQAVPPFASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5U4</accession>
    <name>A0A914Y5U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y5U4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14610.t1">
        <property type="protein sequence ID" value="PSU_v2.g14610.t1"/>
        <property type="gene ID" value="PSU_v2.g14610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17748">
        <property type="entry name" value="BRCT_DNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000006">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000007">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000012">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005932">
        <property type="entry name" value="PRK07956.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF9">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="OB_DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="272"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14610.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="37705" checksum="FE13BD9B087E2DB1" modified="2023-02-22" version="1">MTRVESIEFQVGRTGVVTPVARLKPVFVGGVTVTNATLHNEDEVRRKDVRAGDTVVVRRAGDVIPEVVAVVLEQRPESSVPFEMVKECPACQSALERLEGESAWRCTGGLICPAQRKQTLIHAASRKALDIEGLGEKLVDQLVETGLVHTLADIFKLQVEKLVLLERMGRKSAENLIEAIDKVREPALNRLIYALGIRHVGETTARDLAQHFGSLQALEQADEEALLQVNEVGPVVAASVRHFFQEPHNREALDALLAAGVTPQQAQARANSANLPLAGKTVVITGTLPSMSRDEATRRVLEAGGKASGSVSKKTAYVLAGAEAGSKLTKAQELGVTILDEAQFLALLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y682</accession>
    <name>A0A914Y682_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y682"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13161.t1">
        <property type="protein sequence ID" value="PSU_v2.g13161.t1"/>
        <property type="gene ID" value="PSU_v2.g13161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13161.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="9927" checksum="9A0DD38BEB5C2B99" modified="2023-02-22" version="1">MHFFGIYLVAAEDTDLKSLPTNKNDPKPTNNNNNKEPAAPPPAPEEVKPQSAMIQAGNDNKFISKGNGVFVDKDGNPISQLAQPPQKDDAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y687</accession>
    <name>A0A914Y687_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y687"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13166.t1">
        <property type="protein sequence ID" value="PSU_v2.g13166.t1"/>
        <property type="gene ID" value="PSU_v2.g13166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13166.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14740" checksum="DD9BD595C4D5A3C6" modified="2023-02-22" version="1">MFFPSFEDSKFDEIFPHHSEAKKSLISTTSEAAAAEMDSEMPVKPNPDAIKTNDNDNNDMASKPMKNNNIETIFGAKRVALMKEKRQFGGENFMNPRINKLFMNYEAALPNYKKFDYSNFLQSHSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6F0</accession>
    <name>A0A914Y6F0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MYND-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6F0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1577.t1">
        <property type="protein sequence ID" value="PSU_v2.g1577.t1"/>
        <property type="gene ID" value="PSU_v2.g1577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1577.t1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21828" checksum="BB86A705CF5A6C39" modified="2023-02-22" version="1">MLRKSSSETVQNVPHKPAPPNWPLTKTKKITGRDMDPTKDKVYNGCLLNGRIIDWAFLMSSIATNIEDENGQIHRFVINKWPLPSLRDFAILEAVKVFRPNVKTSIINPYHRKARDGYNTIRVEGPEYVKLDTSMIDEQCHVCGKEGKALPSCSQCKMALYCSKECQTFDWTEFNHKGICKYLKMFSQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6P4</accession>
    <name>A0A914Y6P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6P4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15870.t1">
        <property type="protein sequence ID" value="PSU_v2.g15870.t1"/>
        <property type="gene ID" value="PSU_v2.g15870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15870.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20896" checksum="89A4249B555A3687" modified="2023-02-22" version="1">MSSTILEIVNQLLAIKEKCGNIHKSWKDAVQRFENTKVHIPLERTVYLQEVGHYKILLGQEHSKMVDLERLLRDAAAKERLEVGRLLKETTEELIKKNRYFPSPLVIMHKPKRRYNEEEEFYQPFLDEVIQTEPAAKKSKKEEKKEESKVAAANITTSTEEKEEKKEESEEMEAGANKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y829</accession>
    <name>A0A914Y829_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic binding protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y829"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14906.t1">
        <property type="protein sequence ID" value="PSU_v2.g14906.t1"/>
        <property type="gene ID" value="PSU_v2.g14906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050555">
        <property type="entry name" value="Bact_Solute-Bind_Prot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30036">
        <property type="entry name" value="D-XYLOSE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30036:SF1">
        <property type="entry name" value="D-XYLOSE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037042786" evidence="3">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Periplasmic binding protein" evidence="4">
        <location>
            <begin position="40"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14906.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16777" checksum="5051F5ECB87B33C8" modified="2023-02-22" version="1">MKIKNILLTLCTSLLLTNVAAHAKEVKIGMAIDDLRLERWQKDRDIFVKKAESLGAKVFVQSANGNEETQMSQIENMINRGVDVLVIIPYNGQVLSNVVKEAKQEGIKVLAYDRMINDADIDFYISFFRYEKSVTAGKSPGRYCSAGITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y840</accession>
    <name>A0A914Y840_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase type 11 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y840"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15614.t1">
        <property type="protein sequence ID" value="PSU_v2.g15614.t1"/>
        <property type="gene ID" value="PSU_v2.g15614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF59">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15614.t1"/>
        </source>
    </evidence>
    <sequence length="679" mass="77352" checksum="BFAF4A3520EE3506" modified="2023-02-22" version="1">MAKMLSSPDDFADPQFWEKLYKSGRKIDWYGNIQKYIPTIRNMVKKDHKILQIGCGNALSEYCLYDNGYQYIHSIDIDERLINERIKDNETMVRPGLTFACEDATKLTADDNTYDFVFDKGTLDAFLPSVKTETGLATKMFDEALRVLKPNSKYIIITLAQTHIVEFVSSYYKNRNDIFLYFYAVDIPDEKGDSIPAAIIQFHKLKQAMPASLPKVIKFVIDPVTPVTVNVTTPEMIRYFEEYRNLALFTNQCRRPLQHVPRITLQDQTTKQARWTFYACDQTPNPVKWAFMIIPAGHGFTLDDEIVASFAAQTSYDRVIVAEQQPDCDYSDLEKVRLELESVSFRFRPINGEEQAEIAWCYGNNDTHESKVDSGEAPILGAYGVYNLSAGLEVNNKVIRRLVFENSPEIVQTDVLVYPAKKNDKIYKKVDVLHLSGLYQMMMLASMEFRSGGLPESLKKDYNFAVLGVAGGTLVSFLHNVFKQSKITAVELIPELYGVARKWFGYPNDDDRLTSIGRDALEWVKDDTAGTYDFLFVDVSGTKDGVTTCPGVEFIDPEFIPLYKKRLAKHGMVVVNVVSTDTQFVDHVTSAFSEHFKFISLGRPGDPTNEILLASDTQFARPRNYNVARRSALPSELSDIYDMVALYKPYVEKKVTQENDFLPSHLLNQNGKKKNNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9I7</accession>
    <name>A0A914Y9I7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9I7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16099.t1">
        <property type="protein sequence ID" value="PSU_v2.g16099.t1"/>
        <property type="gene ID" value="PSU_v2.g16099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16099.t1"/>
        </source>
    </evidence>
    <sequence length="770" mass="85333" checksum="3DE39D8A12037C19" modified="2023-02-22" version="1">MIPETLVVDMEIHLGTSIGWLFDQVQTQSENVEHLSNEKQRLEDEIEALAEDKSQLLAQLAKERGTHPGLSTIELRQLELLGIKDVKELINQVRFLQVKVAQLEADKSRGLLKAQASVSTATTQSQSTWPPVQGGLRFSTLGGKYQHDSLMQRKACYSEVKRELLNALGSDSSAATYSMRTSLDKLIKPSGKSYRMILEEIEQKVAEAFGDDQGQREQELKKILLRLTQEDPDTTYCNITLPYTAASYYRLKELVLGTEDANKLRKQNSDLKQSVERKQPVKAFQPVRVAQRYPPSLNTVPPRNSVNDTAAPQRPPGFEQTKDSVAPPGFGQQKMPSFVRQTEGNQGRVQQGQRFAPKCYECHGYGHFAKDCSVRGEAHVVEEGDDCDQLEFTVSGIVPINVVSSSDPVKLFGEKTLLETRFDGIKVVSMLDSGACVSVISDTVLKGILRDKSRQGKITRERPETYKGSGLVGANGSKLNVVDCVRIPISWGEYEPSPAIFFVVAGLQQDVLIGTNVLKGNPTWLHALEYALEAKAEFQRKRGSGAKAGKDRVQAEHQAGAFVGVIGWNVTAAEHVVIQPKTLKMLKVRTPFSKTLSLIESSKPGIETGVVRSRRGKAWVEYRNYTDETQVIHKNEVIGEAWPVRLGSATDGRESDNPVNIIADCQERVKKLKEQLNLQTTGLSAEGKLQLVELLEKYHEAFAVTDDEFGLTNVTEHSIDTGDARPIKQPARPVPIPLKPQVREMVDTMLKQKVISPSSSAWNSPVVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9M1</accession>
    <name>A0A914Y9M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9M1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15463.t1">
        <property type="protein sequence ID" value="PSU_v2.g15463.t1"/>
        <property type="gene ID" value="PSU_v2.g15463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="228"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15463.t1"/>
        </source>
    </evidence>
    <sequence length="334" mass="39735" checksum="334054D3DDC74704" modified="2023-02-22" version="1">MISVNILTELPEGEWFCATCKKEGKDVYEDPNDSDKKNNDTCTICKEGKNLLNCESCINSYHAYCLNPPLEEVPAEGEWNCPKCILPDPGKKAEKIMSWRYIEIKYPDPISEDEKPKDGEEATEEQQDAQILKPPKQMPPRREKEFFIKWKFMSYWHCTWVSELMMDTYFPQLLRMYWRKFDPETPPEVDDGSNEDVQTGEIEGKEKEDDPHNLEEKFYRYGIKPEWMQVNRVLHHICYQKGQYDYLVKWKELMYDQATWERDDQEIPGYEEQIFKYWLHRERMTGESVPKAIVKKINAYAAEHGGQKYDEDDMKKKRKKAAEKATINVRILMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9U8</accession>
    <name>A0A914Y9U8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9U8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16992.t1">
        <property type="protein sequence ID" value="PSU_v2.g16992.t1"/>
        <property type="gene ID" value="PSU_v2.g16992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052501">
        <property type="entry name" value="Alpha-1-2_FucT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22898:SF3">
        <property type="entry name" value="ALPHA-1,2-FUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22898">
        <property type="entry name" value="UNCHARACTERIZED GLYCOSOL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16992.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24738" checksum="6C665FFAE858507C" modified="2023-02-22" version="1">MLFRFASLYGIGKNLGRIPYVNASIHLQVQGLTEISEYFPLLHEYVEVKIPHESLVTVANFSDVCCIYETPKNLEKYNNVKYLKLSANYLQSYKFFHHFQMDIKKLLECSNSFKQKADMIADKIWKTDKFSHKLCVHVRRGDFFYEPWPLETRMDFVNPALEHIYDRLKDGLINDISLLIIGNDKNFISNMSFPKLVNFIPIEKLICRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA19</accession>
    <name>A0A914YA19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14369.t1">
        <property type="protein sequence ID" value="PSU_v2.g14369.t1"/>
        <property type="gene ID" value="PSU_v2.g14369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14369.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9335" checksum="0629FE28A3D904A5" modified="2023-02-22" version="1">MKEKKRKKEQDFLTKTLDVPVPAQKKNHQHQQLQPSNQQILQSNPPKWSSNGSTGSLSDGGGSSTCSLSTPESSPKLGELLYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA70</accession>
    <name>A0A914YA70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YA70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15663.t1">
        <property type="protein sequence ID" value="PSU_v2.g15663.t1"/>
        <property type="gene ID" value="PSU_v2.g15663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037009922" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15663.t1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8153" checksum="2A4C88DAD6BE852B" modified="2023-02-22" version="1">MNANFFILVAFFAIVTCIFAGDQLNLTSNQEDSELSQGLRVKRGWLCWDGMVKACCNNKCKGDGCVGLMCDMCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAE8</accession>
    <name>A0A914YAE8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M1 membrane alanine aminopeptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAE8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16406.t1">
        <property type="protein sequence ID" value="PSU_v2.g16406.t1"/>
        <property type="gene ID" value="PSU_v2.g16406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF301">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16406.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12812" checksum="E605F0F16B74179F" modified="2023-02-22" version="1">MSSYLLALCVSDFEYVEGSTDKGTRFRIWSRKEALEETEFALYAGIKVLTFFENYYDMMAFPDFAAGAMENWGLVTYRERVLLFNEKLYTPLQKQYVATVVAHELVSVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBA8</accession>
    <name>A0A914YBA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reduced folate carrier</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBA8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16047.t1">
        <property type="protein sequence ID" value="PSU_v2.g16047.t1"/>
        <property type="gene ID" value="PSU_v2.g16047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16047.t1"/>
        </source>
    </evidence>
    <sequence length="556" mass="63073" checksum="78100DA90A46B231" modified="2023-02-22" version="1">MGAEEHRLSVVSARIRNVKKMNFAYMLPIFLCIYSIVKEIKVGEPFMYKYQTEYLNLTATQLTSEIYPFYPYAYMLILIPIFLLTDLFLYKPTMLAEVLGQIGFRFSLVFTYDVFSQQLGQVAYGIASASEVAFFSYIYAKLEKDQYRKLTSWTRAGTMGGRTCGYLLSQLIILGGLGTYRTLNEIAFVIPCIVLVACIFLPRVHWKVMVARMSEGRSRIINSKPVTKKQRPLPTTYSEYIIYRTRKLKSDFIKIYSIGFIRKWSFWWAMTTCMSLQVAQYAQTLWGEVQIDKHSPLNGFAEAGYTFTSTFAILALNAIPINWDKWGEVALVLISSIDAGVLLLYSQTGNIYVMYGCYIAYRSLYQVMITIAQWNIAKKMVCESYGLVFGANSFIALIMQSLIMFIVADKRGLAMPVRQQYVIYAGLHFLIAVIFSISVAYTVATFFCRKTKIVDQTSPTKTTSSTIGNESDATEIIERRASRKASTRTTEPLELQVKNIEQDVENHSQISPEFNDLENDFESDDDILVSDDELPTFSSSIAGTMAASFSASMSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBV8</accession>
    <name>A0A914YBV8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ubiquitin-related modifier</fullName>
            <shortName evidence="6">SUMO</shortName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ubiquitin family. SUMO subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16906.t1">
        <property type="protein sequence ID" value="PSU_v2.g16906.t1"/>
        <property type="gene ID" value="PSU_v2.g16906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd16114">
        <property type="entry name" value="Ubl_SUMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000280">
        <property type="entry name" value="Small ubiquitin-related modifier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046332">
        <property type="entry name" value="SUMO1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16906.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11115" checksum="4B1E61079280D57B" modified="2023-02-22" version="1">MSDNEQQQAAPSGDGGNQAQDYIKLKVVGQDSNEVHFRVKYGTSMAKLKKSYAERTGVNINSLRFLFDGRRIGDEDTPKTLEMEEDDVIEVYQEQLGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBY6</accession>
    <name>A0A914YBY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16272.t1">
        <property type="protein sequence ID" value="PSU_v2.g16272.t1"/>
        <property type="gene ID" value="PSU_v2.g16272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16272.t1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12553" checksum="21A98A0EDB46FF2F" modified="2023-02-22" version="1">MLLDEIDSEKQKSVPINAQPNIAAKTGKGAKVVTGSADDWPALHANNVHDNAQDSGNITSNDVITGNSNSSIAQTNNVVRDSSEHNSPNGMRNQKVPKNNWKKLDIEVDYNHRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCX6</accession>
    <name>A0A914YCX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of epidermal growth factor receptor (EGFR) signaling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lst-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCX6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17145.t1">
        <property type="protein sequence ID" value="PSU_v2.g17145.t1"/>
        <property type="gene ID" value="PSU_v2.g17145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15731">
        <property type="entry name" value="FYVE_LST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043269">
        <property type="entry name" value="FYVE_LST2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051118">
        <property type="entry name" value="LST-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46465:SF2">
        <property type="entry name" value="LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="460"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17145.t1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61500" checksum="611E6E77F08B8E0F" modified="2023-02-22" version="1">MVDPSSVSNTMFGKTMYGLRKLVNKPRVDDWSPMAKFFHADEALNRIARELDSFDGRRDPDRCNVLVTKLRQAQDRVLLIISEMLVTIYPLESERANRDFRAKFPDEVIHENLAGQLWFGAECLAAGSNIVGREAESERLRPLARALTKHLDSMREMLKDQALKDPSQYPDKLKESLFYFDHLFANFEFDYVSVMVEVKSVKEYDSQQDVAVLFSEATIKAQKMGYITQEQIEYADPVMMIGLPRLAVLWALLYYPDSIKLDSSPDEMSVLFRHFQNSLIQCRSVLKVMKGFAIKELEKRLLSGNGCGDTSIEGVEKTVMDLSGNHTEQEPTLNDSGNVSDETFDKPAENQEDSGSLNDECQMEVILKGCSESKVVNVRIEDLIQFLFKRISAVSDQLQTNFSQEFRKIMKSVMRPVSDMRAYEFPGQVSHTEAVEEETGVEVQESMPLRATVGVRWVPDNDCLQCTSCGNAFTVFRRRHHCRNCGRLFCSRCSSNEMPIPELGYDSNVRVCNLCYLYKVNPFTPPIPNSEISTSSSPDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEW1</accession>
    <name>A0A914YEW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase FkbM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEW1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1729.t1">
        <property type="protein sequence ID" value="PSU_v2.g1729.t1"/>
        <property type="gene ID" value="PSU_v2.g1729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989:SF3">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989">
        <property type="entry name" value="UNCHARACTERIZED DUF13 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1729.t1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14822" checksum="D2956239B6AD6D3F" modified="2023-02-22" version="1">MKVVELTKLLDEFVESRFIHYLTIDIEGFEYGILRELIGNGQFAKAGITICQIDAELHNPKFPNAHDSIKQLNPVRFILDFLDTPSPYIPIFNVPYLKHPHQKVSFVNIVNPECRRAFKIESYFDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGD5</accession>
    <name>A0A914YGD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGD5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19363.t1">
        <property type="protein sequence ID" value="PSU_v2.g19363.t1"/>
        <property type="gene ID" value="PSU_v2.g19363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ground-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19363.t1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17746" checksum="E565F455907A5CDF" modified="2023-02-22" version="1">MPAPPSVSPPISQLGSYPLSTFGPLPPPRDEAMTQESPCDGCENNNFSPGGGGDQWLLGDNSNGILENNEKCNSLRLRYIIQESIVNSDAEASKRAIQLRAETELNSFFNVVCGTGFFSYIAHTDEFCQASAMGINCYVFSPVCSVRMPPQMGSGVARKKISSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGI9</accession>
    <name>A0A914YGI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16454.t1">
        <property type="protein sequence ID" value="PSU_v2.g16454.t1"/>
        <property type="gene ID" value="PSU_v2.g16454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16454.t1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23135" checksum="5A747B8908AA10DC" modified="2023-02-22" version="1">MTITRASVDSTPAPTVTEIPIPNLAPRGLKPFPPVKHLFDFEVREPYIIGRNAHDIGNGLDIYFEDFEHLVQKDSLNVIETATSENFWNNVNRPELVENEEGLFVCPEEPCIGTFVNNSDLQSHLHIGIHIFSKGNQADYAMKRFKKRLEEMVSDQSTLSRDNVVHIALSQFSGAENVLAHYPRGWALVEEKKTVSVLPKIKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH66</accession>
    <name>A0A914YH66_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH66"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16646.t1">
        <property type="protein sequence ID" value="PSU_v2.g16646.t1"/>
        <property type="gene ID" value="PSU_v2.g16646"/>
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    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16646.t1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37329" checksum="DDBB2CF6F5078C94" modified="2023-02-22" version="1">MSILAEPRRKRKICLDPQNLAWKNDTNKFGHKMLQNMGWNEGQGLGLKNQGMTENIKLKANYTQKGIGAEASDADRTWIAHHDEFSFLLEKLNATKAAKVAEKEKVAESEDSGDSDEEKEAPKSKKLRGDSSKSLEEKSKATKTRIHYKYTKMKDISRYSEKDKSAVIGVGLKSKIVEQESKKEKNTAEKTFEEPATVKNSAVSVTDYFAAKMAKFYAKKNGTTELKSEIPQVKEEKVEIIEEEIVISEEVFGNEAEEKLRQKAEKKALKKAKREAEEALTENIKVEKVSEKIEEDEEEERRRRKAERKEQRRKERELQALAAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHD5</accession>
    <name>A0A914YHD5_9BILA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
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            <taxon>Rhabditida</taxon>
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            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHD5"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
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            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18879.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="8310" checksum="9A2F242349BD074C" modified="2023-02-22" version="1">MGDQYEPIVNMGNPPPPPGDNQYEVPVFAGNAPPPPPPPPPPPPPAASPSYPPPSTPSADAGGKSEVKSEAKSGKSGKSGSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19862.t1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8556" checksum="7CEDE8D5626C78A9" modified="2023-02-22" version="1">MASTPKEKSKIPFRSFLGRIFNNANNGNEPESLKSSSSNPVIGHPYNTVHKLHVGFDGSDFSGLPQEWLKVLQRDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHX3</accession>
    <name>A0A914YHX3_9BILA</name>
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        <submittedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1892.t1">
        <property type="protein sequence ID" value="PSU_v2.g1892.t1"/>
        <property type="gene ID" value="PSU_v2.g1892"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
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        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
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            <begin position="329"/>
            <end position="339"/>
        </location>
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            <begin position="670"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1892.t1"/>
        </source>
    </evidence>
    <sequence length="688" mass="78371" checksum="C3F1B7360D0A1653" modified="2023-02-22" version="1">MEYYRPMASQYLQPQRQHVSYSPNKQTNGTQQVPATSMYTTSSGFQTFQTVLTPTYTDANGEHVTKIEPHDGEHQQLRVLMPVYQNATSSGTQIKFVDASGAGNSVIFSTSNGSYAQNGTIVHHQQQQPQQYQTIQIANHQHGQIGHQIVNGQLINSSNGQQHFSNPVQYIVVQSTPNGNTVPVEIKSEIDPPMVITQSQDGVNVRRAKDANRKRRRRLTESEEEAMARRQKNLEAKRRRLARETDDERRRRRQRDAEAKRKRRERETEEQRLSRLKRDSERMRRTRRLKNFRLQNKDGVPDEIIQAESHQQHQQSQQPTHSRSSHQQNNQHAVTVSNSMPPPTRIVHHPKQEPTSYLSSNSSAAINQTIAAVVDNKHSNMVVLDQKPLPQGAFISTGHPHTIQIPANSMVQTVQVPQGMLIPSSQGGGVQQIILLPPSGQPTNAITIPPGTQIIHQRHADSSASSVSSSFITEAVQQQHPQQHQSNIILPDDPTERQRIRNKERARRRRALETPEQRAMRNMKTAERMRRRRAQLAEQRALEHGHSQPIKVNLTDEEYNHRFDDIFECVLKRADYEVENNGPICPRPKFPPGYHQPQPEQIFVEENPESFVLEHMDSSGLQTDGEEQEYKPSLDEDGNTNGVDESSHHDGSLHGSSISHDDLDDEEDISQDHDDDNHVDHDEMLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJD6</accession>
    <name>A0A914YJD6_9BILA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19622.t1">
        <property type="protein sequence ID" value="PSU_v2.g19622.t1"/>
        <property type="gene ID" value="PSU_v2.g19622"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19622.t1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11279" checksum="316C8AF6F2043C0F" modified="2023-02-22" version="1">MLMAKSYQGDMSSNAVEYKKLTKLPRFMKLQKFTFRHLSPYFNVLNFTGFIKTNPNVSFVFKYNYVFYDGKNNIRTREAELRKSLPPNCNVVVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJP5</accession>
    <name>A0A914YJP5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-disulfide reductase</fullName>
            <ecNumber evidence="1">1.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleoredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YJP5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19743.t1">
        <property type="protein sequence ID" value="PSU_v2.g19743.t1"/>
        <property type="gene ID" value="PSU_v2.g19743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02964">
        <property type="entry name" value="TryX_like_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052259">
        <property type="entry name" value="Nucleoredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871:SF18">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19743.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19152" checksum="9B498CA4F4F06F3B" modified="2023-02-22" version="1">MLAPLLRPQGIFQFARYASTCSSSGKHFLGSVPLKRGDESADASKLSGKPLVLYFSAGWCRSCKMFTPKIREFYENYKGNDLNIVWISRDRSAEDQLEYYKKSMPDWHYVPYGDEIQNLLKKYDVKTIPAVKVVNDNGEVIDDGARMKIEKGETSPEKLVEEWKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK24</accession>
    <name>A0A914YK24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20693.t1">
        <property type="protein sequence ID" value="PSU_v2.g20693.t1"/>
        <property type="gene ID" value="PSU_v2.g20693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20693.t1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30413" checksum="BA32911A67505032" modified="2023-02-22" version="1">MLPKHFVNNSNQLNQKINIPAGFGISLVNNTTSEELIYARFRGVQIIFCRVEKIYIFSGHVLSLQVDNQLLNAETWHFLYCQVNALKGKISDESDSSPNSSLLEPDQSSPIFPAIKIEISYTPMEDYDAVDCFRIKFCDMCMHIDEILLWKLVQFYQDIPDISSSAVSLKSHAETISELTESDAVQIRKCYFGTLDLEFGKIALTVLTVAKSDLPTELDTLKRQFQIKLVSFENAIVSLPPFHRFRRAFESFEILIENLTEFYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL26</accession>
    <name>A0A914YL26_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YL26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20053.t1">
        <property type="protein sequence ID" value="PSU_v2.g20053.t1"/>
        <property type="gene ID" value="PSU_v2.g20053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="36"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20053.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44620" checksum="3F3E74072D43F936" modified="2023-02-22" version="1">MLKNITHKSHITVTLRFLQTSITVHPETPSNRKALRIAVIGPPNVGKSALSNSLLNADLCAVSKRMDTTRWNTVGAITENSCQLVVVDSPGLVGIKHARDIVGAHSESTVLTDPEKAIARAEHLLVVHDATLPGKYLSHRILHILHRHSHIPATLVINKIDLIQRKSDLLELAKILTNGIVGDQKVATERVRLGKMGQVNVKDEIKLHTPFEEKDEKWKLLYNRLMNKPTYKISWGETRKLFGNECGWSNFDQIFFVSALTRKGIDDLRTHLQSLSHPLEGEYPMNEDSITQKKPRLICSEHIRSEVLNHLPGDVAYNLRVNVLEWDVTGEDENVKIRIVADVICDKLHWAHLLAKVIPNIEQDVSQHLRNLFAGHIEICIRAKHGKDVIGPKKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YME6</accession>
    <name>A0A914YME6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YME6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20556.t1">
        <property type="protein sequence ID" value="PSU_v2.g20556.t1"/>
        <property type="gene ID" value="PSU_v2.g20556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20556.t1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38997" checksum="26A14D3D564BE326" modified="2023-02-22" version="1">MQECIICNKNIDLNLSSFTEHFRQHDKRQEDIRHGRIRCGFCGSEFLNVKKLLQHLIAFHQVSQPKMNVTSSASTSIGSQRNGSSNNQTMIEKSNKVLLLMDKDKKIDGLLKSAKEKIVEHLQSIIEDYKTNAYISEHLRNEISKSLLESVSTTIQVMSNVVKEASLKDYSDKISLFHDEIILSFTDKFDDEASNDSIKQEFSTVEQEITSEFSPSDFPSTSVTATMNETESFDPIPVFNLLINRTPIILDASINVKEGLKRLANDMLNECQEFYDNNKPDEPALFHDVDVYEEFDSPLGRIILYILFNDFNPEFSKELITLAWKEAYAALIIVQKILIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMK4</accession>
    <name>A0A914YMK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMK4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20816.t1">
        <property type="protein sequence ID" value="PSU_v2.g20816.t1"/>
        <property type="gene ID" value="PSU_v2.g20816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20816.t1"/>
        </source>
    </evidence>
    <sequence length="575" mass="68255" checksum="51B514DDEBF3C29A" modified="2023-02-22" version="1">MLESSFKESLDPSYLKIFTKFEDVLKATKDDKGKRMDLIVQFSSIYMMPKELWDEYFELTHKTPHALEERERTTIMVLPSVYHFFYKYPIGARDHFGPIRLPKRKLLRWKVAAISTFDLGIGISSNSETLINDISFPNENIERKWRQYEKSSSSMPPQKVVKLYQKMKALFAKIEAIDKNDDEKWIKTLLEVEDNEFVEHNIEYRIGTNLTNKKLWKLYIQYLKDQQQNSYRLLHTYSKYCRFFLDDVEMKEEYRQAAKDYGSPVEVPWKNPFDFEIFGENVLKNYFFKNDNLSYNYYEEEENNKVTVYFNTDNLIKQQNFPFKTPFIHYIIQNANARVLQNLFKCCKWFFVKNPIPLCYSLVTKQRPMEKPQINFYQQSVEVVKIALNETGIENIYLSTALKIMSLRDRMMLSKFIPKMFKCDAKYISIVNQNLTFKELQFLIGHGNVVDLSLSEVHIIDGDNKKEVVIEDIIKLIPKAQFIDIAGIASTPKTAQILSQLKFENKMESFNLKMENLEPNDFVEFIKKNLAPKSRIFIHFKFNHNVDNIFNFREIVENAINTHWKESEKPMIKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNB9</accession>
    <name>A0A914YNB9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mur ligase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNB9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20898.t1">
        <property type="protein sequence ID" value="PSU_v2.g20898.t1"/>
        <property type="gene ID" value="PSU_v2.g20898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43692">
        <property type="entry name" value="UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43692:SF1">
        <property type="entry name" value="UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Mur ligase C-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20898.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="23748" checksum="66D8DABB461AF2AF" modified="2023-02-22" version="1">MDGVQYLDDSKGTNVGATVAALRGFDQRVWLIAGGLGKGQDFEPLAVAAASCGRSVLIGQDAKLIASVLDAHDVRYRFCEGLEAAVQAAAEQAHSGDVVLLLRPAPAWICSKAITIALTSGVNAVRPGRTALPAFDRPLLAATLMLTLFGLLMVYSASIALADGPRYESYGRYYFVIRHALFIVVGCGAGHVYRYRAAASVAEVGRASVCSGYFLAAGGAGSRHWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNX1</accession>
    <name>A0A914YNX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Piezo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2550.t1">
        <property type="protein sequence ID" value="PSU_v2.g2550.t1"/>
        <property type="gene ID" value="PSU_v2.g2550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="706"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="844"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="897"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="5">
        <location>
            <begin position="26"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="4">
        <location>
            <begin position="821"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2550.t1"/>
        </source>
    </evidence>
    <sequence length="1229" mass="142019" checksum="9C6A7567EBEA6122" modified="2023-02-22" version="1">MKSKDGSRIALGYQVKDMGQRKESSMSVKVNPMPDTPLASKKTSVTSLPSNTSKKSPKISLQFAEKLAAMKLEKERMKNLAKWENLKPILETIKSYSYVLALIILMAWSLCYHSWSTFVMLILSFVIWMHPNSQHFYYQIATFIVGYAEILLVCQFAFSLPFTQEELPDEKPGFLRQLGLEKPRNNAPVFDILLKSLFNLAFWYALKQKFIQQRTPKGGKVGALEKPKILVSTGPEKASSVSITTATTEQQSQKRPLIERIKAHISNFWVFLLLILLLSISLYNPVVFYRVGYMTFFLVFLSFFVISFPLWRKMLERFWMIMIGYCILVITMIYTYQFHGIPELYSDYLGMSYPVAKSLGLERISSSELLFRLLTPISFLIVSLIQLNFFHEKMMKSTQKWEDDVYGLKLRFLMAKLKLFHRQMNYLEPGLLEEGEEDGDEKAAHIKGLAPKQRMKKVIGEIERKCKQMLSYRQSIWNILWRFAEIHIDKIIAALIVYTAVKEISILNLPLIICVTVMIPFQTRIPSISDFVCVIASAVIILKMLFQMEFIEESSIQVTCFNANYGNENGTVVHNYGTWFGLTKVSSISDYTKEHISIILCLVFRELIKIRQFLHRKRNRLEEPPPGIIFFGIDRIHADVDSYHCLLYFGNYFFYKFGVEITFIASAISIGIRNDLIAVFYVLWLLYMLTRTRLEMSKLWIRYAGFYVICFGVQYLLCVGMPNFLCINYFWDDWDSNLIEWLCLPSYKMAPIPEKFIADFIVLLCITSQYYVFKIEEKFGPEYPGGDNHTISSRTNTGRRFIFNFDLRQFRIKSSIPLSISKVPDFISDGTTLLDRFKHVFFMYFYWITLSIIFIAGTSRITLFAAGYVFGCFFFLWMGNSLFFKPIVVCLQMWDNLIYYNVCVILLKTLLQIVGCVYMGDMCQHFCWLLQLFGIACNKVGYSPIELIDPEVLIQCDIPMTEAGIFYDNLCFVFLLIQRRIFGSQYFIHVIAELKAQRFFASRGAELIEKINKQEIEEAEEREKEMMQMVDKMVNKISKKQEKTKHKERNPEGILSDISSIHDEKSLLDTPDGPPPPNTVTIKDTIMVEVQGYCPTSPSETLTPHFSPSSEEAETLSVGSLDHMDRIQSPQNYYRQTSADTIRSPQPLSFDDHHRRKSANPDACGRQRSEDESETWSINSSDRPNSMKARRKTTGEGGVKGLGPLQLLNFAIKKGAIRDAIIDQFEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ88</accession>
    <name>A0A914YQ88_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g2342.t1">
        <property type="protein sequence ID" value="PSU_v2.g2342.t1"/>
        <property type="gene ID" value="PSU_v2.g2342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056075">
        <property type="entry name" value="DUF7658"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057017">
        <property type="entry name" value="F54D1_6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057018">
        <property type="entry name" value="F54D1_6-like_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057019">
        <property type="entry name" value="F54D1_6-like_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF60">
        <property type="entry name" value="PROTEIN CBG06057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24678">
        <property type="entry name" value="DUF7658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24469">
        <property type="entry name" value="F54D1_6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24462">
        <property type="entry name" value="Ig_F54D1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24464">
        <property type="entry name" value="Ig_F54D1_6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037378726" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1324"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="9">
        <location>
            <begin position="191"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="8">
        <location>
            <begin position="645"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1356"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1373"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2342.t1"/>
        </source>
    </evidence>
    <sequence length="1434" mass="164014" checksum="DF70C63AC8BC5F72" modified="2023-02-22" version="1">MLSLSFISIYLISSSSAQLQSGIGGGPQNYNPGLGLGLGGINADQNSQLFTGTGNNPFYGVNLVPFGPEAGDHKVSPGFLTSGQTINLHMYFPYYGGFYNYTTLSVNGYMAFATVLDQGPTINVGPDSTDWPRQQDPAMIAPYLCKQQVPQTGGPALKSGVYFRVIMRQSMFGRGSNSNINVDTASMAGSSFFGNRFDKCPGTADNYIRCDSQSDYFLDEMMRWLQEGVAGATAFRADAAVVVTWLNTASAVSNRADFDNGELATYQVIWLTDQPGRLSYVILNYDKLGFDAADVRMNSRNGRCQALFNGGNHTGLVPVDPTFLYKNTPKVLAQRSGVPHMVRGRYMFRVDDVVRPGGCSNKTGGSYPMMIYPNIVNMLGEMTVDVNALCLDRSVTYKMMIEQRQVATCTVVNAAIARCTIPKIYDWGTKTVFFQPESTGANDEKAFVGYIYFVPPTLDPMRLDIGNIYDWFKNPIEYPVMPISWFPRNFTNPDLNYQDNMQMRISDDTLYAVQLGLYVIGYKETKDENIKKFRPEHRVLCRLTTYANRNTYEYRFNAQKERINLNQVEHWYLNDWERMHELYTFRFGYLKLAPIRANDQNVAPQLISGLVSSPISLHWLWTSNNPQYDLNSFSQQQADARTEFVVKKATEMCHDWYDEDGAQWNFLRDTETNASCPCMEIQAKYDLGRFMPHPRCSQVFRDITCTTMIGAKNCYMSASNIYGSYAGTGRYGESESTSRFPTHYGQVCCYDEKGYLMQTTYQPVIKVIEQTPYNPGFPLRAYEFGTAPYMGQFEVPGLSAFHHDYMPYFLCCKYANFRCQLFYWRRPSSGCQQYQPPAIGQAIGAGSFNTIDNDKFVFNEPGVYNFLYIPQTAFTPEVRIQVRLERYPNRKVDFSMLGRTISQEDLVQPSNATVITGVVIEATGTDRVHVVARKDTFRYRYRTSIIVGNILRYFDTMRLQRFRGVLVYVNNVERGQPEVYVVLEEAQIGIYIRESAAVDIDRLTMYQESMGMLDVTVSVSPQYGVRPDGDKTREQDIRQRYNLPRVAGLIRPFPDQATGSLYNTLTINDINSEAIRQQIIQNYRVPGSGGASSIDYNQGQVNQYMPTDNMFTTTRDEDKMFDAFPETFMKSEPIYKVAPTYEGPLHRFYPKTGAMLEQLLQNCIEIENNQIMNIQPYQGQIYDQYAFRECPDQPAEIKADCGDNVPCLYDYTMLNAKIIAHNSKDTWNTFVRERMEAVRQYNSCGPINIEYPEYLMKTPALAPAYMQGDAARFECFQTHWIKGDHEYKCQMVVDYNDYNRYRFEWNKGSQPWCRSREFENMLKWLTAILSVVAIIMIMVLIFLCCWCVKQKRRQEQDQGSENSRIRRDIDSFNPRTDTMSNYSDKRDTFTRLTPNGARTDMKPDDSPTYSTPELRSRHRHDPENEKLLGLTTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQP9</accession>
    <name>A0A914YQP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19694.t1">
        <property type="protein sequence ID" value="PSU_v2.g19694.t1"/>
        <property type="gene ID" value="PSU_v2.g19694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19694.t1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19621" checksum="A4DAA0FB74457C2E" modified="2023-02-22" version="1">MRRMLQDKESQEQKEKREKIFTSYIHGHKDTSSGQSSNHSHNPPTLMSASGPITLDDTVGFALTSRPIRKLPYGNGAYMASEIVEISLGSHSTKQYLILSVTKQIFDNFAATHSRNLIPQYNQKIAENLISFRSRIHQISELKGSLTLLLTEHSNLSQKLKAAGVPIVSSFFVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR92</accession>
    <name>A0A914YR92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR92"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2169.t1">
        <property type="protein sequence ID" value="PSU_v2.g2169.t1"/>
        <property type="gene ID" value="PSU_v2.g2169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2169.t1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50455" checksum="A0ECDAE10E56B333" modified="2023-02-22" version="1">MSESEYIHPSLLLDEESKFLKMGSHDFSLKFMYQLVFNVNNLTHQYPYVNEQPYFAPLKVGEYLVILDAKKIAKISDIRHDSLSPWNKKNRKSKQHCFIVDPNTGTCRRADTREDREQSNAHEYYAKHPDQKVTKMIFMACKPNRARPTPNTFAVIYYKVDEALFHQSLIPNRASSSHNQSGRGFYENDILLEDSEIKEDPEKNILSLLDGMLFAKSSNPRANNNGILNINESSSTSAVSTVSQGSGRKRMAISETSAVKRPAKITILNPVGSTSAPLSSGLHPLPSSSSSDTILIRKRYFGLFEYHPYPCDPPSGLQKTRQSSYIDQAAKNYYTANNLSVEVYHTSFPFQLQKGKDLLFQGKRKCAHCNADITVAENSTIITHYEPFEYLVSNTNHITTGHGNRIICNKFSCLKARYPFIDEQCFIVNNTVSQAEAKKVFDLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRA3</accession>
    <name>A0A914YRA3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2545.t1">
        <property type="protein sequence ID" value="PSU_v2.g2545.t1"/>
        <property type="gene ID" value="PSU_v2.g2545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2545.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="26020" checksum="9054C1183F477D81" modified="2023-02-22" version="1">MKIIFEKIECKLWLLGSLHIRYPDFPQNFLPKLYRSDAKDVSLHSNINYLNQVKLLASSAINLSLAGFVLEESGQHILLENFIEYFPMLEKFCIYWNDKNIPPCKNYEKVLTSLQKFPAFRELMFYNLPDNFNIHTFLHCVKHIKIQFKTKLAFMNESSEAEVENRLEEIVDELNKTKNFDYCPTLIWSYTLRKLKLRKYAPLESKIDQYLKHKRLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRK4</accession>
    <name>A0A914YRK4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="7">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="7">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRK4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g264.t1">
        <property type="protein sequence ID" value="PSU_v2.g264.t1"/>
        <property type="gene ID" value="PSU_v2.g264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000029">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="38"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g264.t1"/>
        </source>
    </evidence>
    <sequence length="750" mass="83824" checksum="F20FD0D42CD596BE" modified="2023-02-22" version="1">MLEHRLWSLAAHASKAFSRRLLSTAQSAVSAEKIRPVEKIRNIGISAHIDSGKTTVTERILFYAGRISSMHEVKGKDDVGATMDFMELEKQRGITIQSAATYVDWHGTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCGVGGVQSQTFTVNRQLSRYSVPFITFVNKLDRTGANPNRALDGLRNKLGHNAAFIQMPIGMESNYKGMIDLIEEQAIYNEGEDGLIIRRDDIPQELRAQAKDLRQEMIEHLANADEHIGEQFLNDIHPSVEEVHAAIRRSVIKRAFVPVLMGTALKNKGVQTMIDTVVKYLPNPSEVENKANVEINGEEKKIILNPTRSSSRENPFVGLAFKLEAGKYGQLTYFRVYQGQLSRGDTVYATRDGRKVRVQRLVRMHANAMEDVQTAYAGDICATFGLDCASGETFCSEEKLNLHCEAMHIPEPVISMSMKPLNRKDGDSFIKALTRFTKEDPTFRKEYNAEAKETVVSGMGELHLEIYAQRMKNEFNCPVELGKPTVAYRECLAAPYKFHYRHKKQTGGQGQFGQIEGVVDPLPPEKNTTVEFTDETFGSGIPKNLFPALKKGLDEIVKEGPLIKAKITGINVKIQDGETHAVDSTEIAMINTMINMMRESFEKAQWILLEPIMKIEVVVPTDFQGSVVTSVTQRNGVISNTSVAEGYTTITAESPLSEMFGYTSELRSLTEGKGEFTMEYSRYAPTSYQSQEQVMYDWKVANGLIDPSSEKGKQQRKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS24</accession>
    <name>A0A914YS24_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARID domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20199.t1">
        <property type="protein sequence ID" value="PSU_v2.g20199.t1"/>
        <property type="gene ID" value="PSU_v2.g20199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:brahma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:SWI/SNF complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:nucleosome binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045893">
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    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ARID DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021906">
        <property type="entry name" value="BAF250/Osa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656">
        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656:SF5">
        <property type="entry name" value="TRITHORAX GROUP PROTEIN OSA"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="288"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20199.t1"/>
        </source>
    </evidence>
    <sequence length="339" mass="36519" checksum="18176456E559F6B6" modified="2023-02-22" version="1">MAPQQWLPPHGPDGPTSDAMALSQQQQQQQQQLQQSLSNYPGQGYPPQMNIYGGNPQMPPTSGGNNGYWMQPPQQQQQQQQPRYPMQQYPGYGPPIHQGYGYPPMQQHGLPPPPGDWGRMPQMHYPTSQQQQQQQQQPMQQPPISGPPQTLPPPPPTQQQPPQQQLPPPPPPQGAPTPSQPSSSSTTTTNIAAVAQALQSPGAGSIGGHDEGGDDTKSIRSTSSVPPPHTPARTPAATPSASSGTPGTSTAKTSSTPASSAKHAPPPSREEVLEKLCYTTDQIGPELTMQRRAFFDTILLMFEKDGEAVTGAPQVSKSPIDLHKLYIKVKEKGGFEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSN5</accession>
    <name>A0A914YSN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3022.t1">
        <property type="protein sequence ID" value="PSU_v2.g3022.t1"/>
        <property type="gene ID" value="PSU_v2.g3022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3022.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12473" checksum="5DA9717ACD6B0215" modified="2023-02-22" version="1">MRIITINKHKKKSSAPLPQQQQQLPEKSQSGPQKFQYKPALTYTVQQAGKDKAIVYHRNTNQPFIKALASPAGTPQPVCLVQPPNQPQQQPPQPQQQNPPNQPGVPPSQQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT26</accession>
    <name>A0A914YT26_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="3">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YT26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3150.t1">
        <property type="protein sequence ID" value="PSU_v2.g3150.t1"/>
        <property type="gene ID" value="PSU_v2.g3150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038070429" description="cystathionine gamma-lyase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3150.t1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8924" checksum="E0B54E6474E59B08" modified="2023-02-22" version="1">MFLRFFALAVSLGAAESYAAVPALMTHDQVALELRLKVGITDNLIRLSVGLEDKKDLIEDLDQALKIAVLSNQLGKQTFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT80</accession>
    <name>A0A914YT80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3369.t1">
        <property type="protein sequence ID" value="PSU_v2.g3369.t1"/>
        <property type="gene ID" value="PSU_v2.g3369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="324"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3369.t1"/>
        </source>
    </evidence>
    <sequence length="621" mass="69124" checksum="F1EAB43C754FE446" modified="2023-02-22" version="1">MSSGSGRNTNSNNTNNGSAGNGSNEAAVGNGGVPAGEIDSPKKQCLAALARLDLQPGVPELFNKEHVTRGVVLAGDQQIQLSSNAFGLKTESLPVHQYHVDFMKTLARERNGQHTFPLVQDETGNPNFPNQPLRKVPDYTTYQNRIMHQNLFAAFIRKYPNVFGKDPDVFCYDYAKTLYSLTKLTSLDTPMELTEAETQQAINRPYKVNLILKKPADNVFDIRDWNESIGDGLSEKPAEIIRFFELATSRYASQHPEDHVMFESKKTYYMEPRKFGFTSPDLGGGKYLAAGASKVVVCVEGNRKEGAPAVIIDSKKTPFYQSMNLLEMICAALQTGPNITPNRAQWEIAAKYVKRLECFPIYGNRQDSTVLLSTLTTASAVDTMMELDGNQISIAQYIQQRYQVQLRFPQWPLATGAKKVRGNRVHIPLELLHVADYQRVGNGNITSSDIATIVRACAVNPSVKSGEIINCHQSFAFGADGFMEGAHMTVIDRPLDVQGRIIQAPAISYANGNLYPEQNGKWRLPKPAKYVRAATLKSWCALFLEVRGERMSFAEYEQFVAKYYHECRNRGIALGEPLRIWSVPCDQAPIEKAFEDASGAGCEFILIGHSDRDSTVHRKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUZ8</accession>
    <name>A0A914YUZ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUZ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g38.t1">
        <property type="protein sequence ID" value="PSU_v2.g38.t1"/>
        <property type="gene ID" value="PSU_v2.g38"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g38.t1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10571" checksum="3B838BEB7C3AF474" modified="2023-02-22" version="1">MSTIGNMLIRASLPGMDKGLKDPRRATVFGEQGTRDLCRKLAASDLDIPDPDMSKIFDDGKMPTMITPTPFQKLRKQKPASELGAKIDRIASIRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV72</accession>
    <name>A0A914YV72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinesin motor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YV72"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4497.t1">
        <property type="protein sequence ID" value="PSU_v2.g4497.t1"/>
        <property type="gene ID" value="PSU_v2.g4497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4497.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18461" checksum="705C80D95E73A9AB" modified="2023-02-22" version="1">MVSPGTNSVENTLNTLRYADRVKELGSDEEGHVNKQPLSDAEFMLEEIDDDEYYSKSINTNNTSKHHHNHNNHNHHNHHHQNSNSTTNNNIDLEENLLIKIRNAEERTFEDHHALLTVCDKFEELMQSQNDTDNDVEKYAKHLISTCERGSEAMNNLKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVD9</accession>
    <name>A0A914YVD9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVD9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4556.t1">
        <property type="protein sequence ID" value="PSU_v2.g4556.t1"/>
        <property type="gene ID" value="PSU_v2.g4556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="51"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="243"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="347"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="499"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4556.t1"/>
        </source>
    </evidence>
    <sequence length="1018" mass="114098" checksum="374C74147B1B4A29" modified="2023-02-22" version="1">MDGTLYFSYNKKEDATSYACSLSLPSIQSGHYGPFFNLILPQSVPGASSSPKIDEFQPQIFPEIPTRGQAVFIECFAYGFPSPKYKWSRVDGEPLPARHRILNYGRVLKIDSVTVDDAARYKCVAFNEFGRESAEIQLLVHSPPTLLKPLINQRIATNTSANLECIAASQYSNQVTIEWFHNGQPISPLLMPAAERKRFKINENVLNILNAAENDSGIFQCIVSNDVGSISSSARLTVEDATPKFHGNIFPRRVFVVEGSKLSLPCLYLASPRGFAHWYSASSSDAIPVDPHCRMRQKKELIGNEESISVLEIDNIEKSDEGIYHCETANGIGEGKGVVQVRVVPKPQIVVRPPSLASGMASNSIYQTPTKITCEVELACELPDDCPEALFDWQFNDQSVKHIVTRGLPLKMNAKEKAVKTYWKDTDEEDVRSSRWLFETPTNKNPKEDKRKKVKHVRQLSQVEVSPEFSSANIGRFSCTSIYGSGSSELTEPKTLSSAPTQLKIIEVNRNYVKLSWKQPANQKRRGFGTNVRMEGYQIEYRTASNRQWRPFPNGLFKTEDRIIGSYLLKNLESNEKYQFRVRSRAADGSMSAPSLHTEWIETPQSPPLDPIQRLQWRTIDDNHLLLEWDPVESSHQSGPNLRYNVSWSDPAPSIPALAKFQADTFAHSEMVSEPNIVIPIKVYKPKKKKIKKNKNRVEDVTESCFTIAVGVQPLNDVGAGPTSTDTVVQISTEGPKRYADNLLAIPVNSTHLNLTWEWKNAGGCENIIGAYIQCLETSAFINDVSSFSVNHSSEDETITVKKVPSLTRDMDSLIVNQSVPAHYTSWLIHGLKPGTEYSCTVRAFDQYGRYGNTSKHATSARTLDPAPPFPPEITMIKLQEMVNFKDDSLTTLIEWTAIPLRNSLYDNVTDHQRGYKILIYVSETAERPIILTLTEAELQNPRKPSARIDGLKLMYYYTIKVAGFNEGGIGPVSKPTSIRLGVSSDFNTANSSFYSLVNIFILIIVMCLMQFHASKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVM5</accession>
    <name>A0A914YVM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g463.t1">
        <property type="protein sequence ID" value="PSU_v2.g463.t1"/>
        <property type="gene ID" value="PSU_v2.g463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037964085" evidence="1">
        <location>
            <begin position="28"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g463.t1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23388" checksum="3FE14F7A7182E173" modified="2023-02-22" version="1">MQLFQLLLINLKKLLLLLLLKKNTVESADKNDKVGENDNIDVNAPTVEIIKEEKPAEAIDMVDKVQIPSNEVSLQDENGCESAAAVNLDDISDKVEKSVDADKKEEEMIVEIVGASTVTADRAETIGVKVEEIKSADKNDKVEEIGNIDDVNAPTVEVVKEEKPAVAIVIVDKVQLPSNEVSLQDENGCKSAAAVNLDEKSVDADKHEEEMLVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVW1</accession>
    <name>A0A914YVW1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVW1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3793.t1">
        <property type="protein sequence ID" value="PSU_v2.g3793.t1"/>
        <property type="gene ID" value="PSU_v2.g3793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3793.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38888" checksum="942E1857A726CFBE" modified="2023-02-22" version="1">MFTQDIGTQANSINFDVQTQIEKGDFNQDIETQAEIVIMHRQTSLHSEDLEPLESGFSYGGDLSYLWSDFDFVEEGVGGDDDDEEYDEEEGEGEEKQQQQQHAEDGRETPKAIGTEVRTDLLAAEAKTEFKSDFKIEATTETETKTTINLSDLDESRRERMMDIGIQTGVLARVQHIYGGKGKTGPGQKQEHQIPEPGVHKITLRKDPKSRISIPSSSEPTLEKPGPSSASGPRIRTPLIPPPKLIESAKNTALHGRHWEKQQSVSDLRTRLEKARQSSQSSGNLWGSKDEGSTSSLQIFGTETASSPKPSPQPPSSGGPSATTSSTEISKTQEEEEEEKEEKKKMQKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWW0</accession>
    <name>A0A914YWW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWW0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4590.t1">
        <property type="protein sequence ID" value="PSU_v2.g4590.t1"/>
        <property type="gene ID" value="PSU_v2.g4590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037563678" evidence="1">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4590.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25042" checksum="7F331C9CCA3C520E" modified="2023-02-22" version="1">MLMVKSQVLRILFIFCLLKFVFGLPFPSSSSKKRDVSSTIQKTIDELYSKLMDSEFENLRVKAAKLLPIDIDRENINFYINEEEEDDDGFNRKTSVCENSTSSFTPPFPAFVTPFMTLLASQYTEWRHRNPKKLSCLVSQLKSIDSHPCPHENSSCVVISLPNNHVFFGCMNDKTGELVAPKNWDVLKSTNDSDKFLIDFRGLFFYQRLLPTLSVLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX50</accession>
    <name>A0A914YX50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CLASP N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2659.t1">
        <property type="protein sequence ID" value="PSU_v2.g2659.t1"/>
        <property type="gene ID" value="PSU_v2.g2659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="2">
        <location>
            <begin position="32"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2659.t1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45090" checksum="2102CC6B48331735" modified="2023-02-22" version="1">MSSRLRSSPPSGAGAVSENDFLEAFAETQPEKLGNLRGCIISNVPHSTDIVLDNIGLWKKCLIDGLKELRSTLTREYCITIAFFAVKLRSRMMPLVEQMFPNLMNLVKNSTKIISSSAIVLSEYITKYVNHSSLITMASGYMSSKSGPVKANVENILFTMLLNWDKNLLTSHINSIKDIIKKGLTDANAETRTAAKDAYFAFYDKFSLQALQLYESLDSSRQKALNHPKSAALSSHSLSRQSSVITTPKPKPFIARTPSFTPQNLSSLTINNNIPKSNGFSSATAATRRITNIRKPSPIRQNRSAEAPAVLKSIGTRQHSIPRLNGNNNGNYLHSNGGVTSNNHHHREGLKHQIPLVRPNHPSAAPASRPSRPSVFGTIRSSSLPRTISDSALGSSNIKPSNSIEKRMLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXG1</accession>
    <name>A0A914YXG1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YXG1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2779.t1">
        <property type="protein sequence ID" value="PSU_v2.g2779.t1"/>
        <property type="gene ID" value="PSU_v2.g2779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2779.t1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18149" checksum="B63756E59CB43104" modified="2023-02-22" version="1">MQKSFYEFDAAKELIREGIGKYKGYDEFYMMLGQIYVQEKKIPEARKAFVQTIVEGIHQCRNSIQTWLELIRFENSQGELVKAGLYLDMGNIIKHRHNELLLLESFRLELGAGQKEIAQHILSKALQECEKSGLLWAETIFLEPSHSRQLLLFILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYX5</accession>
    <name>A0A914YYX5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYX5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4837.t1">
        <property type="protein sequence ID" value="PSU_v2.g4837.t1"/>
        <property type="gene ID" value="PSU_v2.g4837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4837.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31991" checksum="08C0816F90459C01" modified="2023-02-22" version="1">MGSKFPKVQEEGIFFVTVITTTSNNATSAEENTELATDAGALSKLSKWLSSRSDGVQELALRCVANIAVEFSGETFSTNGITTAVIKLCGSSNPFVYEEAFNALNTLIYSEAYICRNIIQYGALKMIKKAFTHGPSIKLLGIKFLKIVASFDVRRLTDMIINEKFFPLILKQIRDGSTDVMKAKSAKVIKIIVSQNHEIIPSLIEEEIISVICDSLQSESDNLLINALLILQNIIDSIGYEEIREKFENSNGPQLLQNLHVHENEDIQELSNQINLLVNDVKEAATVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ18</accession>
    <name>A0A914YZ18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZ18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3279.t1">
        <property type="protein sequence ID" value="PSU_v2.g3279.t1"/>
        <property type="gene ID" value="PSU_v2.g3279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF126">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3279.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13357" checksum="81C57B70B00B6872" modified="2023-02-22" version="1">MRQQAVGVKGTLMCGDKPAAGVQVKLWDEDDGPDPDDELDAMFSNPDGTFEVKGSTRELTTIDPVFKVYHDCDDGIMPGQRKIKFKIPTQYIAAGGVPKKIFEIGILNLETKFPGEERDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZZ4</accession>
    <name>A0A914YZZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZZ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5669.t1">
        <property type="protein sequence ID" value="PSU_v2.g5669.t1"/>
        <property type="gene ID" value="PSU_v2.g5669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032135">
        <property type="entry name" value="DUF4817"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16087">
        <property type="entry name" value="DUF4817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4817" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5669.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9722" checksum="677A7F78122D1D88" modified="2023-02-22" version="1">MASARRVISVIEKAKLVCWVEETNSVAMAARRYRAEFGHPAPKLETIKKLHQQFMETGSVTSGSYSPSQSATMAQLSSVRSFYEPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1E9</accession>
    <name>A0A914Z1E9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1E9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4095.t1">
        <property type="protein sequence ID" value="PSU_v2.g4095.t1"/>
        <property type="gene ID" value="PSU_v2.g4095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4095.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="36114" checksum="ACF51B16BED5F4B5" modified="2023-02-22" version="1">MSIRTGFQGCRPLEAKLIQSAMIMVLGFERISNSKVDLPSEIRGIDRAEILQIGIEAVIIMMNKDATKFHPLVEGIRPGGRYDPFQSRTFIKTLKTNNVTKFDAKSSYFGNLKQLREMFLLYQNVYYPVTKIVGDDAYDKRLDRDECGLNVFARFMIDFFSMPPQRQLKVRNEVQMKREKFAISLLKPDGKRLFVPLKLHEVPADFMFVEKDKDHLIWKQHANSFIQYADKCYGCTLCAFKDKELNRVKRHQTGMHKNYGNPIYICMMCKTPIEKKKRQEHMKRCFGCDPRLVVEGHLCPTTTNFMPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1G9</accession>
    <name>A0A914Z1G9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1G9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4113.t1">
        <property type="protein sequence ID" value="PSU_v2.g4113.t1"/>
        <property type="gene ID" value="PSU_v2.g4113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4113.t1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24567" checksum="F17B50CFEA4013E2" modified="2023-02-22" version="1">MNRLLWLRDQGNPLSHPQDTLLASPQDTPLFPPQDNSLTLPQDTPLSLPQDTILASPQDTPLSLPQDVPSKHFSSAENIPDSRSDSKSPAPQSNTPETPVNNPPPSQTSTFSISANYLDNRRKNRSLSKLKNGLAVVYAQDPVTREPCFGEIYNYDVTEDRLSLKLLHLDEFDDVSHCYVVTSSEPVIVVSCESLLCPEPIPIYRRRRNYIRMPYWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1H3</accession>
    <name>A0A914Z1H3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1H3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6205.t1">
        <property type="protein sequence ID" value="PSU_v2.g6205.t1"/>
        <property type="gene ID" value="PSU_v2.g6205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="8">
        <location>
            <begin position="32"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6205.t1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34527" checksum="38BD353A024B2259" modified="2023-02-22" version="1">MAIMAANGAKPKTRKGKRFLENRASKIHENDKRCLAIHGGKTSPILNEVLEYLYLLKKPLSQHLKRHNVMHLFEDETLLERFSGKFDASLFAFGSHQKKRPNTLIFGRMFDQHILDMFEMRITNYIPAMKFGTFAPTLGSKPCILLQGTLFESDDEMKRLGNLMVDWFRGIKVPNIRLQGLETVISLTIVEGVLLFRVYRTQLKKSASKTPRVELVEIGPSIDFVLDRKKIASDSLYKSAMRVPDELRVKPRKNVSQDVFGTQKARIHLGRQEIGRIQTRKTPALRKAPRRATSGANSIPLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Q2</accession>
    <name>A0A914Z1Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Q2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4188.t1">
        <property type="protein sequence ID" value="PSU_v2.g4188.t1"/>
        <property type="gene ID" value="PSU_v2.g4188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043193">
        <property type="entry name" value="GLOD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466:SF1">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21701">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="121"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4188.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30583" checksum="19F215CB87FA717F" modified="2023-02-22" version="1">MVKSARTLHYNIKTTDRQKTYDFYVKQLGMKVLRHEEFDKSCDAGCNAKGGNEWSKTQMGFGPEDENFVFEVIYNYNKTPIVHGNDYGGVLIQTQKTIQVDKDPEGFPLTLENVANVPSNPIIKVSFNVDSLQKALDFWVGLLEMGVISQTNDRVVLCFGEGQTYLELAAKGVPIERESASGRIAFSIPEDDLLPLQSRVQSYDESRIHTKLTELETPGKATVKVVVLTDPNGHEICFVGDEKFRELSKFDPKADELYLEAIKKESCKKCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1R2</accession>
    <name>A0A914Z1R2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1R2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6642.t1">
        <property type="protein sequence ID" value="PSU_v2.g6642.t1"/>
        <property type="gene ID" value="PSU_v2.g6642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6642.t1"/>
        </source>
    </evidence>
    <sequence length="695" mass="72885" checksum="A4FE036DE26485B9" modified="2023-02-22" version="1">MNLQPSEGTTTKSFENTQRTVSIIPLGGGQNVDGGSTTVEPKVETIITESNTEVPLEATTVLSETTLKEIISTTIPSATETTQQSSSSIIPAIVESEGISATQSTIEPINEVTPNQPIIPVVVIGDSEKVATTPSGDDITKVPSTKTNQESPTTLINSIAQEDSATTLIVTAQASDVEATTVQNSETTTEKEGITILTTDAPTTPVSLETTTDVIDKAVSKVQALAEKAGDLLKQEKEFSTTQIPVTDDSTNMAETTKTIVVENEGTTIMASVTEVNTLLAAATSDSKNKIVISPSDSEKETIQTTLESAEALSTSASPERTAASEITEKVEATTKSAEQETAILSTVTSDSVSTTQEPITITEKRTESPLPITVSQPESITGETTPTESTTVLSETVSTIGATKTAEQTTTEASLDNKAPIVVLPENVSTVSPETATIQENEKTSEIPVKESNEEITTTFIPTTTDVIDKAVSKVQAIVAAAGKELKGETTILPSEDEASETTIVPLSEVKNESIPVIIDKVIEKVDEIVKENAAATTTSSDMLTESVTETTTVEEIVTTAPLEGTGKIAVTNVEVSATTVSSTSEQPEIKITDSTTLLSEQSSSTKNPASIVLEKVEALNEASATEKVEENVDLTTTISPSTNIQTTMVTETPLEQSTTTDSPTRKVTEAVVLLSSSETGSTVESTTVNAKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2A4</accession>
    <name>A0A914Z2A4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2A4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4382.t1">
        <property type="protein sequence ID" value="PSU_v2.g4382.t1"/>
        <property type="gene ID" value="PSU_v2.g4382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="56"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4382.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="24281" checksum="28CE67F0F9789682" modified="2023-02-22" version="1">MRFSRGLLCISKICHNSALQHNNNAHNVTVKRQLFGFGQGTREQRVMEYAEKRLIGFTAQQMFDVVNNVAAYPQFVPYCKKADVRKVSDYVLEAELQIGFPPIHERYDSKVTALKPYVIRSVCTEGRLFHVLDTTWRFQPLPDNPKCCTLYYSVEFEFRSLIHARLAHMFFDQIVRTMVKAFLKRAEKLYGNPAIGYENMQPEVLAYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2V4</accession>
    <name>A0A914Z2V4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2V4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6680.t1">
        <property type="protein sequence ID" value="PSU_v2.g6680.t1"/>
        <property type="gene ID" value="PSU_v2.g6680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="121"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6680.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35738" checksum="E5D3385D6F80B06D" modified="2023-02-22" version="1">MIDTENMFLRLYADGRVLYSVRLSLTLSCPMHLQLYPLDVQNCDFDLISYAHTTKDIVYEWDTAGDPVQLKSGVGNDLPNFHLEKIDTGLECTSHTNTGSYACLRMRIKLSRLFSYYVFQLYIPTGMIVVVSWVSFWIDQRSTAGRVALGTLTMTTMTTVQSSINSKLPPVSYIKLVDYWLGTCQTFVFGALLEYAVVAYIDTNCKPAANRRQQLRKAQKRQFFMEETEFYQPPCTCGIGQNQENATFILCRPQISLREKFRKFFVKPDYLPAKIDYYARFLTPFAFIFFNAVYWSCAALLTSEYEKAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2X6</accession>
    <name>A0A914Z2X6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2X6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g670.t1">
        <property type="protein sequence ID" value="PSU_v2.g670.t1"/>
        <property type="gene ID" value="PSU_v2.g670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00142">
        <property type="entry name" value="Shadow ORF (opposite yadG)"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g670.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8166" checksum="F423392B21E36DA2" modified="2023-02-22" version="1">MRDHHDRAFEGGQCFGQRFAHFQVKVVGRFVQQQHVRLLPGDQRQRQARALATGEPIDRLECTVAREVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3P1</accession>
    <name>A0A914Z3P1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z3P1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6973.t1">
        <property type="protein sequence ID" value="PSU_v2.g6973.t1"/>
        <property type="gene ID" value="PSU_v2.g6973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="53"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6973.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35602" checksum="953B093D04519837" modified="2023-02-22" version="1">MPIPVKKELNEEALKQRIEEEKAKKEIEEKRRRTVFKAIEILADTVDEEKLLSLLDLLDTNSWKEVIEERFIGRVCGFPTCDNEIIVKTKQTYKLDKKKQKVYENYTEREKFCSLICFQKSENVQRQLAELPLWLTGESLGKKYNLSLPETLSTQLKSMKNDKIVEEKIEFIPDSLLVQLNQLNLGQIDASDSEEEEGDADADATTLGADDKQFLSNVHSFVTSTKVPPLNSNNSPKTPQIDVAKKPSITKMDKETMENKLEKLRTKFGKLPKEMQKKAPIIIEPHHGTTPIKTKKDGILKAEEVMERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4H6</accession>
    <name>A0A914Z4H6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4H6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6796.t1">
        <property type="protein sequence ID" value="PSU_v2.g6796.t1"/>
        <property type="gene ID" value="PSU_v2.g6796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6796.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15349" checksum="5303A1787D9EFD59" modified="2023-02-22" version="1">MKTSESSILFAVKDLIKIMAMPSNEEMIADERWDFKFIKNAEDSLLLEFEISEGIKRAAPPSFLMAYLLKKQIKAIKKETSVRPSNIAFWAIDKYSEEEKKRIYLQLQEACNTLSNTSAKYKCECEFVLFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4L6</accession>
    <name>A0A914Z4L6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4L6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g519.t1">
        <property type="protein sequence ID" value="PSU_v2.g519.t1"/>
        <property type="gene ID" value="PSU_v2.g519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g519.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27638" checksum="96E57EDD2E877A99" modified="2023-02-22" version="1">MVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVSKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4M1</accession>
    <name>A0A914Z4M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4M1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5194.t1">
        <property type="protein sequence ID" value="PSU_v2.g5194.t1"/>
        <property type="gene ID" value="PSU_v2.g5194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="4">
        <location>
            <begin position="59"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="3">
        <location>
            <begin position="191"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="62"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5194.t1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37753" checksum="F8D76A71BD094C02" modified="2023-02-22" version="1">MDPACSLCQVAITFHESLRNEEQTNLLQALKSVSNSDSRKHTCNLLDEICKSESPLQVPLCKDCATKICSDLRKRLLDLEEECLKYEKAYTDQQKKRKNLPYDAESIRRELQDVTMQEKELLEELTNLESEERRINNEIRELSRQASEVNDEGDALYRELRSNHRKLIECNEDTSSLKTEIAYMEEQIQNLRAVNVLDMTFCIGIHESYGTINGLRLGRLPHEAIEWNEINAAFGQVALLVQVLGEKVSATFSEYELDPRGNNSYIRRISGSKAIEYPLFGNGGWKPFGQLNLDHAIVGLIYCIMQVEGKLKELHKNKQQWVLKNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z522</accession>
    <name>A0A914Z522_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z522"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7068.t1">
        <property type="protein sequence ID" value="PSU_v2.g7068.t1"/>
        <property type="gene ID" value="PSU_v2.g7068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000139">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="781"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="781"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="813"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7068.t1"/>
        </source>
    </evidence>
    <sequence length="852" mass="95264" checksum="9423D736F84AAC63" modified="2023-02-22" version="1">MESDQTFLFHPAEEKQPKTFAFDHCFESSDPLSSKFANQEEVFTKVGMSVIDNAFQGYNACIFAYGQTGSGKSYTMMGSSDNPGIIPRLCNAIFERIQAETSESTNFKVEVSYMEIYNERVRDLLDPKKSAKTNLKVREHKSLGPVVDGLCVLAVSSFDQISGLIDEGNKCRTVAATNMNTESSRSHAVFTIRLTHTLFDHEKGFSGEKVSKISLVDLAGSERAGKSGAMGKRLEEGGNINKSLTTLGMVISALAERCGKKEKFVPYRDSVLTWLLKDNLGGNSRTVMIATISPAADNYEETLSTLRYADRAKKIVNHAIINEDPNAKVIRELRDEVEVLKSQISQTKERETEYEELKERLLESERLMEQMNKSWEDRLKETDVIYEERQKDLAQIGISVAEAGIKVEKDRFYLVNLNADPSLNELLVYYINKKAIIGSGNDSENEMPSSETRTSAPDEKVDFVLQGLGVHPRHAQLEIIEDFGLLPRLYIIPLFEGARICVNGSNISEKTLLKNGTRLLIGHNHFFRVNCPKDPKDENSLMLASTTMMEESQFFDYDKAWLEANSEEQGASISQAVDQYLEQINIKHQEEKQAALEKQYEEFERYIHGLTQTLQTPSTPMTPAGFGVAMTPIAGIAGTPSCGLPPVSFPTNPRNVDKTKFFKWAQKREEVFKESLKTLKTEIVSIKFSVSPNIAKCNALVREANMIADEIMSNKRGQTHYDVTLQIPASNLRPSRIKIGTSVCEPVIVVRRNGMQGYQLWSVEQLENKLIDMREMYNDKINGNNSNDQMGQSTSSTVISDSPTGNSGSSGICEDEDNDDGEEEEDSEGSLIDTFFESQEKHSLIGVANSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5L1</accession>
    <name>A0A914Z5L1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5L1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7634.t1">
        <property type="protein sequence ID" value="PSU_v2.g7634.t1"/>
        <property type="gene ID" value="PSU_v2.g7634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7634.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16788" checksum="0396AEACDE96D2FD" modified="2023-02-22" version="1">MALLDLAAMEENDEISSTAKSSLSLIASTSPKAVITAFATEVTRYNTIHQTTQITVISPLKSSKTDILRILEQMIENYFTDVIELIIPVCDILLHCLDLQLLKHQNFYDLFPPISKLHMIAYCPATKKLAIGGNNGVIVIHELKNMKSQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7I8</accession>
    <name>A0A914Z7I8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z7I8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8291.t1">
        <property type="protein sequence ID" value="PSU_v2.g8291.t1"/>
        <property type="gene ID" value="PSU_v2.g8291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="62"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8291.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16720" checksum="232FCB068DA122A1" modified="2023-02-22" version="1">MVAPEFTKSFKELLDAEGFKDYRIIKRDVQKDIDRSHWRSTVRKARRHRRKISSASEFSINEYHNYDAIVDYLNKITEEYSNLTMKFDIGDTFEGRKLVGIKIGSKVRKFKPAVFIDAGIHSREWIAPASALYLINKSNRNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z843</accession>
    <name>A0A914Z843_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z843"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8849.t1">
        <property type="protein sequence ID" value="PSU_v2.g8849.t1"/>
        <property type="gene ID" value="PSU_v2.g8849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8849.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14542" checksum="F09D2E4EC9A79B8E" modified="2023-02-22" version="1">MSRNIIATCGGMKDGTIKFWNLSTGELVTNVVAASKQTSAIVFDQHYGEMATTHGGNKNCINVWKYSAASSKFSLAHEIKCVNRPINMVKSACDGFVLVTNAAQQLEFFDLFKKDEEESLRKKHFGFNGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA34</accession>
    <name>A0A914ZA34_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylaminoimidazolesuccinocarboxamide synthase</fullName>
            <ecNumber evidence="2">6.3.2.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZA34"/>
    <dbReference type="WBParaSite" id="PSU_v2.g953.t1">
        <property type="protein sequence ID" value="PSU_v2.g953.t1"/>
        <property type="gene ID" value="PSU_v2.g953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="7">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g953.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16304" checksum="228630404974E4AE" modified="2023-02-22" version="1">MTDYFFKRLHAAGVPTHLVNLDLEKGTMEVRRGEPLGKGINGAGGFEFVCRTRPWGSFIRRYQQYIRDTEQKLDYLQLTRHVCRIVETDLSEKGLTLIDMKIEIGLVDGEIVVIDEISADAMRVMDDTGKVLEHSTVYERLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAJ8</accession>
    <name>A0A914ZAJ8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAJ8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9682.t1">
        <property type="protein sequence ID" value="PSU_v2.g9682.t1"/>
        <property type="gene ID" value="PSU_v2.g9682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="ESOPHAGEAL CANCER ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673:SF0">
        <property type="entry name" value="VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9682.t1"/>
        </source>
    </evidence>
    <sequence length="730" mass="84552" checksum="8B0D19CB189BCBF7" modified="2023-02-22" version="1">MKDYRKLLTFFWEQERRLDCISLIIEITRLLNSLSVPQYYPSIFVHVTDILDIFGNLVYQRLLEKAKLERSANHLPSLSQNFVTSDILEHTRITARNWFGKVQDIKEALPRIYVELSLLKCMKFMDDSSTTANIMRIGSLIRSLQHPLISSYARAYLCRISIRIDATDRAPHWLCINDWMQTYKVQPIRLLFPALQYIVQCVSYGAVTYNDLLPLWEYCSVGNHRSILLCSFVNGISKFYLTEHAMEITKLVTDAEEVTAEELICLGKNICAVQVEERYRKQILRFAWKCINRIIQIPGFLASINIWIEFVAKYFSSRELGIILDQVLRQISPNKAYENHYPILISILEKIMSNSSNLIDLFELDIFVRFIDLFRKDTIKREISSIILTLFVQRTRRGALNNLKLAYFIIDICKKFHDSVTIYSTEDEVNTVAMLVQNALDKFQLDSIDPERSLEFLVSCRAATMNIDKIQKYIILRMLSLTLDITRRSKFSTAQTAFLQSCIANLFISIPSLLNPIHRIKLYIQSGHVAVAAQAFLFIDVFLQAAIKDFNSSSLTSSNDFCDLSPFFLSLLVTKPDTFNEKRTAFLKLIKRYLQAVEKFSWPSTQIASNQKGKCILFALQTQLFRRKLYDRITVASIQNEQFKWIDRNNREQNIEAIDEGILLTVNLLLPILENEKSELLPLNLELVEIVGKFGGDEIIEDLAEMAKNCYKKCKKIPKLKNRLLAVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAL3</accession>
    <name>A0A914ZAL3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LapB rubredoxin metal binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZAL3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8809.t1">
        <property type="protein sequence ID" value="PSU_v2.g8809.t1"/>
        <property type="gene ID" value="PSU_v2.g8809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Zn_ribbon_LapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LapB rubredoxin metal binding" evidence="2">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8809.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15758" checksum="30FE121E721C637B" modified="2023-02-22" version="1">MLQTCYQQLGKTAEWAEFLQRAVEENTGADAELMLADIIEARDGSEAAQVYITRQLQRHPTMRVFHKLMDYHLNEAEEGRAKESLMVLRDMVGEKVRSKPRYRCQKCGFTAYTLYWHCPSCRAWSTIKPIRGLDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB29</accession>
    <name>A0A914ZB29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor plug domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB29"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7458.t1">
        <property type="protein sequence ID" value="PSU_v2.g7458.t1"/>
        <property type="gene ID" value="PSU_v2.g7458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="entry name" value="TonB-dependent receptor, beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="entry name" value="TonB-dependent receptor, plug domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="Beta-barrel_TonB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="TonB-dep_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF82">
        <property type="entry name" value="FCUA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="FERRICHROME IRON RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB-dependent receptor plug" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7458.t1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37051" checksum="A75B728587E92725" modified="2023-02-22" version="1">MDTPFSTVSYTEAFIRDRQAKDLTDVISATDPTVFSNGVTGAWSENYAIRGFASSTSDTTFNGLSGMAPYYRTSPEMFERIEVLKGPPPYSTACRRAARSVAASTWCPSVPAISRCYVSVPTSPPMRSSAPTWMWARRLGADKQFGIRFNGAYRDGDGAVGKQSKKVQLGSLALDWRGERARLSADLYSADDRVDGPARGGGLAPGVAIPRPPRGDTLINPDWAYVDSQDKGAMLRGELDISDTLMAYLAYGTSKTDYRYNGSISAQILNPAGDFTTVMGQLAFDIKKQSGDAGLRGSFRTGAVGHQWAANVTHYQHTQNDYGRRSVPGWDWTTNLYNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB78</accession>
    <name>A0A914ZB78_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB78"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7504.t1">
        <property type="protein sequence ID" value="PSU_v2.g7504.t1"/>
        <property type="gene ID" value="PSU_v2.g7504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7504.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17873" checksum="7608E9AA503164A4" modified="2023-02-22" version="1">MKHDFVIDQNELKKKFRQIQTSVHPDKYGLHDERVQKMADDHSSFANHAYKTLSDTRQRALYMLEISNVGESSPDPELAMQMMELNEEIEENDDVEELKTKLKEIEEHINDIVHTMSSHFEERKAEKAKKDLDRLRFYDRTKKLILKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB86</accession>
    <name>A0A914ZB86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9023.t1">
        <property type="protein sequence ID" value="PSU_v2.g9023.t1"/>
        <property type="gene ID" value="PSU_v2.g9023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF16">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="238"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9023.t1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56301" checksum="A569A644E7EE46A4" modified="2023-02-22" version="1">MATPATSGESLYDGESVADSDRSGPETALLTGKSFLLGHQSINRKLFKVEPKKETLKIGAAISPTLNNLSDSRLAFKVILPTYPYLTIYPSQGFLAPRKKVILNVTHDKMDGKKDSEIKAIISMLPPIQIVGFEVSNSPKTDNIDELLIFENGVTTLTVWTELLLTAVINPNSNPAPVLVAPNAPELKQTPQTFIFLIFPYFLWQWFLHYYFPEYLVPKIDADDFFGEGSLRADNEIIRDFEIFVDPKSVMEFKNGIKNGIDRASKSLENINFELGFNVEYLKSLNKSFEDFDWKQHERFLNTFKHYKTEIEGIDLHFLRHDFPLKKGQQKVPILLIHGFGSSFWDFYKIIPILANPSRFGYDFGSEGNQIVFDVIVPSLPGFGFSQAPTKPGLGSIQAGRILGKLMDRLGHEKYFIHGSSALGSQIATNLALIRPKNVRGIHLANPFMDFETNTVAKIKWFASKILKQDISDLKVPKNVDIFERPDSYGNTILLIRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB90</accession>
    <name>A0A914ZB90_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZB90"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9924.t1">
        <property type="protein sequence ID" value="PSU_v2.g9924.t1"/>
        <property type="gene ID" value="PSU_v2.g9924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9924.t1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40098" checksum="25DE233C8AA1926F" modified="2023-02-22" version="1">MSAEFGAPVDVIINPTSNAEGETIVNIPLGAVFKFLRDTGEWSKEDYVGPVLATKPHDSNDHLDIQLYNRRSIYNIKIKFYRNSGYHRTDNIIMMKTSDGTVYGLASNNDYYEQLNMLEEKLKEFVEAPISPSFNSSRTSSPLLLSNTDSTRNESYISDISSPLKPINIDNNFNPMGFYSPFQQNALPIKQEKEFKWHTKPCMIPASVYRRAAAPPKNASRASSVTPISMNTNDKLFSNLDAEKNWNYRSPQNITQINGSPVNKTPQNNSFDEFSQRSRLLSMATASNTSPNERMDAVTKLINFAFVEGNQRGKQNVEELKETLLGMSNNQLLNVLEDVLTKKPDVKNVLLEKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBE9</accession>
    <name>A0A914ZBE9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBE9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9633.t1">
        <property type="protein sequence ID" value="PSU_v2.g9633.t1"/>
        <property type="gene ID" value="PSU_v2.g9633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9633.t1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37026" checksum="1EE694DD3C53E7FB" modified="2023-02-22" version="1">MFLENFKDIDEFIDAFYGTFNSKNEEEDQRSLEEIQRYTIPKQISTNNKEINVVGIDLGTTRCCAAVNRKNGIQTVALENTGERLLPSYVAFDEKHIKCGQIVVYRLRNYSEASVFDIKRIIGRRFENLKVDESWTFEVCNDDGKIFIKTEGFNGDILKMTPEDISAELLKYIKHKTEEFQGQKLFEAVITVPAAFDEAQRKATIEAANLAGWETVQLLPEPVAAAFAYFIDRPIPENSTLLLFDLGGGTLDVCIFKISNGELNIISRSGDPNLGGRDFDSILINYFKEKLKNNYEIILSKSKQFKLMQICQEAKETLTVTNEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC68</accession>
    <name>A0A914ZC68_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC68"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9913.t1">
        <property type="protein sequence ID" value="PSU_v2.g9913.t1"/>
        <property type="gene ID" value="PSU_v2.g9913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF50">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="40"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9913.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23447" checksum="33A07D8FB0D46548" modified="2023-02-22" version="1">MLLKTFGNISLSAEAIIAKENKEIDKIFEPNYASGKLKVLLEKVDYVIESGDKCVIVSQWTSMLDIVEHHLKKKKLKLTEINGKIATKDRQERIDSFNQKNGGAQVMLLSLTAGGVGLNLIGGNHLFLLDLHWNPALEQQAFDRIYRVGQTKDVFIHKLICKNTVEQRVLEMQENKIQLAASVLEGAANKTNKLSVNDLKYLFGLAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XQS3</accession>
    <name>A0A914XQS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bardet-Biedl syndrome 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XQS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10357.t1">
        <property type="protein sequence ID" value="PSU_v2.g10357.t1"/>
        <property type="gene ID" value="PSU_v2.g10357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10357.t1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39022" checksum="98E68747A8DE5EA3" modified="2023-02-22" version="1">MLQNEPEILCEYALVCKAQIAKERGDAKTAVNSLIIALKHNPNSPRLLYLLGKSRYLQGEHSKAIECFKKALEYETNNWAQEVLMNCPSLDKCVDILVFLAKLCVQKNELVPAMEAFKRALNLEPENLDLIAELGLLYLKTGSDQKAFSWLGKALTYDATHVPSILAAATVLQKNNDFDVALTKYRVAAEKCEYNGPLWNNIGMCFYGKGKLVASIICLKKANYQCPLDPKVLFNLALVHRSMLQHASAYHFIASAINLQNKNVIFIMTIAVILSDLGDFTSARKAYKKALSLDPGNAMIRVNFALFEYRRGNLSDAAAIIQNVNAKNLGESPEAAEVANRINFLRSCLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSU4</accession>
    <name>A0A914XSU4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSU4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10344.t1">
        <property type="protein sequence ID" value="PSU_v2.g10344.t1"/>
        <property type="gene ID" value="PSU_v2.g10344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037219319" evidence="1">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="2">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10344.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14113" checksum="E21B145E5DA7E11F" modified="2023-02-22" version="1">MQALKCLLLILVVVSFVEAFPFIQRLRRQSGATKGSDALDISDARCNSEELLQIMTENISADVKQSRFKIMEAAEAQLGGNFNVVCANGDFSYITSTRLYCLTTLENIKCYAFLAEGKLDRRLLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT83</accession>
    <name>A0A914XT83_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phospholipase A-2-activating protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PLAP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XT83"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10172.t1">
        <property type="protein sequence ID" value="PSU_v2.g10172.t1"/>
        <property type="gene ID" value="PSU_v2.g10172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="321"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="419"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="567"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10172.t1"/>
        </source>
    </evidence>
    <sequence length="838" mass="92607" checksum="40D7A030B721C7EA" modified="2023-02-22" version="1">MSESNLLQGDVPDYRIAVAFEAHKSDVKQVLATSVNSLISCSRDDTIKQWGNNLYNPNATNLLSSYCPSPPMQVNSLAFVDYKGKCYIFGGRKDGSIVVYEGNNTVPFLLLKGHSHNVCCLHINKEYSFLVSGGWDHNAIIWSLDAIVAGSTTDYLTLVGHQHSVWAIDSFKDLPDSVLTGSADRTVKQWQGNQLLKTFELHKDVVRSIICFDGGNFVTGCNDGKIRCFNRDNEKCLGGVTTQSEEYIYSMIMVDFNDKKFLITAMETGSIEIYSYNSESRAKLDFRTSLQVPASSAWSVTMMENRDIVVGGSDGYIYVFTWTQERLANQSIMEVFDVRMAHFMAERGEIEQKMKEQEEQAFTVIKVTLDDSGASLDLKYQRGTDPNIAAEEFIRKNSIPMSYLNEIVQYIKANVPAAAKYEQEKALKRSGIPGSTSGKMVNGVSYDHVFDVKLDDGRPAKLPYNVGEDPRLAAQRFVEMYDLPVSKIHQIATILETQIPAIAGFSSGNADPFTGGASYTSTGGAPSNGGANYVDPLTGGGRYVPGSSTDQMPISSLPLDRKRPRGLLVPIPNIIKFTDLPPAKVALDKLVTSNAAQDSHTKLSDEQLAAVESIMTNPFCAVNDVHFEAFKRGLLWGIDELPPVIHTLSVGLLNEEFNSEMCGQYGHQLFERLINLTVSDPKINIAIFIMRSFANMAEHKTGRQLLQQDVSLICDLALKHVQNSNIKLQVASAAVLANMSLILWTNTEVDKVAELGPREDAVRSFIKAFESNFNFDIAQPALILLLQSMATVMWGDNSVISLSKNRNLLSYVNVIKDKVSDEGGKSLARDIIEMIHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTA8</accession>
    <name>A0A914XTA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTA8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11192.t1">
        <property type="protein sequence ID" value="PSU_v2.g11192.t1"/>
        <property type="gene ID" value="PSU_v2.g11192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11192.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18179" checksum="C897858CCF64394B" modified="2023-02-22" version="1">MAVTNVAELNALVERVKKAQREYASFTQEQVDKIFRAAALAAADARIPLAKMAVAESGMGIVEDKVIKNHFASEYIYNAYKDEKTCGVLSEDDTFGTITIAEPIGIICGIVPTTNPTSTAIFKSLISLKTRNAIIFSRTRVQKMPPTKRLISFCRLLSLPVLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUM9</accession>
    <name>A0A914XUM9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUM9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10237.t1">
        <property type="protein sequence ID" value="PSU_v2.g10237.t1"/>
        <property type="gene ID" value="PSU_v2.g10237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10237.t1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10106" checksum="D79A47BE79EA5500" modified="2023-02-22" version="1">MFEEIPKYILIVCVIIAAVGAIGGAAATYSAIKELSTTQFKVPCYIQPFISNEDSEGNTTSTNCCGRYQNLTSHDDVTCSSANLDFYGKRKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUP9</accession>
    <name>A0A914XUP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11670.t1">
        <property type="protein sequence ID" value="PSU_v2.g11670.t1"/>
        <property type="gene ID" value="PSU_v2.g11670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11670.t1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16098" checksum="674251EAE1F2439A" modified="2023-02-22" version="1">MALYQPPAHIVAEEFEMDIANACRPRHGQNYSKFWVCRCEEKDDQGRLRHTYEKLIVLYQTINSGAHQIQNDVELEFLQCPTCTCISPSLMKKQLHLKNPFINADDLRANFQIHLQTYRATHPRCFLAAHEVLDLDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW05</accession>
    <name>A0A914XW05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12113.t1">
        <property type="protein sequence ID" value="PSU_v2.g12113.t1"/>
        <property type="gene ID" value="PSU_v2.g12113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12113.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9545" checksum="1ACE80B9BEF31E20" modified="2023-02-22" version="1">MYDKSNGTNLPNAPTWLDSKLIYSIYNGSCPEKFKKDDSVCSREISKKTCELFPEYTKATFDPNSNPENGTCSVVPRETLIAAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW72</accession>
    <name>A0A914XW72_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW72"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12185.t1">
        <property type="protein sequence ID" value="PSU_v2.g12185.t1"/>
        <property type="gene ID" value="PSU_v2.g12185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF213">
        <property type="entry name" value="INSULIN LIKE GROWTH FACTOR BINDING PROTEIN ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12185.t1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23902" checksum="6DA1460D79637B76" modified="2023-02-22" version="1">MLRMRKHKGNAQKLFCNNIELTKVPSYWPTHYHKIILRNTSLTTLHKNSFRKFRKLEELRIEESYQLDVIDKYAFKGLHKLRVLSLSKNPNLSQIYKATFSGIGNENSLKIYIKNNKLQVIHGYAFKNVNNLRELSIEDECIIFSKHSLSSISILDFLSIQGACKIDAETFLNTTRVHNLHISSSNLNLTKKTFDGLSHVNHVRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWJ6</accession>
    <name>A0A914XWJ6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWJ6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11340.t1">
        <property type="protein sequence ID" value="PSU_v2.g11340.t1"/>
        <property type="gene ID" value="PSU_v2.g11340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11340.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7532" checksum="A69CDA7CB43D3AA7" modified="2023-02-22" version="1">MASDIRDIVARQREKMSKGSAGGLKKGGIMRKGGTNPSGNLKVQVVEEKKEHIIASDNEGKALKKVAANAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWM5</accession>
    <name>A0A914XWM5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWM5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10936.t1">
        <property type="protein sequence ID" value="PSU_v2.g10936.t1"/>
        <property type="gene ID" value="PSU_v2.g10936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10936.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14966" checksum="8AA23A22EA68028A" modified="2023-02-22" version="1">MSFWEHNTEILVLMQSMAQILAYSNSCINPILYGILSERFRTGLAIAVDKVLCLNEKDGGRYKRHAFTQSAFSRSVVPPHSSPSITKLCTPVEDLLPKHSSSKSNLIIPSVPEKATTVYMDFKTSDSEETQVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWP7</accession>
    <name>A0A914XWP7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Macrophage-expressed gene 1 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1019.t1">
        <property type="protein sequence ID" value="PSU_v2.g1019.t1"/>
        <property type="gene ID" value="PSU_v2.g1019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038023402" evidence="1">
        <location>
            <begin position="21"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="2">
        <location>
            <begin position="31"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1019.t1"/>
        </source>
    </evidence>
    <sequence length="689" mass="77744" checksum="620269C4862CCBA3" modified="2023-02-22" version="1">MNNFCLNLFILFLFSNLSSSFGTASEEHLSNVNFCLKSAKTIPNNLLNGRTLAGIVGYGWDDLQSVITKPVFVEEFKKCQAEPTGAFLLPDNIFATPILETSLDRMAEYFQSFNDFKETITNSFSASAGGGYAGFKASGTFSKKHQESKEKFSKYKSSLLQTKLVYRSFNLYQDSVGVLEGGFMDQIEQISNALSQNLTYQAKYLSEMIVKDFGTHYISSADTGAIIEQETFIDSNYAFTDATTLDSIRASAAASFGSYFHASTEGIHEVTTQNKQTLSKITKHSKIITNGGPDVNAVLSMSDNGTLQVNNLVSFNHDGDWLYQLVTPRNFPNINADNIFSVQTLLKNAIELYYKKNTIRGCMDMNAPNYNFQANVDDGTCKSNNDTYPFGGVFQTCVPLENSPKWRCDNFTQKNLFVGAQSCDEKYFEAVKLLDEVYHFEDRIVKESRKKCKHILFFKKCHNVDYDVIYKDSVSVKAFWCRKKVNVTMPSEKGAMFGGLFESGKPNEFTGEIGCPGTFQPYFLGRSITVCLSYQYERDHVYSIPIEKFFSCQSSSSEKTCSSNFTQHLAAVENSCDLFYCVRKQTYKHQKHPILKRPPYMLEKLAVSNYSTNTVRAMYKGTELFSIPFSMIFDEHFISQKSINGSSEDEIDINGYIDNIHEKVLIVTKNLTATVDETLENIRKINEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYE1</accession>
    <name>A0A914XYE1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pyruvate, water dikinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XYE1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12225.t1">
        <property type="protein sequence ID" value="PSU_v2.g12225.t1"/>
        <property type="gene ID" value="PSU_v2.g12225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030:SF1">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="10">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="9">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12225.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22429" checksum="1224B22DAD926283" modified="2023-02-22" version="1">MVYAPTQEHGKQVKIEDVPQEQRDIFSLTNEEVQELAKQAVQIEKHYGRPMDIEWAKDGHTGKLFIVQARPETVRSRGQVMERYTLHSQGKIIAEGRAIGHRIGAGPVKVIHDISEMNRIEPGDVLVTDMTDPDWEPIMKKASAIVTNRGGRTCHAAIIARELGIPAVVGCGDATERMKDGENVTVSVPKVIPVTSMRSCWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XYE5</accession>
    <name>A0A914XYE5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XYE5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10711.t1">
        <property type="protein sequence ID" value="PSU_v2.g10711.t1"/>
        <property type="gene ID" value="PSU_v2.g10711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10711.t1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31419" checksum="4BB6961FA2E4DBEB" modified="2023-02-22" version="1">MDTTLRILNTHNRSLLTNKKNGAEFVGFLIYQLLVAVRFLHQKKLRLVHRDIRPDNIYIIRSENDLTATVLKLGDIGSARQHSPSSDEVVNIFPPSYPYRAPEIILTDSYETSVDIWSIGCVLAELIIGRPTFQRRSSFNLIFDIVSTIGLTDSEISDLPDYLQIKVRKNPEKFKKNKINEMFDDFMLPNWDKQGINGGEFRHLLNRMLVYDPRRRSNADELLKVPIWGYLKKTVEPNIEAKSEFIEGYGEITEENSNWKSMFLKIYIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZ19</accession>
    <name>A0A914XZ19_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BRO1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XZ19"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12461.t1">
        <property type="protein sequence ID" value="PSU_v2.g12461.t1"/>
        <property type="gene ID" value="PSU_v2.g12461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="8"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12461.t1"/>
        </source>
    </evidence>
    <sequence length="774" mass="88904" checksum="1B016154B23BF2FD" modified="2023-02-22" version="1">MEGIPKVPMISPDMKIPDDPMPADWIPKLREYIFTHYNDDPSKFNEAFKELSVLRYHACRYSADTESICIMKRYYAQLQMMKSRFPMETNEPVSVSFAWSDRSCDMAVGAAYEDINYEICCIMYNIGAAHATIGMNETRSDEDSRKNAFSNFQCASWPFECLRDKLNASKFASSNFEPELLTFFSQILLVQAQECLIEKAIFDNRTNVIVSKLARYAAETYFELKIRLDQDTLSDYILNSKLKTWKRLCEAKAHFYEAIKRYYLGQQCCEDEKHGESVAHLAAALEQIKEAQKVVQKDKRESESMKQAISFALDIISQKEAKVRKENDFVYHDRVPKAEDLTQVEPVTKAKAMPFDPFKRDTCGDDLFAALLPANVLKGVSLYSEEKAKLKRGIIQSIEKKDTDLEQHLLSLQLSQLNLDQNLDEMRLPEELLQASAAFTAQPHALFDLLDQLNVVATKSSEAEIKLTDLRHRLLNVKCPQLEEDQGFKVISTKVNELMDHHIQARANNTELQKALASQSEQLKLLALPLTELAKNICDKVVNVSETPEGKRLREMVEKVEEMRKGRIQLFENFKDDLENDDITSKILAEKDFSMDSLFEKELKKHDKAVQIIEMNLNAQDKILNALTEANANFAECRRDIVENNEKRRSQCVSLITAYQVFSGVKEKTEAATTFYNQLFALINALDKSVTGMEDSFKGERERHEEQKRIIAEKTKLYRERTAMESSNEQQPSPTTAERRRPKLGDYMAFYRNKMAGSQPQTILNASDFKCSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0V5</accession>
    <name>A0A914Y0V5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y0V5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12854.t1">
        <property type="protein sequence ID" value="PSU_v2.g12854.t1"/>
        <property type="gene ID" value="PSU_v2.g12854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="107"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12854.t1"/>
        </source>
    </evidence>
    <sequence length="383" mass="42719" checksum="06AF094160542BB5" modified="2023-02-22" version="1">MVLRVVAHLSEDEEGGPKEIAVELDDFTLLFFETVIAELKAKLGIDSSAPFDYLEYEEDGYPCNVKTDEEIQSLSESPPEDPLHIWLKSSRHHHAISDDFILNSADFIMKQELATGQFGTVYLAEDIRHERLVAVKSIIANLEMAKMQQEVEILSELRDCPQIVQFFGAIFEDDHIKIILEYMDGLSLDKYEPLPIDVHGVASVAIINALSFLWSKSIIHRDIKPSNFLVNSNGDVKLADFGVSRTLEFSNAFTGVGTAIYLPPERIKGGAYSVSSDVWSLGLSLTEMALGSALWAAQNNSFNIVSDFSHHIIENLSKIFEEIGSIDFDLQALISGCLKPIPNDRLAFYDLKGTKFVKKYSFVNKKVVADFILSKQSVNAGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y158</accession>
    <name>A0A914Y158_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y158"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11570.t1">
        <property type="protein sequence ID" value="PSU_v2.g11570.t1"/>
        <property type="gene ID" value="PSU_v2.g11570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11570.t1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23348" checksum="03C6123731E6683B" modified="2023-02-22" version="1">MLSRTVGNVSALAFKTVQGQSRLRFLHASAVTFKDNSVIDQAKEKAQNIVDKAKETYESVKDKVEAQELTNKINETFENAKESVANAAKAVGGQNLAEKASCTVEQAKEMAQNLRSKIDGPNITESAKEMYEQVKDKAQDLKDSVMGGGPGSGTSPSASGKSSTYDPRGSQEDVAKLIHENKKEFSEFDKKHGGDGKYSGGGFDPVRFFFGLNIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y372</accession>
    <name>A0A914Y372_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y372"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13898.t1">
        <property type="protein sequence ID" value="PSU_v2.g13898.t1"/>
        <property type="gene ID" value="PSU_v2.g13898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13898.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9959" checksum="6D58153112B8B0F6" modified="2023-02-22" version="1">MALPHPPPPNALPEVPVKPLGPILSRSMVDIRMDIAELHSKGSRANSVIELTSTPSDAILIRTNQIDEELKFIDEAVEEEEEETADIFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3T0</accession>
    <name>A0A914Y3T0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3T0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12413.t1">
        <property type="protein sequence ID" value="PSU_v2.g12413.t1"/>
        <property type="gene ID" value="PSU_v2.g12413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12413.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8192" checksum="40D3619F173B46FA" modified="2023-02-22" version="1">MNLFEIPRQQEDNNAAEPEVMQFHANQQLLNPNQQNQGRESMEESDSTGEDDEGFVVVVTTSRKKEVWLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y443</accession>
    <name>A0A914Y443_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GB1/RHD3-type G domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y443"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13547.t1">
        <property type="protein sequence ID" value="PSU_v2.g13547.t1"/>
        <property type="gene ID" value="PSU_v2.g13547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13547.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40940" checksum="FE08860A60866BAD" modified="2023-02-22" version="1">MHKEQHPNEPWQLTQTTKLAGFEFREGEDRTTLGIWAWNRVFIIQQNDGKKVAVSLIDSQGTFDNHTTYQDCSTIFAMTCMFSSVMCFNVFTDLQEDKLNDLATFVDHAKKIVDNLGGNGKLFQDLAFIVRDCCFNKYLEDKNGGQKYIEKVLSEVKVQERQEVRDSLNASYERKFGFVFPHPGKQVALKKTSKISEMDSEFVEKTKEMVETLLSPAKLSIKQLGPVEFCCKDMCSYIPLCVQCFDENQEFAPQAVQTVNRDFVINKEVQRAIEKYIEFLEKVFVNCKTGYDQIKMDEFHMNAFTCVQNDILKRIKSKAINDEIMKIFVKQANNKYVHYFEKNQLLVEVRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y477</accession>
    <name>A0A914Y477_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y477"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15002.t1">
        <property type="protein sequence ID" value="PSU_v2.g15002.t1"/>
        <property type="gene ID" value="PSU_v2.g15002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15002.t1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12216" checksum="AF6ECCC718E125AA" modified="2023-02-22" version="1">MGYSWTRKAATNTVLCYRVMAADGLLGKKYARPRENAENKSEGEITADDEEVEDEDFDDDDIESGGSNTRVLPNNRSRQADTVASTATTSTAIEHHVPLVDEGTQTPINPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Q1</accession>
    <name>A0A914Y4Q1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="WBParaSite" id="PSU_v2.g14212.t1">
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        <property type="gene ID" value="PSU_v2.g14212"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14212.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10520" checksum="75E7BF7EF7CD59D4" modified="2023-02-22" version="1">MGGETTKTTAQKTTSRIAPTKVTKGGKDNKKYIRDEKCSVDIKRPGRSEEGAQPVSKGPARDEKFDKGGTGRSKSSAKSASVIFFFLSCLSTYVHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4Q2</accession>
    <name>A0A914Y4Q2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
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            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="WBParaSite" id="PSU_v2.g15174.t1">
        <property type="protein sequence ID" value="PSU_v2.g15174.t1"/>
        <property type="gene ID" value="PSU_v2.g15174"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
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    </dbReference>
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        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
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        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15174.t1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16155" checksum="3E2A0AD15161A2E5" modified="2023-02-22" version="1">MHEIEKLIGEMSKKFSTCVSYFGEDSVKASPDVFFGHFCKLLTQFNECQTFLWELREEEERQKRQTIAKSFFAKKQRRSPRNGGGGGNGNGGGASGNPRDPRNRDFEKLIDAIQSGDIFSEDLTRLRTSFRIPKRKSIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y536</accession>
    <name>A0A914Y536_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
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            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y536"/>
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        <property type="gene ID" value="PSU_v2.g13885"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037183878" evidence="2">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13885.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9495" checksum="796D8D92F012B9C9" modified="2023-02-22" version="1">MACFRSLLFLSALAFGIFISNAYGASLKSYDPYGVNKRLSTTPPPSNSPYQSNNGSDVGPMVKDDTDELQIEMVSFFFFLFERCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y595</accession>
    <name>A0A914Y595_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Vesicle-trafficking protein SEC22b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">SEC22 vesicle-trafficking protein homolog B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus</location>
            <location evidence="16">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y595"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13943.t1">
        <property type="protein sequence ID" value="PSU_v2.g13943.t1"/>
        <property type="gene ID" value="PSU_v2.g13943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
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    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="21">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="22">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13943.t1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24517" checksum="BAEEB773D7EEB761" modified="2023-02-22" version="1">MVLLTLVARVRDGLILATSIEGGDDPDHNMVKLTTQAKMLFKKLHQPNTPSVQSVESGAFVFHYLIKDSICALALCEQQFPRRVAFAYLEDIANEFLSQNAHKVDTVTRPYHFLDFDPYIQQAKRKYMDRNRQAMAAVNSELQDVTRIMVSNIEDVLHRGEALTMLDSRAADLRDLSQKYREDARKLNNKSAMKIMIAVGVSLILFVLLRFFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5T7</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
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    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="term" value="P:lipid catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14125.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9672" checksum="F7A298F939BD3A73" modified="2023-02-22" version="1">MVFKFDVLFFVVVFFVGKPLTNFIDTYIAAAGVAYGLEKCTPTYHACNVNNGMYCGSDYMKDLNRQQERYEKNIHILFTVILIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y646</accession>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <property type="gene ID" value="PSU_v2.g14914"/>
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    </dbReference>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14914.t1"/>
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</entry>
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    <accession>A0A914Y6Q0</accession>
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            </authorList>
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    </reference>
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        <property type="gene ID" value="PSU_v2.g14433"/>
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    </dbReference>
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        <property type="entry name" value="SSL_N"/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14433.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8058" checksum="2C8BE15DC88484EB" modified="2023-02-22" version="1">MYKIAILAVALGYLIHYQMPKEWEKLKFEIIELKAPPAHTGPLQKNDALENAEILFKNDMIGPESIIQFM</sequence>
</entry>
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    <accession>A0A914Y6U2</accession>
    <name>A0A914Y6U2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Panagrolaimidae</taxon>
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    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
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    </reference>
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    <dbReference type="WBParaSite" id="PSU_v2.g15166.t1">
        <property type="protein sequence ID" value="PSU_v2.g15166.t1"/>
        <property type="gene ID" value="PSU_v2.g15166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15166.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18102" checksum="D92BB058357AA47F" modified="2023-02-22" version="1">MVEKDTVKPRPSLKHIKKEIDQRFSSGSSIPHQSSPTSDDDNQREATPDATTDETPLKGTSYSLENITKGEAPKNSRNSKEIFEIALAAQRNLHAASARLFRTVHYDEQSRIRQNKLAEELLSSLKSKLVHEEAEAKAKAELATLRLQQEHSKVNKSATNTP</sequence>
</entry>
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    <accession>A0A914Y7B7</accession>
    <name>A0A914Y7B7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
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    </reference>
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        <property type="protein sequence ID" value="PSU_v2.g16097.t1"/>
        <property type="gene ID" value="PSU_v2.g16097"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="115"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16097.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24374" checksum="4452E90F3DE2E2BD" modified="2023-02-22" version="1">METTMIKKLLTSTLPPPPPTTTEAASFFVENGLLLIIIASIIIIILILILLIFCCCCTSNNSDGKNDSKQQIQSILPIHQPPPPRSSSSLPPQTTETRTEAMIYANAKGQPILKTYKVSTRSTSSGESGGRAKRTKSTRASTAAAATTTAASSTAAAASNRQQQRQHRRQQQQQHRHRNQKIDNTNNPFHDEEAPLDTVSAPRKVTSDYYERHGIPQYSSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7H4</accession>
    <name>A0A914Y7H4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7H4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16157.t1">
        <property type="protein sequence ID" value="PSU_v2.g16157.t1"/>
        <property type="gene ID" value="PSU_v2.g16157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16157.t1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29098" checksum="9D83443090B53B3A" modified="2023-02-22" version="1">MPILMYVQLQQNALLNLQKFKEKKILLRDPLIETIDAVYASSNIEVISDEVAAALGKPNPNIKIQTNLFLYRVFKTFNAQTAPKKVVKALTPLIAKCTGESDAEAREASFAALGAIMKAIGKANAMTMLGDVSNDKTKMERIEKFYNQAVEEAGVEVVSEMVQSMHKSADTPAAEKPPSGPKVVKPKGKPKSVEEQPDEEEEPLRPMGKQDDDEKAIKGRSASKNNRRSVAPAPPKSPEPVEPSGVLSSASNRNARIKDEKNLKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7R9</accession>
    <name>A0A914Y7R9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7R9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1532.t1">
        <property type="protein sequence ID" value="PSU_v2.g1532.t1"/>
        <property type="gene ID" value="PSU_v2.g1532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31936">
        <property type="entry name" value="PROTEIN CBG18744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31936:SF7">
        <property type="entry name" value="SHK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037340785" evidence="1">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1532.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="29244" checksum="05DB500B529A07CA" modified="2023-02-22" version="1">MSYPILCTLSFMFLVANAQKCGTCVDLEVDCGIETNGLLNGVVQVIYGNDGKGCRTMQVNCSDDLISGDPSALAITTINDGDMSLTPETIVTCNEDGSWFGKGVNNLVCQISRNIGGNEPIESATCKKSNVIRQKRAIPEASGCFSQWSNWVTAVPCQDYCGGCFNSTYTRTCLTTATCQCTGPSTLSKACNQNVCGYPRRSCCGSLKALSSHSVLVCSLPELANLPEEYPDTITICPPEGIWGSWAETCNSTCGGYGIGTRRRACLTAAAGCNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8T4</accession>
    <name>A0A914Y8T4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8T4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13990.t1">
        <property type="protein sequence ID" value="PSU_v2.g13990.t1"/>
        <property type="gene ID" value="PSU_v2.g13990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13990.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8977" checksum="E31941EED94FC382" modified="2023-02-22" version="1">MEYSTKESEIGKSLSKFEDNADEDMEEDEDEEDAKFLVEYFKKRFLLKRNRLNNAKNDMPSSDEENDPNSIEQMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y970</accession>
    <name>A0A914Y970_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VWFD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y970"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15820.t1">
        <property type="protein sequence ID" value="PSU_v2.g15820.t1"/>
        <property type="gene ID" value="PSU_v2.g15820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF3">
        <property type="entry name" value="TENECTIN ISOFORM 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="67"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="6">
        <location>
            <begin position="180"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15820.t1"/>
        </source>
    </evidence>
    <sequence length="485" mass="56282" checksum="2EB79D4629AABF2F" modified="2023-02-22" version="1">MEKCSRSVLCHVLQRIWYHCYRLACPVLDCPNNLIKHFGNKCCPECIHPNSPREYRTILPENPRLQGYCTFQLRRYQLGEIFHLDPCTRCHCQPGGIQCRRFTCPIRQCQISAKLLFRTNICCPFCQYTVTAPTIMERKNETLSNFEEFRSERIDKQISYRNESGGKITTCIHKLPNDESTCTVSKNSQYQTFDGLNYTFHGNKSYVLTQECGFDDNNNDNEDDIIDGDEQPNFAVIAHNSQNEKDEIITRRISIIIKIQNSQRPLILQLAKNKSFTENDKPINIPINTSIYSIEDLSKYTQISIPLLGLKLKFDGQGFAELILSTMHKGKVCGLCGNYNDRENDDMWPKYADSITENIEHFGASWKFIPRKTAKTSHRCKTSKLTAEKAQDLSECRRLLDNKFFAFCRKQIHVHQYIRQCTKDVCECSSNATKIANEKPCYCHSIEAFATQCANRFIWGQWTQILQNVRQFPVHPKCDKIRRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9S9</accession>
    <name>A0A914Y9S9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Acyl-CoA oxidase/dehydrogenase middle domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y9S9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14287.t1">
        <property type="protein sequence ID" value="PSU_v2.g14287.t1"/>
        <property type="gene ID" value="PSU_v2.g14287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="11">
        <location>
            <begin position="169"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14287.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33079" checksum="2BA59815953B39C3" modified="2023-02-22" version="1">MIPTILNNADEEQKAEWLPKAQNLEFIGTYAQTELGHGTNLRSLETTATYDPKSQEFILHSPTTSATKWWPGNLGKVANVTVVVARLIIGGKNYGPHPFFVPIRDPTTHQSLPGIILGDIGPKFGINTVSNGFLIFDNFRIPRRNMFMKNARLEADGTYISPKHAKLAYGTMVYVRATMIRTMSNLLGRAATIAIRYSVIRKQGEIEAGKGEVQIIEYQTQQYRLLPQVARAWAYEFAGRYTRKLYEQFLAGDFEVLPALHGITSGLKAVVTHQTALGIEQCRMACEITGPKIVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9U4</accession>
    <name>A0A914Y9U4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9U4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16204.t1">
        <property type="protein sequence ID" value="PSU_v2.g16204.t1"/>
        <property type="gene ID" value="PSU_v2.g16204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16204.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15662" checksum="7DF34DC141D5B535" modified="2023-02-22" version="1">MTETVHPEKSPSPFLSVFRKKRPSPAISAPGDYTNGTASTPPPPVKPPKSPKSPQMSFTQRVKMHKDLRSGKIPDFFVQSSQSQIIPSTSMAPFPIFKKGEKKSEKLKKNKALSADAINHMDPNYLTEALEAFGDEQPIVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YA50</accession>
    <name>A0A914YA50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YA50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16309.t1">
        <property type="protein sequence ID" value="PSU_v2.g16309.t1"/>
        <property type="gene ID" value="PSU_v2.g16309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16309.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="17026" checksum="C32300C7933DC113" modified="2023-02-22" version="1">MLGLVVAIFMICWAPYQLYHLFLERLLNDFIIASYTYMVFYWMAMSACVYNPIIYCYFNVRFRIGFRYAFRWLPFFNFQLNEREYSQLFPDAARMITSSTALKTDISKNRLYSQRNTLVGSKSSNSILLTDFTQRDLTTSQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB36</accession>
    <name>A0A914YB36_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB36"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16628.t1">
        <property type="protein sequence ID" value="PSU_v2.g16628.t1"/>
        <property type="gene ID" value="PSU_v2.g16628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16628.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22478" checksum="6EA9964C010A714D" modified="2023-02-22" version="1">MPSLNRILSETAKYFVELDCVPFIPGTVNIKSKESTKDDAFTVLQFRVDHFVDIMLFAKSVAAKICSSLNVHRCAMIAGVDCNKSPGVKVIPLHGLSSEWNALLAGNLEENDYIELLKASHRVANLLIQGIPNANSCGLMFEGFEIDYAHSKVIPIIGDPTTVCTDTDFCETYQGYISSKSGKMLTEDEIKALAKKLDWTALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBH4</accession>
    <name>A0A914YBH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBH4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17554.t1">
        <property type="protein sequence ID" value="PSU_v2.g17554.t1"/>
        <property type="gene ID" value="PSU_v2.g17554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17554.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15772" checksum="CABBE82F5A9A9599" modified="2023-02-22" version="1">MEVSYDDEEEDGGEEEEKAPRRKSKSKSRAREREREEEEVAAAAAAPSEKDEEESEPLKDNNEEEEENDGKKDEQKEATTQHYIFERPTIAPVPEEDSNITIISVFLLIIVGIILSGIVYKLELHKKLFRSSYDTVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBT2</accession>
    <name>A0A914YBT2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBT2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17661.t1">
        <property type="protein sequence ID" value="PSU_v2.g17661.t1"/>
        <property type="gene ID" value="PSU_v2.g17661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17661.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="13910" checksum="FF2727ED3D5EAC93" modified="2023-02-22" version="1">MHIARRAVTCPEDHEVVVVTLVEQIVYRELGIPMLVHAVIGVQANQGIAAVGVFQRLAVAGRIRTASRPQITLAKPVHGGAGAQALQRTGELVHGAQTEGLAGNVGVDPLAFTVFSAGVAIRSKHIPVVGQCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC42</accession>
    <name>A0A914YC42_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YC42"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17000.t1">
        <property type="protein sequence ID" value="PSU_v2.g17000.t1"/>
        <property type="gene ID" value="PSU_v2.g17000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17000.t1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14730" checksum="7637AA7B5A5214B2" modified="2023-02-22" version="1">MDTQPRSGRLQSAGSNRVCGPFHGNCGPEDQPQGIARPTARTTRKHNARIIMSTALTLERMRADIAAMLHEDPQDILDDDNLIDLGLDSMRVMTLATRWRETGAPIEFSEMASVVTLGQWWSLIERAQQNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCE2</accession>
    <name>A0A914YCE2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCE2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16966.t1">
        <property type="protein sequence ID" value="PSU_v2.g16966.t1"/>
        <property type="gene ID" value="PSU_v2.g16966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF181">
        <property type="entry name" value="OPTOMOTOR-BLIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16966.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12934" checksum="510DA45F17859240" modified="2023-02-22" version="1">MFPAFKVKFKGLDKASKYLIALDIIPVDSNRYKFHNSKWMIAGTGDPEMPKPINVHPESLATGEHWMTKGANFHKIKVTNNITDRHGYVSPFPKGPVGAMLVISIYIYIYTYCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCE7</accession>
    <name>A0A914YCE7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone RNA hairpin-binding protein RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YCE7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16970.t1">
        <property type="protein sequence ID" value="PSU_v2.g16970.t1"/>
        <property type="gene ID" value="PSU_v2.g16970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1120:FF:000001">
        <property type="entry name" value="Histone RNA hairpin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="4">
        <location>
            <begin position="248"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16970.t1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46854" checksum="A0BCDDAB6326315D" modified="2023-02-22" version="1">MSPTKKMRTPTKRNPNDLGIGSKSPITKAKLLASPRKGRQLTFDDINSIVQQNANKSWNDMMDEGSNEADKQPQPPPKTDDLLVIEETPVPTVISQEWMTISEANVAVSSPQRSSRKSAAPQKSDTKPKFIKSLELNNVLLARRSERLKKNKEEKVSPEKSIRQQRKRRMSIESTVTIESSASPSRRGRQIPTKTAKIQQQPTTPSRTSSRCGSTFSTPSRQRLDSAMTDSPNPRDEWEQPKLGWCYDEALLSRRSKDLEKAKEKDVYQRYASEVPRALRKNGIHPKTPNKYINYSRRSWDSQIRAWKRKLYDWAGLSPSTSVVNSLESSICDPQDILQRNREEEYENENPSRLIATAAAKIGTSDPVYNPDQMASLLGHFDMHTRGGGEESTLKAPTNSNQKGPVDFSGIDTADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCG5</accession>
    <name>A0A914YCG5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7TM GPCR serpentine receptor class x (Srx) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCG5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16448.t1">
        <property type="protein sequence ID" value="PSU_v2.g16448.t1"/>
        <property type="gene ID" value="PSU_v2.g16448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051119">
        <property type="entry name" value="Nematode_SR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31627">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16448.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17901" checksum="CB79E49F243AA332" modified="2023-02-22" version="1">MNCSRFTIYLVTGTASISLLFNLYVIVRLIKDKFTVASNVQKKTSKQDIKLSIYAMVVFVSDMIYVVQQYIRRLSNDEKFIDVMFDVQNAIADIGCLTPIWFIILTNKNLRKNVIATFFWLKSDLIQISAVKPFNSKASGIGKSSNRQNAISTGITLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCH9</accession>
    <name>A0A914YCH9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CXXC-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCH9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17941.t1">
        <property type="protein sequence ID" value="PSU_v2.g17941.t1"/>
        <property type="gene ID" value="PSU_v2.g17941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="6">
        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17941.t1"/>
        </source>
    </evidence>
    <sequence length="445" mass="49282" checksum="185A4C4B859C3CDD" modified="2023-02-22" version="1">MSTLTSVGPMIINGMQQPGQPGVPMMAPNQIALSAQYLAPNGSPFSHHMPTNNNNYRTPQLAMPGSSSAPTPTTTTTAAINRSQRCGVCRGCQCKPCGTCTYCQDSPQFGGPGVKKQSCIERRCLRVLENRLQRDAPTFKARVGCNNCDDCRMADCQVCLVCLDKRFFDNRYMTGALCGKKRCNNATSLELPSQQHQQQQQSQQQQQQQQQQNSDRQMMKRSFDATGQNGYDYVMAKRRGMEIPQPVSLPPPPPNGVQIGQPRVMMQGNNGVTLDANGYAQPPSLIRLIPQHQQMQPQLGPHMSLLVPMSSISNSEAQQLPPQSQPQQPPPQPQQQQQQMNGDNNGHSSSNGQTIQINGTNGPTVVTIPHSMGIQNMPQPLPQQNGIYPHFIQNGMINSPYDYQKMYAYPKYEYYDCDPNRSPQDPYVPPSYSGEAKNEIILQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDK4</accession>
    <name>A0A914YDK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDK4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15522.t1">
        <property type="protein sequence ID" value="PSU_v2.g15522.t1"/>
        <property type="gene ID" value="PSU_v2.g15522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15522.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12965" checksum="B3D9E9293C3E9FAB" modified="2023-02-22" version="1">MNLYESLNNPHYLQNHMQDREIQRHVAGTFVVLRVEDYVPVFGCIDGYDRNNSMFTVNVYRTITFEAARHCYEVLRTENVIIVSCSDFQIPDVLELYFDKYIRLPYCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE61</accession>
    <name>A0A914YE61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YE61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17722.t1">
        <property type="protein sequence ID" value="PSU_v2.g17722.t1"/>
        <property type="gene ID" value="PSU_v2.g17722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036872187" evidence="2">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17722.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="19195" checksum="655D9AF95ADB4760" modified="2023-02-22" version="1">MGVALVAILLAIPRPTVKASKGKPLPFRAVLGRVWLYGMALALASAGFGVIATFITLFYDAKGWDGAAFALTLFSCAFVDNRPATGWRGDYAVDGENRRLTGGGRVFAGVPGIGCSGGKSGSAAKSGGGAGNLHRIYGFIAWRDWTTGWAGDELGGRTGDLSGGGGTGRNRVITDVAIKKTASGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE80</accession>
    <name>A0A914YE80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YE80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17064.t1">
        <property type="protein sequence ID" value="PSU_v2.g17064.t1"/>
        <property type="gene ID" value="PSU_v2.g17064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF472">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17064.t1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22933" checksum="689F169F73C7273D" modified="2023-02-22" version="1">MVTLADFQFTKEVGRGAYGVVHEVKRKATNEVFAMKVINFNITGDGVPQSVIREMGALMAVKKYNHRNIVKLYEVFINQTLTHNNLYILYEKCDWDLHHFLENIPRNMNESQCQWFAHQIFCGLEFLHENGIVHRDIKPQNLLVNKDQTIKIADFGLARNISLHASFTTTVVTLWYRSPELLLQCAYNSSVDIWAAGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YE93</accession>
    <name>A0A914YE93_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Globin family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YE93"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18576.t1">
        <property type="protein sequence ID" value="PSU_v2.g18576.t1"/>
        <property type="gene ID" value="PSU_v2.g18576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF6">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="95"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18576.t1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32884" checksum="5E90E73287E6CD5E" modified="2023-02-22" version="1">MFHTHESIDVPTHLLSEESSADDETNQSGIKRSKLAQDLTNKLLTKTLSNVSAISSSTGSKITDDALNLNYVPLAQAHWILLGKSKDQIGLCRSMFNYVIINYPHTRPMWQFVKDVNFENDEWKESLQKDNRFKHHCASVQTAIKIVMDHISDYHQMTKLLRDIGCHHFFYDAYEPHLELMHEGFIHALSATIMDSGMDEDLKNGWNQIWQILKKHIGQGIAIQRQNYMTECVTKAEISNVKAQWEKIIEEYGIKEAGEAVTKEAMIVCFFLFLFHTFKYKRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG14</accession>
    <name>A0A914YG14_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG14"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1924.t1">
        <property type="protein sequence ID" value="PSU_v2.g1924.t1"/>
        <property type="gene ID" value="PSU_v2.g1924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1924.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19315" checksum="812A293CBA5C0A9E" modified="2023-02-22" version="1">MDKWTNEQNTAGGLGGFVIVCIILFCIYRLLKYCQSNRDQPHPTSNYERVTEIVVQQRRVKICKLPPIFGPNAYLFTVMDNLDRGVRHVFVRHERDFSTSKRSNQNDVIKQLRKNLTAENFIAAEEDPRGNRYIWKTKDRNGVPKELVTILSPRGKGFELITAFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG33</accession>
    <name>A0A914YG33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG33"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18407.t1">
        <property type="protein sequence ID" value="PSU_v2.g18407.t1"/>
        <property type="gene ID" value="PSU_v2.g18407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18407.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="19391" checksum="F79A81DEC580F1F6" modified="2023-02-22" version="1">MNEYMLEFLFNLYKERRHFGFTFSKLDSILRKNYPRYFEELEERRQQSSAVVDRRPPSSQHGRNDTEFRSSRQDNYQPRNDRPQRFEQQQSHSQTCNDSQQRNYRNENFNSQNARDNNYRGSFENRAPTQQNSQRNGTTNNGGRDFYNSNGSYRSNNNGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGR3</accession>
    <name>A0A914YGR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18516.t1">
        <property type="protein sequence ID" value="PSU_v2.g18516.t1"/>
        <property type="gene ID" value="PSU_v2.g18516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18516.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18127" checksum="3CC0FA4267290AC4" modified="2023-02-22" version="1">MDEQDLPDELLKYTKREYFPLVYALQALISRNGAIYDYFFRPCFNKFDEFLNLVTDKYENNLVDDPDAKVTKTVIALEHMLQLIDRLLDTPEPISTFQSLYDAPGYRMLAEVTSDLDKKGYMRVRKVVITPTRKIFANPELIMGNRSLRQKGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGS6</accession>
    <name>A0A914YGS6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGS6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17995.t1">
        <property type="protein sequence ID" value="PSU_v2.g17995.t1"/>
        <property type="gene ID" value="PSU_v2.g17995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF16">
        <property type="entry name" value="GLOBIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="107"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17995.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="30870" checksum="B32997E80824C4A9" modified="2023-02-22" version="1">MKEVRRQRIMDEIELKDTKILPPTSLLSPSNNGYPSLRDVGRSKTDPGGGAESEGATPTVPTKAVISGFSFDSTKLSAQLSDIAFKRSNPDLSIDGIKQRTLRDIIGITVYQAKLLLQCWPNIYSTGTSGPFASQLYSSLGKRNPKAKTILTKANGVAVFSQSDIDCTSMHTKLTLELIDTIIRTLDNSPTNIINYLTEIGQCHRTLKDEGMSTAMWDDLGDAILEGVRKNDLVRKHKECRRAWLAIIAFITDNIKQGHNTFKASPSTNDINERNKEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGV7</accession>
    <name>A0A914YGV7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGV7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19541.t1">
        <property type="protein sequence ID" value="PSU_v2.g19541.t1"/>
        <property type="gene ID" value="PSU_v2.g19541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19541.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19163" checksum="07F83D976CAF9A57" modified="2023-02-22" version="1">MVEATDQFGVLLHPPDLGHDADVFMAQFALGSDRLLVVQHFRVVLGQVQRLGHVLDAVSLGTDAGAAVEGLHPAFETGGTVEHVGHEPDHEQDRDPRTEHHDHAGEGDVVIVAPQVVGDQAEDQQRGRLPADDRGDQPLALGLGQHSHFIADLLLAEAAPVRDLFFERAAVELVVAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIL9</accession>
    <name>A0A914YIL9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIL9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20190.t1">
        <property type="protein sequence ID" value="PSU_v2.g20190.t1"/>
        <property type="gene ID" value="PSU_v2.g20190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF81">
        <property type="entry name" value="FLAGELLUM-SPECIFIC ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="9">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20190.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15911" checksum="0CB025A5F4793C6A" modified="2023-02-22" version="1">MAGVSINPLAREPITQPLDVGVRAINALLPIGRGQRVGLFAGSGVGKSTLLGMMTRYTDADVIVVGLIGERGREVRDFVETTLGEEGLRRAVVVASPSDRPPLARLHGAYRATAIAEWFRDQGLNVLLLMDSLTRLRPGAARDRLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIR3</accession>
    <name>A0A914YIR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g20229.t1">
        <property type="protein sequence ID" value="PSU_v2.g20229.t1"/>
        <property type="gene ID" value="PSU_v2.g20229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20229.t1"/>
        </source>
    </evidence>
    <sequence length="529" mass="54813" checksum="229596160158C9DE" modified="2023-02-22" version="1">MLGELHVRLQLGPAVGPGPAALHLRDGHVRILAAVQGLAQQRHLTRGARAVVTARHIATDRKAVVPLSLRIQAERVATQAGARTAIVQARIQPFVAGRCTQHHVFTQLPVHARHHRIAVGTDHITVAIAILLEHLAAAGQPGRGALATHGRQLTAQALADALFQVVVVQQRRATGRVHFTGELVERAARSAGVIHQHRVVQAQRRTTLRQAVQRRSSVVLVARVGHGGERCGLRHVDLQVGRVGGVDRGDGQEGRRRGCRGELPTHATACIDHRVLLALLVAGARRNGVHLHRAASHVGAAAHLHRVAAAGAQINAQRAARRQGQVATHRDRAGAIACAAAVARAIARRQHAAAGHRHAAAGATNGAGAGQRGTTADGPLAADGAGDIQATTGDLAGAAETTTVAAEIQATRAGLHDAAAAADAAAQCGGAAGVDHQATVVGDVAGDRAAGPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAAADGAAHRGVATHVEHQAAVVADVAACHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJA3</accession>
    <name>A0A914YJA3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YJA3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19392.t1">
        <property type="protein sequence ID" value="PSU_v2.g19392.t1"/>
        <property type="gene ID" value="PSU_v2.g19392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="61"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19392.t1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34275" checksum="E650AC3BE13B4206" modified="2023-02-22" version="1">MKLPIYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGLRNRLWNGIKDIEEVYLNGDLEHVADYGAERPRGFFRFRLYVSKPRTVLRAARAGAERRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-06-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKF8</accession>
    <name>A0A914YKF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g20826.t1">
        <property type="protein sequence ID" value="PSU_v2.g20826.t1"/>
        <property type="gene ID" value="PSU_v2.g20826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037931220" evidence="1">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20826.t1"/>
        </source>
    </evidence>
    <sequence length="121" mass="12601" checksum="FE5F601A44F0E702" modified="2023-02-22" version="1">MIKRLPIDPFLLKLFATVALASLLPAQGWAASVPTHHADRDCPAVLSAWCSSVTRGHLGRLVSLALAPADSVRHLCAXPYSGQWRGGCAASLANRQSVPGNSVSGLPAQHRAICGGADRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKJ1</accession>
    <name>A0A914YKJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19861.t1">
        <property type="protein sequence ID" value="PSU_v2.g19861.t1"/>
        <property type="gene ID" value="PSU_v2.g19861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF8">
        <property type="entry name" value="SLO-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19861.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9019" checksum="146BF1C76C4D17F2" modified="2023-02-22" version="1">MDTLGELNGVDYHLIYEEITLKRSKNGKRLGLTLCYGNNDEYETDIFVSEIEKASIADIDGRIKVGDQILQVSLLTVNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2024-03-27" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKX6</accession>
    <name>A0A914YKX6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="WBParaSite" id="PSU_v2.g2.t1">
        <property type="protein sequence ID" value="PSU_v2.g2.t1"/>
        <property type="gene ID" value="PSU_v2.g2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021010">
        <property type="entry name" value="Cytosolic_motility_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578:SF3">
        <property type="entry name" value="NEMATODE SPECIFIC PEPTIDE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31578">
        <property type="entry name" value="PROTEIN CBG21223-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12150">
        <property type="entry name" value="MFP2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141739">
        <property type="entry name" value="MFPT repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22996" checksum="0DAB221A1C960BFE" modified="2023-02-22" version="1">MYVALWYKHGKPIHGRAWNNGGVVECSFPYLKAELTGAKDLGGQIQILQYKGDHNTLGYWYEWIKYKDRFEKSEERQLVKCGDSLPIFWKDRKGGPLGGFLDNKTEEARFSHDGVAENLTGTVLSDMWIIVRNFKGGPPFCECWKHGGSCPKPPPTPAPGPRVMLNEWMDIRAGDPFPTHPLVKALNQSLNTIXXXXXHHFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLH4</accession>
    <name>A0A914YLH4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLH4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2040.t1">
        <property type="protein sequence ID" value="PSU_v2.g2040.t1"/>
        <property type="gene ID" value="PSU_v2.g2040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2040.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28040" checksum="8A0A4298E1E72513" modified="2023-02-22" version="1">MNAEFEKRFADKDQLSIEQWQAALPTMNERKEIGTLIDFLMTLSTFENLSSSKLLSYYQNINKSINITFYKTEYAIIHEIYNPYDSLPFKRYFGYTVIASRTIASKPYLHHGAPHFGFDGNVCNQSAEIFEQSFGRTLVVAGAHRYAVRDRTPPNPCQSNFAIADPAHNNLTMFHAFNEAILSASKRQSEFHLIPYFFIQWHGMSEESCPNSPVFISTGASGNDSIYLNSSLAANKAILFQIQSIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMK2</accession>
    <name>A0A914YMK2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMK2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20154.t1">
        <property type="protein sequence ID" value="PSU_v2.g20154.t1"/>
        <property type="gene ID" value="PSU_v2.g20154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20154.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21305" checksum="0EC896C027FC5D43" modified="2023-02-22" version="1">MVNLLTEVLTKKETKPKPKPEKESFESLYSRSTKSFKDALDADDKDVIPKLEVIQMYKNAMTLLNKAIHYVPSPVPKNNREQVDQQFELMQEWYKFTQRRLDEFKKDDAKEHNNSDAPSFQQKSPGSAKKTGVAALFATKEEQEILGCIILSTNIKLDDVLGNEAAKLALQETNSSKGYFIIWTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNU3</accession>
    <name>A0A914YNU3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNU3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19023.t1">
        <property type="protein sequence ID" value="PSU_v2.g19023.t1"/>
        <property type="gene ID" value="PSU_v2.g19023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19023.t1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36287" checksum="B166034F937AD713" modified="2023-02-22" version="1">MSSSTPREYTVRAEYRFYFIDESGIARFSNVNVGDFKVKPQKGSHSWGLRNIPKAKVQPCLRQDGSLQIVCQIELLPEVNRLRTLELVPGNGIDSNAVSKSYLNNIDAMRDDESVDCKIMCQGREFEAHKFLLCSHSQVFKAMFKHDTIERQESKINITDTTAKAIEHMLHYLYSSKLSETFPYEDAADVIQLADKYDMEPLKILVQRRLADQLNVSNLCDIFHIAHLHNADQLMESCIPVAVINSTTLIESDEFKSLKKHYPEVANQLLEKVVTYKGESNRTSNPYTPPNKRLRLTDLNRSFNAGLNAHNRFVFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP01</accession>
    <name>A0A914YP01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YP01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2580.t1">
        <property type="protein sequence ID" value="PSU_v2.g2580.t1"/>
        <property type="gene ID" value="PSU_v2.g2580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2580.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10178" checksum="8DECE23455F241F9" modified="2023-02-22" version="1">MRSTRDRRLMSLEGNNNNNNNNSGAVTNNSRQNGNFVTRSWARISGRRKKQPRPPPIEEGVEISEEQIPSTSSSQQIPWKLAHHEEKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPR0</accession>
    <name>A0A914YPR0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPR0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19343.t1">
        <property type="protein sequence ID" value="PSU_v2.g19343.t1"/>
        <property type="gene ID" value="PSU_v2.g19343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19343.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19129" checksum="8D096AFDC005FE50" modified="2023-02-22" version="1">MLLSQIMLGNYDEIKGVLMNKNALKYSSPHLDAMIAISEAAKKRSMSQFNVAFEKYKEELQCDAVVRKHVKTLSSKMLEKDLCRLVESYSQVDISHIAKMIGMDNEKVEKKLSQMILDKKLSGCLHQGEGVLVVFELPPPDHTYELGVKTIPAMSEVLDALYVRARNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQV5</accession>
    <name>A0A914YQV5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQV5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19757.t1">
        <property type="protein sequence ID" value="PSU_v2.g19757.t1"/>
        <property type="gene ID" value="PSU_v2.g19757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19757.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19314" checksum="BF1C2FFB6F5FA920" modified="2023-02-22" version="1">MSAAAPKNVLITGGCGFIGANFVNYIHSAWPNSNFVNIDKLILNSDVNYVSEEVRNSPRYEVCLADIRNRDVISRILESKTIDTIIHFAADCTSTRCYNEPCEAIENNVISYVQFLDTVKDYGKIQKFVHISTDEVYGDSGMESDEIPKSESELMYPGNPFWNSNYFITNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRY2</accession>
    <name>A0A914YRY2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRY2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20149.t1">
        <property type="protein sequence ID" value="PSU_v2.g20149.t1"/>
        <property type="gene ID" value="PSU_v2.g20149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20149.t1"/>
        </source>
    </evidence>
    <sequence length="532" mass="62578" checksum="8758DC5B242A5F3F" modified="2023-02-22" version="1">MDLNKSSHDQHHEVADKRNDQKSKLDEMAAKFDDKISILEKKYVENCEEILQNIAPNYMYSQNFDKFLTENLQFPSLDKICEMIKKRPREIFERIPGIEIQAAGFSHWLSLESKQPSFRRQKLDDKGFLECIDFAEPDLKNYTEEDEKDDEEMIKYLDLRYGSVFDNIADEIHDIKLAEEDEKKKKAQLKKGWNASKRFVAPGMEEEEIVQKVAPLIIRVDRMKIFRDIFDIDKRSLVSKILPPATQFVGNEPAMAKLFPLNETIYGTVVPDELPYHLELDHIINVLKRKKIYSLNEFQRLVVHLIQYPFMRKVPMMPLSNLLICAEQFHGFQTVLAPVLIKLVVEYKELNEYGEAPRELRFNRNPYILIVALNESDCLPLYQAFQPYLKGCQISVPPSGLTNVKLQQNLLHGCDIFLSDRRKLEFIRNGEIDLCNLRHVIFLDIDRFIDGNESLISDVHKYVQLALEKKRYDSGKKVSAKENFDVQYIFQTYKEFTNWNYFDQLLYRTQPVRDNLALILPYDYNAYNLNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS86</accession>
    <name>A0A914YS86_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS86"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3034.t1">
        <property type="protein sequence ID" value="PSU_v2.g3034.t1"/>
        <property type="gene ID" value="PSU_v2.g3034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037737161" evidence="2">
        <location>
            <begin position="33"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3034.t1"/>
        </source>
    </evidence>
    <sequence length="368" mass="39060" checksum="5ACA98A56DEA1E6D" modified="2023-02-22" version="1">MRINHLRKRFPKKYKVMRQFILLFLFIAFVTAADDALIETETGPKSSADLIKPDAAAIDKIPMGAAVGTTVVKDDAKAGAIAEEVLKAKTEDKSVKSSESKESKEESEGAKVVAVPKETVAIAHKKPGEEAEVAAATKADIKVVEPEPARVKRDKEAESVLEEGAVIDVGAIGTKEAVAQSKAIANKSKSSESSESKEDHKVEEKEEVETADTKKVLIAKAVPKETVVVAHKKAGEEAEVASVTKVGIKPVAVATVPVPAEATRVKREKEAESVLTEGAVIDVGAVGNKAAVAESKAIADKSKSSESNESKEDQKDKEVEAVKVSKVPTEKIAVAHKEAGDDEVEIATATKASIVAEKIQKSRARRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSV6</accession>
    <name>A0A914YSV6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSV6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3087.t1">
        <property type="protein sequence ID" value="PSU_v2.g3087.t1"/>
        <property type="gene ID" value="PSU_v2.g3087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3087.t1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36061" checksum="23D75FD615FD193A" modified="2023-02-22" version="1">MVIPLRVQNTTKGGKCDIIVFFVVDTGSPEITLSKETCAKLIGKGCRPLTILVQGKYFPFIRSKTSGEAFQNVNLLGTNFFLQSNTSLIFSPYKFIRPGIESSIFYLTSLKFIKKVQKLASTPNQNPNIFGKLGLESRTEEIRNFDHTLAHPPAALSVGMNDCVNLSRLEVLIYDFEIVSGTSSCQSCDIIVFFVVHTGASKVSFSKEAHGVLTKGGADPFNVLVQDESFTYILSENVRADLKDVNLLGTDFFFKTETSLIFSPYYHKFNRCKIRMFYITPFTLITGVKEIAERQQQNANFNEKLKVVCPTSLSQSDIRSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV46</accession>
    <name>A0A914YV46_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV46"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4018.t1">
        <property type="protein sequence ID" value="PSU_v2.g4018.t1"/>
        <property type="gene ID" value="PSU_v2.g4018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037617610" evidence="1">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4018.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15043" checksum="BCF617D653CB2C59" modified="2023-02-22" version="1">MMLRFFFFVVTFAVAKNACPSGFYEWHTDCYTFISNASGFADAENECIQKGGHLASIHDGFTNAWISQEASKYFVESTVSDFWIGLTDLINSGNWTWTDGTLMDFNKISFNSNLTSTNCISVSLINGQWHANDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVD4</accession>
    <name>A0A914YVD4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVD4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21470.t1">
        <property type="protein sequence ID" value="PSU_v2.g21470.t1"/>
        <property type="gene ID" value="PSU_v2.g21470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218205" evidence="1">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21470.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14348" checksum="8B863DA673071BA1" modified="2023-02-22" version="1">MIPWIFGYFLLYFFVAASPISENNSSSESPTQFLKATTIIAVFNATFSWKIENINLFDFGTNDHANTLLGPTLSAVDQKNDNKVYSIDFAISPEWIYNRQNYHELPKYELKKYDIISLWEKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWW7</accession>
    <name>A0A914YWW7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate-flavodoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWW7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2572.t1">
        <property type="protein sequence ID" value="PSU_v2.g2572.t1"/>
        <property type="gene ID" value="PSU_v2.g2572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050722">
        <property type="entry name" value="Pyruvate:ferred/Flavod_OxRd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154:SF0">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2572.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13094" checksum="92A9967F39F6E97F" modified="2023-02-22" version="1">MMSRLEHVEEEKINYDFFLNLPEIDRSKLERIDIRTSQLITPLFEYSGACSGCGETPYIKLLTQLYGDRMLIANATGCSSIYGGNLPSTPYTTDANGRGPAWANSLFEDNAEFGLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYT3</accession>
    <name>A0A914YYT3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="2">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YYT3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4796.t1">
        <property type="protein sequence ID" value="PSU_v2.g4796.t1"/>
        <property type="gene ID" value="PSU_v2.g4796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="3">
        <location>
            <begin position="9"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4796.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24326" checksum="9B6BED631954E6F9" modified="2023-02-22" version="1">MKNGSILDNFDAIQQCKVLVVGSGGLGCEILKGLALSGFKHIETIDMDTIDLSNLNRQFLFRESDIGQSKAEVAARFVNNRVNDVQVIAHNCKIQDKDLNFYRQFSIVICGLDSIVARRWLNATMKPFGDEPIDGDSPEHLTWIMERALERAKEFNITGVDFRLTQGVVKRIIPAVASTNAIIAGSCVLEALKLASNIGCPLDNYLTFSNINGAYFAKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZL4</accession>
    <name>A0A914YZL4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZL4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5067.t1">
        <property type="protein sequence ID" value="PSU_v2.g5067.t1"/>
        <property type="gene ID" value="PSU_v2.g5067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5067.t1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7175" checksum="D289806E3476EF27" modified="2023-02-22" version="1">MSATAEIGRVAAGAVSGDVKTSAGRRDAISSINSVTRLMALAAVSLQARLQANPAMASAVDTVTGLGASFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZP2</accession>
    <name>A0A914YZP2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZP2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3504.t1">
        <property type="protein sequence ID" value="PSU_v2.g3504.t1"/>
        <property type="gene ID" value="PSU_v2.g3504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3504.t1"/>
        </source>
    </evidence>
    <sequence length="92" mass="11128" checksum="2A2205AAFFCBEC01" modified="2023-02-22" version="1">MPVPFYLRYLVLCRKMSPEIVYSKKMFYAYFPVFIAFALTYIGLFWCYPPFAEHHLEFIEPLNTEFWLNEYGEIPLFAATKIVRFCITDEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z085</accession>
    <name>A0A914Z085_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g5587.t1">
        <property type="protein sequence ID" value="PSU_v2.g5587.t1"/>
        <property type="gene ID" value="PSU_v2.g5587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="909"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1508"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1587"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1508"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1592"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1603"/>
            <end position="1613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5587.t1"/>
        </source>
    </evidence>
    <sequence length="1613" mass="186109" checksum="D74A280910AF1A82" modified="2023-02-22" version="1">MNRKRQPGSSNQSTSDSLRARLNKTVYKSPSRTPLNSIQQPKASQSSNHQSGGQKQGFSFEDENDVPPDNSSINYNQNDTNQRNRREYFDTDVITEMNDAEAEANEEDPSLVSAARKFLRTQVLTRAPREDTEGRVADGYDRPIYKRFKKLGAAVHTNDNRDIYFYIGELTHVKLLKLIESKWDDDEFVKRIMIELKDELNTNQESWKLFLLQSKNVNGTQDTIFRALILSKHSQAAAFELLFDKLNIIATKKSNEEQLKLGQDIIYQLRYITQVFFPAVIFEKVFGKKIETWTPILRDNLIEMLPELFTDSSVHPNAAKNLLPFLKNWSLDSHKTLQVAWLNAIKCFDIVNTNIGNIIYEILMKNLMNFEVENLPLVIDTALAVSKKLETDVFKNFLFRLCKYLNIEEFKKMEEQNESIKNVDKHISEVFFRITEFMRFNVSRSEKELLNFYSINKIIRERSSKLMKEQKRNVKNDKDFDGSDADEEEDEEEEETDDDDDDDDEENPNDPDFVLEKNETSSDDNEREFELIDVMLLICFNEACNDSSFALKELRKQVSISYDYFVNLKERFREVLEWFPTFAQTYLRSIRVLARDLVQSPNPQINEFGVVIYKYLFYNPRVDRITVLKSILSHLSEVDSETTVALSTLNEIVEDKLEFLKEFMSEMNSLTDNLSFLSTENIRKLFYILISLNFSPETLRPTQAQLVQKKEGDKFINRLNHYLTSNIFREVIWGVIGLIQYVKVILLKDRNGDNNEKISTILNRVNEIVKNGRGKVRAEFYIQLSELLKPMKKLGECEALLHRMLNKMFITVSESNVNLNSISSVTDSTAENDKIRTCNVLYAAIEYIRTVLNMFADCLCEKEKVHSWMDKKLKLMIFCQSQLNRKIENLGIYTLPRITQINKDQLLVKGKKESKKKNPSKKKKDADVSMEIDKSRDATFVFDNSDETNESHSSNNASAHPFKAFELRKEEILKKISLDQLQWYCTPLRLETVTTLLQLNGQTRKHFVFLVETLHVILKHTMPIRGKQMPAGFSIGSVAPIPIATMDFGTKEHRWRHVSAVIPSLIELLSRSVTHFQSDRTQTDPNTDYSALLKFCVMIFSRIFQSREIAIECDHYDSDRTTNLLSRREAIVSSFNRIIYLLNSSNVPQGDVTHNPYISSSLMSQEDDEILDISNTAGYLHGRVSDNGRESLENNTNEANVIEFFIQTAKYVSTIECASAMLALLKTFDKMDEHQKRSCALTALHYLKKTWPDEDVPEALEERNALLIATDFIYFRPDEQKLTAINWLIWHQFLSLYPNSIVSGSGLVVGKYKDSEKFVNDFEGEIFPCFEKVPQWHKLLFKQFNDNIFLHLKVKGKIDPRMQNTQQFLKQWKIQIESFYVLVFVLNNPGFRVHNVLFTSIKEGKRFISFILSKQSSFSLFIRSKEVMANSYESIVEILKTLQSANELLYDLQAYVKDKKNLALLKLIPELKAAQEKMAREFYDASAQGGFNQTIKFDFSKAKHFAEEDKIEKKTKKPKGEKAAKKPKSDKPPGPKKSKAAANGGGKKRPTKSTDEPAKKRARKSKDTISILESNADASYLSIAHGLGGVDSTRNISGFVDSSQDDDESRMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z134</accession>
    <name>A0A914Z134_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z134"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6072.t1">
        <property type="protein sequence ID" value="PSU_v2.g6072.t1"/>
        <property type="gene ID" value="PSU_v2.g6072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040055">
        <property type="entry name" value="Ribosomal_uS10m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13334">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13334:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US10M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="36"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6072.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17216" checksum="EF37647A8FAD6B75" modified="2023-02-22" version="1">MLRIPRSLLQIRPLATQLTQSTSAQPKPDKLFKKIEFEVRGHDKAVLKSYMTFVQSACGHLDINYTEVENLPYVRWVEWLLRSKFVHKKYKLHYETRTYIKKCSVYYITGSTASTLVEYLQRQVPEGVGMKVTYNEICAFPETMSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z195</accession>
    <name>A0A914Z195_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z195"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5894.t1">
        <property type="protein sequence ID" value="PSU_v2.g5894.t1"/>
        <property type="gene ID" value="PSU_v2.g5894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098621">
        <property type="term" value="F:O-phosphoseryl-tRNA(Sec) selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001717">
        <property type="term" value="P:conversion of seryl-tRNAsec to selenocys-tRNAsec"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019872">
        <property type="entry name" value="Sec-tRNA_Se_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008829">
        <property type="entry name" value="SepSecS/SepCysS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944:SF2">
        <property type="entry name" value="O-PHOSPHOSERYL-TRNA(SEC) SELENIUM TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944">
        <property type="entry name" value="SOLUBLE LIVER ANTIGEN/LIVER PANCREAS ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05889">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0711">Selenium</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5894.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9583" checksum="A5952C8A539B942B" modified="2023-02-22" version="1">MGKKGLQKMMEERNQVYNLLVEKMKEFAAEIGEEIVEPEGNGISLAMSLSTLPIEECKKLGGILFSRYKVTGTRVIVSDEFWISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1G0</accession>
    <name>A0A914Z1G0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1G0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6549.t1">
        <property type="protein sequence ID" value="PSU_v2.g6549.t1"/>
        <property type="gene ID" value="PSU_v2.g6549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6549.t1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9650" checksum="9F9847BD68768A33" modified="2023-02-22" version="1">MFLVPVDFDKIDFRSFFDNKAVFEKVIESPSESEQKPAEELKDKDHSVIVPASVQKLETTPESSLRDPVIVKPPLKRKFKDIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2P0</accession>
    <name>A0A914Z2P0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29092"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Interacts with RAB5IF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z2P0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6617.t1">
        <property type="protein sequence ID" value="PSU_v2.g6617.t1"/>
        <property type="gene ID" value="PSU_v2.g6617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="17">
        <location>
            <begin position="375"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6617.t1"/>
        </source>
    </evidence>
    <sequence length="476" mass="52448" checksum="DACEA30402574B05" modified="2023-02-22" version="1">MASSIALLGGRLIQRNGLPTATRSFSAAAPTKTEEKKPEKTSFGNLKDEDRIFTNLYGRHDFRLKASMARGDWYKTKEIITKGSKWILNEISTSGLRGRGGAGFPSGMKWGFMNKPFDGRPKYLVVNADEGEPGTCKDREIMRHDPHKLIEGCLIAGVAMGARAAYIYIRGEFYNEAVILQEAIYEAYKAGYLGKDCMGTGYHFDIFVHRGAGAYICGEETALIESLEGKQGKPRLKPPFPADIGVFGCPTTVTNVETVAVAPTICRRGGSWFAQFGRERNRGTKLFCISGHVNNPCTVEEEMSVPLRDLIERHCGGVIGGWDNLLAIIPGGSSVPLMPKSICDDVLMDFDALVQAKSGLGTAAVIVMNKQADVVKCIARLSTFYKHESCGQCTPCREGCGWLDKAMWRFVEGKAKPNEIDMVWELTKQIEGHTICALGDAAAWPVQGLIRHFRPELERRMEEYSQKHGAVKQYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2R8</accession>
    <name>A0A914Z2R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2R8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6643.t1">
        <property type="protein sequence ID" value="PSU_v2.g6643.t1"/>
        <property type="gene ID" value="PSU_v2.g6643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6643.t1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16928" checksum="33C6D781D6A84FB0" modified="2023-02-22" version="1">MDLQNEKTFETCNKTLAEMDLLIGFSIGLNLFLSIGIIGLNCFLIYHFVWKQTVQTHIDAAGVSFSQAIRASEFARIPPIGIAVIAEMGGIPLDEVVSAYDKDSMERRAIVYSIMGRTAIAKKFVDQYRSIFMSKGYEGEETVLTTTTTGNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2W4</accession>
    <name>A0A914Z2W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2W4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6690.t1">
        <property type="protein sequence ID" value="PSU_v2.g6690.t1"/>
        <property type="gene ID" value="PSU_v2.g6690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6690.t1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30729" checksum="86A4DC8DBFCA4585" modified="2023-02-22" version="1">MHYIAKNPKNAKVYQKMIKRCKYFFVKNPILVLSHLSHSQNGWSTWVNETWKSIDINKISAKLWITGLLHVSPANVSNDSVVSSIISKIYQCDFKRLSLDNQVISLNEFIFLCLSAKYLTLERVTVKNNDGTVVAFENIIERLPQLIFFIFYSFTNPSNNTSKTSFKELWKNPHLSNYDRFYLKNIPENFEIDCFYTYMKKNKKTRVDLEFSDEVSEEYQIRLEAIIDEIIATKNHEYKPPLINFPGIDQEKYSKLFDISSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3B7</accession>
    <name>A0A914Z3B7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z3B7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4745.t1">
        <property type="protein sequence ID" value="PSU_v2.g4745.t1"/>
        <property type="gene ID" value="PSU_v2.g4745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF345">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="68"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4745.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18660" checksum="12269B06FC9F1EE1" modified="2023-02-22" version="1">MFLAIEGPNEEYEIRKQIEEREKLLEDTAYKLNTVKAMTPLQAYNHTVKTLDEYRENLGVKNPSLNNTQWTFWGSIYYSMTVYTTIGYGNIATQTTIGRVLTILYAFIGIPVALISLIALGGLFARLCMLLWSFMTRGSGVVSKDLEKKVIDNFYNKLFISYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3M6</accession>
    <name>A0A914Z3M6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z3M6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g696.t1">
        <property type="protein sequence ID" value="PSU_v2.g696.t1"/>
        <property type="gene ID" value="PSU_v2.g696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047170">
        <property type="entry name" value="PTN12/18/22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983:SF2">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983">
        <property type="entry name" value="TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="207"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g696.t1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34497" checksum="A5FC2A6521D9A7D5" modified="2023-02-22" version="1">MSDAESPEQRKAMENFVTEYEKTTTDKLNFQFLDIRKDQADLREDDAYSCSVGQSPQNFMRNRYRDILPYNANRVVLDPTSDNPDGYINASHITFPETSTQYIASQAPLPETVVDFWQMICQYKIKVVAMLCKCVESFAPKCEQYWPKEEGETKTYGSYTVTFVKEDAFNEYCHRSLLVKSEKYGELQVEQLHYTEWPDHGCPTGEEYILQLMERMNELHANDGSPILLHCSAGCGRTGTVIALNIIRELMNNKKLVLICVKQLVLDLRKQRTSMVQTQTQYHLLHKCIAVYCKKIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3R5</accession>
    <name>A0A914Z3R5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3R5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4895.t1">
        <property type="protein sequence ID" value="PSU_v2.g4895.t1"/>
        <property type="gene ID" value="PSU_v2.g4895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4895.t1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13199" checksum="5F436F04F3CB74C7" modified="2023-02-22" version="1">MEDGDLDVLREGTCDYLGFSYYMTNAVKAEGGTGDAISGFEGSVPNPYVKASDWGWQIDPVGLRYAVCELYERYQRPLFIVENGFGAYDKVEEDGSINDDYRIDYLRAHIEEMKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z447</accession>
    <name>A0A914Z447_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PH and SEC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z447"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5031.t1">
        <property type="protein sequence ID" value="PSU_v2.g5031.t1"/>
        <property type="gene ID" value="PSU_v2.g5031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13295">
        <property type="entry name" value="PH_EFA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF376">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="6">
        <location>
            <begin position="253"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="436"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="690"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5031.t1"/>
        </source>
    </evidence>
    <sequence length="760" mass="85920" checksum="A5C6A1A284174B88" modified="2023-02-22" version="1">MAEVISRIPTQVPVKTQKARSTEEAAATIPSRIPRFGEKLPQRHSHDGKSENVSSSSLEKHSDETLPVTSHPTTPRHEGEEKRTPRYEAFLMTGDKMLNLNPKVSPSYAKLRQEQLPPATEVGDSTPQRKGAFEEYPPLHQRGQRRFDLETAVPASQSESILDKHEDENDENSCMDSEACVSNLQNNIESNNVSSSTLPENASHNALYHIAQIDFNKTHSFITPQFLEGRIADYPRNSAGQKQQISNNIKPHLINQRENGIDAYKEIDNELVVNTAKQMFELNNFRRTTVAEFLIQSNPFGEALSQEYFQLFNFSGLRIDSALRDFLSHVCLTDEIHALTCALILLNTDLHGPNIGKKMTVREFVDNLGHTEHTYERNLLKVLYNAIKSTPFKYLDDEQEKVNTHVEPSTRASGVFRRLSRKVSKKATGAEIKDQIDYKHGWVYKKSVYDMDGKKTPFGRRKWQMFYATLRGMVLYLHKSEHGFESGRFNTYNNCILLHHAIASIPSDYKKRQNVFRLRTANFGELLFQTGDPVEVNKWVDAVNFVAAAFSSPALPPPTGSGTVVFNRPLLPSAPTTLSIQAQLRSHKEKVAEMEYRLSSLRKDAPSINTKGRQVYDYFFRERYLDNERERYVTYVKILREKLTSISQTDLCSRTSSVRRTPTKNVAAYITSIPITNNSTTLYHNAPTATQSTMSSARGNSLRHDGKLSTTSETSSTNQAPALAEAMRIASGCLPNVPAAGEIPIYSDEDRISYKEAMHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4C4</accession>
    <name>A0A914Z4C4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4C4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g674.t1">
        <property type="protein sequence ID" value="PSU_v2.g674.t1"/>
        <property type="gene ID" value="PSU_v2.g674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g674.t1"/>
        </source>
    </evidence>
    <sequence length="208" mass="22803" checksum="F4E1C45508A79CCB" modified="2023-02-22" version="1">MSRVRTSSHRETPSKCRRCLGHGIQIPVKGHAATCPFRLCDCSKCQKVVCRRISSSKNRLKNKCGVVFVKMRCLTGNVRVHAVCKDNLKCLKSSNVVSLVSPKQKENRFLSEPKHDTISPSTSASTSPQLVTKDPTVSAPFPTTLPASISPFCMPPMAPLSNPLFNLEALIHAYRLNLSLFSPQSCGFPLTATTPALMPVPIPTQRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5V4</accession>
    <name>A0A914Z5V4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z5V4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7288.t1">
        <property type="protein sequence ID" value="PSU_v2.g7288.t1"/>
        <property type="gene ID" value="PSU_v2.g7288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7288.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="12087" checksum="053FBB73BFFF8A8D" modified="2023-02-22" version="1">MEYRNDEESNEGRDFRGNSGCFNPGDERVCDKRGPGPDGNFEQREREDGDGQFRDGRDDREGRFEDANESDGFERREFDDHRDDSNRDNDEEERHRHRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z676</accession>
    <name>A0A914Z676_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z676"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7831.t1">
        <property type="protein sequence ID" value="PSU_v2.g7831.t1"/>
        <property type="gene ID" value="PSU_v2.g7831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7831.t1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31007" checksum="9849AB4B01BAFC5E" modified="2023-02-22" version="1">MVLIVVDSCSKWIDAYPMKHANARATTECLLRYCADNGTPRLIVSDNGTQFTSVLFKTFCLENGIKHTTSPVYHPQSNGQAEKMVNVYKRFIKKKALQDVNGFDITVATSQFLLSYRTTPNTATPGRCTPAKAHLGRELRTILDQIRPQIAAEFNENVKQNESFDRHHGAKRRFFEVNTAVFYRLKKDADWYPAIVIKSIGSRLYRLSNTENGKEIRVHANQMKRRNVELPSDHSLRFLRSPDDYDYDNVGSEITQSTRSRTPSSTLSSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6I4</accession>
    <name>A0A914Z6I4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6I4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8295.t1">
        <property type="protein sequence ID" value="PSU_v2.g8295.t1"/>
        <property type="gene ID" value="PSU_v2.g8295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000800">
        <property type="entry name" value="PRK00055.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8295.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24057" checksum="EC789F3ED19DE750" modified="2023-02-22" version="1">MSGIIQPLTIYGPQGIREFVETALRISGSWTDYPLEIVEIGAGEILDDGLRKVTAYPLEHPLECYGYRIEEHDKPGALNAQALKAAGVPPGPLFQELKAGKTITLEDGRQINGADYLAAPVPGKALAIFGDTGPCDAALDLAKGVDVMVHEATLDITMEAKANSRGHSSTRQAATLAREAGVGKLIITHVSSRYDDKGCQHLLRECRSIFPATELANDFTVFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7C6</accession>
    <name>A0A914Z7C6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7C6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8227.t1">
        <property type="protein sequence ID" value="PSU_v2.g8227.t1"/>
        <property type="gene ID" value="PSU_v2.g8227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8227.t1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10323" checksum="A51CFDFC3BF0FCFB" modified="2023-02-22" version="1">MTEVSEACIEHSKNPLNLEMDDENVKTRQVRIHWGKNEVYQIEENEDDENWSDFEDIADDLADESGDFTKKLNAARMSYPQVSYFAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8B1</accession>
    <name>A0A914Z8B1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8B1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8914.t1">
        <property type="protein sequence ID" value="PSU_v2.g8914.t1"/>
        <property type="gene ID" value="PSU_v2.g8914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8914.t1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24916" checksum="FEE0204B65880110" modified="2023-02-22" version="1">MLNKNLEDLSVGTLEEDLINQGGTPQNNNIITIDDDENVDDAQLDEVANNALQIPLSAYNLNKVINKEYIDDVTIDSVINKDVVQRNPDILLVSATVWQQRIIENWGDERRLPNRLPTIPRYSTTFRKAVIPIHMQNHWNVAVLDKETKKCVFYCTLRWELGEPYYSKLKLICCLLCDGEECEIVTAPDDSFLMQYDGYNCGPMICMLAYRILNNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8R8</accession>
    <name>A0A914Z8R8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8R8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9071.t1">
        <property type="protein sequence ID" value="PSU_v2.g9071.t1"/>
        <property type="gene ID" value="PSU_v2.g9071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9071.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18414" checksum="57036EFF126AB910" modified="2023-02-22" version="1">MTSKKRHYIGTVFHFIDDEWKMRTFPIDIHEFKDRSTAENICNDCEIFLAQLNLNIGDLFIVTDEGANVIAAFKNDNHIRCICHELHTWCKRSLDPYKAANIPITLDDDVKIDINFINDVMKKMKIVVNAVRSRLLLKNELSLSLIVDCDTRWMTKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z956</accession>
    <name>A0A914Z956_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z956"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9206.t1">
        <property type="protein sequence ID" value="PSU_v2.g9206.t1"/>
        <property type="gene ID" value="PSU_v2.g9206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9206.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24579" checksum="48649F110C2F097C" modified="2023-02-22" version="1">MGTSTTSYDESESQVIKLLSNDSSASGDQLFNETMTAVIVVTEEVDKLTHFLTKYTGTKTWNSERIIVAAIAIPAVVVFGVQLCTFATLLGSFGYNLWRSQKNAALAEQARITADERFKTLLAENKKLITEVKKVVEVSHDSGTRIVEKLDEKVKDPMNILMAAYDTYTETLVSQALMDLNQTCATHKPKDLIVVRKLLVTRQATNICSVTYGFLVNGKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9R3</accession>
    <name>A0A914Z9R3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z9R3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9408.t1">
        <property type="protein sequence ID" value="PSU_v2.g9408.t1"/>
        <property type="gene ID" value="PSU_v2.g9408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="27"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9408.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20116" checksum="6C6711FC07D7E390" modified="2023-02-22" version="1">MAYPCGIEASKWLTSLHPTFPQSSQILRLLSESCENSTAIDDKKMATLQNSTFTNEADYLLITWASVNAIAEAVNLSAKEVAKRFRPNFIIETFTNIPFEEDQFLKIDIAGIPFKVTSKCTRCQMISIDQESGEKDPKVLLALRDARCGDKITFGVYLKRLTNQEIEISEGSTVIIERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9Y3</accession>
    <name>A0A914Z9Y3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z9Y3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9479.t1">
        <property type="protein sequence ID" value="PSU_v2.g9479.t1"/>
        <property type="gene ID" value="PSU_v2.g9479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F13G3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9479.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21261" checksum="4BD0C8535AD8E2D4" modified="2023-02-22" version="1">MQEIVEILEVYQKKNFIKIEQFAFVDFDAATISNIGINPMLELNSRNQPLALTDCLMKYREASEFIIVADVDDVLFPERKPFYNEFTFWSKIYSNSSAFMYFRSYAKIEVAETFKKFSFEKTIKSLRKVDILDIGKTVYKTAKAEVAWIHWPGLKNASTATIPPNKGRMLHVQIKKSALYMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAW7</accession>
    <name>A0A914ZAW7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZAW7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9805.t1">
        <property type="protein sequence ID" value="PSU_v2.g9805.t1"/>
        <property type="gene ID" value="PSU_v2.g9805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9805.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34862" checksum="5EA6ED9E29AC55E5" modified="2023-02-22" version="1">MSINYSEALSPYPNKGKLGQKEIVDKELDLNQKIIELTDDIRNAKFIVVLTGAGISTSAGIPDFRGPNGVWTMEQKKQEPKSVDFATAKPTFTHYALVALEKVGKLKHLISQNVDNLHVKSGFPVNRLLEVHGNCFVDQCKRCKKYYYRNDSSNSVGCKPTGKRCTGAKCRGFIHDTVLDWESELPDGYASITIPYLKKADLFIVLGSSLQIQPVGSLPSEAKKTRKTKVVYVNLQKINRKTFDLTIHAPVDAVFRKFMENLQISVEEKIHDEPVLFSNFSIQQDDVINTDHIPLKNLKKKSMKHVLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBS2</accession>
    <name>A0A914ZBS2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9374.t1">
        <property type="protein sequence ID" value="PSU_v2.g9374.t1"/>
        <property type="gene ID" value="PSU_v2.g9374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9374.t1"/>
        </source>
    </evidence>
    <sequence length="481" mass="55022" checksum="BE8C129DA149BAD1" modified="2023-02-22" version="1">MFGIGKSRKRQWKAAFEKSQCSLCKEIFNDAHKTPCNHIFCKECILMAIRELSKCPQCKKVLNSTTKLIPDEDTQKIADADRIDYEIEDFVKSRGYEELSHNIDNVLTHFLRNKPNIDAGEARKILFQRQHKLIKQQNDRKYTLVLEFLDALKTNRIAEATKFLYESNEAQKDYRNYLQKIVNIHEDIRPPHLNGILGPPPQMGDFSALRIPEITAEDILKPRDQLMIKHFENELQNIRMPQYSSSNYLDEFGDIAAGICKYTSMSTIATMDYSRDGHGQSNTTNTPAVVSAIEFDKDGEYFVIAGIAHKMKLYDFDSVMDKPQAATPIAILPTTIKVSNVCWNPFSKPILATSYYNGSVQVWDCHASRILHTYTEHEKRCWSIQFNSVNENLMASGSDDQKVKIWSLLQGNSIQTIDTKVLVCCVHFNPATETQLAFGGSDHCIYLYDMRNLQKPVKILRGHKKAVSYVKYIDSNHIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZC41</accession>
    <name>A0A914ZC41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZC41"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7814.t1">
        <property type="protein sequence ID" value="PSU_v2.g7814.t1"/>
        <property type="gene ID" value="PSU_v2.g7814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7814.t1"/>
        </source>
    </evidence>
    <sequence length="97" mass="11723" checksum="714D2A7F3744479D" modified="2023-02-22" version="1">MELNDAILEVIWSLLIRGLRTYCRVNRFNFSFCICPVAKLKARHRGDLECVLECKQWYVNQRDWLWAAAQFPNTIPVTTCRRCGHRYFQDDYLGYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCZ0</accession>
    <name>A0A914ZCZ0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="12"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZCZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9813.t1">
        <property type="protein sequence ID" value="PSU_v2.g9813.t1"/>
        <property type="gene ID" value="PSU_v2.g9813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.100:FF:000006">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000109">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="13">
        <location>
            <begin position="42"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9813.t1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41738" checksum="190257CBB1D6A034" modified="2023-02-22" version="1">MTAATSTFSKLPPLPALRDFIHMYRLKAKKILSQNYLMDMNLTRKIARKANFDSNTHVIEVGPGPGGITRAILDEGCARLDVVEIDHRFIPPLEHLAEAADGRLHIHRGDVLKTDLATIFKDAKIVQQKEWFDFSPNSHIIGNLPFNIASPLIIKFLREMSREEGPWQFGRTPLTLTFQLEVAQRLCGEIDSEHRSRLSIVTQYICEPKILFVIPGVCFVPKPEIDVGVVKFIPRAEPLIPCDFAVVEKVARQTFTFRQKYVSKCIKTLYPTEIADEMAHDLLKNCRIDPTQRPFKLGIDEIGAMCVFYEKQCQKMPGLFLHEVFKKNQTIEMLANEPNALPPTFKKLKGGISYSSFEDGIPLSKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDF4</accession>
    <name>A0A914ZDF4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZDF4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9975.t1">
        <property type="protein sequence ID" value="PSU_v2.g9975.t1"/>
        <property type="gene ID" value="PSU_v2.g9975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9975.t1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25766" checksum="996B142ACEE68AE2" modified="2023-02-22" version="1">MTTLFMNDMSQAERIDYRKCEEDILENKFEDKLIPYIEMCILNAEPLLKILRLISLQSQICNGLKLVTLQAYRKSIVQGYGIEILSWFLRLEMAGLIRCSDKSEKMSTYLPVDFINLKKRFKLFSTEPPQLGDIARYYNGYVPLLIRILEEGEQADFTNWDFIEPAKNVPIKKKLLKDRLLFVVGGVTRAEMGIIKERFPDMKYCCTTATITGNQLIEGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRA9</accession>
    <name>A0A914XRA9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XRA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10530.t1">
        <property type="protein sequence ID" value="PSU_v2.g10530.t1"/>
        <property type="gene ID" value="PSU_v2.g10530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10530.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17913" checksum="A8E9F07FF5AE9CAB" modified="2023-02-22" version="1">MSPESIQHRGDDDKVHIPLASDIWSLGCILYLMVYGTPPFGHITSQMAKINAILYKDIEYKPIEDEQLLNCMQLCLQRNYQNRPTVSQLLEHPYLRPSSSSTSTTKDSAISSLNSSMNESTEEDSIIVGKIFEEVSNNTPRTASKNVYKMLKAHTICTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XRM6</accession>
    <name>A0A914XRM6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XRM6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10648.t1">
        <property type="protein sequence ID" value="PSU_v2.g10648.t1"/>
        <property type="gene ID" value="PSU_v2.g10648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0868">Chloride</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="50"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10648.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25114" checksum="8E4872543E3A4C50" modified="2023-02-22" version="1">MIAVLIANAVSSYLQPSIYDSIIQIKHLPYLPDIPHSSSNFHGICVEQFMTSNVKYLSKTSTFAELENLLSKMPKLKAFPIVEDNKNPVLIGSCNRAKLLQALDKHVGHAARQSEANRRIKEAIADIDRRFKIVDRQRNSISTDALTTDRPTIFINFKTDEENNETPPKIVIAASTPTDNLKTFDSANHRTQSTSAPIPAAIEAQSSTTSRFTVLPVNECKSSIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSA9</accession>
    <name>A0A914XSA9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polysaccharide biosynthesis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XSA9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1016.t1">
        <property type="protein sequence ID" value="PSU_v2.g1016.t1"/>
        <property type="gene ID" value="PSU_v2.g1016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="1">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1016.t1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56716" checksum="637DBA59E29BF778" modified="2023-02-22" version="1">MADLATQLHDDPEKYINDPNVEFAWAMKAAERAGVHMNILLSVDTNKLKLTKDQTEVYDKFRELFPKLNVEKVSDQELKGDNKAIWAEFCECFNFIEDYNLGTIMRIDASGVYNSENTLIVPKIIFLAIEGARNIEGINEKFKSQYLEEYKKTQDGSGQLMLIFSGCKRQYQNQLRSSCFYLHLINGVILAPVDHDCPPRDTDIVLQYQKFLEEGNGPLARRMTSLVNFDFGETSLANIVNKLNLPSSSLQRSSTLTGKGNENINVEKTLANLKRKLIVTDYTSSSADKPCTAKKSKEIEVGDKIHISINHKNTVKMMEKETTPIRITTFLFEKPSVSALKNICNKLDIKYCKEAMNFWKEIKFIHIDTVSTNIQTQKFKTKNFYKILSNFFTGKFCDYDQIYYAINMAFGEKLLADDQLSYEEIDLLCSSFTVTEKHFKFIAKFIPCRILIFDSDSDKKEPRKFGKWKNDCRNILTLVLSFSNRKYSVVLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XSR3</accession>
    <name>A0A914XSR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XSR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11012.t1">
        <property type="protein sequence ID" value="PSU_v2.g11012.t1"/>
        <property type="gene ID" value="PSU_v2.g11012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11012.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23033" checksum="71B15D3E5DA4B0F8" modified="2023-02-22" version="1">MAFIQTLLPFVVLVAINIIIVKRLSAVHTIEKQHMQKLQQAQALPPTPKSSASLNPFHELRRASMKKLSFSRIRMPASVRNAVYTTMAIVASYLICNTLHLALTVLERSKASILEDKEDSLKASTFYTFFGDSVSALYMVTSAIRILIYCKCNPVVKQQVVETLENIFSHPKCHHDDVTKVKPTQCFITIENDKFSSQYPSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTS2</accession>
    <name>A0A914XTS2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914XTS2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1136.t1">
        <property type="protein sequence ID" value="PSU_v2.g1136.t1"/>
        <property type="gene ID" value="PSU_v2.g1136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1136.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8117" checksum="A017F6713A31B326" modified="2023-02-22" version="1">MADRAGYAAVVSHRSGETEDTTIADIAVATTATQIKTGSLCRSDRVAKYNQLLRIEEALGAGARYAGRDAFVSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTV8</accession>
    <name>A0A914XTV8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTV8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11392.t1">
        <property type="protein sequence ID" value="PSU_v2.g11392.t1"/>
        <property type="gene ID" value="PSU_v2.g11392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11392.t1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25192" checksum="769AD849CF859EE3" modified="2023-02-22" version="1">MVDEFDFDAPKSATFFEEKENEPFVLNKNASSASRISNLNSSKSRQNCNGLYSSRVNSNLCTNHNQNDEYAKPPTITSSSTESSSRQLSSTLQSNRSPELFHPDISEIQNASLKPEKNISTTLNGSSSSTLFYHSNLYKDLNLDESSKAMALKYLNSPRTNEKKADISERSSKLLDSLKARSNNNAAVKPQPEKPHQFSLNSLVDHFSSFTRPTTPTSKKSSRNCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVA8</accession>
    <name>A0A914XVA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactokinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XVA8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11873.t1">
        <property type="protein sequence ID" value="PSU_v2.g11873.t1"/>
        <property type="gene ID" value="PSU_v2.g11873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="4">
        <location>
            <begin position="119"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11873.t1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36290" checksum="BC79B107B9EF5057" modified="2023-02-22" version="1">MPSIDNIEEELCSKFEQKFRHKPQILVRCPGRVNLIGEHIDYSGFSVLPMAIKHATYVLLRKNGTEKINFFNTDEKYESYVHDATIPWTGTTKPKWYHYFLSGWKGSQEQLRSPPNESLGLDVLLSGNVPPNAGLSSSSSVVCAALLACLAANAKLNPEKLDRSGLADVATRVERYIGVEGGGMDQAIECLASEGQALRIDFNPLLSTQVHLPKEALFAVIHSGAEYNKAASSYYNERVVECRIAAQIVAKRLVHCNWREIRTLRHLSEFLQKDFEDMIDVINRHFDEEPMSRENVLRELETTDDDLIEYSLNNNTTQKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVN6</accession>
    <name>A0A914XVN6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914XVN6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1200.t1">
        <property type="protein sequence ID" value="PSU_v2.g1200.t1"/>
        <property type="gene ID" value="PSU_v2.g1200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF57">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="244"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1200.t1"/>
        </source>
    </evidence>
    <sequence length="498" mass="56838" checksum="1A7FA1F2CDB5A5BB" modified="2023-02-22" version="1">MNFVRSISTTSKAIEYPHTNWYHDQGMLRLTLPKRITETASDLRFEFDYSSFLKIYIYQPRKKKEEFDPVFNVNDIINFMDRAEDEYSTFQLTITIGIGYPPEIFIYRGNGNLHKRVHTELPGEANWKNLVQSSNIQVKLSFDSEQGCRNFISHLHSAVSCPIIFLSNPLEIQPSDIPLIPPNISSLPWENPNMVDGKIDDALAFLAAIHANLKLQPMMEVIEIPRPITVNFGDDFVLMRTVIITPTRKICCPPMQLMSSRAFRILGGAEKFIQVKFRDENMAMMKRDNEMMAEVVLSPGLDGINIAGKMFFDLARSNSMFREHGSYFYQTENQNEIVKILKSLGNFKPEPSSKTSARVGQYFTSAREVKHKLESHEYTVIPDYISDATNSKDEPYCFSDGVGIISMKFANSIKEEFNLAYLPSAFQIRCLGFKGVLSIDHRHPMLIDSGGDKLVLFRESQKKFDVPNSMEVVLGIVKHSAPASVRFNKPLINLWDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XWK8</accession>
    <name>A0A914XWK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XWK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10152.t1">
        <property type="protein sequence ID" value="PSU_v2.g10152.t1"/>
        <property type="gene ID" value="PSU_v2.g10152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10152.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17712" checksum="899B842939A015BB" modified="2023-02-22" version="1">MIINEVLSYFNKNNAKENEQEDEDENLQDGDDLTQKFYLNFRIPFEKEHAENYAASEFSNEKVLSLLTENSTNMSLEQLKLLEEFRVCCICREYTKDILAAKVLHKIREIQDQRGRNLQELEKQFQERMVKLNSQFEKAKFELMDKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX41</accession>
    <name>A0A914XX41_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XX41"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11778.t1">
        <property type="protein sequence ID" value="PSU_v2.g11778.t1"/>
        <property type="gene ID" value="PSU_v2.g11778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF63">
        <property type="entry name" value="DNA HELICASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11778.t1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55516" checksum="824A99F6993B75AF" modified="2023-02-22" version="1">MFRLVFGRDLPPLGADMMADGYDRDGAPYMRTLQGERVKSLEECVIADWLFYNGVAYDYERRYEFDTATDTHRQYRPDFYYPDAQLYHEHFALDADGQPPKHFANYSEGMHWKRQQHAARGTALVETTSFGLRSGQALQHLAERLGASGVELDPNPDRELPDQGAKPMPDADLIGLMRTFIAHAKSNCLTLDDMAARLRQMPEDQFKERYRRFLEIAGPVFQAWDNALADERSIDFEDMLNMAAGLLEQGHYESPYELVMADEFQDASRARTRLCRALVSQPGRHLFAVGDDWQSINRFAGADVSVMTGFREWMGHGQVLKLEQTFRCPQALCDVSSRFISRNPAQIAKAVRSAAPTMGPVLQAFQMNRREEVQDGVRQYLAKLHQQLLSGAVPQGRNGRVTVFVLGRYRADRGAVPSDWKTAFGSTMDVEFLTAHRSKGREADYVILPGMINRSFPSLRADDPVLSLAMPDGDTYPLSEERRLQALAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX70</accession>
    <name>A0A914XX70_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XX70"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12543.t1">
        <property type="protein sequence ID" value="PSU_v2.g12543.t1"/>
        <property type="gene ID" value="PSU_v2.g12543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12543.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17861" checksum="A460AC5073635A89" modified="2023-02-22" version="1">MSLSDSSECSELSYDEVYSLDDLLQMKIIGNKVANWIKQNPLPEDDPLLLLEYRDPNVANRGNEIRLALIANGATEITPTVFQFATNDSVFEAQHNMMNTHTWAFYNSSPMLMVHRINQPGQVVPLPQAETISTKLVHSYSASKFNVDKKFCFFRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXC8</accession>
    <name>A0A914XXC8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXC8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11616.t1">
        <property type="protein sequence ID" value="PSU_v2.g11616.t1"/>
        <property type="gene ID" value="PSU_v2.g11616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF6">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11616.t1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33963" checksum="4389CE7424478B22" modified="2023-02-22" version="1">MAEENGTAGLEQDIKNDLNQKQSANGNASGGGGGGKKRGKDDVCRDFLNGICNRGNRCRFRHPETEDHSAPNHSSITPYTFCIDFQNKGCFRESCRFIHASGQDAEHYQQKGIVSLPLARAIAATLTINDSINGIPICKEFQTGACSRGGNRCRYWHVNVDEERAARTNMLRMGGNAPGVPMGMPSYTPGMRRGAPMPLDYEYDHIPVKRAFPGRMPLPHPPSSYGMEPPSAYVTSLERRNAELEKENEALRREVDREKSRYEDLMAVFKGQQQQHAAPAPVPPPMQHPQYPGWGHHESHHPSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y177</accession>
    <name>A0A914Y177_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chalcone-flavonone isomerase family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y177"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13206.t1">
        <property type="protein sequence ID" value="PSU_v2.g13206.t1"/>
        <property type="gene ID" value="PSU_v2.g13206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13206.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15770" checksum="4F5147BC86FE8251" modified="2023-02-22" version="1">MFIYFPSFTIEVDIGLAADVGSLNRLPKICGNNSWIREISFTARSFDAKEALENDLLSKVYPTQEIMKVEVEKLAKIIASKSPVAVEGTKIILNYSRDHSVQDSLTFTANWNMSQLFTEDVPKSAMASFQKKELPQFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1X2</accession>
    <name>A0A914Y1X2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1X2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13457.t1">
        <property type="protein sequence ID" value="PSU_v2.g13457.t1"/>
        <property type="gene ID" value="PSU_v2.g13457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="1">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13457.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21804" checksum="B49A96D0EA56C700" modified="2023-02-22" version="1">MEKSIWKMAPWFIMASFFENEEYKAASERKDKNEWAKVLQKITETLSPYMDCIVWFDGDKWRACIDTSFSKDLENIQVLTNFQDQHEFGILWDKISYCMKIHVEENQLEIISAFYTHKKQKNVYAKNHGTVVCHIAAAHIPLKPHKDGIAPGAQIISISVSTSVESLKKAVIYKFLFEFIYQFYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2G3</accession>
    <name>A0A914Y2G3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UBA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2G3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11986.t1">
        <property type="protein sequence ID" value="PSU_v2.g11986.t1"/>
        <property type="gene ID" value="PSU_v2.g11986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11986.t1"/>
        </source>
    </evidence>
    <sequence length="459" mass="50501" checksum="721D2E55D707C354" modified="2023-02-22" version="1">MLVTFTIDNENFSTLDVSQDLEVENFLALVAMENPSVSTSDSTFVMIVNGRQWKIDGDVLKMKLYEIGVENNDMIAILKVQPRQAPGSSRSSMGGAAASQAGSSSGGGRGNLSDLIRSIQVPTKSSKPQQRPQGQGMQAYADTMVKRINPEQQHQISRNLFIQMSSPLAQLRFKDEYPSAVASYLKEPTNYEAFHGAMINDQKDFYRRLALTADPTSIEGQKMIADLIKREAHKEQLQKAMTEMPEAFIRSHMLYVKLKINGVETIGFVDSGAQVTTISAAHAEKFNLSSKIDKSFATILRGVGGEQYSEGRIHSADIEVSGHVFPAPLNVLQRFGEDILIGLDTLRRHGACIDLGKNVLRLGTQGIEVPFLNERQYVDECKRLGVHANVAPDDKEPLPESEVSNEKVAELVNLGFDAHSAVKALAISQNDIVYACDLLQSDDPAPKEKDDTSEPMDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2J9</accession>
    <name>A0A914Y2J9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">F-ATPase delta subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y2J9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12014.t1">
        <property type="protein sequence ID" value="PSU_v2.g12014.t1"/>
        <property type="gene ID" value="PSU_v2.g12014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12014.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="17520" checksum="440C70C0D23BBCC6" modified="2023-02-22" version="1">MFSAVRSFRAVARIIPKRSYASPAAAANTGGTEELRLTFSSPASAVYANTTVKQVDVPTLAGTIGILANHVPVIGVLKPGVVQVTESDGTVNKHFVSSGTVAMNIDGSCQVLAEEILKIEDIDESLARQELDTANRQAAEGGSEVDRAEAQIRAEVADALVKAATGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3B3</accession>
    <name>A0A914Y3B3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3B3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13265.t1">
        <property type="protein sequence ID" value="PSU_v2.g13265.t1"/>
        <property type="gene ID" value="PSU_v2.g13265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13265.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="34979" checksum="FBDAEECD7EE95C1B" modified="2023-02-22" version="1">MYFLGLQIKRNHPASTSHNQPESDDDDSDIEVAVVSRKPKRRSDANNAKLIPKKKKSLSSNVHDDDESVNIDELSDEASAHDNSDDKPVRSLPQKETTLSHPKKDKEELYERRLSLPNEDIILNAHDDFEFVKPKKYGKPQLYIFIPDNKEFCYKFTRVQDGSSRYRCLGCFAKSRKINVRTDEDKQLYVTLSKYRSGEYFVRMGTKIHCCEPIKYESQKYQGKEMYDCYEYFYYRKIERPASLNLAIPHPENKEFCYKFFYLPSKSHYQCIDCDRQKKKLTMVRRTDCEEDDIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3P3</accession>
    <name>A0A914Y3P3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3P3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13393.t1">
        <property type="protein sequence ID" value="PSU_v2.g13393.t1"/>
        <property type="gene ID" value="PSU_v2.g13393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13393.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14194" checksum="B7FA589FF6DC2716" modified="2023-02-22" version="1">MTRARRAEPGDVHADGGLGPRGGGAGSPGCGRCRPAAGPPAADQAAADGGEWNRHHRRWPPRSAAARCQRPAEHRIDAVPGGIGDPAVQFTVGQTVNFEPTGADQGWELKDNQGRPLEYLPEATGPRDIFDTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3S6</accession>
    <name>A0A914Y3S6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GOLD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3S6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13427.t1">
        <property type="protein sequence ID" value="PSU_v2.g13427.t1"/>
        <property type="gene ID" value="PSU_v2.g13427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036972980" evidence="9">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="28"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13427.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23378" checksum="CC17CA91BC2BE612" modified="2023-02-22" version="1">MIMLKVLFSLTLICSTSAFSFHLDARDRKCFSEDVRADTIVMGKYKVPVYKPNSFETHPAVTIFIEVRDSNKKVVMSDQYTNEGKFIFQARTSGEHEICTTSNASVWINIDAGKPVEKDSEKVQETNDLQLRIFELRDLLNQVVAENNYQHNRKERMRQTIDSTNTRVFIWAITEFLLIIAMAAWQIHYLKRFFEIQRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3U0</accession>
    <name>A0A914Y3U0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3U0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14860.t1">
        <property type="protein sequence ID" value="PSU_v2.g14860.t1"/>
        <property type="gene ID" value="PSU_v2.g14860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14860.t1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32407" checksum="CF664CDD59DB207F" modified="2023-02-22" version="1">MFNIELPKQFDDVHRQTFYIPSTIFSYIFLIAKFKIKLKLYQTCKQLGLKFVYASETFEINGFSKTVVEIEDAIIPLQKFCSTYYGLQAKSVKYQNMDIGSVDVLRNNNIDPEYVETLKISSSVVLFMFDGICKFLTPNLKKIDIQQVLFADIDAALELAKPLPWILNKSPNLESITFGVINFSQAFDTLKSVYTSNKLLEANFIVYNQVVDPEVITYFIFFQMAPKSVLKLLFHFDTGAKEFLQELNEYMDSQRNINQVQVFTFIQINILLYFKSFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y504</accession>
    <name>A0A914Y504_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y504"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14314.t1">
        <property type="protein sequence ID" value="PSU_v2.g14314.t1"/>
        <property type="gene ID" value="PSU_v2.g14314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14314.t1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24854" checksum="56B3764536674A12" modified="2023-02-22" version="1">MDYTFQVGVISLQDGTVYWPKELKIRTDPSGPPFVDTPEFLESRHPGTAQIKIKCASEEYGPISHYWIIVVPGNFTKDDVLNIDSQNLEKSTLAMKPKISLAAPIAKKVKKAVSDEDDNDDDDDDEEEFLTEKVKRALEEEMLEASEYVADESLINDSGISSNDEEAPSPKKTTLRNKRYLHESKRKLDGIYIAAKIESQEMRQLVKEDKTFIQIIDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5H9</accession>
    <name>A0A914Y5H9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5H9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14025.t1">
        <property type="protein sequence ID" value="PSU_v2.g14025.t1"/>
        <property type="gene ID" value="PSU_v2.g14025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14025.t1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25595" checksum="F67690B000D84E8A" modified="2023-02-22" version="1">MLKNLTAASDSVEGFIETSQEYTFKKLAQRIVYKRAKLVSLSTKDLITVLFVDYGEVVDVPVADIYMYKFSKKVPEFLTVLVSEDKLAKTLQLNDLYIFDFIKEKYIYVGRPTSNFDIAPNPLNDLSTSTESVYFGPGSNDWENEESKNDDEILFVPAAEENKTKKDDELVVYGLEDGWTFEDDANEDSDDSSFVEFESIRNTALENDEDDDYYADQGSVGSRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5L9</accession>
    <name>A0A914Y5L9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5L9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14732.t1">
        <property type="protein sequence ID" value="PSU_v2.g14732.t1"/>
        <property type="gene ID" value="PSU_v2.g14732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF315">
        <property type="entry name" value="CUTICLE COLLAGEN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14732.t1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22855" checksum="3DDA2D74F674AFF8" modified="2023-02-22" version="1">MAKMKEEEKNKNDENFKDSEYLRKITLFGIALSTTTVIASIIIVPILYSYIQYIQTSLQNDVEFCHHKTAKLWDEYISLQTSSNSLPLRLKRHAYVPVGSPQFQYIQPLPQFYQIKRQSFQRQPPQPIYQQQSGRTSDIRSSTSSSQVCSCGMGPAGPPGEPGIDGEPGADGRPGNDGMNGPDAAPGQLPKASDFCFNCPPGPPGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6H4</accession>
    <name>A0A914Y6H4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6H4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15794.t1">
        <property type="protein sequence ID" value="PSU_v2.g15794.t1"/>
        <property type="gene ID" value="PSU_v2.g15794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15794.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22886" checksum="11276C1841635075" modified="2023-02-22" version="1">MFGCVPFPTQQRALLSSLLEQLLIYYDISKATNMKQSNSINSYFEFGSFSLITFLHASHFTRLISAPLDSPELSFYGRSHRTFSYLFNTLFNVEQLSDGIGYDLSLFDPEIPLTPIKAYLKHLEKLGFEESKLYPVKIEPRPFVKLPGDIEVPFKLQKFQRDENNEDEIQRRKQVINFAYWILMAGKNPKQLKQTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6W2</accession>
    <name>A0A914Y6W2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6W2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13376.t1">
        <property type="protein sequence ID" value="PSU_v2.g13376.t1"/>
        <property type="gene ID" value="PSU_v2.g13376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13376.t1"/>
        </source>
    </evidence>
    <sequence length="85" mass="8762" checksum="0EA6132A02C8C3D1" modified="2023-02-22" version="1">MLNHDISTTSTSESSTTAGDKLIAENVDATTIIIEKIQPSEATTIETATISIVENAQSVAPIAPLGAGQVVVGGSTTSETKIRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7X1</accession>
    <name>A0A914Y7X1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7X1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14849.t1">
        <property type="protein sequence ID" value="PSU_v2.g14849.t1"/>
        <property type="gene ID" value="PSU_v2.g14849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="130"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="236"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14849.t1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40056" checksum="4E99DA1105D039C3" modified="2023-02-22" version="1">MSDPSPTSEISQDAADNTTPKEDPPAAVEEKQQQPPPQVIPVAVIPIRGSAMPVLPQHGKVYIGPGAKKEAQVLGLGLSSLHRSERSDLDRAKRFAMEQSIKFTMQKQQTAHQENQQKVAMYAQALSLMARVYVGSISFEIREDQLRETFGEFGPIKSVNMSFDASTGHHKGYAFLEYEIPEAALLAQEAMNGLMMGGRNIKVERGRVQLQLGRPQTMPQAQPIIDMIMTEARKYHRIYVASVHEDLNESDLRTVFSSFGNIIKCQLAKSTSGKHRGFGYIEFDTPRAAAEAITGMNMFDLGGKLMRVGKCLTPPEALSYIVPNTQTQLPTAAAMAAAAITARIQAQEAAGVSNPSVLPRTFSGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7Z8</accession>
    <name>A0A914Y7Z8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y7Z8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16322.t1">
        <property type="protein sequence ID" value="PSU_v2.g16322.t1"/>
        <property type="gene ID" value="PSU_v2.g16322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16322.t1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10734" checksum="0211D354A514DB3B" modified="2023-02-22" version="1">MNIPNLDKVKKHYEEQMKKYQSVEKEREKVIINRQQLEAQLTENNLVKTELDLLESGTNIFKLVGPTLIKQDLDESKNTVNKRLEYIGEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAB2</accession>
    <name>A0A914YAB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YAB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15704.t1">
        <property type="protein sequence ID" value="PSU_v2.g15704.t1"/>
        <property type="gene ID" value="PSU_v2.g15704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15704.t1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39391" checksum="D1C11EF028D6219A" modified="2023-02-22" version="1">MVVFKSPFKPVQIAHEPFGDFVLAKLWQHAVEHPEKKAIVSAEDENIFVTYADLYIQSLSVASFLHQRHFGHGDIACLVLPNCYQWAPIFLGCSLQGGAASGASVVFTDYELERQFIDSKSKIIFCAESSLDRVLKAAKNCPLINTIVVVEHDPKHPSKEYPFGIHKFSDVIKCPPMRGVPAKDIDVNRDILLLPYSSGTTGSPKGVMISHKNFGTMLNIVFAHLHDYVGEVFKGTYVMHKETDILLLPFYHIYGFGVLMNTLCSGKTAVLLTHFDPDVFFRSIEKFKVRMLMLVPPILVALAKHPIAQKYNLSSLEMCLSGAAPAGKDLIDEVQRKHPSIKVIVQGYGMVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAQ2</accession>
    <name>A0A914YAQ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAQ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17283.t1">
        <property type="protein sequence ID" value="PSU_v2.g17283.t1"/>
        <property type="gene ID" value="PSU_v2.g17283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17283.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11704" checksum="EB148AE3DB88BEC9" modified="2023-02-22" version="1">MEPKTACLNFLLIFGGLSVVSVSLKVIQMHIESVFVGIVQSIEDDFKDTLASERRKSIGTDKQRSSLTNGGGTDGGETTILLTMPEGERRDLSMNNNSGSSGKSINIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAV2</accession>
    <name>A0A914YAV2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAV2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14619.t1">
        <property type="protein sequence ID" value="PSU_v2.g14619.t1"/>
        <property type="gene ID" value="PSU_v2.g14619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="1">
        <location>
            <begin position="26"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14619.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28270" checksum="85DDF56C888D0A89" modified="2023-02-22" version="1">MSLKNYIPKDVTQQSEFLKKYPEYDGRGIKIGIIDSDIVDKSLPGMQKTTDGLPKIIECFGKYLITIDTSKIVERNGKNYIIGLNAEKLYIPIKWKNPSDKWHLGSKSVFEIKMDGKKSGIFIDDFDKTDSKRKLAAMKNKTLNCIVWFDGKQWRACIYNTSLYNFQNLEKIEVLTHFEDEQEGALNSKSKLSCKISDDGNTLQFFGLYDDHATLVSHVLAANFPDNPESNGLAPGAQIVSIQACILEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBA4</accession>
    <name>A0A914YBA4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidyltransferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBA4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14763.t1">
        <property type="protein sequence ID" value="PSU_v2.g14763.t1"/>
        <property type="gene ID" value="PSU_v2.g14763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14763.t1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21315" checksum="40098CEF6A086C19" modified="2023-02-22" version="1">MGLSIPPYIVHIEMFIMGKECMEKHGFKVVKGVMNPSSDSYKKSGMLSLFHRNEMCKLSVSNDKHNWIIVDNFEDSNPVTILQRCHDKMIKEYGEVKVMYLCGADAIDSFIEAHSKGKSKFWTFEELKTILDKYGMIIEVNSNRPGNASDPIKILKALNLPTKNVFAVFSTDDISRNYGRKCYKLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBA7</accession>
    <name>A0A914YBA7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBA7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16565.t1">
        <property type="protein sequence ID" value="PSU_v2.g16565.t1"/>
        <property type="gene ID" value="PSU_v2.g16565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036949414" evidence="1">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16565.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22037" checksum="C654C03BF8BFA2F0" modified="2023-02-22" version="1">MAQIFGFFVFFGLIALCNGCQSGIDNVARDMQKRHPQKCMQCPEIKFSEQCNYESMDKDLTCGKSYMDIYTYWSNKQMCAKITVHCSAQPPKTIDARIAVEELKPTQTIPELSKTISDSQNFTDSDLSFIEDGSGTEILIDESNDGPTYSYISKEEKFHAFSYLTCNDDGKWETVDPNGKKFVGIEIVHCIVVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC12</accession>
    <name>A0A914YC12_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YC12"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15015.t1">
        <property type="protein sequence ID" value="PSU_v2.g15015.t1"/>
        <property type="gene ID" value="PSU_v2.g15015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15015.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15396" checksum="A579DF384829E3FF" modified="2023-02-22" version="1">MALNFPRLAVGAAVRRTGQVQATRNSSGSFYGSNNFDHFRKEYVGGLKPAEGTKETWKKIFWIASLPCLALTFWAAWADHSKHHAAPRREYVEYPYLNVRNKPFPWGDGNHSLFHNEAEQYVPGVGFEKERHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCJ5</accession>
    <name>A0A914YCJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCJ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16472.t1">
        <property type="protein sequence ID" value="PSU_v2.g16472.t1"/>
        <property type="gene ID" value="PSU_v2.g16472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16472.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8238" checksum="7AADD46E4C0F11B8" modified="2023-02-22" version="1">MPFEDIPQLVLYHKNQGPLADLIREMISFSALAFTEISVTSPNPHLPEILPAFSMDNDVTCGTHAVCRRISAIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCS3</accession>
    <name>A0A914YCS3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17230.t1">
        <property type="protein sequence ID" value="PSU_v2.g17230.t1"/>
        <property type="gene ID" value="PSU_v2.g17230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17230.t1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17865" checksum="B1D03C7479AA1A5D" modified="2023-02-22" version="1">MLHYIAKNPKNTKVYQKMVESCKYFFIKNPILIISKLRYIHNGWETRVNETWKSIDMNKILCKLWITFELRVVPENVNNTSVASAVVPKIYQCNFKRLLLCDQVISLKEHMILCSSVKELRLERVIVKNEDCTLVTLEKLIEQLPKIKRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD64</accession>
    <name>A0A914YD64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-hydroxyacyl-CoA dehydrogenase NAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YD64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17382.t1">
        <property type="protein sequence ID" value="PSU_v2.g17382.t1"/>
        <property type="gene ID" value="PSU_v2.g17382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF1">
        <property type="entry name" value="HYDROXY-ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17382.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22408" checksum="8B0AE25530E8ADAE" modified="2023-02-22" version="1">MVVEIQNEIQNVVIFGSGLMGSGIAQIAIENGFSVTLIGRSMDKLHQSKTKLSNGLTRIAKKRFVNDAEAQNDFVDACLDNLKLCTNSDEANLEDADLIIEAIVENLKVKQKLLAEIENVISETCIVATNTSSFLLQDIASKYSHKSRFAGLHFFNPVPAMKLVEVIKGQETSDEVYETLLEFCRKVGKSPVRCRDTHGFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDX9</accession>
    <name>A0A914YDX9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YDX9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15631.t1">
        <property type="protein sequence ID" value="PSU_v2.g15631.t1"/>
        <property type="gene ID" value="PSU_v2.g15631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15631.t1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50685" checksum="7A9394648432A737" modified="2023-02-22" version="1">MLKTWKYFGVRHFSNRPLPITKDEFQARRASLVHVAKPEFPSTYGVSVAAIVKGASRTSYAPDVYYPFRQSSYFRYLCGINVADSFLYVTEKQSVLFIKEVDDHTALWDGNRYTPKDLQKISGVDQVLGVKEFEGFVAKEIRDKHVLIELDDFKDSPLMELFVKRPNSKLIPVVDKIRWRKSDAELELMRETCRIGSAAMNTMIKKGKMVPNEAHLSGRLEFEYRKRGAIGSAYPPVIAAGSRARTIHYLDADQDISPGDCVLVDAGSDFEGYVSDITRCFPISGKFNDPQKVLYEALEAVHNDCLNFVENIRPLKLNELYFHMLRSMSKHFTKAHLFKNGMSKEETYSICDELCPHHVSHYLGMDVHDTFSISRSIDIHSNVIITVEPGIYCREGIKNIRKEFHGIGFRIEDDVLVTKDGSEVLTSTCVRESDEIEKHMNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEH3</accession>
    <name>A0A914YEH3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEH3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17852.t1">
        <property type="protein sequence ID" value="PSU_v2.g17852.t1"/>
        <property type="gene ID" value="PSU_v2.g17852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17852.t1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29581" checksum="6A3E561CBB3B9EA7" modified="2023-02-22" version="1">MCDQNILQIVDQNDMEEEYDETFQNNILKRVNITLYYKDGPSSDVTLDSATISVNDSFGNKLLNDTPLGGYEYTLGAGWSPWTNAGNAGNDWLAFSEYAHNNIGAQISVCVDLRIKANWFQPFNYLPSLESASSKLETICEKVLKDIYTKKLIVPDSEFFDQKIDKFAYHRHVFKFACLEILERLDKSLKSQISLSKIQTVFAHIYFNHVIMAETVCFEDFVEILEASITTNFPELLRECERFICREVMVVSFFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEY1</accession>
    <name>A0A914YEY1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YEY1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1731.t1">
        <property type="protein sequence ID" value="PSU_v2.g1731.t1"/>
        <property type="gene ID" value="PSU_v2.g1731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10492">
        <property type="entry name" value="MH1_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF62">
        <property type="entry name" value="SMAD PROTEIN DAF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="10">
        <location>
            <begin position="565"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1731.t1"/>
        </source>
    </evidence>
    <sequence length="807" mass="90373" checksum="2AB37C3BA1A0279B" modified="2023-02-22" version="1">MEVDANPENVANIIRRQTPPPSSGDSVGTIATFLSKSVQGDDLEFGRKAVESLIKKLKDKRDELEDFITAVTTKGETHTGCITIPRTLDGRLQVAGRKGFPHVVYARTFRWPDLHKNEIRHLPFCLYGFELKTDAVCVNPYHYERISLTNDGGGGDMNNMLGNVLIPGGSGSGNRTTTTATDHIRTSRLFKNEEHPNHHHHHHSISGAAAARRSTMPSIQKPEPIPSTSQQPITSSSLLQTSILSSLLQNTTTTNTSNPPTFAQAFLANQLRQQILQQQQQQQQQQQPNPLAFLLNAVNEQKRQNDEMMEDTVEHFSSLQTNPTAVPLPQPPPPPSFLSLSNIIIPTTTGMVEAAQTCPQSTATSIMPQTVSSTTITSRLIDNMPQITRRQRASTFPVQSLLQFLAAEYPTLELVNLQQINIPKLFTDNPNLLRLTQRLSAVQALQTELLSRGQSIEEYRSHQREEMIAALGAFITAINHQEKTGHPGTDNFTPEHVLLATIIAALANGAASGALTLEQPPVPISVCPEGLDSENTTLVDFISTSLYYSKCFHGETNKLYCGEYWGTVSYFERDFKYEGLFECRKDTLYVCTTNPNDHDVDCFNISQFFGLRHIGDEGIIYDRNKIDIGVRIDVRNDTELWVTCFSPLPLHIESSYLDRESGRDSIIHKAYQQSTIKIFDLRQVIHQILYSNAYRRVVGGKLDGYEREKINIQVLNDMQNLTKIRMGLGMRNKDVNNTLLRNAPCWVEITFPKLCELVNELSIQPFIHFPPHLRQLSIFGGTPEGILPQEYVNEAIELILSEGLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF52</accession>
    <name>A0A914YF52_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF52"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17388.t1">
        <property type="protein sequence ID" value="PSU_v2.g17388.t1"/>
        <property type="gene ID" value="PSU_v2.g17388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17388.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17650" checksum="1446132C06EFADE4" modified="2023-02-22" version="1">MLSRTLGKQLFSTTHLFRSPNIGGNFKPILANRTMASEVDKAQTATSGEDTIFGKIIRKEIPAKIIFEDEHILAFHDVSPQAPIHFLVIPKRRIDMLENATDEDEAILGKLLLGARKAAKELGLSDGYRVVINNGKDGCQSVHHIHLHILGGRQLGWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF64</accession>
    <name>A0A914YF64_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF64"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16018.t1">
        <property type="protein sequence ID" value="PSU_v2.g16018.t1"/>
        <property type="gene ID" value="PSU_v2.g16018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16018.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20692" checksum="C25CB7FECD403476" modified="2023-02-22" version="1">MVEFIVPRSFLFYHVDLIRMLFGAHDIKQEILFETVYKLAENEATKKQALSLDADFNFDDTIKREMIRVLSKFKFDEMNLKFVVEFVVVKRFLFSVQQLYDLLIKCQRNANQEEIFFKAVYMLAEKSVMEKQEVNLAENFDMKSAVKEEMMKYLYHFKFSLMSLEFLTDFVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFN6</accession>
    <name>A0A914YFN6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL18c</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFN6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18126.t1">
        <property type="protein sequence ID" value="PSU_v2.g18126.t1"/>
        <property type="gene ID" value="PSU_v2.g18126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000001">
        <property type="entry name" value="50S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_uL18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_uL18_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18126.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12645" checksum="8FA49848278EF682" modified="2023-02-22" version="1">MNKNIARLRRAKSTRAHIRELGVARLSVLRTGQHLYAQVFTADGSKVLAAANTTQTDVKEGLKNGKNADAAAKVGRIVAERAKAAGVEKVAFDRSGYRYHGRIKALAEAAREAGLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFT5</accession>
    <name>A0A914YFT5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor AP-2 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFT5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17622.t1">
        <property type="protein sequence ID" value="PSU_v2.g17622.t1"/>
        <property type="gene ID" value="PSU_v2.g17622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="208"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17622.t1"/>
        </source>
    </evidence>
    <sequence length="392" mass="42936" checksum="CA50DFA7F8A20F7B" modified="2023-02-22" version="1">MENILEEVGKTTQSSCCSSEDDEIEGEESGIDIKNSNAIEYPPENGQQSRLFDYGHHQHQQHQQQQHSLELSTLTPQNSGVGYPVHSYFSYPFSGAPDFSDGYQNHGPPTFFGTPAISYGIPYPPGIGQIPGVNENNLSSNSNSLSQSHLHTEFSGNSSSGASSPISQCEDFGGAASKATPQLLADTSFNNSTASNLAFVQRSPFETFCTVPGRTSLLSSTTKYKVTVGEIQRRISPPECLNASLLGGILRKAKSKDGGKALRESLKRIGLALPAGRRKSANVTAWTALVEEEAVHMAKDFHSSCERDFPAKEIGIFLCRNVATEDDAHRRRTMLHYVRIFIKEISDLMNSDRSPICGNRPEIILDPSIQKPLTHFSMVTHGFGGLLFLYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG24</accession>
    <name>A0A914YG24_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS14c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">28S ribosomal protein S14, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YG24"/>
    <dbReference type="SMR" id="A0A914YG24"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19250.t1">
        <property type="protein sequence ID" value="PSU_v2.g19250.t1"/>
        <property type="gene ID" value="PSU_v2.g19250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_uS14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_uS14_bac/plastid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006477">
        <property type="entry name" value="PRK08881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19250.t1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11424" checksum="59CD0670C5F0FD49" modified="2023-02-22" version="1">MAKTSMVNRDIKREKLAKKYAEKRAALKKIVSSVDATYEEKIDAATKLAKLPRDSSPSRQRNRCELSGRPRGVYSKFGLGRNKLREATMRGDVPGLRKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGT6</accession>
    <name>A0A914YGT6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YGT6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18005.t1">
        <property type="protein sequence ID" value="PSU_v2.g18005.t1"/>
        <property type="gene ID" value="PSU_v2.g18005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18005.t1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17413" checksum="DC2CB49C1CD64ECD" modified="2023-02-22" version="1">MQNAENHFPRTQSNQDDDDDDLAFIRSRSPLAYNDDDDDDDYPVGDIIPQTSSNSNERIYHDGNYYEPTHTSNDYDIYEIQEVRQPFYDSTTNKEEYYWKDPNPRVHEDDDEDDETPRDRILPPFTGETTNKTTYLPHIPIKDEKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHQ4</accession>
    <name>A0A914YHQ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHQ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16837.t1">
        <property type="protein sequence ID" value="PSU_v2.g16837.t1"/>
        <property type="gene ID" value="PSU_v2.g16837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019422">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10318">
        <property type="entry name" value="7TM_GPCR_Srh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16837.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19654" checksum="D2215509C3EE70A2" modified="2023-02-22" version="1">MCGLSILYSIIYQYISLIKSPEIFKNPKIFAAMYLSMIVYPIPMLSLYVINVDFEAGKAYVIENYPYLSTIYVPKSCNTILVNYTMYAYMISGIIEISTIYIIGITLFIKIHKQLVDMRHSLSATTLKARKQYVRALIIQATVPLVFIVIPITGIMFSVVIGMAKAEGKFDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHX2</accession>
    <name>A0A914YHX2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHX2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16913.t1">
        <property type="protein sequence ID" value="PSU_v2.g16913.t1"/>
        <property type="gene ID" value="PSU_v2.g16913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16913.t1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11668" checksum="2A5FD712FE782816" modified="2023-02-22" version="1">MNTVADYKTKPFNDILKIPAKVMINEACIDFLVTSECTVEGAIRTLYDSNLPCLFVVDNEGEKVIGVISYADIMDFLLKLHENPKIMKTANGIRSRINSIAQANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YK80</accession>
    <name>A0A914YK80_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YK80"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19741.t1">
        <property type="protein sequence ID" value="PSU_v2.g19741.t1"/>
        <property type="gene ID" value="PSU_v2.g19741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19741.t1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16617" checksum="18FEB371B43428C1" modified="2023-02-22" version="1">MYDTWHVIKGIASIFRLEMKNKRGKVLQEWCQSFLNHLWFSVTSAKGDGDLCQEYAVSTLLHSTGVHEWVEGKMSDVLHDSQVAVQGVDDDAVLKYDPSYLPGKLIHEIEFKNHLKCSHQADNIGDKGVLSTTSPSYWVLLKSFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKJ5</accession>
    <name>A0A914YKJ5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TonB-dependent receptor-like beta-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YKJ5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g194.t1">
        <property type="protein sequence ID" value="PSU_v2.g194.t1"/>
        <property type="gene ID" value="PSU_v2.g194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="entry name" value="TonB-dependent receptor, beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="Beta-barrel_TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="Beta-barrel_TonB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47234">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47234:SF1">
        <property type="entry name" value="TONB-DEPENDENT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec_b-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB-dependent receptor-like beta-barrel" evidence="4">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g194.t1"/>
        </source>
    </evidence>
    <sequence length="457" mass="50661" checksum="F43E4C23634C3B19" modified="2023-02-22" version="1">MNLQRVFAPEDIGGGGYRDIMNTDRNKAYQVTLGGRGTAGNWDYSLSFTRGEYKLTERNFVRWNDPINDYFEQRVLGPVLGTTSTGYDIYSPNWEAFYAPLPAGDFQSFTGYSYSESRTWQNLARAQVTNGSLFKLPGGDAGFAVVVEGGSEGWDYTPDPGLMDGSVWGTTAVSGAGHRSNYAVTTELRMPLLETLTVTGSGRYDAFKIGSNTVDKATYSVGIEFRPIESLLFRGKYGTAFRAPTLSDAFQGRSGYYANGSTDYYRCGQLGYDPANTTGCPYDSVSIKNEVDTLSSDQLLLAEYYCRNGQSNNTSASCQNVSDWITRDASGVLDEIYTPKMNVARQNLEALTASFKYVQDIGRFGSLQFSANYTDMLKRKLQPQPGDEYLDLLHDPYAMWVYDSYAKVRADGSIGWAKDNWTTTLYANYIGKTPNYMAYVGNGYDYVHSSGYKAGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL82</accession>
    <name>A0A914YL82_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YL82"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20111.t1">
        <property type="protein sequence ID" value="PSU_v2.g20111.t1"/>
        <property type="gene ID" value="PSU_v2.g20111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000002">
        <property type="entry name" value="Serine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42811">
        <property type="entry name" value="SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20111.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15106" checksum="D673F326853DF109" modified="2023-02-22" version="1">MPCRPIASVTGCGIRGVDIHPAAKIGRGIMLDHATGIVVGETAVIENDVSILQSVTLGGTGKSGGDRHPKIREGVMIGAGAKILGNIEVGRGAKIGAGSVVLQPVPPHTTAAGVPARIVGKPDSDKPSMDMDQHFNGINHTFEYGDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLZ0</accession>
    <name>A0A914YLZ0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLZ0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21346.t1">
        <property type="protein sequence ID" value="PSU_v2.g21346.t1"/>
        <property type="gene ID" value="PSU_v2.g21346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21346.t1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20227" checksum="6CE74CD201900D7C" modified="2023-02-22" version="1">MKDEMKDVKDRRLNILVIDRKVKAEVTLPVYNSTSDFDFNFGDHEVRAKLILDSKTIRKVFHEVDPKENPSVNFYFQHDLCQITTNAETLKCVTTFRKDTAEVFDVYSDRDGLTFDYKSAFIKRLRYATNNSIQVSLSMNDVGILSAQFRFVKIDRNHAHVEFFANPMEIAIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN01</accession>
    <name>A0A914YN01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YN01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20970.t1">
        <property type="protein sequence ID" value="PSU_v2.g20970.t1"/>
        <property type="gene ID" value="PSU_v2.g20970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20970.t1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24039" checksum="79D1C546D2D5DC91" modified="2023-02-22" version="1">MEQEDPDNSVAFDIFEKSTRLVDERFEVGVRWKLTKKPLHSNLGLAHGRLSSVYKKLKERQKGLEEYDGKFKVQVEQEIIEAVEGESEDGEIVQFLPLLPIPKPKKPATKLRIVFGGYEKPCKDNPSINENLPCQKIHDGSGRKNEKFSSKQNDAKILSKWKVIDGEACYDPDIVPVFKAKLAFMKAYYGIVAAETVVAINVKEAIVPCWKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNF1</accession>
    <name>A0A914YNF1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YNF1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20493.t1">
        <property type="protein sequence ID" value="PSU_v2.g20493.t1"/>
        <property type="gene ID" value="PSU_v2.g20493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020338">
        <property type="entry name" value="SMN_gemin7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14679">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14679:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11095">
        <property type="entry name" value="Gemin7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20493.t1"/>
        </source>
    </evidence>
    <sequence length="87" mass="9854" checksum="941DA2DD8B5BFCEA" modified="2023-02-22" version="1">MSDEQNARAELKKRYGDFVSVFDEQDVIVQLYQKNTMLVKFLAMQGNSEHFIVENLKTPTGVMDKAVLRSCDTMFITLPFAAESSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNP7</accession>
    <name>A0A914YNP7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YNP7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2123.t1">
        <property type="protein sequence ID" value="PSU_v2.g2123.t1"/>
        <property type="gene ID" value="PSU_v2.g2123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="12">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="10">
        <location>
            <begin position="226"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2123.t1"/>
        </source>
    </evidence>
    <sequence length="454" mass="49152" checksum="1A6BBC932947B042" modified="2023-02-22" version="1">MPPAARDHVKEAEYGFVYGVSGPVVTAEKMSGAAMYELVRVGHSELVGEIIRLEGDYATIQVYEDTSAVTIGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDISDMTDSIYIPKGINVQALGRDIKWEFIPSKDVQVNSHVTGGDIFGQVNESVLVKHRILLPPNACGTVTYIAPTGSYTITEKILELEFSGEKKSYSMLQVWPVRQPRPVNEKLAANYPLLCGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDAIIYVGCGERGNEMSEVLRDFPELTMEVDGVTTSIMKRTALVANTSNMPVAAREASIYTGITLAEYFRDMGLNVAMMADSTSRWAEALREISGRLGEMPADSGYPAYLAARLASFYERAGKVKCLGNPEREGSVTIVGAVSPPGGDFADPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYRSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNR6</accession>
    <name>A0A914YNR6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-terminal methionine N(alpha)-acetyltransferase NatE</fullName>
            <ecNumber evidence="3">2.3.1.258</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50564"/>
            <dbReference type="Rhea" id="RHEA-COMP:12726"/>
            <dbReference type="Rhea" id="RHEA-COMP:12727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133398"/>
            <dbReference type="ChEBI" id="CHEBI:133399"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50580"/>
            <dbReference type="Rhea" id="RHEA-COMP:12734"/>
            <dbReference type="Rhea" id="RHEA-COMP:12735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133406"/>
            <dbReference type="ChEBI" id="CHEBI:133407"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50568"/>
            <dbReference type="Rhea" id="RHEA-COMP:12728"/>
            <dbReference type="Rhea" id="RHEA-COMP:12729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133400"/>
            <dbReference type="ChEBI" id="CHEBI:133401"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50576"/>
            <dbReference type="Rhea" id="RHEA-COMP:12732"/>
            <dbReference type="Rhea" id="RHEA-COMP:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133404"/>
            <dbReference type="ChEBI" id="CHEBI:133405"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50572"/>
            <dbReference type="Rhea" id="RHEA-COMP:12730"/>
            <dbReference type="Rhea" id="RHEA-COMP:12731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133402"/>
            <dbReference type="ChEBI" id="CHEBI:133403"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.258" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YNR6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2498.t1">
        <property type="protein sequence ID" value="PSU_v2.g2498.t1"/>
        <property type="gene ID" value="PSU_v2.g2498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="30"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2498.t1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21437" checksum="C98496B8B043969F" modified="2023-02-22" version="1">MGNRSCHSTDINNNNNNTTNNYIISQNDDEILRHLTCRDAVKAKELSVISFPVYYPMHYFVDSFNNKKLYFSVGILSKFEQDLLGFMIALPNYTEDEFRMQFYSEPEKALINRFNSKIAYIASIAVHPKSMRRGYGTILINALIDACMKWESKPGAIFLHVKSDNEKAIKFYEKTGFIQDSFIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNT0</accession>
    <name>A0A914YNT0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear Hormone Receptor family</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNT0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1901.t1">
        <property type="protein sequence ID" value="PSU_v2.g1901.t1"/>
        <property type="gene ID" value="PSU_v2.g1901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46397:SF5">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46397">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="164"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1901.t1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49652" checksum="F64AA9AD56C1B985" modified="2023-02-22" version="1">MQEVKSPMLKVCCICSSPSSASPHFGAISCLACAAFFRRTVSLSIEFQCSENNSCKVYYEQRIICKACRYQRCIMAGMKSECVQKRKNIKKSSKEENSSPRSISPREVPILTNFPLVPKHAVSPSTSSFSNNSFPNSATTDCSSTPIFSPIVPTYNNFKPIITNQMEIFENLRSIDILEHFVEEERRSMERRRIMFSSSPLEALLGCSSPFSVSDLIPFTVKSHNTHMRFDHLLSFEYTKNLPGFHHLSIEDRICIFKYVIMGFCALDIAYLTSQMNMVEQGYLVFTNATYSSALNFDVGWDDEDEISAEEKAKLIWPMNQKFYEQLLKPMAKINLDQVEYSALKALTLWRTCYFELSPSAKLFAKELEYGIIKGLHNYYQNREDGPERMGDVILFISNIFDVYLTIIENYKKLELFNLIKIDIFVKELLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP61</accession>
    <name>A0A914YP61_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Aurora kinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YP61"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2631.t1">
        <property type="protein sequence ID" value="PSU_v2.g2631.t1"/>
        <property type="gene ID" value="PSU_v2.g2631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="222"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="10">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2631.t1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42611" checksum="1046E7D553805EAB" modified="2023-02-22" version="1">MIAAEEVTANPILRTDKTAKLKDASRVNESVNIADSDISAYHSVNNAESDLTIVLDEFSSFTMLPTDVPAVESDEEKSNESLMETKDQTMDEKDAIGSSIIHPVEMIDHDEENYNESLKENVKLQNATVTSVDDSIVEESVLFKPRTVEEKIATTKLFHKVLNDINKTVVGNVSDMETDSINETSDNQNTERNVAETSNVHPRVDHLPSSAPQYKVWKLSDFDIGKPLGKGKFGSVYLAREKESLIVVALKILFKSQLINAHVELQLVREIEIQCHLNHPNILKLYNYFVDDKKVYLILEYCLNGELYKVLQNQKDSRFSEKQSAIYIFQVADALNHCHSKDVIHRDIKPENILIGADGELKLADFGWSIHMSSSESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQ01</accession>
    <name>A0A914YQ01_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCD97-like C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQ01"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2899.t1">
        <property type="protein sequence ID" value="PSU_v2.g2899.t1"/>
        <property type="gene ID" value="PSU_v2.g2899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2899.t1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16553" checksum="8407E37388E55A8A" modified="2023-02-22" version="1">MRERDPLLFEVMVGRFLEDSERISLRPTVDRPEGTWSHMLQQFEDAGHISRRRKRQLENEWAMPCSSKETARFMSHAGARIASLDNLESIEGLDDKDEEVLRSTYPKHCAKNDIDSIMKKFRKTNVQQAEDEEGLVLCRCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQJ4</accession>
    <name>A0A914YQJ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YQJ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19624.t1">
        <property type="protein sequence ID" value="PSU_v2.g19624.t1"/>
        <property type="gene ID" value="PSU_v2.g19624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19624.t1"/>
        </source>
    </evidence>
    <sequence length="76" mass="7915" checksum="116FA1231861B46F" modified="2023-02-22" version="1">MGIVDQLSEISKTSSPFSSPIRSAACASKSAGEPVPFGSGKYYALCGFGGMLSCGLTHTAIVPLDLIKCRIQVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQK6</accession>
    <name>A0A914YQK6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQK6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3088.t1">
        <property type="protein sequence ID" value="PSU_v2.g3088.t1"/>
        <property type="gene ID" value="PSU_v2.g3088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3088.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11236" checksum="1F8B914D00809F43" modified="2023-02-22" version="1">MPSDQNDVYDGTDNSYLNDPPSSKRLTIAHHHYTDSDGDNSVCVPPEFSGPEVVKKLSGDKSSGLTPVSEAIMKPIRNLRSRGQSSEGRARNYKTVAVEQEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YR11</accession>
    <name>A0A914YR11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YR11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19811.t1">
        <property type="protein sequence ID" value="PSU_v2.g19811.t1"/>
        <property type="gene ID" value="PSU_v2.g19811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19811.t1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29438" checksum="83644FAE632E2335" modified="2023-02-22" version="1">MLLEIGEGRFGDNPNEIEIPPECVSKGDIIDEIFGDVMENYDPATVMKRAILATWNKDVDELNEQVLELFDEQTEKIYHAQDIYHYGDEILQNAGEIHENYKVRHIKGLPSFKLRLRKNAIVMLVRNLSIEEGLCNGTRLVVTNLLKHNLVVKKINIDGTLSDEILIPRITLTTKHGVVEVTRHQFPVKLAFCMTINKSQGQSMERVGVVLNHECFSHGQLYVAFSRARSMEGLKVVLPEEKTKTANIVYKELIALGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS33</accession>
    <name>A0A914YS33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YS33"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3548.t1">
        <property type="protein sequence ID" value="PSU_v2.g3548.t1"/>
        <property type="gene ID" value="PSU_v2.g3548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF222">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3548.t1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19963" checksum="3B6FF5BF3B104011" modified="2023-02-22" version="1">MGLCHRLELSNADVIFLRTQTNSGVTNGLQIIADSDKEDQTKLLFDSDKDNENITSFLNLIDYLRVNSKMDVRGLFSQIFEAGFRYFVHADTEFPSLSTEGITVSPGTRVYSGISPIRYLLLPEEHWGNCTEEWPKNLQNVNMTYSSAKCKSLCKAKYFYDLCGCSPFIFNVKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSI6</accession>
    <name>A0A914YSI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2037.t1">
        <property type="protein sequence ID" value="PSU_v2.g2037.t1"/>
        <property type="gene ID" value="PSU_v2.g2037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2037.t1"/>
        </source>
    </evidence>
    <sequence length="248" mass="26105" checksum="5E5D6C86C6C198D1" modified="2023-02-22" version="1">MQKDSIFAVQDVVEADKDFVDHKIVAMSDDLLMTKMNSQTLKEYVVTYLKILQQEIVNCCIRVEDLAESLNVVADVDVVVVGDKLDYLVKLAAITSEVDFHIAVVDVAVVVVDVVVAVVDIGVVDGVAVAVDVVVAVDVDVADGVAVVVAAAVAVVVVDVAAAVVVVGVAVEVVVAAAAVVVVVAAAVVVGAGVVVVVVDAVDVVVVVVVQLLERENAENFVVVEMQHHFDYGYDDIVVRHVEQDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTK4</accession>
    <name>A0A914YTK4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GTP-binding protein LepA C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YTK4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g401.t1">
        <property type="protein sequence ID" value="PSU_v2.g401.t1"/>
        <property type="gene ID" value="PSU_v2.g401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF4">
        <property type="entry name" value="TRANSLATION FACTOR GUF1 HOMOLOG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP-binding protein LepA C-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g401.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18090" checksum="440F8EE5593B49B4" modified="2023-02-22" version="1">MAEVVLDFFDKLKSVSRGYASLDYHFVRFDAGPFVRVDVLINGDKVDALSLIVHRSHADRRGRELCEKMKDLIPRQMFDVAIQAAVGSQIIARTTVKGHAQERAGQVLWWRRFAQEEASGKAEGRQEAHEAGRTRGDSAGSVPGRPADGQQVSPHRPCGPVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YTZ9</accession>
    <name>A0A914YTZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YTZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4134.t1">
        <property type="protein sequence ID" value="PSU_v2.g4134.t1"/>
        <property type="gene ID" value="PSU_v2.g4134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033130">
        <property type="term" value="F:acetylcholine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900075">
        <property type="term" value="P:positive regulation of neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16478">
        <property type="entry name" value="RING-H2_Rapsyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052480">
        <property type="entry name" value="RAPsyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46574">
        <property type="entry name" value="43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46574:SF1">
        <property type="entry name" value="43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4134.t1"/>
        </source>
    </evidence>
    <sequence length="292" mass="31849" checksum="CB63A65C1F87320E" modified="2023-02-22" version="1">MKCHQRLQELYVQLSDEDSEDVARKTAITLIQEMELFCNFCGQRYGLNDESLQALRCSHIFHEKCLHEFLHERESPTCPKCSCKAILMENVSLGTSSASSNNENEATAQQQPSSSKEKKQAIIEPPQGGIQTCFLQASIVPNHLPPSTSEENSFTQSFQSDPAVTIHSAKPVILVHSPSQETSDDATSLKIRTTRPRIVPTGSATPVICRVNQFNDNHAIPSAVVTRQKSPLATIKGPKPPPPPRKPNCSSRIHAFPPLPPELLTGIGATPISQNSSSTNTIRPQGPGVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YU91</accession>
    <name>A0A914YU91_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SNTX MACPF/CDC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YU91"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3236.t1">
        <property type="protein sequence ID" value="PSU_v2.g3236.t1"/>
        <property type="gene ID" value="PSU_v2.g3236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056072">
        <property type="entry name" value="SNTX_MACPF/CDC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24674">
        <property type="entry name" value="MACPF_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNTX MACPF/CDC-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3236.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25604" checksum="F925265D543CC44E" modified="2023-02-22" version="1">MKHLISSSNFGELNGTHVVVGISWGTNTALSMAYNYTINDSQTALAEKQLQHVCDKFKKLSIENDSNEFVADDIIFENGDGLMLNIYADLTPEGLKIPTNLKEAKEYFNQMAQSYANFKGTPMELILLPLNIVQRVFGLQQNFAGNRISNNIEMPTIKRLEQLFDIIYQSSANFENLVKLCTENEGFFAEEDKNEVKNYANKFESGVNEMRGELAVLVQNVSSFSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUZ9</accession>
    <name>A0A914YUZ9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamate decarboxylase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YUZ9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3495.t1">
        <property type="protein sequence ID" value="PSU_v2.g3495.t1"/>
        <property type="gene ID" value="PSU_v2.g3495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009449">
        <property type="term" value="P:gamma-aminobutyric acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF10">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3495.t1"/>
        </source>
    </evidence>
    <sequence length="505" mass="57923" checksum="CBC2EE954D9C70B9" modified="2023-02-22" version="1">MSPEEVLKKIENLHATDLLPQSPENWEDSRNFLQQVVEILYDYIKEENNRESKILDFHQPEEMKKLLDLSIPEKPMNLGELLKSCSEVLRYSVKTGHPRFFNQISCGLDLVSMAGEWLTATANTNMFTYEISPVFILMEKEVVSKMVELIGWAPDQGDAIFTPGGAIANLYAVNAARHFHYPRVKPLGMSTVPTLCTFTSEDSHYSIKSAAAVCGIGTDHCFNIPTDNVGRMIPEALEEKIVQCKREGLHPFFVSATAGTTVYGAFDPLPKIADICERHKIWFHVDAAWGGGLLLSPEYRHKLSGLERANSVTWNPHKLLGALLQCSACFIRHDGLLFQTNQMSADYLFQQDKPYDVSYDTGDKAMQCGRHNDIFKFWLMWRSKGMEGYRQQINRLMHLTAYFTDRIKRTEGYEVLIEKPEYLNICFWYYPPSIRHLEEKEKNARLEKIAPKIKAKMMERGTTMVGYQPDKQKPNFFRMIISNQAITYADLDFLIDEIIEIGKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVC1</accession>
    <name>A0A914YVC1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cation transporter family protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YVC1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21454.t1">
        <property type="protein sequence ID" value="PSU_v2.g21454.t1"/>
        <property type="gene ID" value="PSU_v2.g21454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="166"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21454.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="33006" checksum="9BDFB66F693A3CA0" modified="2023-02-22" version="1">MYSEIWLDPRLAFKHLNVCATNITLKSDFRTKIWNPDTCIINSKESSIHSSPSENSFIIVYENGLVWSNFRLKVKAPCHMDLKMFPFDSIQCELVLESYSFNVDEVKLQWHDIPITMMEKVELPDFDLIGWSTDHQELQYPNGNWQRAIVKFTFARRYGFYLFQSYFPTSLTVISSWVGFFFDVRSVSARITLGVSSLLALTFQFGNVLRHLPRVSYIKCLDVWMIFSVIFIFCTLVELAIVCQLNRWERERQIGSKVLGHWLNQIRKTRKSDAKLQQMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVD6</accession>
    <name>A0A914YVD6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRAF-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVD6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4102.t1">
        <property type="protein sequence ID" value="PSU_v2.g4102.t1"/>
        <property type="gene ID" value="PSU_v2.g4102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.150">
        <property type="entry name" value="TRAF-like zinc-finger, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031890">
        <property type="entry name" value="Fbxo30/Fbxo40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043013">
        <property type="entry name" value="Znf_TRAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933:SF20">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4102.t1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41689" checksum="A9B2095971A93D83" modified="2023-02-22" version="1">MWDYEPCDDDRGYGLSIDEIKDAHNEHGHCAFCFDLNCIEDDICKIVPCNYCKIKLHSCKVEDHQSICTKASSPCINANFGCPEILRNELRGIHLSKCPASAVVCNLQWNREIIGKLAKRRMKQVSRGFKTQMLEGKLKENDIDELDVFAALDDQREIMESYRTFRHSRVRQRMACTPANPVLPLRYYDKMPIFPEEDSSDEEKFKEEQERMKKKQPFADCYICKLEPGMQHLHVLGNMYAKKDGTTGEIVATVPDLDSNLKLVVPKFYQKRNLFVKLSEARMSDFHRKAFQYRWTREMHTFTCTAVMRRDEISNHWKYHTDVLQLIDGGIIKRCPSAPNGCDFYVRQLIPKNGGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0B4</accession>
    <name>A0A914Z0B4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0B4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6174.t1">
        <property type="protein sequence ID" value="PSU_v2.g6174.t1"/>
        <property type="gene ID" value="PSU_v2.g6174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="118"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6174.t1"/>
        </source>
    </evidence>
    <sequence length="530" mass="59512" checksum="1EA7419F1533EFDD" modified="2023-02-22" version="1">MNNKQQKTRWHPDALHNAKKDFSAIDLDKEEDHSNGYNKLFNGFEWRQPSLYHILSINALCGSIFIQRGTCKSSLNLMNVGRRFFHTAQNHRLLIRQKTSTDAQLRAHERSVTLTDCAISKIDVSQLAANRPIEDYHSAATCLSSNAHLIGVFDGHGGASCSRHVSARLFDYMCASVLEKHIIKNLPLMDRLQWLFSSGDHRLPSFVKEQHIRNVQNFFDRFKSDPDLKSVRKAIQAAFIALDDDITQGAMPDNVGRVDRIAANVAASGSCATVAHLRKCHLHVGNIGDSAAVLGVSQQYSMTARQLSRPHCVENDDEVQRIRHAHPISESSTILKGSRLLGELYPLRAFGDVRYKWTEDLQRVVLEPLGVLPPHGLLTPPYLTAMPEVFYHKLTSNDKFLVIATDGLWEMLEPDSVIRLINDHTLGTQTLSLYQPEQGISLLDVCKNLEKRKQGESKKPLDDNSATHVIRNALGGVSGGIELQYERLKESLQLPPGMARHYRDDITVIVIHFNEDYLSSIAESEDPCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z137</accession>
    <name>A0A914Z137_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z137"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5838.t1">
        <property type="protein sequence ID" value="PSU_v2.g5838.t1"/>
        <property type="gene ID" value="PSU_v2.g5838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF2">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="265"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5838.t1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42579" checksum="251F96602E057DDC" modified="2023-02-22" version="1">MGRKQPVRKQTTAEGRGSKENGTKRQSTVRRQSKVASQQEDDGTQIETGAPKKSSGTKRVKRKEVEKTLNESNAYAQSLKQFTLATCETGIQALVEEFTRIKLMGQANIPAKTAFDANPEKNRYKDVFCIDESRVILTWPPGCTSDYVHANWLPVRGEKKFICTQGPTDKTVDDFWRLVWQEKTKAIVMLCGIMELGKKKCEQYWMDKAGEQMKVQSGITIKTTDVSETEKNLTLTKLELSVEGHDNFVVHHFLWKEWPDRGVPENFMACFRLLQRLKTYSPPTLVHCSAGIGRTGTICGLDMANQILNVGDRLVMADVIKELRQHRHGSVQTDVQYIYMHRVLIGLAENKKLVKHEEIAPFYESYENFIKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2G9</accession>
    <name>A0A914Z2G9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z2G9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6906.t1">
        <property type="protein sequence ID" value="PSU_v2.g6906.t1"/>
        <property type="gene ID" value="PSU_v2.g6906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF480">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6906.t1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33201" checksum="BE7C042CF8BFE594" modified="2023-02-22" version="1">MVTSQTSPGSDPLFLWLTGGPGCSGLGALLTELGPFRPNPDNRTLSENVFSWNKFANILFLESPRGVGFSFQNMTENNDTRWDDDRSANDAYLALKDFFSVYTEFQNRPFYIIGESYGGVYVPMLTSLMVQKIQSGEMKNVNLVGMAVGNGELNSIIGSNSLLSDMYYHGYIGTGEWATLAQCCNTTYQMLPFCPFDARYTVSPDGTAIPKDNTSACDNLIADKINNVWTDDMLYYSDVYNQNQDCYQQTSYLLGSIRSAKTRQKVAEHTRKFIKAQKDASVTNYVDAYRYNNDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2L8</accession>
    <name>A0A914Z2L8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Desmoplakin SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2L8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6598.t1">
        <property type="protein sequence ID" value="PSU_v2.g6598.t1"/>
        <property type="gene ID" value="PSU_v2.g6598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049538">
        <property type="entry name" value="PCN-like_spectrin-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21019">
        <property type="entry name" value="Spectrin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21020">
        <property type="entry name" value="Spectrin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Desmoplakin SH3" evidence="4">
        <location>
            <begin position="442"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="624"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="871"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6598.t1"/>
        </source>
    </evidence>
    <sequence length="994" mass="117379" checksum="E80ED491DEFBCAFC" modified="2023-02-22" version="1">MYEKELPTNFEELEKLMKQLNKFQDEDLPPMASEKDRLKAIYEELVHAFKGTNFLHVPFELQPKGLEDAWEELLKAMEFRNEILHEQLGIQDDLESSKFQGNLDDIISRLTRGIGIVNEKLDLILRRIEEVEAKADTADPAEIRRAVQELVDDLEAIEAPINDLFDDVDILKSHNHPKTDEFYRQVYGLHQRRTAYLDRLNNQILTRIGIRTDTMSRRSEERTKSLFHNLEEAIRWVREKAEKLDNMVFHEDLETLEELFEQHKIDNRDIQDFDQTVKECIARQAEISAEESHEYCELLAVLESEYQQLRDLSAGRMLDLDSLIAFIRAAQLELIWIHEREDIEVTRNWSNIERLDLPMLQNYFKQLLHEMNYVKNFQEEVAVIEEWIKSQTEHLENNYNQTNFSVEEGERWLRELNEIREVIQRYHTLLMTLAERSAQISPLWQRGERIRQPIPVTAWCDYKGKDIEIRAGDEVTLIDNSDLINWVVRGVDGVQSTVPSVVFRIPPPDPQLTNHLARLAAQLDKMRKLWDRKHRMIRFNMMISTMKSIQGWDLDTFLSYPPEQRDEIIKALNDDVNKLLAEMDPNDPLALRLKEELRRTNDHFLDLLNQSLRGPESDLSSQFDERLADLLKKLEEAWKKLNERTAEGVPKTVEDLERLVNDHRAFEEALQNLDSEVSNVKELFRQIPNPTPQQRANHDYLNSRWEDIWDLSRMYVERLKILQQVLQGIDEVTDIVRRHEITLSSFDDMPSALDSLRGVHAQLLELNMVLQQQEHIIHQLNKNTAQLRQHVARTRFNVASHPDVDRLEEQVQQLTVRWDNVCSQVSDRLKVAEESQQTQMVYRSQYDEEIQWLDRVENTINKLRKPESLSPDELQQQLEQLMAEYRQLQEHTATIENINKEGGKFIREAKNYDNSLNTFREHITSIHGPGIRNDFRRTQPQPKNGAQIVTEELEALNRRFAELSSVILERRNQLNILIQNWKRKQQKKKNLHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z316</accession>
    <name>A0A914Z316_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z316"/>
    <dbReference type="WBParaSite" id="PSU_v2.g645.t1">
        <property type="protein sequence ID" value="PSU_v2.g645.t1"/>
        <property type="gene ID" value="PSU_v2.g645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g645.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18508" checksum="BF4521EF5196C47B" modified="2023-02-22" version="1">MSSGGPYTPVLRKSRCKPLTPEQVKHILENPYPTGYTYANSSSYSINNPREYINPNLSRSSLLSSSCSSSYDFDEEDSSSSYIAKPFWFIISLAAVMFQGFGDFFNTNGYMMMQLKKILEHFFRDMMGKINGRPGLSFVDFYLFFWFLENISTTRCSSSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z358</accession>
    <name>A0A914Z358_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z358"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6790.t1">
        <property type="protein sequence ID" value="PSU_v2.g6790.t1"/>
        <property type="gene ID" value="PSU_v2.g6790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="259"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6790.t1"/>
        </source>
    </evidence>
    <sequence length="510" mass="58099" checksum="1EA0DA6B28DBB487" modified="2023-02-22" version="1">MVEKMEVDEPVLPKEKETETKKEEPTKADLNAITYENLKDWCAQLERGETHIVGRVIQFLSKTRKELNVDILSKLITTFVSDKTHRDLLLGYIGSTGAPSTPTPMEVDKAKPSGARSPRPDRRPPTTPSKGGNAEVELYIQLLVMLYLLDQGKLENVDACTKNYIAKIDQYEKRSLDPFLAKGFFYMTLVAERQNKISDLRGYLNSRLRVATLRNQTDTVAILIVCLLRVFLLTKNFSGASKLLTKVSFPESANNNELARFLYYQGRIKAIELDYNGAAQFFQQALRKAPSDSAVGFKQNVHKWIVVIQLLQGLIPERSVFRVAAYKKPLAPYLELTHAVRLGDIIQFNKIVDTNKPVFTQDETITLIVRLRQNVIKTAIRQISLAYSKISIKDIARKLALSSTSEAEYMVTKAIKEGTIDARVSFDTTADDRYMQTVETENIYRTTEPQFSYDERIKHCLILHNHAVKALRYPSDKGKAGIESIEQQREREQQELDFARDMADEDDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z379</accession>
    <name>A0A914Z379_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z379"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4709.t1">
        <property type="protein sequence ID" value="PSU_v2.g4709.t1"/>
        <property type="gene ID" value="PSU_v2.g4709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4709.t1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15404" checksum="03527131C87E0132" modified="2023-02-22" version="1">MVREVHAGKLRLKSGVKVNVAIKMAKMEALTKEQIKEVMREARLMRGFDHPNIVKFYGVAAGTEPLMVLMELVDCGALDSYISKNPNLEPIKRVEMCCQAAWGIEYLHFKSVIHCDIAARNCLYGDGKVWNCPFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3S0</accession>
    <name>A0A914Z3S0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3S0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g666.t1">
        <property type="protein sequence ID" value="PSU_v2.g666.t1"/>
        <property type="gene ID" value="PSU_v2.g666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g666.t1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25677" checksum="34C9B635A951B01C" modified="2023-02-22" version="1">MSLVEKGFVLSPTEMLYVSFNHEAKDVQQQIAFKKTYELAKKQALKIQELFPEENFNLVDSIKGYLIDVIPHAEFSRMPKSFITDFVVANGIISEEQANHIFDIRVKIKNYGKIVNGIIKEDDDIGIRGAIEKMKFCKMTRQSTTKIRFLKLKFTIPLTPSFVQKMKGCEWYLCLESDGILTFKHHSIVQISDYLLAEMKSNAKFQLTPGKTTFLFARFNNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3V4</accession>
    <name>A0A914Z3V4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="14">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z3V4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7384.t1">
        <property type="protein sequence ID" value="PSU_v2.g7384.t1"/>
        <property type="gene ID" value="PSU_v2.g7384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000399">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="158"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="282"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7384.t1"/>
        </source>
    </evidence>
    <sequence length="560" mass="63461" checksum="1FA09DC10E4B9D71" modified="2023-02-22" version="1">MGSCFSRPQDGISSTSQMPQQFSSIHGTAMNGGGDSQLFSSLANQRRIAQMNVYKDDSSLARKMTPMGSMYYGGMPMPQNGTISSLDSRGQHSSQKVIALYGYESRVDGDISFKKDDIMVVLEETNSDWWYVRHSKNGLGFVPRNFIAPLDSLEREEWFSGKITRSMAEKLVSAPNLPRGTFLIRKRDHENEYALTINDAENARLYGQNVKHYRIKPLDNLDGYFITTKKIFSTIKDLVSFYSEESAGLCCKLTYAAPKLAPQRTDLSSDTKNNWEIPRTELQMIEKIGTGNFGAVYAGLWRGKVEVAIKTLKPGTMSPEAFLKEAQIMKQCQHPKLVRLYAVCTREEPYLIVTEFMKNGSLLDYLKKPENHLSHKALVDMCSQIAHGMTFLEERKLVHRDLAARNILVGDKISGIPEVKVADFGLARIMEEEVYEAAMGAKFPIKWTAIEAATYGNFSVKSDVWSYGILLFEIFTRSAPYQGMSNKQVIDEVERGYRMPKPAEIEDAIYERMLQCWDKDPERRPCFAFLHSFFDDYTVSSQPSYVPSSIDDPSFGGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z413</accession>
    <name>A0A914Z413_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z413"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6741.t1">
        <property type="protein sequence ID" value="PSU_v2.g6741.t1"/>
        <property type="gene ID" value="PSU_v2.g6741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF362">
        <property type="entry name" value="G PROTEIN ALPHA O SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="242"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6741.t1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33795" checksum="3444BBC0A0F98A3C" modified="2023-02-22" version="1">MGNCESSTHDKQIHPLKDEPVNLQNRGIPSSGDSLQSPPPHVFDSIKGGQAFSLEPASLTNPSETINTSDWSNVKDALNRNRQIEEQIMKDHRKLEKVIKLLLLGPAESGKSTILKQIKIIHLHGFSMADLAEKKPLIFRNIYESIIQLIKGAHSLGFELPANLQADIDTFCLFFNDYQFGDQMEFPKTMYPVVKRIWANERIKEVYVQRSDVYVMDCAKYFLENIDRICSESYIPITSDVLYSRQQTVGVSEIRYNYKDLEFRIFDVGGQKNQRRKWIHLFDNVTSIVSAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z498</accession>
    <name>A0A914Z498_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z498"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5077.t1">
        <property type="protein sequence ID" value="PSU_v2.g5077.t1"/>
        <property type="gene ID" value="PSU_v2.g5077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5077.t1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18536" checksum="28ACD3F794694557" modified="2023-02-22" version="1">MGSFAGYFKTRVECQKLCKQNYQEKCYGYMYEPQKRGTCSIFQYSLNANFYNSPNSKVSLFKKCGDAVVTGCCGELTQSSTSFLANGDMSFTYNDNKCRSTATVTCGQPKGLGFEKNAAIVVNRINYLKIGWLGETIHAQASCSNGTWKMGNPPLIVSTLECQLSDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4J9</accession>
    <name>A0A914Z4J9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 29</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating and therefore sperm motility.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z4J9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6820.t1">
        <property type="protein sequence ID" value="PSU_v2.g6820.t1"/>
        <property type="gene ID" value="PSU_v2.g6820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051476">
        <property type="entry name" value="Bac_ResReg_Asp_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6820.t1"/>
        </source>
    </evidence>
    <sequence length="521" mass="59641" checksum="59784AB35DFFFEFF" modified="2023-02-22" version="1">MNDYLSAKECYKLALTENTESYNANFGIGNILFKKNDISDAIIAFIKAQEVAPSQDYRQLALIRICQCKIILGQTDEAINLLKTNLKTEKLLNPHILGNVLGIMCRAAEASDDVITFHRMAKRQLKLAIDTKNNLLKSEAFFSLSKFYERTNQKSNAKRLLELYLEIVETSEINHNPEQQILALLRLGKIEFENGNWETAISIAQKRLILIKNLNNIEMEANAHANLISIYRKMANMEKCKEHINALEGLKNSAAENNTLLEVASIYDIEMGEMFMENKEWEKAKETFEKALIVVQELDKTEKEAELCEKLGIVHYKLERSEEALIYFNQFLMISQQQKNANSMLNAYGHLTQVHLKLQNLEEGFDCAKFLLTLSDILNNSKEKITALLSIGRIFSKKEEHTIAIKILSKARRLAEKMDSKRELALCFGYLGECQLKINQRQKALTNFCKQLNYFPYINDAEDKCETIAHLIEEKILTNDVVWCAKLCRLQEDIAKEGPITLQMKVLRESAAKNAFFGVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z4S9</accession>
    <name>A0A914Z4S9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z4S9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7693.t1">
        <property type="protein sequence ID" value="PSU_v2.g7693.t1"/>
        <property type="gene ID" value="PSU_v2.g7693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052861">
        <property type="entry name" value="BPTI/Kunitz_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47248:SF6">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47248">
        <property type="entry name" value="PROTEIN CBG06772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037479218" evidence="1">
        <location>
            <begin position="20"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7693.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34191" checksum="6D0FBBE8FA286835" modified="2023-02-22" version="1">MKQYIFVIIFTCFVVYTLSQTTEPKSELEEKCKLEAEPGNGTDESIRFFFDETSQKCQNFTFTGEGGNENNFETELDCLNDCFVGVESEGTPQNEEDVVFVEKDQPVLEWECDKPKETGNGQDSIQKFYYNSKWHTCFAFKYSGEGGNGNRFSTRSECESNCAVADGSVCTGPSGSKELLKIGGSCDEAECSEGHKCANGLRGPECCAKDELDAIETGFSDTCPDGSKADGIFEEYFQATFAETCDDLLCNDGQSCIQVNKYFAKCCGGEKRLADDIPVSAGALHVQIDGEQDAVEDREDFMPSRLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z5B2</accession>
    <name>A0A914Z5B2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Cell membrane</location>
            <topology evidence="1 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z5B2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5438.t1">
        <property type="protein sequence ID" value="PSU_v2.g5438.t1"/>
        <property type="gene ID" value="PSU_v2.g5438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090533">
        <property type="term" value="C:cation-transporting ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000038">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000004">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 20" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 20" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="934"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5438.t1"/>
        </source>
    </evidence>
    <sequence length="972" mass="107817" checksum="593800BE99151614" modified="2023-02-22" version="1">MERYNSDIDRGLTTSEAEKKLSRDGRNELSPPKTTPNWIKFCKNLFGGFAMLLWVGAILCVIAYGVDYVNMDHPSKDNLYLGIVLMFVVIVTGVFQYYQENKSSKIMESFKTMVPTIAHVYRDGQIIELETGKLVVGDVVEIKGGDRIPADIRILQAASFKVDNSSLTGESEPQSRSPECTNENPLETKNLAFFTTNAVEGTARGVIVNTGDRTAVGRIAGLASDLESGMTPIAREIEHFIHLITGVAVFLGVTFFIVAFLLGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVSHMWYDKNIITCDTTENGGKNYEQSTRSKTEDALLRCAALCNRAVFKSGQGKSSILKRECSGDASEIALLKFCEINFGRVAEFRTENPKIAEIPFNSTNKFQISIHETSDGHDSYLLVMKGAPEKILDACSTMLVDGQEVELNDRHRADFNDAYLDLGGMGERVLGFCDFRLDPVIFTQDYRFDTEEINFPIDGLRFVGLISMIDPPRAGVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDSSVTVEDIAERRRIPIERVNPLDANAAVIHGSVLRKMTPEQFSQVINHYQEIVFARTSPQQKLMIVEGFQKQGEIVAVTGDGVNDSPALKRADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLMYIVFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRLPRDPLHDKLVNERLISLAYGQIGMIQALSGFFTYFWIMADNGFLPWDLLYIRAEWDSRAVNCVVDSYGQEWTYANRKVLEYTCQTAYFVSIVVVQWADLIISKTRRNSIVQQGMSNWTLNFGLVFETVLAAVLCYCPGTDLGLRMYGLKFTWWFCALPFAILIFIYDEARRCCIRTWPGGWVERETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6J1</accession>
    <name>A0A914Z6J1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6J1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7542.t1">
        <property type="protein sequence ID" value="PSU_v2.g7542.t1"/>
        <property type="gene ID" value="PSU_v2.g7542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7542.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11681" checksum="1E9D2A8A3E1E4EB8" modified="2023-02-22" version="1">MKVAIDAFVKQVLQKGIKGLLKDFTSIRIAALPEKEEISQWIAHPELNRYKNILCWDKSRVILKEHPDGNSYIHASIVGSPLYPDRFICAQGPLPHTVSIFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6R4</accession>
    <name>A0A914Z6R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6R4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8023.t1">
        <property type="protein sequence ID" value="PSU_v2.g8023.t1"/>
        <property type="gene ID" value="PSU_v2.g8023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8023.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27518" checksum="9EA82BFEFD0BFC9E" modified="2023-02-22" version="1">MAYCAVEAAKSDDVSTLQKYIQKLNSTCRDMPIIYFVCKDIITSGKWQHLKEDLVNCMVLNCPEEELEFLSEVLKSIDITRRFPSSLQKTSSDSTMKETFTKFTTSFLDPLTKKENTNISFKDDDELHLDPMYTSLNHFHQLSKGTVPPPIAVVEDGNEMLLESAKQWIPYSTTAAIVTAALAEDTTTKWAKHDILNKAALGLKKTKNKSMIMDIQEVAKQFNVSIWKLNMSLVEYILTEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z6Z3</accession>
    <name>A0A914Z6Z3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z6Z3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6018.t1">
        <property type="protein sequence ID" value="PSU_v2.g6018.t1"/>
        <property type="gene ID" value="PSU_v2.g6018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34311">
        <property type="entry name" value="PROTEIN CBG21698-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34311:SF5">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036987198" evidence="1">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6018.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29130" checksum="65816E7D6057AE51" modified="2023-02-22" version="1">MKFIFAVLFALVFVQTDAVCPDTNLLHCTDTFVNYVGYPITHNAVWKDYQTFINFTDNLFTQNVGDPSGLVTICNALEQLKGCVVPYDCFSPFAFLQRQSSAVDAFIFSGLFQEYNFRCGAGLYTILRENFPCVQRVVAGHSGQLSGCLTTYISNLQHDMQNACTHVGNYMTCVSAIFNQSACGFAGSTDHWWACESAYQLTQPGFPNCKVSCANGGPAGLKDFMVQNTKIENGQFWLKPHPIFKNINGKWQLTENEWMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z783</accession>
    <name>A0A914Z783_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z783"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7766.t1">
        <property type="protein sequence ID" value="PSU_v2.g7766.t1"/>
        <property type="gene ID" value="PSU_v2.g7766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057657">
        <property type="entry name" value="MAT1_CAK-anch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25811">
        <property type="entry name" value="CAK-anch_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="119"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7766.t1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35764" checksum="2817AFDEAA62669A" modified="2023-02-22" version="1">MGRTTITRQCPKCKTTDNSNRSLTMMINECGHPICKNCVENIFARNSGPCPVCGKPLKKNDFWEQKYDNPIIERELFYRKRLAKVFCLKEDEFPTLRAYNDYLEKIEHYVCNLVDGINVEETEAEITRFKREYADAIERNRKKLSEDDLWIKKMLEEEAELHRRVNAELQNENAQQKKKTADEVNKEVLEELKTGGLPAEVIVDKRRKQQIEQEILARDAEKQKKLIKMATRQEKVTFGAIASAGAPYVHVLPRLYVSGPQLPTYEEMKSLGYLNYSVAPTKDKLAGGFIPELPLSRALFEARQDLFAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8G7</accession>
    <name>A0A914Z8G7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CTLH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8G7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8146.t1">
        <property type="protein sequence ID" value="PSU_v2.g8146.t1"/>
        <property type="gene ID" value="PSU_v2.g8146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057749">
        <property type="entry name" value="WDR47_COR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25602">
        <property type="entry name" value="WDR47_COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="584"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="721"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="763"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="809"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8146.t1"/>
        </source>
    </evidence>
    <sequence length="845" mass="93514" checksum="810C2B3260CDAC99" modified="2023-02-22" version="1">MKHLTDFKLKKLKETGVINGEFSDDILFLRQLILDGQWDNAIDFVDPLTEIPEFDLRSFKYLVTKYKYFELLCIKQEPGPMHDNDFAVEEIVECLKDLEQISPTPEDYRQLCALLTLPKLSDHVDFRNWNPSNARVECFHKILPLVSSLLSNISSSAKADPIPSSINERLLQLITKGIFYEACIDFCQAQALGNNKAAENGPQLTQPKLEAPWGEHILITPMKPGGQFPHSLVPTSRLKCAQKMTQSLILPSTASAFSMEASIIGKARKERAAHPMSHSMAPDVGFSIPSLPAAESAMQQSQIITNMFESSELTKTSRPLNNSLSLPLPLGTSSSTTESRRELDAITRKNQISRGSALPPVPELSTPTADIPIENAMTQSRLFQEFSNRQRIVSLPQTSNSMQAPPSMAMPQIPPPHSGRLSYDPLIPSQMPPQMQILSDPYQMQLPYGPPPPQQQQRPVSTIIPAIPSNPYDSISRPQSMIGGNNGYNHHHPYPPPPSQQPPSSMNSMGPSSSSNSLPVHFVPLCRYEDSQAIRAVSFHPSGRYFAVGTNSKQMIICRYPDVRKAALNNRSLPFGPEICLNRPKQHRGSVYCCGFSPSGELLATGSNDKTLRLMSFNAEECKIGAEVELTMHDGTVRDLIFLDDLNHPPVLVSGGAGNCKIFLTDTSTGQTFKELTGHTAPILGLYGWGGCTFSSCSQDKSIRFWDLRAANAVNVIQPNARTSNAPVTSVCVDPSGKLLVSGHEDASIMLYDITGGRVIQTFRPHGDEVRTVRFSNAAYYLLSGSYDRRIVITDMRGDLTNPLMYLPVAEHNDKIIQCRWHPQDFTFLSTSADRTVVLWSLPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8J3</accession>
    <name>A0A914Z8J3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8J3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8644.t1">
        <property type="protein sequence ID" value="PSU_v2.g8644.t1"/>
        <property type="gene ID" value="PSU_v2.g8644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF10">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8644.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10985" checksum="742FB313600CDCEE" modified="2023-02-22" version="1">MDDQYYDPTNPKYKCCCGCHVTIATRIICWINIIIVAVIVLCTIYFNDEGPYDEPEINGSSVVLLIIAALVPVITAVTPLYGLKVENHKWLIPFLVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8K0</accession>
    <name>A0A914Z8K0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-dependent oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8K0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8173.t1">
        <property type="protein sequence ID" value="PSU_v2.g8173.t1"/>
        <property type="gene ID" value="PSU_v2.g8173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF287">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="4">
        <location>
            <begin position="93"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8173.t1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60222" checksum="329C0DA07E6401F8" modified="2023-02-22" version="1">MRSISQISSRISAVRSFQTSSIRLWEKYENERYYAPGEDPLKRIWHGLTYDFKRWKRRYEAARNDAFKRYNPISHTKSSNVFDYELMPFRTEVLIIGGGLTGSSTAYWIKERFRDEDFKVTVVESPDRLENTRSMLSSGPITQQFSIPELIEMSLFSAEFLRHAGEHLQILDNDPPDINILPVGFMYLARNEEEAEIMKENWKTQLERGAKVAYLTKSELQARFPFMNFDDVIVGTYGLENEGLIDTWQLLSAIREKNMTLGVQYIKGTVEGFKFENLGIRPEPHYLQEGDEADYSAIDERKLRAVLVKPQMVGASARPIETHFIVNAAGPWAGEIARKAGIGCGAGILAVPVPIEPRKRVNFVIHAPDVPSFDIPAFTDPNGIFCRPHDAGNNFICGKIPTRAEDAKTNHSDMSVDYNEFYNDIWPFLVKRVPAFKNSKVVNAWAMYNDVNTFDDLPVLGENLKYNNFYTMAGFGNYGPQMAIAAGKLYSERIFDSAYVTINVRKYDMRRIMNQKKYKEPLKCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8W9</accession>
    <name>A0A914Z8W9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8W9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6692.t1">
        <property type="protein sequence ID" value="PSU_v2.g6692.t1"/>
        <property type="gene ID" value="PSU_v2.g6692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6692.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12414" checksum="A5AE2A571AB98A2A" modified="2023-02-22" version="1">MTSSLSNKVALVTGSSRGIGRGIALQLGAAGAKVYVTGRRPENHEAALKDIQPNGLETVAQEITKRGGKGVAIFCDHSNPEDVKKLFERIDKENNGQLDILVNNAYAGVNKRTSAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8Y1</accession>
    <name>A0A914Z8Y1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8Y1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8287.t1">
        <property type="protein sequence ID" value="PSU_v2.g8287.t1"/>
        <property type="gene ID" value="PSU_v2.g8287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037300083" evidence="1">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8287.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="12800" checksum="C3ABC47589B642CA" modified="2023-02-22" version="1">MKVAVLILIFVAVAAGHVRRFRHGRAVTTIHNTYGSVRTPGVPGVTTYNNLHGSTVLGPRVNTFGHNNLHTSGIGRVNHVNTVHNSAVGPHGALINRHSNIGGAGIGGTHGAITGHHINTLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9X6</accession>
    <name>A0A914Z9X6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914Z9X6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8726.t1">
        <property type="protein sequence ID" value="PSU_v2.g8726.t1"/>
        <property type="gene ID" value="PSU_v2.g8726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8726.t1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33286" checksum="C2796718BCB59929" modified="2023-02-22" version="1">MAEVEYTPEQIDKVGESLNDSSLPLAARFRALFILRNLKDDQSVEWIGKAFFDSSALLKHELAYCLGQMQNKSAIPVLSEVLKDVQQEPMVRHEAGEALGAIGDKASLDLLKKYSEDPLPEVAETCQLAYQRIEWVHKEGKDTNSPYDSVDPTPSSVVKNVQELKNILVDPSQTLFDRYKAMFTLRNINTDDSILALGEGLHCPDSALFRHEIAYVLGQIQSPLSIKDLAIGLKNDKENCMVRHECAEALGAIATPECEELVREYAKDIDEVVRESCIVAIDMSEYEKSGNFEYAKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZAR4</accession>
    <name>A0A914ZAR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein FdhE</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZAR4"/>
    <dbReference type="SMR" id="A0A914ZAR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8856.t1">
        <property type="protein sequence ID" value="PSU_v2.g8856.t1"/>
        <property type="gene ID" value="PSU_v2.g8856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16341">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1670.10:FF:000001">
        <property type="entry name" value="Protein FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1670.10">
        <property type="entry name" value="FdhE-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00611">
        <property type="entry name" value="FdeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056796">
        <property type="entry name" value="FdhE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056797">
        <property type="entry name" value="FdhE_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056774">
        <property type="entry name" value="FdhE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006452">
        <property type="entry name" value="Formate_DH_accessory"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01562">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002925">
        <property type="entry name" value="PRK03564.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37689">
        <property type="entry name" value="PROTEIN FDHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37689:SF1">
        <property type="entry name" value="PROTEIN FDHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24860">
        <property type="entry name" value="FdhE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24859">
        <property type="entry name" value="FdhE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04216">
        <property type="entry name" value="FdhE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018296">
        <property type="entry name" value="Format_dh_formtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="FdhE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FdhE N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="FdhE central" evidence="4">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FdhE C-terminal" evidence="5">
        <location>
            <begin position="227"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8856.t1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34689" checksum="F9A0B147A43446E6" modified="2023-02-22" version="1">MSIRIIPQDELGSSEKRTADMIPPLLFPRLKNLYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEASAQGKPPLDIHVLPRDKHWQKLLMALIAELKPEMSGPALAVIENLEKASTQELEDMASALFASDFSSVSSDKAPFIWAALSLYWAQMANLIPGKARAEYGEQRQYCPVCGSMPVSSMVQIGTTQGLRYLHCNLCETEWHVVRVKCSNCEQSGKLHYWSLDDEQAAIKAESCDDCGTYLKILYQEKDPKIEAVADDLASLVLDARMEQEGYARSSINPFLFPGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZB50</accession>
    <name>A0A914ZB50_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZB50"/>
    <dbReference type="WBParaSite" id="PSU_v2.g954.t1">
        <property type="protein sequence ID" value="PSU_v2.g954.t1"/>
        <property type="gene ID" value="PSU_v2.g954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01518">
        <property type="entry name" value="RHOD_YceA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF3">
        <property type="entry name" value="RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="127"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g954.t1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21759" checksum="CB4B97FCEEEC3F82" modified="2023-02-22" version="1">MCEAHFTVAALYCFARFPDFEAYQAPLTELCDQNGIKGTLLLAAEGLNGTVAGTQSGITALIAFIEAIPALREQNIELKYSTASQMPFNRMKVRLKKEIVTMGVEGIDPLQSVGAYVQPEEWNALIDDENTILIDTRNDYEYAIGTFKGAIDPKTKTFREFPQWVEDHRGDLEGKKIAMFCTGGIRCEKATAFAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBG9</accession>
    <name>A0A914ZBG9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZBG9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7598.t1">
        <property type="protein sequence ID" value="PSU_v2.g7598.t1"/>
        <property type="gene ID" value="PSU_v2.g7598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040264">
        <property type="entry name" value="T15H9.4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31327:SF7">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31327">
        <property type="entry name" value="SPERM MEIOSIS PDZ DOMAIN CONTAINING PROTEINS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="105"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7598.t1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30356" checksum="6E492096149321AF" modified="2023-02-22" version="1">MGESGKELVIEIQMEEGEPLGATPNDKMFIVKVQAGTLSEGKLKVNNTTIRDTNHFFQLLRFAPPVARLQVVRDEKRAEELEAKVHIPAERSKYIQRRDGFVYNMVKIEWKPGGPKLGLGIKHYQNRVLVSRCDAGSLAAQQLQIGDHIIDIDGKPVTDKDVARDFLLKSLQAQGFVTCVVERPESYEAKHWTQQALAANAQQPPSVAMNSDVRDIAARERNKMKERNAQPKKSGILGRTQKSGRVQIGDKVCEYVIASDNEGKNLRSVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZBP9</accession>
    <name>A0A914ZBP9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZBP9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9169.t1">
        <property type="protein sequence ID" value="PSU_v2.g9169.t1"/>
        <property type="gene ID" value="PSU_v2.g9169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9169.t1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35459" checksum="1530E8D5C92B24C5" modified="2023-02-22" version="1">MREQLAQCKCPPSYTGKYCEIQTTTIFANETQKFKEESENIACEKDSFIFSCPNGGVILVDYALFGYSKISKSDQCLKIDKIIDSKEDFTCIDSSSLQTMIQKCQGLTYCQFPSVKDLFGQRPCPRDIPVSLNTRLRCSSESNIPNKCPPGALYIQGRCYKPFLESIISSRKTYDEAQAECGNTGGNLANPQREPIFSMLYSEIEKSAEKLNISLLNERFWVRNESDSLPSTAEWQNMCPFLQIDTNVPQPGSCQSRLHWICEYPPSGELTQRITESSLITSSSTTFSSTVPSTTSSTTIITSAKTTVSRWVHIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZDU8</accession>
    <name>A0A914ZDU8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZDU8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8448.t1">
        <property type="protein sequence ID" value="PSU_v2.g8448.t1"/>
        <property type="gene ID" value="PSU_v2.g8448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037344436" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8448.t1"/>
        </source>
    </evidence>
    <sequence length="90" mass="9999" checksum="7CD4F3513E7A1452" modified="2023-02-22" version="1">MKRFNICTLILLLYLTIAATSAASLLYRPYRQMQFDTDVPMTKRSNAELINGLIGMDLNALHDLGKRSNAELINGLLGMNLNKLSSAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE87</accession>
    <name>A0A914ZE87_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZE87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8584.t1">
        <property type="protein sequence ID" value="PSU_v2.g8584.t1"/>
        <property type="gene ID" value="PSU_v2.g8584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8584.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23689" checksum="02EF753A0B487063" modified="2023-02-22" version="1">MVSIAKEWKLSSDEEKKKFTEEAAKLRKDAIAQFEKLPKKEQQEQFVEAAKSRADLKNNRRIRAYRKFRKETNCPTRALNAFMLFRQENYPVTSKQDIYDSGKKAAEAFKNLSEEEKKPYVEKFNQQAEAYKSGYEKWYKDHGKDYEKLKKEYAKTKKVATKSTRGKKSMGLMSRLKKRRTKRKATPKRKKTTKVVAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZGF8</accession>
    <name>A0A914ZGF8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZGF8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9373.t1">
        <property type="protein sequence ID" value="PSU_v2.g9373.t1"/>
        <property type="gene ID" value="PSU_v2.g9373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9373.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25541" checksum="4E18A9C7DA55E612" modified="2023-02-22" version="1">MANENYCHKPYPHMFPEPGTILVFNVETVRAKWHLKKLIEAISETRCDGWSWTQSTGGKKRVVDGEYIMKVDHFMGKNQNTGQAEKEQPFDCWQYTTPNQQWQLLHYLGDTTHIATGYPHKNSKTGKPYLRSCPSLLRNLMSESVTDKPTVYPGYFLPESDTPRSFIDTVGLTRTNLFIHMENPLIFEEMAKVIKETGMVMRLRYDTTFKMGLQLYMLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XT87</accession>
    <name>A0A914XT87_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XT87"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10481.t1">
        <property type="protein sequence ID" value="PSU_v2.g10481.t1"/>
        <property type="gene ID" value="PSU_v2.g10481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10481.t1"/>
        </source>
    </evidence>
    <sequence length="674" mass="77393" checksum="462CAF67589D76A1" modified="2023-02-22" version="1">MVQNVRRLDSEMQQLVYENYSKFLTATNTVRNMQTEFQRMSDDMGTLTNKMDKIADLSGSLCNVFDRHRQNVRKLTDASKTVKGLQYIVKLPQRLQNFIDQKDFSRAVSSYVAVKPKLDLYKDVPSMTGICHDCNELIQEVEERLRERLTSRLISSDDLIEAVQMLKNLGIPEAELESKMVQTWKEQIEAELAILKKNEFSDILEFAENGCCNFLTTLSISANIYPQLFNQNNNQRFTAMIDEFMEEFEKLVNHRFCAEISGRECAIYVRALDRVYRKLAACDQLIFWKDYNILNNDIVVKAAAHQIAIGRKNIVSTFISTFFEVIEETRNTELSSTEISQLVQKLEQNFLVSVKTTLANLLLFTASDITFSSIDTVYFFQSFSRNVYEEIVVGSTIELEGYSRKIINNEASEFSNSSSYVFLILAQFFNLMQKKHITYLIDLCQEQFRLTERLMELTLNVTICERLDEIAKLLLKAFADIKGSEMSALCSESVNNIDWLKAPEPKIVRDEIKNIIEFVKVVSEQTNIFLSESPRKQQRSPDLGRNVTPRHAASTSTFETGSLSSALEKMWTEKVEYNTVIDFKQDTVVLAIVKIGLKSLVESSRLLLFSCNGLQQMQVDCLYLKQKLWQFVNDEHVLNSLIDEVVASVVIQCTEPRLLEPSTANLICEKSDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XTY9</accession>
    <name>A0A914XTY9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XTY9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11421.t1">
        <property type="protein sequence ID" value="PSU_v2.g11421.t1"/>
        <property type="gene ID" value="PSU_v2.g11421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11421.t1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20134" checksum="7B627B7D4BF7D63A" modified="2023-02-22" version="1">MLISEAYIPTEEDHKATDDLIDQIFKDVPLVPVKGLDNFESDNHSTSTLTRQTEFDNTPYQPVLSHPTVKHSSSSSSSASETRPLPTTHREPSPKPVPLVTPLVMNTKPSVPLNNNFQYASTSSRASSSFDAKSNGNANKNLDIFTMSAKEAQRAMLRQKKDPRKEQLTNEQKHRMIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUC2</accession>
    <name>A0A914XUC2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUC2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10844.t1">
        <property type="protein sequence ID" value="PSU_v2.g10844.t1"/>
        <property type="gene ID" value="PSU_v2.g10844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000291">
        <property type="entry name" value="ALX homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="157"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="159"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10844.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26709" checksum="16FC0FA48D6CDC6C" modified="2023-02-22" version="1">MMDYNGWISQQSPIVSVSDSTNAMNTFNLGFAAAVSNPTGSSSTGSAYSNPNANLYAQYNPYSHLTASTRNPQSMQLTPTTTAATSSPGYRNDSLHAFFNSGLQYKIYQNSTALLPNSSSNTSSHQSAANLMAGLPSSSLVGALCSGASGLNPAERRKQRRIRTTFTSSQLRELERSFMESHYPDIYTREDIAMRIDLTEARVQVWFQNRRAKYRKQEKLRKIKDDPSIIQSLTPESKVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV30</accession>
    <name>A0A914XV30_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XV30"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11795.t1">
        <property type="protein sequence ID" value="PSU_v2.g11795.t1"/>
        <property type="gene ID" value="PSU_v2.g11795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF480">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11795.t1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28295" checksum="C538071B611DC0DD" modified="2023-02-22" version="1">MYYLYKFFDTTNISYKIFKFLISGVYVPTLSQKVVELIGSGNLNLNFKGFAVGNGILSNSRQVDSYVDLSYYRGIIGKQQFEYLKSCCPYPLEPAQICNYTATYLVFDYTTGLYGPKNSNDPVFMACANAITAIGQDNMWESELYADVYNFIQSCYTDSDGFKDGLKDYIKVEKLRSVLSKFTDSPIVSDGYSSFIDQGAKINTKSTDPFGGYRCYSSDAMINYLNTDEVKNAINIPTSSPAWNIKWTDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XW11</accession>
    <name>A0A914XW11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XW11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10710.t1">
        <property type="protein sequence ID" value="PSU_v2.g10710.t1"/>
        <property type="gene ID" value="PSU_v2.g10710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="31"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10710.t1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41815" checksum="06FB8FCFB1235103" modified="2023-02-22" version="1">MPKPIFKEFDTSSKQLNEWIQALNEFKLSKTIVLVIDNNKESHPIVKLAEALTGVQTQHLFFDTAFKVARGRPQTLENIVHKLNIKAGGINHLVDFGRNLKKINLAETLILALDVSHPTGDDYKGSTDEPSIGGLTGNYLPDPNEFAGLFFYQSPRQEAIDRTCLQIYVKKMLQEARKYRSIKNVILIRDAVSEGQYDMILEDELAAIDQSAKDLNIKAKLVGIIVTKDGNTRHFNVARGETSSMPPRSFVSFGSRYGFTQFFMTAHRSFAGTAKSVMITVIRDDLGLSTAELQFFLLGLTHMHQIVTAPVSIPAPLYQADVLAGRGQKVFRALKKYAERDIPKRDDGTIEYMQLSNLLNFNDANLPTTRYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY29</accession>
    <name>A0A914XY29_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY29"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10621.t1">
        <property type="protein sequence ID" value="PSU_v2.g10621.t1"/>
        <property type="gene ID" value="PSU_v2.g10621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10621.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23493" checksum="081756E7A9D4F0EB" modified="2023-02-22" version="1">MSLSTAYELVFESKEGADVTFIIDKKELQAHQFVLITRSPVLKAMIKGPMAPSNQRHSIDDPKVTYEDFNNFLKFIYTDQCEINAANAEVLLHLSHMYDVPFLFETCVNKIPQMFHESDLYKFAEIGFLYENKCDMIVKCMKAVPCNVPTARLQYFKRNKMVTTVSWISTGLALEFVKHCPRTDTFSENMVFQKSAGRCDIKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY33</accession>
    <name>A0A914XY33_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XY33"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11867.t1">
        <property type="protein sequence ID" value="PSU_v2.g11867.t1"/>
        <property type="gene ID" value="PSU_v2.g11867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF3">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11867.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25494" checksum="EA0AB07686712DA5" modified="2023-02-22" version="1">MIDIRSQILEIKNARGFNGLIPIVFVLNKTDLPKLKWQMTLEEIEEMVKAATNETSLDLCFITCSAANNENIDKVFSKIFTLGKLPKYMNPELHKMLRNELSADGVLTGRKKAMLQRMRSKFSRDNDDEILIDINARRPSLRTDLLLNRAKTAHLNRTPSLVGTSSSGGGAAGSGVARNGSLKNEGKTKKLSSNLTPSGISQQQQYHQHGNTMDANRLIRQVRNNCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XY39</accession>
    <name>A0A914XY39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XY39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11450.t1">
        <property type="protein sequence ID" value="PSU_v2.g11450.t1"/>
        <property type="gene ID" value="PSU_v2.g11450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11450.t1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25913" checksum="10375E275CB86D28" modified="2023-02-22" version="1">MSVEDTSVLASPTIDALQKLVRNSEFSSKAVRVTALLALDHPEAEKILLSILENREIEIDISSLSLCVNALSILILERADAQLFDHLYRAVSNHPDAASQLLPILCSNLVSSIRIGFHTRLVDALERACQTPKDFRILNDLKWQLCALSIIEKPRASWKALIHRIHTHRDTFLEGLLVTLAMQYPLPNFPITQWNSIERPLTLIDQNQIKDFLKSTVFITTPVFKNLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZS8</accession>
    <name>A0A914XZS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MARVEL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12032.t1">
        <property type="protein sequence ID" value="PSU_v2.g12032.t1"/>
        <property type="gene ID" value="PSU_v2.g12032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12032.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14087" checksum="312CB463654DE97E" modified="2023-02-22" version="1">MTSMNGHRFLTLPTSLKPAILILIILSMIFAGSSSPSGTNSFTWSWFFWFTIIVQLIFIIVVIALFALEMERLMTMGRDAWPIAEMAYSVIFGIFTVINIFVVSGWHSVAKNASLPVLAAVSYFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y098</accession>
    <name>A0A914Y098_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y098"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12888.t1">
        <property type="protein sequence ID" value="PSU_v2.g12888.t1"/>
        <property type="gene ID" value="PSU_v2.g12888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12888.t1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32921" checksum="8DCA46E470DF2386" modified="2023-02-22" version="1">MQEAVVDSAFYFVNSDEHVDYAMPITHKVVYMAGLGKIQAHPLEKKYTDIFDSAKKGVILFSFGSVVQSHKMPSEYKKAFLEAFSEFPEINFIWKYEKDEDQIANGYSNIFTGKWLPQNDILDHPKLLAFISHGGMNSVMEGSTKGVPMICIPVFADQKRNSQLLVRRGTAFKLDKSEISKESIVAAIKEIITNKKYRKNAQLLSKMVNAKPTTSAERVVKYAEFAAQFGDTGTLQTQGRFQSFWLLYSIDVIVFLFVVIAISITFCVFIFKKLFKIGKRFLQIKEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0J6</accession>
    <name>A0A914Y0J6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0J6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12985.t1">
        <property type="protein sequence ID" value="PSU_v2.g12985.t1"/>
        <property type="gene ID" value="PSU_v2.g12985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="67"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12985.t1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18672" checksum="B3D939357C0B1066" modified="2023-02-22" version="1">MNNFQDAVEIDDNETGSTISPPHPRYDLRPRTTKRSDVIPIHFNATLYRDAKPPSPTAVLRKYGIHTSSSYLLGSGHYSKVYKGYHSDREVAVKVIRLDQIGDDFKKRFLPREKECWAKLRHRNICELFLCLGCEQFNYLYMVMEYCQNGDLVSLFGKCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0K1</accession>
    <name>A0A914Y0K1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mucolipin extracytosolic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0K1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1299.t1">
        <property type="protein sequence ID" value="PSU_v2.g1299.t1"/>
        <property type="gene ID" value="PSU_v2.g1299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049134">
        <property type="entry name" value="MCLN_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21381">
        <property type="entry name" value="MCLN_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Mucolipin extracytosolic" evidence="2">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1299.t1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18120" checksum="80E112D8EED2954E" modified="2023-02-22" version="1">MNIRQFLHNRNITFKAEDALIISKATLNFNLRTIHFSTASTDQKPECYLIKIEITFDNSRHSGQVFVRLNTLISYVNLCNGKVLQVGPYTADSILISIIDIAVLICCLASLLLCSRALIKAYLLQTETQRHFSRILGIELEWNDRWEFLNLCCKNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0K2</accession>
    <name>A0A914Y0K2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0K2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12311.t1">
        <property type="protein sequence ID" value="PSU_v2.g12311.t1"/>
        <property type="gene ID" value="PSU_v2.g12311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12311.t1"/>
        </source>
    </evidence>
    <sequence length="418" mass="46578" checksum="C4E4FF0DD49F6FD9" modified="2023-02-22" version="1">MSKLTYIRCVIYCDGKEDEKFVKYTYPLAHNLTIREIKAAACSFLKIDGGVAKLHDSDFEELIIDDSERYMVDDGVWIEFNGLTATPYTFSAHDDPTTSQASAANDDPSAALIYGSNPTNEIAPATMTSANGFKTGPPAAANTESLSSTCSFEIDGTTFDFVSSDEYKTWTALNKDSVASLYKTLKPEVDICVKKISAYDFFDCDNFRGAVVVSLFPAACGQHLPICNQAQESLFKGVVQFIAKSYISEDLPYSELSAATKILHNWLKLDIILGWSSTNSDSRLGKVFRNRKYRSRKSDGTASPAAKKRKISFGVFDLQQLKKISNEIKASVDHLAMEEMYKNSCMLRCQWYEQLNADPNYKRGIAAEVIQKFPSLKTNLQLLHYDYTCFMTTKYGRAPDFGTVLANNADDILKAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y0P8</accession>
    <name>A0A914Y0P8_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein RO60 vWA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y0P8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13783.t1">
        <property type="protein sequence ID" value="PSU_v2.g13783.t1"/>
        <property type="gene ID" value="PSU_v2.g13783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056800">
        <property type="entry name" value="vWA_Ro60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="60 KDA RIBONUCLEOPROTEIN SSA/RO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN RO60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25045">
        <property type="entry name" value="vWA_Ro60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-binding protein RO60 vWA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13783.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15712" checksum="2EEB1557D044B512" modified="2023-02-22" version="1">MVAMKTEPIAETMCFHTDGFVPLDINKDQPLTKILETIDSLPFGGTDCAQPMLWALENKKKFDVFIVYTDSETWYGDIHPFEAMKKYRKEMDIPDAKLIVMGMAANEFTIADPSDPNMLDVVGFDSGVPEVIRGFVLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1X4</accession>
    <name>A0A914Y1X4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">General transcription and DNA repair factor IIH helicase/translocase subunit XPB</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA 3'-5' helicase/translocase XPB</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y1X4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11811.t1">
        <property type="protein sequence ID" value="PSU_v2.g11811.t1"/>
        <property type="gene ID" value="PSU_v2.g11811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="307"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="525"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="724"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11811.t1"/>
        </source>
    </evidence>
    <sequence length="761" mass="87518" checksum="1568497E36C1FB30" modified="2023-02-22" version="1">MASVEQILLKIGSQRADQFNTRGNDNSMSYMRKIYGDRDFSYMKLKPDHRSRPIWISPDAHIYLEAHSPVYKHARDFLIAIAEPLCRPEFIHEYQITAYSLYAAVSIGLVTNDIIEYLERLSKTTLPDGIKEFIKLCTLSYGKVKLVLKQNRYFIECRHSEIVQKLLNDSVIQAALVDENTKATIENHADQMANMTTTLLNTAPEQTVTTEPPVDEEVPKDIADFYTNVIDNHDEDDDADALRNLQILSFEIKQEHLENVQKKCIELEYPLLAEYDFRNDEFNPNIKMDLKPTTGLRPYQEKSLRKMFGNSRARSGIIVLPCGAGKTLVGVTAATTINKRCLVLATSNVSVEQWRSQFRLWSTIQDHQIIRFTRETRDQVPTKPDPVVCISTYSMVAYTGKRTYIAEEAMRYISSHEWGLLLLDEVHTIPAKMFRRVLTIVQSHCKLGLTATLVREDDKITDLNFLIGPKLYEANWMELQADGHIAKVQCAEVWCAMTGEFFAYYLTSNISRRLLLAVMNPNKMRTCQFLVEYHKARGDKIIIFSDNVCALKRYAMEMKIPFLYGETSQSERMSILQNFQYNPKVSTILVSKVADTSFDLPEANVLIQVSSHGASRRQEAQRLGRILRAKKNTNDEFNAYFYSLVSSDTIEMTYSRKRQRFLINQGYAYKIVHNIPEMEKANLCLPDDKSRSDLLKSLLSLSDADADQDDVKDEDDITQNRVNRRDGTMNALSGGNQLTYTTTSRRNEEDRHALFRKFRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1Z3</accession>
    <name>A0A914Y1Z3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y1Z3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13478.t1">
        <property type="protein sequence ID" value="PSU_v2.g13478.t1"/>
        <property type="gene ID" value="PSU_v2.g13478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13478.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19124" checksum="0F0E530A2033A258" modified="2023-02-22" version="1">MDTPRKLPPFPSGTSTRNRRQIEVEPQPLYDEFIEILNVALSDASQAGVMMQEIAHRELHPPPATTPLRNHRKSNNQRFTPYSIERRPSNRFANPNPPPSMFDIRNTLFSPPVTPQRPALQFFSPLTLSRSADSLTPSTTPQRPSPLSNPATVSRVFNLPDFQNLHVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y1Z4</accession>
    <name>A0A914Y1Z4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y1Z4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14204.t1">
        <property type="protein sequence ID" value="PSU_v2.g14204.t1"/>
        <property type="gene ID" value="PSU_v2.g14204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000336">
        <property type="entry name" value="Aldehyde reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14204.t1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46115" checksum="3E0818FC42CED352" modified="2023-02-22" version="1">MAPPLSKHSIVSATSSTSSSTLSSGNSSFISDEPIVLVTGASGYVALHCVDQLLKAGYRTRGTVRSLRNAEKIEPLRRLPNQHLLELVEADLERPEEWPSIVDGCTYILHVASPWPIVADEKTITIAVNGTMTVLRAASKCSSVKKVILTSSCAAINDGHKNNERIFDETCWTKLDSKKVENYAKSKTIAEKTAWDYWNSLNPMTKFELTVLCPTFITGPVLSTVEHGSATIIGRMMDFRTFLAAPKACLGVVDVRDVAKAHILAMTNEKTNGERILITHTQPTWFRDMRDWLMEEFKDDGYLFSPITVPNWLLKIYAKTNIDPQSSAVVHRIGPELRFSNQKSIDLLRMKYISPKQSVIEMMHSMIDFGMVRKPPLGKSKKTSSKNKNNNTNCADSEFSATSTSQTTHSRTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y268</accession>
    <name>A0A914Y268_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y268"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13550.t1">
        <property type="protein sequence ID" value="PSU_v2.g13550.t1"/>
        <property type="gene ID" value="PSU_v2.g13550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13550.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17555" checksum="96477C0C1DEC62AA" modified="2023-02-22" version="1">MGISQFTMAFSFIGLAFIPSGYIHFALTLYVLAIIGSACNSVGYYKSLSFSCGVYTAKVMTWISFLNAIVLFSLPIFKTIIASDDREEDWRILFLSAAIIGIIAVIVYICTVRVDLRPWAQQLLKSRRPSISTICSISPPDLKTKKNSLNSLGSIVINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2E8</accession>
    <name>A0A914Y2E8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2E8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11971.t1">
        <property type="protein sequence ID" value="PSU_v2.g11971.t1"/>
        <property type="gene ID" value="PSU_v2.g11971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11971.t1"/>
        </source>
    </evidence>
    <sequence length="519" mass="58608" checksum="FB8569687E026FB7" modified="2023-02-22" version="1">MCNDDLCKAGEDYCGFINGNGNVLNGVLVGLESGDVIPCGPFTPRSFVNSILGCFSCTKMKAIILKVFELDSFQYSNSIAFCNEIKAKFCEANPNISCYFISFDHYWLSSMLIAANLTLNVGEFLLMGITSHKNVNVFELKFTETGYMITDKRIINIDCNNGDEEVRDAILGIIDPKKIIIMILSAKNPTMVLLKNVLKSSKLMVLEQNRVENDGRFCQEITKWILNKKKTKYYVLPTCSRKYIVTDTVDGSGTPLLVADTHEALPLNKSCVIPRTTMNLSMSYIDVITGKPKVVSVKKFGRKCHQYNVTLTIKSKNSPLCQAESVILPTIESFPRHIAAIDQDKIPVIGFFDQTSFLCLWNDENKVYEFCPSWNGLYGNDLFLHFNQEKPSFGQKAFELFQAKPDSAVYDVIQIMSMSPSAFKANPKWSFKIIQNEEHPILLDFASFDGNRRAASPSFLMAMMIKEHIKVIKNETGSKPKILGVCVLNEFNKEEKDRIEQQIQESCRLLSIDCHFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3N3</accession>
    <name>A0A914Y3N3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3N3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13839.t1">
        <property type="protein sequence ID" value="PSU_v2.g13839.t1"/>
        <property type="gene ID" value="PSU_v2.g13839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13839.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24190" checksum="3A484516A8B47737" modified="2023-02-22" version="1">MSYSTLSPEMTIEAIPIISYDESDVSIASETVNSGSRQYAGGEVTAIQNGDEIVETNPSMLNAMVNGLPTENASEIYRAYLNANDLTENEHLFLPKENDANYMSKENIVQWIKEGEKATTTSAPQQAEWEVTSMNSYSNLESILSTSEKVDYGIREINHDGCRDDETLKDVISLASVDESDSIASSDFSDVPIIHTPHPSGSRGGNIEEAMKRRTPKTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3P7</accession>
    <name>A0A914Y3P7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y3P7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14816.t1">
        <property type="protein sequence ID" value="PSU_v2.g14816.t1"/>
        <property type="gene ID" value="PSU_v2.g14816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14816.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12023" checksum="A20E39A14D1DABAD" modified="2023-02-22" version="1">MLTLLPLQYYYYSELIDEGDENSSPVVGYDSTPRKKLVPMKKPLMDITQQSVDKHLEEIFVEPLFFANPQPEEEIVQLNEELVKNQMEVADYKKAEEIAKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y449</accession>
    <name>A0A914Y449_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LRAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y449"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14214.t1">
        <property type="protein sequence ID" value="PSU_v2.g14214.t1"/>
        <property type="gene ID" value="PSU_v2.g14214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="11"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14214.t1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27458" checksum="2A9F22C9FAF6CE3A" modified="2023-02-22" version="1">MPPLMRRRGDLIEHKKVGYSRWSVYIGNGEIVEVDSDNNHEVIRRPRKFEVSVSWVNNEFDERVKPLKNDVIVQRALSQVGANWKDTHPLAIINNISEHFAKWCRYGTDVCNQSPHLSFHDNHASVGLGKVETGLLSLKLPNAYTTAQNNSNSTNFKVGAELIGGEAFGAVKWSAQAAADAGIDHGNGKHAINIGVDGPQAQVGPLECKSGIRADTGVNCNKDGLGFTLLGTGVQVGRKTKVSFLGSSIGFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4K3</accession>
    <name>A0A914Y4K3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4K3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14371.t1">
        <property type="protein sequence ID" value="PSU_v2.g14371.t1"/>
        <property type="gene ID" value="PSU_v2.g14371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14371.t1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21747" checksum="4C452320CFF3DC4D" modified="2023-02-22" version="1">MPLYLVFIDFKKAFDSIELQSIWDALEKYGIDAGDIEIIKLIYANASSSINVGSSSANINVQKGVRQGDTLSPILFILTLQLALDRVNWERGIHIGESLLAHLDFADDLVLCSRTLEGLQSLLDQVSTHARDVGLHINVQKTKWMSNISNDEIILLNNQEDKLFTGHPNPKDSKKKLQEEYVLVGMRLTKPNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5D2</accession>
    <name>A0A914Y5D2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription and DNA repair factor IIH helicase subunit XPD</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CXPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">DNA 5'-3' helicase XPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">DNA excision repair protein ERCC-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">DNA repair protein complementing XP-D cells</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Xeroderma pigmentosum group D-complementing protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y5D2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1290.t1">
        <property type="protein sequence ID" value="PSU_v2.g1290.t1"/>
        <property type="gene ID" value="PSU_v2.g1290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035315">
        <property type="term" value="P:hair cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="7"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="255"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1290.t1"/>
        </source>
    </evidence>
    <sequence length="763" mass="87135" checksum="3E77E357385D6EDD" modified="2023-02-22" version="1">MKLQLDKLTVLFPYEHIYPEQYYYMAEVKKALDASGHGVIEMPCGTGKTACLLSVIVAFMLKFPSRIQKLIYCSRTIPEIEKCVEELRHLFNYYERVGGGAPEFLAIALSSRKNLCINDAVVSKREGIAVDGACQSLTSSIARARKKIDPDYPQCDFFETWDAKRDYPIPNGIFNLSDLRAFGQKKKVCPYFLSRSAVNKAHIVVYSYHYLLDPKIAEIVSKDLNPRSVVVFDEAHNIDNVCIESMSVSLSRRLITRCEGNLESLDRHLKKLKNENSERLKEEYDRLVENLREKQREREEDVAIVNPGVPDEVLQEAIPGTIRTAEHFLRFMTRFSEYIKHRMRTRVVHVESPASFLRDIHSSLMMERKALKFCSERFASLAKTLELADVSNFNPLVKLTQFATLVSTFSHGFSVIIEPDEMSRDENSLPDCLVHLSCLDASVAMRPVVSRFQSVIITSGTLSPLDMYPRILDFQPAVMASLSMTQSRESFVPLMIGKGNDQVEISSKFECRDDTAVIRNYGNLLQELSKCVPDGIVVFFPSYIYMESLVSAWAKTRLLDDLTKHKLIFMETTDAVETAHALEQYVRACESGRGAFLFSVARGKVSEGIDFAHHLGRAIVMLGIPFVYTEGRILRARLEYLRDQFDIRENDFLTFDAMRHAAQCVGRAIRGKTDYGVLVFADRRFGKIDKRTKLPRWIQEHILPGCHNMSVEEGVSKIRRWFPYMGQPMKKEDQLGVSLVSEEMIQENPQVMDKYKNVVVEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5H7</accession>
    <name>A0A914Y5H7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RFX1-4/6/8-like BCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5H7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14496.t1">
        <property type="protein sequence ID" value="PSU_v2.g14496.t1"/>
        <property type="gene ID" value="PSU_v2.g14496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF33">
        <property type="entry name" value="RFX, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX1-4/6/8-like BCD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14496.t1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24681" checksum="70C20BB3D5CC91DE" modified="2023-02-22" version="1">MLHLIEQQRFKSVENLWINFWSGNRSGSLTQEQMFNLVTLPEIYNTIDKMDQLFYQAAVDLLMPNVFAPLSNMKYLTAIRNFVKQIVPTYKKALEKAPAEFLKIKVTAGKAFAHRMKRYTAIHHLSDAARAVLSHPKQVETMYNEFCQIDVASIQEQAGWVCECDPLLFNSIFNAFKENLKAARELEAWAEWMEAIVDQVLAKYHDQPLHVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y637</accession>
    <name>A0A914Y637_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y637"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13124.t1">
        <property type="protein sequence ID" value="PSU_v2.g13124.t1"/>
        <property type="gene ID" value="PSU_v2.g13124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021900">
        <property type="entry name" value="DUF3512"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12024">
        <property type="entry name" value="DUF3512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="101"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13124.t1"/>
        </source>
    </evidence>
    <sequence length="543" mass="62153" checksum="73069671B915B9E6" modified="2023-02-22" version="1">MRRDKDRERKDKKKKDPKSETVGDDAAEPVEEDETTEQDQEMEVTEGIESETEEDRPQPTSNMTAIKNVMPDVYLRGYSSFQLFCDYILRKLILKDPEEFFAYPVSTHVAPDYHQIITSPMNFLTIRQKLSANDYTKLEELKFDVILICENAMLYNNPHTIYHVAAQKLLAVTKYYFSEDYLEYLRYTLPFGKDLERQILGLPEKDLPQRTQRVPTEPRPAFQKQQMESITAKKLLADAPAALRKKLTTEVPKWPLGYIDNHDGAVALNLVTSTEAAKIPLGDLIGKIEAGHTGLLQNFEEAFPALTPSSYLNYEPFASFAPMYDTTWATMNQRDSELLAQTYGDRENAADIFQLRQMVVDSGGYFLELFDNMLNTLTDGEHSRTVETLQTSEKDVLEAVEKNIERPTTPTSFQKLLDDIATLENIGVDTSFVEEIKAEYGLLDMGISAMIPEEEIERNGYMLQDLTYLQNQRLNRTVTNLADIPQISDAEIELSSRIATNFQQQIVQFNVCPNEMVSNHTIHNAIGINEDVDYDILREFMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y6N1</accession>
    <name>A0A914Y6N1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THAP4-like heme-binding beta-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y6N1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15856.t1">
        <property type="protein sequence ID" value="PSU_v2.g15856.t1"/>
        <property type="gene ID" value="PSU_v2.g15856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037977540" evidence="1">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15856.t1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23575" checksum="6CB238FA23EC7904" modified="2023-02-22" version="1">MYKKLFALIFLGIFCVFTNGRYEDRYDMNTLPWDLRPVRDFIGMWQLDGPVRGHWRDLPAPDLIDFSINPLPKFGARTVNITHTYYDAEKKNVIRSDYGFMPVKNATRRDPRVHLAYLTTSSEGYSMMEQGFVKGPKIVCHLKQFLRRSFDVGSKGVDLDIREFERQYEQTDFTHMIMRIRAETSVETEAYTANYKKILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y818</accession>
    <name>A0A914Y818_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Obg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y818"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1542.t1">
        <property type="protein sequence ID" value="PSU_v2.g1542.t1"/>
        <property type="gene ID" value="PSU_v2.g1542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="1">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1542.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15296" checksum="FA820AAD9F01D244" modified="2023-02-22" version="1">MLQPRLSLSNFLFCNHFSRLSASTSATIHQGGGEFTKKPIFPTKKTADGEAARFVDFRKINCVAGNGGNGMVSFLRQYKAPFGGPDGGNGGHGAHVIFQADSQIKDLSHLPTTAKEKMEFLEHPNVAMVKMLIIFISKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8M5</accession>
    <name>A0A914Y8M5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y8M5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15107.t1">
        <property type="protein sequence ID" value="PSU_v2.g15107.t1"/>
        <property type="gene ID" value="PSU_v2.g15107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15107.t1"/>
        </source>
    </evidence>
    <sequence length="165" mass="17664" checksum="4D659864F0A091F6" modified="2023-02-22" version="1">MSGSSNTTPSGKHSKRFVNPETGDILDIPAGYQPAAPEPIAQEAHPTAPVTNGTSVAADPPSTPDAPQPQSTTVTPPPVPVQSPSPRPAEVPRPPSEAPVSSILATFQQQPIEDWRNLELPTESNTSPVMLLKMALLANYTLPQWNQLKTFMVMKNMKPAAQIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y925</accession>
    <name>A0A914Y925_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y925"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16694.t1">
        <property type="protein sequence ID" value="PSU_v2.g16694.t1"/>
        <property type="gene ID" value="PSU_v2.g16694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16694.t1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23071" checksum="D65C384BC6CD960A" modified="2023-02-22" version="1">MRTKQRPNSGKPELVFVFRDGLSEGQILMAKLEELEAIKEGFQEYYGHQAEKLPPFVMVLATKRHNRRFYSSNHENVLPGTVVSQGIARLGATEFYMQSAFPIQGTAKLTDYEVIENEAKLSVNDIQAFTHGMCYTHQIVSSAVSLPEPVYLAHELAKRGRNNLICYSDVSVVPRNADGIDYLKLNQKFTYLDNDLIHRRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9G5</accession>
    <name>A0A914Y9G5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9G5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15924.t1">
        <property type="protein sequence ID" value="PSU_v2.g15924.t1"/>
        <property type="gene ID" value="PSU_v2.g15924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038100099" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15924.t1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22365" checksum="D3F1D7A914B455BD" modified="2023-02-22" version="1">MWKNFVLIVLEMAYFESVTSCAGGIGGNGVLINPSISMKFHPPTAWTYPETTAATDLSYFPGQPLTQNEAQLRANGDIESAVLAGLQTLQIPTTGVTVTPQYSPPLVSDCKKLTVATTGQFGFEEGGAITKLITPPGPAGITAIFCSQRNFAGTPPSLVFTMVDFIQQASVKIDGITLSEYQATLLAAKVSQYLMLNSRVDFTEEVMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB23</accession>
    <name>A0A914YB23_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YB23"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16489.t1">
        <property type="protein sequence ID" value="PSU_v2.g16489.t1"/>
        <property type="gene ID" value="PSU_v2.g16489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF102">
        <property type="entry name" value="4-HYDROXYPHENYLACETATE CATABOLISM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16489.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12121" checksum="0A5BF81ECE67670A" modified="2023-02-22" version="1">MGRDLGLSATMFGLATTLFYAAYVIFGIPSNIMLSIVGARRWIATIMVLWGIASTATMFATGPTSLYVLRILVGITEAGFLPGILLYLTFWFPAYFRARANALLWWQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YB39</accession>
    <name>A0A914YB39_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YB39"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15978.t1">
        <property type="protein sequence ID" value="PSU_v2.g15978.t1"/>
        <property type="gene ID" value="PSU_v2.g15978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="116"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15978.t1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23909" checksum="04C7A9998BB14478" modified="2023-02-22" version="1">MKEICEELDLEVDFIRRGRRPTLPFKLYLKEKYFDAYIKSILEELKLRFGNRQQAAFSLQSLLPSHASKLSFEKIEKAVRQYSSFLENEEIEDEVQTWKLYCSSLEKKPDTVTETLTLFDKTLSLLYPNIYTLLIILATVPVSTCTVERSFSLLRHILTDFRANMLPERTSNLAILAWHNYLANALDGNKIVDIFNEKTRRVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBG6</accession>
    <name>A0A914YBG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBG6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14835.t1">
        <property type="protein sequence ID" value="PSU_v2.g14835.t1"/>
        <property type="gene ID" value="PSU_v2.g14835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14835.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18558" checksum="1EB0EEC8BE09156B" modified="2023-02-22" version="1">MDLIRKGFIFPSFDALSDILCEASSKAAGKRIRFTDNNGHRAYADICDPKIITAISALAENKTSELIRGLANDYCQLNARGSLCDSTSDKTKPKFCLIRDSSGYITMKKYPSLASNSACDCCRRQSYSQHGQCYNEDKLIQKTDMIGQVFPTNSKFDLHLCKIEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBI6</accession>
    <name>A0A914YBI6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBI6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14854.t1">
        <property type="protein sequence ID" value="PSU_v2.g14854.t1"/>
        <property type="gene ID" value="PSU_v2.g14854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21341">
        <property type="entry name" value="TTC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028796">
        <property type="entry name" value="BBS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14854.t1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22466" checksum="6AD3642CD5337546" modified="2023-02-22" version="1">MIAAWSLKLACFTEEVYVDELENDEAGLADTYMDDNAIATAARPGTSFNRPITSGKGPSPAVRPRSSTGRPISGMARPETRLKTGTMEQALRTSRTSRTARAVSSSTARQVRLGTASMIAQQDGPFVNLGRLNVDKYATDPQINRYLFEYIFMHEGDMRLAHQIAAAATKKSEYKDWYWKNALGKCYYRYGITVAIHLLIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBM0</accession>
    <name>A0A914YBM0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YBM0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16679.t1">
        <property type="protein sequence ID" value="PSU_v2.g16679.t1"/>
        <property type="gene ID" value="PSU_v2.g16679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004394">
        <property type="term" value="F:heparan sulfate 2-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF17">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16679.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17113" checksum="3EB47CEBAFD29F1E" modified="2023-02-22" version="1">MDIFGLPNPIYINLIREPLERLLSHYYFLRYGDNYRVGLKRSKAGHNETFDECIEMGGKDCDMKQMWIQIPYFCGTAAFCSEPGNEMALKQAKWNLVNRYLVVGLNERMEDLIAVLEKLLPNFFKGAFGHFKSLSGSFYKCFFPAGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YBZ2</accession>
    <name>A0A914YBZ2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YBZ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16806.t1">
        <property type="protein sequence ID" value="PSU_v2.g16806.t1"/>
        <property type="gene ID" value="PSU_v2.g16806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037870501" evidence="1">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="179"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16806.t1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33606" checksum="88936DC1C9954597" modified="2023-02-22" version="1">MLTFLFLFLFLFLLIQYSAADCPENSIEWHSHCYSFFNISTGFADAELKCNQNGSHLVSIHDGFTNALLSQEAAKNFCKSTETDFWIGATTLIALKTWNWTDGTTFDFTEWNKGEPKNISGSNCAALSTVDGYWTSQDCFKSKPFVCETANFLTTPLPRTTPSYPLNGNCSMGWFYIPQAHACYGANGGEHAFTWTAAQNYCESIGAQLPAIHSSAEVQYLDSLISAFWRNLWTGIVSVDGGKVWKNADGTPADFLKYGSWCEGHPFKNVTGERCVARFRPCYIDFDCITTIFDATCKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YD84</accession>
    <name>A0A914YD84_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase FkbM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YD84"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1740.t1">
        <property type="protein sequence ID" value="PSU_v2.g1740.t1"/>
        <property type="gene ID" value="PSU_v2.g1740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989:SF3">
        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22989">
        <property type="entry name" value="UNCHARACTERIZED DUF13 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1740.t1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16270" checksum="C0A64AF79AE13085" modified="2023-02-22" version="1">MVLGTRKQRTLFLTVRTNTTYHEKKVKVYALSDLLDKFVKSRLVQYMTIDIEGFEYGILEALLRSKKLYNEGVTFCQIDAELHSNRTKIQNILHKFDAKDSPYLPIHSKKFNIHEKVTWLNIEREECRQAFDINQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YF49</accession>
    <name>A0A914YF49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YF49"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18075.t1">
        <property type="protein sequence ID" value="PSU_v2.g18075.t1"/>
        <property type="gene ID" value="PSU_v2.g18075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18075.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8160" checksum="0860A8097BA44B0C" modified="2023-02-22" version="1">MMHAEKRSLNISRETERLKEELIQLKEDSEANHEKSNEPQMEEDDTSAAMDFERSAETFMVVDDNEKTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFP6</accession>
    <name>A0A914YFP6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNase II family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YFP6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18276.t1">
        <property type="protein sequence ID" value="PSU_v2.g18276.t1"/>
        <property type="gene ID" value="PSU_v2.g18276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004531">
        <property type="term" value="F:deoxyribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004947">
        <property type="entry name" value="DNase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858:SF24">
        <property type="entry name" value="CELL DEATH-RELATED NUCLEASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858">
        <property type="entry name" value="DEOXYRIBONUCLEASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03265">
        <property type="entry name" value="DNase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18276.t1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16310" checksum="B72AEA67A323DDBB" modified="2023-02-22" version="1">MHFAKSGLFGKDLYYDFVAPTLATGLLVQSWMHKSNGSYANNLNSTCRPPYSFNVYDAHKIQTPFLNFTSYDDHSKYAIAHVESGLPYPYLCIGDINRQITQTKRGGGTMCFLDGSVFPVFSQLIETFYPCKSFKYNHYDIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFZ7</accession>
    <name>A0A914YFZ7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFZ7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16269.t1">
        <property type="protein sequence ID" value="PSU_v2.g16269.t1"/>
        <property type="gene ID" value="PSU_v2.g16269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043225">
        <property type="entry name" value="BACK_BTBD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26017">
        <property type="entry name" value="BACK_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="409"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16269.t1"/>
        </source>
    </evidence>
    <sequence length="706" mass="79253" checksum="49DD77796C9B83E2" modified="2023-02-22" version="1">MRNSSMLWEQYSLQRDKLIINLRTKLLTNMSSLIGHAETSDLLLVAADGKKLPAHICILRQRAPIFFEKHISPTLDARTPRQRRIGEPLEVAIGDVDSAGLSFFIKSVYTDEEIQNLENENTIKDSTSDQKRDDENPDSSNFDIDHEFDDSQHYANEEEEEEGGREGETPRQDCDSLDRTPGAYQKELDKSEEIIYSVPIPREHDSGFHQPSSIEKPPPSTTATTTTSIITISEEPIMTSFRELANDSPMCLSGYSERSQYDIVEEEAEHEISEEASQNSSHFGSHGRFYHLEDSGIVSSQIESPKKKKSTTKIFPMFIGFGSGDSEMTQSMPSSTLSSSPYSSTNTLSAGSIRGRAMLARRLSVTSLTSLTSIDLTPTTENVTPIGDKLPCSTLGGDLLEMYQKSLDTDTIIVTDGGDLHAHKCILWATCPTFRKILKSSTKIELRGFSRNAIDFLLSFLYGGLTNIPEEVEVWEVIALATHLNLEELAQVAALHLKAHKCHFFHRPCATCVSAVFDALPQFRTIKCLNGLYDEAMSWQARHFSRIWKGRVFLHLDEQWQHGCRDALINEIDEELLIDTLLGCEKLQASLSRTKSQQLAESVLSLVNDVIEYCTEFLISSFDLILGSTAFKNHGKGLALNLALLEDLFPPLIHSLSADTAIRAFITLRDLLIEIQQNEEDLQLQQSPNRRRSFLHIPIHDWNPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YGI4</accession>
    <name>A0A914YGI4_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YGI4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16449.t1">
        <property type="protein sequence ID" value="PSU_v2.g16449.t1"/>
        <property type="gene ID" value="PSU_v2.g16449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16449.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="32440" checksum="93585D4CD9C20743" modified="2023-02-22" version="1">MTITYNLDVAHFGFKGFLSILFRWRGSVWKAVALPLLYWLIAYYSFFCCYYFLFRPYDKYIFDKVMDKLRGNLNTFIPMTFILGFFVSSVLRRWQDWLTNMGWIENTATVIATYINGTDEITRAMRRNIIRYLVLSQTLVLRNISVEVRRRFPTLETVEAANFMSSEERKLLEKSTDDVYTQFWIPTIWAEKIVCDARKNEKIQSEPIAAHIARKIDDFRKQLRNLLIYDWVPIPLVYPQLVTFCVRLYFVLCLFTRQFFKSDDIGLPVSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YH92</accession>
    <name>A0A914YH92_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coatomer subunit gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YH92"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18157.t1">
        <property type="protein sequence ID" value="PSU_v2.g18157.t1"/>
        <property type="gene ID" value="PSU_v2.g18157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000011">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="1">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="2">
        <location>
            <begin position="66"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18157.t1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19882" checksum="C7DF1C9710164C7E" modified="2023-02-22" version="1">MIPLPQLPYSQLGTTYAILKDESLTATFGATLKFKVVDVDPTTGEPESDEFYDDSYVLEEVEIQLGDHIQGLIKANFSSAWETAGEENEVEETYSLSTYDGLQDAVQGLLKFLSMSPCEHSEKVAEGKSSHTLLLSGKFRSGQDVVAKVRLALDPSDNSVTMNIIVRGEDKDISEVIANAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHX1</accession>
    <name>A0A914YHX1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19926.t1">
        <property type="protein sequence ID" value="PSU_v2.g19926.t1"/>
        <property type="gene ID" value="PSU_v2.g19926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19926.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11703" checksum="58C8C300AD4BC48B" modified="2023-02-22" version="1">MFARFFSIIFGSLVGTVIILSVIYEYGLEVEDAIRYTLIVLGGVSALSLIITVCFTCFVKSFGYDEEPKKHTNSFFYHGNGINPVYILSFNDNDKMQQVSFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YHZ4</accession>
    <name>A0A914YHZ4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YHZ4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1842.t1">
        <property type="protein sequence ID" value="PSU_v2.g1842.t1"/>
        <property type="gene ID" value="PSU_v2.g1842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1842.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32402" checksum="FE64523C5866CE0F" modified="2023-02-22" version="1">MVTERNMTQQNVPLTDRQAKLDDLKRILQGNAGNQDILEEGELESDDDETCKKRGSVTPDENVTKKLTKSSNTVFQTVQPCTSVAITDHIMNYNVPMKQESTKRKAESCSKNDDDVKKSKIDGTNYSDLSSSVSPSSESTSTPPYQFVSSLWGDYKIPKKGSPAASSEIKPRQKPSPQRSSLAPALSNSSLLEKRYDDYISSSLPKSKPYYSPQTASTSSIKSQAKAIKLSSSRGYSESPRPISGGKTIRMTPLRPQQRCTSFKTQSPVNGFPRCELLTDNGIKMIIRFPKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJL5</accession>
    <name>A0A914YJL5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA hydrolase/transferase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJL5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19711.t1">
        <property type="protein sequence ID" value="PSU_v2.g19711.t1"/>
        <property type="gene ID" value="PSU_v2.g19711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432:SF20">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432">
        <property type="entry name" value="ACETYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19711.t1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14510" checksum="FFED53F037CA1CC8" modified="2023-02-22" version="1">MPNFVNSADYTPIFLQDTIRIFDDKVIPVDVALVTVSKPDNHGYVSLGVNVDCTSAAVRNAKKIIAVQNDSQPFTFGDGLIHISQIDAICQTDNPISALPKSVPTPEEMAISKLIAQNLVDDYATLQLGIIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKL8</accession>
    <name>A0A914YKL8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKL8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20885.t1">
        <property type="protein sequence ID" value="PSU_v2.g20885.t1"/>
        <property type="gene ID" value="PSU_v2.g20885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037962193" evidence="1">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20885.t1"/>
        </source>
    </evidence>
    <sequence length="109" mass="11421" checksum="38AAE2BA7A7424A4" modified="2023-02-22" version="1">MGFRGPFNCCELFVVVVVVGPLSSEEFGETLPSGGGDTVPFGNIVAVEGPNDVDCCCCCCCCCCEEDGPTGGRVEPTRLFIGSGEGTTFRRRGAGDLPCKAKLTIYILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKV3</accession>
    <name>A0A914YKV3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKV3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17957.t1">
        <property type="protein sequence ID" value="PSU_v2.g17957.t1"/>
        <property type="gene ID" value="PSU_v2.g17957"/>
    </dbReference>
    <dbReference type="WBParaSite" id="PSU_v2.g9898.t1">
        <property type="protein sequence ID" value="PSU_v2.g9898.t1"/>
        <property type="gene ID" value="PSU_v2.g9898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17957.t1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9898.t1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11272" checksum="7890CF0F8732B1B1" modified="2023-02-22" version="1">MNDIHANIHALERETKFVVAEINDINAEIQKIEKAMTAHVESGQCQLFNGKEYGATITDEVHQTSSPDSPEIIFIEKSQKPTAQMKTADESWRPNECWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKY8</accession>
    <name>A0A914YKY8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKY8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21011.t1">
        <property type="protein sequence ID" value="PSU_v2.g21011.t1"/>
        <property type="gene ID" value="PSU_v2.g21011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21011.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15529" checksum="A606DBF55AC64DBA" modified="2023-02-22" version="1">MGQPRATEAAVQKDIKSLFSQYEKDKPFDWQVKRQRVLGKKVIYDYRVRPEKIVTTDWVYTHSGQEYSSEDQIRSVILATRVSDPQCPATSLTEDPWVELLGLGRGDDGSHSRMLVDSGAGACAPGQNGALSESTVPDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLS8</accession>
    <name>A0A914YLS8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLS8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19869.t1">
        <property type="protein sequence ID" value="PSU_v2.g19869.t1"/>
        <property type="gene ID" value="PSU_v2.g19869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19869.t1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13988" checksum="9F0DF25DD537221D" modified="2023-02-22" version="1">MLYNILLIRFDTQQRIAFFSNQKNKEYIQMYVDGNIKAEHREAVVKAAETFFSFIPEFINTENLGANRPFIELEENLGDLPISLSAASLSEFPRPDVVMRSIDATSFSLVIPKICKCFTTNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMG7</accession>
    <name>A0A914YMG7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMG7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2012.t1">
        <property type="protein sequence ID" value="PSU_v2.g2012.t1"/>
        <property type="gene ID" value="PSU_v2.g2012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2012.t1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21237" checksum="B6E95D9303C88C83" modified="2023-02-22" version="1">MESEWETMKNFGDLWNVGYEDFTIVADKKQIKVHKCVLAYHSPVFDASFQSLLKESVKNKLEITNYSYEVVEKAVKLCYHRDLVSDISVEDAFSLFNFAELYNMTEIQDNLEGYLCDKITVTNVCEILNFSVAAKAVDLKNRCMDFLMICFAKNEFVPNMELLEKEYFISVYTNSACRKSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMQ2</accession>
    <name>A0A914YMQ2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A914YMQ2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2178.t1">
        <property type="protein sequence ID" value="PSU_v2.g2178.t1"/>
        <property type="gene ID" value="PSU_v2.g2178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="25"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2178.t1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32658" checksum="6ECC0845443719E3" modified="2023-02-22" version="1">MWKPKFMIPEEISSSNFKDFGEGIPCLLGIDEAGRGPVLGPLVYGCAVSALDQREKLVELGVDDSKALTEKRREEIFKLMDKDPDTQDFVAFAVQVMSPRLISASMYRRIKTNLNEISHTCAIALIQLALDSGINVTEVYVDTVGPKGTYQAMLQRRFPSLAITVKEKADSEFPIVSAASIAAKVIRDRRIESWKFTEKEMILPKDGIGSGYPGDPSTKKFISDCIHPVFGYPSITRFSWKTAEFALEKGALEVRWEDDIPPEKQIKSYFDGKPKNEAAALLAEWNLKAVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMY6</accession>
    <name>A0A914YMY6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMY6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20758.t1">
        <property type="protein sequence ID" value="PSU_v2.g20758.t1"/>
        <property type="gene ID" value="PSU_v2.g20758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="32"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="192"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20758.t1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42757" checksum="0550971193A6BEA3" modified="2023-02-22" version="1">MEPNVVHTEAIDPSSANVFAANSSQTEIKVEFLKHNWTVKNFSHCYQEYLENYVHLPRGEDTLTWSIKIYPKGNGENNKDFVFLCLNRVLNQSIKAHKVGFRSRFYLKNFENKEIECRIHPNPSHSDYVSYIKRDVLFPQIQPHDSITVFVEIDVAVETITTNVGELLPPLANSEKILSSNMLTLLEEEKHSDFAIRAGKMEFKVHKAILAARSPVFSAMLDHENTEESRTGIMNITDVDGPVIKEMLKYLYSGYYSEDLDLAEDLLIAADKYRLDELKQNCERTLMKGIKFDNACHMCIIGDIYCAKSLKDSAVRFIQRHPCDITQTEGWQAILREHNALVTDIVRSFDKSLPSIIGPDKPAVPTTSSTPSAPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YP85</accession>
    <name>A0A914YP85_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TonB-dependent receptor-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="WBParaSite" id="PSU_v2.g21446.t1">
        <property type="protein sequence ID" value="PSU_v2.g21446.t1"/>
        <property type="gene ID" value="PSU_v2.g21446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="entry name" value="TonB-dependent receptor, beta-barrel domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="Beta-barrel_TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="Beta-barrel_TonB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="TonB-dep_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF89">
        <property type="entry name" value="CATECHOLATE SIDEROPHORE RECEPTOR FIU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="FERRICHROME IRON RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec_b-barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56935">
        <property type="entry name" value="Porins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0798">TonB box</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB-dependent receptor-like beta-barrel" evidence="12">
        <location>
            <begin position="36"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TonB-dependent receptor-like beta-barrel" evidence="12">
        <location>
            <begin position="209"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21446.t1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40700" checksum="8ADF499AFD6267FD" modified="2023-02-22" version="1">MSTTTATVARATGSARPNPSNPGTSREIPISIRTTEYAIDRTGVTSAFTWNVGGHELEAGLWYEDNGHSVQRNFYYIDGPITDDFFLRNPDQRVWHQRYTTITRQFYVQDRFRLFDDRLTIDIGAKSPHTRTSVRTPLGSYANNSSLTSKKGFLPQAGFNFKLNEGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSPFNVPQAAFDASAQNLKPEQSRTIELGWRGYGRGYEASVAVYDVKFDNRLLAIAQCVGILGCPALFSNVGSVTSRGAEATLQLKPMQDLSWSNALSWNDSTYDNDYVNNGVVPTRGKKTVDTPEWMFASTLAWTPGPWDMRLSANHVGKRYVTYTNDVSARRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPW2</accession>
    <name>A0A914YPW2_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914YPW2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2225.t1">
        <property type="protein sequence ID" value="PSU_v2.g2225.t1"/>
        <property type="gene ID" value="PSU_v2.g2225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="39"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2225.t1"/>
        </source>
    </evidence>
    <sequence length="471" mass="51094" checksum="9FBB76E5C38F9FCB" modified="2023-02-22" version="1">MSTEEQQHDDAQSWLSKQDPSKVKPSELNPLTEEVISRQATINIGTIGHVAHGKSTLVKAISGVHTVKFKNELERNITIKLGYANAKIYRCSNEDCPRPGCYRSAGSISPDRLPCTREGCGGQFVCVRHVSFVDCPGHDILMATMLNGAAVMDAAMLLVAGNEPCPQPQTSEHLAAVEIMQLKHLLILQNKIDLIKEAQATEQFEQIKSFVQGTVADSAPIIPISAQLKYNVDAVCEYLCKKVPVPLRDFESPSRLIVIRSFDVNKPGSEVENLKGGVAGGSILKGILKVGQEIEVRPGIVSKTADGRVQCRPIFSKIVSLFAEQNQLQYAVPGGLIGVGTKIDPTLCRGDRLVGHILGAVGTLPDIFVDIEIAYFLLRRLLGVRTEGGKKAAKVQKLSKGEVLMVNIGSLSTGGRVTAVKGDAAKITLTDPICTEVNEKIALSRRIEKHWRLIGWGTIRRGTTIEPTKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YQR4</accession>
    <name>A0A914YQR4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Malonyl-CoA:ACP transacylase (MAT) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YQR4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3128.t1">
        <property type="protein sequence ID" value="PSU_v2.g3128.t1"/>
        <property type="gene ID" value="PSU_v2.g3128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052760">
        <property type="entry name" value="Mitochondrial_malonyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170">
        <property type="entry name" value="MALONYL-COA ACP TRANSACYLASE, ACP-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170:SF2">
        <property type="entry name" value="MALONYL-COA:ACP TRANSACYLASE (MAT) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="2">
        <location>
            <begin position="111"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3128.t1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47040" checksum="72D4D65D3FE4E609" modified="2023-02-22" version="1">MLKLLNPSSLSSSKSIITRNIRRRGLPPDFPPPRPKEAEFLKDATTYSDVHSAMLDPHSSLPYPAEQLQDYLHDTEKEQHRSIKTHDSKKGRRIFKLNFDHIPIEDQVVALFPGQGAQHLKMGEKVIDCPASKALFDQANEILGYDLLKICMEGPKTKLDQTIYCQPAVFVASLAAYEKLKTEQLDLEDRLTDAAGFSVGEYAALVAGGVMKFEDALKVVKIRAEAMHECNQIVSAGMLTIRVNASSKLEEAFKAACEDAMESNDVPVCEVANYLFQGVKVIGGTNRCLTYLESNAQRFNIQPLKRLAVSGAFHTRLMSNAMHPVQHAFTGMQFEQSSCNIYSNFTGKIHSRKANEIRKALIHQVAEPVKWEQIQQLLFRKHQDFKFPNYIEIGPGRQLGSMLVNISKKAYNSYTSFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRB4</accession>
    <name>A0A914YRB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2193.t1">
        <property type="protein sequence ID" value="PSU_v2.g2193.t1"/>
        <property type="gene ID" value="PSU_v2.g2193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2193.t1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11942" checksum="67AEEF28865E17AA" modified="2023-02-22" version="1">MAFYYIDYKNHETITLVTTASPQNMCTFKISSTNQYSLKFRTSYIRDGMNMADITLSSNQITNPSLNPTKPCKPSYDFTSSQTYDALTELCCITKSNGPWPGALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRJ1</accession>
    <name>A0A914YRJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAC-A/B domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3378.t1">
        <property type="protein sequence ID" value="PSU_v2.g3378.t1"/>
        <property type="gene ID" value="PSU_v2.g3378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="63"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3378.t1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22929" checksum="7BD0C0A655BA0007" modified="2023-02-22" version="1">MTAEIVEQVAEKEVKQHDDCCDCSSDDEGVGQDEPVVMTEDQKRFAELAGLGEQVTEKGAKQSRSEKKARKLFSKLGLKLVTGVSRVCIRKSKNILFVINKPDVYKSPGSDTYIIFGEAKIEDLTQHALSDLESLKPPALAESTIDRSNVARQPAAQVEESDGEEVDATGVEEKDIELVMSQASVSRSKAIRALKEADNDLVNAIMGLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRW0</accession>
    <name>A0A914YRW0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YRW0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3483.t1">
        <property type="protein sequence ID" value="PSU_v2.g3483.t1"/>
        <property type="gene ID" value="PSU_v2.g3483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF469">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3483.t1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19780" checksum="AFA3060883FAB430" modified="2023-02-22" version="1">MPKYGLISRIGQGAQGVLVKARTIEIVKLLDYFFHDTTASLVFEFIESTLKLIITDIRRPQNDALLCHYFLQLFCGIAYLHHLNIMHRDIKPENILVTANNQIKIADFGLACLYVPKSAKTYSHQVVTRWYRAPELLFGSITYDFKIDLWASGCVLAEYINGSPLFMVKKSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS05</accession>
    <name>A0A914YS05_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS05"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20173.t1">
        <property type="protein sequence ID" value="PSU_v2.g20173.t1"/>
        <property type="gene ID" value="PSU_v2.g20173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20173.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19179" checksum="A9B3F49F624AE7BC" modified="2023-02-22" version="1">MDTIAEQSNLSDLPANKEDDLMDTAEHEHFIAPTFTLATGNAFDAFDETTDNGQDLPEYYFQNCDGKSELHEVNVAGILHRCSDCIDDIKGEKPCAYCESEEHGITREKMWSSIPNCPDFVDFHETPIDGLKDYLIKLTELPGISRVLVYSHNGSRFDTHLDYRSLRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSE6</accession>
    <name>A0A914YSE6_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YSE6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2937.t1">
        <property type="protein sequence ID" value="PSU_v2.g2937.t1"/>
        <property type="gene ID" value="PSU_v2.g2937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2937.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16298" checksum="400E87F52122AF20" modified="2023-02-22" version="1">MTLYNLYIFNSKGECICYKEWRRENKREITQEGEFKLIYGLILSLRSFAQRISTKDGQQYIKFFTTSGYKMNYMETATGLKFVLNSDPDAIGIPELLRSIYSIFVETVVKNPLVTTESTIESQLFHSRLDSIVKSHHSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YT54</accession>
    <name>A0A914YT54_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YT54"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20613.t1">
        <property type="protein sequence ID" value="PSU_v2.g20613.t1"/>
        <property type="gene ID" value="PSU_v2.g20613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20613.t1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12046" checksum="501A07B8D26FA81F" modified="2023-02-22" version="1">MPPTAPVRSVTTAEKKFGVSPKPTAASISAASKRLATPLRPITTERKTATASERKPFAPSASKRTPSSNPRGTPKAPSTAPPRAMSATRPILAKTENSAHVTPTRNKKYENIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUL1</accession>
    <name>A0A914YUL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21168.t1">
        <property type="protein sequence ID" value="PSU_v2.g21168.t1"/>
        <property type="gene ID" value="PSU_v2.g21168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21168.t1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7207" checksum="B46672DB86801BF8" modified="2023-02-22" version="1">MTSGGLIYAVSGVPGLIAANSITNSAYQFGYDMDAIVGGAHNGAADAMRHCYLMCRMTKTFGSTIADVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YV65</accession>
    <name>A0A914YV65_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YV65"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21399.t1">
        <property type="protein sequence ID" value="PSU_v2.g21399.t1"/>
        <property type="gene ID" value="PSU_v2.g21399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21399.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30380" checksum="8B9D6B7087F5FDB6" modified="2023-02-22" version="1">MPASIQCEEEHSFIPTLPRYNYLIEKTCLEIGVYVPANAPWGPNNFINRDGTKMGIKKWGFVSFIIGGTREPGPGGGEEKATIMCKQGIEYTWHDVGPTTVRHLLCKRPAIPQPKKVSPALIKNDEGRNGSYVCPAGFDLGNVCGGHFCYRVVSVPDAKNRMIDDNFCAEFDRDAMPAVIKCKEENDLIVTLSDNEDIAISNGIAIGLYIPATKPWNPNNFVTYDGSKIEYLNWGIFDSAEGPYKEPNGFLNGYPERIVNYVKFPSTLEIFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YVW5</accession>
    <name>A0A914YVW5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YVW5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3798.t1">
        <property type="protein sequence ID" value="PSU_v2.g3798.t1"/>
        <property type="gene ID" value="PSU_v2.g3798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3798.t1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8829" checksum="B919447DA62A6B5D" modified="2023-02-22" version="1">MKVGPIKSCMKILPYRSMCPSGMPSQFTLRWFVKAGMCCAYPFGYCHGELVFNEEAIKTKKECEELCLGKIDSGNTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWG4</accession>
    <name>A0A914YWG4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWG4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4897.t1">
        <property type="protein sequence ID" value="PSU_v2.g4897.t1"/>
        <property type="gene ID" value="PSU_v2.g4897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401:SF6">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4897.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29323" checksum="33B230263473C4C4" modified="2023-02-22" version="1">MSFGSIKGILHFHLTNFKKEMLVFFLLSFFIVFSNAAKFVDQISRQSSQLLVESQNGKMIRQCSCVEQNECVIDLKNQMSACFDNCFHKVKDAGINVESLKGCFHQKQYIVDDLVTCIQSTMKTCANSQDGKQIPYTDINIFFTKGEKKLHQQAEMFLATMGDSGRALIDQALDVGACIKDCVIQKNTGGYCFDHKRCQPLIEAKQASKSLKKCIKSIGWKNEASDLCECMVKAGVSEMGQYCSMLKTITGSERRGHRKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YWM3</accession>
    <name>A0A914YWM3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YWM3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g437.t1">
        <property type="protein sequence ID" value="PSU_v2.g437.t1"/>
        <property type="gene ID" value="PSU_v2.g437"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g437.t1"/>
        </source>
    </evidence>
    <sequence length="530" mass="59113" checksum="AEFE53A91FFE5D0A" modified="2023-02-22" version="1">MQILQVPSPEPPKSPSDDEIPYNYQSAKQPLSQQYSHERRPRVTSWFTDVGDNNKKDVATTIESSFMTPTENSKEGGGDHLDAREQYIKSKQYRDFMEPNPKKGGIAKKSSTKIQEKTMEDFNEKFAAITTSNENLEKEDSQNATKLSAVVNENYKLGTTPYTRKSMPAETRKESEEYLHKPFQQSILVKKQSPPQLPLTNNFDASHSSQGSYWSSQTELDKAFNHKKQSYTERAIDIGSYKASPVEVFDVDRKHSDTHSSGTLHSSSSLDDVEATPKAPRHPLKSVAHPSNHPPSNNPFDISTSSQSRRSIGVDDSPGTPIKYKIKESNKSEFHEMPVVRVAVKSMVLPQKGVITGIARPYSFQGGDSSKPQSREDLSSTPSRSISSLAGSSSQIRDSQIAESTASSTIRVDDIDRNNARSPLRDNSLMTTSTIVNMNSTSIRDWSSSSSSITDSRKESRIQNSRITPQKQGFDVIIRPRDSPIDTNRPQSVTPSTTTEFIPRYTNSSTTLTIKSSPDYSQNRHLSTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX22</accession>
    <name>A0A914YX22_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphomannose isomerase type I catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YX22"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4656.t1">
        <property type="protein sequence ID" value="PSU_v2.g4656.t1"/>
        <property type="gene ID" value="PSU_v2.g4656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF2">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4656.t1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11743" checksum="EBB5A952EA9C93AE" modified="2023-02-22" version="1">MQRIDCTVNNYAWGKEGNESEVAKLFAAGHGKFKVSSKMPYSELWMGTHPDGPAKVRDSAENLSKFIAKNDFENGKDEIHLPFIMKIMSIKHSLSLQVHPNRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YX45</accession>
    <name>A0A914YX45_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YX45"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4221.t1">
        <property type="protein sequence ID" value="PSU_v2.g4221.t1"/>
        <property type="gene ID" value="PSU_v2.g4221"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000141">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4221.t1"/>
        </source>
    </evidence>
    <sequence length="352" mass="38442" checksum="7AAE6EA84D92A0C6" modified="2023-02-22" version="1">MNPTNYTQKIIGIEGSANKVGVGIVTEMELIANTRATFHGEPGEGFRPTEVARHHQRILPDLIADAFEQAEIKDASEVVAIAYTKGPGMGAPLQAGAVAAQALAMTLGIPMVPVNHCVAHVEMGRSITQTRNPIVLYVSGGNTQILNYSRKKYYILGETLDIAVGNCFDRLARVLKLPNEPSPGYSVEQLAKQGTKLFPLSYSVKGMDMAFSGILTQISKQGKALMSQKDTKYSAADLCMSLQETVFAMLIETTERAMSVTNIAEVLIVGGVGCNLRLQQMMQLMCDDRSAKLGATDARYCIDNGAMVAHTAVLMYKNGVYTNPYEGCEYTQRYRTDEVEVLWRKGEQLPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YXJ1</accession>
    <name>A0A914YXJ1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome b561 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YXJ1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4368.t1">
        <property type="protein sequence ID" value="PSU_v2.g4368.t1"/>
        <property type="gene ID" value="PSU_v2.g4368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000001">
        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4368.t1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29087" checksum="3C0B8D110E24BC6E" modified="2023-02-22" version="1">MGNLNNFSMSENKYEVCTVLYWVQKIFATTMFISLVTWIFGHAGGVGFQDEPKLEFNFHPMLMSFAFIFINGEAITLYRGCRYVAKKRTKAAHGILQFSGLILASFGLKAAWDSHNYEAKPIPNLYSFHSWMGITTFSIFILQFLGGFLTYALPYASMDLRKKAMPYHRLGGIVILLMTLTSAMLGYSEKAAWAFKCWTVDKKFCPILFFGNIFALSMVCYVITVFLIVIQPEWIRKPLPGEGPVPVNEEESAHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZD5</accession>
    <name>A0A914YZD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thioredoxin-like fold domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family. DsbC subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YZD5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5863.t1">
        <property type="protein sequence ID" value="PSU_v2.g5863.t1"/>
        <property type="gene ID" value="PSU_v2.g5863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03020">
        <property type="entry name" value="DsbA_DsbC_DsbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.70:FF:000002">
        <property type="entry name" value="Thiol:disulfide interchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.70">
        <property type="entry name" value="Disulphide bond isomerase, DsbC/G, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033954">
        <property type="entry name" value="DiS-bond_Isoase_DsbC/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018950">
        <property type="entry name" value="DiS-bond_isomerase_DsbC/G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009094">
        <property type="entry name" value="DiS-bond_isomerase_DsbC/G_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051470">
        <property type="entry name" value="Thiol:disulfide_interchange"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008657">
        <property type="entry name" value="PRK11657.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35272">
        <property type="entry name" value="THIOL:DISULFIDE INTERCHANGE PROTEIN DSBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35272:SF4">
        <property type="entry name" value="THIOL:DISULFIDE INTERCHANGE PROTEIN DSBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10411">
        <property type="entry name" value="DsbC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54423">
        <property type="entry name" value="DsbC/DsbG N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Disulphide bond isomerase DsbC/G N-terminal" evidence="7">
        <location>
            <begin position="44"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="8">
        <location>
            <begin position="134"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5863.t1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30366" checksum="B75060916027EB90" modified="2023-02-22" version="1">MTVIGYAFYSTFALTEKDKLMLKKILLLALLPAIAFAEELPAPVKAIEKQGITIIKTFDAPGGMKGYLGKYQDMGVTIYLTPDGKHAISGYMYNEKGENLSNTLIEKEIYAPAGREMWQRMEQSHWLLDGKKDAPVIVYVFADPFCPYCKQFWQQARPWVDSGKVQLRTLLVGVIKPESPATAAAILASKDPAKTWQQYEASGGKLKLNVPANVSTEQMKVLSDNEKLMDDLGANVTPAIYYMSKENTLQQAVGLPDQKTLNIIMGKVMLPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0D2</accession>
    <name>A0A914Z0D2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0D2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3735.t1">
        <property type="protein sequence ID" value="PSU_v2.g3735.t1"/>
        <property type="gene ID" value="PSU_v2.g3735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12670:FF:000002">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3735.t1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45231" checksum="0CA1D63540284B26" modified="2023-02-22" version="1">MLTNSLILWSNYHGRIQLDDWNTLKYSCCVLSDKDNCDWTPYLTSTNNIDYTGDNSTCGKILTPIINATGYFNIDPYNYYEDCYSGSHITYKKFGKPQRHFYQKWKQNRDAAAMVNTADLLNRNSTDNLMGYPCYQEDYVAKYFNDPAVQDAYNIDPAWRNAGLKFGDCNMDLYNNYHLTYDDMAPYFDIMIKNLTGFRILVYNGDVDTVCNFLGDAKFIDGVAKKHSFSATTPRQRWYFRSSVAGFYQRYLGGNNFQIDVLTVKGAGHMVPMDRPGPSVQMITNFILSEQPNYSYSQFIDPTIKPAPLISNSSNPSSVTTMGPSSVTSPSMSTSMSTSMEPMKTTPPASPVTTPPTIPTNSPITSSNTGTTISSTPPTSTIPTSTAHSILFSLPLLIFSFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0I6</accession>
    <name>A0A914Z0I6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0I6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5671.t1">
        <property type="protein sequence ID" value="PSU_v2.g5671.t1"/>
        <property type="gene ID" value="PSU_v2.g5671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.2010">
        <property type="entry name" value="NAB conserved domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006989">
        <property type="entry name" value="NAB_co-repressor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039040">
        <property type="entry name" value="NAB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006988">
        <property type="entry name" value="Nab_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038398">
        <property type="entry name" value="NCD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623">
        <property type="entry name" value="NGFI-A BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623:SF10">
        <property type="entry name" value="NGFI-A-BINDING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04905">
        <property type="entry name" value="NCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04904">
        <property type="entry name" value="SAM_NCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nab N-terminal" evidence="8">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="NAB co-repressor" evidence="9">
        <location>
            <begin position="367"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5671.t1"/>
        </source>
    </evidence>
    <sequence length="510" mass="55681" checksum="A3AA63E960A8FCC5" modified="2023-02-22" version="1">MSSSASSDRQRTTSTSTPPIQHQQLQQQQQQQLQQPSTSSSSTIPGSSTAQPGPASNLNNEQWAVFINQRMSGMPNSTTLPEWQLQAVLFHAKLTQYYDRFISLGGDDIDQLMQCDETEFLEIMRLIGMASKPLHVRRFQRTLADFSKDRATFLRQAAVHIGPPPVMDFPTSSQTSSLQAAIQFLIPGFNPTEQYLPTTTSITSTLSGTTLQPPPPPSMAVPSSSTSLINVESIVPPTSMPRLYPQTSTPFFLSQPSTSSSTPSTASASASATANVMPVPSSDLLNLVGSSISALTIPSISPSIIATTSVASATTVITSTISRTESPAIAGPSGCGSNQSIPSPGSDTEYTGDPFEGGILPETDIPQIIKLSKALYLQKPDLHILEPRYVQNKKKLPKELIDVMKMPSEDKNRVIEFRKFSAIYGRYDAKRKPDKPLSYHELLVNEAAAQLCLIQPVLLTRRDELFPLARQVVRESNFPGFRALSRNERKRTFDLKSERSASPHSVASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0K7</accession>
    <name>A0A914Z0K7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0K7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5887.t1">
        <property type="protein sequence ID" value="PSU_v2.g5887.t1"/>
        <property type="gene ID" value="PSU_v2.g5887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5887.t1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21242" checksum="5522867229A69A66" modified="2023-02-22" version="1">MTKLCQADVVAFDVEAGFVCQNADGIQQAALLQIALKDCILLIDIYTLVQTVDDEHIKIFFELFLGTDIKRIGFAIKSDLDYLRNTFEWLPEHIRKIQPIFHCVQKFAENVYTKHAFSDIFPPLNGTSLKEIVYKWLDKDLDKTERQGNWLKRPLSKEQMIYAAMDAKFHWDVFYYVKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0W5</accession>
    <name>A0A914Z0W5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z0W5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6366.t1">
        <property type="protein sequence ID" value="PSU_v2.g6366.t1"/>
        <property type="gene ID" value="PSU_v2.g6366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF84">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="47"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6366.t1"/>
        </source>
    </evidence>
    <sequence length="641" mass="71770" checksum="7CA109FB1F7254C6" modified="2023-02-22" version="1">MQLSKKNNSSEKDALLGSNKQLSKHYSSATTTTTNFLQKVIPLTLAWHGIRVSREKCKTSVILDNIDGKALPNEVVALMGASGAGKTTLLNSLMARNLKGLKVDGEIIVGGNTNIKIGDVSGYVQQDEMFMSTLTVFEHLMIQAGIRLSGIPSDKIKQRIEEIMDELGLTKCKNSVIGLSGIKKGISGGEAKRLMVASVLLDNPSIVFLDEPTTGLDSHMAQSLMDSLQKLAKNGRTIVCTIHQPSSNIFNALDKVIFLGDGKLAYFGPPKEVLPFFDSLELICPDDYNPADYIIDILAIDRQNDNDKVALERVHKISKSFTESNLTKEIYEDLKTFQGYGAEKEIDKILRRKASWFSQFRIILKRSFIDNKRNPALSRAKFIQKIIMGLFIGLLYFHQTSSITDVGVNNINGALFFIVSELTYSTLFGILNFMPADFPLVVREHFDGLYSVSAYFIARIISYMPIFILDGIFMVSISYWLSGLVPTFQNFFINITIGILIEQSAAAFGVLLSTISPSYAIAISIAGPILSLLSLTGGLYANVGELPGFIRWTKYFSWFKYGFEAMTINQWRGVETRWKNDKSMQQCIGNISHCQSSAELLEKYSFEETNFWYDIFAMIAFIFGFYIIAYIGLYIRVRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z155</accession>
    <name>A0A914Z155_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z155"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6095.t1">
        <property type="protein sequence ID" value="PSU_v2.g6095.t1"/>
        <property type="gene ID" value="PSU_v2.g6095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6095.t1"/>
        </source>
    </evidence>
    <sequence length="220" mass="23970" checksum="D2140649C5AAC719" modified="2023-02-22" version="1">MDGPTPGPTHAAPHNRLIRTAPAHRPAVLLEGYFIMQAIARLSRFCWQYLCHLGSTVCRSGLLLSRPLSLVRRLYCSTSGHHHVRYGADLVAPGLCGGVCTPWPCGYWCIGTIHHHARSGLVSDLRLFPATRIGHWRDSGGLLPRWHLVQCDDFSGPWRPGPVGCHYVGHHLAGSYRHPCPDLLPGQPMAGSQRLGHVLVHCSGGDSAHCPGHYCAIPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1I4</accession>
    <name>A0A914Z1I4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z1I4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g4127.t1">
        <property type="protein sequence ID" value="PSU_v2.g4127.t1"/>
        <property type="gene ID" value="PSU_v2.g4127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040435">
        <property type="entry name" value="Put_GPCR_Chromadorea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37441:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37441">
        <property type="entry name" value="PROTEIN CBG16518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="58"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4127.t1"/>
        </source>
    </evidence>
    <sequence length="439" mass="49646" checksum="4EE0DC271D194B81" modified="2023-02-22" version="1">MFIHKFDTSPTLNWAYNCTPEEDAKILCYDNDKDNLADHVIPAITLTLSIIGFIINTGFIYFVIIGIKTKTLPFKGYSLLLNRSVTDLLVALLTTIFVALRKFDKINGKTPDPNSQGHNVNHSYYVLEYVIPHGRTMFTLLLTVDFWAVAGAYGIMAMLPFIAVRNPIFYRTHITNRVVVTVMVISWLVGAIYSALVVSLSSNNAFNVFNSADDLIQWTVSDEDYVLSISNLFIVVAAFFTGSFSYIFIIVYLYKKSSKKGNAGAHLANIVRMAINIGCFATTCIVMAGFVSLPLFLKSHIDDLDVLSNVSICKTAVQTFELSYIMAIWTTLAMTGWMLRIIIDPVFNVLFDIRFRELLRDRLRILRNLSQSPTPPSRVSAPNFLARNEFLRKCAEMNVIPLSISGNYFRFRSPSEVPPEEIRPKPKKIIHIRFDELVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1K4</accession>
    <name>A0A914Z1K4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1K4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6233.t1">
        <property type="protein sequence ID" value="PSU_v2.g6233.t1"/>
        <property type="gene ID" value="PSU_v2.g6233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037134023" evidence="1">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6233.t1"/>
        </source>
    </evidence>
    <sequence length="119" mass="12951" checksum="E1427507E32AA214" modified="2023-02-22" version="1">MKFMIILLAALFGIAFGQQRRCPANMIQLFNGVACSTDAMCYNMAPGYFCLNGYCCANSASSPSGYGSSCTYQSQCSFANSQCLNNICYCASGYDYDGYNCQGGQSGNPCHILFYFCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1K8</accession>
    <name>A0A914Z1K8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1K8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5775.t1">
        <property type="protein sequence ID" value="PSU_v2.g5775.t1"/>
        <property type="gene ID" value="PSU_v2.g5775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5775.t1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30129" checksum="4C6419FBF8E8283E" modified="2023-02-22" version="1">MKIPDSRLKSVSKTITQEIKEEMPPKQQLQHQQQQKQQTNTNANSEKTIKSRDPSPASGSRIPAPSTVSLPVKRERSISPTATNLQKHKPPPPSESPQQQQQRTPKRGPPPVKRVIQKVINPEELMLERENTRTLITKEQHKEIAVDPGVPQVNESPKIKPKSVVRPMPKNPSLAASTPAASILPPPPPSTSTSSSSSSHSTNNSKELSRTKSNSIKTGTVSSSTTSTMSSRRQRPRSALPTRQTAASAAKSAAVASAAAASIDRSKRVETKIPKVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1W4</accession>
    <name>A0A914Z1W4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1W4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6694.t1">
        <property type="protein sequence ID" value="PSU_v2.g6694.t1"/>
        <property type="gene ID" value="PSU_v2.g6694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038032308" evidence="1">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6694.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12005" checksum="504EAB798D7FD980" modified="2023-02-22" version="1">MKLLLLFFLFNFGIFCYGFNQNRIIDGVAVPVGEYQNVVRIHPMSINYTHQYMHIWKNDSFEFDPTVSLFTCTGTLISKRHILTAAHCVTDSLYFSQMNEMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z1Y5</accession>
    <name>A0A914Z1Y5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribonuclease P protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z1Y5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6371.t1">
        <property type="protein sequence ID" value="PSU_v2.g6371.t1"/>
        <property type="gene ID" value="PSU_v2.g6371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6371.t1"/>
        </source>
    </evidence>
    <sequence length="514" mass="60373" checksum="7E24C176DEABF8E9" modified="2023-02-22" version="1">MLLHGLRSFCRPMKNVINAQFSFYLFNQLNIGRYNYNFNRFYVIYGDSSLKEHRNARIIYDIGVVDDKEPDYFVNLEKLRECEAQRERSYNPRDFSRAISSCLQLQRFKLGISIIDFLLTRNVAANRDMINIFKLISEAYTHQAISFEKGKDMIEKLVPLIQNLPPFISSQFNETAKLFLEKNIDDTLNNDQSAAVVIPEEKLFVTLLTHAIRRRDLDELRKLALRYPSFSSYGTPLFDEWFKWVEEVPSQAAELVQIFMDSMTMNYLELPTEFFHNFIDRYNKIPHLPSFKRVQLNSTRECTNCSSKFDPKPSFTDEEFDEFSKYVFEYAKRSQIHVKELARIELTYVPNMIYGTSYLGNIKLLKIFVEQLLANFSAVGLISKFPLPPKIASEILQLDKVFYFKTHTTSYDDDMMLLLIYTKCGKDTYYVTNDQFRDHLRRLDESNCSIPKNRVNKILGVRNLQMNKTAGMLEKPSEISPFVQKTSSGYHVPLRHTFVTAKESYDYYCCHKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2A8</accession>
    <name>A0A914Z2A8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z2A8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6031.t1">
        <property type="protein sequence ID" value="PSU_v2.g6031.t1"/>
        <property type="gene ID" value="PSU_v2.g6031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6031.t1"/>
        </source>
    </evidence>
    <sequence length="529" mass="58592" checksum="76E920C763CC67A5" modified="2023-02-22" version="1">MDNYTQNQISNGLNYNANEPTFDQPLNVFNGNLEYTISRNLLMDGEGLENRLHDMRHHILHLFSIMNIFNERLADSENFDIDEFSATFLELSSLVGELCNICREFDELHEKIASEAFKCLDKYEENANICGGHLLNAKLNKARQIREIIKSWHHSTEINEIHMVEDMNLEEETQVNSYYDSVHNYQILSRNIPTETTGYTYVADIPPPTLPTSFFVAPTSMPSFSGESIQMQFKEESDNERTTELPTDLMSSYSMAPAPISNATERPSSHNSPINFVPPMISQPSSSSYNTPAAMSSSNNLPPMNIPPPAMAISSQNISSLQSNMLQPQPNISSSDPKVILPSFQSKQQMPPKPASVLIPGLNIANTAPLFAQAVSSNSNSSTLSEPIPTLLPTAISSGSAINNFGSDNFRKQNPQIAPIINLNISAMGSKSPAQNPISQSSSSSHIPSLLSIEVPFPIEILKRNQNQAQQQRFNNRSRRSPVVNTETKESTVKEKESQSVKSDEPMDTTDQPVVEETPDDPINDTPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z2N2</accession>
    <name>A0A914Z2N2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPS8 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z2N2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6328.t1">
        <property type="protein sequence ID" value="PSU_v2.g6328.t1"/>
        <property type="gene ID" value="PSU_v2.g6328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01210">
        <property type="entry name" value="PTB_EPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000289">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033928">
        <property type="entry name" value="EPS8_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="508"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6328.t1"/>
        </source>
    </evidence>
    <sequence length="628" mass="71830" checksum="AFB1B834A3C62623" modified="2023-02-22" version="1">MPGRRGGSVGPSPNYDSEPSYHVEHLATFAVGRQFGLQSAHDGIRKLKQMEKQSAIWAQPLLLKLKPDKVSVEDENGEIVEQFPMELIVEPTAHQTHDNMDTYNNILLFVVKEDPRNAGRKQTPTNPTEMHIFQCVRVSAVDVAQDMLLFSRGQIQKVRGGRRDTGYGGSIDTSPYGPLPQQNFYRDDASPSSNSSEAIDMNVNTLNRCFDDIEKFVARIQSAAMAQREIEMLRIRMRSKPRGKNEIPGILQLRAQMPQPAEFYEILQKFKLSINILTLVQNYIHDPNAPELLHFLFTPLKVIVDACNWGLGQDIAVKVISPLLSFEAVDLLKQCLNNAEFDLWMSLGQYWRMPAEEWTGPPPPPYRPVFRDNFAPYGYPQQASQRQPPSQIHRGSSAPPTQQYPSSRPPPRSADDIDLERVNLEKERLAFERMKILDRERRLEEEEQRLRREEARIEAERKLLNIEAQKARSASGNVYISTTTQSPNKSSKQGNPQVQAFLSDLLKHNRKIVEVLYDRPKQHEKELTVARGEYLEVLNDEKNWWECRNNQNLVGFVPHTILSVLRPEDVQTILNSSNGFNDANSIPNYNPPATIESQSLSPRPGMMTDETPDYIKQRQGKRGEFRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3E0</accession>
    <name>A0A914Z3E0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3E0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6552.t1">
        <property type="protein sequence ID" value="PSU_v2.g6552.t1"/>
        <property type="gene ID" value="PSU_v2.g6552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6552.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16579" checksum="9BA85375B9487CAE" modified="2023-02-22" version="1">MGTIGATVKTWKDIMGFNDTQMSLKEIENYILGEFGENVFHPNDDVNRRLIESFICTSNRNFLSEHIKPPIRIDRIKWPTAETFTKMKIEKWDDCHQPVAAFMDKEWDKFKPFLDFGFNYDKNLIERFVKYRNDFVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3J9</accession>
    <name>A0A914Z3J9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3J9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6601.t1">
        <property type="protein sequence ID" value="PSU_v2.g6601.t1"/>
        <property type="gene ID" value="PSU_v2.g6601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6601.t1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18368" checksum="00D6B4AA97520A64" modified="2023-02-22" version="1">MPVNVVIASAAAVVVPQAVPTDMCDEEDSYPTFMPSSPKSSMNSQMPKSEGKKWFDEDIFEYSVKDINHRSLQSYDFDTSDNEIEEGCDALDVFFMDEDGASMARKRKSFQWDSVAEKRHCDEEVISPKSTSTPIPIPRPVKCDHQVVLDTLVPMRGFFQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z3T1</accession>
    <name>A0A914Z3T1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thil AANH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z3T1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7012.t1">
        <property type="protein sequence ID" value="PSU_v2.g7012.t1"/>
        <property type="gene ID" value="PSU_v2.g7012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002937">
        <property type="term" value="P:tRNA 4-thiouridine biosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="PPase_ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000003">
        <property type="entry name" value="tRNA sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000029">
        <property type="entry name" value="tRNA sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026340">
        <property type="entry name" value="THII_Thiazole_biosynth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050102">
        <property type="entry name" value="tRNA_sulfurtransferase_ThiI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04271">
        <property type="entry name" value="ThiI_C_thiazole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43209">
        <property type="entry name" value="TRNA SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43209:SF1">
        <property type="entry name" value="TRNA SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Thil AANH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7012.t1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31895" checksum="7799A5235B847A7C" modified="2023-02-22" version="1">MLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAVKSKIEAEEEKFDFSILDKVVEEANNVDIREIAQQTEQEVVEVETVNGFGPNDVILDIRSVDEQEDKPLKVEGIDVVSLPFYKLSTKFGDLDQNRTWLLWCERGVMSRLQALYLREQALTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z533</accession>
    <name>A0A914Z533_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z533"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5366.t1">
        <property type="protein sequence ID" value="PSU_v2.g5366.t1"/>
        <property type="gene ID" value="PSU_v2.g5366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5366.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12576" checksum="28982AE723440393" modified="2023-02-22" version="1">MSDPHYAMGTYYFSSEVISFTLIGMSVGAWICTLVTIGVCLCANNSKVPLLAYRLTATTASARTPMEVIVEQETQIVTTTNTGPMEEKVVSKSKILSNKSMIKTKSATASAATPTKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z592</accession>
    <name>A0A914Z592_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spherulation-specific family 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z592"/>
    <dbReference type="WBParaSite" id="PSU_v2.g7849.t1">
        <property type="protein sequence ID" value="PSU_v2.g7849.t1"/>
        <property type="gene ID" value="PSU_v2.g7849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037264395" evidence="1">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g7849.t1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27003" checksum="20FB6E9AE317DC81" modified="2023-02-22" version="1">MLKLFTVFVLFFIIVLVEAKQPSILVPLYIYPEDNAWQPFYNAIKNFSNVKFDVIVNVENGPGNGKYPGRDYIAGVAKLRLFSNVRIIGYVYTSYGKRSAAQVNADVNKYANWKSYTKDNIRIDGIFFDEVPEAANMATYLKILTGTNVPKPFYNVTDNIVFFESPWSQYSSNQLTQVKGLESKSSVIIHTFTGTDAEQQSTVAKWAAAGIASVYITTSADYDSVSSKWIQLCAAVENTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z667</accession>
    <name>A0A914Z667_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z667"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5734.t1">
        <property type="protein sequence ID" value="PSU_v2.g5734.t1"/>
        <property type="gene ID" value="PSU_v2.g5734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="319"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5734.t1"/>
        </source>
    </evidence>
    <sequence length="668" mass="76445" checksum="DC11D7007306B4D9" modified="2023-02-22" version="1">MNINTLTKAQLEMKKFGEINRLNESEPESRPHRNPDEEILSWQLQTVKYEKNDITKTKTLFLSENSHFCSKSFEELEPINLCDMKVPMIHEGKYLVCQVKGKPYSVIGLATPSPYFGVHTLIEDLNGDIEELAMYNFRHKVDDVNWLPLGTILIIKEPWLRYGSQSKTASLRVDSPSDVIFVDPIDNEVLEKIGATKWHDSKLSKNAEVWQKEANECFKKGKYEMALKLYDRAIRFNPELSVLHSNKSLTCLRIGAFYDAYEAAKIGLEKGGNREKALYRMGQAAYDMREWQNAANHFAAILLESEKHEPQFEVADYVGPIEIANIPGKGRGIIASEDIKEGTLLVVSKAFSTSLCQDFLSLLGTIQSFKKQGATADQLLQVTQIMKNLQLNPQLGKEIYDLYAGDLEQNVDIPFGVIDAARVQQISACNTFGTTDVGENSESIDKIRLFVLPSYFNHSCIANGKREFFHDVMVVHATADIKKGEEIFVPYINLTYDFLERKKKLDFWKFTCTCALCELDANDENCLKRNEMVKKYVKFANGSYNLYSIIDQGEALLKKIRETYVNRNELKIVLVQFLDTLYAAYYDTGNKLKCAKILEEIISLMDNPLKYTEKIKTKYLDLAHCYLSLRNNRGYKEMLQKAMKLSFCADMEHFKAIYPMIGRQLSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z772</accession>
    <name>A0A914Z772_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z772"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8172.t1">
        <property type="protein sequence ID" value="PSU_v2.g8172.t1"/>
        <property type="gene ID" value="PSU_v2.g8172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 5" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8172.t1"/>
        </source>
    </evidence>
    <sequence length="760" mass="86526" checksum="C04BCF89EAA87305" modified="2023-02-22" version="1">MSANYTSKLSHFQDIFKSSEEIWNKKQLTRNEGPHKHSAVSEIFNATAKSSTLLTPNTTRDYDTNTIPANYNINSTQAIEGLVNDTVERTRLESERNFLNQHVFQANHIISRRSVPFTENSKPINQQVLMSSAAFKPLDTFTEEVFAKHIEEALTSGGIEKVLSSLRAAVKKVDDPAIDDIWEKIFAVCQTVLLEGDMEVDQLRSSKKWMRHVVHYSTEYLQNQFLLYMEGTIEKNLEQAQRGGIPGTLPLIEAFLNVAHLEYGKVEDTLYGKHPVWCVLFHTLRLGDYAAAGKVVETLLNVPSCSILVSTINNLAKDVVIDYSVRVKLNAEWHHEEVNCTDIFKRACYGILLDFDCMDVNDNIENWLWSKLISVKFDNNHNLDRFLNLQRLISVEYGEEWFLNESNGGSSLVYFSALLLSGQLERAIEILYRSDMLVFGTHLAVLSYSLKLLILTDKVSDPLFISDPADATLCKFNFARIVILYVKRFEMTNVRYALNYCFFLSKLQFDSSENGSNLFEACVSRLVYVSGQADVILGKVNIDGIRMHGLLDRFEKYINVTDVISRVALDTSLNGDNLAACRIYCLAGRANEAIKLMNRQLSICILSFSSQTEVSVRLAEKLMKRYTKSRDNTIQTQHLSTLDTLIRCYHIFRMHKENRFEDSLVEAEQISVVPFDPDSVSSFIEKFEMIPEEIRNLLPDLCLVLMKSTVKQYEKALPKSPAQMKMQKIAKAILLFAAMIPFRFPVAVNTTLLQLQAQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z7P4</accession>
    <name>A0A914Z7P4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z7P4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6270.t1">
        <property type="protein sequence ID" value="PSU_v2.g6270.t1"/>
        <property type="gene ID" value="PSU_v2.g6270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6270.t1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17288" checksum="A642BBDC7979215F" modified="2023-02-22" version="1">MPYEKTVETEQTVNTLNRKDDGYENLEISKYGSKYVEEKSAIKTFKPKLSKEAQTQEGTSKKIPRPIQQEKTAKHVKGRADPMEAPPSSAVSFADERKPPESEGNSEYVCEALCQKRESTSFDKNKKDVVPERLTSSVPTANNKKKKIGCCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z822</accession>
    <name>A0A914Z822_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z822"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8014.t1">
        <property type="protein sequence ID" value="PSU_v2.g8014.t1"/>
        <property type="gene ID" value="PSU_v2.g8014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8014.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14094" checksum="1CC2562A6E879B84" modified="2023-02-22" version="1">MVRSPPSPAVAVPVMDAAGFAAAVAAAVAQLQINNPATANVSQNLPSIPKFICDPAKPNGASLWFDQLDSLFRLQPVTDTEKCALVINALDSSTFEKVSRALLPDPIKTCVDYNKLRDKMIGLFEYGMERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8D8</accession>
    <name>A0A914Z8D8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTH cro/C1-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z8D8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8116.t1">
        <property type="protein sequence ID" value="PSU_v2.g8116.t1"/>
        <property type="gene ID" value="PSU_v2.g8116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000015">
        <property type="entry name" value="Endothelial differentiation-related factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8116.t1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17366" checksum="59211DA3E2FFC78D" modified="2023-02-22" version="1">MSKMGRMESDTTQDSVTILRKSAPPIKTCRSTAEIAAAQRRGAEIETSKKFGAGGNIQHGMQKNALKLDNETEELHHERVSLSLARAIQQGRQGKEMSQKDLATKICEKIQVVQEFEAGKAIPNAQVLGKMERALGIKLRGKDIGKPLVPPPAKPAAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z8R4</accession>
    <name>A0A914Z8R4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Band 7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z8R4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9067.t1">
        <property type="protein sequence ID" value="PSU_v2.g9067.t1"/>
        <property type="gene ID" value="PSU_v2.g9067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000026">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF127">
        <property type="entry name" value="PODOCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9067.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22012" checksum="6B97B2ED56FEECF5" modified="2023-02-22" version="1">MPCIETWIKVDLRTVSFNVPPQEILTRDSVTVSVDAVVYYRVCNATISVANVENAHHSTRLLAQTTLRNMLGTRNLSDILSDRDNIASAMQTLLDEATESWGIKVERVEIKDVRLPVQLQRAMAAEAEATREARAKVIAAEGEQKASRSLKEAAIIISQSPAALQLRYLQTLNSISAEKNSTIIFPLPMELIRHFIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z9H0</accession>
    <name>A0A914Z9H0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hint domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Z9H0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g6895.t1">
        <property type="protein sequence ID" value="PSU_v2.g6895.t1"/>
        <property type="gene ID" value="PSU_v2.g6895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052140">
        <property type="entry name" value="Dev_Signal_Hedgehog-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001657">
        <property type="entry name" value="Hedgehog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46706:SF12">
        <property type="entry name" value="PROTEIN QUA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00632">
        <property type="entry name" value="SONICHHOG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Hint" evidence="6">
        <location>
            <begin position="260"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Hint" evidence="5">
        <location>
            <begin position="370"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g6895.t1"/>
        </source>
    </evidence>
    <sequence length="467" mass="50435" checksum="77277B3072CF7A1D" modified="2023-02-22" version="1">MNFNLCNYDFISNKCVGKGEWVAGINPLTDSTNLNITCCYNEVLQSSTFLKSYNIGKGQMVKGGEIKISKKIYGFLYISNIMKIVNKDQSVYFKVFVNQLICNKIIHVKAAKIFSKHQKLKILGDSKKIPIDEIEDDDNSEVEFAVCDTERIPIEEVSTLEPTSTTETLPFDNSFNEDAEDTEVEFGGECFSEQGDEEGDVDGEVDGDTAGQSSVGNGGSGSGAGAGAGSGAGGGGGVGAGGGAGAGGYPSGASGAGGAGSCFSGDTMVKVLNGRRKRIDELKLGEWVSSAGNGKVGFNKVVSWLHRMPTIESEFLKLTLENGKTLKLTKKHLIYKVDCLANETFSKLSYLTIPAENMQISDCVLSLNHRRKLVPTRISLIEIIREKGIYAPLTESGNIIVNEIFASCSSEIENPLLTFVLPILNKYFEKIVETFGIYYNSIFESNKNEIELIPGVGSLINFAKIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZA71</accession>
    <name>A0A914ZA71_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZA71"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8687.t1">
        <property type="protein sequence ID" value="PSU_v2.g8687.t1"/>
        <property type="gene ID" value="PSU_v2.g8687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8687.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12140" checksum="7EE80489C6CAF83F" modified="2023-02-22" version="1">MGHSKASEFLLFGRKLSAQEAYERNLVNEVIPISTFFDECNRRIAEYAKLPPEALKINKQVLRRFHLKNLHKVNEHKCAVLRERWVSEECEQSLIAFANRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZCI9</accession>
    <name>A0A914ZCI9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADF-H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914ZCI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9641.t1">
        <property type="protein sequence ID" value="PSU_v2.g9641.t1"/>
        <property type="gene ID" value="PSU_v2.g9641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000026">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="7">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9641.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15981" checksum="D010D8B9189BB4D1" modified="2023-02-22" version="1">MSGSVTICQIPEDLKKQLRDFRFKHSASTNAIILKIDRNDHVMKVDAILDECSIEELQDELPDQQPRFVVISYEIKHSDGRVSFPLCLLFYSPFGCSTELQILYAGSRNHLVNACDLRKNAEVREIEEITKEFLDSKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZD26</accession>
    <name>A0A914ZD26_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Centrosomal protein CEP104 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZD26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g8160.t1">
        <property type="protein sequence ID" value="PSU_v2.g8160.t1"/>
        <property type="gene ID" value="PSU_v2.g8160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein CEP104 N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g8160.t1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9339" checksum="B834D05A91C7B4F3" modified="2023-02-22" version="1">MSSQLQFKVVSLSDQSNLQTGLLFDEEWVSKPNCQYPQSIVVKLEGRGFVDKIQVLCHRHFIPSKMDVYVSENSTSQFSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE38</accession>
    <name>A0A914ZE38_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A914ZE38"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9926.t1">
        <property type="protein sequence ID" value="PSU_v2.g9926.t1"/>
        <property type="gene ID" value="PSU_v2.g9926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000069">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF7">
        <property type="entry name" value="GLUTAMINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9926.t1"/>
        </source>
    </evidence>
    <sequence length="368" mass="40661" checksum="F1E08F0F44B14395" modified="2023-02-22" version="1">MLSQYRKIAGNEYVGFNNAVFLSERATADRNYALAYYMKENACFPPETTSLTDALDFYFQLCSLEATCESLSVMAATLANGGVCPLTEERCIDSRPCRDVLSLMYSCGMYDYSGQFSFHVGLPAKSGVSGAMIVVIPNLMGICLYSPPLDKLGNSCRGVAFCKEMISRFSFHNYDSLRNTETNNKFDPRKRHGDLEKDQVVALLFASKVGDLNTIRRIYLQGIDMEMADYDKRTALHLAASEGHMETVKFLINIARVKVDPRDRWNRIPMDDAITFGHPAIATLLEKAMILTDSGIQEANEQSPSSSSCASIKSGHLPRNISVATSDSSDDEESNDEFSLTSSNSKKILFTLGECAISPPTVVQTKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ZE49</accession>
    <name>A0A914ZE49_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914ZE49"/>
    <dbReference type="WBParaSite" id="PSU_v2.g9936.t1">
        <property type="protein sequence ID" value="PSU_v2.g9936.t1"/>
        <property type="gene ID" value="PSU_v2.g9936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH" evidence="1">
        <location>
            <begin position="66"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g9936.t1"/>
        </source>
    </evidence>
    <sequence length="242" mass="28289" checksum="E960B6E738FD3F06" modified="2023-02-22" version="1">MWNIFKPPRVLSEFPAIENAIQTNEKLAVFNKHPCNGDEIITKYFPNILVHAMRCSYEFKNITSKYKKEAVIIANSFGEYHLPAISEALEKTNFTKFYVFLQAGCLPYSKTMNYEHRHYNCDDWANISFDEFLDFVKPEIIILTARLSLFKEPLQSLPTSDLLKTDHATIEFHDKINNFAKHTKHLILMSPNPDVDVDNVYVKHLKHLVKFKWHSPLTIARALHQGFSLKKYVIPWKVKFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XS26</accession>
    <name>A0A914XS26_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XS26"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10793.t1">
        <property type="protein sequence ID" value="PSU_v2.g10793.t1"/>
        <property type="gene ID" value="PSU_v2.g10793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF551">
        <property type="entry name" value="RE08073P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10793.t1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28951" checksum="3F0E0C43675D758D" modified="2023-02-22" version="1">MLTFFAFVLAGLGTLGIGLWLRFDPAVSELMALRGDEENLNLICYLLIAAGAIMGFIGFLGCCGAWNQSQCMLITFFLVLIVVCCLEMACAIFAYTHQETIKKYIDNSMYDVVHVQYSRNDDYAQIFDRIQTEFQCCGVKSYRDWLHSSWGKEASSRAEIGIGTSAVGRVPSSCCNVEGLQSYPTTCGVTFDKLELHTYEEFLNINGCSDALYNSAYNNLQLVISLCVLICSCQILGMFLSVMLCCWVNTRKKAKNEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUD5</accession>
    <name>A0A914XUD5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XUD5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10858.t1">
        <property type="protein sequence ID" value="PSU_v2.g10858.t1"/>
        <property type="gene ID" value="PSU_v2.g10858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10858.t1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20704" checksum="7C5E89C854374F1C" modified="2023-02-22" version="1">MQLIKFEINANNNAQNNNNNNNPYDPRYNQGNNGQLPYGYNSNTNNPNYIADQNARMNTLGSLYGTPGLSGMGPEYNIRGPIVGGETSSTGGFGQSQQPLLPSAVFTAPEESQRGVVGQQPILPSNPAEFFRNQQQSLQNQGIQLQNQAQQLQNQAQTYGRDLSAATLSPNQQDQLRNQQSFLNNWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUE7</accession>
    <name>A0A914XUE7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPB6 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUE7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10591.t1">
        <property type="protein sequence ID" value="PSU_v2.g10591.t1"/>
        <property type="gene ID" value="PSU_v2.g10591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002207">
        <property type="entry name" value="PRK01099.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10591.t1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14698" checksum="CDE3569E4F0A747D" modified="2023-02-22" version="1">MADDEDYEAGDMDDGDYADDDEMPEDADLEAAEDEGERVQLLEAGGAIAAQERVTTPFMTKYERARVLGTRALQIAMGAPVMVEMEGETDPLEIARKELKEQKVPIIIRRYLPDGSFEDWGIEELHISDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XUY1</accession>
    <name>A0A914XUY1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XUY1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1035.t1">
        <property type="protein sequence ID" value="PSU_v2.g1035.t1"/>
        <property type="gene ID" value="PSU_v2.g1035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034913">
        <property type="entry name" value="mS27/PTCD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019266">
        <property type="entry name" value="Ribosomal_mS27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10037">
        <property type="entry name" value="MRP-S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1035.t1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19438" checksum="6893F7DAEE1AE00D" modified="2023-02-22" version="1">MNLTLRTYQILKSCRNFSTSSICRILSQEFQLNNEWQNRHAVLKELNLGGDYEWIAAVQKKFVGGGKASAVDVDAATCLSEEVDQLNDIVELVYKLRHTENAADLLPSTEYALYRLFLKYNAHEELFKVLNDPINYGVFPNYHVSALLLSHYIKAKNYSAAAKIASFTQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XV27</accession>
    <name>A0A914XV27_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XV27"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10398.t1">
        <property type="protein sequence ID" value="PSU_v2.g10398.t1"/>
        <property type="gene ID" value="PSU_v2.g10398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10398.t1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8939" checksum="C969A292C4BA55FE" modified="2023-02-22" version="1">MKQHSSSRASVSPQRASPKHGSTEYSTPVKNQEAASYSYRTPTNRQNHPEGWDHITWAPKPCRKAIRRMNFDGATAAVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVF5</accession>
    <name>A0A914XVF5_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A914XVF5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10956.t1">
        <property type="protein sequence ID" value="PSU_v2.g10956.t1"/>
        <property type="gene ID" value="PSU_v2.g10956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10956.t1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39995" checksum="BE30E1BB6AF81A6C" modified="2023-02-22" version="1">MESPAGVGFSYDSSGNTGTNDDEVATNNYNALVDFFTTKFPEYKNNEFYITGESYGGVYVPTLAVKVAADKTNFPHFKGVAIGNGIYSFSLNYNTMVPLFYYHGLVRQNLYDKVATECCKSNTYKCDYYTILNGFGECTSLVNELLDQGGDLDPYNLYSTCYLNSGSSSKRDFIRRMINHQSGLNLSKKVSGGAASGLPLCAQSNNTEIYLNRPDVRAALHIPSNVGHWTDCSNEVGYFYQRTHDDVSPEFKNLISHNLRLLTYNGDVDTVCNFALNKQFVAQLGQQLKPDSYDSAEWYYRAETPSVAGFVTRYTGNLDFVTVRGSGHFVPEDKPREALQLIYNFIHQRDYSLPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XVX3</accession>
    <name>A0A914XVX3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XVX3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10678.t1">
        <property type="protein sequence ID" value="PSU_v2.g10678.t1"/>
        <property type="gene ID" value="PSU_v2.g10678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10678.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="17020" checksum="4D48D1AB4A6C9151" modified="2023-02-22" version="1">MQEFLMIIENGKLEQVRLRDVRIFKDDENILVIEEIVELLPTAVDVAFNQVFPEMYTPETAQNLAFLDRSMIKFESFELAQIPQNFDISMFGLFLKANMIPKAFITLRLQQNIGEIFRNEFQHFCETIKLDWDPIYEAPRINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XX73</accession>
    <name>A0A914XX73_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein transport protein Sec61 subunit gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914XX73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g10350.t1">
        <property type="protein sequence ID" value="PSU_v2.g10350.t1"/>
        <property type="gene ID" value="PSU_v2.g10350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.820:FF:000001">
        <property type="entry name" value="Transport protein Sec61 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g10350.t1"/>
        </source>
    </evidence>
    <sequence length="69" mass="7677" checksum="5F41CB64CA879D8C" modified="2023-02-22" version="1">MEHVQSVVEPAKKFAKDSIRLVKKCTKPDRKEYQKIAFATAVGFAIMGFIGFFVKLIHIPINNIIVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XXK8</accession>
    <name>A0A914XXK8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XXK8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12684.t1">
        <property type="protein sequence ID" value="PSU_v2.g12684.t1"/>
        <property type="gene ID" value="PSU_v2.g12684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12684.t1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30440" checksum="95951CCCD1F5FDF6" modified="2023-02-22" version="1">MPNASVVIEMPKVEEMPKNGEFKNDEIVSSMPSSSDKMPTPADKDMPTPADNPVPSTPHSFIEMPKVEEAPPTEIQTSTSNDEMPPLQKPINEVEASIGFFGAGLFQDLKDSVASFLGSLKKSAKSTDNDNVVLQNEFVENISAITKPYLQISPNLESYATDKEANDQPLETVITDKCHPETSEMPVKNDAKIDGKLFEPMNSDSALSTDKNYGEKIEQSFEAPIFAEENNLPPPPPIFSENHFDTKSEIENAKVDAKKEIVDNFKDDAMVEKIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZG6</accession>
    <name>A0A914XZG6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZG6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g11923.t1">
        <property type="protein sequence ID" value="PSU_v2.g11923.t1"/>
        <property type="gene ID" value="PSU_v2.g11923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g11923.t1"/>
        </source>
    </evidence>
    <sequence length="307" mass="33701" checksum="BC9F8CF2BC0897EE" modified="2023-02-22" version="1">MGSYNTSGDGNHGYTDGNGGYNKAATRWHDSYDETADDEHILPIDANAAIPRSPMNNRFPRTILSPQQQTQAESTAAIPSSSPSSNNNNNAKNEGYISPRLMRRSISGSKSAAPLASADSGLGGSPVTNGASHNSASSTIMSHFKNLVNSFNIGSGSGHSRRRSLSRGISLDDHRSVTNLPQKPSSTSSSNHATPSIYRRSEEPKDRQTLEDEERELRRQRQRDRYHYKFDQGSTSPVVSSRNIIPSVQKTVIVNNDGAYRVESRLMNNGVVVESTPPPLEDKKSSQSCRRKRYQFLNFAPRAMSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914XZU7</accession>
    <name>A0A914XZU7_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914XZU7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12488.t1">
        <property type="protein sequence ID" value="PSU_v2.g12488.t1"/>
        <property type="gene ID" value="PSU_v2.g12488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12488.t1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9248" checksum="4B12C0A42BC110D5" modified="2023-02-22" version="1">MFLIKRFTSASPNPQYLFASSEQDGTWTTDGNDKIPSTAHLSWNGTLTFKNVTQSDVGSYEMPLEPSRLPMAQTVIYFELPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y070</accession>
    <name>A0A914Y070_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y070"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12860.t1">
        <property type="protein sequence ID" value="PSU_v2.g12860.t1"/>
        <property type="gene ID" value="PSU_v2.g12860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000387">
        <property type="entry name" value="H(+) MyoInositol coTransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12860.t1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29014" checksum="04660E71544FA920" modified="2023-02-22" version="1">MASVVGVIISLCLLGGAFLLIDKDSAKTLSNSTFVDKGVNTCGAHKNCDACVTDEKCGFCSEKGQNKVGWCLKHASGNHSDQYSENGICNSNSGSEMHQFGSKTYEFADVYCHTRWTVVPIILMVVYLSCFSSGYAPMPWVLNAEFFPLWSRSTCISITTFINWMFNLLISLTFLSLSQAATKAGTFFIYAGITVISLVFIYFFIPETKGCSIDEVELLFMDKKKRENDLRLRRLSGVSFDRQSPSAPRKGDFSRNASIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y188</accession>
    <name>A0A914Y188_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aminopeptidase N</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y188"/>
    <dbReference type="WBParaSite" id="PSU_v2.g12988.t1">
        <property type="protein sequence ID" value="PSU_v2.g12988.t1"/>
        <property type="gene ID" value="PSU_v2.g12988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036813370" evidence="9">
        <location>
            <begin position="23"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="10">
        <location>
            <begin position="279"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g12988.t1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45303" checksum="E500B64537547B6D" modified="2023-02-22" version="1">MEPYQFLAVLIITLFSCCCCNASLDSRNNNIRRLSGNLKPDFYTIRIHPFFDAPGVTFDPERNQTFDGDVTIFANVLHPTTTIILNAMNLTFPCANKNVIFSNTEMKAIKIINFLITPENQTITIDLERQLQQNESITIKLKYIGQIGDNTQFGLFKSTPDKEWATEDEYDDVVYVTQFETTGARYVFPSFDEPDYKATFQVTIVKPKQWVALSNTFNFTITDIGNGYEEVFFINTEIISTYLVAFGIGDLISVTGYTADYIVTRIWSTRSGKDLMAAALESAIKCTDAITKYTNFTLPLLKIDHLAVPWFGGAMENFGLIVYGRNLLLFNPKVEKLRQWLQRTSIICHELSHHWFGDMVTNKWWGDIFIHEGFADFFQNKAMALAYPKEKEYMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y235</accession>
    <name>A0A914Y235_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y235"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14241.t1">
        <property type="protein sequence ID" value="PSU_v2.g14241.t1"/>
        <property type="gene ID" value="PSU_v2.g14241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037663490" evidence="1">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14241.t1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11315" checksum="613A93221939BBE1" modified="2023-02-22" version="1">MLHKIEFLPIILILLSIAFFAQTYAASISNREAAVRSVLLRQFLDRYQPSLYHDHEVARRFDVNFDSEPQMSKRNNAELVNHIIKNFGAIDRLGDVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y2A2</accession>
    <name>A0A914Y2A2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y2A2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13583.t1">
        <property type="protein sequence ID" value="PSU_v2.g13583.t1"/>
        <property type="gene ID" value="PSU_v2.g13583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13583.t1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26307" checksum="A5EB17794391C11A" modified="2023-02-22" version="1">MACQNSQISCRNSDETSFILTHFGEYLTTMTFEIDFLEGTIARREIKFSVSEIFENEVSNVAINSVGVVAVIGGNKMLCTEFKSDDNEYTETWFDFDELSDLPQLNNYLQIHLYSVGNIFKCFILDETYKCYNINFSYKSENNRFTLLNAKKIPSFNPYKSREILITNEYFFVTDDSSNEMVTFVSRILSLSEAAYLTLQKHEKMSLMKLKKRMGFPKCLPITRAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y396</accession>
    <name>A0A914Y396_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y396"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13703.t1">
        <property type="protein sequence ID" value="PSU_v2.g13703.t1"/>
        <property type="gene ID" value="PSU_v2.g13703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="5">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13703.t1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19306" checksum="292189D23D775BB6" modified="2023-02-22" version="1">MNVAPKGSIAHVWKGDTMDDIMSEMYTVTSNGHHAILSSCWYLNYIKYGADWGYVDNDNNRLRGLYYECDPTGFGGTQAQMDLVLGGEAAMWGEFVDGTNITPRMWPRASAVAERLWSDPAQTYSADVAWPRLHEHRCRMMSRGYEAEPPNDPDYCPDYWDPQYPDMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y3S9</accession>
    <name>A0A914Y3S9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y3S9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14851.t1">
        <property type="protein sequence ID" value="PSU_v2.g14851.t1"/>
        <property type="gene ID" value="PSU_v2.g14851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000940">
        <property type="entry name" value="NNMT_TEMT_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053384">
        <property type="entry name" value="SAM-dep_methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041360">
        <property type="entry name" value="GntF_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867:SF38">
        <property type="entry name" value="NICOTINAMIDE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867">
        <property type="entry name" value="NNMT/PNMT/TEMT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01234">
        <property type="entry name" value="NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51681">
        <property type="entry name" value="SAM_MT_NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14851.t1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31291" checksum="EB9F3A7F8E299C37" modified="2023-02-22" version="1">MSEQKVKIFKPKDYETEFNPEAYLQFYYSSKALDDGTRLSLFALPMFAYLIQTKVPENLRQSLIDIGAGPTVYSAISFRDVVKRVYLTDYVEKSLTMLDDWLYQRTPFSWERAIHVIARTEGLHLKNDKEVIAVEEKARKLVENGGIFKADVHTENVLILNDQQQHPVDKTYDIAVSVFCLESACSTHDEYKQALKNIISLIRPGGYLILGSVIDDVIYNSGMSLVGDSKLFTLLDLDEEFIVKSMDENGMDLTTMKSYSLNNDGVAFFMIAKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y467</accession>
    <name>A0A914Y467_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9 10">U1 snRNP C</shortName>
            <shortName evidence="9 10">U1-C</shortName>
            <shortName evidence="9 10">U1C</shortName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914Y467"/>
    <dbReference type="WBParaSite" id="PSU_v2.g13570.t1">
        <property type="protein sequence ID" value="PSU_v2.g13570.t1"/>
        <property type="gene ID" value="PSU_v2.g13570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g13570.t1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15685" checksum="1469B5AFE04012D0" modified="2023-02-22" version="1">MPKYYCDYCDTFLTHDSPSVRKTHNGGRKHKENVRMYYQSWMEQQAQKLVDATARAFTQQQRLGGTGPRPQSQIPMPAPTAMPYALVQGAMPSMPRPGMPMGMGGMPGMPPLPSGPYPPPGAHAAFAGGIMPPLPSSIPFPQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y4M1</accession>
    <name>A0A914Y4M1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y4M1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15146.t1">
        <property type="protein sequence ID" value="PSU_v2.g15146.t1"/>
        <property type="gene ID" value="PSU_v2.g15146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="57"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15146.t1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18700" checksum="DDA079AEE1B27467" modified="2023-02-22" version="1">MPSSKQSRISLKSLKSSKSAKTQQVTTTEAELSTDRRVVVYDGPKHLKSGVKLKKNALYELLGVPPTATQNEIKKAYRQKALKLHPDKNVDVRNKEELNEKLGQINRAYKILSDPTKRKIYDQYGIDAVQTFEETEISPSWLWFVYTRLGRVCLFSMEICVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y5C5</accession>
    <name>A0A914Y5C5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y5C5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g14636.t1">
        <property type="protein sequence ID" value="PSU_v2.g14636.t1"/>
        <property type="gene ID" value="PSU_v2.g14636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g14636.t1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22186" checksum="6D86C4432B4E512A" modified="2023-02-22" version="1">MEDVVRIHLGDAFLFDAKNSFAHDTLPIGKSFEGVKPFCRNLLSSHGRLSTPGNTSTNFVETIEEESGEERSTSQAEIIRIHDVESDSHKIRPSTADVNTNKFMSPARIGRGESAPTLFKRSKSREKRSQMRKKKIDGDKESLDSHSIDDEIDDILSGSFSSISNSIGSNKHRSAKSRDSGFLGESGNFEADSKLDVLNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y7Y9</accession>
    <name>A0A914Y7Y9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y7Y9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15390.t1">
        <property type="protein sequence ID" value="PSU_v2.g15390.t1"/>
        <property type="gene ID" value="PSU_v2.g15390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15390.t1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40433" checksum="A410F1B4E0F54B50" modified="2023-02-22" version="1">MTLASKSQKPVIFIFASNEGIQRCKDYGHWSADGTFSIAPKKFAQLYLINALIDKSTVPCLFALLQRKNQQIYTHTIILDFEKAAANAFHSTWKETQPRLCLFHLSQSLMRRVKKEHLINLYTSNDDVKNTVRKLVSLAFLPVPLVSRGYNLVRGANDNKQLIPVLNYFKRSYVMKDIVKGRHTTPTFLPDKWNHHDSIIKDLSRSNNAIENYNGKLNRHFQSKHPKLSRLIKVLMAEDSLATEKMAEFEAHRSQGISLTGRKNIHKANDRDIRAQVEYFDLLYNAADLTLPSDEVILNHLNSLQRLLNRNRFDDLLKLDVDDEWEDDEDEVDIDLLTQPNDEEDDDAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y8G3</accession>
    <name>A0A914Y8G3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914Y8G3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1649.t1">
        <property type="protein sequence ID" value="PSU_v2.g1649.t1"/>
        <property type="gene ID" value="PSU_v2.g1649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF516">
        <property type="entry name" value="SERINE_THREONINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1649.t1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43055" checksum="743751EB330D0C91" modified="2023-02-22" version="1">MDNKTTATKLPSAESSEDKEDEEEDTSTTDEEEECENEVPESEVIENAFLDELIFRLMTAKSPQAQSPGSKKSVEATPIIQVQISSEEIIQLCDLAIQSFACQKALIRFEKKDLPLVIVGDLHGQFRDLRSILTRCGPPHKQSYLFLGDYVDRGIQGIEVATLLLALKCKYPSKVFMLRGNHEDGNTCMSYGFYDECLERFLLDEGGGDKIWLKFLSVFNWLPLAAIIDSTILAMHGGISPHLHTLDDIDRISRPAIVPPYGLLCDLVWADPDDRHDGWSLSPRGISFTFSSSIVESMCHKLGIELIVRAHQLTSEMIRSGHKFFANGRLVTIFSAPNYLNMRNDACVMKISKKLHCRFLILRTMRKAMRTRSLAHRQRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y971</accession>
    <name>A0A914Y971_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y971"/>
    <dbReference type="WBParaSite" id="PSU_v2.g1410.t1">
        <property type="protein sequence ID" value="PSU_v2.g1410.t1"/>
        <property type="gene ID" value="PSU_v2.g1410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g1410.t1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32568" checksum="EBC9EBD6CA37478E" modified="2023-02-22" version="1">MPSRRRKVRNVEQRRKMKLHNRRDDIPDCETLEIIEFDENCADPSFAELHSDSDSTDEKECKTLRTRSFKTPLLHDPETRVSFTDANNNDNYKDIKDRSFKSCVALSSSASRAASTARSKSDGASSAASTETRRKRRHRSKSRRHEKPSFLMKFAKSFLENLGQAITDFFMFLCSLLKIDAGNRTTPAGCFLLLVGTYFFISYIEVSFAGMIEILFEWLWPSIHISLRMIERFFKGIGNAFAGLDDLAESSYCDMASMWCDFFSLMCSSRCSFTKFALERIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Y9B9</accession>
    <name>A0A914Y9B9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Y9B9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15358.t1">
        <property type="protein sequence ID" value="PSU_v2.g15358.t1"/>
        <property type="gene ID" value="PSU_v2.g15358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="189"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15358.t1"/>
        </source>
    </evidence>
    <sequence length="544" mass="60949" checksum="D2BCA0F20A39DABF" modified="2023-02-22" version="1">MPKLPLISVRPKQAGLFPAEKVSIIPHQKVRMERMGPKLADTLHSYNAVLPHIRHQNISDIIRSLNLTEQNPILKAFGISVQSTFSVIPPSKMWRPAVQMGSTVAQPKDDGSFRVNSKYLVPATAGKWAVFYGDRGSRLDTVKTLVQRLCSEAAAKGMKLPPPTVIQSVDMANFMTKAFVNIKDLTGVSYILVIDPKNASATHNMVKLIENRYKIITQQLDSALVDKCVERNQRMTLENILNKMNLKFGGVNWAPKFEGEAAELALDKGTYVIGYQTAQPRMSTDRVYTEGEVKIVEPSVLSFTGNYSTNANLFVGNWLYQNAEHEMVNSQTLEDQMFHTLKLLAAKRPTNAKPKNVVVFRDGISEQHYDTFAGVEYQALKNACTRIDPKWKPKFILIVTTKEHDTRIFSRVNGRIENPPPGTMIQIRPGKELLATPQKALKGTVQPVKITLIKNESGVSFDGIMKFVHALSYTHQLTCSPTGLVEPIYQADILAKRGISSLLAFKEHFSKIVPRQPSLQYDIDGLNKRLTMKDSRLESIRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YAP0</accession>
    <name>A0A914YAP0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YAP0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g165.t1">
        <property type="protein sequence ID" value="PSU_v2.g165.t1"/>
        <property type="gene ID" value="PSU_v2.g165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g165.t1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21403" checksum="3E9ABB538F7F261D" modified="2023-02-22" version="1">MGDSAIANQLLNAAKVVEKQVDAEIERLDNLDDDDLEEIKRRRVAEMKANARKKQDQEAAGHGKVTELSDERDFFDAGKKSDKLVCHFFDPMNRRCEAVDWCLEKLSPAHYGTKFVKLNTEKVPFLIKRLNIRTIPNICVILDNKITNYLRIPDDGTTEHELLAHIEKWLLNENAVEKMILTKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YC13</accession>
    <name>A0A914YC13_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Charged multivesicular body protein 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YC13"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16828.t1">
        <property type="protein sequence ID" value="PSU_v2.g16828.t1"/>
        <property type="gene ID" value="PSU_v2.g16828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057471">
        <property type="entry name" value="CHMP7_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25239">
        <property type="entry name" value="WHD_CHMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25880">
        <property type="entry name" value="WHD_CHMP7_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHMP7 winged helix" evidence="5">
        <location>
            <begin position="131"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="217"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16828.t1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48912" checksum="52492E46E479BF86" modified="2023-02-22" version="1">MALTSSPYHPDWNKNETRGMFAYMKPRHVDPLQFDKKVAFWSQCISRFCETSKSCVIDFTELRQRFRREDLIAAPLESVMIEMYKKGDLQTEEDLLKKSQGWVSWVSSLVTGGNAPDVKTQSLIHLPTIAKLAVQLRNYHKELAEEYDDTPEIISYRELRNKTQHIIKDELSFDLVINHLKKCGDMSEGNSKGERILKFKDQQSRSPGKFTAADASVHDIRSAMRNLETEIRRLEEKEKQLKESAKQALQSKNRMKAKNIILKKKLIEKEMEKKDGQYQQLLNMLTKISETRQTAEVLDAYRLGNQAFKDALGRQGLSVDTIDKTIDSIHETMDDFKEINEAISTGFVPAEQRINDAELEDELNEMLEADQIADRNNSVKINKNIINISSLPEVPTFGLPSTSNASSLDSLSESLEYRMKRLREQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YCL0</accession>
    <name>A0A914YCL0_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YCL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17167.t1">
        <property type="protein sequence ID" value="PSU_v2.g17167.t1"/>
        <property type="gene ID" value="PSU_v2.g17167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17167.t1"/>
        </source>
    </evidence>
    <sequence length="179" mass="21160" checksum="B87D3E3F58C4FE59" modified="2023-02-22" version="1">MSKDFSKMAEKLGESGDSSHYKWFLDNSEGYRCICKRFHVVAMTKALWVYHLLLLITVTVTFFYHQLMYLWPSWVLVFLSGYAIYRQKSPWMWPFVIWVGLTIIMFVLLGAYLFFYSIFIRRTQKQESIFDSTTSSVLIHLGTLLFCLFHIWQFPVVSAAQRYFKNVDDVAEKVPYGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YDN5</accession>
    <name>A0A914YDN5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP synthase F0 subunit 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YDN5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18335.t1">
        <property type="protein sequence ID" value="PSU_v2.g18335.t1"/>
        <property type="gene ID" value="PSU_v2.g18335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18335.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13682" checksum="8C2B29D8B481BB77" modified="2023-02-22" version="1">MVNLDLPFTHRENANFIYGISYFYTVLVAALIWSIWKFVKSILSLKPKNIKSQVEKRLARHYAERRRYRQNLQQQQKNGSNQKISQTESQPPPKSHPENQAKKNGATKIEKKVVEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YEL1</accession>
    <name>A0A914YEL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YEL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g15824.t1">
        <property type="protein sequence ID" value="PSU_v2.g15824.t1"/>
        <property type="gene ID" value="PSU_v2.g15824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="58"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g15824.t1"/>
        </source>
    </evidence>
    <sequence length="492" mass="54844" checksum="242DAC9F2413D074" modified="2023-02-22" version="1">MGSTIHTATVNLPIFTETAIVATSDVEESDDSVATIKLNDSGNETDHQSLITAFPQKPVILGDPPMEVMIPQGEQLTLEFKVAAYPEATIQWYQNNFELKNGDGIRIERIGSNISRLTSTNPSEGLFRATATNKLGQTIYECRVFTEIDPVKERVIFTRKSLSKSPQPIYKLRRRGSLNQRSDLPKPPKIVTGFAPTHRVKVNEPLVLDVEAEAIPEADFQWRVNNFEIKPNKSIKIEKVDENRSRIVFLQPIEGRYDVVATNYLGKDNLSTKVIVDYAYGTDENNQFPIFLDALPLTTILASDTMEHVMVVVVRTSEPGSFRWFADGNELETNSQHEIISESLKSTLIIRSMVPNDTEYAVEFTNSLGIIHSKTTVMTSPKSRPKTPTDKPPRFIELLSSTAIAQGDILEARVTVGEDTEPCEFEWSLQGIKVAPEFVMSSTFESIIQIPNASKDMNGLLRVIAKNKLGQAESSMHFIVVDGKSLLNIIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFB2</accession>
    <name>A0A914YFB2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFB2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18132.t1">
        <property type="protein sequence ID" value="PSU_v2.g18132.t1"/>
        <property type="gene ID" value="PSU_v2.g18132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054333" evidence="1">
        <location>
            <begin position="27"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18132.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18457" checksum="9470971143E4A80E" modified="2023-02-22" version="1">MAVFLQRGFAILGLFLGLLIFGKVEAENFGCPPGWHFGSNCCNDNCYRVISVPSPNKARAIDDNYCTQLDKDAMPAVIKCEEENSFIPTLPKYHYLIQKTGLGIGIYVPTNVGWSKSNFRNRDGSKIEYTKWGYVSYILGGIREPGPGGGGEKTTLLLTYKRLFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YFL6</accession>
    <name>A0A914YFL6_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tubulin/FtsZ GTPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YFL6"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17551.t1">
        <property type="protein sequence ID" value="PSU_v2.g17551.t1"/>
        <property type="gene ID" value="PSU_v2.g17551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527">
        <property type="entry name" value="OS01G0282866 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36527:SF6">
        <property type="entry name" value="TUBULIN_FTSZ GTPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17551.t1"/>
        </source>
    </evidence>
    <sequence length="75" mass="8225" checksum="5A03CCDFE0FAE03F" modified="2023-02-22" version="1">MAPNGKMREVVSLHVGQAGVQIGNACWELYCLEHGIQPDGLMPADTTVGVEDASFNTFFSETQAGNFTIYRFVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG57</accession>
    <name>A0A914YG57_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG57"/>
    <dbReference type="WBParaSite" id="PSU_v2.g16326.t1">
        <property type="protein sequence ID" value="PSU_v2.g16326.t1"/>
        <property type="gene ID" value="PSU_v2.g16326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g16326.t1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43377" checksum="67AE611CC5B84BE4" modified="2023-02-22" version="1">MAILNAVNYFENDSRLFNIGLIIVPTGGGKSGIISLLPYALGSHKVMVLSPSKVITNQLITTFGGTANEESFYRKREILSSNEIHNFVPSTYMIKTAKYDVPQMANSELIIVNAQKFSRTAKPEIILNGEHGHISANIFNDFDTIIVDEAHRYPAKTWKDIVEIFKDKKIIFLTATPNPDVKCDIIYEIKREELERRHIIRSIEFIPLDIDNMNNLNDIDFHRFAMKIKAALQEQDMDAGKVYHKAMILVKKNKHYTMEMAAKFNALNDLDLKATFCTSDPESEKNLTLFDKKNKDIRIMVICQKLTEGYDNSNVSVCVILRNIGSSILFSQFVGRCIRISHDRENCETADVKAKVYGPQDMWDKYDKNATEDPDDNMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG59</accession>
    <name>A0A914YG59_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YG59"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18300.t1">
        <property type="protein sequence ID" value="PSU_v2.g18300.t1"/>
        <property type="gene ID" value="PSU_v2.g18300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18300.t1"/>
        </source>
    </evidence>
    <sequence length="117" mass="14566" checksum="0DDB2D9E6894C6C5" modified="2023-02-22" version="1">MFDLFERFKNGRMKEEKLEAFYNLYEDYFFEENMIKAEEMLWKIYSDKECLKMDKKGFVKKNLITLYKLPKRLEQIDQFKADGDYEKVVFIYQKIANEFFVTEEYENARDFYLKMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YG94</accession>
    <name>A0A914YG94_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YG94"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17791.t1">
        <property type="protein sequence ID" value="PSU_v2.g17791.t1"/>
        <property type="gene ID" value="PSU_v2.g17791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="14"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="151"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17791.t1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51399" checksum="71DCF1CB81E2D1CD" modified="2023-02-22" version="1">MKEYLKDEKNLECVLSFSFPKVFKKSYGIENRFIILPPTITLKGFGWNKFFKEPLSSESINASMEICGTKKSTQLFMDMVEINDSNIVAQFQTRKLFITKDEEKSMCRLSAYLHFPNGSTIKGIQSGHIKVMSKGSKKKKIDTATTNGSSSFIKNGSYIALFIRGPGTITRYLHCNSAGFCANLKQWSVYKIYSVDEQTGEHEFSYNSEKKFIYYQQNVLLVDTTTETSLPIMKIRKCGHTENKVYKFENNVNEPVCPFHMISFEYIDKNGNILYLATQNSDGIGWKSLTNPSKGINNEVKWNIITADRYLYRFYPLNGLEKISMLNFPIVLSINSTKLGDEWLEFEGRGFTKDIQIWFNTYPSCQTIYRSSSTITCVIPTLVSYYNHCSNLEITDTLTVPLYLVTFYGTIYPIPFLFAYNARKVGKIGHIIHVHEMDRNTVEQPVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIB4</accession>
    <name>A0A914YIB4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YIB4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18554.t1">
        <property type="protein sequence ID" value="PSU_v2.g18554.t1"/>
        <property type="gene ID" value="PSU_v2.g18554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18554.t1"/>
        </source>
    </evidence>
    <sequence length="159" mass="16237" checksum="90063A6F3A7F5611" modified="2023-02-22" version="1">MRLAGREQVDVATGGDTQRAIRAGGLGSGQIDIAVCPQHHVVASQQLAAAHGLITLADLQRTALAACIEVAAAAVHQHLAVDIAAGLQGHAAIGRDAGRSQVDVLARCQHHIAGALNRSHRVRGLAVAGVVAAVVVQRAALAQRLCAEGPGCRRLNQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIJ3</accession>
    <name>A0A914YIJ3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphate acetyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphotransacetylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YIJ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19322.t1">
        <property type="protein sequence ID" value="PSU_v2.g19322.t1"/>
        <property type="gene ID" value="PSU_v2.g19322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050500">
        <property type="entry name" value="Phos_Acetyltrans/Butyryltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004167">
        <property type="entry name" value="PRK05632.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007233">
        <property type="entry name" value="PRK09653.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43356">
        <property type="entry name" value="PHOSPHATE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43356:SF3">
        <property type="entry name" value="PHOSPHATE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphate acetyl/butaryl transferase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19322.t1"/>
        </source>
    </evidence>
    <sequence length="234" mass="24870" checksum="4C7D66377AA8E5EA" modified="2023-02-22" version="1">MTETVAREQLEDNVVLGTLMLEQDEVDGLVSGAVHTTANTIRPPLQLIKTAPGSSLVSSVFFMLLPEQVYVYGDCAINPDPTAEQLAEIAIQSADSAAAFGIEPRVAMLSYSTGTSGAGSDVEKVREATRLAQEKRPDLMIDGPLQYDAAVMADVAKSKAPNSPVAGRATVFIFPDLNTGNTTYKAVQRSADLISIGPMLQGMRKPVNDLSRGALVDDIVYTIALTAIQSAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIS3</accession>
    <name>A0A914YIS3_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPN-loop GTPase</fullName>
            <ecNumber evidence="9">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A914YIS3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g18724.t1">
        <property type="protein sequence ID" value="PSU_v2.g18724.t1"/>
        <property type="gene ID" value="PSU_v2.g18724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000888">
        <property type="entry name" value="GPN-loop GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g18724.t1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35995" checksum="EF1DFDB3C6A9F5D9" modified="2023-02-22" version="1">MADSSKPEPKRPAVLGNTVTRDQPPVVLVLGMAGSGKSSFVQALTAHLHKSRNFPYVINLDPAVRKVIFPANIDIRDTVDYKKVMHDYQLGPNGAIMTCLNLCCTRLQEMIGLVKKRSTEFPVCLIDAPGQIEAFTWSASGSIITDSFASTFPTVIAYVVDSARSTNPTTFMSNMLYACSILYRMKLPFFLVLNKSDIVDPAFLEKWMKDYEELGTSIEDARDAYINNLTHSLSLVLDEFYSTMTTVKVSSRTSEGMEDVMAAIEKCKEEYFEKYQPAFNELLKERLEKDVQQASDMLDKVNVTERNPQVVEEEEAMEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YIX1</accession>
    <name>A0A914YIX1_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A914YIX1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19462.t1">
        <property type="protein sequence ID" value="PSU_v2.g19462.t1"/>
        <property type="gene ID" value="PSU_v2.g19462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19462.t1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16463" checksum="C0B9542B928DED72" modified="2023-02-22" version="1">MDHDLFGLRPNHRFFEQHPTVNDALANLLASGMITVTEDVETFEEKAVIVKGGRRFACNELILGTGYTFSFPFLKPSNLIPIKEHQVTLYKFVFPINDPSLAVIGLIQPIGSVAPISEMQSRWIASIFASKLSLPSITDMIADIETKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJJ3</accession>
    <name>A0A914YJJ3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJJ3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19027.t1">
        <property type="protein sequence ID" value="PSU_v2.g19027.t1"/>
        <property type="gene ID" value="PSU_v2.g19027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19027.t1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7876" checksum="8005B530957FD168" modified="2023-02-22" version="1">MFAITDVASEADEIEVSQSVHEDIIAPSAQLNNQVVERESDAVAARTIIVVESLTVQFEENKEEECEKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YJL1</accession>
    <name>A0A914YJL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YJL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g175.t1">
        <property type="protein sequence ID" value="PSU_v2.g175.t1"/>
        <property type="gene ID" value="PSU_v2.g175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037955244" evidence="2">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g175.t1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28446" checksum="69D63D4AD1C8885C" modified="2023-02-22" version="1">MQVLFRFVFFFVFVKTIATQNYDNEDYGINDYETAVAYDNPNQYYEDENNDYSYDQYPTNAQNIDYNEYSPDSQYYGDDSINNDYKYPSYPDYIQEEYYSKNSNNRNPEKQSLHQPLSPQNQSPGHRKPKEFRESFGKDKNDILEILKKILEAQKGVKGEHGKTKESKKSDLSDQNLNIKDLLQYLKEIANGKKPNFGEIVSKFGKSGLKEIQELLENNGFGGENGEAVGGSIAKAGFGFIQNLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKD7</accession>
    <name>A0A914YKD7_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A914YKD7"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19803.t1">
        <property type="protein sequence ID" value="PSU_v2.g19803.t1"/>
        <property type="gene ID" value="PSU_v2.g19803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF57">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19803.t1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16282" checksum="A5D7DD96B08FAC9B" modified="2023-02-22" version="1">MIKDHLAKISNCHLAHSDLHSLEHPEVIEMAKNADLAVNYFKSGIPADDIEEEDMCDWYPDFMDKEHLPSYTSPRLLGKLHRKCNRFWNVTMNIVNENQYSKTPIDPVYDIYGWEEYRDEAAGLYKTYNSEIEVKSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKR3</accession>
    <name>A0A914YKR3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YKR3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g17913.t1">
        <property type="protein sequence ID" value="PSU_v2.g17913.t1"/>
        <property type="gene ID" value="PSU_v2.g17913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g17913.t1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22602" checksum="D549324EC8F4CCB1" modified="2023-02-22" version="1">MMFQFLKLVKSEDYGIGTFAERIEEYVERFGHEIDEEQIIYSSFGLLSDAEKDVIIDKSNKILAILKPYIDKRFEIGILTDVIDARSDVVNPEDVKKLGIAAIPSTSHSVSLFYHHRLFLTDIMSTLSSPPTKLSEWEKLIDKWIKIIDILVSNEYPCSIEEHIHGQRIIDRITETCFEYLNSLFTKLGKFFTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YKW9</accession>
    <name>A0A914YKW9_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cleavage/polyadenylation specificity factor A subunit C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YKW9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g19523.t1">
        <property type="protein sequence ID" value="PSU_v2.g19523.t1"/>
        <property type="gene ID" value="PSU_v2.g19523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000002">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g19523.t1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13519" checksum="FEDD15625DD4E819" modified="2023-02-22" version="1">MITTLQKTNLVPGAEDALVYTTITGAIGMFVPFVSRDEYELFQTLEMHMRVEFPPLCGRDHLAYRSFYAPIKNVVDGDMCEQYGMVEALKQREIGENLGRKATEVAKKLEDMRTRYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YL89</accession>
    <name>A0A914YL89_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM39 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YL89"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2031.t1">
        <property type="protein sequence ID" value="PSU_v2.g2031.t1"/>
        <property type="gene ID" value="PSU_v2.g2031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019397">
        <property type="entry name" value="Uncharacterised_TMEM39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995:SF4">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10271">
        <property type="entry name" value="Tmp39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2031.t1"/>
        </source>
    </evidence>
    <sequence length="89" mass="10498" checksum="0D04D4553D90C966" modified="2023-02-22" version="1">MGNDPVRFVTILCIFEFSLILFQFWLLVLTTDWQHIVTLVLLMFANYLLLGKLFKDRIVIGRIVKPTPEDNSLWYQLLEEQRSRRPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLE4</accession>
    <name>A0A914YLE4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YLE4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20175.t1">
        <property type="protein sequence ID" value="PSU_v2.g20175.t1"/>
        <property type="gene ID" value="PSU_v2.g20175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="74"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20175.t1"/>
        </source>
    </evidence>
    <sequence length="561" mass="62548" checksum="95C5BC2687A1F69E" modified="2023-02-22" version="1">MIFKYLLNKPWGAIASGQRRIEQKQLKRSEGFDYFHQRCRSMDNERREYILAMGYEELRQGLQNNSLTPTEVHQAYGWKILEVNDKINCVAEMITESFTMAAEVERLYHNKPNKPAFYGIPVSVKGNFFMPGYDCTIGFSKFIGMPKDSQCSLISTLIELGAIPICLTNVPQALLSYACSNPVYGTTENPLAHGMTPGGSSGGEAALVAAGGIPFGTGSDVAGSLRIPAVMCGIVSMKPSEARLLITNSHGGFPGKCRLGLSFGFFTHNVGELINIFDLYLNSEEHLKCSPRSIPMPFDMSKVHKKEKLRIGYFSDIGFLPPVPAAKRALRHAVKMLEVDGHEVIQFDIPHPQLMAELVLKNILPDGGVYMKELFSGDIVDDYMKQFLLLLKIPDSIRKIASYAIQYVCPQLATMCRIGMNNIPQLRYMQEQTDDYAREWYEQWNNLNLDAMICPSFPVTQLPHSYPSKLGACAVYTGLFNMLDCPAGIVPVDKITDQDIKDLNNDNIFPVGLNPILKDMRSGCSKDEGLPVSVQVVTLPFREELCLHVMQIVEALAAKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLM8</accession>
    <name>A0A914YLM8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLM8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20465.t1">
        <property type="protein sequence ID" value="PSU_v2.g20465.t1"/>
        <property type="gene ID" value="PSU_v2.g20465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20465.t1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23678" checksum="40F094DDC5229883" modified="2023-02-22" version="1">MFEEVFYQAIPKENELNAVFMIRYVIDMLRSQKVQHRQGVLRLISELRKIIENLYEIIIHKPDVFSRPQFINDNIDDEDYRAQFLEYLHFDIPIKPKRIHVYPRATNSIKVLTEFTPMTHLMILLFKDEVTDEISHLLRAFTLHLNYQLPRTNVDPEYSAMFQETQLKILNFVCLIVKPNQNVCLRCLSNNFITVENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLP8</accession>
    <name>A0A914YLP8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLP8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20487.t1">
        <property type="protein sequence ID" value="PSU_v2.g20487.t1"/>
        <property type="gene ID" value="PSU_v2.g20487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20487.t1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25660" checksum="D81A6C851DE40795" modified="2023-02-22" version="1">MEDSFRTMYSYPKTMRSDCAMQIENTLLVIGNQGPAMLALALGFERFCAIRFPASYRHFKEKMFHILLIFAAIICITSVCVALYTGLIIEKDLAASLPCTLSNAFGFTYTTFNYFFTSFGHTAGFIFNFAAFWIIQSFKNKGRNSQVIAKEIEQIRLMHFISICSLIMVVIPNMFLYATRFNFFTLDYVILGWLNCAFVSRSAFSLHLLGFRSPKFRQRVSEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLU1</accession>
    <name>A0A914YLU1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLU1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21295.t1">
        <property type="protein sequence ID" value="PSU_v2.g21295.t1"/>
        <property type="gene ID" value="PSU_v2.g21295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21295.t1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17670" checksum="56C48E8150744889" modified="2023-02-22" version="1">MASYTAVGGGQTPSMTVNFKMNITTYGPHNGIFITSGIQQGTSTAGFFAAHTTPNGTVFAAPSIPAIQEIPSSLRGSSISVGGGAPLGGSGRTTIVKGDKFDLSRSRSTSRSRPSSPLINFYGGGRDSPPDEFIEPQNVKLNVFNEVSKKSIFCDSYFLFSTFNIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YLV4</accession>
    <name>A0A914YLV4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YLV4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20548.t1">
        <property type="protein sequence ID" value="PSU_v2.g20548.t1"/>
        <property type="gene ID" value="PSU_v2.g20548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20548.t1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11616" checksum="3E3D1F631E898C26" modified="2023-02-22" version="1">MTTFIFLEAISAYIPQSTEYRTTSENFVTTTAASGAPFNENERRFHLTGERDFSREPSFLHHSAAGLRDLIPPPVLHSTPERNPDGINNYGYDVHEVHTSGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YM96</accession>
    <name>A0A914YM96_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YM96"/>
    <dbReference type="WBParaSite" id="PSU_v2.g20045.t1">
        <property type="protein sequence ID" value="PSU_v2.g20045.t1"/>
        <property type="gene ID" value="PSU_v2.g20045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g20045.t1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14222" checksum="CC0156BD9F647429" modified="2023-02-22" version="1">MKFTPVNDLICGDEGRCEPGFQCSRPMEFDGPYLCLQKIFLDHDFLFPFTTPSPPVTSTTASLPGVPSTEPAVVPASPVHHYLVVTLQKGSSTRPLFPISTSNNSTISCCSNRYSHFTSRHNPFSSHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YMC3</accession>
    <name>A0A914YMC3_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YMC3"/>
    <dbReference type="WBParaSite" id="PSU_v2.g21489.t1">
        <property type="protein sequence ID" value="PSU_v2.g21489.t1"/>
        <property type="gene ID" value="PSU_v2.g21489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g21489.t1"/>
        </source>
    </evidence>
    <sequence length="345" mass="35007" checksum="73F93B4BE2B76094" modified="2023-02-22" version="1">MPPSVTRTLPHTDQPLVLGLEVLTTDAEVAVGVGHHRVGAGVGVLGALDVGFLAQLAAVAADGDHEVLVRGVGHAAFHVHALAAGRVLVTGAGHHRDGVVEVVAQVAEAMQAPVGRVAVLQAVGQGVLDIAHAVELLDVRDPRHVGGTDAQVEGRVEAALHVGLLDEQFGVADGRAVLEVGGQVGRPDVVELVVDGQVEALDVQTGAAGGGVLAVAGLVDVGQVEEHATADLVVIDQLGQLVDAGLGLLCTFPGLRLAPANRSATAGPGPAAQRSVPEAVQLCLGYARVGGGCEGVGGNQTEACNDRGGEQMGTHFGFLQRVGMAWAERHAGRPVKRFANVPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YN11</accession>
    <name>A0A914YN11_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YN11"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2275.t1">
        <property type="protein sequence ID" value="PSU_v2.g2275.t1"/>
        <property type="gene ID" value="PSU_v2.g2275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037663657" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2275.t1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12164" checksum="3A29C1193ADA629F" modified="2023-02-22" version="1">MKLIILFILINAAFLNFAFARSLQDLYEAMEVKLFDDIRQKDFVGAGAPPAFIEVKPQPLILPPKIGFGKLVHGKNVPFQLLGSSAKDAELIAKPKTVSTIMNRIRAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YNB1</accession>
    <name>A0A914YNB1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. MPPE1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YNB1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2045.t1">
        <property type="protein sequence ID" value="PSU_v2.g2045.t1"/>
        <property type="gene ID" value="PSU_v2.g2045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF0">
        <property type="entry name" value="METALLOPHOSPHOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="51"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2045.t1"/>
        </source>
    </evidence>
    <sequence length="378" mass="44864" checksum="8AC7BBD34937EA3C" modified="2023-02-22" version="1">MIKKLFKMRKILIPFLPLIFAFIFNEYFIYHFVIGRCSWPKIKENENEFTNVMILADTHLLGIRHGHWFDKLRREWQMRRSFQTAISWLSPDAVFFLGDLFDEGQWADDQQFDIYANRFDQLFSVPETTKRFVAVGNHDVGFHYALMPHHLDRFSRRFNIDPTVEYVNIGGNHFIIVNSMAMEQDGCKLCHQAEETIKALKGKFDCALLEDCEEKLSGGYSRPILMQHFPLFRKNDEICEFETDLAPPSLRSQIFREKWECISKESTDFLVKSLRPRAVFGGHSHFTCSKFWEAPYNFWEYTISSFSWRNNRWPSFLLLKVSPKQLKVQKCHLPCEHTVIWIYALATLLSISLIFINFFLWWSNNRTISFRRVSTKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YPH5</accession>
    <name>A0A914YPH5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YPH5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2736.t1">
        <property type="protein sequence ID" value="PSU_v2.g2736.t1"/>
        <property type="gene ID" value="PSU_v2.g2736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2736.t1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20971" checksum="87CDBDD3F1B4BF18" modified="2023-02-22" version="1">MLAMERRIDDTTAKHHTEMEHGYKTRWRIYLTYTFGNDSFESNNPNYPIRYGLYRTSLLHKDVEPLDAQMKKICEEIIESGRCLQQLNNFCENPAKAFQDTQSYQQGESTALPQSWNNPNVAYAVQVYRRQQFNIRKNMLKQHFEADHHIKNATAKKLCELADDHQLKTSIEVIQIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YRR8</accession>
    <name>A0A914YRR8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NR LBD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YRR8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2707.t1">
        <property type="protein sequence ID" value="PSU_v2.g2707.t1"/>
        <property type="gene ID" value="PSU_v2.g2707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2707.t1"/>
        </source>
    </evidence>
    <sequence length="417" mass="46475" checksum="4630850159C37D67" modified="2023-02-22" version="1">MKPEAIQNERDRIGSTKRSRKRALPNHLASNSGYPMSSTRSSISASSDENTNDNGDNSRSSLSPHQQQQLQQQQQTASSTSQQQQQQQNLTNEASKRLIEMLMDIEIRLTSTLSEDDKLTARQRIINLIISWSNMLHPLPDLQFNDKVNLLKHCTSAFGLLQTLQRSMSSAHIVLPNETYLSLTTTYAPEVSTIVARILDELLTPLRRINVERSEFACVKAFILLQPDICGLSVTTRDRIRESRDSFTRALFTHMSHNHSISDAAVRLSSLQMILPSLFSISKEICENATLGTLFGLIEAPQPILPVTTLPSTSGTPGSLTSGQPIIPTQSSMTIPTTLPSSRPDSKENINLLAQFNLSNMLNINRPLENPQQPQFNLPVSLANFTGFNFGSVSFFYSRLKVLEDFGKSFGTFCQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS18</accession>
    <name>A0A914YS18_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YS18"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2804.t1">
        <property type="protein sequence ID" value="PSU_v2.g2804.t1"/>
        <property type="gene ID" value="PSU_v2.g2804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="634"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2804.t1"/>
        </source>
    </evidence>
    <sequence length="942" mass="106826" checksum="88BACB9C0D75BA96" modified="2023-02-22" version="1">MPPENDSGQIEVGDYKGLQYSPEELKLLITSSIHKGSTSEALIKHLGNIGDGPTKFVKVKFDEELLKICKAKLKDIMAELVSAGNTKFIFEARKEIKLDSTFFTHIIRSLDRNGIHLEDEKLAYWPEDLQKFYYFLESRFIPTGPEETLKNLIVEWFEAGEMSLEIWKQWVSWFSNGISLKTLKSIKWSKASQKDTVRPKFLKTLATIPTDDFLEKEVLRKILTLYLEEPKVEMDIDEYVDENGYKNKVETKAINVIGRTIFLSTIKSKLESLIKEKNIEEIDIISKNTFHIDDSLEGHLWNGKNISIVADKVNVWDEQIFDVSGQGYSSTPGRKARDGGTGENGFNGRDGKSGLSSGNIAIITEDMTNSDNLTVKLIGGDGEDAESGGNGGDGKDGIGVTLDELKDIAIKYVSLWDTIWSKWTSYHPTGWTKTWEASNFISSYIWYEFEDVHGRKLHYTFGADKGFLYNWYELVIWIKGTDGTPGGIGGLNGKGGEGGNPGECTIINPTTGWEYSINKVRRNGRNGMDGKVGECGKSGYNGNHMALIDRSAKGSNLHYYGDAKPCRLTQSWSCDNTKYSRINRYYYIVKDDASCYGSFQNGDIPTSGLRQQQQQKKEERSSEAQTTMKKSIVLNKVMQKAQEQKAKMDSAMSAAAASIKSKITQKLNLEEEVEEEESTEQEQEVVIVKEVNEDQLDISRTKARKCKLSPLQFVNKIKQKRSFEGACLLAQEIVDYFLIEFNDDHLESIKFSILKKCGRFREIMENRFQRMIVSAVQAKSPDGLTYFELQTLAKNASSKRILKKNVTKFRQTVLQFPLTCQTAALSIEEKLIKNGNILEKVKFCIPESDKLWFHDISRDAIEDIVKLFFKDYRFNKVSQEMLLKIFHAHSNFATKYSTLFQCFENSSVKWADSESWEGFKPTLTEGNANIKKIITTIAADKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YS73</accession>
    <name>A0A914YS73_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="3">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A914YS73"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2865.t1">
        <property type="protein sequence ID" value="PSU_v2.g2865.t1"/>
        <property type="gene ID" value="PSU_v2.g2865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF71">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036987533" description="receptor protein serine/threonine kinase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="180"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2865.t1"/>
        </source>
    </evidence>
    <sequence length="554" mass="63261" checksum="35FA94D320961AD3" modified="2023-02-22" version="1">MLLSLLTIGCLFLHSIVSLNTETFESEEAENSTQKIFHFNRHDILRKNNKSAENLCFCSLGPDGCDYKDQICLKHVNAACYHSVKLVYNDELSRMERVHYYGSFESDQINDRYFMFIIFAFIGVCIGVTLIVSFIWKAYVRKKKRLMERKSSISSMNSDSSGGASIDYAPLNPRTVAQYLTFINEVARGRYGCVQKALFRTREVAVKTFYTNEEESWRNEKDIYETQMLNHENILQFVAADICSVDSITQMLLITDYHPLGSLYDYLRAHENLDLDEALQLALTSVCGLEHLHTKVQGTGNKLKPEIAHRDIKSKNIIVKRKNVCCIADFGLAVRMEKGQLIPAHLNPQSGTRRYMSPEVLRGSINIRNFEEFIKSDIYSLGLVFWEIFNRVNNDPNKHRRVSSNSSNESGITRSQSSQCITGESIPLVTAPIKDETTHIIKPFRLSYDEYAPNDPSIEQMRNVVCELKLRPTFPEKWTENENGPYASIAKLIDEMWTDNLKSRHTALKIKMELDKIIQIILQSDPTRASSIHFPKFQSPPSSSGYGSGSRPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSC5</accession>
    <name>A0A914YSC5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSC5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g2916.t1">
        <property type="protein sequence ID" value="PSU_v2.g2916.t1"/>
        <property type="gene ID" value="PSU_v2.g2916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037342888" evidence="3">
        <location>
            <begin position="22"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g2916.t1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39916" checksum="02AD470D0CC59BF0" modified="2023-02-22" version="1">MNCCCFKILFAAFLLLNSANFQENFSNNVQFLDGKIHKELADEMLSDDVGIQQGNDVKIIREGPINLTLTFNKLEFEVCKDDCIGESNICYESLNGLDDTNAVGSCTGFSSSCEFKVKNDEKHNTIVIGEVTHVRTNLFSGCLTSSMKYPLVEVLKNLEFESCDPKVNPADKMIKLQVIHLSSCPIIVKNAEIHVPEVASTKPPPTQNPNDTSLTASFPWWGILIIVFAFVFAGIGIAFVVYCIFKKRQTSKHVSPPDANIKPTVSNTNVATFESPSGRKHDFTKFELLQKSKKTQRKKAKKQTTQEPTTTEIAPAPVVNVPNAPILPPPAQIPSNVTSNNYYPPISRSIPRSLKQKFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YSM2</accession>
    <name>A0A914YSM2_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YSM2"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3157.t1">
        <property type="protein sequence ID" value="PSU_v2.g3157.t1"/>
        <property type="gene ID" value="PSU_v2.g3157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31024:SF12">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="78"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3157.t1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18290" checksum="51756DB6C6EFEA67" modified="2023-02-22" version="1">MPIVTQIRNSGVKIISVGLNQTTEIFSDISDRLFLSSTYNISANISNEIIELICPIPPPPEEPMGTLCSQNSQNAWLDVAVIIDISNAMSTRYLSEAAGQLDTLFRLFTIGQQPKHSTRVGIITFGSDATVRESLINTTNFDNLQTAFFDITNFYDPNDKGGNILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUA8</accession>
    <name>A0A914YUA8_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YUA8"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3574.t1">
        <property type="protein sequence ID" value="PSU_v2.g3574.t1"/>
        <property type="gene ID" value="PSU_v2.g3574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3574.t1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18436" checksum="8F61827E42F55996" modified="2023-02-22" version="1">MSWYSSSGPYTPVKRRSAKVEPLTPDQVKYILENPYPTGYTYANSSSYSVNKPRDYIHPNLSRPALSSIVKDTVSWVFSTLFLYTPLYPLYLGYQKGTSLFGYITIVTNFVKDAFVIFFKSIQDFFYTNGYMIMQLKDDIKTLFEGELGRHKWYELFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YUI9</accession>
    <name>A0A914YUI9_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A914YUI9"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3805.t1">
        <property type="protein sequence ID" value="PSU_v2.g3805.t1"/>
        <property type="gene ID" value="PSU_v2.g3805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
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    <sequence length="258" mass="28796" checksum="E0D2F82CDD675F0E" modified="2023-02-22" version="1">MAPPFAAEKASPDIQLDQAQRSAGYGDEALRRGVRAIFLGPPGSGKGTQAAKFAHNYCICHLSTGDLLRAEIQNKTDLGKRIDSTIKEGKLVSDGTVCELIDTNLNKPECKHGFILDGFPRTTGQAQELDKLLEKRKSPLDTVIEFGIDDSLLVRRITGRLFHISSGRSYHEEFNPPKKSMIDDVTGEPLTRRPDDNADALKKRLELYHKQTLPLVQYYSKRGIHTALDASKPMEEVSKKIDHIFAKFAKNKDRAFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY04</accession>
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        <name type="scientific">Panagrolaimus superbus</name>
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    <sequence length="379" mass="43961" checksum="A9476090B9A4E1BD" modified="2023-02-22" version="1">MIFTGADADTANEIAKIIGKNKEREGIIEYYSAFLKKYHNTIKEVEDEKYSAPKPKKSKKEKFDPINIVAANRLFISDKSKLLDLFVKEMHEKFNGHFQQLDFTNTDLSVSTINNYVCEETKGKIDKFFTNEDLDKRTTLIVLNVVYFMANWATKFQPRHEGTFYSEIPRKTDMMTGNFYDLNYTNSKDWHAIGIPYRGGKTCMYIVLPKEKNGLEKVMQSMDHKMFMKFTKENFLADAKIDVTIPVFEISDRYDLCNILSQMGIRQMFHKSEANFSRMFKDPHRHFVNKAIHMATIKVDENGTEATAATSFGMMPRSAAPPKKFVANHLFIYFIVKLETKEKNIEAFETKTDNKLKEDAEENIDELVPKEILFAGIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YY19</accession>
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        <recommendedName>
            <fullName evidence="3">IFT121 second beta-propeller domain-containing protein</fullName>
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        <name type="scientific">Panagrolaimus superbus</name>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="LD29485P"/>
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    </dbReference>
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        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g4848.t1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17334" checksum="D0046E1E4E3421CD" modified="2023-02-22" version="1">MSLNCSSTRLAIISTNNIFKLFDIRDNGTQVVPSFEKKDIWDMKWDTDKEDTIAIMEKSRLLVVQGIIAADPVPNHGYICSFRDLTVRTIQMQYVMQNPKDFDRGLISDIEVKVMMTFFRTLRKAKELLDAGKISEANVFIEQNSHPMLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYB5</accession>
    <name>A0A914YYB5_9BILA</name>
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        <submittedName>
            <fullName evidence="12">SAM domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYB5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3054.t1">
        <property type="protein sequence ID" value="PSU_v2.g3054.t1"/>
        <property type="gene ID" value="PSU_v2.g3054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09515">
        <property type="entry name" value="SAM_SGMS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3054.t1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47008" checksum="AE1B6268F2F421BF" modified="2023-02-22" version="1">MVVNANIITSSTPNSLIVEKQLKWSHRPIEEWSNQDVHRWLIDNGFKNIADEIAYNQKVDGSALLLITEDDLRQPPLSLSYLGDIKRLGKAIQQLKTYETDLSIPNASLPALNASLDDPLPNENEQNVVSQRSLTQLSSHTSSDGLKTFKLITREELIKHIESPDTKAKSLIKLALAFVYCSLSLLVTAITMVYVHDRVPDMKTYPPLPDLVLDNLPLIPWAFEVCEMIGVALAMIWFTILFFHKERVVLMRRMFSLVGTVFLLRCVTMMITSLSVPGIHLSCRAKSYGSWNAKMQQAFHIWSRLGMSIQGVRSCGDYMFSGHTTAITLLNHFITEYTPDSWHFLHTSTWVMNFFGIFFILAGHEHYSIDVFIAFYISSRMFLYYHTYAYNYNNLTATDSRMRLWFPLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYI0</accession>
    <name>A0A914YYI0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="32 33">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="26">Cell membrane</location>
            <topology evidence="26">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Invadopodium membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 26">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYI0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g3108.t1">
        <property type="protein sequence ID" value="PSU_v2.g3108.t1"/>
        <property type="gene ID" value="PSU_v2.g3108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000043">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000075">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000155">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07965">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
        <property type="entry name" value="Integrin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69687">
        <property type="entry name" value="Integrin beta tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="16 26" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="17" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="24" id="KW-0966">Cell projection</keyword>
    <keyword evidence="21 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19 26" id="KW-0401">Integrin</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0675">Receptor</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 28" id="KW-0732">Signal</keyword>
    <keyword evidence="10 26 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036848628" description="Integrin beta" evidence="28">
        <location>
            <begin position="21"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="29">
        <location>
            <begin position="52"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit tail" evidence="31">
        <location>
            <begin position="653"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit cytoplasmic" evidence="30">
        <location>
            <begin position="767"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="216"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="472"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="495"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="540"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="564"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="583"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="585"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="601"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="622"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="624"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="646"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="659"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR002512-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM01242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g3108.t1"/>
        </source>
    </evidence>
    <sequence length="818" mass="91643" checksum="C333BA14172F9B74" modified="2023-02-22" version="1">MRQWVFIFLFIAIISCSVFAATWEEDEATSDGEVLESSTDFPCHSLSPENYTCSACIQFHDTCAWCADWGFNNQTQFSRCDSRANLLENGCPQNEVVFPKTTIRNIENEDLRDGDENIEDIQIRPQEVDIQIRPKSRARFFVTFRQAANYPVDLYYLMDLSYSMKDDKEKLSQLGDLLAERMKQITRNFRLGFGSFIDKKVMPFVDPRKEKQVSPCSEGCAPTYGFRNQMGLTIDTNKFAKEVDKALISGNLDAPEGGFDAIMQAISCNDSIGWRDRSRKMIVFSTDAGFHYAGDGRLAGIVTPNDGQCHLDREGYYTKSIEQDYPSIALLHQKIKEKKVNMIFAVTQNNRQLYDQLSNALPDVSSSVGVLANDSSNIVQLVEQEYEKIAEKIIMVDNANSSMGLKLSYRSRCLVGEELVDTNVCDGIKVNGQVGFEVTLEATHCVKERDFTLKIGPSGLDDSLRLNVHVICDCDCEREVVYNAPECHGRGTLACGICQCAPGFVGKHCECDSGGETAFALESKCRKDNSSLICSGRGTCECGVCKCFQRTNPLEQVTGQFCECDNFNCPRHDRKLCGGHGKCNCGVCECEPGYTGRACECPTSTDSCLSKNGKICNGHGDCICGKCHCHTDEDGSRYSGPFCDICPTCPSKCVEYKPCVMCQQWGTGIYNESKCAECPFDVIPVKELPVLNISENAEDETWKECQFVDPSDDCTFYFLYYYDGRNNLTVWVKEDKDCPAPLPVLVIVLIVIAGIVILGLLLLCLWKILTMIYDRREYAKFEKERLNARWEANENPIYKQATTTFKNPVYAGEAAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YYL1</accession>
    <name>A0A914YYL1_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nematode receptor-like protein sre family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914YYL1"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5593.t1">
        <property type="protein sequence ID" value="PSU_v2.g5593.t1"/>
        <property type="gene ID" value="PSU_v2.g5593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004151">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052854">
        <property type="entry name" value="Serpentine_rcpt_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47518">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS EPSILON-13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47518:SF9">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03125">
        <property type="entry name" value="Sre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5593.t1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18023" checksum="B23FCCBE5CF62E45" modified="2023-02-22" version="1">MYFESMSDGSVYTLSQRYQLCENIRTSNLLRKCSVVSSICIPVGIALFAAEVLFTSFKYKLLFKICFEFSAAIFGLLFIASALKTNELWCRNFYNILCCKYRKKCRTLPYIQSRENISSVYNAKIFRTSTGKRMIFDTNLESGLYFSQLQNSWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZ35</accession>
    <name>A0A914YZ35_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914YZ35"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5369.t1">
        <property type="protein sequence ID" value="PSU_v2.g5369.t1"/>
        <property type="gene ID" value="PSU_v2.g5369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5369.t1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14493" checksum="EEF9547707BE83E9" modified="2023-02-22" version="1">MPVPALLEILKTLSYKELGEMRRIHPHWDELCGQLLNSGYYTLINKADVLLQDCQRRVYTEKELQTAITALTNLQVHVLNPVDMMRAPMDEGVLCFPYGHLLDKAFELIDRIERVVQGKDDPEVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914YZL0</accession>
    <name>A0A914YZL0_9BILA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A914YZL0"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5062.t1">
        <property type="protein sequence ID" value="PSU_v2.g5062.t1"/>
        <property type="gene ID" value="PSU_v2.g5062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g5062.t1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13688" checksum="0E3B4D41A681D0CA" modified="2023-02-22" version="1">MSLGTKEDPGNIGLWDQIAALKFVKSNAFYFGGNPNNIIVWGQSAGSASVDLLTLSPHSRNLFDKAIEGSAAATSDFSEGKHSTQATKQLASAMGCKSSDAEEIKAFLKAQTWQDIMNVSSTKVKKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0F4</accession>
    <name>A0A914Z0F4_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0F4"/>
    <dbReference type="WBParaSite" id="PSU_v2.g565.t1">
        <property type="protein sequence ID" value="PSU_v2.g565.t1"/>
        <property type="gene ID" value="PSU_v2.g565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000887577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="WBParaSite" id="PSU_v2.g565.t1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16172" checksum="D7B3B15145F2F424" modified="2023-02-22" version="1">MSSLVAYVAINQTRTMVSEGEEVFITFASHLGFIFAATVIREGQAYRISKDHQSEVTALTQNWKKNFVGSTKPKKIILVKISETCWNELKEVFKEDKPEIYHLFDMRTLFNETMVDKVLHVMGVKTNEYEVHFLCQDVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914Z0K5</accession>
    <name>A0A914Z0K5_9BILA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Panagrolaimus superbus</name>
        <dbReference type="NCBI Taxonomy" id="310955"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Tylenchina</taxon>
            <taxon>Panagrolaimomorpha</taxon>
            <taxon>Panagrolaimoidea</taxon>
            <taxon>Panagrolaimidae</taxon>
            <taxon>Panagrolaimus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="WormBaseParasite"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A914Z0K5"/>
    <dbReference type="WBParaSite" id="PSU_v2.g5686.t1">
        <property type="protein sequence ID" value="PSU_v2.g5686.t1"/>
        <property type="gene ID" value="PSU_v2.g5686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000887577">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" des
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